■ { lH ■ ■ H ■ .- I r p- PRACTICAL OBSERVATIONS ETIOLOGY, PATHOLOGY, DIAGNOSIS, AND TREATMENT ANAL FISSURE. BY WILLIAM BODENHAMER, A.M., M.D., PROFESSOR OF THE DISEASES, INJURIES, AND MALFORMATIONS OF THE RECTUM, ANUS, AND GENITO-URINARY ORGANS. " Truth is not the child of authority, but of time ; and were we to allow ourselves to suppose, that nothing more, or new, could be taught, it is pretty clear that nothing more, or new, would be learnt." —Lord Bacon. " Nunquam aliud natura, aliud sapientia dicit." — Juvenal. ILLUSTRATED BY NUMEROUS CASES AND DRAWINGS. NEW YORK r WILLIAM WOOD & CO., 61 WALKER STREET. 1868. O w* Entered according to Act of Congress, in the year 1868, by WILLIAM WOOD & CO., In the Clerk's Office of the District Court of the United States for the Southern District ol New York. The New York Printing Company, 81, 83, and 85 Centre St., New York. PREFACE, The exquisitely painful affection termed fissure of the anus, notwith- standing the labors of some of the most eminent surgical authors, is yet by no means well understood by the profession. The diagnosis, as well as the treatment of it, is far from being established upon a solid basis. There is as yet no agreement even, among surgical writers, as to the precise applica- tion of the term fissure of the anus, and there still exists a great diversity of opinion as to the best method of cure. The author is therefore of opin- ion that there is much still to be learned in relation to this disease, and that it requires more careful research for its further elucidation. A more thorough and critical investigation of the subject would now seem to be the more especially necessary, since some of the authorities in treating it, have completely mixed up and confounded disease, cause and effect, thereby occasioning much obscurity and confusion, which prove a formidable obstacle to a correct understanding of the true nature, cause, and treatment of this distressing malady. The erroneous and conflicting opinions of these authors, however, might be passed by without note or comment, as harmless, did they not lead to a treatment not only wrong in principle, but most mis- chievous in practice. The author's object, therefore, in this work will be principally confined to the consideration of the disease to which the term fissura ani really, truly, and legitimately belongs ; and by so doing endea- vor to remove some of the obscurities, the difficulties, and the confusion which surround it. Besides these several considerations, which led the author more immedi- ately to call the attention of the profession to the subject of this affection, there are others equally weighty. There is no complete and systematic treatise on the subject, and the disease is of exceedingly practical importance, in consequence of the great suffering to which it gives rise, and its frequent occurrence in our own country, and from the fact of its being not unfre- quently overlooked, or confounded with some other disease. It is also highly interesting from the circumstance that it admits, if well understood and judiciously treated, of speedy and complete relief without resorting to IV PREFACE. the grave operation of M. Boyer, or any other serious or formidable measure. Whilst on the other hand, when not well understood, it is liable through misdirected measures to be seriously aggravated. Great good may be done by one well acquainted with the disease, while much harm by one who treats it ignorantly. Anal fissure is by no means uncommon in this country, although some eminent authors are of opinion that the disease, as described by M. Boyer, is extremely rare, being scarcely ever observed by American practitioners. The able and highly accomplished medical writer, Dr. Reynell Coates, of Philadelphia, who is the author of the most able production on anal fissure in this country, remarked in 1841, that — "We have never met with it, either in public or in private practice, and several eminent surgeons in Philadelphia declare that it has not occurred under their observation." (American Cyclopaedia of Practical Medicine and Surgery. Vol. II. p. 118. Philadelphia, 1841.) That this disease is not rare or uncommon in this country, the author himself has had ample opportunities of verifying, during a practice of thirty years in the cities of New Orleans, La., Louis ville, Ky., and New York ; having within this period treated, he is sure, more than a thousand cases. This, it seems to him, must be the experience of every surgeon of extensive practice, especially of those in our large cities. So far as the author's treatment of this disease is concerned, he has nothing new to offer in this work. He has no novel method to recommend, which, by some species of coup de main practice, would hold out to both the sur- geon and the patient an instantaneous or miraculous cure, by which to excite the enthusiasm of the former and the hopes of the latter. He has only recommended a steady and a skilful perseverance in carrying out the practice of well known, long tried, and safe measures to a successful issue ; — hence he is aware that his treatment will be unattractive to those purely surgical enthusiasts who delight more in obtaining their ends by a prompt recourse to the knife, or to manual force, than by the milder, safer, and surer measures offered in the judicious practice of a long tried, less ostenta- tious, though much more solid and conservative method of cure. In this work, besides the method especially adopted and recommended by the author, he has, as far as his knowledge extends, fully given all other methods, from the earliest times, with all the improvements, down to the present ; and, for the benefit of the student as well as the practitioner, this has been done in as succinct, as practical, and as accessible a form as possible, or as the nature of the case would admit. It may be alleged by the learned and the experienced that, in treating such an apparently simple subject as anal fissure, the author has been too prolix, too diffuse ; but let it be remembered that he has not written entirely PREFACE. V nor even principally for these. " Doctis indoctisque scribimus" It is the great aim of the author to make that which is true, rather than that which is new, more generally known through all the ranks of the profession. Should this work, as the author humbly trusts it may, aid in clearing the diagnosis of anal fissure and spasmodic contraction of the sphinctores ani ; or in removing some of the obscurities, perplexities, and doubts to a clear understanding of the true character and treatment of fissure of the anus, he will feel amply rewarded for his labor. But, whether this expectation is realized or not, he has at least endeavored, to the best of his ability, to accomplish all that an individual under such circumstances could hope to effect, by candidly and fully submitting to the profession everything on this subject which a considerable experience, both in reading and in practice, has instructed him. In conclusion, the author would observe that he has illustrated this work by a number of diversified cases, some of which he treated many years ago, and by numerous drawings. The instruments represented by some of these were manufactured at the old established house of Messrs. George Tiemann & Co., No. 6j Chatham Street, New York. The intelligence and the in- genuity of the members of this firm, as surgeons' artists, the author has had, for a number of years, the most ample opportunities of witnessing. New York, October,. 1868. TABLE OF CONTENTS. CHAPTER I. INTRODUCTION. Section I. History. — Progress, the all-absorbing and controlling idea of the age. The science of medicine no exception to this all-prevailing principle : its upward and onward tendency evident. The ignorance heretofore on the subject of the diseases of the anus and the rectum. The failure to make a proper exploration of the rectum one of the causes of this ignorance. Since the introduction of anaesthetics, the surgery of the rectum, especially its manipulative branch, has made rapid progress. These, and the now common use of the speculum ani and the rectal endoscope, are daily revealing the dark and hidden mysteries of this darksome passage. Fissure of the anus received but little attention previous to the time of MM. Boyer, Beclard, Dupuytren, Blandin, and a few others. About fifty years ago, M. Boyer called especial attention to the subject of this disease, from having treated a large number suffering from it in its most aggravated form. He was of opinion that the disease called fissure of the anus, by the ancients as well as by the moderns, was not identi- cal with that which had come under his own observation ; and that previous to his time this disease was never observed with attention, neither was it accurately described nor correctly treated by any one. From this sweeping declaration the author dissents in toto. A comparison between the fissura ani of the ancients and that described by M. Boyer. The former believed it to be simply what its name imports, a superficial breach of surface of the mucous membrane, of a peculiar form ; the latter believed anal fissure to be always accompanied by a painful spasmodic con- traction of the sphincter ani muscle, and that this painful contraction indeed consti- tuted the real disease, whether attended by any breach of surface or not ; the former, that it was an idiopathic disease of the mucous membrane ; the latter, that it was an idiopathic disease of the sphincter ani muscle itself. The ancients, when speaking of fissura ani, do not mention anal spasm. What Paulus /Egineta, Albucasis and iEtius say on the subject of fissura ani. The chief indication in the treatment of this disease by the ancients was to convert the original fissure or ulcer into a recent wound by scarification and by topical medication. It is worthy of remark, that a fresh wound made in the mucous membrane, or in the irritable fissure of the same, is not attended with the same severe suffering, after the act of defecation, that arises from the original fissure or idiopathic disease ; that such a wound produces at first nothing but a common soreness, but at the same time tends to relieve the pain and cure the disease. The ancients then, to cure this disease, converted the primitive or original lesion into a recent or fresh one, and thus ultimately healed it. What have Vlii TABLE OF CONTENTS. the moderns now any better than this ? Even if the fissure is attended by anal spasm, all that is necessary, as a general rule, to effect a radical cure is to heal the fissure, and the anal spasm will cease of itself. From what M. Boyer says, he doubtless believed that he himself was the first to make the discovery that anal spasm always accompanied anal fissure, and that it was its characteristic or pathognomonic sign ; indeed, all his admirers attribute to him the origination of this idea. In this, how- ever, both he and they are mistaken, for nearly three hundred years before he or they promulgated this idea, the celebrated French surgeon, Ambrose Pare, accu- rately described the disease called fissure of the anus, as consisting of cleft and very long little ulcers, situated in the orifice and the canal of the anus, and attended by very sharp and burning pain, and by great contraction and narrowing of the anus. The description and the treatment of fissure of the anus given by M. Pare. The con- sideration of the theory of those of the moderns who teach that anal spasm is in reality the idiopathic disease, of which the breach of surface or fissure, if any, is but an accidental accompaniment or consequence. The views on this subject of each of the following eminent surgeons who held this doctrine, — MM. Boyer, Dupuytren, and Sir Benjamin Brodie. The declarations of these gentlemen, however, on this subject have never been verified by any satisfactory ante- ox post-mortem examination, and rest merely upon assertion. The views of MM. Blandin, Sanson, Quain, and Bushe in opposition to this theory. The views of M. Velpeau in conciliation of these conflicting theories. . Pages 3-21 Section II. Spasmodic Contraction of the Anus. — Nervous irritation in muscular parts often occasions partial and sometimes obstinate contractions. "When this occurs in the anal canal it constitutes what is generally called spasmodic contraction of the anus. There are three kinds of muscular contraction — the spasmodic, the perma- nent or organic, and the mixed, which partakes of the characters of both. The first can always be dilated to the full size of the canal in which it exists, and of which nothing can be learned by dissection after death, because the spasm depends upon a living and active principle which ceases with life. The second and third can not only be detected in life, but can be demonstrated post-mortem. How a spasmodic contraction may become permanent or fixed. Anal spasm as an entity a disease in itself. The independent existence of anal spasm is a theory held by some of the most able surgical writers on the diseases of the rectum and anus ; but as the principles of it rest purely upon the evidence of facts, fairly and fully ascertained and set forth, they fail, in the opinion of the author, to establish it. The author shows that the numerous cases which these writers have presented to illustrate this theory are, in reality, cases of anal fissure, or of some other disease of the mucous membrane of the inferior extremity of the rectum ; or of disease in the genito-urinary organs, and not cases of primary or independent disease of the sphincter ani muscle itself. The following are the authors quoted in this work who have treated anal spasm as an entity, a disease in itself, and who have made it a subject of special consideration : — M. Boyer, Mr. Copeland, Mr. Baillie, Mr. Gaitskell, Mr. Blackett, Mr. White, Mr. Howship, Mr. Calvert, Mr. Mayo, M. Chelius, Mr. Salmon, Dr. Bushe, Mr. Curling, and Mr. Malyn. The views and the cases of each of these authors given, with com- ments upon the same 21-40 TABLE OF CONTENTS. IX CHAPTER II. FISSURE OF THE ANUS. Section I. Name. — The disagreement among authors as to the precise application of the term fissure of the amis. It is incorrectly applied by some to anal spasm, a mere symptom of anal fissure, and by others equally incorrect to every superficial lesion of what- ever character, situated in the inferior extremity of the rectum, and about the margin of the anal orflce. The term fissure of the anus in its limited sense, or in its strict application. The term as used in its more extended sense. The difference in the form of these superficial lesions of the inferior extremity of the rectum and about the anal orifice. Their characteristic form is doubtless imparted to them by the irregularities of the mucous lining of the rectum, disposed as it is into numerous rugae. This term not a good one to designate this painful affection, inasmuch as the mere form of the lesion, whether linear, circular, or oblong, is not the char- acteristic sign, neither does it determine the true nature of the disease. Its use, however, has been so long sanctioned by authority that the author does not feel at liberty to venture upon the substitution of a newly created one. The term thus retained by the author as a nosological distinction, he strictly confines to superficial breaches of surface in the anal region of a highly sensitive, irritable, or painful char- acter, whether linear, oblong, or circular ; or whether' attended by anal spasm or not. Mr. Curling very appi"opriately denominates fissure of the anus, " irritable ulcer of the rectum" He, together with Mr. Quain and Mr. Smith, of London, repudiates the term, fissure of the anus Pages 43-46 Section II. Physiology. — A brief description of anal fissure given as preliminary to the sub- ject of physiology. It is an idiopathic disease of the mucous membrane of the infe- rior portion of the rectum ; or of the muco-cutaneous coat about the anal orifice, and not a disease of the muscular coat, or muscular fibres of the intestine, nor of the sphincters of the anus. The excessively irritable and excitable fissure of the mucous membrane communicates its irritability and excitability to the muscular coat and to the sphinctores ani muscles, and causes one or both of them to contract violently. The sphincter ani muscles are sympathetically impressed or influenced by the morbid condition of the fissure — hence the spasm. In some morbid conditions of the anus, or anal region, whether induced by fissure or by some other cause, extreme sensi- bility of the nerves of the part and spasmodic contraction of the anus coexist as parts of the same disease. Sensibility of the terminal outlets of the body. The sensibility of all mucous membranes is greatest at the extremities, or the outlets of the canals which they line. The outlets of the body are supplied or endowed with a peculiar nervous influence which is obviously connected with their proper function. The direct cause of the extreme and agonizing pain in anal fissure is the result, to a great extent, of the violent involuntary spasmodic contraction of the sphincters of the anus upon the already highly sensitive and painful ulcer. This view of the subject is in accordance with the pathology of the disease, as well as with the physiological condition of both sphincters of the anus, whose involuntary contraction, both tonic X TABLE OF CONTENTS. and spasmodic, is entirely owing to a peculiar nervous endowment. The tonic and the. muscular contraction of the anal sphincters. The explanation of each. The influence of the will upon the anal sphincters. These two muscles stand in physio- logical function between the involuntary and voluntary system of nerves. The sup- position that a special nervous influence is necessary to govern the relaxation and the contraction of the anus has be*en entertained by several eminent physiologists. The views of the ingenious and talented Italian, Professor Bellingeri, on this subject. The fibres of the anal sphincters may be stimulated to action directly by the will, or indirectly by reflex irritation, the one action being voluntary and the other involun- tary. The philosophy of reflex action in its relations to nervous phenomena is at the present time attracting great attention. To know that all morbid manifestations may be due to reflex influence is of the highest importance. The nervous endowment of the rectum. Hypertrophy of the external sphincter of the anus. . Pages 47-53 CHAPTER III. ETIOLOGY. Constipation of the Bowels as a Cause of Anal Fissure. — The ancients attributed fissure of the anus principally to constipation of the bowels, and to the desiccated condition of the stercoraceous matters incident to such a constipated state. It is obvious how constipation with all its train of evils, retention and induration of the faeces, and the violent action of the expulsive muscles requisite for their evacua- tion, may be a cause of anal fissure. Anal fissure is sometimes the result of inflam- mation, and the attendant turgescence of the mucous membrane of the anal canal. It also sometimes results from the excoriations produced by the vitiated and irrita- ting discharges in dysentery, diarrhoea, cholera, and other visceral diseases. Obstinate ulcers or fissures are sometimes produced in the fossa between the two anal sphinc- ters, by the continued lodgment in this situation of faecal matter or other foreign bodies. Severe straining efforts a cause of anal fissure. A somewhat frequent cause is a deficiency in the secretion of the natural lubricants — the mucous and other secre- tions of the inferior extremity of the rectum and about the anal orifice. Anal fissure from mechanical injuries, such as the lacerations which are produced by over disten- tion, by the passage of hard fasces, as well as those which sometimes follow surgical operations, and the careless and awkward use of the pipe of the enema syringe, the speculum ani, the rectal sound or bougie. It is sometimes the result of external vio- lence communicated by falls, blows, etc., upon the anus, the nates, or the coccyx. Anal contraction as a cause of anal fissure. Anal fissure from the frequent use of enemata. Anal fissure from cutaneous affections. The venereal origin of anal fissure. Can anal fissure be produced artificially ? Are the causes of anal fissure obscure ? Who are the most obnoxious to anal fissure ? 57—67 CHAPTER IV. CLASSIFICATION AND DESCRIPTION OF ANAL FISSURE. Section I. The Seat, the Anatomical and the Pathological Characters of Anal Fissure. — The importance of distinguishing and describing fissures of the anus in TABLE OF CONTENTS. XI accordance with their location. Some authors think such distinction of no therapeu- tical value. The great difference in the appearance of the fissure or ulcer, arising from its location. MM. Blandin and Dupuytren acknowledge the importance of such distinction. M. Blandin divides anal fissures into three divisions. The author distinguishes them into four classes, according to their locality, describing the pecu- liar character they assume in each of such position. A description of the seat, the anatomical and the pathological character of each class. . . . Pages 71-78 Section II. The Symptoms and the Signs of Anal Fissure. — The most striking feature in the nature of anal fissure is the great disproportion which exists between the extent of the solution of continuity, and the intense suffering it occasions. The character- istic or essential symptoms of anal fissure. The interval of time and its length between the act of defecation and the accession of the pain, as a pathognomonic sign of anal fissure. What Mr. Colles and Mr. Quain say on the subject of this phenom- enon. The explanation given of it by Prof. Van Buren and Mr. Malyn. Symptoms and signs of anal fissure in infants. They differ essentially from those manifested in the adult. The difference pointed out 79~9° Section III. Physical Exploration, Diagnosis, and Prognosis. — The measures necessary to be observed previous to making a thorough inspection of the rectum. The posi- tion of the patient and the manner of making the exploration. The external appear- ance of the anus in anal fissure. It is almost always strikingly retracted. The condyloma or pendulous projection, composed of the integument at the margin of the anus, and located at the base or inferior extremity of the fissure. It exists in most all cases, and is an unerring guide to the fissure itself. The digital exami- nation of the anal canal and the preparatory measures necessary for it. The specular examination of the inferior extremity of the rectum and the preparatory steps necessary to it. Description of three anal speculae used by the author. The examination by means of the probe. The diagnosis. The prognosis. The com- plications of anal fissure. . 90-103 CHAPTER V. THE TREATMENT. Section I. Precautionary and Palliative Measures. — It is highly important to the suc- cess of any treatment of fissure of the anus that constipation of the bowels, if it exists, should be corrected, by securing their daily evacuation, and thereby preventing faecal accumulation. It is also a primary object to prevent the formation of acrimonious matter in the bowels, and to take especial care to preserve an easy and regular trans- mission of their contents, which for this purpose should as much as possible be kept in a semi-fluid state, as figured or hard stools generally aggravate the symptoms. Xll TABLE OF CONTENTS. These several ends must be effected by enjoining the most bland and unirritating diet ; and by the use of emollient enemata, or mild aperients. The measures recommended by the author to accomplish the certain evacuation of the bowels daily, and the easy - transmission of their contents. The following as palliatives to be used sometimes in certain cases and under certain circumstances — leeching, fomentation, horizontal posture, cold applications, and local anaesthesia. The palliative measure of M. Gossement Pages 107-109 Section II. The Treatment as Pursued by the Author. — It consists of topical medi- cation combined with dilatation and sometimes scarification or incision of the mucous membrane. The chief indication is to modify the surface of the ulcer and transform it into a simple or a common sore. Distention of the spasmed anal sphincters ; its object, and the method of accomplishing it. The author's method of treating anal fissure in infants. 110-119 Section III. The Different Methods of Treatment. — These may be included under the following heads : — 1. Topical Applications ; — 2. Cauterization ; — 3. Dilatation ; — 4. Incision of the Mucous Membrane ; — 5. Excision of the Fissure ; — 6. Complete Divi- sion of the Sphincters of the Anus. The treatment by topical applications. It is said by some to be merely palliative, and by others to be impracticable, or positively injurious. The author proves by the highest authority, that it has not only been found practicable, but that it has been attended with the most complete success in numerous instances. The numerous and various topical applications given, together with the names of those who employed them, and the success or failure attending their application. 2. The treatment by cauterization. The indication contemplated by the use of the cautery, either in its potential or in its actual form. The potential cautery employed in the treatment of fissura ani from the earliest times. The dif- ferent kind of caustics, with their mode of application. M. Jules Guerin recommends the actual cautery. Objections to this remedy. 3. The treatment by dilatation. The object and the method of employing it in anal spasm when caused by fissure of the anus. Dilatation by the use of the bougie. It was employed and recommended by Mr. Copeland, Mr. Gaitskell, and Mr. Howship as early as 1815. The principle of muscular distention and dilatation as recommended and so successfully employed by M. Recamier. Dilatation by the use of different kinds of tents. Forcible and instantaneous dilatation of the sphincters of the anus by means of the fist, was first executed and recommended by M. Maisonneuve. This operation met with no favor. A modification of this operation was subsequently made, by substituting the thumbs for the fist. The manner of performing it as practised by M. Nelaton, who is its advocate. This method of dilatation of the anal sphincter in fissure of the anus and some other diseases of these parts is adopted and recommended by Professor Van Buren. The objections. A modification of it recommended by the author, in which the index fingers are used instead of the thumbs. 4. The treatment by incision of the mucous membrane. Mr. Copeland the first who recommended it as a substitute for M. Boyer's operation. What Sir Benjamin Brodie and Mr. Quain say on this subject. Mr. Curling and Mr. Smith are of opinion, that besides the division of the mucous membrane and submucous cellular tissue, it is necessary to the success TABLE OF CONTENTS. Xlll of the operation that some of the muscular fibres should be divided. The author differs from this opinion. The modus operandi of this operation. The author's method of performing it by a new instrument. 5. The treatment by excision of the fissure. This operation, the author believes, was first proposed and executed by M. Velpeau. In it the integrity of the muscular coat is preserved, neither the muscle nor the muscular fibres of it being interfered with. The modus operandi. 6. The treatment by complete division of the anal sphincters. The merit of first executing and recommending this operation in case of anal fissure, is universally attributed to M. Boyer. The objections to this operation. It is founded upon a mere hypothesis. The anal spasm for which the operation is advised is only a symptom, an effect, or a result of the fissure, which is in reality the real disease. The operation is wrong in principle and mischievous in practice, and cannot be approved of, upon rational grounds. All treatment is irrational that is not immediately directed to the morbid condition of the mucous membrane of the part, or that does not immediately tend to heal the fissure itself, which is the real disease. The operation was considered to be infallible by M. Boyer ; it is, however, proved by MM. Recamier, Beclard, Velpeau, and others, not to be so. The accidents and the dangers of the operation. The manner of performing it as advised by M. Boyer. A modification of M. Boyer's operation by M. Blandin. It consists of the submucous and subcutaneous section of the sphincter ani muscle. It is ingenious, simple, far less formidable and repulsive, equally successful, and attended with much less risk. A description of the instru- ment, and the manner of performing the operation. The proceeding of M. Boyer as modified by the late and lamented Dr. Hayward, of Boston. It consists of the divi- sion of the sphincter ani from without inwards, instead of from within outwards, as in the operation for complete fistula in ano. The manner of performing the opera- tion. Pages 1 19-147 CHAPTER VI. CONCLUSION. Section I. Illustrative Cases. — Case I. Anal fissure of nine months' standing, caused by obstinate constipation of the bowels, and the continued use of drastic purgatives. Case II. Anal fissure complicated with haemorrhoids. Case III. Anal fissure com- plicated with a small blind internal fistula — the patient having been treated several months for internal irritable piles. Case IV. Anal fissure of an aggravated char- acter, in which the sphincters of the anus had been divided with the knife. Case V. Anal fissure in a little boy three years old, caused by obstinate constipation of the bowels, the result of inactivity of the liver induced by intermittent fever. Case VI. Anal fissure complicated with fistula in ano, spermatorrhoea, and ascarides of the rec- tum. Case VII. Anal fissure complicated with a blind internal fistula. Case VIII. Highly irritable ulcer, situated in the fossa between the external and internal sphinc- ter of the anus. Case IX. Irritable ulcer of the rectum simulating uterine disease, and a large accumulation of hard and impacted faeces in the left colon simulating a tumor in that region. Case X. Anal fissure in an infant ten months old. Dentition, XIV TABLE OF CONTENTS. persistent diarrhoea, and procidentia ani. Case XI. Anal fissure, previously diag- nosed and treated by different physicians, severally as neuralgia of the inferior extremity of the rectum, internal piles, and constipation. Case XII. Anal fissure attended by great flatulency, and accompanied alternately by constipation and diar- rhoea. The true nature of the case having been overlooked, it was treated severally as dyspepsia, anal neuralgia, and internal piles. Case XIII. Anal fissure compli- cated with haemorrhoids. In this case the fissure, having been entirely overlooked by the previous medical attendants, was diagnosed and treated by them as irritable piles. Case XIV. Anal fissure complicated with haemorrhoids and with spermator- rhoea. Case XV. Anal fissure the result of the application of nitric acid to the mu- cous membrane of the anal canal. Case XVI. Anal fissure from a rupture of the mucous membrane of the anal canal, the result of a fall upon the nates. Case XVII. Several fissures complicated with numerous condylomata and with permanent contraction of the anus. Case XVIII. Anal fissure complicated with an intolerable pruritus of the anus. Case XIX. Anal fissure in an infant suffering from aphthae. Case XX. Anal fissure complicated with haemorrhoids and an affection of the pros- tate gland. Case XXI. Anal fissure complicated with haemorrhoids, the fissure ocated between two of them. Case XXII. Anal fissure caused by chronic irritation of the mucous membrane and muco-cutaneous coat of the anus. Error in diagnosis and failure to afford relief by previous treatment. Case XXIII. Anal fissure in a nursing mother who was suffering severely from aphthae. Case XXIV. Anal fissure complicated with haemorrhoids and with an anal fistula. Case XXV. Fissures and aphthous abrasions and ulcerations of the anus in connection with nurses' sore mouth. Case XXVI. Anal fissure following the ligation and sloughing of a haemorrhoidal tmnor. Case XXVII. Anal fissure in a patient with albuminous urine, whose gen- eral health was much impaired. Case XXVIII. Anal fissure the result of obstinate constipation of the bowels, and the passage of scybalous faeces. Case XXIX. Ir- ritable ulcer, situated in the fossa between the external and internal sphincter of the anus Pages 151-192 Section II. Bibliography. 192-199 CHAPTER FIRST. INTRODUCTION. PRACTICAL OBSERVATIONS ON THE ETIOLOGY, PATHOLOGY, DIAGNOSIS, AND TREATMENT OF ANAL FISSURE. CHAPTER I. INTRODUCTION. Section I. — History. Progress, either in remodelling the ancient order of things, or in creating a new one, is the one and controlling idea of the present age, and no theories that stand in the way can long exist. Systems and doctrines, gray with the growth of ages, are in a few days overthrown and swept away like cobwebs, although crystallized by time, and fortified by the genius and labors of a hundred generations. The science of medicine is no exception to this all-prevailing principle, as it too is now rapidly moving onwards and upwards. There is no better evidence of the rapid march of medical science at the present time than is found in the increased accuracy of diag- nosis, aided by a careful study of the physical signs of disease. The ignorance on the subject of the diseases of the rec- tum which had so long prevailed, and which to a certain extent still more or less exists, may very justly be attributed to the failure on the part of practitioners generally to make a proper exploration of this organ. The rectum heretofore ANAL FISSURE. has been a terra incognita in the domain of surgery, into which the practitioner did not care to pry : it has been con- sidered a