key: cord-1019197-llub5c9r authors: Merkoçi, Arben; Li, Chen-zhong; Lechuga, Laura M.; Ozcan, Aydogan title: COVID-19 Biosensing technologies date: 2021-01-28 journal: Biosens Bioelectron DOI: 10.1016/j.bios.2021.113046 sha: 05d1b12019f917405a6aae3ab17089e7aca22546 doc_id: 1019197 cord_uid: llub5c9r nan Everyone from clinical doctors to citizens staying at home still needs COVID-19 diagnostics devices that fulfil the requisites established by the World Health Organization as ASSURED: affordable, sensitive, specific, user-friendly, rapid and robust, equipment free, and deliverable to end-users. Biosensors are at the heart of various rapid and essential diagnostic tools for providing accurate and timely guidance for case identification, prevention of the spread of infectious diseases, and appropriate treatment administration. Moreover, it is expected that biosensor technologies will be employed not only for rapid coronavirus infection diagnosis in humans but also as a global screening tool for surveillance, prevention, and preparedness in the event of future outbreaks. This special issue dedicated to COVID-19 biosensing technologies showcases the noble efforts of scientists and engineers working on new technologies capable of detecting COVID-19 related biomarkers in clinical and/or environmental samples. Included are several important reviews related to the impact of biosensing in the COVID-19 pandemic outbreak i , the potential application of electrochemical biosensors ii or other types of biosensors iii , iv , v , vi , vii , viii , ix , clinically tested and commercially available devices x, and the use of graphene-based approaches xi for virus detection. In addition to review papers, this special issue includes a broad range of biosensor technologies applied to COVID-19 diagnostics. Several applications using lateral flow devices are published, demonstrating the advantages of paper-based platforms in terms of cost and efficiency xii , xiii , xiv , xv . Furthermore, this issue includes research articles related to new strategies for COVID-19 biosensors by integration of the CRISPR-Cas system, which is expected to foster a new generation of biosensors for point of care testing (POCT) xvi , xvii , xviii . This issue includes several research articles covering various electrochemical techniques combined also with nanosystems and magnetic particles engineered to detect COVID19 biomarkers xix , xx , xxi , xxii . This special issue also includes several highly sensitive optical methods for SARS-CoV-2 detection using techniques based on nanoplasmonics xxiii , optomicrofluidics xxiv , quenching xxv , magnetooptics xxvi and even a hybrid opto/electrochemical method xxvii . Finally, given the importance of real-time monitoring of COVID-19 studies, this issue also reports a computational simulation platform xxviii as well as detection of airborne coronavirus and influenza virus xxix . According to WHO reports, in the last 10 years, we have witnessed more than 5 world-wide epidemic diseases, namely severe acute respiratory syndrome (SARS), swine flu, Ebola, Middle East respiratory syndrome (MERS), Zika, and coronavirus disease 2019 . Consequently, POCT biosensor devices will play more and more critical roles not only in rapid "on-site" detection but also in preventing the transmission of infectious diseases. Research and development efforts will continue to support these POCT devices through the technological developments in biosensors and IoT, seeking to achieve wireless based operation and connectivity with health experts and health care facilities. Considering the high demand as well as the tremendous ongoing research for high throughput and rapid COVID-19 testing, the editorial board of the journal of Biosensor and Bioelectronics, has decided to extend this special issue on COVID biosensing to a 2 nd edition focusing on original research of innovative integrated biosensing systems for COVID-19 prevention, diagnosis, and prognosis. i The impact of biosensing in a pandemic outbreak: COVID-19, Eden Morales-Narváez, Can Dincer ii The potential application of electrochemical biosensors in the COVID-19 pandemic: A perspective on the rapid diagnostics of SARS-CoV-2, Sahar Sadat Mahshid iii Developments in biosensors for CoV detection and future trends, Riccarda Antiochia iv COVID-19 diagnosis -A review of current methods, Meral Yüce, Elif Filiztekin, Korin Gasia Özkaya vi Facile biosensors for rapid detection of COVID-19 vii Detection of COVID-19: A review of the current literature and future perspectives viii Diagnostics for SARS-CoV-2 detection: A comprehensive review of the FDA-EUA COVID-19 testing landscape ix Diagnostic methods and potential portable biosensors for coronavirus disease 2019 x Clinically practiced and commercially viable nanobio engineered analytical methods for COVID-19 diagnosis xii Dual lateral flow optical/chemiluminescence immunosensors for the rapid detection of salivary and serum IgA in patients with COVID-19 disease xiii A novel rapid detection for SARS-CoV-2 spike 1 antigens using human angiotensin converting enzyme 2 (ACE2) xiv Enhancing performance of paper-based electrochemical impedance spectroscopy nanobiosensors: An experimental approach xv Multiplex reverse transcription loop-mediated isothermal amplification combined with nanoparticle-based lateral flow biosensor for the diagnosis of COVID-19 One-pot visual RT-LAMP-CRISPR platform for SARS-cov-2 detection, Rui Wang, Chunyan Qian, Yanan Pang xvii Point-of-care CRISPR/Cas nucleic acid detection: Recent advances, challenges and opportunities xviii Ultra-sensitive and high-throughput CRISPR-p owered COVID-19 diagnosis xix Ultra-sensitive viral glycoprotein detection NanoSystem toward accurate tracing SARS-CoV-2 in biological/non-biological media xx Rapid detection of SARS-CoV-2 antibodies using electrochemical impedance-based detector xxi Magnetic beads combined with carbon black-based screen-printed electrodes for COVID-19: A reliable and miniaturized electrochemical immunosensor for SARS-CoV-2 detection in saliva ROS) in fresh sputum by electrochemical tracing; correlation between COVID-19 and viral-induced ROS in lung/respiratory epithelium during this pandemic xxiii One-step rapid quantification of SARS-CoV-2 virus particles via low-cost nanoplasmonic sensors in generic microplate reader and point-of-care device xxiv Detection of antibodies against SARS-CoV-2 spike protein by gold nanospikes in an opto-microfluidic chip xxv DNA nanoscaffold-based SARS-CoV-2 detection for COVID-19 diagnosis xxvi Homogeneous circle-to-circle amplification for real-time optomagnetic detection of SARS-CoV-2 RdRp coding sequence xxvii G-quadruplex based biosensor: A potential tool for SARS-CoV-2 detection xxviii A computational simulation platform for designing real-time monitoring systems with application to COVID-19 Hyeong Rae Kim, Sanggwon An, Jungho Hwang