Erin Choi BSA, Asher George BS, MPH, Silvia Jakubski MA, Mhd Hasan Almekdash MA, MS, PhD, Pranav Sharma MD
Objective: The aim of this study is to analyze the association between the 11-item Modified Frailty Index (mFI) and 90-day post-operative complications in prostate cancer patients undergoing Robot-Assisted Radical Prostatectomy (RARP).
Methods: The Modified Frailty Index was calculated in 216 men who underwent RARP at a single institution. Mean ranks and proportions were compared with the Kruskal-Wallis test, Chi-square test of independence, and Fisher’s exact test. Multivariate logistic regression was performed to determine predictors of 90-day post-operative complications after RARP.
Results: Patients with higher pre-operative mFI (≥2) were more likely to be older in age (P = 0.047), have worse ECOG performance status (P = 0.019), and worse ASA scores (P < 0.01). Intra-operative variables and pathological characteristics were similar between mFI groups. Multivariate logistic regression showed that mFI ≥2 was a predictor of overall 90-day complications after surgery (OR = 3.32, CI = 1.16–9.54, P = 0.026). Multivariate logistic regression also showed that mFI >2 was a predictor of high-grade 90-day complications after surgery (OR = 2.69, CI = 1.24-5.85, P = 0.012).
Conclusion: Prostate cancer patients with higher pre-operative mFI scores were more likely to have a 90-day complication after RARP. The Modified Frailty Index should be assessed pre-operatively in prostate cancer patients to determine the risk of post-operative morbidity and the best treatment plan.
Keywords: Frailty, robot-assisted radical prostatectomy, prostate cancer, Clavien-Dindo
Article citation: Choi E, George A, Jakubski S, Almekdash MH, Sharma P. Frailty is an independent predictor of 90-day complications following robot-assisted radical prostatectomy The Southwest Respiratory and Critical Care Chronicles 2022;10(44):15–21
From: School of Medicine (ES, AG); Clinical Research Institute (SJ, MHA); Department of Urology (PS), Texas Tech University Health Sciences Center, Lubbock, Texas
Submitted: 6/14/2022
Accepted: 6/29/2022
Conflicts of interest: none
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