key: cord-1043708-k92ult42 authors: J, Jeyavenkatesh; P, Saravanapandian; M, Amali JancyMargaret; R, Shanmuga Priya title: Effect of Siddha Medicine Poorna chandirodayam and Gorojanai mathirai among Covid 19 Patients Suffering From Hypoxia – A Case Series date: 2022-02-02 journal: J Ayurveda Integr Med DOI: 10.1016/j.jaim.2022.100553 sha: 8a01050a95eb8bfe5c1bba8906e1ebdd71e815fc doc_id: 1043708 cord_uid: k92ult42 Gold, sulphur and mercurial formulations in Indian alchemy are consumed in conjunction with suitable adjuvant for the better result of their synergistic action, reduced toxicity and consequently boosting their bioavailability via the body's cells due to their nano size resulting in improved effectiveness. Poorna chandrodaya chendooram is a well-known mercurial mixture containing gold and sulphur that has traditionally been used to treat a variety of diseases including tuberculosis, jaundice, fever, rat-bite, malignant ulcer, sprue, and male sterility. Fel bovinum purifactum (Gorochanai) is an expectorant. It is used to treat fever, nausea, dyspnea, general weakness, headache, and other symptoms in children. Gorochanai pill relieves asthma, hiccups, cough, and Hemiplegia. It acts as a bronchodilator. The second wave mutant virus has better transmission potential and a shorter incubation period than the first wave. Some diabetic patients treated for SARS-CoV-2 with high dose corticosteroids had a decrease in angioinvasive maxillofacial fungal infections (Mucormycosis). Without using synthetic steroids and with optimum oxygen support, this case report emphasises the therapeutic success of administering Poorna chandirodayam and Gorojanai mathirai together with herbal and herbomineral Siddha formulations as a supplementary when required in the early inflammatory phase of COVID-19 infection and hypoxic situation. 5 patients with the laboratory-confirmed diagnosis of coronavirus (SARS- CoV2) infection admitted in the approved Siddha Covid hospital have been involved in the study. When the drug is properly prepared and given in a safe dosage during the duration of treatment there will not be any side effects. Metal-based medications Poorna chandirodayam and Gorojanai mathirai been demonstrated through these case series to be safe and useful in COVID19. Poorna chandirodaya chendooram is a well-known mercurial mixture containing gold and sulphur [1] that has traditionally been used to treat a variety of diseases including tuberculosis, jaundice, fever, rat-bite, malignant ulcer, sprue, and male sterility [2] . To aid with titration, hibiscus and aloe juice are added [3] . These pharmaceuticals are mostly composed of a variety of substances, and as a result of their synergistic effect and purifying process, their toxicity is reduced and consequently the bioavailability is enhanced [4] . These medications are efficacious at extremely low concentrations [5] . Although phytochemical analysis of Poorna chandirodaya chendooram revealed the presence of flavonoids, phenols, and Vitamin C, a full picture of its toxicokinetic remains unknown [6, 7] . Fel bovinum purifactum (Gorochanai) is an expectorant. It is used to treat fever, nausea, dyspnea, general weakness, headache, and other symptoms in children. Gorochanai pill relieves asthma, hiccups, cough, and hemiplegia. It acts as a bronchodilator. The pill balances vatha and kapha, as well as enhancing pitha [8] . Some diabetic patients [9] The following A 68-year-old female was admitted with complaints of dyspnea, cough, for 16 days. Intermittent oxygen support (2l-5l) was maintained. Continued the same treatment. The patient feels better. Symptoms reduced. A 57-year-old male patient was admitted with complaints of cough, dyspnea. The After the administration of the intervention on fifth day, it has been reduced as follows D- At the time of discharge patients were advised for home quarantine for the next 7 days. The discharge medicine kit containing the following medicines ( The most notable outcome of this study is a reduction in clinical symptoms and an increase in oxygen saturation. Because this was an observational trial, the medications were The following charts represent the laboratory investigation such as D Dimer, LDH, Ferritin, CRP and PTT levels before and after the intervention for each of these five patients. • Because this is a case study with a small sample size, bigger sample size is required before we can design a standard methodology for the treatment of COVID-19. • The physical distance between the patient and the doctor made direct examination and observation of the patient difficult. • Dealing with the patient's mental health was more difficult than dealing with the infection itself. • The patient's financial situation was the reason they couldn't afford a CT scan and other investigations at the time of discharge and follow up days. • It was difficult for maintenance personnel to keep the atmosphere clean and sanitary because they were concerned about the spread of infection. It has been seen that the patient's condition has not worsened. As a result, it may be assumed that the treatment of COVID-19 with the prescribed Siddha medications halted the disease progression to a more critical stage. Despite having a severe cough and fever of more than 39.1 degrees Celsius, the patient did not deteriorate. The findings were so positive that We state that informed consent was taken from all the patients for this study. Full de-identified data of the analyses are available upon request to the corresponding author. 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