key: cord-1003663-9931jc8r
authors: Takuva, Simbarashe; Takalani, Azwidhwi; Garrett, Nigel; Goga, Ameena; Peter, Jonny; Louw, Vernon; Opie, Jessica; Jacobson, Barry; Sanne, Ian; Gail-Bekker, Linda; Gray, Glenda
title: Thromboembolic Events in the South African Ad26.COV2.S Vaccine Study
date: 2021-06-02
journal: N Engl J Med
DOI: 10.1056/nejmc2107920
sha: 1ebfb968b0c1f7e3f9164c09bb6b40ee53722276
doc_id: 1003663
cord_uid: 9931jc8r

nan

64-year-old woman who received a diagnosis of cor pulmonale 17 days after vaccination; this case had features consistent with chronic and recurrent pulmonary emboli. Two cerebrovascular accidents (infarcts on imaging) were reported -one case involved a 45-year-old woman who had underlying rheumatic heart disease and a history of human immunodeficiency virus infection, cerebrovascular accident, and aortic valve replacement, in whom left-sided weakness developed the day after vaccination, and the other case involved a 38-year-old woman who had given birth to twins 9 months before vaccination and presented with features of transient ischemic attack 8 days after vaccination. A 65-year-old woman with chronic diabetes mellitus had deterioration and blurring of vision 8 days after vaccination and received a diagnosis of retinal vein occlusion and macular hemorrhage. To date, no case of vaccine-induced immune thrombotic thrombocytopenia has been documented.

In South Africa, since the start of the pandemic, Covid-19 has been reported in 1.58 million persons, including more than 55,000 health care workers. The rate of adverse events with vaccination is low, and thromboembolic events have occurred mainly in persons with risk factors for thromboembolism.

Pathologic antibodies to platelet factor 4 after ChAdOx1 nCoV-19 vaccination

Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination

Priority list of COVID-19 adverse events of special interest: quarterly update 2_v1.2. Safety Platform for Emergency vACcines

Safety reporting during clinical trials in South Africa

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