key: cord-1039745-8i2bpoi1
authors: Pianura, Elisa; Di Stefano, Federica; Cristofaro, Massimo; Petrone, Ada; Fusco, Nicoletta; Albarello, Fabrizio; Lapa, Daniele; Cicalini, Stefania; Campioni, Paolo; Schininà, Vincenzo
title: Coronavirus-HKU1 Pneumonia and Differential Diagnosis with COVID 19
date: 2020-04-23
journal: Radiol Cardiothorac Imaging
DOI: 10.1148/ryct.2020200162
sha: 65c57aece341d444c148a8f83e9df3a78fc77bcd
doc_id: 1039745
cord_uid: 8i2bpoi1

nan

74-year-old female, residing in Rome, was admitted on March 4, 2020 with fever and dry cough for 5 days. She had an epidemiologic link with her sister, who tested positive for SARS-Cov-2. Laboratorial studies revealed elevated C-reactive protein and normal white cell count with neutrophilia. Chest CT obtained at admission showed multiple ground-glass opacities in both upper and left lower lobes, with small pleural effusions (Figure 1a ). The patient was negative for SARS-CoV-2 on three polymerase chain reaction (PCR) nasopharyngeal swab tests. Serological tests for SARS-CoV-2 were also negative. A subsequent analysis for other respiratory viruses was positive for HKU1-CoV, and follow-up CT performed after 2 weeks of therapy showed almost complete radiological resolution (Figure 1b) .

Although chest CT has been used for diagnosing coronavirus disease 2019 (COVID-19) (Figure 2 ), it relies on relatively nonspecific signs, such as multifocal and peripheral ground-glass opacities, consolidations, and crazy paving, which can be also found in other viral pneumonias 1-3 . We illustrate a case of HKU1-CoV pneumonia, a novel group 2 coronavirus discovered in January 2004, which has been also associated with community-acquired pneumonia 4 

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