key: cord-1032644-mi208446 authors: Deniz, Rabia; Çağatay, Arif Atahan; Gül, Ahmet title: Letter: is pneumococcal vaccination safe during the COVID‐19 pandemic? date: 2020-08-14 journal: Aliment Pharmacol Ther DOI: 10.1111/apt.15903 sha: 4ddf2200dd34014231238114591db7a280d88e7c doc_id: 1032644 cord_uid: mi208446 LINKED CONTENT This article is linked to Al‐Ani et al papers. To view these articles, visit https://doi.org/10.1111/apt.15779 and https://doi.org/10.1111/apt.15940 Although immunisation of especially vulnerable populations has been shown to be protective for fatal bacterial complications in elective conditions, pneumococcal vaccination of a patient with a probable or existing COVID-19 during pandemic could cause a hyperinflammatory response by further activating the NLRP3-inflammasome and progression to the cytokine storm, ARDS and death. Therefore, because of the safety concerns, we consider that vaccination decisions, especially for pneumococcal vaccines, should be given very carefully during the pandemic until further data become available. Declaration of personal interest: None. Review article: prevention, diagnosis and management of COVID-19 in the IBD patient Coronavirus disease 2019 in elderly patients: characteristics and prognostic factors based on 4-week follow-up NLRP3 inflammasome -a key player in antiviral responses Relationships among lymphocyte subsets, cytokines, and the pulmonary inflammation index in coronavirus (COVID-19) infected patients Severe acute respiratory syndrome coronavirus viroporin 3a activates the NLRP3 inflammasome Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host Recognition of Streptococcus pneumoniae by the innate immune system Safety of vaccinations in patients with cryopyrin-associated periodic syndromes: a prospective registry based study