key: cord-0977027-z5fd39zl authors: Kateeb, Elham; Danadneh, Mayar; Pokorná, Andrea; Klugarová, Jitka; Abdulqader, Huthaifa; Klugar, Miloslav; Riad, Abanoub title: Predictors of Willingness to Receive COVID-19 Vaccine: Cross-Sectional Study of Palestinian Dental Students date: 2021-08-26 journal: Vaccines (Basel) DOI: 10.3390/vaccines9090954 sha: 0b11a2a80010a957ada8c70241a8ff7c66abfa9f doc_id: 977027 cord_uid: z5fd39zl The overarching aim of this study was to assess the predictors related to the willingness of Palestinian dental students to receive the COVID-19 vaccine when it becomes available. A cross-sectional study was conducted among a universal sample of dental students in the Palestinian territories. Willingness to get the COVID-19 vaccine was related to the following factors: Demographic characteristics, COVID-19-related experiences, beliefs and knowledge about the vaccine, attitudes toward vaccinations in general, and other factors outlined by the WHO SAGE Vaccination Hesitancy Questionnaire. Four hundred and seventeen students completed the questionnaire (response rate = 41.7%). In general, 57.8% (n = 241) were willing to take the COVID-19 vaccine when it became available to them, 27% (n = 114) were hesitant, and 14.9% (n = 62) were not willing to get vaccinated. The final regression model explained 46% of the variation in the willingness to receive the COVID-19 vaccine as follows: Attitudes towards new vaccines (β = 6.23, p < 0.001), believing in a favorable risk–benefit ratio (β = 5.64, p < 0.001), trust in the pharmaceutical industry (β = 5.92, p = 0.001), believing that natural immunity is better than being vaccinated (β = −4.24, p < 0.001), and having enough information about the vaccine (β = 4.12, p < 0.001). Adequate information about vaccines, their risk–benefit ratios, and natural and acquired immunity are important to build trust and favorable attitudes towards vaccines among future dentists. The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) emerged in December 2019 and was declared as a pandemic in March 2020 [1] . As of 2 July 2021, 182 million cumulative cases and almost four million deaths have been recorded worldwide [2] . Global collaborative efforts had led to the rapid development of vaccines against COVID- 19. In December 2020, several vaccines were authorized worldwide and approved by the World Health Organization (WHO) to prevent COVID-19 infection [3] . Vaccination campaigns have begun in various countries at different speeds using different implementation strategies depending on availability, rollout speed, and acceptance rates among people [4] . In addition to the increased occupational risks of the dental practice, COVID-19 brought a new challenge for oral health professionals through its oral symptoms that still have no clear pathophysiology or prevalence. COVID-19-associated oral manifestations were increasingly reported in the last months, e.g., loss of taste (dysgeusia), perioral and intraoral ulcers, oral candidiasis, oral mucositis, and parotid gland inflammation; therefore, they are widely viewed as a demanding knowledge gap that requires rigorous investigation by dental researchers and practitioners [30] [31] [32] [33] [34] [35] [36] . Reports regarding the willingness of dentists and dental students to become vaccinated varied across different countries, according to the economic status of the country surveyed, and among individuals, based on the inadequacy of knowledge about vaccines, and the mistrust of governments and the pharmaceutical industry [37, 38] . Most studies that assessed vaccine hesitancy used the proxy "willingness to get the vaccine when it becomes available". Although willingness may not always correlate with actual behavior, including for vaccination, it is still a good indicator of acceptance and can give public health campaigns advance notice of whom to target in their vaccination promotion programs [39, 40] . Therefore, this study aimed to assess the predictors related to willingness to receive the COVID-19 vaccine when it becomes available among a universal sample of dental students in different educational institutions in the West Bank and Gaza areas of the Palestinian territories. This study specifically assessed factors related to students' knowledge, beliefs, and attitude and their association with the decision to get vaccinated. At the time of data collection in February 2021, a formal vaccination campaign had not started yet in Palestine. We hypothesized that factors such as trust, beliefs, and level of knowledge are influential in dental students' decisions to become vaccinated. Data for the current study were extracted from a global cross-sectional multicounty survey conducted in the months of February and March of 2021 by the International Association of Dental Students (IADS) [41] . The global study was coordinated by the IADS national scientific committees in 22 countries and aimed to evaluate the dental students' hesitancy levels towards COVID- 19 vaccines. An online self-administered questionnaire (SAQ) that included closed-ended multiple-choice items was developed through KoboToolbox (Harvard Humanitarian Initiative. Cambridge, MA, USA, 2021) [42] . The questionnaire was sent out to undergraduate dental students and interns in the four Colleges of Dentistry in the Palestinian territories: Al-Quds University, the Arab American University in the West Bank area, Al-Azhar University, and the University of Palestine in Gaza Strip. The students who were enrolled in the 4 dental colleges in the academic year 2020/2021 and attended any year of the five academic levels of the dental surgery degree in Palestine or attended the internship year were eligible to participate in this study. The "clinical internship" is an obligatory year that students need to complete immediately after finishing their formal training before getting their full licensure to practice ( Figure 1 ). The official students' Facebook (FB) groups for each college were used as our sampling frames, and two reminder messages, one week apart, were sent through the messenger application. The total number of students and interns in the Palestinian territories is 3650; 96% of them (n = 3500) could be found in these FB groups. A minimum sample of 379 was calculated using the Epi Info™ Version 7.2.4.0 online calculator to achieve a 95% confidence level and a 5% margin of error [43] . The official students' Facebook (FB) groups for each college were used as our sampling frames, and two reminder messages, one week apart, were sent through the messenger application. The total number of students and interns in the Palestinian territories is 3650; 96% of them (n = 3500) could be found in these FB groups. A minimum sample of 379 was calculated using the Epi Info™ Version 7.2.4.0 online calculator to achieve a 95% confidence level and a 5% margin of error [43] . The SAQ included 20 multiple-choice questions that covered four sections: (1) Demographic data including gender, age, academic level, or professional status (as an intern or a fresh graduate); (2) COVID-19-related experience including the previous infection, providing care to a COVID-19 patient, having a COVID-19 patient within the students' close social circle, and having a deceased COVID-19 patient within the students' close social circle; (3) willingness to get the COVID-19 vaccine; and (4) factors influencing the decision to get the COVID-19 vaccine and students' attitudes towards new vaccines in general. An expert panel consisting of two professors and two senior researchers selected the questions for Section 4 from a validated instrument published by the WHO-SAGE (Vaccine Hesitancy Survey Questions Related to SAGE Vaccine Hesitancy Matrix) [44] . Additional pilot testing was carried out to test face validity and item reliability for the whole instrument by 18 dental students who were invited to fill in the questionnaire twice with a minimum interval of 48 h. The mean Cohen's kappa coefficient of the test-retest was 81.83 ± 0.16 (0.55-1.0), indicating very good reliability [38] . The SAQ included 20 multiple-choice questions that covered four sections: (1) Demographic data including gender, age, academic level, or professional status (as an intern or a fresh graduate); (2) COVID-19-related experience including the previous infection, providing care to a COVID-19 patient, having a COVID-19 patient within the students' close social circle, and having a deceased COVID-19 patient within the students' close social circle; (3) willingness to get the COVID-19 vaccine; and (4) factors influencing the decision to get the COVID-19 vaccine and students' attitudes towards new vaccines in general. An expert panel consisting of two professors and two senior researchers selected the questions for section 4 from a validated instrument published by the WHO-SAGE (Vaccine Hesitancy Survey Questions Related to SAGE Vaccine Hesitancy Matrix) [44] . Additional pilot testing was carried out to test face validity and item reliability for the whole instrument by 18 dental students who were invited to fill in the questionnaire twice with a minimum interval of 48 h. The mean Cohen's kappa coefficient of the test-retest was 81.83 ± 0.16 (0.55-1.0), indicating very good reliability [38] . All subjects completed digital informed consent that emphasized the voluntary nature of their participation and the measures that were taken to ensure their confidentiality and privacy prior to filling out the questionnaire. The study protocol had been reviewed and approved by the Ethics Committee of the Faculty of Medicine, Masaryk University (MUNI) on 20 January 2021, with reference No. 4/2021. Administrative approval was obtained from the Deanship of Scientific Research at Al-Quds University to collect data in Palestine. The questionnaire was anonymous, and the study data were collected and managed by MUNI in full compliance with the European General Data Protection Regulation 2016/679 (GDPR) [45] . Statistical analysis was conducted using the Statistical Package for the Social Sciences (SPSS) version 27.0 (SPSS Inc., Chicago, IL, USA, 2020) [46] . Descriptive statistics, frequencies, percentages, cumulative percentages, means, and standard deviations were generated for all study variables, both independent and dependent variables [38] . Independent variables included all variables in sections 1, 2, and 4. For analysis purposes, students in the "Academic Level" variable were categorized into two levels: Preclinical (first year, second year, third year) and clinical (fourth year, fifth year, interns, and fresh graduates). This reflects when clinical courses are introduced for these students, which usually happens in the 4th year with minimal clinical training before that. Descriptive statistics also described our main dependent variable, "Willingness to get the vaccine when it becomes available", which was measured on a 5-point Likert scale (1 = Strongly Disagree, 2 = Disagree, 3 = Not Sure, 4 = Agree, 5 = Strongly Agree). For descriptive statistics purposes, the dependent variable in this study was further categorized into three levels: "willing to get the vaccine", which included the two ratings: Strongly Agree and Agree, "Hesitant to get the vaccine", which included "Not sure", and "Unwilling to get the vaccine", which included "Strongly Disagree and Disagree". Bivariate analysis was conducted using Spearman's correlation, the Mann-Whitney (U) test, the Kruskal-Wallis (H) test, and the Chi-squared test to assess the association between our dependent variable (the 5-point rating format) and other independent variables. The significance level was set to (p) ≤ 0.05 [38] . Finally, β statistics from the multiple linear regression model of the dependent variable, "Willingness to get the COVID-19 vaccine", were calculated. The dependent variable used here was a five-point scale treated as a continuous variable in the regression model. Predictor variables that were found statistically significant in the bi-variable analysis were entered into the regression model using a stepwise technique and confirmed by back-ward and forward regression analysis. Four hundred and seventeen students from the four colleges of Dentistry in the Palestinian territories, including the West Bank and Gaza, completed the questionnaire (response rate = 41.7%). Seventy-one percent (n = 295) of the sample was female students, which reflects the real proportion of female students in Palestinian dental schools (70% of total graduates are females). Almost 48% (n = 202) of the sample were in preclinical years and 52% (n = 215) in clinical years, including the internship year. While 22 years old was the median age of the global sample, 86.1% of the Palestinian students were aged 22 years or below (Table 1) . Nineteen percent of our sample (n = 81) were aware that they had been infected by the SARS-CoV-2, 90% (n = 375) knew someone who had been infected in their close circle, and 51% (n = 211) knew a person who died from COVID-19 (Table 2) . In our sample, 53% (n = 220) had never taken an influenza vaccine before, 23% (n = 94) indicated that they always take the influenza vaccine when it is available to them, and only 2.6% (n = 11) indicated that the influenza vaccine is mandatory in their settings (Table 3) . In general, 14.9% (n = 62) were not willing to take the COVID-19 vaccine when it became available to them, 27% (n = 114) were hesitant, and 57.8% (n = 241) were willing to be vaccinated. Reports in social media influenced the decision to receive the COVID-19 vaccine in 47% (n = 195) of our sample, and 31% (n = 128) were influenced by celebrities and religious and political leaders when making such a decision (Table 4 ). Almost 30% (n = 123) of our sample did not trust the government to make the best decision about purchasing the highest quality of vaccine, and 21% (n = 88) did not trust pharmaceutical companies to provide credible data on vaccine safety and effectiveness. In addition, 28% (n = 117) were not sure that their health centers would have the vaccine available to them when they need it. When participants were asked about better ways to become immune against the COVID-19, 52% of our sample (n = 215) believed that getting sick and acquiring natural immunity is a safer choice than getting the vaccine. This belief was even more emphasized when 33.6% (n = 140) were not sure if the benefits of COVID-19 vaccines outweigh their reported side effects and 18.5% (n = 77) did not believe they do. In general, 35.5% (n = 148) did not think they have enough information about the COVID-19 vaccines and their safety, and 26.4% (n = 110) were not inclined to consent when a new vaccine is introduced, in general. Sixty-six percent of our sample did not hear about anyone who does not want to take the vaccine because of cultural or religious values (Table 5 ). In the bivariate analysis, willingness to become vaccinated in this sample was statistically associated with the influence of social media (H = 11.97, p = 0.003) and the opinions of celebrities, religious, and political leaders (H = 48.89, p < 0.001). Willingness to receive the vaccination was also statistically associated with trust in governments making the right decisions about the vaccine (H = 82.32, p < 0.001), trust in the pharmaceutical industry to provide credible data about vaccines (H = 106.6, p < 0.001), and confidence in the health care system to make these vaccines available when needed (H = 83.6, p < 0.001). The belief that natural immunity can be a better option to prevent infection (H = 8.5, p < 0.001) and that the benefits of the vaccine outweigh its risks (H = 134.82, p < 0.001) were also associated with willingness to receive the vaccine. The attitude towards new vaccines in general (H = 143.83, p < 0.001) was a predictor of willingness to get the COVID-19 vaccine. The attitude of the participants in this sample towards introducing new vaccines, in general, was influenced positively by being infected before (χ 2 = 8.5, p = 0.014) and negatively by knowing someone who died from COVID-19 (χ 2 = 5.5, p = 0.05). Additionally, willingness to receive the vaccine was influenced by participants' position on vaccine hesitancy based on religious or cultural beliefs (H = 10.78, p = 0.005). Finally, the knowledge about vaccine safety (H = 94.5, p < 0.001) was also a predictor for willingness to receive the vaccine in a bivariate relationship (Table 6 ). Female students were less willing to become vaccinated, U-test = 13,289, p < 0.001; on the other hand, the academic year of the participants did not affect their decision. Never getting a flu vaccine (U = 13,684, p < 0.001) and always getting a flu vaccine (U = 8981, p < 0.001) significantly influenced willingness to receive the COVID-19 vaccine (Table 7 ). In the final model, willingness to become vaccinated was explained by the following factors: Attitudes towards new vaccines (β = 6.23, p < 0.001), believing in a favorable riskbenefit ratio (β = 5.64, p < 0.001), trust in the pharmaceutical industry (β = 5.92, p = 0.001), believing that natural immunity is better than being vaccinated (β = −4.24, p < 0.001), and having enough information about the vaccine (β = 4.12, p < 0.001). This model explained 46% of the variation in willingness to receive the COVID-19 vaccine (Table 8 ). About 58% of dental students in Palestinian educational institutions were willing to get vaccinated against COVID-19 when it becomes available to them. However, willingness to get vaccinated was influenced by attitudes towards new vaccines in general, students' beliefs about vaccines' risk-benefit ratio and natural immunity, trust in the pharmaceutical industry, and having enough information about the vaccine. In the current COVID-19 pandemic, it was expected that HP would be more willing to become vaccinated and encourage the public to do so. Research shows that patients are more likely to accept vaccination when they receive a strong recommendation from their HP [47] . Recent literature reviews on COVID-19 vaccine hesitancy worldwide found that HP hesitancy rates ranged from 27.7% to 78% compared to hesitancy rates in the general public (23.6% to 97%) [48] . Most of the studies that assessed vaccine hesitancy were conducted when vaccines were not yet available, and their mechanisms of action were still unknown [14, 49] . At the time of this study, COVID-19 vaccines were already available, and in several countries, the COVID-19 vaccination rollout had already started. In Palestine, the public had been promised the start of vaccination administration at the end of February 2021, but the actual campaign started at the beginning of March 2021 [5] . This study aimed to assess the willingness of dental students to get the COVID-19 vaccine when it becomes available to them. So far, there are no reports from Palestine that investigate the vaccine hesitancy rate in any strata of Palestinian society. In many countries, dentists were prioritized for vaccination as members of HP teams and because of the well-documented evidence of virus transmission through aerosols and droplets, which places dentists at an even higher risk for potential exposure to the SARS-CoV-2 virus [50] . At the time of writing this current analysis, most dentists were already vaccinated, but dental students are still in the queue. Because of the low availability of the vaccine, the Palestinian Authority's national strategy for vaccines rollout prioritizes HP at older ages and other community strata such as teachers over young HP students. This current analysis reported 14.9% rejection and 27% hesitancy towards the COVID-19 vaccine among dental students in this sample. In the United States, dental students showed higher levels of hesitancy (45%) [51] . This can be explained by the timeframe of data collection. The US data were collected in November 2020, when no vaccine was authorized yet by the Food and Drug Administration (FDA) or the WHO while our data were collected at the end of February 2021, when vaccination campaigns including more evidence on their effectiveness and safety were released worldwide. On comparing Palestine's data with the global average for dental students' hesitancy rates collected at the same time using the same methodology, we found numbers in the current analysis to be a bit higher (14.9% vs. 13.9% rejection and 27% vs. 22.5% hesitancy) [38] . Although reports on global and regional trends of hesitancy are very important, specific country data are very valuable to tailor targeted vaccination awareness programs to specific communities. Vaccine hesitancy as documented in the literature is a multifactorial phenomenon that has many cultural and societal influencers. Therefore, to understand the predictors of this behavior, willingness to become vaccinated as a proxy of vaccine hesitancy was further explored in our sample with bivariate and multivariate analysis. Similar to results of the global survey of dental students, Palestinian students had issues in trusting their government to make the right decisions about the vaccine and the pharmaceutical industry to provide credible data about vaccines, and this mistrust significantly lowered their levels of willingness to receive the vaccination [38] . Female students in this sample were less willing to become vaccinated, and this agrees with the global data on dental students' hesitancy but disagrees with US dental students' data as well as dentists' hesitancy levels in Italy where there was no difference between the two genders in acceptance rate [37, 38, 51] . A recent meta-analysis on vaccine hesitancy among health workers (HCWs) showed that male participants were more likely to receive the COVID-19 vaccine compared to females when it was available. The previous study suggested that this phenomenon could be because of the reported higher mortality rates among males due to COVID-19 [52] . Interestingly, the year of the study did not affect the willingness rate in this current study. This suggests that advancing through dental training does not better qualify students in sciences related to infectious diseases and vaccines. Almost 36% of the current sample thought that they did not have adequate knowledge about the safety and effectiveness of the COVID-19 vaccines. This lack of information was also a strong predictor of vaccine hesitancy. This is in line with vaccine hesitancy predictors found in other studies for similar populations [37, 38] . Unfavorable attitude towards any new vaccine in the current sample was also a predictor of COVID-19 vaccine hesitancy. Being infected by COVID-19 made participants more positive about getting vaccinated in general; however, knowing someone who died because of COVID-19 made participants more negative in their attitude towards vaccination in general. This suggestive border result might reflect how the experience of a relative or a friend death provoked the negative beliefs about disease and vaccination. The beliefs that natural immunity is a better way to prevent infection and that the benefits of the vaccine do not outweigh its risks were all drivers to the unwillingness to become vaccinated. This also agrees with factors that influenced dentists' decisions to become vaccinated in another study [37] . Less than half (48%) of the participating students in our sample believed that the COVID-19 vaccine benefits could outweigh their side effects. This suboptimal percentage can be explained by the fact that there was a lack of publicly available safety evidence for the early vaccines used in Palestine, namely Sputnik V and Sinopharm. It is worth mentioning that the passive surveillance systems utilized widely by the drug regulators and governments were found to be inefficient in evaluating the prevalence of COVID-19 side effects, including the common ones like fatigue, headache, and muscle pain; therefore, this study's findings support the global demand for independent post-marketing studies to evaluate vaccines safety and effectiveness [53] [54] [55] [56] . The influence of social media, opinions of celebrities, and religious and political leaders were also determinants in dental students' decisions. This was also true in the global survey of dental students' hesitancy rates [38] . Using public figures and influencers through social media seems to be effective in delivering health promotional messages, as documented in the literature [57] . However, in the current pandemic and with other types of immunizations, social media was used aggressively by the antivaccine campaigns. A study that was conducted in the United States about the uptake of the Human Papilloma Virus (HPV) has shown that individuals' engagement with anti-vaccine messages on social media has a negative impact on their intentions to get vaccinated [58] . Literature on health communication has shown that emphasizing the benefits of partaking in health behavior rather than portraying the harms of refusing to take the health behavior and focusing on the immediate and personalized benefits rather than distant societal benefits are more effective in delivering health promotion messages [59] . The belief that the decision to get vaccinated should not be based on religious or cultural beliefs positively influenced the willingness to receive the COVID-19 vaccine. Some literature related religiosity with less willingness to receive the vaccine; however, during the current pandemic, many religious institutions encouraged people to become vaccinated, playing the expected role in influencing people's choices in a positive way [60, 61] . Past experience with the influenza vaccine was also a predictor of willingness to get the COVID-19 vaccination. In Palestine, getting the influenza vaccine is optional in all settings, including health care facilities and clinical training programs. Thus, participants who had received the influenza vaccine before exhibited a more positive attitude towards vaccination in general. This study highlights the need to design a specific curriculum in dental professional training about infectious disease, immunity, and vaccines in addition to public health to enhance knowledge and improve attitudes towards vaccines in general. It also indicates the necessity of building trust between the government, the pharmaceutical industry, and students in healthcare professions. This can be done by arranging meetings and information sessions for students and professionals demonstrating policies related to pandemics and vaccines and speaking openly about the effectiveness and safety of new vaccines. If dental students, among others in healthcare teams, have positive attitudes towards vaccines, it is hoped that they will share their experiences with patients, family, and friends to encourage vaccine uptake. In the COVID-19 pandemic, many countries are advocating support of dentists administering vaccines to patients to accelerate vaccine rollout during pandemics [51] . Adequate knowledge, trust, and positive attitudes are necessary to make dental students, the future dentists, ready to be part of the healthcare team advocating and recommending receiving vaccines, in general. Although the current study targeted all dental schools in the occupied Palestinian territories through their FB official social media pages, participants who did not respond to the current survey might have been hesitant to be vaccinated, which can underestimate the true prevalence of vaccine hesitancy among Palestinian dental students. Additionally, the lack of a comparison group of students from different educational backgrounds, such as non-health profession students, limited the ability to assess the influence of the dental professional training on students' willingness to get the vaccine. However, the progression among academic years from first year to senior year did not influence participants' decision, which gives an indication that the type of education was not a major player in our current sample responses. Although the use of official students FB groups is very effective to reach students in Palestinian universities, selection bias in the current study can limit the generalizability of our results. Another limitation of the current study design is that the associations among our variables are bidirectional, which makes our statistical model more a descriptive than predictive. Data collection in the current study was done before vaccination campaigns started, thus first-hand experience with the vaccine was not established yet in these communities. Dental students' main exposure to information related to the new vaccine was predominantly influenced by media and politics, as these topics had not been included in students' dental professional training yet. In general, reporting willingness to receive the vaccine might not translate to real behavior, so we cannot predict whether those who indicated they would receive the vaccine will actually follow through. A future study that follows up on the real behavior of vaccination uptake in this population might validate the current study findings. In conclusion, the majority of dental students in Palestinian educational institutions were willing to get vaccinated again COVID-19 when it becomes available to them. However, the negative attitude towards new vaccines, in general, may stem from inadequate information about the favorable risk-benefit ratio of vaccines and the natural immunity vs. the vaccine immunity and the mistrust in pharmaceutical industry transparency, which were all barriers for our sample' willingness to get vaccinated. Adequate information about vaccines, their risk-benefit ratios, and natural and acquired immunity are important to build trust and favorable attitudes towards vaccines among dental students. 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Front Ramadan and COVID-19 vaccine hesitancy-A call for action Intention to Vaccinate Against the Novel 2019 Coronavirus Disease: The Role of Health Locus of Control and Religiosity Acknowledgments: This work is dedicated to the more than 3 million worldwide fatalities and their families who have fallen victim to COVID-19. The authors would like to thank the members of the Standing Committee on Research and Education (SCORE) of the International Association of Dental Students (IADS). In addition, they would like to thank the members of the Palestinian Association of Dental Students (PADS) who helped in the data collection for the current study. The authors declare no conflict of interest.