key: cord-0948979-729h8528
authors: Rangashamaiah, Sriranga; Hayagreev, Vibha; Krishnan, Shanmugam; Prabhavathi, Bhat; Manjunath, Cholenahalli Nanjappa
title: The impact of COVID19 Nationwide Lock-down on STEMI hospitalization and outcomes in South India
date: 2021-03-24
journal: Indian Heart J
DOI: 10.1016/j.ihj.2021.03.008
sha: b72d49b5be4c6e2a8b84d1428693b60b4a1774f2
doc_id: 948979
cord_uid: 729h8528

Covid-19 Nationwide lockdown for social containment was implemented on the 23rd of March 2020. The objective of this study was to look at the impact of lockdown on STEMI (<24hrs window period). This study was done in 2 phases, 43 days before (phase1) and 43 days during lockdown (phase 2). During the lockdown, there was a 31% decrease in hospital admission rates, 11.5% and 9.38% proportional increase in diabetics and hypertensive patients presenting with STEMI. The public must be educated about the existing important health problems in the community along with the pandemic warnings.

The first cluster of novel corona virus-(SARS-related CoV-2) was identified in Wuhan, a city in central China towards the end of 2019 (1) . The first confirmed case of COVID-19 in India was reported from Kerala, a south Indian state on 30th January 2020 (2) . Since then there has been a rapid escalation of COVID-19 cases in the country due to its high secondary attack rate (3) . Understanding the epidemic and witnessing the developed countries being crumbled by the pandemic, the Indian government imposed the nationwide lockdown (social containment) from the 23rd of March to buy time for preparedness of health infrastructure and containing the spread in the community.

The objective of the study is to assess the collateral impact of Lockdown on admission rates and in-hospital mortality rates of acute coronary syndrome -ST-elevation Myocardial Infarction (STEMI).

The study was done after Institutional ethics committee approval (Ref No -SJICSR/EC/2020/017). Patients consecutively admitted to the hospital with ACS-STEMI (Window Period < 24 hrs) were included. The patients were treated with pharmaco invasive therapy which is comparable to primary PCI in outcomes. Patients were initially thrombolysed (with streptokinase predominantly than fibrin specific agents) and the successfully thrombolysed patients were taken for an angiogram on the following day, or the rescue PCI was done as and when needed (4) . For Phase 1 of the study, the retrospective data were collected from the Medical record section. During the second phase data was prospectively collected (Figure 1 ).

The analysis was done in SPSS (Statistical Package for the Social Sciences) version 26 software. The Metric variables between 2 phases were analyzed by using an independent Ttest or Mann-Whitney test wherever applicable. The odds ratio of risk factors for death was analyzed by Binominal multivariate analysis.

It was observed that compared to Prelockdown phase hospital admission rates during lock down phase dropped by 31.04% (Table 1) . Anterior wall STEMI was most common in both the phases {335(56.7) vs. 185(59.5%) (p= 0.418)}.

Among the risk factors, T2DM and HTN were more prevalent during the lockdown phase. Other risk factors like prior IHD, smoking, and tobacco chewing didn't show any difference. The case fatality rate didn't differ between the two groups.

Higher blood sugars, development of renal dysfunction, and heart blocks predicted higher mortality in both the phases whereas better Ejection fraction before thrombolysis was protective (Table 2) .

The study centre witnessed a significant drop in admission rates from 14 to 8 per day due to lock down, as witnessed in other countries (5) . The centre is one of the largest cardiac set up in South Asia which caters cardiac admission to three southern states of India. Our country is still dependent on public transport for health care access. The cardiac specialty is available at only tertiary care hospitals at districts or state headquarters, the ban on inter-district and interstate travel due to lockdown may have decreased access to the transport facilities causing reduced hospital admissions. The fear of hospital-acquired corona infections could be the other possible explanation (6). Also, the MI with atypical presentations that otherwise would have been picked up might not have been diagnosed. Apart from the admission rates, there was no significant difference in case fatality rates during these two periods 91(15.4%) vs. 62(19.9%), p = 0.084. Our death rate is significantly higher than in Kerala ACS and CREATE registry possibly due to tertiary centre bias, exclusion of evolved STEMI, late presentation, fibrinolysis being the preferred treatment due to multiple socioeconomic factors, and Covid-19 related logistics of non-interventional management (7).

In-hospital mortality may not represent true long-term outcomes that were not studied in our study. Details on guideline directed medical therapy, duration of hospital stay and risk factors for mortality such as arrhythmias haven't been included in the study. Our study may not reflect the true population incidence of MI due to transport issues and referral bias. The true decrease in MI can be deciphered only from birth and death registries.

Nationwide lockdown provided time for the preparedness of the medical system for the impact of COVID 19 by curbing the rate of rising in the number of cases. However, it did have its collateral impacts on all other areas including the difficulty in access of patients to health care due to transportation issues. This study emphasizes that people without risk factors may have been hesitant to visit health care. Along with the COVID warnings for the general public, there must be health education to contact health care facilities with the onset of symptoms and the existing diseases cannot be ignored because of the pandemic. 

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia

Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study

Pharmacoinvasive Strategy Versus Primary Percutaneous Coronary Intervention in Patients With ST-Segment-Elevation Myocardial Infarction: A Propensity Score-Matched Analysis

Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era

Valvular heart diseases

Infective endocarditis

Admissions due to Tachy and bradyarrhythmias ( except secondary to STEMI )

STEMI cases screened 278 cases excluded = wp >24 hrs (125 cases during prelock down , 153 cases during lock down)

ACS -Acute coronary syndrome

UA/NSTEMI -Unstable angina/ NST elevation Myocardial Infarction ; STEMI -ST elevation Myocardial Infarction