key: cord-1012497-vley73hp
authors: Rashedi, Jalil; Mahdavi Poor, Behroz; Asgharzadeh, Mohammad
title: Sodium Bicarbonate Nebulized Therapy in Patients with Confirmed COVID-19
date: 2020-10-14
journal: Adv Pharm Bull
DOI: 10.34172/apb.2021.047
sha: 323d19e9a7d3685498bd4ecbb0ba46ebff5b7da9
doc_id: 1012497
cord_uid: vley73hp

nan

. Assumed pathway of endocytosis of SARS-CoV-2 into the target cells with Sodium bicarbonate (right pathway) and without it (left one). Binding of the virus S-protein to ACE2 promotes internalization into endosomes, where the low pH environment triggers fusion activity in the S-protein. Inhibitors of acidification, such as NaHCO 3 , CLQ/CLQ-OH, NH 4 Cl or BAF can be used to dissect the pathway because they specifically block pH-dependent membrane fusion.

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