key: cord-0974720-yiolh26k authors: Adam, Ishag title: Is herpes zoster being an indicator for COVID 19 infection? date: 2020-06-16 journal: Dermatol Ther DOI: 10.1111/dth.13846 sha: de442080ec3ee14262999933f11896b07c5319bd doc_id: 974720 cord_uid: yiolh26k nan It is recognized that the majority of the infections with COVID-19 presented with mild and moderate symptoms, however, the minority (15%) of the infections can progress to severe pneumonia and acute respiratory distress syndrome (ARDS), or can progress to multiple organ failure [1] . Morbilliform rashes, chicken-pox like lesions, covid toe and a various lesions were the main skin manifestations reported during COVID 19 epidemics [2] . There are recent reports on cases of herpes zoster infections among a symptomatic COVID-19 infection [3, 4] . Therefore, identifying or to raise the suspicion of the asymptomatic carriers is of paramount in the management of COVID-19 outbreak. infections is the lymphopenia (which can favour herpes virus recurrences) which is a result of infecting lymphocytes and activation-induced cell death and impairment to antiviral responses [5] . Therefore, the point of herpes zoster infections among a symptomatic COVID-19 infection should be put in mind when a broad immunosuppression is used in patients with severe viral illness and the pros and cons of anti-inflammatory effects versus the delay of virus clearance [6] . The author declares no conflict of interest. This article is protected by copyright. All rights reserved. Clinical features of patients infected with 2019 novel coronavirus in Wuhan Cutaneous Signs in COVID-19 Patients: A Review COVID-19 and herpes zoster co-infection presenting wi th trigeminal neuropathy Herpes Zoster Might Be an Indicator for Latent COVID 19 Infection -PubMed Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients Immunosuppression for hyperinflammation in COVID-19: a double-edged sword?