Gifr of Fk. STANENSF LIBRARY _NEW YORK STATE VETERINARY COLLEGE ITHACA, N. Y. Cornell University Library SF 961.S81t 1893 iT A TREATISE ON THE DISEASES OF THE OX: ‘BEING A _ MANUAL OF BOVINE PATHOLOGY. ESPECIALLY ADAPTED FOR THE USE OF VETERINARY PRACTITIONERS AND STUDENTS. BY JOHN HENRY STEEL, M.R.C.V.S., A.V.D., PROFESSOR OF VETERINARY SCIENCE AND SUPERINTENDENT, BOMBAY VETERINARY COLLEGE ; LATE DEMONSTRATOR OF AND LECTURER ON ANATOMY AT THE ROYAL VETERINARY COLLEGE OF LONDON ; CORRESPONDING MEMBER OF THE ITALIAN VETERINARY ACADEMY ; AUTHOR OF ‘OUTLINES OF EQUINE ANATOMY,’ AND ‘ DISEASES OF THE ELEPHANT.’ FOURTH EDITION. j LONDON: LONGMANS, GREEN, AND CO,, AND NEW YORK: 15 EAST 16th STREET. 1898. All rights reserved. be hd « ge Rt 45 ne x WORKS BY J. H. STEEL, F.R.C.V.S. A TREATISE ON THE DISEASES OF THE DOG; being a Manual of Canine Pathology. Especially adapted for the Use of Veterinary Prac- titioners and Students. With 88 Illustrations. 8vo, 10s. 6d. A TREATISE ON THE DISEASES OF THE OX; being a Manual of Bovine Pathology specially adapted for the Use of Veterinary Prac- tioners and Students. With 2 Plates and 117 Woodeuts. 8vo, 15s. A TREATISE ON DISHASES OF THE SHEEP; being a Manual of Ovine Pathology for the Use of Veterinary Practitioners and Students. With Coloured Plate and 99 Woodcuts. 8vo, 12s. Lonpon: LONGMANS, GREEN, & CO. ra) ol) Bit a a) lp 9) On PRINCIPAL JAMES BEART SIMONDS, PROFESSOR OF CATTLE PATHOLOGY AT THE ROYAL VETERINARY COLLEGE, HONORARY MEMBER OF THE AGRICULTURAL SOOIETY OF ENGLAND, ETO. WHO FOR SO MANY YEARS PASSED HAS ENCOURAGED THE STUDY OF CATTLE PATHOLOGY, AT ONCE BY PRECEPT AND EXAMPLE, AND HAS THEREBY MATERIALLY ASSISTED IN GIVING TO BOVINE PATHOLOGY IN GREAT BRITAIN SUCH SCIENTIFIC TENDENCIES AS IT MANIFESTS IN THE PRESENT DAY, THIS WORK IS DEDICATED BY HIS FORMER PUPIL, THE AUTHOR. 1881. POSTSCRIPT. Tuts edition of “ Diseases of the Ox” has been edited many miles away from Great Britain. The publishers have endeavoured to avoid material increase in size of the book, although much new matter has been added, there- fore the expedient of small type has, here and there, been resorted to. So it must be remembered by the reader, that smallness of type represents printer’s convenience and expediency, and not unimportance of matter. My best thanks are due to Veterinary Surgeon Fred Smith, of the Army Veterinary School, Aldershot, for his kindness in assisting to correct the proofs. The few illustrations fresh to this edition are from Klein’s valuable little work on micro-organisms, and permission to make use of them is here acknowledged, with thanks. J. HS. Bompay, 1887, PREFACE TO THE SECOND EDITION. Tue five years which have elapsed since first this work was introduced to the professional public have been marked by important increase in our knowledge of the diseases of cattle. Foremost among facts of practical interest and scientific value to be recorded was the discovery of acti- nomyces, which has cleared up several points which we were, for lack of sufficient evidence, in our first edition compelled to consider doubtful. The determination of the distinct pathological nature of “ black leg,” the general acceptance of Pasteur’s anthrax vaccination, the marked progress of Willem’s inoculation for pleuro-pneumonia, introduction of intratracheal injection as a method of treatment for husk, and general application of the theory of micro-organisms in blood diseases will be observed as important matters inserted in this edition as the outcome of recent progress. The author has availed himself of the opportunity afforded by a demand for a new edition to correct such few inaccuracies as escaped notice in the former issue, Vi PREFACE TO THE SECOND EDITION. and also to add a few points which it is considered will increase the practical value of the work to the reader. The additions have been made with as little alteration in style and in bulk as possible. J. H.S. Bompay, 1886, PREFACE. Bovine pathology has not been hitherto adequately re- presented in British Veterinary Literature, but the time has now come when it ought to take up its proper position as a distinct section of veterinary science. Under these circumstances it is somewhat surprising that none of our leading veterinary surgeons have produced a scientific work of a comprehensive nature on diseases of cattle. Tt seems that some, owing to their professional engage- ments, have had little time left for literature, while others have been deterred by supposing that there must already be many preparing to fulfil so urgent a task. An oppor- tunity of preparing a work on this subject having pre- sented itself, I have not hesitated to avail myself of it; and in doing so I have not advanced to my work heedless of the amount of labour involved in it, or of the uncer- tainty of the data on which it would have to be based. My ideal of a work on special pathology necessitated, in the first place, the somewhat dogmatic summary of the general study of disease comprised in the Introduction, Section 1. With the data thus afforded I was in a better position to specially consider diseases of the ox. No trouble has been spared in assigning to each part of the work its proper position, with a view to practical conveni- ence and facility in study. The table of contents is, to a certain extent, an expression of the careful arrangement which I haveadopted. The intimate matter requires some comment; my aim has been to tersely indicate the bear- ings of the subjects dealt with, to point out that which has been based on science and confirmed by experience in contrast with crude theory and superstitious empi- ricism. In following out this plan I have been compelled vili PREFAOE. to omit the arguments which have been advanced in support of many theories. It may be fancied that in these cases I am dogmatic, but a full statement of each controversy would have trespassed too much on my space and perchance on the patience of my readers, to many of whom the work will, even in its present form, seem quite large enough. I the less regret that I have not been in a position to exhaustively treat my subject, since simultaneously with the announcement of this manual appears that of alarger and more pretentious work on the same subject, by an author whose ability has been already proved by an excellent volume on ‘Canine Pathology,’ Professor J. W. Hitt, F.R.C.V.S. My treatise on ‘ Bovine Pathology’ is specially prepared for the veterinary practi- tioner and student. I desire that for the former it may be a useful means of recalling facts, which in the rush of daily business are apt to slip the memory, and may also, afford a ready reference to past periodical literature, through which he would neither have time nor inclination to wade. At the expense of severe literary research I have summarised and arranged the facts which have been communicated to the profession through the medium of our journals. But while I have thus endeavoured to produce an exact statement of the present condition of cattle practice, I have not aimed at a record of pro- found investigation. Neither the state of the profession nor of science demands this, so I have been content to think at every point “how does this concern the prac- titioner ?” The requirements of the student are similar, also his knowledge must be comprehensive and exact for the emergencies of examinations. Thus, I have specially aimed at method, the application of general principles, and precise statement of facts and conclusions. Also I have inserted accounts of methods of administration and other details which might to the practitioner seem trivial. I have endeavoured to as much as possible indicate the relations of diseases of the ox to those of other animals, and have, wherever necessary, alluded to liability of com- munication of disorders to man, as by contagion, meat, PREFACE ix milk, &c. The time has not yet arrived when in considera- tion of special pathology we can afford to omit a hasty sum- mary of the leading points of the anatomy and physiology of the object of our investigations. My method has been chosen in the hope that it will refresh but not burden the memory of the reader. Having thus, to the best of my ability, prepared this work for the veterinary profession, it will be observed that I have made free use of technical terms (all of which, I believe, are explained in the intro- duction), and have not encouraged empiricism by the insertion of numerous prescriptions; I have indicated the line of treatment, but the exact means to be used must be adapted to the emergencies of each case. The few formule given are such as from their general usefulness or repute ought to be remembered by the reader. It will be constantly found in practice that the difficulties arising from complications of disease or from surroundings necessitate special modifications of the methods here suggested. Much of the success of a practitioner depends on his skill in applying general principles to special cases, and acting accordingly. JI may by some be considered to have too much curtailed the list of symptoms of special disorders ; in this matter I have in each case acted advisedly, wishing to economise the labours of the reader. Thus, “ general signs of febrile disorder ” frequently does duty for the somewhat prolonged list of these in detail, and so on in similar cases. There being much difference of opinion among our leading authorities on cattle pathology, it has seemed to me best to express my own opinions, while stating and acknowledging those of others. Thus, I am fully prepared to find that many of my views do not meet with general acceptance. I await the verdict of the professional public, however, since I have proceeded throughout on scientific methods, and have supplemented such practical experience as was at my disposal by most careful literary research. I have endeavoured to express my acknowledgment of the assistance which I have derived from the few comprehensive works on bovine x PREFACE. pathology, and the numerous works on veterinary surgery and medicine which allude to diseases of cattle, as well as from some very excellent writings on special sections of my subject. Accordingly a bibliographical list of these has been inserted, which will, I hope, prove a useful guide to any reader who may wish to work up a special subject. Lastly, I have to acknow- ledge the kind courtesy by which the publishers and authors of the following works have afforded to Messrs. Longmans & Co. the numerous engravings, which have been inserted in the hope of rendering the work of greater value :— Armatage, ‘ Clater’s Cattle Doctor’ (Messrs. F. Warne & Co). Harley & Brown, ‘ Practical Histology’ (Longmans & Co.). : Fleming, ‘ Veterinary Obstetrics’ (Balliére, Tindall & Cox). Colin, ‘ Traité de Physiologie Comparée’ (Balliére & Co.). Cobbold, ‘Internal Parasites of our Domesticated ‘Animals’ (The Field Office). Dobson, ‘On the Diseases of the Ox’ (Messrs. Long- mans & Co.). Hrichsen, ‘ Surgery ’ (Messrs. Longmans & Co.). Cut 4 has been copied by permission from Gant’s * Science and Practice of Surgery.’ Messrs. Arnold and Son, the well-known veterinary instrument makers, of West Smithfield, have supplied me with some cuts of instruments, for which I hereby convey my thanks. Thus I submit my manual to the veterinary profession, and in appearing for the second time as an author, I venture to hope for such favour and consideration as my first effort has received. JOHN HENRY STEEL, NOVEMBER, 1880, CONTENTS. CHAPTER I.—INTRODUCTION. Stcrron 1. General Consideration of Disease.—Etiology, 2; Diagnosis, 3; Symptoms and signs, 4; History,5; Pulse,6; Respirations, 8; Asphyxia, 9; Cough, 10; Internal temperature, 10; Other symptoms and the means of observing them—Prognosis, 14; Death, 15; Morbid anatomy or intimate pathology, 17; Degenerations, 18; Infiltrations, 20; Inflam- mation, 23; Suppuration, 26; Caries and ulceration, 29; Gangrene, 32 ; Necrosis, 33; Varieties of inflammation, 34; Congestion, 35; Hemor- rhage, 36; Solutions of continuity, 37; Functional disease, 37; Post- mortem examination, 38 ; Varieties of disease, 40; Treatment, 41; Opera- tions, 43 ; Nursing and prevention, 46 ; Salutary inflammation, 47; Value of rest, 48; Antiphlogistics, 49; Counter-irritants, 51; Treatment of congestion, hemorrhage, and dropsy, 53. Sgorion 2. The Ox in his relations to the General Consideration of Disease. —Summary of general peculiarities of conformation and internal strac- ture, 54; The influence of domestication on the constitution of the ox, 57; Other predisposing causes, breeding “ in-and-in,” gregariousness, 58; Diet, 59; Pregnancy, 59; Influence of surrounding air and climate, 60; Age, sex, and conformation, 61; Exciting causes, 61; Symptoms, general, 62; Pulse,62; Temperature, 64; Respirations, 64; Cough, 65; Other symptoms, objective, and subjective, 65; Prognosis, 68 ; Treat- ment, 69; Methods of restraint, 70; Chloroform and chloroforming, 74; Nursing and prevention, 75. Sxotion 3. Bovine Therapeutics and Materia Medica.—Methods of admin- istration of agents to the ox, 76; drenches, 76; balls, 77; enemas, 78; inhalations, 79; subcutaneous injection, 80; Doses, 80; Materia medica, tables, 82 to 87; Agents which are administered internally and those which are applied externally, 88; Application of boiling water and blistering, 88; Fomentations and poultices, 88; Disinfection, 89; Bloodletting, 89; The use of setons, &c., 92. CHAPTER II.—DISEASES OF THE BLOOD. Srot1on 1. Non-specific Hamal Affections.—Hasty summary of the anatomy and physiology of the blood in general, that of the ox in particular, 93. Nutritive Disorders : Hypertrophy (plethora), 95 ; Atrophy (anzemia), 96 ; xi > CONTENTS. Cachexia aquaso verminosa (liver-fluke disease), 97; Perverted nu- trition (pyrexia or fever), 99; Necremia, effects of lightning on animals, 102. Variations in Constitution: Increase or decrease of normal con- stituents, 103; Leucamia or leucocythemia, 104; Retention of matter which should be excreted, 105; Carbonic anhydride poisoning, 105; Icterus, jaundice, 105 ; Urwmia, 108; Rheumatism, 109; Hemoalbumi- nuria, muir ill, red-water or black-water, 111; Scarlatina, 115; Purpura hemorrhagica (doubtfully urticaria tuberosa), diabetes insipidus and mellitus, 115; Introduction into the blood of matters soreh to it— ordinary toxic agents, specific toxic agents. Srorion 2. Specific Hamal Affections—On the nature of these disorders in general— inoculation, infection, and contagion, 117; Cancer, 124; Scrofula or tuberculosis, 126; Phthisis pulmonalis, 126; Tabes mesen- terica, 128; Tubercular meningitis, 129; Scrofulous arthritis, 129; Scro- fulous tumours, “ wens” and “ clyers,” 129; Scrofulous inflammation of the supra-pharyngeal lymphatic glands, 180; Tubercular mammitis, 132 ; The essential nature of tubercle, 130; The changes which the miliary — tubercle undergoes, 183; Relations of tuberculosis of cattle to that of man, 134; Bacillus of tubercle, 185; Diagnosis of tuberculous and typhoid ulcers, 186; Actinomycosis, osteosarcoma, spina ventosa or fibro-plastic degeneration of bone, 189; Wens or “ clyers,” cancer of the tongue, 140 ; Milk sickness, “trembles,’”? 141; Pleuro-pneumonia epizootica v. con- tagiosa v. exudativa, 141; Post-mortem appearances, intimate pathology after Dr. Yeo, 146; Treatment, the question of inoculation, 150; Eczema epizootica v. contagiosa, 153; Its complications, 155; Its relations to disease in man, 159 ; Rinderpest, cattle plague, or puschima, 160; Spread of the contagium, 163; Means of eradication, 164; Its pathological equivalent in man (different views), 168; Exanthemata, their general characters, 168; Vaccinia, cow-pox, variola vaccinia, 169; Jenner’s conclusions, smallpox in the cow, 170; Considerations on lymph for vaccination use, 170; Relations to variola ovina, 171; Varicella and vaccinoides, 171; Stages of vaccinia, 172; Infectious aphtha, 173; Stomatitis pustulosa equi, 173; Aphthous disease of the genital organs of cattle, 173; Anthracoid affections, charbon, 174; Its relations with Bacillus anthracis, 175-177 ; Post-mortem appearances of these diseases in general, also curative and prophylactic means, 177; splenic fever, splenic apoplexy, essential charbon, 181; Texas fever, splenic fever (American), or Spanish fever, 182; gloss anthrax, maligant sore-throat, blain or “hawks,” 183; Charbonous gangrene of the lungs, 184; Emphysema infectuosum, known also as black leg, black quarter, &c., 185; Ite rela- tions to true anthrax, Arloing’s methods of inoculation, 185 ; Pyzmia and septicemia, 188; Parturient septicemia, 189; septic mammitis, 190; Glanders, farcy, and strangles, doubtful cases in the ox, 191; erysipelas, 191; and Diphtheria, 192; Croup, the relations of diphtheria of man to “garget ”’ in cows, 193; Gangrenous stomatitis, 193; General considera- tions of non-contagious specific disorders, 196 ; Malignant catarrh, coryza, CONTENTS. xiii or “ glanders,” 197 ; Rabies, “ hydrophobia,” 199; Recurrent fevers, 200; Parasites in the blood or which are distributed throughout the system by the blood, 201; Echinococcus disease, 201. ADDENDUM 1. Poisons, 203.—Classification, 204; Cumulation, 204; Causes of poisoning, 205 ; Examination ofa field, from grazing in which animals are supposed to have been poisoned, 205; Treatment and post-mortem ap- pearances, 206; Special stimulants—strychnia, 208; and ergot of rye, 208; Narcotics—opium, 209; Phosphorus poisoning, 209 ; Chloroform, tobacco, 210; Hyoscyamus and belladonna, 211; Sedative poisons— hydrocyanic acid, aconitum, 211 ; Conium, 211; Colchicum, yew, digitalis, 212; Lead, laburnum, 213; Irritant poisons, astringent poisons, corrosive poisons, 214; Corrosive sublimate, 215; Eliminative poisons—arsenic, antimony, calomel, nitre, 215; Copper-smoke disease, 216. ADDENDUM 2.—Parasites and Parasitismus, 216 ; Animal parasitic organisms, 219 ; Tabular list of parasites infesting the ox and his allies, 222; Vege- table parasitic organisms, 224. CHAPTER III—DISEASES OF THE CIRCULATORY SYSTEM. Srction 1. Of the Heart.—Summary of special points of anatomy and phy- siology of this organ, 225 ; “ Functional” disease—palpitation, 227 ; Or- ganic diseases—inflammation, carditis, or myocarditis, 228 ; Hypertrophy, 228; atrophy with fatty and cretaceous degeneration, also the condition known as “ pouched heart,” endocarditis, 229; Pericarditis, 231; Trau- matic and idiopathic, 234; Hydrops pericardii, rupture of the pericar- dium, cardiac polypi or hematomata, 235 ; Tumours and parasites on and in the heart, rupture of the heart, 236; Malformations and misplace- ments (ectopie), 237. SEcTion 2. Of the Arterial System.—Degenerations (atheromatous and tu- bercular), aneurism, 238 ; Thrombus, wounds of arteries, 239 ; Irregulari- ties, 239. Sgotion 3. Of the Capillary System.—Capillary hemorrhage, 240. Sxcrion 4. Of the Venous System.—Phlebitis, 240; Thrombus, rupture varicosity, 241; Varicocele and tumours of the veins, 242. AppEenpuM 1. Diseases of the Lymphatic System.—Inflammation, mistakenly called “farcy,” 242; Lymphadenoma or lymphoma, 243, AppENDUM 2. Diseases of the Vascular or Ductless Glands.—Spleen— hypertrophy, atrophy, inflammation, parasitic invasion, rupture, 243; Of thyroid and thymus, 244. CHAPTER IV.—DISEASES OF THE DIGESTIVE SYSTEM. Sxcrron 1. Of the Alimentary Canal.—Irregularities and diseases of the lips, teeth, 245 ; and palate, 247; Dropping the cud, 248; Anatomy and phy- " siology of the salivary glands of the ox, 248; Ptyalism, inflammation, parotiditis, 249; Non-occurrence of salivary calculi; the tongue, 250; xiv CONTENTS, _glossitis, 251 ; Induration, 252; Cramp, 253 ; Cystic diseases and injuries, 253; Paralysis, and ulcers, 253; Aphtha, 254; Congenital malformation of the palate, 255; Pharyngeal polypus: the esophagus, 255; Csopha- gitis, fibrous degeneration, dilatation, stricture, 256 ; Parasites, Rupture, 257; Warty growths or degeneration of the mucous membrane, Choking, 258; Passing the probang, 261; Csophagotomy, 263; Vomition, true and false (after Youatt), 264; Anatomy of the gastric apparatus, 265; Rumination, 269 ; Tympany, “ Hoven” or “ Blown,” 272 ; Puncture of the rumen, 276; Impaction of the rumen, 278; Alvitis, 278; Rumino- tomy or “ paunching,” 279; Rupture of the rumen, 280; Foreign bodies in the rumen and reticulum, 281; Parasites, calculi, hair-balls or ega- _ gropiles, 281; Hernia of the rumen and reticulum, Impaction of the omasum, 282; Omasitis, 284; Abomasitis, 285; Impaction of the abo- masum, also atrophy of the lamin of the omasum, 285; Rupture of the abomasum, parasites in it, also rupture of the blood-vessels of the stomach, 286 ; Indigestion, stricture of the pylorus, 286 ; Gastro-enteritis of calves, vulgarly known as “ white scour” or “skit,” 287; The intestines, 288; General anatomical and physiological considerations: colic, simple spasm of the bowels, 291; Colic, flatulent, 292; Impaction or distension with obstruction of the bowels, calculi, intussusception or invagination, 292 ; Volvulus, ileus, or twist of the bowel, 293; Laparotomy, 293; Hernia, 294; Umbilical, exomphalos, 295; Ventral, 297; Phrenic, mesenteric, inguinal and scrotal, 298; Pelvic hernia, “gut-tie” or “bound,” 299 ; Prolapsus ani, 301; Constipation, 302 ; Use of cathartics in cattle prac- _ tice, 303; Hemorrhoids or piles, diarrhea, 304; Dysentery, “ bloody flux,’’ 806 ; Pantas, moor-ill, or wood evil, 8308; Enteritis, 309; Crupous form with fibrinous intestinal casts, 310 ; Intestinal apoplexy, perforation or rupture of the intestines ; of the rectum, 311; Intestinal parasites and tumours, malformations of the intestines, proctatresia or impervious anus, mechanical distension of the rectum, 312. SxEctTIon 2. Of the Liver.—Hepatitis, 313 ; Congestion of the liver, hepati-~ rhoea, hemorrhage from and rupture of the liver, 315 ; Ramollissement or softening, 316; Hepatic hernia, 317. : ADDENDUM 1.—The gall-bladder and its diseases, 317. ADDENDUM 2. The pancreas and its diseases, 318. Sxorion 3. Of the peritonewm.—Peritonitis, 318 ; Ascites or dropsy, 319. CHAPTER V.—DISEASES OF THE RESPIRATORY APPARATUS. Comparison of this apparatus of the ox with that of the horse, also anatomical and physiological details, 321; Auscultation, 322; Nasal and laryngeal sounds, 323; Cavernous rale, sibilus, rhonchus, &c., 323; Examination of the chest of the ox by auscultation, 324; Percussion, 326; Mani- pulation, succussion, and mensuration, 327; Nasal chamber, anatomical facts, 8327 ; Catarrh, 828; Epistaxis, nasal polypus, 329; Parasites, nasal gleet, laryngitis, 330; Tracheotomy, 331; Laryngotomy, 332; Pharyn- CONTENTS. XV gotomy, 333 ; Tumours of the larynx and fractures of the cartilages, 333; The trachea, its anatomy, 333; Bronchitis, 335; Chronic form, 336; Asthma, 337 ; Parasitical form, “ husk,” “ hoose,” “ hoast,” phthisis pulmonalis verminalis, 337; Fumigation, 340; Pulmonary congestion, acute, 341 ; subacute, 341; Pulmonary apoplexy, 341 ; Hamoptysis, 341 ; Pneumonitis, 342, Crupous and catarrhal forms, 342, Interstitial form, 343; Cysts in and wounds of the lungs, 345; “Tic,” 346; The Pleura, pleuritis, pleurisy, hydrothorax, 346; Empyema, 347; Paracentesis thoracis v. thoracentesis, 348 ; Pneumothorax, pleuro-pneumonia spora- dica, 349; The diaphragm, rupture of, 350. CHAPTER VI—DISEASES OF THE URINE AND URINARY APPARATUS. Auatomical features of urinary apparatus, 351; Composition and characters of the healthy urine of the ox, 352. SEoTION 1. Abnormalities of the Urine.—Diabetes simplex v. insipidus, 352 ; Non-secretion of urine, hematuria, 353; Albuminuria, 354. SEctTIon 2. Diseases of the Kidney.—Nephritis, 355 ; Abscess, Renal calculus, 357; Parasites, renal encephaloid, 357. SECTION 38. Diseases of the Urinary Passages.—Calculi in and dilatation of the ureter, 357; The bladder, retention of urine and ischury; passing the catheter, 358; Incontinence or diuresis, 359; Dysuria, strangury, cystitis, 360; Spasm of the neck of the bladder, rupture, inversion (prolapsus), 361; pervious urachus, calculus, and sabulous matter or “ gravel,” 362 ; Rupture of the urethra, lithecstasy, lithotrity, 363; Lithotomy, 364; Tumours in the bladder, 364; urethral calculi, stricture of urethra, pra- putial calculus, 365. CHAPTER VII.—DISEASES OF THE ORGANS OF SPECIAL SENSE. SEorion 1. Abnormalities of the Skin.—Hidebound,” “staring coat,” Classification of skin disorders, 366. Sub-section 1, Non-parasitic Diseases : Inflammation.— Dermatitis, erythema, E. mamillarum (“sore teats”), 367; Eczema, psoriasis, herpes, 368 ; Impetigo (pustular dermatitis), urticaria (nettle-rash or surfeit), urt. tuberosa, stinge (blain or singe), 369; Ecthyma or acne, furunculus, car- buncle, pemphigus, 370. Hypertrophie.—Keratoid, pityriasis, nzvus, 371; Dermopilous cysts, scleroderma (elephantiasis), warts (“angle berries,” verruce), 372. Atrophic—Alopecia (depilation or baldness), 373. Functional—Cdema or anasarca, emphysema, 373; bloody sweat, Pruritus (neurosis), 374; effects of colour on diseases of the skin, 374, Sub-section 2. Parasitic Disorders of the Skin.—Animal Parasitic Diseases of the Skin of Cattle—Mange, acariasis, 375; Phthiriasis (lousiness), estriasis (“ warbles”), 378; tsetze fly, maggots, and ticks, 379. Vege- table Parasitic Diseases of the Skin of Cattle—Tinem, “ringworm,” T. xvi CONTENTS. favosa, (honeycomb ringworm), 379; T. tonsurans, decalvens v. depilens, 380. : SECTION 2. Diseases of the Foot.—Anatomical considerations, 381; Foul (loo, low), 382; Amputation of the foot, 384; Laminitis (founder), loss of a hoof, sore feet, shoeing, 885; Overgrowth of horn, pricks and other penetrating wounds, monstrous conditions, interdigital fibromata, ulcera- tion of the heel, 386. SECTION 3. Diseases of the Ear—General considerations, otitis, 387. SxcTIon 4. Diseases of the Eye and its Appendages, 387. Sub-section 1. Abnormalities of the Ocular Appendages.—General considera- tions, 387; Bony tumours on and fractures of the margin of the orbit, fungus hematodes, lacerations, emphysema, edema, warty growths of the eyelids, 388; Ptosis, tumours on caruncula lachrymalis, 389. Sub-section 2. Diseases of the Hyeball—Anatomical features, conjunctivitis (simple ophthalmia), keratitis or corneitis, 389; opacity of the cornea, nebula, albugo, staphyloma, 390; Congenital hairy tumours, worm in the eye, lymphy deposits in aqueous chambers, specific or periodic ophthalmia (retinitis), 391; Cataract, amaurosis, 392. SECTION 5. Diseases of the Organ of Taste.—Perversion of gustation, 393. CHAPTER VIII.—DISEASES OF THE NERVOUS SYSTEM. General considerations, 394. Srcrion 1. The Cerebro-spinal System.—The brain, phrenitis (encephalitis, cerebritis, phrensy), 894; Epilepsy (megrims and staggers), 396; Apo- plexy, 397 ; Dropsy (hydrocephalus). Hydr. congenitalis, operation for delivery, 398; Parasites, 400; Bony tumours in cranium (“ossified brain”), “stomach staggers,” coma, narcosis, delirium 401; The spinal cord, myelitis; tetanus, 402; Paralysis (palsy), 404; Progressive lipoma- tous paralysis, 406; Adynamia nervosa generalis, 407; Chorea (string- halt), parturient apoplexy (milk fever, dropping after calving), 408; “ Bedsores,” 409; Parturient fever, mania puerperalis, the nerves: neurotomy, division of the pneumogastric nerve, 414. SECTION 2.—TZhe Sympathetic System, 414, CHAPTER IX.—DISEASES OF THE SKELETON, &o. General anatomical considerations, 415. Suction 1. Abnormalities of the Osseous System.—Ostitis, 416; Periostitis and inflammation of the outer lamina of a bone, periostosis and exostosis, 417; Osteophytes, fragilitas ossium, cachexia ossifraga malacia, 418 3 Osteoporosis, rachitis (rickets), 419; Fractures, 420; Of the horns, of the metatarsal or metacarpal bones; of the os innominatum, 421 3 of the ribs, and cranium, “ greenstick fracture”? and separation of epi- physes, 422, CONTENTS. xvil Srorion 2. Injuries to and Diseases of Ligaments and Muscles.—Sprain, complete rupture, sprain of the fetlock-joint, 423; Of ligamentum teres of the hip, ruptured suspensory ligament, ruptured serratus magnus, 424; Displacement of abductor femoris, parasites in muscles, open tendi- nous sheaths, 425. Suction 3. Abnormalities of the Joints.—Arthritis, 425; Hydrops articu- lorum (dropsy of joints), 426; Synovitis, relaxation of the pelvic sym- physis; Dislocations or luxations, 427; Of the patella, 428. CHAPTER X.—WOUNDS AND OTHER SURGICAL CONDITIONS. SECTION 1. Wounds.—Incised, punctured, lacerated, 430 ; Contused, poisoned, gunshot, methods of repair, 431; Treatment, 432; Sutures, 434; Anti- septic surgery or “ Listerism,” 435; Results of wounds, 436. Srction 2. Tumours, 436. Sub-section 1, Malignant.—Cancers, carcinomata, scirrhus, 437; colloid, medullary sarcoma (encephaloid), 4388; Epithelioma, melanosis (“black cancer ”’), treatment, 439; Sarcomata, 440. Sub-section 2. Non-malignant, Innocent, Simple.—Solid, epidermic, or epithe- lial, fibromata, 440; Lipomata, enchondromata, exostosis and osseous tumours, calcareous, lymphomata, cystic, hamatomata, serous abscesses, 441; Bursal enlargements, hydatids, dermopilous cysts, 442; Treatment and surgical removal, 443. CHAPTER XI.—THE GENERATIVE ORGANS. Sgorion 1. Diseases of the Male Organs of Generation.—Anatomical con- siderations, castration, 446; The various methods of procedure, orchitis, 450; sarcocele, varicocele, sterility, hydrocele, injuries and cancer of the penis, 451; Phymosis, urethral calculus, 452; Gonorrhea, “ bull-burnt,” 453 ; Urethritis, 455. SrctTion 2. Diseases of the Female Generative Organs.—Anatomical con- siderations, 455 ; Dropsy and atrophy of the ovaries, 456; Ovariotomy, “spaying,” 457; Menstruation, “cestrum,” or “ heat,” 458; Profuseness, suspension, or retention of cestral products, amenorrhea, sterility, “ free martins,” 459; Utero-gestation, false labour-pains, 460; Signs of preg- nancy, abortion, “slinking,” 461; Premature birth, prolonged utero- gestation, excess in number of the progeny, superfcetation, extra-uterine conception, 463; Cesarean operation, parturition, 464; “Cleansing,” or “after-birth,” retention of the foetal membranes, 465; After-pains, placenta previa, hemorrhage per vulvam, 466; “ Blood flux,” presenta- tion, normal; mechanical assistance sometimes required, 467; False or abnormal, 468-475; Diseases and irregularities of the calf—hydroce- phalus, ascites, emphysema, polysarca, oedema, 475; Monstrosities, 476; “Lusus nature,” 478 ; Embryotomy, 478; Twins, 480; Diseases of the b XVIii CONTENTS. foetal membranes, dropsy of the amnion, hydramnios, 480; Hair-balls in liquor amnii, obstructions of the genital passages, tumours, imper- forate vagina, 481; Stricture of os uteri, soft strictures, vaginal hysterotomy, impervious os uteri, 482; Persistent hymen, torsion of the uterine neck, 483; Dilatation of os uteri, imperfect post-partum contraction of the uterus, uterine inertia, 484; Furor uterinus, bydrops uteri, inflammation of the uterus, endometritis, 485; Ecthymatous disease of the arms of veterinary obstetrists, metroperitonitis or puerperal peritonitis, 486; Lacerations of the uterine walls, uterine fistula, rupture of the uterus, 486; Prolapsus vel inversio uteri, 489; Amputation of the uterus, inversion of the vagina, 493; Inversion of the bladder, hernia uteri or hysterocele, tumours in the uterus, malformations of the uterus, 494; Rupture of the vagina or vulva, recto-vaginal fistula, vesico-vaginal fistula, leucorrheea (“ the whites ”), vaginitis, 495. ADDENDUM 1. The Lactiferous Apparatus.—Absence or imperforated state of the teats, 496; Mammitis, v. “ garget,” downfall of the udder, 497; Scirrhous state of the mammary gland, 498; Congestion, tumours on the teats, 500; Obstructions in the teats (as lacteal calculi), inflammation of the lining membrane of the duct, stricture, relaxation, lactorrhea, 501. ADDENDUM 2. Milk and its Diseases, 501; Agalactia, 502; Hypergalactia, changes in the quality, 503. ADDENDUM 8. Diseases of very Young Animals, 503.—Umbilical hemor- rhage, perviousness of the urachus, gastro-enteritis, accumulations of meconium, inflammation of the umbilical cord v. omphalitis, edema of the umbilicus, 504. Bibliography, 505. FIG. 165. 20. 23a. 24, 25. 26. 27. 28. 29. 31. 382. 33. 34. 35. 36. 37, 38, LIST OF ILLUSTRATIONS. Exploring trocar (Arnold) ‘ . Fatty degeneration of the heart (Harley andl Brown) is Pus-corpuscles and mucus-corpuscles (Harley and Brown) Process of healing of a wound by granulation (after Gant) Spray diffuser for anesthetics or disinfectants . : The “bull dogs” applied (Armatage) . . ‘ An ox prepared for casting (Armatage) . . . The stomach-pump in use (Armatage) . . . Application of steam to the nostrils (Armatage) . Method of covering the nostrils for steaming (Armalagey Hypodermic syringe (Armatage) . . ‘ Clyster syringe (Arnold) . : . . . Ox prepared for bleeding (emaiase) A : . Bleeding fleam (Arnold) . ; 2 : . Seton needles (Arnold) . . . 7 . Red blood-globules (Dobson) s 3 5 . Fascicola hepatica (Cobbold) . 7 % . Distoma lanceolatum (Cobbold) . . . . Amphistoma conicum (Cobbold) . ; . Elemeuts of an encephaloid tumour (Harley and poe . Tubercle (Harley and Brown). ‘ Incipient pleuro-pneumonia epizootica (Simonds) Advanced stage of pleuro-pneumonia (Simonds) . . Bacillus anthracis (Klein) . . Gloss anthrax, or blain, early stage (Armatage) 248, 24c. Bacilli (Klein) . ; 3 Malignant catarrh, second stage (asmiatase) ‘ : Teonia echinococcus (Cobbold) . . ° Infusoria from alimentary canal (Colin) . 7 Cysticercus tenuicollis (Cobbold) : 7 * Beef measles in the heart of a calf (Cobbold) * ‘ A beef measle (Cobbold) . . . . ‘ Pentastoma (Cobbold) 7 fs é Thoracic contents, as seen from the left aida (BSimondé) . The heart with right cavities opened (Simonds) . ‘ Ectopia cordis (Fleming) . 7 : ‘ . Artery ligature knots (Erichsen) . é j ‘ Tying an artery (Erichsen) : A piece of a thymus of a calf (Harley and Brewed . Incigors of the ox (Chauveau) . ‘ : : 223 223 223 228 225 226 237 240 240 244 246 39. 42, LIST OF ILLUSTRATIONS. Teeth of the ox (Chauveau) . . . . Salivary glands with their ducts (Simonds) . . Passing the probang (Simonds) 7 r . . Armatage’s wooden gag. . Forceps or grasping probang (dsmasapey. a Csophageal groove (Carpenter) Rumen and reticulum opened, seen from the left (Simonds) Ditto, muscular coat (Simonds) . Omasum and abomasum (Simonds) . 7 Gastric mass, from the left (Simonds) . < ‘ ‘ Ditto, from the right (Simonds) . : - s . Rumen in state of distension (Simonds) . ‘ . Seat of puncture of rumen (Simonds) . . ‘ . Trocar and canula 3 . . : . . Stomachs of the calf (Simonds). . ‘ . . Position of intestines of the ox (Colin) . , . ‘ Intestines, from the left (Simonds) x * ‘ % Ditto, from the right (Simonds) . ‘ : j < Truss for the umbilical hernia (Armatage) . . . Clamps for umbilical hernia (Armatage) . . . Liver and pancreas of ox (Simonds) i Tracheotomy tube (Armatage) . Z Animal wearing tracheotomy tube (hematawe) . Larynx and os hyoides of the ox (Simonds) Bronchi and lungs of ox (Simonds) . : Thoracentesis v. paracentesis thoracis (enistana) Z Ditto, primary incision (Armatage) . ‘ . Kidney of the ox (Chauveau) ; 7 . : Passing the catheter in the ox (armatage) : . Mange insects (Dobson) . i Hair with trichophyton spores (Nantes anid ewe) . Method of applying dressings between hoofs (Armatage) Staphyloma (Armatage) . . . 7 Congenital hydrocephalus (Simonds) . . . : Ccenurus cerebralis (Cobbold) 2 . . . Ditto, in sitd (Cobbold) . ¢ é ‘ Natural position of rest, as in adynamia (Ar snuteeds 3 Puerperal (parturient) apoplexy (Fleming) 7 i ‘ The catheter ‘e ‘ i ; ‘ 3 Skeleton of the ox (Dobson) : s : : Dislocation of the patella (Armatage) ‘ Means of prevention of its recurrence (Armatage) Pin or figure-of-eight suture (Dobson) é Interrupted suture (Dobson) 3 Scirrhous growth from the mammary siand (Harley a Browa) Suction trocar (from Erichsen’s ‘Surgery ’) . Pneumatic aspirator . : . ‘ . Miles écraseur 8 . ¥ - + % PAGE 248 261 261 262 265 266 267 268 270 270 273 276 276 287. 289 289 290 296 296 313 331 331 332 334 348 351 359 375 380 384 390 399 400 400 407 413 416 428 428 434, 434 437 441 442 444 LIST OF ILLUSTRATIONS, FIG. 87. Beach’s écraseur . . . . . 88. External generative organs of a bull (Chauveau) . 89. Urethral canal of the ox (Armatage) 90. Castrating clamps . . . . . 91, Female generative organs (Simonds) 92. Maternal and fotal cotyledons of the cow (Fleming) 93. Normal presentation (Simonds) . . . 94 —99. Abnormal presentations (Simonds) 100. Congenital ascites (Simonds) : . 101. Hydrocephalus congenitalis—calf eming) . 102. Harelip (Fleming) . 103. Common embryotomy knife 104, Gowan’s knife . : . . . 105. Finger hook é 7 106. Chain saw . xxi PAGE 449 458 468 469-47 4 - A476 477 479 479 479 479 107. Portion of chorion with plaventulie (from Fleming’ 8 ‘Obstetrics 489 108. Cotyledon of a cow’s uterus (do.) . 109. Gowing’s truss (Simonds) . 110. The loop of Delwart’s truss (Fleming’ 8 ‘Obstetrics 0) 111. Lobules of lacteal gland (after Langer) . 112. Means of supporting the udder in mammitis (Armutape) 113. Injection of fluids into the mammary gland (Armatage) . 114. Section of a cow's teat (Colin) . ‘ 115. Lobule of a mamma filled with milk (Calin . 116. Milk or teat syphon «i ‘ . 117. Parturition forceps e ‘ . . Plate I.—Section of a pleuro-pneumonic lung—Frontispiece. Plate I1.—Feetus in utero—To face page 455. Instruments of control (Peuch and Toussaint)—To face page 72. Page 72, 14th line from bottom should be Vigan. 3 18th ‘5 o 5b Goiffon. 490 » 492 493 + 496 - 499 + 499 + 602 + 603 - 504 LIST OF SURGICAL OPERATIONS AND DIAGNOSTIC MEANS. PAGE 1. Taking the pulse—sphygmograph . : : : ‘ 6 2. Taking the temperature—thermometer 3 ‘ . - (10 8. Ophthalmoscope and exploring needle . : . . (4 4. Method of conducting a post-mortem examination . . - 388 5. Methods of restraint . ; ‘ ‘ $ - 70 6. Use of anesthetics . 3 . a é «74 7. Administering a draught . - a ‘ ‘ - 76 8. Administering anenema . . ‘ . - 7 9. Administering an inhalation . . . 5 : . 79 10. Subcutaneous injection : : . : ; . 80 11. Application of boiling water . : . ‘ ‘ 88, 310 12. Bleeding P . . . . . . . 89 13. Setoning . . . . . . . 92 14. Tests of urine in jaundice . F ‘i . : - 106 15. Inoculation for pleuro-pneumonia . . . . . 161 16. Vaccination . : ; 5 . : . . 170 17. Operation for traumatic pericarditis . c 7 - + 234 18. Ligature of arteries . . ° 7 240 19. Passing the probang . . . i. . 261 20. Esophagotomy . . . : : 263 21. Puncture of the ramen : . . ‘ : . 276 22. Ruminotomy, “ paunching” . : . . ‘ . 279 23. Laparotomy or gastrotomy . . - 293 24, Operation for umbilical hernia rs : ‘ 296 25. Operation for ventral hernia . : 7 - 3 - 297 26. Taxis . , . . A . : A » 299 27. Operation for inguinal and scrotal hernia ‘ . - 299 28. * pelvic hernia . 7 . fs + 300 29. Operation for impervious anus . . : 3 - 812 30. Paracentesis abdominis 2 . * s . » 3820 31. Auscultation . . . . . : . » 324 32. Percussion . 7 . : F . . - 826 33. Operation for pharyngeal polypus. . . 2 - 330 34, Tracheotomy . . . . . . . - 331 35. Laryngotomy. 7 . . . ' . + 332 36. Pharyngotomy . . S . . ‘ « 883 37. 38. 39. 40. 41. 42. 43. 4A, 45. 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58 70. val 72. 73. 74, 75. 76. 77. 78. 79. 80. 81. 82. LIST OF SURGICAL OPERATIONS AND DIAGNOSTIC MEANS. xxiil “Mulling,” or pnchitiilasts, 446 ; lashing,” 447; with elastic band, 448; with hot iron, 448; scraping, 448 ; ligature, 448; torsion, 448; “ tearing out the testicles,” 449; with the écraseur, 449; with the clamps, 449; covered operation, 449. PAGE Fumigations in parasitical bronchitis ‘ ‘ . . 340 Paracentesis thoracis or thoracentesis : : . . 348 Testing for albumen in albuminuria - . . » 354 Operation for. renal calculus é ; s . . 857 Passing the catheter : . F . . 3859 Lithotrity, lithecstasy, and lithotomy . % * 863 Operation for urethral calculus. ; . ‘ . 3865 Amputation of the foot . 4 . . . . 884 Shoeing ‘ s : s . “ - 385 Removal of worm from theeye . - . ‘ 391 Delivery of hydrocephalic calf . ; - . 398 Trephining for Coenurus cerebralis . . . . - 401 Neurotomy ‘ : . . ‘ . - 414 Periosteotomy . . . . e : . 417 Setting a fractured bone . . . « 421 Operation for dislocation of abaivetan fasartx , 7 « 425 Reduction of a dislocated patella . ‘ ‘ . - 428 Means of checking hemorrhage. . 5 . + 432 Treatment by means of sutures. ‘ . - 434 Antiseptic surgery, or “ Listerism ” . . . + 435 Surgical removal of a tumour ‘ : F . 443 —69. Castration 7 . . 446-450 Ovariotomy, “spaying” . . . * 7 « 457 Signs of pregnaney . . . . . - 461 Cesarean operation . . . . : . 464 Signs of parturition . : . . . - 465 Removal of the foetal membranes . + 465 Management of a parturition case with connie ‘srouentatfod - 467 Ditto, abnormal : . - 468 Operations for hydrocephalus donpen tats sei aseitnd . - 475 Embryotomy . : . : . - 478 Operation for stricture of os uteri . . ° - 483 Operations for torsio cervicis uteri . _ e - 484 Restoration of uterus in prolapsus ‘ . . - 491 Amputation of the uterus . ' . ° . 494, oonrowond = LIST OF TABLES. PAGE . System of record of cases ‘i . ; . 7 7 6 . Agents whichare administered internally . és : « 682 . Ditto, externally . . . a . . - 86 . Classification of poisons . 2 . . 3 + 204 . Parasites (after Cobbold) : ° . . g - 222 . Classification of skin diseases . i . . . . 866 BOVINE PATHOLOGY. CHAPTER I.—INTRODUCTION. Srctrion 1. Diszasz is a departure from a healthy condition, and is consequently modified in its characters and effects in animals of different species by special anatomical and physiological peculiarities. In by far the larger number of cases functional disorder is present, dependent on structural changes, and it seems that, with the improve- ments which will be made in our methods of minute examination of tissues in health and in disease, we shall in direct ratio find that diseases supposed to be purely functional are due to alterations in structure. This has already been done in many cases, and we may take it as a law, sufficiently proved for working purposes, that disease is a departure from healthy structure of constituents of the body. These constituents of the body are elements, such as cells, fibres, membranes, and granules, which are combined together to form tissues, which produce by union in various ways the organs which co-operate to accomplish the various processes essential to life. In the highest animals these organs are collected into systems for the accomplishment of the various functions which high complexity of vitality necessitates. Thus, in pathology, we have to deal with elements, tissues, organs, and systems, and all of these are bound together so intimately in the animal mechanism, that alteration of any one of them tends to throw the body into an abnor- 1 2 BOVINE PATHOLOGY. wal state. Alteration of structure as present in disease is often brought about by changes from ordinary states of parts in situation, relations (either among themselves or with foreign bodies), andform. Such changes may result occasionally from inherited and other intrinsic influences, but are almost always due to agency from without. Every living being is adapted to certain external conditions, and is capable of undergoing modification in accordance with any variations which these conditions may show within certain limits ; but the complexity of organisation in such an animal as the ox requires gradual transitions, or dis- order ensues. Thus, we generally seek the cause of any attack of disease in changes of surrounding agencies, as weather, food supply, &c. This branch of study is termed Erronoey. Causes are predisposing or exciting. The greater the amount of activity in a part or animal the greater the liability to disease. Thus may be explained a-number of facts, such as that highly organised animals are most often diseased, when we develop one system specially for economic purposes it most frequently of all the body systems is liable to disorder, and the most active body tissues are similarly susceptible. But apart may be in such a highly active condition and yet able to do its duties, until some sudden change disturbs its relations with surrounding parts and alters its structure. These states of verging on disease are termed Prupisposine Causes. Thus, the milch cow is predisposed to mammitis, and the fattening ox to diseases of the digestive apparatus. By an extension of meaning, predisposition has come to imply also liability to disorder from any external surrounding conditions ; thus, we hear of predisposition to choking in the fact of animals being fed on improperly prepared turnips, and to hair accumulations in the rumen, as a result of the habit oxen have of licking themselves and each other. Determination of all predisposing causes present is highly necessary, for counteraction of them is essential to success in treat- ment. By some authorities intrinsic causes are termed Predis- INTRODUCTION. 3 positions, in contrast with simple predisposing causes which act from without. Among these, hereditary pre- disposition is of great importance. When we consider that the parent transmits to the offspring similarity of external structure, with the specialities of function result- ing therefrom, we shall hardly deny that peculiarities of internal structure are also transmissible. So intimate is the connection between the various parts of the body that each must be affected by the others. Thus, the germ-cell and sperm-cell have special family characters manifested only in the product of their development. The parent and offspring being alike in most structural points, and special structure giving special liability to disease, we can understand how it is that hereditary predisposition to disease of special form occurs in such disorders as tuber- culosis and cancerous diseases. The reverse of predis- position is termed immunity. Excitine Causes are the direct producers of disorder ; sometimes they are enabled to act deleteriously in spite of the absence of predisposition, but generally they find certain favouring states, so, the cautery always arouses diseased action, but a mild external stimulant may simply arouse the activity of the part to which it is applied; the latter, however, becomes an active promoter of mischief when the part is already in a disordered state. Removal of the cause, of all causes, is the grand principle in treat- ment of disease. Our inability to draw a sharp line of demarcation between health and disease is a direct result of deficiency in our acquaintance with structure and function. We cannot yet tell whether structure exists in the protoplasmic contents of cells; and when we see that a white blood-corpuscle is capable of exhibiting all the properties of life, we cannot doubt that profound secrets of nature, as carried on in the laboratory of cell structure, remain yet to be explored. Diagnosis oF Disuasz is determination of the seat and nature of a malady. An animal is brought to us “ill,” as manifested by certain symptoms. ‘These may be general or special. All animals have certain ways of 4 BOVINE PATHOLOGY. showing that they are unwell, and we shall have to notice such among bovines. These depend upon special structural or physiological peculiarities, so that one of our earliest duties will be to indicate these as distinctive of the ox and his allies. These general symptoms are often the first which appear, and then are pREmMoNITORY; they do not always persist throughout the attack, being obscured by special symptoms in many cases. They especially come under the notice of caretakers of animals, and the value of such depends much upon their ability to mark at the earliest stage departure from the usual habits of the animal. Stans, Diacnostic or Spectan Symptoms, serve either to enable us to determine the seat or nature of a malady. They may be simply manifested in the diseased part or parts, but we often find that local disorder becomes systemic, as a result of the close relations existing between all parts of the body, especially in their functions. Systemic Symproms are found in inflammations and debilitating diseases, for example; they prove useful in determination of the nature of the disease, but observation of Loca, Symprroms is essential to complete diagnosis. The latter indicate to us what parts must be especially affected by treatment, the former show us what the nature of the remedial means must be. Sometimes the systemic sym- ptoms are present, but no local indications can be observed. This occurs in “ blood diseases ”’ in which the blood, a tissue with liquid intercellular substance, being circulated in every part of the body, gives a generally diffused mani- festation of disease, which is the condition known as fever. Some practitioners err in treating only symptoms. In each case these must be taken merely as indications of the conditions of the diseased parts. Any clue they give as to the causes which produced, or tend to continue the dis- ease must be specially noted; for, our aim in each case must be to “ remove causes that effects may cease.” Such is the accuracy of mechanism in the economy of a living being that it returns to true working when disturbing INTRODUCTION. 5 agencies no longer act. In the diagnosis of disease COMPLICATION is an important element. As a rule, we have to do with disease of more parts than one, and have to come to a clear understanding in each case, for the dis- ease which causes the others, the PRIMARY DISORDER, must be that against which our medicinal efforts are directed. If we succeed in removing it, SECONDARY DISEASES result- ing from it will generally disappear. Thus, dropsy is a secondary condition often dependent on heart disease. Secondary pathological conditions may be due to co- operation in function, or to continuity or contiguity of structure. The instance just given illustrates the first method, for the dropsy results from escape of watery con- stituents through the walls of the overloaded vessels which cannot perfectly pour their contents into the heart. Ex- tension by continuity of structure is seen when the pleura becomes involved by extension of disease which originated in the lungs. Contiguity is less frequently a means of spread; sometimes we see a gangrenous patch on the wall of a serous cavity opposite a gangrenous portion of a contained viscus. This means is also exemplified in joint diseases, and wherever living cells lie together without or- ganic connection. Occasionally we find in a special disease some symptoms by means of which its nature may be at oncedetermined; such a symptom is termed Parsoanomonic. Thus, the presence of the anthrax Bacillus im the blood is pathognomonic of charbon, and the changed condition of the urine similarly enables us at once to determine the presence of heemo-albuminuria. The History of every case of disease should be ascer- tained with the utmost care, and when possible a written record should be kept for future reference. It should comprise all ascertained particulars of the case, from its commencement to its termination. It will prove not only a more sure guide to diagnosis and prognosis than the memory, but will enable the practitioner to perform his duty to the profession in recording the case if it prove interesting. We can never be assured of the professional value of a case until it has terminated. Much of the 6 BOVINE PATHOLOGY, value of good cases is often lost from paucity or inaccu- racy of records of the early stages. In each case a regular system should be adopted; dates especially should be insisted upon, and all records should be made at once. We have found the following a satisfactory system of record: Date of admission Date of Case, Colour. Sex. Age. totreatment. discharge. Disease. Progress. Pulse, State of the blood, if any has Respirations, hos special chart. been removed. Internal temperature, Conditions of mucous mem- Excretions, branes. Appetite, Temperature of surface of body and condition of the skin. Special features of case. The Putsz is due to periodical enlargement of arteries such as results from their distension with blood in con- sequence of the heart’s beat. It is one of the most useful indications of the state of an animal’s health, and can be taken at any accessible artery ; but, under ordinary circum- stances, we utilise for this purpose only such vessels as are but slightly separated from the surface of the body, and are so placed in relation to hard structures that they can be compressed against the hard adjacent tissues by the fingers, and thus their beats rendered perceptible to the observer. These beats vary in number with the heart’s contractions, and are perceptible sooner after the heart’s beat in vessels near that organ than in those more remote. They depend upon the conditions of the arteries as well as of the heart, and the vessels passing from the heart are so constructed that the pulse is less marked in the smaller arteries than in the larger ones, even rela- tively, and disappears in the smallest of these vessels. The sphygmograph is an instrument used to obtain a written record of the condition of the pulse; it has not yet been applied to Bovine surgery. The pulse assumes various characters according to its rapidity of beat, frequency of occurrence, resistance to pressure, regularity, and per- ceptibility. Thus we have the quick and slow, frequent and infrequent, hard and soft, full and imperceptible, large and INTRODUCTION, 7 small pulses, the characters of which may be determined from their names, also that form known as the intermittent, either regular or irregular. In the latter case the beats and intervals are uncertain, in the former at regularly recurring intervals the pause is prolonged. The dicro- tonous or double pulse is found in blood diseases; it consists in a double rise of the arterial wall for each beat of ‘the heart; physiologists debate its nature; it is a symptom of importance. ‘The thready pulse is extremely small, and scarcely perceptible. The “ running down” pulse occurs just before death, especially in cases of hemorrhage, and consists in rapid loss of force of beat, with increasing frequency, until the pulse becomes imper- ceptible. It is a very grave symptom. The “venous pulse” is a sign of which we shall make use when treating of heart diseases. The sharp beat of the ‘quick ”’ pulse must be distinguished from the increase in number of beats per minute characteristic of the “frequent” pulse. Sometimes the enlargements of the _ artery vary in successive beats, then the pulse is termed unequal, while extreme irregularity, and difficulty in perception and appreciation of its characters constitute the confused beat. The oppressed beat is prolonged and not very marked, while the vessels are much distended. We are not desirous of drawing attention here to. the exact method by which these conditions of the pulse are produced, but will merely state that variations in frequency and rapidity of beat are connected directly with the action of the heart, and, therefore, especially dependent on states of the nervous system and fever, inducing rapidity, and certain brain disorders, reducing the beats below the normal number per minute ; while the quick pulse shows an irritable state of the heart, slowness of beat often de- pends on impediment to egress of the blood. Hardness and softness depend upon the tone of the arteries, which consists in slight persistent contraction of their white muscular fibres adapting them to their contents ; while largeness or smallness depends upon the amount of blood in the arteries, resulting from the state of supply from fee aye Ole ee pete | pe 8 BOVINE PATHOLOGY. the heart and outfall into the capillaries. With largeness of the pulse may be associated hardness, constituting the “corded” beat; the “wiry” pulse is small and hard, and a soft pulse may be large or small. The complicated vaso-motor mechanism, by means of which these variations in the states of the artery of the living subject, together with the intrinsic and extrinsic nervous mechanisms of the heart are brought about, are explained in all modern works on physiology. We have given enough information ‘to enable us to complete our remarks on this point, by observing what states of our patients may modify the pulse. The beats vary with age, being generally frequent in very young animals and declining until old age ; somewhat more frequent in the female than the male, they are especially increased by conditions of pregnancy (varying with the stages) and lactation. Individual temperament may affect the number, but especially alters the character of the pulse. The nature of the animal’s work and mode of life, as also various processes of digestion (especially rumination) and some minor influences also affect the pulse. The Rzsprratory System, by means of which much impure matter is removed from the blood and much oxygen is added to it, gives us indications of importance, as serving for diagnosis and prognosis of disease. Varia- tions occur in the manner of introduction of air into the lungs, and of its expulsion after utilisation, also in the frequency of these processes. The extent of this system renders it liable to become affected by contiguity to many parts. Also its nervous connections are of considerable importance. Hence, in every case we should examine the number and kind of breathing efforts, and we shall often find it necessary to note the presence and character of a cough or other sound produced by respiratory acts. . It has been observed that under healthy conditions the pulse and respirations bear to each other a definite numerical relation, one to four, but this is hardly exact. Fevers, inflammations, and other diseased conditions affecting the system, cause increased frequency of breathing. INTRODUCTION. 9 Respirations consist of two acts, inspiration and expiration. The former is brought about by elevation of the ribs, and contraction of the diaphragm—both acts of muscular exertion. The effect of contraction of the diaphragm is to lessen its concavity towards the abdomen, hence it presses on the abdominal viscera and causes bulging of the walls of the belly. Expiration under - ordinary circumstances depends upon elastic recoil of the elevated walls of the thorax, resulting in expulsion of air through the trachea and larynx. Respirations vary with their depth, frequency, quickness, facility, and the nature of the movements by which they are brought about. Thus, they may be quick or slow, frequent or infrequent, deep or imperfect, laboured, unequal, irregular, &c. Dyspnea is a term used to imply difficulty of breathing of any kind. Apnea is the extreme of infrequent respiratory effort, dependent upon the circulation of highly oxygenated blood through the medulla oblongata, where the respira- tory centre resides. Until its natural stimulus, venous blood, is supplied to this centre, no respiratory effort will occur. OrrHorpn@a is that condition in which difficulty of respiration is marked except when the animal is in a standing position. Aspuyxta (literally pulselessness) is a complicated con- dition due to insufficient supply of air for respiratory purposes. It commences as dyspnoea, convulsions with violent expiratory efforts succeed, and, finally, exhaustion sets in, leading to death. In the later stages of asphyxia the animal is stretched out in a recumbent position, with dilated pupils, loss of general sensibility, scarcely per- ceptible pulse, visible mucous membranes dark purple in colour, respirations deep and slow. Finally, he gasps for breath, extends the limbs, shudders, and dies. And on post-mortem examination the lungs, right side of the heart, medulla oblongata, and various body tissues are found in a state of venous engorgement. Lungs, heart, and medulla are all concerned in the fatal result, 10 BOVINE PATHOLOGY. neither of these organs being stimulated because of the deficiency of oxygen. Inhalation of such heavy gases as prevent access of oxygen to the lungs, suffocation, and many other diseased conditions bring about death in this way. Sometimes the expulsion of air from the lungs is laboured, and accompanied by a harsh rattling sound; the breathing is then said to be Srmrrorous. It depends upon the movement of velum pendulum palati by the expiratory current, and may be observed in cases of parturient apoplexy, for instance. Coven is brought about by a deep inspiration, the glottis is then closed until the outward current of air suddenly forces the vocal cords apart, when the air escapes with a sharp sound, and emerges either through the nostrils or mouth with some force, carrying with it any foreign body, such as a mass of mucus, &c., which may have been about the glottal opening. Cough depends upon reflex nervous action, and may be primary when the irritation exists in the lungs or air passages, or secondary, when due to irritation of the stomach, intestines, or other parts having nervous communications with the respiratory apparatus. We speak of harsh, difficult, paroxysmal, suppressed, and other coughs which do not require special description. Some coughs are considered pathognomonic signs, such as that of pleuro-pneumonia azymotica, Oxygen introduced by the process of respiration into the blood is the grand agent in the production of animal heat. It combines with various matters, whether in the blood or in the other tissues, and produces with them carbonic anhydride and water (which are passed off by excretory organs, espe- cially the lungs) and heat, which enables the several parts of the body to perform their functions. Observation has proved that for each species of animal we may determine a standard internal temperature, which proves useful in the diagnosis of disease, especially when of an epizootic and contagious character; to a slight degree indi- viduality modifies the readings. Thermometry is now gene- rally practised and many valuable results have been obtained INTRODUCTION, 11 from it. The clinical thermometer (self registering) is the instrument used, and proves a most valuable aid to the veterinary inspector of contagious disorders. The vagina, mouth, and preferably the rectum, are the seat of insertion. The instrument requires to be “ set ” to near the expected reading, as by warmth from the hand, to be introduced a short way and then moved farther in, and to be rested against the walls of the cavity for about three minutes, These precautions are mentioned, as neglect of them may lead to imperfect observation. Ordinary -physiological influences as exercise, digestion, &c., give rise to slight variations of internal temperature, but a rise of 2° or 8° is sufficient to lead us to suspect some febrile disturbance, and it has been found that a rise of the internal temperature is the earliest perceptible indication of various eruptive fevers. It therefore is a valuable indication of the advisability of separation when it occurs in animals which have run risk of contagion. A marked fall in temperature below the normal occurs in most cases shortly before death, and a low temperature is observable in typhoid fever and other diseases of a low or asthenic type. When this instrument is not available we must resort to the usual methods of investigation of the surface temperature. OColdness or the reverse of the extremities, of the mouth, of the expired air, must be estimated by our sense of touch, while care is taken to note any variations of these points, either at different times or at one and the same time among similar members. Any tendency to coldness or unequal temperature of these parts must be viewed with suspicion, as indicating deficiency or perversion of the blood | supply whereby heat is diffused throughout the body. Excessive warmth indicates febrile conditions. A fall in temperature of the surface is generally a precursor of death, so we often read of “deathly coldness of the extremities.” The conditions of the skin also require attention, it is the principal regulator of internal tempera- ture, and the effects of its disorder are well seen in the rise of the mercury in fever cases. Its supply of blood and its nervous organisation are very marked, so it-is 12 BOVINE PATHOLOGY. liable to disorder, and very early indicates systemic disease. It varies under diseased conditions in its moisture and smoothness as well as temperature. We see it dry and harsh, with an erected condition of its hairs, “staring,” as it is termed, in most disorders. It may be bedewed with moisture, locally or generally, as a result of pain. While coldness with dampness—“ cold sweats ”’—are a sign of approaching dissolution. The mucous membranes exhibit variations in conditions visible to the eye, and thus serve to supplement the conclusions arrived at from the state of the skin; they become. reddened in fever, purple in certain morbid conditions of the blood, pale in low fever and other debilitating con- ditions. The various excreta should be most carefully examined as to their quality, quantity, and mode of expulsion. Each excretion has a definite normal composition as ex- hibited by certain physical and chemical characters. Odour, appearance (including colour, form, and arrange- ment of components), consistence, and in some cases even taste, exercise the special sense faculties of the observer. Specific gravity is especially altered in the fluid matters given off from the body, such as urine and milk; it is tested by modified forms of the hydrometer, or by sp. gr. balls, which sink or float according to the density of the liquid in which they are placed. The faces and urine should be subjected to physical and chemical tests. Sweat, saliva, and especially milk should be likewise examined. We shall hereafter note the special features of various excreta and secretions as altered by disease. Among other ejecta the expired air must not be forgotten ; its odour often leads to diagnostic inferences. Micro- scopical examination enables us to determine whether those constituents of excreta which have a definite form present their ordinary characters, and are in proper pro- portion. The microscope is a most useful aid to diagnosis, and as having a wide utility may be here mentioned. Moderate powers, as the $-inch and }-inch by good makers, are sufficient for ordinary diagnostic purposes. The blood INTRODUOTION. 18 may be obtained for examination in any case; its charac- ters in such disorders as leuceemia and anthrax are diag- nostic. Morbid products of various kinds, as discharges from membranes and new growths, may disclose their nature to the microscopical observer. . Parasites, as ova, immature forms, or adults, may by this instrument be proved to be present in active disease reasonably attri- butable to them. The spectroscope is now used by pathologists and physiologists; its application to veteri- nary surgery affords an untrodden path to reputation for some future observer. In our examination of the patient we require next to examine the special features of the case. The indications derived from the observations above mentioned are usually of a general rather than a special character, and at every stage of the examination we must endeavour to determine whether the conditions observed are due to local or general disorder ; the special features of the case have generally somewhat of a diagnostic character, so much so that from the messenger sent to request our services we may some- times learn the sort of case which we are about to take in hand. ‘The popular names of disorders are not without their use (thus farm labourers can understand the nature of “ dropping after calving ”’ to a certain extent), and though not always correct, will enable the practitioner to select such instruments and medicaments as are most likely to be urgently required. Some means of determination of symptoms with a view to diagnosis are special in their application. Thus, men- suration, auscultation, and percussion will be considered when treating of diseases of the thoracic viscera. These means, nevertheless, have somewhat a more ex- tended application; thus, auscultation has been recom- mended for determination of the presence of a foetus in utero, and it is a most important means in diagnosis of deep- seated fractures, while percussion assists in the distinction of tympany from impaction. We must especially lay stress upon the value of MANUAL EXPLORATION, either by introduc- tion of the lubricated hand into the rectum, vagina, or 14 : BOVINE PATHOLOGY. mouth, or by manipulation of the surface, whereby we are enabled to ascertain by touch the form of superficial structures, their relations, and size, determining whether these are normal or abnormal. Their consistence is de- tected by palpation, skilled touch. The “ tactus erwditus” reveals many obscure states, such as deep-seated ab- scesses, aneurisms, &c. The ophthalmoscope and other valuable instruments are limited in their application. The exploring or grooved needle must be mentioned here, for its value in deter- Fie. 1.—Exploring trochar (used for the same purpose as the grooved needle). mining the contents of fluctuating swellings, cavities, and the constituents of, tumours. It is so small as not to seriously injure the parts into which it is introduced. Its groove or cup brings up sufficient material for micro- scopical examination. It is to us what the dredge is to the deep-sea explorer. It must not be supposed that the methods of observing symptoms suggested by us require to be all adopted in every case. Our aim is to ensure systematic examination of those symptoms of disorders which from their general prevalence may be deemed of minor importance. The determination of the seat of dis- order will suggest to us which of the less general aids should be adopted in any particular case. Prognosis must depend upon extended diagnosis. It too frequently assumes the character of simple guesswork or of empirical surmise. The practitioner should in fancy “see through” his patient, should know what parts are diseased, their pathological conditions, with the possibility of renovation, the resisting power due to constitutional energy of the patient ; also the probable influence of medi- cinal means. He must note how the disease tends to inter- fere with essential vital functions, and especially its influence upon the “ vital trio,” the brain, heart, and lungs. INTRODUCTION. 15 Duarte may be either systemic or local. This is a direct result of the composition of the body of cells bound to- gether to form a complicated mechanism. Local death is of two kinds, molar and molecular. In the latter form cells die by themselves and at different times, and thus a gradual loss of tissue occurs; the former results when a number of cells and other tissue elements simultaneously succumb to some injurious influence. Ulceration is molecular, gangrene is molar death. Local death results from systemic as soon as the amount of nutritive material supplied to each tissue by the last blood which entered it has been exhausted. So the most active tissues die most readily, while less highly-organised parts retain vitality for some time after systemic death. It must be remembered also that the life of each part of the body varies in its duration,and that in the course of life of such an individual as an ox, every element of a tissue is not always the same, but consists of a number of short-lived minute bodies which succeed one another. The blood is the most important bond of connection between all the body- cells. Of the value of the nervous system in this respect we are not so assured. ‘The action of each cell depends upon a due supply of fresh blood containing nutritive matter. Cessation of the circulation of the blood is in every case the immediate cause of death. ‘The failure of the heart may arise in itself, on account of some failure in its nervous or muscular elements, or by reason of some mischief affect- ing its mechanical working. Or it may be due to some fault in its internal medium, such for instance as a want of oxygenation of the blood, which in turn may be caused by either a change in the blood itself, as in carbonic oxide poisoning, or by a failure in the mechanical conditions of respiration, or by a cessation of the action of the respira- tory centre. The failure of this centre, and, indeed, that of the heart itself, may be caused by nervous influences proceeding from the brain, or brought into operation by means of the central nervous system; it may, on the other hand, be due to an imperfect state of the blood, and this in turn may’ arise from the imperfect or perverse action of 16 BOVINE PATHOLOGY. various secretory or other tissues. The modes of death are in reality as numerous as the possible modifications of the various factors of life; but they all end in stoppage of the circulation, and the withdrawal from the tissues of their internal medium” (Foster). The following methods of death may be remembered : Death from Anmmia, due to cessation of blood-supply, as after profuse hemorrhage. The symptoms observed in such cases are running down pulse, respirations irregular, pallor of visible mucous membranes, coldness of extre- mities and of general body-surface, which may be bedewed with cold sweats; dilatation of the pupil, and loss of sensibility of the retina; loss of voluntary power, and, finally, convulsions. The first vital organ which fails in this case is the brain. The recumbent position, therefore, tends to prolong life by mechanically keeping up the supply of blood to that important organ. Transfusion of Blood has been successfully resorted to in such cases in man. It is a dangerous operation to the healthy animal from which the blood is taken. It has been accomplished experimentally in the lower animals by connecting the carotids of two individuals by a tube, such as an ureter (Percivall). Thus, it has been proved that ~ the blood must be from individuals of the same species. Death from Nucrmmia occurs in blood diseases where the vital fluid has lost the stimulating power by which it excites the heart to action, as a result of putrid decom- position. Death by Asruenra is sudden cessation of the heart’s action, and may be due to poison or shock, as in lightning injury. After death the right side of the heart is found to contain venous and the left arterial blood. This form of death is also known as syncope, but this term is generally also applied to ansemic death. Asthenia sometimes occurs gradually, then the pulse becomes irre- gular, and the blood supply to distant parts of the body is defective. This culminates debilitating disorders. Death by AspHyxta has been elsewhere described. Apnea does not cause death, it accelerates life, INTRODUCTION. 17 Death by coma commences at the brain. The sym- ptoms present are, firstly, those due to deficiency of cere- bral energy, loss of sensation and power of voluntary motion, stupor, with slow stertorous breathing, and later the medulla becomes involved, and the respiratory centre ceases to perform its function, and the right side of the heart becomes blocked up with dark blood. Apoplexy causes death in this way. Prolonged artificial respiration may enable the medulla to regain its energy, as when coma results from certain poisons. Our prognosis requires especially diagnosis of the patho- logical conditions of the diseased parts, and makes a knowledge of MoRBID ANATOMY, sometimes termed INTIMATE PATHOLOGY, a matter of the highest moment. The ana- tomical changes which occur in organs during the progress of disease vary according to the structure of the parts and to the nature of the diseased action. The objects of morbid anatomy are to determine exactly the changes which structures undergo as a result of diseased processes, how those changes are related to each other, how their causes have operated to produce them, and how they are liable to affect the wellbeing of the animal. The methods of morbid anatomy comprise examination of all organs, tissues, and elements which have been altered by disease. These parts may be procured in many cases from the living animal, but in others only on post-mortem examination. They require to be subjected to all available processes, physical, chemical, microscopical,—indeed, the study of morbid anatomy is but a branch of diagnosis—the exten- sion of its methods as above enumerated. Our determi- — nations of the changes which have occurred in an organ are only made in some cases after death, and the infor- mation thus gained must be applied at an earlier stage of future cases. The changes which structures undergo: during disease may be in situation, structure, form, and size; also it seems that in some cases their function may be changed either by increase, decrease, or perversion without appreciable alteration in structural characters. Displacement of elements, tissues, and organs results in 2 18 BOVINE PATHOLOGY. interference with function when such displacement also causes change of structure. Thus, most of the non-malig- nant tumours are said to consist of normal tissue-elements out of place, and may exist without seriously disturbing vital ‘functions until their bulk causes them to interfere with neighbouring parts in a purely mechanical manner ; and as soon as structural changes of these neighbouring parts causes them to become secondarily involved, the disease as- sumes a more urgent character. Again, a displaced bowel in a case of hernia causes no inconvenience nor true patholo- gical condition until it becomes strangulated, and thus structurally disordered. Displacement simply of tissues seldom occurs. Ohanges in size of a tissue-element may be of increase or decrease, and these may be due to altera- tion of constituents, or to simple variations in their quan- tity. The various degenerations are changes in consti- tuents generally either of a retrograde or a retrospective character. To understand this, we must recall to our minds the elementary structure of the body. It originates as a simple cell, or even earlier, perhaps, a simple mass of protoplasm. This cell is endowed with all the properties of a living organism, dependent upon the high vitality of its protoplasm ; hence it exhibits the phenomena of irritability, contractility, spontaneous power of movement, and repro- ductive energy. All the elements of the adult body are lineal descendents of this primitive element, but each has progressed in a special line; hence, in a muscle-cell con- tractility is the prominent property ; in a nerve-cell spon- taniety or irritability, and in white fibrous tissue-corpuscles probably the control of local nutrition. Under certain diseased conditions, each of these forms of cell is liable to regain some of its lost or dormant powers; thus, the tissue-corpuscle becomes a reproductive cell, and proli- ferates freely in suppuration; the muscle-cell exhibits spontaneity. Such are retrospective degenerations. Re- trograde metamorphoses are much more frequent, the principal being mucoid, colloid, and fatty degenerations. Mucor Dscenzration consists in such an alteration of the tissues that they assume a mucus-like character. It INTRODUCTION. 19 is considered to be generally a retrospective change, whereby the primitive characters of the tissues aro resumed ; it occurs especially in connective tissues and cartilages, affecting generally the intercellular substance. CotLo1 Duaenzration depends upon the conversion of the protoplasmic contents of cells into a tenacious jelly- like material. The cells are burst by accumulation of this matter, and considerable lumps of gelatinous material are produced. The thyroid body is the most frequent seat of this change, but both mucoid and colloid changes may cccur in tumours, whether of a malignant or non- malignant type. Neither of these has any bearing of importance upon cattle pathology, though we shall find it occasionally necessary to allude to them. Farty Dsceneration is extremely liable to occur in organs which have nerve or blood supply interfered with, for it is a retrograde process resulting from deficient supply or appropriation of nutritive matter. It is a conversion of the contents of the cells of a tissue into fat, which may accumulate so considerably as to burst the cell-walls, whereby a secondary process of diseased action h Niele gier | 19 Oop Bn 2 Celi” ° ons a oS OB Glee 4 G Oo” 0 WSN Te a af 70D, Be 93] S316] a 200% e Ey 8 > dose Fig. 2.—Fatty degeneration of the Heart. x 200 diameters. After Harley and Brown. occurs. It affects especially the muscles, as also the lining membranes of arteries and the bowels (in which case the epithelial cells are involved). This process is of very considerable importance, for it occurs often when a morbid product is to be absorbed and passed into the blood. Sometimes casEOUS CHANGE supervenes upon this 20 BOVINE PATHOLOGY. form of degeneration, the part affected becoming a mass of substance of a cheese-like character, yellow in colour, inelastic, and rather soft. Tuberculous deposits are very liable to undergo this change, as also certain malignant growths. Catcarzous Cuancz depends upon the deposition of lime salts in the intercellular substance of a tissue, whereby it assumes a gritty character and becomes opaque and resistant. It occurs very frequently as a result of excessive activity of the process which normally hardens the costal and laryngeal cartilages of old animals, and is a means by which deposits are rendered permanent and prevented from absorption. These processes of degeneration take place normally in certain parts of the. body, and when they occur in disease are either in excess in normal situations, or in abnormal sites. The mucoid and colloid degenerations tend to softening of tissue. Fatty degeneration places the matter in that condition under which it is most fit for removal. Caseous change tends rather to per- manency, while calcification exhibits this to a still more marked degree. The calcareous change generally as- sumes the character of an INFILTRATION, involving intercellular tissues rather than the cellular elements of a part, and resulting from the deposition of matter from the blood instead of its production as a result of change in the protoplasm of the cells. Fatty infiltra- tion is very common, involving such organs as the liver and muscles (especially the heart) in animals fattened for slaughter. This proves prejudicial when the accumula- tions of fat pressing upon the tissue elements of the affected part impair their nutrition. Accumulations of fat of this nature occur physiologically in the processes of fattening, then the connective-tissue corpuscles are affected, and this very frequently occurs also in disease. Picmentary Inrinrration especially affects the lungs of old animals. _ Amyzorp Iyrinrration has been observed in the liver, and consists in the deposition from the blood of a starchy INTRODUCTION. 21 material, which gives to the organ in which it occurs a waxy character. The process generally commences in the small vessels of the part. It has not been found, as yet, to have much clinical importance. Special chemical, microscopical, and physical tests enable us to determino the presence of these changes in parts. These will be found recorded in more special works. Fatty, calcareous, and pigmentary changes, when sufficiently advanced to produce serious disorder, can readily be detected by the unaided senses of the observer. Let it be clearly under- stood that all these degenerations and infiltrations are physiological processes in excess or out of place; they may also be deficient, as occurs in rachitis where there is deficient deposition of lime in the bones. They result from perverted states of nutrition, dependent upon con- ditions of the blood or of the cell-elements themselves. Certain forms of degeneration lead to increase in the sizo of organs, and very considerable modification of form. _ The tissues are so arranged as to form solid or hollow organs. When the former are the seat of changes their increase in size and change of form cause them to press upon neighbouring parts, and thereby interfere with functional duties; or softening with rapid enlargement may lead to rupture, as is sometimes seen in the liver. It must be remembered that very considerable degeneration of an organ may occur without alteration in bulk, increase in size of some parts atoning for diminution of others, and vice versd. Here we have a case of degeneration with atrophy. When a hollow organ is involved in these degenerative processes they may lead to thickening of its walls with or without diminution of its cavity, or to thinning of the walls—atrophy—a condition which, with concomitant softening, tends to produce rupture. When an organ is subjected to free supply of nourishment, with high functional activity, it becomes HYPERTROPHIED, this condition consisting of an increase in the number (hyper- plasia) or size of active tissue elements; such a change must be carefully distinguished from other forms of enlarge- ment. It occurs often as a provision against disease ; 22 BOVINE PATHOLOGY. thus the bladder may have its walls thickened when any obstruction in the urethra interferes with the passage of urine. The reverse of this is ArropHy or wasting, which is described as of two kinds, simple and numerical. The former depends upon decrease in size of the proper elements of a tissue dependent upon deficient supply of nutritive matter, the latter is a more advanced stage of the same state in which actual removal of tissue elements has occurred. Atrophy may result from an imperfect supply of blood or from imperfect ability to appropriate nutritive matter, such as often results from inflammation. It may be difficult to ascertain this state from simple inspec- tions of organs, for as the useful elements are removed the connective elements may be increased in quantity, or dis- placement of some material into the organ may serve to maintain its size. The ADDITIONS OF MATERIAL TO AN ORGAN in almost all cases take place from the blood, and hence have the character of infiltrations. They may be solid, liquid, or gaseous. Liquid matters most frequently over- flow from the blood, or are removed in excess from that fluid by over-excited tissue elements. They contain solid matters. in solution, and as their fluid portions are most readily removed by absorption, solid deposits may remain behind. These latter either become organised by exten- sion of vessels into them, undergo calcareous change and become permanent (but in the condition of foreign matters), or undergo retrograde changes, especially the fatty, and become absorbed. We shall have more to say about these processes when treating on inflammation. Accumulation of liquid added material constitutes Dropsy. Gas sometimes occurs in a tissue either as a result of gangrenous change of the tissues (the blood for instance) as in black quarter, or as a result of ill-explained nutri- tive changes in a part, or entry of air through an external or pulmonary wound. The gases which occur are such as normally exist in the blood or the atmosphere. Having dealt with the general changes which structures undergo as a result of diseased processes, we must next examine the characters of those processes themselves, INTRODUCTION. 23 PaiecMon or INFLAMMATION is defined to be “ perverted nutrition of a part resulting from the application of a stimulus not sufficiently powerful to cause immediate death.” It is a familiar but complicated series of pheno- mena of the highest pathological importance, since it occurs in all tissues, and varies considerably according to its seat. We may consider it is nature’s method of rising to the emergencies of injury, whereby repair is brought about. Tn all cases it seems to follow injury of the part affected ; thus it ensues in the majority of cases of wounds, and originates in internal organs either as a result of local injury, or when impressions made upon the surface of the body have proved injurious to more deeply seated parts through the intimate nervous unions which occur between the structures. Of these nervous unions we are not yet assured by physiologists. It cannot be expected, therefore, that the pathologist will be in every case able to determine how any cause which he suspects of having originated internal inflammation acts. We accept this theory of the nature of inflammation since it sufficiently explains all the phenomena of that condition to afford us a good practical basis. Inflamed parts are found to be the seat of stagnation of blood in the vessels, of transudation of its fluids with migration of its formed elements, also of an altered condition of the tissue elements. Probably the latter change is the most essential, for it is marked in cartilage and other tissues which have only indirect blood supply. It consists of high reproductive activity of these cells (proliferation), the products not being so highly developed as the parent cells. The stagnant condition of the blood in the vessels is brought about gradually through certain stages. It is found, by observations of the circulation in the blood-vessels of an artificially in- flamed transparent membrane, that dilatation of the vessels first occurs with acceleration of the flow of blood, which, however, very soon becomes retarded, then irre- gular and oscillatory until stagnation—“ stasis ”—ensues. Then a large number of colourless corpuscles are found to have accumulated in the affected vessels near the walls, 24 BOVINE PATHOLOGY. while red corpuscles, aggregated into bundles, lie nearer the centre of the vessels. Migration now occurs as a result especially of the amceboid activity of the white corpuscles, whereby they are able to penetrate the proto- plasmic, and, therefore, living walls of the capillaries. Thus they, and sometimes a few red corpuscles, pass into the tissue interspaces, and intermingle with the new generation of cells produced by the proliferation of the tissue elements. At the same time the serous portions of the stagnated blood transude through the walls of the vessels, and thus originates EFFUSION as well as EXUDATION, for they are rich in solids. Hffusion of serum and exuda- tion of lymph are early accompaniments of inflammation ; they occur, to a more or less degree, in almost every case, and are the principal cause of sweLtinc. This depends, also, to a certain extent, upon the conditions of the vessels in the parts bordering on that inflamed. They are very full of blood coursing rapidly through them, are in a state of hypereemia or congestion. The presence of this large quantity of rapidly flowing blood, with, perhaps, also the rapid tissue changes in the inflamed part, generates the characteristic heat; to the congestion and amount of blood, even in the seat of disease, the REDNESS, characteristic of inflammation, must be attributed ; while pressure from effused material and distended vessels is the cause of the painful nature of the process. The pain present must also be attributed to heightened sensibility of the nervous structures. It is related to the hardness of the part, hence inflammation of unyielding organs is most painful. The reproductive activity of the tissue. elements replaces their normal function, and the rapidity of new cell formation prevents the elaboration of inter- cellular substance, hence the intercellular material accu- mulates in a state of imperfect development as fluid, and tends to increase the added liquid and plastic material which has been thrown out. Effused liquid material can be taken up again by the capillaries and lymphatics of a part with facility if the vessels have not themselves undergone change. When the latter complication is, INTRODUCTION. 25 present fluid accumulations occur, which constitute (ipema when they are in areolar tissue, and Droprsy (hydrops) when into cavities of various kinds. These may take place apart from inflammation when an excess of liquid material exists in the blood, or when the vessels are over-distended. The former condition occurs in cases of debility resulting from defective supply of nutritive matter ; also certain poisonous materials aggravate their effects by causing excessive fluidity of the vital fluid. An illustration of the latter condition may be drawn from general dropsy, whereby excessive distension of the veins is relieved when any obstruction prevents return of the blood to the right side of the heart. When the material added to a part has a more solid character, it primarily assumes the form of CoacuLasLe Lympu. Thisis fibrinous material which is deposited between tissue elements, ren- dering the parts abnormally hard, or as bands extending across cavities, also membranes lining them, and it will be noticed in the straw-coloured liquid portion of the serous effusion. When all active inflammatory change has subsided, the lymph tends either to permanency or to disappearance. It may be rendered permanent either by organisation, when vessels shoot into it by ordinary processes of development and it thus becomes vascular and in process of time somewhat like areolar tissue, or by calcareous deposition in its substance. The former change occurs in the repairs of any large gap of living tissue which has resulted from injury. It causes filling up of abscess cavities, and of deep penetrating wounds, but is not always so salutary ; for when it occurs in such a cavity as the pleural sac, by uniting the lungs to the wall of the chest, it may seriously impede respiration. Calcification is the process which normally occurs in the hardening of lymph between the fragments of a broken bone forming the mass known as callus. Its appearance is not always desirable, thus when it takes place in the walls of arteries it renders them liable to rupture, and frequently its presence acts as an impediment to movement, as when false anchylosis results from the calcification of ligaments around joints. 26 BOVINE PATHOLOGY. Supruration is that result of inflammation which is manifested by the production of the fluid which is familiar to us as pus. It results especially when inflammation runs high in a very vascular organ, but may occur under different circumstances. Pus consists of highly active corpuscles, which closely resemble white blood-corpuscles, and float in serous fluid—Liquor Puris. It has a sp. gr. of 1030. This fluid is simply the effused material with a large number of cells resulting from proliferation of tissue elements, and migration of leucocytes, This result Fria 3.—A. Pus corpuscles from an abscess; (a) the same after treatment with acetic acid. B. Mucus corpuscles from the Schneiderian mem- brane ; (a) after a drop of acetic acid has been added. C. Mucus corpuscles speckled with pigment granules from a case of chronic irritation of lining membrane of the larynx. After Harley and Brown. of inflammation is most frequent when a natural moisture of the part and capability of yielding to swelling are properties of the diseased organ or tissue. While exuda- tion most frequently occurs on serous membranes, the mucous surfaces generally when inflamed produce pus ; but pus may be produced by a serous membrane and plastic deposits by a mucous membrane, such as that of the bowel or trachea. When suppuration assumes a local character, € INTRODUCTION. 27 and the pus which is formed accumulates in the areolar tissue, it exerts a solvent action upon the white fibrous elements, and thus produces an Axscuss. Ordinarily we may observe that the inflammatory process, where less acute at a distance from the centre of pus production, causes exudation of lymph which limits the infiltration of pus into the neighbouring tissues, and constitutes the boundary of the abscess cavity, though forming no distinct membrane. This firm limiting tissue gives way with extension of suppuration, and at the same time, the parts external to it, which previously were only the seat of effusion of serum, have lymph exuded, and thus in turn prevent infiltration of pus into the undiseased areolar tissue. So, in puncturing a large or a small deep-seated abscess we pierce first tissue with serous effusion, then tissue with lymph exudation, and so arrive at the abscess cavity. In chronic abscesses the inflam- mation has subsided, as also has the serous effusion. The lymph deposit has become organised to form a wall of the abscess cavity in which has accumulated pus, often of a fetid character, but sometimes broken up into the liquid serous portion and the solid materials, the latter being converted into more or less regularly rounded and hardened masses of a curdy or cheesy character, which are bathed by the fluid. These abscesses are sometimes termed cold; they are seen in deep-seated positions where the inflammation has been only moderate in intensity. Purvuient Inrinrration occurs when collections of pus are allowed to enter the areolar tissue of an organ, either by non-deposition of lymph circumscribing the seat of pus formation and leading to abscess, or by the giving way of only a thin layer of this material. It is especially liable to occur in the less active forms of inflammation, and in organs with a considerable amount of areolar tissue ; thus, it may be observed in scrofulous disease of the lungs, and leads to rapid spread of diseased action. Sometimes pus is found in serous cavities. When the pleura is the seat of this the disease is termed empyema. This state seldom, 28 BOVINE PATHOLOGY. if ever, results from pus production by the serous mem- brane, but from bursting of an abscess into the serous sac. It has been observed that layers of fibrous tissue, fascize, aponeuroses, limit the extent of abscesses. A knowledge of the position of these is, therefore, important from a surgical aspect, for when externally placed to the pus accumulation they oppose that extension of the abscess towards the surface which leads to evacuation of the pus by bursting through the skin. The local symptoms of for- mation of an abscess are primarily hardness of the diseased parts, with an cedematous condition of the tissues around, with elevation of temperature, and throbbing of the arteries of supply ; then the centre of the seat gradually becomes softer, and at length fluctuates on pressure. The part is swollen and most prominent centrally. After this the fluc- tuation extends from the centre, where the hairs fall off, and a slight amount of serous fluid exudes until the pressure of pus in the abscess bursts the skin, which has been much attenuated by absorption, and thus the pent-up fluid escapes ; and any which forms after this also escapes, for nature has produced an opening with a jagged edge, such as does not readily close. As the pus, which is now pro- duced, exerts no pressure on the abscess-walls, a rapid closure of the cavity results from deposition of lymph around its walls, each layer undergoing changes which terminate in conversion of them, in order of seniority, into an organised tissue somewhat resembling the white fibrous. This process is termed granulation. By it, finally, the cavity is filled; then the external wound closes. Escape of pus by bursting of an abscess on to the surface of the body, or of a mucous membrane, is a very salutary process. But it may take place into serous cavities and other in- ternal spaces when the result is not so. satisfactory. Evacuation of pus from a mucous membrane is often to be encouraged as being nature’s method of relief of its in- flamed state. When pus does not become removed by natural or artificial evacuation, its permanence or the reverse will depend upon the state of the vessels of the parts, and also on whether its corpuscles undergo the INTRODUCTION. 29 retrograde process of fatty degeneration, pus-cells seem to be never absorbed. When they have undergone fatty change, and with the Liquor Puris form the so-called ParnotoeicaL Mizx, this may be taken up, just as so much ‘chyle would be, by the lymph-vessels. The blood-capil- laries probably assist, but when neither blood nor lymph- vessels can take up the metamorphosed or unchanged pus, a cold abscess results. Pus is of various kinds: Laudable, when it has a creamy, whitish-yellow ap- pearance ; is devoid of smell and rich in corpuscles. This is the form which is familiar to us as occurring in well- matured abscesses. Fetid, when it has undergone decomposition, either from a long pent-up condition, or from a depraved state of the parts producing it. Sanious, when it is thin and watery, and intermingled with blood in small quantity. Ichorous, when thin, watery, almost devoid of cor- puscles, largely made up of cell débris, and often with a marked odour, and an acrid, irritating character. This is produced in parts which are of low organisation, or have been reduced in vitality by long continued diseased action. It occurs in diseases of the feet in long standing fistulous ulcers, where the healing process is at a stand- still. Specific, when it contains the virus of some specific disorder, as when it is produced by the mucous mem- branes in cattle plague. Such pus when used for inocu- lation transmits the specific disorder. Strwmous, when resulting from the breaking down of tubercle, This is white, watery, and has specific cha- racters. Pus may be mixed with other fluids as in muco-purulent discharges from mucous membranes. The characters of Inspissated Pus which occurs in chronic abscesses have been already alluded to. Caries AND ULCERATION are processes of molecular dis- integration, which sometimes occur when inflammation cuts off the nutritive supply of a part in a gradual manner. 30 BOVINE PATHOLOGY. Caries especially affects articular surfaces of bones as well as those portions invested by fibro-cartilage. In it no tendency to repair is exhibited but the process of exten- sion of the disorder progresses slowly, and removal of the articular lamina of the bone by molecular disintegration leads to death of the cartilage which it supports, and so to roughness of a surface which for due performance of its functions ought to be smooth. Hence results secondary disease of the opposing surface, whether articular or ten- dinous. The process of caries isremarkable for the small amount of liquid product, and hence generally the absence of marked distension of the joint capsule or wall of the tendinous sheath. Ulceration is of much more general occurrence, and as removal of tissue occurs at one part, repair takes place at another. Pus is produced often in very considerable quantity by ulcers, and may be of any of the different kinds mentioned above. Ulcers are local deficiencies of structure, which generally appear on mucous membranes or the skin as breaches of the epithelial layer, with the deeper layers of the membrane more or less in- volved. In the cornea we sometimes see ulcers consisting in local deficiency of the tissue of the cornea propria, in which the conjunctiva is not involved; this is due to the fact that the latter membrane is supplied with nutriment from a different source than the cornea. As a rule, the epithelium is nourished by the deep-seated structures, and is early involved in the diseased process. We must not in all cases consider ulceration due todeath of tissue-elements ; it probably much more frequently results from cell pro- liferation, which, replacing the parent by numerous cor- puscles in a fluid medium, leads to breach of tissue, and formation of a fluid with suspended cells, which either escapes aS pus, or is removed by the action of absorbent vessels. The breaches of tissue resulting from ulceration and suppuration are repaired by Granutation. This con- sists in the production of small pointed projections over the exposed surface, which are found to be composed of cells, the deeper seated of which undergo organisation, while the superficial degenerate into pus. By their INTRODUCTION. 31 growth these projections coalesce, and new blood-vessels shoot into them from the neighbouring parts. Thus, by formation of successive crops of granulations, their fusion and organisation, the ulcer is constantly reduced in size whenever the activity of repair exceeds that of disin- tegration. Thus, also, we generally see pus produced in considerable quantity from a granulating surface; but it seems possible by means of dressings to increase granula- tion at the expense of suppuration, and thus promote rapidity of healing of a wound. The granulation tissue tends to the conversion of its cells (exudation corpuscles) Fia. 4.—Granulation tissue. (After Gant.) To the left, granulation corpuscles with rounded pus cells. To the right, the newly formed vascular loops. into proper tissue-elements resembling those of ordinary fibrous tissues. The process of cicatrisation, whereby the breach is “skinned over,” will be dealt with when we treat especially of wounds. Ulcers are of various kinds, according to their shape, products, causes, and granula- tions. — : The Simple or Healthy Ulcer occurs in animals of healthy constitution, presents small, vascular granulations, uniform in size and in diffusion over the surface, which is concave. Laudable pus is produced, and the edges are not hard. The Inflammatory Ulcer depends upon an irritable state of the constitution, and presents few granulations, a raw 32 BOVINE PATHOLOGY. appearance, and ichorous or sanious pus. When the irri- tation is local, it gives rise to excess in size and extreme painfulness of granulations, while the surrounding parts are congested and cedematous—such is an Inflamed Uleer. Weak Ulcers have large, cedematous, pale, flabby granulations ; they occur on cedematous organs. Callous Ulcers are usually deep with pale base, pre- senting small, imperfectly formed granulations, and having an ichorous discharge of tissue débris. The borders of the ulcer are thickened, hard, and project considerably. A Fistula, or Sinus, often has this character. Fistule penetrate deeply into parts, and open at each extremity. Sinuses have only one opening to each; but we may have fistulee and sinuses which present all the characters of healthy ulcers except their shallowness. Specific Ulcers are such as occur in specific diseases. Sometimes these lesions are diagnostic, but often their special character may be proved only by the nature of the pus produced by them. A Cold Ulcer is surrounded by a purple ring of con- gested tissue, and is of a very painful character. It is very often specific, and results from marked deficiency in circulatory energy in the affected part. It occurs under a special form in those parts of old animals which are far from the centre of circulation. It is then termed “ Senile Ulcer,” and is characterised by a deficient tendency to repair with a liability to rapid spread by sloughing of tissue. Thus, several ulcers “run together,” producing a widespread breach of tissue. They are then said to be Confluent Ulcers, and this tendency to blending of ulcers is marked in several specific disorders. The Phagedenic Ulcer rapidly spreads by sloughing of masses of neighbouring tissue. A large foul surface with an ichorous discharge is thus left. This serves to draw our attention to molar death, which may result from in- flammation, and is termed Ganerenz, depending upon the processes which constitute sphacelus or mortification. When the supply of blood is cut off from an organ or any INTRODUCTION, 83 part of the body it dies, and chemical forces are enabled to bring about its decomposition. Sometimes the blood is not permitted entry into a part through obstruction of the arteries of supply; then dry gangrene may take place, which consists in the drying up of the tissues, their diminution in size, and complete loss of all vital pro- perties. The dry, mummified mass remains as a foreign body, perhaps becoming invested by a coating of lymph. This has been observed in the case of pleuro-pneumonic lung. When a part is the seat of moist gangrene, it be- comes very dark in colour, pits on pressure, swells in con- sequence of the liberation of gases by decomposition and their accumulation beneath the epidermis, which they raise in spots forming blebs. A sanious discharge with foctid odour takes place from the surface of the mass, which is sodden with a similar material, and has lost all sensation and other physiological processes, and is very cold. Moist gangrene is more frequent than the dry form, and depends on impeded return of blood. A _ part which has thus undergone mortification is removed by sloughing. Salutary inflammation sets in on the line of junction of the dead with the living parts, and here con- solidation by exudation takes place to prevent infiltration of gangrenous material into healthy parts. Suppuration of this consolidated layer occurs, and thus the dead mass is thrown off. Molar death of bony tissue is termed Necrosis, and the portion of removed material is a Srquzstrum. During this process of gangrene the con- stitutional powers are much diminished, the pulse being small and weak and frequent, and the strength rapidly failing. The animal has a wild, apprehensive look, and is very restless ; cold sweats bedew the skin, and there is a gangrenous odour. Sudden cessation of pain often announces this result of inflammation. The termination of the case will be favorable or otherwise, according as the strength of the body proves equal to removal of the slough or the reverse. Inold age senile gangrene may occur asa result of deficiency of vital energy, affecting especially those ‘parts most remote from the central organ of circulation. 3 34 BOVINE PATHOLOGY. Resolution is a termination of inflammation most to be desired ; it consists in the gradual resumption of healthy conditions of the diseased part. In it the products of cell proliferation are absorbed, lymphy deposits and serous effusions undergo the same fate, and the blocking up of the vessels which has resulted in stasis gives way, so that healthy circulation is resumed. When this process occurs very suddenly, as when only stasis and effusion of serum have to be overcome, a few hours suffices for resolution, which is then termed Drtitzscencz. Occasionally this is related to appearance of inflammation in some other organ, when it is termed Martastasis, a phenomenon which occurs very frequently in rheumatic affections. How this is brought about we are not in a position to say. Cases of false metastasis have been found to be due to direct con- tinuity of structure, and true alteration of the seat of an inflammation may be due to the ill-ascertained conditions of nerve continuity. There are various terms used to. indicate the forms assumed by inflammation as dependent on consitutional or local conditions : Specrric, when it depends upon the presence of special materies morbt. Traumatic, when it is due to local injury from without through mechanical, chemical, thermal, and other agen- cies. Iproraruic, when not attributable to any such cause. SrHenic, when occurring in a constitution with high vital energy, and tending to the throwing out of plastic lymph, which rapidly undergoes organisation, or to sup- puration. The pulse being full and strong, and the internal temperature high, and the nervous system in a state of high activity, these cases run their course in a short time. AsTHENIC, when tending to assume a low character with imperfect lymph deposits which do not circumscribe the accumulations of badly matured pus, which, therefore, tends to spread widely by infiltration into neighbouring parts. This leads to extensive destruction of tissue, and a depressed state of the constitution, the pulse being INTRODUCTION. 35 weak, quick, and often irregular, and the temperature being liable to marked variations. This depends upon a depraved condition of the blood in the majority of cases. Acuts Inriaumartion is of the sthenic type, running its course with well-marked symptoms, and passing rapidly either to resolution or to suppuration, ulceration, or gan- grene. In the curonic form both local and general sym- ptoms are slight ; the tendency is to firmness and organi- sation of deposits with permanency of effects, and the conditions which are set on foot by it are slow. Inflam- mation is considerably influenced in its course and effects by the tissue in which it is located; thus, we shall notice that mucous membranes thus affected tend to suppurate, fibrous tissues to undergo calcification, serous and synovial to exudation of lymph, cartilage to caries and ulceration, &c. ’ Conczstion is a form of diseased action, second, indeed, to inflammation in importance and complexity, but never- theless exercising an important influence upon pathology. Dr. Williams distinguishes between congestion and hyperemia, considering the former to differ from the latter in that retardation of movement of blood through the affected part has occurred. In both cases there is excess of blood in the part, but in hyperzmia the flow is rapid and the outfall as great as the income. Hyperzmia is, therefore, not disease ; it occurs in every organ or tissue which is in a state of activity. Congestion may be active, passive, or mechanical. Active Congestion is that accumulation of blood in a part which occurs when the income is great but the out- fall is small. It occurs as a result of irritation, precedes the inflammatory process, and often is confused with hyperemia. Passive Congestion results from a relaxed condition of the small arteries and the capillaries of a part depending upon deficiency of tone, so the flow of blood becomes slow, and the vessels distended. It may arise either from local or general disorder of the vessels, from imperfect 36 BOVINE PATHOLOGY. action of the heart, or from a depraved condition of the blood. Mechanical Congestion depends upon impediment to return of blood from a part in consequence of pressure on the veins ; it generally assumes the passive character. In active congestion there is swelling, pain, redness, and heat, with an exaltation rather than a perversion of func- tion, but practically it is extremely difficult to distinguish from inflammation upon which it verges. Passive con- gestion is indicated by swelling due to serous extra- vasation, coldness and deficient vitality of the part, which has a dark blue colour. The swelling is influenced by position of the patient, for it is caused by a watery fluid devoid of plastic elements. Such swellings may dis- appear very rapidly and occur in pendulous positions. Congestion terminates either in inflammation or resolu- tion, and may persist for a long time, giving rise to Exrravasations, either serous or sanguineous, or mixed (sero-sanguineous). Serous ExrravasaTIoN may occur either on a serous or mucous surface, or into intercellular spaces. It may be seen in the early stages of catarrh of various mucous membranes, and, mingling with mucus, constitutes the discharge of the early stages of inflammations of those structures. When serum is extravasated into a serous cavity as a result of congestion, it is a salutary relief to the diseased parts, and the liquid can be readily returned into the blood, for the serous cavities are only large dilatations of lymph-vessels. Intercellular collections of serum are similar in their pathological importance. Sometimes, however, accumu- lations of serous or sero-sanguineous fluid appear on the surface of the body as a result of injury ; the surrounding areolar tissue becomes condensed and retains the fluid. Incision into these “serous abscesses” is sometimes necessary. Sanguineous extravasation is known as HamorrHacs. It depends either upon a depraved state of the blood, or on a giving way of the walls of vessels. Not only in the latter case is unaltered blood displaced, but it is allowed INTRODUCTION. 8? that a migration of red corpuscles (diapedesis) as well as of white may occur from the vessels under certain circumstances. Hemorrhage is TRAUMATIC when due to injury from without, and ipioparHic when dependent on intrinsic causes. Traumatic haemorrhage may be due to injury of arteries, veins, heart, or capillaries, and will be treated more at length under the heading * Wounds.” Idiopathic blood-extravasation may be active or passive. Active Hemorrhage occurs in plethoric subjects, and is preceded by active congestion. It results from a giving way of the walls of capillary vessels, and the blood which thus escapes is considerable in quantity, of a bright colour, flows rapidly, and coagulates freely. Passive hemorrhage generally depends upon debility and a disordered state of the blood. It occurs in organs which have been weakened by disease, and is often a symptom of some value. The escape of blood tends to still further reduce the strengt' of the patient. In certain blood disorders we find extra- vasations of blood, either considerable infiltrations of areolar tissue (hemorrhagic infarctions), or circumscribed small patches of blood, petechta. Rupture of the wall of a vessel, fracture of bone, and other lesions of a like kind, are known in surgery as “ Sonutions or Continorty.” These give rise to disorder only when the continuity of structure is essential to due performance of function; thus, a solution of continuity of horn may be present and give rise to no inconvenience if the sensitive structures beneath be not exposed to injury, as from compression. Again, a simple incised wound, when the parts are brought and maintained in contact, may become obliterated by simple growth without the intervention of inflammation. In bones continuity is essential to render them firm bases of support. FRacruxzs, therefore, interfere with function, and must be carefully studied. The walls of blood-vessels are constantly subjected to pressure by the contained blood, when a solution of their continuity takes place, therefore, Hamorruace results. In the present state of pathology we must admit the 38 BOVINE PATHOLOGY. existence of certain FUNCTIONAL DISORDERS, on the under- standing that they will probably, with improvement of methods of research, be proved to be due to alteration of structure. The term “ Functional disease” is of value clinically, especially in relation to disorders of the nervous system and other parts, with the physiology of which we are not very well acquainted, but as our knowledge of physiology and its relation to structure advances, we trace such disorders to appreciable changes of struc- ture. Functional disease of the rumen occurs in some cases, and leads to accumulation of gas and food in that viscus. Probably the derangement is due to nervous disturbance, for such accumulation is found in many brain diseases. We must be understood, therefore, to imply a certain amount of ignorance when we speak of disorder of function. In conducting a post-mortem examination we must be as systematic and thorough as circumstances will allow, _ so that we shall be in a position to give evidence on each case to either legal or medical authorities. The note- book should be in constant use, and we must adopt an established routine, to be varied as little as possible with the exigencies of time, place, &c. Thus, the external evidences of disorder must first be noted, position, expres- sion and rigidity of the patient ; then the presence of dis- order of the skin and visible mucous membranes, any indi- cation of discharges or of injury, the age, sex, condition, and breed of the animal, also special circumstances of history. The carcase of the ox in the field must be supported by means of pitchforks so placed as to sustain the limbs like props. In the cow-house, or barn, or shed, the limbs of one side may be supported by ropes thrown over a beam. In opening the peritoneal sac by incisions through the abdominal walls the conditions of the peritoneum and the position and general appearance of the abdominal organs must be observed, also any abnormality of the contents of the peritoneal sac, which may be bloody, purulent, loaded with flocculi of lymph, contain food material, &. The stomachs, with the intestines, should then be removed, INTRODUCTION. 89 and thus the liver, kidneys, diaphragm, and genito-urinary organs are more or less exposed. The situation of each of these should be examined before removal, any abnormal relations and adhesions being carefully noted. To thoroughly examine the genito-urinary apparatus one of the hind limbs should be removed from the hip, and the symphysis of the os innominatum and the neck of one ilium cut through with the saw, and the portion of bone thus loosened removed. Next, the thoracic viscera should be subjected to scrutiny, the articulations between the sterno-costal cartilages and the true ribs having been divided, some of the anterior sterno-costal cartilages of false ribs may be cut through, and thus the sternum drawn away from its position and forwards. To do this the connections of the fore extremities with the trunk must be divided, and the skin reflected from the median inferior longitudinal line of the body. During this process dropsical collections or diseased conditions of the axillary lymphatic glands may be found. The pericardial and pleural sacs must then be examined for they are exposed, and their contents must be observed. The heart and lungs may be then removed en masse. Next, the diaphragm and liver may be separated together from the surrounding parts. After this the structures in the lower part of the neck must be separated from their surroundings and examined, but left in position until we have the structures of the fauces ready for removal with them. ‘This is accomplished either by dissection of the skin from the central line of the sub-maxillary space, and a deep incision on either side against the inner surface of the lower jaw, whereby the tongue is freed from its attachments, anteriorly and laterally, and can be drawn between the branches of the lower jaw, or by removal of the skin farther up the side of the face, and amputation of half of the inferior maxilla at the symphysis, and just below the condyle. The mouth, pharynx, posterior nares, and isthmus faucium may thus be examined, and the temporo-hyoid articulations being divided, the tongue, larynx, and pharynx removed with the trachea, esophagus, 40 BOVINE PATHOLOGY. &c. The head having been skinned and disarticulated at the occipital condyles, may be retained for examination of the brain, eye, nasal chambers, &c., secundum artem, The subsequent examination of solid organs, variations in size, form, and structure must be noted and deter- mined to be primary or secondary causes of death. The contents of hollow viscera must be retained and examined, and the capacity, form, and structure also placed on record. Finally, a scientific summary of post-mortem results, with conclusions deduced from them, should be drawn up after each organ or tissue exhibiting disease has been specially examined. Disease may assume various forms dependent upon its method of appearance and the manner in which it runs its course. Thus, acute disorders are characterised by short periods of attack and rapid morbid changes leading to death or to resolution in a few days, whereas chronic cases last for some time, changes occur more slowly and lead to greater permanent alteration of structure. Such attacks as are active in their phases, but chronic in their effects, are termed Subacute. Different diseases generally affect one or other of these characters. Certain blood diseases are very liable to assume the chronic form, rheumatism, for instance, while inflammations of important viscera, as the lungs, heart, &c., are generally acute. When a number of animals of the same species become simultaneously affected with a disease which does not seem to be confined to any special locality the outbreak is said to be Epizooric, but if animals of various species suffer from the disorder it is termed Panzoortc. Enzoorics are those diseases which affect a number of animals in a circumscribed locality. Thus, eczema epizootica is a panzootic, pleuro-pneumonia zymotica is an epizootic, and anthrax generally manifests itself in enzootic outbreaks. The term Srorantc is applied to those disorders which do not affect a number of animals simultaneously, but now and then an individual becomes attacked, while a number of others subjected to like conditions escape unharmed. Most non-specific disorders assume the sporadic character, INTRODUCTION. 41 Having determined the nature of the attack under which an animal is labouring, and by the various methods of “inquiry above noted, in so far as they are applicable to the special case, having arrived at a conclusion as to the part disordered, and the extent to which it has undergone pathological changes, and to which its altered conditions affect surrounding parts, the practitioner must next determine the method of treatment to be adopted and rigidly enforced with a view to restoration of health, or to a condition of fitness for special duties according to the nature of the patient. It has been truly remarked that in many cases a veterinary surgeon has not the oppor- tunity to carry his medicinal skill to its full extent since his patients are almost always viewed as representing so much capital, and not as being in a position to claim moral protection for life so long as it exists. Again, in the majority of cases the veterinary surgeon must thoroughly cure his patient, and may find a “ patched up ” case which would bring his medical confrére much credit, is apt to prove even prejudicial to him. Such being the case, it can hardly be a matter of wonder that the study of the treatment of such animals as our bovine patients has not been pursued with such energy as certain other branches of therapeutics. The animal if slaughtered at once will prove useful for food, if kept alive will probably have its system impregnated with medicinal agents, and at the same time will rapidly decline from ‘‘ market con- dition.” The veterinary surgeon’s bill and the keep of the animal until it is again fit for its special duties will mount up very considerably, so the owner is too often tempted to send the patient immediately to the butcher. Promptness is most essential, then, in the treatment of our patients, both in prognosis and in administration of remedies. In all cases we must remember the grand rule “remove the cause and the effect will cease,” and must not only remove the immediate cause, but any other influences which are tending to bring about increase of the disorder. We must thoroughly trace out the value of each pathological condition in relation to other morbid 42 BOVINE PATHOLOGY. states, and the primary disease must in all cases determine the course of our therapeutical efforts. All secondary diseases, symptoms of which show that they are liable to destroy the patient, must also receive attention ; thus, in a case of indigestion we often require to prevent death from suffocation when distension of the rumen with gas impedes movements of the diaphragm, evacuation of the gas is then urgent and must be adopted asa palliative measure, together with the curative means directed to reduction of the indigestion. Curative means may be either medicinal or surgical. Medicinal agents of various kinds have been found to have different effects upon the animal system since they increase, retard, or prevent natural processes. A judicious selection of these agents may be made to assist nature in her attempts to restore healthy conditions; in all cases the educated prac- titioner must apply his knowledge of the action of special medicaments and of the methods which nature adopts as reparative. Thus, with a wound of a sluggish character, he will endeavour to promote salutary inflammation by means of digestives, and in a case of hemorrhage, he will endeavour to coagulate the fibrine of the blood and so plug up the orifice of escape. Treatment must be of no definite and fixed character, nostrums and recipes occupy too prominent a position in works on cattle diseases ; the educated practitioner alone should treat the case, and he will be able to vary the doses and agents administered according to the many and ever variable phases of diseased action. Human medicine has been facetiously termed “the art of amusing the patient while nature cures the disease.”’ All medicinal treatment consists in a state of constant vigilance and free supply of aid whenever the vis medicatrix nature requires us to assist her in restoring health equilibrium. Surgical Treatment comprises all operations performed upon the various parts of the body with a view to restoring the natural condition of the constitution or a satisfactory state of health. Many refinements which have been adopted in human surgery and so materially allevi- INTRODUCTION. 48 ate suffering and prolong life, have not been able hitherto to find a place in veterinary surgery. For want of co-operation on the part of the patient and his slight pecuniary value if imperfectly restored, and the expense of keep, prove sad opponents of our advancement in this respect. Thus the medical and surgical branches of professional work have not been artificially delegated to distinct. sections of practitioners, and as they depend on the same laws of disease, and are at every phase in close interunion, we have not deemed it right to separate surgery from medicine in the work before us. Surgical treatment comprises operations, the use of appliances, and dressings of various kinds. Orzrations may be performed with special instruments or by manipulatory methods; they have for their aim either removal of the cause of disorder as in cesophagotomy, or palliation of its effects, as opening the trachea in a case of laryngeal obstruction. Again, they may have a pre- ventive effect, as in removal of ® tumour which by its spread tends to involve important organs, and ovariotomy in an animal with some mechanical impediment, to expul- sion of afcetus, Operative surgical skill may, to a certain extent, be acquired in the dissecting-room by the study of topographical or regional anatomy, but can only be per- fected by operations on the living subject, preferably in the course of general practice; though some educational authorities consider that the pain inflicted on a few animals during a course of operative vivisectional surgery, will be amply atoned for by subsequent more skilful execution of professional duties. In the performance of any operation the practitioner must have determined beforehand the most favorable methods for the particular case, the com- plications liable to arise, and the measures of after treat-~ ment which will be necessary if everything succeeds according to his expectations. It is in the occurrence of complications that the skill of the operator is best tested ; coolness, promptness in emergency, and neglect of sur- roundings, are valuable qualities under these circumstances. With large patients special means of restraint during all 44 BOVINE PATHOLOGY. major operations have to be resorted to by the veterinary surgeon. The animal requires to be cast or otherwise to be disarmed of defensive powers and ability to escape. AnzstHetics have not been hitherto used much in veterinary surgery. They are not so frequently required as in human surgery because major operations on animals are less frequent, and also because the amount of nervous wear and tear in the lower animals is not so great as in man, with his extremely elaborate and delicate nervous mechanism. The pain of anticipation, also, in animals, is reduced to a minimum. CxHLoRororM requires to be administered in very large quantity to large herbivores, and seems to so thoroughly impregnate the blood as to interfere with subsequent healing processes and to give rise to serious complications. This agent proves more expensive than the owner of the patient generally likes, and the preliminary stage of excitement produced by it induces severe struggling and reduction of the strength of the patient. Local anesthesia as induced by Dr. Richardson’s spray diffuser, has been used for certain veterinary operations ; cold water is sometimes continuously applied to produce this effect, and cocaine has been utilized in this way for Bovine surgery. Fra. 5.—Spray diffuser for anmsthetics or disinfectants, The preliminary treatment of a patient must be such as will induce as vigorous a state of the constitution as is compatible with the circumstances. Food of good quality and wholesome, a free supply of air, and exercise, should INTRODUCTION. 45 be adopted when possible. Operations should not be per- formed when certain blood diseases are present, and organic disease of various organs, together with the special condi- tions of the patient, should be most carefully considered. Professor Williams is careful to caution us lest we ope- rate with dirty instruments or hands or near a dissecting room. The operation should be performed in a place where there is lots of room, light, and quietude. The subject should be placed in position by skilled assistants, and the necessary instruments and appliances should be clean, in order, and placed under the charge of a special assistant. Thoroughness, cleanliness, and judgment should be the fea- tures ofalloperations. Emergencies asthey arise must be met and counteracted. Heemorrhage, protrusion of viscera, and collapse of the patient, are some of the most formidable. Cot.apse consists in sudden interference with the heart’s action, the result of nervous shock. The patient ceases to struggle, and loses all voluntary power, the limbs are relaxed, the pulse scarcely perceptible and extremely irregular; sighing, pallor of visible mucous membranes, and coldness of the body are present in most cases. In this state of affairs a free supply of fresh air must be secured, and sometimes artificial respiration resorted to. Stimulants must be administered and frictions applied to the extremities and general surface. Extreme quiet and stimulant tonics must constitute the after-treatment. When death occurs from this cause, the blood is found diminished in consistency and occupying all the cavities of the heart, the right especially being engorged. Tn all cases after a serious operation the patient should be kept in a well-ventilated house, and supplied with good and not over-nutritious diet, the necessity for stimulant and tonic agents being estimated in accordance with the case. The various forms of appliances and dressings will re- quire special notice. An important rule to be observed in operative surgery is to preserve every portion of structure which can become useful, while removing all diseased parts with an unsparing hand. This is the grand doctrine of 7 EP) “ Conservative Surgery. 46 BOVINE PATHOLOGY. Finally, we must impress upon our minds the extreme value of Nursine and PREeveNnTION. Nursing consists in attention to minor details which are conducive to the comfort of the patient. Supply of tempting and palatable food, and water or other drinks, as suited to the state of the patient ; free supply of fresh air of an agreeable temperature, prompt removal of ejecta, and the supply of a good clean bed of straw, clothing properly and with judgment, administration of medicines in the gentlest and most effectual manner, and application of dressings of various kinds, also constitute the duties of the nurse. When it is remembered that very frequently these simple matters prove more valuable than more active treatment, the necessity for good nursing in all cases will be evident. PREVENTION or PROPHYLAXIS is a most important question. We have seen that conditions are rather unfavorable to curative treatment, but prevention is correspondingly valuable. Veterinary surgeons are called in to prevent disorders of any kind among a herd of cattle, or to adopt special prophylactic means against such a disorder as anthrax. In each case he must carefully adopt hygienic measures with a view to avoidance of predisposing causes. When exciting influences occur they will then be less able to produce marked effects. The quality and quantity of the food must be duly regulated ; the purity and tempera- ture of the air and the sanitary conditions of stalls, houses, &c., as well as the general treatment of the beast, must be adapted to the object for which they have been kept Such individual predispositions as result from age, con- formation, breed, and temperament, must as much as possible be obviated ; and, lastly, all exciting causes, such as standing in draughts and sudden transitions from heat to cold must be guarded against. There can be no doubt that by such means latent tendency to tubercle and other similar affections can be restrained for a considerable time. The effect of disease of parents may be manifest at birth when it is termed Concenrrat, or it may remain 1 J . ] . » Neceasity for lnprovement ia Farm Hygiode'” (pabiiued wee evetadeee Journal’ and ‘ Veterinarian’ for 1886) ought to be studied by both practi- tioner and student. INTRODUCTION. 47 in a latent state until the young animal has attained a — definite age corresponding often with that in which it first appeared in the parent. For the prevention of out- breaks of special disorders various means are adopted. Inocunation depends for its value upon the fact that some diseases do not occur twice in the same subject, and when artificially induced have a mild character. Vaccination consists in securing immunity from a severe disorder by bringing on an attack of a closely allied but very mild disease. SprcraL BREEDING consists in the crossing of animals of a breed predisposed to a disorder with animals of a breed manifesting no such tendency, as in crossing shorthorns with less carefully bred animals. SPECIAL LEGISLATIVE MEASURES, with which we shall after- wards have to deal, are necessary to check contagious disorders. The treatment of inflammation is complicated in accord- ance with the complex conditions of that pathological state, and the effects of these processes. We must remember that inflammation is in very many cases salutary and that it must therefore be encouraged under the following circumstances ; when reparative, constructive, or usefully destructive. Reparative inflammation is the means by which injuries are repaired, and when a con- siderable amount of new tissue has to be produced, as in filling up’ an abscess cavity, constructive inflammation causes granulative repair. In the removal of foreign bodies, whether introduced from without or resulting from death of a part, as in sloughing, inflammation is usefully des- tructive. Inflammation under these circumstances must be carefully watched, and either promoted or controlled as occasion may require. If the process becomes sluggish, as in indolent ulcers, on account of deficiency either of local or constitutional energy, stimulants must be applied or administered ; while if the local changes are intensely acute and give rise to a high state of fever sedative means must be adopted locally, and general sedatives and antiphlogistics be used. At the same time the 48 BOVINE PATHOLOGY. cause of excess or deficiency must be sought for and removed. In salutary destructive changes where a foreign body becomes the centre of an abscess, whenever necessary the tendency of the abscess to pass in the direction of least pressure must be directed by relaxing superficial parts by moisture and warmth, also any impe- diment to such progress towards the surface, as layers of fascia, must be overcome by operation. Our anatomical knowledge will guide us in this matter. Local energy must be promoted in cases of removal of gangrenous parts by sloughing, and when the general or local powers begin to flag they must be assisted by surgical removal of the altered mass. The circumstances of each case will suggest to the practitioner the proper time for operation, and when there is inability to produce a “ line of demar- cation,”’? removal must be made where the tissues retain vital energy sufficient for repair. When it is necessary to treat inflammation of a non-salutary character the original cause of the disorder must be first removed. Thus, a foreign body in the muscular structures of a part, resting - op the conjunctiva, or situated in a passage too small to accommodate it under ordinary circumstances, if not removed artificially will be thrown off if possible by exacting processes of nature, or death will result from the attempt. Occasionally a coating of lymph will be thrown out over a foreign body, and thus its irritating characters obviated. Next, ail causes which tend to produce similar inflammation must be removed, for they simply aggravate the casein hand. Thus, in inflammation of the peritoneum quiescence of the bowels is to be sought, for active peris- talsis, suchas results from cathartics, causes friction between the inflamed surfaces. As activity predisposes to disorder, both directly and by influencing blood supply, we must secure Rust whenever possible ; thus we keep the animal in a dark place in cases of ophthalmia, and endeavour to promote the action of other excretory organs in cases of inflammation of the kidneys, to relieve the diseased glands, . There is a natural tendency to this which we must eudeavour to promote. The substitution of the action INTRODUCTION. 49 of one excretory organ for that of another is vicarious activity. Agents which, when administered internally, counteract inflammation, are termed antiphlogistics. Many of them act by promoting vicarious secretion, whereby the blood is purified; also in doing so they act as derivatives. There is a marked determination of blood towards a part suffering from inflammation, and a corre- spondingly diminished supply to other parts of the body. Our efforts must be directed to the diffusion of nervous energy which controls vaso-motor activity, so we resort to general stimulants, clothing, hand rubbing of limbs, and stimulating applications to the surface. It has been long recognised that when blisters applied to the surface of the body during internal acute inflammation act freely it is a favorable sign. We must look upon it as a proof of diffusion of nervous energy and blood which previously had been accumulated in. the affected part. Derivatives assist in the process of diffusion. The excess of blood is removed from the zone of congestion and simple hyperzemia around the part where stasis has occurred, and thus the disease limited in its extent. The same effect results from certain modifications in posture, and from bloodletting. Certain agents have been extolled as especially efficacious in cases of severe inflammation, either by producing changes in the blood or by their action upon the heart. Mercury, as calomel, acts on numerous secretory organs, and is correspondingly valuable as a means of purifica- tion of blood which is over-loaded with inflammatory débris; also it is considered to check or prevent plastic deposit. It is a debilitating agent of a very powerful kind, and so is often contra-indicated. _ PorassIO-TARTRATE OF ANTIMONY is considered valuable in reducing the heart’s action as does bleeding, but having the advantage of it being permissible to administer it several consecutive times. Diarrauis also controls the heart’s action, but it is cumu- lative, and thus requires very careful watching. It pro- duces intermittency of the heart. Opium is valuable “in various ways; by quieting the a 50 BOVINE PATHOLOGY. nerves, by sustaining the faltering action of the heart, by keeping the inflamed parts at rest’ (Watson). In nursing a patient suffering from severe inflammation we must select such food as is very easy of digestion, and therefore not likely to aggravate the disordered condition which the stomach shares with other organs of the body in such cases. The appetite of the patient must be tempted, for it is generally difficult to make him take anything which will assist in husbanding the strength against the emergencies of the attack. Some practitioners rely almost wholly on stimulants in the treatment of in- flammation; these, they urge, foster the strength, and hasten the local changes to a favorable issue, while they prevent all those unsatisfactory effects, such as ulceration and gangrene, of deficient local power which are apt to result from the depletory system of treatment; they also prevent the attack from lapsing into a chronic character. There certainly is much feasibility in this line of argu- ment, and the benefit of the system is proved by the un- doubted fact that under it cases of true hydrothorax less often result from pleurisy. But we must exercise judgment and discriminate when we can afford to run the risk of plastic results of an acute attack, and when haste is less essential than thorough ultimate recovery. In all cases where vital organs are inflamed stimulating treatment is likely to be of value. With regard to local conditions, too, sometimes stimulation is beneficial. This is well shown in many cases of so-called counter-irritation, as in application of vesicants to the sides in cases of pleuritis. Undoubtedly many cases of supposed inflammation, are at first simply congestion, and nowhere does this more often occur than in the pleura; the stimulus arouses the activity of the congested blood-vessels, and enables them to expel their contents, and thus immediate relief follows. Again, undoubtedly deficient nervous energy in a part is a potent cause of inflammation; stimulation removes this cause. It is even possible that when stasis has occurred a sti- mulus may so strengthen the blood-current as to enable it to break down the obstruction, and so alter the local INTRODUCTION. 51 states of nutrition as to give no tendency to renew it. But while admitting this mode of action of external stimulants, we cannot refuse to admit the derivative effect of COUNTER-IRRITANTS. Recent researches on the vaso-motor system have proved how powerful an effect a stimulus may have in altering blood-distribution. These researches, though by no means complete, are favorable to the view that a deep-seated inflammation may be relieved by originating a similar process in superficial tissues. Setons, blisters, cauteries, and rubefacients are means to this end. Coup, when applied locally in a continuous manner for a long time, will, in such cases as open joints and similar pathological states, enable repair to occur with a minimum of inflammation, for such, if it set in to a marked degree, would cause high fever on account of the unyielding nature of surrounding parts. Also under this treatment the in- flammation is not so liable to involve the joint surfaces. This continuous application numbs the parts, and so lessens pain; but some say that ultimately the white muscular fibre of the arteries relaxes, and passive congestion occurs. However this may be, its practical value in joint diseases has been proved. Hear with Moisture relaxes parts, and so eases pain, it also tends to promote suppuration. It must be used, therefore, to assist the maturation of abscesses, but should be avoided whenever suppuration would be prejudicial. In the earliest stages of inflammation resolution may be brought about by warmth mechanically relaxing the vessels in which stasis has occurred, and thus readmitting the current of blood, or the same effect may be the result -of extravasation. Loca Szpatives, as Goulard’s solution of the subacetate of lead, check the spread of inflammation by lessening the passive congestion around the seat of stasis; they are very useful in cases of ophthalmia, contusions, &c. Loca Bioop-LETtine must never be brought about by incisions in the inflamed part, but rather in the proximity. It seems to temporarily relieve congestion and hyperemia, 52 BOVINE PATHOLOGY. but the effect is evanescent. Occasionally free scarifica- tions allow the escape of excessive extravasated material, which, by pressure, tends to interfere with favorable pro- gress towards resolution, For the removal of effused material pressureand stimulation have been found beneficial. The effects of pressure are very gradual, and some mechani- cal applianceisnecessary; the moreconvenient planof stima- lation is, therefore, generally adopted, compounds of iodine, especially the biniodide of mercury, being most useful. The friction in application also tends to promote absorption. When ulceration is present the treatment must be regulated according to the condition of the sores. Often tonics and stimulants must be administered internally. Indolent ulcers require local stimulation; callous, the application of caustics, whereby a fresh granulative surface will be exposed ; inflamed, local sedatives; inflammatory and specific, attention to constitutional conditions ; phage- denic, powerful caustics, followed by poultices. When Surrvurarion has occurred, free exit must be given to the pus by means of a depending orifice, but the abscess must not be opened until fully matured. Purulent infil- trations should be relieved byincision. The system must be well supported by nourishing food and stimulant tonics in the meanwhile, and the animal be clothed carefully, for suppuration is an exhausting process, and causes febrile symptoms, rigors, debility, and fulness and rapidity of the pulse. Tonics will be favorable to the constructive pro- cesses by which the abscess cavity will be filled up; locally, carbolic dressings are most useful. Mortification necessitates support of the strength of. the patient, for not only is the system severely taxed in throwing off the slough, but also gangrenous fluids tend to enter the circulating current, and give rise to an asthenic character of subsequent changes. Stimulants and tonics require to be administered freely internally, while poul- tices such as Cataplasma Calcis Chlor., or Catap. Fermenti, promote the separation of the slough. We have already indicated that surgical removal of the diseased part is oftea necessary. INTRODUCTION. 53 It remains only for us here to state that febrile com- plications of inflammation will be subsequently noticed, and that inflammation is sometimes induced as a prophy- lactic means, as when a seton is inserted in the dewlap of young cattle as a preventive against “black quarter.” ConeEstion requires treatment directed to the removal of causes, such as relaxation of arteries or impediment to return of blood through veins. Often a local stimulant will remove any tendency to stagnation, while astringents, such as cold water, will cause tonic contraction of the previously passively-relaxed vessels. When the conges- tion is due to weakness of constitution, tonics must be prescribed. Often it is necessary to palliate the accumu- lation of blood by scarifications, phlebotomy, or applica- tion of equable pressure to the part. An elevated posture will prove beneficial. Moisture with warmth may lead to removal of congestion by causing the vessels to relieve themselves by serous effusion. Haworruacs, when traumatic, must be treated as here- after described. When due to blood disease, and occur- ring as petechie and hemorrhagic infarctions, they must be deemed of minor importance as secondary to the general disorder of the blood. The other form of passive hemorrhage, that due to debility, must be treated by strengthening the patient; and in active hemorrhage we must reduce plethora and tendency to congestions by less food and more exercise, and also laxative and diuretic agents. Local astringent applications, as cold water, act as styptics, restraining hemorrhage. Certain medicinal substances, when administered internally, are considered heemostatic, as oleum terebinthineg. Drorsy will disappear with the congestive or inflam- matory state from which it originated. The process may be promoted by stimulating the water excreting organs, kidneys, and skin; also such agents as lessen blood pressure promote absorption; digitalis is one of the best. If the supply of fluid for drinking purposes be limited, effused fluids will be taken up to maintain the due liquidity of the blood. Iodine and its compounds are 54 BOVINE PATHOLOGY. supposed to assist the process of absorption in these cases. When absorption is prevented by lympby deposits on the walls of a sac, or when the fluid has collected in such quantity as to cause extreme tension, paracentesis (or tapping) must be resorted to. Injection of a stimulating agent may close a serous abscess by lymph exudation. This is, of course, inadmissible in dropsies of serous cavities. Senile dropsy is generally incurable. Section 2. The ox, Bos Taurus, is a ruminating, hoofed mammal, and presents certain leading anatomical and physiological characteristics which leave their impress upon his patho- logical conditions. Thus the alimentary system is remark- ably well developed, constituting a considerable propor- tion of the total weight of the body. It is largely composed of stomachs, which fill the greater part of the abdomen and consist mainly of three compartments, modified forms of the inferior extremity of the cesophagus, adapted for pur- poses of rumination. The fibres of the tubular portion of the cesophagus are arranged in such a manner as to readily permit either upward or downward passage of the food, and the organs of mastication and salivation are specially adapted for prolonged action. As in other herbivorous mammals, the molar teeth are large grinding organs, which, by the size of the fangs firmly implanting them in the jaw, necessitate a large condition of the face in comparison with the cranium ; and by their weight so increase that of the head that the neck is short and presents superiorly a highly developed ligamentum nuchx.. The weight of the skull is also in- creased by offensive organs, the horns, developed from the fontal bones at the superior prominence of the skull. But the weight of these is lessened by the fact that into them extend prolongations of those large facial sinuses which contain rarefied air, and buoy up the unsupported skulls of most mammals, as the air sinuses in the bones of birds also buoy up their bodies in adapting them for rising INTRODUCTION. : 55 in the air during flight. As in other ruminants incisors are deficient in the upper jaw, being there replaced by a dental “pad, and in the inferior maxilla the canines assume the figure of incisors and form part of a continuous series of eight. The anterior extremities of the nasal and oral chambers are connected together by a duct of Stenson, leading to the organ of Jacobson, an accessory olfactory appa- ratus, in all probability closely connected with the mouth that the sense of smell may exercise more direct control against ingestion of poisonous herbs. The upper lip and the anterior nares are occupied by the muffle, a fibrous organ covered with a delicate but firm membrane devoid of hair, but constantly, in health, secreting a dewy moisture, and kept clean by the tongue, which latter organ is deve- loped to aremarkable extent for prehensile purposes. The. eyes are prominent and rather far back as in other herbi- vores, whereby extensive range of vision enables the animal to view an enemy afar and not be disturbed suddenly during the prolonged period of rumination. This act is per- formed by the animal preferably in the recumbent posi- tion. The rumen when full presses against the diaphragm, and the thorax, under any circumstances, is not remarkable for extent, but has special provisions whereby it may in- crease in transverse diameter when the animal is lying down, Besides the shortness of the thorax of the ox and other ruminants as compared with that of the horse and his allies, the lungs are more largely composed of areolar tissue, the calibre of the trachea is less, and the anterior nares are smaller and less mobile, and devoid of that remarkable complexity of formation which assists in adapting the horse for rapid movement over the earth. Altogether the respiratory system is less developed than in the horse. In accordance with this the circulatory system is less developed, the arteries being small and the heart generally more frequent but less powerful in its action, so that the pulse has a somewhat soft beat. The blood does not ex- hibit that tendency to the formation of- the buffy coat 56 BOVINE PATHOLOGY. which that of the horse does under normal conditions, though the corpuscles are about equal in size. The nervous system has a rather small cerebrum, due especially to deficiency in size of the anterior parts of the hemispheres; these also are remarkably short in the ox. The spinal cord is fairly developed, and the ganglionic system large and energetic. The organs of the senses are all well developed, the skin is thick and somewhat loosely applied, and covered with a dense coating of hair; the thermogenic functions are active, hence the internal tem- perature is high. This we may associate with smallness and insensibility of the organs of exit of heat as compared with those of production. The other excretory organs, kidneys and liver, are large and active; the urine of the ox differing in some marked chemical and physical char- acters from that of the horse. The muscular system is less developed for functional purposes than that of the horse, and is less compact. The basement structures of the limbs are less adapted to secure sharpness and precision in movements, and termi- nate inferiorly in division, which produces the characteristic cloven condition of the hoof in ruminants, while the limbs of the ox are capable of more varied mobility than those of the horse, of which the forward kick is a rather forcible illustration. In each case these organs are used simply for purposes of progression, the ox therefore is devoid of ossific union of the fore extremity with the trunk, the clavicle being absent and the scapula large. The generative system is largely developed both in male and female. Sexual desires are urgent in the male, and he is specially endowed with strength and weapons suitable to enable him to maintain supremacy against intruders into the herd of which he is lord and master. A struggle for existence among the males determines at once the numerical excess of females and the continued improvement of the race. The female is prolific, frequently producing twins, with a period of gestation shorter than that of the mare. The mammary gland is largely developed and placed in the hypogastrium, INTRODUCTION, 57 In a state of nature the ox is gregarious, the females much predominating in numbers over the males. Inhabits prairies and other wide expanses of pasture land, spends his time partly in grazing and considerably in ruminating. Migrates frequently to fresh pasture land or flies rapidly with considerable energy from a foe. When attacked, defends himself with his horns and by trampling the foe under foot, sometimes also by kicking. Under domestication these conditions are much wigdl fied.. The range becomes limited to meadows and straw yards, or to the extreme of stall life, thus the fat produc- ing powers are increased, leading to either general fatness for feeding purposes or to increase in lacteal secretion to a most extraordinary degree. Warmth, such as results from shelter,and diminished supply of oxygen due to con- finement, operate in the same direction, and tend to dimimish vital energy while encouraging fat production. Limited range also lessens the activity and compactness of the muscular system, the “wiry” organism of the wild animal becomes altered into the “soft” state of the domesticated. There is no necessity for frequent migra- tion nor flight when they are protected by man, and the prevention of combats between males tends to interfere with the inherent energy of the race, and probably to generate a more docile offspring. Increased supply of more nutritious food, obtained without the necessity of traversing large tracts of country, and without the dis- -turbing influence of constant dread, causes actual increase in the size of the race. Artificial conditions to which the ox is subjected are such as tend to diminish the circulatory, respiratory, and cerebro-spinal sensory organs, to lessen acuteness of smell, taste, sight, and probably hearing, and also the secretory activity of the skin. On the contrary, the alimentary and generative systems (with, as a result, the ganglionic centres) are increased in activity in adaptation to our requirements. In the working ox the conditions of life are not so profoundly altered; he spends his days in the open air 58 BOVINE PATHOLOGY. utilising his locomotory system, and not indulging in either excess of alimentary or reproductive pleasures. He is hardy, but gives us examples of diseases of the locomotor system as also of the cloven hoof. Such marked subjection to the uses of man has led to two results; increase in varieties of the ox and increased liability to disease. As varieties differ from the original stock so in direct proportion do they become liable to disease, and when by culture we generate remarkable activity of an organ we render it correspondingly predisposed to disorder. In the production of a breed with special qualities there is a transmission of hereditary tendency to special pecu- liarities of structure and to activity of function, conditions predisposing to disease, and these predispositions are very marked as a result of “breeding in and in,” which pre- vents the counteraction of family tendency to some special degeneration by the introduction of new blood. Excessive development of one part of the body tends to cause a want of reciprocity of different parts of the body, to the preju- dice of the whole; only by very gradual development can modifications of species occur; nature shows us this, for variation under domestication tends to disease. The mere fact of breeding from near relatives is not prejudicial, if both be in a state of thorough health. - Gregariousness is not favorable to individual peculiari- ties, nevertheless, when epizootic disorders occur certain individuals will exhibit immunity under extreme conditions of exposure ; this seriously complicates experiments on the transmission of these disorders. A similar immunity from the effects of altered conditions may be noted after the ingestion of medicinal or toxic agents; some individuals require immense doses, while others become seriously influenced by small quantities. The latter con- dition is termed intolerance ; the former, tolerance, may be due to frequent administration of the same agent when it is of a non-cumulative character. Immunity in certain blood diseases is secured often by an attack either of the same or of a closely allied disorder, Diet acts as a predisposing cause of disease either by INTRODUCTION. 59 its quality, quantity, or mode of preparation. A very rich diet predisposes to anthrax and inflammatory disorders, a poor diet to anzmia and dropsies. Food materials may be in themselves prejudicial either by medicinal or poison- ous constituents. Mouldy fodder serves to illustrate this, also the various cases of poisoning by oil cake. Excess of food either causes excessive distension of the stomach as in plenalvia, or, when in small quantities fre- quently administered, gives rise to plethora. Deficiency of food gives rise to debility and anamia. When not enough food at a time is given to an ox he is unable to ruminate, thus indigestion is produced. The familiar instance of choking from an uncut swede is an example of ill effects from improperly prepared foodstuff. Diet unadapted to the special uses for which an animal is kept will frequently cause disappointment to the owner and require correction by the veterinary surgeon consulted about the case. An extreme instance of this may be seen in pregnant animals, for the nature of the diet will affect the well being of the foetus in utero. Anemic conditions of the mother will give rise to dropsy of the foetus and its membranes and perhaps to its death, while not unfrequently an ergotised condition of pasture grass is the cause of abortion. Pregnancy in itself alters the nutritive equilibrium of parts, and hence predisposes to disease, especially of the generative organs; it produces important though tem- porary systemic changes. ‘The pulse beats more rapidly, the amount of carbonic anhydride excreted from the lungs is altered, the constituents of certain excretions, especially the urine, are modified, the appetite often becomes depraved, and the state of the nervous system different from ordi- nary. These changes culminate in the special phenomena of parturition and lactation, and with decline of the latter diminishes the predisposition to disease from pregnancy. The conditions of surrounding air may predispose to disease. Many specific disorders originate through vola- tile contagions conveyed through the air and taken up through the respiratory mucous membrane ; this is termed 60 BOVINE PATHOLOGY Inrgcrion. Again, the air has an important influence on respiration and cutaneous exhalations. When loaded with deleterious gases it may act as a poison, but if these be present only in small quantities it may simply produce local disorder. Variations in the surrounding air consist principally in moisture, temperature, or purity. When moisture is deficient, but the air warm, the skin acts readily but the muscular system is relaxed, hence the system is predisposed to herniw. Tetanus is prevalent in countries with such a prevailing climate as this, and diseases become acute. Warmth, with moisture, while determining blood to the skin, lessens the escape of moisture from the surface and from the lungs; thus a sluggish lymphatic condition is induced, and the animal is predisposed to dropsical effusions and low fevers. These conditions are specially favorable to the growth and multiplication of vegetable organisms, fungi, such as give rise to anthracoid disorders and intermittent fevers. Cold, with dryness, produces just the reverse effects, and gives a very low rate of mortality. It is remarked that the first touch of frost checks the ravages of an epi- zootic. These conditions tend to slowness and stunted growth, but produce hardihood, and are favorable to the healing of wounds without the occurrence of septic accidents. Cold with moisture, tends to a lowering of vital energy, and an accumulation of impurities in the system due to defective excretion by the lungs and skin, diseases tend to an asthenic type, internal congestions frequently occur, and rheumatismal diseases are prevalent and severe. But where currents of air give rise to draughts they are active agents in production of disorder, they disturb the nervous system and originate inflammation in that organ which is most predisposed to disease. While warmth promotes fattening and the production of milk, it must not be procured at the expense of venti- lation and drainage. Unless fresh air is admitted, and foul air escapes, and ejecta are not allowed to accumulate, the air in the cowhouse will become overloaded with impurities which predispose to disease, will tend to make INTRODUCTION. 61 epizootics and other specific disorders of a highly destruc- tive character, will induce any disease which occurs to assume a low type. The drinking water supplied to an animal may be so impure as to originate or communicate disease. Besides the conditions already mentioned, age, sex, and conformation determine individual liability to disease. Young animals respire quickly, have a quick pulse, and high internal temperature, they are particularly liable to diseases of growth, to acute inflammations, and to catarrhal affections of the alimentary and respiratory tracts, also their constitutional energy is hardly able to check and counteract the ravages of entozoa. In adult animals the tendency is to certain disorders resulting from diet, also to diseases of the generative system. In old animals we find the effects of deficient energy of the heart and degeneracy of blood-vessels ; hence metastatic congestions, senile gangrene, and heart disorders occur especially in them. Male animals are most liable to acute disorders, _as being endued with higher vital energy than females. Castration materially modifies constitutional conditions, and secures immunity from such acute disorders of the generative organs as occur in the entire animal, facilitates fattening, and lessens lability to injury. It causes the disorder known as pelvic hernia or “ gut-tie.”” Females run the risks of parturition and lactation, their respira- tory, circulatory, and nervous functions are generally less active than those of the male. Conformation and the uses to which the animal has been put have marked effects as predisposing causes; thus, the shortness of the neck of the ox accounts for his frequent attacks of apoplexy, and too free exercise of generative powers will bring about atrophy of the bull’s testes. Previous disease of an organ predisposes it to renewal of an attack. Sometimes only imperfect repair occurs, and the partially formed tissue is liable to again become the seat of morbid changes, even without the action of any appreciable excitant. Recurrent abscesses are of this nature, as also certain forms of dysentery. Exciting causes are varied, . such as exposure to currents of cold air, sudden transition 62 BOVINE PATHOLOGY. from cold to heat, mechanical and chemical irritants. They will be specified under the heading of each disease. The general symptoms manifested by cattle suffering from acute disorders are dulness and separation from the rest of the herd, unwillingness to move, a “ hide bound” or “staring” condition of the coat (cutis anserina). The animals do not lick themselves or one another, nor stretch properly on rising; dryness of mufile, failure or deficiency of the appetite, and cessation of rumination. In the milch cow the lacteal secretion is diminished or suppressed. Frequently when these are observed examination by the experienced will detect fever and even local disorder, but generally we have only the history of the case to determine any efforts against special contingencies. Nursing must here be relied upon. The patient must be housed ina moderately warm, well-ventilated place, frictions applied to the surface, and laxative, easily digestible matter given as food; change of diet being particularly beneficial, but the appetite must be tempted, not forced. A diffusible stimulant will be useful under these circumstances, it may divert an inflam- matory attack, and is so evanescent that it will not influence any disorder which may assert itself shortly after. The experience of many observers has sanctioned also the administration of a laxative saline dose at the same time. The alimentary canal being so extensive in the ox is often laden with matter of an indigestible character, which will tend to aggravate local or general disorder. The Putss of the ox may be taken at the submaxillary artery, the vessel of the right side being felt by the right hand passed over the neck, while the left hand holds the left horn ; at the brachial within and rather to the front of the: elbow-joint, the hand being passed round the front of the limb to its junction with the trunk; at the large metacarpal above and behind the fetlock; at the middle coccygeal on the middle line of the root of the tail; at the carotids in the channel of the neck; and at the anterior auricular in front of the root of the conchial cartilage. Different practitioners make a practice of selecting each one INTRODUCTION. ; 63 of these vessels. The submaxillary we find the generally most convenient ; it is smaller and less firmly bound down, and therefore suffersmore displacement than the correspond- ing vessel in the horse; also the arrangement of the lower margin of the inferior maxilla and masseter externus are less advantageous for accurate determination of its position, and the pulse can not be estimated here when the animal is feeding. The brachial or radial artery will afford useful indications after a little practice; the large metacarpal is a vessel of considerable size, and can be conveniently felt without disturbing a patient who chances to be in a recumbent position. The pulse in the ox is small, slow, and frequent as compared with that of the horse, its beats average 46 per minute. In the young animal it is faster (55—65). Pregnancy causes irregularity of the pulse, and con- siderable increase in frequency. Digestion produces in- creased fulness and sharpness; and Dobson tells us :— * Animals in warm cowsheds and in plethoric condition will have the number of beats increased several strokes per minute as compared with their brethren in the straw- yard and the field.” Williams says:—“‘In the cow during rumination it may be observed that the pulse is 70 or 80 a minute, and the respirations not more than ten. Indeed, the pulse of the cow in a state of confinement, in so far as regards the number of its beats, cannot be de- pended upon in the diagnosis of disease; the states of pregnancy and obesity, the effects of artificial food, and of the activity of the lactiferous glands, as well as the ex- citement caused by the act of rumination, generally pro- duce such an impression upon the nervous system as to cause the action of the heart to be much increased, such increase being entirely consistent with a state of perfect health in an animal so circumstanced.” Useful information is gained by examining the heart’s action by auscultation, placing the head against the side. The “venous pulse” is the periodical change in calibre of a vein, which sometimes results from regurgi- tation of blood into it. It is seen at the jugulars in heart 64 BOVINE PATHOLOGY. disease, but in health generally the action of the carotid artery causes changes in the jugular which lead to appa- rently pulsating movements. The normal remprraTurE of the ox, as taken at the rectum, is 38° C.—38°5° C., according to Colin; 389° C. (Siedamgrotsky) ; 39° C. (Zundel) ; oxen and cows 100°8° F. during confinement, and 101°8° F. during work or at liberty; calves and stirks, 100-9° F. to 101-9 F. (Armatage)? Variations resulting from ordinary conditions of the system are but slight, seldom amounting to more than 1° F. Any rise above this must be considered suspicious as indicating the presence of fever. The reading will be higher in a young animal and lower than the normal mean in a very old animal. Ingestion of food, exercise, and change of external temperature cause slight variation. The thermal regulators of the body are very efficient during health. When fever sets in, escape of heat is prevented and its generation increased; in typhoid disorders and shortly before death heat generation is interfered with, and the temperature markedly falls. The rectum should always be the seat of thermometric observations in the ox, and the routine already recommended should be always carried out. The temperature of the vagina is somewhat lower. Respiration is performed in the adult ox about fifteen times per minute. The acts are slightly more frequent in the calf (18—20). They vary in number somewhat with surrounding conditions, but any marked increase or decrease in number must, if permanent, be attributed to disease. The increase which results from exercise quickly 1 Careful observations by Prof. Robertson and Mr. Singleton have proved ° Armatage’s estimates too low. They gave the following results : Fat cattle at Smithtield Show— Under 2 yrs. old, average temp., M., 102-05° F.; E., 102-39°; Resp. 32 Between 2 and 8 yrs., $s » 101°87°F.; ,, 102°3° ; 4, 28°4 39 3and4 ,, 5 x» 101°83° F.; ,, 102°11°; ,, 30:2 Over 8 yrs., 5 » 1019° F.; ,, 102:2° ; ,, 34 Various ages, 3 » 101°4° F.; ,, 101°4° ; 4, 29°08 Dairy cows— Various ages, $5 >» 101°5° General average, from 352 animals, cows and oxen, morning, 1C1°65° F.; evening (from over 200 animals), 102° F.; respirations 30°25. Variations in eaiee animals in health from 99°8° F. to 104°6° F.; respirations from 11 to 106. INTRODUCTION. 65 disappears when the animal is placed at rest. We have already alluded to the remarkable difference in position between the horse and ox suffering from pulmonary dis- order ; while the former stands persistently, the latter rests on the lower part of the chest and on the abdomen. The position which an animal assumes during an acute attack is often diagnostic or even pathognomonic. This may be seen in tetanus, in hoven, and many other diseases. The Covanof the ox is shorter and less powerful than that of the horse. It may become almost pathognomonic in certain diseases, as especially pleuro-pneumonia contagiosa. In our determination of disease of the ox, as in those of most other dumb animals, we have to rely principally on OBJECTIVE Symptoms, which are independent of the animal’s sensations, rather than upon those SUBJECTIVE in- dications conveyed by the animal himself. Nevertheless, we have a few of the latter to guide us, such as shaking of the feet in eczema epizootica, backing in pelvic hernia, and flinching when pressure is applied to the intercostal spaces in cases of pleuritis. The expression of the animal is often the means of conveyance of useful information to us; the retracted condition of the angles of the mouth in trismus, the wild look in rabies, the staring of the eyes under acute abdominal pain, and the altered expression due to opacity of the eye are familiar to most practitioners. General sensation is sometimes per- verted or lost, and is tested by inserting a pin into a limb presumed to be paralysed. The movements of the animal may be stiff as in tetanus, rheumatism, &c., or the inter- ference may amount to absolute lameness, due either to disorder of the affected limb or to sympathy with other parts, as may be observed in the lameness of the right fore-limb in liver disorder. The visible mucous mem- branes of the ox during health somewhat vary in colour. The Schneiderian is moist and pink, but under disease may ‘become livid, yellow, scarlet, or very pale, ulcerated, and covered with discharge of a nature varying according to the case, mucous, purulent, sanguineous, &c. The 5 66 BOVINE PATHOLOGY. lining membrane of the mouth is very dense in the ox, developed into horny papillae on the inner surface of the cheek and the dorsum of the tongue, and modified to form the dental pad at its antero-superior part. It sometimes exhibits abrasions either from coarse material taken into the mouth, or from the sharp prominences of the molar teeth. In other cases it has vesicles of a specific or ordinary cha- racter upon it ; in febrile cases it isdry. While observing its condition we can note also the characters of the saliva, which may be profuse, constituting PryaLism, as seen in injuries of the mouth or mercury poisoning, or defi- cient. Sometimes it is materially altered in quality, thus it may be viscid (“ropy”’) or fcetid, as in some cases of tetanus. In cases of enteritis and other abdo- minal inflammatory disorders, the rectum will, on manual exploration, be found markedly elevated in temperature, and its mucous membrane may protrude somewhat through the anus, being of a bright scarlet colour. In prolapsus recti it forms a rounded purple mass, its walls being thickened . by gelatinous deposit. This mucous membrane is the seat of tumours (hemorrhoids or piles) which may protrude after expulsion of the feeces. Manual exploration of the rectum of the ox presents no special features. The feces are soft, pultaceous, and form a rounded cake of a dark greenish-brown colour. They may be altered in quality or quantity, scanty or wanting as in constipation and costiveness, profuse in diarrhoea and dy- sentery, mixed with much mucus in the former and with blood in the latter case. The nature of the diet and the activity or inertness of the liver alter their qualities, while their odour also is very variable. The mucous membrane of the vulva may be altered in colour, ulcerated, or the seat of profuse discharge of a purulent, mucous, or san- guineous nature; it becomes congested during cestrum. The conjunctiva during health is of a rosy colour where it lines the eyelids, and transparent where it invests the cornea. In the latter position it may become opaque and clouded, in the former of a bright scarlet in cases of fever, yellow in liver disease, pale in anemia, &c. The INTRODUCTION. 67 tears may be profuse, as in local irritation, blocking of the ductus ad nasum, and in the early stages of catarrh ; acrid, as in certain blood diseases; mucous or purulent under inflammation. The eyes may be over sensitive to light, in consequence of which the eyelids droop ; frequently the Meibomian secretion is profuse and adhesive, and the eye- lids are swollen. The conditions of the alimentary canal afford some useful indications. Hxamination of the mouth may detect diseased teeth, presence of foreign bodies, &c. Enlargement may be present along the cervical portion of the course of the cesophagus, due either to presence of an impacted body, or to a dilated state of the tube. De- glutition may be difficult (dysphagia) or the appetite impaired or absent (anorexia). Navsza may be present or vomition, the former being an uncomfortable sensation, manifested by attempts to return matters from the stomach for expulsion from the body, the latter being a successful performance of the act. These are due to irritability of the stomach, and evacua- tion of the contents of the ramen somewhat readily occurs in the ox, in consequence of the adaptation of the cesophagus for regurgitation, as well as downward passage of food. Borzoryema is abnormal rumbling of the bowels, such as may be observed after administration of drastic purgatives. Often it depends on accumulation of gas in the stomach or intestines, FLATULENCE, or TyMPANY. The conditions of the abdomen, whether diminished in size, “tucked up ” as in acute disorders, or distended by gas, tumours, or food accumulations, should be noted. The size, movements, and general conditions of the thoracic walls also vary. The Usine oF THE ox normally has a specific gravity of 1080—1040, a yellowish-white colour, a special odour, and an alkaline reaction. Its chemical, physical, and micro- scopical characters vary much with different conditions of life and in disease. The specific gravity may be tested by the urinometer, or by specific-gravity globules. The urine will be found modified, under various circumstances, in quality and quantity, and especially in proportions of its. several constituents. 68 BOVINE PATHOLOGY. Tue Sern or THE ox éxhibits a fair amount of activity. Animals in health keep it clean by licking, and thus often introduce hairs into the stomach. Perspiration may occur generally or locally under disease, and the perverted con- ditions of the cutaneous secretions in weak patients, and those with a scrofulous tendency, as also dirt accumulations, predispose to local irritations, and invasion by vegetable or animal parasites. The expirep Arr has an odour characteristic of the animal, due to effete matter which it carries from the system. Its temperature and odour vary. Thus, it may be cold in later stages of asthenic disorders, warm in acute attacks, footid in gangrenous disease of the lungs. Our prognosis, when medically attending the lower animals, does not hold in view simply the chances of a fatal . result ; we have to consider our cases from a pecuniary point of view, and to determine promptly for the owner the length of time which will elapse before return to health, and also whether the value of the animal after recovery will be such as to make treatment an advantage to the owner. Prompt decision is especially called in a case of disease in the ox, for the flesh of an animal slaughtered in the early stages of some diseases, before the system has been interfered with by medicinal agents, may be used for human food. This seems to lessen our opportunities of tracing cases of dis- ease in the ox from commencement to termination, and proves a very sharp test as to the correctness of our dia- gnoses. We often have an animal brought under our notice in sufficiently good condition to fetch a good price from the butcher. The owner propounds the following questions in order :—What is the matter with this animal ? Will it be likely to die? How soon will it recover? Will it be reduced considerably ? and, if so, how long will it take to regain its present state of flesh? If it seems likely to die, it is at once killed, and our diagnosis verified or the reverse. If it is allowed to live, the prognosis is subjected to similar smart scrutiny. With milch cows the interference with milk supply is the source of the owner’s solicitude; while animals kept for breeding pur- INTRODUCTION. 69 poses necessitate considerations of the bearings of various disorders on the reproductive functions. In no branch of medical study does the practitioner require skill more than in cattle practice. The milk varies in quality and quantity, and its production has been much inereased by artificial selection. The first milk, colostrum or beastlings, is rich in fatty matter and worn-out, tough, epithelial cells filled with fat globules. It acts as a natural cathartic; freeing the bowels of the newly-born calf from the accumulation of biliary and other matters which constitute the meconium. The milk may be bloody, may contain pus or specific virus. It requires special examination in each case of disorder, for in some instances it can convey disease to animals of other species, ‘eventoman. Dears of the ox may take place by either of the above described methods, necremia being observable in such disease as anthrax, according to some pathologists, while others attribute the fatal result to asphyxia. With regard to MORBID CHANGES, the degenerations of various kinds are frequent, especially the caseous and calcareous, and the tendency of disease is to the production of deposits of a lymphy or serous character rather than to gangrene and ulceration. Abscesses are frequent, metastases seldom occur, hemorrhages are rather frequent. Inflammation tends rather to the chronic type, and is less frequent than in most other animals subjected to similarly complex conditions as the ox. Epizootic and enzootic diseases will occupy a great deal of our space as being of great importance, numerous, and widespread, causing immense annual loss to stock owners, and often directly related to human disorders. In the trzarment of the diseases of the ox palliative measures are often important as giving time for fattening or as preserving an animal useful for breeding or dairy purposes. Curative means of medicinal character are often hampered by our deficiency in information as to the specific influence of certain agents on the ox and the doses in which they should be administered. Surgical opera- tions of minor importance as cesophagotomy, tracheotomy, 70 BOVINE PATHOLOGY. and puncture of the rumen are frequent, while major operations, amputations, lithotomy, laparotomy, &c., are occasionally resorted to and might be more frequent, but we have already mentioned how our bovine patients are frequently handed over to the butcher without our having had a fair trial of curative means. In accordance with paucity of major operations anesthetics are seldom re- sorted to, but various means of restraint are adopted. Altogether cattle are not endowed with high nervous organisation, and will therefore stand operations very well, and are correspondingly seldom the subjects of collapse.’ Thus artificial respiration is not very frequently required, fortunately so, for when brought about by pressure rhyth- mically applied to the thoracic walls it is imperfect, and seldom effectual in our larger patients. The ox is usually Fie. 6.—The “Bulldogs” applied. (Armatage.) held by one horn, the thumb and forefinger of the dis- engaged hand being introduced into the nostrils and pressed together against the septum narium, or the familiar ‘‘bull-dog” is fixed to the nostrils in a somewhat similar manner and held in the hand. (See Fig. 6.) 1 A case of death from collapse under operation has been recorded in the specimen issue of the ‘Quarterly Journal of Veterinary Science in India,’ the Peet being an artillery draught bullock affected with aneurism of the carotid, INTRODUCTION. 71 The Sipexrve is sometimes fixed on the ox as on the horse. In minor operations on the posterior parts of the body, the hind legs are fixed together by means of a double hobble or tied by a rope, which commences at the right hind limb, involves the left in a loop, and is tied in front to the right fore limb above the fetlock. This is termed * shackling.” Peuch and Toussaint give the following methods of restraint of bovine animals in a standing position :—To fiw the head, with a view to prevent assaults and to limit the brusque movements of the animal : (1) Hold his head by horn and nostrils (sec. art.). (2) A cord tied at one end to the horns, then laced (first) round the sides and (second) round the flanks and tied round the root of the tail will prevent him getting his head down to charge, by the pain the dragging would cause at the root of the tail. (3) Tying the head either to a tree or post. (a) The fore- head is placed against the post, then a running knot of cord is fixed around the base of say the right horn, from which the cord first passes round so as to embrace the left horn ; it then comes again round the right, over the neck, and round the post to the left; the end of the rope is then passed between the head and the post, and brought down along the face, looped round the muzzle, and the end given to an assistant. (6) The beast is fixed with one side of the neck resting against the post, one horn also against the latter. The loop of cord is fixed on the left horn, looped round the base of the right horn, brought round the post from left to right over the neck, round the left horn again. It is brought round in the same way a second time, then over the face, looped round the muzzle, and held by an assistant. (4) Sometimes an animal is controlled by fixing him under the yoke with another ox. To limit the movements of the limbs and prevent attacks. —The ox strikes forward with the hind limbs, backwards with the fore limb (when raised), shifts suddenly side- ways, or throws himself down. Bouley recommends the following methods: (1) To 72 BOVINE PATHOLOGY. hobble together the hind limbs. (2) To bring the tail between the hind limbs, around the thigh of the limb which threatens the operator, and to have it held firmly by an assistant supporting himself by one hand against the hip. (3) Place a tourniquet (such as a twitch) above the hock, and tighten until the tendo Achillis rests against the back of the tibia. (4) Raise the hind limb from the ground by a rope tied round the pastern, and fix the other end of the rope either to the forearm or to the horns. (5) Have a pole held in the bend of the two hocks by two assistants. (6) Or use the pole as a lever, by means of which the body may be kept firmly against a wall and forward bounds prevented. The pole is supported obliquely from the ground of the side opposite the opera- tor and brought in front of the stifle. An assistant then supports the upper end on one of his shoulders, and uses the pole as a lever to shift the animal up to the wall and keep him there. Or two poles may be used, one on each side of the animal, by which means he can be turned as required. (7) Or the animal may be fixed against the wall by a strong strap running from a ring just in front of the chest to a ring behind the buttocks. (3) To control a bull and move him about as required are used (a) Bull-dogs of various forms, (b) rings (of dif- ferent patterns), with ropes or conducting staffs, such as that of Roland and that of Vignon. Peuch and Toussaint describe and figure Goffon’s trevis as used. for the ox. To put a ring in a bull’s nose.—Fix him, stand on his right side, perforate the nasal septum from the right with a trocar, leave the cannula in position until in it has been fixed one end of the ring, then withdraw the cannula, and fasten the ends of the ring together. To cap the horns.—Place on their tips caps of wood or copper and fix with a screw or rivet inserted transversely. Hozsizs are also used for throwing the ox. It is advisable to fix them above the fetlocks. Calves may be thrown by drawing one hind leg forwards with the side- line and pushing at the opposite quarter. INSTRUMENTS OF CONTROL. B Nose ring (Roland’s), open and closed. (Peuch and Toussaint.) Conducting staff (Roland’s). (Peuch and Tonssaint.) [To face page 72. 7 Y Goiffon’s Trevis. (Peuch and Toussaint.) INTRODUCTION. 73 Ropzs. The ox is very frequently thrown just as is the horse when the long cart rope is used for securing the animal for castration. (See Fig. 7.) Fie. 7.—An Ox prepared for casting. a. Seat of incision in ruminotomy. (Armatage.) Peuch and Toussaint describe in detail two methods suggested by Rueff (Reportorium f. Thierheilkunde). The Jjirst consists in taking a cord about five-and-twenty-feet long, doubling it and looping it at the centre, fixing the loop on the horns, passing the ends between both fore and hind legs, bringing them from within outwards around each pastern, and then through the loop round the horns, which is to act as a pulley. Two assistants (at a signal from the operator) pull the ends powerfully ; this causes the animal to sink down or to yield behind and finally be stretched on the litter. Assistants must also drag at head and tail to aid in throwing the animal, and any resistance on his part will only make him fall the more promptly and the ropes run more freely. The second method (called “Entangling ”’) is that commonly used by the natives of India. Gurlt and Hertwig also mention it. The animal should be kept short of food for some time. A rope similar to that used in the first method has a running knot at one end, which 74, BOVINE PATHOLOGY. is fixed around the horns. The rope, well lubricated with lard or soap, is then brought along the dorsal margin of the neck as far as its posterior third, where the first loop is formed; it then is carried backwards above the withers and the second loop formed behind the shoulders, the third loop is formed around the flanks and belly, and then the end of the rope brought straight backward along the sacrum. ‘Two assistants drag the cord to the side opposite that on which the animal is to fall, and one at the head tries to throw him. The traction tightens the loops and the animal soon flexes his limbs and lies down quietly. In India the neck loop is not formed, and the animal is often pushed over before he goes down of his own accord. Casting is therefore a frequent cause of fracture of the hip-joint and neck of the femur in that country. Dressing the feet of the ox, as in eczema epizootica, may be effected either by means of a long stick with some tow fixed on the end, or, when the hind feet are to be treated, by raising the foot towards a beam by a hobble fixed above the hock, the rope passing from it over the beam and its free end held by assistants. Another method is to pass a pole between the hind legs and have the limb sup- ported just above bend of the hock by a man at each end of the pole in such a way as to raise the limb as much as required. Slinging of the ox is not often resorted to. It too much interferes with digestive and respiratory processes. Four drachms of chloroform administered to a two-year old heifer caused slow and laboured respirations at the end of a minute, at two anda half minutes the animal staggered, and at three and a half minutes fell to the ground. At six minutes the breathing had become more laborious. At six and a half minutes the animal seemed completely insensible, the pupils were fully dilated, the conjunctives congested. The sponge was now removed. At ten minutes respiration became quick and agitated ; at eleven minutes the animal got up but had much difficulty in standing ; shortly afterwards it staggered into the straw- yard. Morton gave four ounces of chloroform toa heifer INTRODUCTION. 75 and it produced no insensibility, the animal only seeming to be intoxicated by it (‘ Veterinary Record,’ vol. iv). Method of administration of chloroform to large animals. —It is essential that the animal be cast previous to administration, otherwise he will be uncontrollable in the preliminary stage of excitation. Then a due admixture of air must be ensured by the use of an apparatus with two tubes, one of which communicates with the outer air, the other passing from the chloroform vessel, each fitting at the other extremity into a nostril; several inhalers varying slightly in form have been suggested. Or a sponge with chloroform poured on it may be held against the muzzle, and the hand and muzzle loosely covered with a cloth, the chloroform being renewed from time to time. The amount of chloroform essential for the production of insensibility to external impressions varies much in different cases, and must be regulated by the judgment of the chlo- roformist. If after the operation is completed the animal does not regain sensibility sufficiently soon, cold water may be thrown over the body and air freely admitted. Why nursing should not be utilised to the full in treatment of cattle affections, when circumstances are favorable, we cannot say, but in some quarters there seems to be a prejudice against nursing an ox. It must be our duty in every case to ensure such nursing means as we have already indicated, they will very materially assist our medicines ; even rough methods of preserving a com- fortable warmth of the surface of the body and a due supply of fresh air, and a draught of cool water so refresh- ing to the palate of a feverish patient, are valuable. The prevention of disease consists in the careful super- vision of those details of management which experience has suggested as best for various kinds of animals, but it assumes a special character when we are requested to check the ravages of an epizootic in a herd or to prevent access of a dreaded disorder. In such cases ISOLATION must %e rigidly enforced, all predisposing and exciting causes must be removed or obviated. The slightest trace of disease, of any kind, in 76 BOVINE PATHOLOGY. one or more of the animals, must lead to sEGREGATION. Measures of pisinrection of houses, utensils, and atten- dants, must be carried out with energy; and to effect this, the manager of the herd must be a thoroughly reli- able man. Under these circumstances we shall probably succeed in our efforts to prevent or limit an invasion. Section 3. In the present section we will place before our readers as succinctly as possible the therapeutical actions of such medicinal agents as have been utilised in the treatment of cattle, availing ourselves of modern thera- peutical ideas, of the researches which have recently been occupying observers of the actions of medicines, and of the assistance of the several works on veterinary medicine and pharmacy, which have been presented to the profes- sion. We shall follow in the main the system adopted by Headland in his most admirable ‘Action of Medicines,’ adapting this to our special requirements. We shall use the tabular form as most economical of space, and shall so arrange matters that we may utilise our system after- wards in our notice of toxicology. For ADMINISTRATION to the ox agents are generally prepared in a draught (or “ Drench”), soluble matters being dissolved in the water, which is usually the principal vehicle, insoluble matters being in a state of powder and suspended. Drenches are preferred for the ox because they can be readily ad- ministered, act sooner than solid masses, and probably al- most always mainly pass into the third and fourth stomachs! directly without delay in the rumen, and the chance of rejection during rumination. In practice, a bottle with a gradually tapering neck is found to be useful for ad- 1 Finlay Dunn, discussing this matter, says, “It is a very prevalent notion that medicines, when poured very slowly down a cow’s throut, pass, like the ruminated food, direct to the fourth stomach. From a number of observa- tions made at the slaughter-houses on both cattle and sheep, I find, however, that neither animal can be induced to exert this voluntary effort in behalf of our medicines, which in all cases, no matter how slowly soever they be given, fall into the first and second stomachs,”’ INTRODUCTION. 77 ministering the dose. Generally the head of the patient is straightened on the neck by drawing the muzzle forwards and upwards, the nostrils being grasped so as not. materially to interfere with respiration. Preferably, however, the head is flexed to the right, and the admin- istrator stands with his back against the right shoulder, keeps the left hand partially in the left side of the mouth, and gives the draught with the right. The opening of the bottle is then inserted into the mouth, and the contents gradually allowed to pass down towards the pharynx; sometimes the drenching horn is used, but the _ bottle is preferable as giving continuous, steady, and ready flow. This operation is much easier than adminis- tration of a draught to a horse, the ox receives his drench more quickly, and loses hardly any. It is necessary to cease the operation when any sign of coughing appears. An ordinary cattle drench measures from a pint and a half to two pints. Cases of suffocation from passage of fluid into the larynx and trachea occur sometimes, as we shall detail hereafter. This is liable to take place in attacks of parturient apoplexy, and must be avoided by giving any medicines the animal requires by means of the stomach pump. Some practitioners consider balls useful aa Fig. 8.—The Stomach-pump in use. (Armatage.) for the ox, others as strongly object to them. Aloes may be conveniently and beneficially administered in this 78 BOVINE PATHOLOGY. form; its active principle is soluble in alkaline solu- tions, such as the secretion of the rumen, and hence becomes more rapidly absorbed than it would have been if it had passed at once into the true digestive stomach. Few other agents are better given in solid form than in a drench, powders do not harmonise well with the ordinary food of the ox, and would probably pass directly into the huge mass of masticated matter in the torpid rumen of the diseased animal. Enemas (injections, clysters, or glysters) may be either gaseous or liquid. The former, as tobacco smoke, &c., are well worthy of more frequent trial. They are easily administrable, and prove local sedatives in enteritic dis- orders. They are administered with an enema tube con- nected by a long flexible pipe with a vessel in which tobacco is burnt. Liquid enemas are administered to produce either local or general effect. In the latter case they form the vehicle of such agents as are most readily absorbed from the large intestines such as strychnia. Locally, they act as fomentations, demulcents, and laxa- A) ¥ Pp 1 s Deen 4) : Fie. 9.—Application of steam to the nostrils. (Armatage.) tive means. In the latter respect they are most useful, INTRODUCTION. 79 softening any fecal accumulations, and arousing peristalsis in a simple but effectual manner. They should be admin- istered in such quantity that they will be retained for some time, and may be injected by means of the enema syringe, Reid’s pump, or the gravitation funnel. Inhalations of chloroform, steam, chlorine, and carbolic acid are used in cattle practice, the first has been noticed as anesthetic. Chlorine, under the form of Vapor Chlori, is generated in a loose box or stable, into which are collected calves suffering from bronchitis parasitica. It acts as a Fia. 10.—Method of covering the nostrils for steaming. (Armatage.) very powerful irritant, gives rise to distressing cough, and expulsion of numbers of the strongyles:. which cause the disorder. Vapor Acidi Carbolici is generated for internal disinfection by pouring some of the Calvert’s acid into a pan resting on a tripod, a box in the bottom of the pan holding a red hot flat iron heater. The box and the animals become thoroughly disinfected, but the beneficial effects have not been proved as far as internal disinfection is concerned. The thickness of the skin of the ox prevents frequent taking up of medicinal matters into the system after in- unction. Intra-venous injection is sometimes practised, as also is the absorption of medicines from an abraded sur- face, but administration of agents by the skin may best 80 BOVINE PATHOLOGY. be by subcutaneous injection. The syringe for this pur- pose (seo Fig. 11) is small, and can conveniently be carried in the pocket; has its barrel graduated, and made A ce Fiq. 11.—Hypodermic Syringe. (Armatage.) of glass; generally has a handle to its piston, every complete turn of which expels a known quantity of the contents, and a nozzle shaped like a trocar with a side opening of exit. The puncture is scarcely noticed by the animal, and should preferably be made where the subcutaneous areolar tissue is plentiful and the skin thin, By this means ex- tremely small doses of very potent agents may be given with certainty in solution of not more than one ounce measure. We must conclude, then, that methods of administration to the ox are seldom other than by drench. M. Taborin estimates the dose for the ox to average 3ths that requisite for the horse, but specific differences between the animals, as far as the actions of different agents go, render this useful conclusion not always reliable. He also reckons the ox’s dose three times as large as that for the sheep. Hertwig suggests for an animal aged one to two years half a dose, six months to one year one quarter, three to six months one eighth, and one to three months one sixteenth. Pregnancy and lactation and other conditions also influence the dose, and we must remember that many agents administered to the cow pass off by the milk and affect the calf. It is thought that all “agents which produce their effects upon remote parts of the system must be absorbed and added to the blood.” ‘The phenomena of certain cases of poisoning hardly enable us to accept this dictum unreservedly, When very large doses have been taken INTRODUCTION, 81 death completely and immediately occurs, seemingly similar in its characters to that which has been seen to result from a blow on the epigastrium. These observa- - tions on poisoning in man apply to animal poisoning, but this “death by shock” is quite the exception. When agents enter the blood they circulate in its current and act upon various organs. Accordingly they are divided into hematics, neurotics, eliminatives, and astringents. ete H CR ax, See eee ST gs tee ae ROSS SINT INST rod Fic. 12,—Clyster Syringe, with elastic tube and ebony pipe; used also as 4 stomach-pump. 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