key: cord-1024900-gazmw8gg authors: Abool Maaly, Cheikh A.; Al Suwaidi, Jassim; Khatib, Mohamad Yahya; Alzaeem, Hakam title: Right Atrial Thrombus in Transient in a COVID-19 Patient: Clinical Echocardiographic Features—Case Report and Literature Review date: 2020-10-08 journal: SN Compr Clin Med DOI: 10.1007/s42399-020-00568-7 sha: 13a9a98563fb2e4348ed3b38aacf7109bc19639f doc_id: 1024900 cord_uid: gazmw8gg A 54-year-old male is admitted with COVID-19 pneumonia and received prophylactic anticoagulation. On day 8, the patient rapidly deteriorated requiring urgent endotracheal intubation. Transthoracic echocardiography revealed large right atrial thrombus in transient, resulting in pulmonary embolism and severe RV failure; fibrinolytic therapy was not effective and the patient passed away. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s42399-020-00568-7) contains supplementary material, which is available to authorized users. A 54-year-old male presented to the emergency department with history of fever and nonproductive cough for 1-day duration; on presentation, he was afebrile, and the patient's heart rate is 88 beats/min, respiratory rate 16/min, and blood pressure was 154/ 96 mmHg. The patient had normal arterial oxygen saturation (SaO 2 ) 98% on room air. Physical examination demonstrated coarse crackles in the bilateral lower lung fields. Laboratory results throughout hospitalization are shown in Table 1 . The electrocardiogram on admission showed normal sinus rhythm; chest X-ray showed bilateral patchy infiltration. He was treated with oral amoxicillin/clavulanic acid (625 mg q8 h, azithromycin (500 mg daily), hydroxychloroquine (400 mg BID), paracetamol (1000 mg TID), and subcutaneous enoxaparin (40 mg once daily). The patient's fluorescence polymerase chain reaction result for SARS-CoV-2 returned positive. On the second day of admission, the patient's fever subsided and his overall symptoms improved. On admission day 5, the patient became hypoxic with oxygen saturation of < 90% requiring supplemental oxygen inhalation initially with oxygen inhalation by non-rebreather mask at the rate of 8 l/min, which was subsequently increased to 10 l/min. On day 8, the patient suddenly developed profound hypotension and had severe desaturation requiring urgent endotracheal intubation. While D-dimer remained normal until day 8, the inflammatory parameters were progressively increasing ( Table 1) . Urgent bedside transthoracic echocardiography (TTE) revealed large transient thrombi in the right atrium (RA) and right ventricular (RV) with McConnell's sign and severe RV failure (see videos). Patient urgently received fibrinolytic therapy (alteplase 100 mg) without any significant improvement while preparations are underway for VA-ECMO; unfortunately the patient had cardiac arrest and subsequently passed away. Since December 2019, the COVID-19 outbreak has spread worldwide. Around 14% of cases are reported to have severe symptoms and 5% of patients developed respiratory failure, shock, and multi-organ failure. A strong correlation of COVID-19 and hypercoagulopathy has been confirmed in ICU and non-ICU COVID-19 patients [1] , particularly those with limited mobility and high levels of inflammatory markers [2] . Different mechanisms contributed to the pathogenesis of hypercoagulopathy in COVID-19 disease including stasis, endothelial injury, and coagulation abnormalities such as elevated D-dimer, fibrinogen, von Willebrand factor (VWF) antigen, and factor VIII activity [3] . A retrospective study showed that microvascular pulmonary thrombosis in patient with COVID-19 pneumonia was not influenced by preadmission treatment with anti-thrombotic therapy which may indicate a complex interplay between SARS-CoV-2 and clotting system activation [4] . The first case of COVID-19 complicated by massive pulmonary embolism (PE) and RV failure was published in JACC April 2020 [5] . Later on, many cases were reported and vast majority of them were diagnosed using computerized tomography (Table 2) . To the best of our knowledge, our case is one the first few cases of COVID-19 complicated by pulmonary embolism diagnosed by echocardiography [11, 12] . Transthoracic echocardiography is more convenient as it can be performed bedside immediately without the need to move the patient. Moreover, as far as we know, this case is one of the few cases that has developed fatal thromboembolism despite being on anticoagulants [13] and having normal D-dimer level on presentation until the day of event; this might suggest the need of higher doses of prophylactic anticoagulants in patients with severe COVID-19 pneumonia even with normal D-dimer. Fatal thrombosis may develop in patients with severe COVID-19 pneumonia despite prophylactic anticoagulation; therefore, more evidence is needed for identification of these high-risk patients and the proper doses of prophylactic anticoagulants. • To stress on the potential role of transthoracic echocardiography as a quick and widely available tool to help in the diagnosis of pulmonary embolism in COVID-19 patients • To question the proper dosage of prophylactic anticoagulation in COVID-19 patients Funding Open Access funding provided by the Qatar National Library. Conflict of Interest None. 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COVID-19 and pulmonary embolism: not a coincidence COVID19: a case report of thrombus in transit Clot in transit on transesophageal echocardiography in a prone patient with COVID-19 acute respiratory distress syndrome. CASE (Philadelphia, Pa.) Late pulmonary embolism after COVID-19 pneumonia despite adequate rivaroxaban treatment Electronic supplementary material The online version of this article (https://doi.org/10.1007/s42399-020-00568-7) contains supplementary material, which is available to authorized users.