key: cord-1027063-3mye4f24 authors: Pathak, Subodh Kumar; Pandey, Sanjay; Pandey, Apurva; Salunke, Abhijeet Ashok; Thivari, Praveen; Ratna, Harish V.K.; Chawla, Jasneet title: Focus on uncommon symptoms of COVID-19: Potential reason for spread of infection date: 2020-09-16 journal: Diabetes Metab Syndr DOI: 10.1016/j.dsx.2020.09.017 sha: d34384dd7d19025750ae9c21d2c35ddfaea1cb66 doc_id: 1027063 cord_uid: 3mye4f24 Focus on uncommon symptoms of COVID-19: Potential reason for spread of infection. The coronavirus disease 2019 (COVID-19) pandemic continues to spread with more than 27 4 million cases and more than 896 thousand deaths so far [1] . India has confirmed more than 42, 5 84,100 cases of COVID-19 so far, making it the world's second worst-hit country in terms of 6 number of cases and third in terms of total deaths [1] . Presence of comorbidities worsens the 7 outcome of disease and is associated with poor prognosis and increased mortality[2-5]. The 8 vaccine for the infection is in different phases of clinical trials and till then various drugs have 9 been tried with questionable effects[6-9]. SARS-CoV-2 infection can be asymptomatic or be 10 associated with COVID-19, which presents with spectrum of respiratory clinical manifestations 11 ranging from fever, dry cough, dyspnea, pulmonary edema, acute respiratory distress syndrome, 12 and multiple organ failures, requiring hospitalization in intensive care unit and leading to death 13 in severe cases. In the initial report of 138 patients from Wuhan, China, fever was present in 14 98.6%, dry cough in 60% and diarrhea and headache was present in 10% and 6% Literature has shown headache as the 5th most common COVID 19 symptom after fever, 22 cough, myalgia, and dyspnea [11] . Headache in COVID -19 has been shown to be present in 23 6.5% 53% of patients in recent studies [12, 13] . The striking features of the headache is sudden 24 to gradual onset and poor response to common analgesics, or high relapse rate, that was limited COVID-19 pandemic and challenges for socio-economic issues healthcare and National Health Programs in India COVID -19 in cancer patients on severity of disease and fatal outcomes: A systematic 73 review and meta-analysis Diabetes in COVID-19: Prevalence Comorbidities in COVID-19: Outcomes in hypertensive 79 cohort and controversies with renin angiotensin system blockers Hydroxychloroquine in patients with COVID-19: 82 A Systematic Review and meta-analysis Remdesivir in COVID-19: A critical review of 85 pharmacology, pre-clinical and clinical studies Role of corticosteroid in the management of 88 COVID-19: A systemic review and a Clinician's perspective No benefit of hydroxychloroquine in COVID-19: Results of Systematic 92 Review and Meta-Analysis of Randomized Controlled Trials Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan Novel Coronavirus Infection (COVID-19) in Humans: A Scoping 99 High 101 Prevalence of Headaches During Covid 19 Infection: A Retrospective Cohort Study Characteristics, Treatment Outcomes 104 and Role of Hydroxychloroquine among 522 COVID-19 hospitalized patients in Jaipur 105 City: An Epidemio-Clinical Study COVID-19 is a Real Headache Manifestations and prognosis of 109 gastrointestinal and liver involvement in patients with COVID-19: a systematic review 110 and meta-analysis Don't Overlook Digestive Symptoms in Patients With Coronavirus Disease (COVID-19) Anosmia as a prominent symptom of COVID-19 infection 119 Features of anosmia in COVID-19 Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 123 Infection: A Cross-sectional Study Loss of 126 smell and taste in combination with other symptoms is a strong predictor of COVID-19 127 infection Impact of COVID-19 and comorbidities on health and economics: 132 Focus on developing countries and India We intend to publish an article entitled "Focus on uncommon symptoms of COVID-19: Potential reason for spread of infection." in your esteemed journal.On behalf of all the contributors I will act and guarantor and will correspond with the journal from this point onward.