G*rtkefte upon the employment of his favorite remedy, for different complaints. He has lately written an article upon the cholera, in which he lays down the following propositions ': " The primary cause of cholera is, as a general rule, the excessive heat of hot climates, and temperate climate in sum- mer when cholera prevails. The proximate cause of cholera is of precisely the same nature as that of summer or cholera diarrhoea, but it is far more developed, and conse- - quently its action is proportionately more powerful and intense." CHOLERA LANDMARKS IN NEW YORE!. As !New York City, from its position, is pretty certain to be visited by the dreadful scourge, anything respecting its con- dition will prove of interest. Surely it must be instructive to note the quarters in which cholera has in former years made its first appearance. The first epidemic of this disease in New York, broke out in the vicinity of Cherry and Roose- velt streets, appearing also at the same time in Reade, Wash- ington and Duane streets. Of course the Five Points, which . had then all the peculiar characteristics it has since lost, was violently attacked, as well as the whole region of the Sixth Ward. A section of Laurens street, between Graud and HISTOHY OF THE CHOLERA, 23 Broome* expressively called "Rotten Row," became another center. The same may be said of Corlears Hook, and any- body who has been up town in cars of the First and Second avenues, -might recall spots which promise to become cholera favorites. In the epidemic of 18-19, the first appearance was at Nos. 21 and 23 Baxter street, and next at Nos. 8 and 10 Mulberry street. The physician of the first established cholera hospi- tal gives this picture of the spot where the disease first broke OUt : u No. 20 Orange (now Baxter) street, lies 30 or 40 yards in a southeasterly direction from the Five Points. The en- trance to the rear lot is gained by an opening scarcely two feet wide, or more than six feet in length, pierced through the front house. Passing through this a distance of forty feet, you reach the rear lot, on which are two old and ruin- ous tenements, one a prolongation backward of the front house, and the other standing across it at right angles ; the adjoining house an extension backward in the same manner, thus cutting off almost completely the admission of fresh air. The small area that is unbuilt upon is covered,.with black pools of filthy water. The apartment where the first case occurred is a basement or cellar in one of these buildings. * * * At my first visit on the 16th of May, five human beings, one man and four women, lay upon the floor in differ- ent stages of cholera. There was nothing under them but mud and filth, and nothing over them but a few rags of tire filthiest description. Civilization and a great city could scarcely afford a parallel to the scene." For two weeks the disease stayed in this locality; then appeared in a filthy quarter in Stanton street, afterward in the region west of the New York Hospital on Broadway— the same qu art er now occupied largely by wholesale dry-goods bouses,! and traversed continually by street-cars of two or three lines, where smallpox and typhus have raged, with scarce an intermission, for nearly two years. The c»iolera in 18±9 showed a like beginning in other cities. In Philadelphia it appeared.in two districts where cleansing had been inadequately performed ; but the work 24 HISTORY OF TIIE CHOLERA. was taken hold of in such earnest that 2,700 privies were cleaned, 340 houses cleaned by authority, 188 ponds drained, 66 rag and bone shops closed, and 6,000 sources, of disease in all removed, so that in that city but 747 persons died, while in New York the number was 5.071. In Boston the disease commenced and remained in three or four narrow lanes in the northern and most crooked portion of that crooked city. Citizens whose homes are on the avenues and the spa- cious cross-streets have no idea of the nooks and holes where cholera may delight to make its fearful dwelling- place. Pass up Cliff street, above Frankfort, and the place will be reached, lying in a rude triangle inclosed by Cliff, Frankfort, and Vandewater streets. Through a tenement house on' Vandewater street is a narrow alley (four feet wide) which forms the only communication with five other houses, standing first three, then two behind them, a small court, in which is ^ their common privy, being between. Those furthest back from Vandewater, street abut against four others, which in turn touch three others fronting on Cliff street, while stables and tan-vats conveniently occupy the angles^, and a soap factory faces them all from the fur- ther side of Cliff street. Cholera might naturally enough make its headquarters here. CHOLERA IN OLD HAXNTS OF DISEASE. ' Dr. Laycock, in his highly interesting Report on Health, s'ates that the cholera of 1831 in England selected nearly all the old haunts of the plague, ami appeared to possess a predeliction for the old haunts of disease. " It is a singu- lar, coincidence, " he remarks, "that while the cholera com- menced in the Haymarket, near the traditional spot of the plague under consideration (in 1604), and probably near to that of 1551, the first death from cholera took place also in the parish of St. Michael, Spurriengall, and on June 5;h." It was in this parish, and on June 4th, 1604. that the first death from the plague occurred. The first case that occurred in Edinburgh in 1848, took place in the same house, and within a few feet of the same spot where the epidemic of 1£32 commenced its course. On its reappearance in niSTOEY OF TITE CHOLERA. 25 the town of Pollocksliaws, it Snatched if s. first victim from the very same room and the very bed in which it had bro- ken out in 1832. Its first appearance in Bermondscy was . close to the same ditch in which 1he earlier fatal cases occurred in 1839. At Oxford, in 1839 as in 1832, the first case occurred in the county jail. This return to its former haunts has been observed in several other places, and iho experience in foreign countries has been similar. At Grouingen, in Holland, the disease in 1832 attacked, in the better part of the city, only two houses, and the epidemic broke out in these two individual houses on the visitation of 1848. But it was observed, that while in both epidemics, those of 1832 and 1848-9, the disease was localized in pre- cisely the same disiricls, several of them having changed plnces in the relative degree in which they have suffered. The earliest case of cholera in Chelsea (near London), in 1848, is said to have been in Whitehall Court, and there it continued to exist until the end of the epidemic in 18-19.. The first case m 1854 was in the same place, perhaps also in the same house, in both visitations. A very similar fact is presented by Augusta Court, in which the three earliest fatal cases of cholera, in Chelsea, occurred in February, 1832; and which being revisited. in 1854^ continued to fur- nish victims to the pestilence throughout the. early dura- tion of the outbreak. Kent and Mew-streets, Sonthwark, on the south side of the Thames, London, which were severely visited at an early period of the last epidemic, were also among the first seats •of cholera in 1832. Dr. Aclancl relates that, with one ex- ception, every yard and every street in St. Thomas's parish, Oxford, England, which had been attacked by cholera in 1832 and 1849, was revisited in 1854. It is evident from these and many more analogous facts, that, although we are unable to explain all the conditions for the development of cholera, it is impossible for us to deny the great influence of locality on its production. IN BERLIN. . No surprise need be felt that Berlin was scourged with the cholera in 1831, and again with still greater severity in 1837. . 26 niSTORY OF THE CHOLERA. Putting aside drainage, the Prussian capital is, in the width and general arrangement of the streets, and the better ventil- lation of the houses, superior to the French : but yet 'the pro- portionate-mortality from cholera was much greater, or at the rate of nearly 2 1-2 to L in 1831, in the former than in the latter city — which, as commonly described, was so greiifc a sufferer. In the second attack (in 1S3T), the mortality was still heavier in Berlin, or, as the difference between 1,420 and 2,174 deaths. Berlin was then so far behindhand in the comforts of life, as not to hare water conveyed in pipes into the city and the houses. Three hundred thousand people have taste enough to be in dreamy ecstacies at the singing of Madame Pasta,, or the dancing of T aglioni, and have not taste enough to appreciate or feel the want of a supply of water in their kitchens, sculleries, drains, sewers, and wa- ter-closets. NARCOTIC POISON". ' The narcotic poison that is the remote cause of cholera, possesses a deadly enmity to the electric life that exists in both the blood and the body of human beings. The poison of opium produces, says Dr. Stevens, a similar deadly effect on the life of the blood and the body, consequently, the ex- perience derived from thousands of fatal cases, proves that the inhuman invention of adding the poison of opium to the poison of cholera is, when used by itself, or with brandy, or chalk mixture, the certain means of causing death in every severe case of the new disease. For even in the less severe cases, where the patients do not become collapsed, the pri- mary calm produced by the deadening effect of the opium is followed by a reaction in the vascular organs, in the form of a symptomatic fever, that is nearly as fatal as the collapse stage of the true cholera. IMPFRE WATER,- The effect of impure water is shown in the ravages of cholera in two of the southern districts of London. ■-. It is re- lated as follows : " These districts (comprising nearly a fifth of the popula- niStOHY OF TTTE CTIOLF.KA. 27 tion ofthd Metropolis) have been notorious for the great se- verity, with which cholera has visited them. Throughout these districts, during the epidemics of 1853-4, there were distributed two different qualities of water ; so that one large population was drinking a tolerably good water, another large population an exceedingly foul water: while in all other respects these two populations (being intermixed in the same districts, and even in the same streets of these dis- tricts) were living under precisely similar social and. sanitary circumstances. And when, at the end of the epidemic pe- riod, the death-rates of these populations were compared, it was found that the cholera mortality in the houses supplied by the bad water had been three and a half times as great as in the houses supplied by the better water. This proof of the fatal influence of foul water was rendered still stronger by reference to what had occurred in the epidemic of 1848-9. For on that occasion the circumstances of the two popu- lations were, to some extent, reversed. That company which, during the later epidemic, gave the better water, had given, during the earlier epidemic, even a worse water than its rival's; and the population supplied by it had at that time suffered a proportionate cholera mortality. So that the consequence of aniiiiiprovement made by this water-com- pany in the interval between the two epidemics was, that whereas, in the epidemic of 1848-9 there had died 1,923 of their tenants, there died In the epidemic of 1853-4 only 611 ; while among the tenants of the rival compan} T (whose sap- ply between the two epidemics had . been worse instead of better), the deaths which in 1848-9 were 2,880, had in 1853, " 1854, increased to 3,476. And when these numbers are made proportionate to the populations or tenantries con- cerned in the two periods respectively, it is found that the cholera death-rates per 10,000 tenants of the companies were about as follows: for those who, in 1848-9,. drank the worse water, 125 ; for their neighbors who, in the same epi- demic, drank a water somewhat less impure, 118 ; for those who, in 1853-4, drank the worst water which had been sup- plied, 130; for those who, in this epidemic, drank a compa- ratively clear water, 37." 28 HISTORY OF TITE CHOLERA. Dr. Sutherland, in his report to the General Board of Health on the cholera epidemic of 1849, says, that the ; rious effects of unwholesome water had been manifest in nearly every affected place — and adds, that a number of most Severe and fatal outbursts of cholera were referable to no other cause. Since that time, much additional evi- dence of a confirmatory character has been collected. Two examples are recorded by Dr. Acland, in his valuable and in- teresting "Memoir on the Cholera in Oxford" — the parish of St. Clements, which suffered a large mortality in 1832, when the inhabitants had filthy water from a sewer-receiving stream, and an insignificant mortality in 1849 and 1854, when the water was derived v.from a purer source. The other case is that of the county jail, in which cases have oc- curred in every epidemic, whilst the city jail, which is not far from the other, has uniformly escaped. The only appa- rent difference between the two establishments in 1854, seems to have been that the supply of water for the use of the county jail, and of which the soup and gruel were made, was pumped from a filthy well-pool, within ten feet of one • of the prison drains. No sooner were the supply pipes dis- connected with this impure source, than cholera and diarr- hoea ceased. It appears from an elaborate inquiry by the General Board of Health, at the close of the cholera epi- demic of 1854, that the contrasted effects of the dis- ease on the people of two large sections of the popu- lation, are only explicable by the fact that one division, com- prising a population of about 268,171 persons, drank impure water; whilst the other, numbering about 166,906 persons, used a clearer, and comparatively pure water. The mortal- ity from cholera among the drinkers of impure water — of water impregnated with the sewerage of the metropolis, and containing in solution a large quantity of saline matter, de- rived from the intermixture of sea-water— being at the rate of 130 to every 10,000; that of the drinkers of the pure water being only at the rate of 37 to every 10,000 persons living. • In the report on Epidemic Cholera in London, in 1854,- by Dr. Sutherland, much interesting information is afforded ITISTOTCY OF TTTE cnoi.EEA. 29 on the influence of water upon the spread of the disease. The (.led net ion from the microscopical and chemical examin- ation of the water used in the houses and neighborhoods where the disease was most; prevalent, by Dr. Hassall, was: "That there is no water supplied to the metropolis that does not contain dead and living organic matter, animal and vegetable. But the Thames Ditton water, supplied by the Lambeth Company, is by much the purest of' the waters, while the Southwark and Vauxhall water is one of the worst, and the waters of the other companies might.be ar- rayed in a series between these two." From an inquiry instituted by the Registrar-General, the following results appear: "In 26,107 houses that derived the water from Ditton, SI 8 deafehs from cholera occurred in ten weeks. In the 40.0-10 houses, that received the impure water from Bat- tersca, 2,445 persons, it was ascertained, died from cholera in the same time. The deaths in the latter districts exceeded by nearly 2,000'thc deaths that would have- occurred if chol- era In ad only been as fatal as it was in the houses that derived their water from Ditton." Dr. Sutherland makes the follow- ing remarks upon these results: "When it is considered thai', the sanitary condition of the population does not. mate- rially differ,, except in the quality of the water supplied by the two companies, it is difficult to resist this statistical evi- dence of the predisposing effect of the Battersea Water, and of the loss of life which has arisen from its use." The deleterious effects of impure water are not seen in cities or large towns alone: they occur in small villages, sometimes in the solitary farm-house — any place, in fine, in which the pump or draw-well is in the midst ol a farm-yard or filthy oonrt : receiving the surface-drainage of heaps of stable manure, pig-sties, &c. How often do we notice, says Dr. YV...J. Cox. green, slimy, stagnant pools, in the close . vicinity, and affording the sole water-supply, of cottages. Such a state of things does not often occur in this country; but in too many instances there is a neglect to obtain an adequate supply of pure water, the penalty is paid in the fre- quent occurrence of bowel-complaint, and the sudden in- roads of epidemic cholera, which makes its attacks without 30 history of TiiR dior.ROA. any other apparent provocation. In Hie new settlements of the West, the enterprising pioneer and life family often pay a tax in: the shape of disease, and not seldom of luei.t.self, from the use of had water or its imperfect supply : and in new towns other schemes of improvement are tiled, before sanitary measures, both for present and future protection^ such as paving, drainage, and a supply of good potable w ftter, are thought of. "Dr.- Cox tells us, that water tainted with various orrank matters, whether gaseous, as carbide or sulphide of faroro- gen, or solid, as putrescent vegetable fibre, or vitalized as algae, conferva, hydroe, fungi, infusoria, && — is a very fre- quent cause of severe visitations of bowel complaints during the summer months. Several instances cyme under his own observation, in 1853 and 1854, of the aggravation ofepid«*m3* ie diarrhoea from this cause. " That water falling • n a grow- ing soil, and running off to lie in stagnant pools, is sure to become tainted with animal and vegetable life, is well known: and when to this is superadded the circumstances of the said soil being highly -charged with effete organic products, the water thus collected must necessarily be highly impure, and most unfit for human consumption." POVERTY A CAUSE. .The poor suffer great privations and submil to many in- conveniences ; and the cleanly aim »ng them deserve tn'»ra consideration than they receive. Even in the homes of poor men whose wives are really cleanly, the former see with aching hearts the approach of washing day. When this needful sanitary operation is performed once a week it is a time of discomfort and unpleasantness ; but in inosl ler.cmented dwellings there is a washing on almost every < ! av of ihc week Quarrels arise among the numerous in- habitants of a house respecting the day on which they ean have the use of the lines and drying apparatus in the space which is often for too small and, very meonyenieuU Ii is by no means an uncommon practice, in order to save. fuel. time, and so on, for one woman to leave the hot, dirty water in which her clothes have been washed, for the us 7. Inculcate habits of personal neatness. 8. Avoid the employment of purgative drugs, except when prescribed by your physician. 9. Avoid and prevent effluvia from excrementitious mat- ters, sewers, privies, or chamber vessels. Frequently and thoroughly disinfect these sources of fever poison. 10. Insist upon the utmost cleanliness and purity of every portion of your apartments, furniture and domicile. HISTORY OF TIIE CTTOLERA. 49 11. Thoroughly and frequently ventilate every apartment in the dwelling, even to the cellars, closets and vaults, This should be aided by fires in open fire-places, wherever available. 12. Carefully protect the body against sudden alternations of temperature. ATear flannel, and when exposed to change- able temperatures, or suffering any disorder of the bowels, wear a broad flannel band extending from the top of the hips to the middle of the body. - 13. Be prudent in the use of food and beverages, being particularly attentive to quality and digestibility. 14. Bear in mind the fact that a painless diarrhoea is the most invariable precursor of cholera, and that if not imme- diately and properly treated, it will more probably termi- nate fatally than favorable. \ * RULES TO BE OBSERVED IN CASE OF ATTACK. 1. Soon as attacked by the premonitary diarrhoea or any symptoms of cholera, seek immediate repose in a recumbent position, where warmth and a pure atmosphere will be en- joyed. Immediately procure competent medical attendance. 2. Let the excrementitious matters from the sick be disin- fected in the vessel soon as voided, by means of carbolate of lime, sulphate or proto -chloride of iron, coal-tar, carbolic acid, or permanganate of potash ; and let no person directly use the privy into which such materials are emptied while cholera is prevailing. "Wherever practicable let the evacu- ated matter be deeply buried in the earth, and immediately covered with quicklime, or coal-tar and gravel. 2. Let all the vessels and clothing that are used by the pa- tients, be immediately cleansed with boiling water and soap or alkaline chlorides, or permanganates. 4. Preserve the utmost degree of personal cleanliness of the sick, and of their attendants. ON CLEANSING AND DISINFECTIONG. Putrefaction and the effluvia from effete organic matter, are among the most active and preventable of the localizing causes of cholera and fevers. To prevent such evils, and 50 HTSTOKY OF TIIE CHOLERA.. destroy noxious exhalations, is the chief object of all the processes of cleansing- and disinfecting. Water is the uni- versal agent of cleansing. The I rife value of baths, clothes- washing, scrubbing, and flushing, will never be properly appreciated until the relation of these homely duties to the prevention of infection and disease is more generally under- stood. Sewers, house-drains, water-pipes, arid water- closets, should be frequently flushed with water — let on in the largest practicable volume — for thorough cleansing ; water-closets, privies, and waste-pipes in houses should be flushed in this manner every day. Infected clothing and the utensils used in the sick room should be washed or scalded in hot water the moment they are removed from use. It is recommended that the cloth- ing of the sick with fefcat disease should be immediately plunged into boiling water,, or soaked in a w.eak solution of chloride of lime, or permanganate of potassa. Of the for- mer, 1 oz. to the gallon of water is sufficient ; or of the latter, a few grains, or just sufficient to give the water a slightly reddish tint ; this is a powerful disinfectant, and if boiling heat cannot at once be applied to the contaminated garments, the permanganate fluid should ^be employed. Soap and other alkalies are valuable aids to water-cleans- ing. Currents of fresh air, and all methods of ventilation, cleanse'by oxidizing and drying. Ventilation, therefore, is no less a purifyer than water. Drying tends to arrest putrefaction, therefore it purifies, and should be effectively applied wherever practicable, particularly upon the walls and floors of domestic apartments, in closets, cellars, court- yards, and stables. The application of quicklime , rapidly promotes the drying of places upon and near which it is spread. It also arrests putrefaction. HOW TO USE DISINFECTANTS. 1. Quicklime. — to arrest putrefaction, to act as a rapid dryer, and to decompose certain moist and hurtful affluvia, sire w the dry lime upon the earth ; or, distribute upon plates, etc. HISTORY OF THE CHOLERA. 51 2. Chloride of Lime. — Employ this for same purpose as quicklime, also as one of the cheapest sources of chlorine. One pound of this substance will usually disinfect about 1.000 gallons of fluid sewerage. To mix immediately with offeusive materials, it may, for convenience, be combined with water in proportion of 1 lb. to the gallon. 3. Chloride of Zinc. Pr do- Chloride of Iron, Sulphate of Iron, or Nitrate of lead.— Make a saturated solution of the salt, and use such solutions diluted in eight or ten times the quantity af water. 4. Chlorine Gas. — When required more copiously than it would ordinarily be given off by the Chloride of lime or Labarraque's solution, the following ready methods maybe resorted to for generating it : Quick Method.— Pom diluted hydrochloric, sulphuric, nitric, or acetic acid upon cholride of lime, zinc, or soda. This may be done gradually by means of a glass or lead syphon, or by the capillary syphon of lanip-wiek, dropping the acid upon the chloride, if desirable to evolve the chlorine steadily for many hours. C lorine water may be readily prepared by mixing two tablespoonsiul of common salt in two teaspoonsful of red lead in a quart of w 7 ater, and add half a wine-glassful of sul- phuric acid. It will give off gas as needed. It must bo borne in mind that chlorine is irritating to the lungs. It is believed not to disinfect and destroy the cholera poison itself, but it arrests putrefaction and destroys man} 7- noxious gases. 5. Nitrous Acid G is. — This is prepared by putting a mixture of nitrate of potassa, (saltpetre,) and sulphuric acid in an iron or porcelain dish. It must not be breathed. 6. Coal Tar.— To be used in sinks, sewers, privies, and bed-pans, by directly applying it, and allowing it to be washed away. It serves an excellent purpose when painted frequently upon the interior walls or sides of stables, prison cells, privy vaults, etc. Carbolic acid is derived from coal- tar, and is more convenient for use in the sick room. Dilute it. 52 IIISTOTCY OF TTTE CHOLERA. 7. Bromine. — Is a powerful disinfectant ; to be employed by physicians. 8. PrrmangnnaU of Potassa.— -To be used as an imme- diate and most effective disinfectant. Dilute the saturated solution of this salt in from 10 to 500 parts of water, accord- ing to the requirements for the occasion. It is the neatest and most effectual of all the disinfecting fluids, and can be used in less quantities than most others. A few drops of the solution will instantly disinfect a quart of drinking water. 9. HeaL — Boiling water or steam to be employed in cleans- ing as the most certain means of disinfecting contaminated clothing, etc. 10. Charcoal. — As a disinfectant or deodorant for exten- sive use in masses of putrescent material, and for local puri- fication, fresh charcoal is of acknowledged value. The Brit- ish Sanitary Commission in the Crimea, ordered whole ship- loads of peat charcoal, which they used in the progress of their work of purification in the hospitals, barracks and camps in the East. A Report of that Commission states that " perhaps the best deodorizing compound was one used by the inspectors in all their works. It consisted of one part of peat charcoal, one part of quicklime, and four parts of sand or gravel " But it may properly be stated in this Report that charcoal does not seem to disinfect or destroy the cholera poison. The ships w r hich were employed in transporting charcoal from Constantinople to the Crimea were ravaged by cholera. The following advice concerning disinfection has recently been promulgated by order of the Privy Council of the Brit- ish Goverment : — u In the ordinary emptying of privies or cesspools, use may be made of perchloride of iron, or chloride of zinc, or of sulphate of iron. But where disease is present, it is best to use chloride of lime or Condy's fluid. Where it is desirable . to disinfect, before throwing away the evacuations from the bowels of persons suffering from certain diseases, the disin- fectant should be put into the night-stool or bed-pan when about to be used by the patient. " Heaps of manure or other filth, if it be impossible or HISTORY OF TIIE CHOLERA. 53 inexpedient to remove them, should be covered to the depths of two or three inches with a layer of freshly burnt vegeta- ble charcoal in powder. Freshly burnt lime may be used in the same way, but islesa effectual than charcoal. If neither .charcoal nor lime be at hand, the tilth should be covered with a layer some inches thick of clean dry earth. " Earth, near dwellings, if it has become offensive or foul by the soakage of decaying animal or vegetable matter, should be treated on the same plan. " Drains and ditches are bear treated with chloride of lime, or with. Condy's fluid," (permanganates,) "or with chloride of iron." " Linen and wearing apparel, requiring to be disinfected, should without delay be set to soak in water, containing per gallon, about an ounce either of chloride of lime or of Condy's red fluid. The latter, as not being corrosive, is preferable. Or the articles in question may be plunged at once into boiling water, and afterwards when at wash be actually boiled in the washing water. '• Woolens, bedding, or clothing which cannot be washed, may be disinfected by exposure for two or more hours in chambers constructed for the purpose to -a temperature of git) to 250. degrees Fahrenheit. '■For the disinfection of interiors of houses, the ceilings and walls should be washed with quicklime water. The wood-work should be well cleansed with soap and water, and subsequently washed with a solution of chloride" (per- manganates) "of lime, about two ounces to the gallon." In presenting these practical suggestions, it is not intended to unwarrantably exalt the value of disinfecting agents. With reference to the whole subject the remark adopted in a man- ual published by the U. S. Sanitary Commission: "That there is no substitute for fresh air to meet the physiological requirements of respiration and health, should be indelibly impressed upon every mind. Better that all substances at present employed as disinfectants and deodorants were at once prohibited, than that such agents should practically tend to be regarded as substitutes for a pure atmosphere. 54 HISTORY OF THE OHOLERA. PEEYENTIYE AGAINST CHOLERA. Much depends on each individual as lo the mole of life .adopted, during the Winter, as a preventive to cholera. In the first place, eat nothing but the most wholesome, digestible and nutritious food, avoiding everything liUely ^ to derange the bowels. Abstain from an excess of alcoholic drinks. It is a great popular error to suppose that drink- ing plenty of whisky or brandy is in auy way a preventive against epidemics, but more particularly cholera. Avoid excessive study or labor ; sleep in well-ventilated rooms and keep the house well ventilated and dry, and at a mod- erate temperature. Dress warmly, particularly about the abdomen. A very good plan is to wear flannel over the bowels. Abstain from excessive pleasure ; keep regular hours, retiring at a seasonable time. Take moderate out- door exercise, but regularly every day. Pay particular attention to water- close! s, and see that they are kept clean. Chloride of lime should be thrown into them once a week, and if in a boarding-house or very large family, where there are many using them, it should be used twice a week. Cathartics should be avoided as much as possible, as when the bowels are once deranged it is difficult to get them right again, more particulary when there is any epi- demic in the atmosphere. Water should be boiled and filtered, not through charcoal but through regular filtering- paper, which can be obtained from any druggist. By all means don't be induced to take the various patent medi- cines advertised as preventives and cures for cholera. Such is the well-founded assurance of personal security from cholera, when the principles of hygiene and the means of proper care are practically understood, that no physic 'ma of good judgment and intelligence fears to visit any city or place where cholera prevails, or to remain at his post of professional duly iu the midst of an epidemic of the disease, for he knows that the exciting causes of cholera are avoid- able, and that its premonitory stages can be very certainly arrested if the general health and personal habits are good. Nothing could better illustrate the value of proper atten- HISTORY OF THE CHOLERA.. 55 lion to personal health and daily habit-. In short, C oleva os a pestilence must be regarded as a preventable dise /se. THE CHOLERA CONFERENCE At Constantinople, Turkey, received recently from the French representatives the following proposals in regard to the stoppage of all sea communication between Arabia and Egypt in the event of another epidemic. 1. That the Ottoman Sanitary Commission, now in the H jaz, should report on the health of the pilgrims. 2. The presence of several vessels of war to interrupt mar- itime communication. > 3. An organized surveillance over the Egvptian coast to prevent any disembarkation in infringement of the pro- hibition. •The manner of carrying this plan into execution was set forth as follows : 1. In the event of cholera breaking out among the pil- grims, the members of the Ottoman Commission, assisted, if need be, by other medical men appointed ad Loc, shall re-' port the fact to the local authorities, and to the vessels of war stationed at Jiddah and Yembo, and shall also transmit the intelligence to Europe. 2. On the declaration of the said medical men, .the local authorities shall interdict, until further orders, all embark- ation, and shall mvite all pilgrims destined for Egypt to pro- ceed thither by land. 8. At the same time the vessel of war shall send away from the ports of embarkation all steamers and sailing ves- sels which may be found there, and shall exercise a strict surveillance in order to prevent any clandestine departure. 4. On advice being received of the presence of cholera* among the pilgrims, the Egyptian authorities shall forbid the entry of all arrivals from the Arabian xoast, commencing from a point to the south of Jiddah to be determined. Fur- ther, they shall assign to the suspected vessel, after re-vic- tualling them, in case of necessity, a locality on the coast of Arabia — Tor, for instance— where they shall perform quar- antine. 50 IIISTOTCY OF TITE CTTOLEEA. 5. With regard to the caravan, it must be stopped, as is usual, several days'- march from Suez, where it shall be vis- ited by a medical commission, and shall not be allowed to enter Egypt until its sanitary state is declared free from danger. 6. As respects the pilgrims destined for India or other countries beyond the Red Sea, it will be best, in' order to avoid the risk of a partial embarkation, to subject them to the same general rale, namely, to make them wait till tlie end of the interdiction. However, it may be possible to as- sign them a particular spot some day's journey to the south of Jiddah, where they may embark. 7. The prohibition to embark shall cease fifteen days after the last case of cholera declared in Hijaz. Objection was made to these requirements by the English, Russian, Turkish and Persian delegates, but there was a majority in favor of them, in spite of a declaration on the part of the Turkish government that it could not engage to carry out the scheme. At the last meeting, however, on the 3d instant, several modifications were made in the French proposals, owing to the strong objections urged by the En- glish delegates on behalf of the Indian pilgrims. By para- graph three, as it now stands, the t ships of war are to send away all steamers and sailing vessels from the ports of em- barkation only ; and paragraph six has been altered as fol- lows : " With regard to the pilgrims destined for India, or other countries beyond the Red Sea. it would be best to assign them a special point for embarkation several days' jnarch to the south of Jiddah. unless the authorities judge that they may be embarked without risk at Jiddah." DISINFECTANTS ON SHIPBOARD. The following is a new and improved method of fumisra- ting. and disinfecting vessels, which is thorough and reliable. The old plan of burning tar is not sufficient to destroy the infection of cholera: Large shallow pans are made of sheet- lead, by bending the edges upward, and numbers of them are placed on the floor and elsewhere in the hold, and state- HISTORY OF TTTE CHOLERA. 57 rooms, (if there be any,) and cabin. A layer of manganese is then spread in each, some two hundred or three hundred pounds being used for a single vessel.. The hatches, and all other openings to the outer air, are fixed ready to be closely battened down in a moment's- time. Then hydro- chloric acid is poured on the manganese, twenty or thirty carboys being necessary. This is done as rapidly as possi- ble, as the deadly gas begins to generate immediately, and • the operator hurries to the deck, the hatches are battened down, and he leaves the ship. All trunks, boxes, and chests are previously opened of course, so -that the gas can have free access. Chlorine forms in immense quantities and per- meates everything, perfectly neutralizing all infection, killing all insects and animal life, 'and deodorizing everything im- pure or diseased. If by any accident a fire should be burn- ing, the gas extinguishes it at once. The man who puts the acid on the manganese must not tarry, of course, or he would be killed by the gas m less than ten minutes. The vessel is thus left alone for some hours, after which the hatches are opened, ventilators put up, the gas blown out, and the ship is as pure as when first built. Of course, it is necessary, to transfer the passengers to some other vessel, or to land them while the process is going on. Moreover, before the whole vessel is fumigated, each passenger selects a suit of clothes from his wardrobe, tickets it, and these suits are hung up in a special room, which is closed and fumigated by the same process. Then the passengers bathe, and those with beards shave their faces, if they shave at all, and evacu- ate the bowels, dress rapidly in their purified clothes, and are immediately transferred to another ship. QUARANTINE. This word originates from the custom of keeping a vessel "with a contagious disease on board, at anchor for forty days off French ports, from the numeral quarante, signifying forty. EARLY TREATMENT. In 1854 certain towns in England were almost shielded from this dreaded enemy by preparing their sanitary de- 58 HTSTORY OF THE CHOLERA.. fences in lime. \Voreester, on the Severn, entirely escaped it. In this country it is recorded that in Philadelphia the most active measures were taken to guard the public health in the epidemic of IS ±9 ; 2,970 privies were cleaned ; 340 houses were cleaned by the authorities; 188 ponds drained , 66 rag and bone-shops closed, and in all, over 6. 000 'tis inc$ sources of disease removed. The consequence was that 'the number of deaths in that city was only 747, while in New York they amounted to 5,071! In Boston, good health arrangements kept the pestilence in the lowest and dirtiest streets, and reduced the deaths to some 633. In Baltimore very few deaths occurred. The great desideratum for the treatment of the disease is to meet it early. The danger with the premonitory symp- toms — the painless diarrhoea — is that nobody thinks any- thing of it. The poor are especially negligent of this warn- ing. One symptom of the disease is the indifference it in- spires. It is related that in the medical house-to-house visitations in Glasgow, before the cholera of 1854, out of 45,000 cases visited and treated, only fifty-two died ; so important is the. early treatment. The ratio of deaths'to cases increases almost geometrically, as time is suffered to elapse between the first symptom and medical treatment. And from repons of the General Board of Health of Lon- don, it appears that out of 30,000 cases treated early, of which 6,000 were developed cholera, only 280 went to the stale of collapse. This is the fact which justifies the ex- cellent plan already suggested — the house visitation and treatment. The great matter with the poor is to provide remedies quickly, and to lead them to guard immediately against the diarrhoea. For other persons, the medical act- vice is, as soon as \his forewarning symptom is perceived, that they should go directly home, with as little effort as may be, and at once place themselves in a reclining posture, and check the diarrhoea with any ordinary opiate or other medicine, till their medical adviser can be summoned. At this stage of the disease there is but little danger. The number of deaths to cases treated at this period are won- der fulLy small. HISTORY OF TIIE CHOLERA. 59 PERSONAL AVOIDANCE OF THE CHOLERA^ Dr. Stayers holds that if the people understood the single faet that cholera always is preceded by certain premonitory symptoms, such as lassitude, languor, debility, and a diarrhoea, and that in this stage of the disease it is nearly always curable, if the proper precautionary measures are taken, it would tend to allay the popular terror. At this stage of the disease, it is of the first importance to pay at- tention to the first symptom, which is diarrhoea. At the very first approach, the patient should assume a horizontal posture and retain it, with the hips higher than the shoul- ders, and under no circumstance assume the perpendicular, even for a moment. Absolute, positive rest is needed, the body being kept in a warm condition. Any artificial means can be used for that which may be necessary. The main thing is the horizontal position, and perfect rest at the very commencement of the disease. If the patient, is down stairs when taken, let him stay there or be carried up. If lie is out visiting, let him stay at his friend's house. Keep- ing this position for forty-eight hours, in the majority of instances, the disease wil! pass over, and the patient, on recovery, need make no very great changes in his mode of life. Of course, if he his bad habits, he should reform -them ; eat and drink rationally, and attend to business as usual, but not. overdo it. In the present state of the atmos- phere, when pestilence is abroad, the system is rendered morn liable to exhaustion, and he should husband his strength by avoiding violent exercise. VARIATIONS IN THE SYMPTOMS. The general features — what one may term the contour— of Cholera Asphyxia, that compendium of the prominent phenomena from which, in all latitudes, seasons, localities and classes, the disease may be easily and certainly made out, being sharply defined and uniform, the same symptoms, nevertheless, vary infinitely on the degree of their intensity, "according to circumstances" internal or external to the in- dividual — froin the simplest diarrhoea with little pain and no 60 HISTORY OF TITE CTIOLEIIA.. cramps, and no graver derangement of the circulation and temperature of the surface than occurs from the operation of an ordinary purgative, up to the overwhelming attack of a prostration so paralyzing that the person stricken has scarcely become sensible of pain when the secretions are suppressed and the heart's action sinks suddenly. Some- times the premonitory symptoms are protracted,' and the pa- tient has a week or more of warning, in the form of diarhoea, uneasiness, and a sense of heat and " thrill" in the stomach and bowels; in some cases, not diarrhoea, but obstinate cos- tireness, prevails. Sometimes he "falls dead in his tracks," like the men in the army of the Marquis of Hastings. At Bellamy, in India, a tailor was attacked while at work, and died in his working attitude, cross-legged on his mat ; and a merchant, concluding a bargain, vomited twice and instantly expired. At Mecca, individuals in perfect health were sud- denly stricken to the earth, vomited, . turned cold, and died. Betw r een these two extremes the merciful admonitions are of various duration, from. a few hours to a few days; in the large majority of cases the disease takes from six to twenty- four hours to fully develop itself, and terminates by death or convalescence in from one to two days from the inception Of collapse. Sometimes the patient sinks at once, after discharging a small quantity of colorless fluid by vomiting and stool; sometimes the vomiting and purging are preceded by the spasms. , Sometimes the matter vomited, instead of being colorless or whey-like, or like seething of oatmeal, is green, and the dejections instead of being thin, and whitish and muddy, are red and bloody, or they may even consist of a greenish pulp, like half-digested vegetables. We have described the cramps as usually beginning in the extremities, and thence creeping gradually to the trunk; but in some cases they are simultaneous in all ; and sometimes the order of succession is reversed, the abdomen being first affected, and then the hands and feet. Generally, neither the vomiting nor the purging are symptoms of long continuance ; either they are checked by art, or the enfeebled body is no I longer able to perform those violent motions — so that they, mSTORY OF ttik ottoleua. 61 together with the cramps, usually disappear some time be- fore deatli. After the first emptyings of the bowels, the stools have been observed to be yellowish, turbid, or frothy, like yeast, and though generally inodorous, they sometimes emit a rank, fleshy smell. The dejections are seldom attended with much griping, and sometimes they are effected without effort or uneasiness, though generally the calls are sudden and irresistible, and the discharges expelled with alarming force. Tenderness of the belly, on pressure, is not among the most common symptoms, nor are the vomiting and purg- ing by any means the most important or dangerous ; in a great number of fatal cases, they have not been profuse, and have ceased, even without remedies, early in the attack. The cramps sometimes precede the vomiting and purging ; but in the low and most dangerous form of cholera, spasm is often absent, or is present in a very slight degree. Tetanic spasms of the legs, thighs and loins, have been observed, but there is no general tetanus (lock-jaw), or even trismus. Hiccough in cholera is not indicative of danger ; on the contrary, when it occurs in the interval of struggle between death and reac- tion, it is a favorable sign, and generally announces the re-, turn of circulation. The spasm at the pit of the stomach is often very acute, and the belly is almost always drawn to- ward the spine by a remarkable, permanent contraction of the abdominal muscles. The pulse occasionally, though rarely, keeps up tolerably. for several hours after the disease has plainly declared itself. Generally, it becomes small and ac- celerated at an earbf stage, and on the accession of spasm or vomiting, suddenly disappears from the extremities. On the cessation of the vomiting or spasm, and sometimes, appa- rently, from the exhibition of remedies, the pulse will return to the extremities- for a short time, and then again be lost. In the less severe cases it is not wholly extinguished, though much reduced In volume, and a thread of pulse, however small, is almost always felt at the wrist, where recovery from the blue or cold stage is to be expected. The sinking of the pulse in cholera is a symptom not less characteristic than the cadaverous countenanqe, or the hoarse, plaintive whisper (vox choltrica), or the discolored skin, or the chilled faeath ; 62 IIISTORY OF THE CnOLKP.A.. when it can be felt, it is generally regular and extremely feeble, " sometimes soft, not very quick, usually ranging from 80 to 100." In the state of the skin, as in the other symptoms of chol- era, striking variations are found. The surface is sometimes observed to be dry, though cold ; and in a few rare cases, natural — " nay, of preternatural warmth.' 1 A rise of temper- ature has been repeatedly observed to take place just before death ; but the development of heat under such circum- stances appear to be confined to the trunk and head, and in almost all cases may be regarded as a fatal symptom. It is • not indicative of any restoration of the diffused energy of the arterial system, or of any improvement in the function of respiration. The heat, in such instances, has continued veil marked for some hours after death. The . skin, in complete collapse, is generally insensible even to the action of chemi- cal agents, and hence the usual vesicatories fail to blister. The application of mineral acids, or of boiling water, in this condition *of the skin, produces little or no effect, and now and then a patient is found who is insensible to the opera- tion ; nor can leeches draw blood from an early peried of the attack. The blueness, so characteristic of cholera in the East, has by no means been found an invariable, or even a very common phenomenon in England or the United States. Dr. White, one of the physicians to the Gateshead Dispen- sary and Cholera Hospital, states that in scarcely one case in ten, in his practice, did the discoloration assume that form ; but there is often a deep, brownish hue of the face and hands. This blueness, or brownness, can often be temporarily dissipated by energetic friction. Absence of the peculiar " cold sweat" is a rare, and, we believe, a decidedly nn favor- able sign. . The urine, from having been limpid and free, will become more and more scanty, and its passage will sometimes be at- tended with such difficulty as almost to amount to stranguary ; but as the collapse advances, this condition gives place to that in which the kidneys have ceased to perform their of- fice, and there is no more secretion. Some patients complain of an urgent and painful desire to empty the bladder; but HISTORY OF THE CHOLERA. 63 the bladder is already empty, and, after death, is found to be dwindled to the smallest size; the desire may arise from the contraction of the posterior disk of the bladder hard against the internal meatus, as disclosed in post-mortem exami- nations. The pains of cholera are agonizing to the sufferer, and at times so pitiful as to move the attendants to tears. The pa- tient tosses incessantly from side to side, and complains of intolerable weight and anguish at his heart. Ashe struggles for breath, his imploring looks and gestures make you almost feel the horror that is burning and gnawing, and wrenching and strangling at his stomach and chest. At times, especially when the cramps are most severe, he rolls about and screams — and then there is that weary, weary cry for " water, w 7 ater, water," and that heart-rending, haunting wail, when the cold, bony grip of death is on him. Violent headache is far from being a common symptom in cholera — a neuralgic pain over one eye is less rare. The cramp is invariably increased on moving. In some cases the patient declares himself free from pain and uneasiness, just when the dead-cold skin and the sharpened, anxious features, and the absence of pulse at the wrist, most surely portend speedy dissolution. During all this mortal struggle and commotion in the hody the mind remains clear and the perceptions unimpaired, almost to the final moment of existence. "The patient, though sunk and overwhelmed, listless, averse to speak, and impatient of disturbance, still retains the power of thinking and of expressing his thoughts, so long as his organs are obedient to his will." Dr. Lawrie, Professor of Surgery in the Andersonian University, who closely observed the epi- demic as it appeared' at Sunderland, Newcastle and Gates- head, in 1832, commenting upon the declaration of the ma- jority of medical men, that the mind is always unimpaired, says it appeared to him-,, in many cases, affected Jo a degree little short ot what we find in concussion of the brain. He remarked this particularly in several children • when undis- turbed they lay in a dull, sleepy, semi-comatose state, breath- ing with perfect calmness ; when roused, they thought only 64 IIISTORY OF TIFE CHOLERA. of relieving their distressing sensations, and called vocifer- ously for cold water. But he does not say that he found them irrational or incoherent, or their condition was other than that which should attend upon congestion of the vessels of the brain. TIIE EUROPEAN AND EAST INDIAN FORMS. The points of difference between the phenomena of the European and the Indian forms of the Epidemic were intelli- gently stated by Drs. Russell and Barry, in a joint report to the British Government, dated " St. Petersburg, July *27, 1831," and by Dr. Lawrie of Sunderland and Newcastle, in a communication to The Medico- Chirurgical Review, in 1802 : 1. — "The premonitory stage occurs in a much larger pro- portion of cases in the English than in the Indian disease. In the latter it is the exception, in the former the general rule. 1 ' 2. — "The evacuations, both upward and downward, seem to have been much more profuse and ungovernable in the Indian than in the European cholera, though the character- istic of the evacuations are precisely the same." 3. — " Restoration to health from the cold stage, without passing through consecutive fever of any kind, is far more frequent in India than in Russia or England, nor does the fe- ver in India assume a typhoid type." [Recovery directly from the cold stage, without the fever, is the rule in India ; whereas, in England or in the United States, we believe that •few who once have been fairly collapsed, will escape the consecutive fever.] 4. — " The proportion of deaths in the cold stage, compared with those in the hot, is far greater in India than in Western Europe." o. — " The head is more frequently affected in the British than in the Indian form of cholera — as shown by great men- tal oppression and insensibility dnring collapse." . 6. — According to Dr. Lawrie, "the discoloration of the surface is neither so frequent nor so extensive in India as in England." [The blue is the common discoloration in India TTTSTORY OF THE CTTOT/ERA. 65 the brown in Europe ■ though in many cases in both England and this country, there has been a well-marked -purplish change.] THE EUROPEAN FORM NOT "SUDDEN." M. Guerin, a celebrated French physician, in an exhaustive report submitted to the French Academy, says that "before the epidemic of cholera which ravaged Europe in 1832, it was generally admitted that this terrible scourge attacked its victitmMn the most sudden manner, and struck them down with a degree of violence that was only comparable to the effects of a lightning-stroke. All the writings of this period take up this view of the disease. * Meanwhile, at the com- meneemsHi; of the epidemic of 1832, I perceived that it was quite otherwise. About a week after the appearance of the disease I wrote in the following terms to the Gazette. Medic ah : " '-Most of the patients attacked with cholera have been for several days, or even weeks, laboring under a disturbed con- dition of the digestive organs, wmich did not appear suffi- ciently serious to them to deserve careful attention ; such even have been their carelessness on this point that we have often been obliged to question them very closely in order to elicit information from them. It is only after having been asked three or four times whether they have had diarrhoea that they give a satisfactory reply. From this we conclude, (1.) That in many cases where. this diarrhoea has not been noticed there is reason to suspect carelessness in observation on the part of the patient. (2.) That this diarrhoea, the pTe- cursor of cholera, should receive the careful attention of medical men, parents, and even of the authorities, who should recommend to the poorer classes — and publish the recommendations by all the means at their disposal — to pay proper attention to this state of the digestive system, and should make known to them the fatal consequences of neglecting to treat, the diarrhoeal attack.' This opinion, winch had its origin In facts, was developed and confirmed by them. In proportion as the patients crowded into the wards of the Hotel Dieu, where I especially carried on my 60 niSTORY OF TITE CETOLEP.A. observations, my convictions became more and more strengthened. Out of 600 patients* questioned in the most careful manner, 5i0 had shown symptoms of tholerine (premonitory diarrhoea) before their entry into the hospital. From this I concluded, on the 12th of April : 1. "That cholera is always preceded and announced by a series of symptoms, to which, with a desire to caution the public, I have given the name of cholerine. 2. u That cholerine is the first stage of cholera. 3. " That cholera, properly so called, is only an atbranced stage of the disease which has hitherto been unknown in its first or premonitory period. 4. " That it is always possible to arrest the development of the mortal stage of cholera by attacking the disease in its curable one> "The existence of a prodromic or premonitory period in cholera is certain. The truth was accepted and admitted at the period of its announcement by the majority of physi- cians. The exceptions have hardly an existence, and are more apparent than real, being clue to the absence of powen of careful observation on the part of the patients. " Since 1832 there have been at short intervals three new epidemics of cholera. Moreover, this dreadful malady haj spread during the same period, or successively, cxrer the various countries of Europe and Asia. Has it in every in- stance conformed to the laws of its first evolution ? Haa the prodromic or premonitory period always prceded the mortal stage of this disease •? It is of the highest importance that the reply to these questions should be in the affirma- tive. For if this view — regarding it in its origin as one of the conquests of science and a benefit to humaity — receives from all recorded observation thS character of an unim- peachable truth, it is essential that it be published in all populations and countries, as affording a sheet-anchor (una ancre de salet) in the perils which menace human beings. Now, having been requested by the Academy of Medicine to superintend the general report upon the epidemics ol chol- era, I have been placed in possession of all the scientific documents, home and foreign, relating to the subject. IIISTOTCY OF TUB CITOLTCEA.. 67 "The result of an examination of these I have the honor to communicate to the Academy. Commencing with En- gland, we find the following remarks in the report of the * General Board of Health,' published in 1850 : ' Whatever doubts there may have been during the epidemic of 1832' as •to the existence of prodromic symptoms (diarrhoea), the ex- perience of the last epidemic solves the question completely. In one hospital where the first symptoms were minutely in- quired into, it was found that of five hundred patients al-. most all, without exception, had been previously attacked # bv choleraic diarrhoea, often or twelve days' duration. Dr. Burrows states that the replies- of the patients showed that the ' rice-water' discharge of cholera was always preceded by others of a different, though unhealthy character. Dr. M'Loughlin states: ' 1 believe I am correct in concluding, that of 3,902 cases of cholera, I have not found, one without prodromic diarrhoea.' , " In France there are the same confirmations as in En- gland. M. M. Levy found that of 142 patients, (at the hos- pital of Val-de-Grac,) there were only six without prodro- mic symptoms. In 95 cases the diarrhoea had lasted for two two, three, four, and even a greater number of days. A general inquiry, instituted by the ' Comite Consulatif d' Hy- giene,' during the epidemic of 1853, gives the following as' part of its report : ' From the 1st of November, 1853, to the 22d of January, 1854, of 974 choleraic patients admitted to the hospitals of the capital, 740 had been attacked with pre- monitary diarrhoea; the others appeared exempt, or were unable to give exact evidence.' To these authentic state- ments I may add those which have been made by the differ- ent departments of France in reply to the questions of the authorities. Almost ail the local physicians answer that cholera commences in the great majority of cases by diarr- hoea and other premonitory symptoms. The cases of sudden cholera, if they really exist, do not exceed five or six per cent." HELPS AND HINTS TOWAEDS A PATHOLOGICAL DEFINITION. The consecutive fever of cholera is not an integrant and necessary part of the disease. It cannot be distinguished 68 niSTOTCY OF TFTE CHOLETU. from an ordinary continued fever, except by the rapidity and fatality of its course. It is the result of nature's effort to re- cover herself from the stunning shock that has prostrated her, and the oppression that keeps her down. Cholera is only cognizable nith certainty during the cold or "blue" period ; of the three stages, the collapse alone is true chol- ■ era. Where medical measures have been promptly, energe- tically and successfully employed, the essential and diagnos- tic symptom, sudden sinking of the circulation, has often not developed itself ; and there are cases where an excited vas- cular action has accompanied the first tumult of the system in cholera. These are precisely the cases which yield most certainly and promptly to the remedial measures. In India it has been observed that these favorably indications chiefly appear among the European soldiers, who usually imbibe spirits freely at the commencement of the attack. During an invasion of cholera in Malacca and Burmah, in June and July, 1852, the writer of this had medical charge of an East India Companj^s war steamer in the Bay of Bengal and the Straits of Malacca. The ship's company was composed of Europeans and natives— Malays and Mohammedans— in about equal proportion. Under the peculiar treatment, to be described further on, not a single case of collapse occurred among the Europeans, all of whom "indulged" liberally, the officers in wine and toddy, the men in their regular grog, twice or three times a day, and in irregular "drinks" as often as they could get them ; whereas, among the natives, most of whom were abstemious, by reason of "piety" or vows, every case w r as collapsed; but the recoveries, even from the cold stage, amounted to eighty per cent. If the superficial veins and arteries be opened in the cold stage, the contained blood may flow out ; but their walls then collapse, and no more blood can be drawn. There is no authentic fatal case of cholera on record where the circulation has not been arrested, in the extremities at least, long before death. An increase of temperature is often observed, just before dissolution; but the development of Heat in such instances is [mrlia% being confined to the trunk and head, and is a niSTORY OF THE CnOLERA. 69 fatal symptom. This mocking warmth is generally appre- ciable for some hours after death. The application of boil- ing water to the skin, in the worst cases of collapse, pro- duces little or no effect, and some patients are insensible to the operation ; but it is certain that in a body but just dead of some other disease, boiling water will visieate readily. So extreme is the diminution, or so complete the destruction of the nervous energy of the skin, in the cold collapse of chol- era, that there is less vitality there in such eases, the patient being still alive, than in the skin of a body recently dead of a dif> rent disease. An Eastern physician states that he has applied boiling water to the feet and lips of patients in India, without eliciting a tone or gesture of complaint. The change in the condition of the. blood — ' : dark, black or tarry; thick, ropy or sirupy — is fully proved to be in the ratio of the duration pf the disease, the blood more or less rapidly changing from a natural to a morbid state, as the disease advances : such, is the general rule. Observe, that the blood is usually found to be less changed in those cases of cholera which are ushered in with pxcitemeiif, than where collapse has occurred at an early period of the attack. The blood is sometimes found, on dissection, to be of as dark a color in the left as in the right side of the heart — affording reason to believe that in the whole arterial system it is. equally changed. In many cases the temporal artery has been opened, after attempts to procure blood from the brachial or jugular veins had failed, and the blood in the artery was found dark and thick, like the venous blood ; it flowed in a languid, ropy stream, and then the artery col- lapsed. Hiccough is a favorable sign, and seems to announce the return of circulation, especially when it occurs in the inter- mediate moments between the threatening of death and the beginning of reaction. While burning thirst, pain at the stomach, cramps, asphyxia, clammy sweat, cadaverous edldness, and aphonia, may all be present, vomiting and purging may be absent, aad "yet ' the case will rapidly run to a fatal termination. The fact is, the vomiting and purging axe not only t; tar Irom 70 HISTORY OF TIIB CHOLERA." being the most important or dangerous symptoms " — it is not only true that " the clanger of the ease is by no means de- pendent on the quantity of matter discharged from the stomach and bowels," and that " in some of the worst cases this is not very considerable, and in some of the most success- ful it is very great " — but it is our conviction that the vomit- ing and purging are, in their original intention, genuine efforts of nature to relieve the engorged vessels and restore the -equilibrium of the circulation; that they constitute nature's safety-valve to the congestion ; that their presence, in coHrpse, is generally a favorable, and their sudden disap- pearance, a very unfavorable sign. 'They almost invariably cease a short time before death in the cold stage ; they fre- quently return in a notable degree at the beginning of reac- tion. Mr. John Fyfe of Newcastle, England, attended 579 cases of cholera ; and in all these, he says, collapse never came on " until after profuse serious discharges from the bowels." Was not nature, by those discharges, struggling to prevent the collapse ? — in the language of Dr. James Johnson, Physician Extraordinary to the King of England, was she not making "violent, but too often unsuccessful, efforts to restore the broken balance of the circulation, and to re-establish the secretions, by sickness and purging — the ejected fluids being rxudatv>n<, not secretions ?" Here nature cries to us for help, and shows us ho>c to help her — disclos- ing to us the inner mystery of cholera. * If we do not make haste to aid her in the direction she points out, she will ex- haust herself by her own tremendous efforts. In cholera there is every reason to believe that every species of secretion, in all parts of the body, is abolished. No known functions of the mucous membrane of the alimen- tary canal could form matter like that which is discharged ; and as there is no circulation going on in the skin, but rather a complete. state of asphyxia there, there can be no secretion of perspiration. The "cold sweat" of collapse is licit true perspiration (like the critical perspiration of the consecutive feve:'), but exudation ; and. viewing the skin and the mucous membrane as one continuous surface, it is just to conclude that this exudation is homogeneous throughout. " Whence, HI6T0BT OF THE CHOLERA. 71 then, and how, come these discharges ? Qn the skin, certainly not from circulation, for there is none there ; and it is more than probable that the capillary circulation of the mucuous membrane of the intestines is equally absent. It would seem as if the elements of the body, composing the parts nearest to the surfaces, became subject to new affinities, forming a new substance, incapable of being retained by the mem- branes, but rapidly oozing through them. Two facts go to support such an hypothesis : First, the abundant new forma- tion transuded, where no circulation exists ; and second, the rapid amaigrissement of the body. This wasting of the body is not merely apparent, it is real; the usual roundness of the parts is taken off, and tendons and other salient points become strikingly prominent. Of the two great classes of functions performed by the or- gans of which man is composed, one only is primarily para- lyzed by the poison of cholera. The operations of the senses, and of the intelligence, are either left untouched or are affected but in a secondary manner. It is the animal that dies ; the Intelligence, awe-stricken, surveys the scene of death, and trembles and wonders. These functions by which mere exis- tence is preserved — those complicated powers by means of which we are forever appropriating, and converting into a part of ourselves, portions of the matter around us — are, all at once and all together, deranged and disabled by the blow of this terrible angel. Nutrition is annihilated ; respiration becomes difficult, irregular, and inefficient, the involuntary muscles no longer perform their offices ; the voluntary are contracted in painful knots by other powers than the will ; the blood ceases to circulate; its physical properties are altered, its serous element suddenly thrown out upon the in- testinal mucous surface of the body ; the secretions are all arrested, and animal heat is no longer produced. The victim of cholera does not die " solely of starvation, caused by vomiting and diarrhoea," as certain doctors hold; but by paralysis of the nervous system and consequent chem- ical and organical decomposition of the blood. During the prevalence of cholera, there are observed among persons otherwise healthy, various anomalous affections of the nerv- 7a HISTOBT OF THE OHOLEB4L ous system — such as cramps, cold sensations of the hands, feet and legs, a peculiar thrilling in the extremities of the fingers and toes, and an oppressive feeling of anxiety in the region of the heart. After the first, or premonitory stage of cholera, bile ceased to be formed. We always find the gall- bladder full ; but this filling has taken place before collapse set in. There are no signs of bilious absorption. Adult age exhibits a much more lively susceptibility to the cholera poison than early life ; great numbers of children escape it, simply because they are less subject to the predisposing influence of fear. The idea of Bleeding in the stage of collapse, has its origin in an hydraulic theory totally inadmissable in cholera. There is not too much blood in the whole body, but too much at the centers and too little at the surfaces. A return to healthy distribution and eireulation will not result from abstracting, any more than from adding, a portion of the dammed-up mass. The cessation of arterial action is not owing to the state of the fluids, but to determinate derangement in the nervous power by which the machinery of circulation has been stopped. Besides, in most eases you cannot bleed ; thickened and stagnant in the vessels, the blood cannot be made to flow; and if a few ounces be squeezed from the orifices it hangs from them in long, tarry strings — to no pur- pose. The experiment of Galvanizing is a kindred absurdity. The desideratum in cholera is not the sujyph./ or restoration of vital or nervous power, but the propulsion of that power to the surfaces from which it has receded. THE FEVER STATE. A patient, having once fairly entered the stage of collapse, is rarely restored to health without passing through a fever closely resmbling the typhus miliar of Great Britain. The system, under the influence of the peculiar and mysterious poison by means of which the Asiatic cholera does its work, has been sunk into the lowest state of human existence. Those vessels that had ceased to pulsate, and those muscular fibrils that had been for clays convulsed, contracted, and, aa HISTORY OF THB OHOLEIU. ft it were, knotted and twisted in spasm, cannot at onco resume their healthy action. The vix medicatrix naturce, in resum- ing its efforts, seems over-eager for the restoration of the functions, and consequently sets up an exaggerated and dan- gerous action in every artery. After the "blue" cold period has lasted from twelve to twenty-four, seldom to forty-eight hours, the vital powers begin to rally, the circulation and animal heat to be restored, the cramps to relax, and the vomiting and purging to diminish, if they have not already ceased. The warmth returns gradually, the pulse rises in strength and fullness, and then becomes sharp, and some- times hard. The patient now complains of headache, with ringing in the ears. The tongue becomes more loaded, red- der at the tip and edges, and dryer; thirst continues, but there is less nausea. High-colored urine is passed with pain, and in small quantities. The pupil is generally dilated, and soreness is felt on pressure over the liver, stomach and bow- els. The stools are no longer like water ; they first become brown and thin — then dark, or black, and pitchy; and for some days the bowels continue to discharge immense loads of vitiated bile. A profuse critical perspiration may appear on the second or third day, and leave the sufferer conva- lescent: but more frequently the quickness of pulse and heat and dryness of skin are aggravated, the tongue becomes deeply furred, brown and dry, and sometimes hard, the eyes suffused and drowsy ; there is a dull flush on the face, with stupor and heaviness. Commonly, at this time, there is low, muttering delirium, or other marked affections of the brain ; dark sordes collect on the lips and teeth, the patient is pale, squalid, and low, catches his breath, is extremely restless, and moans " solemnly." The pulse becomes weak and trem- ulous, on the skin rigors alternate with flushes of heat. Then comes a blessed insensibility, and the patient soon sinks un- der the prostrating effects of frequent pitchy alvine dis- charges—death arriving on the sixth, eighth, or tenth day, or even later, to the very individual whom the most assidu- ous attentions had barely saved in the cold stage. Constipa- tion is not an uncommon symptom in the febrile stage, and the urine is often secreted abundantly— -in fact, dangerous 1A 1T13T0RY OF TAB CHOLBISA. retentions are to be guarded against. It is probable that the duration of the consecutive fever is, in the majority of Eu- ropean cases, commensurate with the duration and severity of the collapse, and not materially dependent on the kind of remedies employed. But, sometimes a very mild case pre- cedes a dangerous fever, especially in Europe ; and some- times after the severest collapse there is no fever at all, es- pecially in India. In Western Europe the consecutive fevei has been regarded as more frequently fatal, unless strictly vratched, than collapse itself; and in cases of recovery from even mild forms of fever, relapses, more or less alarming, have not been very uncommon there. PASSING FEOM THE STATE OF COLLAPSE. When the more formidable symptoms of collapse have set in with severity, the chances of recovery are in all cases pre- carious; and it the constitution has been impaired by pre- vious disease, or has failed by reason of age, the case has always been regarded as nearly hopeless. But in childhood, youth, and vigor of life, a well-instructed, sagacious and per- severing use of remedies will often be rewarded with com- plete success. A thread of pulse, however small, is almost always felt at the wrist where recovery from the " blue " or cold stages is to he expected. In such less formidable cases, it is never wholly extinguished,- though much reduced in volume; the respiration, too, is less embarrassed, and the oppression and anguish at the chest are not so overwhelm- ing, although vomiting, purging and cramps may have been more intense. Just where the favorable turn is taken, in the first feeble efforts at reaction, the return of circulation is often curiously announced by hiccough. Then the surface begins to grow warm, the pulse reappears at the wrist, and increases in strength and volume, and the natural hue of the skin is restored. Next, the vomiting and purging cease, or rapidly diminish — (in certain cases of recovery from extreme collapse they even return for a time, after having quite dis- appeared) — the cramps are relaxed, fcecal matters reappears in the stools ; bile, urine, and saliva are once more secreted and discharged ; the voice becomes stronger and more natu- ■ OTSTOItY OF THE CHOLKV.A. 75 ral— the racked and broken wretch sighs, weeps, and lives. When the vital forces have begun to rally, the physician cannot be too vigilant : he must watch nature warily, suspi- ciously, and prevent recurrence of collapse on the one hand, to repel congestions on the head and viscera on the other. Where the strength of the patient's constitution, or the cura- tive means employed, are, although inadequate wholly to subdue the disease, sufficient to resist the violence of its onset, nature makes various efforts to rally, and holds out strong but fallacious promises of returning health. Or when the restorative efforts are opposed by previous organic dis- ease, general feebleness of constitution, or the worn out ener- gies of age, we must not calculate too confidently on any imperfect reaction that may be induced. In all such cases, the lost heat may be wholly or partially restored ; if only partially, the chest and abdomen will become warm whil8 the limbs remain deadly cold — a most evil omen ; the pulse may return, growing moderate and full ; the vomiting and cramps may cease ; the stools may become green, pitchy, and even feculent ; there may be a partial restoration of the na- tural excretions — and yet the patient will suddenly relapse and sink, not from violent reaction or the development of any local inflammation, but from want of energy in the vital powers to carry forward the attempts at restoration which seemed so happily begun. The sufferer may have fallen into a flattering slumber; but now anxiety and sleeplessness will return, and all the alarming symptoms be re-established. These ignus-fatui of rallying sometimes flicker for two or three days, and all that time life and death will be poised in a sensitive balance. In some of the most rapidly fatal cases warmth has partially returned to the surface, and the pulse has fluttered and flattered immediately before death. Be it remembered that the real danger is by no means in propor- tion to the quantity of matter discharged from the stomach and bowels. In some of the most trying cases this is not very considerable, and in some of the most successful it has been very great. Neither is cramp nor spasm a sure cri- terion. The great danger arises from suspended or imperfect 76 HISTORY OF THE CHOLEBA. circulation. Restore and equalize this, and you have " cured the cholera." THE D^AD. It used to be believed, rather fancifully, that the bodies of those who died of cholera underwent putrefaction sooner than those of persons dying under the ordinary circumstan- ces of mortality. There is no evidence of any such tendency to rapid decomposition, and people should beware of the no- tion. In some instances, the body — at least the trunk and head — has remained sensibly warm for some hours after death ; and spasmodic twitchings of the muscles have taken place and continued for some time, in the corpse. Dr. Law- rie observed that convulsive movements were common after mental life was quite extinct ; and that it was almost impossible to say " at what moment the vital motions ceased to vibrate." A body lies apparently lifeless, suddenly a convulsive shud- der shakes it ; its hands are clenched ; if you insert your own within them, and force them open, they shut again with a spasmodic catch. Thus, those who clung to the notion that rapid decomposition is peculiar to death by cholera, are apt to bury with indecent haste; while those, on the other hand, who are ignorant and superstitious in regard to the fallacious warmth and the convulsive movements, are loth to inter until the remains have actually begun to putrify. On the 24th of July, 1832, the Special Medical Council of the New York Board of Health, presented a report in relation to the unnecessary haste with which the bodies of persons who had died of cholera had, in some instances, been interred : "The Council," they said, "are of opinion that the dead may, with perfect safety to the living, remain unburied at least six hours [why not twelve ?] even during the present warm season, and under proper precautions, for a much longer period. They also deem it expedient that the public should know that the neighborhood of the hospitals and burying-grounds has not been found, upon inquiry, to be pe- culiarly liable to the disease. At the public burying-ground, called the Potter's Field, where nearly 100 bodies have been buried daily, during the past week, none of those engaged HISTORY OF TIIB CHOLERA. 77 in the work have been taken ill ; and of the 100 persons liv- ing in the Asylum for the Deaf and Dumb, within 200 yards of the same, not one is known to have been attacked." APPEARANCES ON DISSECTION. The appearances disclosed on post-mortem inspections of the bodies of those who have died of cholera, vary according to the duration and intensity of the attack, the age, constitu- tion and previous health of the " subject," and the remedies administered; but enough of uniformity is found in the reports of the most instructed and careful observers — especially as to the points most significant, and of the first pathological importance — to serve the purpose of a description addressed to the unprofessional multitude. Enough, too, we think, to afford an accurate definition of the disease, in place of the bewildering guess-work of the text-books. In the language of the Medico- Chiru7\gical Review. " The man who would treat disease successfully, must not consider his only aim and object to be the knowledge of the various morbid changes which take place in the structure of the different organs, and of the symptoms by which they are distinguished ; his researches must be directed beyond this — to the laws of vital actions, to the manner in which they are disordered, and to these agents capable of restoring them to their healthy state." The bodies of those who have sunk in the earlier stages of cholera exhibit hardly any unhealthy appearance; the stomach and intestines are apt to be paler, and more dis- tended with air than usual, and some explorers have discov- ered, fancifully perhaps, a " characteristic foeter" from the abdominal cavity. But in the more protracted cases, a greater or less degree of injection of the mucous membrane, with occasional ccchymosis, is the most frequent appearance. It has also been observed, in erases where the violence of the spasms proved the most prominent symptom, that the mu- cous membrane presented that appearance which approaches nearest to inflammation. The large intestines are sometimes filled with whitish and flaky-turpid fluid, sometimes with greenish, yellow, or tarry matter— in other words with the 78 niSTORY OF THE CHOLKKA. characteristic discharges, or with vitiated bile, just as the patient may happen to have died in the earlier or later periods of the attack, in collapse or in the struggle for reac- tion. In like manner the stomach Contains either the injesta in an altered state, or the same " veal-soup-like" stuff that the patient has been vomiting ; or its contents may be green or dark. So, likewise, as to the vascular appearances pre- sented by the alimentary canal, the varieties seem to corres- pond, with instructive regularity, to the duration, the stage, and the intensity of the attack. The mucous membrane is generally somewhat softened; sometimes of an unnatural paleness throughout, " but oftener having various portions tinted of various hues," from the pale rose to the dark brick- dust and slate-colors, as venous or arterial injection predom- inates ; patches of ecchymosis and arborizations of the larger branches are frequent ; but the most common appearances have been a red or purplish speckling of the mucous mem- brane, generally over the whole surface, but more apparent in some parts than in others. Sometimes these different appearances are scattered throughout the entire extent of the alimentary canal ; at other times the stomach alone is colored and the intestines pale, or the stomach pale and different portions of the intestines darkly injected. The venous trunks of both stomach and intestines are generally found remarka- bly engorged. The rule, divested of its numerous excep- tions, or rather modifications, dependent upon circumstan- ces and conditions which the intelligent physician will not fail to take into the account of each individual case, is : Where the patient has not lingered, but succumbed early to a rapid attack— no striking vascular change, beyond general venus congestion, and turgidity of the prominent vessels. Where collapse, in its completest form has been develop- ed, repelling and damming the current of the blood — univer- sal dark engorgement, with deep discoloration of the internal surface of the stomach and intestines. Where the disease has been protracted, and has reached the stage of consecu- tive fever — every degree of arterial injection, in addition to the congestion, from the lightest blush to the angry flush of exaggerated action and incipient inflammation* These are HISTORY OF THE CHOLERA. 79 the keys of the stages, the mad malady rings many a change on them. The liver is commonly found enlarged and gorged with blood ; but not always. In some cases it is large, soft, and light-colored, and not very turgid ; in others, it is even col- lapsed and flaccid. The gall-bladder is, almost without ex- ception, full of green or black bile. The spleen and kidneys are not always surcharged with blood : quite frequently they present a perfectly natural and healthy appearance. The bladder is always empty and contracted. The lungs have often been found in a natural state, even in cases where there has been much oppression of respiration. Much more com- monly, however, they are either gorged with dark blood, so that they have lost their characteristic appearance and have rather assumed that of the liver or spleen, or they are re- markably collapsed, their bulk so much reduced that they lie in the hollow on each side of the spine, leaving the cavity of the thorax nearly empty. In the majority of cases, the heart and its larger vessels are distended with very dark blood. All the cavities of the heart are filled with a thick, blackish treacle, and blood so dark that, when extended on a white surface, it resembles in color the piece of the darkest cherry, is often found in the arch of the aorta, and m the other great arterial trunks. The principal venous vessels are usually found engorged — the most forcible injection could not have completely filled them — and the contained blood is black and sirupy. The vessels and membranes of the brain are frequently turgid with blood, particularly toward the base. A fluid is sometimes found effused into the convolutions in considerable quantity, with more or less serum in the lateral ventricles. The blood- vessels of the vertebral column and spinal cord may be no- ticeably congested, and in some cases there are marks of in- flammatory congestion in the larger nerves. But the cases in which the brain presents a natural appearance, and those in which the sinuses, and the veins leading to them, are stuffed with almost black blood, are of equally common oc- currence. The following, by Dr. Hamlin, condenses all that can be 80 niSTOHY OF THE CHOLERA. said on the subject. His statements are clear, and his ex- perience enables him to speak with confidence on the sub- ject : Dr. Hamlin, for many years a missionary of the American Board at Constantinople; has furnished to the Christian Mirror on account of his very successful treatment of the cholera in that city. His practice has extended through three visitations of this dreaded disease, in 1848, 1855, and 1865. The suggestions are so simple that we publish them, in the hope that they will do good, if the cholera should be- come prevalent in the United States : Dear Sir — The cholera, which has just left us after com- mitting fearful ravages, is making its way into Europe, and will probably cross the Atlantic before another summer has passed. Having been providentially compelled to have a good degree of practical acquaintance with it, and to see it in all its forms and stages during each of its invasions of • Constantinople, I wish to make to my friends in Maine some suggestions which may relieve anxiety, or be of practical use. 1. On the approach of cholera, every family should be prepared to treat it without waiting for a physician. It does its work so expeditiously that while you are waiting for the doctor it is done. 2. If you prepare for it, it will not come. I think there is no disease which may be avoided with so much certainty as the cholera. But providential circumstances, or the thought- less indiscretions of some member of a household, may in- vite the attack, and the challenge will never be refused. It will probably be made in the night ; your physician has been called in another direction, and you must treat the case yourself or it will be fatal. CAUSE AND SYMPTOMS. 3. Causes of Attack. — I have personally investigated at least a hundred cases, and not less than three-fourths could be traced directly to improper diet, or to intoxicating drinks, or to both united. Of the remainder, suppressed perspira- tion would comprise a large number. A strong, healthy, HISTORY OF THE CHOLERA. 81 temperate laboring man, had a severe attack of cholera, and after the danger had passed, I was curious to ascertain the cause. He had been cautious and prudent in his diet ; he used nothing intoxicating ; his residence was in a good lo- cality ; but after some hours of hard labor and very profuse perspiration, he had lain down to take his customary nap right against an open window, through which a very refresh' ing breeze ivas blowing. Another cause is drinking largely of cold water when hot and thirsty. Great fatigue, great anxiety, fright, fear, all figure among inciting causes. If one can avoid all these, he is as safe from the cholera as from being swept away by a comet. 4. Symptoms of an Attach. — While cholera is prevalent in a place, almost every one experiences more or less dis- turbance of digestion. It is doubtless in part imaginary. Every one notices the slightest variation of feeling, and this gives an importance to mere trifles. There are often a slight nausea or transient pains, or rumbling sounds, when no at- tack follows. No one is entirely free from these. But when diarrhoea commences, though painless and slight, it is in reality the skirmishing party of the advancing column. It will have at first no single character of Asiatic cholera. But do not be deceived. It is the cholera nevertheless. Wait a little, give it time to get hold, say to yourself, " I feel per- fectly well, it will soon pass off;'' and in a short time you will repent of your folly in vain. I have seen many a one commit suicide in this way. Sometimes, though rarely, the attack commences with vomiting. But in whatever way it commences, it is sure to hold on. In a very few hours the patient may sink into the collapse. The hands and feet become cold and purplish ; the countenance, at first nervous and anxious, becomes gloomy and pathetic, although a men- tal restlessness and raging thirst torment the sufferer while the powers of life are ebbing. The intellect remains clear, but all the social and moral feelings seem wonderfully to collapse with the physical powers. The patient knows he is to die, but cares not a snap about it. In some cases, though rarely, the diarrhcea continues for a day or two, and the foolish person keeps about, then suddenly sinks, sends 82 niSTORT OF THE CHOLERA. for the physician, and before he arrives " dies as the fool dieth." COURSE OF TREATMENT. 1. For Stopping the Incipient Diarrhoea. — The mixture which I used in 1848 with great success, and again in 1855, has during the epidemic been used by thousands, and although the attacks have been more sudden and violent, it has fully established its reputation for efficiency and perfect safety. It consists of equal parts, by measure, one of laudanum, one of spirits of camphor, two of tincture of rhubarb. Thirty drops for an adult, on a lump of sugar, will often check the diarrhoea. But to prevent its return care should always be taken to continue the medicine every four hours in diminish- ing doses ; twenty- five, twenty, fifteen, ten, nine, when care- ful diet is all that will be needed. In case the first dose does not stay the diarrhoea, continue to give it in increasing doses — thirty-five, forty, forty-five, sixty — at every move- ment of the bowels. Large doses will produce no injury while the diarrhoea lasts. When that is checked, then is the time tor caution. I have never seen a case of diarrhoea taken in season which was not thus controlled, but some cases of advanced diarrhoea, and especially of relapse, paid no heed to it whatever. As soon as this becomes apparent I have always resorted to this course : Prepare a teacup of starch boiled as for use in starching linen, and stir into it a full teaspoonful of laudanum for an injection. Give one- third at each movement of the bowels. In one desperate case, abandoned as hopeless by a physician, I could not stop the diarrhoea until the seventh injection, which contained nearly a teaspoonful of laudanum. The patient recovered, and is in perfect health. At the same time I use prepared chalk in ten grain doses, with a few drops of laudanum and camphor to each. But, whatever course is pursued, it must be followed up or the patient is lost. 2. Mustard Poultices. — These should be applied to the pit of the stomach, and kept on till the surface is well red- dened. 3. The patient, however well he may feel, should rigidly mSTOKT OF THJB CHOLEBA* $$ observe perfect rest. To lie quietly on the back is one-half of the battle. In that position the enemy fires oyer you, but the moment you rise you are hit. When attacks come in the form of a diarrhoea, these directions will enable every one to meet it successfully. 4. But when the attack is more violent, and there is vomit- ing, or vomiting and purging, perhaps also cramps and colic pains, the following mixture is far more effective, and should always be resorted to. The missionaries— Messrs. Long, Trowbridge, and Washburn— have used it in very many cases with wonderful success. It consists of equal parts of laudanum, tincture of capsicum, tincture of ginger, and tinc- ture of cardamom seeds. Dose, thirty to forty drops, or half a teaspoonful in a little wate/, and to be increased according to the urgency of the case. In case the first dose should be ejected, the second, which should stand ready, should be given immediately after the spasm of vomiting has ceased. During this late cholera siege no one of us failed of controlling the vomiting and also the purging by at most the third dose. We have, however, invariably made use of large mustard poultices of strong, pure mustard, applied to the stomach, bowels, calves of the legs, feet, etc. as the case seemed to require. TREATMENT OF COLLAPSE. Collapse, — This is simply a more advanced stage of the disease. It indicates the gradual falling of all the powers of life. It is difficult to say when a case has become hopeless. At a certain point the body of the patient begins to emit a peculiar odor, which I call the death odor, for when that has become decided and unmistakeable I have never known the patient to in §eover. I have repeatedly worked upon such cases for hours, with no permanent results. But the blue color, the cold extremities, the deeply-sunken eye, the van- ishing pulse, are no signs that the case is hopeless. Scores of such cases in the recent epidemic have recovered. In addition to the second mixture, brandy, (a tablespoonful, every half hour) bottles of hot water surrounding the patient, 84 HISTORY OF THB CHOLBBA. especially the extremities, sinapisms and friction, will often in an hour or two work wonders. Thirst.— In these, and in all advanced cases, thirst creates intense suffering. The sufferer craves water, and as sure as he gratifies the craving, the worst symptoms return, and he falls a victim to the transient gratification. The only saft way is to have a faithful friend and attendant who will not heed his entreaties. The suffering may be, however, safely alleviated and rendered endurable. Frequent gargling tfce throat, and washing out the mouth, will bring some relief. A spoonful of gum Arabic water, or of camomile tea, may frequently be given to wet the throat. Lyndenham's White Decoction may also be given, both as a beverage and nour- ishment, in small quantities, frequently. In a day or two the suffering from thirst will cease. In a large majority of cases it has not been intense for more than twenty-four hours. Diet. — Rice water, arrowroot, Lydenham's White Decoc- tion, crust water, camomile tea, are the best articles for a day or two after the attack is controlled. Camomile is very valuable in restoring the tone of the stomach. The Typhoid Fever.— A. typhoid state for a few days will follow all severe cases. There is nothing alarming in this. It has very rarely proved fatal. Patience and careful nursing will bring it all right. The greatest danger is from drinking too freely. When the patient seemed to be sinking, a little brandy and water, or arrowroot and brandy, have re- vived him. In this terrible visitation of the cholera we have considered ourselves perfectly armed and equipped, with a hand-bag containing mixture No, 1, mixture No. 2 (for vom- iting), etc., a few pounds of pounded mustard, a bottle of brandy, a paper of camomile flowers, and a r ^er of gum Arabic. ■** I lay no claim to originality in commending this course of treatment. I have adopted it from suggestions of able and experienced physicians. Having been the only doctor of many poor families living near me, I have tried various re- medies recommended by physicians, but I have found none to be at all compared with the above. During the recent HlflTORT OF THB CHOLKBA. &> cholera I cannot find that any treatment has been bo success* ful as this. Contagion. — The idea of contagion should be abandoned. All the missionaries who have been most with the malignant cases, day after day, are fully convinced of the non-conta- giousness of the cholera. The incipient attacks which all have suffered from are to be attributed to great fatigue, making the constitution liable to an attack. C. Hamlin. CHANCES OF AVOIDING THE CHOLEEA. A correspondent of the New York Express offers the following sensible and practical suggestions, tending to allay unreasonable apprehensions of danger from cholera in New York, and Brooklyn as well, which, as they are justified by the past and the present, will, we believe, be found to hold good in the future : In the first place,, it is said that New York is a very un- healthy city, especially at present. But the life-insurance men of the city tell us that they lose fewer lives here than elsewhere in proportion, while the agents of New Jersey, Connecticut, and Massachusetts say the same thing, and pre- fer making insurances here. These are certain tests, statisti- cal pecuniary facts that may give relief. The politicians may have made mistakes. In the next place, when the cholera previously visited the city a very small per cent, of the population, especially of the acclimated, cleanly-living population, were sick, and, of course, not anything like so large a per cent, died — less than one per cent. died. Again, it is the testimony of some of the best physicians in the city, and having the most extensive practice during and upon the chc J * Captir* Maiden. L*#«*dJo*. 9. Th*WU«T^ut of &* Mountains. II. Th* IS. Riekatty Tom. th* I?.- r« r tt. Th* tap* *f th* 1 I*. Th* I n. M. Liffhtfoot. tht Seoul IT. The Giant $vi of Bunk*r Hill. U. 8e*r4:h**k, th* Wild Ha2f-Br**d W 8qolnt-By*d 1 • SI. Snakr 8nod*Ta§*. tl. Battinff Thun4*r, *r ft* BiT*i War-! Oat**. i ■< : • C4 i . h* W*OdS. rh* On*-Kr*d Robb*r. H. Th<: *n#a It. Th* Old Scout *f th* C*t* 17. Bit Snake th* Huron. *T. M *iiean J**, th* Snaka'^^^^H r Hand, th* 9h*rp-Shoot Hv< w. Qip*r Jack, fl. Th* S**rl*t Warrior. CI. Th* Seont of Tippooanoa •fOmnf-Th* Ohott of W*!M«ftft. 30JVG &00JT8. 1. TtofcMte&Piurtf •*mtfB**k. 1 Th* Tank** SaQor 3*&* Book *= Th* Russian Boar and A»*r4eaa B*«t1* Son«B*ek. *. Th* Bum* and It****** Bon* Book. I. Th* Gre*l*7 and B*»n*tt tonf- Book. 8 Tho Jolly F*Uow'* Sons; Book. T. Paul Pry 8onfst*r Munre's Ton « ; - - Letter Writ**. Muuro f s Ton C*nt Cook Book Umax**! Baamtntary Fieneh dramaar- MVMRO'8 ITRBtfCH SJBltlJBS, JTO. /. Bain* an 51«i»*ntarr ©ramraar ti th • Franeh Lamrua*;*, by which *T*r]r on* oaa *trs* hi* own instructor. Th* tru* pronunciation of *Y*ry word in *a*h Le— on i* fi with it* aig i *rseu of *r*n th* most mod*rat* car*-, application. aid*d by this U \ , t* boeom* w*U * e ) u» i nted with the lan*;u \, a* f uch. eJ find it an in *«■■-., on. It is also spec:** s amvifnd *n an *a«r *nd protreeeiTO plan. In tact, d *** vek !.-..? 2*1 to the oapaeitie* of •▼*ry on* who d**ir*s to obtain a knowii «f ifc* Fr*neh L*a*~un*7* Pri*a 1 '* c Cant*. 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