key: cord-1034105-uffichyq authors: O’Neil, Erika R.; Lin, Huiming; Shamshirsaz, Amir A.; Naoum, Emily E.; Rycus, Peter R.; Alexander, Peta M. A.; Ortoleva, Jamel P.; Li, Meng; Anders, Marc M. title: Pregnant and Peripartum Women with COVID-19 Have High Survival with Extracorporeal Membrane Oxygenation: An Extracorporeal Life Support Organization Registry Analysis date: 2021-11-12 journal: Am. j. respir. crit. care med DOI: 10.1164/rccm.202109-2096le sha: f5685ea3ebb8418f237fb43684e6ab998f1c10a7 doc_id: 1034105 cord_uid: uffichyq nan In the United States, 131,512 pregnant and peripartum women have been affected by coronavirus disease , with 200 associated deaths (0.15%) (1) . The hormonal, physiological, and immunomodulatory changes during pregnancy increase susceptibility to respiratory infections and may predispose women to more severe presentations of COVID-19 (2) . COVID-19 in pregnant or peripartum women is associated with higher risk for preterm birth, preeclampsia, cesarean delivery, and perinatal death and higher rates of ICU admission, mechanical ventilation, and extracorporeal membrane oxygenation (ECMO) when compared with pregnant or peripartum women without COVID-19 or when compared with nonpregnant women with COVID-19 (2) (3) (4) . Venovenous (VV) ECMO is an invasive strategy to support oxygenation and ventilation for respiratory failure when conventional therapies have failed. We investigated the survival and complications of pregnant and/or peripartum women with COVID-19 supported with VV ECMO reported to the Extracorporeal Life Support Organization (ELSO) Registry. This retrospective cohort study included all adult women (>18 yr) supported on VV ECMO with COVID-19 between January 2020 and April 2021 reported to the ELSO Registry, representing 213 international centers in 36 countries. The primary outcome was survival to hospital discharge, and secondary outcomes were ECMO-related complications in the pregnant and/or peripartum cohort. Pregnant state was collected in the ELSO COVID-19 addendum as a comorbidity. Comorbidities and ECMO-related complications were defined according to ELSO data definitions. This study was granted an exemption by the Baylor College of Medicine Institutional Review Board. We compared pregnant and peripartum patients with the nonpregnant female cohort with categorical variables as exact numbers with percentages and continuous variables as median values with interquartile ranges. Categorical data were analyzed with Fisher's exact or Pearson's chi-square and continuous variables with the Wilcoxon-Mann-Whitney test. Overlap propensity score weighting was performed to investigate the effects of pregnancy on outcomes while adjusting for bias due to potential confounders. Propensity scores for patients being pregnant were estimated using a multivariable logistic regression model with a priori identified factors (race, age, pre-ECMO cardiac arrest, admission time to ECMO initiation, driving pressure, mean airway pressure, pH, Pa O 2 /FI O 2 ratio, asthma, chronic heart disease, diabetes, hypertension, overweight/obesity, disseminated intravascular coagulation, neurological disease, chronic kidney disease, acute kidney injury, acute respiratory distress syndrome, heart failure, myocarditis, pneumonia, pneumothorax, septic shock, nonpulmonary infections, pulmonary vasodilators, buffering agents, and renal replacement therapy). Then, overlap propensity score-weighted logistic regression models were used to compare outcomes between pregnant and nonpregnant patients, in which each patient is weighted by the probability of belonging to the opposite status of her pregnancy (5) . Bonferroni correction was used to correct for 10 outcomes in the propensity score analysis, leading to statistical significance if a P value , 0.05/10 = 0.005. There Table 1) . Nonpregnant patients were more likely to have comorbidities. The majority of patients in both groups were proned before ECMO. There were no differences in pre-ECMO status or ECMO duration (Table 1 ). Comparing the pregnant and/or peripartum cohort with the propensity score-adjusted comparator cohort, the pregnant or peripartum group were more likely to survive to hospital discharge (84% vs. 51.5%; overlap propensity score-weighted OR, 1.18; 95% CI, 1.10-1.27) and suffered fewer ECMO-related renal complications (overlap propensity score-weighted OR, 0.90; 95% CI, 0.84-0.97) ( Figure 1 ). There were no other ECMO-related complication differences between cohorts. Pregnant and peripartum women with COVID-19 have increased morbidity, ICU admission, mechanical ventilation, need for ECMO support, and mortality when compared with nonpregnant women with COVID-19 (2-4). The Society for Maternal-Fetal Medicine guidelines for the management of severe COVID-19 acute respiratory distress syndrome endorses the use of ECMO for postpartum patients and pregnant women ,32 weeks' gestation with refractory hypoxemia, to facilitate in utero fetal development (6) . The Society for Maternal-Fetal Medicine recommends that ECMO should not be withheld from pregnant patients who may potentially benefit (6) . Indeed, our study supports the use of VV ECMO in this population, with increased survival for pregnant and peripartum women with severe COVID-19 who received VV ECMO support compared with a propensity-matched cohort of VV ECMO-supported nonpregnant women with COVID-19. We report that pregnant and peripartum women supported on ECMO for COVID-19 were more likely to be Hispanic, Black, or Asian when compared with the nonpregnant cohort. Severe maternal morbidity, or unexpected outcomes of pregnancy that result in short-or long-term health consequences, are more prevalent in non-Hispanic Black women and Hispanic women than in White women in the United States (7) . During the pandemic, Black and Hispanic pregnant women were disproportionately affected by COVID-19 (4, 8) . These racial and ethnic disparities in severe maternal morbidity and mortality are evident in our study. Pregnant and peripartum women were less likely to sustain renal complications than the women of reproductive age supported on ECMO in our study. Angiotensin II, progesterone, and increased nitric oxide, produced during pregnancy, increase renal plasma flow by decreasing vascular resistance, which may explain the lower rates of renal injury (9) . Although previously considered higher-risk ECMO candidates, pregnant and peripartum women did not sustain more ECMO-related complications, consistent with other reports (10) . Importantly, no pregnant or peripartum women sustained limb complications, despite the majority experiencing femoral vein cannulations. Lastly, these pregnant and peripartum women with COVID-19 sustained few bleeding complications and no more than their matched nonpregnant cohort, despite anticoagulation and pregnancyrelated coagulation changes. Our study has limitations. Retrospective, registry-based studies are at risk of selective reporting by centers. Unidentified confounders may be present, despite incorporating a propensity score analysis with overlap weighting by accounting for 28 variables. The pregnancy indicator in the ELSO COVID-19 addendum does not distinguish if actively pregnant or how many weeks postpartum. In addition, the outcomes of the pregnancy and outcomes beyond hospital discharge are not known. The use of VV ECMO to support pregnant and peripartum women with respiratory failure from COVID-19 was associated with To the Editor: Obstructive sleep apnea (OSA) is characterized by complete or partial pharyngeal obstruction during sleep, causing recurrent desaturations and arousals (1). Continuous positive airway pressure (CPAP) applied through the nose splints the airway open and abolishes OSA (2) . Oronasal CPAP violates this principle, because oral pressure neutralizes positive airway splinting pressure transmitted inside the collapsible portion of the airway (pharynx) delivered by nasal pressure (3, 4) . One recent study confirms this hypothesis by showing that the acute change from nasal CPAP to oronasal and oral CPAP during induced sleep resulted in progressive obstruction of the upper airway in patients with OSA (5). In another study, a high percentage of oral breathing was associated with failure of CPAP titration during midazolam-induced sleep (6) . A recent meta-analysis showed that oronasal CPAP is associated with higher residual apnea-hypopnea index (AHI), higher pressure, and lower adherence than nasal CPAP (7) . Despite all this evidence, oronasal masks are widely used, and several patients with OSA are well adapted to oronasal CPAP in clinical practice (6) . We therefore hypothesized that patients with OSA who are well adapted to oronasal CPAP will breathe predominantly through the nose during natural sleep. Patients with OSA from the sleep outpatient clinic of the Heart Institute regularly using CPAP with an oronasal mask were invited to this two-step study. The protocol was approved by the ethics committee (SDC 4149/14/129). All patients who evaluated the acute effects of CPAP route change during midazolam-induced sleep (6) were invited. In the present study, the patients underwent a full-night polysomnography (PSG; Embla) for CPAP titration using an oronasal mask with sealed oral and nasal compartment. The flow and pressure of the compartments were determined by two heated pneumotachograph and a calibrated pressure transducer, captured in a data acquisition system (Spike2), that was synchronized to the PSG system. Breaths obtained during the sleep study were individually analyzed using the nasal and oral pneumotachograph signals (5) . Based on the absence or presence of flow (.10% of the total flow on the nasal or oral compartment), each breath was classified as nasal, oronasal, or oral. When flow in the oral compartment occurred only during inspiration or expiration, that particular breath was classified as oral inspiration or oral expiration, respectively. Each patient was classified as nasal, oronasal, and oral breather based on the breathing pattern of the majority of breaths (.70%) throughout the sleep study. The breathing pattern was also analyzed according to the state (awake vs. sleep), sleep stage, and position. Paired Student's t test and Wilcoxon signed-rank test was used to compare the breathing pattern according to tested covariates. All 13 patients analyzed previously during induced sleep (6) agreed to participate. One patient was excluded owing to technical problems. The patients (n = 12) were on oronasal CPAP for 5 6 4 years and were predominantly males (62%), age 61 6 9 years, with body mass index 29.7 6 3.6 kg/m 2 , and had a baseline apnea-hypopnea index of 44 6 18 events/h. Total sleep duration was 5.7 6 0.7 hours, and sleep efficiency was 76.4% 6 7%. CPAP was successfully titrated in all 12 patients at a median of 10 (range, [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] cm H 2 O. The residual AHI at the best CPAP level was 6 6 4 events/ h. A total of 76,996 breaths were analyzed during sleep (ranging from 4,452 to 7,925 per patient). Eleven patients were classified as nasal breathers (mean nasal breaths, 93.5% 6 7.3%; range, 75.9-99.9%) (Figure 1 ). Optimal CPAP of the nasal breathers was Data on COVID-19 during pregnancy: severity of maternal illness refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fcases-updates%2Fspecial-populations%2Fpregnancy-data-oncovid-19.html#pregnant-population Coronavirus disease 2019 (COVID-19) pandemic and pregnancy Maternal and neonatal morbidity and mortality among pregnant women with and without COVID-19 infection: The INTERCOVID multinational cohort study CDC COVID-19 Response Pregnancy and Infant Linked Outcomes Team. Update: characteristics of women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status -United States Overlap weighting: a propensity score method that mimics attributes of a randomized clinical trial Management considerations for pregnant patients with COVID-19 Racial and ethnic disparities in the incidence of severe maternal morbidity in the United States Coronavirus disease 2019 pregnancy outcomes in a racially and ethnically diverse population Renal physiology of pregnancy Successful treatment of pregnant and postpartum women with severe COVID-19 associated acute respiratory distress syndrome with extracorporeal membrane oxygenation