key: cord-1049333-a2bar9nl authors: Campisi, Alessio; Poletti, Venerino; Ciarrocchi, Angelo Paolo; Salvi, Maurizio; Stella, Franco title: Tension pneumomediastinum in patients with COVID-19 date: 2020-08-02 journal: Thorax DOI: 10.1136/thoraxjnl-2020-215012 sha: dc2aac09223c49ab38f1dc095297454f225449a7 doc_id: 1049333 cord_uid: a2bar9nl nan A 65-year-old obese male, with no other comorbidities, was admitted to our intensive care unit for acute respiratory failure due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The patient was mechanically ventilated (intermittent positive pressure ventilation autoflow mode with tidal volume of 6 mL/kg, positive end expiratory pressure (PEEP) 12 cmH 2 O, respiratory rate 20 breaths/min and fractional inspired oxygen (FiO 2 ) to the lowest level to maintain arterial pO 2 in a range of 55-60 mm Hg) for 7 days before his condition abruptly worsened. He became haemodynamically unstable with changes in the cardiac electrical activity and hypotension unresponsive to catecholamines. An initial plain chest X-ray revealed widespread subcutaneous emphysema. Chest-CT demonstrated a massive tension pneumomediastinum. Mediastinal decompression was performed via two incisions, one at the sternal notch and one below the xiphoid process (figure 1). The posterior wall of the sternum was liberated of pericardial fat using blunt dissection with fingers and peanut sponge forceps. A chest tube was placed from the inferior incision and connected to a suction system to avoid any recurrence (figure 2). A laminar drain was inserted from the superior incision into the pretracheal space and connected to a closed system to reduce aerosolisation (Biotrol System 2 bag, B. Braun Medical). After the procedure the ventilation mode was modified, reducing the PEEP to 8 cmH 2 O and respiratory rate to 16 increasing the FiO 2 to 80%. The patient was haemodynamically stable and remained on mechanical ventilation for 6 more days followed by cycles of non-invasive ventilation for a further 5 days at which point the two tubes were removed and the incisions closed with simple interrupted sutures. He was transferred to a respiratory ward where he went on to make a full recovery and was discharged 2 weeks later. Tension pneumomediastinum is a life-threatening condition especially in critically ill patients. One of the most common situations in which it occurs is prolonged invasive and noninvasive ventilation with high end-expiratory pressure. 1 Due to the high number of patients with SARS-CoV-2 related respiratory infections being treated with this type of ventilation, we are seeing an increasing number of tension pneumomediastinum cases. Air leakage from the alveolus occurs due to a pressure gradient between the alveolus and the perivascular sheaths. If the pressure gradient is maintained, the air tracks along the vascular sheaths to the mediastinum. 1 2 Due to increasing mediastinal pressure a compression of the great vessels occurs, leading to decreased venous return, hypotension and finally to cardiac collapse. 3 The initial diagnosis may be difficult due to associated subcutaneous emphysema that covers the underlying disease on chest X-ray. Treatment may be conservative, reducing the airway pressures, allowing permissive hypercapnia and increasing the oxygen percentage of the airflow to denitrogenate the mediastinal space. 1 2 Considering the fragility of patients with COVID-19, this approach is often insufficient, thus surgery may be necessary. In our experience, the approach we COVID-19 with spontaneous pneumomediastinum Tension pneumomediastnum: a rare cause of acute intraoperative circulatory collapse in the setting of unremarkable TEE findings Patient consent for publication Next of kin consent obtained.Provenance and peer review Not commissioned; externally peer reviewed.This article is made freely available for use in accordance with BMJ's website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.