key: cord-1039745-8i2bpoi1 authors: Pianura, Elisa; Di Stefano, Federica; Cristofaro, Massimo; Petrone, Ada; Fusco, Nicoletta; Albarello, Fabrizio; Lapa, Daniele; Cicalini, Stefania; Campioni, Paolo; SchininĂ , Vincenzo title: Coronavirus-HKU1 Pneumonia and Differential Diagnosis with COVID 19 date: 2020-04-23 journal: Radiol Cardiothorac Imaging DOI: 10.1148/ryct.2020200162 sha: 65c57aece341d444c148a8f83e9df3a78fc77bcd doc_id: 1039745 cord_uid: 8i2bpoi1 nan 74-year-old female, residing in Rome, was admitted on March 4, 2020 with fever and dry cough for 5 days. She had an epidemiologic link with her sister, who tested positive for SARS-Cov-2. Laboratorial studies revealed elevated C-reactive protein and normal white cell count with neutrophilia. Chest CT obtained at admission showed multiple ground-glass opacities in both upper and left lower lobes, with small pleural effusions (Figure 1a ). The patient was negative for SARS-CoV-2 on three polymerase chain reaction (PCR) nasopharyngeal swab tests. Serological tests for SARS-CoV-2 were also negative. A subsequent analysis for other respiratory viruses was positive for HKU1-CoV, and follow-up CT performed after 2 weeks of therapy showed almost complete radiological resolution (Figure 1b) . Although chest CT has been used for diagnosing coronavirus disease 2019 (COVID-19) (Figure 2 ), it relies on relatively nonspecific signs, such as multifocal and peripheral ground-glass opacities, consolidations, and crazy paving, which can be also found in other viral pneumonias 1-3 . We illustrate a case of HKU1-CoV pneumonia, a novel group 2 coronavirus discovered in January 2004, which has been also associated with community-acquired pneumonia 4 A novel coronavirus from patients with pneumonia in China Clinical and High-Resolution CT Features of the COVID-19 Infection: Comparison of the Initial and Follow-up Changes COVID 19 INMI Study Group. 2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation Clinical and Molecular Epidemiological Features of Coronavirus HKU1-Associated Community-Acquired Pneumonia Imaging profile of the COVID-19 infection: radiologic findings and literature review