key: cord-0976783-6rtu9d0q
authors: Mateu-Salat, M.; Asla, Q.; Chico, A.; Martínez, M. C.; Martínez, M. J.; López, A.; Pujol, I.; Corcoy, R.
title: Feasibility of maintaining near-normal glucose control in pregnant women with type 1 diabetes during COVID-19 lockdown
date: 2022-03-01
journal: Acta Diabetol
DOI: 10.1007/s00592-022-01862-7
sha: 8bf1cefdce339e41b652734ba078a16c95b3a7b0
doc_id: 976783
cord_uid: 6rtu9d0q

nan

(TBR) as < 25%, > 70%, and < 4% respectively after Battelino et al [2] . We did not prespecify imputations for missing data. Descriptive statistical analysis was performed with StataMP v14. Variables are expressed as percentages or median values (interquartile range).

Twenty women with type 1 diabetes were pregnant during lockdown and 14 of them fulfilled inclusion criteria (4 of them became pregnant after lockdown initiation, and 2 did not use rtCGM/isCGM or initiated it later).

Average age at the beginning of pregnancy was 36 years (33-39) and diabetes duration 20 years (17-22). Four (29%) women were previous smokers, five (36%) had retinopathy and one had diabetic nephropathy (microalbuminuria). The average prepregnancy body mass index was 23.8 kg/m [2] (21-28). Eight (57%) patients used multiple injection therapy and isCGM, and six (43%) used sensor-augmented pump therapy (Medtronic 640G®); all women used insulin analogs.

Most patients had specific pregestational follow-up (n = 12; 86%). All pregnancies were singleton, and 3 women (21%) had undergone an in vitro fertilization process. Average gestational age at the start of lockdown was 13.1 weeks (10-23.1). One woman had a miscarriage. During lockdown, patients had 1.5 (1-2) in-person endocrinological appointments in addition to 5 (3-6) remote asynchronous consultations.

Glucose data per week is displayed in Fig. 1 . All participants had information for all included pregnancy weeks. In week 0, average time of sensor use was 99.5% (95-100), mean blood glucose was 108.5 mg/dL (99-130) [6.02 mmol/L, (5.5-7.2)]) and TBR, TIR and TAR were respectively 5% (4-6%), 71.5% (59-79%), and 18.5% for mean blood glucose, 4% (3-10%) for TBR, 74.25% (68-80.5%) for TIR, and 19.5% (8-28%) for TAR. Weekto-week glucometrics did not display major modifications and were similar to or nominally better than those of week 0. According to average values, 5 (36%) women were in target for TBR during the lockdown period, 9 (64%) for TIR and 10 (71%) for TAR. The global picture was similar for women that at week 0 were above or below the median gestational age of 13.1 weeks (data not shown). There were no episodes of severe hypoglycemia (SH) or diabetic ketoacidosis.

Glycemic control in pregnant women with diabetes is a priority in times where resources are limited, such as during a pandemic. In this line, the ABCD position statement on risk stratification of adult patients with diabetes during COVID-19 pandemic [3] includes as urgent priority those women who are planning pregnancy in the next 6 months. In this report, overall figures of glucose control were satisfactory except for TBR. The low rate of women achieving the TBR target is not necessarily bad news taking into account that no SH episode was reported and that according to a recent report of the CONCEPTT trial [4] achieving the TBR target is associated with a higher risk of pre-eclampsia and neonatal hypoglycemia suggesting that the range may include some readings that would actually be "normal". The satisfactory glucose control is remarkable considering the tight targets and varying insulin requirements during pregnancy. We attribute it to the combination of women's commitment, skilled education, availability of technology, and feasibility of remote consultations. The main limitations of this report are the number of included women and considerations for external validity; its main strengths are the longitudinal analysis, the lack of missing data, and high time of sensor use.

In conclusion, in pregnant women with type 1 diabetes mellitus, glucose metrics after rtCGM/isCGM during lockdown were satisfactory and, in relation to week 0, were similar or even nominally better. Near-normoglycemia in pregnant women with type 1 diabetes is feasible [5] , also in pandemic times.

The impact of strict COVID-19 lockdown in Spain on glycemic profiles in patients with type 1 Diabetes prone to hypoglycemia using standalone continuous glucose monitoring

Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range

ABCD position statement on risk stratification of adult patients with diabetes during COVID-19 pandemic

Continuous Glucose Monitoring Time-in-Range and HbA 1c Targets in Pregnant Women with Type 1 Diabetes

Feasibility of maintaining normal glucose profiles in insulin-dependent pregnant diabetic women

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