key: cord-0922096-4ei9gbu6
authors: Schmidt, Alexandra F.; Rubin, Alexandra; Milgraum, David; Wassef, Cindy
title: Vitiligo Following Coronavirus Disease (COVID-19): A Case Report and Review of Pathophysiology
date: 2022-02-10
journal: JAAD Case Rep
DOI: 10.1016/j.jdcr.2022.01.030
sha: 4299f39a87dd69268575b11bb8c6b4dabdc0a08f
doc_id: 922096
cord_uid: 4ei9gbu6

nan

Vitiligo is a depigmentation disorder that affects approximately 1% of the population of the 27 United States and Europe, with a peak age of onset earlier in females compared to males. 1 It 28 presents in females typically in the first decade of life, while males tend to present in the 29 fifth decade of life. 1 It is characterized by a patchy distribution of depigmented macules and is 30 subclassified by location and distribution of affected skin. 1 Vitiligo is hypothesized to be 31 autoimmune in nature, provoked by an environmental or biologic trigger that results in 32 destruction of melanocytes. 1 Vitiligo is associated with other autoimmune disorders and has been 33 reported to develop following the onset of viral illnesses such as human immunodeficiency virus 34 (HIV), hepatitis C virus and cytomegalovirus (CMV). 2 Severe acute respiratory syndrome 35 coronavirus 2 (SARS-CoV-2) infection has been linked to a rise in autoimmunity, with many 36 patients reporting novel post-viral autoimmune conditions. 3 In this report, we present a patient 37 with no history of autoimmune disease who developed vitiligo after contracting SARS-CoV-2 38 infection. 39 

Viral causes of vitiligo: a new perspective for 116 vitiligo pathogenesis

Autoimmune and inflammatory disease following COVID-19

Vitiligo Pathogenesis and Emerging Treatments

Vitiligo: A review

The triggering of post-COVID-19 autoimmunity phenomena could be 125 associated with both transient immunosuppression and an inappropriate form of 126 immune reconstitution in susceptible individuals

COVID-19 and Oxidative Stress

New-onset vitiligo following mRNA-1273 (Moderna)

COVID-19 vaccination

J o u r n a l P r e -p r o o f described in the pathogenesis of vitiligo, this suggests another potential linkage between 95 vitiligo and COVID-19. 96Oftentimes the "stressor" that triggers vitiligo remains unknown; it is therefore possible 97 that this case presents as a timely coincidence. However, our patient's age of 52 is above the 98 average age of 20 to 30 years old for the initial presentation of vitiligo. 5