key: cord-0988334-lr088ier
authors: Giammarco, Sabrina; Chiusolo, Patrizia; Sica, Simona; Rossi, Monica; Minnella, Gessica; Zini, Gina
title: Sudden death of a SARS‐CoV‐2 patient with NPM1 + acute myeloid leukemia mimicking acute promyelocytic leukemia
date: 2021-01-26
journal: Int J Lab Hematol
DOI: 10.1111/ijlh.13446
sha: 66acfce1a0479f9808d2dce384fb56f95272a2ca
doc_id: 988334
cord_uid: lr088ier

nan

To the Editor, NPM1-mutated de novo acute myeloid leukemia (AML) is a heterogeneous group of disorders, including forms with monocytic or myeloid morphology and immunophenotype and several different comutational patterns. Recently, a new subset was described:

It shows an APL-like immunophenotype, with negativity for both CD34 and HLA-DR, in the absence of a PML-RARA transloca- It must take into account in differential diagnosis. Sudden death due to a major bleeding was unexpected in a young man, with no comorbidities, and with moderate thrombocytopenia and elevated D-dimer level, in the absence of overt DIC The SARS-CoV-2 infection possibly contributed to the general symptoms of our patient and played a significant role in the onset of overt DIC and intracranial bleeding, as previously reported. 3

The authors have no competing interests.

The data that support the findings of this study are available from the corresponding author upon reasonable request.

https://orcid.org/0000-0002-1382-5496

Patrizia Chiusolo https://orcid.org/0000-0002-1355-1587

Gina Zini https://orcid.org/0000-0003-0782-294X

A distinct immunophenotype identifies a subset of NPM1-mutated AML with TET2 or IDH1/2 mutations and improved outcome

Blast phenotype and comutations in acute myeloid leukemia with mutated NPM1 influence disease biology and outcome

Haematological manifestations, mechanisms of thrombosis and anti-coagulation in COVID-19 disease: a review