Lymphatic Voyage: Communicating 4D Immune Cell Dynamics and Lymph Node Architecture Using WebGL-based Animation and Interactivity

Li Yao1 MA, Lydia Gregg1 MA, CMI, FAMI, Ronald N. Germain2 MD, PhD, Mark J. Soloski3 PhD

1Johns Hopkins University, Department of Art as Applied to Medicine; 2National Institutes of Health, National Institute of Allergy and Infectious Diseases; 3Johns Hopkins University, School of Medicine, Division of Rheumatology


 

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Abstract

Lymph nodes are secondary lymphoid organs, where T-cells and B-cells (lymphocytes) meet antigens to initiate adaptive immune responses. The anatomical and molecular cues direct the cell and fluid movements to ensure that the antigens can meet the right immune cells effectively1, 2. Advanced 3D imaging techinques1 allowed the scientists to visualize the lymph nodes. However, teaching lymph node architecture and immune cell dynamics at the cellular level is challenging, due to the lack of visual teaching tools. Lymphatic Voyage is a widely accessible interactive 3D app designed as an educational tool to help instructors and graduate students.

 



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This Vesalius Trust research poster was presented at the 2017
Association of Medical Illustrators' Annual Meeting in Austin, Texas


References

1. Qi, H., Kastenmüller, W., & Germain, R. N. (2014). Spatiotemporal basis of innate and adaptive immunity in secondary lymphoid tissue. Annual Review of Cell and Developmental Biology, 30, 141–67.

2. Woodruff, M. C., Zawieja, D. C., Carroll, M. C., & Jr, J. E. M. (2015). Modeling Lymph Flow and Fluid Exchange with Blood Vessels in Lymph Nodes, Lymphatic Research and Biology. December 2015, 13(4), 234–248.

3. Chung, K., & Deisseroth, K. (2013). CLARITY for mapping the nervous system. Nature Methods, 10(6), 508–13.


Licensing

The authors have chosen to license this content under a Creative Commons Attribution, NonCommercial, NoDerivatives License 4.0 International License.