key: cord-0932390-e6jix8s5
authors: Burgos‐Blasco, Patricia; Fernandez‐Nieto, Diego; Selda‐Enriquez, Gerald; Melian‐Olivera, Ana; De Perosanz‐Lobo, Darío; Dominguez‐Santas, Miguel; Alonso‐Castro, Leticia
title: COVID‐19: a possible trigger for oral lichen planus?
date: 2021-03-08
journal: Int J Dermatol
DOI: 10.1111/ijd.15529
sha: 3a03f51af89d6a09da4ac562669b47d1d63480d4
doc_id: 932390
cord_uid: e6jix8s5

nan

Since the outbreak of coronavirus disease in December 2019, a wide variety of associated dermatological manifestations have been reported. Most of the described cutaneous lesions are physiopathologically explained by a tendency to thrombosis and immunological changes. The latter could represent a trigger in the development of other immune-mediated skin diseases not yet associated with COVID-19. We present a case of oral lichen planus after COVID-19 infection.

A 56-year-old female was admitted to our hospital with a 5-day history of fever, cough, and dyspnea. A nasopharyngeal swab was performed, testing positive for SARS-CoV-2. X-ray images were unremarkable, and the patient was discharged with symptomatic treatment. Two weeks later, she consulted for the appearance of violaceous plaques over the dorsal aspects of her digits, consistent with a diagnosis of COVID-19 pseudochilblain (Fig. 1a) . A month later, coincident with the resolution of acral lesions, she started to develop a widespread papulosquamous eruption on the trunk, compatible with pityriasis rosea (Fig. 1b) . Physical examination also revealed a bilateral lace-like pattern on buccal mucosa with no other skin lesions, reaching the diagnosis of oral lichen planus (Fig. 1c) . The patient had no relevant medical history and had not introduced new medication during the previous month, other than paracetamol prescribed for COVID-19 symptoms. Serologic analyses were negative for hepatitis C virus (HCV) and detected the presence of SARS-Cov-2 IgG antibodies, revealing seroconversion for COVID-19. Skin biopsy was not performed because of the patient's preferences.

Oral lichen planus is a chronic inflammatory disorder, whose pathogenesis is not entirely understood. Growing evi- 

The patient in this manuscript has given written informed consent to publication of her case details. 

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Dysregulation of immune response in patients with COVID-19 in Wuhan, China

The cytokine storm in COVID-19: An overview of the involvement of the chemokine/ chemokine-receptor system

Pityriasis rosea as a cutaneous manifestation of COVID-19 infection

ª 2021 the International Society of Dermatology

Funding source: None. doi: 10.1111/ijd.15529