SEVERAL CHOICE HISTORIES Of the medicines MANNER and METHOD Used in the CURE of the PLAGUE.  
WRITTEN By that Famous( and in this DISEASE) Incomparable physician, ISBRANDUS DIEMERBROICK; A Professor of physic.  
And now Translated into English, with his own ANNOTATIONS upon every HISTORY.  
Wherein not onely the choicest Antidotes are set down in his Cures, but also several Things which prove mortal to all that use them.  
London, Printed in the Year 1666.   

FAMOUS HISTORIES of the METHOD IN THE CURING of the PLAGUE.  

The First Famous History.  
THe Maid of Anth●ni Vos, a Wine-Merchant,( 1635. Novem. 6.) fell ill: about Evening I was called to Her: finding Her sick at Heart, and sick of a fever, with great pain in Her Head; Her pulls was quick and weak, and somewhat unequal, but kept her strength: She had two small Pustules about the bigness of Aniseed, red and painful; one ●n the right Dug, and the other in that part of the Breast, where the ribs meet and join together.  
A certain sign of the Plague. I prescribed her a Sudorifical Drink, which put her into a sweat all that night, by which she was much refreshed: which sudorific was thus made.  
The Extract of Cardus Benedictus, and Salt of Wormwood, each one Scruple: of the Salt of Carduus half a Scruple, of Treacle Androm one Dram, of Treacle-water and Cardus Beuedictus water each one ounce: fifteen Drops of oil of Vitriol. Let these be made a Drink.  
The next day the Pustules were as broad as the Nail of your Thumb, and were blackish Carbuncles, having upon the top of them a little Blather, which being crushed, there came out a black venomous Matter; and then the Carbuncle( which before lay hide) now appeared: upon which we laid Unguentum Apostolorum,& Basilicum, and a plaster of Diachulum cum gummis.  
And, to quench her Thirst, We gave her this Juleb; Of Cardus water one pound, of Scabius and Vinegar of each half a pound, syrup of Citrons two ounces, and oil of Vitriol as much as to make it gustful: Let these be made into a Juleb.  
In the afternoon I gave her the Sudorifical Drink again, upon which having sweat well, then that Carbuncle, the which was in the middle of the ribs, where they meet, and then the Poultess which I took care to be prepared, was laid to the Carbuucle, and shifted thrice a day.  
I appointed them to take the quantity of a Hasle-nut three or four times a day, of this Electuary.  
Of Species Liberantis one Dram, Elecampane, of Candid Orangepiele, of diascord Fracastorii.  
Then we gave the Juleb again( and the Boches separated from the adjoining parts) and a Cleansing Ointment, mingled with Unguentum Apostolorum, Anointed three or four times with it, and then with the Unguentum Aureum, which brought it to a Scar, the hallow place being filled with Flesh, She Recovered.  

Annotations.  
ANno Domini 1635, The Summer was very hot, Famous for this, That the two Potent Armies of France and Holland besieged Lovane in Brabant: In this Summer, the Plague, which then was very Malignant and Pestilential, and begun to be bad in Noviomagensis, by the coming of the two Armies: the cure of this Disease, by reason of the Newness of it, was difficult at the first: but not long after we found, in that Plague, that letting of blood was very good for the Sickness. About the end of September this fever was much abated, so that fewer then fell sick of it: but, in most of those who were sick of this Distemper, had read and Purple Spots. At the end of October many were sick without these Spots, and died in two dayes: then letting of Blood was very hurtful: at November it began to be very bad.    

THE SECOND FAMOUS HISTORY.  
PEter Van Vort, who lived at the Sign of the Queens Head, Jan. 24. 1636. was taken ill of the Plague: In the beginning desired my assistance; he Vomited, and was exceeding distempered: his Pulse swift, and unequal, his Head ached, and found a Swelling in one of his Groins: I prescribed a sudorific, which in the Evening he took: Confection of Hiacinth, and Salt of Scordium one Scruple, the Salt of Cardus Benedictus half a Scruple, Theriace Androm, diascord, each two Scruple, Treacle Water, and Cardus Benedictus one ounce, oil of Vitriol twelve Drops, mingled: let them be made up.  
He Sweated much all the night, but not sleeping; for I bid him he should not sleep within eight houres: After all the forementioned symptoms( by this one Sweat) did vanish, and his Swelling in his groin fell, and the Sick Man the next day gathered strength, and then for some dayes every day took once or twice of this Electuary.  
Powder of Bezoar, 1. dram, the Roots of Elecampane, the pills of Oranges each 3. drams, of Treacle 1. dram, diascord 2. drams, syrup of Scordium q. s.  
When as he thought himself cured, but had not gone to stool for some days, I gave him some pestilential pills, half a dram, after which he went to stool twice or thrice; and after that wanted no more Medicines, being fully recovered.  

Annotations.  
IN this acute Disease delays are very dangerous, and I have often observed those, who in the beginning of the disease take Medisines, are soon cured, but being neglected in the beginning, the danger is very great: as Sennestus saith, lib. 4. de Febribus cap. 6. I think many men died because they took Antidotes no sooner, and that many might have been preserved, if taken before the poison had corrupted the humours: and I have observed that those who have taken medicines at first have done well, but if they do not take any thing within 12. hours after they are ill, not one in a hundred escapes.    

THE THIRD FAMOUS HISTORY.  
GErharhd Lucas, one who sold Cherries in the Street Hesia, had the Plague, with a high fever, he had also great pain, and headache, an inward burning, dryness of tongue, thirst, and pain under his arm, without a swelling, he took two Antidotes, by which he sweat very much; but after the second sweeting, in stead of the swelling under his arm, there came a great Carbuncle; from which I presaged his death; the third day he died.  

Annotations.  
CArbuncles, if in the place where Swellings are used to be, it is a presage of Death.    

THE FOURTH FAMOUS HISTORY  
I Ames ʋander, a valiant Captain, perceiving himself infected, having a great pain under his arm, without a swelling, presently upon his own head sent for a chirurgeon; he let him blood under his arm, having taken some ounces of blood, he went whom; forthwith he was taken with a great trembling, he vomited exceedingly, with great pain of heart and decay of strength: then they sent to me, I gave him a sudorific Electuary, which he vomited up: I gave him another Antidote which he kept, but could not sweat: the next day the fever increased much, the sick man was exceeding thirsty but cast up all drinks, he grew faintish until Seven of the Clock at morning, then again coming to himself, he complained much of weakness and pain under his arm, died at noon.  

Annotations.  
FOrestus and Platerus being called to the Plague at delft, presently let blood; and addeth, that all those who were let blood 12. or 24. hours after they were sick they died: We have observed that letting of blood never succeeded well unless it were some rare example, though in the beginning of the distemper, but those who ever, were let blood at any time( we observe) always die.    

THE FIFTH FAMOUS HISTORY  
John Dubbart, being taken with a fever, no outwasd sign of the Plague, so that those of his house did not think that he died of the Plague, but within twelve hours after that he was put in the Coffin, they saw that many black spots appeared in him, certain signs of the Plague.  

Annotations.  
SOmetimes the poison is so deadly, that they die before nature can sand forth any thing, nature being weak sendeth forth neither Carbuncles nor blains, but after they are dead there appeareth black spots in his back: And therefore in the time of a great Palgue, you are not to think it is not the sickness, because no signs of it appear, for many times either nature is come to that weakness, that it cannot expel it.    

THE SIXTH FAMOUS HISTORY.  
A Certain Laundress, by name Belia, who washed clothes in ours and many other houses, she served Gertruda, the Maid of Dimmer de Raet, who was sick of the Plague, and lay down in the Garden; when as I had administered divers medicines unto her, and having cut off the Carbuncle, she was then in good health, at which the Servants of Dimmer de Raet were very glad; yet I saw this woman very sad, and oftentimes fetching very great sighs, and often to weep: I once between her and myself inquired the cause of her mourning, but at the first time I could get nothing out of her, but at length by many fair words extorted from her, that she would tell the cause of her grief to me, upon this account, that I would swear unto her never to tell any thing of it, nor of the event thereof, which accordingly I did.; then she with tears in her eyes said, I knew well enough that this Maid would not die but live, but the wife of Dimmer. de Raet will certainly die, who loveth me very well, and therefore am I so sad. I asked her how she could possibly know that, when as she now liveth so far off? I saw, said she, upon the floor in his house, at the gate of the great forward chamber, her ghost without a head clothed, and holding the key in her hand, as if she would have opened the door; which sight was very frequently seen by me, and very troublesone to me. But whosoever's ghost I saw without a head, then I presaged her death, which within a few moneths after fell out in this manner: I was glad that I had an opportunity to know whether there were any thing certain in the Doctrine of Spirits, of which there was so much talk. Dimmerus de Raet, together with his wife, dwelled at Utrecht, whether they fled long before for fear of the Plague; I writ to him again, not to come home before Winter; what came of it? after some weeks his wife was taken ill of the Plague, although there was no Sickness in the House nor Town, and very shortly after died.  

Annotations.  
SOcrates testifieth of himself, that at a certain time he had a {αβγδ} not seen by him now and then, but was familiar with him all his life, who dehorted him always, exhorted him never. Plato leaning upon this rest, who knew that Socrates was a saithful man, and would not for the saving of his life lie or do any thing that was not good; he taught by his own experience that there were Ghosts, he confirmed the Doctrine by many such like reasons; after this much hath been said by many of it, some are mortal, some are immortal, some onely evil, some that are good, some weak, others powerful, some sensitive, others not, some that they do couple and breed, others that they have their being out of two of the Elements, some that they are mere species separated from the Object, others are thought to be in the air, some are intelligent; and they have delivered many more of the like Dreams, together with whom many learned men and Philosophers have blotted much paper to no purpose, of which thing more may be seen in Cardanus de varietate rerum, lib. 16. cap. 93. You may red also the jejune opinion of Pselli, who is of the same mind with Cardanus, who may be seen further of this thing in him De subtilitate, lib. 18. and in Scaliger de subtilitate, Exercitation. 355. But all seem to be deceived, who would understand the nature of things out of nature by their gatural ingeny; therefore in this case let it suffice in these things, of which we can have no certainty, to believe the Scripture, which as to the form, quantity, substance, actions, &c. which may indeed satisfy us as to these things, wholly writ for our instruction. The sacred Writ tells us, that oftentimes Angels have appeared to holy men, that Prophets have seen Visions, sometimes one, sometimes another, and that all these were done by Divine Power, who is there doth not believe? Is it not therefore wicked, and not so much as decent, for a Christian to inquire of the nature of these Spirits, what their longitude or weight is, how they are impelled to their actions, and made visible, by what means, and which way they descend from the air? That there are certain diabolical delusions, the Scripture doth tell us; thus the Devil appeared to Eve in the form of a Serpent, and in the form of Samuel to King Saul, who  told him his misforune.    

THE SEVENTH FAMOUS history.  
PEtrus De Wildt, who dwelled in Heart-Street, his Wife being taken with the Plague, and had a Swelling in her groin( which Evil notwithstanding she concealed) Her Husband got the Infection of her: Egdmundus, an English Man, and a chirurgeon, was sent for, who gave her the Infusion of Antimony for a Vomit; She Vomited extremely, and had many stools. In the Evening she came to Me: I found them so ill, that they could scarce move or speak: her pulls was so small, that it could scarce be felt; she had great reachings to Vomit, but could not, which much pained her: her stools were watery. I  told her that her Husband would die, yet ventured to give him a warm Cordial draft; viz,  
Treacle, Androm, 2 Scruples,  
Treacle-Water 1 Ounce,  
Cinnamon-Water, half an Ounce.  
Hence his Vomiting ceased: but there was oftentimes faintings; the next night they both died.  

Annotations.  
FOrestus relateth a Story of a Woman, who was taken with a Swelling of the Plague; That, she lying with her Husband, having the Sore on her, he not knowing of it, presently got the Infection of her, so that she was wholly freed from the Plague, and her Swelling went away: For her Husband did wipe her poison( as it were) with a sponge, and seemed to have kept it for himself. I believe this commonly comes by many Women, who, having the French Pox, give it to their Husbands: thus divers take the Infection.    

THE EIGHTH FAMOUS HISTORY.  
CApitaneus Biscot,( April 26.) In the afternoon began to be ill: about Evening he was in great anguish, and was very restless all the night; the next time I saw him he was pretty strong, and complained of nothing but the Pain at his Heart; for, there was neither Heat, headache, nor Vomiting, nor any other evil symptom: and his Pulse, though quick and weak, yet there was no intermitting. He said, His Heart was as it were in a Press: I gave him this Antidote.  
Theriaca, Androm, diascord, Confection de Hiacinthe, Salt of Scordium, of each half a Drachm.  
Treacle-Water 2 Ounces,  
oil of Vitriol 11 Gut.  
He Sweated violently, but without any change of the Disease: He oftentimes took a convenient quantity of this Mixture:  
Conserve of read Roses 1 Ounce and a half,  
Treacle Andromedes, 1 Dram s.  
diascord 2 Drachm.  
Treacle-Water 3 Ounces.  
juice of Citrons, Cinnamon-water, each 1 Ounce.  
Let them be mingled, and then be strained; and add 1 Drachm and s. of diascord.  
About the evening I gave her an Antidote, viz.  
Butter-Bur White Thistle, Penny Royal, each 1 Drachm s.  
The Leaves of Carduus Benedictus, Scordii, Roots of Citron 3 Dra.  
Carduus and Citron each 1 Drachm.  
Comm●n Water q. s. coquantur, according to Art, to 4 Ounces.  
Treacle 2 Scruple  
Extract of Angelico Scruple 1 s. or one and a half.  
Salt of Wormwood 1 Scruple.  
That night she Sweated a little, without any refreshing; the third day of her disease she took what was prescribed the day before; In the Morning she took this following Powder, dissolved in the former Mixture, viz.  
Of the Oriental Bezoar 15 Gr.  
Pulvis Liberantis 1 Scruple.  
Oriental S●ffron 3 Gr.  
In the evening there came forth some Purple Spots, and the next night she died.  
In the whole course of her Sickness there was no feverish symptom, neither drought, Dryness of Tongue, or Heat, nor a Discoloured Water, nor any of the like; but her Heart was much pained, not by reason of the putrefaction of the H●mours, but from the Malignant quality of the Pestilential poison, which seemed to have insinuated into the very substance of her Heart: Thus we have observed in many others, those great and constant pains of the Heart,( beginning with the Sickness) is very ominous, if not abated by the first or second Antidote.   

THE NINTH FAMOUS HISTORY.  
CHristopher De Four,( whose Sign was Amsterdam,) upon the seventh of April, his Maid had a hard pestilential Sweiling, about the bigness of a Hens Egg, under her right arm, yet she was not feverish, neither did perceive any distemper in any other part of her Body but where the Swelling was; she did her business( as she used to do) and that as cheerfully as before, only she could not move her right arm so freely as she did before: She would take no medicines: she put a plaster of Diachulum upon the Swelling, which presently brought it unto a suppuration, so that it broken, and much Matter run out; and thus was she( without any more trouble) healed.  

Annotations.  
SOme do determine, That the Plague is a Pestilential fever, and that a fever is so essential to the Plague, that there never was, nor ever can be a Plague without a Fever: But now, whether the Reciprocation of the Definition would follow, That every fever is a pernicious Plague or no, I much doubt; nay, it is absurd so to think: and, besides Reason, Experience teacheth the contrary, for, often times we have a fever without any Plague, and often the Plague taketh one without this fever; which is most manifest in those, who, being taken sick of the Plague, are dead immediately; although in some the Heart is so strong, that it is able to sand forth the Malignant distemper into a Swelling, or Carbuncle, and that without any Fever at all appearing in them; An Example of which we have in the forecited Story, many Examples of which we have seen during this Plague among us. Thus also Mercurialis telleth us( in his Book De Peste, cap. 6.) of several, who have had Risings in their Groins, yea, in their very Privities, both Men and Women, who have broken them themselves, without any further detriment: See more of the Confirmation of this thing in the 1 Book, Cap. 12. Ann. 2. in myself.    

THE TENTH FAMOUS HISTORY.  
THe Wife of James Bacrsuelt, a strong Woman, about thirty years of Age, who being taken Sick of the Plague, had a Carbuncle in her right side, under her spurious ribs; she had a fever also, which made her very restless and indisposed; she took divers Antidotes and hieroglyphics: Notwithstanding all these, the Disease continued still at its height, until the fourth day, then it run extremely, more then ordinarily they used to do; which, when I knew, I gave her a sudorific, viz.  
read Corol prepared,  
Terra Sigillata, burnt Harts-horn, of each 1 Scruple,  
diascord 1 Drachm,  
Treackle-Water, Vinegar of read Wine, of each 1 ounce, Mingled for a draft.  
Also, I gave order, That she should take some of this Electuary very often in a day, viz.  
Species Diatrium Santalorum, 2 Scruple,  
Troches of sealed Earth, 1 Scruple s. or one and a half.  
Flower of Brimstone 1 Scruple,  
Conserve of Rosemary-Elowers 3 Drachm.  
Conserve of Red-Roses 7 Drachm,  
diascord 2 Drachm, s. or two and a half.  
syrup of pomegranates, q. s. or as much as sufficeth.  
By these two medicines her Running was somewhat lessened, but was not quiter stopped before the fifth day: the Carbuncle, by the laying on of our Poultess, was brought to a Suppuration, and in a short time was quiter healed: and the Patient, within a few dayes after, in as good health as she was before.  

Annotations.  
IN this Sickness, that which was a good sign, was now a Critical one, to wit, the great running of the Sore: For, this we have often observed, that if, in the beginning it should not be stopped with some astringed medicines, no remedies afterwards would do any good, when it hath once got a head; for, then the Patients strength decaying by little and little, suddenly dieth: So that I do not approve of their council, who, in the critical day would have helped forward, by opening medicines, whereas it is opened too much already: but, of this, see more in my Third Book, Cap. 10. Annotat. 1.    

THE ELEVENTH FAMOUS HISTORY.  
A Certain chirurgeon being taken sick of the Plague, and presently removed to a neighbouring Village, called Lent; and there was laid in a small close Chamber, suffering no one of his Companions to come nigh unto him: upon the twelfth of April, in the afternoon I went to visit him, and found him in a high fever, very weak and indisposed; his Tongue was hard, with a Crust over it: I prescribed him this Antidote, viz.  
Treackle Andromedis 2 Scrup.  
diascord Frac storii, Vinegar of Bezoar, each 1 Ounce,  
Mingled for an Electuary.  
He Sweat much, with great ease, and the Swelling in his groin broken, which I  told him would be very suddenly, because of the great pain which he had; the next day he was much better, and the same sudorific being administered, the swelling increased something; then the Patient being foolish( as many chirurgeons are) I not knowing of it, anointed the Sore with an ointment made of M●rcury: upon this ointment his Swelling partend, his fever was as bad as ever, great listlessness and much Vomiting following, and his strength that night much abated, so that the next day he could scarcely move himself, then he confessed to me, That he had annointted himself with the ointment of Mercury, and hoped his Sore could be cured by it, but now he saw his deadly mistake. I gave one medicine more, which, when he had took, he Vomited up; hey presently cured his Spots, with which within three dayes he dyed.  

Annotations.  
REason,( besides the Experience of the former Story) telleth us, that the use of living Quick-Silver is not 〈…〉 for the Curing of a Sore; and Pareus( lib. 21. cap. 〈…〉 leth the use of Mercurial Anointings, e 〈…〉 son of its Coldness, it seems to drive o 〈…〉, as we have largely declared, Lib. 3. Cap. 12. Annot. 16.    

THE TWELFTH FAMOUS HISTORY  
RUdolphus De Swaert, a Knight, of the Company of Wilmoth, a Valiant Man, and somewhat strong, perceived that he was taken with the Plague; who came to me, and asked my Counsel, saying, That he had this Spot with a little Trembling, and, that he was tormented with a great nauseousness and indisposition; and that he felt a great Pain in his Thigh, but perceived no Swelling: I prescribed him this Antidote, and bid him presently go to Bed, and being well covered, to Sweat lustily Viz,  
Treacle, 4 Scruple,  
diascord, Salt of Wormwood, of each Drachm s.  
Treacle Water, the best White-VVine Vinegar, each Ounce 1 s. Made into an Electuary.  
The next day he returned to me well; and said, That for six or seven houres he Sweated mightily, and in that Sweat his Pain went away, his Swelling abated, and he perfectly Cured.  

Annotations.  
IN every Disease, and especially in the Sickness, that Verse is verified, 
Principiis obsta: sero Medicina parata  
Cum malo per longas invaluere modos.   
Englished thus: 
Come at the first: a medicine late prepared  
strengtheners the Disease, whose Cure is marred.   
For, the Disease by long delays getteth ground, and one Antidote, at the beginning of the Disease, doth more good then ten in the third or fourth day, when it hath got a head, and is not so easily, nor so certainly cured.    

THE THIRTEENTH FAMOUS HISTORY.  
MR. Colbury,( a Noble English Man, who willingly accompanied a Troop, being out of our Tents, the Fortification of Schenkius being besieged) upon the fourteenth of April, entering into the City, said, That he smelled a filthy stink, which was very nauseous unto him; at which his Head began to ache: the next day( when he awoke) he was very sick, perceiving a great stretching in the Arteries behind his ears; he,( fearing the Plague) betimes in the Morning took two Pills of Ruffus,( for he always carried some about him) within six houres after he had half a dozen stools, so that the Pain behind his ears abated; yet his Stomach was so bad that he could not eat any Dinner: About the evening he had three or four stools more, which was attended with great anxiety of Heart, and weakness of Body: the night following he had a great Looseness, with much Pain: on the sixteenth of April, in the morning, he asked my counsel: I perceiving that his Excrements was very avaricious and stinking, being Costive himself; he had a great fever: I gave him this sudorific at six of the Clock in the morning, viz.  
Terra Sigillata, Bole armoniac, read Corol prepared, Harts-horn burnt, each 1 Scruple,  
Extract of Rue, 1 Scruple s. or one and a half,  
Salt of Scordium 1 Scruple,  
Treacle Androm, diascord, each 2 Scruple,  
Treacle water 2 Ounces,  
Made into a draft.  
By this medicine he Sweat three or four houres, and his looseness stayed until noon; presently after none stayed, but soon came again: and he often took a portion of this Electuary, viz.  
Troches of Terra Sigillata, Flower of Brimstone, burnt Harts-horn, each 1 Scruple,  
Sanders, 1 Scruple,  
diascord Fracastorium, Conserve of read Roses, Myva Cidoniorum, each 4 Drachm,  
syrup of Pemgranates, as much as sufficeth.  
To help his Thirst, I gave him this Juleb, viz.  
Cardus Benedictus Lib. 1,  
Scabius water, Lib. s.  
Conserve of read Roses, 1 Ounce s. or one and a half,  
Juice of Sloes, 2 Drachm.  
oil of Vitriol, as much as sufficeth.  
Mingled and Strained, given for a Juleb.  
But, the Looseness was no whit stayed by all these. April the seventeenth I gave him a sudorific, thus prepared: viz,  
roots of Tormentile, Ounce s. or an ounce and a half,  
Some Sanders scraped, 1 Drachmas, or one and a half,  
roots of pomegranates, 1 Drachm,  
Green Burnet Saxifrage, half a Pugil,  
Rue, Cardus Benedictus, dried Scordium, each one Pugil,  
Carduus Seed, and plantain, each 1 Drachm,  
Flowers of field Pomgrannates, read Roses, each 1 Drachm,  
According to Art, make a Decoction to 1. Lib.  
Take three Ounces of this Decoction,  
Troches of Terra Sigillata, Scruple s.  
Burnt Harts-Horn, 1 Scruple,  
Treacle, 1 Drachm,  
diascord, Drachm s.  
After this he Sweat much, and the Pain behind his ears he again perceived, but his looseness somewhat abated, which, soon after the Sweat was as great as ever: afterwards pure blood was voided, hence being very weak he died.  

Annotations.  
HIeronimus Mercularis, and John Maynard, by Avicenna Authority,( lib. 1.4. Tract. 4. cap. 4.) Determined, that the Cure of the Plague must be begun with a Purge; and That Opinion is defended by Zachutus Lusitannus, which Counsel I think not fit to be received, which is contrary to Reason and Experience: because, those things which do disturb Natures Motions are pernicious: Experience teaches us, that Purgings are in no wise to be administered; of which we have spoken more lib. 3. cap. 4. Annot. 1, 2, 3. A small quantity of Pills of Ruffus made him so bad, and disturbed him so much, that no way for the vent of the poison could be found.    

THE FOURTEENTH FAMOUS history.  
THe Maid of Mr. Chaek( for some weaks) was very ill, and complained of the weakness of her Heart, at length being taken with great weakness often fainted: at last followed such a violent Vomit, that, sounding away, she lay as if she were a dying: when I was called unto her, and found her Pulse so weak, and so unequal, I gave her a sudorific: viz,  
Burnt Harts-Horn, 1 Scruple,  
Salt of Wormwood, 1 Scruple s. or one and a half,  
Treacle, 1 Drachm,  
Treacle-Water, 1 Ounce s. or one and a half,  
oil of Vitriol, Gut. 9.  
This being taken, she perceived great pain in her Stomach, and after a quarter of an hour she brought up all her medicine, after which she recovered.  

Annotations.  
WE were deceived in this Patient, whom we judged to have the Plague, who by the taking of an Antidote Lumbricis, was healed: the Air could not Infect her but in the Intestines.    

THE FIFTEENTH FAMOUS HISTORY  
I Was called to one who had the Sickness, together with one who was a chirurgeon: We found him to have four Carbunbuncles, and, with very great symptoms, Indisposition, and Restlessness: great lowness of Spirit, with often Faintings, and violent Vomitings, which continued for some houres, a presage of Death: yet we gave an Antidote, which, when he had Vomited, at last dyed. I had a Discourse with the chirurgeon concerning the cause of this Vomiting, and, amongst others I determined, That it was from the poisonous Nature of the Coat of the Belly; and, the upper orifice of the Belly being fixed, he said, That this came from the Carbuncles in the coats of his Heart, and, that he knew it by Experience: For,( that I might know certainly the cause of his Vomiting) he  told me, That he was at the Dissection of a Man, and, in the upper Ventricle found a place somewhat large, about the bigness of the top of ones Thumb, which was black, like unto a Carbuncle, which blackness going through the Tunicles of the belly: and, if I had had a mind, he would have shown me it in another Sick Person: But, we had no mind to provoke a Wasp, we had rather believe it, then see it.  

Annotations.  
IT is very likely that a Carbuncle sometimes may be in the Tunicles of the Belly, no less than in the other Bowels, and it produceth a deadly Vomiting: but yet I do not say that the Pestilential Vomiting hath this for its cause: which followeth hence, because many escape with Vomiting only, which could not be, if this Vomiting proceeded from no other cause than this. Let it be what it will, I know no Physician to have taken notice of these Carbuncles, only of late Johannes Van Helmont Writeth, that he observed this himself in a Body he Dissected: and found the stomach to be covered with a triple Crust, never observed before by any. But, few will believe Rondeletius, who saith, That a Dead Carcase is not infectious.    

THE SIXTEENTH FAMOUS HISTORY.  
E Eward Grien, an English Man, and Melchior Rowert, a German, both Valiant Men, strong and lusty: in May, for prevention and preservation, they were let Blood in the Arm, and we took out a Pint of Blood: soon after they were let blood, they were taken of a sudden with an unusual Trembling and Drowsiness, doubting much whether it were not the Plague or no: but, that they might the better put this imagination out of their mind, one drank two pound of Wormwood-VVine, the other took two ounces of the Spirit of Juniper-Wine: after which they went out together to walk, coming whom about Noon, they could eat no Dinner,( being as could as in the midst of Winter) they went to Bed, and being well covered, slept very soundly for some houres: at length, arter they awoke, they were both very ill, both being much pained, one Vomiting, and the other complained of the swimming of his head, and the great pain in his head: I was desired to see them, perceiving they both had strong fevers, with a small, quick, unequal Pulse, very Thirsty, and as weak as if they had lain sick a long time: They had took of Treacle 1 Drachm, White-VVine Vinegar 2 Ounces, Juniper oil half a Scruple, which Sweated them, but no comfort: one of them had two Carbuncles in his Breast and in his Hand: at evening so weak, that they neither could, nor would take any thing: Drank nothing but Water. On the third day in the afternoon Edward died: the other lived to the fifth day, and died at midnight.  

Annotations.  
THere was a great Error committed by the chirurgeon in this Pestilence, when, for a little Money, commanded letting of blood: they said, It was the best Preservative against the Infection, and thus were they the cause of many a ones Disease, and Death. I scarce ever knew any one let Blood for prevention, but miscarried: and, those who took the Infection, after Blood-letting, were worse than those who took it, and were not let blood before.    

THE SEVENTEENTH FAMOUS HISTORY.  
WHen Natharius Stuaet, a Scrivener, living near to the straight Gate, and next door to the Dancing-Schoole, was sick of the Plague, with a Looseness: I was sent for to see him, as soon as I came into his Chamber, I presently smelled a mighty stink, with which I was much moved: after a short time that I was with him, going out of his House again, forthwith I was very sick, much pained at Heart, so that I questioned not but that I had the Sickness: wherefore,( laying aside all business) I went home, and took six Pipes of Tobacco, by which time all the former symptoms were gone, and I was as well as before: then going abroad( to see my Patients) I took one Drachm of Treacle, and then was presently well.  

Annotations.  
I Had this often, during this Plague: So that, as soon as I had the Infection, I fell to the smoking of Tobacco: but, on a time I visited a Baker and his Wife, who lay ill of a Pestilential Looseness, and I was much altered by that great stink, then, as I used to do, I went to the taking of Tobacco: I was not so soon well, but, having taken a Pipe or two of Tobacco, I was overwhelmed with so much sleep and pain, that( whether I would or no) taking an Antidote went to sleep, and then being wakened to visit some sick Men, who stayed for me, by reason of my giddiness I could scarce raise myself, and Vomited with great pain: at length I arose, leaning upon my servants shoulder, I came to the Fire, then I took Tobacco: when I had taken two or three Pipes, the giddiness of my Head vanished, but troubled a little at heart: then taking heart, fearing nothing, took half a Drachm of Treacle, and a good draft of Burnt Wine, with some Cinnam●n and Nutmeg, and then I went into the Air, and, as I was walking sweat very much, and so I continued till ten of the Clock at night, and then( without any pain at all) returned whom as well as before, and was hungry enough at my Supper, at the close of which I took a Pipe of Tobacco: I hold this as a continual remedy, I took it in the beginning of the Plague, and did me much good, and this hath been observed by many. They relate also, that in Londons Great Plague, no Tobaconist was Infected: but here it was not so, for many of them were infected: For, one English Man, who had many Children and Servants, yet no one had it but a Maid, and she soon recovered.    

THE eighteen FAMOUS HISTORY.  
OTto de Linett, a strong man, had a Carbuncle in his arm, and great pain in one of his thighs, with a drowsness and pain of head: by the chirurgeons advice he took  
Treacle, 1 Drach.  
Vinegar, 1 Ounce.  
Oil of Juniper gut. xii.  
And thus covered warm, sweated a little; after some hours being awakened, he complained of the great pain of his head: I being called to him the second day, then I gave him another Antidote, by which he sweat much, but the pain of his head no whit abated: On the third day he sneezed often without any intermission, which I could not hinder by warm milk put into his nostrils, neither by any other means: having sneezed 100. times, died.  

Annotations.  
WE have observed these mortal sneezings in several other Plagues; although in other Diseases sneezing sheweth a strong Brain, but in the Plague generally mortal: and sheweth that the venom of the Disease is fixed in the Membranes of the Brains, and that they are mortified, when that cannot be cured but by sneezing, no more than a Carbuncle can by vomiting and hiccough. Cardanus observeth also, That Sneezing, in a Plague, hath been Mortal.    

THE NINETEENTH FAMOUS HISTORY.  
MY Cousen Johannes de Goldt, after he had dwelled in an Hospital, being a strong young Man, perceiving a Pestilential Rising in his groin, he concealed it; and when( as he was tormented with a great pain in his head, he took some cephalic Pills, a Drachm of Pillule Cochiae,) he took nine Pills it wrought with him, giving him some ease, but afterwards a very great Looseness: his Swelling struck in, and he was very weak for four and twenty houres, but I could by no means stay his scouring, the third day he died.  

Annotations.  
NOt onely this Example, but many others, tell us, that Purging medicines are Mortal in the Plague; It is strange, that Averroes should commend such medicines as Pillule Cochiae, which Pills, how profitable they are in the Plague, it appears from the former History; but, we never knew that these Pills, or any other Purges, until( after the seventh day of the Disease) they were given, with success.    

THE TWENTIETH FAMOUS HISTORY.  
STephanus, a Scrivener, who lived behind St. Johns Church, he being very angry,( I know not for what) went home, and was took with a Trembling, and presently after with a burning fever, with great Thirst, Restlessness and Pain; and a little while after his Tongue was black, and he had two Carbuncles in his Breast: I gave him divers Antidotes, but he kept very few of them, but Vomited them up again: but, all these profiting very little, and his strength being brought very low, at the end of the second day he died.  

Annotations.  
ANger is( as we have shown before) very pernicious, and very much disposeth our Bodies to the Plague: and those who have fallen sick, upon an Angry Account, most commonly have worse symptoms then others; as violent fevers, headache, &c. which others have not had.    

THE XXI. FAMOUS HISTORY.  
MArgaret de Tienen, who lay down in the Garden of Mr. Haeften, perceiving that she had the Plague, drank her own Urine twice: the second day, by my Counsel, she took a sudorific, after that she had Sweated very much there appeared a Rising behind her right Ear, very big, and soft; which in four and twenty houres came unto that bigness, that it covered the whole side of her neck: the fourth day the Spots appeared, and then she died.  

Annotations.  
THose, who have any hard Swellings in their Neck, among the Muscles, if they increase but flowly, they may be cured, but if their Swellings are White and hard, increasing very much, and that in a very short time, not one in five thousand is ever cured.    

THE XXII. FAMOUS history.  
PEter Byis, a strong young Man,( April the seventh) was taken sick of the Plague, with a gentle fever; he had a swelling under one of his arms, together with great pain of heart: I gave him two or three medicines, but all did no good: the fever( for two or three dayes) increased very much; he became so weak, and so very sick with the medicines, that after the second day I could scarce Administer any more: Upon the tenth of April he was very much pained at Heart, and in the afternoon died.  

Annotations.  
THe Pestilential poison having got such deep root in his Heart, and his inward heat being decayed, was mortal to him; which brought a Putrefaction of the Humors, and a fever, but it was so small, that it was not dangerous at all.    

THE XXIII. FAMOUS HISTORY  
and, the Maid of Wilhslmus, being strong, and very well, in May( as she used to do) she applied three or four Cupping Glasses to her Feet, with Scarification, which took seven or eight ounces of blood from her; afterwards she fell a shivering, and within a few houres she was so drowsy that she fell asleep: when she awakened she found a pain at her Heart; after a while she fell a Vomiting violently: I found her in a fever, her Pulse was weak, quick, and uneven; her Urine was as if she ailed nothing: About noon I gave her this Antidote, viz.  
Treacle, Androm, Discordium, Pracastorii, of each 2 Scruples,  
diascord one Scruple and an half,  
Treacle water one ounce and a half,  
Juice of Citrons half an ounce,  
Mix them.  
After she had taken it she sweat much; and found a pain in her groin, but no Swelling: as for the pain at her heart it abated not: presently after her sweeting she found her self as shiverish as before; therefore I gave her,( within three houres) the same sudorific as before; with which, having sweat the following night, the next morning seemed to be somewhat better, and then she had a hard Swelling appeared in her right groin; That day she would take no medicine at all, and thought that she had wanted my Counsels no more: She did eat a little boiled Milk with Bread, and by the Counsel of her Landlady, laid a cabbage leaf unto the Swelling, anointed with Rape oil; on the third day her fever returned again with as much violence as before,( which was not wholly gone the second day, but somewhat lesser) with a great pain in her head, vehement Thirst, and violent Vomiting: but the Swelling in her groin fell quiter: then she came unto me again, I gave her two hieroglyphics, which she presently brought up again: I prescribed her some Cordial Julebs, and some other things, at length I gave her four spoonfuls of this Mixtures, viz.  
Conserve of read Roses 6 Drachms,  
diascord Fracastorii 2 Drachms,  
Treacle Water. 3 Ounces,  
Juice of lemons, Cimnamon Water of each one ounce.  
Let them be mingled, and stand for one hour, afterwards let them be strained.  
I also prescribed them to lay on a plaster of Treacle of Andromedes, spread upon London Paper; and then being warmed at the Fire, to be laid upon her belly, which presently stayed her violent Vomiting: at night also I gave her this sudorific, viz.  
Salt of Wormwood, and of diascord, of each one Scruple.  
Extract of Angelico half a drachm,  
Treacle Water 2 Ounces,  
oil of Vitriol, 14 Drops.  
Mingle them, and make them into a Portion.  
This made her Sweat gently, and her fever began to be abated, which the next day was as great as before, and continued with violence until evening, at which time that Distemper continued longer than effectually: on the next day the fever abated, but she was very weak; she drank small Ale, in which we put some drops of oil of Vitriol to suppress the terms; I gave this Poultis, and I appointed her to take some of this Electuary often in a day, viz.  
read Cerol prepared, of Burnt Harts-Horn, of Terra Sigillata, of Oriental Bezoar ston, of each half a Scruple.  
diascord Fracastorium one Scruple, with Syrrop of sour pomegranates.  
Make of them a Poultis.  
Species of Diatrium Santalorum 2 Scruples,  
read Corol, Terra Sigillata, Harts-Horn burnt, of each one Scruple,  
diascord Fracastorium 3 Drachms,  
Conserve of read Roses 5 Drachms,  
Juice of Sloes one Drachm and an half,  
syrup of sour pomegranates, as much as needs.  
The sixth day her terms increasing, and she growing weaker, she died in the evening.  

Annotations.  
IN this Plague it was Mortal to take away Blood, even from those who were well; so that the very proposing to any, That they should be let Blood, struck( as it were) an horror into all their Members: for, what time soever( and though the Blood was taken never so cautiously) yea, in the most healthful Bodies, the Pestilence most commonly followed it: because( that the veins being open) there is a greater advantage for any infection to enter, and corrupt the Humors.    

THE XXIV. FAMOUS HISTORY  
A Strong country Man, perceiving a great pain in his Head, with his Heart very much pained also, he asked for a medicine of the chirurgeon, that might Purge him lustily; who gave him a draft of burnt wine, with Antimony, which made him vomit violently, that he voided many peccant Humors; and by it he was so weakened, that they thought he would die presently; wherefore they sent for me, that I should see him: I found the Sick Man wearied greavously with strivings to Vomit; wherefore I commanded those of the House to warm a Pint of White-Wine, and that they should put in some Powder of Cinnamon, and Nutmeg, and that they should give it him warm, and( he being covered warm) to let him sleep; this being done, his Vomiting stayed, and he slept almost all that night.  
The next Day he slept well, and when he awoke he was very well; being withal so very hungry, that he could not be satisfied with two Meales together.  

Annotations.  
THose who had Vomitings very often, seldom escaped: nay, scarce one in a hundred escaped as this Man did, which was, because he was very strong, and of a healthful Constitution.    

THE XXV. FAMOUS HISTORY.  
ANntonius Knuit a Leather-seller, dwelling in the Market, who was somewhat strong( May 29.) about evening began to be ill; and, feeling a pain under his arm, sent for me: his Pulse was uneven and swift; and, considering it was at the beginning of the Disease, his strength was but little, and his heat but little more than used to be; his Urine also was as at other times, he was somewhat appressed, and drowsy, inclining to Vomit, but did not: I gave him this Antidote, viz.  
Two Scruples of Treacle,  
Half a Drachm of diascord,  
Salt of Wormwood, the Eyes of Crabs Prepared, of each one Scruple,  
Treacle water an ounce and an half,  
Juice of Citrons one ounce,  
Mix them all.  
After he had taken this he Sweat exceedingly, and found ease, and an hard great Swelling arose under his arm; I laid on twice a day this Poultiss, viz.  
roots of White lilies 2 ounces,  
Green roots of Elecompane one ounce,  
Mallones, Marchmallowes, camomile Flowers, of each one Pugil,  
And nine Figs, as much fair water as sufficeth, boil them according to Art, and let them be baked; adding Leaven, of Lint-Seed, meal, of each one ounce,  
Doves Dung one ounce and an half,  
Honey, and Hogs-greece, of each six Dracbms.  
Make all into a Poultis.  
May 31.( In the Morning) he drank of this Apozem, viz.  
roots of Angelico, Butterbur, of each six Drachms,  
Tormentil roots, of the Pills of dried Citrons, of each half an ounce,  
Of the roots of Ostrutii the quantity of 2 Drachms,  
Scabius, Dandelion, balm, Scordium, of each one Pugil,  
Cardus Benedictus one Pugil and an half,  
Green Rue half a Pugil,  
Cardus Benedictus Seeds, and of the greater could Seeds, of each one Drachm and an hafe,  
read Fitches one ounce and an half,  
As much Fair Water as sufficeth, boil them to two pounds, strain them, and put to them Syrrop of Scordium, and of juice of Citrons each one ounce.  
In the Evening he took this, viz.  
Treacle, Androm. diascord Fracastorium, Salt of Wormwood, of each half a Drachm,  
Treacle Water, Vinegar, of Bezoar, of each one ounce.  
He took it, and Sweat, and was much refreshed.  
June 1. He nauceated all things, and was ready to Vomit: to prevent it, I gave him this, to Drink two or three spoonfuls a day, viz.  
Conserve of read Roses 6 Drachms.  
Taeacle of Androm 2 Scruples  
diascord 1 Drachm and an half  
Treacle water 3 ounces  
Roses half an ounce  
Cinnamon 6 Drachms  
Juice of Citrons one ounce,  
Mix them.  
Let them stand two houres, and then strain them, and add  
Confection of Hyacinth 2 Scruples  
Of Alkermis 2 Scruples  
Mingle them,  
He drank twice of this Apozem.  
In the evening I gave him this Bolus, dissolved in the former mixture,  
Take Mithridate Dimoc. one Scruple and an half  
diascord one Scruple  
Salt of Wormwood, Confection of Hyacinth, of each half a Scruple  
oil of Vitriol 4 Drops,  
Mix it, and make it into a Bolus.  
About the evening he( of himself) Sweat very well: his Swelling under his Arm increased, and by this Critical Sweat his Disease was overcome, his oppression at heart, headache, and other symptoms ceased, and afterward his Swelling under his Arm went away by little and little without breaking: all this while he went not to stool, therefore on the seventh of June I gave him a Scruple of the Anti-pestilential Pill, which gave him two or three stools, and so( by the blessing of God) he fully recoveerd.  

Annotations.  
AT this time the Cure was( though seldom) now perfected Critically: and except on the Critical day, all Spontaneous Sweats were dangerous. The tumours of this Patient was dissipated by little and little: and so we have observed, that after the fever was gone, the Swelling went away, without danger to the Patient. Palmarius also observed the same De felre Pestilentiali, Cap. 20. Where he saith, I have seen many fully Cured, without having their Sores broke, the venom by little and little being overcome by Antidotes, the matter of the Swelling being dispersed: but this holds not, when the Swelling goes away before the Disease be overcome, for then it is very dangerous. We would not give the Patient any thing to Purge him before the Disease was Cured: For, we never found, that the Patients being bound prejudiced him, but Evacuations that way( though by Glisters) proved dangerous.    

THE XXVI. FAMOUS HISTORY.  
THe Wife of Gerrhard de Stolck, the third day after she was brought a Bed of a sound child, she had the Plague, and had two Carbuncles on her Breast; but she had no great pain, or fever, nor such bad symptoms as others, all which were hopeful signs. The Infant took the Plague and died, before she knew she had the Plague: the Infant being dead, they sought out some little Puppies to draw her Breasts, for they were full of Milk; they got four, of which two died within two dayes after, and the other died on the fifth day. All that while she took several Antidotes, but all failed, and she died the fixth day, and her Husband and another child foilowed her.  

Annotations.  
MOst Women have the Plague in Childbed, because of the great Alterations, they are then subject to die: and so the Infant, except presently put to Nurse, which appears( not onely here) by this Infant, but by the Puppies.    

THE XXVII. FAMOUS HISTORY.  
THe Wife of a Noble Scotch Man( Douglass by Name) on the 16 of May had the Plague, she was very weak from the beginning of it, and greatly oppressed, and some headache; her Water was thick, her Pulse was weak, quick, and uneven, but not very hot, nor did any signs outwardly appear: I gave her this Antidote, which made her Sweat very well, viz.  
Theriaca Andromach. diascord, Fracastorium, of each half a Drachm.  
Salt of Wormwood one Scruple.  
The Eyes of Crabs prepared one scruple and an half.  
Treacle Water one ounce.  
The juice of lemons, Vinegar of Calendula, of each one ounce.  
She took a Spoonful or two of this mixture after her Sweat;  
Conserve of Roses half an ounce  
diascord Fracastorium 2 drachms  
The Water of Cardus Benedictus, and of Treacle water each two Ounces.  
The juice of green lemons one ounce  
Cinnamon water one ounce and an half.  
Mix them all together, and let them stand half an hour, then strain them, and add, viz,  
The Confection of Hiacinth, without Musk, one drachm.  
May 17. The Disease standing at a stay, she took this same sudorific about noon. I appointed this Apozem, of which she drank three or four times a day, viz.  
The roots of White Thistle, of Butterbur, Dittany, Elecompane, Angelico, of each 1 ounce 2 drachms.  
Of Pelitory of Spain, of dry peels of Oranges half an ounce  
Scordian, Cardus Benedictus, each 1 Pugil and an half  
Sorrel 1 handful, Succory, Burnet, Saxifrage, Baum, Rue, of each half a handful.  
The four great could Seeds, of each 1 drachm.  
read Fitches 1 ounce.  
boil them in Running water to 2 Pound.  
Add to it( when it is strained) of the syrup of Citrons, and of Scordian, each one ounce: make an Apozem.  
May 18. She took the mixture, and a sudorific, to which we added one Scruple and an half of the Extract of Cardus Benedictus: Sometimes she took a little of this Electuary, viz.  
Pulvis Liberantis 1 drachm.  
diascord Fracastorii 2 drachm.  
Of Orange peels Candied, Conserve of read Roses, of each 3 drachms.  
Treacle 1 drachm.  
Confection of Hiacinth without Musk 4 Scruples.  
syrup of the Vinegar of Citrons as much as to make it up.  
That day she drank twice of the Apozem, so that the next night she was very weak, so that she could scarce take any thing; yet she took a little of this bolus, and found some ease, viz.  
Treacle, Confection of Hiacinth, Ori●ntal Bezoar ston, of each one Scruple.  
Make it into a Bolus, lay it up in leaf Gold.  
Hitherto no external signs of the Plague appeared, and the fever( which was not very violent) without any intermission continued.  
May the 20. As soon as she could take any thing I gave her the Apozem again, which she took, and made an end of.  
The next day the same Apozem was made again.  
May 24. Which was the ninth day, there was a Cricis( by a vehement Sweat) not caused by any sudorific, it was a good Cricis: after which her whole Body broken out with little read Pimples, as big as Millet Seed, and itched very much: and also there was a Swelling in her groin, as big as a pigeons Egg, and so she was freed from her anguish, and other symptoms. But, least she should fall into a Relapse, I prescribed the last Apozem on the eighteen of May. I laid also a Poultis to that Swelling, and afterward a plaster, and it went away without breaking, and so by the mercy of God she was fully Cured.  
Three dayes after she fell ill she could eat nothing, and after she used a spare diet, some Broth, with Sorrel, Oranges, Citrons, borage, and such like boiled in it: her Drink was small Ale, for she could not endure Julebs: for the seven first dayes she went but once to stool, nor would I cause her to have one before the Cricis was over: After the Cricis was over I gave her a Scruple of Pillulae Ruffi, which gave her two or three stools.  

Annotations.  
THis Sick Person was very observant of my Directions, and a true Patient, which few are; for she would do nothing without my Advice. When she was not refreshed with the first Sweat, I caused her to be kept in a moderate heat and sweat to the fourth day, hoping that Nature would( by Swellings or boils) thrust out the poison: but, she was very weak that day, and there was no change followed: and when I saw no Crisis upon that day, I fully expected one upon the seventh day; therefore I wished her to be of good cheer, and to continue in that breathing Sweat until the seventh day, and, that she would find the Disease would change: she was very observant of my Directions, although she was in much anguish, and she patiently endured her Sweat until the seventh day, notwithstanding the noysomeness of it, for she shifted not herself all that while: for, I  told her that it was very dangerous to shift her self, but, that no damage would accrue by enduring the noysomeness of the smell of the Sweat: And, although on the seventh day she found no alteration, yet she willingly continued in that Sweat till the ninth day, though the seventh day she was worse than before.  
If any fever had been in this time, she might know then that she had taken the Infection, though there should no sign appear: for many times( though at the first) nothing of the Plague appears, yet it turns to it in a few houres. Though this seldom happens, as both Montanus and Forestus say, There are abundance of continued fevers, some Tertian, &c. which quickly turn to the Plague: Therefore I judge it very good to Administer physic, as if it were the Plague; and not to stay until strength failes, and the Disease grows desperate: For, if you neglect at first, the venom will be so rooted in the Heart, that medicines will do no good: for we must not stay from Oppugning this Enemy until he comes out of his lurking places, and openly appears: nor leave off until you have utterly subdued him, as we in this Cure did.  
But it seldom comes to pass in others as in this Patient, that no symptoms should appear of the Plague before the Critical day: for, although neither Carbuncles, Swellings, nor any Tokens do appear, we are not presently to conclude( as the Common People do) That they have not the Plague: for it may lie hide a long while before it appears to be the Plague: and many times the Malignity of the poison kills, before it appears, as it is generally known: for in divers, the first time such outward symptoms appear, is after they are dead: and many times strength is so weak, that it cannot expel the venom to the outward Parts.  
FINIS.     

February the 1. 1666.  
Printed for Matthew Keinton, at the Sign of the Fountain in St. Pauls Church-Yard.