key: cord-0912776-82toumvg
authors: Fukushima, Takahiro; Kabata, Hiroki; Yamamoto, Ryo; Suhara, Tomohiro; Uwamino, Yoshifumi; Kondo, Yasushi; Masaki, Katsunori; Kamata, Hirofumi; Nagata, Hiromasa; Homma, Koichiro; Kaneko, Yuko; Ishii, Makoto; Sasaki, Junichi; Morisaki, Hiroshi; Hasegawa, Naoki; Fukunaga, Koichi
title: The real-time reverse transcription-polymerase chain reaction threshold cycle values for severe acute respiratory syndrome coronavirus 2 predict the prognosis of coronavirus disease 2019 pneumonia
date: 2021-01-28
journal: Respir Investig
DOI: 10.1016/j.resinv.2020.12.011
sha: cdb76b717c95e84509129efd610447435bf16861
doc_id: 912776
cord_uid: 82toumvg

The clinical course of coronavirus disease 2019 (COVID-19) varies from mild to critical. We retrospectively examined whether clinical and laboratory findings on admission could predict COVID-19 prognosis. Among various factors associated with COVID-19 severity, our results indicated that the real-time reverse transcription-polymerase chain reaction (RT-PCR) threshold cycle (Ct) values for severe acute respiratory syndrome coronavirus 2 were the most useful predictor of COVID-19 prognosis.

shows the summary of the clinical characteristics and laboratory findings of the 19 69 patients on admission. The median age was 69 years, and 16% of patients were female.

Hypertension and diabetes were present in 42% and 21% of patients, respectively. Most patients 71 had fever (63%) and dyspnea (68%). Lymphopenia, elevated neutrophil-to-lymphocyte ratio Next, we investigated which findings were different between the "critical illness" and "non- 

Labor and Welfare. Final report of monthly labor survey -March

Development 122 of henetic diagnostic methods for novel coronavirus 2019 (nCoV-2019) in Japan

Risk factors associated with acute 125 respiratory distress syndrome and death in patients with coronavirus disease 2019 126 pneumonia in Wuhan, China

Clinical characteristics of 128 coronavirus disease 2019 in China

Hematologic 130 parameters in patients with COVID-19 infection

D-dimer levels on admission to 132 predict in-hospital mortality in patients with COVID-19

Multiplex real-135 time PCR for detection of respiratory tract infections

MERS-CoV diagnosis: An uptodate

Clinical progression and 139 viral load in a community outbreak of coronavirus-associated SARS pneumonia: A 140 prospective study

SARS-CoV-2 viral load in sputum 142 correlates with risk of COVID-19 progression

All authors are required to disclose any COI within 3 calendar years preceding the current year, prior to the submission of any manuscript in the subject matter of which any company, entity, or organization has an interest.

No If Yes: List the name(s) of authors and commercial entity(ies) and use as much space as necessary