key: cord-0905083-ove4mqis
authors: Annie, Frank H.; Dave, Sahil; Muhammad, Syed; Nanjundappa, Aravinda
title: Effect of SARS-COV-2 Diagnosis on Individuals with Preexisting Chronic Heart Failure
date: 2021-11-08
journal: Am J Cardiol
DOI: 10.1016/j.amjcard.2021.10.007
sha: 4cf46c3165e42c18ba06410f4608d57cfdc2faed
doc_id: 905083
cord_uid: ove4mqis

nan

The effect of SARS-COV-2 diagnosis on individuals with pre-existing chronic heart failure long-term outcomes is still poorly understood. The researchers aimed to determine whether there exists a difference in all-cause mortality between patients with a SARS-COV-2 diagnosis that received a pre-existing chronic heart failure diagnosis compared with those that did not have a diagnosis of chronic heart failure that contracted SARS-COV-2. Established research has connected poor outcomes to the previous history of heart failure. 1 The researchers queried the Trinetx (Covid-19 Research Network) which is composed of 63 health care organizations. They analyzed the data from January 20, 2020, to June 1, 2021, and identified n = 508,524 cases between the ages of 18 and 90 years with n = 21,274 with a previous history of heart failure which was defined using the International Statistical Classification of Diseases, Tenth Revision (ICD) 10 Code I50 and n = 487,240 patients with no previous diagnosis of heart failure. Descriptive statistics were used to measure the association between the 2 groups. A propensity score matching of a 1:1 was performed to match on the covariates (age, male, female, White, Black, Hispanic, hypertension, diabetes, coronary artery disease, chronic obstructive pulmonary disease, personal history of smoking, personal history of alcohol dependence, body mass index). The researchers were able to well match n = 20,428 of 20,428 over 550 days.

The researchers identified n = 508,514 patients aged 18 to 90 with differing ages between the 2 groups with chronic heart failure with average of (68.5 § 13.8 vs 47.7 § 17.9 p <0.001) compared to the group without chronic heart failure. The chronic heart failure group were more males (54.1% vs 44.5%, p <0.001) White (60.4% vs 54.9%, p <0.001), Black (21.7% vs 13%, p <0.001), hypertension (77.8% vs 24.2%, p <0.001) diabetes (50.7% vs 11.8%, p <0.001), coronary artery disease (44.4% vs 4%, p <0.001), personal history of smoking (24.0% vs 6%, p <0.001), personal history of alcohol dependence (3.4% vs 1.0%, p <0.001), body mass index (32. 1 § 8.37 vs 30.7 § 7.45, p <0.001) . Patients in the chronic heart failure group had a higher mortality of (15.3% vs 6.7%, p <0.001) A log-rank test also illustrated that those with a chronic heart failure diagnosis had a lower survival rate of (75.1% vs 89.6%, p <0.001) with a confirmed hazard of (2.73, p = 0.02).

The authors have no conflicts of interest to declare. 

Effect of heart failure on the outcome of COVID-19 -A meta analysis and systematic review