key: cord-1026474-3k8b7sde authors: Melo, M. S. d.; BORGES, L. P.; SOUZA, D. R. V.; MARTINS, A. F.; NETO, J. M. D. R.; RIBEIRO, A. A.; SANTOS, A.; INVENCAO, G. B. D.; MATOS, I. L. S.; SANTOS, K. A. D.; SOUZA, N. A. A.; BORGES, P. C.; OLIVEIRA, M. G. B. D. title: Anti-SARS-CoV-2 IgM and IgG antibodies in health workers in Sergipe, Brazil date: 2020-09-25 journal: nan DOI: 10.1101/2020.09.24.20200873 sha: 7de664f0e89ba92fc34e9bc405f773a9a007404e doc_id: 1026474 cord_uid: 3k8b7sde Background: The exponential growth of COVID-19 cases in Brazil is overloading health systems with overcrowding of hospitals and overflowing intensive care units. Increasing infection rates in health professionals can lead to the collapse of the health system and further worsen the pandemic. The aim of this study was to evaluate the seroprevalence of IgM and IgG for SARS-CoV-2 in health workers in Sergipe, Brazil. Methods: The targeted tests involved health professionals working on the front line to combat COVID-19. The samples were collected in the month of June, in six hospital units in the state of Sergipe. Results: 471 health professionals were tested. Of these, 28 workers (5.95%) tested positive for IgM and 64 (13.59%) tested positive for IgG. 9 workers (1.91%) tested positive for IgM and were also positive for IgG. Discussion: Health workers must be monitored constantly, because if they are infected, they can spread the virus to colleagues, hospitalized patients and even family members. Conclusion: Knowing the prevalence of antibodies to the virus in health workers is an important measure of viral spread control. Keywords: SARS-CoV-2, COVID-19, Health workers, Immunofluorescence assays. The orientation of social isolation is not suitable for health workers who work directly 55 to confront COVID-19. Increased infection rates among health workers can lead to the 56 collapse of the health system and further worsen the pandemic (BARRANCO and 57 VENTURA, 2020). In this context, the objective of this study was to evaluate the is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprint The copyright holder for this this version posted September 25, 2020. is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprint The copyright holder for this this version posted September 25, 2020. . https://doi.org/10.1101/2020.09.24.20200873 doi: medRxiv preprint 4 detected in sera using an in vitro diagnostic test system based on lateral flow sandwich A total of 471 health workers were tested. Of these, 134 were from the Sergipe is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprint The copyright holder for this this version posted September 25, 2020. is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprint The copyright holder for this this version posted September 25, 2020. is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprint The copyright holder for this this version posted September 25, 2020. The study showed the prevalence of COVID-19 in health professionals in the state of is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprint The copyright holder for this this version posted September 25, 2020. . https://doi.org/10.1101/2020.09.24.20200873 doi: medRxiv preprint . CC-BY-NC-ND 4.0 International license It is made available under a perpetuity. is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprint The copyright holder for this this version posted September 25, 2020. is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprint The copyright holder for this this version posted September 25, 2020. . https://doi.org/10.1101/2020.09.24.20200873 doi: medRxiv preprint Covid-19 and infection in health-care workers: An emerging problem Real estimates of mortality following Covid-19 190 infection The global spread of 2019-nCoV: a molecular 193 evolutionary analysis Seroprevalence of SARS-CoV-2 IgM and IgG antibodies in an asymptomatic population in 196 Sergipe Diagnosis of Ebola Virus Disease: Past, Present, 199 and Future Optical techniques for fastscreening -towards prevention 201 of the coronavirus COVID-19 outbreak Clinical Validity of Serum Antibodies to 203 SARS-CoV-2: A Case-Control Study Rao 205 AK. Symptom Screening at Illness Onset of Health Care Personnel With SARS Antibody tests for identification of current and past 209 infection with SARS-CoV-2 SARS-Cov-2 infection: 211 Response of human immune system and possibleimplications for the rapid test and treatment Profiling Early Humoral Response to Diagnose Novel 214 Coronavirus Disease (COVID-19) Infectious Diseases Society of America 216 Guidelines on the Diagnosis of COVID-19: Serologic Testing Clinical features of patients infected with 2019 novel coronavirus 220 in Wuhan, China Rapid Decay of Anti-SARS-CoV-2 222 Antibodies in Persons with Mild Covid-19 Diagnostic value 224 and dynamic variance of serum antibody in coronavirus disease 2019 COVID-19 Testing in South Korea: Current Status and the 227 Need for Faster Diagnostics Preventing Transmission of Pandemic Influenza and Other Viral 232 Respiratory Diseases: Personal Protective Equipment for Healthcare Personnel: Update Assessment of immune response to SARS-CoV-2 with fully automated 237 MAGLUMI 2019-nCoV IgG and IgM chemiluminescence immunoassays Antibody responses to SARS-CoV-2 in patients with 240 COVID-19 Clinical and immunological assessment of asymptomatic 242 SARS-CoV-2 infections How Brazil can hold back COVID-19 Analytical performances of a 249 chemiluminescence immunoassay for SARS-CoV-2 IgM/IgG and antibody kinetics. Clinical 250 Chemistry and Laboratory Medicine Profile of IgG and IgM antibodies against severe acute respiratory 252 syndrome coronavirus 2 (SARS-CoV-2) The epidemiology and pathogenesis of coronavirus disease 254 (Covid-19) outbreak It is made available under a perpetuity.is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprintThe copyright holder for this this version posted September 25, 2020. . CC-BY-NC-ND 4.0 International license It is made available under a perpetuity.is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprintThe copyright holder for this this version posted September 25, 2020. . https://doi.org/10.1101/2020.09.24.20200873 doi: medRxiv preprint