key: cord-0931031-yytkrlx7
authors: Daisley, Hubert; Rampersad, Arlene; Daisley, Martina; Ramdin, Amit; Acco, Oneka; Narinesingh, Farhaana; Humphrey, Ornella; James, Errol
title: The vasa vasorum of the large pulmonary vessels are involved in COVID-19
date: 2021-08-20
journal: Autopsy & case reports
DOI: 10.4322/acr.2021.304
sha: 76e203cb36b3a24ebcb42d62cbe03738d6864c26
doc_id: 931031
cord_uid: yytkrlx7

nan

In our manuscript "COVID-19: a closer look at the pathology in two autopsied cases. Is the pericyte at the center of the pathological process in COVID-19?" ; 1 The significance of these sites means that both, the alveolar microcirculation and the vasa vasorum of the large pulmonary vessels are involved in the thrombotic processes in COVID-19. The latter thrombotic site would further implicate COVID-19 as a disease of the microcirculation. Boyle and Haverich 3 postulated that "the involvement of the large vessels during coronavirus disease 19 (COVID-19) in both children and adults is likely due to dysfunction of their vasa vasorum and SARS-COV-2 induced microthrombosis of vasa vasorum would lead to hypoxic conditions in the adventitia."

As the world is grappling with the SARS-COV-2 pandemic, it is essential to understand the pathogenesis of COVID-19 to formulate therapeutic options. It may be that the lung is a secondary partner in COVID-19 and the pathogenesis of this disease begins in the nasopharynx, 4 where there is an abundance of ACE-2 receptor sites. SARS-COV-2 interaction at the port of entry in the nasopharynx produces chemokines/ cytokines, 3, 5 which circulates in the systemic circulation, causing endotheliopathy and subsequent thrombotic microangiopathy 6 being the ultimate result.

COVID-19: a closer look at the pathology in two autopsied cases. Is the pericyte at the center of the pathological process in COVID-19? Autops Case Rep

Functional anatomy and hemodynamic characteristics of vasa vasorum in the The vasa vasorum of the large pulmonary vessels are

2021;11:e2021304 walls of porcine coronary arteries

Microvasculature dysfunction as the common thread between atherosclerosis, Kawasaki disease, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) associated multi-system inflammatory syndrome in children

The central role of the nasal microenvironment in the transmission, modulation, and clinical progression of SARS-CoV-2 infection

COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms

COVID-19 and thrombotic microangiopathies