LIBRARY OF CONGRESS. - PARTIAL SYLLABIC LISTS CLINICAL MORPHOLOGIES The Blood, Sputum, Feces, Skin, Urine, Vomitus, Foods, including Potable Waters, Ice and the Air, and the Clothing (After Salisbury), EPHJRAHVT CUTTER, M.D. Harvard and University of Pennsylvania, A.M. Yale, LL.D. Iowa, Hon. F.S.Sc. (London) Principal Medical Department, American Institute of Micrology; First to Photograph Consumptive Blood; Inventor Several Forms of the Clinical Microscope, The Cam Fine Adjustment, etc., etc. Corresponding Member Societe Beige de Microscopie and Gynecological Society of Boston ; Associate Member Philosophical Society of Great Britain; Honorary Member California State Medical Society; Member American Society of Microscopists, American Medical Association, etc. Author Boylston Prize Essay, 1857; Primer of the Clinical Microscope; What I Use the Microscope For; Morphology of Diseased Blood; Morphology of Rheumatic Blood (Ninth International Medical Congress); Morphology of Potatoes, Cooked; Crypta Syphilitica; Monstrous Spermatozoa; Micrographical Contribution as to the Vegetable Nature of Croup; Tubercle Parasite; Microscopical Examination of Ice; Suspicious Organisms in the Croton; Beri-Beri; Trichina; Butter; Effects of Alcohol on Brain Tissues; Action of Alcohol on the Blood; AsthmatosCiliaris; Diphtheria and Potatoes; Use of Microscope in Consumption; Throat Syphilis and Tubercle according to Salisbury; Tolles' 1-75 inch Objective, its History, Use, and Construction; Amoeboid Movements of the White Blood-Corpuscle; A New Sign of the Pre-Embolic State; Food Stuffs under the Microscope, etc., etc. u A capacity to do good not only gives a title to it. but makes the doing of it a duty." Duke of Brandenburg, 1691 NEW YORK THE ARISTON, BROADWAY AND 55TH STREET PUBLISHED BY THE AUTHOR I8S8 a«\? Copyright by EPHRAIM CUTTER, P«ES9 OF STETTINER, LAMBERT A CO, 22, 24 & 2t READE ST., NEW YORK. gexlicattou* This work is respectfully dedicated to the following, who have shown themselves searchers after medical truth and courteous to co-laborers. Benjamin Cutter, M.D., A.M., in memoriam, summa laude J. Marion Sims, M.D., LL.D., in memoriam, summa laude E. S. Gaillard, M.D., LL.D., in memoriam, summa laude Louis Elsberg, M.D., in memoriam, summa laude George Waterhouse Garland, M.D., in memoriam George M. Beard, M.D., in me- moriam, summa laude S. D. Gross, M.D., LL.D., D.C.L., in memoriam, summa laude Frank H. Hamilton, M.D.,LL.D., in memoriam, summa laude James R. Nichols, M.D., in memo- riam, summa laude Washington L. Atlee, M.D., in memoriam, summa laude Professor L. A. Sayre, M.D. Professor T. G. Thomas, M.D. Professor Albert Vander Veer, M.D., Ph.D. Professor R. J. Nunn, M.D. Professor T. E. Murrill, M.D. Professor T. E. Satterthwaite, M.D. Professor Joseph Jones, M.D. Professor Jacob Cooper, M.D., Ph.D., J. CD., S.T.D. Professor Wm. B.Atkinson, M.D., A.M. Professor Byron Stanton, M.D. Professor J. Solis Cohen, M.D. Professor W. W. Dawson, M.D. Professor Samuel B. Ward, M.D., Ph.D. Professor Joseph Leidy, M.D. Professor James P.. Boyd, M.D., M.A. Professor D. Hayes Agnew M.D. r LL.D. Professor D. Humphreys Storer, M.D., LL.D. Professor H. M. Field, M D Eugene Van Slyke, M.D. Israel H. Taylor, M.D. George D. Dowkontt, M.D. Ezra P. Allen, M.D., Ph.D. David Prince, M.D. Alfred C Garratt, M.D. G. L. Simmons, M.D. W. Symington Brown, M.D. Jonas C. Harris, M.D. Austin W. Thompson, M.D. Samuel W. Abbott, M.D., M.A. J. J. Mulheron, M.D. R. E. Thompson, M.D., F.R.C.P. Lond., summa laude Henry O. Marcy, M.D., LL.D. J. N. Hyde, M.D. Landon B. Edwards, M.D. Sir James Grant Professor Aust-Lawrence, M.D. D. H. Goodwillie, M.D. Professor A. B. Arnold, M.D. R. U. Piper, M.D. W. R. Weisager, M.D. Professor Domingos Freire, M.D. Caleb Green, M.D. A. F. Pattee, M.D. Fr. Ecklund, M.D. Professor E. A. Wood, M.D. Professor M. C. White, M.D. M. G. Wheeler, M.D. Henry C Bunce, M.D. Sir Morell Mackenzie IV DEDICATION. TO MY INSTRUCTORS James H. Salisbury, M.D., LL.D., Professor Oliver Wendell maxima laude Holmes, M.D., LL.D., D.C.L. Professor Paulus F. Reinsch Rev. Joseph Cook Professor J. P. Cooke, M.D. George B. Harriman, D.D.S. Robert B. Tolles, in memoriam INTRODUCTION TO THE MOR- PHOLOGIES. It is now over ten years since the writer first applied this word to the account (logos) of the forms (morphos) found in the blood, sputum, faeces, urine, etc., and its general adaptation seems to justify the use of the term. It was employed to facilitate the introduction of the thoughts and results embraced in The Relation of Alimentation to Disease* by J. H. Salisbury, M.D., LL.D., the master discoverer and ex- plorer. The morphologies of his discoveries are over twenty-five years old. The number of people who have been cured by the thorough and systemic plans based on them is such that there is no need of apologizing for bringing them more prominently to notice, but rather of apologizing that they have been kept back so long. The writer has not ceased night and day to urge their publication, and he is per- mitted to hint gently that, if what has now been issued is well received, much more valuable * New York: J. H. Vail & Co., 1888. VI INTRODUCTION TO THE MORPHOLOGIES. treasures will be dispensed from the store- house to all who ask for them. Those who gain a tolerable knowledge of these lists will expect, among other things, to diagnosticate consumption of the lungs in (i) The pretubercular state; (2) In the inva- sion stage ; (3) In the breaking down stage. To diagnosticate syphilis at once. To diag- nosticate rheumatism, in its various forms. To diagnosticate fibraemia, anaemia, leucocythaemia, malaria, diseases of fatty degeneration, scle- rosis, locomotor ataxy, impending apoplexy, and paraplegia, etc., etc. To diagnosticate a state of perfect health, a tendency to diseased conditions, etc., etc. Since nearly a quarter of a century has been spent on these morphologies, it cannot be claim- ed that they are hastily gotten up ; still the lists are all partial, subject to addition and subtrac- tion, as need requires. They may be taken to represent the actual state of knowledge at the present day, which is quite an advance over a quarter of a century ago. PREFACE. • For some years the writer has needed a pub- lished list of the clinical morphologies for the use of his pupils. He has waited long to have the lists complete, but in vain. Complete knowledge of any subject is about as rare as a completed city. Knowledge is ever on the increase, like most of our cities. We use our cities even if incomplete, so must we use our knowledge as far as it goes. One object of this work is to show the height and depth, the length and breadth of the so-called Salisbury plans; that they are en- titled, to respectful hearing ; that they include a wide survey and comprehensive grasp of the world that comes in contact with our bodies, outside and in ; that they have no narrowness of range nor contraction of vision ; that they deal with facts more than with opinions ; that the tests to which they may be subject are close at hand and near to reach. They are cis- not transatla?itic. These morphologies also show that the writer has not ridden a one-horse hobby in satisfying his mind of the truth of the plans named, but Vlll PREFACE. that he has endeavored to take broad views of all the evidence in the matter before coming to conclusions. It has been suggested that the writer give a short history of His relation to these subjects. In justice to all concerned, and to make shorter work, the personal pronoun will be used, mostly. I began the use of the microscope as a means of education and useful knowledge, if my mem- ory serves me rightly, in the Sheffield Scien- tific School of Yale College in 1850. The winter of 1853-4 I spent in Professor J. P. Cooke's private laboratory, working up the morphologies of blood and urine, together with their micro-chemistry. Besides him, I have studied under Dr. O. W. Holmes, Col. J. J. Woodward, G. B. Harriman, D.D.S., Pro- fessor Paulus F. Reinsch, the highest author- ity in algae; and Dr. James H. Salisbury. The last gentleman excels all others in the amount of original information which I have found of priceless need and value in medicine. Before studying medicine, I was inspired with a desire to know all I could about the causes of disease. Having, from a child, been in the habit of accompanying, in his professional rounds, my father, the late Dr. Benjamin Cut- ter, of Woburn, Mass. (w r ho honored his pro- fession for forty years), I early took in the idea that there was a great field of much-needed effort, from the chance remarks he would drop PREFACE. IX when he resumed his seat in the carriage (which I kept) after having seen some very sick patients. He said often, " Oh, how I wish we doctors knew more as to the real causes of disease." This impulse was much strength- ened by his telling me (when I informed him that I did not want to study medicine to prac- tice it, but only to know the causes of disease), " Go ahead ; study all you can. I will help all I can, but I want you to study these three things. " I. What is the cause of consumption. " 2. What is the cause of the diseases of women. "3. What is the cause of diseases of the nervous system. " We doctors do not know anything about them." And yet this was a surgeon who suc- cessfully, without anaesthesia, opened the knee joint and removed a free cartilage (assisted only by the writer when twelve years old). The present work is the outcome of this paternal injunction. Advisedly, seriously, and thoughtfully can it be now said, these three (3) problems have been answered satisfactorily, and we know that unhealthy alimentation causes primarily all of these classes of disease. In 1857, tri e Boylston Prize was awarded the writer for an essay on " Under what Cir- cumstances do the Usual Signs Furnished by PREFACE. Auscultation and Percussion Prove Falla- cious ? " In 1858, the writer invented a laryngoscope, which was made by Alvan Clarke & Son, the great telescope makers. In 1866, the writer took the first photograph of the vocal cords (his own), which showed the thyroid insertion. In 1866, he demonstrated to large numbers his own larynx in situ naturali, and the poste- rior nares, showing either Eustachian tubes at will, the vomer, and turbinated bones, and first demonstrated the erection of the mucous mem- brane of the turbinated bones in smelling odor- ous or malodorous substances. Before i860, he travelled over five thousand miles to see if alcoholism could be connected with consumption of the lungs. In 1867, I visited Dr. Salisbury to learn how to study malaria. At that time, I found he had gone one step farther than I, and connected the vinegar plant with consumption. Thus he sup- plied the missing link to my chain, and, after repeated and careful observations, I came to learn the truth of this new doctrine in the ac- tual treatment and cure of cases, and ever since have endeavored to make it known in proper ways, so far as I could. Finding Dr. S.'s drawings denounced and ridiculed, and, of course, rejected, and stung to think that this work should be deemed an idle PREFACE. XI tale, I set myself to work to photograph as many of the appearances in consumptive blood as I could. Probably this was the first attempt of this kind. Never before this had I known of any blood being photographed save for medico-legal purposes. I found the subject very much hampered with details which I thought should be done away with. Feeling the greatness of the work, and that it should be done before my eyesight and faculties were too old, I gave up a fine country practice and set- tled in Cambridge, Mass., as I thought this seat of learning would be the most favorable for the encouragement and prosecution of my work. The winter of 1875-6 was spent in working up micro-photography. Fortunately I came across Dr. G. B. Harriman, Surgeon-dentist, of Bos- ton, who possessed magnificent objectives made by R. B. Tolles, among them the 1-50 inch and 1-75 inch. He entered into the work heartily, and together we took micro-photographs of con- sumptive blood morphology for the first time and with the highest powers ever used up to that time and since (so far as I can ascertain), and which have been pronounced good in Europe. The account of this work may be found in the American Journal of Science, New Haven, August, 1879; Scientific American Stipple- ment, September, 1879; Journal of Micro- graphie, Paris, 1879. These photographs have been placed on the screen before the American XII PREFACE. Medical Association; Chicago Medical Society; Academy of Medicine, Virginia ; Academy of Sciences, New York; Albany Medical College; Monday Lectureship, Boston, Rev. Joseph Cook; Gynecological Society of Boston, and many other bodies. These things are named to show that I am in earnest, for none would have done this unless he was sincere and meant what he said. In 1876, Professor Paulus F. Reinsch was introduced to me at the Botanical Garden, in Cambridge, as the greatest algologist. Care- ful study with him has confirmed my views on these so-called Salisbury plans. So many cures have followed, that I feel it would be a crime in me not to testify to what I know, and how I have been set right upon the three tasks propounded by my honored and honorable fa- ther more than thirty years ago, and which, so far as in me lies, I have tried to solve or have solved. I am a co-witness with Dr. Salis- bury ; " that in the mouth of two or three witnes- ses every word may be established." I charge therefore those to whom these presents may come to look over the evidence, and take time before they treat these things as "idle tales." If the "Imperial Granum" which I have shown morphologically to be common flour, and which the Connecticut agricultural experiment sta- tion has also shown to be common flour, selling at $1.00 per pound, while it is worth from PREFACE. Xlll $0,025 to $0.05, is used amd indorsed by the medical profession (so that its proprietors have become rich and use fifty-two barrels of flour in one batch), on statements that wilt before the microscope and crucible, does it look well for the same noble profession to treat the plans here indorsed, which stand the tests of the mi- croscope and chemistry, as an " idle tale ? " I have nothing but good feeling or words towards those who honestly differ, but I do dislike to see physicians led by persons who not only have no medical education, but also ad- vertise untruths and at the same time consider these plans as "idle tales," and neglect to look into the evidence which has stood for nearly a quarter of a century, and which affects the weal or woe, not only of the public, but of the profes- sion and the very gentlemen themselves. Be this as it may, in time to come, none can accuse me of not having tried to discharge the duties which every physician owes to his fel- lows, to wit : if any physician knows or thinks he knows anything which will better the prac- tice of medicine, there is a moral obligation for him to discharge by making it known, and so long as the rules of courtesy are observed by the contributor, he is entitled to a courteous hearing. Any departure from this savors of savagery and puts the doer at once out of the pale of civilized ethics. May ist, 1888. CONTENTS. Dedication, ..... Introduction, . . . . . Preface, ..... I. The Morphology of the Blood — Mode of Study, A. General list of the Morphology of the Blood in Health and Disease, 3; The Colored Corpuscles, 3; The Colorless Corpuscles 4; The Serum, B. Morphology of the Blood in Health, C. Movements and Changes of the Blood in Dying, D. Morphology of the Blood in Consumption of the Lungs ; Use, 9 ; First or Incubative Stage 10 ; Second Stage, of Transmission, 10; the Third Stage or Stage of Tubercular Deposition 12 ; Fourth Stage, Interstitial Death, E. The Morphology of the Blood in Rheumatism, F. Fibraemia, .... G. Thrombosis, .... H. Embolism, .... I. Pre-embolic State, J. Anaemia, . K. Pernicious Anaemia, . L. Morphology of the Blood in Syphilis, M. Morphology of the Blood in Eczema, N. Morphology of the Blood in Scrofula, O. Morphology of the Blood in Malaria, P. Hereditary Taints, Q. Cancer, .... R. Morphology of the Blood in Variola and Vaccinia, S. Morphology of the Blood in Typhoid Fever, T. Morphology of the Blood in Scarlet Fever and Diph theria, ..... U. Morphology of the Blood in Fatty Degeneration, V. Morphology of the Blood in Fibrous Consumption, PAGET iii.-iv. v.-vi. vii.-xiii. 1 12 13 17 17 18 18 18 19 J 9 20 21 21 22 2 3 2 3 23 24 24 25 XVI CONTENTS. W. Cholestersemia, . . . . 25 X. Morphology of the Blood in Carbuncle, . 26 Y. Morphology of the Blood in Yellow Fever, . . .26 Z. Leucocythaemia, .... 26 II. Morphology of the Sputum, . . . 27 III. Morphology of the Feces, . . . '33 IV. Morphology of the Skin, . . . . 38 V." Morphology of the Urine, ... 43 VI. Morphology of the Vomitus, . . . .48 VII. Morphology of Foods, ... .49 A. Waters of Lakes, Ponds and Water sheds; Hydrant Waters, 49; List, 50; Appendix, . . 54 B. Waters of Springs and Wells unconnected with Lakes or Ponds, ..... 58 C. Ice, 63; List, 64; Appendix, . . . . 65 D. Air, 70; List, . . . . .72 E. Morphology of Foods; Animal and Vegetable, 74; Vegetable: Uncooked, 74; Cooked, 75; in the Feces, 75, 76, 77. Beefsteak: Uncooked, 76; Cooked, 76; in the Feces, 76; Adulteration, 77; Infants' Foods, ..... 78 VIII. Morphology of Clothing, ... .80 EXPLANATORY. Though, as stated in the title, these partial syllabic lists are after Salisbury, 1 wish to emphasize that those who read this book should, in order to get more information on the subjects noted, especially the blood, sputum, feces, urine, and skin, consult the works of Dr. Salisbury here named: i. " The Relation of Alimentation to Disease," octavo, pp. xi., 334, plates 19. New York, 1888: J. H. Vail & Co. (See " Clinical Morphologies," consumption of the lungs, pp. 9 to 13; fibrsemia, p. 17; anaemia, p. 18; perni- cious anaemia, p. 19; fibrous consumption, p. 25; sputum, pp. 27 to 32; feces, PP- 33 to 37.) 2. *' Microscopic Examinations of the Blood and Vegetations Found in Vari- ola. Vaccine, and Typhoid Fever.'* 66 pages and 62 illustrations. New York, 1868. (See page 23, " Clin. Morphologies.") 3. " Remarks on the Structure, Functions, and Classification of the Parent Gland Cells, with Microscopic Investigations Relative to the Causes of the Several Varieties of Rheumatism and Directions for their Treatment." I plate of illustrations. American Journal Medical Sciences, October, 1867, p. 19.