key: cord-1022756-7ilqwnxp
authors: Zengarini, Corrado; Piraccini, Bianca Maria; La Placa, Michelangelo
title: Lichen Ruber Planus occurring after SARS‐CoV‐2 vaccination
date: 2022-02-26
journal: Dermatol Ther
DOI: 10.1111/dth.15389
sha: 7e53d10cde04c927fad23c114bb509022a8817ef
doc_id: 1022756
cord_uid: 7ilqwnxp

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He did not report any additional symptoms. The past medical history is silent, and he has not taken drugs in chronic nor in a discontinuous manner in the last year.

When examined, the patient presented erythematous papules on the upper and lower limbs, while on the feet formed small plaques with a keratotic centre. No other lesions were found on oral and genital mucosa ( Figure 1A The onset of LP after vaccination in our patient may have multiple pathogenetic mechanisms. Among these, we believe that T-cells play an essential role in the immune response against the cells of the basal layer of the skin in predisposed patients due to the increase in circulating pro-inflammatory cytokines induced by the vaccine response. 8 Another mechanism may be reconducted to ACE-2 receptors in the skin. 9 Spike proteins generated by the vaccine may link to the cutaneous cells presenting this receptor and start an immune response by recruiting CD4+ lymphocytes, eventually causing LP in predisposed subjects.

While considering that any inflammatory stimulus, such as vaccinations, can act as a potential trigger of autoimmune disease, such LP in predisposed subjects, data currently do not contraindicate future Anti-Sars-Cov2 vaccinations of any type in this kind of patients.

We conclude with a reminder for dermatologists and practitioners to continue investigating any onset of clinical signs F I G U R E 1 (A) detail of the Lichen of the right foot; (B) Papules of the right arm; (C) Whickam striae, characteristics of lichen planus, observed at Dermoscopy

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