key: cord-0995432-ytn1i8f7
authors: Viana‐García, Alba; Pina‐Belmonte, Adela; Salavert‐Pamblanco, Sofia; Atienza‐Garcia, Angel
title: Multisystemic inflammatory syndrome in a young adult after SARS‐CoV‐2 infection: Case report
date: 2021-05-24
journal: J Med Virol
DOI: 10.1002/jmv.27083
sha: f21456df3573db438b7efcf95d53698cf131df70
doc_id: 995432
cord_uid: ytn1i8f7

SARS-CoV-2 infection may precede the appearance of dysregulated immune responses adopting form of multisystemic inflammatory syndrome in adults (MIS-A), that can be fatal because of end-organ damage. We present a case report of a 24-years-old women with MIS-A in the setting of preceding SARS-CoV-2 infection. Early treatment prevented the development of end-organ damage and allowed rapid recovery. This article is protected by copyright. All rights reserved.

Recent studies suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may precede the appearance of dysregulated immune responses, adopting the form of the multisystemic inflammatory syndrome in adults (MIS-A), as previously described in children (MIS-C). 1 In this paper is presented the case of a 24-year-old Hispanic woman with a record of persistent positivity for lupus anticoagulant at moderate titers, without previous thrombotic or obstetric events, that was admitted to the hospital after 4 days of fever, headache, odynophagia, bilateral cervical painful lymphadenopathies, abdominal pain, nausea, vomiting, and diffuse exanthema.

The patient had experienced a recent SARS-CoV-2 infection, properly confirmed by a polymerase chain reaction (PCR) swab test 20 days before the admission. Her symptoms consisted of cough, myalgias, and odynophagia, and were solved within 14 days.

Vital signs at admission were: arterial pressure 115/55 mmHg, heart rate 100 bpm, 98% oxygen saturation at 98% with no oxygen supply, and a temperature of 38.5°C. Examination revealed hyperemic pharynx, left cervical and submandibular painful lymphadenopathies, and nonpruriginous maculopapular exanthema, nonpruriginous, which involved affecting trunk and extremities and sparing palms and soles. The rest of the exploration was normal.

Laboratory tests (Table 1) The diagnosis of MIS-A requires expertise, given its high similarity to other clinical syndromes that also require urgent attention, such as sepsis or toxic shock syndrome. MIS-A can be fatal due to end-organ damage; therefore, early detection and immediate initiation of therapy are crucial to achieve a successful recovery. 

Case series of multisystem inflammatory syndrome in adults associated with SARS-CoV-2 infection-United Kingdom and United States

The Centers for Disease Control and Prevention (CDC) Health Alert Network. Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus Disease

Hyperinflammatory shock in children during COVID-19 pandemic

An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study