key: cord-1032718-sksvjxyg
authors: Mohanraj, Lathika; Elswick, R.K.; Buch, Molly; Knight, Jennifer M.; Guidry, Jeanine
title: Perceptions and Experiences of Hematopoietic Cell Transplantation Patients During the COVID-19 Pandemic
date: 2022-03-10
journal: Semin Oncol Nurs
DOI: 10.1016/j.soncn.2022.151257
sha: 9965d142ef3666454fb9666f84090a75c2fc4cc4
doc_id: 1032718
cord_uid: sksvjxyg

OBJECTIVES: : Since March 2020, the severe acute respiratory syndrome coronavirus-2 pandemic has affected the global community, but poses unique challenges for individuals with cancer. Patients diagnosed with hematologic malignancies undergo aggressive therapies followed by hematopoietic cell transplantation (HCT) as a potential curative treatment. HCT recipients can be immunocompromised for extended periods of time, and even pre-pandemic, transplant patients reported depression and anxiety due to restrictions and infection prevention measures they had to adhere to as part of transplant precautions. This study aimed to understand psychological distress and capture perspectives on coping strategies and access to healthcare in the HCT population during the COVID-19 pandemic. DATA SOURCES: : Adult patients who received a transplant or were awaiting transplant and had a scheduled appointment at the transplant clinic were eligible to participate in this cross-sectional study. Participants completed an online survey that included questionnaires, clinical data and demographic information. CONCLUSION: : Fifty-four participants completed the survey. HCT participants reported relatively high psychological distress during the initial phase of the COVID-19 pandemic, but indicated use of healthy coping mechanisms to deal with stress. IMPLICATION FOR NURSING PRACTICE: : Study data informs healthcare providers that psychological distress and mental health warrants increased attention during periods of heightened stress. Education and resources on healthy, beneficial coping strategies should be provided to support HCT patients. Nurses and advanced nurse practitioners are well poised to interact with HCT patients and provide necessary support or appropriate referral during routine clinical interactions, preparing patients for prolonged effects of the pandemic and similar future events.

they had to adhere to as part of transplant precautions. This study aimed to understand psychological distress and capture perspectives on coping strategies and access to healthcare in the HCT population during the COVID-19 pandemic.

Data Sources: Adult patients who received a transplant or were awaiting transplant and had a scheduled appointment at the transplant clinic were eligible to participate in this cross-sectional study. Participants completed an online survey that included questionnaires, clinical data and demographic information.

Conclusion: Fifty-four participants completed the survey. HCT participants reported relatively high psychological distress during the initial phase of the COVID-19 pandemic, but indicated use of healthy coping mechanisms to deal with stress. Implication for Nursing Practice: Study data informs healthcare providers that psychological distress and mental health warrants increased attention during periods of heightened stress.

Education and resources on healthy, beneficial coping strategies should be provided to support HCT patients. Nurses and advanced nurse practitioners are well poised to interact with HCT patients and provide necessary support or appropriate referral during routine clinical interactions, preparing patients for prolonged effects of the pandemic and similar future events.

Keywords hematopoietic cell transplantation, pandemic, distress, coping, COVID-19

In the midst of March 2020, the World Health Organization (WHO) declared the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) a public health emergency. 1 As of October 2021, there were over 240 million coronavirus cases and close to 5 million deaths globally, with over 92 million cases and nearly 2 million deaths within the United States alone. 2 SARS-CoV-2 belongs to the coronavirus family of viruses and varies in its severity from mild symptoms to severe complications such as severe acute respiratory distress syndrome, acute renal failure, septic shock and severe pneumonia. 1, 3 The pandemic has affected the livelihood and well-being of the global community; however, it is vital to acknowledge that certain populations such as the elderly, individuals with comorbidities, and immunocompromised individuals are at increased risk of and more susceptible to the disease. 4 Patients with cancer are usually immunocompromised either due to their diagnosis or corresponding treatment and are at an increased risk of infection compared to the general population. A position statement from the American Society of Clinical Oncology (ASCO) on the pandemic states that cancer patients are at a risk of increased mortality if infected with coronavirus disease-2019 (COVID-19) when compared to those without cancer. 5 When compared to those without blood cancers, patients diagnosed with hematologic malignancies report increased severity of COVID-19 and a higher mortality rate. 6, 7 For patients with a hematologic malignancy (e.g. multiple myeloma, leukemia, lymphoma), hematopoietic cell transplantation (HCT) is a potentially curative treatment.

Approximately 22,000 HCTs are performed annually in the US, 8 with its use and indications continuing to increase. During the process of HCT, these patients receive aggressive therapies, whereby following transplant they can be immunocompromised for extended periods of time, increasing their risk for contracting infections due to immunosuppressive regimens and transplant related complications. 9 In addition to this, psychological distress can have a significant negative impact on health outcomes, recovery, and function in HCT patients, leading to mortality and other severe transplant related effects. 10 HCT patients experience depression, anxiety and stress throughout the HCT process. Even prior to COVID-19, transplant patients reported experiencing depression and anxiety due to restrictions and infection prevention measures that they had to adhere to in preventing opportunistic infections and post-transplant complications. 11 Ongoing distress during the transplant process increases their risk for mortality. 12 Patients use various strategies to deal with stress and certain coping strategies (e.g., resignation), are associated with depression and anxiety pre-HCT. 12 In general, the pandemic lead to changes in access to healthcare and a rapid uptake of telemedicine in various clinical settings and populations including cancer patients. 13 The American Society for Transplantation and Cellular Therapy also provided guidelines stating that visits that are not critical should be either deferred or substituted with telemedicine as appropriate. 14 It is important to understand HCT patient's experience with access to healthcare, especially since these patients are seen frequently in the transplant clinic for their routine, Given the unique challenges faced by the HCT population during the COVID-19 pandemic, it is important to understand experiences and perspectives of this patient population. This descriptive study in HCT patients was designed to determine levels of distress, anxiety, and depression; capture perspectives on coping strategies; and understand patient experiences with access to healthcare and resources during the COVID-19 pandemic.

Study Design: This pilot study employed a descriptive, cross-sectional study design using a convenience sample of HCT eligible patients or HCT recipients. This study was conducted using online surveys on the Qualtrics platform.

Setting and Participants: HCT patients were recruited from the Cellular Immunotherapies and Transplant (CIT) program at a large mid-Atlantic research university. Adult patients 18 years of age and who have received a transplant or are awaiting transplant and were scheduled to be seen in the clinic (in person and via telehealth) were eligible to participate in the study.

Recruitment Procedures: The study was approved by the university's Institutional Review Board. Participants were recruited from May 2020 through October 2020. The study team sent potential participants an invitation to participate in the study with a link to the survey. The study link sent via email provided a description of the study and gave patients the opportunity to provide consent for the study. PROMIS anxiety: The PROMIS anxiety was used to measure anxiety and features eight statements associated with anxiety, with each response on a Likert scale from 0-5: 0 being 'never' and 5 being 'always'. This measure has been widely used and has demonstrated high reliability and consistent psychometric properties with a Cronbach's alpha of 0.95. 17 PROMIS depression: The PROMIS depression was used to measure depression and features eight statements associated with depression, with each response on a Likert scale from 0-5: 0 being never and 5 being always. This instrument has been widely used and is reliable and valid with a Cronbach's alpha of 0.95. 17, 18 Brief COPE: The Brief Coping with Problems Experienced (Brief COPE) questionnaire was used to assess coping strategies that were used by the participants. Eight different domains were assessed and each domain comprised of two questions rated on a 4-point Likert scale with total scores from 2-8 as a continuous variable (higher scores denoting more frequent use). The instrument has good construct, concurrent, and predictive validity in relation to emotional wellbeing and adjustment in different clinical populations including cancer patients. [19] [20] [21] Daily Inventory of Stressful Events (DISE): Participants were asked to appraise the extent to which COVID-19 pandemic as a stressor impacted certain aspects of their life on a 4-point scale from "none at all" to "a lot.". 22 This measure was not used in its entirety for this study.

Distress thermometer (DT): The Distress thermometer is a self-report measure to assess the level of distress patients may have experienced. The scale measures distress on a scale from 0-10, with 0 being no distress and 10 being extreme distress. This is an extensively used and validated measure in cancer patients. 23, 24 It has a problem list which is an inventory of issues that could have attributed to the distress experienced. The problem list was modified for purposes of this study wherein the patient answered "yes/no" to indicate the type of problem experienced since the pandemic.

Access to health care and resources: The survey had 4 questions related to changes in scheduled procedures and access to medical care, and the participants responded "yes/no" to indicate their experience. Two questions related to impact of pandemic on transportation and caregiver support were included on the survey, wherein participants responded on a 5-point scale from "strongly disagree" to "strongly agree".

Telemedicine: HCT participants were asked questions about their televisit preferences, wherein participants responded on a 5-point scale from "very unlikely" to "very likely".

Susceptibility and pandemic recommendations adherence: The survey included questions on the extent to which HCT participants were worried about family and self-susceptibility to COVID- 19 . The questions were rated on a 5-point scale from "not at all worried" to "extremely worried". Data Analysis: Descriptive statistics were run for all data to assess quality assurance and describe distributions. The survey and demographic data were descriptively analyzed (means/variances for continuous variables and frequencies/percentage for categorical variables).

Demographic information and clinical variables are presented in Table 1 PROMIS anxiety and depression.

The mean for anxiety was 13.67 (SD 5.86) and 45% of participants stated that the pandemic contributed to their anxiety levels. The mean for depression score was 12.50 (SD 5.02), 37% of participants attributed their depression to be impacted by the pandemic (Table 2) .

The mean score of all domains in the Brief COPE scale are shown in Table 2 . Coping domains can be divided into two major categories: approach coping (active coping, positive reframing, planning, acceptance, emotional support, and seeking informational support) and avoidant coping (denial, substance use, venting, behavioral disengagement, self-distraction and selfblame). 25 In the current study, patients endorsed utilizing acceptance, religion and positive reframing (approach coping) more often, and conversely endorsed utilizing substance use, denial and behavioral disengagement (avoidant coping) less frequently.

Participants were asked to indicate the extent to which the pandemic impacted their health, future plans, daily routine, health of loved ones, and financial situation as well as others' perception about them. Approximately 40% of HCT participants stated that the pandemic significantly impacted their health and future plans, and 35% indicated that the pandemic disrupted their daily routine 'a lot'. The frequencies for the DISE-stress appraisal measure are presented in Figure 1 .

The mean distress score in this study population was 3.22 (SD 2.49). Respondents indicated issues contributing to their distress under three main categories: practical problems, cognitive effects and social effects. Table 3 lists responses for all three categories. Eighty percent of the participants agreed that their 'ability to socialize' was a practical concern and 54% participants stated that 'ability to perform usual physical activity' was a physical concern attributing to their distress. Among cognitive effects, 56% and 48% of the participants agreed that 'worry' and 'fear' respectively contributed to their distress. 'Family health problems' was reported as a social issue contributing to distress by 35% of the participants. (Table 3 ) For the current crosssectional study involving HCT patients at different points in their transplant process a clinical cut-off of 3 was considered since it is an optimal cut off score in adult cancer patients where DT scores significantly differ at different time points during the treatment trajectory. 26 Access to healthcare and resources.

The pandemic resulted in changes in access to healthcare with specific restrictions in place to address the spread of the COVID-19 infection. 27 Participant responses regarding access to healthcare and other resources such as transportation and caregiver support are summarized in Table 4 . Twenty-eight percent of participants stated that they received less medical care (routine clinic visits or preventive care appointments) than usual; however, 98% of the participants stated that they were able to access medical care for a transplant-related complication. Eighteen percent of the participants had their medical procedures such as chemotherapy, surgery or stem cell collection postponed; 13% had their medical procedures canceled. Approximately one-third of the participants agreed that they hesitated to go the medical provider due to fear of COVID-19. Only 6% of the participants experienced an impact on transportation for transplant-related care and visits. Less than 10% participants stated that the pandemic impacted the ability of their caregivers to provide the required support and care.

Telemedicine.

During the initial phase of the pandemic, many healthcare settings transitioned to online models of care and established televisits to incorporate necessary pandemic related preventative measures and to reduce exposure of individuals to the hospital setting. 83% of individuals were likely to participate in televisits with their provider during the pandemic and 67% were likely to participate even after the COVID-19 pandemic.

Susceptibility and pandemic recommendation adherence.

Ninety-three percent of participants shared that they were worried (to varying extents) about getting sick with COVID-19 and 91% were worried about their family getting infected. Despite the worry, the majority of the participants (79%) agreed that as an HCT patient it was easy to follow recommended precautions such as social distancing, handwashing, staying away from sick individuals during the pandemic.

In this descriptive, cross-sectional study conducted during the acute phase of the COVID-19 pandemic, HCT patients showed high distress levels secondary to inability to socialize and perform routine physical activity as well as concern about COVID-19 susceptibility.

Respondents also reported that the pandemic had an impact on their stress and anxiety and that they primarily relied on approach-based coping styles. The data suggest that although the pandemic abruptly disrupted the healthcare system in general, most HCT participants were able to receive transplant-related care and caregiver support, with about one-third indicating disruptions to their routine medical care. Most participants also found it easy to follow COVID-19 restrictions and had a general willingness to continue participating in telehealth even following lifting of restrictions.

In patients with cancer, psychological distress results in poor treatment outcomes leading to poor QoL. 28 Physical activity and exercise are known to often serve as feasible and effective interventions for managing stress, anxiety and depression in cancer patients. 29, 30 Results from our study align with this notion since participants reported increased levels of distress and also frequently cited an inability to do physical activities as one of the reasons contributing to their distress. Prior research has identified that early-phase transplant patients demonstrate clinically significant anxiety and depression, with the number of depressed patients increasing two-fold with just two weeks of preventive routine isolation. 31, 32 Though the current study enrolled HCT participants in different phases of the transplant process, it is important to note that the pandemic resulted in increased isolation policies for many individuals -including HCT patientswhich likely contributed to the increased anxiety and depression reported by the respondents.

Patients queried in the current study noted frequent use of approach-based coping strategies. Given that a lower level of symptom related distress is associated with the use of approach-focused coping strategies, 33, 34 it is possible that they were experiencing fewer HCT related symptoms at the time of the survey, though this was not explicitly assessed. Coping can also be dynamic across the disease continuum. In the initial phases, patients with cancer may draw from their existing coping strategies to manage distress and psychological well-being followed by the development of additional strategies to lead a meaningful life as they continue along their cancer trajectory. 35 Some of these respondents may have adapted strategies over time and identified enhanced ways to deal with the transplant process including remaining positive, maintaining normal life routines, finding acceptance, and engaging in religious coping. 36, 37 Some of these strategies were identified in our study and may have resulted in enhanced coping amidst a pandemic compared to the general population.

Most HCT participants in the current study were able to receive care for any transplantrelated condition, indicating that access to transplant care was not a concern for these participants. It is also important to acknowledge that technology has played a vital role in healthcare during the pandemic and positive experiences have been reported by oncologists and patients. 38, 39 In addition to avoiding non-essential admissions to the hospital, telehealth has helped in providing psychological support for patients. 27, 40 Respondents in our study shared their willingness to participate in televisits even after the pandemic, providing transplant providers with novel opportunities to provide intervention for supportive care and consultation services in the future.

Surprisingly, most HCT participants did not have any disruptions in caregiver support. It is possible that caregivers resided in the same household and therefore patients had easy access to their caregiver with no disruption due to the pandemic. Considering that participants were at different phases in their transplant process, caregiver support may have distinctively impacted patients who were undergoing transplant and hospitalized during the pandemic (course of the study) with additional guidelines and visitor restrictions in place, versus a long term HCT survivor.

During the pandemic, there were several recommendations and preventive measures that were in place to ensure public safety and impede the spread of the disease. As expected, most HCT participants in our study (about 80%) stated that it was easy to follow the suggested recommendations and measures as an HCT patient. This is likely secondary to the fact that HCT patients are accustomed to taking infection prevention measures even in the absence of the pandemic due to their immunocompromised status. This is similar to other research concluding that immunocompromised adults and adults with chronic diseases in general were more likely to adhere to recommended COVID-19 preventive behaviors, such as hand washing and maintaining social distance. 41, 42 

The study's findings are limited in several respects. First, this cross-sectional study represents a heterogenous sample of HCT patients at various phases throughout the transplant process who were recruited from a single transplant center, limiting the generalizability of the data. Response to recommendations and patients' perspectives may vary based on the regional policies and regulations that were in place. Second, since the study does not capture prepandemic transplant history or coping strategies and other assessments during respondents' transplant process, we are limited in our ability to infer impact of the pandemic alone. However, this study highlights experiences of this unique HCT population during the peak of the COVID-19 pandemic. Third, recruitment from a single site during the acute phase of the pandemic also resulted in a relatively small sample size.

Despite these limitations, this study provides valuable information regarding perceptions and experiences of HCT patients during the pandemic, suggesting that these data could provide additional insight into coping responses to a wide variety of stressors HCT patients may encounter. We have identified frequently reported factors affecting distress levels and frequently used coping strategies in HCT population. Future studies on identifying types of interventions and resources that HCT patients need to address distress in alignment with coping strategies would be an important next step.

In sum, HCT patients reported experiencing relatively high levels of distress during the initial phase of the COVID-19 pandemic in 2020 but were also likely to use healthy, approach based coping methods to deal with this stress. This dynamic should be further explored with healthcare providers and patients together, both for use in future health emergencies but also to best help immunocompromised patients manage their stress, their mental health, and the current COVID-19 pandemic, of which the consequences are likely to persist with differential effects.

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors Declarations of Interest: None 

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Figure 1: Appraisal of COVID-19 pandemic as a stressor