v* y GENERAL SURGICAL PATHOLOGY AND THERAPEUTICS |n Jfx%-0tt£ $ettttws. A TEXT-BOOK FOR STUDENTS AND PHYSICIANS. BY / Dr. THEODOK BILLROTH, PROFESSOR OF SURGERY IN VIENNA. TRANSLATED FROM THE FOURTH GERMAN EDITION, WITH THE SPECIAL PERMISSION OF THE AUTHOR, AND REVISED FROM THE EIGHTH EDITION, BY CHARLES E. HACKLEY, A. M., M. D., PHYSICIAN TO THE NEW YORK HOSPITAL, FELLOW OF THE NEW YORK ACADEMY OF MEDICINE, ETC., ETC. ^O0PYRi6W?^R [{jvo.JjAZJtjj \ fa 1879. W NEW YOKK: D. APPLETON AND COMPANY, 549 & 551 BROADWAY. 1879. r ci* ^ 5 \ Entered, according to Act of Congress, in the year 1871, by Charles E. Hacxley, in the Office of the Librarian of Congress, at Washington. Entered, according to Act of Congress, in the year 1873, by Charles E. Hacklet, in the Office of the Librarian of Congress, at Washington. Entered, according to Act of Congress, in the year 1879, by Charles E. Hackley, in the Office of the Librarian of Congress, at Washington. TRANSLATOR'S PREFACE TO THE REVISED EDITION. Since this translation was revised from the sixth German edition in 1874, two other German editions have been pub- lished. The present revision is made to correspond to the eighth German edition. In order to make use of the stereotype plates of the former edition as far as possible, some of the additions have been inserted in an appendix. These are numbered, and are referred to in the text by corresponding numbers. Lister's method of antiseptic treatment is referred to in various places ; and other new points that have come up within a few years are discussed. A chapter has been written on ampu- tations and resections. In all there are seventy-four additional pages, with a number of new woodcuts. CHAS. E. HACKLEY, M.D. New York, December, 1878. TRANSLATOR'S PREFACE. During the past ten years the microscope has greatly ad- vanced our knowledge of Pathology; and it will perhaps be acknowledged that most progress in the study of Pathological Anatomy has been made in Germany. Prof. Theodor Billroth, himself one of the most noted au- thorities on Surgical Pathology, has in the present volume given us a complete resume of the existing state of knowledge in this branch of medical science. The book might perhaps have been entitled " Principles of Surgery," but this would hardly have indicated the specific man- ner in which these principles have been inculcated. Most of the views found in these lectures have been floating through the journals for several years past ; but, so far as the translator knows, they are not so fully presented in any book in the English language. The only work in our language on the subject was published many years ago ; even the late editions are but little changed from the first ; moreover, the two works are, in most respects, entirely unlike. The fact of this publication going through four editions in Germany, and having been translated into French, Italian, Rus- sian, and Hungarian, should be some guarantee for its standing. Some few notes that have been inserted by the translator will be found enclosed in brackets [ ]. New York, December 1, 1870. PREFACE TO THE EIGHTH GERMAN EDITION. This edition also lias been carefully revised, and some addi- tions have been made to it. It is the hope of the author that the book will continue to be acceptable and beneficial to students of surgery. In addition to previous translations, there has been a new English one made under the auspices of the New Sydenham Society, as well as one into Japanese by Dr. Susum Sato. TH. BILLEOTH. AUTHOR'S PREFACE TO THE SIXTH EDITION. The steady advance of science, and the progress that we onr selves make as long as we have the inclination and strength to swim with the stream, become most apparent when we are from time to time obliged to go over our old work. On a similar occasion I have already expressed this thought, but do not hesi- tate to repeat it here ; for this perception of progress is a great support to us in the many dark hours when, with the greatest zeal to serve our fellow-men, we feel oppressed by the impotence of our knowledge and ability. I have again done my best to raise this book to the present level of our knowledge, and have untiringly striven to improve its form and contents ; the section on Deformities has been en- tirely rewritten, old woodcuts have been replaced by better ones, and some new ones have been added ; prescriptions have been given in grammes. May this enlarged edition also be well received, and arouse in the student a love of surgery ! TH. BILLROTH. Vienna, November, 1872. PREFACE TO THE FOURTH EDITION. Almost every time that it has become my pleasant task to go over this book in preparing a new edition, I have thought, this time at least, there will not be mnch to alter ; nevertheless, I always found much, very much to improve, to cut out or to add. In so doing, I have always had the satisfaction of knowing that even in short periods the progress of science had been quite perceptible. We do not notice this much while swimming with the stream, but it becomes very evident when we have before us a book that is to a certain extent a photogram of the state of affairs two years since. The success that this edition meets with will show whether I have again succeeded in presenting my book in a shape to meet the requirements of physicians and students. The section on traumatic inflammation has been revised in accordance with recent advances. In the chapter on tumors, the part treating of carcinoma has been simplified, the term " connective-tissue cancer " being omitted, to prevent confusion. The liberality of the publisher has enabled me to increase the number of woodcuts by twenty-nine (Figs. 47, 53, 55, 58, 66, 68, 69, TO, 74, 91, 98, 99, 103, 106, 107, 108, 109, 110, 111, 112, 122, 123, 124, 125, 126, 127, 128, 132, 133). De. TH. BILLROTH. A^ienna, November, 1869. CONTENTS. LECTUEE L INTRODUCTION. Relation of Surgery to Internal Medicine. — Necessity of the Practising Physician being acquainted with both. — Historical Bemarks. — Nature of the Study of Sur- gery in the German High-school, page 1 CHAPTER I. SIMPLE INCISED WOUNDS OF THE SOFT PARTS. LECTUEE II. Mode of Origin and Appearance of theae "Wounds. — Various Forms of Incised "Wounds. — Appearance during and immediately after their Occurrence. — Pain, Bleeding. — Varieties of Haemorrhage ; Arterial, Venous. — Entrance of Air through "Wounded Veins. — Parenchymatous Haemorrhage. — Haemorrhagic Diathesis. — Haemorrhage from the Pharynx and Eectum. — Constitutional Effects of Severe Haemor- rhage, p. 17 LECTUEE III. Treatment of Haemorrhage. — 1. Ligature and Mediate Ligature of Arteries. — 2. Com- pression by the Finger ; Choice of the Point for Compression of the Larger Arte- ries. — Tourniquet. — Acupressure. — Bandaging. — Tampon. — 3. Styptics. — General Treatment of Sudden Anaemia. — Transfusion, . .... p. 26 LECTUEE IV. Gaping of the "Wound. — Union by Plaster. — Suture ; Interrupted Suture ; Twisted Su- ture. — External Changes perceptible in the United "Wound. — Healing by First In- tention, p. 41 LECTUEE V. The more Minute Changes in Healing by the First Intention.— Dilatation of Vessels in the Vicinity of the "Wound. — Fluxion. — Different Views regarding the Causes of Fluxion, p. 49 LECTUEE VI. Changes in the Tissue during Healing by the First Intention. — Plastic Infiltration. — Inflammatory New Formation. — Eetrogression to the Cicatrix. — Anatomical Evi- x CONTENTS. dences of Inflammation. — Conditions under which Healing by First Intention does not occur.— Union of Parts that have been completely separated, . . page 58 LECTUEE VII. Changes perceptible to the Naked Eye in Wounds with Loss of Substance.— Finer Pro- cesses in Healing with Granulation and Suppuration. — Pus. — Cicatrization. — Obser- vations on "Inflammation." — Demonstration of Preparations illustrative of the Healing of Wounds, p. 70 LECTUEE VIII. General Eeaction after Injury. — Surgical Fever. — Theories of the Fever. — Prognosis. — Treatment of Simple Wounds and of Wounded Persons. — Burrowing Wounds. — Open Treatment of Wounds.— Lister's Method.— Coccobacteria Septica, . p. 88 LECTUEE IX. Combination of Healing by First and Second Intention. — Union of Granulation Surfaces. Healing under a Scab. — Granulation Diseases. — The Cicatrix in Various Tissues ; in Muscle; in Nerve; its Knobby Proliferation; in Vessels. — Organization of the Thrombus. — Arterial Collateral Circulation, . . . . . . . p. 99 CHAPTER II. SOME PECULIARITIES OF PUNCTURED WOUNDS. LECTUEE X. As a Eule, Punctured Wounds heal quickly by First Intention. — Needle Punctures ; Needles remaining in the Body, their Extraction. — Punctured Wounds of the Nerves. — Punctured Wounds of the Arteries : Aneurysma Traumaticum, Varicosum, Varix Aneurysmaticus. — Punctured Wounds of the Veins, Venesection, . .p. 130 CHAPTER III. CONTUSIONS OF THE SOFT PARTS WITHOUT WOUNDS. LECTUEE XI. Causes of Contusions. — Nervous Concussion. — Subcutaneous Eupture of Vessels. — Bup ture of Arteries.— Suggillations. — Ecchymoses. — Eeabsorption. — Termination in Fibrous Tumors, in Cysts, in Suppuration, and Putrefaction. — Treatment, p. 141 CHAPTER IV. CONTUSED AND LACERATED WOUNDS OF THE SOFT PARTS. LECTUEE XII. Mode of Occurrence of these Wounds ; their Appearance. — Slight Haemorrhage in Con- tused Wounds. — Early Secondary Haemorrhages. — Gangrene of the Edges of the Wound. — Influences that effect the Slower or more Eapid Detachment of the Dead Tissue. — Indications for Primary Amputation. — Local Complications in Contused Wounds ; Decomposition, Putrefaction, Septic Inflammations.— Contusion of Ar- teries ; Late Secondary Haemorrhages, p. 152 CONTEXTS. xi LECTUKE XIII. Progressive Suppuration starting from Contused Wounds. — Secondary Inflammations of the "Wound: their Causes; Local Infection. — Febrile Eeaction in Contused Wounds : Secondary Fever ; Suppurative Fever ; Chill ; their Causes. — Treatment of Contused "Wounds : Immersion, Ice-bladders, Irrigation ; Criticism of these Methods. — Incisions. — Counter-openings. — Drainage. — Cataplasms. — Open Treat- ment of "Wounds. — Prophylaxis against Secondary Inflammations. — Internal Treat- ment of those severely "Wounded. — Quinine. — Opium. — Lacerated "Wounds : Sub- cutaneous Eupture of Muscles and Tendons ; Tearing out of Muscles and Tendons ; Tearing out of Pieces of a Limb, page 164 CHAPTER Y. SIMPLE FRACTURES OF BOXES LECTUKE XIV. Causes, Different Varieties of Fractures. — Symptoms, Diagnosis.— Course and External Symptoms. — Anatomy of Healing, Formation of Callus.— Source of the Inflamma- tory Osseous New Formation. — Histology, p. 185 LECTUEE XV. Treatment of Simple Fractures.— Eeduction. — Time for applying the Dressing, its Choice. — Plaster of Paris and Starch Dressings, Splints, Permanent Extension. — Eetaining the Limb in Position. — Indications for removing the Dressings, p. 201 CHAPTER VI. OPEN FRACTURES AND SUPPURATION OF BONE. Difference between Subcutaneous and Open Fractures in regard to Prognosis. — Vari- eties of Cases. — Indications for Primary Amputation. — Secondary Amputation. — Course of the Cure. — Suppuration of Bone. — Necrosis of the Ends of Frag- ments, p. 210 LECTUEE XVI. Development of Osseous Granulations. — Histology. — Detachment of the Sequestrum. — Histology. — Osseous New Formation around the Detached Sequestrum. — Callus in Suppurating Fractures. — Suppurative Periostitis and Osteomyelitis. — General Con- dition. — Fever. — Treatment ; Fenestrated, Closed, Split Dressings. — Antiphlogis- tic Eemedies. — Immersion. — Lister's Method. — Eules about Bone-splinters. — After-Treatment, . p. 216 APPENDIX TO CHAPTERS V. AND VI. LECTUEE XVII. 1. Eetarded Formation of Callus and Development of Pseudarthrosis.— Causes often unknown. — Local Causes. — Constitutional Causes. — Anatomical Conditions. — Treatment: internal, operative; Criticism of Methods. 2. Obliquely-united Fractures; Eebreaking, Bloody Operations. — Abnormal Development of Cal- lus, p. 226 xii CONTENTS. CHAPTER VII. INJURIES OF THE JOINTS. Contusion.— Distortion.— Massage. — Opening of the Joint, and Acute Traumatic Ar- ticular Inflammation. — Variety of Course, and Kesults. — Treatment. — Anatomical Changes, page 234 LECTUEE XVI11. Simple Dislocations; Traumatic, Congenital, Pathological Luxations, Subluxations. — Etiology. — Difficulties in Eeduction, Treatment; Eeduction, After-Treatment. — Habitual Luxations. — Old Luxations, Treatment. — Complicated Luxations. — Con- genital Luxations, p. 242 CHAPTER VIII. G UNSHOT- WOUNDS. LECTUEE XIX. Historical Eemarks. — Injuries from Large Missiles. — Various Forms of Bullet-Wounds. — Transportation and Care of the "Wounded in the Field. — Treatment. — Compli- cated Gunshot-Fractures, p. 254 CHAPTER IX. BURNS AND FROST-BITES. LECTUEE XX. 1. Burns: Grade, Extent, Treatment.— Sunstroke.— Stroke of Lightning.— 2. Frost- bites : Grade. — General Freezing, Treatment. — Chilblains, . . .p. 266 CHAPTER X. ACUTE NON-TRAUMATIC INFLAMMATION OF THE SOFT PARTS. LECTUEE XXI. General Etiology of Acute Inflammations.— Acute Inflammation : 1. Of the Cutis. a, Erysipelatous Inflammation ; J, Furuncle ; c, Carbuncle (Anthrax), Pustula Ma- ligna. 2. Of the Mucous Membranes. 3. Of the Cellular Tissue, Acute Abscesses. 4. Of the Muscles. 5. Of the Serous Membranes, Sheaths of the Tendons, and Subcutaneous Mucous Bursa?, p. 277 CHAPTER XI. ACUTE INFLAMMATIONS OF THE BONES, PERIOSTEUM, AND JOINTS. LECTUEE XXII. Anatomy.— Acute Periostitis and Osteomyelitis of the Long Bones : Symptoms, Ter- minations in Eesolution, Suppuration, Necrosis, Prognosis, Treatment.— Acute Ostitis in Spongy Bones.— Multiple Acute Osteomyelitis.— Acute Inflammations of the Joints.— Hydrops Acutus ; Symptoms, Treatment.— Acute Suppurative In- flammations of Joints : Symptoms, Course, Treatment, Anatomy.— Acute Articular Eheumatism.— Arthritis.— Metastatic Inflammations of Joints (Gonorrhoeal, Py- emic, Puerperal), p. 300 APPENDIX TO CHAPTERS I.-XI. Eevicw.— General Eemarks about Acute Inflammation, p. 317 CONTENTS. xiii CHAPTER XII. GANGRENE. LECTURE XXII I. Dry, Moist Gangrene. — Immediate Causes. — Process of Detachment. — Varieties of Gan- grene according to the Remote Causes.— 1. Loss of Vitality of the Tissue from Mechanical or Chemical Causes. — 2. Complete Arrest of the Afflux and Efflux of Blood. — Incarceration. — Continued Pressure. — Decubitus. — Great Tension of the Tissue. — 3. Complete Arrest of the Supply of Arterial Blood. — Gangrena Spon- tanea. — Gangrena Senilis. — Ergotism. — 4. Noma. — Gangrene in Various Blood- Diseases. — Treatment, page 326 CHAPTER XIII. ACCIDENTAL TRAUMATIC AND INFLAMMATORY DISEASES, AND POISONED WOUNDS. LECTURE XXIV. I. Local Diseases which may accompany "Wounds and Other Points of Inflammation : 1. Progressive Purulent and Purulent Putrid Diffuse Inflammation of Cellular Tissue. — 2. Hospital Gangrene. — 3. Traumatic Erysipelas. — 4. Lymphangitis, p. 338 LECTURE XXV. 5. Phlebitis ; Thrombosis ; Embolism. — Causes of Venous Thrombosis ; Various Meta- morphoses of the Thrombus. — Embolism. — Red Infarction, Embolic Metastatic Abscesses.— Treatment, p. 353 LECTURE XXVI. II. — General Accidental Diseases which may accompany "Wounds and Local Inflamma- tions. 1. Traumatic and Inflammatory Eever ; 2. Septic Fever and Septicemia ; 3. Suppurative Fever and Pyemia, p. 362 LECTURE XXVII. 4. Tetanus; 5. Delirium Potatorum Traumaticum ; 6. Delirium Nervosum and Mania. — Appendix to Chapter XIII. — Poisoned "Wounds ; Insect-bites, Snake-bites ; Infec- tion from Dissecting Wounds. — Glanders. — Carbuncle. — Diseases from Mouths and Claws of Animals.— Hydrophobia, p. 386 CHAPTER XIV. CHRONIC INFLAMMATION ESPECIALLY OF THE SOFT PARTS. LECTURE XXVIII. Anatomy: 1. Thickening, Hypertrophy ; 2. Hypersecretion; 3. Suppuration, Cold Abscesses, Congestive Abscesses, Fistulas, Ulceration. — Results of Chronic Inflam- mation. — General Symptomatology. — Course. p. 403 LECTURE XXIX. General Etiology of Chronic Inflammation. — External Continued Irritation. — Causes in the Body. — Empirical Idea of Diatheses and Dyscrasiae.— General Symptomatology and Treatment of Morbid Diatheses and Dyscrasiae. 1. The Lymphatic Diathesis (Scrofula); 2. Tuberculous Dyscrasia (Tuberculosis); 3. The Arthritic Diathesis ; 4. The Scorbutic Dyscrasia ; 5. Syphilitic Dyscrasia, . . . .p. 410 XIV CONTENTS. LECTURE XXX. Local Treatment of Chronic Inflammation : Eest, Compression, Moist Warmth, Hy- dropathic Wraps, Eesorbents, Antiphlogistics, Derivatives, Eontanels, Setons, Moxas, the Hot Iron, page 429 CHAPTER XV. ULCERS. LECTURE XXXI. Anatomy. — External Peculiarities of Ulcers ; Form and Extent, Base and Secretion, Edges, Parts around. — Local Treatment according to the Local Condition of the Ulcer ; Fungous, Callous, Putrid, Phagedenic, Sinuous Ulcers, Etiology, Contin- ued Irritation, Venous Congestion, Dyscrasial Causes, . . . .p. 434 CHAPTER XVI. CHRONIC INFLAMMATION OF THE PERIOSTEUM, OF THE BONE, AND NECROSIS. LECTUEE XXXII. Chronic Periostitis and Caries Superficialis. — Symptoms. — Osteophytes. — Osteoplastic, Suppurative Forms. — Anatomy of Caries. — Etiology.— Diagnosis.— Combination of Various Forms, p. 448 LECTUEE XXXIII. Primary Central, Chronic Ostitis, or Caries. — Symptoms. — Ostitis Interna Osteoplas- ts, Suppurativa, Fungosa. — Abscess of Bone. — Combinations. — Ostitis with Cas- eous Metamorphosis. — Tubercles of Bone. — Diagnosis of Caries. — Dislocation of the Bones after their Partial Destruction. — Congestion Abscesses. — Etiology, p. 458 LECTUEE XXXIV. Process of Cure in Caries and Congestion Abscesses. — Prognosis.— General Health in Chronic Inflammations of the Bone. — Secondary Lymphatic Enlargements. — Treatment of Caries and Congestion Abscesses. — Eesections in the Conti- nuity, p. 468 LECTUEE XXXV. Necrosis. — Etiology. — Anatomical Conditions in Total and Partial Necrosis. — Symp- toms and Diagnosis. — Treatment. — Sequestrotomy, p. 479 LECTUEE XXXVI. Rachitis. — Anatomy. — Symptoms. — Etiology. — Treatment. — Osteomalacia. — Hypertro- phy and Atrophy of Bone, p. 495 CHAPTER XVII. CHRONIC INFLAMMATION OF THE JOINTS. LECTUEE XXXVII. General Remarks on the Distinguishing Characteristics of the Chief Forms. — A. Fun- gous and Suppurative Articular Inflammations (Tumor Albus), Symptoms, Anato- my, Caries Sicca, Suppuration, Atonic Forms. — Etiology.— Course and Prog- nosis, p. 508 CONTENTS. xv LECTURE XXXVIII. Treatment of Tumor Albus.— Operations.— Resection of the Joints.— Criticisms on the Operations on the Different Joints, page 514 LECTURE XXXIX. B. — Chronic Serous Synovitis. — Hydrops Articulorum Chronicus; Anatomy, Symp- toms, Treatment. — Typical recurring Dropsies of the Knee. — Appendix : Chronic Dropsies of the Sheaths of the Tendons, Synovial Hernias of the Joints and Sub- cutaneous Mucous Bursae, p. 524 LECTURE XL. C. — Chronic Rheumatic Inflammation of the Joints. — Arthritis Deformans. — Malum Coxae Senile. — Anatomy, Different Forms, Symptoms, Diagnosis, Prognosis, Treatment. — Appendix I. : Foreign Bodies in the Joints : 1. Fibrinous Bodies ; 2. Cartilaginous and Bony Bodies ; Symptomatology, Operations. — Appendix II. : Neuroses of the Joints, p. 534 LECTURE XLI. Anchyloses : Varieties, Anatomy, Diagnosis, Treatment ; Gradual Forced Extension ; Operations with the Knife, p. 546 CHAPTER XVIII. CONGENITAL DEFORMITIES OF THE JOINTS DUE TO MUSCULAR AND NER- VOUS AFFECTIONS AND CICATRICIAL CONTRACTIONS.- LOX ARTHROSES. LECTURE XLII. I. Deformities of Intra-uterine Origin due to Disturbances of Development of the Joint. — II. Deformities occurring only in Children and Young Persons, caused by Impaired Growth of the Joint. — III. Deformities from Contractions, or Paralysis of Single Muscles or Groups of Muscles. — IV. Limitation of Movements in the Joints from Contraction of Fasciae and Ligaments. — V. Cicatricial Contractions. — Treatment. — Extension by Apparatus, Straightening under Anaesthesia. — Com- pression.— Tenotomy and Myotomy. — Division of the Fasciae and Articular Liga- ments. — Gymnastics and Electricity. — Artificial Muscles. — Supporting Appara- tus, p. 558 CHAPTER XIX. VARICES AND ANEURISMS. LECTURE XLIII. Varices: Various Forms, Causes, Various Localities where they occur, — Diagnosis. — Vein-stones. — Varix Fistulae. — Treatment. — Varicose Lymphatics, Lymphorrhoea. — Aneurisms : Inflammation of Arteries. — Aneurysma Cirsoideum. — Atheroma. — Various Forms of Aneurism. — Their Subsequent Changes, — Symptoms, Results, Etiology, Diagnosis. — Treatment: Compression, Ligation, Injection of Liquor Ferri, Extirpation, p. 576 CHAPTER XX. TUMORS. LECTURE XLIV. Definition of the Term Tumor. — General Anatomical Remarks; Polymorphism of Tissues. — Points of Origin of Tumors. — Limitation of the Development of Cells to Certain Types of Tissue. — Relation to the Generative Layers. — Mode of Growth. — Anatomical Metamorphosis of Tumors; their External Appearances, . . p. 595 xvi CONTENTS. LECTUEE XLV. Etiology of Tumors ; Miasmatic Influence. — Specific Infection.— Specific Eeaction of the Irritated Tissues ; its Cause is always constitutional.— Internal Irritations ; Hypotheses as to the Character and Mode of the Irritant Action. — Course and Prognosis : Solitary, Multiple, Infectious Tumors. — Dyscrasia. — Treatment. — Prin- ciples of the Classification of Tumors, ....... page 605 LECTUEE XLVI. 1. Fibromata: a, Soft; b, Hard Fibroma. — Mode of Occurrence ; Operations; Ligature; Ecrasement ; Galvano-caustic. — 2. Zipomata : Anatomy ; Occurrence ; Course. 3. Chondromata: Occurrence; Operation. — 4. Osteomata: Forms; Operation, p. 618 LECTUEE XLVII. 5. Myoma. — 6. Neuroma. — 7. Angioma: a, Plexiform; J, Cavernous. — Operations, p. 637 LECTUEE XLVIH. 9. Sarcomata.— Anatomy : a, Granulation Sarcoma ; 5, Spindle-celled Sarcoma ; c, Giant- celled Sarcoma ; d, Stellate Sarcoma ; e, Alveolar Sarcoma ; y, Pigmented Sarcoma. — Clinical Appearance. — Diagnosis. — Course. — Prognosis. — Mode of Infection. — Topography. — Central Osteosarcoma. — Periosteal Sarcoma. — Sarcoma of the Mam- ma, of the Salivary Glands. — 9. LympTiomata. — Anatomy.— Eelations to Leucaemia. — Treatment, p. 645 LECTUEE XLIX. 10. Papillomata. — 11. Adenomata. — 12. Cysts and Cystomata.— Follicular Cysts of the Skin and Mucous Membranes. — Neoplastic Cysts. — Cysts of the Thyroid Gland. — Ovarian Cysts. — Blood-Cysts, p. 666 LECTUEE L. 13 Carcinomata. — Historical Eemarks. — General Description of the Anatomical Struct- ure. — Metamorphoses. — Forms. — Topography. — 1. Skin and Mucous Membranes with Pavement Epithelium. — 2. Milk Glands. — 3. Mucous Glands with Cylindrical Epithelium. — i. Lachrymal Glands, Salivary Glands, and Prostate Glands. — 5. Thyroid Glands and Ovaries. — Treatment. — Brief Eemarks about the Diag- nosis, .p. 680 CHAPTER XXI. AMPUTATIONS, EXARTICULATIONS, AND RESECTIONS. LECTUEE LI. Importance of these Operations. — Amputations and Exarticulations. — Indications. — Methods. — After-Treatment. — Prognosis. — Conical Stumps. — Artificial Limbs. — History. — Eesection of the Joints. — History. — Indications. — Methods. — After- Treatment, p. 720 Appendix: Additions from the Eighth German Edition, p. 739 Index, P- 760 LIST OF WOODCUTS. FIG. 1. Diagram of connective tissue, with capillaries, . 2. Diagram of incision, capillaries closed by blood-clots, collateral distention, 3. Diagram representing the surface of the wound united by inflammatory new formation, . . . . 3 a. Vessels from mesentery of frog, . 3 b. Development of vessels, .... 3 o. Vessels in vitreous body, .... 4. Diagram of a wound with loss of substance, . 5. Pus-cells from fresh pus, .... 6. Diagram of granulation of a wound, 7. Fatty degeneration of cells from granulations, . 7 a. Epithelium of the cornea of a frog, 8. Corneal incision three days old, 9. Incised wound twenty-four hours old, . 10. Cicatrix nine days after an incision, 11. Granulation-tissue, ..... 12. Young cicatricial tissue, .... 13. Horizontal section through the tongue of a dog, 14. Same, ten days old, ..... 15. Same, sixteen days old, ..... 16. Granulation- vessels, . . . 17. Seven-days-old wound in the lip of a dog, 17 a. Micrococcus, ..... 18. Cicatrix from the upper lip of a dog, . 19. Ends of divided muscular fibres, . 20. Regenerative processes in transversely-striated muscle, 21. Regeneration of nerves, .... 22. " " 22 a. Nerves after division, .... 23. Nodular nerve-terminations in an old stump, 24. Artery ligated in the continuity, . 25. Transverse section of a fresh thrombus, 26. Transverse section of thrombus six days old, 27. Ten-days-old thrombus, ..... 28. Completely-organized thrombus, . 29. Longitudinal section of the ligated end of an artery, 30. Portion of a transverse section of a vein, with organized thrombus 31. Artery, injected six weeks after ligation, 32. Artery, injected thirty-five months after ligation, 33. Artery, injected three months after ligation, 34. Artery wounded on the side, with clot, .... PAGE 51 52 59 60 66 67 73 75 77 78 78 83 84 84 85 86 86 87 87 103 113 114 115 116 116 117 119 120 121 122 122 123 124 125 127 127 128 135 XV111 LIST OF WOODCUTS. 35. Aneurisma traumaticum, . . 36. Varix aneurismaticus, ..... 37. Aneurisina varicosum, ..... 38. Granular and crystalline hsematoidin, 39. Detachment of dead connective tissue in contused wounds 40. Central end of a torn brachial artery, 41. Evulsed middle finger, ..... 42. Arm torn out, with scapula and clavicle, . 43. Longitudinal section of a fracture four days old, 44. Diagram of a longitudinal section of a fracture fifteen days old, 45. Diagram of a longitudinal section of a fracture twenty -four weeks old 46. Fracture, with dislocation, after twenty-seven days, 47. Old united oblique fracture, .... 48. Longitudinal section through the cortical substance, 49. Inflammatory new formation in Haversian canals, 50. Ossification of inflammatory neoplasia on the surface of the bone and in th Haversian canals, ..... 51. Artificially-injected external callus, five days old, 52. Artificially-injected transverse section, eight days old, 53. Ossifying callus on the surface of a hollow bone, 54. Detachment of a superficial piece of a flat bone, 55. Detachment of a necrosed portion of bone, 56. Fracture of a long bone with external wound, 57. Necrosis of sawed surface of femur, 58. Bullets of various styles, . . . 59. Tiemann's bullet-forceps, .... 60. Gunshot-fractures of femur and tibia, 61. Traces of lightning, ..... 62. Conjunctiva affected with catarrh, . 63. Tissue from a prepuce infiltrated from inflammation, 64. Purulent infiltration of the cutis connective tissue, 65. Purulent infiltration of the cellular membrane, 66. Vessels of the walls of an abscess, 66 a. Growth of fungus from the cornea of a rabbit, 67. Venous thrombus, ..... 68. Fever curve after amputation of the arm, 69. Fever curve after resection of carious wrist, 70. Fever curve in erysipelas, .... 71. Fever curve in septicaemia, .... 71 a. Giant cells from tubercles in various stages, 71 b. Minute tubercles in the peritoneum and on a cerebral artery 71 c. Minute tubercles on a cerebral artery, 72. Cutaneous ulcer of the leg, .... 73. Granulations of a common ulcer, 74. Caries superficial! s of the tibia, 75. Section of a piece of carious bone, 75 a. Ostitis malacissans, .... 76. Disappearance of chalky salts from periphery of bone 77. Sclerosed tibia and femur, .... 78. Point of caseous degeneration in the spinal column, . 79. Destruction of the vertebral column, 80. Total necrosis of the diaphysis of a hollow bone, 81. Total necrosis of the diaphysis of a hollow bone with detached sequestrum, 82. Total necrosis of the diaphysis of a hollow bone after removal of sequestrum PAGE 136 137 138 147 158 183 183 183 191 191 193 194 194 195 196 198 199 199 200 217 218 219 219 256 262 264 272 288 291 292 293 294 344 359 364 365 367 371 419 420 421 435 440 451 453 459 460 460 464 466 482 484 484 LIST OF WOODCUTS. XIX S3. Total necrosis of the diaphy sis of the femur, . 84. Total necrosis of the diaphysis of the tibia, 85. Necrosis of the lower half of diaphysis of femur 86. The body extracted from Fig. 85, 87. Diagram of partial necrosis of a hollow bone, . 88. Diagram of Fig. 87 in the later stages, 89. Fig. 88, after removal of the sequestrum, 90. Scapula of a dog, resected with and without periosteum 91. Eachitic malformations of the leg, 92. "Woman with extensive osteomalacia, 93. Section of knee-joint with fungous inflammation, 94. Degeneration of cartilage in fungous inflammation 95. Subchondral caries of the astragalus, 96. Atonic ulceration of cartilage from the knee-joint, 97. Diagram of the ordinary ganglion, 98. Hernial protrusions of synovial membrane, 99. Degeneration of the cartilage in arthritis deforman 100. Osteophytes in arthritis deformans, 101. Fungous inflammation of the elbow-joint, 102. Osteophytes in arthritis deformans, 103. Multiple articular bodies, 104. Band-like adhesions in a resected elbow-joint, 105. Adhesion of articular surfaces of the elbow-joint, 106. Elbow-joint anchylosed by bony bridges, . 107. Section of the shoulder-joint, 108. Section of the shoulder-joint, 109. Contraction of the fascia lata, 110. Cicatricial contractions after burns 111. Cicatricial contractions after burns 112. Subcutaneously-divided tendon, 113. Varices, .... 114. Cirsoid aneurism of the scalp, 115. Small fibroma, 116. From a myo-fibroma, . 117. Vessels from a cutis fibroma, 118. Neuroma, 119. Fibro-sarcomatous neuromata, 120. Cartilage tissue from chondromata, 121. Chondroma of the fingers, 122. Odontoma of a back tooth, 123. Section of an odontoma, . 124. Pedunculated spongy exostosis, 125. Ivory exostosis of the skull, 126. Section from an ivory osteoma, 127. Osteoma of the muscular attachments 128. Vessels from a plexiform angioma, 129. Mesh-work from a cavernous angioma 130. Tissue of granulation-sarcoma, 131. Tissue of glio-sarcoma, . 132. Tissue of a spindle-celled sarcoma, 133. Giant-cells from a sarcoma, 134. Giant-celled sarcoma with cysts, 135. Cell-globules from a sarcoma, . 136. Mucous tissue from a myxosarcoma, PAGE 485 485 486 487 487 488 488 489 496 501 506 508 509 512 528 531 535 537 537 537 543 547 548 548 549 549 565 566 566 570 577 582 619 620 621 622 622 628 630 632 632 633 634 634 635 639 640 646 646 647 648 648 649 649 XX LIST OF WOODCUTS. FIG. 137. Mucous tissue from an adenomyxoma, 138. Alveolar sarcoma from the deltoid muscle, . 139. Alveolar sarcoma from the tibia, 140. Central osteosarcoma of the ulna, 141. Section of Fig. 140, ..... 142. Central osteosarcoma of the lower jaw, 143. Section of Fig. 142, 144. Compound cystoma of the thigh, 145. Periosteal sarcoma of the tibia, .... 146. Section of Fig. 145, 147. From an adeno-sarcoma of the female breast, . 148. From the cortical layer of a hyperplastic lymphatic gland 149. Sections of a wart, ..... 150. From a mucous polypus, .... 151. Adenoma of the thyroid, . . . 152. Commencing epithelial cancer of the lip, 153. Flat epithelial cancer of the cheeks, 154. Elements of an epithelial carcinoma of the lip, 155. From an epithelial cancer of the hand, . 156. Vessels from a carcinoma of the penis, 157. Papillary formation of a villous cancer, . 158. Mammary cancer, acinous form, 159. Soft mammary cancer, ..... 160. From a mammary cancer, .... 161. Connective-tissue frame-work of a cancer of breast, 162. Cancer of breast, tubular form, 163. Cancer of the mamma from an atrophied part, . 164. Vascular net-work from a very young nodule, 165. Vascular net-work around points of softening, . 166. Connective-tissue infiltration, etc., . 167. Cellular infiltration of fatty tissue, etc., 168. Cancer of the mucous glands from nose, 169. Adenoid cancer of the rectum, . 139 a. Villous sarcoma, 139 b. Psammona, . . • 139 c. From a cerebral tumor, 139 d. Plexiform sarcoma, 139 e. From a cylindroma of the orbit, . PAGE 649 651 651 655 655 656 656 657 658 658 660 663 667 670 672 686 686 687 693 696 697 699 700 701 705 706 708 709 752 754 755 755 756 SURGICAL PATHOLOGY AND THERAPEUTICS. LECTURE I, INTRODUCTION. Relation of Surgery to Internal Medicine.— Necessity of the Practising Physician being acquainted with both. — Historical Eemarks. — Nature of the Study of Sur- gery in the German High-schools. Gentlemen : The study of surgery, which you begin with this lecture, is now, in most countries, justly regarded as a necessity for the practising physician. We consider it a happy advance that the division of surgery from medicine no longer exists, as it did formerly. The difference between internal medicine and surgery is in fact only apparent ; the distinction is artificial, founded though it be on history, and on the large and increasing literature of general medicine. In the course of this work your attention will often be called to the frequency with which surgery must consider the general state of the body, to the analogy between the diseases of the external and inter- nal parts, and to the fact that the whole difference depends on our seeing before us the changes of tissue that occur in surgical diseases, while we have to determine the affections of internal organs from the symptoms. The action of the local disturbances on the body at large must be understood by the surgeon, as well as by any one who pays especial attention to diseases of the internal organs. In short, the surgeon can only judge safely and correctly of the state of his patient when he is at the same time a physician. Moreover, the physician who proposes refusing to treat surgical patients, and to attend solely to the treatment of internal diseases, must have some surgical knowledge, or he will make the grossest blunders. Apart from the fact that the country physician does not always have a colleague at hand to whom he can turn over his surgical patients, the life of the patient often de- pends on the correct and instantaneous recognition of a surgical disease. 1 2 INTRODUCTION When blood spouts forcibly from a wound, or a foreign body has entered the windpipe, and the patient is threatened with suffocation, then surgical aid is required, and quickly too, or the patient dies. In other cases, also, the physician ignorant of surgery may do much harm by not recognizing the importance of a case ; he may allow a disease to become incurable, and by his deficient knowledge cause unspeakable injury, in a case which might have been relieved by early surgical treatment. Hence it is inexcusable for a physician obstinately to stick to the idea of only practising internal medicine ; still more inex- cusable is it, in this idea, to neglect the study of surgery : " I will not operate, because in ordinary practice there is so little operating to be done, and I am not at all suited for an operator ! " As if surgery con- sisted only in operations. I hope to give you a better idea of this branch of medicine than is conveyed by the above remark, which un- fortunately is too popular. From the fact that surgery has to deal chiefly with patent dis- eases, it certainly has an easier position in regard to anatomical diag- nosis ; but do not regard this advantage too highly. Besides the fact that surgical diseases also often lie deeply hidden, more is demanded from a surgical diagnosis and prognosis, and even in the treatment, than from the therapeutic action of internal medicine. I do not deny that in many respects internal medicine may hold a higher rank, just on account of the difficulties it has (and often so brilliantly overcomes) in localizing and recognizing disease. Very fine operation of the mind is often necessary to come to a proper conclusion, from the combination of symptoms, and the results of the examination. Physicians may point with pride to the anatomical diagnosis of diseases of the heart and lungs, where the careful student succeeds in giving as accurate a de- scription of the changes in the diseased organ as if he had it right under his eyes. How wonderful it is to gain an accurate knowledge of the morbid state of hidden organs, such as the kidneys, liver, spleen, intestines, brain, and spinal marrow, by the examination of a patient and the combination of symptoms ! What a triumph to diag- nose diseases of organs of which we do not know even the physiolo- gical function, as of the supra-renal capsules ! This is some compensa- tion for the fact that, in internal medicine, we must more frequently acknowledge the impotence of our treatment than is the case in surgery, although, from the advances in anatomical diagnosis, we have become more certain of what we can do, and of what we cannot. The irritation of the finer, cultivated portions of the mind in inter- nal medicine is, however, richly balanced by the greater certainty and clearness of diagnosis and treatment in surgery, so that the two branches of medical science are exactly on a par. And it must not INTRODUCTION. 3 be forgotten that the anatomical diagnosis — I mean the recognition of the pathological changes in the diseased organ — is only one means to the end, which is the cure of the disease. The true problems for the physician are to find out the causes of the morbid process, to prog- nosticate the course, conduct it to a favorable termination, or control it, and these are equally difficult in internal and external medicine. Only one thing more is required of the practical surgeon : this is, the art of operating. This, like every art, has its knack ; the facility of operating secondarily depends on accurate knowledge of anatomy, on practice, and on personal aptitude. This aptitude may also be culti- vated by persevering practice. Just remember how Demosthenes suc- ceeded in acquiring fluency in speaking. This knack, which is certainly necessary, has long separated sur- gery from medicine in the strict sense ; we may historically follow this separation as it constantly became more practically felt, till in this century it was finally recognized as impractical and was abol- ished. The word " chirurgery " at once expresses that originally it was regarded as entirely manual, for it comes from x EL ? an d Zpyov, which literally mean " hand-work," or, in the pleonasm of the middle ages, " hand-work of chirurgery." Little as it comes within the scope of this work to give a complete sketch of the history of surgery, it still seems to me important and in- teresting to give you a short sketch of the external and internal de- velopment of our science, which will explain to you some of the va- rious regulations affecting the so-called "medical staff" still existing in different states. A fuller history of surgery can only be of use to you hereafter, when you shall have acquired some knowledge of the value or worthlessness of certain systems, methods, and operations. Then, in the historical development of the science, especially as regards op- erative surgery, you will find the key for some surprising and for some isolated experience, also for much that is incomplete. Many things that may be necessary for the comprehension of the subjects, I shall relate to you when speaking of the different diseases ; now, I shall only present a few prominent points in the development of sur- gery and of its present position. Among the people in former times, the art of healing was inti- mately associated with religious education. The Hindoos, Arabs, and Egyptians, as well as the Greeks, considered the art of healing as a manifestation made by the gods to the priests, and then spread by tradi- tion. Philologists were not agreed as to the age of the Sanscrit writ- ings discovered not long since ; formerly their origin was placed at 1000-1400 B. c, now it is considered certain that they were written in the first century of the Christian era. The Agur-Veda (" Book of 4 INTRODUCTION. the Art of Life ") is the most important Sanscrit work for medicine ; it is the production of Smrutas. It very probably originated in the time of the Roman Emperor Augustus. The art of healing was regarded as a whole, as is indicated by the following: " It is only the combina- tion of medicine and surgery that makes the complete physician. The physician lacking knowledge of one of these branches is like a bird with only one wing." At that time surgery was without doubt by far the more advanced part of the medical art. A large number of op- erations and instruments are spoken of; still, it is truly said " the best of all instruments is the hand ; " the treatment of wounds given is simple and proper. Most surgical injuries were already known. Among the Greeks all medical knowledge at first centred in^7s- culapius, a son of Apollo, and a scholar of the Centaur Chiron. Many temples were built to iEsculapius, and the art of healing was handed down by tradition through the priests of these temples ; the number of these temples induced various schools of JEsculapides, and, although every one entering the temple as a priest had to take an oath, which has been handed down to our own times (although of late its genuineness appears rather doubtful), that he would only teach the art of healing to his successors, still, as appears from various cir- cumstances, even at that time there were other physicians besides the priests. From one part of the oath, even, it is evident that then as now there were physicians who, as specialists, confined themselves to cer- tain operations ; for it says : " Furthermore, I will never cut for stone, but will leave this operation to men of that occupation." Of the different varieties of physicians we know nothing more accurate till the time of Hippocrates ; he was one of the last of the Asklepiades. He was born 460 b. c, oh the island of Cos ; lived partly in Athens, partly in Thessalian towns, and died 377 b. c. at Larissa. "We might expect that medicine would be considered scientifically at this time, when the names of Pythagoras, Plato, and Aristotle, were shining in Grecian science ; and in fact the works of Hippocrates, many of which are still preserved, arouse our astonishment. The clear classical de- scription, the arrangement of the whole material, the high regard for the healing art, the sharp critical observations, that appear in the works of Hippocrates, and compel our admiration and respect for an- cient Greece on this branch also, clearly show that it is not a case of blind belief in traditional medical dogmas, but that there was already a scientific and elaborately perfected medicine. In the Hippocratic schools the art of healing formed one whole ; medicine and surgery were united, but there were various classes of medical practitioners ; besides the Asklepiades there were other educated physicians, as well as more mechanically instructed medical assistants, gymnasts, quacks, INTRODUCTION. 5 and workers of miracles. The physicians took scholars to train in the art of healing ; and, according to some remarks of Xenophon, there were also special army physicians ; especially in the Persian wars, they, together with the soothsayers and flute-players, had their places near the royal tent. It may be readily understood that, at a time when so much was thought of corporeal beauty, as was the case among the Greeks, external injuries would claim special attention. Hence, among physicians of the Hippocratic era, fractures and sprains were particularly studied ; still, some severe operations are treated of, as also numbers of instruments and other apparatuses. They seem to have been very backward regarding amputations ; probably the Greeks preferred dying to prolonging life after they were mutilated. The limb was only removed when it was actually dead, gangrenous. The teachings of Hippocrates could not at first be carried any fur- ther, for lack of knowledge of anatomy and physiology. It is true there was a faint effort made in this direction in the scientific schools of Alexandria, which flourished for some centuries under the Ptole- mies, and by means of which, after the wars of Alexander the Great, the Grecian spirit was spread, at least temporarily, over part of the Orient ; but the Alexandrian physicians soon lost themselves in phil- osophical systems, and only advanced the science of healing a little by a few anatomical discoveries. In this school the art of healing was at first divided into three separate parts — dietetics, internal medi- cine, and surgery. Along with Grecian culture, their knowledge of medicine was also brought to Rome. The first Roman physicians were Grecian slaves ; the freedmen among them were allowed to erect baths ; here, first, barbers and bathers became our rivals and col- leagues, and for a long time they injured the respectability of the pro- fession in Rome. Gradually the philosophically-minded took posses- sion of the writings of Hippocrates and the Alexandrians, and them- selves practised medicine, without, however, adding to it much that was new. The great lack of original scientific production is shown in the encyclopedial revision of the most varied scientific works. The most celebrated work of this nature is the " De Artibus " of Aulus Corne- lius Gelsus (from 25-30 b. c. to 45-50 a. d., in the time of the Em- perors Tiberius and Claudius). Eight books of this, " De Medicina" have come down to our time ; from these we know the state of medi- cine and surgery at that time. Valuable as are these relics from the Roman ages, they are only, as we have said, a compendium, such as is often published at the present day. It has even been denied that Celsus was a practising physician, but this is improbable ; from his writings we must, at all events, credit Celsus with using his own judg- ment. The seventh and eighth books, which treat on surgery, could not 6 INTRODUCTION. have been written so clearly by any one who had no practical knowl- edge of his subject. Hence we see that, since the time of Hippo crates and the Alexandria school, surgery, especially the operative part, had made no great progress. Celsus speaks of plastic opera- tions, of hernia, and gives a method of amputation which is still occa- sionally employed. One part, from the seventh book, where he speaks of the qualifications of the perfect surgeon, is quite celebrated, as it is characteristic of the spirit which reigns in the book ; I give it to you : " The surgeon should be young, or at least little advanced in age, with a hand nimble, firm, and never trembling ; equally dexter- ous with both hands ; vision, sharp and distinct ; bold, unmerciful, so that, as he wishes to cure his patient, he may not be moved by his cries to hasten too much, or to cut less than is necessary. In the same way let him do every thing as if he were not affected by the cries of the patient." Claudius Galenus (131-201 a. d.) must be regarded as a phe- nomenon among the Roman physicians; eighty-three undoubtedly genuine medical writings of his have come down to us. Galen re- turned again to the Hippocratic belief, that observation must form the foundation of the art of healing, and he advanced anatomy great- ly; he made dissections chiefly of asses, rarely of human beings. Galen's anatomy, as well as the entire philosophical system into which he brought medicine, and which seemed to him even more im- portant than observation itself, has stood firm over a thousand years. He occupies a very prominent position in the history of medicine. He did little for surgery in particular ; indeed, he practised it little, for in his time there were special surgeons, either gymnasts, bathers, or barbers, and so unfortunately surgery was handed down by tradition as a mechanical art, while internal medicine was, and long remained, in the hands of philosophic physicians; the latter knew and com- mented freely on the surgical writings of Hippocrates, the Alexandri- ans, and Celsus, still they paid little attention to surgical practice. As we are only giving a faint sketch, we might here skip several cen- turies, or even a thousand years, during which surgery made scarcely any progress, indeed retrograded occasionally. The Byzantine era of the empire was particularly unfavorable to the advance of science, there was only a short flickering up of the Alexandria school. Even the most celebrated physicians of the later Roman times, Antyllus (in the third century), Oribasius (326-403 a. d.), Alexander of Tralles (525-605 A. d.), Paulus of ^Jgina (660), did relatively little for sur- gery. Some advance had been made in the position and scholarly at- tainments of physicians ; under Nero there was a gymnasium ; under Hadrian an athenaeum, scientific institutions where medicine also was INTRODUCTION. 7 taught; under Trajan, there was a special medical school. Military medical service was attended to among the Romans, and there were special court physicians, " archiatri palatini," with the title of " per- fectissime," " eques," or * comes archiatrorum," just as, among the Germans, " Hofrathe," " Geheimrathe," " Leibarzte," etc. That, as a result of the fall of science in the Byzantine reign, the art of healing did not totally degenerate, is due to the Arabians. The wonderful elevation that this people attained under Mohammed, after the year 608, aided in preserving science. The Hippocratic knowledge of medicine, with the later additions to it, passed to the Arabians through the Alexandrian school, and its branches in the Orient, the schools of the Nestorians ; they cherished it till their power was de- molished by Charles Martel, and returned it to Europe by way of Spain, though somewhat changed in form. Ithazes (850-932), Avi- cenna (980-1037), Alhucasis (f 1106), and Avenzoar (f 1162), are the most celebrated, and for surgery the most important, of the Arabian physicians whose writings have been preserved ; the writings of the latter are the most important for surgery. Operative surgery suffered greatly from the dread the Arabians had of blood, which was partly due to the laws of the Koran ; it caused the employment of the ac- tual cautery to an extent that we can hardly comprehend. The dis- tinction of surgical diseases and the certainty of diagnosis had de- cidedly increased. Scientific institutions were much cultivated by the Arabians ; the most celebrated was the school of Cordova ; there were also hospitals in many places. The study of medicine was no longer chiefly private, but most of the students had to complete their studies at some scientific institution. This also had its effect on the nations of the West. Besides Spain, Italy was the chief place where the sciences were cultivated. In southern Italy there was a very cele- brated medical school at Salerno / it was probably founded in 802 by Charles the Great, and was at its zenith in the twelfth century ; according to the most recent ideas, this was not an ecclesiastical school, but all the pupils were of the laity. There were also female pu- pils, who were of a literary turn ; the best known among these was Trotula. Original observations were not made there, or at least to a very slight extent, but the writings of the ancients were adhered to. This school is also interesting from the fact that it is the first cor- poration that we find having the right to bestow the titles " doctor " and " magister." Emperors and kings gradually took more interest in science, and founded universities; thus universities were founded in Naples in 1224, in Pavia and Padua in 1250, in Paris in 1205, in Salamanca in 1243, in Prague in 1348, and they were invested with the right of 3 INTRODUCTION. conferring academical honors. Philosophy was the science to which most attention was paid, and for a long time Medicine preserved her philosophical robe in the universities ; in some cases they adhered to Galen's system, in others to the Arabian or to new medico-philo- sophical systems, and registered all their observations under these heads. This was the great obstacle to the progress of the natural sciences, a mental slavery, from which even men of intellect could not free themselves. The anatomy of Mondino de Imzzi (1314) differs very little from that of Galen, in spite of the fact that the author bases it on dissections he made of some human bodies. In surgery there were no actual advances ; Lanfranchi (f 1300), Guido of Gauli- aco (beginning of the fourteenth century), Branca (middle of the fifteenth century), are a few of the noteworthy surgeons of those times. Before passing to the flourishing state of the natural sciences and of medicine in the sixteenth century, we must review briefly the composi- tion of the medical profession in the times of which we have been speaking, as this is important for the history. First, there were philo- sophically educated physicians either lay or monk, who had learned medicine in the universities or other schools ; i. e., they had studied the old writings on anatomy, surgery, and special medicine ; they prac- tised, but paid little attention to surgery. Another seat of learning was in the cloisters ; the Benedictines especially paid a great deal of attention to medicine and also practised surgery, although the supe- riors disliked to see this, and occasionally special dispensation had to be obtained for an operation. The regular practising physicians were sometimes located, sometimes travelling. The former were usually educated at scientific schools and received permission to practise on certain conditions. In 1229, the emperor Frederick II. published a law that these physicians should study logic (that is, philosophy and philology) three years, then medicine and surgery five years, and then practise for some time under an older physician; before receiving permission to practise independently, or, as an examiner lately said, of physicians who had just received their degree, " till they were let loose on the public." Besides these located physicians, of whom a great part were " doctor " or " magister," there were many " travelling doctors," a sort of " travelling student " who went through the market- towns in a wagon with a merry Andrew, and practised solely for money. This genus of the so-called charlatans, which played an im portant part in the poetry of the middle ages, and is still gleefully greeted on the stage by the public, carried on a rascally trade in the middle ages ; they were as infamous as pipers, jugglers, or hangmen ; even now these travelling scholars are not all dead ; although, in the nineteenth century, they do not ply their trade in the market-place, but INTRODUCTION. 9 ji the drawing-rooms as workers of miracles, especially as cancer-doc- tors, herb-doctors, somnambulists, etc. Let us now inquire the rela- tion, of those who practised surgery, to the above company. This branch of medicine was occasionally resorted to by almost all of the above ; still there were special surgeons, who united into guilds and formed honorable societies ; they received their practical knowledge first from a master, under whom they studied, and subsequently from books and scientific institutions. Surgical practice was chiefly confined to these persons, who were mostly located, but sometimes travelled about as " hernia doctors," " operators for stone," " oculists," etc. "We shall become acquainted with some excellent men among these old mas- ters of our art. Besides the above, surgery was also practised by the " bathers," and later by " barbers " also, as it was among the Romans, and they were permitted by law to attend to " minor surgery," e. g., they could cup, bleed, treat fractures, sprains, etc. It will be readily understood that some strife would arise about the various and some- times indefinite privileges of these different grades of physicians, especially in large cities, where all classes of them were collected. This was particularly the case in Paris. The surgical society there, the " College de St. Come," claimed the same privileges as members of the medical faculty ; they were particularly desirous for the Bacca- laureate and Licentiate. The " Society of Barbers and Bathers," again, wished to practise any part of surgery, just like the members of the College de St. Come. To gall the surgeons, the members of the fac- ulty supported the claims of the barbers, and, in spite of mutual tempo- rary compromises, the strife continued ; indeed, we may say that it still continues, where there are pure surgeons (surgeons of the first class and barbers) and pure physicians. It is only since about 1850 that the distinction was done away with in almost all the German states, and neither chirurgi puri nor medici puri were made, but only physi- cians who practised medicine, surgery, and obstetrics. To finish the question of external rank, we may notice that in Eng- land alone there is still a tolerably well-marked dividing-line be- tween surgeons and physicians, especially in the cities, while in the country " general practitioners " attend to both medical and surgical cases, and have an apothecary-shop even at the same time. In Germany, Switzerland, and France, circumstances often cause a physician to have more surgical than medical practice ; but the med- ical staff legally consists of physicians and assistants or barber-sur- geons, who, after examination, are licensed to cup, bleed, etc. This arrangement has finally gone into effect in the army also, where the so-called company surgeon, with the rank of sergeant, formerly had a miserable time under the battalion and regimental physicians. 10 INTRODUCTION. In again taking up the thread of the historical development of surgery, as we enter the period of " Renaissance " in the sixteenth century, we must first think of the great change which then took place in almost all sciences and arts, on account of the Reformation, the discovery of printing, and the awakening spirit of criticism. Obser- vation of Nature began to reassume its proper position and gradually but slowly to free itself from the fetters of the schools ; investigation after truth again assumed its claims to being the only true way to knowledge — the Hippocratic spirit was again awakened. It was chiefly the new investigations, we might almost say the rediscovery, of anatomy and the subsequent restless progress of this branch, that levelled the road. Vesal (1513-1564), Miopia (1523-1562), and Fus- tachio (f 1579), were the founders of our present anatomy ; their names, like those of many others, are known to you from the appellations of certain parts of the body. The celebrated Bombastus Theophrastus Paracelsus (1493-1554) was among the first to criticise the prevailing Galenical and Arabic systems, and to claim observation as the chief source of medical knowledge. Finally, when William Savvey (1578-1658) discovered the circulation of the blood, and Aselli (1581- 1626) discovered the lymphatic vessels, the old anatomy and physiol- ogy were obliged to give place to modern science, which thence grad- ually progressed to our times. Even then it was a long time before practical medicine escaped in the same way from philosophic thral- dom. System was founded on system, and the theory of medicine constantly varied to correspond to the prevailing philosophy. We may claim that it was not till pathological anatomy made its great ad- vances in the present century that practical medicine acquired the firm anatomico-physiological foundation on which the whole structure now moves, and which forms a strong protection against all philosoph- ical medical systems. Even this anatomical direction, however, may be pushed too far and too exclusively. "We shall speak of this hereafter Now we will turn our attention to the scientific development of surgery from the sixteenth century to our times. It is an interesting feature of that time that the advance of practi- cal surgery depended more on the surgical societies than on the learned professors of the universities. German surgeons had to seek their knowledge mostly in foreign universities, but part of it they worked out for themselves independently : Heinrich von JPfolspru?idt, a German friar (born the beginning of the fifteenth century), Hieron- ymus Brunschwig (born 1430), Hans von Gersdorf (about 1520), and Felix Wiirtz (fl576), surgeons at Basel, are first among these. We have writings of all of them ; Felix WlXrtz seems to me the most original of them ; he had a sharp, critical mind. Fabry von Hilden INTRODUCTION. 11 (1560-1634), of Berne, and Gottfried Purman, of Halberstad and Breslau (about 1679), were men of great acquirements ; their writ- ings show a high appreciation for their science, they fully recognized the value and imperative necessity of exact anatomical knowledge, and by their writings and private instruction imparted it to their scholars as much as possible. Among the French surgeons of the sixteenth and seventeenth cen- turies, Ambroise Pare (1517-1590) is most prominent ; originally only a barber, from his great services, he was made a member of the So- ciety of St. C6me; he was very active as an army surgeon, was often called from home on consultations, and at last resided in Paris. Par'e advanced surgery by what was for those times a very sharp criticism of treatment, especially of the enormous use of problematical remedies ; some of his treatises, e. g., on the treatment of gun-shot wounds, are perfectly classical; he rendered himself immortal by the introduction of ligature for bleeding vessels after amputation. Pare, as the reformer of surgery, may be placed by the side of Vesal, as reformer of anatomy. The works of the above individuals, besides some others more or less gifted, held their place into the seventeenth century, and it is only in the eighteenth that we find any important advances. The strife between the members of the faculty and those of the College de St. Come still continued in Paris ; the great celebrity of the latter had more effect than the professors of surgery. This was finally prac- tically acknowledged in 1731 by the foundation of an "Academy of Surgery," which was in all respects an analogue of the medical faculty. This institution soon advanced to such a point that it ruled the sur- gery of Europe almost a century ; nor was this an isolated cause ; it formed part of the general French influence, of that universal mental dominion which the " grande nation " cannot even yet forget when German science has forever eclipsed French influence, after the con- flicts of 1813-'14. The men who then stood at the head of the movement in surgical science were Jean Louis Petit (1674-1768), Pierre Jos. Desault (1744-1795), Pierre Francois Percy (1754- 1825), and many others in France; in Italy, Scarpa (1748-1832) was the most active. Even in the seventeenth century, surgery was highly developed in England, and in the eighteenth century it attained great eminence under Percival Pott (1713-1768), William and John Hunter (1728-1793), Benjamin Bell (1749-1806), William Chesel- den (1688-1752), Alexander Monro (1696-1767), and others. Among these was John Hunter, that great genius, as celebrated for anatomy as surgery; his work on inflammation and wounds still forms the basis of many of our present views. In comparison with these, the names of the German surgeons of 12 INTRODUCTION. the eighteenth century are insignificant ; most of them brought theii knowledge from Paris, and added little that was original : Lorenz Seister (1683-1758), John Ulrich Bilguer (1720-1796), and Chr. Ant. Theden (1719-1797), are relatively the most important. Ger- man surgery only obtained greater eminence with the commencement of the present century. Carl Caspar von Siebold (1736-1807), and August Gottlob Bichter (1742-1812), were distinguished men ; the former served as professor of surgery in Wurzburg, the latter in Got- tingen ; some of Hichter' s writings are valuable even now, especially his little book on rupture. On the threshold of our century you see professors of surgery again in the foreground, where they subsequently maintained their position, because they aciaially practised surgery. A predecessor of old Bichter, as professor of surgery at Gottingen, the celebrated Al- bert Sailer (1708-1777), at once physiologist and poet, one of the last encyclopaedists, says, " Etsi chirurgiae cathedra per septemdecim an- nos mihi concredita fuit, etsi in cadaveribus dificilimas administrationes chirurgicas frequenter ostendi, non tamen unquam vivum hominem incidere sustinui, nimis ne nocerem veritus." To us this seems scarcely Credible, so great is the change wrought by a hundred years. Even at the commencement of this century the French surgeons re- mained at the helm ; Boyer (1757-1833), Delpech (1776-1832), and par- ticularly Dupuytren (1777-1835), and Jean Dominique Larrey (1776- 1842), were almost undisputed authorities in their line. Besides them there arose in England the unimpeachable authority, Sir Astley Coop- er (1768-1841). Larrey ', the constant companion of Napoleon I., left a large number of works ; you will hereafter read his memoirs with great interest. Dupuytren was chiefly celebrated for his excellent clinical lectures. Cooper's monographs and lectures will fill you with astonishment. Translations of the writings of the above French and English surgeons first aroused German surgery ; but soon the subject was gone into most profoundly by original workers. The men who induced the German revolution in surgery were, among others, Vincenz von Kern, of Vienna (1760-1829), John JSTep. Bust, of Berlin (1775- 1840), Philipp von Walther, of Munich (1782-1849), Carl Ferd. von Graefe, of Berlin (1787-1840), Conr. Joh. Martin Langenbeck, of GQttingen (1776-1850), Joh. Friedrich Dieffenbach (1795-1847), Cajetan von Textor (1782-1860), of Wurzburg. The nearer we approach the middle of our century, the more the rugged bounds of nationality disappear from the domains of surgery. With increased means of communication, all advances in science spread with breathless haste to all parts of the civilized world. Num- berless writings, national and international medical congresses, and INTRODUCTION. 13 personal intercourse, have brought radical changes to the surgeons as well as to others. A generation of surgeons, upon whose works the profession looks with honor, appears to be now dying out; I mean men such as Stanley (1791-1862), Lawrence (1783-1867), and Brodie (1783-1862), in England; JRoux (1780-1854), Bonnet (1809- 1858), Leroy (1798-1861), Malgaigne (1806-1865), Civiale (fl867), Jobert (1799-1868), and Velpeau (1795-1867), in France; Seutin (1793-1862), in Belgium ; Valentine Mott (1785-1865), in America; Wutzer (1789-1863), Schuh (1804-1865), and others, in Germany. From our own generation also we have some losses to mourn, espe- cially the irreparable death of the gifted, indefatigable investigator O. Weber (1827-1867) ; of the excellent Follin (-1867), one of the most solid of modern French surgeons ; of Middeldorpf (1824-1868), the celebrated inventor of galvano-caustic operations. Among the living we might name many on whose shoulders rests the growing generation of German surgeons, but they do not yet belong to his- tory. But there is one point I must not leave unmentioned, that is, the introduction of pain-quelling remedies into surgery. The nineteenth century may be proud of the discovery of the practical use of sulphu- ric ether and chloroform as anaesthetics in all sorts of operations. In 1846 came from Boston the first news that Morton the dentist, at the suggestion of his friend Br. Jackson, had, in extracting teeth, em- ployed inhalations of sulphuric ether, pushed to complete anaesthesia, with perfect success. In 1859, Simpson, professor of obstetrics in Ed- inburgh, instead of ether, introduced in surgical practice chloroform, which acts still better, which, after various trials with other similar substances, still preserves its reputation. Thanks ! in the name of suffering humanity, a thousand thanks to these men ! In continuation of my previous remarks regarding German sur- gery, I will simply add that at present it stands at least equal to that of other nations, and is perhaps even superior to that of France at the present time. To perfect ourselves in the science of surgery, we no longer need to visit Paris. But, of course, it is nevertheless desirable for every physician to enlarge his experience and observation by visit- ing foreign lands. In the scientific as well as in the practical part of surgery, and of medicine generally, England is now more advanced than any other country. In America also great advances have been made in practical surgery. From the time of Hunter to the present day, English surgery has about it something noble. Surgery owes its great revolution in the nineteenth century to its attempt to unite all medical knowledge in itself ; the surgeon who succeeds in this, and also masters the entire mechanical side of the art, may feel that he has attained the highest ideal in medicine. 14 INTRODUCTION. Before entering on our subject, I will add a few remarks about the study of surgery as it is, or is said to be, pursued in our high- schools. In the four years' course of medical study which is customary in German universities, I would advise you not to begin surgery before the fifth semestre. You often desire to escape the preliminary studies and plunge at once into the practical. It is true, this is somewhat less the case since courses on anatomy, microscopy, physiology, chem- istry, etc., have been started in the high-schools, where you have some practice ; nevertheless, there is still too much haste to enter the clin ics. It is true, it is one way of gaining experience from the very start ; you consider it more interesting than bothering yourselves at first with things whose connection with practice you do not exactly un- derstand. But you forget that a certain school of observation must be gone through with, to enable us to make actually useful what we know. If any one just released from school should at once enter the hospital as a student, he would be in the same position as a child entering the world to collect knowledge. Of what use are the ex- periences of the child for his subsequent life among men ? How late it is before we see the true use of the most common observations of daily life ! Hence, to wade through the entire development of medi- cine in this empirical manner would be a long, tedious labor, and only a very gifted, industrious man would learn any thing in this way. After having made numerous errors, we must not place too great a value on " experience " and " observation," if by these terms we mean no more than the laity do. It is an art, a talent, a science, to observe critically, and from our observations to draw correct conclusions for our " experience ; " this is the strong point of the empiric ; the laity know experience and observation in the vulgar, not in the scientific sense, and they value the so-called experience of an old shepherd as high as, sometimes higher than, that of a physician ; unfortunately, the public are sometimes right on this point. But enough ! when a physician or any one else displays his experience and observation be- fore you, look sharply to see whether he has any brains. In making these remarks against pure empiricism, we do not by any means intend to say that you must be theoretically acquainted with all medicine before studying it practically, but you should bring a certain knowledge of the fundamental principles of natural science with you into the clinic. It is absolutely necessary to have a general idea of what you are to expect ; and you must know something of the tools before seeing them used, or taking them in your hands. In other words, you should know the outlines of general pathology and therapeutics, as well as of materia medica, before going to the bed- INTRODUCTION. 15 side of the patient. General surgery is only one part of general pathology, hence you should study the latter before entering the sur- gical clinic. First, you should gain a clear understanding of normal histology, at least of its general parts; pathological anatomy and histology should come with general surgery, about the fifth semestre. General surgery, the subject of the present lectures, is a part of general pathology, as we have already stated ; but it is nearer to practice than the latter. It comprises the study of wounds, inflam- mations, and tumors of the external parts of the body, or of those parts that may be handled from without. Special or topographical surgery occupies itself with the surgical diseases of different parts of the body, so that the most different tissues and organs are to be con- sidered according to their location ; for instance, while we here treat only of wounds, of their mode of recovery and treatment in general, special surgery treats of wounds of the head, breast, and abdomen, paying special attention to the participation of the skin, bones, and viscera. Were it possible to pursue the study of surgery for several years in a large hospital, and could careful clinical consid- eration of individual cases be carried on continuously with the regular studies, it would probably be unnecessary to treat of special surgery in separate systematic lectures. But, since there are many surgical dis- eases that perhaps may not occur for years even in a large hospital, but which should be known to the surgeon, the lectures on special surgery are by no means superfluous, if they are short and to the point. During my student days I occasionally heard the remark : " Why should I go to listen to special surgery and pathology ? I can read them more conveniently in my room." This may be all true, but un- fortunately it is rarely done, unless in the final semestres, when exam- ination is approaching. This reasoning is false in another respect also : the viva vox of the teacher, as old Langenbeck, in Gftttingen, used to say (and he had a viva vox in the best sense of the word), the winged word of the teacher is, or should be, more exciting and effective than what is read, and the accompanying demonstrations of diagrams, preparations, experiments, etc., should render the lectures on practical surgery and medicine particularly valuable for you. I attach great value to demonstration in medical instruction, for I know by experience that this kind of teaching is most exciting and per- manent. Besides these two sets of lectures on general and special surgery you have to practise operations on the cadaver ; this you may post- pone to the last semestres. I always like students to take their course in operations in the sixth or seventh semestres, along with their special surgery, so that I may give them the opportunity of oc- 10 INTRODUCTION. casionally operating, or even of amputating, under my direction. It gives courage in practice, if one has during student-life performed op- erations on the living subject. When you have followed the lecture? on general surgery, you may enter the surgical clinic, and there, in the seventh and eighth semestres, openly give an account of your knowledge in special cases, and accustom yourselves to collecting your ideas rapidly, learn to distinguish the important from the unim- portant, and to learn generally in what practice really consists. You will thus learn the points where your knowledge is deficient, and may perfect yourselves by persevering study. When you have thus com- pleted the legal time of your studies, passed your examination, and have increased your medical knowledge by a few months or a year in various large hospitals at home or abroad, you will be in condition to appreciate the surgical cases turning up in practice. But, if you wish to devote special attention to surgery and operating, you are still far from the goal : then you must become accustomed to operating on the cadaver, enter a surgical ward as assistant for a year or two, un- tiringly study monographs on surgical subjects, perseveringly write out cases, etc. — in short, follow out the practical school from the lowest step. You must be fully acquainted with hospital service, even with the duties of the nurses ; in short, you should know practically even the most minute things appertaining to the care of patients, and should even perform the duties yourselves occasionally, so that you may be fully master of the entire medical service intrusted to you. You see there is much to do and to learn : with patience and perse- verance you will accomplish it all ; but these virtues are necessary to the study of medicine. " Student " comes from " to study ; " hence you must study faith- fully ; the teacher indicates to you what he considers the most impor- tant ; he may stimulate you in various directions ; what he gives you as positive may, it is true, be carried home in black and white, but, to cause this positive knowledge to live in you and become your mental property, you must depend on your own mental efforts, which form the true " study." When you conduct yourself as a passive receptacle, you may, it is true, acquire the name of a very " learned person," but, if you do not awake your knowledge into life, you will never become a good " practising physician." Let what you see enter your mind fully, warm you up, and so occupy your attention that you must think of it frequently, then the true pleasure and appreciation of this mental labor will fill you. Goethe, in a letter to Schiller, aptly says : " Pleas- ure, comfort, and interest in the affairs of life, are the only realities ; all else is vanity and disappointment." CHAPTER I. SIMPLE INCISED WOUNDS OF THE SOFT PARTS. LECTURE II. Mode of Origin and Appearance of these "Wounds. — Various Forms of Incised Wounds. — Appearance during and immediately after their Occurrence. — Pain, Bleeding.— Varieties of Haemorrhage ; Arterial, Venous. — Entrance of Air through Wounded Veins. — Parenchymatous Haemorrhage. — Hsemorrhagic Diathesis. — Haemorrhage from the Pharynx and Eectum. — Constitutional Effects of Severe Haemorrhage. The proper treatment of wounds is to be regarded as the most important requirement for the surgeon, not only on account of the frequency of this variety of injury, but because we so often inten- tionally make them in operating, even when operating for something that is not itself dangerous to life. Hence we are answerable for the healing of the wound, to as great an extent as it is possible by expe- rience to judge of the danger of an injury. Let us commence with incised wounds. Injuries caused by sharp knives, scissors, sabres, cleavers, hatchets, etc., represent pure incised wounds. Such wounds are usually recog- nizable by the regular sharp borders, where we see the smooth-cut surface of the unchanged tissue ; should the instruments be blunt, by very rapid motion they may still cause quite a smooth incised wound, while by slowly entering the tissue they would give the edges of the wound a ragged appearance ; occasionally, the variety of the injury does not become evident till the wound is healing, for wounds made with sharp instruments heal more readily and quickly (for reasons to be given hereafter) than those caused by the slow entrance of dull knives, scissors, etc. Rarely a perfectly blunt body makes a wound exactly like an incised one. . This may occur from the skin being torn through by force ap- plied through a blunt object, at a point where it lies over the bone. Thus you will not unfrequently see scalp-wounds resembling incised 2 18 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. wounds, although they may have been due to a blow from a blunt body, or from striking the head against a stone, beam, etc. ; similar smooth wounds of the skin also occur on the hand, especially on the volar sur- face. Sharp angles of bone may so divide the skin from within that it will look as if cut through, as, for instance, when one falls on the crest of the tibia, and it divides the skin from within outward. As may be readily understood, sharp splinters of bone perforating the skin may also make wounds with smooth surfaces. Lastly, the open- ing of exit of a bullet-wound, i. e., of the canal which represents the passage of a bullet, may sometimes be a sharp slit. The knowledge of these points is important, for a judge may ask you if a wound has been caused by this or that instrument, in this or that manner, points which may greatly affect the bearings in a crimi- nal suit. Hitherto we have only considered wounds made with a blow or stroke. But, by repeated cuts on a wound, the edges may acquire a hacked appearance, and thus the requirements for recovery may be very much changed. For the present, we leave such wounds out of consideration ; their mode of recovery and treatment is just the same as that in contused wounds, unless they can be artificially converted into simple incised wounds by paring off the jagged edges. The various directions in which the cutting instrument enters the body generally makes little difference, unless the direction be so oblique that some of the soft parts are detached in the form of a more or less thick flap. In these Jlap-wounds, the width of the bridge, uniting the half-separated portion with the body, is important, because on this depends the question as to whether circulation of blood can continue in this flap, or if it has ceased, and the detached portion is to be re- garded as dead. Flap-wounds are chiefly due to cuts, but may also arise from tearing ; they are very frequent in the head, where part of the scalp is torn off by a hard blow. In other cases a portion of the soft parts may be entirely cut out ; then we have a wound with loss of substance. By penetrating wounds we mean those by which one of the three great cavities of the body or a joint is opened ; they are most fre- quently due to stabs or gun-shot injuries, and may be complicated by wounds of the viscera or bones. By the general terms longitudinal and diagonal wounds we of course mean those corresponding to the long or diagonal axes of the trunk, head, or extremities. Diagonal or longi- tudinal wounds of the muscles, tendons, vessels, or nerves, are of course those dividing these parts longitudinally or diagonally. The symp- toms in the person wounded, induced more or less directly by the wound, are, first, pain ; then, bleeding and gaping of the wound. SYMPTOMS— PAIN. 19 As - all the tissues, not excepting the epithelial and epidermoid, are supplied with sensory nerves, injury at once causes pain. This pain varies greatly with the nerve-supply of the wounded part, and with the sensitiveness of the patient to pain. The most sensitive parts are the fingers, lips, tongue, nipples, external genitals, and about the anus. Doubtless, each of you knows from experience the character of the pain from a wound, as of the finger. The division of the skin is the most painful part ; injury of the muscles and ten- dons is far less so ; injury of the bone is always very painful, as you may find from any one that has recovered from a fracture; it has also been handed down to us from the times when amputations were made with- out chloroform, that sawing the bone was the most painful part of the operation. The mucous membrane .of the intestines, on being irri- tated in various ways, shows very little sensitiveness, as has been occa- sionally observed on man and beast ; the vaginal portion of the ute- rus also is almost insensitive to mechanical and chemical irritation ; occasionally, it may be touched with the hot iron, as is done in treat- ing certain diseases of this part, without its being felt by the patient. It appears that the nerves requiring a specific irritation, as the nerves of special sense, are accompanied by few if any sensory fibres. The relation of the sensory nerves of touch to the sentient nerves in the skin cannot be regarded as decided, or whether there be any decided difference between them. In the nose and tongue, we have sensory and sentient nerves close together, so that in both parts, besides the specific sense peculiar to the organ, pain may also be per- ceived. The white substance of the brain, although containing many nerves, is without feeling, as may be seen in many severe injuries of the head. The division of nerve-trunks is the severest of all inju- ries. Some of you may remember the pain from rupture of a dental nerve on extraction of a tooth. Severing of thick nerve-trunks must cause overpowering pains. Sensitiveness to pain appears peculiar to individuals. But you must not confound this with various exhibitions of pain, and with the psychical power of suppressing, or at least limiting, this exhibition ; the latter depends on the strength of will, as well as on the temperament, of the individual. Vivacious persons display their pain, as well as their other feelings, more than phlegmatic persons. Most persons maintain that crying, as well as the instinctive powerful tension of all the musdes, especially of the masseters, gritting the teeth, etc., renders the pain more endurable. Personally, I have not been able to verify this statement, and I think it must be a mistake of the patients. Strong will in the patient may do much to suppress the show of pain. I well remember a woman in the GOttingen clinic, when I was a student, who, without chloroform, had the whole upper 20 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. jaw removed for a malignant tumor, and, during this difficult and painful operation, she did not once cry out, although several branches of the trifacial nerve were divided. Women generally stand suffer- ing better and more patiently than men. But the necessary exercise of psychical strength not unfrequently causes subsequent fainting, or excessive physical and psychical relaxation, of longer or shorter du- ration. You will certainly meet persons who, without any exercise of will, show so little pain from severe injury that we can only be- lieve that they really feel pain less acutely than others ; I have ob- served this most in flabby sailors, in whom all the sequelae of the injury are also generally very insignificant. The quicker the wound is made, and the sharper the knife, the less the pain ; hence, in large and small operations, it has always seemed, and very correctly too, for the advantage of the patient, that the incisions should be made with certainty and rapidity, par- ticularly in dividing the skin. The feeling in the wound, immediately after its reception, is a peculiar burning. It can scarcely be termed any thing but the feel- ing of being wounded ; there are a number of provincialisms for it — in Northern Germany, for instance, they say " the wound smarts." Only when a nerve is compressed by something in the wound, twisted or irritated in some way, there are severe neuralgic pains immedi- ately after the injury ; if these do not soon cease spontaneously, or after examination of the wound and removal of the local cause, if possible, they should be arrested by the exhibition of some internal remedy ; otherwise, they will induce and keep up a state of excite- ment in the patient that may increase to maniacal delirium. To avoid the pain in operations, we now always use anaesthet- ics; this subject will be treated of in the course on operations. Recently ether has come more into use on account of the number of deaths from chloroform. I now use a composition of 3 parts chloro- form, 1 sulphuric ether, and 1 absolute alcohol, which seems less dangerous than chloroform alone. In England, for some years, Spencer Wells, among others, has used and recommended bichloride of methyline, claiming that it acts as quickly as, and is less dan- gerous than, chloroform. Local anaesthetics, which have for their object temporary blunting of the pain in the part to be operated on, by application of a mixture of ice and saltpetre, or salt, have been again abandoned, or rather they have never been generally received. Recently these attempts have again acquired a general interest, as it seemed that a suitable method of local anaesthesia had at last been found. An English physician, Richardson, constructed a small apparatus, by which a stream of pure ether [or, better, rhigo- SYMPTOMS— HEMORRHAGE. 21 line] spray is for a time blown against one spot in the skin, and such cold is here induced that all sensation is lost. After procuring some of this ether (hydramylather) from England, I was satisfied of its perfect action. In a few seconds the skin becomes chalky white, and absolutely without sensation ; but the effect hardly extends through a moderately thick cutis; and, if the ether be still blown against the cut surface, the frozen tissues cannot be distinguished from each other, and the knife, being coated with ice, will no longer cut. Hence, even in this more perfect form, local anaesthesia can only be used advantageously in a few minor operations. My former dread, that healing of the wound would be essentially interfered with by this freezing of the part, has been shown by experience to be groundless. For quelling the pain, and as a hypnotic, immediately after extensive injuries or operations, there is nothing better than a quarter of a grain of muriate or acetate of morphia ; this quiets the patient, and, even if it does not make him sleep, he feels less pain from his wound. Quite recently hydrate of chloral ( 3 ss— 3 j, in half a glass of water) has been used ; its narcotic action was discovered by Liebreich, 1869. Its effect is essentially hypnotic, but very uncer- tain ; it cannot supplant chloroform, but is a decided acquisition to our materia medica. Locally, for the relief of pain, we employ cold in the shape of cold compresses, or bladders filled with ice, applied to the wound. We shall refer to this under the treatment of wounds. Lastly, we may give hypodermic injections. If, with a very fine syringe, furnished with a lance-shaped, sharp canula, which may be thrust readily through the skin, we inject a solution of -J-J of a grain of acetate or muriate of morphia, this remedy will exercise its nar- cotic effect at first locally on the nerves it comes in contact with, and then on the brain, as the solution is absorbed and enters the blood. Of late, this mode of employing morphia has been exceedingly popu- lar ; immediately after an operation, or severe injury, such an injec- tion is given, and the pain is at once arrested. In a pure incised or punctured wound, haemorrhage is a second im- mediate symptom ; its extent depends on the number, size, and variety of the divided vessels. At present we shall only speak of haemorrhage from tissues previously normal, and distinguish capillary, parenchyma- tous, arterial, and venous haemorrhages, which must be considered sep- arately. As is well known, the different parts of the body vary greatly in vascularity, especially in the number and size of the capillaries. In spots of equal size the skin has fewer and smaller capillaries than most 22 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. mucous membranes ; it also has more elastic tissue and muscles, bjr which (as we may feel and see in the cold and so-called goose-flesh) the vessels are more readily compressed than they are in the mucous membranes, which are poor in elastic and muscular tissue ; hence simple skin-wounds bleed less than those in mucous membranes. Haemor- rhages from the capillaries alone cease spontaneously if the tissue be healthy, because the openings of the vessels are compressed by con- traction of the wounded tissue. In diseased parts, which do not con- tract, even haemorrhage from dilated capillaries may be very consider- able. Haemorrhage from the arteries is readily recognized, on the one hand, because the blood flows in a stream, which sometimes clearly shows the rhythmical contractions of the heart ; on the other, by the bright-red color of the blood. If there be impaired respiration, this bright-red color may change to a dark hue ; thus, in operations on the neck, performed to prevent threatening suffocation, and in deep anaes- thesia, dark or almost black blood may spurt from the arteries. The amount. of blood escaping depends on the diameter of the totally- divided artery, or on the size of the opening in its wall. You must not, however, believe that the stream of blood corresponds exactly to the size of the artery ; it is usually much smaller, for the calibre of the artery generally contracts at the point of division ; only the larger arteries, such as the aorta, carotids, femoral, axillary, etc., have so little muscular fibre that they contract, in their circumference at least, to a scarcely perceptible extent. In very small arteries, this con- traction of the cut vessel has such an effect that, from the increased friction, the blood flows from them without spurting or pulsating ; in- deed, in very small arteries, this friction may be so decided that the blood flows with difficulty and very slowly, and soon coagulates, so that the haemorrhage is arrested spontaneously. The smaller the diameter of the arteries becomes, from diminution of the amount of blood in the body, the more readily haemorrhage will be arrested spon- taneously, while otherwise it would have to be arrested artificially. Hereafter, you will often have occasion to see in the clinic how freely the blood spurts at the commencement of an operation, and how much less it will be toward the end, even when we cut larger vessels than were at first divided. Thus decrease of the total volume of blood may cause spontaneous arrest of haemorrhage ; the weaker contractions of the heart have also some influence in this. Indeed, in internal haemor- rhages that we cannot reach directly, we employ rapid abstraction of blood from the arm (venesection) as a haemostatic ; in such cases the artificial excitement of anaemia is not unfrequently the only remedy we have for internal haemorrhage, paradoxical as this may seem to SYMPTOMS— HEMORRHAGE. 23 you at the first glance. Haemorrhages from incised wounds of the large arteries of the trunk, neck, and extremities, are always so con- siderable that they absolutely require to be arrested, unless the open- ings in their walls be very small. But, when the terminal branch of an artery is ruptured without a wound of the skin, the haemorrhage may be arrested by pressure on the surrounding soft parts; such in- juries subsequently induce other changes, to which your attention will be called under other circumstances. Haemorrhage from the veins is characterized by the steady flow of dark blood. This is especially true of small and middle-sized veins. These haemorrhages are rarely very profuse, so that, in order to obtain a sufficient quantity on letting blood from the subcutaneous veins of the arm at the bend of the elbow, we must obstruct the flow of blood to the heart. If this were not done, blood would only flow from this vein, at the time of puncture, further haemorrhage would cease sponta- neously, unless kept up by muscular contractions. This is chiefly be- cause the thin walls of the veins collapse, instead of gaping, as the arteries do when divided. Blood does not readily flow back from the central end of the vein, on account of the valves ; we rarely have any thing to do with the valveless veins of the portal system. Haemorrhage from the large venous trunks is always a dangerous symptom. Bleeding from the axillary, femoral, subclavian or inter- nal jugular, is usually quickly fatal, unless aid arrive immediately ; wounds of the vena anonyma may be regarded as absolutely mortal. The blood does not flow continuously from these large veins, but the flow is greatly influenced by the respiration. In operations about the neck I have frequently seen patients live after their internal jug- ular vein had been wounded ; during inspiration the vessel collapsed so that it might have been regarded as a connective tissue string ; during expiration the black blood gushed up as from a well, or still more like the bubbling up of the water from a deep spring. In these veins near the heart, besides the rapid loss of blood, there is another element that greatly increases the danger ; this is the en- trance of air into the veins and heart, as occasionally takes place with a gurgling noise, on deep inspiration, when the blood rushes toward the heart ; this may cause instant death, though not necessarily. I cannot now enter more explicitly into this very remarkable phenom- enon, whose physiological effect has not, as it seems to me, been sat- isfactorily explained ; you will again have your attention called to this subject by the books and lectures on operative surgery. I shall merely mention that, on opening one of the large veins of the neck or the axillary vein, there may be a perceptible gurgling sound ; the patient instantly loses consciousness, and can rarely be restored to U SIMPLE INCISED WOUNDS OF THE SOFT PARTS. life by instantaneous resort to artificial respiration, etc. Death is probably caused by the entrance of air-bubbles, which press forward into the medium-sized pulmonary arteries, and are there arrested, and prevent further access of blood to the pulmonary vessels. I have never met any thing of the kind, although I have seen air enter the internal jugular vein, and frothy blood then escape ; this had no perceptible effect on the state of the patient. Different ani- mals appear to be susceptible, to various extents, to the entrance of air into the vessels ; if we throw only a little air into the jugular vein of a rabbit it dies ; while we may sometimes throw several syringe- fuls into dogs without observing any effects. Besides the above varieties of haemorrhage, we distinguish the so- called parenchymatous haemorrhage, which is sometimes incorrectly identified with capillary haemorrhage. In the normal tissue of an otherwise healthy body, parenchymatous haemorrhages do not come from the capillaries, but from a large number of small arteries and veins, which from some cause do not retract into the tissue and con- tract, and are not compressed by the tissue itself. Bleeding from the corpus cavernosum penis is an example of such parenchymatous haem- orrhages, which also occur from the female genitals and in the peri- neal and anal regions, as well as from the tongue and spongy bones. These parenchymatous haemorrhages are especially frequent from diseased tissue ; they also occur after injuries and operations, as so- called secondary hoemorrhages / but we shall speak of these here- after. One other point we must refer to here : this is, that there are per- sons who bleed so freely from a small, insignificant wound, that they may die of haemorrhage from a scratch of the skin, or after extraction of a tooth. This constitutional disease is called a hmmorrhagic dia- thesis ; people affected with it are called hawiophilen. The cause of this disease is probably abnormal thinness of the arterial walls ; this is congenital in most cases, but may probably result gradually from morbid degeneration and atrophy of the vascular tunics. This frightful malady is usually hereditary in certain families, especially among the males, the females being less liable to it. In these persons haemorrhage is caused not only by wounds, but light pressure may induce subcutaneous bleed- ing, spontaneous haemorrhages, as from the gastric or vesical mucous membrane, which may even prove fatal. It is not exactly in laige wounds where medical aid is called at once or very soon, but more particularly in slight wounds, that continued haemorrhages occur in such persons which are difficult to arrest, partly, as we above stated, on account of slight contractility or total lack of muscular tissue in the vessels, partly on deficient power of coagulation in the blood. It is SYMPTOMS— HEMORRHAGE. 25 true, the latter point has not been proved from the blood that escaped, for in the cases where attention was directed to this point the blood flowed like that of a healthy person. I shall also call your attention to some peculiarities in haemorrhages from certain localities, especially from those in the pharynx, posterior nares, and rectum, although, strictly speaking, this comes in the domain of special surgery. Wounds of the pharnyx or posterior nares, made through the open mouth by accident, are rare, but, as a result of con- stitutional disease, we may have very severe spontaneous haemorrhage from these parts, or these may result from operations, for we not un- frequently have to use knives and scissors here, or to tear out tumors with forceps. The blood does not always escape from the mouth and nose, but it may run down the pharynx into the oesophagus without being perceived. The general effects of rapid loss of blood come on rapidly, which we shall soon describe more minutely, but we ars unable to discover the source of the bleeding, which may be behind the soft palate. The patient soon vomits, and at once throws up large quantities of blood ; when this ceases there is another pause, and the patient, perhaps also the surgeon, thinks the haemorrhage has ceased, till more blood is vomited, and the patient grows still weaker. If the surgeon does not recognize these symptoms and apply proper remedies, the patient may bleed to death. I remember one case where several physicians gave various remedies for vomiting of blood and gastric haemorrhage after a little operation in the throat, and the source of the bleeding was finally recognized by an experienced old surgeon, who arrested it by local applications, and thus saved the life of the patient. The same thing may happen in haemorrhage from the rectum. From an internal wound the blood flows into the rectum, which is car pable of enormous distention ; the patient has a sudden desire to stool, and evacuates large quantities of blood. This may be repeated sev- eral times, till the rectum, irritated by the expansion, either contracts and thus arrests the haemorrhage, or till it is finally checked artificially. A rapid excessive loss of blood induces changes in the whole body, which are soon perceptible. The face, especially the lips, becomes pale, the latter bluish, the pulse is smaller, and at first less frequent. The bodily temperature sinks most perceptibly in the extremities ; the pa- tient, especially when sitting up, is subject to fainting-spells, dizziness, nausea, or even vomiting, his eyes are dazzled, and he has noises in the ears, every thing appears to whirl around; he collects his strength to hold himself up, he becomes unconscious, and finally falls over. These symptoms of syncope we refer to rapid anaemia of the brain. In a horizontal posture this soon passes off. Persons often fall into this 26 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. state from very slight loss of blood, occasionally more from loathing and aversion to the flowing blood than from weakness. A single fainting of this kind is no measure of the amount of blood lost ; the patient soon recovers his forces. Should the haemorrhage continue, the following symptoms appear sooner or later: the countenance grows paler and waxy, the lips pale blue, the eyes dull, the bodily temperature is lower, the pulse small, thready, and very frequent, respiration incomplete, the patient faints frequently, constantly grows more feeble and anxious ; at last he remains unconscious, and there is twitching of the arms and legs, which is renewed by the slightest irritation, as by the point of a needle, etc. ; this state may pass into death. Great dyspnoea, lack of oxygen, is one of the worst signs, but even here we should not hesitate ; we can often do something even after apparent death. Young women especially can bear enormous loss of blood without immediate danger to life ; you will hereafter have occasion to witness this in the obstetrical clinic. Children and old persons can least bear loss of blood ; in young children the results of the application of a leech are often evident for years by a very pallid look and increased excitability. In very old persons great loss of blood, if not immediately fatal, may induce obstinate collapse, which after days or weeks passes on to death ; this is probably because the loss of blood is immediately supplied by serum, and in old persons the formation of blood-corpuscles goes on slowly; the greatly-diluted blood proves insufficient to nourish the tissues, whose nutrition is at any rate very sluggish. When the patient comes to himself after severe haemorrhage, he has excessive thirst, as if the body were dried up, the vessels of the intestinal canal greedily take up the quantities of water drunk; in strong, healthy persons, the cellular constituents of the blood are quickly replaced, it is true we do not exactly know from what source ; after a few days, in a person otherwise healthy, we can perceive few signs of the previous anaemia ; soon, too, his strength has recovered from the exhaustion. LECTURE III. Treatment of Haemorrhage. — 1. Ligature and Mediate Ligature of Arteries.— Torsion. — 2. Compression by the Finger; Choice of the Point for Compression of the Larger Arteries. — Tourniquet. — Acupressure. — Bandaging. — Tampon. — 3. Styptics. — General Treatment of Sudden Anaemia.— Transfusion. Gentlemen : You now know the different varieties of haemorrhage. Now, what means have we for arresting a more or less severe bleeding ? TREATMENT OF HAEMORRHAGE— I JGATURE. 27 The number is great, although we use but few of them — only those that are the most certain. Here you have a field of surgical operation where quick and certain aid is required, so that the result must be unfailing. Still, the employment of these remedies requires practice ; cool-blooded quiet, absolute certainty, and presence of mind, are the first requisites in dangerous haemorrhage. In such circumstances a surgeon may show of what metal he is made. Haemostatics are divided into three chief classes : 1. Closure of the vessel by tying it — ligation. 2. Compression. 3. The remedies that cause rapid coagulation of blood, styptics (from otv 3 B - much to interstitial growth of the walls of the vessels. The original, formerly-existing vascu- lar union is thus replaced by a newly-formed vascular net-work which is at first far richer. Quite recently Arnold has most carefully studied the pro- cess of the development of ves- sels, and has seen it go on in the tails of tadpoles (Fig. 3 b.) Although the heart and larger vessels of the embryo seem to originate from appointed cell- groups of the middle germinal layer, by the peripheral parts forming the wall of the vessel and the central parts the blood- cells, later this does not seem to occur ; at least, observations made on this point by RoJcitansky and others do not seem to have ob- tained much credence. According to Arnold' 's investigations, off- shoots from the vessels seem to be the only mode of development of vessels in the embryo. I formerly thought that there must be another mode of growth for vessels in the formation of granulations and in some neo- plasia, namely, a tubular forma- tion by laying together spindle- cells, as at a, b, and c, in Fig. 3 c ; this I called " secondary " formation of vessels (" primary " I applied to the development of the heart and larger vessels in the middle germ-layer). The development of vessels by off- shoots I called " tertiary." But, since recent investigations, I The course of the formation of these vessels runs readily agree that the mode I a, b, e. These changes occurred in 10 hours. Magnified 300. After Arnold. termed " secondary " possibly did HEALING BY FIRST INTENTION. 67 not exist, and that the fine plasma string (the offshoot) and the fine tube, on which the spindle-cells growing out of the young adventitia lay, may have escaped my notice. But I will not neglect to mention that Thiersch^ supported by recent observations, has repeated his former assertions (which then seemed to me improbable) that in the young inflammatory neoplasia there is a net-work of tubes, connected with the blood-vessels by stigmata, which is bounded merely by the tissue- cells, not by special walls ; this agrees very well with the recent ob- servations on capillaries in inflamed tissues. According to this, there would be blood-vessels in this tissue which are not circular canals, but irregular intercellular passages, perhaps merely bounded by spin- dle-cells. Fig. 3 o. Disposition of vessels in the vitreous body of an embryo calf. Magnified about 600. After Arnold. As a result of the restoration of circulation through the young cica- trix, the circulatory disturbances caused by the injury are removed, the redness and swelling of the borders of the wound disappear ; from the numerous vessels, the cicatrix appears as a fine red stripe. Now 68 SIMPLE INCISED WOUNDS OF THE SOFT PARTS, the consolidation of the cicatrix must take place : this is accomplished, on the one hand, by the partial disappearance of the newly-formed vessels, whose walls fall tog-ether, and they thus become solid, fine, connective-tissue strings ; on the other hand, by the intercellular sub- stance becoming firmer and containing less water, as above mentioned, the cells assume the flat form of connective-tissue corpuscles, or disap- pear ; possibly some of them remain as wandering cells, and return again into the lymphatics or blood-vessels. To this condensation and atrophy is due the great contractile power of the cicatricial tissue, by means of which large, broad cicatrices may occasionally be reduced to half their original size. At the first glance, it might appear to you contradictory, that an apparently excessive capillary net-work should be formed in the young cicatrix, and should subsequently be for the most part obliterated. We cannot explain this apparent excess, still there are plenty of analogies in embryonal development ; I only need to remind you that there is a period in fcetal development when, even in the vitreous body, there is a capillary net-work, which, as you know, disappears, leaving scarcely a trace. Not to fatigue you with so-called theoretical subjects, I leave this field for a short time, and, before leaving healing by the first inten- tion, as a point fully understood, I shall make a few remarks on the causes that may prevent this mode of healing, even when the flaps of the wound are in apposition. Healing by first intention does not take place : 1. When the edges of the wound are brought together by plasters, or sutures, but their tension or tendency to separate again is very great. Under these circumstances, either the plasters do not keep the wound accurately closed, or the sutures cut through the flaps ; perhaps also the tension of the tissues obstructs the flow of blood in the capillaries, and thus disturbs the cell development and formation. How great this tension must be, and what means we have for relieving it, you can only learn in the clinic. 2. A further obstruction to healing is, a large amount of blood poured out between the edges of the wound ; this interferes with the process of healing, partly as a foreign body, and partly, if it decom- poses, by the influence of the process of decomposition. 3. Other foreign bodies, as sand, dirt, alkaline urine, faeces, etc., also retard the healing, partly mechanically, partly chemically. Hence these substances should be carefully removed before uniting the wound. In wounds of the urinary bladder, it is not usual to attempt the clos- ure of the skin- wound ; the urine would force its way into the sub- cutaneous cellular tissue, or into the peritoneal sac, and excite terrible HEALING BY FIRST INTENTION. 69 injury. Here, under some circumstances, it would be a decided fault to unite the wound, although of late the views on this particular point differ somewhat from those of former days. 4. Lastly, from a contusion, whose effect on the flaps of the wound we may fail to observe, there may have been an extensive disturbance of circulation and destruction of minute tissue, which has induced the partial death of certain parts or of the whole surface of the wound. Then, as there is no cell-formation in the edges of the wound, but only where the tissue is still living, we have small tags of the destroyed tissue lying as foreign bodies between the edges of the wound ; these must prevent healing by first intention. If this mortification attack only minute particles, these may possibly quickly undergo molecular disintegration and absorption ; this may occur not unfrequently. We shall speak more extensively of this mortification of the tissue, and of its detachment from the healthy parts, when treating of contusions. Experience, arising from many observations in judging of wounded surfaces, will hereafter enable you in most cases to say whether heal ing by first intention may be expected or not, and you will also learn when it may be useful, even in doubtful cases, to try to aid this union by applying dressings. You will occasionally hear of wonderful cases where parts of the body, completely separated, have again become united. This appears to be actually the case. I have never had the opportunity of making any observations on such cases ; still, even in late days, very trust- worthy men have asserted that they have seen small portions of skin again unite after being removed from the fingers by a blow or cut, then carefully replaced and fastened on with adhesive plaster. For- merly I contended against the possibility of this healing, but must now admit it, also on theoretical grounds, after it has become imaginable that, through the movements of the cells, the detached portions, if not too great, may soon be restored to life again by the entrance of wan- dering cells. That we may successfully transplant a twig, cut from one tree, into another one, is well known ; but, as the circulation in plants is not by pumping, but the sap runs simply by cellular force, the anal- ogy is not very close ; it was more remarkable, it is true, that a cock's spurs could be transplanted to his comb, but between birds and men the differences in the formative process are also very great, and any immediate transfer of observations is inadmissible in practice. When treating of the cicatrization of wounds with loss of sub- stance, we shall investigate the discovery of Heverdin that we may cause epidermis to grow on granulating surfaces.* 70 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. LECTURE VII. Changes perceptible to the Naked Eye in Wounds with Loss of Substance. — Finer Pro- cesses in Healing with Granulation and Suppuration. — Pus. — Cicatrization. — Ob- servations on "Inflammation." — Demonstration of Preparations illustrative of the Healing of Wounds. It now remains for us to inquire what becomes of the wound, if, under the above circumstances, it does not heal by first intention. Then, as the flaps gape, we have an open wound before us ; and the circumstances are the same as if the gaping wound had not been closed, or as if a piece had been cut out, as in a wound with loss of substance. Accurate observation of such wounds, which are usually covered with some unirritating body, as with a fold of linen dipped in oil, with oiled or dry eharpie, etc., shows the following changes — if we examine it daily, this is not necessary, it is true, and may even be in- jurious : after twenty-four hours, you find the borders of the wound slightly reddened, somewhat swollen, and sensitive to the touch ; the same symptoms as in closed wounds. As in healing by first inten- tion, these symptoms may be very insignificant or entirely absent, as in old, relaxed, flabby skin, also in strong skin with thick epidermis. We observe these symptoms best in the skin of healthy children. An extensive and increasing redness, swelling, and pain about the wound, make us suspect an abnormal course ; just as, with the same symptoms in a wound healing by first intention, various individual circumstances are to be considered, and the vibrations from the normal to the abnor- mal are so numerous, that the dividing line is often difficult to deter- mine. After the first twenty-four hours, the surface of the wound has changed but little ; all over it you can still recognize the tissues quite distinctly, although they have a peculiar gelatinous, grayish appear- ance ; you also find a considerable number of yellowish or grayish-red small particles over the surface ; on close examination, you find these to be small fragments of dead tissue, which still adhere, however. The second day, you may already notice a trace of reddish-yellow, thin fluid over the wound, the tissues appear more regularly grayish red and gelatinous, and their boundaries become more indistinct. The third day, the secretion from the wound is pure yellow, somewhat thicker, most of the yellow dead particles are detached and flow off with the secretion ; the surface of the wound becomes more even and regularly red — it cleans off", as we say technically. If you had not bound up the wound (a stump from amputation, for instance), and had received in a basin the secretion that formed, the first and second day you would find it bloody, brownish red, then of a gelatinous dirty gray, HEALING BY GRANULATIONS. 7! then dirty yellow : at the points where the secretion flows from the wound, fibrine not unfrequently stiffens in drops. If you examine care- fully with a lens, even the third day, you will see numerous red nod ules, scarcely as large as a millet-seed, projecting from the tissue — small granules, granulations, fleshy warts. By the fourth or sixth day these have greatly developed, and gradually join into a fine, granu- lar, bright-red surface — the granulating surface / at the same time, the fluid flowing from this surface becomes thicker, pure yellow, and of creamy consistence ; this fluid is pus, and, when of the quality here described, it is good pus, pus bonum et laudabile of old authors. Of this normal course there are many varieties, which chiefly de- pend on the parts injured, and the mode of injury ; if large shreds of tissue from the surface of the wound die, the wound is longer in clean- ing off, and then you may sometimes see the white, adherent shreds of dead tissues still clinging for days to the surface, most of which is al- ready granulating. Tendons and fasciae are particularly apt to have their circulation so impaired, even by simple incised wounds, that they die to an unexpected extent from the cut surface, while there is little loss of loose cellular tissue or muscle. This is undoubtedly due partly to deficient vascularity of the tendinous parts, partly to their firm- ness, which does not permit rapid collateral dilatation of the vessels ; the same is true in injuries of bone, especially of the cortical substance, where there is often death of the injured bone-surface, that requires a long time for detachment. Other obstacles to active development of granulations are constitutional conditions; for instance, in very old or debilitated persons, or badly-nourished children, the develop- ment of granulations will not only be very slow, but they will look very pale and flabby. Hereafter, at the close of this chapter, I will give you a short review of those anomalies of granulation which are daily occurrences in large wounds, and, to a certain extent, may be regarded as normal or at least customary. But, to return to the observation of the normally- developing layer of granulations, with the continued secretion of pus, you perceive that the granulations become more and more elevated, and sooner or later attain the level of the skin, and not unfrequently rise above it. With this process of growth, the individual granules become thicker, and more confluent, so that they can hardly be recognized as separate nodules ; but the entire surface assumes a glassy, gelatinous appearance. Occasionally the granulations remain for a long time at this stage, so that we have to use various remedies to restrain the proliferating neoplasm within bounds that are requisite for recovery; on the periphery, particularly, the granulations should not rise above the level of the skin, for the cicatrization has to commence at this point. 72 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. The following metamorphoses now gradually occur : t-he entire surface contracts more and more, becomes smaller ; on the border, between skin and granulations, the secretion of pus diminishes ; first, a dry, red border, about half a line broad, forms and advances toward the centre of the wound, and, as it progresses and traverses the granular surface, it is followed closely by a bluish-white border, which passes into nor- mal epidermis. These two seams result from the development of epidermis, which advances from the periphery toward the centre ; cicatrization begins ; the young cicatricial border advances half a line or a line daily ; finally, it covers the entire granulation surface. The young cicatrix then looks quite red, and is thus sharply defined from the healthy skin ; it feels firm, more so than the cutis, and is still very intimately connected with the subjacent parts. In the course of some months, it gradually grows paler, softer, more movable, and finally white ; in the course of months and years, it grows still smaller, but often remains whiter than the cutis all through life. The strong contraction in the cicatrix often causes traction on the neigh- boring parts, an effect that is occasionally desirable, but sometimes very unwelcome, as, for instance, when such a cicatrix on the cheek draws the lower eyelid down, causing ectropion. You will occasionally see it asserted that the cicatrization of a granulating surface may sometimes begin from several patches of epidermis forming in its midst. This is only true of cases where por- tions of cutis with rete Malpighii have remained in the midst of the wound, as may readily happen in gangrenous wounds, as the caustic agent may penetrate unequally deep. Under such circumstances, epi- dermis again forms from some remaining portion of the papillary layer, that has the slightest possible covering of cells of the rete Mal- pighii ; at these points we have the same circumstances as when we have raised a vesicle on the skin by cantharides, inducing by the rapid exudation an elevation of the epidermis from the mucous layer of the skin ; this is followed by no granulations, if you do not continue to irritate the surface, but horny epidermis again forms at once over the mucous layer. But, if there be no such remnant of rete Malpighii, we never have these islands in the cicatrix, the formation of epidermis only takes place gradually, from the periphery of the wound toward the centre. I believe this so firmly, that I think surgeons, who say they have seen otherwise, must be mistaken in some way. The transplantation of epidermis after Reverdirts method also ap- pears to me to favor the view that epithelium is only developed from epithelium. After having considered the external conditions of the wound, the development of granulations, of pus, and of the cicatrix, we must DILATATION OF THE VESSELS. 73 now turn again to the more minute changes by which these external symptoms are induced. It will be simplest for us, again, to represent a relatively simple capillary net-work in the connective tissue : suppose a crescentic piece to be cut out of it from above ; first, there will be bleeding from the ves- sels, which will be arrested by the formation of clots as far as the next branches. Then, there must be dilatation of the vessels about the wound, which is due partly to fluxion, partly to increased press- ure; an increased transudation of blood serum, or an exudation, is also a necessary result of the capillary dilatation, from causes above given; the transuded serum contains some fibrogenous substance, which, by the influence of the newly-formed cells in the most super- ficial layers, coagulates to fibrine, while the serum, mixed with blood plasma, flows off. The vascular net-work would assume the following shape : - Fig. 4. Diagram of a wound, with loss of substance. Vascular dilatation, magnified 300-400 times. In most cases, from insufficient supply of blood-plasm at the sur- face of the wound, more or less particles of tissue will die ; as the stoppage of vessels must, of course, deeply affect the nutrition of tis- sues not very vascular, and, where the tissues are very stiff, dilatation 74 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. of the vessels will be interfered with. Let us suppose that the upper layer, shaded in the diagram, is dead from the changes in the circula- tion. What will now take place in the tissue itself? Essentially, the same changes as in the united edges of a wound ; wandering of white-blood cells through the walls of the vessels, their collection in the tissue with the secondary action they induce ; plastic infiltra- tion, and inflammatory new formation. But, since there is no oppos- ing wounded surface, with which the new tissue can coalesce, then to be quickly transformed to connective tissue, the cells, escaping from the vessels, remain at first on the surface of the wound ; the exuded fibrinous material on the surface of the wound becomes soft and gelatinous ; at the same time, the infiltrated tissue of the surface of the wound assumes the same peculiarities ; the soft connective tissue, into which the young vessels shortly grow, even if only present in small quantities, holds together the cells of the inflammatory new for- mation, which constantly increase in number. The granulation tissue is thus formed ; this is, therefore, a highly-vascular inflammatory new formation. At first, it grows constantly, the direction of its growth is from the bottom of the wound toward the surface ; the tissue is, however, of different consistence in the various layers, its superficial surface especially is soft, and most superficially of fluid consistence, for here the intercellular substance becomes not only gelatinous, but fluid ; this uppermost thin fluid layer, which is constantly flowing and being constantly renewed from the granulation tissue by cell-exu- dation, is^s (Fig. 6). Hence, pus is fluid, as it were melted, dissolved inflammatory new formation. Where pus is present in quantity it must have come from some sort of granulation tissue or from some other highly-vascular and usually highly-cellular source ; this source need not always be a surface, as in the present case, but may lie deep in the tissue and form a cavity ; the centre of an inflammatory new formation anywhere in the tissue may break down into pus ; then we have an abscess. We shall frequently have occasion to speak of this relation of pus and granulations to each other ; hold fast to the idea of granulations being tissue (not granules), and of pus being fluid inflammatory new formation, and you will hereafter readily understand many processes, especially chronic inflammations, whose variable appearance you would otherwise find incomprehensible. Let us now say a few words about pus itself. If left standing in a vessel, it separates into an upper, thin, clear layer, and a lower yel- low one ; the former is fluid intercellular substance, the latter contains chiefly pus-corpuscles. On simple microscopic examination these are round, finely punctated globules, of the size of white-blood corpuscles ; GRANULATION TISSUE. 75 they contain three or four dark nuclei, which become quite distinct on addition of acetic acid, because it dissolves the pale granules of the protoplasm, or at least swells them so that they become transpar- ent. The nuclei are not soluble in acetic acid ; the entire globule ia readily dissolved in alkalies. a, Fig. 5. Pus-cells from fresh pus, magnified 400 times, a, dead without addition ; b, the same cells after addition of acetic acid; c, various forms that living pus-cells assume in their amoeboid movements. At a and b we see the pus-cells as they usually appear when we cover a drop of pus with a thin glass, and without any addition ex- amine it under the microscope. The above-mentioned observations of Von Recklinghausen have shown that only the dead cells have this round shape ; if we observe the pus-cells in the moist chamber on a warmed object-table (according to M. Schultze), we see the amoeboid movement of these cells most beautifully. These movements, which only go on slowly and sluggishly at blood-heat, become more rapid at a higher temperature, and less so at a lower. The number of pus- cells in pus is so great, that in a drop of pure pus, under the micro- scope, the fluid intercellular substance is not at all perceived. Chemi- cal examination of pus is difficult, first, because the corpuscles can- not be completely separated from the fluid; also, because the large quantities of pus obtainable for chemical examination had already been a long time in the body, and may have changed morphologically and chemically ; and lastly, because chiefly protein substances are con- tained in pus, whose perfect separation hitherto has not always been possible. If we let pus from a wound stand in a glass, the clear, bright-yellow serum usually occupies more space than the thick, straw- yellow sediment, which contains the pus-corpuscles. Pus contains ten to sixteen parts of firm constituents, chiefly chloride of sodium ; the ashy constituents are about the same as those of blood-serum. Recent examinations of pus have shown that myosin, paraglobulin, protagon, fatty acids, leucin, and tyrosin, are constant constituents. Pus collected in the body does not readily undergo acid fermenta- tion ; pure fresh alkaline pus soon becomes sour, however, if it is left standing for a time even in a covered glass. Let us now return to the granulation layer, where we have still an important point to consider, namely, the numerous vessels, which 76 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. give its red appearance. The extensive vascular loops that must form on the surface of the wound, and which in the diagram (Fig. 6) are too small and too few, commence, with the growth of the surround- ing granulation tissue, to elongate and become more tortuous ; tow- ard the .fourth or fifth day new vessels develop as fine lateral capil- lary communication, as in healing by first intention, and the tissue is soon traversed by an excessive number of vessels, which have so much effect on the appearance of the entire granulation surface that it is hardly recognizable on the cadaver, where the fulness of the ves- sels is wanting, or is at least less marked than during life, and the tissue consequently appears pale, relaxed, and much less thick. The question arises, Whence come these remarkable, small, gradually-con- fluent red nodules, which are visible to the naked eye ? Why does not the surface look even ? Indeed, this is frequently the case ; the granules are by no means always distinctly defined ; but it is not easy to explain the cause of their form. It is usually assumed that the granules are to be regarded as imitations of the cutaneous papillae; but, independent of the fact that it is incomprehensible why such structures should be imitated in muscle and bone, and that the gran- ules are usually ten times as large as the cutaneous papillae, this is no real explanation. The appearance of the granules, doubtless, de- pends on the arrangement of the vascular loops into tufts, on certain boundaries between the different groups of vessels. Hence we might suppose that the vascular loops acquire this form without known cause. Still, it seems to me natural to compare them to the circum- scribed capillary districts, already formed in the normal tissues, of which we have numerous examples, especially in the skin and in fat. You know that every sweat and sebaceous gland, every hair-follicle and fat-lobule, has its nearly-closed capillary net-work, and, by the enlargement of such capillary net-works, the peculiar closed vascular forms of the granules might arise. In fact, in the cutaneous and fatty tissue you will find the individual fleshy growths, particularly sharply and clearly defined, while this is more rarely the case in muscle, where these bounded capillary districts do not occur. It can only be decided by artificial injections of fresh granulations, whether this explanation is correct ; till then, it remains simply an attempt to refer this pathological new formation to normal anatomical con- ditions. The following sketch, in which, on account of the great enlarge- ment, and the small injured district, nothing can be seen of the granu- lar layer, may serve you as a diagram of the development of the gran- ulation tissue with its vessels, and of its relation to pus and to the subjacent matrix, as it has developed from Fig. 4. RESULTS OF GRANULATION. 11 If the growth of the granulations was not arrested at some point, a constantly-growing granulation tumor would be formed. Fortu- nately, this is never or very rarely the case. You already know, from the representation of the external conditions, that when the granula- tions have reached the level of the cutis, or even sooner, they cease to grow and are coated with epidermis, and retrograde to a cicatrix. The following changes occur in the tissue : At first, in the granula- tion tissue, as in the edges of the wound in healing by the first inten- tion, there are numerous cells which are destroyed. Not only the millions of pus-cells on the surface, but also cells in the depths of the granulation tissue, disappear by disintegration and reabsorption ; it is very probable that cells from the granulation tissue may pass back un- injured into the vessels, as we shall see when treating of the organi- zation of thromboses of the vessels. As the cells retrograde, fine fat- granules'gradually form in them, not only in the round but also in the spindle-shaped ones ; such cells, which are composed of very fine Pig. 6. Diagram of granulation of a wound ; the layer of pus-cells is represented as having been acted on by acetic acid, to distinguish the pus-cells in the figure more accurately from the granu- lation cells. Magnified 300-400 diameters. 18 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. fat-globules, are generally called granular cells (Kdrnchenzellen) ; they often occur in the granulations, as above described. When the gran- ulation tissue is thus diminished by atrophy and escape of the cells, and at the same time the new formation of cells ceases, something im- FlG. Patty degeneration of cells from granulations. Granulation-cells. Magnified about 500 diameters. portant must happen, that is, the gradual consolidation of the gelat- inous intercellular tissue to striated connective tissue, which is brought about by the steadily increasing loss of water, that is carried off by the vessels and evaporated from the surface ; then the remain- ing cells at once assume the shape of the ordinary connective-tissue Fig. 7 a. a, Epithelial cells from frog's cornea, throwing out shoots at the edge of a loss of substance, b, Some cells detached from such a border. Magnified about 660. Heiberg. corpuscles. According to the view of other observers, the original intercellular substance entirely disappears, and its place is supplied by the protoplasm of granulation cells, which transforms into fibrous tis- sue. With these changes which take place from the periphery tow- ard the centre, the secretion of pus on the surface ceases ; at the very RESULTS OF GRANULATION. 79 circumference of the wound on the condensing granulation tissue epidermis forms and quickly separates into hard epidermic and mucous layers ; according to J, Arnold, this formation takes place by the di- vision of a protoplasm, at first entirely amorphous, in the immediate vicinity of the existing border of epidermis. Lastly, the superfluous capillaries must be obliterated; few of them remain to keep up the circulation through the cicatrix. With their obliteration the tissue be- comes drier, tougher, contracts more and more, and often the cicatrix does not acquire its permanent form and consistence for years. The whole process, like all these modes of healing, contains much that is very remarkable, although recent investigations have explained many of the more minute morphological changes. The possibility, nay, the necessity, under otherwise normal circumstances, of arriving at a typical termination, is the chief characteristic of those new forma- tions that are induced by an inflammatory process. If this natural course of healing does not take place, it is because either constitu- tional or local conditions indirectly or directly interfere, or because the organ attacked is so important to life, the disturbance to the entire body so severe, that there is death of the organ, or of the individual, or that the functional disturbance of the former causes the death of the latter. Every new formation, due to inflammation, always has the tendency to reach a certain point, to retrograde, and pass into a sta- tionary state, while other new formations have no such natural termi- nation, but usually continue to grow. Different as healing by the first and second intentions appears, at the first glance, the morphological changes in the tissue are in both cases the same ; you only need to divide Fig. 3 at a, to have the same picture as in Fig, 6. Observation teaches in the simplest manner that this is actually so ; if a wound almost healed by first intention, but not yet consolidated, be torn open, we have a granulating wound which soon suppurates. You will hereafter be frequently convinced of this in practice. The above process of healing by immediate adhesion and by gran- ulation we have termed traumatic inflammation, and have found it identical with some other forms of inflammation ; it has also been stated that a marked peculiarity of traumatic inflammation is, that in it, without some further cause, the irritation in the tissue does not extend beyond the immediate vicinity of the injury. I beg you carefully to remember this limitation. As we know nothing ac- curately about the chemical changes and nerve-actions in the in- flamed tissue, while we do know the morphological processes very accurately, we naturally attend most to the latter if we wish to de- fine and generalize the term " inflammation." I will briefly take up 80 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. the previous views on this subject (p. 48). " Inflammation " is a modification of the normal physiological processes in the different tissues of the body, a " disturbance of nutrition " ( Virchow) whose histopoetic results you now know and of whose destructive, deleteri- ous actions you will hereafter hear. Any part of the body was said to be " inflamed " when it was hot and red ; as it is then generally swollen and painful also, this name is applied to processes where the above symptoms occur. The word inflammation originated when there were no true pathologico-anatomical ideas ; even the oldest ob- servers understood that something unusual was going on in the tissues, that they were much heated {inflammatio) , and from the first this process has been regarded as an intense increase of the vital processes. As they could not understand the process itself any bet- ter than we do, they considered the symptoms and the results of the process, just as we do ; so that doubts often arose if it were proper to speak of inflammation when one or other symptom was absent or not well marked, just as it is to-day. We now know that inflammation is not an existence outside of the body, which makes its way into some part and there grows, and must be expelled like Beelzebub, and we know why " tumor, rubor, calor, dolor," are caused by in- flammation, but although any one usually recognizes an acute inflam- mation as such and designates it correctly, it still remains difficult as well clinically as anatomico-pathologically to give an exact definition of " inflammation." There is no difficulty in distinguishing an oak from an ass ; but, if you attempt to generalize and give a sharp defi- nition between plants and animals, you will have the greater difficulty the more you know of the details of botany and zoology. The word "inflammation" is in use, and so accurately designates those pro- cesses to which it was first applied, that it would be useless to try to root it out. By it we understand the above-described combination of processes in the tissues, which in the present case arise from a purely mechanical irritation (wound) acting only once. How much hyperemia, exudation, and new formation of tissue is required before we can term the process inflammation cannot be stated absolutely. It seems to be agreed by surgeons and anatomists to designate as " inflammatory " the purely regenerative processes, that is, the neo- plastic tissues, which directly or indirectly replace the loss of sub- stance. If we consider the process in the modern histological sense, it cannot be accurately defined from the inflammatory, slight as it may be occasionally. From a purely clinical point of view, the distinction is easier, as we often meet cases without any of the four cardinal symptoms on the edges of the wound ; and still the difference be- tween a slight redness, swelling, and sensitiveness of the borders of PREPARATIONS SHOWING HEALING OF WOUNDS. 81 the wound to an intense, progressing inflammation over the entire affected portion of the body is only one of degree. Custom has here made a distinction ; when a wound heals without any symptoms of so-called reaction we do not call it inflammation of the wound, but only apply this term when the symptoms of inflammation are very prominent at the part injured. I deemed it necessary to speak to you of these general consider- ations on inflammation, so that you might early learn some of the difficulties of the subject. In these lectures it will always be my ob- ject to explain to you, as clearly as is now possible, the anatomico- pbysiological disturbances, and at the same time to show you histo- logically the origin of the clinical descriptions and expressions now in use. This is the only way we can truly ground our knowledge ; without understanding this you would always be feeling around the outside of symptoms, and by clinging to certain ones fall into in- curable dogmatism, which in a country doctor the world calls " nar- row-mindedness," in the eminent city physician " infallibility." As the great majority of men are stupid in physical matters, you are sure even with the latter peculiarities of attaining great practical success, but you must then renounce all idea of appreciating or ad- vancing the progress and development of society. It is not the object of these lectures to show you on preparations, step by step, the morphological microscopical changes in wounded tissue — you will see these, in the practical lessons on pathological histology — but I will show you a few points, so that you may not think that the pro- cesses of which I have spoken can only be demonstrated on diagrams. The cell-infiltration of tissue, after irritation by an incision, is best seen in the cornea. Four days ago I made an incision, with a lance- shaped knife, in the cornea of a rabbit ; yesterday the incision was visible as a fine line with milky cloudiness. I killed the animal care- fully, cut out the cornea, and let it swell in pyroligneous acid, till this morning ; then made a section through the wound, and cleared ifc up with glycerine. Now, at a a (Fig. 8), you may see the connecting substances be- tween the edges of the wound, in which there has been a considerable collection of cells, between the lamellae of the cornea, where the cor- neal corpuscles lie. These cells are not so evident in the method em- ployed as in that where carmine is used, still the intermediate sub- stance between the edges of the wound is very distinct. As you see, it consists almost entirely of cells ; the cells alone would not, however, render the union sufficiently firm, if they were not glued together by a fibrinous cement. The young cells probably come out of the edges of the wound from the fissures between the corneal lamellas, and prob- ably do not originate in the connective substance between the edges 6 82 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. of the wound ; on the contrary, the latter is finally formed from them. Let me remark incidentally, these fine corneal cicatrices subsequent- ly clear up, so as to leave scarcely a trace. All the cells that you here see in the preparation come from the vascular loops of the con- junctiva ; the normal stellate corneal cells are not visible here. I have chosen this specimen because the intermediate substance is broad and very rich in cells. In very small incisions, made in the cornea with a very sharp knife, the intermediate substance is so slight, that it is seen with difficulty ; then, too, the changes on the edges of the wound are slighter than here, and so slight a scar is not visible to the naked eye. Here (Fig. 9) you have a transverse section through a twenty-four- Fig. 8. Corneal incision three days old ; a a, the uniting substance between the two ion. Magnified 300 diameters. of the incis- liour old, freshly-united wound in the cheek of a dog. The incision is well marked zX a a ; the edges of the wound are separated by a dark, intermediate substance, which consists partly of white cells, partly of red corpuscles — the latter belong to the blood, escaped between the edges of the wound, after the injury ; the connective-tissue fissures crossed by the wound, in which the connective-tissue cells lie, are already filled with numerous newly-formed cells, and these cells have already pushed into the extra vasated blood between the edges of the wound. The preparation has been treated w T ith acetic acid, hence you no longer see the striation of the connective tissue, but see the young cells more distinctly. Look particularly at certain strings, rich in cells, that extend from the wound toward both sides (b b b) ; these are blood-vessels in whose sheaths many cells are infiltrated ; this is apparently because here many w T hite-blood cells have passed through PREPARATIONS SHOWING HEALING OF WOUNDS. 83 Incised wound twenty-four hours old, in the cheek of a dog. Magnified 300 diameters. the walls of the blood-vessels, or are about to do so. About the transformation of the coagulated blood between the edges of the wound, the wound thrombus, we shall hereafter speak more fully when treating of cicatrices of the vessels at the end of this chapter. This preparation (Fig. 10) shows a young cicatrix, nine days after the injury. Fie. 10, Cicatrix nine days after an incision through the lip of a rabbit, healed by first intention. Magni fied 300 diameters. The connective substance (a a) between the edges of the wound consists entirely of spindle-cells pressed together, which are most inti- mately connected with the tissue on both sides of the wound. 84 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. Fine sections cannot be made of granulation tissue, just taken from a wound ; it is generally a very difficult subject for fine prepara- tions. If you harden the granulation tissue in alcohol, color the sec- t ion with carmine, then clear it up with glycerine, you have a speci- men like Fig. 11. Fig. 11. Granulation tissue. Magnified 300 diameters. The tissue appears to consist solely of cells and vessels, with very thin walls ; the whole tissue is shrunken by the alcohol, so that we here see nothing of the mucous intercellular substance which is al- ways present, even if only in small quantities, in healthy, fresh granu- lations. We see the tissue of the young cicatrix particularly well in the following preparation (Fig. 12), which was taken from a broad cica* trix, following granulation and suppuration, in the back of a dog, about four or five weeks after the injury. Fie. 12. Young cicatricial tissue. Magnified 300 diameter*. PREPARATIONS SHOWING HEALING OF WOUNDS. 85 The preparation has been treated with acetic acid, to show the ar- rangement of the connective-tissue cells, that have formed from the granulation tissue ; a a a are partly obliterated, partly still permeable blood-vessels ; the connective-tissue cells are still relatively large, suc- culent, and distinctly spindle-shaped, still the intercellular substance is richly developed. To study the state of the blood-vessels in the wound, we must make injections ; this is quite difficult, and quick success often depends on a lucky chance. Fig. 13. Horizontal section through the tongue of a dog-, near the surface, marie with a hroad knife. Frontal section through the tongue after injection and hardening, forty-eight hours after the injury. Magnified 70-80 diameters ; after Wywodzqf—a a, intermediate substance between the edges of the wound (consisting of filamentary-looking adhesive material and estrava- sated blood). The section has passed through two layers of muscle crossing each other. Looping of the vessels with dilatation in both borders of the wound ; commencing elonga- tion of the loops into the connective suhstance. On this subject we have the recent works of Wywodzoff and Thiersch, whose results in the main agree partly with one another, partly with my investigations on this subject. Wywodzoff, who op- orated on dogs' tongues, gives a series of representations of the con- 86 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. dition of the blood-vessels in various stages of healing of the wound, a few of which I shall demonstrate to you, without, however, going into the more minute details of the formation of vessels. Fig. I Similar section of a dog's tongue as in Fig. 13. — Cicatrix (a) ten days old: everywhere anas- to -noses of the vessels from the two edges of the wound. Magnified 70-80 diameter; niter Wyuxctnff. Fig. 15. Similar section of a doe's tonsrae as in Fisr. 13.— Cicatrix (a) sixteen davs old. The vessels already greatly diminished and ai rophied. Magnified 'TVS ) diameters : alter Wywodzoff. PREPARATIONS SHOWING HEALING OF WOUNDS. 87 This (Fig. 16) is a preparation of granulations from a human be- ing, where the vessels were tolerably filled by natural injection ; tLe vascular loops are very close together and complicated at the surface; leep down the vessels run nearly parallel. Fia. 16. Granulation vessels. Magnified 40 diameters. In conclusion, here is a preparation of injection of the lymphatic vessels of a dog's lip. You see that the young cicatrix, on the seventh day, when it still consists almost exclusively of cells, has no lymphatin Fig. 17. Seven-days-old wound in the lip of a dog. Healing by the first intention. Injection of the lymphatic vessels : a, mucous membrane ; b, young cicatrix. Magnified 20 diameters. vessels ; these cease immediately at the young cicatrix ; they do not form in the cicatrix till the fibrillar connective-tissue bundles form. The granulation tissue also has no lymphatic vessels; where the in- 88 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. flammatory new formation, where the primary cellular tissue forms, the lymph-vessels are mostly closed, partly by fibrous coagulations, partly by new cell formations. These observations have also been confirmed quite recently by Zosc7i, of St. Petersburg, by examinations of trau- matically inflamed testicles. LECTURE VIII. General Eeaction after Injury. — Surgical Fever. — Theories of the Fever. — Prognosis.— Treatment of Simple Wounds and of Wounded Persons. — Open Treatment of Wounds. Gentlemen : You now know the external and internal minute processes in the healing of wounds, so far as it is possible to follow them with our present microscopes. Of the wounded person we have not yet spoken. If you have crit- ically examined his condition, you will have noticed changes, which may not be explained by cell-knowledge (mit Zellenweisheit), and perhaps not at all. ■ Possibly even the first day the patient may have been restless toward evening ; he may have felt hot, thirsty, with no appetite, some headache, wakeful at night, and dull the next morning. These sub- jective symptoms increase till the evening after the next day. If we feel the pulse, we find it more frequent than normal, the radial artery is tenser and fuller than before ; the skin is hot and dry ; we find the bodily tempertaure elevated ; the tongue is coated and readily becomes dry. You already know what ails the patient — he has fever. Yes, he has fever ; but what is fever ? whence comes it ? what connection is therebetween the different remarkable subjective and objective symp- toms ? But do not ask any more questions, for I can scarcely answer those already proposed. By the name " fever " we designate the combination of symptoms which, in a thousand different shapes, almost always accompanies in- flammatory diseases, and is generally apparently due to them. We know its duration and course in various diseases ; still, its nature is not fully understood, although it is better known than formerly. The different fever symptoms appear with very variable intensity. Two of these symptoms are the most constant, viz., the increase of pulse and bodily temperature ; we can measure both of them, the first by counting, the latter by the thermometer. The frequency of the heart's beat depends on many things, especially on psychical excite- ment of all sorts ; it shows slight differences in sitting, lying, standing, SURGICAL FEVER. 89 walking. Hence, there are many things to which we must attend, if we would avoid error. However, w^e may avoid these mistakes, and for centuries the frequency of the pulse has been used as a measure of fever. Examination of the pulse also shows other things important to be known : the amount of the blood, tension of the arteries, irregu- larity of the heart-beat, etc. ; and it should not be neglected even now that we have other modes of measurement of the fever. This other, and in some respects certainly better, mode of measuring the amount and duration of the fever is determination of the bodily temperature with carefully-prepared thermometers, whose scales are divided, accord- ing to Celsius, in one hundred degrees, and each degree in ten parts. The introduction of this mode of measurement into practice is due to Von Btirensprung, Traube, and Wunderlich ; it has the advantage of graphically presenting the measurements, which are usually made at 9 A. m. and 5 p. m., as curves, and making them at once easily read. A series of observations of fever in the normal course of wounds shows the following points: traumatic fever occasionally begins imme- diately after an injury, more frequently not till the second, third, or fourth day. The highest temperature attained, although rarely, is 104.5° F.-105.5 ; as a rule it does not rise much above 102°-103°. Simple traumatic fever does not usually last over a week ; in most cases it only continues from two to five days ; in many cases it is en- tirely absent, as in most of the small superficial incised wounds of which we spoke above. Traumatic fever depends entirely on the state of the wound ; it is generally of a remitting type ; the decline may take place rapidly or slowly. From these observations we should naturally suppose the fever would be the higher the more severe the injury. If the injury be too insignificant, there is either no fever or the increase of temperature is so slight and evanescent as to escape our modes of measurement. It has been thought that a scale of injuries might be constructed, according to which the fever would last a longer or shorter time, and be more or less intense, in proportion to the length and breadth of the wound. This conclusion is only approximately correct, after making very considerable limitations. Some persons become feverish after very slight injuries ; others do not, even after severe ones. The cause of this difference in the occurrence of traumatic fever depends partly on whether the wound heals with more or less inflammatory symptoms, partly on unknown influences. We cannot avoid the supposition that purely individual circumstances have some influence : we see that, from similar injuries, one person will be more disposed to fever than an- other. Before going on to examine how the state of the wound is related 90 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. Co the general condition, we must examine the latter a little more carefully. The most prominent and physiologically the most remark- able symptom of the fever is the elevation of the temperature of the blood, and the consequent increase of the bodily temperature. All the modern theories of fever turn on the explanation of this symptom. There is no ground for supposing that in fever any absolutely new element must be added to the requirements acting for the preservation of a constant temperature in the body, but it is probable that the fever temperature is caused by some change of the normal requirements of temperature, which vary readily with circumstances. When you re- member that men and animals in the varied temperatures of summer and winter, in hot and cold climates, have about the same temperature of the blood, you will see that the conditions of production and giving off of heat are susceptible of great modification, and that within these conditions there may very possibly be abnormities of the resulting bodily temperature. It is evident a priori that an increase of bodily temperature may depend either on diminution of the amount of heat given off, the production remaining the same, or on increased produc- tion, the loss of heat remaining the same (other relations of these factors to each other are possible, but I shall pass over them, to avoid confusing you on this difficult question). The decision of this cardinal question does not seem possible at present ; it would be possible by determining and comparing the quantity of heat produced in fever and in normal conditions, by the so-called calorimetrical experiments on men and large warm-blooded animals ; but hitherto there have been great difficulties in the way of these experiments. Liebermeister and Ley den have invented methods of calorimetry, that seem to me cor- rect; but the methods and conclusions of Liebermeister have been energetically combated by Senator. Hence, in regard to the above questions, we are still, to a great extent, thrown on probability and hypothesis. As the production of heat depends chiefly on oxidation of the constituents of the body, increase of the latter would necessarily be followed by increase of the former if the loss of heat remained the same. Now, since the amount of urea is regarded chiefly as the result of the burning up of the nitrogenous bodies, and as the amount of urea excreted in fever is usually increased, and the weight of the body rapidly decreases, as appears from the experiments of 0. Weber, Lieber- meister, Schneider, and Ley den, this, with the above-mentioned calori- metric experiments, is considered strong proof that in fever the con- sumption is greatly increased, and that consequently more warmth is really produced than in the normal state, more than can be disposed of by the body in the same time. Traube gives another view of the occurrence of fever-heat : he asserts that every fever begins with ener- ELEVATION OF TEMPER ATUKE IN INFLAMMATION. 91 getic contraction of the cutaneous vessels, especially of the smallei arteries, and that thus the giving off of heat to the air is decreased, and more heat collected in the body, without its actually producing more. Although this hypothesis is advanced by its author with wonderful ability and acuteness, and is apparently supported by the work of Senator, I, with most pathologists, cannot agree with it, especially as the premises, the contraction of the cutaneous vessels, can only be ac- knowledged in the cases begining with chill ; but this chill is by no means a constant symptom in the fever. Hence, in what follows, we shall start from the point that in fever there is increased production of heat. Then arises the question, How does inflammation generally, and traumatic inflammation particularly, effect the increase of bodily temperature ? This question is answered in various ways : 1. At the point of inflammation, as a result of the lively interchange of tissue, heat is produced ; the blood flowing through the inflamed part is warmed more, and distributes the abnormal amount of heat here acquired, to the whole body. That the inflamed part is warmer than the non-inflamed is readily proved, especially in superficial parts, as in the skin, but this does not prove that more warmth is produced here than is usual, but is probably simply due to the circulation of more blood through the dilated capillaries ; if the inflamed part be not warmer than the blood flowing to it, it is not probable that it should produce heat. The investigations on this point are numerous and contradictory. The thermometrical measurements of 0. Weber and Hvfschmidt have given various results ; usually the temperature in the wound and in the rec- tum (which has about the warmth of arterial blood) were equal; occa- sionally the former was higher than the latter, sometimes the reverse ; the difference was never great, not being more than a few tenths of a degree in any case. Recently 0. Weber has hit on a new method of measurement, the thermoelectric : by his very difficult investigations the question seemed to be decided that the inflamed part is always warmer than the arterial blood ; indeed, that the venous blood coming from the seat of inflammation is warmer than the arterial blood going to it. Quite recently these investigations were repeated in Konigsberg by H. Jacobson, M. Bernhardt, and G. Zaudien, with the final re- sult of showing no increase of warmth in the inflamed part. From the contradiction of the results of observation it is impossible to form a judgment on this point. Nevertheless it seems certain that in the in- flamed part there is not enough heat produced to elevate the tempera- ture of all the blood in the body several degrees. 2. The irritation induced by the inflammation on the nerves of the inflamed part might be supposed as advancing to the centres of the vasomotor (nutrient) nerves ; the excitement of the centres of these 92 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. nerves would induce increase of the general change of tissue and con- sequent increase of the production of warmth. This hypothesis, which is supported by some facts, such as the great difference in febrile irri- tability, and which I formerly maintained, no longer appears to me tenable ; it is opposed by the experimental researches of Breuer and Chrobak, which prove that fever occurred even when all the nerves were divided, by which there could be any conduction from the periph- eral injury to the nerve-centres ; the recent investigations oi Ley den also oppose this hypothesis, since they prove that there is no constant re- lation between the loss of nitrogenous material, or consumption, and development of warmth. 3. Since, from the nature of the process, in the inflamed part some of the tissue is destro}- ed, while some new tissue is formed, it is not improbable that some of the products of this destruction enter the blood, partly through the blood-vessels, partly through the lymph- vessels ; such material acts as a ferment, excites change in the blood, as a consequence of which the entire amount of blood may be Avarmed. We might also admit a more complicated mode of development of warmth, which, by including the nervous system, might in some re- spects be more serviceable theoretically ; the blood changed by taking up the product of irritation might prove irritant to the centres of the vaso-motor nerves, and thus induce increased production of warmth. The decision between these different hypotheses is difficult ; they are all about equally justifiable, and all have the common factor of pollu- tion of the blood by material from the seat of inflammation or the wound, which is recognized as having an effect on the production of heat ; these substances must have the effect of exciting fever (a pyrogenous action). This was to be proved. It has been proved by experiments of 0. Weber and myself, which I can notice only briefly here. In most open wounds, especially in contused wounds, shreds of tissue are always decomposed ; in many idiopathic inflam- mations, the circulation is arrested at different points in the inflamed tissue, and there is partial decomposition of these dead portions. Decomposing tissue, then, was an object to be examined in regard to its pyrogenous action. If you inject filtered infusions of this substance into the blood of animals, they have high fever, and not unfrequently die with symptoms of debility, of somnolence, with coin- cident bloody diarrhoea. The same effect is induced by fresh pus in- jected into the blood ; a weaker effect follows the employment of juice and pus serum pressed out of the inflamed part, but the secretion from the wound taken during the first forty-eight hours is especially active. Hence the products of decomposition, as well as those of new formation, have a pyrogenous action in the blood. These prod- ucts are of a very complicated and variable nature ; some of the PYROGENOUS MATERIALS. 93 chemical substances in them have been independently tested in re- gard to their fever-exciting qualities : we may induce fever by inject- ing leucin, sulphuretted hydrogen, sulphides of ammonium and car- bon, and other chemical substances resulting from the decomposition of tissue, or even b} 7 " injecting water ; decomposing vegetable matter also has a fever-exciting effect. Hence there are no specific fever- exciting substances, but the number of pyrogenous materials is in- numerable. I may here mention that the bad-smelling substances developed by the decomposition of the tissues are probably the least dangerous. I intentionally distinguish the products of decomposition in acute inflammations, which are usually odorless at first (whose activity as poisons we first learned by experiment), from those of decomposing dead bodies, which generally smell bad at once, although their pyro- genous action is similar. If a wounded patient has fever, it is for me a proof that there is decomposition going on in his wound, and that the products have passed into the blood, whether the wound smells or not. After the pyrogenous effect of the products of inflammation and decomposition had been absolutely confirmed, it remained to be proved that this material could be taken from the tissue into the blood, and to be shown how this took place. For this purpose it was injected into the subcutaneous cellular tissue, where it spread around in the meshes of the tissue ; the effect, as to fever, was the same as when the injection was made directly into the blood ; hence the pyrogenous material is absorbed from the cellular tissue. Here there is another observation to be made : after a time, at the point where decomposing' fluid or fresh pus has been injected, there is severe and not unfrequently rapidly progressive inflammation. For instance, I injected half an ounce of decomposing fluid into the thigh of a horse ; in twenty-four hours the whole leg was swollen, hot, and painful, and the animal very feverish. I did the same thing with the same result, with fresh (not decomposing) abscess pus, in a dog. This action of pus and putrefy- ing matter in exciting local inflammation I call phlogogenous. All pyrogenous substances are not at the same time phlogogenous ; some are more so than others, and, especially in the putrefying fluids, it makes a great deal of difference whether the poisonous power, which we do not know accurately, is present in greater or less quantities. It is not certainly determined whether the pyrogenous materials enter the blood through the lymph or blood-vessels; they may vary in this respect. Some points are in favor of the reabsorption taking place chiefly through the lymphatics. 5 There is still something to be said about the course of the fever 94 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. artificially induced in animals. The fever begins very soon, often even in an hour after the injection ; after two hours there is always considerable elevation of temperature : for instance, in a dog whose temperature in the rectum was 103° F., two hours after an injection of pus it may be 105°, and four hours after the injection lO? . It is im- material whether the substance be injected directly into the blood or into the cellular tissue. The fever may remain at its height from one to twelve hours, or even longer. The defervescence may be either gradually or by crisis. If we make new injections, the fever increases again ; by repeated injections of putrefying material we may kill the largest animal in a few days. Whether an animal shall die from a single experiment, depends on the amount and poisonous qualities of the injected material in relation to the size of the animal. A medium- sized dog, after the injection of a scruple of filtered decomposing fluid, may be feverish for a few hours and be perfectly well after twelve hours. Hence the poison may be eliminated by the change of tissue, and the disturbances induced by its presence in the blood may again subside. I will now terminate these observations, and only hope I may have made this important subject, to which we shall frequently return, comprehensible to you. I feel convinced that traumatic fever, like any inflammatory fever, essentially depends on a poisoned state of the blood, and may be induced by various materials passing from the seat of inflammation into the blood. In the accidental traumatic diseases we shall again take up this question. Now a few words about the prognosis and treatment of suppurat- ing wounds. The prognosis o£ simple incised wounds of the soft parts depends chiefly on the physiological importance of the wounded part, both as regards its importance in the body and as regards the disturbance of function in the part itself. You will readily understand that injuries of the medulla oblongata, of the heart, and of large arterial trunks lying deep in the cavities of the body, should be absolutely fatal. Injuries of the brain heal rarely; the same is true of injuries of the spinal medulla — they almost always induce extensive paralysis and prove fatal by various secondary diseases. Injuries of large nervous trunks result in paralysis of the part of the body lying below the seat of injury. Openings into the cavities of the body are always very serious wounds; should they be accompanied by injury of the lung, intestines, liver, spleen, kidney, or bladder, the danger increases ; many of these injuries are absolutely fatal. Opening of the large joints is also an injury which not only often impairs the function of TREATMENT OF SIMPLE INCISED WOUNDS. 95 the joint, but is often dangerous to life from its secondary effects. External circumstances, the constitution and temperament of the pa- tient, have also a certain influence on the course of cure. Another source of danger is the accessory diseases which subsequently arise, and of which unfortunately there are many ; of these we shall here- after speak in a separate chapter. You must for the time being con- tent yourselves with these indications, whose further elucidation forms a very considerable part of clinical surgery. We may give the treatment of simple incised wounds very briefly. We have already spoken of the uniting of wounds without loss of substance, and the proper time for removing the sutures, and that is about all that we can regard as directly affecting the process of heal- ing. Still, as in all rational therapeutics, here it is most important : 1. To prevent injurious influences that may interfere with the nor- mal course ; 2. Carefully to watch the occurrence of deviations from the normal, and to combat them at the right time, if possible. If we, first of all, limit ourselves to local treatment, we have no remedy for decidedly shortening the process of healing by first inten- tion or by suppuration, say to half its time'or less. Nevertheless, most wounds require certain care, although innumerable slight wounds heal without being seen by a surgeon. The first requirement for normal healing is absolute rest of the injured part, especially if the wound has extended through the skin into the muscles. Hence, in wounds at all deep, it is very necessary that the patient should not only keep his chamber, but that he should remain in bed for a time, as it is evident that the movement of injured parts, especially of in- jured muscles, must interfere with the process of healing. The sec- ond important point is cleanliness of the wound and its vicinity. Formerly it was always considered necessary to cover the wound, and to apply dressings in all cases. Of late I have grown doubtful if this be indeed necessary ; indeed, I would go so far as to assert that in many cases it is well not to apply any dressings. In wounds that have been sewed up, it has often been observed that it does no harm to leave them uncovered. If we wish to cover sutured wounds, on account of pain, redness, and swelling, or because they are in a part of the body upon which the patient must lie, we may apply various kinds of dressing ; we may smear the edges of the wound with pure, fine oil, best with almond-oil, and lay on a fold of linen dipped in oil, which should be changed daily, till the sutures are removed ; or else we may apply a linen compress three or four layers thick, and the size of the wound, wet with water, and cover it with oil-silk, gutta- percha sheeting, or parchment-paper, and make a few loose turns of a bandage over it. 96 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. For some time past I have used as the immediate covering of recent wounds merely a moistened thin sheet of gutta-percha, over this a moist compress ; and to prevent the latter from drying, I cover it with some waterproof stuff, such as glazed paper, gutta- percha, or oiled silk, and then cover with plenty of dry wadding (de- prived of fat and made bibulous by cooking in lye). This dressing may be removed without wetting or giving pain ; it is to be retained in place by a bandage or adhesive plaster. For moistening the compresses and the sheet of gutta-percha, which lies directly on the wound, we generally employ liquids which arrest the decomposition of the secretion from the wound and prevent its smelling badly, that is, which are antiseptics and deodorants, and at the same time may destroy any infectious matters clinging to the dressings. In my clinic, for this purpose we employ saturated solution of chloride of lime, aqua plumbi, solutions of carbolic acid, carbolate of soda, and sulphate of soda (10 per cent.). I have not noticed any decided difference in their effect, and on the score of economy use solution of chloride of lime for ordinary dressings. The frequency with which the dressings of a simple wound should be renewed depends on the amount of secretion. As a general rule, during the first four days the dressing above described should be removed at least twice daily ; if during the first and second days the secretion escapes in a few hours, the dressing should be changed at once. In doing this we no longer need to use a syringe, and to carefully work off the charpie from the wound, while the patient suffers tortures ; should it ever be necessary to inject fistulous wounds, of which we shall hereafter speak, we may use either a sim- ple syringe or an HJsmarcNs douche, which consists of a cylindrical vessel 25 centimetres high and 12 in diameter, with a short tube in- serted at its bottom, on to which a rubber tube with a nozzle is applied ; when this vessel is held up by an attendant, it acts as a syringe. It is generally enough to wipe off the wound with a little wadding when changing the dressing, and it is not necessary to remove every trace of pus. In many cases this dressing may be continued for weeks, being after a time applied only once daily, and then every two or three days ; cicatrization goes on and the wound heals without doing any thing more. Nevertheless, independent of certain diseases of the granulations, of which we shall speak more particularly hereafter, it frequently happens that under a continuance of the same treatment the heal- ing is arrested ; for days the process of cicatrization does not ad- vance, and the granulating surface assumes a flabby appearance. TREATMENT OF SIMPLE INCISED WOUNDS. 97 Under such circumstances it is advisable to change the dressing, to irritate the granulating surface by new remedies. These temporary arrests of improvement occur in almost every large wound. Under such circumstances you may order fomentations of warm camomile- tea ; several compresses may be dipped in the warm tea, wrung out, and from time to time applied fresh to the wound ; or you may pre- scribe lotions of lead-water. You may also paint the wound from time to time with a solution of nitrate of silver (two to five grains to the ounce of water). If the wound-surface be no longer large, you may finally make use of salves ; these should be spread thinly over charpie or linen ; the most suitable are the basilicon-ointment (compound resin cerate, consisting of oil, wax, resin, suet, and turpentine) and a salve of nitrate of silver (one grain to a drachm of any salve, with the addition of Peruvian balsam). If the cicatrization be already far advanced, we may employ zinc-salve (zinc, oxide 3 j, ung. aq. rosse I j), or let the dry charpie adhere, and have the last portion of the wound heal under the scab. A very peculiar and occasionally a very efficient method of hast- ening cicatrization of granulating wounds lias been introduced by Meverdin. He found that a small portion of cutis taken from the surface of the body with concave scissors, and fastened with the raw surface on the granulations by means of adhesive plasters, not only becomes adherent, but the transplanted epidermis begins to grow and forms the centre of a so-called cicatricial island, whence the skin- ning over of the wound advances just as it does from the margins. In the clinic we have often resorted to this artificial skinning over of wounds with epidermis, and rarely ineffectually. The effect is perceived when we remove the plaster on the third day and find a red aureola around the transplanted piece ; this gradually grows, and on the sixth or eighth day is followed by a bluish-white border, just as in cicatrization at the edges of the wound. I do not underestimate the practical value of this proceeding, but it is even more interesting to me from the addition it forms to our knowledge of natural history. Here we have the most striking proof not only of the independence of cell-life in the tissues of man, but still more of the readily-excited formative power of the epithelium, which is here aroused by a change of the nutrient material, while the portion of the papillary layer of the cutis transplanted at the same time does not grow. Thiersch, Minnich, and Menzel have made observations showing that, eight hours or perhaps longer after death, epidermis may be successfully transplanted. The finer details of the histological changes in these transplantations have been carefully studied by Heverdin, and still more so by Amabile. Czemy has shown that 7 98 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. mucous membrane from the mouth (with flat epithelium) and from the nose (with cylindrical ciliated epithelium) may be successfully grafted on wounds. [Is this, perhaps, one cause for animals licking their wounds ?] The epithelium of these membranes preserves its character but a short time, then it is transformed into epidermis. [March 6, 1871, Dr. B. Howard presented, at the meeting of the New York County Medical Society, a case in which, after skin-grafting, cicatrization had progressed for a time, then seemed to be arrested ; whereupon he grafted small portions of the biceps muscle and thus induced a continuance of the cicatrization. The question was raised whether the renewed activity was not due to the previous skin-graft- ing. Dr. Stein stated that he had aroused these old ulcers by sprin- kling epidermis scales over their surface.] Regarding constitutional treatment, we can accomplish scarcely any thing with internal remedies in preventing or cutting short the sub- sequent fever. Still, certain dietetic rules are necessary. After the injury the patient should not overload his stomach, but, as long as he has fever, must live on low diet. This he usually does spontane- ously, as fever patients rarely have any appetite ; but, even after subsidence of the fever, the patient should not live too high, but only eat as much as he can digest while lying in bed or confined to his chamber, where he has no exercise. If the fever be high, and the patient desires some change of drink from cold water, which is generally preferred by fever patients, you may order acid drinks, as lemonade or some medicinal substance ; the patients soon grow tired of the ordinary lemonade ; they bear phosphoric or muriatic acid in water with fruit-juice, raspberry-vinegar in water, apple boiled in water, toast-water (infusion of toasted bread with some lemon-juice and sugar) ; some patients prefer almond-mucilage, water-ice dis- solved in water, oatmeal gruel, barley-water, etc. We may give the taste of the patient full play ; but it is well for you to attend to such things yourself. The physician should know as much about the cel- lar and kitchen as about the apothecary-shop, and it is even well for him to have the reputation of being a gourmand. HEALING BY FIRST AND SECOND INTENTION. 99 LECTURE IX. Combination of Healing by First and Second Intention.— Union of Granulation Surfaces. — Healing under a Scab. — Granulation Diseases. — The Cicatrix in various Tissues; in Muscle ; in Nerve ; its knobby Proliferation ; in Vessels. — Organization of the Thrombus. — Arterial, collateral Circulation. To-day I have first simply to add a few words about certain de- viations from the ordinary course of healing, which occur so fre- quently that they must very often be counted as normal; at all events, as very frequent. It is not at all unfrequent for the two forms of healing above de- scribed, by first and second intention, to combine in the same wound. For instance, you unite a wound completely, and may sometimes ob- serve that at some places there is healing by the first intention, while at others, after removal of the sutures, the wound gapes, and subse- quently heals by suppuration. But it is much more common for a large and deep wound to heal superficially, and to suppurate for some time from the deeper part. If the entire surface of the wound be healthy, the cause of the in- complete healing is either that it was imperfectly coapted at the first dressing, or that blood and exudation escaped between the edges, which not only do not coagulate firmly enough to keep up the adhesion, but can even decompose and set up an inflammation which may spread rapidly and cause severe general disturbances. These important results of such wounds compel us specially to study their mechanical conditions and chemical changes ; from the first they are more or less complete fistulous wounds. It may be readily seen that where the skin has been divided, as for the removal of a deeply -situated tumor or a portion of diseased bone, a cavity is left if the skin is sewed up, which will remain filled with air and blood, unless the bleeding has been completely arrested, the wound well cleansed, and its edges brought well in contact. In cases where different tissues are wounded, and contract unequally, as in a wound going down to the bone, the surfaces would be very uneven and not be accurately apposed if the edges of the skin were simply united. Experience teaches that in such cases large wounded surfaces, even if loosely approximated, may be readily separated by secondary hemorrhages or fluid exudations, which often decompose while the skin above them is completely united. Then the parts around the wound swell and become painful, and high fever comes on. I will not here describe those dangerous states, septic phleg- mon and blood-poisoning, which may arise, but merely say that we 100 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. may often prevent the development of these processes by early evac- uation of the decomposing matter. It is not the mere presence of blood between the tissues that causes these affections, for that often occurs in severe contusions without wounds and induces no bad re- sults ; it is the decomposition of the blood, and the peculiarly phlogo- genous and pyrogenous properties of the first exudation, which cause the danger. Hence, in treating these wounds, we must take care, first, to prevent collection of blood and secretion in the wound, and secondly, in case this has not succeeded, to prevent decomposi- tion of these fluids, so that they may rest quietly until absorbed, as they would if the skin had not been injured. Of course, if there be no blood or secretion in the wound, they cannot decompose ; hence it is most important to prevent their col- lection. This would be most simply prevented by not closing up deep wounds, but filling them with charpie, wadding, or similar bib- ulous material, after carefully arresting the haemorrhage ; this dress- ing must be renewed as often as it becomes saturated. This method was used for years, and was considered satisfactory, as no other way was known ; still, as we now know better methods, we think the reaction was considerable, although less than accompanied the irri- tative treatment of the middle ages ; inflammations spreading from the wound were frequent, and were referred to individual peculiari- ties, then to general influences of the atmosphere or to hospital air. It is only within the last twenty years that the propriety of the above treatment has been questioned, and new ways, based on differ- ent hypotheses, have been sought. This led to two opposite meth- ods : one entirely without dressings (open treatment of wounds), the other accurate closure and air-tight dressing (method by occlu- sion). In the open treatment of wounds, which can only be used with facility in wounds of the extremities, the part is so placed that the secretion may flow readily into a vessel placed beneath. The first two days this secretion is of a dark blood-color and thin ; from the third to the fifth day it becomes light brownish, then yellow, and soon in the vessel the pus-serum separates from the lumpy flakes of pus-cells ; at the ordinary temperature of the room this secretion does not begin to smell badly in twenty-four hours, unless consider- able quantities of decomposing dead shreds of tissue lie in the wounds and pass off with the secretion. This freedom from smell must strike any one who has smelt dressings that have been removed from a wound after being applied twenty-four hours. The bodily tem- perature to which this secretion is subjected while in the dressing is doubtless the cause of its more rapid decomposition. Should one a priori suppose that with such a dressing collection of the secretion .OPEN TREATMENT OF WOUNDS. 101 with its evil results would be impossible, he will soon find practi- cally that the object of the open treatment of wounds will not be attained by absolute inattention, but that the form and position of the wound may greatly impede the escape of secretion, and also that the early, firm union of the skin may shut off certain parts of the wound as effectually as if a suture had been introduced, and thus the same severe diseases may be induced as by the old methods of treatment. In operations we may do much to make wounds of such a shape that the secretions will run off at once ; but in accidental wounds this is often difficult to do, and requires a certain experi- ence. In regard to the above-mentioned formation of pockets, we should prevent it by daily breaking up the adhesion, or from the first lay drainage-tubes in all the angles and hollows of the wound, through which any secretion from the deeper parts may readily es- cape. These drainage-tubes, introduced by Chassaignac, are made of vulcanized rubber of various calibre, with holes along the sides. The term " drainage " is taken from agriculture ; land may be drained by laying a system of porous tubes at a certain depth through the soil; the water trickles into these tubes, and flows through them to large ditches. The results from careful trial of this method of open treatment for years far surpassed all previous ones. From the publications of JBartscher, Vezin, and JBurow, I had my attention called to this plan over ten years ago ; and as it fully agreed with the views I had arrived at from clinical and experi- mental observations and investigations on the poisonous peculiarities of the first secretion from wounds, I have pursued it with particular care, and have resorted to it in almost all deep wounds of the ex- tremities, whether incised or contused. It was only after being assured by some of the most prominent German surgeons that better results were obtained by Listens careful antiseptic dressing that I would try it, so little did I think of the correctness of the theory. There is no doubt that it would be a great advantage for the pa- tient and a triumph for surgery if we could without danger induce healing by first intention in all large deep wounds. It is true, even in the open treatment of wounds, the surfaces may so come in con- tact as to heal almost entirely by first intention ; but this is rare, although partial adhesions are frequent and do not require breaking up if the patient remain free from fever and pain. Formerly, by applying bandages to press the surfaces of the wound together, or by deep sutures, attempts were made to induce immediate union ; although this succeeded in some cases, it proved so dangerous in those where the surfaces of the wound were separated by blood or exudation, which putrified and could not escape, that conscientious 102 SIMPLE INCISED WOUNDS OF THE SOFT PAKTS. surgeons soon abandoned it. Subsequently, when attempts were made by laying strips of oiled rag in the angle of the wound to give exit to the secretion, it rarely succeeded. In my opinion Lis- ter deserves great credit for having shown that numerous drainage- tubes, properly placed in the wound and cut off even with the sur- face, will completely carry off all secretion, even if an accurately- fitting compressive dressing of bibulous material be applied over the united wound ; if, by directly covering the wound with gutta-percha or oiled silk, we prevent the drainage-tubes from being stuck up by dried secretion, such a dressing has the advantage of an open dress- ing, by allowing free escape of secretion, as well as that of a com- pressing dressing, by which union of large wounded surfaces is so greatly favored. To prevent the escaping secretion from decom- posing in the dressing and affecting the wound, the dressing should be frequently changed at first. In this care about dressings, as well as in cleanliness about operations, it seems to me, lies the great ad- vantage of Listens method. But Lister started on the construction of his complicated dressing from different ideas ; he thought, just as I have repeatedly asserted, that the severe inflammations about wounds and the constitutional implications are almost always due to decomposition in the wound. I think that decomposition of dying tissue and exudation from the wound (for us a decomposition of albuminous substances with formation of pyrogenous and phlogoge- nous matters) is a chemical process that must, under certain circum- stances, always occur in these substances without the addition of new agents ; while Lister agrees with Pasteur's view that decompo- sition only occurs under the influence of small vegetable organisms, just as he claims that fermentation is only developed by yeast fun- gus. In regard to this question of living or dead ferments, I must refer you to organic chemistry. In physiology you have learned about salivary, pancreatic, and gastric ferments, which, although produced by cell-activity, no longer act as living organisms, but in a purely chemical way. In the same way, I think a substance may be formed as the last action of a dying tissue, that shall have some of the peculiarities of a ferment, and at the same time have a phlogo- genous action, and perhaps be very poisonous for the circulating blood. It does not seem to me to have been proved that the addi- tion of small organisms (vibriones or bacteria of Pasteur) is abso- lutely necessary to the formation of such substances. It is true, they are generally found in such fluids ; but this may be explained by the fact that these small organisms occur everywhere in air and water, and develop particularly in decomposing fluids. As we shall often have occasion to speak of these small organ- ORGANIC FERMENTS IN WOUNDS. 103 isms, whose significance is at present so much discussed, I will here give you a brief sketch of those forms that are most frequently found in decomposing tissues and fluids. They may be minute spheres (micrococcus, from [iLKpbg, small, and 6 ftotacog, the germ), or minute rods (bacteria, from to fiafcrripLOV, the rod), which may be isolated, in pairs, or in chains of from 4 to 20 links (streptococcus, from 6 OTpenrbg, the chain, and 6 KOKKog) ; often they are held in the shape of a sphere or cylinder by a glutinous substance which they throw out (coccoglia, from kokkoc; and rj yXia or yXocd, glue). Fig. 17 a. ° o O °o »<.« o*, 5b a, Micrococcus (Monads of Hueter, Microspores of Klebs) ; &, Coccog'lia or Gliacoccus (Zoogloea, Cohn) ; c, Streptococcus (Torula) ; d, Bacteria ; e, Vibriones ; /, Streptobacteria (Leptothrix of Rallier). Magnified 300-500 These elements vary greatly in size, from a pale sphere, of such diameter that it can scarcely be perceived with the highest power of a microscope, to the size of a pus-cell ; they are sometimes mova- ble, at others quiet. It is pretty generally agreed that these minute organisms are vegetable in their nature, and belong to the algas ; but their accurate botanical position and relations to each other are still matters of dispute ; their development is not yet explained, and until very recently some believed that they were the result of generatio cequivoca or abiogenesis, that is, existed without influence from any living organism. From my investigations, I think that all the above forms belong to one plant, which, being composed of coc- cus and bacteria, and being found chiefly in decomposing fluids, I have called Coccobacteria septica. This plant seems to me to de- velop as follows : first, its germs are found in dry air, and may be 104 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. recognized under the microscope as fine dust ; placed in water, they swell and throw out more or less small pale spheres, micrococcus (a, Fig. 21 a). According to external circumstances, these assume the following forms : 1. While increasing by segmentation, they throw out a slimy cement (glia), by which they hang together in balls, like frog-spawn (coccoglia, or gliacoccus, b, Fig. 21 a) ; on the surface of fluids this form often appears as coherent bright-brownish mem- branes, and it also grows into the interstices of tissues, and is found as whitish-gray flakes in fluids ; this form is always without motion. Under certain circumstances the glia around these spheres and cyl- inders thickens to a membrane, the coccus becomes movable and es- capes through an opening in the capsule (ascococcus, from aoicog, tube). 2. The coccus divides always in one direction, and some of the divisions remain, like frog-spawn, united by a delicate envelope of glia (c, Fig. 21 a) ; these streptococci are sometimes in motion, wriggling slowly across the field of the microscope, but usually they are at rest ; we may find them in fresh secretion from the wound or in pus, and often in alkaline urine, without there being necessarily any bad odor ; the streptococcus, along with the isolated micrococ- cus and gliacoccus, are the forms of coccobacteria which occur most frequently in decomposing secretion from wounds or in diphtheria of wounds. "With absolute rest the streptococcus may form long upright filaments, but this is very rare in living organisms, and is difficult to see under the microscope. 3. The coccus grows to rods, which increase in length and then divide across ; thus we lave bacteria chains (f, Fig. 21 a), which may be moving or motionless. In some fluids the division of the bacteria goes on very rapidly, the rods becoming shorter, till they are finally square or rounded ; and so between coccus and bacteria there are numerous transition forms, Bacteria are not apt to enter the secretion from wounds, pus, or decomposing blood ; on the other hand, they develop and remain in all fluids of the cadaver and in watery exudations of almost all tis- sues ; in the latter they are very movable. All of these vegetations require plenty of water and organic substances, especially nitrogenous matters, for their rapid propaga- tion ; they bear abstraction of water up to a certain point, but if entirely dried out they die ; and although they will subsequently swell if placed in water, they have lost their power of vegetating. They can bear temperatures as low as the freezing point, and nearly up to the boiling point ; but when it reaches the boiling point they die. In fluids or moist tissues completely excluded from atmos- pheric air, they will vegetate till all the air contained in the fluid has been used up ; then, no more air being absorbed by the fluid, ORGANIC FERMENTS IN WOUNDS. 105 the coccobacteria die, as they cannot canse decomposition of water or any organized combination. Under these conditions some of these coccobacteria may be thrown into the atmosphere and be generally distributed by the evaporation of fluids, so common in nature. Still, when the air be- comes very dry, these vegetations might dry out, die, and become organic but no longer organizable dust ; but such an occurrence is provided against. As in many of the algae of stagnant water, hav- ing similar peculiarities and subject to being dried out, so in some of the elements of coccobacteria a larger quantity of peculiarly con- centrated protoplasm unites to form a glistening sphere with dark contours, which may be distinguished from other coccus, but hardly from fat globules. These little spheres have the peculiarities of fungus-germs and very resistant seeds ; thej 7 may be entirely dried, cooled far below the freezing and warmed above the boiling point, and kept hermetically closed for a long time, without losing their germinal activity ; hence they are called permanent germs (JDauer- sporen). According to my experience, they form very certainly and not very rarely, under certain circumstances, in bacteria ; but they also occur in coccoglia balls ; I cannot state whether some spheres of streptococcus also become permanent germs. These Dauersporen are the dried germs from which we started for development ; they require quiet in or on some fluid or moist body. I have here given you a brief review of the results to which my investigations on this point have led. But I must call attention to the fact that botanists have not yet proved the correctness of my views, and that they are at variance with those of most others who have investigated this subject, and who consider each of the forms above described as separate plants, and also make numerous species of each kind, especially according to the diseases induced by each. Let me also remind you that most pathologists term these algae fungi, and often call them all bacteria. It is to these small organisms that Pasteur, and after him Lister, attributes decomposition, at least those forms of it whose products are local and general poisons. If we could prevent their entrance into the wound or its secretions, according to this view, there would be no decomposition of the secretions, even if some of them did re- main in the wound. With this idea, Lister writes a number of rules to be followed in the operation and dressing of the wound, all aim- ing at the destruction of the germs of coccobacteria which might reach the wound through the hands of the operator and assistants or the air. After the operator and assistants, before each operation or dressing, have carefully washed with soap and water, they dip their 106 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. hands in a five per cent, solution of carbolic acid ; in the same way the parts about the seat of operation are to be carefully washed and moistened with the same solution of carbolic acid; and all instru- ments, sponges, and dressings used lie in this solution, which is sup- posed to kill all germs of coccobacteria. To prevent these germs from reaching the wound through the air during the operation and dressing, a two per cent, solution of carbolic acid is constantly sprayed on the part with a special apparatus, so that it falls on the wound in the form of a fine rain. We have already described the occlusion or "antiseptic" dressing, as it is termed, although the open treatment of wounds and some other methods are just as anti- septic. There is no reason for going any further into details here, where we are chiefly explaining principles. Listens dressing, which seems so complicated, is in practice much simpler than would appear from the description ; for every step and rule the inventor had a definite reason, and there is nothing arbitrary or intentionally mys- terious. If we inquire into the practical working of this treatment, we hear chiefly praise, and many speak enthusiastically of its won- derful effects. Although my own experience with it is not very great, I can recommend it as being generally very good ; it is cer- tainly more popular than the open treatment of wounds ; it is still a disputed point which of these methods answers best in treatment of wounds of the extremities. I urgently recommend you to perfect yourselves in the principles and practical application of Lister's treatment, and you will have many favorable results. It is different if we accurately examine the correctness of the theoretical views from which Lister starts, and inquire whether by his mode of operating and dressing he has attained his object. In regard to the latter point, it has been often proved that in the secre- tion of wounds treated according to Listens method, and which healed rapidly without reaction, coccobacteria were found about as often as in secretion from wounds which were merely dressed with attention to cleanliness. This shows : 1, that the presence of these vegetations in itself proves nothing about the phlogogenous or other poisonous qualities of the secretion ; 2, that Lister's dressing is no guarantee for the destruction of bacteria. Against this second point it might be urged that there is no proof that these germs reach the wound only from without; it is possible that permanent germs enter the blood through the respired air, and, though they may not develop under normal circumstances, do so in the secretion of wounds. If this be possible, there is no sense in the theory of Lister's method as far as regards its attacking organic germs by chemical means. Indeed, it is my opinion that those not very frequent cases where HEALING BY THIRD INTENTION. 10 7 coccobacteria vegetations have been found in completely closed deeply-seated points of inflammation, which never communicated with the air, can only be explained in the way above mentioned. Apart from the fact that Lister's dressing is expensive if followed out in all its details, and that more or less severe poisoning is often caused by the annoying dermatitis induced by the carbolic acid, this incongruence of theory and practice has led to the employment of more and more dilute solutions of carbolic acid, and its replacement by other antiseptic and less irritating acids and salts (salicylic acid, Thiersch ; sulphide of sodium, Minich). Various changes have also been made in the mode of applying the dressing ( Volkmann, Bardeleben) ; the spray has been entirely omitted, and in its place after the operation the wound has been washed with a more concen- trated antiseptic solution, etc., etc. Thus Lister's dressing has been variously modified, and from each modification the same favor- able results have been obtained as from the original dressing. This confirms me in the opinion formed when this method was first de- scribed, and which I have already stated, that the scrupulous clean- liness and the careful removal of secretion from the wound is the most important part of it, and that it is chiefly popular among sur- geons who formerly paid less attention to these points, and left the dressings to the dirty hands of nurses or to careless students or young physicians, while now the dressings are all applied according to definite principles of cleanliness. Moreover, the constantly spreading and more energetically preached doctrine of local infection from wounds, of which we shall treat hereafter, has led to a rec- ognition of the necessity of a rational treatment of wounds, and has contributed essentially to opening the way for the open treat- ment of wounds — to Lister's method and antiseptic lotions. There is still another mode of adhesion of the edges of wounds, which consists in the direct union of two adjacent granulating sur- faces. This mode of healing, which you may call healing by the third intention, is unfortunately very rare. The reason of this is evident : pus is constantly secreted from the surface of the granulations, and while this goes on the surfaces are only apparently in contact, for there is pus between them. Occasionally, it is true, we may, by press- ing the two granulation surfaces together, prevent the further forma- tion of pus, and then the two surfaces may adhere ; we accomplish this by drawing the flaps of the wound firmly together with good adhesive plaster, or by the application of secondary sutures, for which it is well to employ wire. Unfortunately, the attempt to hasten the cure by 108 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. these means so rarely succeeds, that they are only exceptionally em- ployed. The best results are obtained from secondary sutures when, six or seven days after the injury, they are applied about four or five lines from the edge of the wound, because the tissue is then more dense and firm, and the sutures cut through less quickly. There is still another mode of healing, viz., healing of a superficial wound under a scab. This only occurs frequently in small wounds, that secrete but little pus, for in these alone does the pus dry on the wound to a firmly-attached scab ; in profuse suppuration it is true the superficial layer of the pus may dry by evaporation of the watery portion, but, while new pus is constantly being secreted under it, it cannot form an adherent, consistent scab. When such a scab has formed, the granulation tissue develops to only a very small amount un- der it ; perhaps because on account of the slight pressure of the scab, the granulation tissue is less mucous, so that the epidermis can more readily regenerate under the scab ; such a small wound may be wholly cicatrized when the scab falls. The granulation surface may assume a totally different appearance from that above described, especially in large wounds. There are certain diseases of the granulations, whose marked forms I shall briefly sketch for you, although the varieties are so numerous that you will only learn them from individual observation. We may divide granulation surfaces as follows : 1. Proliferating fungous granulations. The expression " fungous ' means nothing more than " spongy ; " hence by fungous granulations we mean those that rise above the level of the skin, and lie over the edges of the wound, like fungus or sponge. They are usually very soft ; the pus secreted is mucous, glairy, tenacious ; it contains fewer cells than good pus, and most of the pus-cells, like granulation-cells, are filled with numerous fat-globules and mucous material, which is also more abundant than normal as intercellular substance ; and in these granulations Mindfleisch also discovered collections of Virchoufa mucous tissue, fully developed. The development of vessels may be very prolific ; the fragile tissue often bleeds on the slightest touch ; occasionally the granulations are of a very dark blue. In ofher cases the development of vessels is very scanty, often to such a degree that the surface is light red, or in spots has even a yellowish, gelatinous appearance, in very anaemic persons, often also in young children and very old persons. The most frequent cause of development of such proliferating granulations is any local impediment to the healing of the wound, such as rigidity of the surrounding skin, so that the con DISEASES OF THE GRANULATIONS. 109 traction of the cicatrix is difficult ; a foreign body at the bottom of a tubular granulating wound (a fistula) ; this abnormal proliferation is also particularly apt to occur in large wounds, which can only contract slowly ; it appears as if the activity of the tissue was occasionally ex- hausted, and no longer capable of continuing the requisite condensa- tion and cicatrization, so that it only produces relaxed, spongy granu- lations. As long as there are granulations of the above character, rising above the edges of the skin, cicatrization does not usually pro- gress. The wound would probably heal, but not for a very long time. We have plenty of remedies for hastening the healing under such cir- cumstances ; these are especially caustics, by which we partly destroy the granulation surface, and thus excite a stronger growth from the depth. At first you may cauterize the granulating surface daily, es- pecially along the edges, with nitrate of silver, whereupon a white slough will quickly form, which will become detached in twelve to twenty-four hours, or even sooner; repeat this cauterization as re- quired, till the granulating surface is even. Another very good rem- edy is sprinkling the wound with powdered red precipitate of mercury . (hydrar. oxyd. rubrum), which also should be repeated daily, to im- prove the granulating surface. Compression with adhesive plasters also acts very well occasionally. If the granulations be exceedingly dense and large, we often may succeed soonest by cutting some of them off with the scissors ; the consequent haemorrhage is readily arrested by applying charpie. Where the proliferation is less, as- tringent lotions, such as decoction of oak-bark, cinchona-bark, lead- water, etc., may answer to excite the sluggish cicatrization. 2. By erethitic granulations we mean those characterized by great pain on the slightest provocation ; they are usually very proliferant granulations, which readily bleed; it is a very rare condition. In excessive erethism of the granulations, they are so sensitive that they cannot endure the slightest touch or any dressing ; a less degree of sen- sitiveness of the granulations is not so rare. On what it depends, is not very certain ; granulation tissue itself has no nerves ; in most cases touching it causes no sensation, only the conduction of the pressure to the subjacent nerves causes sensation. In the above excessive sensibil- ity, probably the ends of the nerves at the floor of the wound are degen- erated in a peculiar manner ; perhaps there are miniature thickenings of the finest nerve-ends, like those that we shall hereafter see on large nerve-trunks. It would be a thankworthy task to make a careful ex- amination of this question. We occasionally observe similar condi- tions in the cicatrices in large nerves, and shall speak of this hereafter. For this very painful sensitiveness, which not only interferes with healing, but greatly worries the patient, you may first try soothing 110 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. ointments, almond-oil, spermaceti-ointment, or simple cataplasms of boiled oatmeal or linseed-meal, or warm-water compresses. The nar- cotic compresses or cataplasms, made with the addition of belladonna or hyoscyamus-leaves, are of little benefit. If these applications do not answer, do not delay destroying the entire granulating surface, or at least the painful part, with caustic (nitrate of silver, caustic potash, or the hot iron), with the patient anaesthetized, or else excising the entire surface with the knife. If the great painfulness be due to hys- teria, anaemia, etc., you will not attain much by any local remedies, but should try to assuage the general irritability by internal remedies, such as valerian, assafcetida, iron, quinine, warm baths, etc. • 3. In large wounds, especially in fistula granulations, a yellow rind sometimes forms on part of the granulation surface, which may be readily detached, and on careful examination is found to consist of pus cells, very firmly attached together. Although I have sometimes found coagulating filaments between the cells, they do not always occur, hence we must suppose that the cell-body, the protoplasm itself, is transformed into fibrine, as occurs in true croup, and especially in the formation of fibrinous deposits on serous membranes. Here there is also a croup of the granulations. The croupous membrane reforms even a few hours after its removal, and this is repeated for several . days, till it either disappears spontaneously, or finally ceases on cau- terization of the affected part. Very similar white spots are occasion- ally found on larger granulation surfaces, which are probably not caused by fibrinous deposits, but by local obstruction of the blood- vessels. Under peculiar, unfavorable conditions, both states may re- sult in destruction of the granulations, in a true diphtheria of the wound, which we shall hereafter treat of as hospital gangrene. For- tunately, however, it rarely goes on to this disease, but the state of the wound improves again after a time, and the recovery takes the usual course. If disease of the granulating surface be accompanied by swelling, great pain, and fever, we have a true acute inflammation of the wound; then the mucous granulation substance sometimes coagulates through- out to a fibrinous mass ; the wound-surface looks yellow and greasy. I shall treat of the causes of these secondary inflammations under the head of contused wounds. Usually the croupous inflammation, which has affected part or the entire surface of a wound, ends in sloughing of the diseased granulations, whereupon new granulations spring from the depths. It cannot be denied that the perfectly local, superficial, and inter- stitial deposit of fibrine strongly supports the view that Virchow has proposed for croupous processes generally. It was formerly sup DISEASES OF THE GRANULATIONS. m posed that in all inflammatory croupous process, especially in the ordinary form of acute inflammation of the lungs and pleura, the blood was over-rich in fibrine ; that there was a fibrinous crasis in the blood, as a result of which, the excessive fibrine escaping from the capillaries, coagulates partly on, partly in, the inflamed surface, and so led to the formation of these pseudomembranous deposits. ~Vir- chow, on the other hand, proposed the idea that, by the inflammatory process, the tissue may be placed in a condition to cause coagulation of the fibrinous solution infiltrating it. I cannot here enter more par- ticularly into the various grounds on which Virchow bases this view, but shall only call attention to the fact that in the case in question (of fibrinous exudation on the granulating surface), at least there can be no rapidly coming and evanescent fibrous crasis of the blood ; but evidently it is a local process which may readily be removed by local remedies. According to the repeatedly-mentioned observations of A. Schmidt, we may infer that in certain quantitative and qualitative irritations of the tissue, more fibrogenous tissue than usual escapes from the capillaries. Virchow had even previously called attention to the fact that, from repeated irritation, simple serous exudation may become fibrinous or croupous. If you apply a spanish-fly blister to the skin, a vesicle filled with serous fluid forms — the superficial layer being lifted from the rete mucosum by the rapidly-forming serous exu- dation ; if we remove the vesicle and reapply the blister, in many . cases after a few hours we shall find the surface covered with a fibrin- ous layer, which contains innumerable newly-formed cells ; indeed, is almost entirely composed of them. We may attain the same result by applying the plaster to skin already inflamed, or to a young cicatrix. The treatment of croupous inflammation of the granulations is purely local ; we should carefully seek for any causes of new irrita- tion, and try to remove them. Daily remove the fibrinous rinds, and cauterize the exposed surface with nitrate of silver, or paint it with tincture of iodine, and you will soon see this abnormal state of the granulating surface disappear. 4. Besides the above diseases of the granulations, there is occa- sionally a state of perfect relaxation and collapse, in which they pre- sent an even, red, smooth, shiny surface, from which the nodular, granular appearance has entirely disappeared, and, instead of pus, a thin watery serum is secreted. This state almost always occurs in the granulations at the end of life ; as already mentioned, you always find it in the cadaver. It is still necessary to add something about the cicatrices, con- cerning certain subsequent changes in them, their proliferation and their shape in different tissues. 112 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. Linear cicatrices of wounds, that have healed by first intention, rarely undergo subsequent degeneration. Large, broad cicatrices, especially when they lie immediately on the bone, often open again ; the epidermis, which is tender at first, being torn off by motion or by the least blow or friction, and there is superficial atrophy, an excoria- tion of the cicatrix. Sometimes the young epidermis is elevated like a vesicle, by exudation from the vessels of the cicatrix; there may also be some haemorrhage, so that the vesicle will be filled with bloody serum. Then, after removing the vesicle, you have an excoriation, as after simple rubbing off of epidermis. This opening of the cicatrix, if often repeated, may prove very annoying to the patient. You pre- vent this most readily by causing the patient to protect the young cicatrix for a time with wadding or a bandage. If the excoriation nas taken place, apply only mild dressings : oil, glycerine, zinc-salve, etc., or emplastrum cerussa. In these cases, irritating salves enlarge the wound, and consequently should be avoided. If the granulating surface be once perfectly covered with epider- mis, as already stated, the retrogressive changes to solid connective tissue take place in the cicatrix, and it atrophies. But in rare cases the cicatrix grows independently, and develops to a firm connective- tissue tumor. This is seen almost exclusively in small wounds that have long suppurated and been covered with spongy granulations, over which the epidermis formed exceptionally. You know it is the custom to pierce the ear-lobes of little girls, so that they may subse- quently wear ear-rings. This little operation is done with a coarse needle by the mother or the jeweller, and a small ear-ring is at once introduced through the fresh puncture. As a rule, this puncture soon heals — the ring preventing the closure of the opening. But in other cases there are active inflammation and suppuration ; indeed, if the suppuration continue, the ring may cut downward through the lobe ; granulations develop at the openings of entrance and exit ; finally, the trial is given up, and the ring removed ; then the opening often heals quickly. In other cases the granulations cicatrize, the cicatrix continues to grow, and on both sides of the lobe of the ear small connective-tissue tumors, small fibroids, form. These look like a thick shirt-button drawn through the hole of the ear, and they grow inde- pendently like a tumor. If you examine these tumors, on section you find them of pure white tendinous appearance, like the cicatrix itself. Microscopically the tissue is found to consist of connective tissue with numerous cells ; it is simply a proliferation, an hypertrophy of the cicatrix. I have seen this twice in the ear ; another case is mentioned by Dieffenbach in his operative surgery. I once saw similar tumors on the back of the neck, where they had formed at the CHANGES IN CICATRICES. 113 openings made for a seton ; they were about the size of a horse- chestnut. They should be carefully removed with the knife, and any subsequent granulations kept in subjection by nitrate of silver. [The translator has seen the above tumors on the lobe of the ear several times ; in all but two instances they occurred in mulatto females ; in one case the tumor had returned after a previous re- moval.] In the above description of the formation of granulations and cica- trices, for the sake of simplicity we have only referred to the process as it is found in connective tissue, but must now speak of it as it occurs in cicatrization of other tissues. The cicatrix in muscle is at first almost entirely connective tissue ; Fig. 18. Cicatrix from the upper lip of a dog. «, connective tissue of the cicatrix. The divided muscular fibres are here atrophied for a short distance, and terminate in a conical shape. Magni- fied 300 diameters. in the ends of the muscular fibres there is at first destruction, then at a certain boundary a collection of nuclei ; then there is rounding off of the fibres, sometimes club-shaped, sometimes of more conical form, and the stumps of the muscular fibres unite with the connective tissue of the cicatrix just as they do with the tendons ; the muscle cicatrix becomes an inscriptio tendinea. I myself have only observed them in wounds of muscle that had healed by first intention, and have never there seen any thing that I could decide was a new formation of mus- cular tissue. In suppurating ends of muscle, 0. Weber has witnessed a slight formation of new muscle ; this appears to occur chiefly in for- mation of granulations on muscle and in certain tumors. Weber is of the opinion that young muscular fibres typically form 8 114 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. from the cells of old ones, but considers it impossible to prove that no muscular cells originate from other young cells. As a result of his examination of old muscular cicatrices, he also maintains that the re- generation continues a long time, and in most cases is more complete than is generally supposed. Maslowshy has affirmed the metamor- Fiq. 19. Ends of divided mascular fibres from the biceps muscle of a rabbit eight days after the injury; a be, old muscular fibres; a, the contractile substance rolled up and balled together; the same way in the bundle above d; the same with the sarcolemma drawn out to a point; c, into the pointed cornet-shaped sarcolemma tube extends a series of young muscular nuclei, between which there is very delicate transversly striated substance; e, the same with young, free muscle-cells ; /, two young ribbon-like muscular filaments ; g, the same of vari- ous size isolated. Magnified 450 diameters ; after 0. Weber. phosis of wandering cells to muscle-cells ; but I consider the cinnabar method employed by him as insufficient to prove this assertion. [Cin- nabar or vermilion injected into the blood is taken up by white cor- puscles, and may afterward be discovered on inflamed tissue.] Gussenbauer has shown that, after injury, the muscular filaments usually break down into flakes, and then new young muscle-cells form, after the type of embryonal development, from the cells con- tained in the old muscle-filaments ; the amount of the new formation depends on the quality and duration of the irritation. If a nerve be divided, its ends separate, from their elasticity, they swell slightly, and subsequently unite by development of a new forma- tion of true nerve-tissue, so that the nerve is again capable of conduc- CICATRICES IN MUSCLES AND NERVES. 115 tion through the cicatrix. In large superficial cicatrices, new nerves develop ; when you have excised portions of skin and have brought to- gether and united parts lying at a distance, new nerves grow through the cicatrix and perfect power of conduction comes after a time, as may be often observed in plastic operations. These facts are very Fig. 20. Regenerative processes in transversely-striated muscular fibres after injury. Magnified about 500, after Gussenbauer. remarkable, and physiologically are still entirely inexplicable. Just think how wonderful that these nerve-filaments, sensory and motor, should find each other in the new adhesion, and that even, as we must suppose, the stumps of the primitive fibres should unite as they had been united, so that correct conduction and localization might result as they actually do ! We cannot here go more exactly into this sub- ject. I will only mention that the more minute process, which has been very carefully followed by Schiff, Hjelt, and others, is generally as follows : first, in the stump of the nerve there is a destruction of the nerve-sheath, possibly also of the axis cylinder to a certain extent ; at the same time in the neurilemma there is a collection of cells, which proceeds to the development of spindle-shaped cells in the sub- stance lying between the ends of the nerve, and extending into the 116 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. stump. From these cells, just as in the embryo during intra-uterine life, new nerve- fibrillae develop upward and downward; the filaments, which are at first very pale, subsequently acquire a sheath, and then cannot be distinguished from ordinary nerve-filaments. The most recent FlG - 21 - Fig. 22, investigations as to the significance of wandering cells in new formation of tis- sue, as well as the special studies over the formation of nerves in portions of tadpoles' tails regen- erated after injury, have made me doubt the former view, that young regenerated nerve-filaments were composed of spindle- Kegeneration of nerve?. Fig. 21, from a rabbit fifteen days after Cells. It Seems to me division ; young spindle-cells in the end of the nerve developed , , ,, from the connective tissue aDd intimately connected with the much more probable neurilemma. Fig. 22, from the frog ten weeks after division; ,i , .1 A' 'A A development of young nerve-cells from the spindle-cells. Mag- tnat tne CUVlQeQ axis- nified 306 diameters, after Hjelt. cylinders grow out in- to young nerve-filaments, and that the elongated spindle-cells, which undoubtedly exist in the nerve-callus in certain stages, either belong to the connective tissue of the neurilemma or are detached portions of young nerve-filaments containing nuclei. The last investigations of Neumann and Eichhorst confirm pre- vious ones in regard to the immediate results of division, but show that the young nerve-filaments grow directly from the axis-cylinder, as well from the central as from the distal part, meet together, and blend, as the offshoots from a capillary wall sink into the wall of another vessel, and so may form a communicating canal between two vessels {Arnold). The process in the wounded nerve corresponds most beautifully with that in wounded muscle. In the muscular as in the nervous filament several young filaments sprout from one primitive filament [a, Fig. 22 A ; compare Fig. 20). So it is shown that muscles, vessels, nerves, and epithelium- are not regenerated from proliferating connective-tissue cells or wan- dering cells, but from throwing out offshoots from their tissue, or from cells derived from the protoplasm of their tissue. It is very probable that connective-tissue cells also, especially those still con- CICATRICES IN MUSCLES AND NERVES. 117 taining protoplasm, send out offshoots at the wounded part in which nuclei subsequently form, as is done in the nerves of the tadpole's tail. This point should be investigated again ; till then we may re- gard wandering cells as the source of the young regenerated tissue. Since Schwann's teaching about the development of tissue from cells, we are so convinced that every new tissue proceeds from young cells, that the announcement of independent growth of a perfect tissue without intervention of cells finds little credit ; and the increase Nerve of a rabbit: a, seventeen days after division; 6, fifty days; c, frog's nerve, thirty days nified about 600. After Mchhorst. Mag- of cells by offshoots, with subsequent development of nuclei in these offshoots, is a procedure that histologists have long kept in the background, substituting for it cell-division, although botanists have ascribed a very prominent r61e to this mode of development in plants. From' the latest published observations we see that the capillary walls, the axis-cylinder of nerves, and the contents of mus- cular filaments possess this capacity for outgrowth without direct participation of new cells. Rohitansky ascribed to connective tis- sue the capacity for independent outgrowth. Tn the human being the regeneration of nerves only takes place within certain limits, which, it is true, cannot be very accurately de- fined. The complete regeneration of large nerve-trunks, as of the sciatic or median nerves, does not occur ; nor does it take place after excision of large portions of nerve, if the ends remain, say three or four lines apart. Very accurate apposition of the ends of the nerve is necessary, for apparently the transformation of the newly-formed intermediate substance to nerve-substance can only take place by means of the nerve-stump, although there are different opinions about 118 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. the mode of this process ; we shall see similar conditions in the heal- ing of broken bones, where bony union only follows accurate coapta- tion of the fragments. Now, how is it in this respect with brain and spinal tissue ? In the human being there is no regeneration here after injury, or after loss of substance from idiopathic inflammation, or at least not sufficient to restore the power of conduction. In animals, indeed, as Mrown-Sequard has shown in pigeons, after dividing the spinal marrow, there may be regeneration with disappearance of the paralysis, which has of course occurred in all parts below the point of division. Unfortunately, this power of regeneration of nerves decreases in proportion to the higher development of the vertebrate animals, and it is least in man. As is known, in young salamanders whole extremities grow again when they have been amputated. "What a pity this is not so in man ! However, as regards the nerves, Nature occasionally seems to make a fruitless attempt at regeneration ; for quite often the nerve-ends in amputation-stumps, instead of simply cicatrizing, develop to club-shaped nodules, which are occasionally ex- cessively painful, and require subsequent excision. These nodules on the nerves consist of an entanglement of the primitive nerve-filaments, which develop from the stump of the nerve as if they would grow to meet opposite nerve-ends. The cicatrices in the continuity of nerves also are sometimes nodular from the formation of convoluted primitive filaments. Such small nerve-tumors (true neuromata) are occasion- ally excessively painful, and must be removed with the knife. But there are also traumatic neuromata, which are not at all painful, as I have seen in old amputation-stumps. In general, these proliferations of nerve-cicatrices are to be compared with the previously-mentioned hypertrophy of connective - tissue cicatrices, and with proliferating bone, which, although rarely, is formed in great excess in the healing of broken bones. The process of healing after injury of great vessels, especially of arterial trunks, has been carefully determined by experiment. If a large artery be ligated in an amputation or for disease in its continu- ity, as the ligature is drawn tight, the tunica intima is ruptured, and the tunica muscularis and adventitia are so constricted that their inner surfaces folded up lie in exact apposition. You may satisfy yourselves of the frequent although not necessarily universal rupture of the in- ternal tunic, by ligating a large arterial trunk in the cadaver, for you not unfrequently experience a slight grating or crackling under the finger when tightening the ligature ; you may also see it on cutting open a ligated artery after detachment of the ligature. From the point of ligation to the next branch leaving the artery, both at the cen- tral and peripheral ends, the calibre of the vessel fills with coagulated FORMATION OF THROMBUS. 119 Pio. 28. Nodular nerve-terminations in an old amputation-stump of the arm. From a preparation in the Anatomical Museum at Bonn. Copied after Froriep, " Surgical Copperplates." Bd. I., Taf. 113. blood, the so-called thrombus (from 5 $pofi(3og, the blood-clot). The enveloping ligature kills the enclosed tissue, which gradually breaks down into pus, and when this process is completed the ligature falls, or, as we technically express it, " the ligature has cut through," " comes away." When this has taken place, the calibre of the artery must be permanently and certainly closed, or there will at once be another haemorrhage. Under unfavorable circumstances it may certainly happen, in small as well as in arteries of medium or large size, that the ligature cuts through too soon, and then dangerous, sudden secondary haemor- rhage occurs. We may foresee this if the wall of the artery was dis- eased ; often calcined arteries cannot be ligated, as the ligature does not compress them or cuts through them at once ; sometimes the ar' tery is softened (as, for instance, when part of its course has been through the wall of a large abscess) so that on ligation the ligature cuts through and must be applied farther up. But unfortunately, in perfectly healthy subjects, as I found in the last war, haemorrhages too often occur from the point of ligation of large arteries, where carefully-applied ligatures cut through before the organic closure was firm enough to resist the current of blood ; this greatly impairs the value of such operations, which are often temporarily necessary to save the patient's life. 120 SIMPLE INCISED WOUNDS OF THE SOFT PAKTS. Fig. 24. Artery ligated in the continuity. Throm- bus; after Froriep. Passing now to the consideration of what has taken place in the end of the vessel from the coagulation of the blood till the firm closure, experiments on animals and accidental observations on man have given the following : the blood-clot at first lying loose in the vessel gradually becomes more firmly attached to the wall of the vessel, and con- stantly grows harder, but still remains red for a long time ; it does not lose its color for weeks or months, and then does so first in the centre, so that the rest of it still retains a slight yellowish tinge. After the detachment of the ligature, the thrombus is so hard and so firmly attached to the walls of the vessel that the calibre is entirely closed. The preparation (Fig. 24) shows you the thrombus formation in an artery after ligation in the continuity; the lower thrombus reaches to the point of departure of the first branch, the upper one not so far ; the former is the rule as laid down in most books, the latter is a not uncommon exception. Plugging of the artery by a blood-clot, which becomes firm, is, however, only a provisional state, for the thrombus does not remain so for all future time, but the cicatricial tissue shrinks and atrophies ; this takes place in the course of months and years, at which time the closure of the artery at the point of division has become solid by adhesion of the walls of the vessel. If you examine such an artery a few months after the ligation, you find nothing of the thrombus ; but the artery termi- nates in a conical point of cicatricial connective tissue. The above changes, which we may follow with the naked eye, show that in the blood-clot there is a change which essentially consists in its increasing firmness and coherence to the wall of the vessel ; we shall now study with the microscope on what this transformation of the blood-clot depends. If you examine the recent blood-clot, you find it to consist of red blood-corpuscles, a few colorless blood-cells, and of fine filaments and coagulated fibrine, arranged in irregular net- work. If you take a thrombus two days after the ligation of a small or medium-sized artery, it is firmer than at first, and is broken up with difficulty; the red blood-cells are little changed, the white ones are greatly increased ; they have sometimes two and three nuclei as pre- viously, sometimes single pale, oval nuclei with nucleoli; some of these cells are almost double the size of white blood-cells. The fine filaments of the fibrine are united to an almost homogeneous mass, which is difficult of division. If you again examine a thrombus six days old, the red blood-cells have almost disappeared, the fibrine is FORMATION OF THROMBUS. 121 more firm and homogeneous, and even more difficult to separate than previously ; a large number of spindle-shaped cells with oval nuclei, showing distinct divisions, appear. From the above, it appears that even quite early a number of living cells appear in the blood- clot, whose further development will be seen from what follows. Since we obtain a more accurate understanding of the changes in the thrombus and its relation to the arterial walls, by making transverse sections of the thrombosed artery, we shall proceed to do this. This preparation shows a transverse section of a recent throm- bus in a small artery; within, the delicate mosaic formed by the crowded red blood-corpuscles, among them a FlG - 25 - few round white blood-cells (which have been rendered visible by car- mine) ; next comes the tunica intima, laid together in regular folds, in which the blood-clot clings ; then the tunica muscularis ; then the tunica adventitia, with the net-work of elas- tic fibres ; to the right some adherent loose connective tissue. The next preparation (Fig. 26) is the transverse section of a human artery, closed with a thrombus for six days ; we see no Transverse section of a fresh thrombus. „ i ui^^j „«n„ . +1,^ „t1^+« ^„™ „„^ Magnified 300 diameters. red blood-cells ; the white ones are greatly increased, mostly round ; but, in the tunica adventitia and surrounding connective tissue, there has already been some cell infiltration. If we now examine a ten-day-old thrombus from a large muscular artery of the thigh of a man (Fig. 27, a), we find it already containing numerous spindle-cells, which are partly arranged in striae (subsequently vessels) ; the intercellular substance is filamentary, here rendered transparent by acetic acid. Finally, there is also formation of blood-vessels in the organized thrombus, as you see in the following preparations (Figs. 28 and 29). It has been established, by the investigations of 0. Weber, that the vessels of the thrombus communicate partly with the calibre of the thrombosed vessel, partly with its vasa vasorum. The process of healing in transversely-divided veins appears at the first glance to be much simpler than in the arteries ; even in the large veins of the extremities, the divided ends fall together, and ap- pear to heal at once, as soon as the blood has been obstructed at the next valve above ; at these valves clots form, and they are often much larger than is desirable ; this formation of clots extending toward the heart will hereafter occupy our earnest attention. But I have of late 122 SIMPLE INCISED WOUXDS OF THE SOFT PARTS. observed that the tunica intima of the divided vein does not by any means so fold together and adhere, but that here also there is a clot, although a small one, which is organized like the arterial thrombus. Fick 26. Transverse section of a thrombus six days old. 300 diameters. Fio. 27. Ten-day-old thrombus, a. Organized thrombus ; b. Tunica intima ; c, Tunica muscularis ; d, Tunica adventitia. 300 diameters. FORMATION OF THROMBUS. 123 If you draw conclusions from these preparations, presented in such a fragmentary way, it appears that in the clotted blood there is a cel- lular infiltration, which here leads to development of connective tissue ; in short, that the thrombus becomes organized. The thrombus is not a permanent tissue, but gradually disappears again, or, at least, is re- duced to a minimum, a fate which it shares with many new formations resulting from inflammation. Fig. 28. Completely-organized thrombus in the human arteria tibialis postica. a, Thrombus with ves- sels, perfectly united with the innermost layer of the intima; &, the lamellae of the tunica intima; c, the tunica muscularis, traversed by numerous connective tissue and elastic fila- ments ; d, Tunica adventitia. Magnified 300 diameters. After Bindfleisch. Peculiar reasons caused me to investigate more accurately the or- ganization of the thrombus. The importance of this process is rather extensive ; a point on which you cannot at present judge well, but will hereafter be in a position to estimate fully, when we come to treat of diseases of the vessels. From my investigations up to the present time, I do not think I dare retract the assertion that coagulated fibrine may, by aid of cells, be transformed into connective-tissue intercellular substance, although I cannot decide whether this be due to true metamorphosis, or to a gradual substitution of cell protoplasm for disappearing fibrine. Some have attempted to refer the origin of the cells, which appear in con- 124 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. stantly-increasing numbers in the thrombus, to the wall of the vessel; the arteries, as well as the veins, are coated with a lining of epithe- lium, which to some extent represents the innermost lamella of the tunica intima. These epithelial cells and the nuclei of the striated Fig. 29. Longitudinal section of the ligated end of the crural artery of a dog, fifty days after ligation ; the thrombus is injected; a a, tunica intima and media; b b, tunica adventitia. Magnified 40 diameters. lamellae of the intima have been claimed a priori by some authors, so that they could let new cells be formed from them, and grow into the thrombus ; in his last work, Thiersch also inclines to this view. I acknowledge that I myself formerly strongly combated the supposi- tion that the blood could of itself become organized to connective tissue with vessels ; but from examinations of transverse sections of thrombosed arteries, I am satisfied of its correctness. After having abandoned the idea of proliferation of stable tissue-cells in inflamma- tion, we can no longer talk of a proliferation of the intima in the old sense. But whence come, then, these newly-formed cells ? I have no doubt that they originate from the white blood-cells, which have been FORMATION OF THROMBUS. Fig. 30. a I 125 Portion of a transverse section of a human femoral vein, with an organized vascular thromhus, 18 days after amputation of the thigh ; a a, Tunica intima j b b, media ; c c, adventitia ; d d % enveloping cellular tissue ; Th, organized thromhus with vessels ; the layering of the fibrine is still distinctly visible in the periphery of the thrombus. Magnified 100 diameters. partly enclosed in the thrombus, partly may have wandered into it, according to the observations of Fi Recklinghausen and JBubnoff. As regards the red blood-cells, it seems that they gradually unite with the coagulated fibrine, lose their shape, become intercellular substance, and lose their coloring matter, which is separated as granules or crys- tals of hematoidin. Little as we know whence blood-cells come, and whither they go, still it is certain that the white cells enter the blood from the lymphatic vessels, and that they enter the latter from the lymphatic glands or connective tissue elsewhere ; they are cells that originate directly from connective-tissue cells, or from a protoplasm analogous to connective tissue. Are these cells still viable when en- closed in a blood-clot ? After coming to rest here, can they transform themselves to tissue ? It is impossible to affirm or deny these questions absolutely ; since Bubnoff has shown that wandering cells enter the thrombus, and may there continue their movements, there is no necessity for supposing that the white blood-cells (which are identical with wandering cells) enclosed in the thrombus, on coagula- 126 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. tion, no longer move, and cannot be transformed into tissue. Hith- erto there have been no investigations as to whether wandering cells pass through the walls of arteries as readily as through those of veins, as JBubnoff^s investigations only refer to venous thrombi. Some of my investigations in this direction showed me that minute cinnabar granules passed through the carotid of a dog into the thrombus, but I could not satisfy myself that they were replaced by wandering cells. So at present it is uncertain whence the numerous wandering cells in an organizing arterial thrombus originate, and how they enter there. Tschausoff) in a very carefully-studied work that has lately appeared, calls attention to the fact that a great portion of large thrombi are destroyed by disintegration. This is very true, but he goes too far when he entirely denies the provisional organization of the thrombus, and supposes that the disintegration of the clot is immediately fol- lowed by the adhesion of the walls of the vessel, to which I have called attention as the definite termination of the whole process. 6 As I have already stated, peculiarly favorable conditions are re* quisite for the blood-clot to become organized. It is an absolute law in the human organism, that non-vascular tissues, which are nourished by means of cells alone, have no great extent ; the articular cartilages, the cornea, the tunica intima of these vessels, the tissues, are all in thin layers ; in other words, the cells of the human body cannot, like those of plants, carry nutrient fluid to any given distance, but are limited in their conductive power ; at certain distances new blood-vessels must appear, to supply and carry off the nutrient fluid. The blood-clot, consisting of cells with coagulated fibrine, is at first a non-vascula* cellular tissue, which can only maintain its existence in thin layers. This appears from observations, which we shall hereafter often have occasion to mention ; namely, that large blood-clots are not organized at all, or only in their peripheral layers, while they disintegrate in the centre. From this it appears that, in healing by the first intention, a small amount of blood lying between the edges of the wound does no harm, while a larger amount interferes with healing, or prevents it altogether. You will soon be able to verify this observation in the clinic. The formation and organization of the thrombus have engaged the attention of surgeons and anatomists since the time of John Hunter and even yet they are not fully understood. We must con- sider them here on account of their general histogenetic interest, al- though of late it is doubtful whether thrombi are practically as im- portant for the results of ligation as was formerly supposed. Even Porta called attention to the fact that the quick adhesion and union of the tissue around the ligated artery was as important as organiza- tion of the thrombus. Surgeons have kept this point well in view, CIRCULATION AFTER LIGATION. 127 always striving, by most carefully operating and attending to the wound, to attain healing by the first intention. But it was the suc- cess of acupressure which first showed clearly that the adhesion of the tissues by coagulable exudation even in forty-eight hours is enough to keep securely the compressed or twisted artery, even when it is the size of the femoral. Although ITocher has shown that, even after acupressure, thrombi occur in arteries, yet they are too small to check bleeding in a large artery within forty-eight hours. Hence, even from this point of view, attempts to replace the ligature by other methods, which leave no threads in the wound but permit its entire closure by first intention, should be encouraged without denying in any way the extraordinary advantages of the ligature. Let us now look at the fate of the circulation after ligating a large artery in the continuity. Suppose that, for a haemorrhage in the leg, the femoral artery has been ligated ; how does the blood now reach the leg ? how will the circulation go on ? Just as on closure of capil- lary districts, under increased pressure, the blood presses through the next permeable vessels, which are thereby dilated ; the same thing occurs on closure of small or medium-sized arteries. Under increased pressure, the blood flows through the branches close above the thrombus, and from the numerous arterial anastomoses, both in the Fig. 32. Fig. 31. Carotid artery of a rabbit, injected 6 weeks after ligation. After Porto. Carotid artery of a goat, injected 35 months after ligation. Af- ter Porta. 128 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. Fig. 33. long axis and various transverse axes of the limb, reaches other arteries, through which it soon again streams into the peripheral end of the ligat- ed vessel. An arterial collateral circulation is established to the side of the ligated and thrombosed portion of the arterial trunk. Without this, the part of the body lying below this point would not receive suffi- cient blood and would die ; it would dry up or putrefy. Fortunately, arterial anastomoses are so free that, even after ligation of a large artery, like the axillary or femoral, such a case is not apt to occur ; in diseased arteries, however, which do not distend sufficiently, mortifi- cation of the affected extremity may occur. The modes in which these new vascular connections form vary greatly. Years ago, Porta made very profound researches on this point, and from his numerous experiments stated the following, as the types of collateral circula- tion: 1. Direct collateral circulation is established; i. e., there are strongly-developed vessels, which pass from the central end of the artery directly to the peripheral end. These uniting vessels are chiefly the dilated vasa vasorum, and the vessels of the thrombus ; it might happen that one of these uniting vessels should di- late so much as to acquire the appearance of being simply the trunk regenerated. 2. There is an indirect col- lateral circulation ; i. e., the connecting branches of the next lateral arteries are greatly di- lated, as in the following case, Fig. 33. The most striking examples of both varieties of collateral circulation have here been cho- sen ; but when you examine the numerous sketches of Porta, and yourselves repeat these ex- periments, you will find that in most cases direct and indirect collateral circulation are com- bined, so the only value of the classification is to group the different forms in some way. It is an excellent anatomi- Femoral artery of a large dog, injected 3 months after ligation. Att er Porta. CIRCULATION AFTER LIGATION. 129 cal exercise, to represent for yourselves how, after ligation of the different arteries of one or both extremities, or of the trunk, the blood will reach the parts beyond the point of ligation ; in this you would be well assisted by the plates of arterial anastomosis in Krauze's text-book of anatomy. In the surgery of old Conrad Martin Lan- genbecJc, these conditions are carefully described in the chapter on aneurisms. The reversal of the blood-current, which not unfrequently takes place in these collateral circulations, occurs with wonderful rapidity, when the anastomoses are free ; if, for instance, we ligate the common carotid in a man, and then divide the artery beyond the liga- ture, the blood escapes with great force from the peripheral end, that is, backward as from a vein. In all such cases, where the artery to be ligated has free anastomoses, if a piece is to be cut out of the artery, we should first ligate both central and peripheral ends, to be insured against haemorrhage ; this is an important practical rule, which is often neglected. CHAPTER II. SOME PECULIARITIES OF PUNCTURED WOUNDS. LECTURE X As a Eule, Punctured Wounds heal quickly by First Intention. — Needle Punctures ; Needles remaining in the Body, their Extraction. — Punctured Wounds of the Nerves. — Punctured Wounds of the Arteries : Aneurysma Traumaticum, Varicosum, Varix Aneurysmaticus. — Punctured Wounds of the Veins, Venesection. Most punctured wounds are simple wounds, and usually heal by first intention ; many of them are at the same time incised wounds, when the puncturing instrument has a certain breadth ; some have the characteristics of contused wounds, when the puncturing instru- ment was blunt ; in this case there is generally more or less suppura- tion. "We make many punctured wounds with our surgical instru- ments, as with acupuncture needles — fine, long needles, that we occasionally employ to examine whether and how deep below a tumor or ulcer the bone is destroyed, etc. ; with acupressure needles, which we use for arresting haemorrhage ; with the trocar, a dagger with a three- sided point, furnished with a closely-fitting canula, an instrument for drawing off fluid from cavities. Dirk, sword, knife, and bayonet punctures are often simultaneously incised and contused wounds. If these punctured wounds be not accompanied by injury of large arteries, veins, or bones, and do not enter any of the cavities of the body, they often heal rapidly and without treatment. The most frequent punctured wounds are those made with needles, especially in women, and how rarely a doctor is called for them ! Such an injury is only complicated by a needle, or a part of one, en- tering the soft parts so deeply that it cannot readily be extracted. This occasionally happens in different parts of the body, as from a person sitting or falling on a needle, or some such accident. If a needle has entered deep under the skin, the symptoms are usually so NEEDLE WOUNDS. 131 slight that the patients rarely have any decided sensation of it ; in- deed, they often cannot say whether the needle has really entered, and where it is. And in the soft parts this body usually induces no external symptoms, but may be carried in the body for months, years, or even a lifetime, without trouble, if it do not enter a nerve. The needle rarely remains stationary at the point where it entered, but wanders about ; it is shoved along to other parts of the body by con- traction of the muscles, and thus may come to light a long distance from the point of entrance. Cases have been observed where hyster- ical women, from the peculiar vanity of attracting the attention of physicians, have inserted numerous needles in different parts of the body; these needles appeared now here, now there. Even when needles have been swallowed, they may without danger pass through the walls of the stomach and intestines, and come to the surface at any part of the abdominal wall. JB. von LangenbecJc found a pin in the centre of a vesical calculus ; on more careful inquiry, it was found that, when a child, the patient had swallowed a pin. The pin may have passed through the intestine into the bladder ; here triple phos- phates were deposited around it in layers, and this was possibly the origin of the calculus. Dittle had a similar experience. When the needle has remained for a time in the soft parts without exciting pain, or when needles, passing through the body from within outward, come to the surface close under the skin, they usually excite a little suppuration ; the piercing feeling becomes more decided ; we make an incision at the painful spot, let out a little thin pus, and in the pus-cavity find the needle, which may be readily removed with forceps. It is difficult to explain why this body, which for months has moved about in the body, should at length excite suppuration when it arrives under the skin ; you must here satisfy yourselves with a simple knowledge of the facts. The following interesting case may render the course of these injuries more clear to you : In Zurich a perfectly idiotic female deaf mute, thirty years old, was brought to the clinic with the diagnosis : typhus. No history of the case could be obtained from the patient or those about her, who were also lack- ing in intelligence. The patient, who often remained in bed for days, had complained for a short time of pain in the ileo-caecal region, and had moderate fever. Examination showed a swelling at this point, which increased the following days, and was very painful on pressure ; the skin reddened, fluctuation became evident. It was clearly not a case of typhus, but you may imagine what different diagnoses there were as to the seat of the suppuration, for there was undoubtedly an abscess ; it might be inflammation of the ovary, perforation of the vermiform process, an abscess in the abdominal walls, etc., etc. ; still. 132 SOME PECULIARITIES OF PUNCTURED WOUNDS. something could be said against all these hypotheses. After a few days the reddened skin became very thin, the abscess pointed about the height of the anterior superior spinous process of the ilium, a few fingers' breadths above Poupart's ligament, and I made an incision through the skin ; there was evacuated a gassy, brownish, sanious pus, with a strong fecal odor. As I examined the abscess-cavity with my finger, I felt a hard, rod-like, firm body in the depth of the abscess, and projecting slightly into it. I began to extract it, and pulled and pulled till I brought out a knitting-needle almost a foot long, which was somewhat rusty and pointed down toward the pelvis. The ab- scess-cavity was clothed with flabby granulations. When I tried to examine the opening that the needle must have left behind, I could no longer find it ; it had closed again, and was covered by the granu- lations. The abscess took a long time to heal; it at last did so without further accident, so that in four weeks the patient was dis- missed. As I showed the unfortunate cretin the extracted needle, she laughed in her idiotic way ; that was all we could make out of her ; perhaps this may have indicated some slight recollection of the needle. It is most probable that the patient had inserted the needle into the vagina or rectum — procedures in which even women not idiotic find some incredible pleasure, as you may see in Dieffenbach's operative surgery in the chapter on extraction of foreign bodies. It is not im- possible that in this case the needle passed by the side of the vaginal portion of the uterus through the cascum, for, from the gas-containing pus of the abscess, we may decide that there was at least a temporary communication with the intestine. It is true this cannot be regarded as absolutely certain, for pus in the vicinity of the intestines by the development of stinking gases may putrefy, even when no communi- cation with the interior of the intestines exists or has existed. The extraction of recently-entered needles may be very difficult, especially as the patients are not unfrequently very undecided in their information about the location of the body, and occasionally from shame will not acknowledge how the needles (in the bladder, for in- stance) obtained entrance. We should, with the left hand, fix the spot where we shall most probably find the foreign body, carefully endeavoring to press the skin together in folds ; we must at the same time be careful that the needle does not again change its position while we are making the incision. Sometimes we feel the body more or less distinctly, and can cause pain by pressing on it ; these attempts must decide the point of our incision. After dividing the skin, we attempt to seize the needle with a pair of good dissecting forceps ; very tense bands of fascia may readily deceive us, especially about the fingers, for with forceps our sense of feeling is always uncertain. EXTRACTION OF FOREIGN BODIES. I33 If we cannot find the needle, we may move the parts some ; the needle is then sometimes moved into a position where it may be seized more readily. The extraction of foreign bodies requires a cer- tain amount of practice and manual dexterity, which we acquire only with time and practice ; here natural knack is of great service. Punctured wounds, made with instruments not very sharp, are occasionally interrupted in their process of healing. Externally they heal by first intention, but after a few days there are suppuration and inflammation in the deeper parts ; the wound either opens, and the whole tract of the wound suppurates, or the pus breaks through at some other point. This occurs particularly in cases where a foreign body, as the point of a knife, remains behind, or where the wound was made with a blunt instrument. In examining the wound, you should always bear in mind the possibility of a foreign body remain- ing behind, and, if possible, see the instrument with which the injury was done, and find exactly in what direction the instrument passed, so that you may know about what parts are injured. However, even in unfavorable cases there are occasionally very little inflammation and suppuration. A short time since a man came to the clinic who, a few days previously, had fallen a moderate height from a tree, lighting on his left arm, while engaged clipping the small branches. On the dor- sal surface, a few inches below the elbow, the arm was swollen ; on the volar surface, just above the wrist, there was a slight excoriation ; the arm could be extended and flexed without pain ; only pronation and supination were impaired and painful. There was no solution of continuity of the bones of the forearm ; the bones were certainly not broken through. At the swollen spot on the dorsal side, an inch below the elbow, immediately under the skin, we could, however, feel a firm body, which could be pressed back somewhat, but it at once returned to its old position. It felt just as if a piece of bone had been broken off lengthwise, and lay close under the skin. Incompre- hensible as it must seem for such a detachment of bone to occur by simply falling on the arm, without fracture of the radius or ulna, I nevertheless had the patient anaesthetized, and again made the at- tempt to press into position the suspected fragment ; but it did not succeed. As it lay so close under the skin that it would necessarily have perforated ere long, I made a small incision through the skin to extract it. To our great astonishment, I drew out, not a fragment of bone, but a small branch, five inches long, which was quite firmly held by the two bones of the forearm. It was incomprehensible how this twig could have entered the forearm; but, on more careful examination at the above-mentioned excoriated spot on the volar surface, we found a linear, slit-like wound, which had already closed, 134 SOME PECULIARITIES OF PUNCTURED WOUNDS. through which the body had apparently passed so quickly that the patient had not noticed its entrance. After its extraction the very moderate swelling entirely subsided; the small wound discharged but little pus, and was entirely closed in eight days. These favorable conditions of punctured wounds have given rise to the so-called subcutaneous operations, which were introduced into surgery more particularly by Stromeyer and Dieffenbach, and consist in passing a pointed, narrow knife under the skin, and dividing ten- dons, muscles, or nerves, for various purposes of treatment, without making any wound in the skin other than the small punctured wound through which the tenotome is introduced. Under these circum- stances the wound almost always quickly closes by first intention, while in open wounds of tendons there is almost always suppuration, often extensive death of the tendon. Of this we shall speak further in the chapter on deformities (Chapter XVIII.). If the puncture has entered one of the cavities of the body, and caused injury there, the prognosis will always be doubtful ; there is more or less danger, according to the physiological importance and vulnerability (the greater or less susceptibility to dangerous inflam- mation) of the organ implicated. Such a punctured wound is not so dangerous as a gunshot wound. We shall not at present pursue this subject further, but must now say something about punctured wounds of the nerves and arteries of the extremities. Punctured wounds of nerves naturally induce, according to their extent, paralysis of variable amount; otherwise they have the same effect as incised wounds of the nerves. Regeneration occurs the more readily when the whole breadth of the nerve has not been punc- tured. The case is different when a foreign body, as the point of a needle or a bit of glass, is left in the nerve-trunk ; they may heal in here as in other tissues. The cicatrix in the nerve which contains this body may remain excessively painful at every touch ; there may also be neuralgia or nervous pains extending excentrically. Moreover, the severest nervous diseases, acute or chronic, may be induced by these foreign bodies. ^Epileptiform spasms, with an aura, a pain in the cicatrix preceding the spasm, have been observed after such in- juries; some surgeons also assert that traumatic tetanus may also be induced by this nervous irritation. This appears to me very doubtful, but of this hereafter. The first of these diseases, the so-called reflex epilepsy, may usually be cured by the extraction of the foreign body. Punctured wounds of arterial trunks or their large branches may induce various results. A very small puncture usually closes by the elasticity and contractility of the coats ; indeed, there is not always a haemorrhage, any more than there is always escape of faeces from PUNCTURED WOUNDS OF ARTERIES. 135 a small puncture of the intestine. If the wound be slit-shaped, the bleeding may also be insignificant if the opening gapes but little ; but in other cases severe arterial haemorrhage is the immediate result. If compression be at once made, and a bandage accurately applied, we shall usually succeed not only in arresting the haemorrhage, but also in closing the puncture in the artery, just as we should one in the soft parts. If the bleeding be not arrested, as already stated, we should at once ligate the artery, after enlarging the wound up and downward, or at a higher point in the continuity. The closure of the arterial wound takes place as follows : A blood- clot forms in the more or less gaping wound of the arterial wall ; this clot projects slightly into the calibre of the vessel ; but externally it is usually somewhat larger, and looks like a mushroom. As described in intra-vascular thrombus, this clot is transformed to connective tissue ; and thus there is permanent organic closure, without change of the calibre of the artery. This normal course may be complicated FlG - 34 - by layers of new fibrine from the circulating blood, depositing on the part of the plug projecting into the calibre of the vessel, and ,1 -i • • , 1 i , j. • Artery wounded on the side, with clot, four thus closing it by a clot, forming a ftays after the injury; after Porta. complete arterial thrombosis; but this is rare. Should it happen, we would have the same result as after a thrombosis following ligation — development of collateral cir- culation, and eventual obliteration of the vessel by organization of the thrombus. Punctured wounds of the arteries do not always take so favorable a course. In many cases, soon after the injury, we notice a tumor at the seat of the young cutaneous cicatrix, which gradually enlarges and perceptibly pulsates isochronically with the systole of the heart and with the arterial pulse. If we place a stethoscope over the tumor, we may hear a distinct buzzing and friction sound. If we compress the chief artery of the extremity above the tumor, the pul- sation and murmur cease and the tumor diminishes somewhat. We call such a tumor an aneurism (from avevpyvetv, to dilate), and this particular form, arising from wound of an artery, we call aneurisma spurium or traumaticum, in contradistinction to the aneurisma verum, arising spontaneously from other diseases of the artery. Whence comes this tumor, and what is it ? Its origin is as fol- lows : The external wound is closed by pressure, the blood can no longer flow out of it ; but it forms a way through the opening, which is not yet firmly closed by the clot, into the soft parts, and winds 136 SOME PECULIARITIES OF PUNCTURED WOUNDS. about among them as long as the pressure of the blood is stronger than the resistance of the tissues ; a cavity filled with blood is formed in immediate communication with the calibre of the artery, part of the blood soon coagulates, and there is slight inflammation of the tissue about it ; a plastic infiltra- Pia « ^ tration, which leads to con- nective tissue new forma- tion, and this thickened tissue forms a sac, into and from whose cavity the blood flows, while the pe- riphery of the cavity is filled with layers of clotted blood. The buzzing and friction that we perceive in the tumor arise partly from the blood flowing out through the narrow open- ing in the artery, partly by its friction against the coagulum, and lastly by the regurgitation of the blood into the artery. Such a traumatic an- eurism may also occur in another, more secondary way ; the arterial wound at first heals, and subse- quently, after removal of the pressure bandage, the young cicatrix gives way, and then for the first time the blood escapes. Traumatic aneurisms are not always caused by punctured wounds of arteries, but rupture of their coats by great tension and contusions, without any external wound, may result in their development. Thus, in his surgical lectures, A. Cooper tells of a gentleman who leaped a ditch while out shooting, and at the time felt a pain in the hollow of his knee, which prevented his walking. An aneurism of the popliteal artery soon developed in the bend of the knee, that finally had to be operated on. The artery was partly ruptured by the leap. Rupture of the tunica intima and muscularis is sufficient to permit the forma- tion of an aneurism. Should the tunica adventitia remain uninjured, Aneurisma traamaticam of the brachial artery ; after Froriep, " Surgical Copperplates." Bd. IV., Plate 483. ANEURISM FROM PUNCTURED WOUNDS. 137 the blood may detach it from the tunica media ; this forms a variety of aneurism called aneurisma dissecans (dissecting aneurism). Cases of punctured wounds with subsequent aneurisms occur particularly in military practice, but not unfrequently also in civil practice. I saw a boy with an aneurism, as large as a hen's-egg, of the femoral artery, about the middle of the thigh, that had been caused by puncture with a pen-knife, on which the boy fell. A short time since I operated on an aneurism of the radial artery, that had developed in a shoemaker after an accidental puncture with an awl. An aneurism is a tumor communicating directly or indirectly with the calibre of an artery. This is the common definition. The communication is immediate in the case just described of a simple traumatic aneurism. Still, the anatomical conditions of this tumor may be more complicated. For instance, in a venesection at the bend of the elbow, that is, from intentionally puncturing a vein for the purpose of abstracting blood, besides the vein, the brachial artery may be wounded ; this is one of the most frequent causes of traumatic aneurism, or at least was so formerly, when bleeding was more common. In such a case, besides the dark, venous blood, we may readily perceive the bright, arterial blood ; the whole arm is at once bound up and the artery compressed, and in some cases the openings in both vessels heal at once without further consequences. But occasionally it happens that this accident is followed by an aneurism ; this may have the simple form above de- scribed ; but the openings in the two vessels may so grow together that part of the arterial blood will flow directly into the vein as into an arterial branch, and must then meet the stream of venous blood. This Fio. 36. Varix aneurismaticus. Brachial artery ; after Bell. Bd. in., Taf. 263. Froriep, "Surgical Copperplates." 138 SOME PECULIARITIES OF PUNCTURED WOUNDS. causes obstruction of the venous current and consequent sacculations, dilatations of the calibre of the vein, which we generally term vari' ces / in this particular case the varix is called varix aneurismaticus, because it communicates with an artery like an aneurism. Another case may arise : an aneurism forms between the artery and vein, both of which communicate with the aneurismal sac. Fio. 37. Aneurisma varicosum. a, Brachial artery: b, median vein. The aneurismal sac is cut open ; after Dorsey. Froriep, " Surgical Copperplates." Bd. III., Taf. 263. We call this aneurisma varicosum. There may also be some varieties in the relation of the aneurismal sac, vein, and artery, to each other, which, however, are only important as being curious, and change neither the symptoms nor treatment, and fortunately have no particular names. In all these cases where arterial blood flows directly or indi- rectly through an aneurismal sac into the veins, there is distention of the veins and a thrill in them, which may be both felt and heard, and may even be occasionally perceived in the arteries ; it probably results from the meeting of the currents. However, this thrill in the vessels is not characteristic of the above state, for it may sometimes be in- duced simply by pressure on the veins, and occurs in some diseases of the heart. We also occasionally see a weak pulsation in veins dis- tended by the above causes, which would even earlier give a correct diagnosis. Quite recently I saw a number of aneurisms resulting from gun- shot-wounds ; in three cases affecting the femoral and external iliac arteries, the above-mentioned thrill was very prominent, rendering it pretty certain that there was a communication between the artery and vein, as was proved by autopsy in one case ; but there were no varices in any of these cases ; hence their development is not a neces- VENESECTION. 139 sary result of communication between arteries and veins, or else they may in some cases not develop for some years. Aneurisms of the arteries, in whatever form they come, if they only remained small, would cause no great inconvenience. But in most cases the aneurismal sacs grow larger and larger ; functional dis- turbances occur in the affected extremity, and finally the aneurism may rupture, and a profuse haemorrhage terminate life. In most cases the treatment must consist in ligating the aneurismal artery ; but of this hereafter. I have considered it practical to explain to you here the development of traumatic aneurisms, as in practice they are mostly due to punctured wounds ; while in other text-books you will find them systematically treated of among diseases of the arteries. We shall speak, in a separate chapter, of spontaneous aneurisms and their treat- ment. Punctured wounds of veins heal just like those of arteries, so that I need add nothing here to what was said above ; we need only re- mark here that extensive coagulations form more readily in veins than in arteries; traumatic venous thrombosis after venesection, for in- stance, is far more frequent than traumatic arterial thrombosis after punctured wounds of arteries, and, what is far worse, the former variety of thrombosis has much more serious results than the latter ; on this point you will perhaps hereafter hear more than will be agreeable to you. We have frequently mentioned venesection, which is a very frequent small surgical operation. We shall here briefly review its performance, although you comprehend such things quicker and better by once see- ing them than I could represent them to you. Should I attempt to tell you under what circumstances venesection should be performed, I should have to enter deeply into the whole subject of medicine ; quite a large book might be written on the indications and contraindications, the admissibility, the benefits and injuries of venesection ; hence I pre- fer to say nothing on these points as on so many others which you will pick up in a few minutes at your daily visits to the clinics, and for whose theoretical exposition without special cases we should require hours. In regard to the history, we will only mention that, while for- merly venesection was performed on any of the subcutaneous veins, now it is only done in the veins of the bend of the elbow. If you wish to bleed a patient, you first apply a pressure-bandage to the arm, to cause obstruction of the peripheral veins ; for this purpose we em- ploy a properly-applied handkerchief or the old-fashioned scarlet bleed- ing-ribbon, a firm bandage two or three finger-breadths wide with a buckle ; when this is firmly applied the veins of the forearm swell up and the vena cephalica and basilica with their corresponding median 140 SOME PECULIARITIES OF PUNCTURED WOUNDS. veins appear in the bend of the elbow. You choose, for opening, the vein which is most prominent. The arm of the patient is flexed at an obtuse angle ; with the left thumb you fix the vein, with the lancet or a very pointed straight scalpel in the right hand you puncture the vein and slit it up longitudinally two or three lines. The blood escapes in a stream ; you allow sufficient to flow, cover the puncture with your thumb, remove the bandage from the arm above, and the bleeding will cease spontaneously ; the wound should be covered with a small com- press and a bandage ; the arm should be kept quiet three or four days, then the wound will be healed. Easy as this operation is in most cases, it still requires practice. Puncture with the lancet or scalpel is to be preferred to the spring-lancet; the latter was formerly very pop- ular, but is now very justly going out of fashion ; the spring-lancet is a so-called fleam, which is driven into the vein with a spring; we allow the instrument to operate, instead of doing it ourselves more certainly with the hand. Various obstacles may interfere with venesection. In very fat per- sons it is often difficult to see or feel the veins through the skin ; then besides compression we employ another means, that is holding the forearm in warm water, which increases the afflux of blood to this part of the body. Moreover, after opening the vein the fat may impede the escape of the blood by fat-lobules lying in the opening; these should be quickly snipped off with the scissors. Occasionally the flow of blood is mechanically obstructed by the arm being rotated or bent at a different angle after the puncture has been made, so that the open- ing in the vein no longer corresponds to that in the skin ; this is to be met by changing the position of the arm. There are other causes for the blood not flowing properly; such as the puncture being too small, a frequent fault with beginners ; the compression is too weak, this may be improved by tightening the bandage ; or, on the contrary, the com- pression is too great, so that the artery is also compressed, and little or no blood flows from the arm, this may be obviated by loosening the venesection bandage. Aids for increasing the flow of blood are : dip- ping the hand in warm water, and having the patient rhythmically open and close the hand, so that the blood may be forced out by the muscular contractions. We shall speak further on this point, as op- portunity offers, in the clinic. CHAPTER III. CONTUSIONS OF THE SOFT PABTS WITHOUT WOUJVDS. LECTURE XI. Causes of Contusions. — Nervous Concussion. — Subcutaneous Eupture of Vessels. — Rup- ture of Arteries. — Suggillations. — Ecchymoses. — Eeabsorption. — Termination in Fibrous Tumors, in Cysts, in Suppuration, and Putrefaction. — Treatment. By the action of a blunt object on the soft parts, the skin will sometimes be injured, sometimes it will not ; hence we distinguish con- tusions with or without wounds. We shall first consider the latter. These contusions are partly caused by the falling or striking of heavy objects on the body, partly by the body falling or striking against a hard, firm object. The immediate result of such a contusion is a crushing of the soft parts, which may be of any grade ; often we per- ceive scarcely any change, in other cases the parts are ground to a pulp. Whether the skin suffers solution of continuity by this application of force depends on various circumstances, especially on the form of the con- tusing body and the force of the blow, also on the nature of the parts un- der the skin ; for instance, the same force would cause contusion without a wound in a muscular thigh, that applied to the spine of the tibia would cause a wound, for in the latter case the sharp edge of bone would cut the skin from within outward. The elasticity and thickness of the skin also come into consideration ; these not only vary in different per- sons, but may differ in different parts of the body of the same indi- vidual. In contusion without wound we cannot immediately recognize the amount of destruction, but only indirectly from the state of the nerves and vessels, and also from the subsequent course. In contusion the first symptom in the nerves is pain, just as it is 142 CONTUSIONS OF THE SOFT PARTS WITHOUT WOUNDS. in wounds, but pain of a duller, more undefined character, although it may be very severe. In many cases, especially when he has struck against a hard body, the patient has a peculiar vibrating, threatening feeling in the injured part ; this feeling, which extends some distance beyond the seat of injury, is caused by the concussion of the nerves. For instance, if we strike the hand or finger quite hard, only a small part is actually contused, but not unfrequently there is concussion of the nerves of the whole hand, with great trembling, dull pain, on account of which the fingers cannot be moved, and there is almost complete loss of feeling for the moment. This condition passes off quickly, usually in a few seconds, and then a burning pain is felt in the contused part. The only explanation we have of this temporary symptom is that the nerve-substance of the axis cylinder suffers molecular displacement from the blow, which spontaneously passes off again. These symptoms of concussion (the commotion) do not by any means accompany all contusions ; they fail especially in cases where a heavy body comes against a limb at rest, but they are not unfrequently of great signifi- cance in contusions of the head ; here commotio cerebri is not unfre- quently united with contusio cerebri, or the former appears alone, for instance, in a fall on the feet or buttocks, whence the concussion is prop- agated to the brain and may induce very severe accidents or even death, without any preceptible anatomical changes. Concussion is es- sentially a change in the nervous system, hence we speak chiefly of cerebral or spinal concussion. But the peripheral nerves also may be concussed with the above symptoms ; but since in such cases the more localized contusion is especially prominent, this nervous state is per- haps too much neglected. Severe concussion of the thorax may in- duce the most dangerous symptoms simply from concussion of the cardiac and pulmonary nerves, whereby the circulation and respiration are disturbed, although for the most part only temporarily. Nor can a reflex action of the concussed nerve, especially of the sympathetic on the brain, be entirely denied. Doubtless some of you, when wrestling or boxing, have received a blow in the abdomen ; what terrible pain ! a feeling of faintness almost overcomes you for a time ; here we have an action on the brain and on the heart; one holds his breath and gathers his strength, to prevent sinking to the earth. Concussion of the ulnar nerve often occurs, when we strike the elbow hard ; most of you proba- bly know the heavy, dull pain, extending even to the little finger. Compression of sensitive nerves is said to cause contraction of the cerebral vessels, as is shown by recent experiments on rabbits ; possi- bly this explains the faintness from severe pain. All these are symptoms of concussion in the peripheral nerves. Now, as we do not know what specially takes place in the nerves, we CONTUSIONS OF NERVES AND VESSELS. 143 cannot judge whether these changes have any effect, and, if so, what, on the subsequent course of the contusion, and of the contused wound ; hence we cannot here study the nerves any further. Some unim- peachable observations seem to prove that this concussion of periph- eral nerves may induce motor and sensory paralysis, as well as atrophy of the muscles of a limb ; but the connection between cause and effect is often difficult to prove. Contusions of the nerves are distinguished from concussions by the fact that in them certain parts of the nerve-trunks, or their whole thickness, is destroyed, to the most varied extent and degree, by the force applied, so that we find them more or less pulpy. Under these circumstances, there must be a paralysis corresponding to the injury, from which we determine the nerve affected, and the extent of the effect. On the whole, such contusions of nerves without wounds are rare, for the chief nerve-trunks lie deep between the muscles, and so are less apt to be injured directly. It must a priori be acknowledged that concussion may affect other organs and tissues than nerves, and induce temporary or per- manent disturbances, not only of the functional but of the nutritive processes. Such disturbances may also have an important influence on the course of repair after the injury, and are mentioned by some surgeons as the chief causes of inflammations that are occasionally very violent and develop easily-decomposing exudations and infiltra- tions. I am far from denying the influence of an energetic concus- sion on a bone whose medulla and vessels are thereby torn, without its being fractured ; under some circumstances the results of such an injury might be more extensive and tedious than those of a fracture from too great bending; but we should not ascribe the frequent severity of the course of contused wounds entirely to this cause. Contusions of the vessels must be much more apparent, since the walls of the smaller vessels, especially of the subcutaneous veins, are destroyed by the contusing force, and blood escapes from them. Hence, subcutaneous hemorrhage is the almost constant consequence of a contusion. It would be much more considerable if in this variety of injury the wound of the vessel had sharp edges, and gaped ; but this is not usually the case. Contused wounds of the vessel are rough, uneven, ragged, and these irregularities form obstacles to the escape of the blood ; the friction is so great that the pressure of the blood is unable to overcome it ; fibrinous clots form on these inequal- ities, even extending into the calibre of the vessel, causing mechanical closure of the vessel, or thrombus. Contusion of the wall of a ves- sel, with alteration of its structure, may alone cause coagulation of the blood ; for Brueke has proved that a living, healthy intima of the 144 CONTUSIONS OF THE SOFT PARTS WITHOUT WOUNDS. vessel is very important for the fluidity of the blood within the vessel. We shall again return to this subject, under contused wounds. The counter-pressure of the soft parts prevents an excessive escape of blood, for the muscles and skin exercise a natural compression ; hence, these subcutaneous haemorrhages, even when from a large vessel of the extremities, are very seldom instantly dangerous to life. Of course, it is different in hasmorrhages into the cavities of the body ; here there is little besides movable parts, that can offer no sufficient opposition to the escape of the blood ; hence, these haemorrhages are not infrequently fatal. This may be in two ways : partly from the amount of blood escaping — into the thorax or abdomen, for instance — partly from the pressure of the blood on the parts in the cavity — on the brain, for instance — which are not only partly destroyed by the blood flowing from large vessels, but are compressed in various direc- tions, and their functions thus impaired. Hence, hasmorrhages in the brain cause rapidly-occurring paralyses, and often, also, disturbance of the sensorium. In the brain we call this escape of blood, as well as the symptoms induced by it, apoplexy (from airo and ixXt\go^ to knock down). If a large artery of an extremity be contused, the conditions are the same as in a stitched or compressed punctured wound. A traumatic aneurism, a pulsating tumor, forms, as described in the last lecture. But this is rare as compared with the numerous contusions occurring daily, and is so, doubtless, because the larger arteries lie quite deep, and the arterial coats are firm and elastic, so that they tear far less readily than the veins, although a short time since, in the clinic, we saw a subcutaneous rupture of the anterior tibial artery. A strong, muscular man had a fracture of the leg; the skin was uninjured; the tibia was fractured about the middle, the fibula rather higher. The considerable tumor that at once formed at the seat of fracture pulsated visibly and perceptibly to the touch on the anterior surface of the leg. There was very evident buzzing sound in it, which I was able to de- monstrate to the class. The foot was dressed with splints and band- ages ; we avoided the application of an immovable dressing, so that we might watch the further course of the traumatic aneurism that had evidently formed here. We renewed the dressing every three or four days, and could see the tumor gradually becoming smaller and pulsat- ing less strongly, till it finally disappeared, a fortnight after the injury. The aneurism had been cured by the compression from the bandage. Nor was the recovery of the fracture interrupted ; eight weeks after the injury, the patient had full use of his limb. The most frequent subcutaneous haemorrhages in contusions are from rupture of the subcutaneous veins. These effusions of blood CONTUSIONS OF BLOOD-VESSELS. 145 cause visible symptoms which vary, partly from the quantity of the effused blood, partly from the distribution of the blood in the tissue. The more vascular a part, and the more severely contused, the greater the extravasation. The extravasated blood, if it escapes from the vessels slowly, forms a passage-way between the connective-tissue bundles, especially those of the subcutaneous connective tissue and muscles ; this must cause infiltration of the tissue with blood and con- sequent swelling. These diffuse and subcutaneous haemorrhages we term suggillations or suffusions. The more relaxed and yielding, and the easier to press apart the tissue is, the more extensive will be the infiltration of blood, if it flows gradually but continually from the vessels for a time. Hence, as a rule, we find the effusions of blood in the eyelids and scrotum quite extensive, because the subcutaneous connective tissue there is so loose. The thinner the skin, the more readily and quickly we shall recognize the suggillation ; the blood has a blue color through the skin, or presses into it and gives it a steel- blue color. Under the conjunctiva bulbi, on the contrary, the blood appears quite red, as this membrane is so thin and transparent. Blood extravasations in the cutis itself appear as red spots (purpura) or striae (vibices) ; but in this form they are very rarely due to contu- sion, they are caused by spontaneous rupture of the vessels ; whether because the walls of the vessels are particularly thin in some persons, as in those already mentioned as being of hemorrhagic diathesis, or because they are especially brittle and tender from some unknown condition of the blood, as in scorbutis, some forms of typhus, morbus maculosus Werlhofii, etc. Contusion of the cutis may usually be rec- ognized by a very dark-blue color, passing into brown ; also by stria- tion of the epidermis with so-called chaps, or, as they are technically termed, excoriations, flaying of the skin. If much blood escape suddenly from the vessels and be effused in the loose cellular tissue, a more or less bounded cavity is formed. This form of effusion of blood is called ecckymosis, ecchymoma, hm- matoma, or blood-tumor. Whether the skin be discolored- at the same time, depends on how deep the blood lies under it. In deep effusions of blood, diffuse as well as circumscribed, we often find no discoloration of the skin, especially soon after the injury ; we only perceive a tumor whose rapid development immediately after an injury at once shows its nature ; this tumor feels soft and tense. The cir- cumscribed effusion of blood offers the very characteristic feeling of fluctuation. You may most readily obtain a clear idea of this feeling by filling a bladder with water and then feeling its walls. In surgical practice the recognition of fluctuation is very important, for there are innumerable cases where it is important to determine whether we 10 146 CONTUSIONS OF THE SOFT PARTS WITHOUT WOUNDS. * have to deal with a tumor of firm consistence, or with one containing fluid. You will be shown in the clinic how it is best to make this examination in different cases. Some of these effusions of blood have received particular names according to the localities where they occur. Thus those coming on the heads of the newly-born, between the various coverings of the skull and in it, are called cephalhematoma (from KeaXrj, head, and aLfiaroo), to soil with blood), cephalic tumors of the newly-born. The extravasations in the labia majora, from contusions or the spontaneous rupture of distended veins, have received the neat name of episiohmma- toma or episiorrhagia (from eireiatov, the external genitals). Effu- sions of blood in the pleura and pericardium have also special desig- nations : hmmatothorax, hcematopericardium, etc. On the whole, we attach little importance to these euphonic Latin and Greek names ; but you should know them, so as to understand them when reading medical books, and not seek for any thing mysterious behind them ; also that you may use them so as to express yourself quicker, and be readily understood. The subsequent course and symptoms are very characteristic of these subcutaneous effusions of blood. Looking first at the diffuse effusions of blood, immediately after the injury, we are rarely able, to decide how extensive the bleeding has been or still is. If you ex- amine the contused part the second or third day after the injury, you notice that the discoloration is more extensive than on the first day ; this appears to increase subsequently ; that is, it becomes more per- ceptible. The extent is sometimes astonishing. We once had in the clinic a man with fractured scapula ; at first there was only slight dis- coloration of the skin, although there was a large fluctuating tumor. On the eighth day, the whole back from the neck to the gluteal mus- cles was of a dark steel-blue, and presented a peculiar, almost comical appearance, the skin looking as if painted. Such widely-spreading extravasations are particularly apt to occur in cases of fractured bones, especially of the arm or leg. But fortunately this partly dark-blue, partly bluish-red color, along with which the skin is not sensitive and scarcely swollen, does not remain so, but further changes take place ; first there is further change of color, the blue and red pass into mixed brown, then to green, and finally to a bright lemon yellow. This pecu- liar play of colors has given rise to the expression of " beating one black and blue," or " giving one a black eye." The last color, the yellow, usually remains a long time, often for months ; it finally dis- appears, and no visible trace of the extravasation remains. If we ask ourselves whence come these various colorings of the skin, and if we have the opportunity of examining blood extravasa- CONTUSIONS OF BLOOD-VESSELS. 147 tions in various stages, we find that it is the coloring matter of the blood which gradually passes through the metamorphoses and shades of color. When the blood has escaped from the vessels and entered the connective tissue, the fibrine coagulates. The serum enters the connective tissue, and thence passes back into the vessels ; it is re- absorbed. The coloring matter of the blood leaves the blood-corpus- cles, and in a state of solution is distributed through the tissue. The fibrine and blood-corpuscles, for the most part, disintegrate to fine molecules, and in this state are reabsorbed by the vessels ; as in the thrombus a few white blood-cells may attain a higher development. The coloring matter of the blood which saturates the tissues passes through various, not thoroughly understood metamorphoses with change of color, till it is finally transformed into a permanent coloring matter, which is no longer soluble in the fluids of the body — hcematoidi?i. As in the thrombus, this is partly granular, partly crystalline ; in a pure state it is orange-colored, and Fig. 38. if scanty gives the tissue a yellow- ish color, if plentiful a deep orange hue. JReab.sorption of the extravasa- tion almost always takes place in diffuse suggillations, as the blood is very widely distributed through the tissues, and the vessels that have to accomplish the reabsorp- tion have not been affected by the 0r o°an'S , £&3$S&%£ a £& contusion ; it is the most desirable fied400, and under favorable circumstances the most frequent result after sub- cutaneous and intermuscular effusions of blood. The case is different in circumscribed effusions, in ecchymoses. Here the first question is as to the extent of the effusion, then about the state of the vessels surrounding it ; the more developed the latter, the less they have been injured by the contusion, the more hope there is of early reabsorption ; but its occurrence is always less constant in large effusions of this variety. There are various factors which inter- fere with it ; in the first place, there is thickening of the connective tissue around the effusion of blood, as around a foreign body (as in traumatic aneurism also), by which the blood is entirely encapsulated ; the fibrine of the effusion is deposited in layers on the inner surface of this sac, the fluid blood remains in the middle. Thus the vessels about the blood-tumor can take up very little fluid, as they are sepa- rated from the fluid part of the blood by layers of fibrine, which are 148 CONTUSIONS OF THE SOFT PARTS WITHOUT WOUNDS. often quite thick. Here we have the same conditions as in large fibrinous exudations in the pleura ; there also the fibrous deposits on the walls greatly interfere with reabsorption. This can only take place perfectly when the fibrine disintegrates to molecules, becomes fluid, and thus absorbable ; or when it is organized to connective tis- sue, and supplied with blood and lymph vessels. This is not so very rare in pleuritic deposits. But there is also another fate for such extrava- sations. The fluid portion of the blood may be completely reabsorbed, and a firm tumor composed of concentric, onion-like layers may remain. This results occasionally from extravasations in the labia majora; a so- called fibrous tumor is thus formed ; in the cavity of the uterus, also, such fibrous tumors occasionally develop. Some hcematomata may be partly organized to connective tissue, and gradually take up lime-salts and entirely calcify ; a rare termination, but one that occurs in effu- sions of blood in large goitres. Another mode is the transformation of the blood-tumor to a cyst ; this is seen in the brain, and in soft tumors. Besides other modes of origin, some cysts in goitres may owe their origin to such effusions. By a cyst or encysted tumor we mean sacs or bags containing more or less fluid. The contents of these cysts, resulting from extravasation of blood, are darker or lighter ac- cording to their age ; indeed, the blood-red may totally disappear from them, and the contents become quite clear or only slightly clouded by fat molecules. In large circumscribed extravasations you will find numerous and beautifully-formed hematoidin crystals more rarely than in small diffuse ones, for in the former fatty disintegration of the elements of the blood predominates, hence excretion of choles- terine crystals is more common in them. The capsule enclosing these old effusions arises partly from organization of the peripheral parts of the blood-clot, partly from the circumjacent tissue. Suppuration of circumscribed extravasations is far more frequent than the two last described metamorphoses, but is not so common as reabsorption. The inflammation in the vicinity, and the plastic pro- cess in the peripheral part of the extravasation, from which, in the two preceding cases, the thickened connective tissue was developed, which encapsulated the blood, assume a more acute character in the case we are about to speak of; a boundary layer is formed here also, but not slowly and gradually as in the preceding cases, but by rapid cell-formation ; plastic infiltration of the tissue does not lead to devel- opment of connective tissue, but to suppuration ; the inflammation after a time attacks the cutis, and it suppurates from within outward, and is finally perforated, and the pus mixed with blood is evacuated ; the walls of the cavity come together, cicatrize and grow together, and healing thus takes place. We shall speak more exactlv of this CONTUSIONS OF BLOOD-VESSELS. 149 mode of healing when treating of abscess; we call any pus-tumor, i. e., circumscribed collection of pus under the skin at any depth, an abscess : hence we term the above process the conversion of an ex- travasation of blood into an abscess. This process may be very pro- tracted, it may last three or four weeks, but, if not dangerous from its location, it generally runs a favorable course. We recognize the sup- puration of an extravasation of blood by the increasing inflammatory redness of the skin, the growth of the tumor, increasing pain, occasion- ally accompanied by fever, and finally by thinning of the skin at some point, where it is finally perforated. Lastly, there may be rapid decomposition of the extravasation ; fortunately, this is rare. Then the tumor grows hot, tense, and very painful, the fever usually becomes considerable, chills and other severe general symptoms may occur. This termination is the worst, and the only one that requires speedy relief. Whether there shall be reabsorption, suppuration, or putrefaction of an extravasation, depends not only on the amount of the effused blood, but very much on the grade of the contusion that the tissues have suffered ; as long as these may return to their normal state, re- absorption will be probable ; if the tissues be broken down and pass into disintegration or decomposition, they will induce suppuration 01 decomposition of the blood ; briefly, the effused blood will have the same fate as the contused tissue. While the skin is uninjured we cannot judge accurately how much the muscles, tendons, and fasciae, are injured ; occasionally the size of the extravasation may give some aid on this point, but it is a very uncertain measure ; it is better to test the amount of functional ac- tivity of the affected muscles, but even the results thus given must be carefully accepted ; the amount of force that has acted on the part may lead to an approximate estimation of the existing subcutaneous destruction. In contusion of muscles, as in wounds, healing takes place from the crushed muscular elements undergoing molecular disin- tegration and being absorbed, or by being eliminated with the pus on suppuration of the extravasation, but then there is new formation both of connective tissue and muscle. The largest extravasations, either diffuse or circumscribed, are usually accompanied by injuries of the bones ; but it will be better to consider the injury of the bone in a separate section. If a portion of the body be so crushed as to be entirely or mostly incapable of living, it becomes cold, bluish red, brownish red, then black ; it begins to putrefy ; the products of putrefaction enter the neighboring tissues and the blood ; the local inflammations, as well as the fever, assume peculiar forms. As this is the same in contusions with or without wounds, we shall speak of it later. 150 CONTUSIONS OF THE SOFT PARTS WITHOUT WOUNDS. The treatment of contusions without wound has for its object the conduction of the process to the most favorable termination possible, that is, to reabsorption of the extravasation ; when this takes place, the injuries to the other soft parts also progress favorably, as the whole process remains subcutaneous. We here refer solely to those cases where the contusion of the soft parts and the extravasation are the only objects of treatment; where the bone is broken it should be treated first of all, the extravasation of itself would scarcely be an ob- ject for special treatment. If called to a contusion that has just oc- curred, the indication may be to arrest any still continuing haemor- rhage ; this is best done by compression, which, where convenient, is to be made by evenly-applied bandages. In North Germany, when a child falls on its head, or knocks its forehead, the mother or nurse at once presses the handle of a spoon on the injured spot to prevent the formation of a blood-bruise. This is a very suitable popular remedy ; by the instantaneous compression the further escape of blood is hin- dered, as is also its collection at one point, because it is compelled by the pressure to distribute itself in the surrounding tissue ; an ecchy- mosis just forming may thus be transformed into a suggillation, so that the blood may more readily be absorbed. You may occasionally at- tain the same object by a well-applied bandage. But we rarely see the injury so early, and in the great majority of cases there is also an injury of a bone or joint, and the treatment of the blood-extravasation is a secondary object. The use of cold, in the shape of bladders or rubber bags filled with ice, or of cold lotions, to which it is an old custom to add vinegar or lead-water, is resorted to as a remedy in recent contusions; it is said to prevent excessive inflammation. But you must not rely too much on these remedies ; the means that most aids the reabsorption of blood extravasations is regular compression and rest of the part. Hence it is best to envelop the extremities in moist bandages, and over them apply wet cloths, which are to be renewed every three or four hours. Other remedies, which usually act well in inflammations of the skin, such as mercurial ointment, are of little use here. But I must not forget arnica ; this remedy is so honored by some families and physicians that they would consider it unpardonable to neglect prescribing lotions of infusion of arnica, or of water with the addition of tincture of arnica. Faith is mighty; one believes in arnica, an- other in lead- water, a third in vinegar, as the potent external reab- sorbent. In all cases the effect is doubtless simply due to the moist- ure and the variation of temperature of the skin caused by the com- press, whereby the capillaries are kept active, now brought to contrac- tion, now to dilatation, and thus placed in a better state for reabsorp- tion because thev are active. TREATMENT OF BLOOD-EXTRAVASATIONS. 151 Diffuse blood-extravasations of the skin with moderate contusion of the soft parts are usually absorbed without much treatment. If a circumscribed extravasation does not change considerably in the course of a fortnight, there is nevertheless no indication for further interfer- ence. We then paint the swelling once or twice daily with dilute tincture of iodine, compress it with a suitable bandage, and not unfre- quently see the swelling gradually subside after several weeks. Should it become hot, and the skin over it grow red and painful, we must expect suppuration ; then even the continued application of cold will rarely change the course, though it may alleviate it. Then, in order to hasten the termination of the suppuration, which cannot be avoided, we may apply warm fomentations, either simply of folded muslin wet with warm water or cataplasms ; now you quietly await the further course ; if the general health be not impaired, but the pa- tient feels pretty well, you calmly await perforation ; it will perhaps be weeks before the skin gradually becomes thinner at some point and finally opens, the pus is evacuated, the walls of the large cavity fall together, and in a short time the parts are all healed. At the commencement of this lecture I mentioned a case where, with a frac- tured scapula, there was an enormous partly diffuse, partly circum- scribed extravasation ; here there was a strongly-fluctuating tumor, which was not reabsorbed, while the diffuse effusion was rapidly re- moved ; the suppuration did not end in perforation till the fifth week, then one and a half to two quarts of pus were evacuated ; a week later this enormous cavity was healed, and the patient left the hospi- tal well. Why we do not here interfere earlier and aid Nature by an incision, we shall consider more closely when we treat of abscesses. * Should the tension of the swelling rapidly increase, however, dur- ing the suppuration of the extravasation, and high fever with chills occur, we may suppose that the blood and pus are decomposing, that there is putrefaction of the enclosed fluid. Fortunately, this is rare, and occurs almost exclusively where there is great crushing of the muscles or splintering of the bone. With such symptoms of course the putrid fluid should be quickly evacuated ; then you should make a large incision through the skin, unless this be forbidden by the ana- tomical position of the parts ; in which case several small incisions should be made at points where the fluid may escape freely and easily. These incisions greatly alter the aspect of the case ; you have changed the subcutaneous contusion to an open contused wound. Now other conditions come into play, which we shall treat of in the next lecture. We must still mention that, if extensive putrefaction of the soft parts follows such contusions, amputation is indicated, although this unfortu- nate case rarely happens without coincident fracture of the bones. CHAPTER IV. CONTUSED AND LACERATED WOUNDS OF THE SOFT PARTS. LECTURE XII. Mode of Occurrence of these Wounds ; their Appearance. — Slight Haemorrhage in Con- tused Wounds. — Early Secondary Haemorrhages. — Gangrene of the Edges of the Wound. — Influences that effect the Slower or more Eapid Detachment of the Dead Tissue. — Indications for Primary Amputation. — Local Complications in Contused Wounds ; Decomposition, Putrefaction, Septic Inflammations. — Contusion of Ar- teries ; Late Secondary Haemorrhages. The causes of contused wounds, of which we have to treat to-day, are the same as those of simple contusions, only in the first cases the force is usually greater than in the latter, or the body by which they are induced is of such a form as to divide the skin and soft parts easily, or else parts of the body have been injured where the skin is particularly thin, or lies over parts unusually firm. The kick of a horse, blow from a stick, bite of an animal or a man, being run over, wounding with blunt knives, saws, etc., are frequent causes of contused wounds. Nothing, however, causes more contused wounds than rapidly-moving wheels and rollers of machinery, cutting- machines, circular-saws, spinning-jennies, and the various machines with cog-wheels and hooks. All of these instruments, the product of advancing industry, do much injury among the operatives. Men and women, adults and children, with crushed fingers, mashed hands, ragged, lacerated wounds of the forearm and arm, are now among the constant patients in the surgical wards of hospitals in every large city. Innumerable persons are thus maimed of fingers, hands, or arms, and many of these patients die as a result of their injuries. If to these you add (what recently is becoming rarer, it is true) railroad injuries, those caused by blasting, building tunnels, etc., you may APPEARANCE OF CONTUSED WOUNDS. 153 imagine, not only how much sweat, but how much blood, clings to the many evidences of modern culture. At the same time it is not to be denied that the chief cause of these accidents is the carelessness, often the foolhardiness, of the workman. Familiarity with the dan- gerous object renders persons at last careless and rash ; some pay for this with their lives. Gunshot wounds also essentially belong to contused wounds ; but, as they have some peculiarities of their own, we shall treat of them in a special chapter. Lacerated wounds, and tearing out of pieces from the limbs, we shall consider at the end of this chapter. Fractures of bones of the most varied and dangerous varieties ac- company contused wounds from all the above causes ; but for the present we shall leave these out of consideration, and treat only of the soft parts. In most cases, the appearance of a wound indicates whether it was due to incision or contusion. You already know the character of in- cised wounds, and I have alluded to some cases where a contused wound had the appearance of an incised one, and the reverse. Con- tused wounds, like incised, may be accompanied by loss of substance, or there may be simply solution of continuity. The borders of these wounds are generally uneven, especially the edges of the skin ; the muscles occasionally look as if chopped ; tags of the soft parts, of various sizes, not unfrequently large flaps, hang in the wound, and may have a bluish-red color, from the blood stagnated or effused in them. Tendons are torn or pulled out, fasciae are torn, the skin, for some distance around the wound, is not unfrequently detached from the fascia, especially if the contusing force was combined with a tear- ing and twisting. The grade of this destruction of the soft parts of course varies greatly, and its extent cannot always be accurately de- termined, as we cannot always see how far the contusion and tearing extend beyond the wound ; from the subsequent course of the wound we often satisfy ourselves that the contusion extended much further than the size of the wound indicated ; that separation of muscles, di- visions of fasciae, and effusions of blood, extended under the skin, which may have been but little torn. It is unfortunate that the skin- wound gives no means of judging of the extent and depth of the con- tusion, for it renders it very difficult to correctly estimate such an in- jury at the first examination; while the appearance of the wound gives the laity no idea of danger, the experienced surgeon soon sees the gravity of the case. Since the injury, especially when due to machinery, is very rapidly done, the pain is not great ; and immediately after the injury the pain from contused wounds is often very slight ; the more so, the greater 154 CONTUSED AND LACERATED WOUNDS OF THE SOFT PARTS. the injury and crushing of the parts. This is readily explained by the nerves in the wound being entirely mashed and destroyed, conse- quently incapable of conducting ; moreover, what I told you in the last lecture about local concussion of nerves, the so-called stupor of the injured part, comes into play. At first sight it seems rather remarkable that these contused wounds bleed little, if any, even if large veins or arteries be crushed or torn. There are well-observed cases to show that, after complete crushing of the femoral or axillary artery, there was absolutely no primary haemorrhage. It is true, this is rare ; in many cases where there is complete solution of continuity of a large artery by a contusion, although there is no spirting stream, there is constant trickling of blood ; this, coming from the femoral artery, would speedily cause death. I have already told you how this arrest of haemorrhage takes place in small arteries, but will make it clearer to you by an illustra- tion. A railroad hand was run over by a locomotive, so that the wheel passed over his left thigh just below the hip-joint. The unfor- tunate was at once brought on a litter to the hospital ; meantime he had lost much blood, and came in very pale and anaemic, but perfectly conscious. After complete removal of the torn clothing, we found a horrible mangling of the skin and muscles. The bone was crushed to atoms, the muscles were partly mashed to pulp, partly hung in tags from the wound, the skin was torn up as far as the hip-joint. At no point of this horrible wound did an artery spirt, but from the depth con- siderable blood constantly trickled out, and the general state of the pa- tient clearly showed that he had already lost much blood. It was evident that the only thing to be done here was to amputate at the hip-joint, but in the condition the patient then was, this was not to be thought of; the new loss of blood from this severe operation would undoubt- edly have been at once fatal. Hence it was, first of all, necessary to arrest the haemorrhage, which evidently came from a rupture of the femoral artery. I first tried to find the femoral in the wound, while it was compressed above ; but all the muscles were so displaced, all the anatomical relations were so changed, that this was not quickly done, hence I proceeded to ligate the artery below Poupart's ligament. After this was done, most of the bleeding ceased, but not entirely, on account of the free arterial anastomosis ; and as no regular dressing could be applied, on account of the existing mangling, I surrounded the limb firmly with a tourniquet, close below where I proposed to exarticulate. Now the bleeding stopped; we gave various remedies to revivify the patient ; wine, warm drinks, etc., were ad- ministered, so that, toward evening, he had so far recovered that his temperature was again normal, and the radial pulse was again good. HEMORRHAGE FROM CONTUSED WOUNDS. 155 I should have preferred postponing the operation till the following day, if, in spite of ligature and tourniquet, with the strengthening of the heart's beat, there had not been some bleeding from the wound, so that I feared the patient might bleed to death during the night. Hence, with the able help of my assistants, I exarticulated the thigh as rapidly as possible. During the operation the absolute loss of blood was not great, but it was too much for the already-debilitated patient. At first all seemed to go well ; the spirting vessels were all ligated, the wound cleansed, and the patient placed in bed ; soon he suffered from restlessness and dyspnoea, which increased, finally con- vulsions occurred, and the patient expired two hours after the opera- tion. Examination of the femoral artery of the crushed extremity showed the following : In the upper third of the thigh there was a crushed and torn part, comprising about one-third the calibre of the artery. The tags of the tunica intima, as well as the other coats of vessel, and the connective tissue of the sheath, had rolled up into the calibre of the artery, and the blood could only escape slowly ; the surrounding tissue was completely saturated with blood. In this case, no clot had formed in the artery, as the escape of blood was still too free to permit this ; but, if you imagine that the contusion had affected the entire circumference of the artery, you may understand how the tags of the coats of the vessel pressing into its calibre from all sides might have rendered the escape of the blood more difficult, or even impossible ; then a thrombus would have formed, and stopped the vessel, and gradually have become organized, so as to cause permanent closure, just as after ligation. If no haemorrhage had followed the partial crushing of the artery in this case, if, for instance, the crushing had occurred without an external wound, possibly a clot would simply have formed at the part roughened by the contusion, a thrombus forming from the wall ; in this case there might have been crushing of the artery with preservation of its calibre, a result that is said to have been observed. If you apply the above-described condition of a large crushed ar- tery to smaller arteries, you will understand how there may here more readily be complete spontaneous plugging of the calibre of the vessels partly by in-rolling of the fragile, torn tunica intima, partly by con* traction of the tunica muscularis and by the tags of the adventitia, and that consequently bleeding may fail almost entirely in such con- tused wounds. Observation of this led a French surgeon, Chassaignac, to invent an instrument for crushing off portions of the body ; he terms this operation ecrasement, the instrument he calls an 'ecraseur. It con- sists of a strong metallic ligature, composed of small links, which 156 CONTUSED AND LACERATED WOUNDS OF THE SOFT PARTS. is to be applied around the part to be removed, and then drawn slow- ly into a strong metal frame by means of a ratch arrangement. When the instrument is properly used it causes absolutely no haemor- rhage. Little favor as the instrument at first found among surgeons, from their dislike to contused wounds in operative surgery, there is no doubt of its advantages in suitable cases. Wounds caused by ecrasement usually heal with very little local or general reaction ; co- incident inflammations occur less frequently with this class of wounds than with pure incised wounds. Nevertheless ecrasement will always be limited to a small number of operations. There is another factor for limiting the haemorrhages in extensive contusions, that is, the weakening of the heart's action caused by the injury, probably due to reflex action. Persons badly injured, besides suffering from loss of blood and injury of the nerve-centres, are usually for a time in a state of numbness or stupor ; the word most commonly used to express this state of depression is " shock." The fright from the injury and all thoughts about it, which follow in rapid succession, unite in producing great psychical depression, which has a paralyzing effect on the heart's action. Still, even in persons not greatly af- fected psychically by the injury, as old soldiers who have often been wounded, or very phlegmatic persons, a severe injury is not entirely without this effect, so that we must suppose that there are purely physical causes for shock. Contusions of the abdomen have an even more depressing effect on the nerve-centres than do those of the ex- tremities, as I have already told you. In this connection the so-called beating-experiment (Klopfversuch) of Goh is very interesting: if we repeatedly strike a frog sharply on the belly with the handle of a scalpel, he becomes as it were paralytic ; as a result of paresis of their walls, the abdominal vessels distend greatly and take up almost all the blood, so that all the other vessels and even the heart become blood- less, and the latter only contracts feebly. When the patient has recovered from this state of psychical and physical depression, the heart begins to act with its former or even greater energj', then haemorrhages may occur from vessels that had not previously bled. This variety of secondary haemorrhage occurs after operations, when the effect of the anaesthetic has passed off. Hence the patient should be carefully watched at this time, to guard against such secondary haemorrhages, especially if, from the locality of the in- jury, there be reason to suspect that a large artery has been injured. Now we must again examine somewhat more attentively the local changes in the wound. Although doubtless the processes that take place in the contused wound, the changes on its surface and final healing, must be essentially the same as in incised wounds, still in the appearances in the two cases HEALING OF CONTUSED WOUNDS. 157 there are considerable differences. One very important circumstance is, that in contused wounds the nutrition of the edges of the skin and soft parts is more or less extensively destroyed or impaired, or, to ex- press this more anatomically, the circulation and nerve influence in the borders of contused wounds are more or less lost. This at once pre- vents the possibility of healing by first intention, as this requires per- fect vitality in the surfaces of the wound. Hence contused wounds always heal with suppuration. This observation causes us to introduce sutures or try firm union by plasters very rarely ; you may consider this as a general rule. There are exceptions to this rule, which you will only learn exactly in the clinic, and of which I shall only incidentally remark, that occasionally we fasten large, loose flaps of skin in their original position, not be- cause we expect them to unite by first intention, but that they may not from the first retract ±00 much and atrophy to too great an ex- tent. Granulation and suppuration are esentially the same as in wounds with loss of substance, except that they are slower, and we might say more uncertain at many places. In incised wounds with loss of sub- stance also a thin superficial layer of tissue is occasionally lost, if it be not very well nourished ; but this is insignificant as compared with the extensive loss of tissue-shreds that occurs in contused wounds. Many days, often for weeks, tags of dead (necrosed) skin, fascia, and tendons, hang to the edges of the wounds, while other parts are luxuriantly granulating. This process of detachment of the dead from the living tissue takes place as follows : A cell infiltration and formation of vessels, lead- ing to development of granulations, start from the borders of the new tissue ; granulations form on the border of the healthy tissue, and their surface breaks down into pus. With this change to the fluid state as it were the solution and melting of the tissue, of course the cohe- sion of the parts must cease, and the dead shreds, which previously were in continuity with the living tissue by their filamentary connec- tion, must now fall. Hence part of the surface of contused wounds almost always be- comes necrosed (from veitpog, dead), gangrenous (from r\ yayypcuva from ypaivo), I consume), which are both expressions for parts in which circulation and innervation have ceased, or which are entirely dead. The part where the detachment takes place is technically called the line of demarcation of the gangrene. These technical terms, which refer to every variety of gangrene, no matter how it occurs, you must only notice provisionally here. I will try to render this process of detachment of necrosed tissue by suppuration more distinct by means of a diagram. 158 CONTUSED AND LACERATED WOUNDS OF THE SOFT PARTS. In the portion of connective tissue represented, suppose c, the border of the wound, be so destroyed by the injury that its circulation is arrested and it is no longer nourished ; the blood is coagulated in the vessels as far as the shading extends in the diagram. Now cell- infiltration and inflammatory new formation begin at the outer edge of the living tissue, at the border between a and b where the vessels termi- nate in loops ; these vascular loops dilate, grow, and multiply ; in the tissue the infiltration is constantly increased by wandering cells, as if the edge of the wound were here ; granulation tissue is formed ; this turns to pus, on the surface, that is, close to the dead tissue, and then of course the necrosed part falls, because its cohesion with the living tissue has ceased. Hence detachment of the necrosed shreds of tissue results from inflammation with suppuration ; when the dead por- tion of tissue has fallen, the subjacent, suppurating layer of granula- tions comes to light, having been already developed before the detachment of the necrosed part. What you here see in connective tissue is true of the other tissues, bone not excepted. Diagram of the process of detachment of dead connective tissue in contused wounds. Magni- fied 300 diameters ; a, crushed necrosed part ; b, living tissue ; c, surface of the wound. HEALING OF CONTUSED WOUNDS. 15 g In many cases, on the fresh borders of the wound we may see about how much will die, but by no means in all cases, and we can never decide from the first as to the bordering line of the dead tissue. Completely crushed skin usually has a dark-blue violet appearance and feels cold; in other cases we at first see no change in it, but in a few days it is white, without sensation, later it becomes gray, or, when quite dry, grayish or brownish black. These various colors depend chiefly on the amount of coagulated blood remaining in the vessels or infiltrated in the tissue itself by the partial rupture of the vessels. The healthy skin is bordered by a rose-red line which loses itself in a diffuse redness ; this is due to collateral dilatation of the capillaries, and is partly also a symptom of fluxion, of which we have before spoken ; it is the reaction redness about the wound, which we have already described ; for the living wound-surface only begins where the blood still flows through the capillaries. In muscles, fascias, and tendons, we can decide far less frequently, and often not at all, from the appearance at first, how far they will be detached. The time required for the dead tissue to be separated and detached from the living varies greatly with the different tissues. This de- pends first on the vascularity of the tissues ; the richer a tissue in capillaries, the softer it is, the more readily cells spread in it, and the richer it is by nature in cells capable of development, so much the more rapidly will the formation of granulations and the detachment of the necrosed parts come about. All these circumstances combine best in the subcutaneous cellular tissue and in the muscles, least so in tendons and fascise ; the cutis stands in the middle in this respect. The circumstances are the most unfavorable for the bones ; conse- quently the separation of the dead from the living takes place most slowly. Of this more hereafter. Rich supply of nerves seems to have little effect in this process. But there are many other influences that hinder the detachment of the dead parts, or, what is the same thing, that retard the forma- tion of granulations and pus ; such as continued action of cold on the wound, as might be effected by applications of bladders of ice. The cold keeps the vessels contracted. The cell-movements, the escape of cells from the vessels, go on very slowly under the influence of low temperature. Treatment by continued warmth, as by the application of cataplasms, has the opposite effect ; by this means we increase the fluxion to the capillaries and cause them to dilate, as you may readily see from the redness you induce on the healthy skin by application of a hot cataplasm ; it is known that the high temperature also hastens the cell-activity. 160 CONTUSED AND LACERATED WOUNDS OF THE SOFT PARTS. It is entirely impossible to tell beforehand the influence of the general state of the patient on this local process. It is true we may say in general terms that it is energetic in the strong, stout, and young, more moderate and sluggish in weak persons ; but on this point we are often deceived. From what has already been said you may suppose that contused wounds need much longer to heal than more simple incised ones. It will also be evident that there may be circumstances under which amputation of the limb will be necessary, all the soft parts being en- tirely mashed and torn. There are cases where the soft parts are so torn from the bone that this alone remains ; so that on the one hand cicatrization cannot occur, and on the other, if the extremity did heal in months or years, it would be perfectly useless, and hence it would be better to remove it at once. Still, even the simple complete detach- ment of the skin from the greater part of an extremity may some- times, though rarely, render amputation necessary, as in the case of a girl who lost the skin from the wrist to the ends of her fingers be- tween the rollers of a spinning machine. Fortunately such cases are not frequent; in similar injuries of sin- gle fingers we mostly leave the detachment to nature, so that no more is lost than is absolutely incapable of living ; for we should always, remember in maiming of the hand that every line, more or less, is of importance, that especially single fingers, and particularly the thumb, should be preserved whenever possible, for such fingers, if only slightly capable of performing their functions, are more useful than the best- made artificial hand ; for the foot and lower extremity there are other considerations, of which we shall hereafter speak when we come to complicated fractures of bones. Would that this maiming and slow healing, bad as they are, were the only cares we had with our patients having contused wounds ! Unfortunately there is a whole series of local and general complica- tions which directly or indirectly endanger life. We shall first speak of the chief local complications ; for the more general, the " accidental diseases in wounds," we reserve a future chapter. Considerable danger may arise from the decomposing tissue on the wound infecting the healthy parts. Putrid matters act as fer- ments on other organic combinations, especially on fluids containing them; they induce progressive decomposition. We might wonder that such extensive decomposition of the part which is injured, if not killed, should not occur more frequently than it actually does. But in most cases cell-action occurs so quickly on the border of the living tissue that a sort of living wall is formed ; this new formation does not read- ily permit the passage of putrid matter, and the granulation surface, HEALING OF CONTUSED WOUNDS. 161 if once formed, is particularly resistant to such influences. In many places it is a popular remedy to cover ulcers with cow-dung and other dirty things; this never causes extensive putrefactions on granulating wounds. But if you apply such substances to fresh wounds, and bind them firmly on so that the tissue may be mechanically impregnated with putrid matter, they will usually become gangrenous to a certain depth, and then an energetic cell-formation opposes the putrefaction. The reason why decomposing matters act so injuriously on fresh wounds, and so slightly on granulating ones, I consider to be, that they are chiefly absorbed by the lymphatic vessels. If you inject a drachm of putrid fluid into the subcutaneous cellular tissue of a dog, the result will be inflammation, fever, and septicaemia. If you make a large granulating surface on a dog, and dress it daily with charpie soaked in putrid fluid, it will have no decided effect. Certain dis- solved putrid matters may pass through the walls of the veins and capillaries ; but surgical experience teaches that lymphangitis ac- companies poisoned wounds much oftener than phlebitis does. The more the tissue is saturated with fluid, the more it is disposed to decomposition. Hence, the cases where great cedematous swell- ing occurs after contusions are the most dangerous in this respect ; but this oedema comes on very readily as the venous circulation is obstructed, from extensive rupture and crushing of the vessels, which indeed often extend far beyond the borders of the wound. Imagine a forearm caught under a stone weighing several hun- dred-weight ; there will probably be only a small skin-wound, but extensive crushing of the muscles, tendons, and fasciae of the forearm, and mashing and rupture of most of the veins ; great cedematous swelling will speedily result, as the blood from the arteries is driven with greater energy into the capillaries, and cannot escape by its cus- tomary passage through the veins, and hence, under the increased pressure, the serum escapes through the capillary walls into the tissue in greater amount. What a tumult in the circulation and in the whole nutrition ! It must soon appear where the blood can still cir- culate, and where not. In the wound, at first, under the influence of the air, decomposition of the parts incapable of living begins ; this advances to the stagnating fluids, and, in unfortunate cases, it con- stantly progresses ; the whole extremity swells terribly as far as the shoulder ; the skin becomes bright red, tense, painful, covered with vesicles, from the escape of serum from the cutaneous capillaries under the epidermis. These symptoms usually appear with alarming rapidity the third day after the injury. As a result of this disturb- ance of circulation, the whole extremity may become gangrenous; in other cases, only the fasciae, tendons, and some shreds of skin die. 11 162 CONTUSED AND LACERATED WOUNDS OF THE SOFT PARTS. There is cell-infiltration of all the connective tissue of the extremity (of the subcutaneous cellular tissue, the perimysium, neurilemma, sheaths of the vessels, periosteum, etc.), which leads to suppuration. Toward the sixth or eighth day the whole extremity may be entirely saturated with pus and putrid fluid. Theoretically, we might imagine such cases curable ; that is, we might imagine that, by making suit- able openings in the skin, the pus and dead tissue might be evacu- ated. But this rarely occurs in practice. If the case has undergone the above distention, generally only quick amputation can save the patient, and even this is not always successful. We may term this variety of infiltration sanio-serous. There is a cellular-tissue inflam- mation, caused by local septic infection ; a septic phlegmon, whose products again have great tendency to decomposition, but which finally leads to extensive suppuration and necrosis of tissue if the patient lives through the blood-infection which always accompanies it. The earlier such processes limit themselves, the better the prognosis ; with the advance of the local symptoms the danger of death of the patient increases. With the detachment of dead portions of tissue, we must again return to the arteries. An artery may be contused, so as not to be fully divided, and the blood continues to flow through it although part of its wall is incapable of living, and becomes detached on the sixth to the ninth day, or even later. As soon as this occurs, there will be a haemorrhage in proportion to the size of the artery. These late secondary haemorrhages, which usually come on suddenly, are exceed- ingly dangerous, as they attack the patient unexpectedly, sometimes while sleeping, and frequently remain unnoticed until much blood has escaped. Besides the above manner, late arterial secondary haemor- rhage may also result from suppuration of the thrombus, or of the wall of the artery. I observed a case of this kind late in the third week after a severe operation in the immediate vicinity of the femoral artery, in which, however, the artery was not wounded. The bleeding began at night ; as the wound looked perfectly well, and the patient had for some time slept the whole night, and for some days had been promised permission to get up the next day, there was no nurse in his private room. He woke in the middle of the night (the twenty-second day after the operation), found himself swimming in blood, and rung at once for the nurse. She instantly called the assist- ant physician of the ward, who found the patient unconscious. He at once compressed the artery in the wound, and, while I was being called, every thing was done to restore the patient. I found him pulseless, unconscious, but breathing, and the heart still beating. SECONDARY HAEMORRHAGE. 163 While I made ready to ligate the femoral artery, the patient died he had bled to death. A very sad case ! A man otherwise healthy, strong, in the bloom of life, near recovery, must end his life in this miserable way ! Rarely has a case so depressed me. Still there was no blame anywhere, as it happened all the circumstances had been very favorable. The nurse was awake in the next room, the physician was only down one flight of stairs in the same house, and was with the patient in three or four minutes ; but the bleeding must have existed before he woke. He was probably awakened by the feeling of wet- ness in the bed. On autopsy, a small spot of the femoral artery was found suppurated and perforated. Fortunately, it is not always a femoral that bleeds, nor does the bleeding always come so precipi- tately, or at night ; hence, we should not become dissatisfied with our art from such a rare case. Usually such arterial haemorrhages from suppurating wounds are at first insignificant, and soon cease under styptics or compression ; but after a few days the bleeding comes on more actively, and is more difficult to arrest ; finally, the haemorrhages recur more and more quickly, and the patient constantly becomes worse. In all severe arterial haemorrhage instantaneous compression is the first remedy. Every nurse should understand compressing the arterial trunks of the extremities ; but they soon lose their presence of mind, as in the above case, and, in their first terror, run themselves for the surgeon, instead of compressing the vessel and sending some one else. Compression is only a palliative remedy. The bleeding may cease after it ; but, if it be considerable, and you are sure of its origin, I strongly advise you at once to ligate the artery at the point of election, for this is the only certain remedy. You should do this the sooner if the patient be already exhausted ; remember that a sec- ond or third such bleeding will surely cause death. Hence, in the operative course, you should particularly practise ligating the arteries, so that you may find them so certainly that you could operate when half asleep. In these particular cases much time is unnecessarily lost in applying styptics, which usually act only palliatively, or not at all. Ligation of arteries is only a trifle for one who knows anatomy thor- oughly, and has employed his time well in the operative courses. Anatomy, gentlemen I Anatomy, and again anatomy ! A human ife often hangs on the certainty of your knowledge in this branch. While treating of secondary haemorrhages, we shall speak of parenchymatous liaimw^rliages. The blood rises from the granula- tions as from a sponge ; we nowhere see a bleeding, spirting vessel. The whole surface bleeds, especially at every change of the dressing. This may be due to various causes : great friability or destructibility of the granulations, that is, their defective organization, may be the fault, 164 CONTUSED AND LACERATED WOUNDS OF THE SOFT PAETS. and this malorganization of the granulations again may depend on con- stitutional diseases (hsemorrhagic diathesis, scorbutis, septic or pyaemic infection). Still, local causes about the wound are imaginable, as, if extensive coagulation gradually formed in the surrounding veins, the circulation in the vessels of the granulations would be so affected ; the pressure of blood would so increase that not only the serum might escape from them, but they would rupture. It is true I have hitherto had no opportunity of confirming this by autopsy, but I have seen very few of these parenchymatous haemorrhages. The latter explanation sounds very plausible ; so far as I know, it originates with Stromeyer. He calls such haemorrhages " haemostatic." According to the causes, it may be more or less difficult to arrest such haemorrhages ; in most cases ice, compression, and styptics, will be proper, or, in severe cases, ligation of the arterial trunk, although this occasionally fails. This form of haemorrhage occurs chiefly in very debilitated persons, who have been exhausted by suppuration and fever, and hence has a bad significance for the general state of the patient. LECTURE XIII. Progressive Suppuration starting from Contused Wounds. — Secondary Inflammations of the Wound: their Causes; Local Infection. — Febrile Eeaction in Contused Wounds : Secondary Fever ; Suppurative Fever ; Chill ; their Causes. — Treatment of Contused Wounds : Immersion, Ice-bladders, Irrigation ; Criticism of these Methods. — Incisions. — Counter-openings. — Drainage. — Cataplasms. — Open Treat- ment of Wounds ; Lister's Dressing. — Prophylaxis against Secondary Inflamma- tions. — Internal Treatment of those severely Wounded : Quinine ; Opium. — Lacerated Wounds : Subcutaneous Eupture of Muscles and Tendons; Tearing out of Muscles and Tendons; Tearing out of Pieces of a Limb. The granulating surface that develops on a contused wound is generally very irregular, and often has numerous angles and pockets ; there is suppuration not only of the surface of the wound, but of the surrounding contused parts under the uninjured skin ; hence the neighboring skin often appears undermined by pus. The inflamma- tion and suppuration often unexpectedly extend between the muscles, along the bones, and in the sheaths of the tendons, because these parts were also affected by the injury. The process of inflammation, once excited, creeps along, especially in the sheaths of the tendons and in the cellular tissue ; new collections of pus form, superficially or in the depths ; the injured part remains swollen and cedematous ; on the surface the granulations are smeary, yellow, swollen, and spongy. When we press in the vicinity of the wound, the pus flows INFLAMMATION OF CONTUSED WOUNDS. 165 slowly from smaller or larger openings, which have formed sponta- neously, and this pus which has remained for a time in the depth is not infrequently thin and bad smelling. Should the process con- tinue long, the patient becomes more miserable and weak ; he has high and continued fever. A wound, which perhaps at first appeared insignificant, perhaps about the hand, has extended horribly, and in- duced severe general disturbance. The sheaths of the tendons about the hands and feet are particularly favorable for the extension of deep suppurations, which readily attack the joints, while, on the other hand, articular inflammations of the extremities readily attack the sheaths of the tendons. These states may take a very dangerous turn, and you should be constantly on your guard. From the constant pu- rulent infection, as well as from the daily loss of pus, even the strong- est man may emaciate in a few weeks, and die with symptoms of febrile marasmus. We now know two forms of inflammation which may attack con- tused wounds : 1. Rapid, progressive, septic inflammation, which begins about the wound during the first three or four days (rarely in less than twenty-four hours, and just as rarely after the fourth day), and which is caused by local infection from parts that decompose in the wound. 2. Progressive purulent inflammation, which is particu- larly apt to occur in wounds of the hands or feet during the cleansing of the wound from necrosed shreds of tissue, without the pus becom- ing ichorous, although butyric acid often formed in it. But, even when the wound has entirely cleaned off and granu- lated, when the inflammation is bounded, and the wound begins to cicatrize, new inflammation, with severe results, may begin. These secondary progressive inflammations of suppurating wounds, occur- ring even several weeks after the injury, and sometimes coming as unexpectedly as lightning from a clear sky, are of great importance, and are sometimes very dangerous. They are almost always of sup- purative nature, and may be fatal from intense, phlogistic, constitu- tional infection, just as often as the primary progressive suppurations. In some cases, also, they prove dangerous from their location, as in wounds of the head. These cases are so striking and tragical that we must give them special consideration. Suppose you have brought a case of severe crushing of the leg, with fracture, successfully through the first dangers. The patient has no fever; the wound granulates beautifully, and has even begun to cicatrize. Suddenly, in the fourth week, the wound begins to swell ; the granulations are croupous or spongy, the pus thin; the whole limb swells. The pa- tient again has high fever, perhaps repeated chills. The symptoms may pass off, and every thing go on in the old track ; but it often 166 CONTUSED AND LACERATED WOUNDS OF THE SOFT PARTS. turns out badly. In a few days the strongest man may become a corpse. Some time since such a case occurred in Zurich, in a fellow- student with a wound of the head ; it may serve you as a warning example. The young man received a blow over the left vertex ; the bone was injured very superficially ; the wound healed quickly by first intention ; only a small spot continued to suppurate. As the patient felt quite well, he paid no attention to the little wound, and went about as if perfectly well. Suddenly, in the fourth week, after a walk, he had severe headache and fever. The following day there was about a teaspoonful of pus collected under the cicatrix, which was evacuated by an incision. This did not have the desired beneficial effect on the general condition ; the fever remained the same. In the evening delirium began, then sopor. The fourth day the previously vigorous man was dead. It was easy to diagnose that there had been suppurative meningitis. This was proved on autopsy. Although at the spot, as big as a pea, where slight suppuration had been so long kept up, the bone was but slightly discolored by purulent infiltration, still the suppuration on, in, and under the dura mater was greatest at the part exactly corresponding to this point ; so that the new inflam- mation undoubtedly started from the wound. A short time since, here in Vienna, in private practice, I saw a perfectly similar case, also fatal, in a man who several weeks previously had received an appar- ently insignificant wound, from a piece of a soda-water bottle that burst, at the upper part of the forehead, along the margin of the hairy scalp. The inflammations occurring under such circumstances, as already remarked, are usually of a diffusely purulent character, but other forms accompany it, or occur spontaneously, such as diphtheritic in- flammation of the granulations {traumatic diphtheria, hospital gan- grene), inflammation of the lymphatic trunks (lymphangitis), and a specific form of capillary lymphangitis of the skin, erysipelas or ery- sipelatous inflammation ; and, lastly, inflammation of the veins (phle- bitis). Not infrequently all of these processes may be seen mixed together. We shall hereafter study these diseases more accurately, under accidental traumatic diseases. But here we must consider the causes of these secondary inflammations, before passing to the treat- ment of contused wounds; and, in so doing, we must anticipate somewhat. All of these forms of inflammation, and their reflex action on the organism, are so intertwined, that it is impossible to speak of one without mentioning the other. As causes of secondary inflammations in and around suppurating wounds that have begun to heal, we may mention the following : 1. Excessive flow of blood to the wound, such as may be induced by too INFLAMMATION OF CONTUSED WOUNDS. 167 much motion of the part, or by great bodily exertion, as well as by exciting drinks, mental agitation, in short, by any great excitement ; in wounds of the head, such congestions are particularly dangerous. Congestion, as caused by too tight bandages, may prove injurious in the same way. 2. Local or general catching cold ; about catching cold as a cause of inflammation we know little more than the simple fact that, under certain circumstances, which cannot be accurately defined, a sudden change of temperature induces inflammations, especially in a locus minoris resistentiw of an individual ; in a wounded person the wound is always to be considered as a locus minoris resistentim. The danger of catching cold after injury was certainly over-estimated formerly ; I hardly know of any certain examples. 3. Mechanical irritation of the wound. This is very important. The pus from the wound is never reabsorbed by the uninjured granulations ; but, if they be destroyed by mechanical manipulations, as by improper dressings, much probing, etc., which cause the wound to bleed frequently, new inflammations may be induced. Any foreign bodies in the wound might prove serious in this way, such as pieces of glass, lead, or iron, or sharp splinters of bone ; for the first changes which take place in the wound, the vicinity of such foreign bodies is less important, but, when, from muscular movements, and the motion communicated to the tissue from the arteries, the sharp angles of a foreign body keep up constant friction in a part, severe inflammation occurs after a time. 4, Chemical ferments y here I mention first soft foreign bodies, such as pieces of clothing, paper wads, which have entered the tissue through gunshot wounds ; these substances become impregnated with the secretions from the wound, then the organic material (paper, wool) decomposes, and acts as a caustic and ferment in the wound. I am in- clined to believe that necrosed splinters of bone also act rather as chem- ical than as mechanical irritants ; in the Haversian canals, or medullary cavity, they always contain some organic decomposing substance ; all such pieces of bone have a putrid smell when extracted ; if the sur- rounding granulations were partly destroyed by the sharp angles of such a fragment of bone, the putrid matter passes from it into the open lymphatic vessels, or possibly even into the blood-vessels, and so induces, not only local, but, at the same time, constitutional infec- tion. Necrosed tags of tendon and fascia at the bottom of suppu- rating wounds may induce the same results, although this rarely hap- pens. In hospitals, especially, there are some rare cases where we can find none of the above causes ; such occurrences naturally induce pe- culiar alarm, and attempts have been made to explain them by certain injurious influences of the hospital atmosphere, especially such as is filled with the smell of pus. Many circumstances speak against the 168 CONTUSED AND LACERATED WOUNDS OF THE SOFT PARTS. view that the injurious substances are gaseous ; by good ventilation the air of the hospital may be kept pure, but this is no protection against the affection in question ; moreover, we cannot excite inflam- mations by any of tne gases developing from pus or putrefying sub- stances, unless, perhaps, by sulphuretted hydrogen, when dissolved in water and injected into the subcutaneous cellular tissue. Putrid fluids and pus from other patients would not intentionally be brought in contact with wounds ; we have previously shown that the vicinity of the wound may, under some circumstances, be infected by pus from the wound, and excited to new inflammation. Hence there is little left but the supposition that the injuriously-acting substances are of a molecular, dust-like nature ; they may float about in the air of the hospital, but they may also adhere to the bandages, charpie, com- presses, etc., with which we dress the wounds, or to the instruments, forceps, probes, sponges, etc., with which we touch the wound. May they not be fungi, or other organic germs, whose nature we do not at present know, like those we know to excite fermentation ? This is possible, for in every cubic foot the air holds quantities of such germs, and in the hospital such organic germs of animal or vegetable nature might develop in the secretions from wounds, in the sputum or excrement, and the more so in proportion as the readily-decomposing secretions and excretions are collected in hospitals, or in badly- built water-closets and sewers. On this point we can only haz- ard conjectures, while we may make experiments with dry putrid sub- stances and dry pus, by powdering them, and then introducing them into the healthy tissue of animals. Such experiments have been made by 0. Weber and myself, and they have shown that both animal and vegetable putrid, dry substances, as well as dry pus, induce inflam- mation ; if we pulverize these substances, stir them up quickly with water, then inject them into the subcutaneous cellular tissue of ani- mals, they will excite progressive inflammation, just as putrid fluids and fresh pus do. Now, it must at once be acknowledged that in a hospital such injurious dust-like bodies may readily cling to dressings and bedclothes ; possibly, also, to instruments. In short, it is possible that the direct injurious influence of hospital air on a wound may be due to fine dust-like particles of putrid or purulent matter coming in contact with it from the dressings or instruments. There can be no doubt that such injurious materials may enter the body in other ways besides through wounds, as through the lungs ; indeed, we explain the occurrence of all so-called infectious diseases by the entrance in the or- ganism of substances which have a sort of fermenting influence on the blood ; but, whether the morbid materials which excite the infectious diseases chiefly occurring in the wounded be different from those arising INFLAMMATION OF CONTUSED WOUNDS. 169 from the wound itself, may be a disputed point, so far as we at present know. We shall return to this point when speaking of accidental traumatic diseases. You will suspect me of contradicting myself here, because in yesterday's lecture I said that no molecular body could en- ter the tissues through an uninjured granulation-surface. I must still claim this as usual ; a strong, uninjured granulation-surface is a de- cided protection against infection through the wound. But, when the infecting material itself is very irritating, so that it destroys the granulating surface by causing decomposition, a passage-way is opened for the poison to enter the tissues. Still more, there are certain sub- stances which are carried into the granulation-tissue, and perhaps even further, by the pus-cells. If you sprinkle a granulating surface on a dog with finely-powdered carmine, some cells take up the small carmine granules and wander with it into the granulation-substance ; after a time you find cells with carmine in the granulation- tissue. I consider this an abnormal retrograde movement of the pus-cells, which we generally believe to pass from the granulation-tissue to the surface of the wound ; it is true, no one has seen this. Nevertheless, from the above experiment, it is evident that even molecular substances may pass from without into the tissue of the edges of the wound, and, if these substances be very decomposable or cauterant, they will excite active inflammation. But all of the millions of molecular organisms in the atmosphere are not taken up by the wound, nor do they each induce inflammation. My belief is that all micrococci do not neces- sarily have a phlogogenous action, but only those which are formed in certain products of inflammation, such as decomposing pus or fluids of the body, putrid urine, etc., and which have there ab- sorbed the ferment. This is the most frequent cause of micrococ- cus in hospital ; hence its development there is to be combated with particular energy. I do not believe that these substances, whether lifeless or living molecules, are always the same, but I think they are very numerous, as are the causes of inflammation generally ; they may all have certain chemical peculiarities in common, as we might suppose from their similar action, although we know nothing about them, except this action ; they also differ somewhat in their mode of action on this or that tissue ; the absorbability of such sub- stances may vary with the part of the body, and possibly, also, with the individual ; but the large number of these injurious substances is, in fact, small as compared with the innumerable variety of organic substances generally. Febrile reaction is usually greater from contused than from incised wounds; according to our view, this is because, from the decomposi- tion, which is much more extensive in crushed than in incised parts, HO CONTUSED AND LACERATED WOUNDS OF THE SOFT PARTS. far more putrid matter enters the blood. If in any case the putrid matter is particularly intense, or very much of it is taken up (es- pecially in diffuse septic inflammations), the fever assumes the charac- ter of so-called putrid fever ; the state thus induced is called septi- cemia ; we shall hereafter study it more closely. If the suppurative inflammation extends from the wound, there is a corresponding- con- tinued inflammatory or suppurative fever ; this has the character of remittent fever with very steep curves and occasional exacerbations, mostly due to progress of the inflammation, or to circumstances that favor the reabsorption of pus. If we call the fever, that often, but not always, accompanies traumatic inflammation, simple traumatic fever ^ we may term the fever that occurs later " secondary fever" or " suppurative fever" This may immediately succeed the traumatic fever, if the traumatic inflammation progresses regularly; but the traumatic fever may have ceased entirely, and the wound be already healing, and when new secondary inflammations, of which we have fully treated, attack the wound, they are accompanied by new suppu- rative fever ; in short, inflammation and fever go parallel. Occasion- ally, indeed, the fever appears to precede the secondary inflammation, but this is probably because the first changes in the wound, which may be only slight, have escaped our observation. At all events, on every accession of fever that we detect, we should at once seek for the new point of inflammation, which may be the cause. I am far from asserting that it is necessary to measure the temperature in all cases of wounds ; undoubtedly any experienced surgeon, accustomed to examine patients, would know the condition of his patient without measuring the temperature, just as an experienced practitioner may diagnose pneumonia without auscultation and percussion ; but no one who understands the significance of bodily temperature doubts that its measurement may sometimes be a very important aid to diagnosis and prognosis. It is with it as with every other aid to observation ; it is not difficult to detect a dull percussion-sound in the thorax where it should not exist ; but the art and science of determining the sig- nificance of this dull percussion-sound in any given case must be learned ; so, too, with measurement of temperature : for instance, we must learn whether a low temperature in any given case be of good or bad omen. I shall enter into more detail on this subject in the clinic. Experience teaches that secondary fever is often more intense than primary traumatic fever. While it is most rare for the latter to begin with a chill (a slight chilliness after great loss of blood and severe concussion is not usually accompanied by high temperature), it is not at all so for a secondary fever to commence with severe "chill." INFLAMMATION OF CONTUSED WOUNDS. 17 1 We shall at once study this peculiar phenomenon more attentively. Formerly the chill was always regarded as essentially dependent on blood-poisoning ; if we now regard fever generally as due to intoxi- cation, we must seek some special cause for the chill. Observation shows that the chill, which is always followed by fever and sweating, is always accompanied by rapid elevation of temperature. If we ther- mometrically examine the temperature of the blood of a patient with chill, we find it high and rapidly increasing, while the skin feels cool ; the blood is driven from the cutaneous vessels to the internal organs. As already remarked, Traube considers this as the cause of the ab- normal febrile elevation of temperature. We shall not discuss this at present ; at all events, there is so great a difference between the air and the bodily temperature that the patient feels chilled. If we un- cover a patient with fever, who lies wrapped up in bed and does not feel chilly, he at once begins to shiver. Man has a sort of conscious feeling for the state of equilibrium in which his bodilv temperature stands to the surrounding air ; if the latter be rapidly warmed, he at once feels warmer, if it be rapidly cooled, he at once feels cool, chilly. This trivial fact leads us to another observation. This sensitiveness for warmth and cold, this conscious feeling of change of temperature, varies with the individual ; it may also be increased or blunted by the mode of life ; some persons are always warm, others ever too cold, while for others the temperature of the air is comparatively a matter of indifference. The nervous system has much to do with this. Ac- curate studies of Traube and Jbchmann have in fact shown that the nervous excitability of an individual has a great effect as to whether, in a rapid elevation of temperature of the blood, the change will be much perceived or not ; hence that in torpid persons, in comatose condi- tions, chills do not so readily occur with fever, as they do in irritable persons already debilitated by long illness. I can only confirm this from my own observation. Although I have a general idea that, where there is sufficient irritability, rapid elevation of temperature and chill chiefly occur when a quantity of pyrogenous material enters the blood at once, still I cannot deny that the quality of the material is also important. We know nothing of this quality chemically, but we may conclude that it has varieties, because both the fever-symp- toms and their duration often vary greatly, and that this does not solely depend on the peculiarities of the patient. According to my observations, in man reabsorption of pus and recent products of in- flammation is more apt to induce chills than is absorption of putrid matter, which is perhaps more poisonous and dangerous. I do not wish to weary you with too many of these considerations, and so shall return to the subject in the section on general accidental trau- 172 CONTUSED AND LACERATED WOUNDS OF THE SOFT PARTS. matic and inflammatory diseases, which you may regard as a continu- ation of this study of fever. I will only remark here that both the septic and purulent primary and secondary inflammations, with their accompanying fever, may also occur from incised wounds, especially after extensive operations (as amputations and resections). We have considered this condition along with contused wounds, because it complicates them much more frequently than it does ordinary incised wounds. Now we pass to the treatment of contused wounds. In many cases contused wounds require no more treatment than incised wounds ; the conditions for healing exist in both. Hence, in a contused wound it is only necessary to anticipate any accidents, or at all events to master them so that they may not become dangerous. In both respects we may do something. Formerly it was always sup- posed that the air with its oxygen and its ferments particularly favored the decomposition of dead, organic bodies, hence of contused parts ; to prevent this, the wound was excluded from the air, and, to prevent warmth acting as an aid to decomposition, the wounded part was kept cool. We attain both objects by placing the injured part in a vessel of cold water, whose temperature is always kept cool by ice. This treatment is called " immersion " or " continued cold-water bath." I first saw this used with excellent effect by my earliest teacher in surgery, Prof. JBaum, in G5ttingen. This mode of treatment is only really practical in the extremities ; in the leg as high as the knee, and in the arm to a little above the elbow. We place suitably-constructed arm and foot vessels filled with cold water in the patient's bed, and have the wounded extremity kept in it day and night. The patient's position should be such that he lies easily, and that the extremities may never press too hard on the edge of the vessel. This is all very simple ; you will often see this apparatus in my clinic. In the most common injuries of the hand, a basin with cold water is sufficient in private practice. In parts which cannot be kept in water in this sim- ple way, we try to exclude the air by applying moist linen compresses, which readily adapt themselves to the injured part ; over these we apply a rubber bag (or a bladder) filled with ice, which is to be re- placed as it melts. It is still more efficacious to wrap up a limb well and pack it in a vessel with ice. A third method of applying cold water is the so-called irrigation. For this we require special appara- tuses. The injured extremity is laid in a tin trough, supplied with an escape-tube. Above the extremity we place an apparatus from which a continued stream of cold water drops from a moderate height on the wound. Lastly, we may simply cover the wouDd from time tc time with compresses dipped in ice-water. TREATMENT OF CONTUSED WOUNDS. 173 I have seen all these modes of treatment in practice. Here is my opinion of them : none of them act certainly as prophylactics. In contused wounds of the hands and feet the water-bath is best ; for, under this treatment, extensive suppuration is rarest. To attain the same favorable results by the ice-treatment, we must cover not only the wound but the parts around with the ice-bladders ; pack the parts in ice. In applying cold-compresses, we shall only really obtain the effect of cold if we change the compresses every five minutes, for they warm very quickly, and the usual treatment with cold-compresses actually amounts to nothing more than keeping the parts moist; hence, this is, strictly speaking, no peculiar mode of treatment ; never- theless, as I have already remarked, most small contused wounds heal under it spontaneously, without our placing them under unnatural conditions by the use of cold. Irrigation is not a bad plan of treat- ment, but it is troublesome, and it is often difficult to avoid wetting the bed ; the condition of the wound subsequently does not differ from that in the more simple treatment by immersion or ice, so that I have not felt obliged to resort to irrigation. In France, this method is practised and highly esteemed by some surgeons. Apart from the prevention of accidents, for which all remedies are as useless here as venesection is in pneumonia, we have still in the above modes of treatment important means for combating the usual local accidents. I have still a few special remarks to make about the water-bath. As we here leave out of consideration injuries of the bones and joints, I know of no contraindication to it in contused wounds of the hand, forearm, foot, and leg. In most cases of these injuries the bleeding is so slight, and ceases so soon spontaneously, that the patient can place the extremity under water very soon if not immediately after the injury, without the occurrence of haemorrhage ; but the blood clinging to the part should first be washed off, the water itself be perfectly pure and transparent, and, if it becomes clouded by the secretion of the wound, it should be kept clear by frequent re- newals. Even when the wound is two or three days old, the water- bath may still be employed with advantage ; later, it is of little use. If the patients lie comfortably in bed with the tub, they are more contented and free from pain under this treatment than under any other. The temperature of the water may vary greatly without much changing the condition of the wound ; only ice temperature, and the high temperature obtained by cataplasms, cause a somewhat different appearance ; but from 54° to 90° or 100° F. it does not vary much in looks. Perhaps suppuration comes on a little sooner at the higher temperature, but the difference is not great. Hence, we may adapt 174 CONTUSED AND LACERATED WOUNDS OF THE SOFT PARTS. the temperature of the water to the feelings of the patient. At first the patients generally prefer a lower temperature (54°-68° F.), later a rather higher one (88°-95° F.) ; but there are also patients who, even during the first day, complain of chills if the temperature of the water falls below 68° F. Hence we see that it is rather indifferent whether we employ warm or cold water baths. In some persons, on the third or fourth day, there arises a state which renders immersion unbearable, that is, swelling of the epidermis of the hands or feet, and the accompanying tense, burning sensations, which somewhat re- semble the action of a blister. The thicker the epidermis, the more disagreeable this accident. It may be avoided by rubbing the injured extremity with oil, before placing it in the water, and adding a hand- ful of salt to the water ; this does no harm to the wound. An im- portant question is, How long shall continued immersion be employed ? Rules for this can only be given after considerable experience. I have found from eight to twelve days enough. After this we may leave the limb out of the water at night, enveloping it in a moist cloth cov- ered with oiled silk ; a few days later we may employ this dressing during the day also, and use the water-bath only morning and even- ing, or mornings alone, leaving the limb in it half an hour or an hour to bathe and cleanse it. Finally, we leave off the water entirely, and. treat the granulating, cicatrizing wound after the simple rules already given. The changes in wounds under this treatment are somewhat different from those previously described. In the first place, all goes on much slower ; sometimes, especially in the treatment with the cold-water bath, the contused wound looks as fresh for four or five days as when first received. The same thing is noticed for some time under the treatment with bladders of ice. This is not so astonishing as it at first seems, for, as is well known, decomposition of organic substances goes on more slowly in water than in the air. Subse- quently the pus usually remains on the wound as a flocculent, half- coagulated layer, and must be washed or syringed off to obtain a view of the subjacent granulations, which are infiltrated with water, and often quite pale. This observation is very important, and protects us from illusions in regard to the efficacy of the water-bath in deep sup- purations ; we might suppose that the pus flowed from the wound directly into the water and was there diffused, so that it would simply be necessary to place the suppurating part in water to have it always clean. The water-oath does not favor the escape of pus / it rather prevents it. Pus on the granulations, or in cavities, coagulates at once on contact with water, and usually remains on the wound ; wash- ing or syringing is necessary for its removal. Swelling of the granu- lations entirely prevents the escape of pus from deep parts. Hence TREATMENT OF CONTUSED WOUNDS. 1V5 we see, where there is suppuration from a cavity, that the water-bath is of no use, but is even injurious, and that an extremity should at once be removed from the water as soon as deep progressive inflam- mations extend out from the wound. By this we do not mean to ex- clude a half-hour's bath of the part. Should there be no progressive inflammations, there would be no particular harm from leaving the wound in the water for two, three, or four weeks, only the healing would be much retarded. In the water the parts remain greatly swollen ; the granulations are full of water (artificially cedematous), pale, and cicatrization and contraction of the wound will not occur. If you then remove the extremity from the water, the wound soon contracts ; in a few days the granulations look stronger, and the pus better ; healing progresses. Now I must say something about the continued treatment by ice. Suppose you cover the contused wound from the first with a bladder of ice ? Here, also, you will find that the crushed parts are very slowly detached, and that no smell arises from the wound, unless large masses of tissue become gangrenous ; to prevent the latter, if possi- ble, I apply charpie, or a thin compress wet with chlorine-water, next to the wound, and have it frequently renewed. If we now continue the treatment four to six weeks, all the necessary changes in the wound will go on very slowly and sluggishly ; the cicatrization and contraction of the wound are also very slow under the influence of the ice, and hence this method is entirely out of place if we desire to hasten the process of healing. Most surgeons believe that we may prevent severe inflammations by applying bladders of ice to the re- cent wounds ; hence you will find ice applied at once to most cases of contused wounds. Occasionally this proves very grateful to the patient, by relieving his pain, but it does not seem to me a prophy- lactic antiphlogistic ; for centuries, men have sought such a prophy- lactic, just as they have for one for inflammations of internal organs. By the application of ice to recent wounds, we can neither prevent sanio-serous infiltration, nor suppurative inflammations, at least, this is my opinion. As already stated, many believe in the prophylactic action of ice, and are convinced that by this means only they can save persons badly injured. I have become satisfied that the dangerous complications to wounds often occur in spite of the ice, and are not unfrequently wanting when ice is not used, when from the nature of the wound they might be expected. From what has been said, you might almost suppose that I consider ice an inefficient remedy that may be dispensed with, still, you will see it much employed in my clinic ; in my opinion, cold is one of the best antiphlogistics, especially in inflammation of an external part where it can act directly. Hence, 1 76 CONTUSED AND LACERATED WOUNDS OF THE SOFT PARTS. ice is proper where there is inflammation, especially if accompanied by great fluxion, with a tendency to suppuration of the wound. If inflammation of the cellular tissue, the sheaths of tendons or muscles, or of a neighboring joint begin, you should apply ice to the inflamed part, and thus avoid the excessive hyperemia, and so the increase ot the inflammation. You think I am here contradicting myself, when I say that ice is of no use in preventing the development of inflamma- tion about a wound, but it is of use in lessening the commencing inflam- mation and preventing its spread. But let me explain this by an ex- ample, and you will readily see the difference. When any one suffers from headache, he certainly would not think of being bled for every attack, to prevent inflammation of the brain; but, if the latter be really developing, venesection may be a very efficacious remedy to arrest its further development and spread. By the aid of ice, we do not always succeed in arresting the suppuration extending from the wound, but occasionally the ©edematous skin grows redder, becomes painful, and, when you press on it, a thin, serous, or sometimes quite consistent pus occasionally flows slowly from some of the angles of the wound. Under such circumstances, the retained pus, especially if bad smelling and ichorous, must be set free, and allowed to flow unobstructedly ; for this purpose, deep incisions should be made in the soft parts, and then kept open. When this should be done, and how it may best be done in individual cases, you will have to learn in the clinic. For probing such suppurating cavities, I prefer a slightly-curved silver catheter, which I pass through the wound to the end of the canal, then press the end up against the skin and here make the in- cision. For enlarging these so-called counter-opening 's, just as in other wounds, you use a tolerably long probe-pointed knife, straight or curved (JPottfs knife). As a rule, the counter-opening should not exceed an inch in length ; if necessary, we may make several of this length; in such cases there is usually no use in dividing the soft parts of the forearm or leg longitudinally, as was formerly taught. To prevent these new openings from closing again too soon, which, however, rarely happens, you may introduce several silk threads through the pus canals, tie the ends together, and leave them for a time. In place of these setons of silk or linen threads, caoutchouc tubes, with numerous lateral openings, have recently been used ; they have received the name of drainage-tubes, an expression taken from agricultural technology ; sometimes, at least, these tubes facilitate the escape of pus very well, but their principle is not new, nor can we accomplish such wonders with them as is claimed by Chassaignac, their inventor, who has written a book in two thick volumes about them. In making these counter-openings, you will not unfrequently strike on dead shreds of tendon or fascia, which should then be removed. TREATMENT OF CONTUSED WOUNDS. 177 The skilful use of the above remedies is an art of experience; what you cannot accomplish with them in suppuration, you will not accomplish with any thing else. One of our colleagues of former days would shake his head doubt- fully, if he heard that we had talked so long about the treatment of contused wounds and secondary suppurations, without having men- tioned cataplasms. " Tempora mutantur ! " Formerly cataplasms belonged to suppurating wounds as undoubtedly as the lid to the box, and now, three or four weeks may pass in my wards without cata- plasms being once employed for their original uses. The employ- ment of moist warmth, whether in the form of cataplasms or of thick cloths dipped in warm water, is useless in the treatment of contused wounds, and, in the treatment of secondary suppurations, it is occa- sionally injurious ; under them the wounds become permanently re- laxed, the soft parts swell, and healing is not advanced. Moreover, cataplasms only truly act as moist warmth when often renewed ; their renewal is tiresome, the poultice easily sours, or may be scorched, and finally, the whole mess cannot be carefully watched in a hospital ; a cataplasm covered with pus may be removed, new poultice added, and it may then be placed on another patient. In some hospitals at least half of the surgical patients wear poultices ; hundred-weights of grits and flaxseed, etc., for poultices, are used monthly in the surgical wards ; they are almost banished from my wards ; as occasion offers, I shall show you the cases where they may be used with advantage. Hence, little as I can recommend the use of moist warmth as the ordinary treatment of wounds, I consider it very suitable in those where there is an extensive hard (fibrinous diphtheritic) infil- tration of the cellular tissue. In these cases the moist warmth is not only pleasant to the patient, by rendering the tense skin soft and pliable, but it appears to aid removal of the hardened inflammatory products, either by their reabsorption or breaking down into pus. In such cases I apply warm moist cloths covered by some waterproof material. Hitherto I have not mentioned that the absolute rest of an injured part is always necessary ; it may seem singular that I should mention it at all ; you may think this should be considered a matter of course. I lay particular stress on it, because injurious substances are taken from the wound into the blood ; hence every muscular movement, and every consequent congestion of the wound, in short, every thing that drives the blood and lymph more strongly into the vicinity of the wound, may eventually prove injurious. 12 178 CONTUSED AND LACERATED WOUNDS OF THE SOFT PARTS. Nor is an elevated position of the injured part to be neglected where it can be tried. You may readily prove on yourselves that gravity has something to do with the movement of the blood ; if you let your arm hang perfectly relaxed for five minutes, you will feel a heaviness in the hand, and the veins on the back of the hand will look swollen ; if, on the contrary, you elevate the hand for a time, it will become whiter and smaller. While debilitated persons are lying in bed, in the morn- ing, for instance, their faces look fuller than when they have borne the head erect for the day. Recently, VblJcmann has strongly recom- mended vertical suspension of the arm as a powerful antiphlogistic in inflammations of the hand; consequently, I have employed this method, and in cases of cutaneous inflammations have found it very efficacious ; it appears to do less good in deep inflammations, as of the wrist. Hereafter, the water-bath, ice-treatment, and cataplasms, will prob- ably give place to the open treatment of wounds, from which I have seen very good results in contused as well as in incised wounds (p. 95), I did not say this at the commencement of the section, because I do not consider my experience of this mode of treatment sufficiently ex- tensive for me to give a final judgment. The dreaded access of air to the surface of the wound, even the air of badly-ventilated hospitals, is not, in my opinion, so injurious as dressings and sponges of doubt- ful cleanliness ; the idea that air is injurious to suppurating wounds rests chiefly on the observation that the entrance of air to abscess cavities with rigid walls, and into serous sacs, usually induces sup- puration ; apart from the fact that, in many of these cases, it is not proved that it is indeed the entrance of air which excites the inflam mation, we must also attribute much of the blame to the fact that in the pus-sacs the air is warmed and impregnated with watery vapor from the pus ; this enclosed air now becomes a true hatching-place for those minute organisms which cause decomposition, and which are always more or less present in the atmosphere. Every observing housekeeper knows that meat or game hanging in the open air spoils far less readily than when shut up in a cupboard, even when the air in the latter is kept cool by ice. Free air does no harm to the wound, imprisoned air is very dangerous. I have already mentioned (p. 96), that a wound treated openly from the start has no bad smell, unless large shreds of tissue on it become gangrenous ; in accordance with this also, flies do not deposit their eggs in open wounds, while they are apt to creep into dressings to do so ; I must say these observa- tions surprised me very agreeably, because I feared that flies would render the open treatment of wounds impossible in summer. The longer I carefully try the open treatment of wounds, the more it sat- TREATMENT OF CONTUSED WOUNDS. 179 isfies me. No method guarantees a perfect immunity from acci- dental traumatic diseases, and even in the open treatment of wounds there may be superficial adhesions and formation of pockets in which decomposition of the secretion may occur. We must learn to antici- pate such things. Many surgeons now prefer the method of occlusion by thoroughly disinfected dressings and early application of drainage-tubes for car- rying off secretion, after Lister's method. It is asserted that by this means a milder course is secured, as in subcutaneous contusions ; that the shreds of dead tissue do not decompose, but dry up without smell and are thrown off with very little suppuration; that the blood-clots are either directly organized or escape from the wound as odorless gray crumbs ; that acute septicaemia and progressive sup- purations never occur ; and that the severe accidental traumatic dis- eases, of which we shall hereafter speak, are never developed. I recommend this method to you most warmly. In general I would advise you, as students and practitioners, to study and accurately learn one of the modes of treatment recom- mended to you, and not to be easily led off from your therapeutic principles. In your practice employ what you have well and thor- oughly learned. Believe me, your patients and yourselves will thus come out the best. In the treatment of secondary inflammation, most careful prophy- laxis is to be recommended ; avoidance of congestion of the wound, catching cold, all mechanical and chemical irritations, and especially infection. Hereafter, when speaking of accidental traumatic diseases in general, we shall state what may be done in the latter respect by ventilation and proper use of the room in the hospital. For avoiding local infection of the wound by dressings or instruments, we would give the following advice: Be exceedingly careful in the dressings, cleansing the wound, choice of compresses, charpie, and wadding ; al- ways see to the most perfect cleanliness of the mattresses, straw beds, coverings, oiled muslin, parchment-paper, and in short of every thing about the patient. The bleeding of the wound on dressing should be avoided by carefully syringing it with EsmarcKs wound-douche, of which there should be two or three in every ward ; we should never apply dry compresses, charpie, or wadding to the wound, but should previously wet all these articles in solution of chloride of lime or other antiseptic, and later, when the wound begins to cicatrize, with lead- water ; and for removing the pus we should never use sponges, nor should we use them in operating, but do it all by syringing or by wiping off with wadding wet with water or chlorine-water ; if we cannot avoid the use of sponges, they should be new ones, and disinfect 180 CONTUSED AND LACERATED WOUNDS OF THE SOFT PARTS. them at once with hypermanganate of potash or carbolic acid. Or- ganic beings never develop in chlorine-water (aqua chlori, with equal parts of water), solution of chloride of lime (chloride of lime two drachms, water one pint), nor do they in lead-water, in solution of acetate of alumina (alum 20, acetate of lead 35, water 400), of permanganate of potash, or in sulphide of soda 50, glycerine 25 ? water 450 (Polli, Minnich). Lister has recommended carbolic acid as a peculiarly efficacious antiseptic ; it may be diluted with oil, glycerine, or water, or made into a paste with chalk, and then spread on tin-foil, to make an air-tight covering for the wound. " Deodor- izing powder" (coal-tar and plaster of Paris), sprinkled dry on putre- fying sores, is also good where the wound is not too deep. These different modes of application, under the name of " Lister's dress- ing," have been regularly tried, and it is a good thing for the pro- fession to study and become thoroughly acquainted with any method of treatment. Lister has accomplished one good, at least, in having directed attention to the antiseptic treatment, and given it a definite practical value. I consider carbolic acid as a very serviceable anti- septic, but have not found it to possess any special advantage over the remedies and modes of treatment above mentioned. You must pay special attention to the instruments with which you touch the wound, such as probes, forceps, knives, scissors ; every thing should be wiped before being used, or, if it be at all suspicious, it should be quickly rubbed with cleaning powder. In order to carefully ob- serve all these precautions, you must be perfectly satisfied of their necessity. If, in spite of all our care, decomposition, gangrene, or phleg- monous inflammation has started in the contused wound or its vicin- ity, we must abandon the protective dressing directly applied to the wound; the cavities of the wound and abscesses should be dilated and filled with wads of charpie or wadding dipped in a strong anti- septic solution. After numerous experiments I always return to acetate of lead and alumina ; it is a very active desiccant and deodor- ant, without disagreeable odor. It is true, the dirty dark-gray color, due to sulphuret of lead from the sulphuretted hydrogen in the sanies and the lead in the antiseptic solution, is disagreeable, but it is harmless. Till the mortified tissues have been entirely saturated with the solution of acetate of alumina and lead, the dressing must be frequently changed, or the solution may be poured over the dress- ing every two hours. When the wound begins to clean up, one dressing daily is enough ; on simple granulating wounds this solution is too drying, irritating, and painful ; later we use protective dress- ings or salves. Next to acetate of alumina and lead, chloride of lime LACERATED WOUNDS. 181 solution is most active ; but as its effect is due to development of chlorine, it is very temporary, and dressings with this substance must be frequently renewed to deodorize or disinfect well. Gly- cerine is a good disinfectant, and acts excellently if poured freely on the dressing every two hours. If applied early, it withdraws so much water from the necrosed shreds of tissue that there is no smell ; but if decomposition has once begun, its deodorizing effect is very slow. After using it freely for three or four days, the wound often becomes so red and sensitive that we must refrain from further ap- plications. Solutions of chloride of zinc are also recommended for washing out purulent cavities ; I have rarely found its superficial cauterizing effect very obstinate. Strong solutions of carbolic acid in oil or water (five per cent, and over), when applied to large sur- faces, not unfrequently cause dangerous symptoms of poisoning, and are not so effectual for deodorizing, mummifying necrosed tissues, and limiting putrefaction, as acetate of alumina and lead. I have no personal experience of the antiseptic properties of salicylic acid (recommended by Kolbe and Thiersch), or of sulphite of soda (rec- ommended by Polli and Minnich). If, however, secondary inflammations attack the wound, they should be treated as already advised; retained pus should be removed, foreign bodies extracted, etc., then the wound treated with ice, per- haps, till all is brought in order again, and the patient free from fever. In such cases shall we prescribe any thing for our patients besides cooling drinks and medicines, regulating their diet, etc. ? The febris remittens not unfrequently accompanying such suppurations renders the patient dull, peevish, and often sleepless. Two remedies are proper here — quinine and opium ; quinine as a tonic and febrifuge, opium as a narcotic, especially in the evening, to secure a night's rest. With such patients I usually pursue the following method : As long as they are little if at all feverish, I give nothing ; if they grow feverish toward evening, in the afternoon I give two doses of quinine (five grains each) in solution or powder, and in the evening before bedtime from the eighth to half a grain of muriate of morphia, or a grain of opium. As soon as the fever ceases, I stop these medi- cines ; you must especially avoid liberality with opium, when it is not required, for it is constipating. Now a few words about lacerated wounds. In general, these are less dangerous than contused wounds, because they are more exposed, and we have no need to fear that the injury is deeper than we can see ; we perceive how the skin, muscles, nerves, and vessels are torn ; 182 CONTUSED AND LACERATED WOUNDS OF THE SOFT PARTS. healing by first intention may be tried for and succeeds occasionally although suppuration generally occurs. But stay, ruptures are not always exposed; there are also subcutaneous ruptures of muscles, ten- dons, or even of bones, without there having been any contusion. A person wishes to leap a ditch, and makes a start, but fails in his at- tempt ; he falls, and feels a severe pain in one leg, and limps on it. On examination, just above the heel (the tuberositas calcanei), we find a depression in which the thumb may be laid ; the motions of the foot are imperfect, especially extension. What has happened ? The tendo Achillis has been torn from the calcaneus by the great muscular ac- tion. The same thing occurs with the tendon of the quadriceps femoris, which is attached to the patella, with the patella itself, which may be torn in two, with the ligamentum pateihe, with the triceps brachii, which may be torn from the olecranon, and generally carries a piece of the latter along with it. Here you have a few examples of such subcutaneous ruptures of tendons; I have seen subcutaneous rupture of the rectus abdominis, of the vastus externis cruris, and other muscles. These simple subcutaneous ruptures of muscles are not serious injuries ; they are readily recognized by the disturbance of function, by the depression, which may be seen and still better felt, which at once occurs, but subsequently is masked by the effused blood. The treatment is simple : rest of the part, placing it so that the rup- tured ends may be brought in contact by relaxation of the muscle, cold compresses, lead-water lotions for several days ; after eight or ten days the patient can generally rise without pain ; at first there is a connective-tissue intermediate substance, which soon condenses so much, by shortening and atrophy, that a firm tendinous cicatrix forms; the course is just the same as in subcutaneous division of tendons, of which we shall speak in the chapter on deformities. Functional disturbances of any considerable amount rarely re- main ; occasionally there is some weakness of the extremity and loss of delicate movements, especially in the hand. For such subcutaneous rupture of muscles and tendons to be caused by contusion, the crushing force would have to be very great; such a contusion would probably run a bad course ; extensive suppu- rations and necroses of tendons might be expected. Here, again, you see how varied may be the course of injuries apparently the same, according to the mode of their origin. In injuries by machinery there is often such a wonderful combination of crushing, twisting, and lacerating, that even with great experience it is very difficult to give any accurate prognosis of their course. The favorable course of cases, where small or even large portions of a limb (as the hand) are torn off, is especially worthy of mention. I have seen two cases where LACERATED WOUNDS. 183 fingers were torn off; I will briefly narrate one of them: a mason was employed on a scaffolding, and suddenly felt it giving way under him; Fig. 40. Fro. 41. Fig. 42. Central end of a torn brach- ial artery. Torn-out middle finger, with all its Arm torn out, with scapula tendons. and clavicle. 184 CONTUSED AND LACERATED WOUNDS OF THE SOFT PARTS. from the roof of the house against which the scaffold rested there hung a loop; the falling man grasped this, but only succeeded in get- ting the middle finger of the right hand through the loop ; he huno- a moment and then fell to the ground. Fortunately, the height was not great, and he was not injured, but the middle finger of the right hand was gone; it was torn out at the joint between the first phalanx and the metacarpal bone, and it still hung in the loop. The two tendons of the flexors and that of the extensor remained attached to the fin- ger ; they had been torn off just at the insertion of the muscles ; the man dried his finger with the tendons, and subsequently carried it in his purse as a memento of the circumstance. I saw a similar case in the clinic at Zurich (Fig. 41). Cure resulted without much inflam- mation of the forearm, and actually no treatment was required. In Zurich I saw two cases where the hand was torn out ; in one case there was enough skin remaining to leave the healing to itself, in the other case an amputation of the forearm was necessary. Both cases terminated favorably. In war it is not very rare for arms and legs to be torn from their sockets by large cannon-balls. I have also seen a case where a boy fourteen years old had the right arm with the scap- ula and clavicle so torn from the thorax, by a wheel of machinery, that it was only attached at the shoulder by a strip of skin two inches wide (Fig. 42). The axillary artery did not bleed a drop; both ends were closed by torsion (Fig. 40). The unfortunate fellow died soon after the injury. Tearing out of entire extremities is usu- ally quickly fatal. CHAPTER V. SIMPLE FB AC TUBES OF BONES. LECTURE XIV. Causes, Different Varieties of Fractures. — Symptoms, Diagnosis. — Course and External Symptoms.— Anatomy of Healing, Formation of Callus. — Source of the Inflamma- tory Osseous New Formation. — Histology. Gentlemen : Hitherto we have been exclusively occupied with injuries of the soft parts ; it is time to consider the bones. You will find that the processes that Nature excites for the restoration of the parts are essentially the same that you already know ; but the circum- stances are more complicated, and can only be fully understood when you are perfectly acquainted with the mode of healing in the soft parts. Every person knows that bones may be broken, and again be firmly united ; this can only be done by bony tissue, as you will at once see; hence it follows that new bony substance must be formed ; the cicatrix in bone is usually bone ; a very important fact, for, if this were not the case, if the broken ends only grew together by connec- tive tissue, as divided muscles do, the long bones particularly would not be united firmly enough to support the body, and after the sim- plest fractures many men would be cripples for life. Still, before fol- lowing the process of the healing of bones to its more minute details, a study that has always been pursued with great zeal by surgeons, I must tell you something about the origin and symptoms of simple fractures ; I say " simple or subcutaneous fractures " in contradistinc- tion to those accompanied by wounds of the soft parts. Man may even come into the world with broken bones : the bones of the foetus may be broken, while in the uterus, by abnormal con- tractions of that organ, or by blows or kicks on the pregnant abdomen, and such intra-uterine fractures generally heal with considerable dislo- cation ; as we shall see in other instances, the vis medicatrix natures 186 SIMPLE FRACTURES OF BONES. is a better physician than surgeon. Of course, fractures of the bones may occur at any age, but they are most frequent between the ages of twenty-five and sixty years, for the following reasons : The bones of children are still pliable, and hence do not break so easily ; if a child falls, it does not fall heavily. Old people have, as is commonly remarked, brittle, friable bones ; or, anatomically expressed, in old age the medullary cavity grows larger, the cortical substance thinner ; but old persons are less in danger of fractures of the bones, because their lack of strength prevents their doing hard and dangerous work. It is during the age when men are most exposed to hard work that injuries generally and fractures especially are most liable to occur. The less frequency of fractures among women is due to the variety of their occupation. It is also due entirely to external circumstances that the long bones of the extremities, especially of the right side, break more frequently than those of the trunk. It is evident that diseased bones, which are already weak, break more easily than healthy ones ; hence certain diseases of the bones greatly predispose to fractures, especially the so-called English disease, " rickets," which is due to deficient de- posit of lime-salts in the bones, and only occurs in children; also softening of the bones or "osteomalacia," which depends on ab- normal dilatation of the medullary cavity, and thinning of the cor- tical substance, and which is, to a great extent, accompanied by a " fragilitas ossium," and even by total softness and flexibility of the bones. As special causes of fractures, we have the two following : 1. The action of external forces, the most frequent cause ; this action may vary in the following ways : the force — for instance, a blow or kick — meets the bone directly, so that it is crushed or broken ; or the bone, especially a long bone, is bent more than its elasticity permits, and breaks like a stick that is bent too much ; here the force acts indi- rectly on the point of fracture. In the mechanism of the latter variety, instead of the single hollow bone, you may consider a whole extremity or the entire spinal column as a stick, flexible to a certain extent, and on this supposition found your idea of the indirect action of the force. Let us have a couple of examples to explain this : If a heavy body falls on a forearm at rest, the bones are broken by direct force ; if a person falls on the shoulder, and the clavicle is broken obliquely through the middle, this is the result of indirect force. In both cases there is usu- ally contusion of the soft parts ; but in the latter case it is more or less removed from the point of fracture ; in the former at that point, which evidently is to be regarded as less favorable. 7 2. Muscular action may, though rarely, be the cause of fracture. As I already indicated, when speaking of the subcutaneous rupture of VARIETIES OF SIMPLE FRACTURES. 187 muscles, the patella, the olecranon, and part of the calcaneus also, may be torn off by muscular action, that is, obliquely fractured. The way in which the bones break under these varied applications of force varies, but some types have been formed that you should know. First, we distinguish complete and incomplete fractures. Incomplete fractures are again subdivided into fissures, i. e., clefts, cracks ; they are most frequent in the flat bones, but occur also in the long bones, especially as longitudinal fissures accompanying other fractures ; the cleft may gape or appear simply as a crack in glass. Infraction, or bending, is a partial fracture, which, as a rule, only occurs in very elastic, soft bones, and especially in rachitic children; you may best imitate this fracture by bending a quill till its concave side breaks in. In children, such infractions of the clavicle are not rare. What we mean by splintering is evident ; the most frequent causes are machine-cutters, sabre-strokes, etc. Lastly, the bone may be perforated without entire solution of continuity, as by a punctured wound through the scapula, or a clean shot through the head of the numerus. The latter variety of injury is called a perforated fracture. Complete fractures are subdivided into transverse, oblique, longi- tudinal, dentate, simple, or multiple fractures of the same bone, com- minuted; all of these expressions explain themselves. Lastly, we must mention that persons as old as twenty years may also have a solution of continuity in the epiphyseal cartilages, although this is rare, and the long bones break more readily at some other point. Frequently it is easy to recognize that a bone is broken, and a non-professional person may make the diagnosis with certainty; in other cases the diagnosis may be very difficult, and occasionally can only be a probable one. Let us take up the symptoms one after another. First, accustom yourself to examine every injured part accurately, and compare it with healthy parts ; this is particularly important in the extremities. You may not unfrequently know what the injury is by simple ob- servation of the injured extremity. You ask the patient how it hap- pened, having him undressed meantime, or, if this be painful, have his clothes cut off, that you may accurately examine the injured part. The manner and severity of the injury, the weight of any body that has fallen on the part, may indicate about what you have to expect. If you find the extremity crooked, the thigh bent outward, for instance, and swollen, if suggillations appear under the skin, if the patient can- not move the extremity without great pain, you may with certainty decide on a fracture ; here you need no further examination to decide on the simple fact of a fracture, it is not necessary to put the patient to any pain on this account ; you have only to examine with the 188 SIMPLE FRACTURES OF BONES. hands to find how and where the fracture runs ; this is less necessary, on account of determining the treatment, than to be able to decide whether and how recovery will result. In this case you have made the diagnosis at a glance, and in surgical practice it will often be easy for you to recognize very quickly the true state of affairs, when you are accustomed to use your eyes thoughtfully, and when you have ac- quired a certain habit in judging of normal forms of the body. Never- theless, you should know perfectly how you arrived at this sudden diagnosis. The first point was the mode of the injury, then the de- formity ; the latter is caused by two or more pieces of bone (frag ments) having been displaced. This dislocation of the fragments is due partly to the injury itself (they are driven in the direction that they maintain, from the bending of the bone), partly to the muscular action which no longer affects the entire bone, but only a part ; the muscles are excited to contraction, partly by the pain from the injury, partly by the pointed ends of the bone ; for instance, the upper por- tion of a fractured thigh-bone is elevated by the flexors, the lower por- tion is drawn up near or behind the upper fragment by other muscles, and thus the thigh is shortened and deformed. The swelling is caused by the effusion of blood (we speak here of a fracture that has just oc- curred) ; the blood comes chiefly from the medullary cavity of the bone, and also from the vessels of the surrounding soft parts which have been crushed or torn by the ends of the bone ; it looks bluish through the skin, if it works up to the skin, as it gradually does. The patient can only move the extremity with great pain ; the cause of this disturbance of function is evident, we need waste no words on it. If we examine each of the above symptoms separately, none of them, either the mode of injury, the deformity, swelling, effusion of blood, or functional disturbance, will alone be evidence of a fracture, but the combination is very decisive ; and you will often have to make such a diagnosis in practice. But all these symptoms may be absent when there is fracture. If there has been an injury, and none of the above symptoms are well developed, or only one or other of them distinctly exists, manual examination must aid us. What will you feel with your hands ? You should learn this thoroughly at once. I so often see practitioners feel about the injured part for a long time with both hands, causing the patients unspeakable pain, and after all finding out nothing by their examination. By the touch you may perceive three things in fractures : 1. Abnormal mobility, the only pathognomonic sign of fracture ; 2. You may often detect the course of the fracture, and often whether there are more than two fragments ; 3. By moving the fragments you will often experience a rubbing and cracking of the fragments against each other, the so-called " crepita- SYMPTOMS OF SIMPLE FRACTURES. 189 tiori* — strictly to crepitate means to crackle ; this is a sound, and still We say, we feel crepitation ; it is no use to object to this ; this is an abuse of the word, which has so gone into practice, however, that it cannot be rooted out, and every one knows what it means. An edu- cated touch usually feels at once all that can be detected by the touch ; hence it is unnecessary to make the patient suffer long under this examination. Crepitation may be absent or very indistinct ; of course, it only exists when the fragments can be moved, and when they are quite near each other; if they be considerably displaced laterally or be drawn far apart by muscular contraction, or if there be blood between the fragments, no crepitation can be felt, and it is often difficult to detect when the bones lie deep. Hence, if we detect no crepitation, this, in opposition to all the other symptoms, does not prove that there is no fracture. Still, even where there is crep- itation, you may mistake its origin ; you may have a feeling of fric- tion under other circumstances ; for instance, the compression of blood coagula or fibrinous exudations may give a feeling of crepitation ; this soft crepitation, which is analogous to pleuritic friction, you should not and will not mistake for bony crepitus after some experi- ence in examination ; when opportunity offers, I shall hereafter call your attention to other soft friction-sounds which occur especially in the shoulder-joint in children and old persons. For experienced sur- geons, in certain fractures severe pain at a fixed point is enough for a correct diagnosis, especially as in contusions the pain on grasping the bone is mostly diffuse, and rarely so severe as in fracture. If we are examining an extremity, it is best to seize it with both hands at the suspected point, and attempt motion here ; this manipulation should be firm, but not rough, of course. I must add something about the dislocation of the fragments ; this may vary, but the displacements may be divided in various classes, which from time immemorial have had certain technical designations, which are still used, and which consequently must be explained. Simple lateral displacement is called dislocatio ad latus ; if the fragments form an angle like a half- broken stick, it is called dislocatio ad axin. If a fragment be rotated more or less on its axis, we call it dislocatio ad peripheriam y if the broken ends be shoved past each other vertically, it is a dislocatio ad longitudinem. The expressions are short and distinctive, and easily remembered, especially if you represent to yourselves the displace- ments by diagrams. We now pass to a description of the course of healing of a frac- ture. You will rarely have the opportunity of seeing what happens when no bandage is applied, as the patient generally sends early for a surgeon. But occasionally the laity undervalue the importance of 190 SIMPLE FKACTURES OF BONES. the injury ; several days pass before the pain and duration of the affection at last cause the patient to apply to a surgeon. In such cases, besides the symptoms of fracture already given, you find great oedema, and in some few cases inflammatory redness of the skin about the point of fracture ; under such circumstances the examination may be very difficult ; occasionally the swelling is so considerable that an exact diagnosis as to the course and variety of the fracture is out of the question. Hence the earlier we see a fracture the better. The subsequent external changes at the point of fracture may best be studied on bones that lie superficially, and which cannot be sur- rounded with a bandage, as on fracture of the clavicle. After seven to nine days, the inflammatory oedematous swelling of the skin has subsided, the extravasated blood has run through its discolorations and goes on to reabsorption, and a firm, immovable, hard tumor lies around the point of fracture ; this is larger or smaller according to the dislocation of the fragments ; it is, as it were, poured around the frag- ments, and in the course of eight days becomes as hard as cartilage ; this is called callus. Pressure on it (the fragments can with difficulty be felt through it) is painful, though less so than previously ; subse- quently the callus becomes absolutely firm, the broken ends are no longer movable, the fracture may be regarded as healed ; for the clav- icle this requires three weeks, in smaller bones a shorter, and in larger ones a much longer time. But this does not end the external changes ; the callus does not remain as thick as it was ; for months or years it grows thinner, and, if there was no dislocation of the fragments, after a time no trace of the fracture will remain ; if there was a dis- location that could not be reduced by treatment, the ends of the bone unite obliquely and after absorption of the callus the bone remains crooked. To find out the changes that take place in the deeper parts, how the fractured ends unite, we try experiments on animals. We make artificial fractures on dogs or rabbits, apply a dressing, kill the ani- mals at various stages, and then examine the fracture ; we may thus obtain a perfect representation of the process. These experiments have been made innumerable times. The results have always been essentially the same ; but, if we speak of rabbits alone, there are certain variations which, as proved by numerous experiments, depend on the amount of dislocation and of extravasation of blood. Hence, before showing you a series of such preparations, I must give you the result of these investigations, and exemplify them by a few diagrams ; then you will hereafter readily understand the slight modifications. We shall first confine ourselves to what we can see with the naked eye and a lens. If you examine a rabbit's leg three or four days after FORMATION OF CALLUS. 191 the fracture, and, while it is firmly held in a vice, saw the bone longi- tudinally, you find the following : the soft parts about the fracture are swollen and elastic ; the muscles and subcutaneous cellular tissue look fatty ; the swollen soft parts form a spindle-shaped, not very thick tumor about the seat of fracture. About the broken ends we find some dark extravasated blood, and the medullary cavity at the same point is somewhat infiltrated with blood. The amount of this escaped blood varies, being sometimes very slight, again considerable. At the point of fracture the periosteum may be readily recognized, and is in- timately connected with the other swollen soft parts (which are the seat of plastic infiltration). Occasionally it is somewhat detached from the bone at the point of fracture. The whole thing looks about as follows (Fig. 43) : Fig. 44. Fig. 43. ..C Longitudinal section of a fracture of a rabbit's bone, four days old; a, ex- travasated blood ; b, swollen soft parts external callus ; c, periosteum. Diagram of a longitudinal section of a fifteen-day-old fracture of a long bone ; a, internal callus ; 6, inner, c, outer layer of ossification of the external callus; d, new periosteum. The di- mensions of the callus, in proportion to the entire lack of dislocation of the fragments, are represented as far too great, but this facilitates the pre* liminary understanding of the case. If we now examine a fracture in a rabbit after ten or twelve days, we find that the extravasation has either entirely disappeared, or that only a slight amount remains. I will not raise the question as to whether it has been entirely reabsorbed, or has partly organized to callus. The spindle-shaped swelling of the soft parts has mostly the appearance and consistence of cartilage, and has also the same micro- scopical characteristics ; in the medullary cavity also we find young 192 SIMPLE FRACTURES OF BONES. cartilage formations in the vicinity of the fracture. The broken bone sticks in this cartilage as if the two fragments had been dipped in sealing-wax and stuck together ; the periosteum is still tolerably dis- tinct in the cartilaginous mass, but it is swollen, and its contours are indistinct. Although there are traces of ossification even now, they do not become very decided or evident to the naked eye for some days (perhaps the fourteenth to the twentieth day after the fracture). Then we see the following (Fig. 44) : In the vicinity of the fracture there is young soft bone : 1. In the medullary cavity (a). 2. Immediately on the cortical layer (£>), and some distance up and down beneath the periosteum, which has disap- peared in the whole spindle-shaped callus tumor. 3. In the periphery of the callus, which is still mostly cartilaginous (c). The periosteum which previously lay within the callus has now disappeared ; in its place a thickened layer of tissue has formed on the outside of the callus, which represents the periosteum (d). The young bone-sub- stance is soft, white, and in it we may see a kind of structure ; for small parallel pieces of bone, corresponding to the transverse axis of the bone, may be distinctly seen, especially on examination with a lens. The cartilaginous callus formed from the surrounding soft parts, into which the periosteum also has been partly transformed, now forms an enclosed whole, and ossifies entirely, partly from without (c), partly from within (h), till finally the ends of the bone stick in bony, as they previously did in the cartilaginous callus. This bony callus, which consists entirely of spongy bone-substance, is called by Du* puytren "provisional callus" As it is completed, the bone is usually firm enough to be again capable of function ; but the callus does not remain in its present condition any more than a recent cica- trix of the soft parts does. A series of changes occurs in it in the course of months or years, for up to this point you may still compare the union to that by sealing-wax, which is not a true organic union. So far the firm cortical substance is only united by loose young bone- substance ; the medullary cavity is plugged with bone ; the healing is not yet solid ; Nature does far more. We shall now study the subsequent changes ; they are confined to the spongy substance of the callus. At a certain time this ceases to increase, and then changes, by reabsorption of the bony substance that has formed in the medullary cavity (Fig. 45), and by the disappearance of a great part of the external callus. Meantime, formation of new bone has commenced between the fractured cortical layers, so that this has become solid by the time the external and internal callus disap- pears. This connecting bony substance between the fragments grad- ually increases in density, to such an extent that it becomes as hard as UNION OF FRACTURES. 193 the bone in the normal cortical substance. In case there has been little or no displacement of the fragments, the bone is thus so fully restored that we can no longer determine FlG> 45 the point of fracture, either on the living person or the anatomical preparation. The above changes occur in a long bone of a rabbit, where there has been little displacement, in about twenty-six or twenty-eight weeks, but in the long bones of man last much longer, so far as we can judge from preparations that we accidentally have the opportunity of ex- amining,; The entire process, so excellently con- trived by Nature, is essentially the same as what we observe in the normal devel- opment of the long; bones ; for there, too, Longitudinal section of a fractured F , ' . , , . . bone from a rabbit, after twenty- the same reabsorption and condensation four weeks. Progressive reab- . .... ill sorption of the callus. Kestora- take place m the medullary canal and the tion of the medullary cavity, . . , , „ ., , , natural size ; after Gurlt. cortical layers or the long bones, as we have just studied in formation of callus. Except the regeneration of nerves, no such complete restoration of a destroyed part takes place in any other part of the human bodj as we have seen occurs in the bones. I must still add a few remarks about the healing of flat and spongy bones. In the case of the first, which we see most frequently in the healing of fissures of the cranial bones, the development of provi- sional callus is very slight, and occasionally appears to be entirely wanting. In the scapula, where dislocation of small, or half or wholly detached fragments is more apt to occur, external callus forms more readily, although even here it never becomes very thick. On the union of spongy bones, too, in which, as a rule, there is also but little dislocation, there is less development of external callus than in the long bones ; while, on the other hand, the cavities of the spongy sub- stance in the immediate vicinity of the fracture are filled with bony substance, of which part, at least, subsequently disappears. As may readily be imagined, the conditions will be somewhat more complicated when the ends of the bone are much dislocated, or when fragments are entirely broken off and displaced. In such cases there is such a rich development of callus, partly from the entire sur- face of the dislocated fragments and from the medullary cavity, and partly in the soft parts between the fragments, that for some distance all the fragments are embedded in a bony mass, and organically glued 13 194 SIMPLE FRACTURES OF BONES. together. The larger the circle of irritation from the dislocated frag- ments, the more extensive the formative reaction. In man we most frequently have the opportunity of seeing callus formation in greatly dislocated fractures of the clavicle, where it is very evident that the extent of the new formation of bony substance is directly proportional to the amount of dislocation. You may read- ily understand how, in this way, with extensive formation of neo- plastic bone-substance, there may be perfect firmness, even with great deformity at the point of fracture. Still, one would hardly believe, without satisfying himself on the point, from preparations, that with time, even in such cases, Nature has the power of restoring, not only the outward shape of the bone (except the curvature and rotation), but also the medullary cavity, by reabsorption and condensation, Fig. 46. Fia. 47. Fracture of the tibia of a rabbit, with great dislocation, with extensive formation of callus, after 27 days. Natural size, after Skutsch. (Gurlfs Fractures, vol. i., p. 270.) Old united oblique fracture of a human tibia ; the ends of the fragments have been rounded off by absorption, the external callus reabsorbed ; formation of the me- dullary cavity incomplete. Size dimin- ished. Gurlt, 1. c, p. 287. Numbers of points, nodules, inequalities and roughnesses of all sorts, that are formed on the young callus in recent cases, so disappear in the course of months and years, that in their place there is only left some dense, compact, cortical substance. FORMATION OF NEW BONE. 195 It will now be interesting to investigate the true origin of the newly-formed bony substance ; is it produced by the bone itself, by the periosteum, by the surrounding soft parts, or is the extravasated blood transformed into bone, as was believed by old observers? Must formation of cartilage always precede that of bone, or is this unnecessary? These questions have received various answers, till quite recently. To the periosteum, especially, great power of pro- ducing bone has at one time been ascribed, at another denied. In what follows, I will briefly give you the results of my investigations on this subject. The new formation that results from the fracture occurs in the medulla and Haversian canals of the bone, in the periosteum, and in- filtrated in the adjacent muscles and tendons ; possibly the extrava- sated blood may also have something, but very little, to do with the formation of the callus ; a large extravasation is disturbing here, as in healing of wounds of the soft parts, for part of it must be organized, while the remainder is absorbed. The inflammatory new formation here, also, at first consists of small round cells, which increase greatly in number, and infiltrate the tissues mentioned, and then almost take their place. Before following the fate of this cell-formation further, I must briefly consider its course in the Haversian canals. The cell-in- filtration in the connective tissue of the medullary cavity offers nothing peculiar, except that the fat-cells of the medulla disappear in the mass as the wandering cells take possession of the territory. Suppose the following figure (Fig. 48) to represent the surface, or the fractured surface, of a bone on which, as you know, the Haversian canals open; in these canals lie blood-vessels, surrounded by some connective tissue. If this bony surface be in the vicinity of a fracture, numerous Fio. 4a Diagram of a longitudinal section through the cortical snhstance of a long bone, o, surface : %, Haversian canals, with blood-vessels and connective tissue ; c. periosteum. Magnified 403 diameters. 196 SIMPLE FRACTURE OF BONES. cells first come between the connective tissue in the Haversian canals ; should this cell-infiltration be very rapid, it would entirely compress the blood-vessels, and cause the death of the bone, a process which we shall hereafter learn. Bat, if the cell-increase in these canals goes on slowly, their walls are gradually absorbed, as it would appear, by the inflammatory new formation itself; the canals are dilated, the cells fill them, and at the same time the blood-vessels increase by forming loops. From the observations of CoTinheim, we must suppose that in inflammation of bone, also, the young cells in the Haversian canals are not newly formed, but are white blood-cells escaped from the ves- sels. This has no effect on the subsequent course. Now, let us turn to the changes of form that we observe in the osseous tissue. As the connective tissue of the osseous canals is con- tinuous, both with the periosteum and medulla, the cell-infiltration into the bone, periosteum, and medulla, is also continuous. The cause of the atrophy of bone along the walls of the Haversian canals, which takes place in this, as in most other new formations in the bone, is difficult to explain; the disappearance of the connective tissue and muscular substance, as well as of other soft structures, when the in- flammatory new formation occurs in them, is less strange ; but it is truly remarkable that hard bony substance should thus be dissolved. This process might be represented by the following diagram (Fig. 49) : Fie. 49. Diagram of inflammatory new formation in the Haversian canals, a, surface ; b 5, Haversian canals, dilated, filled with cells and new vessels ; c, periosteum. Magnified 400 diameters. You see that the dilatation of the osseous canals is not regular, but of uneven widths ; the bone looks as if gnawed out ; this is not necessarily so, the atrophy of the bone may be more regular ; accord- ing to my idea, these irregularities result from the collection of cells in groups, or from looping of the vessels, which press against the FORMATION OF CALLUS. 19 7 bene and cause its atrophy. ~Virchow and others believe that these protuberances correspond to the nutrient territory of certain bone- cells, which in this process aid in reabsorption of the bone. I think I have refuted this, by showing that even dead portions of bone and ivory are also affected by the inflammatory new formation ; we shall speak more of this when treating of pseudarthrosis. At present it is not known how the lime-salts are dissolved in this process ; I think orobably the new formation in the bone develops lactic acid, which changes the carbonate and phosphate of lime into soluble lactate of lime, and that this is taken up and removed by the vessels ; but this is only hypothesis. It would also be possible for the organic basis of the bone, the so-called osseous cartilage, to be first dissolved by the inflammatory neoplasia, and then there would be a breaking-down of the chalky substance, whose molecules would be subsequently re- moved, even if undissolved. Although I have conversed with many chemists and physiologists on this point, none of them have given me a simple explanation of this process, nor could they indicate any mode of experimenting that might aid in solving the question. In the above diagrams, if we suppose the fractured surface where there is no periosteum, in place of the surface of the bone, you will understand how the new formation (the young callus) grows from it out of the Haversian canals as above described, similar neoplasia from the other fragment meets and unites with it, as in healing of the soft parts. It is evident that the bone through which the inflam- matory neoplasia thus grows must become porous, from the reabsorp- tion that takes place on the walls of the canal ; if you macerate a bone in this stage, till the young neoplasia decomposes, the dry bone will appear rough, porous, gnawed, while young bone-substance is deposited on it and in its medullary cavity. I must again repeat that in drawings and descriptions we have, for the sake of clearness, made the callous formation appear much more extensive than it really is, and that here, as in wounds of the soft parts, the regenerative processes do not usually extend very far or very deep, but are merely enough for healing, rarely in excess. In this whole explanation we have not mentioned the bone-cells or stellate bone-corpuscles ; I am convinced that they have as little to do with these processes as the fixed connective-tissue cells, and that the bone-substance, like the soft parts, is dissolved by a certain amount of inflammation, and replaced by new. So far we only know the neoplasia in the state where it consists essentially of cells and vessels, as the soft parts do under the same circumstances ; if there was retrogression to a connective-tissue cica- trix here as there is there, we should h^ye no solid bone formed, but a 198 SIMPLE FRACTURE OF BONES. connective-tissue union, pseudoarthrosis (from ipevdrjg, false ; apftpuoiq, joint), a false joint ; we shall hereafter describe these exceptional cases. Under normal circumstances the neoplasia now ossifies, as you already know. This ossification may either occur directly or after the inflamma- tory neoplasia has been transformed to cartilage. You know that both of these modes are seen in normal growth of the bone ; direct ossifica- tion of young cell-formation, for instance, in the periosteum of the growing bone, or formation of cartilage with subsequent ossification, as at first in the entire skeleton and in growth of the bones length- wise. Callus from fractures varies greatly in this respect in men and animals. In rabbits the callus is always changed to cartilage before ossification, as it also is in children. In old dogs the callus usually ossifies directly, as in the human adult ; we are far from knowing the causes of these differences. To obtain a histological representation of these processes, let us return to our former diagram (Fig. 49) ; now imagine that the cells, lying in the spaces caused by reabsorption in the Haversian canals and surface of the bone, soon ossify and first fill these spaces (Fig. 50), then collect on the surface and in the medulla. Fig. 50. Diagram of ossification of inflammatory neoplasia on the surface of the bone and in the Haver- sian canals. Osteoplastic periostitis and ostitis. Magnified 400 diameters. and thus form the external and internal callus. Periostitis and ostitis, which lead chiefly or exclusively to the. formation of new bone, we call osteoplastic ; in the present case the callus is the result of this. FORMATION OF CALLUS. 199 As previously remarked, the periosteum is used up in the neopla- sia and in ossifying callus, in its place, externally around the callus, a thick connective-tissue layer develops, from which new periosteum is formed. I will show you a few more preparations in explanation Fig. 51. Artificially-injected external callus, of slight thickness, on the surface of a rabbit's tibia, in the vicinity of a five-day-old fracture. Longitudinal section— a, callus ; b, bone. Magnified 20 diameters. Fia. 52. HP; of the process in the periosteum. You see (Fig. 51) the peculiar course of the vessels almost at right angles to the bone, which enter the bone through the young callus. The ossification of the callus begins, mantle-like, around these vessels, and the little columns which first appear in the external callus are thus formed (see remarks on Fig. 44). You have a good representation of the formation of external (periosteal) and internal (endosteal) callus in the following (incomplete) transverse sec- tion of the tibia of a dog, from the immediate vicinity of an eight-day- old fracture, in which you must also observe the vessels of the cortical sub- stance, which are considerably dilated as compared with normal (Fig. 52). Lastly, observe the following prepa- ration. It is an eight-day-old, already ossified, external callus on the surface Artificially-injected transverse s section of Q f ^e tibia of a dog, magnified 250 the tibia of a dog, from the immedi- °' ° ate vicinity of an eight-day-old frac- times (Fip;. 53). ture. a, internal callus; 5, external ; \ & / cc, cortical layer of the bone. Magni- If we now view the process as a fled 20 diameters. r . whole, we see that the cell infiltra- tion in the bone itself, as well as in all the surrounding parts, aids in the formation of callus, and that hence the periosteum plays no ex- clusive osteoplastic role. This might have been concluded a priori, 200 SIMPLE FRACTURE OF BONES. because if the periosteum alone formed the external callus, as was formerly supposed, the portions of the bone free of periosteum, as those places where tendons are attached to the bone, could form no callus ; this is directly contradicted by observation. In normal growth, also, the periosteum does not by any means play the im- portant part ascribed to it in the formation of bone ; for we may just as correctly regard the layer of young cells lying on the surface of the bone, and extending into the Haversian canals, as belonging to the bone, as to refer it to the periosteum. x^mMismi Ossifying callus on the surface of a hollow hone, near a fracture. Longitudinal section magnified 800. As appears, the ossifying callus is not limited to the periosteum, but extends in between the muscles. Recent investigations concerning the growth of bones, made by J. Wolff, render it very probable that they increase in all directions by interstitial deposit of young osseous tissue, and hence that growth by apposition through the epiphyseal cartilages and perios- teum can no longer be regarded as the sole source of increase in length and thickness ; such a mode of growth is placed beyond a TREATMENT OF FRACTURES. 201 doubt by Wegner's excellent work on the osteoplastic action of phos- phorus on growing bones. I will not conceal from you that the view which I have obstinately maintained, that the bone-cells in new osseous formations do not pro- liferate, but remain quite passive, is much disputed ; since Cohn- heim has shown the passiveness of the stabile connective-tissue cor- puscles in inflammation, there does not seem so much strangeness about my view, which was advanced years ago, and was founded on numerous observations ; still, the explanation of the preparations in question is not simple enough to permit only one view. Recently, by very careful investigations about the histological changes during the transformation of provisional into definitive callus, Lossen has tried to show that the bone-cells in the former take an active part in the formation of vascular canals in the latter by enlarging and changing position. I can agree with this entirely without abandoning the above views, for the provision-callus is like the young osteophytes of calcified connective tissue, like certain boundary-layers between car- tilage and bone. I have no doubt that the cells of this " osteoid car- tilage" ( Virchow), like the cells of hyaline cartilage, proliferate to true bone. But this is not the place to enter more deeply into the histological details, which, great as is their intrinsic interest, have no essential influence on the definitive formation of the new development of bone. LECTURE XV. Treatment of Simple Fractures. — Reduction. — Time for applying the Dressing, its Choice. — Plaster of Paris and Starch Dressings, Splints, Permanent Extension. — Retaining the Limb in Position. — Indications for removing the Dressings We shall pass at once to the treatment of simple oi subcutaneous fractures, especially fractures of the extremities, for these are by far the more frequent, and they particularly require treatment by dressings, while those of the head or trunk are to be treated less by dressings than by appropriate position, as is taught in the lectures on special surgery and in the surgical clinic. The indications we have to consider are, simply to remove any dislocations and to keep the fractured extremity in the correct ana- tomical position till the fracture is healed. First, the fragments are to be replaced; sometimes this may 202 SIMPLE FKACTURE OF BONES. be unnecessary, as when there is no dislocation, for instance, in some fractures of the ulna, fibula, etc. In other cases it is very difficult, and cannot always be done perfectly. The obstacles to the reposition may be in the position of the fragments themselves ; one fragment may be wedged into another, or a small fragment lies between the chief ones, so that the latter cannot be brought together accurately ; fractures of the lower articular extremity of the humerus are very obstinate in this respect, for small fragments may be so dislocated that neither flexion nor extension of the elbow-joint can be performed perfectly ; hence its functions remain permanently impaired. Muscular con- traction forms a second obstacle to the reposition of the fragments ; the patient involuntarily contracts the muscles of the broken limb, thus rubs thejragments together or presses them into the soft parts, causing severe pain ; this muscular contraction is occasionally almost tetanic, so that, even by great force, it is hardly possible to overcome the opposition. Indeed, formerly these difficulties were, to some ex- tent, insurmountable; and, although attempts were now and then made to attain the object by dividing tendons and muscles, it was often only possible to attain an imperfect reposition. All these diffi- culties were at once removed by the introduction of chloroform as an anaesthetic. Now, in all cases where we do not readily succeed in reposition, we anaesthetize the patient with chloroform, till his mus- cles are perfectly relaxed, and we can then usually place the frag- ments in position without difficulty. Some surgeons go so far as to use chloroform in almost all cases of fracture, partly for the examina- tion, partly for the application of the dressing. This is unnecessary, and may even prove very unpleasant, for some persons, especially those in the habit of drinking, at a certain stage of the anaesthesia are affected with spasmodic contractions of the extremities, so that, in spite of being carefully held by strong assistants, they rub the frac- tured ends against each other with fearful force, and we must be very careful that a sharp fragment does not pierce the skin. This should not frighten you from using chloroform in fractures, when it is neces- sary, but simply warn you against being too free with it. The meth- od of reposition is usually as follows : The fractured part is grasped by two strong assistants at the joints above and below the point of fracture, and regular, quiet traction employed, while the surgeon holds the extremity at the point of fracture, and, by gentle pressure, attempts to force the fragments into position. All sudden, impul- sive, forced traction is useless, and should be avoided. Here you have to notice two technical expressions ; we term the traction on the lower part of the extremity, extension, that on the upper part, counter-extension. In fractures, these are both made by the hands. TREATMENT OF FRACTURES. 203 while in dislocations we must occasionally resort to different mechan- ical appliances. By the above method accurate reposition will only be impossible when, from excessive swelling or from peculiarly un- favorable dislocation of the fragments, we are unable to correctly recognize the variety of the displacement. From our present ideas, which are based on a large number of observations, the sooner reposition is made after the occurrence of the fracture, the better ; we then at once apply the bandage. This was not always the belief, but formerly the adjustment of the frac- ture and the application of the dressing were delayed till the disappear- ance of the swelling, which almost always occurs if a dressing is not at once applied. It was feared that under the pressure of the dress- ing the extremity might mortify, and the formation of callus would be hindered ; with certain cautions in the application of the dress- ing, the former may very readily be avoided, and there is little truth in the latter belief. Regarding the choice of the dressing also, surgeons have of late reached an almost unanimous opinion. It may be regarded as a rule, that a solid, firm dressing should be applied as early as possible in all cases of simple subcutaneous fractures of the extremities y this may be changed altogether two or three times, but in many cases does not need renewal. This mode of dressing is called the immovable or fixed, in contradistinction to the movable dressings, which must be renewed every couple of days, and are only provisional dressings. There are several varieties of firm dressings, of which the most serviceable are the plaster of Paris, starch, and liquid glass. I shall first describe the plaster dressing, and show its application, as it is the one most frequently used, and answers all requirements in a way that can scarcely be improved. Plaster of Paris JBandage. — After adjustment of the fragments, the broken limb is extended and counter-extended by two assistants, then one or more layers of wadding applied over the point of fracture, and over parts where the skin lies directly over the bone, as over the crest of the tibia, the condyles, and malleoli. Now it is best to en- velop the limb with a new fine flannel roller-bandage, so as to make regular pressure on it, and cover all parts that are to be surrounded by the plaster-bandage. In hospital and poor practice, where we can- not always have flannel, we may use soft cotton or gauze bandages. Now comes the application of the plaster-bandages prepared for the purpose ; the plaster-bandage that I here have is cut from a very thin gauze-like stuff; it is prepared by sprinkling finely-powdered plaster (modelling plaster) over the unrolled bandage and then rolling it. In private practice a number of these bandages of various sizes may be 204 SIMPLE FRACTURE OF BONES. prepared beforehand and kept in a well-closed tin box. Here in the hospital, where these plaster-bandages are much used, they are pre- pared two or three times a week. This bandage you place in a basin of cold water and let it soak through, then apply it like any roller- bandage to the extremity prepared as above described. Three or at most four thicknesses of this plaster-bandage suffice to give the dress- ing the requisite firmness. In about ten minutes good plaster be- comes stiff enough for us to lay the extremity loose on the bed ; in half an hour or an hour, the dressing becomes as hard as stone and quite dry; the time required for hardening depends partly on the quality of the plaster, partly on how much you have moistened the bandage. After many comparisons with other modes of applying the plaster-bandage, I have found this the most practical ; but I must mention some modifications of the way of handling the plaster and of the material of the bandage. For instance, we may rub the plaster into the common muslin or flannel bandages, which makes the dress- ing somewhat heavier and firmer ; but this is not necessary and the loose gauze is very much cheaper than muslin-bandage. If the band- age does not appear sufficiently firm, we may apply a layer of plaster- paste over the dressing ; this plaster-paste is to be made with water, and spread on the bandage very quickly with the hand or a spoon ; it. should not be prepared till we wish to use it, as it stiffens very quick- ly. The plaster-dressing as made with roller-bandages was first in- troduced by a Dutch surgeon, Mathysen / this method was first pub- lished in 1832 ; but it has only become well known since 1850 ; it has been spread through Germany chiefly by the Berlin school. A differ- ent mode of applying the plaster-dressing is by different strips of bandage ; JPirogoff first hit on this method from lack of bandages in the army ; all kinds of material were cut into the shape of splints, then drawn through thin plaster-paste and laid on the broken limb, then the whole was coated with plaster-paste and a firm capsule was thus made. Subsequently the same surgeon made a special method of this ; he cut old coarse sail-cloth into certain patterns for each limb, and applied it in the above manner. Lastly, the so-called many-tailed bandage of Scultetus was used in the same way as a plaster-bandage. The foundation of the bandage has also been modified in various ways ; it has even been used without wadding or any under-bandage, the whole limb being simply covered with oil so that the plaster- bandage, being applied directly, might not adhere to the skin by the fine hairs. Others have employed thick layers of wadding without any under-bandage. Lastly, thin wooden splints or strips of tin have been lately used in it, as we shall hereafter see ; this may have certain advantages in fenestrated bandages. TREATMENT OF FRACTURES. 205 I have intentionally represented all these modifications of the plaster-bandage as only exceptionally useful, all of them having cer- tain objections as compared with the method first described. A more careful criticism of these modifications here would lead us too far. For persons unskilled in the matter, the removal of the plaster- bandage is quite difficult, but you may see that any of my nurses will do it with astonishing quickness. It is simply done as follows : with a sharp, strong garden-knife we divide the plaster-bandage, not per- pendicularly but rather obliquely, as far as the under-bandage, then remove the bandage entire, like a shell ; we may also employ the plaster-scissors proposed by Szymanoicsld or those of JBruns. We use this capsule in some other cases as a provisional dressing. Starch-Bandages. — Before plaster-bandages were known, we had in the starch-bandage an excellent material for the immovable dressing. The starch-bandage was perfected and introduced chiefly by the Belgi- an surgeon Seutin (f 1862) ; it is only during the last twelve years that it has given place to the plaster-dressing, but it is still used oc- casionally. The application of the wadding and under-bandage is the same as in the plaster-dressing, but then we apply splints, cut from moderately thick pasteboard and softened in water, to the limb, and fas- ten them on with bandages thoroughly soaked in starch-paste ; we now apply wooden splints till the dressing has hardened, which at the ordi- nary temperature requires about twenty-four hours. Compared to the plaster-dressing this has the disadvantage of hardening much more slowly ; we may improve this somewhat if we use gutta-percha splints instead of pasteboard, these may be softened in hot water, and adapted to the extremity. Gutta-percha bands, such as are used in factories, are very useful as splints. It cannot be denied that the introduction of gutta-percha into surgery is to be regarded as a great advantage ; but it is too costly to be used in practice for every simple fracture, although thick splints of this material harden even quicker than plaster. The dressing with roller-bandages prepared with plas- ter is so cheap and firm that it will certainly not be displaced again by starch-bandages, now that it has been introduced into practice. Instead of plaster, solutions of dextrine, pure white of egg, or simple mixture of flour and water, were formerly employed; they have all gone out of use, but it is well for you to know the usefulness of these substances, which are in every house, and which we may well employ as provisional dressings. Liquid-glass Dressings. — Instead of starch, we may employ the liquid glass of the shops (silicate of potash). On applying the dress- ing, we paint this on the muslin-bandages with a large brush, after having made a substratum of wadding as above described. The liquid 206 SIMPLE FKACTURE OF BONES. glass dries quicker than starch, but not so soon as plaster, nor does it become as hard as the latter ; this dressing does for fractures with no tendency to displacement ; if we wish to fix dislocated fragments of bone by the liquid-glass dressing, we must strengthen it by applying splints. I doubt not the time will soon come when every country physician will always keep a few plaster-splints ready prepared ; in spite of them, provisional dressings remain useful. These consist of band- ages, compresses, and splints, of various materials. You may make splints of thin boards, shingles, cigar-boxes, pasteboard, tin, leather, firmly-plaited straw, the bark of trees, etc., and, for bandages, must often content yourselves with old rags, muslin, torn into strips and sewed together; hence, in the practical courses on bandaging, it is necessary for you to learn to make use of the most varied materials. It is not our intention here to introduce to you every thing that may be used in the way of dressing, but I must still speak briefly of a few things. As may be readily seen, the object of the splints is to make the bone immovable by supporting it firmly on various sides ; this may be attained by external, internal, anterior, and posterior, narrow wooden splints; we may, however, employ hollow splints, so-called gutters. Hollow splints are only good when made of plia- ble material, as leather, thin sheet-iron, wire-gauze, etc. ; an absolutely stiff, hollow splint would only do for certain persons. Besides these mechanical aids, there is another method of keeping broken limbs in position, namely, permanent extension. This is particularly indicated in cases where there is great tendency to shortening, to dislocatio ad longitudinem. Attempts have been made to attain this extension by attaching weights by various mechanical contrivances, by continued traction made by weights hung to the injured limb, by the double- inclined plane, where the weight of the leg is used as the extending weight. Since, during the past two years, I have unexpectedly seen such excellent effect from permanent extension with weights in pain- ful contractions at the hip and knee joints, I am compelled to believe that this method may also eventually prove very serviceable for the gradual adjustment of dislocated fragments of bone. Among the arrangements of this nature with which I am acquainted, V. Dum- reieher^s so-called railroad apparatus best fulfils the object of perma- nent extension, but it is too costly and complicated to come into extensive use in private practice ; it is, doubtless, the intention of the inventor to employ it chiefly in cases where the dislocation is difficult to overcome. [Dr. Gurdon BucTc's apparatus for fractured thigh is about as efficacious and much simpler.] The double-inclined plane, represented by a thick roller-cushion applied under the hollow of the TREATMENT OF FRACTURES. 207 knee, may occasionally be employed as a suitable fixation apparatus in fracture of the neck of the femur in old persons. We must still mention some auxiliary appliances which we have to employ to keep the broken limb in good position after it has been dressed ; for the upper extremity, in most cases, a simple, properly- applied cloth, a mitella, or sling, in which the arm is laid, suffices. Patients with fractured arm or forearm may be permitted to go about with a plaster-bandage and a sling during the entire treatment, with- out interfering with the favorable healing. For keeping broken lower extremities in position, there are a number of mechanical aids, of which the following are the most serviceable : sand-bags, narrow sacks filled with sand, about the length of the leg ; these are placed both sides of the firm dressing, so that the limb may not move from side to side ; for the same purpose we may use long, three-sided pieces of wood, cut prismatically, which are laid together, so as to form a gutter. For some cases a sack, loosely filled with chaff or oats, is sufficient ; we make a hollow in it length- wise, and the leg is to be placed in this. If we desire firmer supports, we use fracture-boxes, narrow, long, wooden boxes, open at the upper end, so that the leg may be placed in them ; and the sides are made to turn down, so that the extremity may be carefully inspected, without moving it; the elevation of these fracture -boxes may be suited to the convenience of the patient. Lastly, we must mention the swing, which is usually made with a gallows, or strong bow, that is brought over the foot of. the bed, and to which the limb is suspended in any sort of a fracture-box, or hollow splint [or Dr. Nathan Smith's anterior splint], so that it may swing about; in restless patients especially, this has certain advantages. All these apparatuses, which, although more rarely employed than formerly, are still occasionally useful, you must learn to apply ; you will have opportunity for this in the surgical clinic. Of late we rarely apply these apparatuses in the lower extremity, as my former assistant. Dr. His, who has brought the application and elegance of the plaster-bandage to an extraordinary state of perfection, applies a well-padded wooden splint, three or four inches wide, to the under side of the leg, making it reach somewhat below the heel and as high as the knee, or, in fractures of the thigh, as high as the middle of the thigh. The limb lies firmly on this board, if the mattress be not too uneven : if we wish to attain still greater firmness, we may lay a board the width of the bed over the lower third of the mattress, and on this place the limb, with its plaster-dressing and supporting splint. In the numerous double fractures of both lower extremities that came to the Zurich hospital, this supporting apparatus did excellent service. 208 SIMPLE FRACTURE OF BONES. The old form of plaster-moulds has been recently strongly advo- cated again by Dr. M. Muller; we have tried it again, but it bears no comparison with the plaster-bandage. Sentin tried to increase the advantages of firm dressings by giving aids that might enable patients with fractured lower limbs to go about to some extent. For instance, a patient with a broken leg may have a broad leather strap passing over the shoulder, and buckled just above the knee, so that the foot will not touch the floor, and then let him go on crutches. But I advise you not to carry these experi- ments with your patients too far ; at all events, I only allow my patients to make such attempts three weeks after the occurrence of the fracture, otherwise oedema readily occurs in the broken limb, and some patients are so clumsy in the use of crutches, that they are apt to fall, and, although this may only cause slight concussion of the limb, it is still injurious. Lastly, we have to discuss how long the dressing should be left on, and the causes that might induce us to remove it before the cure is complete. The decision as to whether a dressing is too tightly applied is entirely a matter of experience ; the following symptoms must guide the surgeon : If there be swelling of the lower part of the limb, as of the toes or fingers, which are usually left exposed, if' these parts become bluish red, cold, or even senseless, the dressing should be removed at once. If the patient complains of severe pain under the dressing, it is well to remove it, even if we can see nothing to cause it. In judging of the exhibitions of pain, we should know the patients ; some always complain, others are very indolent, and show their feelings but little ; however, it is better to reapply the bandage several times uselessly than once to neglect its removal at the right time. I cannot too strongly urge you always to visit, with- in twenty-four hours at most, every patient to whom you apply a fixed dressing ; then your patient will certainly not come to grief, as un- fortunately too often happens, from the carelessness and laziness of his surgeon. A series of cases has been published where, after the application of a firm dressing, the affected limb mortified, and re- quired amputation ; from these cases it was decided that firm dress- ings were always improper, while the fault was chiefly due to the surgeon. Just think how little trouble we have in treating fractures now, compared to former times, when the splints had to be renewed every three or four days ; now you need only apply a dressing once. But you must not think you have got rid of all trouble in the appli- cation of dressings. The application of the firm dressing requires just as much practice, dexterity, and care, as did dressing with splints. If you are first called to a fracture when it is two or three TKEATMENT OF FRACTURES. 209 days old, when there is already considerable inflammatory swelling, you may even then apply the firm dressing, but must apply it more loosely, and with plenty of wadding. This dressing will be too loose, and should be renewed in ten or twelve days, when the swelling has left the soft parts. It will chiefly depend on the looseness of the bandage, and the greater or less tendency to dislocation, when and how often the dressing should be removed during the treatment. Swelling, if not accompanied by considerable contusion, is no contra- indication to a carefully-applied firm bandage ; nor do large or small vesicles, full of clear or slightly-bloody serum, present any great ob- jection ; such vesicles result not unfrequently from contused fractures with extensive rupture of the deep veins, since, from obstruction to the flow of venous blood, the serum readily escapes from the capilla- ries, and elevates the hard layer of the epidermis into a vesicle; we puncture these vesicles with a needle, gently press out the fluid, and apply some wadding, and they soon dry up. It is the same with slight superficial excoriations of the skin ; we are only rarely obliged to remove the dressing and apply another, when new vesicles form, as we may know by the pain. The length of time that a firm dressing must remain on for the different fractures you will learn partly in the clinic, partly from spe- cial surgery ; I simply mention here, as the limits, that a finger may require a fortnight, a thigh sixty days, or more, for healing. If you apply the plaster-dressing immediately after the fracture, dislocation having been completely removed, the provisional callus will always be less, and hence firmness result later, than where there is some dis- location and the dressing is applied later ; but this has no effect on the formation of definitive callus, and the actual union of the frac- tured ends of the bone. 14 CHAPTER VL OPEN" FBA CTURES AND S UPP UP A TION OF B ONE. Difference between Subcutaneous and Open Fractures in regard to Prognosis. — Vari- eties of Cases. — Indications for Primary Amputation. — Secondary Amputation. — Course of the Cure. — Suppuration of Bone. — Necrosis of the Ends of Fragments. We shall now pass to complicated or open fractures. When we speak simply of complicated fractures^ we usually mean only those accompanied by wounds of the skin. Strictly speak- ing, this is not exact, because there are other complications, some of them much more important than wounds of the skin. If the skull be fractured, and part of the brain-substance crushed, or some ribs broken and the lung wounded, these are also complicated fractures, even though the skin should remain uninjured. But, since in these cases the complications themselves are more important for the organism than the fracture is, we usually term such cases contusion of the brain, or injury of the lung, with fracture of the skull or ribs. But we shall not here enter on the subject of injuries of internal organs by frag- ments of bone, because very complicated states of disease are occa- sionally induced in this way, whose analysis you would not now un- derstand. For the present let us limit ourselves to fractures of the extremities, accompanied by wounds of the skin, which we shall call open fractures, and which will give us trouble enough in their course and treatment. In speaking of the course of simple contusions without wounds, and of contused wounds, I have already shown you how readily reab- sorption of extravasated blood and the healing of contused parts go on, as long as the process is subcutaneous, but how much the condi- tions change if the skin also be destroyed. The chief dangers in such cases are, as you may remember, decomposition in the wound, exten- sive necrosis of crushed or dead parts, progressive suppuration, and accompanying protracted, exhausting fever, while we have scarcely PROGNOSIS IN OPEN FRACTURES. 211 mentioned the severe general diseases, erysipelas, putrid-blood poison- ing, pyaemia, tetanus, and delirium tremens. The difference between •contusions and contused wounds is even more strongly marked in simple and compound fractures, as regards course and prognosis. While in many cases we can scarcely call a person with simple frac- ture sick (we have not spoken of fever there, for it rarely occurs), and under the present convenient treatment such an injury is rather an inconvenience than a misfortune, a compound fracture of a large bone of an extremity, or sometimes even of a finger, may induce severe, and too frequently fatal, disease. But, not to alarm you too much, T will at once add that there are many grades of danger even in open fractures, and, moreover, that their treatment has been much improved of late. It is very difficult and important, but not always possible, to make a correct prognosis about an open fracture at once. The life or death of the patient may occasionally hang on the choice of the treatment the first few days, so that we must study this subject more accurately. The symptoms of an open fracture are of course essentially the same as of the subcutaneous, except that discoloration from extravasated blood is often wanting, because at least part of the blood escapes through the wound. The fractured ends not infrequently, project from the wound, or lie exposed in it, so that a glance may suffice for the diagnosis of an open fracture. But this is not enough. "We must do our best to ascertain how the fracture was caused, whether by direct or indirect force, and how great the force ; if it was accompanied by crushing and twisting ; whether arteries and nerves have been torn ; if the patient lost much blood, and what is his condition at present. There are cases where we can say, at the first glance, healing is im- possible ; amputation must be resorted to. When a locomotive has run over the knee of an unfortunate railroad hand, when a hand or forearm has been caught in the wheels or rollers of machinery, when a premature explosion in blasting stone has crushed or torn off a limb, or hundred-weights have completely mashed a foot or leg, it is not difficult for the surgeon to decide at once on primary amputation, and usually in such cases the state of the limb is such that the patients also, though with a sad heart, quickly consent to the operation. These are not the difficult cases. And in other cases it may be just as easy to foretell, with considerable certainty, the probability of a favorable cure. For instance, if fracture of the leg from indirect force has fol- lowed too great bending of the bone, the broken pointed end of the crest of the tibia may puncture and force through the skin ; in such a case there is no contusion, but simply a tear through the skin. When a pointed body strikes forcibly against a small portion of a 212 OPEN FRACTURES AND SUPPURATION OF BONE. limb, and injures bone and skin, the whole extremity may be greatly shaken ; but the extent of the injury is not great, and most of such cases terminate favorably under suitable treatment. The question- able cases lie between these two extremes. In cases where there is some contusion, but only a slight amount evident, and the skin is only injured at a small spot, it will be very difficult to decide whether healing should be attempted or amputation be resorted to, and the peculiarity of the individual case alone can settle the question. Of late the tendency is increasing rather to try to preserve the limb in these doubtful cases than to amputate one that might possibly have been saved. This principle is certainly justified on humane grounds ; but it cannot be denied that this conservative surgery may be prac- tised at the cost of life, and that we cannot with impunity vary too much from the principles of the older surgeons, who generally pre- ferred amputation in these doubtful cases. Besides mode of origin of the injury, and the amount of accompanying contusion, the impor- tance in any given case depends on whether we have to deal with deep wounds, with fractured bones lying far down among the muscles, or with bones lying near the skin, as the danger of suppuration de- pends greatly on the depth and extent of the bone-injury. Thus, an open fracture at the anterior part of the leg is of more favorable prognosis than a similar injury of the arm or forearm. Open fractures of the thigh are the most unfavorable ; indeed, some surgeons always amputate for such injuries. Large nerve-trunks are rarely torn in fractures, and, when they are, it does not seem to have much effect on the cure ; and experiments on animals, as well as observations on man, show that bones may unite normally in paralyzed limbs. Injury of large venous trunks, as of the femoral vein, causes haemorrhage, which may be readily checked by a compressing-bandage, it is true, but may prove dangerous when the blood effused between the muscles and under the skin begins to decompose. Rupture of the arterial trunk of a limb occasionally leads at once to considerable arterial haemorrhages ; but this is not a necessary sequence ; for, as previously shown, a thrombus quickly forms in the crushed artery, so that we do not always have extensive haemorrhage. But, if, from the nature of the haemorrhage, we recognize the rupture of an artery, according to principles already laid down, we should either attempt to ligate the artery at the wound, or else at the point of election. Rupture of the femoral artery with fracture of the femur is found by experience to be followed by gangrene, and is an imperative indication for ampu- tation ; in a corresponding injury of the arm, recovery may result or gangrene may follow. In fractures of the forearm or leg, even if one or both arteries be ruptured, recovery may take place. Lastly, PROGNOSIS m OPEN FRACTURES. 213 in the question as to whether we shall try for union, or proceed to amputation, we must consider how useful the limb can be if union results and all unfavorable chances have been overcome. In compli- cated fractures of the foot and lower part of the leg this question may be particularly important, and it has frequently been necessary to amputate a foot because of the change of form and position result- ing after union of an open, comminuted fracture, which rendered it useless for walking. The same thing is to be considered when, in a case of moderately extensive gangrene of the foot, we wish to decide if it should be amputated or not. The dead portion of the foot may be detached in such an inconvenient shape that the remaining stump is neither useful for walking nor for the adaptation of an artificial limb. In such cases we should amputate, for all our methods of am- putating are designed for the future application of artificial limbs. Since the nature of the subject has led us directly to the indica- tions for amputation in injuries, I shall at once proceed to the sub- ject of secondary amputations. In the question as to whether a complicated fracture should be amputated or not, you might readily satisfy yourself with the idea that it might be done at any future time if the fears of an unfavorable course should be realized. On this point attentive observation shows that there are two periods for this secondary amputation. The first danger threatens the patient from an acute decomposition about the wound and the consequent putrid intoxication of the blood. The question as to this danger is settled during the first four days ; if it arises, and you then amputate (this must be done far above the point of putrefaction), it is just at the most unfavorable period for the operation, for you will very rarely succeed in saving your patient. Somewhat more favorable, but still unfavor- able as compared with primary amputations (those made within the first forty-eight hours), are the results of amputations made from the eighth to the fourteenth day ; they are particularly unfavorable if the symptoms of acute purulent infection, pyaemia, are distinctly present. If the patient has survived two or three weeks, and profuse exhaust- ing suppuration or other local indication for amputation arise, the results are again relatively favorable. When some surgeons have asserted that secondary amputations give better results than primary, they have almost exclusively considered these later secondary ampu- tations. But, if we bear in mind how many patients with open frac- tures die during the first three weeks, that is, how few of them live till the favorable time for secondary amputations, it seems to me we can have no doubt about the decided advantages of primary amputations. Up to the present time I have rarely found indications for late second- ary amputations. 214 OPEN FRACTURES AND SUPPURATION OF BONE. An open fracture may unite in various ways. The skin- wound, as well as the deeper parts, occasionally heals by first intention ; this is the most favorable case. Under modern treatment this occurs more fre- quently than formerly, although, from the nature of the case, the re- quirements for this result are not often present. Far more frequently (and this is also favorable) the wound only suppurates superficially, and not between and around the ends of the bone, but union of the bone takes place as in simple subcutaneous fracture. The cases where the wound only affects the skin, and does not communicate with the fracture, should not be counted among complicated fractures ; but the limits are difficult to trace. The process of cure must of course differ greatly from the above, if the skin-wound be large, the soft parts greatly contused, so that fragments are detached from them ; if the suppuration extends deep between the muscles and around the bone, and even into its medullary cavity; if the fragments are bathed in pus; if half-loose pieces of bone lie about, and longitudinal fissures extend into the bone. The activity of the soft parts will remain essentially the same as in subcu- taneous fractures, except that in this case the inflammatory new forma- tion does not directly become callus, but, after detachment of the crushed, necrosed shreds of tissue, granulations and pus are formed, the former of which are transformed to ossifying callus. The form of the callus will not be much changed, except that, where the open suppurating wound exists for a long time, there will be a gap in the callus-ring till it is closed by the after-growth of deep ossifying granu- lations. Hence the process will terminate far more slowly than in subcutaneous fracture, just as healing by suppuration takes longer than healing by first intention. Now, what becomes of the ends of the fragments which, partly or entirely denuded of periosteum, lie in the wound ? What becomes of pieces detached from the bone, and only loosely attached to the soft parts ? As in the soft parts, so here one of two things may happen, according as the ends of the bone are living or dead. In the first and most frequent case, granulations grow directly from the surface of the bone. In the latter, as in the soft parts, plastic activity in the bone occurs on the borders of the living ; interstitial granulations and pus form ; the bone melts away ; the dead end of the bone, the sequestrum, falls off. The extent to which this process of detachment goes natu- rally depends on the extent to which the bone is dead, or, expressed more physiologically, on the extent to which the circulation has ceased from stoppage of the vessels. This extent may vary greatly : it may possibly extend only to the superficial layer of the injured bone : and, since the whole process is called necrosis, this superficial detachment UNION OF OPEN FRACTURES. 215 of a plate of bone is termed necrosis superficialis, while that of the whole fractured end of the bone may be called necrosis totalis • but the latter term is more usual for indicating that the entire diaphysis of a long bone, or at least the greater part of it, is detached, and the opposite of this is necrosis partialis. The opposite of the above- mentioned necrosis superficialis, which is also termed exfoliation, is properly necrosis centralis, that is, detachment of an inner portion of bone. Necrosis superficialis and necrosis of the broken ends and partly-detached fragments of the bone are so often combined with sup- purating fractures, of which we have to treat here, that we must treat of them in this place. It will at first seem strange to you that vascu- lar granulations should spring from the hard, smooth cortical substance of a long bone. From what has already been said, it will seem pos- sible that, under the influence of this plastic process, the hard osseous tissue should be so dissolved that there may be a spontaneous solu- tion of continuity between the dead and healthy bone. We shall now study more exactly these processes of formation of granulations and of suppuration in bone. You will remember, from the full description of traumatic suppu- ration of the soft parts, that in traumatic inflammation the process chiefly depends on free suppuration and extensive formation of new vessels, as well as on direct cell-infiltration from the blood, while the intercellular substance assumes a gelatinous or fluid consistence. Both of these processes can only take place to a slight extent in bone, especially in the firm cortical substance of a long bone, because the firm osseous substance prevents much dilatation of the capillaries which are enclosed in the Haversian canals. I may at once call your attention to the fact that, from this slight distensibility of the vessels in the osseous canals, portions of bone may more readily die than would be the case with the soft parts, because, in case of coagulation of blood, even in the smaller vessels, the nutrition can be only imper- fectly kept up by collateral circulation. Moreover, the connective tissue and the vessels in the Haversian canals may be entirely de- stroyed by suppuration, so that necrosis at the ends of the fragments will be inevitable. Should a vascular granulation-tissue develop on the surface of the bone or in its compact substance, this can only occur as previously described, after the osseous substance (lime-salts as well as organic matter) has disappeared at the point where the new tissue is to appear ; hence there must be solution and atrophy of the bone- tissue, just as there are of the soft parts under similar circumstances (see Fig. 39). The whole difference appears chiefly in the difference of time, for the development of granulations on and in the bone takes much longer than in the soft parts. I have already stated that the 216 OPEN FRACTURES AND SUPPURATION OF BONE. same process requires much longer in the tendons and fasciae, which have few vessels, than in the connective tissue, muscles, and skin ; in the bone it requires even more time than in the tendons. The con- stitutional power of the individual, and the consequent so-called vitality of the tissues, are also to be taken into consideration. LECTURE XYI. Development of Osseous Granulations. — Histology. — Detachment of the Sequestrum. — Histology. — Osseous New Formation around the Detached Sequestrum. — Callus in Suppurating Fractures. — Suppurative Periostitis and Osteomyelitis. — General Con- dition. — Fever. — Treatment ; Fenestrated, Closed, Split Dressings. — Antiphlogistic Remedies. — Immersion.— Rules about Bone-splinters. — After-Treatment. When a denuded portion of bone begins to throw out granula- tions on its surface (which in complicated fractures we can only see when the ends of the fragments are exposed by a large skin-wound, on the interior surface of the leg, for instance), we recognize this with the naked eye by the following changes : For the first eight or ten days after being denuded of periosteum, the bone mostly preserves its pure yellowish color, which, even during the last day of the above period, changes toward bright rose-color. If we then examine the surface of the bone with a lens, we may notice numbers of very fine red points and striae, which a few days later become visible to the naked eye also ; these rapidly increase in size, grow in length and breadth, till they unite and then present a perfect granulating surface which passes immediately into the granulations of the surrounding soft parts, and subsequently participates in the cicatrization, so that such a cicatrix adheres firmly to the bone. If we follow this process in its finer histological details, which must be chiefly done experimentally, by aid of injected bones de- prived of their lime, we have the following result : If the circulation in the bone is maintained near to the surface, there is a rich infiltra- tion of cells into the connective tissue accompanying the vessels in the Haversian canals ; this tissue grows, with the vascular loops de- veloping toward the surface, out of the bone at the points where the Haversian canals open externally. The development of this young granulation-mass laterally results at the expense of reabsorbed bone. If we macerate one of these bones with superficial granulations, its surface will appear gnawed and rough ; in the living bone, granulation tissue fills the numerous small holes, which all communicate with the Haversian canals. The surface of the bone does not, however, remain UNION OF OPEN FRACTURES. 217 in this state, but, while the osseous granulations on the surface con- dense to connective tissue and cicatrize, in the deeper parts they ossify quite rapidly, so that at the termination of the process of heal- ing the surface of the injured bone does not show a deficiency, but appears denser from deposit of new bone. You see that here too the circumstances are exactly the same as in subcutaneous development of the inflammatory neoplasia. If you look at Fig. 49, and suppose the periosteum removed from the surface of the bone, the new formation (in this case as granulations) will grow fungous-like out of the Haver- sian canals. You will understand this better if we now follow more carefully the process of detachment of necrosed portions of bone. Let us re- turn to what we see with the naked eye, and let us suppose we have before us a portion of the parietal bone denuded of soft parts ; then, if no granulations, as above described, grow from the bone, we shall have the following symptoms : While the surrounding soft parts and the portion of bone still covered with periosteum have already pro- duced numerous granulations and secrete pus, the dead portion of bone remains pure white or becomes gray or even blackish. It re- mains some weeks, sometimes two months or more ; most proliferant granulations grow around it ; cicatrization has already begun in the periphery of the wound, and we cannot decide how the case will ter- minate, for in the sixth week the surface of the bone may look just as it did the day after injury. Some day we feel the bone and find it Detachment of a superficial piece of a flat bone (as of one of the cranial bones), which has been ex- posed by an injury and become necrosed. Necrosis superficialis ; a, the granulations arising 1 from the living portion of the bone undermine the dead portion, the sequestrum (shaded vertically) ; &, the lower side of the sequestrum has been considerably eaten away by the granulations, which have perforated it at various points. Diagram, natural size. 218 OPEN FRACTURES AND SUPPURATION OF BONE. movable ; after a few attempts one blade of the forceps may be intro- duced under it and we lift off a thin plate of bone, under which we find luxuriant granulations ; the under surface of this plate is very rough, as if eaten away. Now healing goes on rapidly. It is often long before the cicatrix becomes permanent and solid enough to re- sist all injuries, such as pressure and friction, but healing often termi- nates favorably. This is the process that we term necrosis superfi- cialis or exfoliation of bone. We are already acquainted with this process in the soft parts ; during the first week large shreds of tissue fall from the contused wound, since on the border of the healthy tis- sue there is an interstitial development of granulation, by which the tissue is detached ; the process is the same here. In a bone deprived of its lime we may readily examine these processes anatomically. The inflammatory neoplasia, or granulation tissue, develops on the mar- gin of the healthy bone in the Haversian canals. The accompanying figure (Fig. 55) may represent to you the details of this process. If you have fully understood what has been said, it only requires a slight stretch of imagination to see how the same process of detach- ment of a fragment may extend through the entire thickness of bone ; that is, how (and here we come back to complicated fractures) a vari- able length of the fractured end of a bone may be entirely detached^ when it is incapable of living. When the bone in question is thick, this process requires sev- eral months; but at last we may find even large pieces of bone movable in the wound, and remove them as we would a su- perficial bony plate. As regards splinters entirely detached from the bone, and only attached to the soft parts, their future fate, as regards living or not, depends on how far their circulation is preserved. If they are not capable of living, they at last become entirely detach- ed by suppuration of the soft parts attached to them, and of- ten, as foreign bodies, keep up irritation and suppuration of the wound. If they are capable of living, they produce granula- Diagram of detachment of a necrosed portion of bone. Magnified 300. a, necrosed portion of bone; ft, living bone; c, new formation in the Haversian canals, by which the bone is de- tached. Compare Fig. 36. DETACHMENT OF THE SEQUESTRUM. 219 tions on the free surface ; these subsequently ossify and unite with the other callus, forming around the fractured ends. To represent the relation of the formation of callus to this process of detachment of the necrosed ends of the fractured bone, I present the following figure (Fig. 56). The fragments of the broken bone are not accurately adjusted, but displaced somewhat laterally ; the ends of the fragments have both become necrosed, and nearly detached by interstitial proliferation of granulations on the borders of the living bone. The whole wound is lined with granulations, which secrete pus that escapes at d. In both fragments, an inner callus (b b) has formed, which, however, from suppuration of the fractured surfaces, has not yet been soldered to- gether. The outer callus (c c) is irregular, and interrupted at d, be- cause the pus escapes here from the first. When the granulations grow so strongly as to fill the entire cavity, and subsequently ossify, healing is completed, and the final result is just the same as in the healing of subcutaneous fractures. For this to take place the necrosed portions of bone must be removed, for experience shows they cannot heal up in the osseous cicatrix. This elimination of the sequestrated Fig. 56. Fig. 57. Diagram of fracture of a long bone with external wound, longitudinal section. Natural size, ee, bone; ////, soft parts of the limb ; aaaa, necrosed ends of bone. The darkly-shaded part repre- sents the granulations, which line (d) the wound that opens outwardly, and secrete pus ; bb, internal callus in the two dislocated ends of bone; cc exter nal callus. Amputation stump of the thigh, with necro- sis of the sawed sur- face. 220 OPEN FRACTURES AND SUPPURATION OF BONE. fragments takes place either by reabsorption or by artificial removal outwardly ; the former is the more frequent in small, the latter in large sequestra ; but union will not result as long as the sequestrum remains between the granulations of the fragments. Since the open- ing at d may be much contracted by the development of external callus, the operative removal of the necrosed ends is often very diffi- cult. We find, by examination with the probe, whether such seques- tra in the deeper parts really existed, and if they are detached. If you suppose the sequestrum, a a (Fig. 56), removed from the wound, there is no obstacle to the filling of the wound with granulations and to their subsequent ossification. Such sequestra in complicated frac- tures are frequently the cause, not only of new exacerbations of the acute suppurative inflammation, but also of subacute and chronic peri- ostitis, with protracted firm oedema of the extremity and annoying eczematous eruptions on the skin, as well as of long-continued bone fistulae and ulcerations of the ends of the fragment. The action of this sequestrum combines the double effect of a foreign body and that of local or general purulent infection. We may speak here of conditions as they exist in the bone after amputation. Imagine Fig. 56 divided transversely at the point of fracture and the lower half removed, then the condition will be just the same as after amputation. Granulations either grow directly from the wounded surface, or a portion (the sawed surface) is necrosed to a greater or less extent (Fig. 57). Let this be as it may, in the medullary cavity, as well as on the outside of the bone, a neoplasia (a half callus) is formed ; this subsequently ossifies ; if you examine an amputation stump several months old, you will find the medullary space in the stump of the bone closed by osseous deposits, as well as external thickening of the bone. We may here remark that the name callus is used almost exclusively for the bony new formation in frac- tures, while the young bony formations on the outside occurring in various ways are called " osteophytes " (from dareov, bone, and (pyfia, tumor) ; callus and osteophytes are not then very different, but both are designations for young osseous formations. In considering the process of suppuration, we have left out of con- sideration two of the constituents of bone, namely, the periosteum and medulla. In observing the development of callus, we saw that the periosteum also had something to do with the formation of new bone. But, if, in open suppurating fractures, the suppurative inflammation spreads greatly as a result of extensive contusion, a large amount of SUPPURATIVE PERIOSTITIS. 221 periosteum may necrose or suppurate, and in such cases we find wide-spread suppurative periostitis / the greater part of a long bone, as the tibia, may be bathed in pus. The bone thus losing its connec- tion with the soft parts, its supply of blood is withdrawn, and from this cause there may be extensive necrosis of the bone as a result of suppurative periostitis. But these local dangers are slight in com- parison to the dangers to the organism at large from these deep sup- purations ; we shall hereafter treat fully of these. In the same way the medulla either of a long or spongy bone may participate in the suppuration. From what has already been said, you know that, in the course of the normal union of fracture, new bone- tissue forms in the medullary cavity, and closes it for some time. In open, suppurating fractures there is also occasionally suppuration of the medulla, that may extend more or less. Such a suppurative os- teomyelitis is quite as dangerous, both for the life of the bone and for the entire organism, as suppurative periostitis. From various causes, too, it may asssume a putrid character ; the larger veins of the bone, that come from the medulla, may participate in the suppuration, and this disease is the more destructive because of its deep situation ; it is often first recognized at the autopsy. Purulent osteomyelitis alone may also lead to partial and even to total necrosis of a bone, the more so when combined with suppurative periostitis. Although it was necessary to make you acquainted with all the above local complications of open fractures, I may say for your relief that they rarely occur so extensively as above described ; neither total necrosis of both ends of the fracture, nor extensive purulent perios- titis and osteomyelitis are frequent results of these fractures ; but, for- tunately, healing of the deeper parts often takes place very simply, and suppuration only continues externally. Whether a traumatic inflammation leading to suppuration shall extend beyond the borders of the irritation (of the injury) depends, as in simple contused wounds, on the grade of the local infection by mortifying tissue in the wound, and later on all the circumstances that we have learned as direct or indirect causes of secondary in- flammation of wounds. The greater the shattering of the bone (espe- cially in gunshot- wounds), the greater are all mediate and immediate results of the injury. Now a few words about the general condition of the patient, espe- cially as to fever. While in subcutaneous fractures it is to be regarded as a rarity for a patient to have fever, the reverse is true in open frac- ture. If ever the fever evidently depends on the extent and intensity of the local process, it does so here. As we have already mentioned, in con- tused wounds, every extension of the inflammation is accompanied by 222 OPEN FRACTURES AND SUPPURATION OF BONE. an increase of fever, and, generally speaking, this is the more decided the deeper the suppuration. In accidental osteomyelitis and perios- titis the evening temperature of the body not unfrequently rises above one hundred and four degrees Fahrenheit ; rapid elevation of tem- perature with chills is, unfortunately, a frequent symptom ; septicaemia and pyemia, trismus, and delirium potatorum, are especially apt to accompany suppurating fractures, so that I can only repeat here, what I said at the beginning of the chapter, that any open fracture may be or may become a severe and dangerous injury. Hence, the greatest circumspection and care are necessary. I can tell you, from my own experience, that the most successful operation never gave me such pleasure as the successful union of a severe complicated fracture. Let us now pass to the treatment of open fractures. After the advantages of firm dressings had become apparent, it was natural to try them in modified forms in open fractures ; indeed, some time since, jSeutin, the inventor of the starch-bandage, used the so-called fenes- trated bandage, i. e., in the firm starch-bandage he made an opening corresponding to the wound in the soft parts, so as to leave the latter open to observation during treatment. The primitive forms of these fenestrated starch and plaster bandages also, which are now often used, had great objections, that may now be considered as overcome. The chief objection to the fenestrated bandage was that the under-band- age and the wadding were readily saturated with pus, which decom- posed and became offensive. Extensive experience has shown me that these objections may be overcome ; it is only necessary to make the openings large enough, to round off the edges with strips of muslin attached by plaster, to make the dressing firm by means of His's position-splints, by introducing strips of wood, etc., and to catch the secretion from the wound in basins placed beneath. If this dress- ing remain firm and clean, the trouble of its first application is well repaid, not only by the brilliant success of this mode of treat- ment, but also by the great saving of time in the subsequent care of the wound. For some time I employed plaster-bandages in open fractures in this way : at first I applied them closed, just as in simple fractures, and soon slit them up lengthwise, opened them, and dressed the wound every day or two as required, without moving the frag- ments, and continued this till the wound was healed, then applied a new closed bandage. This method is good for some cases, and shows some good results. The essential thing in these dressings is that, after deciding not to amputate, even the most complicated fractures should be placed in the plaster-dressing immediately after the injury, just as in the case of simple fracture, only with the difference that the wound should first be covered with charpie or compresses previ- ously dipped in lead-water or solution of chloride of lime, and that TREATMENT OF OPEN FRACTURES. 223 quantities of wadding (two finger-breadths thick) should be laid on the limb before the dressing is applied, so that, even if there should be swelling, the limb may not be strangulated by the dressing. The difficulty of applying any firm dressing is increased by the presence of a large wound or of several wounds at the same time. Should there be extensive and deep suppuration in such cases, so that numerous counter-openings must be made, and the number of the wounds thus increased, it will be impossible to keep the same dress- ing long, and we may then be obliged temporarily to return to splints and fracture-boxes, which must be completely renewed every day. Moreover, as you may gather from what has been said, these severe cases often stand on the borders of amputation, i. e., their union is very problematical. The more practice one has in the application of the plaster-dressing, the more rarely will bad accidents happen. Since I have applied the dressing in the above manner to complicated fractures, I see diffuse septic inflammations and secondary suppura- tions much more rarely. I am convinced that the treatment of open fractures by plaster-dressings is the best ; but this method must be studied, we must not suppose we know it a priori. Should a surgeon of the old school see our present treatment of fractures, simple as well as complicated, he would consider it not only irrational but foolhardy, for formerly fractures, like all other injuries, were treated first by antiphlogistics, every thing else being secondary. Hence it was considered necessary to apply leeches to the limb in the vicinity of the fracture, to keep on cold compresses or bladders of ice, and to purge the patient freely. Subsequently, when suppuration from the open fracture began, they usually resorted to cataplasms, which were continued till healing was almost completed. Besides this, splints were applied and changed about every two or three days, according as the wound was dressed more or less frequently on ac- count of the suppuration. Larrey was one of the first to speak against this frequent change of dressings in wounds, especially in open fractures ; if we may trust his notes, he carried this idea to an unjus- tifiable extent, for he did not always remove the dressings even when quantities of maggots had developed under them. Of late, the gen- eral opinion is that, in the treatment of open as well as of simple frac- tures, the accurate fixation of the fragments is the first requirement for favorable union, and that nothing is more apt to excite inflammation around the wound than movement of the fragments. Hence a firm dressing is the most important and efficacious antiphlogistic that we can use. We here repeat a previous remark, that cold and abstrac- tion of blood have no prophylactic and antiphlogistic action, as was for- merly supposed. If, on account of commencing progressive inflamma- 224 OPEN FRACTURES AND SUPPURATION OF BONE. fcion around the wound, I consider it necessary to apply ice, I remove a piece from the plaster-dressing, corresponding to the point where the ice-bladder is to be applied. In case of suppuration about the wound, openings are to be made for the escape of pus. The general principles as to the choice of the point for the opening is to make the counter-opening where fluctuation is most distinct, and where the soft parts are thinnest, where the pus will escape most readily without pressure from the finger. If we have to cut openings in the bandage, this may be done most easily two or three hours after its application. After making openings in the plaster-bandage corresponding to the wound, without disturbing the limb, we separate the wadding, remove the charpie, and bind the opening carefully ; then with a spatula we introduce wadding under the edges of the opening to prevent the secretion from the wound getting under the dressing. For more than a year I have been leaving these wounds open also, and have been astonished at the success of this method of treatment. In the treatment of complicated fractures with plaster-dressings, very care* ful manipulation and the knowledge of a large number of details which can only be acquired at the bedside of the patient, are neces- sary ; the gift of inventing modifications of various forms of dressing is also necessary. The treatment of open fractures is often very diffi- cult ; every one employs in practice the method he has learned ; it makes little difference whether we employ plaster, starch, or liquid- glass dressings; the essential thing is for the fragments to lie quiet and firm, and not to be moved by the dressings, then the patient will recover well and without pain. The favorable experience of immer- sion in contused wounds of the hand and foot has induced some sur- geons to treat complicated fractures, of the leg and forearm at least, in the same way. In the Berlin surgical clinic they have tried keep- ing the fractured limb dressed with a fenestrated plaster-bandage, in a permanent water-bath ; for this purpose the plaster must be made water-tight with cement, solution of shellac, liquid glass, collodium, or something of that sort. The results of this treatment are celebrated. But, should any suppurative inflammation occur about the wound, in which the water-bath is injurious, this method would appear to me less suitable than any other. In the treatment of open fractures with splints, we generally use straight, narrow wooden splints ; in the lower extremity these are pro- vided with a suitable foot-piece. As we commenced speaking of the treatment of complicated frac- tures by describing the dressings, I must add a few words about the first examination. The diagnosis of complicated fractures is made like that of simple fractures. Passing the fingers into the wound is TREATMENT OF OPEN FRACTURES. 225 usually unnecessary and injurious ; we should only draw out splinters of bone when we think we feel or see them entirely loose ; the less you examine the wound the better. We leave all adherent splinters of bone ; sawing off pointed ends of fragments (primary resection of the fragments) I consider unnecessary and generally injurious ; I have only done it when, even under chloroform, they projected so that it was impossible to replace and keep them in position. The reposition of the fragments should be accurately made before the application of the dressing ; subsequent bending and traction should be decidedly avoided, and, if it should be necessary on account of great dislocation, should be postponed till healing of the wound. In the same way early traction on half-detached splinters of bone is entirely inappro- priate and useless ; a piece of dead bone adherent to the periosteum or other soft parts is gradually detached spontaneously, and may then be removed. We should not examine till quite late, when the wound is fistulous, to see if fragments situated deeply are necrosed, and should then do it very carefully and with very clean instruments. If there be extensive necrosis of one or both fractured ends, their ex- traction may be very difficult ; we then resort to the same operations as for necrosis from any cause ; we shall speak of this when treating of diseases of the bones, but this should not be done till the process has become chronic. The union of complicated fractures always requires longer than in simple fractures ; indeed, in protracted suppurations it may take double the time. We have to decide this by manual examination, and not allow the patient to attempt walking till the fracture is perfectly con- solidated. The disappearance of the callus, its condensation, its atro- phy externally and its reabsorption till the medullary cavity is re- stored, go on just as in simple subcutaneous fractures. The treat- ment of complicated fractures is one of the most difficult things in surgery ; we never cease learning on this point. 15 APPENDIX TO CHAPTERS V. AND VI. LECTURE XVII. 1. Eetarded Formation of Callus and Development of Pseudarthrosis. — Causes often unknown. — Local Causes. — Constitutional Causes. — Anatomical Conditions. — Treatment: internal, operative; Criticism of Methods. 2. Obliquely-united Fractures ; Eebreaking, Bloody Operations. — Abnormal Development of Callus. 1.— EETAEDED DEVELOPMENT OF CALLUS AND FOEMATION OF A SO- CALLED FALSE JOINT— A SO-CALLED PSEUDAETHEOSIS. Under some circumstances, which we do not always sufficiently understand, a fracture is not consolidated after the lapse of the usual time ; indeed, it may not consolidate at all, but the seat of fracture may remain painless and movable, which of course impairs the func- tion of the limb, even to the point of entire uselessness. A short time since, a strong farmer-boy, with simple subcutaneous fracture of the leg without dislocation, entered the hospital ; as usual, a plaster- bandage was applied and renewed in fourteen days. Six weeks after the fracture the dressing was removed altogether, in the expectation that union had taken place ; but the point of fracture was still per- fectly movable, nor could any callus be felt. I here tried the sim- plest remedy in such cases, I narcotized the patient, and then rubbed the fragments strongly together till crepitation could be distinctly perceived ; then I applied another plaster-dressing, and on removing this in four weeks found the fracture tolerably firm. I placed the pa- tient in a fracture-box, and, without placing any bandage on the leg, had its anterior surface painted daily with strong tincture of iodine. After this had been continued a fortnight, the fracture was perfectly firm ; the patient now stood with the aid of crutches, and in a short time was dismissed cured. I know of two other cases from the prac- tice of colleagues, where simple fractures in very healthy young per- sons did not consolidate, but formed pseudarthroses. Such occur- rences are to be regarded as very rare ; usually there is some peculiar PSEUDARTHROSIS. 227 cause, such as disease of the bone, that induces false joint. There are certain fractures of the human skeleton which from various causes very rarely unite by bony callus ; among these, are intracapsular frac- tures of the neck of the femur, neck of the humerus, and fractures of the olecranon and patella. When fractured transversely the two latter bones separate so far that the osseous substance formed on the two ends cannot meet, so that only a ligamentous union can take place be- tween these two parts of bone. When fractured within the capsule the head of the femur has, it is true, a supply of blood through a small artery which enters it through the ligamentum teres, but this source of nutrition is very slight, consequently the production of bone from the small fragments is slight. In fracture of the head of the humerus within the capsule, in the rare case of part of the head be- ing entirely detached from the rest of the bone, this portion of bone will receive no supply of blood, and will act as a foreign body ; its union can scarcely be expected. In the above examples, we regard non-union so much as the rule that we do not usually call them cases of pseudarthrosis. But I wish to show you that there may be purely local causes that predispose to pseudarthrosis; among these espe- cially belongs complete loss of large pieces of bone, after the removal of which, in open fractures, there may be so large a defect that it will not be again filled by new bone-tissue. Protracted suppuration with ulcerative destruction, and extensive detachment of the ends of the fragments, may also lead to pseudarthrosis. Moreover, the treatment is occasionally blamed ; too loose a dressing, or none at all, and too early motion, are occasionally accused. On the other hand, it has been asserted that too continued application of cold, the simultaneous ligation of large arteries, and, lastly, too tight a dressing, may inter- fere with proper development of bony callus. All this alone does not necessarily lead to pseudarthrosis, but may act as a second cause when the general conditions of nutrition in the organism predispose to it. Of the general predispositions and bone diseases, the following may be mentioned as disposing to pseudarthrosis : bad nutrition, debility from repeated losses of blood, specific diseases of the blood, such as scorbutis, or cancerous cachexia. Of the diseases of the bones, it is chiefly osteomalacia, atrophy of the cortical substance, with enlarge- ment of the medullary cavity, in which, as already mentioned, in certain stages there is not only decided fragilitas ossium, but in which also the chances for reunion are slight. I have stated all this, because it is gen- erally accepted, although, on sharp critical examination, some of the above-mentioned predisposing causes for pseudarthrosis are of very different value, while the significance of others is entirely doubtful. In the same way it is a common belief that fractures are not consoK- 228 APPENDIX TO CHAPTERS V. AND VI. dated in pregnant females. This is not true in all cases ; I have my- self seen numerous fractures unite in pregnant women, only once hardening of the callus was delayed a few weeks in a fracture of the lower end of the radius, which was recognized late, as might also occur in women not pregnant, or in men. The abnormity of the healing process in case of pseudarthrosis is not due to the non-formation of callus, but to the failure of ossifica- tion in the new formation. The substance connecting the fragments becomes a more or less rigid connective tissue, by which the ends of the bone are held more or less closely together. If the fragments lie so close that they come in contact on motion of the limb, a cavity with smooth walls, filled with sero-mucous fluid, forms between them in the uniting tissue ; and, on the fractured ends, cartilage has been found, so that there was, in fact, a sort of new joint. This does not, however, occur very often, but in most cases we have simply a firm connecting mass, which sinks directly into the fragments like a tendon. When such a pseudarthrosis is in a small bone, such as the clavicle, or one of the bones of the forearm, the disturbance of func- tion is always bearable ; but, if it be located in the arm, thigh, or leg, of course there must be considerable impairment of function. In some cases it is possible, by suitable supporting apparatus, to give the limb the necessary firmness ; in other cases we cannot do this at all, or only incompletely, so that for a long time attempts have been made to cure this disease by operation, that is, by inducing ossifica- tion. Before passing to the methods used for this purpose, we must mention the attempts made to prevent false joint, and to cure it, when once established, by internal remedies. Preparations of lime are chiefly used for this purpose. Phosphate of lime was given internally in the shape of powder ; lime-water was given in milk, but without much benefit. Of the lime given in this way, little is absorbed, and, of this superfluous lime taken into the blood, much was excreted through the kidneys, so that the pseudarthrosis had little good from it. We may expect more from general regulation of diet, and pre- scribing articles of food that contain lime. Residence in pure country air, and milk-diet, are to be recommended ; but you must not expect too much from these remedies, especially in a fully-formed false joint that has existed for years. In a recently-published and very interest- ing work by Wegner, it is shown, by a number of experiments, that by continued administration of small doses of phosphorus the forma- tion cf callus about fractures is particularly luxurious and hard, as well as that in growing animals the portion of bone formed during the ad- ministration of phosphorus is unusually dense and hard, and very rich in chalky salts. These experiments would lead us to try phos- PSEUDARTHROSIS. 229 phorus in patients with pseudarthrosis, especially in the earlier stages ; of course, we should be very careful of this remedy, which may be so dangerous when carelessly used. The local remedies all aim at inducing inflammation in the ends of the bone and parts around, because experience shows that most inflammations in the bone, especially subcutaneous traumatic ones, induce formation of bone in their immediate vicinity. The remedies employed vary very greatly. We have already mentioned the proposals to leave the limb without dressing, so as to avoid interfering with the formation of the external callus by pressure, also the rubbing together of the fragments, and painting with iodine ; with the same view (viz., of irritating the fragments), we may apply blisters and the hot iron to the part of the limb corresponding to the fracture. By the following remedies we act more on the intermediate ligamentous tissue : long, thin acupuncture-needles are passed into the ligamentous band, and left there for a few days to excite irritation ; we may connect the ends of two of these needles with the poles of a galvanic battery, and pass an electrical current as an irritant. This proceeding is called elec- tro-puncture y it is little used. "We may also pass a thin, small tape, or several threads of silk (a so-called seton or a strong ligature), through the ligamentous tissue, and leave it there till there is free suppuration around it. The following operations attack the bone more directly ; they are quite numerous : For instance, a narrow but strong knife is passed as deep as the fracture, and the ligamentous tissue is shaved first from the end of one fragment, then from the ether, without en- larging the skin-wound. This is called the subcutaneous bloody fresh- ening of the fragments. Or we may make an incision down to the bone, dissect out the two fragments, perforate them close to the fract- ured end, and pass a sufficiently thick lead wire through the perfora- tions, twist the ends together, so as to approximate the fragments, or else, after making an incision, we may saw off a thin piece from each fragment, and treat the resulting wound like an open fracture ; and to this operatioo, resection of the fragments, we may add the application of a suture of the bone. The following operation originates with Dief- fenbach : Corresponding to the ends of the fragments he makes two small incisions down to the bone, then he perforates the ends of the bone close to its borders, and with a hammer drives ivory pegs, of suitable thickness, into the perforations. The consequence is, a for- mation around these foreign bodies of new bone, which, when ex- tensive enough, as it may always be made in the course of time by repeating the operation, causes firm union. I will here mention that, when extracted in a few weeks, these ivory pegs look rough and 230 APPENDIX TO CHAPTERS V. AND VI. corroded at the points where they were in contact with the bone, while the perforation in which they lay is mostly filled with granula- tions ; occasionally the pegs are not removed ; the openings through which they were introduced heal. This proves absolutely that dead bone, among which ivory is to be classed, may be dissolved and reab- sorbed by the growing osseous granulations. We shall hereafter have frequent occasion to return to this much-contested question, which is very important in some bone-diseases ; we have already spoken of the theoretical causes of this reabsorption (p. 197). B. v. Langen- beck has modified this operation of Dieffenbach by using metal screws instead of ivory pegs; immediately after the operation he fastens these screws to an apparatus, which keeps the fragments im- movable. After all these operations, a suitable dressing must be applied to keep the fragments firm. The modes of operation in pseudarthrosis, of which I have only mentioned the principal ones, are, as you see, quite numerous; and, if the results of treatment corresponded to the number of remedies, this would belong to the most curable class of diseases. But in medicine you may generally take it that, with the increase in number of reme- dies for a disease, their value decreases. Easy and certain as some forms of pseudarthosis are to cure, others are just as difficult ; nor are all the different methods suited to the same case. In the first place, the operations vary greatly as to danger, being much more dangerous in limbs with thick soft parts, especially in the thigh, than in others ; and, as may be readily supposed, the non-bloody operations are less dangerous than the bloody ; those made with a small wound less so than those with larger. As regards efficacy and certainty, I consider the introduction of a bone suture and resection as those which, even in the worst cases, give proportionately the quickest results, but which still have all the elements of danger of a fracture complicated by a wound. The treatment with ivory pegs is less dangerous, ex- cept in the thigh, where every false joint is dangerous, and I think it would accomplish the object in most cases, if the operation were repeated often enough. I have seen good results from this treat- ment, and from Von LangenbecJc's screw apparatus, as well as from the bone suture. In pseudarthrosis of the thigh the question may seriously be asked, if we should not prefer amputation at the point of the false joint (which is of favorable prognosis) to any other dangerous or doubtful operation. This question only the peculiarities of the in- dividual case can decide. In some cases the safe aid of a suitable splint apparatus, made by a skilful instrument-maker, is preferable to any operation. OBLIQUELY-UNITED FRACTURES. 231 2.— OBLIQUELY-UNITED FRACTURES. Although, with the progress made in the treatment of fractures, it is now rare for union to occur in so oblique a direction as to render the limb entirely useless, still, cases from time to time arise where, in spite of the greatest care of the surgeon, in fractures with open wounds, dislocation cannot be avoided, or else, from carelessness or great restlessness of the patient and loose application of the dress- ings, a considerable obliquity in the position of the fracture remains. In many cases this is so slight that the patients do not care to get rid of the deformity; improvement of the position would only be desired in cases where, from considerable obliquity or shortening of a foot or leg, the movements are decidedly impaired. There are vari- ous means by which we may greatly improve or entirely get rid of these deformities. If, during the process of union, we notice that the fragments are not exactly coapted, we may undertake the adjustment at any time in simple subcutaneous fractures. If, in an open fracture, obliquity of the fragments has taken place under the first dressing, I strongly urge you not to try to rectify it before the wound has healed ; you would thus break up the deeper granulations, and the severest inflammation might again be excited. In fractures that have long suppurated, the callus long remains soft, so that you may always sub- sequently accomplish a gradual improvement in position by properly padding the splints first in one place, then in another, or perhaps by continued extension with weights. If the fracture be fully consoli- dated in an oblique position, we have the following remedies for its improvement : 1; Correction by bending the callus, by infraction ; for this pur- pose we anaesthetize the patient, and with the hands attempt to bend the limb at the point of fracture ; if we succeed in so doing, we apply a firm dressing with the limb in the improved position. This method, so free from danger, can only be successful while the callus is still soft enough to be bent ; hence it can only be done soon after the fracture. 2. Complete breaking up of the ossified callus. This also may sometimes be done by the hands alone, but frequently other mechan- ical means will have to be resorted to. For this purpose various ap- paratuses have been constructed, such as lever and screw machines of considerable power ; one of the most terrible bears the name of " dys- morphosteopalinklastes." All these apparatuses should only be used with the greatest care, so as not to cause too much bruising and con- sequent necrosis of the skin at the point where the machine is applied on which the limb rests. For the not unfrequent obliquely-united fractures of the thigh, the forced extension of A. Wagner (by the 232 APPENDIX TO CHAPTERS V. AND VI. apparatus of Schneider and Menel, which we also employ for reduc- ing old dislocations) has been resorted to with success. The follow- ing illustration will fully explain the mechanical effect of this exten- sion : If you have a bent rod, and let a strong man take hold of each end and draw, the rod will break at the point where it is bent most. If a new fracture of the thigh has been caused by indirect force at the bent part, and the fragments be adjusted in a straight position, you apply a plaster-dressing at once while the limb is still held in the ma- chine. As far as our present experience goes, this method appears to be entirely free from danger, but only suited for the thigh ; in a case of very angular union of a fracture of the leg, where I advised this treatment, the break caused by the extension was not in the old seat of fracture, but near it. 3. The bloody operations on the bone, of which there are two in use, are more dangerous ; the first of these is the subcutaneous oste- otomy of B. v. Langenbeck. This consists in making a small incis- ion down to the bone at the bent part, introducing a medium-sized gimlet through this opening and perforating the bone, without, how- ever, piercing the soft parts on the opposite side ; then draw out the perforator, and pass a small, fine saw through the perforation, and saw the bone transversely, first to one side, then to the other, till you can break the rest of the bone with your hand ; now the bone is to be straightened and the injury treated as a complicated fracture. This operation has only been done on the leg, but, so far as I know, always with good result. It may also be done by not making the adjust- ment till suppuration begins, and the callus has thus been softened and partly reabsorbed. For V, LangenbecJc's instruments we may advantageously substitute fine chisels, as recommended by Gross, for dividing the callus from a small exposed portion of the bone. 4. Lastly, we may employ the method of Mhea Barton, which consists in exposing the bone by a large incision through the skin at the point of curvature, and sawing out a wedge-shaped piece in such a way that the broad part of the wedge shall correspond to the con- vexity, the point to the concavity of the abnormal curvature of the bone. This method also shows good results. On the whole, the non-bloody are to be preferred to the bloody methods, if they do not cause too much contusion ; but the latter are less dangerous than breaking up fractures with strongly-contusing apparatuses. If the deformity, especially of a foot, be so great, in different directions, that none of the above methods offer much prospect of cure, we may have to resort to amputation in some cases. OPERATIONS FOR PSEUDARTHROSIS. 233 In some few cases the callus is abnormally thick and extensive, just as happens in cicatrices of the skin and nerves. Do not be too hasty about operating in such cases, for slow subsequent reabsorption usually takes place in every callus. The removal of such callus masses could only be effected with chisel or saw, and I should be unwilling to decide on such an operation. CHAPTER VII. INJURIES OF THE JOINTS. Contusion. — Distortion. — Opening of the Joint, and Acute Traumatic Articular Inflam- mation. — Variety of Course, and Kesults. — Treatment. — Anatomical Changes. Hitherto we have studied injuries of simple tissue-elements; now we must occupy ourselves with more complicated apparatuses. As is well known, the joints are composed of two ends of bones covered with cartilage ; of a sac frequently containing many appen- dages, pockets, and bulgings ; the synovial membrane, which is classed among the serous membranes ; and of the fibrous capsule of the joint with its strengthening ligaments. Under some circumstances, all these parts participate in the diseases of the joint, so that at the same time we may have disease of a serous membrane, of a fibrous capsule, as well as of cartilage and bone. The participation of these different parts varies exceedingly in intensity and extent ; but I may state at once that the synovial membrane plays the most important part, and that the peculiarity of joint-diseases is chiefly due to the closed and irregular form of the synovial sac. First, a few words about crushing and contusion of the joint. If one receives a heavy blow against the joint, it may swell moderately ; but in most cases, after a few days of rest and applications of lead- water or simple cold water, the swelling and pain subside, and the functions of the joint are restored. In other cases, slight pain and stiffness remain ; a chronic inflammation develops, which may lead to serious disease, of which we cannot at present speak more fully. If we have a chance to examine a moderately-contused joint, the patient having died perhaps of a serious injury received at the same time, we shall find extravasations of blood in the synovial membrane, and even blood in the cavity of the joint itself; in these contusions without fracture the effusions of blood are rarely so extensive that the joint is tensely filled with blood; but this may occur. This condition is called hcemarthron (from al\m, blood, and apdpov, joint). If a joint that has swollen greatly just after an injury remains painful for some OPENINGS OF THE JOINTS. 235 time, and feels hot, a somewhat more active antiphlogistic treatment is indicated. This consists in the application of leeches, regular en- velopment of the joint in wet bandages, causing moderate compres- sion, and in applying an ice-bladder to the joint. As a rule, inflam- mation of this grade may be readily relieved, although chronic dis- eases and a certain irritability of the joint that has been injured not unfrequently follow. It is very important to determine whether the crushing of the joint be accompanied by fracture or fissure of the end of the bone, in which case, it would be necessary to apply a plaster- dressing, and give a guarded prognosis as to the future usefulness of the joint. If the continued application of cold increases the pain, make inunctions of mercurial ointment, and apply moist, warm com- presses covered with gutta-percha and wadding. A form of injury peculiar to joints is distortion (literally, twist- ing). This is an injury that occurs especially often in the foot, and which is commonly called " turning the foot." Such a distortion, which is possible in almost any joint, consists essentially in a tension, too great stretching and even partial rupture, of the capsular liga- ments, with escape of some blood into the joint and surrounding tis- sue. The injury may be very painful at the time, and its consequences are not unfrequently tedious, especially if the treatment be not rightly conducted. Usually abstraction of blood and cold are resorted to in these cases also, but with only temporary benefit. It is much more important to keep the joint perfectly motionless after such in- juries, so that, if any of the ligaments be ruptured, they may heal and acquire their previous firmness. The simplest way of attaining this object is by applying a firm dressing, such as the plaster-bandage, with which we may permit the patient to go about, if it gives him no pain. After ten, twelve, or fourteen days, according to the severity of the injury, we may remove the dressing, but renew it at once if the patient has pain on walking. It may sometimes be necessary to wear this dressing three or four weeks. This appears a long time for such an injury ; but I can assure you that, without the application of a firm dressing, the consequences of these sprains often continue for months, at the same time the danger of subsequent chronic inflammation of the joint is increased. Hence you must not promise too speedy a cure, and must always treat these, often apparently insignificant injuries, conscientiously and carefully. 8 OPENINGS OF THE JOINTS, AND ACUTE TRAUMATIC ARTICULAR INFLAMMATIONS. In now passing to wounds of the joint, we make an immense spring as regards the importance of the injury. While a contusion 236 INJURIES OF THE JOINTS. and sprain of the joint are scarcely noticed by many patients, the open- ing of a synovial sac, with escape of synovia, even if the wound be not large, always has a serious effect on the function of the joint, and is not unfrequently dangerous to life. Here, again, we have the differ- ence between subcutaneous traumatic inflammations and those which open outwardly, of which we spoke when on the subject of con- tusions, and which we also saw in subcutaneous and open fractures. Moreover, in the joints, we have closed irregularly-shaped sacs, in which the pus, once formed, remains, and, besides inflammation of the serous membranes, may result in very tedious processes, but in its acute state often has a bad effect on the general health of the patient. I think the quickest way to describe the process will be to give you a few examples. "We are here speaking only of simple punctured, incised, or cut wounds, without complications from sprains or frac- tures, and choose as our example the knee-joint ; at the same time we must remark that injuries of this joint are regarded as the most se- vere. A man comes to you, who, in cutting wood, has received a wound half an inch long, near the patella, and which has bled but little. This may have happened some hours before, or even the pre- vious day. The patient pays little attention to the wound, and only asks your advice about a proper dressing. You inspect the wound, find that from its position it corresponds to the knee-joint, and around it you may perhaps see some serous, thin, mucous, clear fluid, which escapes in greater quantities when the joint is moved. This will call your attention particularly to the injury ; you examine the patient, and learn from him that, immediately after the injury, there was not much bleeding, but a fluid like white of egg escaped. In such cases you may be certain that the joint has been opened, otherwise the synovia could not have escaped. In small joints the escape of synovia is so slight as to be scarcely noticeable, hence, in injuries of the finger-joint, and even of the ankle, elbow, and wrist, it may for a time be doubtful whether the wound has penetrated the joint or not. When a penetrating wound of the joint is certain, the following rules should at once be pursued : The patient should keep quiet in bed, the wound should be united as quickly as possible, to prevent the es- cape of more synovia, which would interfere with healing of the wound by first intention ; hence we close the skin-wound, if it has a tendency to gape. This may best be done by sutures accurately applied ; in some small wounds, carefully-applied adhesive plaster, or ichthyo- colla-plaster, painted with collodion, may suffice. Now the joint is to be kept absolutely quiet ; this can only be done by firmly bandaging the limb, from below, with wet bandages. In the case before us, the whole leg should be kept securely and firmly extended on a hoi- OPENINGS OF THE JOINTS. 237 low splint, or between two sacs of sand. If, besides this, you give some internal remedy, such as a mild purgative, I think enough has been done for the time. In most text-books on surgery, it is true, you will find the advice to put on a number of leeches, and to keep a bladder of ice constantly applied, to prevent too much inflammation. But I can assure you that local abstraction of blood and cold do not even here have this prophylactic, antiphlogistic action, and that it is time enough to resort to ice in a later stage, although I will not blame any one for using ice from the first in inflammation of the joint. The above dressing I have of late replaced by the plaster-dressing ; I apply it as for a fracture of the knee-joint, from the foot to above the mid- dle of the thigh, with a position-splint, then cut an opening corre- sponding to the anterior surface of the knee and the wound ; the results of this treatment, as compared to the old regular antiphlogistic treat- ment, are very brilliant. Let us return to our patient. You will find that, on the third or fourth day, he will complain somewhat of burning pain in the joint, and be slightly feverish ; on applying your hand, the joint feels warmer than the healthy one. When you have re- moved the sutures, on the fifth or sixth day, in the following two days the course may be in one of two very different directions. Let us first take the favorable case, which is frequent under early treatment with firm dressings ; the wound will heal entirely by first intention, the slight swelling and pain in the joint will diminish during the fol- lowing days, and finally disappear entirely. If you remove the dress- ing in from four to six weeks, the joint will be again movable ; the recovery is complete. But in other cases, especially where the patient comes under treatment late, things turn out worse. Toward the end of the first week there are not only great swelling and heat in the joint, but there is oedema of the leg ; the patient has severe pain on being touched, as well as on every attempt at motion ; toward evening he has high fever, he loses his appetite, and begins to emaciate. At this time the wound may be closed, or a sero-mucous and subsequently purulent fluid escapes from it. But even if this be not the case, the above symp- toms, especially the swelling of the joint, with distinct fluctuation, the pain, increased temperature, oedema of the leg, the increase of fever, point to an acute, intense inflammation of the joint. If in such cases the limb be not fixed, it gradually assumes a flexed position, which in the knee-joint may increase to an acute angle. It is not easy to give the reason for this flexed position of inflamed joints ; it seems to me most probable that it arises, in a reflex manner, by a transfer of the irritation of the sensible nerves of the inflamed synovia to the motor nerves of the flexor muscles. Another explanation is, that every 238 INJURIES OF THE JOINTS. joint may contain more fluid in the flexed than in the extended posi- tion, which has been proved experimentally by Bonnet, who usually brought the joints in the cadaver to a flexed position, by injecting fluid into them. But these experiments do not seem to me to prove any thing about the above-mentioned flexed position, for these also occur in articular inflammations where there is no fluid in the joint ; on the other hand, they are often absent where there is a great deal of fluid. Observation shows that acute painful synovitis most disposes to flexion of the joint. If the above symptoms have presented themselves, antiphlogistic remedies assume their historic value, but we must not forget that at the same time the position of the limb should not be neglected, so that if absolute stiffness of the joint should occur, this may result in the position relatively most favorable for its usefulness, that is, in the knee-joint fully extended, in the foot and elbow at a right angle, etc. If attention to this point was neglected at the commencement of the treatment, you should repair the error by anaesthetizing the patient, so that you may, without difficulty, give the limb the proper position. Among the antiphlogistic remedies, I attach most importance to pla- cing one or more ice-bladders on the inflamed joint, and painting it with concentrated tincture of iodine, which should be used till a con- siderable extent of epidermis is elevated into a vesicle. If the fluid in the joint increases very rapidly, and the tension becomes insupportable, and if there is no free escape for the pus through the wound, so that there is danger of ulceration of the cap- sule from within, and of the pus flowing from the joint into the cel- lular tissue, we may carefully draw off the pus with a trocar, of course guarding against the entrance of air into the joint. This tap- ping of the joint, which of late has been specially recommended by JR. Vblkmann, I formerly used with good results, and by it cured, as I believe, four successive cases of severe, acute, traumatic inflamma- tion of the knee-joint, with perfect restoration of mobility. Since I have applied the plaster-bandage in simple penetrating wounds of the joint also, I have not resorted to tapping. If the patient is kept awake at night by pain, he should have a dose of morphine in the evening, and antiphlogistic diet and cooling drinks during the day. By this treatment we may succeed in cutting short the acuteness of the disease, even in this stage ; but even then the function of the joint may not be fully restored, although this is possible in case the suppuration of the synovial membrane remams chiefly superficial (catarrhal). Frequently, however, the disease passes from an acute to a chronic course, the suppuration attacks the tissue more deeply, then after recovery there remains more or less stiffness. TRAUMATIC ARTICULAR INFLAMMATION. 239 But, unfortunately, the inflammation in and around the joint occa- sionally extends uncontrollably. And, finally, the only thing to be done is to enlarge the wound, to make new openings in various places ; we then have complete suppuration and destruction of the synovial sac. All the communicating synovial sacs do not partici- pate equally in the suppuration ; on tapping, you may at one part of the joint evacuate serum, at another, pus ; this is probably because the swollen synovial membrane closes, like a valve, the openings of communication, which are often narrow between the cavity of the joint and the adjacent sacs. In bad cases the suppuration extends to the soft parts of the thigh and leg, the patient is thus exhausted more and more as he also is by severe fever and chills, his cheeks sink, and we hesitate about our treatment. Recovery is possible, even in this stage ; the acute suppurations gradually cease, and the disease becomes chronic, and after several months may terminate in complete stiffness of the joint. In many cases we strive in vain to keep up the strength of the patient with tonics and strengthening remedies, but he dies of exhaustion as a result of new suppurations which even occur at points having no connection with the wound. This unfortunate termination we can only prevent by amputaion; this remedy which is so deplorable, but which in these cases frequently saves life. The difficulty here lies in the choice of the proper time for operating. Observations at the bedside, which you will make in the clinic, must teach you how much you may trust the strength of your patient in individual cases, so that you may determine when the last moment for the operation has come. In hospital, you will always see many such cases die of purulent infection (pysemia), with or without amputation. Since, in describing traumatic articular inflammation, we held to the presentation of a special case, and let the treatment follow the symptoms, we must add a few remarks about the pathological anat- omy, as it has been accurately studied on the cadaver, on amputated limbs, and by aid of experiments. The disease affects chiefly, and at first exclusively, the synovial membrane. If this has not been accu- rately observed, as I know from my own experience, we are apt to consider it too thin and delicate. But, by examining a knee-joint, you may readily satisfy yourselves that at most points it is thicker and more succulent than the pleura and peritonaeum, and is separated from the fibrous articular capsule by a loose subserous cellular tissue, which sometimes contains much fat, so that you may detach the syno- vial sac of a knee joint from the cartilage as an independent mem- brane. As is well known, it consists of connective tissue, has on its surface pavement epithelium, and contains a considerable capillary net- 240 INJURIES OF THE JOINTS. work near its surface. We have the investigations of Hueter, about the lymphatic vessels of the synovial membrane ; according to them this membrane itself contains no lymphatics, while the subsynovial tissue is said to be very rich in them. This result is surprising, and hence requires repetition with all the aids of modern anatomical art. Since the synovial sacs are serous membranes, it is most probable that they contain lymphatic vessels, such as have been described in the perito- naeum and other serous membranes, by Von Recklinghausen, forming superficial nets covered with epithelium, and partly opening on the surface of the membrane. The surface of the synovial membrane, es- pecially at the sides of the joint, shows a number of tufted processes ; these have well-formed and often complicated capillary nets. Syno- vial membranes share with other serous membranes the peculiarity of secreting a considerable quantity of serum on being irritated. At the same time the vessels become dilated and begin to grow tortuous toward the surface, the membrane loses its lustre and smoothness, and first grows cloudy yellowish-red, and later more red and velvety on the surface. In most cases of acute inflammation a more or less thick fibrous deposit forms on this surface, a so-called pseudo-mem- brane, like that in inflammation of the pleura and peritonaeum. Mi- croscopical examination of the synovial membrane in this state shows that its entire tissue is greatly infiltrated with plastic matter, and that on the surface the collection of cells is so considerable that the tissue here consists almost exclusively of small, round cells, of which the more superficial have the characteristics of pus-cells ; in the immedi- ate vicinity of the greatly-dilated vessels we find the collection of wandering cells particularly great, which is probably because in acute synovitis numerous white blood-cells wander through the walls of the vessels into the tissue, and collect in the vicinity of the vessels ; in this process red blood-corpuscles seem also to escape from the vessels in great quantities. The pseudo-membranes are composed entirely of small, round cells, held together by coagulated fibrine, of whose origin from fibrogenous and fibrino-plastic substance we have already spoken (p. 63). The connective tissue of the membrane has partly lost its striated character, and has a gelatinous mucous consistency, so that it greatly resembles the intercellular substance of granulation-tissue; in the fluid in the joint, which is constantly becoming more cloudy and puruloid, there are at first a few pus-corpuscles, which constantly in- crease in number till the fluid has all the characteristics of pus. Still later the surface of the synovial membrane is so vascular that even to the naked eye it looks like a spongy, slightly-nodular granulation- surface, on which pus is constantly forming, as on an ordinary granu- lating surface. The condition into which the synovial membrane SUPPURATIONS OF JOINTS. 241 passes, in the first stages, most resembles acute catarrh of the mucous membranes. As long as there has been only superficial suppuration without disintegration of tissue (without ulceration), the membrane may return to the normal state ; but, if the irritation be sufficient not only for the formation of pseudo-membrane (which may also be again disintegrated), but to cause suppuration of the synovial membrane it- self, the only result will be formation of cicatrix. In describing a typical case of suppuration of the knee-joint, we have already shown that the pus perforates from the knee-joint into the subcutaneous cel- lular tissue ; this undoubtedly occurs, but periarticular subcutaneous suppurations, after penetrating wounds of joints, also occur occa- sionally without depending on perforations of pus; we see them both in acute and chronic suppurations of joints, without being able to detect a direct communication with the cavity of the joint. From my experiments on the phlogistic action of pus, I think this must be due to the reabsorption of quickly-formed poisonous pus by the lym- phatic vessels of the synovial membrane, and its conduction to the periarticular cellular tissue ; at the same time the neighboring lym- phatic glands are always swollen. When treating of lymphangitis, we shall have to return to this subject. The cartilage does not par- ticipate in the inflammation for some time; its surface becomes cloudy, and, when the process is very acute, it begins to disintegrate to fine molecules, or even to become necrosed in large fragments, and to be detached from the bone by the occurrence of inflammation and suppuration between cartilage and bone (subchondral ostitis). Al- though the cartilage with its cells is not wholly inactive in these inflammations — for, from various observations, we can scarcely avoid believing that the cartilage-cells may also produce pus — still, I consider this state of the cartilage is essentially a passive softening, a sort of maceration such as occurs under like circumstances in the cornea when there is severe blennorrhea of the conjunctiva. Indeed, there are scarcely two parts of the human body so analogous in their relations as the conjunctiva in its relations to the cornea, and the synovial membrane in its relations to the cartilage. We shall frequently have occasion to return to this point, and shall here cease the considera- tions, which we shall resume more particularly hereafter. If the acute process becomes chronic, and a stiff joint results, an anchylosis (from ay/cvXr), bent), it always occurs in the same way in all suppurative inflammations of the joints. We shall investigate this more exactly when treating of chronic articular inflammations. 16 242 INJURIES OF THE JOINTS. LECTURE XVIII. Simple Dislocations ; Traumatic, Congenital, Pathological Luxations, Subluxations. — Etiology.— Difficulties in Eeduction, Treatment; Eeduction, After-Treatment.— Habitual Luxations. — Old Luxations, Treatment. — Complicated Luxations. — Con- genital Luxations. SIMPLE DISLOCATIONS. By a dislocation (luxatio), we understand that condition of a joint in which the two articular ends are entirely, or for the most part, thrown out of their mutual relations, the articular capsule being gen- erally partly ruptured at the same time ; at least, this is almost always the case in traumatic luxations, i. e., in those that have occurred in a healthy joint as a result of the application of force. Besides these, we distinguish congenital, and spontaneous or pathological luxations. The latter result from gradual ulcerative destruction of the articular extremities and ligaments, since there is no longer the natural oppo- sition to muscular contraction ; we shall speak of this hereafter, as it essentially belongs among the results of certain diseases of the joints. At the end of this section we shall say something about congenital luxations. At present we shall speak only of traumatic dislocations. We occasionally hear also of subluxations/ by this expression we imply that the articular surfaces have not separated entirely, so that the luxation is incomplete. By complicated luxations we mean those accompanied by fractures of bones, wounds of the skin, or ruptures of large vessels, or nerves, or all of these. You must also observe that it is customary to designate the lower part of the limb as the part luxated ; as for instance at the shoulder-joint, not to speak of a lux- ated scapula, but of dislocation of the humerus ; at the knee-joint, not of luxation of the femur, but of the tibia, etc. Dislocations generally are rare injuries ; in some joints they are so rare that the whole number of cases known is scarcely half a dozen. It is said that fractures are eight times as frequent as dislocations ; it seems to me that even this is too large a proportion for dislocations. The distribution of luxations among the different joints varies very greatly ; let me show you this by some figures : According to Mai- gaigne's statistics, among 489 dislocations there were 8 of the trunk, 62 of the lower and 419 of the upper extremity, and among the lat- ter there were 321 of the shoulder. Hence you see that the shoulder is a very favorite joint for dislocations, which is readily explained by its construction and free mobility. Dislocations are more frequent among men than women, for the same reasons that we have already shown fractures to be more frequent in men. DISLOCATIONS. 243 As inducing causes for dislocations, we have external applications of force and muscular action ; the latter are rare, but cases have been observed where dislocations were caused, in epileptics, for instance, by muscular contractions. As in fractures, the external causes are divided into direct and indirect. For instance, if one gets a luxation by falling on the shoulder, it is due to direct force; the same luxation might occur indirectly by a person with outstretched arm falling on the hand and elbow. Whether a dislocation or a fracture will result, depends chiefly on the position of the joint and the nature of the cause ; but much also depends on whether the bones or the articular ligaments give way the more readily ; for instance, by the same manoeu- vre on different dead bodies we may sometimes cause fracture, some- times dislocation. As in fractures, there are numerous symptoms of luxation, of which some may be very noticeable, and are the more so the sooner we see the case, and the less the displacement of the ar- ticular ends is hidden by inflammatory swelling of the superjacent soft parts. The altered form of the joint is one of the most important and striking symptoms, but which only leads quickly and certainly to a diagnosis when the eye has been accustomed to readily recognize differences from the normal form. Correct measurement with the eye, accurate knowledge of the normal form, in short, some taste for sculp- ture and sculptural anatomy, so-called artistic anatomy, are here very useful. If there is very slight change of form, even the most prac- tised will not be able to dispense with a comparison with the opposite side, and hence I earnestly urge you, if you would avoid error, always to expose the upper or lower half of the body, as the case may be, and to compare the two sides. You may best follow with the eye the direction of the apparently displaced bone, and if this line does not strike the articular cavity accurately, there will most probably be a dislocation, if there be not a fracture, close below the articulating head of the bone, which must be determined by manual examination. The lengthening or shortening of a limb, its position to the trunk, the distance of certain prominent points of the skeleton from each other, often aid us in making at least a probable diagnosis very quickly. Another symptom perceptible to the sight is ecchymosis of the soft parts, or suggillation. This is rarely distinct at first, because the blood, escaping from the torn capsule only gradually, perhaps not for several days, rises near the skin and becomes visible ; in some cases the effusion of blood is so inconsiderable that it is not perceived. The symptoms given by the patient are, pain and inability to move the limb normally. The pain is never so great as in fractures, and only appears on attempting to move the limb. In some cases, patients with luxations may perform some motions with the limb, but only in 244 INJURIES OF THE JOINTS. certain directions, and to a very limited extent. Manual examination must finally settle the question in most cases ; it must show that the articular cavity is empty, and that the head of the bone is at some other point, at one side, above or below. If the soft parts be consid- erably swollen, this examination may be quite difficult, and the aid of anaesthesia is often necessary for a correct diagnosis, especially if the exhibitions of pain and the motions of the patient interfere. On moving the extremity, which we find springy or slightly movable, there is occasionally a feeling of friction, an indistinct, soft crepitation. This may result partly from rubbing of the head of the bone on torn capsular ligaments and tendons, partly from the compression of firm blood-coagula. Hence, in such varieties of crepitation, we should not at once conclude on a fracture, but be urged to more careful examina- tion. Fractures of certain parts of the articular ends, with disloca- tion, are most readily mistaken for luxations. And formerly the mode of expression on this point was not exact, for displacements about the joint, combined with fractures, and caused entirely by them, were also termed luxations. At present we distinguish these fractures within the joint, with dislocations, more sharply from luxations proper. Should you be in doubt as to whether the case is one of dislocated articular fracture or of luxation, you may easily decide the question by an attempt at reduction. If such a dislocation is readily reduced by moderate traction, but at once returns when you leave off the traction, it is a case of fracture ; for a certain art is necessary to the reduction of a dislocation, and, when once reduced, it does not readily recur, although there are exceptions to this rule. A contusion and sprain of the joint may also be mistaken for lux- ation, but this error may be avoided by careful examination. Old traumatic luxations may sometimes be mistaken for dislocations caused by contraction. Lastly, in paralyzed limbs, where there is at the same time relaxation of the articular capsule, the joint may be so very movable that in certain positions it will look as if dislocated. In these cases, also, the history of the case and careful local examination will lead us to a correct conclusion. Regarding the state of the injured parts immediately after the in- jury, in cases where there has been a chance to examine them, it has been found that the capsule of the joint and the synovial membrane are torn. The capsular opening is of variable size ; occasionally it is a slit like a button-hole, sometimes it is triangular, with more or less ragged edges ; ruptures of muscles and tendons immediately around the joint have also been observed. The contusion of the parts varies greatly, as does also the effusion of blood. The head of the bone does REDUCTION OF DISLOCATIONS. 245 not always remain at the point where it escapes from the ruptured capsule, but in many cases it is higher, lower, or to one side, as the muscles attached to it contract and displace it. It is important to know that we must frequently bring the luxated head of the bone into a different position before we can carry it back through the opening in the capsule into the articular cavity. Occasionally, by some accidental muscular action, the dislocation is spontaneously reduced. In the shoulder, especially, this has been observed several times. But such spontaneous reductions are very rare, because there are usually certain mechanical obstructions to the reduction, which must be overcome by skilful manipulation. These hinderances consist partly in contraction of the muscles, by which the head of the bone may be caught between two contracted muscles ; another far more frequent obstacle is a small capsular opening, or its occlusion by the entrance of the soft parts. Lastly, certain tensions of the capsular or strengthening ligaments may hinder the reposition of recent traumatic luxations. In treating a luxation it must first be skilfully reduced, and then means be employed for restoring the function of the injured limb. We shall here only speak of the reduction of recent dislocations, by which we mean those that are at most eight days old. The most favorable time for reducing a dislocation is immediately after the in- jury ; then we have the least swelling of the soft parts, and little or no displacement of the luxated head of the bone ; the patient is still mentally and physically relaxed from the accident, so that the reposi- tion is not unfrequently very easy ; later, we shall often have to facili- tate the operation by resorting to anaesthetics to remove the opposition of the muscles. Regarding the proper manoeuvres for the reduction, we can say but little in general terms, for this of course depends en- tirely on the mechanism of the different joints. Formerly, it was a general rule, for the reduction of dislocations, that the limb should be brought into the position in which it was at the moment of the dislo- cation, so that by traction the head of the bone might be replaced as it had escaped. This rule is only important in a few cases ; at present, in the different dislocations we are more apt to resort to very different motions, such as flexion, hyper-extension, abduction, adduction, eleva- tion, etc. Usually, the surgeon directs the assistants to make these motions, and himself pushes the head of the bone into place when it has been brought before the articular cavity. Frequently the surgeon alone can accomplish the reduction. I have often thus reduced a dislocation of the thigh over which various colleagues, aided by muscular laborers, had worked in vain for hours. In these cases, every thing depends on correct anatomical knowledge, 246 INJURIES OF THE JOINTS. and you may readily understand that in a certain direction you may not unfrequently slip the head of the bone into place with very little force, while in another position it might be entirely impossible. When the head of the bone enters the articular cavity, it occasionally causes a perceptible snap ; but this does not always occur ; we are only per- fectly assured of successful reposition by the restoration of normal mobility. If we do not succeed alone, or with a few assistants, we have various aids, by applying long slings to the limb, and having several assistants draw in one direction. This traction, which of course must be opposed by a counter-extension of the body, must be regular, not by starts. If we do not succeed, even in this way, we call in the aid of machinery to increase the power. For this purpose various instru- ments were formerly employed, such as the lever, screw, ladders, etc. Now the multiplying pulleys, or Sehneider-MeneVs extension-appara- tus, is almost exclusively used. The multiplying pulleys, an instru- ment that you already know from your studies in physics, for increas- ing power, and which is greatly resorted to in mechanics, are used as follows : One end of the rope is fastened to a strong hook in the wall, while the other is applied to the limb by straps and buckles. Counter- extension is made on the body of the patient, so that it shall not be moved by the extension. An assistant draws on the pulleys, whose power of course increases with the number of rollers employed. Schneider-MeneVs apparatus consists of a strong gallows, to the inner side of one post of which is attached a movable windlass, which may be turned by a handle and held by a toothed wheel ; over this wind- lass runs a strap which is attached by a hook to a bandage applied around the luxated extremity. In luxation of the lower extremity the patient lies on a table placed lengthwise between the posts of the gal- lows, or for reduction of an arm he may be seated on a chair placed the same way ; the counter-extension is made by straps by which the patient is fastened to the other post of the gallows. Both of these apparatuses have certain advantages, but both are troublesome to ap- ply. In your practice you will have little to do with them, as they are almost exclusively employed in old dislocations whose treatment is more rarely undertaken in private practice than in hospitals and surgical clinics. At present, when we undertake this forcible reduction, it is always under the influence of anaesthetics. To produce complete relaxation this anaesthesia must be very profound, and, as the chest is often cov- ered with straps and girdles for counter-extension, the anaesthetic must be very carefully employed to avoid dangerous results. But there are also other dangers which were known to the older surgeons, REDUCTION OF DISLOCATIONS. 247 who did not u,e chloroform. These are as follows : If the patient is tried too long with these powerful remedies, he may suddenly collapse and die ; moreover, the limb may become gangrenous from the press- ure of the straps, or there may be subcutaneous rupture of large nerves and vessels, and consequent paralysis, traumatic aneurism, extensive suppuration, and other dangerous local accidents. The results of pressure from the appliances may best be avoided by applying a moist roller-bandage from below upward, and fastening the straps over this. Since a regular pressure is thus made over the entire limb, the press- ure of the appliance close above the joint does not prove so injurious. The time during which we may continue these forcible attempts at replacement should be at most half an hour ; if we do not succeed in this time, we may be pretty certain of not doing so at all. If we wish to try further in such cases, we should resort to some other method. Until recently, we had no measure of the force that could be used without danger, and had to content ourselves with estimating it. It seems scarcely possible, by the above means, to tear out an arm or a leg ; but not long since this did occur in Paris, and in a case where only manual extension was employed ! Generally, the straps tear sooner, or the buckles bend. Subcutaneous ruptures of the nerves and vessels would scarcely be caused in a healthy arm by regular trac- tion on the whole extremity ; but they may tear, when adherent to deep cicatrices, and are so atrophied as to have lost their normal elas- ticity. If, under such circumstances, the conditions could always be accurately appreciated beforehand, we should frequently entirely ab- stain from attempts at reduction ; for, in such cases, rupture of a nerve or vessel may follow attempts at reposition with the hand, and we cannot refer the accident to the machinery. An instrument has been invented, by whose aid the force employed in extension may be meas- ured. This instrument should be inserted in the extension-apparatus, and shows the force employed in weight, as is customary in physics. According to Malgaigne, we should not go above two hundred kilo- grammes with this dynamometer ; but such directions are of course only approximative. If the reduction has been accomplished, the main point has cer- tainly been gained, but some time is still required for full return of the function of the limb. The wound in the capsule must heal, for which purpose perfect rest of the joint for a longer or shorter time is requisite. After reposition there is always moderate inflammation of the synovial membrane, with a slight effusion of fluid into the joint, and the latter remains for a time painful, stiff, and unwieldy. If re- duction has closely followed the injury, the joint must first be kept per- 248 INJURIES OF THE JOINTS. fectly quiet ; it is surrounded with moist bandages, and cold compresses are applied ; the swelling is rarely so great as to demand other anti- phlogistic remedies. In the shoulder-joint after ten to fourteen days we begin passive motion and continue it till active movements can be made and the arm is fully useful ; frequently, it is many months before movements are quite free, and elevating the arm is the last motion to return. In other joints that have less mobility, active movements may be permitted much sooner ; thus they are restored especially early in the elbow and hip-joints, and in the latter joints we may permit attempts at motion the earlier, because there luxations do not so readily recur. If active motions be permitted too soon after reduction of a dis- location, especially in those joints where dislocation readily recurs, as in the shoulder and lower jaw, and if the luxation recurs once or sev- eral times before the capsular opening has healed, occasionally the capsule does not heal completely, or there is so much distensibility of the capsular cicatrix that the patient only has to make a careless motion to luxate the part again. Then we have the state called habitual luxation, a very annoying state, especially in the lower jaw. I knew a woman who had a dislocation of the jaw and did not take care of herself long enough afterward, so that it soon returned and had to be reduced again ; the capsule was so much stretched that, if, in eating, she took too large a morsel of food between the back teeth, she at once luxated the jaw ; she accustomed herself to the manoeuvre of slipping it into place, so that she could do it with the greatest facility. Such an habitual luxation of the shoulder may occur in the same way. I have seen a young man, who, when gesticulating vio- lently, had carefully to avoid raising his arm quickly, as he almost alwaj's dislocated it by this motion ; such a state is very annoying, and is difficult to cure ; recovery would only be possible by long rest of the joint, but patients rarely have inclination or patience for this treatment. It is well for such patients to wear a bandage that will prevent lifting or throwing back the arm too much ; if the luxa- tion be avoided for a few years, it will not recur so readily. If a simple dislocation be not recognized and reduced, or if, for various reasons, we cannot reduce it, a certain amount of mobility is nevertheless restored, which may be considerably increased by regu- lar use. From the relation of the head of the bone to adjacent bony processes, and from displacement of muscles, it may be readily under- stood that, for purely mechanical reasons, certain motions will be im- possible, while others may approximate the normal mobility. But, if the movements be not methodically restored, the limb remains stiff, the muscles become atrophied, and the limb is of little use. The CHANGES IN OLD LUXATIONS. 249 anatomical changes in the joint and parts around are as follows : the extra vasated blood is reabsorbed; the capsule folds together and atrophies ; the head of the bone rests against some bone in the vicin- ity of the articulating cavity ; for instance, in luxation of the humerus inward against the ribs under the pectoralis major, the soft parts about the dislocated head become infiltrated with plastic lymph and transform to cicatricial connective tissue, which partly ossifies, so that a sort of bony articular cavity again forms, while the head is surrounded by a newly-formed connective-tissue capsule. In the cartilage of the head of the bone, the following changes visible to the naked eye occur : the cartilage becomes rough, fibrous, and grows adherent to the parts on which it lies, by a cicatricial, firm connective tissue. In the course of time this adhesion becomes very firm, espe- cially if not disturbed by movements. The metamorphosis of cartilage to connective tissue, followed microscopically, takes place as follows : the cartilage-tissue divides directly into fine filaments, so that the tissue acquires first the appearance of fibrous cartilage, then of ordi- nary cicatricial connective tissue, which unites with the parts around and receives vessels from them. The surrounding muscles, as far as they are not torn, lose a large part of their filaments, partly from molecular disintegration, partly from fatty metamorphosis of the con- tractile substance; subsequently, new muscular filaments form in these muscular cicatrices. This is what we call an old luxation, and it is in such cases espe- cially that the above methods of forcible reduction are employed. The question, how long a luxation must have existed before its repo- sition is to be considered impossible, cannot be answered since the introduction of chloroform, and is to be differently answered for the various joints. Thus, dislocations of the shoulder may be reduced after existing for years, while those of the hip-joint two or three months old are reduced with difficulty. The chief obstacle lies in the firm adhesions of the head of the bone in its new position, and in the loss of contractility of the muscles, and their degeneration to connective tissue. Another question is, whether, when such old dislocations are reduced, we attain the desired effect on the function, especially in the shoulder. Imagine that the small articulating cavity is filled by the atrophied capsule, and that the head of the bone has lost its cartilage, then, even if we succeed in bringing the head to its normal position, restoration of function may still be impossible, and I can assure you, from my own experience, that the final result of a very tiresome and long after-treatment in such cases does not always repay the patience and perseverance of the patient and surgeon. In such cases, the result will scarcely be more favorable than if the patient tries, by methodical 250 INJURIES OF THE JOINTS. exercise, to make his limb as useful as possible in its new position, which it may have occupied for months or years. We may facilitate this exercise by breaking up the adhesions about the head of the bone, by rotating it forcibly while the patient is anaesthetized. If, as occa- sionally happens in shoulder-dislocations, the head of the bone in its abnormal position so presses on the brachial plexus as to cause paraly- sis of the arm, if reduction be impossible, it may be advisable to make an incision down to the head of the bone to dissect it out and saw it off, i. e., to make a regular resection of the head of the humerus. I have seen a case where, in complete paralysis of the arm after a luxa- tion of the humerus downward and inward, decided improvement of the function of the arm was attained by the above operation, although there was not complete recovery of the paralysis. COMPLICATED DISLOCATIONS. A dislocation may be complicated in various ways; most fre- quently with partial or entire fracture of the head of the bone, which is difficult to cure, and in which reposition is often only partly suc- cessful ; in treatment, attention must always be paid to the fracture ; i. e., a dressing must be worn till the fracture has united. At the same time it is advisable to renew the dressing frequently, say every week, and to apply it in a different position each time, so that the joint may not become stiff. Nevertheless, we cannot always succeed in attaining perfect mobility, so that I can only advise you in your practice always to give a doubtful prognosis in such cases. Another complication is a coincident wound of the joint. For instance, the broad articular surface of the lower epiphysis of the humerus or of the radius may be driven out of the joint with such force as to tear through the soft parts and skin, and lie exposed. Of course the diagnosis is easy in such cases ; reposition is accom- plished according to the above rules, but we still have a wound of the joint ; and we are liable to all the chances spoken of under wounds of joints, so that for the prognosis, the varieties of the possible results and the treatment, I refer you to what has already been said (p. 224). Of course, it is worse when there is an open fracture through the joint ; here we can neither expect rapid closure of the wound nor restoration of the function of the joint, and we run all the dangers that threaten complicated open fractures and wounds of joints. The decision as to what must be done in such cases is easy, when there is at the same time considerable crushing or tearing of the soft parts ; under such circumstances, primary amputation must be done. If the injury of CONGENITAL LUXATIONS. 251 the soft parts be not great, we may sometimes hope for a cure by suppuration, with a subsequent stiff joint ; but, as experience shows, this is always a dangerous experiment. According to the principles of modern surgery, in such cases we avoid amputation by dissecting out and sawing off the fractured articular ends of the bones so as to make a simple wound. This is the regular total resection of a joint, an operation concerning which very extensive observations have been made during the last twenty years, and of which modern times is justly proud ; by its means many limbs have been preserved, which, according to the old rules of surgery, should unhesitatingly have been amputated. In regard to their danger, these resections vary greatly according to the joint on which they are made, so that it is difficult to make any general remarks about them. But, in a subsequent section (in the treatment of chronic fungous diseases of the joints), we shall study this very important point more carefully ; what has been said will give you a general idea of a resection of the joint. CONGENITAL LUXATIONS. Congenital luxations are rare, and we must distinguish them from luxationes inter partum acquisitce, i. e., those that have resulted at birth from manoeuvres in extracting the child, and which are merely simple traumatic luxations which may be reduced and cured. Al- though congenital luxations have been observed in most of the joints of the extremities, they are particularly frequent in the thigh, and not unfrequently occur on both sides at the same time. The head of the bone stands somewhat above and behind the acetabulum, but in many cases it can readily be replaced. As a rule, the disease is first noticed when the child begins to walk. The most noticeable symptom is a peculiar wabbling gait, which is caused by the head of the bone standing behind the acetabulum so that the pelvis inclines forward, and also because in walking the head of the thigh moves up and down ; there is never any pain. To examine the child more accurately, you may unclothe it entirely and watch its gait ; then lay it on the back, and compare the length and position of the extremities. If the luxa- tion be one-sided, the luxated limb will be shorter than the other, and •the foot turned inward ; if you fix the pelvis, you may often reduce the dislocation by simple traction downward. The anatomical exami- nation of such joints has led to the following results : not only is the head of the bone out of the socket, but the socket is irregularly formed — too shallow ; later in life, in adults, it is greatly compressed 252 INJURIES OF THE JOINTS. and filled with fat ; when the ligamentum teres exists, it is abnoimally long ; the head of the bone is not properly developed ; in some cases it is not half as large as normal ; the articular cartilage is usually completely formed, the capsule very large and relaxed. Under such circumstances, you may understand that it is exceed- ingly difficult, in most cases impossible, to effect a cure. If the head be only partially developed, the upper border of the acetabulum ab- sent, and the capsule enormously distended, how shall we restore the normal conditions ? As to the causes of this malformation, the most varied hypotheses have been advanced ; the opportunity has never occurred of studying it in the embryo. There is an arrest of develop- ment from some cause. It is assumed that these disturbances followed previous pathological processes in the foetus, and the most probable hypothesis is that, in very early embryonal life, the joint was filled with an abnormal quantity of fluid, and so distended as to induce rup- ture or at least great dilatation of the capsule. Hoser thinks that abnormal intra-uterine positions may give rise to these luxations. Cure of this state has been attempted in those cases where direct examination has shown the existence of a tolerably-developed head. In such cases the luxation has been reduced, and attempts made to preserve the normal position of the thigh by aid of dressings or band- ages — the child being kept quiet for a year or more. The result of this treatment, which requires great patience on the part of the sur- geon and parents of the child, is shown by experience to be only partially satisfactory, as after this treatment there has only been an improvement of the gait, but rarely a perfect cure ; and, when you read in orthopedic pamphlets of the frequent cure of congenital luxations, you may be sure that in most cases there have been errors of diag- nosis, or there is intentional deception. Congenital luxations of the thigh are never dangerous to life, but, since they are accompanied by a change in the centre of gravity of the body, in the course of time they have an effect on the position and curvature of the vertebral column ; this, and a limping, wabbling gait, are the only inconveniences they cause. There can only be a hope of successful treatment in very early youth ; but, as the surgeon cannot promise a successful result in less than one to three years, few patients are put under treatment. I will here mention a very rare occurrence, which I have only met with once. In certain movements the tendon of the long head of the biceps brachii may slip out of its groove and hang on the bor- der of the greater or lesser tubercle ; then the arm stands fixed in a slightly abducted position. If we hold the shoulder-blade steady and relax the tendon by slowly raising the arm, then by slightly CONGENITAL LUXATIONS. 253 rotating the arm we can easily slip the tendon into place ; the pain ceases at once, and all motions are free. For this luxation to occur, the fascia-like membrane which covers the sulcus must tear or be much relaxed. The former is improbable ; where the latter is the case, the accident readily recurs. Some persons have the covering of the sulcus, in which the tibialis posticus muscle lies, so relaxed that they can voluntarily luxate this tendon and let it snap into place with an audible sound. [Cases where the tendon of the quadriceps femoris and patella may be voluntarily luxated and snapped back into place are prob- ably less rare. The translator, among other cases, has had one pa- tient 18 months old who could do this at pleasure, and when irritated about any thing would snap his patella even if his leg were firmly held. This leg having been placed in a plaster dressing, he began the same performance with the other leg. Then both legs were left free, and after some weeks, when his general health and temper im- proved, the phenomenon ceased.] CHAPTER VIII. G UJSTSHO T-WO ZrJSTJDS, LECTURE XIX. Historical Kemarks. — Injuries from Large Missiles. — Various Forms of Bullet-Wounds. — Transportation and Care of the Wounded in the Field. — Treatment.— Complica- ted Gunshot-Fractures. In war many injuries occur that are to be classed among simple incised, cut, punctured, and contused wounds ; gunshot-wounds them- selves must be classed with contused wounds ; but they have some peculiarities that entitle them to separate consideration, in doing which we must briefly come in contact with the domain of military surgery. Since fire-arms were first used in warfare (1338), gunshot- wounds have received special attention from surgical writers, so that the literature on this subject has become very extensive ; of late, in- deed, military surgery has been made almost a separate branch, which includes the care of soldiers in peace and war, and the special hygienic and dietetic rules which are so important in barracks, in stationary and field hospitals, also the clothing and food. Although the Romans, as was mentioned in the introduction, had surgeons appointed by the state with the army, in the middle ages it was more common for every leader of a troop to have a private doctor, who, with one or more assistants, very imperfectly took care of the soldiers after a battle, and then usually went on with the army, leaving the wounded to the care of compassionate people, without the commander or the army taking the responsibility. It was not till standing armies were formed that surgeons were detailed to certain battalions and companies, and certain (still very imperfect) rules and regulations were made for the care of the wounded. The position of military surgeon was, in those days, very ignoble, and such as we do not hear of now ; for, even in the time of the father of Frederick the Great, the army surgeon was publicly flogged if he permitted one of the long grenadiers to die. At that time, wheD VARIOUS FORMS OF BULLET-WOUNDS. 255 the troops marched to meet the enemy at a parade-step, the move- ments of the army were very tedious and slow ; the large armies had immense trains ; for instance, in the Thirty Years' War, the lancers car- ried along their wives and children in innumerable wagons ; hence, in the medical arrangements pertaining to the train, there was no ne- cessity for greater facilities of motion. The tactics started by Fred- erick the Great required greater mobility of the heavy trains, which, however, was only practically carried out in the French army under Napoleon. As long as a small province remained the seat of war during a whole campaign, a few large hospitals in neighboring cities might suffice ; but, when armies moved about rapidly and had a fight now here now there, it became necessary to furnish more movable, so-called field hospitals, not far from the field of battle, and which could be readily moved from place to place. These ambulances, or flying hospitals, are the idea of one of the greatest of surgeons, Lar- rey, of whom we have already spoken. As I shall shortly tell you what is done with the wounded from the time they are injured till they enter the general hospital, I will here dismiss this subject, and only mention some of the many excellent works on military surgery. Especially interesting, not only medically but historically, are the somewhat lengthy " Memoirs of Larrey," in which I especially recom- mend to you the Egyptian and Russian campaigns. These memoirs contain all Napoleon's campaigns. Another excellent work we have in English literature, John Hennerts "Principles of Military Sur- gery ; " and in German, besides many other excellent works, we have '" The Maxims of Military Surgery," by Stromeyer, which is composed chiefly of experiences in the Schleswig-Holstein War ; and, lastly, " Principles of General Military Surgery, from Reminiscences in the Crimea and Caucasus, and in the Hospital," by Dr. JPirogoff. Wounds caused by large missiles, such as cannon-balls, grenades, bombs, shrapnel, etc., are partly of such a nature that they kill at once, in other cases tear off whole extremities, or so shatter them that am- putation is the only remedy. The extensive tearing and crushing caused by these shot do not differ from other large crushed wounds caused by machinery, which unfortunately now so often occur in civil practice. Musket-balls used in modern warfare differ in some respects : while the small copper bullets with which the Circassians shoot are scarcely larger than our so-called buckshot, large, hollow, leaden bul- lets were used in the late Italian War ; these were much larger than the old-fashioned ones, and were particularly dangerous, because they readily broke upon striking a bone or tense tendon. Besides these, the solid round and conical bullet are used, but their effects do not 256 GUNSHOT-WOUNDS. Fig. 58. «, Chassepot ; b, needle-gun ; c, mitrailleuse-projectiles. Natural size. differ much. The Prussian long bullet, which is held in the cartridge of the needle-gun, is a solid bullet of the form and size of an acorn. You must not think that the projectile, as found in the wound, has the same shape as when put in the gun ; but it is changed in form as it comes out of the rifles of the gun, and is also flattened in the wound, so that we often find it a shapeless mass of lead, which scarcely shows the form of the projectile. We shall now briefly consider the varioU3 injuries that may be caused by a bullet ; in doing which, we shall naturally confine ourselves to the chief forms. In one set of cases the bullet makes no wound, but simply a con- tusion of the soft parts, accompanied by great suggillation and occa- sionally by subcutaneous fracture. According to recent authorities, simple subcutaneous fractures are not very uncommon in war. These injuries are caused by spent bullets, i. e., such as come from a long dis- tance and have not force enough to penetrate the skin ; such a bullet, striking over the liver, may push the skin before it and make a depres- sion in or a rupture of the liver, and then fall back without producing an external wound. Like injuries are caused by bullets striking the skin at a very oblique angle. Firm bodies, such as watches, pocket-books, coins, leather straps on the uniform, etc., may also arrest the bullet. These contused wounds, which, especially when affecting the abdomen or thorax, may prove very dangerous, have always excited the atten- tion of surgeons and soldiers ; formerly they were always referred to the so-called " wind of the ball," and it was thought that they were caused by the bullet passing very close to the body. The idea thai injuries could be caused in this way was so firmly established, that even very well-informed persons worried themselves in trying to ex- plain theoretically how the}' resulted from the wind of the ball. One said that the air in front of and near the bullet was so compressed VARIOUS FORMS OF BULLET-WOUNDS. 257 that the injury was due to this pressure ; another thought that, from the friction in the barrel of the gun, the bullet was charged with electricity, and could in some unknown manner cause contusion and burning at a certain distance. If the conclusion that the whole idea of the wind of balls was a fable had been arrived at sooner, these fantastic theories would not have arisen. Contusions from spent and oblique bullets are to be treated like other contusions. In the second case, the bullet does not enter the soft parts deeply, but carries away part of the skin from the surface of the body, leaving a gutter or furrow. This variety of gunshot- wound is one of the slightest, unless, as may happen in the head, the bone is grazed by the bullet, and portions of lead remain in the skull. The third case is where the bullet enters the skin without escap- ing again ; the bullet enters and generally remains in the soft parts ; it makes a tubular wound. Various other foreign bodies may be car- ried into these wounds, such as portions of uniform, cloth, leather, buttons, etc. ; a bone may also be splintered, and the splinters driven into the wound and tear it. After perforating the skin and soft parts, the bullet might rebound from a bone and fall out of the same opening, so that you would not find it in the wound, in spite of there being only one opening. The wound that the bullet makes on entering the body is usually round, corresponding to the shape of the ball ; its edges are contused, occasionally bluish-black, and somewhat inverted. These characteristics hold in the majority of cases, but are not ab- solute. The fourth and last case is where the bullet enters at one point and escapes at another. If the course of the wound is entirely through the soft parts, and the bullet has carried in no foreign body, the point of exit is usually smaller than the entrance, and is more like a tear. If the bullet has struck a bone and driven bone-splinters or other for- eign body before it, the point of exit is occasionally much larger than the entrance ; there may also be two or more points of exit from bursting of the bullet into several pieces or from several splinters of bone. Lastly, splinters of bone may make openings of exit like those from a bullet, while the latter, or part of it, remains in the wound. Too much value has been attached to the distinction of the openings of entrance and exit ; this is only important in forensic cases, where it may be desirable to know from which side the bullet came, as this may give a clew to the author of the injury. The course of the bullet through the deep parts is occasionally very peculiar ; its course is some- times deviated by bones or tense tendons and fasciae, so that we should be greatly mistaken in supposing that the union of the points of entrance and exit by a straight line always represented the course 17 258 GUNSHOT-WOUNDS. of the bullet. In this respect, the encircling of the skull and thorax is most peculiar : for instance, a bullet strikes the sternum obliquely, but without sufficient force to perforate this bone ; the bullet may run along a rib under the skin to the side of the thorax, or even to the spinal column, before escaping again ; from the position of the points of entry and exit, we might suppose the bullet had passed directly through the chest, and be greatly astonished when such patients come, without any difficulty of breathing, to have their wound dressed. The complication of gunshot-wounds with burns by powder, such as results from shooting at close quarters, rarely occurs in war. It is not rare in cases of accidents from careless handling or bursting of fire-arms, or from blasting, and may cause the greatest variety of burn. The burnt particles of powder often enter the skin and heal there, giving it a bluish-black appearance for the rest of life. More of this in the chapter on burns. In gunshot injuries, there is said to be scarcely any pain ; the rapidity of the injury is such that the patient only feels a blow on the side from which the bullet comes, and does not for some time perceive the bleeding wound and actual pain. There are numerous examples where combatants have received a shot, especially in the upper ex- tremity, without knowing it till told by some one, or having their attention attracted by the flow of blood. In gunshot, as in contused wounds, the bleeding is usually less f han in incised and punctured wounds ; but it would be a great mis- take to suppose that arteries which have been shot through do not bleed. On the contrary, many soldiers never leave the battle-field, having died from rapid haemorrhage from large arteries. When one has seen a fully-divided carotid, subclavian, or femoral artery bleed, he will know that in a very short time the loss of blood will be so great that the only hope of safety lies in immediate aid ; so that a haemorrhage of two minutes' duration from one of these arteries is certainly fatal. But arteries, even as large as the radial, often bleed but little. The first surgeons who gave us descriptions of gunshot- wounds called attention to this point. Before passing to the treatment of gunshot-wounds, I would briefly picture to you the transportation of and first aid offered to the wounded in battle. For the first aid there are usually established certain temporary places for dressing the wounded, in some sheltered place close behind the line of battle, usually in rear of the batteries ; these are designated by white flags. The wounded are first brought to this spot, either by soldiers or by a trained ambulance corps. Of course, those wounded slightly or in the upper extremities walk to the CARE OF THE WOUNDED. 259 spot. The ambulance corps has proved so efficient in late wars that it will certainly be more trusted to in future. It is composed of nurses trained to bring the wounded from the field, and, when neces- sary, to give them temporary aid, as in arresting bleeding from arte- ries and wounds, etc. They have been trained to carry a patient between two of them, either without other support, or on an impro- vised litter. For this latter purpose they usually carry a lance and a piece of cloth longer and broader than the body. The lances are passed through hems along the sides of the cloth, and a barrow is thus made ; bayonets or swords may be used as provisional splints for supporting a limb that has been badly shot. The wounded are thus brought to the dressing-place, and the first dressings are applied ; these remain on till the patient reaches the nearest field-hospital. At the same time haemorrhage must be securely arrested, and injured limbs so arranged that transportation may do no harm ; bullets, for- eign bodies, and loose splinters of bone near the surface, should be removed, if it can be done quickly and readily. Limbs that have been entirely crushed by large shot should be at onee amputated, if a dressing cannot be so applied as to render transportation possible. The chief object of this dressing-place is to render the wounded transportable ; hence it is not proper to do many or tedious operations there. From the great pressure of the constantly-increasing throng from the front, only the most important cases can be attended to here, and Pirogoff is right, though it seems cruel, when he says the sur- geons should not exhaust their strength on the mortally wounded and the dying. But, if possible, every patient, when carried to the field-hospital, should receive a short written account of what was found at the first examination ; a card, containing a few words, thrust into one of his pockets is enough. The chief point is to tell whethei the ball has been extracted, whether a wound of the breast or abdo- men is perforating, etc., which will save time to the surgeon at the hospital and pain to the patient. Part of the ambulance corps has the further duty of placing the wounded properly in wagons for fur- ther transportation, under direction of the surgeon. For this purpose there are special ambulauces, constructed most variously, which take some patients lying down, others sitting up. There are rarely enough of these, and it is often necessary to use common wagons, covered with hay, straw, etc. These wagons convey the wounded to the next field-hospital, which is established in a neighboring city or town ; for it the largest attainable rooms should be taken. School-houses, churches, or barns, may be seized, although the latter are the best. In these places beds are prepared with straw, a few mattresses, and bedclothes. Surgeons and nurses await anxiouslv the arrival of the 260 GUNSHOT-WOUNDS. first load of patients, having been already notified of the commence- ment of the battle by the thunder of the artillery. Here begins the accurate examination of patients, who were only temporarily dressed on the field, and here operating goes on most actively. Amputations, resections, extractions of bullets, etc., are done by wholesale, and the surgeon who has been anxious for his first operation on a living patient may operate till he stops from exhaustion. This continues till far into the night ; the fight lasts till late in the evening, and it is near morning before the last loads of wounded come in. With bad fights, on a temporary operating-table, and often with unskilful nurses for assistants, the surgeon must at once examine every patient, down to the last, and then operate and dress his wounds. In the field-hos- pitals the wounded have a period of rest, and, if possible, those who have been operated on or are seriously hurt should not be moved to another hospital till healthy suppuration begins and healing has at least commenced. This cannot always be done. Occasionally the place where the field-hospital has been established must be vacated. If one belongs to the vanquished party, and the enemy takes the place where the field-hospital was established, the surgeons are usually taken prisoners with their wounded; for, even when the enemy is most humane, after a great battle there is often such a demand for surgeons that those of the enemy cannot take the proper care of wounded prisoners. A few years since, in Geneva, a convention of European powers determined that surgeons and sanitary supplies should be con sidered neutral. Although there are some practical difficulties in carrying out this principle, it has done great good in the wars of late years, and is capable of still further development. At all events, the idea of considering a wounded enemy as an enemy no longer, but as a patient, is to be prized as a beautiful evidence of advancing hu- manity. When the wounded have all been brought under cover, bedded, and the necessary operations done, and the diet, etc., has been at- tended to, arrangements should be made for their proper disposition. Permanent collection of many wounded men in one place is injurious, and, when the seat of war is a poor country, with few railroad con- nections, the care of the wounded is particularly difficult. Hence, they should be sent off as soon as possible. This may be done, even with the severely wounded, when there is a railroad handy ; when the transportation is less convenient, the more slightly wounded at least can be removed. This system of scattering, which of late has been conducted with excellent results, requires great circumspection and trouble from the superior medical and military authorities, but it has proved advantageous. If houses (barracks), or, in summer, tents, cau TREATMENT OF GUNSHOT-WOUNDS. 261 be erected for those remaining — the severely wounded — that will be best. If this be not practicable, they may be distributed in private houses ; it has proved unadvisable to leave the wounded in school- houses and churches. The war in North America, as well as that between Austria and Prussia in 1866, showed that there were still improvements to be made in military sanitary arrangements. A factor has been added that never before came as an aid, namely, extensive assistance from societies, Sisters of Charity, civil surgeons, and many other persons who, either personally or by money and stores, aided in the care of the wounded. "When this private aid is properly organized, under proper management of the military officers, it may be very useful. Concerning the treatment of gunshot-wounds, views have greatly changed from time to time, according to the point of view from which they were regarded. The oldest surgeons whose opinions we have, considered them as poisoned, and thought, consequently, that they should be treated with the hot iron or boiling oil. The first to op- pose this view successfully was Ambrose Pare, whom you already know to have introduced the ligature for arteries. He relates that in the campaign in Piedmont (1536) he ran short of oil for burning the wounds, and he expected the death of all the patients who could not be treated according to the rules of the time. But this did not hap- pen ; on the contrary, they did better than the chosen few on whom he used the remains of his oil. Thus a lucky accident tolerably soon freed medicine of this superstition. Later it was very correctly ob- served that the great difficulty in healing gunshot-wounds was due to the narrowness of the canal, and attempts were made to obviate this by plugging the wound with charpie or gentian-root. But sensible surgeons soon saw that this still more impeded the escape of pus from the deeper parts, and the correct view commenced to make some headway, that a gunshot-wound was a tubular contused wound. They sought to improve this in a peculiar way, by laying down the rule that every superficial gunshot-wound should be laid open, the opening of a canal leading into the deeper parts was to be enlarged by one or more incisions ; various methods were proposed for chan- ging the contused wound into a simple incised wound by these in- cisions, while, in fact, the only thing that was done was to add an incised wound to the gunshot-wound. The case was somewhat dif- ferent when the rule was given to cut out the whole course of the canal, and close the resulting canal by sutures and compresses, so as to obtain healing by first intention ; this proceeding cannot often be applied, and obtained little reputation. Of late, since the treatment of all wounds is so much simplified, the same thing has happened to 262 GUNSHOT-WOUNDS. Fig. 59. gunshot-wounds which are treated on the same general principles as contused wounds. In these, as in other wounds, the first thing is to arrest any arterial haemorrhage. This is to be done according to the rules already given, the bleeding artery being tied either in the wound itself, or the corresponding arterial trunk being ligated in its continuity ; to accomplish the former, it is generally necessary to enlarge the opening of entrance or exit, otherwise we should not find the bleed- ing artery. If there be no haemorrhage, we should examine the wound, especially any blind canal, for foreign bodies, par- ticularly for the bullet. This may be done most certainly with the finger ; should it not be long enough, or should the canal be too narrow, we may best use a silver female catheter, with which we may feel more certainly and safely than with a probe ; if we feel the bullet, we try to remove it the shortest way, that is, either draw it out at the point of entrance, or, if it lies in a blind canal, close under the skin, we make an inci- sion through the skin and extract it through this, thereby changing the blind canal into a complete one. The extrac- tion of bullets through the opening of entrance may be made by aid of spoon or forceps-shaped instruments. Bullet- forceps with long, thin blades are often difficult to use, because they cannot be sufficiently opened in the narrow canal to seize the bullet, hence many military surgeons prefer the spoon-shaped instru- ment. Such a bullet scoop has lately been suggested by B. v. Langenbeck, and seems very practical ; in it the spoon is movable so as to pass behind the bullet, and push it forward. Still better, it seems to me, is a recently-invented American forceps, whose peculiarity is that they can be opened even in a narrow canal, and they seize very securely. If the bullet be lodged in a bone, we may bore a long gimlet into it, Bullet-forceps, made by Geo. Tiemann & Co., of New York, with sharp points for seizing leaden bullets. TREATMENT OF GUNSHOT-WOUNDS. 263 and try to extract it in that way. If we do not succeed in removing the bullet or other foreign body by the opening of entrance, we proceed to enlarge it to gain more room so as to apply the instruments better. The experience that bullets may often remain in the body without in- jury should warn us against any violent operation that aims only at their extraction. Hence, haemorrhage and difficult extraction of for- eign bodies are the chief indications for primary dilatation of gunshot- wounds. Later, other indications may arise to necessitate it ; but, in the gunshot-wound, such enlargement is not necessary for a cure. This takes place by the throwing off of a small ring-shaped eschar, and the detachment of gangrenous shreds from the track of the wound, till healthy granulation and suppuration begin, and the canal gradually closes from within outward. In most cases the opening of exit cicatrizes before the entrance. Certain obstacles may stand in the way of this normal course ; there may be deep progressive inflamma- tions, rendering necessary new incisions and the employment of ice, as in other deep contused wounds. The first dressing of a gunshot-wound in the field is usually a moist compress, covered with a bit of oiled muslin or parchment- paper, held in place by a bandage or cloth. Frequently nothing further is required than simply keeping the wound moist and covered with charpie, lotions of lead-water, chlorine-water, etc. As yet there are no full observations of the treatment of gunshot-wounds without dressings. They occasionally, though rarely, heal by first intention ; as a rule, they suppurate for a longer or shorter period. One of the chief causes of deep inflammation is the presence of foreign bodies, such as bits of clothing, leather, etc. The presence of the bullet, or a portion of it, is far less dangerous, for the cicatricial tissue may grow around and entirely encapsulate the lead, while the wound closes over it; the patient keeps the bullet in him. But these bullets do not always remain in the same spot ; they partly sink, from their weight, partly are displaced, by muscular action, so that after years they are found at different (generally lower) points : for instance, a bullet may enter the thigh, and subsequently, after being almost for- gotten, may be felt under the skin of the calf or heel, and may thence be readily extracted. I have told you the same thing about needles. But non-metallic bodies seem never able to remain thus without injury in the human body, and hence should always be extracted when discovered in a wound. In gunshot-wounds the fever generally depends on their size and extent, as well as on the accidental suppuration. In the excellently- directed hospital of the Bavarian chief staff-surgeon J3eck, which I visited at Tauberbischofsheim (1866), the thermometer was used for 264 GUNSHOT-WOUNDS. determining the amount of fever ; the results as to fever generally correspond with those in other injuries. [Demarquay (quoted in the Medical Times and Gazette, Septem- ber, 1871) says that in all cases observed, where the temperature fell below 95° Fahr., the patients died.] The special rules to be observed in perforating wounds of the skull, thorax, and abdomen, are given in special surgery ; let us here make a few remarks on the fractures resulting from gunshot-wounds. We have already stated that simple subcutaneous fractures occur from spent or obliquely-falling bullets ; but, in most cases, the fractures are accompanied by wounds of the soft parts. The soft, spongy bones and the epiphyses may be simply perforated by bullets without any splintering. This injury is comparatively favorable ; if the adjacent joint be not opened, the bullet may remain in the bone, and, if it cannot be extracted, may heal there ; the track of the wound in the bone suppurates, fills with granulations, which at least partly ossify, so that the firmness of the bone is not impaired. If the bullet strikes Fig. 60. Femur of a French soldier, broken by a needle-gun bullet. Tibia of a German soldier struck by a chassepot-projectile. TREATMENT OF GUNSHOT-WOUx\ T DS. 265 the diaphysis of a long bone, it generally splinters it, and does so much more extensively than any other cause. The numbers of sharp splinters, and the extent of the splintering in proportion to the diame* ter of the projectile, is the most noticeable feature that we observe when first seeing a large number of gunshot- wounds. I think it is necessary and very important to examine every gun- shot-wound of the extremities with the finger quite early, and to remove fragments that are loose or slightly attached to the soft parts ; it may be advisable now and then to cut or saw off pointed frag- ments where it can be done without much new injury or extensive incisions through the soft parts. But I would not recommend these resections in the continuity as a usual or necessary operation, for ex- perience shows that many such cases go on favorably without opera- tions. If the injury has caused a complicated fracture in a joint, we can- not hope for much from an expectant treatment, according to present experience, which is based on statistics ; the question rather seems to be, whether primary resection or amputation is preferable ; this can only be decided by the peculiarities of each case. Lastly, we must mention that secondary haemorrhages are par- ticularly frequent in gunshot as in other contused wounds. I consider the treatment of gunshot-fractures, by fenestrated plas- ter-bandages, as the only proper method (excepting perhaps those in the upper part of the arm or thigh) ; the only thing against it is, that surgeons who have not already treated open fractures with plaster- dressings, and are not adepts in the application, should not make their first experiments on gunshot-fractures, but should only apply dressings with which they are familiar. Secondary suppurative inflammations occur in gunshot-wounds even more frequently than in other contused wounds; the same causes that we have already learned for these dangerous accidents, unfortunately often act in gunshot-wounds also. We must satisfy ourselves with these few remarks on the subject of gunshot-wounds, glad as I should be to continue the subject. Those who feel special interest in the subject, I refer to the works already mentioned, and to a little book of my own, " Historical Studies on the Consideration and Treatment of Gunshot- Wounds," in which you will find the old literature brought together. CHAPTER IX. BURNS AND FBO S T-BITES. LECTURE XX. I Burns : Grade, Extent, Treatment.— Sunstroke. — Stroke of Lightning. — 2. Frost- bites : Grade. — General Freezing, Treatment. — Chilblains. The symptoms due to burns and frost-bites are quite similar, but are sufficiently distinct to be regarded separately ; we shall first treat of BUENS. These are caused by the flames, when, for instance, the clothes burn, but more frequently by hot fluids, as when children pull vessels of hot water, coffee, soup, etc., off a table on to themselves. And, unfor- tunately, in factories, barns from hot metals, such as molten lead, iron, etc., are not rare, and in every-day life slighter burns from matches, sealing-wax, etc., often occur, as you have all doubtless seen. Besides the above, concentrated acids and caustic alkalies not unfrequently cause burns of various degrees, analogous to those from hot bodies. In burns the intensity and extent of the injury are to be regarded ; we shall hereafter study the latter. The intensity of the burn de- pends essentially on the grade of the heat and the duration of its action ; according to the result of this action, burns have been divided into three grades. These pass into one another, but from the accom- panying symptoms may be distinguished without difficulty; the only ob- ject of this is to render explanation easier. We assume three grades. First degree (hyperemia) : The skin is much reddened, very painful, and slightly swollen. These symptoms are due to dilatation of the capillaries, and slight exudation of serum in the tissue of the cutis. There is a mild grade of inflammation, in which there is an increase of cells in the rete Malpighii alone, which is followed, in many cases at least, by detachment of the epidermis. Redness and pair occasion- DEGREES OF BURNS. 267 ally last a few hours, in other cases several days. But it is not neces- sary, and not at all practical, to make several grades on this account. Second degree (formation of vesicles) : Besides the symptoms of the first degree, vesicles arise on the surface of the skin ; before burst- ing these contain serum, clear or mixed with a little blood. These vesicles form immediately, or in a few hours after the reception of the burn, and may vary greatly in size. Anatomically we find that in most of these cases the horny layer is detached from the mucous layer of the epidermis, so that the fluid rapidly escaping from the capilla- ries lies between these two layers, just as results from the action of a blister. The vesicles rupture or are punctured ; from the remaining rete Malpighii a new horny layer of the epidermis forms quickly, and in six or eight days the skin is the same as before. It may also hap- pen that after removal of the vesicle the denuded portion of skin is excessively painful, and for several days, or even a fortnight, there may be superficial suppuration ; the pus finally dries to a scab, under which the new epidermis forms. You may induce this state also artificially by leaving a blister for a long time on one spot. Here also it is un- necessary to make new grades of these variations, for they only de- pend on a little greater or less destruction of the rete Malpighii, while the greater or less pain corresponds to the amount of denuda- tion of the nerves in the papillae of the skin. Third degree (formation of eschars) : By this term we may desig- nate all those cases where there is formation of eschars, i. e., where portions of the skin, and even of the deeper soft parts, are destroyed by the burn. Of course, the varieties may be very great, as in one case there may be only burning and charring of the epidermis and papillae, in another death of a portion of the cutis, in a third charring of the skin or of an entire limb. In all cases where the papillary layer, with the rete Malpighii, is destroyed, there will be more or less sup- puration, by which the mortified portion will be detached, which of course will leave a granulating wound, that will follow the ordinary course in healing. If only the epidermis and the surface of the pa- pillae be charred, there is only slight suppuration, with rapid replace- ment of the epidermic layer from the remains of the rete Malpighii. From what has been said, you may understand how from four to seven or more degrees might be formed ; but, to make the subject com- prehensible, the three degrees of redness, vesicles, and eschars, are enough. In extensive burns we often find these different degrees combined, and, when the injured part is covered with charred epider- mis and dirt, it is often difficult to determine the degree at any point. If there be suppuration, it may be either superficial or deep ; occasion- ally it appears as if islands of young cicatricial tissue formed in the 268 BURNS AND FROST-BITES. midst of a granulating wound, and this has given rise to the false idea that the latter could cicatrize not only from the edges but from differ- ent points in the midst of the wound. But such cicatricial islands never form where there is total absence of the papillary bodies of the skin, but only from some remnants of the rete Malpighii, as may hap- pen in burns and certain ulcerations to be hereafter mentioned. The prognosis for the function of burnt parts may be inferred from what has been said. We should, however, add that after extensive loss of the skin, as occurs especially from burns of the neck and upper ex- tremities by hot liquids, there is very considerable cicatricial contrac- tion, by which, for instance, the head may be completely drawn to one side of the neck, or anteriorly to the sternum, or the arm fixed in a flexed position by a cicatrix in the bend of the elbow. In the course of time these cicatrices become more distensible and pliable, but rarely to such an extent as entirely to remove the disturbance of function and the disfigurement, so that in many cases plastic operations are necessary to improve these conditions. It was formerly asserted that the cicatrices after burns contracted more strongly than any other cicatrices. But this is only apparently so, for scarcely any other in- jury ever causes the loss of such large portions of skin ; we may readily perceive that, when this does occur (as in plastic operations and after extensive destruction of the skin by ulcerations), the con- traction of the cicatrix is just as great. Entirely apart from the different degrees of burns, their extent is of the greatest importance, as regards their danger to life. It is gen- erally said that, if two-thirds of the surface of the body be burned only in the first degree, death soon occurs, in a manner that has as yet received no physiological explanation. Persons thus injured fall into a state of collapse, with small pulse, abnormally low temperature, and dyspnoea, and die in a few hours or days. In other cases life lasts somewhat longer ; death occasionally results from severe diar- rhoea, with the formation of ulcers in the duodenum, near the pylorus, a complication which also sometimes comes in septicaemia. The rapid occurrence of death from extensive burns has received various ex- planations : first, it was asserted that simultaneous irritation of almost all the peripheral nerve-terminations in the skin was too great an irri- tant for the central nervous system, and hence caused paralysis ; then that the cutaneous perspiration was arrested, and death was to be ex- plained here, as in the case of animals, whose whole body has been covered with an air-tight layer of oil-paint, caoutchouc, or pitch. In the latter hypothesis it is assumed that the excretion by the skin of certain substances, especially of ammonia, is interfered with by the impermeable coating (as by the burning of the skin), and that a fatal TREATMENT OF BURNS. 269 blood-poisoning is thus induced. Lastly, the symptoms might be the result of an intense phlogistic or septic (where there is formation of eschars) intoxication. Should the burn not prove fatal from its extent alone, the great loss of skin and consequent suppuration may prove dangerous, especially for children and old persons ; in the same way the amputations necessary from complete charring of single extremi- ties involve certain dangers, which are the more serious as they affect persons already greatly depressed by the burn. In the treatment of burns in the first and second degrees, more depends on alleviating the pain than on any energetic treatment ; for we cannot hasten the return of the skin to its natural state, but must leave the course of healing entirely to Nature. If there are any vesi- cles, it is not advisable to remove the loosened epidermis, but to open the vesicle by a couple of needle-punctures, and carefully press out the serum, to relieve the tense feeling. It would be most natural to cool the burnt part, by applying cold compresses, or holding it in cold water. But this is not usually very popular with patients, as the cold should be considerable and continued, to relieve the pain very much. The cold-water compresses warm too quickly, and immersion in cold water is only applicable to the extremities, hence cold is compara- tively little used in burns. Numerous remedies are used in burns, whose only effect is to perfectly cover the inflamed skin. Smearing the surface with oil and applying wadding is a very common and pop- ular treatment. Mashed potatoes, starch, and collodion, are also much used as protective coverings for the burned skin. The two former may be regarded as popular remedies ; for extensive burns I cannot praise collodion very much ; the collodion covering cracks readily, and in the cracks the skin becomes sore and very sensitive. Some surgeons use peculiar salves and liniments instead of oil ; such as a liniment of equal parts of lime-water and linseed-oil, salve of equal parts of butter and wax, lard, rind of bacon, etc. Another plan of treatment is with a solution of nitrate of silver, ten grains to the ounce of water ; this is to be painted over the burnt part, and compresses wet with the same to be kept constantly applied. At first the pain from the cau- terization of the parts denuded of epidermis is occasionally very great, but a thin blackish-brown crust soon forms, and the pain then ceases entirely. I particularly recommend to you this plan of treatment when all three degrees of burns are combined. In burns of the third degree, if there is only mortification of the cutis (when this is not charred, but burned by boiling water, it gen- erally becomes perfectly white), the treatment is the same as that above given. Should it subsequently be desirable to hasten the de- tachment of the eschar, cataplasms may be employed to stimulate 270 BURNS AND FROST-BITES. suppuration ; in most cases, however, this will be unnecessary, and the treatment by nitrate of silver may be continued till the eschar is completely detached. If large granulating surfaces remain, especially on parts of the surface that are moved much, and where the neigh- boring skin is not very movable, it may take a long time, often months, for them to heal. Very luxuriant granulations form, and their ten- dency to cicatrize is always very slight. Of the remedies already given for promoting the healing of such wounds, I particularly recom- mend to you the compression of the wound by strips of adhesive plaster, which are of excellent service in some of these cases. In the treatment of cicatricial contractions resulting from these burns, com- pression of the cicatricial bands by adhesive plaster is one of the most important remedies, and you would always do well to try this per- sistently before resorting to excision of the cicatrix, or to plastic operations. If, in a burn of the third degree, there has been charring of a limb, it may often be advisable to amputate at once ; not only because the detachment of a large part of the body is not free from danger, but also because the stumps thus left are unfit for the application of an artificial limb. If called to a case where there is a burn of the greater part of the body, you must give your whole attention to the general condition of the patient, and try to prevent collapse, by the use of stimulants, such as wine, hot drinks, hot baths, ether, ammonia, etc. Unfortunately, in most of these cases, our efforts to preserve life are in vain. Hebra praises the treatment of extensive burns by the continued warm bath, which, under proper circumstances, may be kept up for weeks. Persons with delicate skins, long exposed to the sun's rays, may have slight degrees of burns of the face and neck. This is often ob- served in persons travelling on the mountains. When persons, espe- cially women, who do not usually pass the day in the sun, travel for several bright days in summer, without carefully protecting the face and neck, the skin becomes red, swollen, and very painful ; after three or four days the skin dries to brown crusts, cracks, and peels off. In other persons, with still more irritable skins, vesicles form, which sub- sequently dry up, without, however, leaving any cicatrices (eczema solare). Besides prophylaxis by veils, sun-shades, etc., it is well to cover the skin of such mountain travellers with cold cream or glyce- rine ; the same remedies may also be used in developed sunburn ; if the burnt parts be very painful, we may apply cold compresses. Here we must also speak of sunstroke, or insolation. In our cli- FROST-BITES. 271 mate, this disease occurs almost exclusively in young soldiers, who have to make fatiguing marches in full uniform in very hot, bright weather. There are severe headache, dizziness, unconsciousness, and sometimes death in a few hours. In the Orient, especially in India, this disease is not rare among the English soldiers ; some cases are quite acute, ending with tetanic spasms ; others begin with long pro- dromata, and drag on with symptoms of severe headache, burning skin, continued fatigue and depression, palpitation of the heart, twitching of the muscles, etc. ; even when this state ends in recovery, relapses are common. Patients with sunstroke are to be treated like those with congestion of the brain. Cold affusions and bladders of ice to the head, rest in a cool chamber, purgatives, leeches behind the ears, sinapisms to the nape of the neck, are the proper remedies. Ac- cording to the experience of English surgeons, venesection is injuri- ous. We also have something to say about the effect of being struck by lightning. Probably all of you have at some time seen houses or trees that had been struck by lightning ; we usually see a large rent, a fissure with charred edges. Men and animals may also be struck so as to lose single limbs, but this is not always the case ; usually the lightning travels along the body, in at one place, out at another ; the clothes are rent, or even torn off and cast aside ; peculiar, branched, zigzag brownish-red lines are found on the body ; these have been regarded as representations of the nearest tree, or as blood coagulated in the vessels and shining through ; both views are incorrect ; we do not know why the lightning runs this peculiar course on the skin. If a person be directly struck by lightning, he is usually killed on the spot. If the lightning strike in his immediate vicinity, it induces symptoms of commotion of the brain, paralysis of certain limbs or or- gans of special sense, and occasional extravasations and burns. The latter heal like other burns, according to their degree and extent. Paralysis from lightning is not usually of bad prognosis ; the nervous and muscular activity may return after a longer or shorter time. FEOST-BITES. We may aivide frost-bites into three grades analogous to those of burns ; the first of these is characterized by redness of the skin, the second by formation of vesicles, the third by eschars. The first degree of frost-bite is quite well known ; we might regard the so-called dead- ness of the fingers as its mildest form ; probably each of you has some- time had this in a cold bath, or in winter-time. The finger becomes 272 BURNS AND FROST-BITES. Fig. 61. Traces of lightning (after Strieker). white, the skin wrinkled, the sensation diminished ; after a time these symptoms pass off, the skin becomes red, the finger swells, and there is a peculiar itching and prickling. This increases the more, the more quickly warmth follows the cold. The redness of the skin of this degree of frost-bite differs from that in burns, by its more bluish-violet color. After a time, these symptoms subside and the skin again becomes FEOST-BITES. 273 normal. Generally no remedies are used in these slight cases, but, very properly, patients are warned against warming the parts too rapidly ; rubbing with snow, then gradually elevating the tempera- ture, is recommended. The above symptoms are thus explained: First, the capillaries are strongly contracted by the cold, and are then paralyzed for a time. I shall not here discuss the tenability of this hypothesis ; this explanation involves all the difficulties that we have already met in the theories of inflammation. Redness following a frost-bite may sometimes remain permanent, i. e., the capillaries remain dilated. This is especially apt to occur in frost-bites of the nose and ears, and is usually incurable. In Ber- lin, I treated a young man who had a dark-blue nose, as a result of frost-bite, and wished at all hazards to be relieved of the deformity. He persistently pursued the different modes of treatment ; first, he had the nose painted with collodion, after which it looked as if varnished, and, as long as the coating of collodion continued, it was somewhat paler, but the improvement was not permanent. Then the nose was painted with dilute nitric acid, which gave it a yellow tint. After detachment of the epidermis the evil again appeared improved for a time ; but it soon returned to its former state. Then we tried treatment with tincture of iodine and nitrate of silver, which for a time gave the nose a brownish-red, then a brownish-black color. The patient bore all these changes of color heroically, but the perverse capillaries continued dilated, and the nose remained bluish red at the last, just as it had been. I still thought of trying cold, but feared the condition might be made worse, and, after several months' treatment, had to tell the hero of this tragi-comical history that I could not cure him. The treatment of chilblains and the consequent ulcers, of which we shall speak immediately, may be just as difficult. , Frost-bite, where, besides redness of the skin, there is formation of vesicles, is more severe ; it is often accompanied by complete loss of sensation of the affected part, and there is always danger of mortifica- tion. The formation of vesicles in frost-bite is prognostically much worse than it is in burns. The serum contained in the vesicles is rarely clear, but usually bloody. A limb completely frozen is said to be perfectly stiff and brittle, and small portions are said to break off like glass, if carelessly handled. I have had no opportunity to verify these statements, but remember that, when I was a student, a man was was brought to the Gottingen surgical clinic with both feet frozen ; during transportation to the hospital, they had become spontaneously detached at the ankle-joint, so that they hung only by a couple of. tendons. Double amputation of the leg above the malleoli had to be made. How far a limb may be entirely frozen, so that the circulation 18 274 BURNS AND FROST-BITES. is entirely arrested, frequently cannot be determined for a time; hence we must not be too hasty about amputating. In Zurich, I had two cases where both feet were dark blue and without feeling, and on being punctured with a needle only a drop of black blood escaped ; nevertheless, the foot lived, and only a few toes were lost. In a third case, in a very debilitated patient, where both feet as high as the calf were dark blue and covered with vesicles, they became entirely gangrenous. If there be extensive gangrene of the skin, beyond a doubt, we should not delay amputating, for these patients are very subject to pyaemia. A very sad case occurred in the Zurich hospital. A powerful young man had both hands and both feet frozen, so that all became gangrenous ; the patient could not make up his mind to the four amputations, nor could I bring myself to persuade him to the fearful operation. He died of pyaemia. The ends of the extremities, the point of the nose, and tips of the ears, are most liable to be frozen. Closely-fitting clothes, which impede the circulation, increase the predisposition. Cold wind, and cold ac- companied by moisture, induce frost-bite more readily than very great still, dry cold. There is also a total freezing or stiffening of the whole body, in which the patient loses consciousness, and falls into a state of very limited vitality. The radial pulse can hardly be felt, the heart-beat is scarcely audible, the respiration almost imperceptible, and the whole body is icy cold. This state may pass at once into death ; then all the fluids harden into ice. This general freezing is especially apt to occur when the individual, overcome by fatigue and cold, lies down while freezing; he soon falls asleep, and sometimes never wakes again. It has never been accurately determined how long a patient may remain in this stiff condition, with very slight appearance of life, and again recover; we find mention of the state having lasted six days. Whether this be true or not, we should continue our attempts at resuscitation as long as a heart-beat can be detected. Let us commence the treatment of frost-bite with this state of general stiffness. We must here avoid any sudden change to higher temperature, but increase the warmth gradually. Such a patient should be placed in a cool chamber, on a cold bed, and frictions made for several hours. At the same time, artificial respiration should be occasionally tried, if the breathing becomes imperceptible. As slight stimulants that may do good, I would mention enemata of cold water, md holding ammonia to the nostrils. Very gradually, as the patient becomes conscious, we raise the surrounding temperature, keep him for a time in a slightly-warmed room, and at first give only tepid drinks. As the differ/ mt parts of the body, one by one, regain vitality, there is TREATMENT OF FROST-BITE. 275 occasionally some pain in the limbs, especially if they v, ere warmed too rapidly ; in these cases it is well to envelop the painful parts in cloths dipped in cold water. The patient may remain for hours or days in a benumbed, senseless condition, which disappears gradually Of late, experiments have been made in resuscitating stiffened ani« mals, which appear to show that animals are more certainly saved from death by rapid than by slow warming. I should not readily de- cide, from these experiments on animals, to depart from the rules already empirically employed for treatment of persons frozen stiff, and which appear to be correct for local frost-bites, but the question is worth further experiment. Such cases of general freezing rarely escape without loss of some limbs, or parts of them, and, in regard to the treatment of these frozen parts, I can give you little advice. The vesicles are punctured and evacuated; the feet or hands may be wrapped in cold, wet cloths ; then we must wait to see whether and how extensively gangrene will occur. If the bluish-red color passes into a dark cherry-red, the chances of restoration to life are slight. Gangrene will occur in the great majority of such cases. By testing the sensibility with a needle, and noting the escape of blood from these fine openings, we test how far the limb has ceased to live ; but this only becomes certain when the line of demarkation forms ; that is, when the dead is sharply bounded from the living, and inflamma- tory redness develops on the border of the gangrenous parts. But the general condition may become dangerous before the line of de- markation is fully formed ; hence amputation must not be delayed too long if the inflammation after freezing assumes a phlegmonous character. The detachment of single toes or fingers we may leave to itself; but where there is gangrene of a large part of a limb, amputation is decidedly preferable. 9 I will here return to chilblains (perniones), not because they may become particularly dangerous, but because they are an exceedingly annoying disease, and are in some cases very difficult to cure, and for which, as good family doctors, you must have a series of remedies. Chilblains are caused by paralysis of the capillaries, with serous exu- dation in the tissue of the cutis ; they are, as most of you know, bluish-red swellings on the hands and feet, which prove excessively annoying from their severe burning and itching, and from the occa- sional formation of ulcers. They result from repeated slight freezing of the same spot, and do not occur with equal frequency in all per- sons ; they are less annoying in very cold weather than during the change from cold to warm. At night, on going to bed, when the hands and feet become warm, the itching occasionally becomes so troublesome that the patient has to scratch them for hours. In gen- eral, females are more disposed than males, and young persons more 276 BURNS AND FROST-BITES. than old, to chilblains. Employments requiring frequent change of temperature particularly predispose to them ; clerks and apothecaries, who stay for a time in a warm room, then in a cold cellar or ware- house, are frequent subjects. But no station is exempt ; people who always wear gloves, and rarely go out in winter, may be attacked as well as those who have never worn gloves. Among females, chlorosis and disturbances of menstruation occasionally seem to predispose to them ; generally, frequent returns of frost-bite appear to be connected with some constitutional anomaly. As regards treatment, it is usually very difficult to combat the causes due to constitution aod occupation ; hence we are chiefly lim- ited to local remedies. In Italy, where the disease is very frequent, if a cold winter occurs, frictions with snow and ice compresses are recommended. With us, these are less used, and do no good, or at most only alleviate the itching for a time. Salve of white precipitate of mercury (one drachm to the ounce of lard), frictions with fresh lemon-juice, painting with nitric acid diluted with cinnamon-water (one drachm to four ounces), solution of nitrate of silver (ten grains to the ounce), and tincture of cantharides, are remedies that you may resort to. Sometimes one answers, sometimes another ; hand or foot baths with muriatic acid (about one and a half to two ounces to a foot-bath, use for ten minutes), and washing with infusion of mustard-seed, are also celebrated. If the chilblains open on the top, they may be dressed with ointment of zinc or nitrate of silver (gr. j to 3 j fat). I have here given you only a small number of the remedies recom- mended, the effect of most of which I have myself proved, although there are a number of others ; at the commencement of your practice you will find these enough for combating this common, trifling disease, CHAPTER X. ACUTE NON-TRAUMATIC INFLAMMATION OF THE SOFT PARTS. LECTURE XXI. General Etiology of Acute Inflammations. — Acute Inflammation: 1. Of the Cutis. a, Erysipelatous Inflammation ; &, Furuncle ; c, Carbuncle (anthrax), Pustula Ma- ligna. 2. Of the Mucous Membranes. 3. Of the Cellular Tissue, Acute Abscesses. 4. Of the Muscles. 5. Of the Serous Membranes, Sheaths of the Tendons, and Subcutaneous Mucous Bursse. Gentlemen: So far we have treated only of injuries, now we shall pass to the acute inflammations which are of non-traumatic origin. Of these cases, those belong to surgery that occur on the outer part of the body ; also those which, occurring in internal organs, are still accessible to surgical treatment. Although I must start with the idea that you already know the causes of disease in general, it still seems necessary to make some preliminary remarks with special reference to the subject of which we are about to treat. The causes of acute non-traumatic inflammations may be divided into about the following categories : 1. Repeated Mechanical or Chemical Irritation. — At the first glance, this seems to come under the head of trauma, but it makes considerable difference whether such an irritation acts once on a tissue or whether it be frequently repeated, for, in the latter case, each suc- ceeding irritation affects a tissue already irritated. An example will make this clear to you. Suppose a person is rubbed continuously by a projecting sharp nail in his boot or shoe ; at first there would be a slight wound with circumscribed inflammation, but afterward the inflammation will spread and become more intense as long as the irri- tation lasts. Let us take another example of chemical irritation : If a person not accustomed to highly-seasoned food eats Spanish pepper 278 ACUTE NON-TRAUMATIC INFLAMMATION OF SOFT PARTS. it would induce temporary hyperemia and swelling of the oral and gastric mucous membrane ; should one continue the use of so acrid a substance for a length of time, he might excite a severe gastritis. Except in cases of the first example, these rapidly-repeated irritations are not frequent in practice, but they have a great deal to do with the origin of chronic inflammation ; when, of themselves insignificant, they act on parts more or less weak. We must again return to this point. 2. Catching Cold. — You all know that by catching cold one may acquire various diseases, especially acute catarrh and inflammations of the joints or lungs ; but we do not know what is the particular inju- rious influence in catching cold, or what immediate changes it causes in the tissues. The rapid change of temperature is blamed as the chief cause of catching cold, but by this means we cannot experi- mentally induce an inflammation, or any similar disease. One catches cold from being heated, and then being exposed to a cold draught for a length of time ; by careful observation he may say just when he caught cold. The cold may have a purely local action ; for instance, one sits for a time at the window, and the cold wind blows on the side of his face toward the window ; after a few hours he is attacked by paralysis of the facial nerve. We may here assume that molecular changes have occurred in the nerve-substance, by which the conduct- ing power of the nerve is lost. Another might get a conjunctivitis from the same cause. These are purely local colds. Another case is more frequent, viz., that on catching cold that part is attacked which in the person affected is most liable to disease, the "locus minoris I'esistentice." Some persons, after catching cold in any way, have acute catarrh of the nose (snuffles) ; others have gastric catarrh, others muscular pains, and still others have inflammations of the joints. Now, as these parts are not always directly affected by the injury (as when one has nasal catarrh from getting his feet wet), we must sup- pose that the whole body is implicated, but the action of the injury is only shown at the locus minoris resistentice. Whether this transfer of such injurious influences to a special part of the body is due to the nerves, or to the blood and other fluids of the body, is a question which cannot at present be decided, and about which physicians are divided into the two great bodies of neuropaths and humoralists. Reasons may be adduced for both views. I rather incline to the humoral view, and regard it as possible that, for instance, chemical changes may occur or be prevented in the skin while sweating, which may have a poisonous effect on the blood, and may act as an irritant now on this, now on that organ. According to the old form of speech, these in- flammations due to catching cold are called " rheumatic " (from pevfia, MIASMATIC INFECTION. 279 flow) ; but this expression is so much misused, and has come into such disrepute, that it should not be employed too often. 3. Toxic and Miasmatic Infection. — We have already (page 167) stated that moist and dry, purulent and putrid, substances brought in contact with a wound induce severe progressive inflamma- tions, if they enter the healthy tissue immediately after the injury or, under certain previously-mentioned circumstances, pass through the granulations of a wound into the tissue. It is true, the body is tolerably protected on its surface by the epidermis, on the mucous coats by thick epithelium, against the entrance of such poisonous and inflammatory materials, but the protection is not perfect. There are many poisonous substances which enter the body through the skin or mucous membrane. Some of them we term poison, such as the secre- tion from glander-ulcers in the horse, or from the carbunculous pus- tules in cattle ; others we only know from their effects, from some circumstances of their origin. There are invisible bodies which we term " miasmatic poisons," or briefly " miasm " (jjuaofia, uncleanness) ; it is supposed that these miasms develop from decomposing organic bodies. Some consider them as gases, others as dust-like particles, others as minute organisms or their germs ; I think that in many cases the latter is the correct view. The action of these poisons varies, inasmuch as some of them have a direct phlogistic action ; in others it is more indirect. Thus some poisons, as pus, cadaveric poison, induce severe inflammation at the point where they enter the body (infectionsatrium) / others excite no inflammation at that point, but are imperceptibly taken into the blood, and, although circulating through all the organs, only have an inflammatory effect on one or a few parts of the body. These poisons are, to a certain extent, only injurious to certain organs ; they have a " specific " action. I shall not here speak of the primary action of this poison in transforming the blood. We do not know the chemically active constituents of most of these poisons which act specifically on one organ or tissue ; we cannot see them circulate, nor can we always see their effects. Hence, you may very justly ask me how we can express ourselves with so much certainty on the subject. We decide on the causes by observing the morbid symptoms, and, in so doing, support ourselves mainly on their analogy to the effects of poisons intentionally intro- duced into the body, especially to those of our most active medicines. If we take the group of narcotics, they all have a more or less be- numbing effect, that is, a paralyzing effect, on the psychical functions, but they have also the most peculiar specific effects. Belladonna acts on the iris, digitalis on the heart, opium on the intestinal canal, etc. We see the same thing in other remedies. By repeated doses of can- 280 ACUTE NON-TRAUMATIC INFLAMMATION OF SOFT PARTS. tkarides we may excite inflammation of the kidneys, by mercury in- flammation of the oral mucous membrane and salivary glands, etc., whether we introduce them into the blood through the stomach, rec- tum, or skin. So also there is an endless number of known and unknown organic septic poisons, of which many, if not all, have also a specific phlogogenous action. I mention only one example : if you inject putrid fluid into the blood of a dog, in many cases, besides the direct blood intoxication, he will have enteritis, pleuritis, or pericar- ditis. Must we not here suppose that the injected fluid contains one or more matters which have a specific inflammatory effect on the intestinal mucous membrane, on the pleura and pericardium ? If we know the point of entrance of the poison, and have some experience of the poison itself, there will rarely be much doubt about the cause and action. But how many cases there may be where neither exists ! I believe that infection is a much more frequent source of inflamma- tions, especially in surgery, than has hitherto been suspected. I would still make a few general remarks about the forms ana course of non-traumatic inflammations. I have already told you that the characteristic of traumatic inflammations is, that they are limited to the wounded part ; if they become progressive, it is generally through mechanical or toxic (septic) irritation. This would imply that inflammations induced by mechanical irritations and toxic actions have a tendency to progress, or at least to diffuseness ; this is true of most inflammations resulting from catching cold, which attack either a whole organ or a large section of one part of the body. In this regard, much depends on the intensity of the mechanical irritation, and, in toxic inflammations, on the quality and quantity of the poison, especially on its more or less intense fermenting action on the fluids permeating the tissues. As regards inflammations due to repeated mechanical irritation and catching cold, we do not always have reason to suppose that their products are more irritating than those of simple traumatic inflammation ; but if, during the latter, the affected part be kept absolutely quiet, and the lymphatic vessels and interstices between the tissues are closed by the infiltration of the parts about the wound, the extension of the products of inflammation into the surrounding parts is much interfered with. But in repeated mechan- ical irritations the tissue is not kept at rest, and consequently the products of inflammation extend unimpeded around the irritated part, and excite new inflammation. In inflammation due to catching cold, according to my humoral view, the materia peccans is poured/ to a whole organ or tissue ; hence, these inflammations are mostly diffuse ACUTE INFLAMMATION OF THE CUTIS. 281 from the commencement. If, from an existing point of inflammation, a phlogogenous material enter the blood, and thence specifically affect any other organ, we call this secondary inflammation " metastatic." But these metastatic inflammations may occur in another and much more evident manner, by means of a blood-clot in the veins, as we shall show in the section on thrombosis, embolism, and phlebitis. Non-traumatic inflammations may terminate in resolution, in firm organization of the inflammatory product, in suppuration, or in morti- fication. But we will now cease treating this subject in general terms, and pass to the inflammations of the different tissues. 1. ACUTE INFLAMMATION OF THE CUTIS. The simple forms of acute inflammation of the skin (spots, wheals, papules, vesicles, pustules), which are grouped under the common name of " acute exanthemata," belong to internal medicine. Only erysipelatous inflammation, furuncle, and carbuncle, are generally spoken of as true primary inflammations of the cutis. I will here remind you that very frequently the skin is secondarily affected, from inflammation of the subcutaneous cellular tissue and muscles, or even of the periosteum or bones. (a.) Erysipelatous inflammation is located chiefly in the papillary layer and in the rete Malpighii. The local symptoms are great red- ness and oedematous swelling of the skin, pain on being touched, and subsequent detachment of epidermis ; these are occasionally accom- panied by very high fever, out of proportion to the extent of the local affection. The disease lasts from one day to three or four weeks. Any part of the skin or mucous membranes may be attacked, but idiopathic erysipelas is particularly frequent in the head and face Like the acute exanthemata of the skin, according to the views cl many pathologists, erysipelas of the head and face should also be re- garded as a symptomatic cutaneous inflammation ; that is, that the local affection was only one symptom of an acute general disease. In that case, surgery would have as little to do with erysipelas as with scarlatina, measles, etc. ; but, as it occurs especially in wounded per- sons, and particularly often around wounds, we must study it more attentively. I consider erysipelas traumaticum not as a symptomatic inflammation of the skin, but as a capillary lymphangitis of the skin, which is always due to infection. We shall treat of this disease more closely among the accidental traumatic diseases, and content ourselves here with having called attention to its relationship. (b.) The furuncle or phlegmon is a peculiar form of inflammation of the skin, usually of typical course. Some of you may know it 282 ACUTE NON-TRAUMATIC INFLAMMATION OF SOFT PARTS. from personal observation. First, a nodule as large as a pea or bean forms in the skin ; it is red and rather sensitive. Soon a small white point forms at its apex, the swelling spreads around this centre, and usually attains about the size of a dollar ; sometimes the furuncle re- mains quite small, about the size of a cherry ; the larger it is, the more painful it becomes, and it may render irritable persons quite feverish. If we let it run its own course, toward the fifth day the central, white point, becomes loosened in the shape of a plug, and pus mixed with blood and detached shreds of tissue is evacuated ; three or four days later suppuration ceases, the swelling and redness gradu- ally disappear, and finally only a punctate, scarcely-visible cicatrix remains. We rarely have the opportunity of anatomically examining such furuncles in their first stage, as they are not a fatal disease ; but, from what we see of the development and from incision, the death of a small portion of skin (perhaps of a cutaneous gland) seems to be the starting-point and centre of an inflammation, during which the blood finally stagnates in the dilated capillaries ; by infiltration with plastic matter, the tissue of the cutis partly turns to pus, partly becomes gangrenous. The peculiarity in all this is, that such a point of in- flammation should, as a general rule, show no tendency to spread, but should throughout remain circumscribed, and terminate with the de- tachment of the little plug above mentioned. There is no doubt that in many cases the cause of single furuncles is purely local. Some parts where the secretion of the cutaneous glands is particularly strong, as the perinseum, axilla, etc., are espe- cially predisposed to furuncles ; they are also particularly common in persons who have very large sebaceous glands and so-called pim- ples, maggots, or comedones. But there are also undoubtedly consti- tutional conditions, diseases of the blood, which dispose to the forma- tion of numerous furuncles on various parts of the body. This morbid diathesis is called furunculosis / should it continue long, it may prove very exhausting ; the patients grow thin, and are greatly pulled down by pain and sleepless nights ; children and weakly old persons may die of the disease. It is very popular to refer furuncles to full-blooded- ness and fatness ; it is believed that fatty food predisposes to them. In my country (Pomerania) they say that persons who suffer much from pustules and furuncles have "bad blood." I should very much doubt the truth of the supposition that fatty food especially disposes to furuncles. You will often find that miserable, atrophic children, and emaciated, sickly people, are frequently attacked by furuncle, and, although the lack of care of the skin has something to do with this, it is not the sole cause. On the other hand, it is also true that well- FURUNCLE AND CARBUNCLE. 283 nourished butchers are often attacked by furuncles ; but this may be otherwise explained, for not unfrequently it may be found that in them the furuncles are due to poisoning by some animal matter ; we should at least always examine for this cause. But I think it is going too far to assume that every furuncle is caused by infection, and is always to be regarded as one symptom of a general suppurative dia- thesis — of a pyaemia. The treatment of individual furuncles is very simple. Attempts have been made to cut short the process, and prevent suppuration, by early applications of ice. But this rarely succeeds, and is a very tire- some treatment, which is not often popular with the patient. I prefer hastening suppuration by warm, moist compresses, and, if the furuncle does not spread too much, to quietly await the detachment of the central plug, then to squeeze out the furuncle, and do nothing more. If the furuncle be very large and painful, we may make one incision, or two crossing each other, through the tumor ; then the natural course of the process is favored by the escape of blood, and the more rapid suppuration. General furunculosis is a difficult disease to treat successfully, es- pecially if we know little of its cause. Usually we give quinine, mineral acids, and iron, internally. Besides these, warm baths con- tinued perse veringly are to be recommended. A perfectly -regulated diet, especially nutritious meats with good wine, is also advisable. The individual furuncles are to be treated as above advised. (c.) Carbuncle and carbunculous inflammation {anthrax) anatom- ically resembles a group of several furuncles lying close together. The whole process is more extensive and intense, more inclined to progress, so that other parts may be affected by the extension of the in- flammation. Many carbuncles, like most boils, are originally a purely local disease. Their chief seat is the hard skin of the back, especially in elderly persons. Their origin and first stage are the same as in furuncle. But soon a number of white points form near each other, and the swelling, redness, and pain, in the periphery, increase in some cases so much that the carbuncle may attain the size of a soup- dish ; and, while the detachment of the white plugs of skin goes on in the centre, the process not unfrequently extends in the periphery. The detachment of gangrenous shreds is much greater in carbuncle than in furuncle. After the loss of the plugs of cutis, the skin ap- pears perforated like a sieve, but subsequently not unfrequently sup- purates, so that after a carbuncle a large cicatrix is always left. But, even when most intense, the process is almost always limited to the skin and subcutaneous cellular tissue ; it is most rare for fasciae and muscles to be destroyed, so that, w T hen a large carbuncle is in the 284 ACUTE NON-TRAUMATIC INFLAMMATION OF SOFT PARTS. vicinity of an artery, the danger of destruction of the arterial walls is more apparent than real, as is shown by experience. 10 After the ex- tensive throwing off of the cellular tissue, and the final arrest of the process in the periphery, healthy and usually very luxuriant granula- tions develop ; healing goes on in the usual manner, and is accom- plished in a time corresponding to the size of the granulating surface. You will have already noticed that the process of formation of furuncles and carbuncles differs from the inflammations with which you are already acquainted, by the constant and peculiar death of portions of skin ; and I have mentioned that this gangrene of the skin, at first very small, is the primary and local cause of furuncles and carbuncles. Of course, this must be induced by an early, per- haps primary, occlusion of small arteries, possibly of the vascular net-work around the sebaceous glands, without our knowing on what final cause this latter depends. The course of the ordinary carbuncle on the back is tedious and painful, although it rarely causes death. But there are cases, especially when the carbuncle or a diffuse carbunculous inflammation occurs in the face or head, which are accompanied by high fever and septic or, as was formerly said, " typhous " symptoms, and which prove danger- ous and are even generally fatal (carbunculus maligna, pustula malig- na). All carbuncles of the face are not of this malignant character; some run the usual course, and only leave a disfiguring cicatrix ; but, as it is difficult and often impossible to tell how the case will turn out, I would advise you always to be very careful about the progno- sis. Unfortunately, I have had such sad experience in these carbun- cles of the face, that in any affection of the kind I am very solicitous about the life of the patient. Let me briefly narrate a case or two. In a young, strong, healthy man, on a journey to Berlin, from some unknown cause a painful swelling began in the lower lip ; it increased rapidly, and soon spread to the whole lip, while the patient became very feverish. The surgeon who was called applied cataplasms, and apparently undervalued the condition of the patient, as he did not see him for two days. The third day the face was greatly swollen and the patient had a severe chill, and was quite delirious when brought to the clinic. I found the lip dark bluish-red with numerous white gan- grenous patches in the skin. Several incisions were made at once, the wounds were dressed with chlorine-water, cataplasms applied, and a bladder of ice placed on the head, as meningitis was beginning. As soon as I saw the patient, I declared his condition hopeless ; he soon fell into a deep stupor, and died twenty-four hours later, four days after the commencement of the carbuncle on the lower lip. Unfor- tunately, an autopsy was refused. I will mention another case : A CARBUNCLE. 285 student in Zurich received a sword-cut on the left side of the head. The wound healed without any remarkable symptoms ; but it was a long while before it closed entirely. For some time there was a small, open wound, which was so slight that the patient paid no at- tention to it. Violent straining while fencing, and perhaps subse- quently catching cold, may have been the causes of the following catastrophe. One morning the young man awakened with consid- erable pain in the cicatrix, and a general feeling of illness ; a rosy redness and moderate swelling of the scalp rendered an attack of simple erysipelas capitis probable. But the fever increased in an unusual manner, without the redness spreading over the head. The patient had a chill, and became delirious. When on the third day he was brought to the hospital, in the vicinity of the cicatrix I found a number of small white spots, which showed me at once that there was carbunculous inflammation ; as the patient was entirely uncon- scious, and for several reasons there was probably inflammation of the meninges of the brain, I had little hope of a cure ; I gave the ne- cessary directions, but the next day the patient was dead. The autopsy showed various white gangrenous points in the inflamed scalp cicatrix ; on seeking further, the neighboring veins were found plugged with clots, and along them the cellular tissue was swollen and con- tained points of pus. Anteriorly I could follow this condition of the veins as far as the orbit, but did not try to follow it farther, not wish- ing to injure the eye. After opening the skull, as soon as the brain was removed, we found in the left anterior cranial fossa a moderately inflamed spot about as large as a dollar ; the disease affected both the dura and pia mater, and even entered the brain-substance. There was no doubt that the inflammation starting from the cicatrix on the head had travelled along a vein into the cellular tissue of the orbit, and thence through the optic foramen and superior orbital fissure into the skull. 11 In many cases of malignant carbuncle of the face, on careful ex- amination we shall find such an extension of the inflammation to the cranial cavity, and consequent disease of the brain. But I must re- mind you that the extent of this inflammation as found in the cadaver is not at all in proportion to the severity of the constitutional symp- toms, so that the latter are by no means fully explained by the post* mortem appearances. Indeed, there are cases, and just the most quickly fatal ones, where death occurs without our being able to find any disease in the brain. Here there is full room for hypothesis ; in the rapid, violent course and the quick change of carbunculous in- flammation to gangrene we suspect a rapidly-occurring decomposition of the blood, of which the carbuncle itself may be either the cause or 286 ACUTE NON-TRAUMATIC INFLAMMATION OF SOFT PARTS. result. But, as the decomposition of the blood must have its cause, it has been supposed that an insect which has alighted on some car- rion, or on the nose of a horse with glanders, or a cow with carbun- cle, etc., lights soon after on a man and infects him ; you will here- after learn that malignant carbuncles result particularly from carbun culous cattle. I know of no cases where this has been actually observed, but I do not consider it impossible in certain cases ; this supposition is supported by the fact that these carbuncles are most frequent on parts of the body which are usually exposed. At all events, the high fever and fatal blood-infection are mostly results of the local disease ; hence, we must suppose that in these carbuncles, under circumstances which we do not exactly understand, peculiarly intense poisons are formed, whose reabsorption into the blood causes death. But the causes of malignant carbuncle are in most cases en- tirely obscure. 12 In diabetes mellitus and uraemia carbuncle occurs, just as sugar is observed in the urine of persons otherwise healthy, who have furuncles and carbuncles ; these are enigmatical facts. 13 For- tunately, carbuncles are not frequent ; even simple benignant carbun- cles are so rare that in the extensive surgical policlinic of Berlin, where every year five or six thousand patients presented themselves, I only saw a carbuncle once in two years or so. In Zurich also they were rare. The diagnosis of ordinary carbuncle is not difficult, espe- cially after you have seen one ; diffuse carbunculous inflammation can only be recognized after a period of observation ; at first it resembles erysipelas. The treatment of carbuncle must be very energetic, if we would prevent the advance of the disease. As in all inflammations disposed to gangrene, numerous incisions should be made early, to permit the escape of the decomposed, putrid tissues and fluids. Hence in every carbuncle you make large crucial incisions, dividing the whole thick- ness of the cutis, and long enough to divide the infected skin clear through to the healthy. If this does not suffice, you add a few other incisions, especially where from the white points you recognize gan- grene of the skin. The bleeding from these incisions is proportion- ately slight, as the blood is coagulated in most of the vessels of the carbuncle. In the incisions you place charpie wet with chlorine-water, and renew it every two or three hours ; over this warm cataplasms may be regularly applied to hasten suppuration by the moist warmth. If the continued warmth be not well borne, as in carbuncle of the neck, where it may induce cerebral congestion, the cataplasms may be omitted and the antiseptic dressings continued alone, or even cold may be resorted to. If the tissue begins to detach, you daily pick off the half-loose tags with the forceps, and so try to keep the wound as ACUTE INFLAMMATIONS OF THE MUCOUS MEMBRANES. 287 clean as possible. Strong granulations will soon appear here and there ; finally, the last shreds are detached and a honeycombed granu- lating surface is left ; this soon smooths off, and subsequently cica- trizes in the usual manner, so that it only requires a little occasional stimulation from nitrate of silver, like other granulating surface. In malignant carbuncle the local treatment is the same that we have just described. For the rapidly-occurring cerebral disease the only thing we can do is to apply ice to the head. Internally we usually give quinine, acids, and other antiseptic remedies. But I must acknowl- edge that the results of this treatment are very slight, for in my own experience I do not know a case where it has succeeded in averting death when septicaemia was at all developed ; this is the more depress- ing, because these malignant carbuncles generally attack young, strong individuals. Even if the course be favorable as regards life, there will be considerable loss of skin and great disfigurement, especially in car- bunculous inflammation of the eyelids or lips, as they are mostly de- stroyed by gangrene. Early incision, excision, and burning out of the carbuncle, also have little effect on the further course of the dis- ease, as I have proved to myself in a few malignant cases. But do not be deterred, by these hopeless views of treatment, from making early incisions, for cases occur where carbuncles on the face run the usual course after commencing with high fever. French surgeons have attained some good results by early burning out the malignant pustule. 2. ACUTE INFLAMMATIONS OF THE MUCOUS MEMBEANES. While traumatic inflammation of the mucous membranes presents nothing peculiar, " acute catarrh " or " acute catarrhal inflammation " of these membranes is a peculiar form of disease which is anatomically characterized by great hyperaemia, cedematous swelling and free secre- tion of a fluid at first serous and subsequently muco-purulent, and is most frequently caused by catching cold or by infection. " Blennorrhea n is an increase of catarrh to such a degree that quantities of pure pus are secreted. Catarrh and blennorrhea may become chronic. Simple observation of exposed mucous membranes affected with catarrh shows that it may be very severe and long continued, without the substance of the membrane suffering much ; the surface of the mem- brane is hyperaemic and swollen, somewhat thick and puffy ; in rare cases there are superficial loss of epithelium and small defects of sub- stance (catarrhal ulcers), but it is only in very rare cases that these cause more extensive destruction. This observation is supported by post-mortem examination and histological investigation. The opinion now is, that there is only a rapid throwing off of the epithelial cells 288 ACUTE NON-TRAUMATIC INFLAMMATION OF SOFT PARTS. which approach the surface as pus-cells, and that the connective-tis- sue layer of the mucous membrane takes no part in the process. Al- though many attempts have been made to find segregation of the cells in the deeper epithelial layers of mucous membranes affected with catarrh, they were unsuccessful till Hemak, Buhl, and Rindfleisch, discovered large mother-cells in the epithelial layers of such mem- branes. Fig. 62. Epithelial layer of a conjunctiva affected with catarrh (after Rindjleisch). Magnified 400 diam- eters. It was most natural to explain this observation by assuming that the mother-cells were formed by endogenous segregation of the pro- toplasm, and subsequently turned out their broods (as pus-cells). Since, in opposition to this view, it was repeatedly shown that, if this were the case, the mother-cells should always be found on catar- rhal mucous membranes, while they were found only at first and then in small numbers, of late, they have been explained quite dif- ferently. Steudener and Vollcmann first advanced the idea that the young cells do not form in the older ones, but that, under certain me- chanically favorable influences, the latter may enter from without, but have nothing to do with the origin of the catarrh. Although this view is very difficult to prove, after much consideration and weighing of known facts, I consider it as very probable. This is not the place to go into details on the matter, but, since it has been proved by the cinnabar method that the white blood-cells escape from the vessels of the inflamed mucous membrane, and not only wander between the epithelium, but are also found as pus-cells in the catarrhal secretion, I should think catarrhal pus had the same origin as other pus, viz. that it came directly from the blood. Besides catarrhal inflammation mucous membranes are also subject to croupous and diphtheritic in flammations. When, in inflammation of a mucous membrane, the prod ucts of inflammation (cells and transudation) appearing on the sur PHLEGMONOUS INFLAMMATION. 289 face form fibrine, and thus become a membrane clinging to the surface, which after a time dissolves into mucus and pus, or is lifted up by pus which is produced behind it from the mucous membrane, we call it a " croupous inflammation ; " the mucous membrane and its epithe- lium meantime remain intact, the parts are perfectly restored. Dip/ir theria is exactly similar to the above process, but the fibrinous layer is not only attached more firmly to the tissue, but the serum per- meating the substance of the membrane coagulates ; the circulation is thus impaired so much that occasionally the affected part becomes en- tirely gangrenous. In diphtheria, the disintegration and gangrene are prominent symptoms ; they probably depend on very rapid devel- opment of germs of fungi and infusoria in the diphtheritic membrane. Whether these fungous germs are, as many suppose, the cause of diphtheria, at present remains doubtful. The general affection, the fever, may be very severe in extensive croupous inflammation (as in the fine bronchi and alveoli of the lungs, croupous pneumonia), but in diphtheria it is of a more septic character ; the latter disease is far the most malignant. The mucous membrane of the pharynx and trachea is often exposed to both forms of the disease. Catarrhal con- junctivitis, wm\;h is so very common, may become diphtheritic, but rarely becomes croupous. The mucous membrane of the intestinal canal is seldom the seat of these diseases, the same is true of the mu- cous membrane of the genitals, which are so often affected with con- tagious blennorrhcea (clap, gonorrhoea). 8. ACUTE INFLAMMATION OF THE CELLULAE TISSUE. PHLEGMONOUS INFLAMMATION. This term is pleonastic, for 7] (pXeyfiovr) means inflammation, but practically it is so exclusively applied to inflammation of the cel- lular tissue tending to suppuration, that every surgeon know T s what it means ; another name for the same disease is pseudo-erysipe- las ; it is just as much used, but seems to me less distinctive. The causes of this inflammation are in many cases very obscure ; a severe cold can rarely be proved to be the cause; frequently these in- flammations might result from infection, even if the cutis be unin- jured, but this is only hypothesis ; we have already seen these pro- gressive acute inflammations as a complication in injuries, especially as a-result of local infection from mortifying shrec^ of tissue in con- tusions and contused wounds. Spontaneous inflammation of the cel- lular tissue is most frequent in the extremities, more frequent above than below the fasciae, especially prone to affect the fingers and hand ; here it is called panaritium (corrupted from paronychia, inflammation around the nail, from ovvi- nail), and to distinguish it from deeper 19 290 ACUTE NON-TRAUMATIC INFLAMMATION OF SOFT PARTS. inflammations also occurring in the fingers and hand, panaritium sub- cutaneum. If the inflammation affect the vicinity of the nail, or the nail-bed itself, it is termed panaritium sub ungue. Let us first con- sider the symptoms of phlegmon of the forearm : it begins with pain, swelling, and redness of the skin, and usually with high fever ; the skin of the arm is somewhat oedematous and very tense. With this commencement, which always announces an acute inflammation of the arm, its seat may vary greatly, and in the first day or two you may be unable to decide whether it is a case of inflammation of the subcutaneous cellular tissue, of perimuscular inflammation below the fascia, or even of periostitis or ostitis. The greater the oedema, the more considerable the pain, the less the redness of skin, and the less intense the fever, the more probably you have to anticipate a deep- seated inflammation which will terminate in suppuration. If the in- flammation attacks only the subcutaneous cellular tissue, and goes on to suppuration, as it does in most cases (though resolution is seen), this evinces itself in a few days by the skin becoming red at some point, and distinct fluctuation occurring. Then the pus either per- forates spontaneously, or is let out by an incision. If the inflamma- tion affect parts of the body where the skin, and especially the epi- dermis, is particularly thick, as in the hands and feet, there is at first little perceptible redness, as it would be hidden by the thick layer of epidermis. Pain, and a peculiar tension and throbbing in the inflamed part, announce the formation of pus under the skin. In some of these cases a portion of the skin becomes gangrenous, the circulation being disturbed by the tension of the tissue, part of the skin loses its vitality. The fasciae also are occasionally threat- ened by these inflammations ; in such cases they come through the openings of the cutis as large, white, consistent, thready tags. This is particularly the case in inflammations of the scalp, which not un- frequently extend over the entire skull ; the whole galea aponeurotica may thus be lost. Let us now pass to the more minute anatomical changes that take place in acute inflammation of the cellular tissue ; we shall not here return to the dispute as to whether vessels, tissues, or nerves, are first affected, but shall only speak of what we can find on direct anatomical examination. A series of observations on the cadaver, where in various cases we see inflammation in different stages, gives us sufficient infor- mation on this subject. The first things we find are distention of the capillaries and swelling of the tissue by serous exudation from the vessels, and a rich, plastic infiltration, varying with the stage, i. e., the connective tissue is filled with quantities of young, round cells. This, then, is the anatomical condition of the cellular tissue under the PHLEGMONOUS INFLAMMATION. 291 oedematous, reddened, painful skin; subsequently the collection of cells in the inflamed connective tissue and fat becomes more promi- nent. These tissues become tense, and there is stagnation of blood in the vessels at various points, especially in the capillaries and veins ; at some places the circulation ceases entirely. This stagnation of the blood, which at first causes a dark-blue color, and then whiteness from the rapid discoloration of the red blood-cells, may extend so far as to cause extensive gangrene of the tissue, a result which we have already mentioned. But in most cases this does not occur, but while the cells increase, the fibrillar intercellular substance disappears, partly by the death of small tags and particles, partly by gradually becoming gelat- inous, and finally changing to fluid pus. Fig. 63. Tissue from a prepuce infiltrated from inflammation. The filamentary fibrillar formation of the tissue has entirely disappeared, from the softening influence of the cellular inflammation. The walls of the vessels are relaxed and perforated. Magnified about 500. As the inflammation progresses the entire inflamed part is finally changed to pus, that is, to fluid tissue, consisting of cells with some serous intercellular fluid which is mixed with shreds of dead tissue. If the process goes on in the subcutaneous cellular tissue, extending in all directions (most rapidly where the tissue is most vascular and richest in cells), the purulent destruction of tissue or suppuration will extend to the cutis from within, perforate it at some point, and through this perforation the pus will escape outwardly; when this occurs, the process often ceases to extend. The tissue surrounding the purulent collection is filled with cells and very vascular ; anatomi- cally it closely resembles a granulating surface (without any distinct granulations) lining the whole cavity. When the pus is all evacuated 292 ACUTE NON-TRAUMATIC INFLAMMATION OF SOFT PARTS. the walls come together and usually unite quickly. The plastic infil- tration continues for a time, causing the skin to remain firmer and more rigid than usual. But, by disintegration and reabsorption of the infiltrating cells, and transformation of the connectiYe-tissue substance, this state also returns to the normal. You will readily perceive that, anatomically, the process is much the same whether it be diffuse or circumscribed ; the finer changes of tissue in uie two are just the same. But in practice we distinguish between purulent infiltration and abscess. The first expression ex- plains itself: by an abscess we usually understand a circumscribed collection of pus, excluding further progress of the inflammation ; those forming rapidly, from acute inflammation, are called acute or hot abscesses, in contradistinction to cold abscesses, or those due to chronic inflammation. The following figure (Fig. 64) may render the formation of abscess more clear to you. You here see how the young cells gradually collect at the points where the connective-tissue corpuscles lay, while intermediate sub- stance constantly decreases, and how in the middle of the drawing, in the centre of the inflamed spot, the groups of cells unite and form a collection of pus ; every abscess at first consists of such separate col- lections of pus ; it grows by peripheral extension of the suppuration. Formerly, it was not doubted that, wherever pus-cells thus appeared Fig. 64. Diagram of purulent infiltration of the cutis connective tissue, forming an abscess in the middle. Magnified 350 diameters. in groups, they were to be regarded as a production of connective- tissue cells ; according to our present views, there is no doubt that these young cells are escaped white blood-cells, and are simply grouped PHLEGMONOUS INFLAMMATION. 293 together from mechanical causes. The fat, which is usually plentiful in the subcutaneous cellular tissue, is generally destroyed in acute Fig. 65. Purulent infiltration of the cellular membrane. Magnified 350 diameters ; from a preparation hardened in alcohol. inflammation, the fat-cells being compressed by the new cell-masses, and the fat becoming fluid ; subsequently, it is occasionally found in the shape of oil-drops mixed with the pus. In this preparation you may see the microscopic appearance in inflammation of the cellular membrane. In examining such preparations we not unfrequently find filaments of coagulated fibrine infiltrated in the tissue ; possibly it is formed at the commencement of the inflammation, as previously described ; but it is also possible that these filaments appertain only to the fully- formed pus — possibly they are produced by the alcohol. I must call your attention to the fact that, until the process is arrested, we always have a progressive softening of the tissue, or sup- puration, in which it differs from a developed granulating surface, which only forms pus on its surface. All suppurative parenchymatous inflammations have a destructive or deleterious action on the tissue. As regards the relation of the blood-vessels to the new formation of the young tissue and its speedy disintegration, it has already been stated that they are at first dilated, and then the blood stagnates in them ; if the circulation be entirely arrested in certain portions of tissue, in which case the coagulation in the veins occasionally extends a considerable distance, the walls o£ the vessels and the clot suppu- rate, or fall into shreds, as far as the border where the circulation 294 ACUTE NON-TRAUMATIC INFLAMMATION OF SOFT PARTS. Flo. 66. Vessels (artificially injected) of the walls of an abscess that had been induced in the tongue of a dog. Magnified 25 diameters. begins again. As we have already seen when studying the detach- ment of necrosed shreds of tissue, vascular loops must form on this border of the living tissue ; that is, the whole inner surface of an abscess, in the arrangements of its vessels, is analogous to a granula- ting surface folded up sac-like. In regard to the lymphatic vessels, we may conclude from analogy that here, as in the vicinity of wounds, they are closed by the inflam- matory neoplasia; special investigations on this subject would be very desirable. So soon and so long as an abscess is surrounded by a vigorous layer of tissue infiltrated with plastic matter, for reasons already mentioned there will be no reabsorption of purulent or putrid substances from the cavity of the abscess. I can give you practical evidence of this, if in the clinic you will smell pus from an abscess near the rectum or in the mouth ; this pus has an exceedingly pene- trating, putrid odor, still is not reabsorbed by the walls of the veins, or is so to only a very slight extent ; symptoms of general sepsis very rarely occur. But at the commencement of inflammation, and later, when it is accompanied by rapid destruction of tissue, as well as in some progressive inflammations around contused wounds, and in phlegmonous inflammation of the cellular tissue, etc., if the lymphatic vessels are not yet stopped by cell-formation, organized inflammatory new formation does not occur, or comes on late as the gangrenous PHLEGMONOUS INFLAMMATION. 295 destruction is being bounded; then the decomposing tissue enters the open lymphatics and acts as a ferment in the blood, causing fever. Although inflammation of the cellular tissue (cellulitis) may occur at any part of the body, it is most frequent in the hand, forearm, knee, foot, and leg. It is often accompanied, and, when extending, preceded, by lymphangitis, of which we shall speak among the accidental trau- matic diseases. The intensity and duration of the fever, accompanying these in- flammations, depend on the quantity and quality of the material re- absorbed. At first a quantity of these matters is thrown into the blood at once, hence at the onset there is usually high fever, some- times chill; as the inflammation progresses, the fever continues; it ceases when further absorption of the inflammatory product is arrest- ed by the above changes of tissue, when the process stops and the abscess is formed. The quality of the inflammatory material formed in cellular inflammation certainly varies greatly ; for instance, in some cases deep in the neck in old people there is such intense poisoning that the patients die without other symptoms. It is here the same as in carbuncle — some cases cause little fever, others produce fatal septic fever. If a phlegmon be due to a dangerous poison, such as that of glanders, we do not wonder at the fatal termination; but for the spontaneous cases it often seems very strange why some should be so very severe, while most of them are relatively mild. The prognosis of phlegmonous inflammations varies immensely with the location, extent, and cause. While the disease, occurring as a metastasis in a general phlogistic or suppurative diathesis, or in glanders, gives little hopes of cure, while deeply-seated abscesses in the walls of the abdomen or in the pelvis are very slow in their course and may prove dangerous from the locality, or, by destruction of fas- ciae, tendons, and skin, may impair the functions, most cases of phleg- mon on the fingers, hand, forearm, etc., are only moderate diseases of short duration, although very painful. The sooner suppuration occurs and the more circumscribed the inflammation, the better the prognosis. As regards the treatment, at the commencement of the disease its aim is to arrest the development of the disease if possible, that is, to attain the earliest possible reabsorption of the serous and plastic in- filtration. For this purpose there are various remedies : first, the ex- ternal use of mercury ; the inflamed part may be smeared with mer- curial ointment, the patient placed in bed, and the inflamed extremity enveloped in warm, moist cloths or large cataplasms. Ice also may be employed at first, if the whole inflamed part can be covered with several bladders of ice. Compression by adhesive plaster and band- ages is also a very effective remedy for aiding absorption, but it is 296 ACUTE NON-TRAUMATIC INFLAMMATION OF SOFT PARTS. little used in these inflammations, partly because of the pain it causes in such cases, partly because the remedy is not free from danger, as gangrene may be easily induced by a little too much pressure. If the process be not moderated soon after the employment of the above remedies, but all the symptoms increase, we must give up the hope of resolution, and resort to remedies to hasten the suppuration which we cannot avert; the chief of these is the application of moist warmth, especially in the shape of cataplasms. Then, as soon as fluctuation is detected at any point, we do not usually leave the perforation to Na- ture, but divide the skin to give vent to the matter; if the suppuration extends under the skin, we make several openings, at least I prefer this to one very large incision, from the elbow to the hand for instance, because in the latter the skin gapes widely, and takes a long time to heal. If the pus escapes naturally from the openings, great cleanliness is the only thing necessary; this is greatly assisted by local warm baths. 14 While it is a very simple thing to open subcutaneous abscesses, " oncotomy " of deep abscesses requires great attention to the anato- my of the locality : for instance, the diagnosis may be very difficult in suppurations deep in the neck, in the pelvis, in the abdominal wall, etc., and can only be certainly made after a long period of observation; still, partly for the relief of the patient, partly to avoid a spontaneous opening into the abdomen, perhaps it may be desirable to evacuate the pus early. In such cases we must not plunge a bistoury boldly in, but dissect up layer after layer, till we reach the fluctuating cover- ing of the abscess ; then introduce a probe carefully, and dilate the opening by extending the blades of forceps introduced into it, so as to avoid haemorrhage from the deeper parts. Occasionally decompo- sition of the pus in an abscess causes so much gas as to give rise to a tympanitic percussion-sound; after being opened, these putrid abscesses should be syringed out and dressed with chlorine- water. 4. ACUTE INFLAMMATION OF THE MUSCLES. Idiopathic acute inflammation of muscular substance is rela- tively rare. It occurs in the muscles of the tongue, in the psoas, pectoral, and gluteal muscles, and in those of the thigh and calf of the leg ; the usual termination is in abscess, although resolution has been observed. Metastatic muscular abscesses are very frequent in glanders. Regarding the special histological conditions, the in- terstitial connective tissue of the muscles, the perimysium is here, as in traumatic myositis, the chief seat of the purulent infiltration; from the very acute disease, the nuclei of the muscular filaments INFLAMMATION OF THE SHEATHS OF TENDONS. 297 are destroyed, with the contractile substance and the sarcolemma; only on the stumps of the muscular filaments in the capsule of the abscess do we find the muscular nuclei (muscular corpuscles) in groups and adherent to the cicatrix ; in such cases, according to O. Weber, there is a considerable new formation of young muscle-cells. The symptoms of an abscess in the muscle are the same as those of any deep abscess ; their periods of development and perforation vary with their size and extent. In many cases there is contraction of the muscles in whose substance the abscess develops, as in psoitis. I shall not discuss whether this is the physiological result of the inflammatory irritation, or whether it is half voluntary, and made instinctively by the patient, but am rather inclined to the latter view, for in small and not very painful abscesses and in traumatic inflammations of the muscles, there is usually no contraction, but this occurs only in large ab- scesses, which are compressed by strong fascia?. 15 Abscesses in muscles should be opened as soon as fluctuation is felt, and the diagnosis certain. A very peculiar form of disease of the muscles, which, according to my view, should be classed among subcutaneous inflammations, has been recently discovered and described by Zenker; it occurs chiefly in typhoid fever, in the adductor muscles of the thigh ; in it the contrac- tile substance in the sarcolemma crumbles and is gradually absorbed, while new muscular filaments form to replace the old. Thus, in most cases, the parts are fully restored ; in other cases permanent atrophy of the muscle remains. There is no accurate knowledge as to whether this disease may lead to suppuration, although abscesses of the ab- dominal muscles have been observed after typhus. 5. ACUTE INFLAMMATION OF THE SHEATHS OF TENDONS AND SUB- CUTANEOUS MUCOUS BUES^E (SEEOUS MEMBEANES). As is well known, the sheaths of tendons form shut sacs, which enclose some of the tendons of the hands and feet. They may be- come acutely inflamed from contusion, and in some few cases also spontaneously. Like all acutely-inflamed serous membranes, these sacs at first exude a quantity of fibrinous serum; recent fibrinous pseudo-membranes composed of wandering cells may again dissolve, but they may also induce temporary or permanent adhesions of the sheath to the tendon ; lastly, there is not unfrequently suppura- tion of the membrane, and at this time the tendon may become necrosed. Pain on motion and slight swelling are the first signs of such inflammation ; occasionally there is friction-sound, a grating in the sheath of the tendon, which may be perceived by the hand, or, still better, by the ear. This noise is due to the surfaces of the tendon and of its sheath having become rough from deposits of 298 ACUTE NON-TRAUMATIC INFLAMMATION OF SOFT PARTS. fibrine and rubbing against each other, when the tendons are moved ; this form of subcutaneous inflammation is most common on the back of the hand, and almost always terminates in resolution. The very acute inflammations of the sheaths of the tendons, arising from un- known causes and going on to suppuration, are rare ; they begin like an acute phlegmon ; the subcutaneous cellular tissue quickly partici- pates in the inflammation ; the limb swells greatly, and the adjacent finger or wrist-joint may be drawn into the inflammation. Like the synovial membrane of the joints, that of the tendinous sheaths occa- sionally seems to furnish products that intensely affect the surround- ing parts. If, under suitable treatment, the disease does not go on to suppuration, or, if this be only partial, resolution slowly occurs ; the limb remains stiff a long while; the adhesions between the tendon and its sheath do not break down till after months of use. If there be extensive suppuration of the sheaths of the tendon (which, in the hand, has been termed "panaritium tendinosum"), the tendons usually be- come necrosed, and after a time may be drawn out of the abscess openings as white threads and shreds ; the membrane then degener- ates to spongy granulations. If the process be now arrested, one or more fingers will be stiff, and remain so for life. If the joints be also attacked in the fingers, there may be recovery with anchylosis ; but, if the wrist or ankle-joint be affected, its existence will be greatly endan- gered. In acute suppurative inflammation of the tendinous sheaths, the fever is occasionally slight at first, but in severe cases the disease may begin with a chill. The further the inflammation and suppuration extend, the less the process tends to formation of an abscess, the more continued the fever becomes, and it assumes a distinctly remittent form ; at the same time the patients are rapidly pulled down ; in a few weeks the strongest men emaciate to skeletons. The prognosis is bad when the fever runs on with intermittent attacks and chills. The treatment of subcutaneous, crepitating inflammations of the sheaths of the tendons consists in keeping the part quiet on a splint, and painting it with tincture of iodine ; if this does not afford speedy relief, a blister may be applied ; under this treatment I have always seen this form of inflammation disappear in a few days. If the symp- toms are severe from the first, quiet of the part is the first requisite ; this should be seconded by mercurial ointment and bladders of ice. This treatment should be persistently pursued ; in these cases I de- cidedly prefer it to cataplasms and local warm baths, which are very common. If absceses form, incisions and plenty of counter-openings should be made ; in these cases drainage-tubes are very useful, because the granulations projecting from the openings often obstruct the escape of the pus. If the suppuration will not stop, if the spongy INFLAMMATIONS OF SUBCUTANEOUS MUCOUS BUES.E. 299 swelling of the limb continues, if crepitation appears in the joint be- tween the bones of the wrist (showing that the cartilaginous coverings have suppurated), and if the patient continues to sink, there is little hope of a termination in anchylosis of the hand, but the danger to life is so great that amputation of the forearm should be made ; the patient may thus escape with his life, and will soon recover his strength. Acute inflammations of the subcutaneous mucous bursce are less dangerous ; the bursa praepatellaris and anconea are most frequently affected either from injury or spontaneously ; they are connected neither with the joint nor with the sheaths of the tendons ; they be- come painful, fill with fibrinous serum, the skin reddens, and the cel- lular tissue in the vicinity participates in the inflammation ; but sup- puration rarely occurs if the patient is treated early. The remedies are mercurial ointment or tincture of iodine, keeping the limb quiet, and compressing the swollen bursa by applying wet bandages. Puncture is unnecessary, and may be injurious, from being followed by suppuration and a tedious suppurating fistula. CHAPTER XL ACUTE INFLAMMATIONS OF THE BONES, PERI- OSTEUM, AND JOINTS. LECTURE XXII. Anatomy. — Acute Periostitis and Osteomyelitis of the Long Bones : Symptoms, Ter- minations in Eesolution, Suppuration, Necrosis, Prognosis, Treatment. — Acute Ostitis in Spongy Bones. — Acute Inflammations of the Joints. — Hydrops Acutus ; Symptoms, Treatment.— Acute Suppurative Inflammations of Joints : Symptoms, Course, Treatment, Anatomy. — Acute Articular Bheumatism. — Arthritis. — Metas-. tatic Inflammations of Joints (Gonorrhoeal, Pyemic, Puerperal). The periosteum and the bones are physiologically so intimately connected that disease of one generally affects the other ; although, in spite of this, we are, for practical reasons, obliged to consider acute and chronic inflammation of the periosteum and of bone separately, still we shall often have to refer to their connection. I must here make a few preliminary anatomical remarks, as they are important for the comprehension of the following process : When speaking briefly of the periosteum, we usually mean, simply, the white, glistening, thin membrane, poor in vessels, which immediately surrounds the bone. I must here remark that this represents only a part of the periosteum that is pathologically of little relative importance. Upon this just- described inner layer of the periosteum lies, at points where no ten- dons or ligaments are inserted, a layer of loose cellular tissue, which is also to be considered as periosteum, and in which principally lie the vessels that enter the bone. This outer layer of periosteum is the most frequent seat of primary inflammations, either acute or chronic ; the loose cellular tissue of which this layer consists is very rich in cells and vessels, hence more inclined to inflammation than is the ten- dinous portion, poor in cells and vessels, which lies immediately on the bone. As to nutrient vessels, especially in the long bones, the epiphyses have their own supply, which, as long as the epiphyseal car- ACUTE PERIOSTITIS. 301 triages continue, do not communicate with the vessels of the diaphysis, which have their own nutrient arteries. This distribution of the ves- sels explains why diseases of the diaphyses in young persons rarely pass to the epiphyses and the reverse. Genetically the articular cap- sule is a continuation of the periosteum, and a certain connection is often observed between articular and periosteal diseases, the diseases of one readily passing to the other. In the course of the following observations we shall have occasion to recur to these anatomical con- ditions. First, let us speak of acute periostitis and osteomyelitis, of which you have already heard something in the remarks on suppuration of bone in the chapter on open fractures (p. 221). This disease is not very frequent ; it occurs chiefly in young persons, and in its typical forms almost exclusively in the long bones. The femur is most frequently attacked, next the tibia, more rarely the humerus and bones of the forearm. I have seen the disease occur primarily or secondarily in the vicinity of acutely-inflamed joints, after catching cold, and after severe concussions and contusions of the bones. It is possible that the extravasation into the medulla from crushing or con- tusion of a bone may be reabsorbed, without the occurrence of any symptom but a continued pain as the result of the injury ; but such injuries may occasionally induce chronic affections of various sorts. In many cases we cannot discover whether only the periosteum or the medulla of the bone is affected ; the distinction is usually only ren- dered certain by the subsequent course and by the termination. The symptoms are as follows : The disease begins with high fever, not un- frequently with a chill ; there is severe pain in the affected limb, which swells at first without redness. The severe pain prevents motion of the limb; every touch or the slightest jarring is very painful; the skin is tense, usually cedematous, and occasionally the distended sub- cutaneous veins show through, a sign that the flow of blood to the deeper parts is obstructed. The inflammation may affect the whole or only part of a bone. But these symptoms simply indicate the ex- istence of an intense deeply-seated acute inflammation. But as idio- pathic inflammation of the perimuscular and peritendinous cellular tissue is very unfrequent, and rarely begins with so much pain, we shall not err in most cases if, with the above symptoms, we diagnosti- cate acute periostitis, perhaps accompanied by osteomyelitis. If, while there are great pain and fever, or complete inability to move the limb on account of pain, swelling does not occur for several days, we may suspect that the primary seat of the inflammation is the medullary cavity of the bone, and that at first the periosteum participates but little. In this stage the diseased part is in about the following con- 302 ACUTE INFLAMMATIONS OF THE BONES, PERIOSTEUM, ETC. dition : The vessels of the medulla and periosteum are greatly dilated and distended with blood ; perhaps there may be stasis of blood at different points. The medulla, instead of its usual bright-yellow color, is dark blue, and permeated with extravasations ; the perios- teum is greatly infiltrated, and on microscopical examination of it you find numbers of young cells, as you also do in the medulla ; that is, there is plastic infiltration. In this stage, a complete return to the normal state is possible, and, if proper treatment is begun early, this is not so rare, particularly in the more subacute cases. The fever falls, the swelling decreases, and the pain ceases ; a fortnight after the commencement of the disease the patient may be recovered. Even when the process is somewhat further advanced, it may stop ; then a part of the new formation on the surface of the bone ossifies, and thus, for a time at least, there is thickening of the affected bone, which may again be absorbed in the course of months. In most cases the course of periostitis is not so favorable, but the process goes on, and terminates in suppuration, the symptoms being as follows : The skin of the swollen, tense, and painful limb is at first reddish, then brownish red ; the oedema extends further and further ; the neighboring joints become painful, and swell ; the fever remains at the same point; the chills are not infrequently repeated. The patient is much exhausted, as he eats little, and at night is kept awake by the pain. Toward the twelfth or fourteenth day of the dis- ease, rarely earlier, but often later, we may clearly distinguish fluctu- ation, and may then greatly alleviate the sufferings of the patient by letting out the pus through one or more openings, if the skin over the abscess is sufficiently thinned; for the opening of deep, stiff- walled abscesses which do not collapse may prove dangerous from decompo- sition of blood and pus in the insufficiently-encapsulated abscess. The spontaneous perforation, especially the suppuration of the fascias, occasionally takes a good while, and, moreover, the openings thus formed are usually too small ; they must subsequently be enlarged. If you introduce the finger through one of these artificial openings, you come directly on the bone, and in many cases find it denuded of periosteum. The extent to which this denudation occurs depends on the extent of the periostitis. It may extend the whole length of the diaphysis, and in these worst cases the symptoms are the most severe. Probably, however, only a half or a third of the periosteum is dis- eased, nor is the entire circumference of the bone necessarily affected, but perhaps only the anterior, lateral, or posterior portion is so. The periostitis is particularly apt to stop at the points of origin or inser- tion of strong muscles. In those cases of slight extent all the symp- toms will be milder. ACUTE PERIOSTITIS. 303 Even in this stage the disease may take one of two different direc- tions : possibly, after the evacuation of the pus, the soft parts iaay quickly become adherent to the bone, as the walls of an acute abscess do to each other. I have seen this a few times in periostitis of the femur in children two or three years old. After the opening, a slight quantity of pus continued to discharge for only a short time. The openings soon closed entirely, the tumor receded, and perfect recovery took place. But, according to my experience, such a termination only occurs in small children. More frequently, as a result of the suppu- ration of the periosteum, the bone is mostly robbed of its nutrient vessels, and partly or wholly dies, leaving the condition termed necrosis, or gangrene of the bone. The extent of this necrosis will essentially depend on the extent of the periostitis. The partially or entirely destroyed diaphysis of the long bones must be detached as a foreign body, as we have seen to be the case in gangrene of the soft parts and traumatic necrosis. This requires a long time ; hence the process of necrosis, the detachment of the portion of dead bone or sequestrum, and every thing connected with it, is always a chronic one. We shall have to speak of this hereafter. Before the inflamma- tion passes into this chronic state, acute suppuration continues for a time after the first opening of the abscess. Various complications, even pyaemia, may occur. Whenever these patients are feverish, they are in danger. We must again return to the medulla of the bone, which we left in the first stage of inflammation. Here, also, the inflammation may terminate in suppuration. If the osteomyelitis be diffuse or total, the whole medulla may suppurate. This suppuration may even assume a putrid character, and induce septicaemia. If there be extensive sup- purative osteomyelitis, with suppurative periostitis, death of the dia- physis of the bone is certain. Should there be only partial suppura- tion of the medulla, or if there be none at all, the circulation of blood in the bone may be preserved and the bone remain viable. It may not infrequently occur that, under such circumstances, the bone will waver for a time between life and death, as the feeble circulation nourishes the bone very incompletely. Acute suppurative osteomye- litis, without participation of the periosteum, probably does not occur ; it is not infrequently combined with osteophlebitis, which may end in putrefaction or suppuration of the thrombus, and is prone to induce metastatic abscesses. Another not infrequent, though not constant, accompaniment of osteomyelitis is suppuration of the epiphyseal car- tilages in persons in whom they still exist, that is, till about the twenty-fourth year. The process is not difficult to explain. The sup- puration may extend to the epiphyseal cartilage partly from the 304 ACUTE INFLAMMATIONS OF THE RONES, PERIOSTEUM, ETC. medulla of the bone, partly from the periosteum. If it suppurate, the continuity of the bone is destroyed, and at the seat of the epi- physis there is motion, as in fracture ; dislocations may also be caused by contraction of the muscles. Usually there is only one such epi- physeal separation of the affected bone, above or below ; in rare cases it is double. I have once seen this double separation of the epiphy- ses in the tibia ; several times I have seen separation of the lower epiphysis of the femur, once of the upper end of this bone, once of the lower end of the humerus, twice of the upper end. In one case I saw epiphyseal softening, with luxation of the lower end of the femur, occur without suppuration. It has already been stated that inflammation of the neighboring joints are apt to accompany perios- titis. These articular inflammations usually have a rather subacute course. The serous fluid collecting in the joint is usually reabsorbed as the acute disease of the bone subsides, but the joint often remains swollen, and not infrequently permanently stiff. Several times, also, I have seen acute periostitis and osteomyelitis of the femur succeed acute articular rheumatism of the knee. Lastly, we must also men- tion that this osteomyelitis may occur in several bones at once. The diagnosis as to how far periosteum and bone are affected in the acute disease cannot be made with any certainty, but can only be decided by the extent of the consequent necrosis ; and even this is no accurate measure, for the periostitis may end in suppuration, while the inflammation in the bone may end in resolution, or only cause some interstitial formation of bone. The process may start : 1. In the loose cellular-tissue layer of the periosteum; this suppurates. If the suppuration be limited to this layer, after opening the abscess we may pass the finger directly to the surface of the bone, which we find covered with the granulating tendinous part of the periosteum ; if the latter layer also suppurates, as it not infrequently does, the bone lies exposed, and the suppuration may continue into it. Thus osteomyelitis accompanies periostitis. If it be denied that the loose cellular layer is periosteum, but is to be regarded as part of the inter- muscular cellular tissue (which would not be natural, because the vessels escaping from the bone lie chiefly in this layer), then there is no such thing as acute periostitis ; for the tendinous portion of the periosteum is as little liable to primary inflammation as the fascias and tendons. 2. The inflammation begins in the bone, and thence extends to the periosteum and cellular tissue ; osteomyelitis is the primary, periostitis the secondary, disease. Then there is pus not only in the bone, but on its surface, close under the tendinous portion of the periosteum. This is elevated by the pus, as far as its elasticity per- mits ; it is then perforated, and the pus escapes into the cellular tissue ACUTE PERIOSTITIS. 305 Here it causes more suppuration, and thus the process advances to the surface. Hoser asserts that in these cases fluid fat is pressed, by the strong arterial pressure, from the cavity of the bone through the Haversian canals of the cortical substance to the surface of the bone, so that we may diagnose osteomyelitis from pus mixed with fat-drops rising from under the periosteum. Moreover, in a few cases, Hoser found a remarkable elongation of the bone, and a relaxation of the neighboring joints, after osteomyelitis. He refers this to too rapid growth of the articular ligaments and epiphyseal cartilages. In the prognosis of acute periostitis and osteomyelitis we have to distinguish between the danger to the existence of the bone and to life. If the disease induces partial or total necrosis of the bone, the disease may be very protracted ; it may last several months, or even years. Acute periostitis and osteomyelitis, especially in the femur, and still more when double, is always dangerous to life, because pyae- mia is so apt to occur, and in children, because of the profuse suppu- ration, it is the more dangerous the longer the condition remains acute and the further it spreads. In treating this disease we may accomplish more if we are called early ; one of the most efficient remedies is painting the whole limb with strong tincture of iodine. This remedy should be continued till large vesicles form. Of course the patient is to be kept recumbent, which in most cases does not need to be urged, as the pain keeps him quiet. Since commencing this treatment I am so well satisfied with it, that I have almost given up the other antiphlogistics ; cups, leeches, mercurial ointment, etc. When the vesicles formed by the iodine dry up, you apply more. Derivation to the intestinal canal by saline purgatives aids the treatment, as it does in all acute inflammations. Some surgeons greatly praise the local application of ice at the com- mencement of the disease. Should suppuration nevertheless occur, and distinct fluctuation be felt at the thinnest part of the skin, we may make several openings in such a way that the pus shall escape without being pressed out ; then the swelling usually subsides quick- ly ; it is most favorable when the fever ceases early and the disease becomes chronic. If the fever continues, the suppuration remains profuse, the pains do not cease. We may try to relieve this condi- tion by continued applications of bladders of ice, with which we also try to alleviate any inflammations of the joint that may occur. I have also derived great advantage from the application of a fenestrated plaster-splint, which should be supported with hoops on account of the large openings that must be made in it ; in cases where there is detachment of the epiphysis, it is absolutely necessary that the limb should be fixed, if only to render the daily dressing less painful 20 306 ACUTE INFLAMMATIONS OF THE BONES, PERIOSTEUM, ETC. Many surgeons do not follow this treatment, which is backed by a series of favorable cases. Some recommend making large, deep in- cisions down to the bone at the very start, or at least as soon as suppuration begins. Such extensive wounds are bad in feverish pa- tients ; I am satisfied that, under these circumstances, this heroic treat- ment renders the condition worse, it increases the predisposition to pyaemia. The idea that in acute osteomyelitis exarticulation should be made at once, as otherwise pyaemia is unavoidable, seems to me even more erroneous. This belief is certainly untrue, and under such circumstances amputation is not indicated, first, because at the onset the diagnosis of osteomyelitis is not absolutely certain, as the case might possibly be one of simple acute periostitis ; secondly, be- cause the prognosis in exarticulation of large limbs, if done for acute disease of the bone, is always very doubtful. In acute periostitis and osteomyelitis, of the tibia for instance, I should only amputate at the thigh if the suppuration were very excessive, and acute suppuration of the knee-joint should occur. Should the disease affect the femur and run an unfavorable course, I should scarcely hope to save the pa- tient by an operation so dangerous as amputation at the hip-joint. "We may accomplish much by great care of the patients, who are gen- erally youthful. A young girl with osteomyelitis and periostitis of the tibia had sixteen chills in twelve days, and nevertheless recovered, although part of the tibia became necrosed, and the foot was anchy- losed. I will here add a few remarks about suppurative periostitis of the third phalanx of the finger, which is, perhaps, the place where it most frequently occurs. As this inflammation in the hand and fingers is usually called panaritium, this periostitis of the last phalanx is termed panaritium periostale. This, like any periostitis, is very painful; it is a long while — sometimes eight or ten days — before the pus per- forates outward. The termination in partial or total necrosis of the phalanx is common, and cannot be prevented even by an early in- cision, although we often have to make one to relieve the disagree- able, throbbing, burning pain, partly by the loss of blood, partly by splitting the periosteum. As the termination in suppuration can scarcely ever be avoided, we try to induce it by cataplasms, hand- baths, etc., and thus hasten the course. Thus far we have only spoken of acute inflammation of the peri- osteum, and medulla of the long bones, but have not considered that of the spongy bones. Nor have we considered the question of in- flammation of the bone-substance proper. Is there such a thing ? I think this must be answered in the negative, for I consider that dila- ACUTE PERIOSTITIS. 30 7 tation of the vessels, cell-infiltration, and serous imbibition of the tis- sue, in their various combinations, constitute the essence of acute in flammations. In the compact bone-substance (as in the cortical layer of a long bone) all these requirements cannot occur. In many places at least, the capillary vessels are so closely embedded in the Haver- sian canals that they cannot dilate much ; a certain amount of serous infiltration of the bone is imaginable ; but the firm bone-substance cannot possess much capability of swelling. If the term inflamma- tion be made so general as to include every quantitative and qualita- tive disturbance of nutrition, it would be a very peculiar view, in which I do not participate. Every tissue attacked by inflammation changes its physical and chemical nature, and in acute inflammation of the soft parts this takes place rapidly; the connective tissue es- pecially is quickly changed to a gelatinous, albuminous substance ; the tissue of the cornea and cartilage may also change very quickly. For chemical reasons this is impossible in bone ; time is required for the chalky salts of the bone to dissolve, and the bone-cartilage left deli- quesces like other tissue. Hence, inflammation of compact bony tis- sue, severe though it be, cannot run its course very rapidly ; it always takes a long while. The above refers only to compact bone-substance ; spongy bones may readily become inflamed, that is, there may be in- flammation of the medulla contained in the spongy bones which has the same peculiarities as that of the long bones, only it is not collected together as it is in them, but it is distributed in the meshes of the bones ; each space contains many capillaries, connective tissue, fat-cells, and nerves ; acute inflammation of the spongy bones first oc- curs in these interspaces, and gradually extends to the bone proper. What is called acute ostitis of a spongy bone is at first only acute os- teomyelitis. This when idiopathic is rarely acute, but is usually chronic, sometimes subacute. On the other hand, there is a traumatic acute osteomyelitis of spongy bones, about which we shall here say something, although we have discussed its more important features when treating of suppuration of bone. Imagine an amputation wound close below the knee : the tibia has been sawed through its upper spongy part ; traumatic inflammation occurs in the medulla of the bone, in the meshes of the bone-substance, with proliferation oi vessels, cell-infiltration, etc. ; this leads to development of granula- tions, which grow out from the medulla and soon form a granulating surface ; this cicatrizes in the usual manner. But subsequently, if you have a chance to examine such a stump, you find that, at the sawed surface of the bone, the meshes are filled with bone-substance, and the outer layer of the spongy bone is transformed to compact bony substance ; that is, the cicatrix in the bone has ossified. This is the 308 ACUTE INFLAMMATIONS OF THE BONES, PERIOSTEUM, ETC, normal termination not only of traumatic but of spontaneous ostitis : the bony cicatrix ossifies. There may also be suppuration, putrefac- tion of the medulla of spongy bones, as in long bones ; osteophlebitis and its consequences may also occur. In the lecture on suppuration of bone (p. 216) and healing of open fractures we treated fully of the changes which occur after the bone has lost its periosteum, of the development of granulations on the surface of compact bone-sub- stance, and of the accompanying superficial necrosis. Here I will merely add that we sometimes meet multiple inflam- mations of the bones as we do multiple acute inflammations of the soft parts (acute polyarticular rheumatism) ; these may occur simul- taneously in the two corresponding bones of the lower extremities, or may follow each other; e. g., osteomyelitis of the tibia, suppura- tive inflammation of the knee-joint, osteomyelitis of the femur, puru- lent inflammation of the hip-joint ; in one case there was also osteo- myelitis of the other femur and purulent coxitis of the other side. Even such cases may possibly terminate favorably, but this is very rare; they usually end fatally. 16 We now come to acute inflammations of the joints. As we have previously spoken of traumatic articular inflammations, you already know some of the peculiarities of diseased joints. You also know that serous membranes have a great tendency to excrete fluid exu- dation when irritated, but that this exudation may also contain pus, if the inflammatory irritation be very intense. As there is a pleurisy with effusion of sero-fibrinous fluid (the ordinary form), and a variety with purulent effusion (so-called empyema), so in joints we speak of serous synovitis, or hydrops, and of purulent synovitis, or empyema ; both forms of the disease may be either acute or chronic, and they in- duce various diseases of the cartilage, bone, articular capsule, perios- teum, and surrounding muscles. You will see that it is always more complicated with these diseases the more complicated the affected part is. Of late, great importance has been attached (especially by French surgeons) to speaking, first, of diseases of the synovial mem- brane, then of those of the cartilage, articular capsule, and bone, cor- responding to the anatomical conditions. Correct as this division would be, if it were only a question of representing the pathological anatomical changes, it is of little use in practice. The surgeon al- ways views inflammation of the joint as a whole, and, although he should know which part of the joint suffers most, this is only a part of what he should know ; course, symptoms, and constitutional state, equally demand his attention, and determine the treatment. Hence the entire clinical appearance will determine the divisions of this, of many other diseases. INFLAMMATION OF THE JOINTS. 309 At present we are speaking only of apparently spontaneous acute inflammations of the joints. In many cases they are evidently due to catching cold, in other cases .their causes are obscure. Some of the more subacute cases are of metastatic nature and appear as pyaemia. But at present we shall speak only of the idiopathic inflammations, which, in contradistinction to the traumatic, are termed rheumatic, as they are often due to cold. Patients requiring your aid for such acute inflam- mations of the joints, will present somewhat different symptoms. If, for illustration, we again take the knee-joint, you will have about the following picture : A strong, otherwise healthy man has taken to bed? because for a day or two his knee has been swollen, hot, and painful ; you find this on examining the knee, you also find distinct fluctuation in the joint, and that the patella is somewhat lifted up, and always rises again if pressed down ; the skin over the joint is not red ; the patient lies with his leg stretched out in bed, has no fever, and, if you ask him, can bend and extend the knee, though with some difficulty. You here have an acute serous synovitis, or hydrops genu acutus. The anatomical condition of the knee is as follows : the synovial membrane is slightly swollen and moderately vascular ; the articular cavity full of serum, which has mingled with the synovia ; there are a few flocculi of fibrine in the fluid, the rest of the joint is healthy. Anatomically the state is just like a subacute bursitis tendinum or a moderate pleurisy. This disease is generally cured without difficulty ; quiet, re- peatedly painting with tincture of iodine, or a few blisters, or com- pression with wet bandages, suffice to remove the affection in a few days, or at least to take off its acuteness ; all the symptoms of the acute inflammation may subside, the patient may go about with scarcely any difficulty, but there remains too much fluid in the joint, a hydrops chronicus of the joint is left. You may be called to another patient with inflammation of the knee-joint. A few days previously the young man has caught cold ; soon after this his knee has begun to pain, high fever has come on, perhaps a heavy chill ; the joint has constantly grown more painful. The patient lies in bed, with the knee flexed so that the thigh is strongly rotated outward and abducted ; he resists every attempt tc move the leg, as it causes him terrible pain. The knee-joint is greatly swollen and feels hot, but there is no fluctuation, the skin is cedematous and red about the knee, the whole leg also is cedematous ; on account of the pain it is impossible to extend the knee or to flex it more. What a contrast to the former case ! If you have a chance to examine the joint in this stage, you find great swelling of the synovial mem- brane ; it is very red, puffy, and microscopically appears infiltrated with plastic matter and serum. In the joint there is usually a little 310 ACUTE INFLAMMATIONS OF THE BONES, PERIOSTEUM, ETC. flocculent pus mixed with the synovia, there may also be pure pus. The surface of the cartilage looks cloudy, and microscopically perhaps shows little change beyond turbidity of the hyaline substance ; possi- bly the cartilage cavities are somewhat enlarged and filled with an un- usual number of cells. The tissue of the articular capsule is cedematous. Here you have a purulent very acute synovitis, in which the cartilage threatens to participate ; should the disease continue, and the pus in the joint increase, you may correctly call it empyema of the joint. The difference between the first and second forms of acute syno- vitis is essentially that, in the second, the tissue of the synovial membrane is deeply affected, while in the first the increased secretion is the chief feature. Between these two forms are subacute cases, in which the secretion becomes purulent and collects in great quantity, without there being any great destruction of the synovial membrane. R. Volkmann calls this " catarrhal inflammation " of the joint ; it is somewhat more painful than ordinary acute hydrops, from which the catarrhal purulent form may proceed, though this is rarely the case. I have already said what was necessary about the course and treat- ment of acute hydrops. The course and results of the more paren- chymatous synovitis, which is predisposed to suppuration, depend greatly on when the treatment is begun and what it is. Usually a few leeches are applied and then the joint is poulticed, from an idea of the old school, that rheumatic articular inflammations should be treated with warm applications. I consider leeches almost useless in these affections ; perhaps there may be a question about keeping the limb warm, for this is often pleasant to the patient ; it alleviates the pain in inflammations of the serous membranes, often more so than cold does ; at least the latter must act for some time before having a favor- able effect. I explain this as follows : The warm applications induce fluxion to the vessels of the skin, and thus empty those of the syno- vial membrane ; but this effect is not long continued ; fluxion to the inflamed deeper parts returns again, and is stronger than to the artifi- cially-warmed skin. On application of a large bladder of ice to the joint, the vessels of the skin contract, and perhaps drive the blood to the vessels of the inflamed part more strongly than before, till gradu- ally the cold has its effect on these also, and if the cold continues the effect becomes permanent. It seems more rational always to use cold in these cases ; in very acute inflammations of the joint the employ- ment of ice-bladders has also proved very practical. Besides using cold, you may also induce active derivation to the skin by strong tinc- ture of iodine, or by a large blister. But besides these remedies it is most important io bring the joint into a proper position and keep it there, for, if we do not obtain a perfect cure, and the joint remains INFLAMMATION OF THE JOINTS. 311 stiff, the flexed position of the knee, which is so frequent, is a very un- fortunate addition to the stiffness, as it renders the limb nearly if not entirely useless. Why the acutely-diseased joint, especially in intense suppurative synovitis, almost always involuntarily assumes a flexed position, is a difficult question, which may be answered in various ways: it has been said that there is a sort of reflex action on the motor muscular nerve from the irritation of the sensory nerves of the synovial membrane, and that this is the cause of the muscular con- traction. Bonnet^ a French surgeon, who has done much for the treatment of diseases of the joints, thinks that in great distention of the joint with pus, or even by swelling of the synovial membrane, the flexed position may be caused mechanically, as the space in the joint is greater in the flexed than in the extended position ; he has tried to prove this by injecting the joints in the cadaver, and by filling them completely he has brought them into the flexed position. Against this it may be said that in hydrops acutus, where there is usually more fluid in the joint than there is in purulent synovitis, the flexion does not occur, and also that in acute inflammations, where I could satisfy myself of the non-existence of fluid, there was flexion. It seems to me that the acute, puffy, painful swelling of the synovial membrane is the chief cause of the flexion, hence I should incline to the first ex- planation, according to which the pain is the irritation that induces contraction of the muscles of the limb : other muscles also, in parts suffering from acute pain, contract, as the cervical muscles in deep- seated abscesses of the neck. The malposition should be relieved ; this should be done for each joint in such a way that in case of com- plete stiffness its position shall be most favorable. The hip and knee- joint should be extended, the foot and elbow at right angles ; the wrist and shoulder do not get out of position ; the former usually re- mains extended, the latter usually takes such a position that the arm lies against the thorax. There is very great difference in the frequency of acute disease in the different joints ; the knee is most frequently affected, then the elbow and wrist ; acute inflammation of the hip, shoulder, and ankle, is rare. Acute articular inflammations are more frequent in young persons than in old, but hardly ever occur in chil- dren. But, to return again to the improvement of the position of the joint : you will tell me this is impossible. Chloroform is here useful ; this remedy has become most important in the treatment of inflamma- tions of the joints. You narcotize the patient deeply, and can then move the limb without trouble ; the muscles, which previously con- tracted on the least touch, now yield without difficulty. If we continue with our former hypothetical case, you extend the knee, envelop it in a thick layer of wadding, and apply a plaster-splint from the foot to 312 ACUTE INFLAMMATIONS OF THE BONES, PERIOSTEUM, ETC. the middle of the thigh. When the patient awakes, he will at first complain of severe pain ; give him quarter of a grain of morphia and apply one or two bladders of ice over the plaster-splint to the knee ; the cold acts slowly, but finally proves effective, and in twenty-four hours the patient feels tolerably comfortable. The slight compression made by the well padded plaster-splint also has a favorable antiphlo- gistic action ; if there be fever, you may give cooling medicines and saline purgatives ; but the patient needs no further treatment. Be- fore applying the dressing, you may have the limb rubbed with mer- curial ointment or painted with tincture of iodine. It is best to apply the dressing even in the most acute stage ; of course it must be done very carefully, avoiding any strangulating pressure. Recently it has been shown that, even in very acute inflammations of the joints, sur- prising results may be obtained by extension with weights. It is very interesting to observe how a continued moderate traction lessens the pain in the joint and relaxes the muscles. But much depends on the application of the dressings, and I cannot too strongly urge on you to attend carefully to these apparently simple mechanical things, whose importance you will not correctly estimate till thrown on your own resources in practice, and obliged to attend to the minutest de- tails yourself. If called to the case early, you may sometimes not only arrest the acute stage of the disease, but may preserve to your patient a mov- able joint. But, even if called late, the above treatment should be pursued. If the pain is relieved and the fever ceases, you may re- move the dressing in a few weeks, for the disease lasts several weeks under any circumstances ; perhaps three to five months may elapse before the inflammation entirely disappears; gradually the normal condition and the former mobility return, then the patient should be earnestly warned against taking cold or excessive motion, for a second attack might not turn out so well. Supposing the acute process does not subside under the treatment instituted, but continues to progress, it may pass into a chronic form, or remain acute ; we shall hereafter treat of the former case. Let us at present suppose that the pain, instead of subsiding, becomes more severe, and you are obliged to split the dressing along the front ; you find the knee more swollen, distinctly fluctuating, and the patella very movable, while the patient has high fever. If the disease con- tinues, the fluctuation may extend farther and farther, upward to the thigh, for instance, and the subcutaneous cellular tissue of the thigh and leg may participate in the suppuration. Formerly this extension was attributed to subcutaneous bursting, or partial suppuration of the synovial sacs around the joint, especially of the large one under the INFLAMMATION OF THE JOINTS. 313 tendon of the quadriceps femoris, and of the bursa poplitea ; to pre- vent this misfortune it was considered advisable to tap the joint with a trocar, in the above stage of the disease, to let out most of the pus, and then carefully close the opening. From my own experience I should consider this operation as rarely indicated, for I have convinced my- self, by careful examinations of patients, and occasionally of the cadaver, that these periarticular abscesses in the cellular tissue, oc- curring in acute synovitis, and also in ostitis of the articular extremi- ties, form separately, and break into the joint late, if they do so at all. With the development of these abscesses the general condition of the patient is usually impaired ; he has high fever, with intercur- rent chills, his cheeks fall in, he emaciates, loses his appetite, and becomes sleepless. Quinine and opium finally lose their effect, and, unless you amputate the thigh early enough, the patient dies from the exhausting suppuration and continued fever; perhaps, also, he may have metastatic abscesses. If, by the applications of ice, by one or more incisions for evacuating the pus, by quinine and opium, you suc- ceed in breaking the acute stage of the disease, and making it chronic, you will not obtain a movable joint, but even if it is flexed at a right angle, the leg will be useful ; this is the best result that we can gain after days and weeks of anxiety and care, if the inflammation reaches the above grade. The anatomical changes in a knee-joint in this stage of inflammation are as follows : The joint is filled with thick yellow pus, mixed with fibrinous flocculi ; the synovial membrane is covered with dense purulent fibrous rinds, under which it is very red and pufiy, partly ulcerated ; the cartilage is partly broken down into pulp, partly necrosed and peels off; the bone under it is very red or infiltrated (osteomyelitis ; usually in these cases a secondary, rarely a primary disease). The prognosis of this disease is not very bad in young, vigorous persons, when the proper treatment is resorted to early ; it is very bad, almost absolutely fatal, in old, decrepit persons. In the above I have pictured to you typical cases of the two forms of synovitis, the serous and parenchymatous (purulent), and am satis- fied that in practice you will readily recognize these pictures again ; and you will have no difficulty in applying what has been said of the knee to other joints. Now I must add that there is still another acute or subacute form of articular inflammation, which offers some peculiarities. I refer to acute articular rheumatism. This very pe- culiar disease, which will be treated of more fully in the lectures on 314 ACUTE INFLAMMATIONS OF THE BONES, PERIOSTEUM, ETC. mternal medicine, is characterized by its attacking several joints at once, and its tendency to cause inflammations of other serous mem- branes, such as the pericardium and endocardium, the pleura, and rarely the peritonaeum and arachnoid. This simultaneous disease of these membranes and of the joints marks the affection as one impli- cating the whole body from the start ; indeed, from the importance of the organ affected, the pericarditis and endocarditis are often so prominent, and so much influence the treatment, that the surgical treatment of the joints is a very secondary matter ; this is the more apt to be the case, as this disease, although very painful, rarely proves dangerous to the limb or to life. The chief symptoms of the local affection, beyond which the disease rarely proceeds, are, great pain in the joint on every motion or touch, oedema of the surrounding soft parts, and rarely redness of the skin. From the few autopsies that have been made, it appears that the synovia increases somewhat, is sometimes mixed with flocculi of pus, and the synovial membrane is swollen and red ; the cartilage is seldom implicated ; the collection of fluid is not often so great as to cause fluctuation. Acute rheuma- tism is very frequent, but it is rarely fatal, so that the pathological anatomical appearances are little known. From all the symptoms of this disease, it is evidently a specific, limited disease, of a peculiar character, but with a course so atypical, and causes so obscure, that its actual character has not yet been determined. I have my doubts whether, besides this polyarticular^ we can speak of a monarticular acute, rheumatism^ for it is just the multiplicity of the points of inflammation, and their slight tendency to suppurate, that charac- terize the disease ; at all events, I should not consider an inflammation limited to one joint as a symptom of acute rheumatism, unless pleu- risy, pericarditis, or some other complication peculiar to rheumatism, also occurred ; should none of these come on, the disease is purely local, a simple inflammation of the joint, which is probably called rheumatic simply because it is supposed to be due to catching cold. In acute rheumatism, the resolution of the articular inflammation and the res- toration of the joint to its functions are so common that we rarely see any other termination. That the disease is tedious, and generally lasts six or eight weeks, is not so much due to the duration of the affection in a single joint as to its attacking first one joint, then an- other, aod exacerbations readily occurring in joints that had recov- ered ; thus the disease proves tedious, both for physician and patient, and the greatest watchfulness and care are necessary to avoid all sources of injury that may again arouse the disease. It is exceedingly rare for one of the affected joints to go on to intense suppuration or empyema ; more frequently, in spite of the subsidence of the disease, INFLAMMATION OF THE JOINTS. 315 a joint remains stiff and painful, and passes into a state of chronic inflammation. You see that the prognosis of this disease, as far as it concerns the joint, may be called very favorable ; without any inter- ference from the physician, the joint-inflammations generally run a favorable course. Hence all that we do for the local disease is to en- velop the joint in wadding, tow, oakum, or wool, to protect it from changes of temperature. Mild cutaneous irritants and painting with tincture of iodine may also be useful. For alleviating the pain in the joints and hastening the course of the disease, Stromeyer and others recommend the employment of bladders of ice, and generally keeping the joint cool, rather than warm. But I think this treatment will find few disciples, for it is quite troublesome, and experience shows that the articular inflammations get on well without such applications. Internally, we may give diuretics, diaphoretics, or cooling salts ; in heart-affections, local antiphlogistics, digitalis, etc., are indicated, as will be taught you more particularly in special pathologies, and in the medical clinics. Next to acute rheumatism comes acute arthritic inflammation of the joints. The attack of podagra or chiragra is also specific and belongs to true gout ; here, also, the articular inflammation is an acute serous synovitis, but with very little secretion of fluid in the joint. But one thing peculiar to acute arthritic inflammation is the never- failing coincident inflammation of the surrounding parts : the peri- osteum, sheaths of the tendons, but especially of the skin; this always reddens, becomes glistening and tense, as in erysipelas, and is very painful ; it even desquamates occasionally after the attack. Acute arthritic articular inflammation is far more painful than rheu- matic. We shall hereafter speak of the treatment of arthritis and the arthritic diathesis. There is still another variety of acute articular inflammation, the metastatic, about which we shall have something more to say when treating of pyaemia. Acute or subacute metastatic inflammation of the joint is usually at first serous, but soon purely suppurative syno- vitis. Several forms may be distinguished : 1. Gonorrhoea! inflammation of the joints. This occurs in men suffering from gonorrhoea ; occasionally, also, it occurs after the intro- duction of bougies into the urethra ; it attacks the knee-joint almost exclusively. Some authors assert that it is especially apt to develop when the gonorrhoea is arrested suddenly. This is not my own ex- perience. In proportion to the frequency of gonorrhoea, it is very rare, but I have seen it quite frequently when a patient with active 316 ACUTE INFLAMMATIONS OF THE BONES, PERIOSTEUM, ETC. gonorrhoea has caught cold. The incomprehensible connection be- tween purulent catarrh of the urethra and inflammations of the knee- joint might be denied, and the simultaneous occurrence of the two diseases be considered as accidental ; but the experience of too many surgeons, and also cases where inflammations of the knee-joint occur after other irritations of the urethra (as by bougies), speak in its favor. Gonorrhceal gonarthritis usually attacks both sides, and is a subacute serous synovitis, which generally soon disappears under proper rest, avoidance of new irritation of the urethra, blisters, tinc- ture of iodine, and slight compression of the joint ; and, after reab- sorption of the fluid, it ends in perfect cure. But irritability of the joint is apt to remain, and not unfrequently the same person getting another gonorrhoea is again attacked with inflammation of the joints. In some cases chronic articular rheumatism is said to follow gonor- rhceal gonarthritis. 2. PycBmic inflammation also occurs very frequently in one knee, as well as in the ankle, shoulder, elbow, and wrist ; rarely in the hip. It is a pure purulent synovitis, subsequently accompanied by suppu- ration of the periarticular cellular tissue, but usually with subacute course, and hence we do not always find it fully developed at the time of autopsy. Pysemic patients do not always die with suppuration of the joint, and I have witnessed reabsorption in cases where the patient lived through the purulent infection. The treatment does not differ from that above given ; if the collection of pus is excessive, puncture will relieve the pain. Suppurations of the joint due to injuries, and lacerations of the urethra by careless catheterization, and usually accompanied by chills, are of course pyaemic, not gonorrhoeal. In Berlin I treated a young man who had a rupture of the urethra caused by bougies, and consequently an abscess of the left shoulder, with suppuration of the acromial joint of the clavicle, which induced sub- luxation of that bone. The patient recovered perfectly; and, as the abscess was not large, it was not opened. A year later I saw the young man again. The abscess had become somewhat smaller, fluctuation was still distinct; but, as it caused no disturbance of function or other difficulty, and the patient was blooming and healthy, I avoided opening the abscess, and advise you to do the same with cold abscesses which evidently communicate with a joint, as the opening does little good and may do much harm, by pos- sibly inducing acute inflammation of the joint and very disagree- able results. 3. Puerperal inflammations of the joints. Puerperal fever is a torm of pyaemia that may occur after parturition. Hence, the suppu- rative inflammations of the joints occurring at that time come under INFLAMMATION OF THE JOINTS. 317 the above category of pyaamic, suppurative synovitis. But not unfre- quently, the third or fourth week after parturition, there is an acute suppurative inflammation of the knee and elbow joints, which has been referred to various causes. Some say it is a simple form of acute articular inflammation due to catching cold, to which women are par- ticularly liable after confinement, because they perspire so much. Others are of the opinion that these late inflammations of the joints are also symptoms of pyaemia that have been overlooked and are isolated, and hence consider them as metastatic. Let this be as it may, it is at all events certain that these cases have nothing specific. They run either an acute or subacute course, and, under suitable treat- ment, may be so controlled that the joint will remain movable ; but sometimes a more chronic course begins later and terminates in anchylosis. The prognosis is not very bad. They rarely reach the highest grade of acuteness. The treatment is the same as that already given for acute suppurative synovitis. I would also mention that purulent articular inflammations occur in the pyaemia of the newly-born ; children are even occasionally born with them, as has been witnessed by myself and others. Inflamma- tions of the joints may develop and even run their course during foetal life, as is shown by the cases where children are born with joints fully developed but anchylosed. APPENDIX TO CHAPTERS L-Xl RETROSPECT.— GENERAL REMARKS ON ACUTE INFLAMMA TION Gentlemen : Thus far I have given you a number of clinical sur- gical pictures representing various forms of acute inflammation. We have seen injuries and their results, as well as the acute surgical dis- eases occurring without injury, and have studied the disturbed physi- ological processes, the means of their removal, and the process of this removal. It seemed as if this method would be stimulating for you, and that it was permissible, as you were supposed to have some knowledge of general pathology and some starting-point for patho- logical, physiological, and histological investigations. Still, it will not be superfluous, at the close of this first and most extensive sec- tion of our work, to give a brief rfoume of the present views of in- flammation, which have been greatly advanced by recent labors of Cohnheim, Samuel, Arnold, and others. 318 GENERAL REMARKS ON ACUTE INFLAMMATION. I will begin by sajdng that from our ignorance of the parti cipa- tion of nerves in inflammation, we must leave them out of the ques- tion. Vessels, blood, and tissue form almost exclusively the objects of our study. Dilatation of the blood-vessels is an important factor in inflam- mation ; still, neither the hyperemia from hinderance to the current of blood in the veins (congestive hyperemia) or dilatation of the arteries from paralysis of their walls (as in the rabbit's ear after division of the cervical sympathetic), nor the sudden primary dilata- tion from mechanical and chemical irritations, necessarily leads to inflammation. About the latter form of vascular dilatation I have something to add to what has already been said. It is about the following symptom : You rub the eye, and it becomes red ; you rub the skin, and it becomes red, as it also does if you apply warm wa- ter ; you put snow on the skin, and it becomes white, then red. All of these reddenings soon pass off if their causes only acted a short time and were soon removed. The investigations mentioned in Lec- ture V. referred to the mode of origin of these hyperemias, but they are now considered unsatisfactory. The symptom itself is completely estimated by Cohnheim ; still, even under the action of heat, cold, and chemical influences, if w T e suppose a direct momentary paralysis of the vascular walls, from what we have thus far seen, it appears strange that a paralyzing influence should extend from a circum- scribed pressure or tear to an extensive portion of surrounding vas- cular territory, with a sort of wave-like motion. It seems to me we know no more about this "affluxus" to the "stimulus' 5 than we for- merly did. But it is important, as Cohnheim has shown that where inflammations occur after physical or chemical influences, these pri- mary fluxions may have passed over long before the new hyperemia which leads to and continues with the inflammation ; and the pri- mary fluxions may entirely fail, but a regular inflammation with its hyperemia nevertheless occurs. Hence the fluxion immediately fol- lowing the irritation is not an absolutely necessary factor of the inflammation. A rabbit's ear whose vessels have been paralyzed and dilated by section of the sympathetic does not inflame ; its tissue becomes more tense from oedema, but nothing more ; there is no further disturb- ance of nutrition in the vessels and tissues. Extensive congestion, however, is more serious. It has already been stated in Lecture Y. that slight increase of intravascular press- ure, such as occurs after moderate injuries, quickly passes over and has no effect on the inflammation. But if the congestion be very extensive and cannot be equalized, there is so copious an exudation CIRCULATION IN INFLAMED TISSUE. 319 of serum in the tissue (oedema) that it cannot be carried off by the lymphatics ; sometimes there is free escape of red blood-corpuscles through the walls of the capillaries into the tissues (diapedesis). Cohnheim stated it as probable that the diapedesis resulted through openings in the capillary walls. Arnold not only confirmed this, but indicated the so-called stigmata (the small openings which be- come visible between the cells forming the capillaries, after staining with silver) as the point of escape, and also showed that blood -serum flowed out through these stigmata. If the hinderance to the circu- lation be of such a nature that blood can continue to flow, the only results will be oedema and diapedesis ; if the circulation be entirely arrested, gangrene results. Coming at last to hyperemia as it occurs in inflammation, it is neither the immediate result of temporary inflammation, nor of paral- ysis of the vaso-motor nerves, nor of obstruction to the circulation, but of a peculiar alteration of the walls of the vessels, especially of the capillaries and veins. What chemical or physical changes occur at the same time in the walls of the vessels cannot be stated ; but we conclude that the vessels in the inflamed part are permanently dilated, and permit the free escape of white blood-corpuscles (not only at the stigmata, but at any point in their walls), and that the substance of these vessels is softened and more yielding. Why this is so, certainly cannot be determined in all cases ; it is considered as a direct effect of the cause of the inflammation, though it does not occur for some hours. The inflamed borders and areolae around sharply-bordered cuts or stabs are just as difficult to explain as the primary fluxions. We must even involuntarily suppose that a dis- turbance can never be accurately confined to the part supplied by a certain vessel, but that it must spread somewhat, least so in cuts, stabs, or rapid burns, and most so after certain chemical actions. Still, this is no true explanation ; it is merely a limitation of obser- vation. Let us now consider the blood and its circulation in inflamed tissue. Primary fluxion is accompanied by greatly increased ac- tivity of the movement of the blood, especially in the arteries, which again becomes normal as the primary dilatation of the vessels recedes. In the vessels which dilate permanently, in the borders and areola of the inflammation, the rapidity of the circulation grad- ually diminishes, especially in the veins ; the blood may move by impulses, or occasionally stop completely. This stasis, which is not at once accompanied by coagulation of the blood, was formerly re- garded as a necessary part of true inflammation, and had many expla- nations, which hardly interest us now, as we know that many inflam- 320 GENERAL REMARKS ON ACUTE INFLAMMATION. mations run their course without stasis, as well as that this stasis often disappears in spite of progressing inflammation. If it contin- ues, the blood finally coagulates in the vessel (thrombosis), the results of which vary with local conditions and the extent ; there may be a return to the normal state by collateral dilatation, or gangrene may result. The circulation in the inflamed part is at first slow and ir- regular, and again becomes normal. Meantime numerous white blood-cells collect along the walls of the small veins and capillaries ; then they wander through the walls of the vessels into the tissues, whose interstices become filled (cellular, or, if excessive, purulent infiltration) ; and finally they reach the surface (superficial suppura- tion, purulent catarrh). We have now the complete picture of acute inflammation ; but the process may recede at the time of dilatation of the vessels and arrest of the white blood-cells, and even subsequently, when cellular infiltration has advanced quite far, without leaving any change per- ceptible in the tissue that has been infiltrated or the vessels which have been dilated. But at a certain height of the purulent inGltra- tion the tissue disappears entirely, and is replaced by pus (an ab- scess forms), or by an interstitial neoplasia (granulation tissue), which, if it does not die, becomes connective tissue (cicatrix), with vessels and nerves. The question arises, What causes this atrophy of inflamed tissue ? Is it the direct effect of the cause of the inflammation or of the cellu- lar infiltration ? Here we come to the third important point in in- flammation, namely, the part taken by the tissue itself. If we first consider the inflammations caused by known chemical or physical causes, it is evident they cannot act on the vessels and blood with- out at the same time affecting the tissue. Samuel starts from the inflammation induced by chemical means, and explains it as a result- ant of the union of the cause of the inflammation with the tissue, the walls of the blood-vessels and the blood. The wandering of the blood-cells, their infiltration in the tissue, and the accompanying changes, he regards as secondary processes. If the action of concen- trated sulphuric acid on the tissue causes such a metamorphosis that circulation of blood and other fluids is no longer possible, the tissue is directly killed ; but the most essential thing in the inflammation is the change of tissue affected by dilute sulphuric acid (whether at the borders of a part cauterized by strong acid or where only dilute acid was used), where circulation still continues. According to this, if I have rightly understood SamueVs explanation, the disturbance in the inflamed tissue would vary in different cases, according as the active cause was an acid, an alkali, ethereal oil (as oil of turpen- DILATATION OF VEINS AND CAPILLARIES. 32 1 tine), or an acrid oil (as croton-oil), etc. The condition of the in- flamed tissue would differ also with action of extreme cold, great heat, crushing, after steam on exposed surfaces or serous membranes, etc. So we should have to renounce entirely a uniform representation of the chemical processes in the inflamed tissue. I do not know if this view will ever prove popular in this form. Hitherto we have classed these changes of tissue at the seat of inflammation all to- gether ; just as by concussion of the brain we should mean not only the moment of concussion, but also its immediate effect on the brain and its functions. If the concussion be followed by inflammation of the brain, the changes caused by the concussion may influence the nature and extent of the inflammation; but we do not say that a brain suffering from concussion is already inflamed. The same is true of contusions : if the normal function of a tissue has been af- fected by a concussion, but its function not entirely destroyed, the circulation will differ from normal, and this modification we call in- flammation, but do not so term the immediate result of the contu- sion. The processes in the tissues, after chemical, physical, or me- chanical injuries, are essentially similar, differing only in extent and intensity ; they are what we term inflammation, and in it the tissue itself plays an important part, which varies with the way the cause has directly affected the tissue. A constant perceptible result of acute inflammation is dilatation of the veins and capillaries, with escape of white blood-cells and cer- tain disturbances of the physiological functions of the affected tissue. For all this to occur, one function of the vessels, especially that of the cellular elements of keeping the blood in the channels formed by them, must be disturbed ; but would such a disturbance be confined to the walls of the vessels, and not extend to the adjacent tissue ? This is not very probable. The granular cloudiness occurring in in- flamed muscle, the indistinctness of the filaments in inflamed con- nective tissue, the granular disintegration in inflamed nerve-filaments, the rapid loss of color of red blood-cells in acutely inflamed tissue, all indicate that certain constant changes go on in the tissue also, which usually lead to gradual solution or death of the tissues, unless gangrene occurs from rapid increase of the process. I acknowledge there is no proof that these changes begin simultaneously with those in the vessels, and that they may be regarded as an immediate re- sult of the latter ; for if we find these alterations of tissue without dilatation of the vessels and cell-emigration, or if we artificially cause this state by obstructing the circulation to the injured part {Samuel), there may be a doubt as to whether it is to be termed inflammation in the ordinary sense ( Cohnheim). But, on the other hand, at- 21 322 GENERAL EEMARKS ON ACUTE INFLAMMATION. tempts have been made to distinguish the changed condition of the vessels which permits the extensive escape of white blood-cells from inflammation. When studying chronic inflammation, we shall see that all of these factors can occur separately, and that it is only their combination which forms what we call inflammation. Virchow located the inflammatory disturbances chiefly in the tissue ; he was led to this partly by the microscopic changes just mentioned, partly from the observation that on irritation young cells appeared even in non-vascular tissues, like the cornea and car- tilage, just as .they do in vascular tissues. These latter observa- tions, which were made at a time when the emigration of white blood-cells was not understood, can now be differently interpreted (Lecture VI.). We doubt now just as little as formerly that carti- lage-cells and some others, as certain endothelia of serous membranes (JRindfleisch, Kundr at), young epithelial cells (JRemak, JBuhl, Rind- fleisch), etc., on being irritated in a certain way, will form new pro- toplasm and new cells in themselves, will divide up, and may thus lead to formation of new tissue. It is still doubtful whether all cells thus formed have independent movements, like pus-cells ; but very few observers now believe that developed connective tissue, corneal or bone corpuscles, acquire this peculiarity; it is pretty gen- erally recognized that formation of pus does not result from local proliferation of fixed connective-tissue cells, according to VircJiovfs theory. Many regard it as still undecided how much the wandering cells have to do with inflammatory new formations ; from my obser- vations I can hardly doubt that the tissue which causes healing by first intention, as well as granulation tissue, may proceed from wan- dering cells, although another mode is possible (by offshoots, direct outgrowth from the tissue, Lecture VI.). The transformation of wandering cells into connective tissue seems to me quite plausible, for, according to my investigations, they probably originated from connective-tissue cells, namely, from the stellate cells, filaments of lymphatic glands. Of late, attempts have been made to explain why the above-mentioned tissue-cells, such as cartilage-cells, after certain irritations, begin to enlarge, divide, and finally to produce new tis- sue, by the hypothesis that every protoplasm, supplied with proper nourishment, would grow and divide up if not hindered by the press- ure of the tissue in which it develops ; the partial escape of the nu- cleus, as from injury or increased distensibility of the tissue, the nutritive conditions being otherwise good, is said to be enough to start the remains of the cell into growth. This hypothesis, which was advanced by Thiersch for another object, and which has been warmly taken up and generalized by Samuel, seems very ingenious, FORMATION OF FIBRINE. 323 and I think it may prove the fruitful basis of future observations. But tissue-development is dependent on other important factors be- sides the conditions of nutrition and pressure, as on inherited pecu- liarities of the protoplasm ; and the above hypothesis does not suit all cases — for instance, the endogenous cell-development of the endo- thelium after inflammatory irritation of the peritoneum. It is not known whether there is a primary disturbance of nutri- tion in the tissues themselves, independent of the blood-vessels and their functions, that induces the specific inflammatory alteration in the vessels. The deposit of urates in the tissue of certain parts of the body in arthritis is usually regarded as of this nature ; but the deposit requires participation of the vessels, and so they and the tissues are simultaneously affected. An experiment of Cohnheim shows that continued exclusion of blood from a blood-vessel may so affect its walls that when the blood again enters there will be a free emigration of white blood-cells. It was mentioned above that con- tinued stasis of the blood did not have this effect on the walls of the vessel where it was stagnated ; but from clinical grounds it is prob- able that the pressure of extensively and rapidly distended vessels on the parts around has something to do with their inflammation. It is very probable that inflammations may be induced not only by chemical, physical, and mechanical causes, which act from with- out directly on certain parts of the body, but also by primary disturb- ances of nutrition in the tissues and of the circulation, which develop in the body without perceptible cause. I must not forget to mention one symptom which formerly played • a great role in inflammation, but is now hardly mentioned ; that is, the formation of fibrine in some inflammations. This occurs chiefly, indeed almost exclusively, in inflammation of the connective tissue, and sometimes on the surface of serous sacs, of fresh and granulat- ing wounds, and of mucous membranes (of pharynx, larynx, and bronchi) ; in other cases the nutrient fluid in the connective tissue assumes a fibrinous rigidity. It has been already mentioned that the formation of fibrine is not from an excess of fibrine in the blood, but from chemical alteration in the inflamed parts. Fibrine forms in the inflamed tissue, but is not a constant result of inflammation. The great difference of the other symptoms occurring with fibrinous inflammations is remarkable. While rapid formation of a moderate amount of fibrine favors healing by the first intention and partial adhesion of the surfaces of serous membranes, when often scarcely a trace of inflammation or fever is perceptible, in other cases, from some enigmatical cause, a very moderate fibrinous deposit in the tissues (as fibrinous deposit on the mucous membrane of the throat, 324 GENERAL REMARKS ON ACUTE INFLAMMATION. diphtheria) causes death. It is very evident that fibrinous harden- ing of the tissue fluids is one of the severest alterations of their nu- trition ; and, as experience shows, it often ends in necrosis. Still, the severe general symptoms and extensive inflammatory redness in these processes cannot be due simply to the formation of fibrine, but seem referable to absorption of the products of decomposition in the diseased tissue, which has a very rapid poisonous action. In the acute inflammations with formation of fibrine there seems to be a scale of malignancy similar to those without such formation, so that this would seem to be rather an accident due to the variety of the tissue and its locality ; and while its significance is very important, it is not essential to the inflammation, nor does it materially change the course. The serous transudation also, which accompanies acute inflam- mations, deserves a short notice. In many cases it certainly is the result of change of pressure in the vessels at the seat of inflamma- tion ; but it is just as much due to impaired function of the walls of the vessels and of the tissue ; it is often a prominent symptom in inflammations of the connective tissue, especially of serous mem- branes. The walls of the vessels cannot hold the serum of the blood ; the tissue does not prepare it ; veins and lymphatics do not carry it away, especially if they are covered and stopped up by fibrine (in inflammation of serous surfaces on which the lymphatics open). The serum in acutely inflamed tissue is essentially different from that which, without inflammation, causes dropsy, for it not only contains wandering cells and disintegrated red blood- cells, but also the soluble products of the inflammation. The removal of this fluid by the veins and lymphatics releases the tissues from a consid- erable pressure and carries off the injurious products, it is true ; but part of it at least is carried into the blood, and probably causes the inflammatory fever. This has already been fully treated of. Now we might speak of the causes why circumscribed and often purely mechanical irritations, acting on small portions of the body, occasionally excite such intense spreading inflammations, and of the way these spread. But I will not now trouble you further with this subject. I have already said something about it in Lecture XXI., and shall hereafter have occasion to say more. Pathological anatomists have paid too little attention to these questions ; surgeons see their importance too often, and seek in vain for a means to arrest these spreading inflammations. In the clinic there will be many opportunities to call your attention to these important points. It is in the nature of our times to undervalue the significance VALUE OF THEORETICAL REFLECTIONS. 325 and practical value of these so-called theoretical reflections with which I have perhaps fatigued some of you. But hereafter, when you have been in practice for some years, you will hardly be able to read and understand a medical work if, during your student-life, you have not acquired a basis on which to build. After some years of practice some of you, who are now sated with lectures, will long to hear a continuous scientific exposition of important morbid pro- cesses. CHAPTER XII. GANGRENE LECTURE XXIII. Dry, Moist Gangrene.— Immediate Causes.— Process of Detachment. — Varieties of Gan- grene according to the Eemote Causes.— 1. Loss of Vitality of the Tissue from Mechanical or Chemical Causes. — 2. Complete Arrest of the Afflux and Efflux of Blood. — Incarceration. — Continued Pressure. — Decubitus. — Great Tension of the Tissue. — 3. Complete Arrest of the Supply of Arterial Blood. — Gangrena Spon- tanea.— Gangrena Senilis. — Ergotism. — L Noma.— Gangrene in Various Blood- Diseases. — Treatment. We have already spoken frequently of gangrene and mortification. You know in general what they mean, and have already encountered a series of cases where there was local death of a part ; but there are many other circumstances, with which you are not yet acquainted, which favor gangrene ; all of which we shall include in this chapter. You already know the word gangrene to be perfectly synonymous with mortification. Originally it was only used to express the stage where the dying part was still hot and painful ; that is, not completely dead. This was called " hot mortification," while the moist " cold mortification " was called by the old authors sphacelus. The word mummification is also employed for dry gangrene. From the moment the circulation ceases, moist gangrene is perfectly analogous to ordi- nary putrefaction. Although it cannot always be certainly stated why dry gangrene occurs in one case and moist in another, we say gener- ally that when the circulation ceases suddenly, especially if the parts have been previously inflamed or ©edematous, moist gangrene occurs. Dry gangrene — mummification or shrinking of the parts — is more fre- quently due to gradual death, where the circulation has continued jceebly in the deeper parts, and the serum has been carried off from the gradually-dying parts by the lymphatic vessels and veins. Rapid evaporation of the fluid also induces gradual dryness. It is certainly CAUSES OF GANGRENE. 327 true that even in moist gangrene a superficial dryness of the skin may occasionally be obtained by removing the hard layer of the epidermis, which readily peels off from the decomposing limb ; we may also greatly favor the drying by applications of substances having a strong affinity for water, such as alcohol, solutions of corrosive sublimate, sulphuric acid, etc. ; but we cannot obtain so complete a mummifica- tion as sometimes occurs spontaneously. Hence, dry gangrene is not a simple putrefaction, but a rather complicated process, which gradu- ally leads to arrest of the circulation. The immediate cause of death of individual parts of the body is always the complete cessation of the supply of nutriment consequent on arrest of circulation in the capillaries ; under some circumstances the chief arteries or veins of an extremity may be locally obstructed, and, nevertheless, the blood finds its way by neighboring branches into their lower or upper parts. Hence, obstruction of an artery can only be the immediate cause of gangrene when collateral circulation is impossible. This may be due partly to anatomical conditions, partly to great rigidity of the walls of small arteries, partly to very exten- sive destruction of the walls of the artery, as when the femoral is obstructed from the bend of the leg to the foot, the nutrition only ceases when the capillary circulation is rendered impossible by these circumstances. But it is not always necessary that cessation of cir- culation in a small capillary district, or in the parts supplied by one small artery, should cause actual decomposition ; under such circum- stances the disturbance of nutrition may assume a milder form, espe- cially when this limited disturbance of circulation comes on slowly and gradually. In this case there is molecular disintegration of tissue, which shrinks and dries to a yellow cheesy mass, in short, there is a series of metamorphoses which in the cadaver appear as dry, yellow infarctions ; this is essentially merely a sort of dry gangrene limited to a small spot. If this disturbance of nutrition and molecular disin- tegration of tissue take place on a surface, we call it ulceration / the whole series of so-called atonic ulcers, to which we shall hereafter return, are mostly due to such quantitative disturbances of nutrition. Hence, intimate as is the connection between the causes of dry gan- grene and ulceration, still, the various forms of gangrene are well marked and peculiar, as you will see from what follows, as there is generally not only molecular disintegration of tissue, but death of whole shreds of tissue, or even of an entire limb. A priori^ it is cer- tainly supposable that complete closure of all the veins returning olood from a limb, should induce complete stasis in the capillaries ; but in practice this is very unlikely to occur, for the veins are so very numerous, and in almost all parts of the body there are two ways for 328 GANGRENE. the return of blood, viz., the deep and subcutaneous veins, which communicate freely ; if one way be closed, the other will be at least partly open. When dry gangrene occurs in the skin and deeper soft parts, they usually assume a grayish-black, then a coal-black hue. In cases where the parts were previously inflamed, the skin appears at first dark violet, then whitish yellow, it only becomes brownish or grayish black in case of partial drying ; dead tendons and fascia? change their, color little. When, from disturbance of the circulation, a considerable portion of tissue ceases to be nourished, the border be- tween dead and living regularly becomes more distinctly marked ; around the dead skin there forms a bright-red line, the so-called line of demarcation. This redness is caused by distention of the capillary vessels, which is partly due to collateral circulation in them, partly to fluxion induced by the decomposing fluids, and exactly resembles the redness around the edges of a wound with loss of substance, especially of a contused wound, as we have already explained. Along with these changes in the vessels there is an active cell-infiltration in the line of demarcation, by which the tissue, whatever its nature may be, is partly softened and dissolved. All over the borders of the living tissue young cells in the form of pus appear in place of the firm tissue, and then the coherence of the parts ceases. The dead becomes de- tached from the living, and on the borders of the latter there is a layer of tissue changed by infiltration of plastic matter and ectasia of the vessels, granulations. To express this simply in surgical language we say : The dead tissue must be thrown off from the living by free sup- puration, and this detachment of the dead tissue is followed by active granulations which cicatrize in the usual manner. This process repeats itself in all tissues, in all forms of gangrene, sometimes quicker, some- times more slowly, in exactly the same way, even in bones, as you know from the necrosis of the ends of the bone in open fractures. But we shall not here treat of gangrene of bones, as it is so intimately connected with their other chronic diseases that we shall have to speak of it when treating of them. The time required for the detachment of the dead tissue may vary greatly. It depends : 1. On the size of the dead portion ; 2. On the vascularity and consistence of the tissue ; 3. On the strength and vitality of the patient. As gangrene is usually the result of other diseases, it is not always easy to correctly group the sj^mptoms which are to be referred to it. If the line of demarcation has formed, and the process of detachment is going on, an effect on the general health is apparent when the gangrene affects large extremities. Then there is a general marasmus, a gradual loss of strength, depression of the bodily temperature, small pulse, dry tongue, a half-soporose state in which the patient grows DECUBITUS. 329 weaker and weaker, and finally dies, without our being able to dis- cover in the cadaver any particular cause of death, although in other cases putrid metastatic abscesses are found in the lungs. These cases are one form of chronic septicaemia ; I have no doubt that the repeated absorption of putrid matters, during the development of gangrene, by the blood and lymphatic circulation winch partly continues, may be the cause of death. I propose to return to this question in the next section. After these general remarks, we must study more carefully the different varieties of gangrene, according to their remote and proxi- mate causes, and their practical importance : 1. Complete loss of vitality of the tissue through mechanical or chemical action, such as crushing, contusing, great heat or cold, caus- tic acids and alkalies, continued contact with ammoniacal urine, with carbunculous poison, poisons from certain serpents, putrid matters that act as ferments, etc., come under this head. We have already spoken of some of these varieties ; we shall shortly come to others of them. 2. Complete arrest of the circulation, by circular compression or other mechanical cause, is in many cases the cause of capillary stasis and gangrene. For instance, if you surround a limb firmly with a bandage, you will have, first, venous congestion, then oedema, and finally, gangrene. • Let us take a practical example : if the prepuce be too small and be forcibly drawn back over the glans so as to cause a paraphimosis, the compressed glans, or in this case more frequently the compressing ring, becomes gangrenous. The mortifi- cation of strangulated hernia depends on the same cause. Continued pressure also, by arresting the afflux and efflux of blood, may lead to gangrene, especially in persons in whom the heart's action is weakened by long disease, or who by general septic intoxication are already disposed to gangrene. Decubitus, the so-called bed-sore, is such a gangrene caused by continued pressure, but all sorts of bed-sores are not gangrenous from the first, for in some cases they are rather to be compared to a gradual maceration of the epidermis and cutis, as a result of con- tinually lying in a bed wet with sweat, urine, and other liquids. De- cubitus is particularly frequent over the sacrum, and may there attain a fearful size, all the soft parts becoming gangrenous down to the bone ; it may also occur over the heel, the trochanters of the femur, head of the fibula, scapula, or spinous processes of the vertebras, ac- cording to the position of the patient. The same thing may be caused by badly-applied dressings. This disease is the more unpleasant, as it usually comes during other exhausting affections. Although no 330 GANGRENE. disease in which the patient is condemned to long, absolute quiet, is entirely exempt from the disagreeable accompaniment of a decubitus, still some peculiarly dispose to it, chief among which- is typhus ; in patients with septicaemia, decubitus occurs very early, often even after three to five days of quiet ; it usually begins with a very circumscribed congestion of the skin over the sacrum, while, with proper care, con- sumptive patients keep their beds for months or years, without having bed-sores. This disease is particularly troublesome for the patient, because, especially in chronic maladies, it may be accompanied by great pain ; in acute cases of typhus and septicaemia, on the contrary, the patients sometimes do not feel it at all when they have a very large bed-sore. This form of gangrene is particularly dangerous when the exciting causes cannot be entirely removed, and it becomes progressive ; the prognosis is worse the more exhausted the patient ; not unfrequently bed-sore is the cause of death, as it continues to enlarge in spite of all treatment, or it may be the origin of a fatal pyaemia. Too great tension of the tissue, causing great distention of the vessels, and compressing some of them, induces, on the one hand, a diminished amount of blood, while the pathological requirements of nutriment are increased ; on the other, a coagulation of blood in the capillaries from the increased friction. This is the cause of gangrene occurring in inflammation, and which we have' already mentioned when speaking of phlegmon, but it must not be said that every stasis of the blood in the capillaries that may occasionally occur in inflam- mation is to be referred to great tension of the tissues, as there are also other causes. It would lead me too far to enter on theories, especially as you have already heard them in the course on general pathology." Moreover, we shall return to this when treating of throm- bosis of the veins. 3. Complete arrest of the supply of arterial blood, which is particu- larly due to diseases of the heart and arteries, must also sometimes lead to gangrene; in this class belong those cases of gangrene called gangrcena spontanea, or oftener gangrmna senilis, from its more frequent occurrence in old persons ; this may come in various ways and forms. The causes may vary thus: The coagulation of blood may begin in the capillaries (marasmic thrombosis as a result of debility of the heart, or insufficient conduction through the smaller arteries), or as an independent thrombus of the artery, or, lastly, a thrombus from embolism ; excessive, continued anaemia also, with great consecutive contraction of the arteries and debility of the heart, and, lastly, continued spasmodic contraction of the arteries, ma} 7 - in- duce gangrene. Gangraena senilis proper is a disease originally oc- GANGILENA SENILIS. 33 1 curring in the toes, rarely in the fingers, as I once saw. There are two chief forms: in one of them a brown spot forms on one toe ; it soon becomes black, and gradually spreads till the whole toe becomes completely dry. In favorable cases a line of demarcation forms at the phalango-metatarsal articulation, the toe falls off, and the wound cicatrizes. But the mummification may go higher and limit itself in the middle of the foot, above the malleoli, in the middle of the leg, or just below the knee. In another series of cases, the disease be- gins with symptoms of inflammation, cedematous swelling of the toes, very great pain, and dark, bluish-red color, which subsequently be- comes black ; there are stages of the disease where, by the bluish-red, mottled appearance of the skin, we may see that in one place the cir- culation is carried on with the greatest difficulty, while elsewhere it has already ceased ; this struggle between life and death the French have not inaptly compared to death by asphyxia, and termed asphyxia locale. In this form of moist, hot gangrene, the disease usually attacks several toes at once, and extends to the foot, till in the course of a few weeks the entire foot, perhaps also the leg, becomes gangrenous ; at the same time decomposition soon begins in the cedematous sub- cutaneous cellular tissue, and the danger of absorption of putrid mat- ter through the lymphatic vessels is much greater than in the process of mummification. The seat of the disease of the arteries that leads to spontaneous gangrene varies ; in acute (marasmic) gangrwna senilis, the primary coagulation due to feeble circulation occurs in the capil- laries and thence extends backward to the arteries. The feebleness of the arterial circulation may be due to various causes : 1. To di- minished energy of the heart's action ; 2. To thickening of the walls of the arteries and contraction of their calibre ; 3. To degeneration of the muscular coat of the smaller arteries. In some cases all of these causes unite, for, in old persons with feeble heart-action, diseases of the arteries are the most frequent ; besides, affections of the heart and arteries usually have a common constitutional cause. This is not the place to discuss extensively how far rigidity and atheroma of the coats of the artery are to be referred to inflammation, or to be re- garded as a peculiar disease ; nor can I permit myself to discuss further the distinctions of the finer histological points, of which we shall have something to say when treating of aneurisms, but will simply mention that in old persons the coats of the arteries are often thickened, and deposits of chalk form in them to such an extent that the whole artery is calcified and the calibre considerably dimininished by the thickening of the walls, and the inner surface becomes rough, so as to dispose to the fixation of blood-clots. The original qualities of the arteries are thus lost to such an extent that they are neither 332 GANGRENE. elastic nor contractile, and hence, partly from the diminished calibre, partly from the lack of contractility, the onward movement of the blood, already moved less forcibly on account of the feeble action of the heart, is very much impeded, so that it is easy to understand how coagulation occurs in such cases, especially in parts distant from the heart. While the cases just described are with some justice termed senile gangrene, and their connection with arterial diseases has been gen- erally recognized since the time of Dupuytren, there is another form of spontaneous gangrene, which occurs in old persons, but is distin- guished from the above, because a large portion of an extremity, as of the leg as high as the calf or the knee, becomes gangrenous at once This takes place as follows : In the chief artery, say the femoral, along the thigh or in the hollow of the knee, a firm clot forms and adheres to the wall of the vessel by rough prominences on the internal coat, due to precedent atheromatous disease, or else forms in sac-like dila- tations of the artery and gradually grows by apposition of new fibrine, so as not only to fill the calibre of the artery, but to plug up the whole peripheral end of the vessel, and even a portion of the central end, by the fibrinous clot. The consequence of this stoppage of the artery by a thrombus developing on the wall, which gradually arrests the col- lateral circulation also, is usually gangrene of the whole foot and part of the leg, which is dry or moist according to the rapidity with which the clot has developed ; it is occasionally possible to trace the growth of the thrombus by the spread of the gangrene. Not long since I observed an old man, who was taken into the hospital for spontaneous gangrene of the foot. He was so thin and the arteries were so rigid that the pulsations of the femoral could be distinctly followed into the hollow of the knee. Subsequently the gangrene progressed, and at the same time the pulsation in the lower part of the artery ceased. About a fortnight later, shortly before death, when the gangrene had advanced to the knee-joint, the pulsation had ceased at Poupart's liga- ment. The autopsy confirmed the diagnosis of complete arterial thrombosis. The gangrenous leg was so completely mummified that I cut it from the body, and, to preserve it from further destruction and worms, varnished it. It is still in the surgical museum at Zurich. Another case of arterial thrombosis is where the primary stoppage of the artery is caused by an embolus. A clot of fibrine, in endocarditis or detached from an aneurismal sac, may become wedged in an artery of one of the extremities ; this induces further deposit of fibrine. Of late, there is a tendency to refer most cases of softening and desiccation, as of the brain, spleen, etc., to such emboli. In our clinic we saw a very interesting typical case of this variety. Six weeks after confine- ERGOTISM. 333 ment, a young woman had great swelling of the left leg, which was soon followed by a dark-blue color of the skin, and complete putrefac- tion of that part of the body ; there was general septic poisoning when the patient entered the hospital. As there was no excessive anaemia, and no disease of the arteries could be discovered, I made the diagnosis of endocarditis with fibrinous vegetations on the mitral valve, and detachment of one of these vegetations, with its lodgment at the bifurcation of the left popliteal artery. I held to this diagnosis, al- though no abnormal murmur could be discovered, for it is well known that some cases of endocarditis run their course almost without symp- toms ; the rapid putrefaction of the leg must have had a sudden cause. As no line of demarcation formed, and the general condition daily became worse, we could have no hopes of saving life by amputating ; death took place about twelve days after the first symptoms of gan- grene ; the autopsy fully confirmed the diagnosis. It seems remark- able that no collateral circulation should develop in such cases, as it does after ligation of the femoral artery. I can only explain this on the supposition that in endocarditis the heart's action is weakened, and consequently the pressure of the blood is insufficient to dilate the smaller collateral arteries. Yery rare are the cases where from excessive anaemia the arteries are so much contracted that but little blood circulates through the smaller ones, and the nervous excitation of the heart is so slight that its contractions are incomplete. Cases of spontaneous gangrene from this cause are more frequent in slender chlorotic females than in men ; the patients, who are generally young, often suffer from rigidity of the hands and feet, fainting-fits, and fatigue. This disease appears to be more frequent in France than in Germany or England. There is an excellent work on the subject by Raynaud r , entitled " De Pasphyxie locale et de la gangrene symetrique des extremites," 1862. As im- plied by the title, the gangrene is usually symmetrical in the two limbs. I have only seen one such case ; a young, very anaemic man, without any apparent cause, had first gangrene of the tip of the nose, then of both feet. After suffering for months, he died ; as on the pa- tient, so on the cadaver, I could find nothing morbid beyond the ex- cessive, inexplicable anaemia. The form of gangrene seen from eating spurred rye is referred to permanent spasmodic contraction of the smaller arteries ; experience shows that this substance induces contraction of the organic muscular fibres, especially of those of the uterus, and it is supposed of the uterine arteries also. Spurred rye, secale cornutum, is a diseased grain growing in the ear of rye (secale cereale), in which is developed a peculiar material, 334 GANGRENE. ergotin. If bread be made from such grain, persons eating it are affected with peculiar symptoms, which are comprised under the name ergotismus or raphania. As the above disease of the grain is usually limited to certain regions, it may be readily understood that the dis- ease should occur epidemically in men and beasts. It has been known for a long time, but the first accurate descriptions are of an epidemic in France in 1630. The disease seems to have occurred rarely in Germany, England, or Italy. Of late it hardly ever occurs, probably because the diseased grain is better known and is no longer used for food, and because less of the grain is grown since potatoes have come into common use. From former descriptions, various forms and courses of the disease may be distinguished, of which sometimes one and sometimes another prevailed in the different epidemics ; possibly the poison is not always the same, or is at least of variable intensity. In the acute cases, the patients were soon attacked with severe gen- eral cramps, and death resulted in from four to eight days ; cramps only occur occasionally ; at the same time, and previously in the pro- dromal stage, there are great itching and crawling in the skin, but par- ticularly in the hands ; there is also a feeling of deafness, of anaesthe- sia in the ends of the fingers, rarely moist gangrene of the skin, then of whole extremities. In more chronic cases, the result is usually favorable, although several fingers or toes may be lost. 4. We have still to speak of several forms of gangrene whose causes are not exactly known, in which probably several influences unite. Among these is so-called water-canker, noma, a spontaneous gangrene of the cheeks, especially common in children, which is most frequent in cities along the Baltic, and more rare inland. Very puny children, living in cold, damp dwellings, are particularly prone to this disease, in which, without any known cause, a gangrenous nodule forms in the middle of the cheek or lip and spreads rapidly till the child finally dies of exhaustion. It is doubtful whether this is due to anaemia with feebleness of the heart, to miasmatic influence, or to some peculiar disease of the blood. In occasional remarks about septi- caemia, we have already stated that certain morbid states of the blood predispose to gangrene. Under this cause we must class the cases occurring after typhus, intermittent and exanthematous fevers, in diabetes mellitus, morbus Brightii, etc. After and during these dis- eases, gangrene of the tip of the nose, of the ear, cheeks, hands, and feet, occurs ; and in rare cases an exanthema of the skin may pass into gangrene. In such cases we may consider that the miasma which has induced the constitutional disease also influences the occurrence of the gangrene ; and, on the other side, there seems reason for the idea that these cases are mostly the result of feeble action of the heart. TREATMENT OF GANGRENE. 335 induced by the long illness, which proves insufficient to carry the blood to the remote parts of the body with sufficient energy ; accord- ing to this view, this gangrene would be due to marasmic capillary thrombosis. Doubtless various circumstances act more or less promi- nently in individual cases, so that no definite etiology can be given for these rare forms of gangrene from internal causes. I may also mention that stomatitis, from excessive use of mercury, also has a great tendency to gangrene. We shall hereafter speak of a peculiar form of gangrene of wounds, the so-called hospital gangrene}' 1 There are certain important prophylactic rules for the prevention of gangrene, especially of decubitus and other forms due to pressure ; even gangrene from inflammation may sometimes be prevented, by re- lieving the great tension of the tissue and the venous congestion by an incision made at the proper time. Be constantly on your guard against bed-sores in all diseases at all disposed to decubitus ; turn your attention to this point early : a well-stuffed horse-hair mattress is the best sick-bed ; the sheets placed over it should always be kept smooth, so that the patient shall not lie on wrinkles. As soon as any redness appears over the sacrum, you should be doubly careful about the passages of urine and feces, so that the bed may not be wet. Let a lemon be cut and the reddened spot rubbed daily with the fresh juice from the cut surface. If there be excoriation over the sacrum, place the patient on a ring cushion, or, if possible, on a caoutchouc, air, or water cushion. The excoriation may be painted with nitrate of silver, or covered with leather spread with lead-plaster. If the decubitus be gangrenous from the first, and this begins to extend, we should resort to the ordinary treatment of gangrene, of which we shall speak pres- ently. The local treatment of gangrene has two chief objects : 1. To pro- mote detachment of the gangrenous parts by exciting active suppura- tion, which is accompanied by arrest of the gangrene ; 2. To prevent the gangrenous parts decomposing, and thus acting injuriously on the patient, and infecting the chamber too much. For the first indication, moist warmth in the form of cataplasms was formerly employed. But I cannot find that they are peculiarly efficacious in these cases. If the gangrene be moist and the gangre- nous parts are much inclined to decompose, this would only be favored by the application of cataplasms ; for the detachment of a dry eschar, which does not smell badly, and when the line of demarcation is al- ready formed, it is hardly worth while to hasten the process a little by warmth. Hence I prefer covering the gangrenous parts and the 336 GANGRENE. borders of the healthy tissue with compresses or charpie, soaked in chlorine-water, and thus in moist gangrene I also diminish the bad smell of the decomposing substances. For the same purpose, we may use creosote-water or carbolic acid, or dilute purified pyroligneous acid, very strong alcohol, spirits of camphor, or oil of turpentine. Charcoal-powder absorbs the gases from the decomposing substances, but, as it soils the parts very much, it is perhaps too little used. Other powerful antiseptics are acetate of alumina (alum 3 v, plumbum aceti- cum, J j> aqua, g> 1), and coal-tar with plaster ; both remedies are very serviceable, but, like all similar ones, must be freshly applied several times daily to remove entirely the smell of the decomposing parts. Of late, permanganate of potash (gr. x to § i water) has been greatly praised as a local antiseptic and disinfectant ; I have made several trials of it, but have found it far inferior to the remedies pre- viously mentioned. Concentrated solutions of carbolic acid in olive- oil (say 3 ij to lb 1) cause symptoms of poisoning (olive-green urine), hence they should be used carefully. As soon as the gangrenous mass has become somewhat detached, the shreds should be removed with the scissors, without cutting into the healthy parts ; this is par- ticularly important in gangrene of the subcutaneous cellular tissue, which is often extensive, as after infiltration of urine ; at the same time the local antiseptics should be continued till healthy granulations arise. Led by the anatomical conditions in spontaneous gangrene, it has been advised to break up the coagulation of blood, by stroking and rubbing the limb ; from the pain and swelling of the parts, this is rarely practicable ; in cases where I have had it done, it has had no effect on the progress of the gangrene. If the gangrene affect a limb, as in the various forms of sponta- neous and senile gangrene, I strongly urge you not to do any opera- tion till the line of demarcation is distinct. If there be merely gan- grene of single toes, leave their detachment to Nature ; if the whole foot or leg be affected, do the amputation so that it may be merely an aid to the normal process of detachment, i. e., on the borders of the healthy parts you try to dissect up only enough skin to cover the stump, and saw the bone as near as practicable to the line of demar- cation. Thus you will occasionally succeed in avoiding a new out- break of the gangrene, and in saving your patient's life. If the patient dies before a distinct line of demarcation has formed (as is frequently the case), you need not reproach yourself for having neglected am- putation, for you may rest assured that the patient would have died even sooner if amputation had been performed. The prognosis in gangrene from internal causes (as the older surgeons termed it) is generally bad. TREATMENT OF GANGRENE. 33^ The internal treatment should be strengthening, in some cases even stimulant. Nourishing food, quinine, acids, and occasionally a few doses of camphor, are proper. The severe pain in senile gan- grene often .calls for large doses of opium, or subcutaneous injection of morphine. For gangrene in stomatitis, after poisoning by mercury, we have no decided antidote ; the use of the mercurial should be at once stopped; if mercurial salve has been employed, the patient should be bathed, placed in a fresh, airy chamber, provided with clean body and bedclothes, and have a gargle with chlorate of potash or chlorine water. Nor have we any antidote for ergotin, which causes raphania ; emetics, quinine, and carbonate of ammonia are chiefly rec- ommended. We could only put off the continued absorption of putrid matter into the blood, by amputation ; but we have already mentioned that this is a very precarious remedy in spontaneous gangrene. 22 CHAPTER XIII. ACCIDENTAL TRAUMATIC AND INFLAMMATORY DISEASES, AND POISONED WOUNDS. LECTURE XXIV. I. Local Diseases which may accompany Wounds and other Points of Inflammation: 1. Progressive Purulent and Purulent Putrid Diffuse Inflammation of Cellular Tissue. — 2. Hospital Gangrene, Ulcerative Mucous-salivarv Diphtheria, Ulcerative Urinary Diphtheria. — 3. Traumatic Erysipelas. — L Lymphangitis. Gentlemen : When speaking of traumatic inflammation, I told you that it did not extend beyond the bounds of the injury, and that this was only apparently the case when we could not accurately ex- amine the injured part. I still maintain the truth of this. But we have already added that, from various accidents, either immediately after the injury, as in contused wounds, there may be very severe progressive inflammation, with putrefaction, or that, later, secondary inflammations may develop around the already granulating wound from causes which we mentioned at the time (Lecture XIII.). I must now tell you that still another series of peculiar, partly inflammatory, partly gangrenous processes occur in the wound, which cause severe, usually feverish, constitutional diseases. Some of the latter may also occur without any thing peculiar being observable in the wound. Lastly, substances may enter a wound already existing, or at the time of its occurrence (as from the bite of a poisonous or diseased animal), which may induce both severe local inflammation and gen- eral blood-poisoning. In this chapter I shall speak of all these things ; I will try to give you a general view of them. We shall speak first of the local symptoms which accidentally accompany a wound, or an inflammation due to other causes. HOSPITAL GANGRENE. 339 I. LOCAL DISEASES WHICH MAY ACCOMPANY WOUNDS AND OTHER POINTS OF INFLAMMATION. 1. For the sake of completeness, we here mention again progres- sive suppurative and sanio-purulent diffuse inflammation of the cellular tissue. Putrid matters which form on fresh wounds from gangrene of the surfaces of the wound, and may diffuse rapidly in the meshes of the cellular tissue, occasionally cause, on the second, third, or fourth day, those forms of inflammation of the cellular tissue that are char- acterized by rapid decomposition of the inflammatory product and by rapid extension. If the patient survives the demarkation of such a phlegmon, the process always ends with necrosis of the infiltrated cellular tissue and panniculus adiposus. The same thing occurs in fibrinous (diphtheritic) phlegmon. Both processes are usually ac- companied by severe constitutional symptoms. If suppuration has already begun, as long as the wound is open, phlegmonous inflam- mation may spread around the wound from mechanical irritation, foreign bodies, great congestion, retention and decomposition of pus in the recesses of the wound, or infection of the wound with phlogogenous substances of various sorts (Lecture XXL). 2. Hospital Gangrene, Gangroma JVbsocomialis; Pourriture des Hopitaux. — I will first describe the disease, then add a few remarks about the etiology. At a certain time we notice, especially in hos- pitals, that a number of wounds, as well those from recent operations as those that were granulating and cicatrizing, without known cause, become diseased in a peculiar manner. In some cases the granulat- ing surface changes partially or entirely to a yellow smeary pulp, which may be washed off from the surface, but more deeply it is firmly adherent. This metamorphosis extends not only to the granu- lating surface, but to the surrounding skin which was previously healthy, which becomes rosy-red ; this also assumes a smeary yel- lowish-gray color, and in from three to six days the surface of the original wound almost doubles. The increase in depth is less in the so-called palpous form of hospital gangrene. In other cases a fresh wound, or a granulating surface, rapidly assumes a crater shape, excretes a sero-putrid fluid, after the removal of which the tissues lie exposed. The surrounding skin is slightly reddened. The progress of this molecular disintegration to thin ichor is usually in sharply-cut circles, so that the wound may acquire a horseshoe or trefoil shape. This ulcerous form of hospital gangrene progresses more rapidly than the pulpous, and extends with especial rapidity in depth. Although both of the above forms occasionally occur separately, they are also seen in combination. I have seen the pulpous form oftener than the ulcerous, but acknowledge that my individual experi- ence of diphtheria of wounds is based on a small number of ob- 340 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. servations. Hospital gangrene does not attack chiefly large wounds, but rather insignificant injuries, such as leech-bites, cup-cuts, even the portions of skin denuded by a blister, while it never occurs on an uninjured part of the skin. The resemblance to diphtheritic inflam- mation of the mucous membranes is mentioned by some authors. But after seeing a wound infected from a diphtheritic mucous membrane, I am convinced that diphtheria and hospital gangrene are two differ- ent processes. A wound attacked by diphtheria is covered with thick fibrinous rinds ; the entire wound becomes infiltrated and the surrounding parts intensely erysipelatous ; then a large part of the infiltrated tissue becomes necrosed and breaks down or falls off in shreds. But we do not see the daily progress of pulpous degenera- tion, forming round figures on the margins of the wound, which are puffy, very sensitive, and inclined to bleed, as is so common in hos- pital gangrene. - It is well known that after diphtheria of mucous membranes paralysis is not unfrequent; but this has not been ob- served after hospital gangrene. In the latter disease there are at the same time constitutional symptoms : at first the fever is not gen- erally severe, but there is more or less gastric affection ; the tongue is coated, there is inclination to vomit, and general depression. The disease may prove dangerous to old or debilitated persons, es- pecially if it eats away small arteries and causes arterial haemorrhage. The large arteries often resist hospital gangrene wonderfully. I once saw a man, for whom an inguinal abscess had been opened, at- tacked by the pulpous form of the disease ; the skin of the groin to about the size of the hand was destroyed; the disease had ad- vanced so deep that about an inch and a half of the femoral artery lay exposed in the wound, and could be distinctly seen pulsating. I detailed a nurse to stay with the patient constantly, and to make instant compression if bleeding should occur, as it might at any mo- ment. The pulp was thrown off, the wound granulated rapidly, and after a long time complete recovery took place without haemorrhage. The erysipelatous redness accompanying diphtheritic phlegmon and hospital gangrene is occasionally as sharply bounded and desqua- mates as much as in erysipelas about wounds otherwise healthy ; but it has not the same tendency to spread. The constitutional septic poisoning is worse in diphtheria than in hospital gangrene. Views as to the causes of hospital gangrene vary ; this is chiefly because many living surgeons have had the good or bad fortune never to have seen the disease ; thus in Zurich it has never been seen. In his maxims on military surgery Stromeyer states, as a young physician in the Berlin Charite, he had only seen one case of hospital gangrene. Surgeons who have not seen this disease, or have only seen sporadic HOSPITAL GANGRENE. 341 cases, think it is due to gross neglect, dirty dressings, etc., and regard it as little more than an ulcer of the leg that has superficially become gangrenous from dirt and neglect. Other surgeons suppose that hos- pital gangrene is, as the name would indicate, a disease peculiar to some hospitals, and that its occurrence is only promoted by neglect of the dressings. Lastly, a third view is that this form of gangrene is due to epidemic influences, and that its name is in so far incorrect as it occurs outside and inside of hospitals at the same time. In the hospitals it probably spreads by inoculation, for I do not doubt that matter can be carried from gangrenous to healthy wounds by forceps, charpie, sponges, etc., and there excite the disease. Von Pitha and Fock have expressed the belief that it is an epidemic-miasmatic dis- ease. In the surgical clinic at Berlin with Fock I observed an epi- demic, while the disease was seen not only in other hospitals in Ber- lin, but in the city, in patients who could not be proved to have had any thing to do w T ith a hospital. The disease appeared very suddenly, and entirely disappeared in a few months, although the treatment of the wounds had not been at all changed, nor could any changes be made in the hospital itself. This seems to show that the causes do not lie in the hospital itself. Epidemic hospital gangrene might oc- cur from certain small organisms, which are rarely developed, which, like a ferment, induce decomposition in the wound and granulating tissue ; hence I should preferably compare this disease of wounds with blue suppuration, which causes no injury to the wounds, but, according to LiXcJce, like blue milk, is caused by small organisms and can infect other wounds. The requirements for the growth of these small bodies are probably particularly favored by certain atmospheric influences ; hence the disease spreads epidemically. There is no doubt that in the pulp of every hospital gangrene micrococci and streptococci are just as frequent as in the secretion of simple diph- theritic wounds. But it has not been proved that they were in the tissue before it was destroyed, that they grew in it, or broke it down into pulp ; nor has it been shown that this is a peculiar va- riety of micrococcus. But it is certain that the transfer of hospital gangrene pulp or putrid matter to healthy wounds usually (always, according to Fischer) induces hospital gangrene, and this is very important in practice. From my recent experience in the Vienna General Hospital, I am more and more convinced that this disease results from specific causes, entirely independent of pyaemia, septi- caemia, erysipelas, and lymphangitis, although it may be followed by either of these diseases. The first point in the treatment is strict isolation of the patients, who should have special nurses, dressings, and instruments. If this 342 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. does not entirely prevent the spread of the disease, as the contagion may possibly be carried by the air from a diseased to a healthy wound, still experience shows that it interferes with the spread. In some epidemics in military hospitals it was necessary entirely to va- cate certain localities. Locally we should apply strong chlorine- water, or spirits of camphor or turpentine, to these wounds. Some- times painting the part every two hours with tincture of iodine acts well, or solution of acetate of alumina applied on a compress till the wound becomes clean; but the solution should not be too concen- trated, and its application should be stopped when the process ceases to spread. If this also prove ineffectual, it has been recommended to burn the wound down to the healthy tissue, so that the slough shall remain attached six or eight days, as in a healthy wound. I find it just as effectual to cauterize the wound with fuming nitric acid or carbolic acid, but these cauterizations also should extend to the healthy borders of the wound, and be repeated till the slough remains adherent. The general treatment should be strengthening, or even stimulant. The fever occurring in hospital gangrene is due to reabsorption of putrid matter, and does not differ from other forms of putrid fever. The pulpous phagedenic gangrene above described is especially apt to occur in wounds of the mouth or urinary bladder, even with- out any external source of infection. I mention this here because these diseases are doubtless allied to phagedenic diphtheria, al- though, from their limitation to certain parts of the body, they more properly belong to special surgery and the clinic. After extirpation of large portions of the tongue and resection of the lower jaw, I have sometimes seen a rapid pulpy breaking down of the wound fol- lowing hard and extensive infiltration of the cellular tissue ; here there is a combination of diphtheritic phlegmon with phagedenic ulceration. Most of these cases ended fatally from septicaemia ; others recovered after the whole cellular tissue had become necrosed and been thrown off by free suppuration. Although mucus and saliva coming in contact with these wounds may have no phlogoge- nous or septic qualities of their own, putrid ferments may be mixed with them, such as are occasionally found in the coating on the gums and between the teeth of patients who do not clean their mouths ha- bitually, or neglect this on account of painful ulcers in the mouth. So this ferment will be carried to wounds in the mouth by the mu- cus and saliva, thus justifying the name mucous salivary diphtheria. This disease only threatens the patient during the first five days after operation ; only recent wounds in the mouth are infected by the ferment in question ; if good granulations have once developed, HOSPITAL GANGKENE. 343 this diphtheria does not occur, unless there be infection from with- out, or the wound be mechanically injured and the granulations partly destroyed. In this disease the constitutional symptoms may be very severe, and the patients are particularly subject to sudden collapse, which is the more dangerous as, from the impairment of nutrition which has often gone before, the patients are usually much debilitated. After operations for stone, urethrotomy, vesico-vaginal fistula, or ectopia vesicae, pulpous breaking down of the edges of the wound, with fibrinous coating of the walls of the bladder or of the vagina, is not rare, especially when the urine is alkaline. As this disease is associated with decomposition of the urine, it is called urinary diph- theria. This form of diphtheria is the mildest of those above men- tioned, from having little tendency to spread, and running its course without constitutional symptoms, if the wound is kept clean. Rarely the mucous membranes break down, but more frequently the process becomes a purulent retroperitonitis, which becomes a peritonitis and causes death. Diphtheritic inflammation of the vagina also may spread as superficial suppuration to the inner surface of the uterus, and thence through the oviducts to the peritoneum ; this suppurative peritonitis also is usually fatal. Under such circum- stances I have never seen fibrinous inflammations. In the latter cases, which unfortunately are not rare after confinement, but do not often occur after operations for vesico-vaginal fistula, severe consti- tutional symptoms are early manifested. In the pulp from mucous-salivary and from urinary diphtheria micrococci and streptococci are constantly found ; they are just as regularly found in the coating of the gums and tongue, and in urine which has become alkaline, but seem to develop with particular ra- pidity in this pulp. The contagious principle of this pulp has not yet been separated from the micrococcus ; so we may suppose the latter has in or on it the contagious material. There is no proof that micrococci from any source can excite this process ; but many observations tend to show that these vegetations take up contagious substances very readily, and so become vehicles of contagions and ferments. If we inoculate the cornea of a rabbit with a fluid con- taining micrococci, the interesting experiments of JVassiloff, JEberth, Leber, Stromeyer, Dolscherikow, Orth, Frisch, and others show that the coccus grows to a certain point, and in some cases (when unac- companied by any peculiarly injurious substances) causes irritation, chiefly mechanically, by separating the corneal lamellae, so that the coccus colony gradually becomes enveloped in pus, and then is thrown off with the pus ; but in other cases (if the inoculated mat- 344 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. ter has very deleterious properties) the whole cornea may become gangrenous in twenty-four hours, and the growth of the coccus hardly be as great as in the first instance. Lastly, cases occur where the coccus growth induces no reaction in the cornea, but disappears without leaving a trace; this is even the rule in inoculating the cornea of the dog. Fig. 66 a. a, Fungus from the cornea of a rabbit ; coccus proliferation between the lamellae of the cornea, in- duced by inoculation ; slightly magnified, b, One point of a, magnified 600. After Frisch. From this it follows that the intensity and nature of inflamma- tions induced by such contagions do not depend on the coccus pro- liferation itself, but on the injurious qualities of the matter conveyed with the coccus. I thought you should be told these things, so that you would have some knowledge about processes which are now so much dis- cussed. I recommend for your special study the excellent mono- graph on hospital gangrene by C. Heine. 3. Erysipelas traumaticum. Erysipelas, as previously mentioned (page 281), is classed among the acute exanthemata, and is charac- terized by a diffuse swelling, rosy redness of the skin, and pain, as well as by the accompanying fever, which is usually severe. Erysip- elas has a peculiar relation to the other exanthemata ; on the one hand, because it often accompanies wounds, although it may appar- ently come spontaneously ; on the other hand, because it does not generally spread by such an intense contagion as measles, scarlatina, etc. ; lastly, also because, when one has had this disease, he is not only not safe from another attack of it, but in some cases is even pecu- liarly predisposed to it. As I dare hardly assume that you have al- ready studied skin-diseases carefully, we will here briefly review the symptoms of this disease. Its commencement may vary by the fever preceding the exanthema, ERYSIPELAS TRAUMATICUM. 345 or by their simultaneous appearance. Suppose you have a patient with a suppurating wound of the head, and after he has been previ- ously well, and the wound was healing nicely, you find him with high fever, which may have been preceded by a chill ; you examine the pa- tient, and can find nothing but some gastric derangement, as evinced by a coated tongue, bad taste in the mouth, nausea, and loss of appe- tite. This state is present at the onset of so many acute diseases that you cannot at once make a diagnosis. Besides the possibility of an accidental complication with any acute internal disease, you would think of phlegmon, lymphangitis, and erysipelas. Perhaps twenty-four hours later you find the wound dry, discharging a little serous secre- tion ; for some distance around there are swelling, redness, and pain, or the granulations are large, swollen, and croupous ; the redness of the skin is of a rosy hue and everywhere sharply bounded y the fever is still tolerably intense ; now the diagnosis of erysipelas cannot be mis- taken, and we are well content that we have to deal with a disease which, although not free from danger, is one of the less dangerous of the traumatic diseases. In a second series of cases the erysipelas ap- pears with the fever. We may for a brief period doubt whether the case be one of lymphangitis, inflammation of the subcutaneous cellular tissue, or of erysipelas, but the course of the disease will soon show this ; the extent that the erysipelatous inflammation of the skin has the first day rarely remains the same, but it usually spreads farther and farther, in such a way that the rounded, tongue-shaped, project- ing borders of the inflamed skin are always sharply bounded, and we can accurately follow its removal from one side to the other ; in many cases the redness advances like fluid in bibulous paper. Thus the process may extend from the head to the neck, thence to the shoul- ders, or the anterior part of the trunk, or even pass down the arm, and finally may even reach the lower extremities. Pfleger has observed that the mode of extension of wandering erysipelas is almost always the same, and is probably due to the flow of certain fluids (lymph), which again depends on the arrangement of the filaments of the cutis. As long as the erysipelas spreads in this way, the fever usually remains at the same height, and thus old or debilitated persons are readily exhausted. Most cases last from two to ten days ; it is rare for one to continue over a fortnight ; the most protracted case I have seen was one lasting thirty-two days and recovering. In this erysipelas ambulans or serpens you will notice that the same grade of inflammation of the skin only continues a certain length of time in one place, so that when the erysipelas advances, the whole surface is not inflamed at once, but only a part at a time is at the acme of the local inflammation. After the inflammation has remained at the same point about 346 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. three days, the redness grows less, the skin desquamates, partly as a bran-like powder, or in scales and tags of epidermis. In some cases, even at the commencement of the erysipelas, the epidermis rises in vesicles, which are filled with serum {erysipelas bullosuni). But this erysipelas is not a peculiar form of the disease ; it only indicates rapid exudation. We not unfrequently see vesicles appear on the face in erysipelas, while on the rest of the body the disease has the usual form. If erysipelas attacks the scalp, the hair often falls, but grows again quickly. According to my experience, the disease is most fre- quent on the lower limbs, then on the face, upper extremities, breast and back, head, neck, and belly. This scale of frequency probably depends on the proportionate numbers of injuries in the different parts of the body. Erysipelas, like other exanthemata, may be accompanied by vari- ous internal diseases, as pleurisy, and erysipelas capitis by meningitis ; but, on the whole, these complications are rare, and when they occur are usually a result of the disease advancing to the deeper parts. The course of erysipelas is usually favorable. Of one hundred and thirty-seven cases of the uncomplicated disease, which I observed in Zurich, ten died ; children, old persons, and patients debilitated by previous disease are most endangered, and, according to my experi- ence, they usually die of exhaustion from the continued fever ; on autopsy, we find no remarkable change of any organ that can be re- garded as the cause of death. Cloudy swelling and partial granular degeneration of the liver, kidneys, and epithelium, and softness of the spleen, are found in cases of fatal erysipelas, as after all intense blood- diseases. The nature of erysipelas is not fully understood, as its cause and the mode of its progress are not quite clear. Dilatation of the capillaries of the cutis, serous exudation in the tissue itself, and an active development of the cells of the rete Malpighii are all we can find anatomically. The disease rarely extends to the subcutaneous cellular tissue ; it is true, this swells enormously in some places, as in the eyelids and scrotum, being greatly saturated with serum ; but in most cases this oedema recedes without any sequelae. In rare cases this oedema attains such a grade that, as a result of the great distention of tissue, the circulation of blood is arrested, and the parts (as the eye- lids) may become wholly or partly gangrenous. Should all the skin of an upper or lower eyelid be lost in this way, it would cause great deformity ; but usually only small portions mortify, and, in the upper lid particularly, the skin is so plenty in most persons that the defect is subsequently but little noticed. In other cases, after the subsi- dence of the erysipelatous inflammation, there remains a swelling of the subcutaneous tissue, in which we may distinctly feel fluctuation, ERYSIPELAS TRAUMATICUM. 347 and by incision may evacuate pus. Microscopic examination of skin, affected with erysipelas shows only more or less infiltration of the cutis and subcutaneous tissue. The causes of erysipelas evidently vary ; that occurring without a wound, spontaneous erysipelas capitis, is said to come most frequently after catching cold. Some old persons are said to have this disease every year, in spring or autumn ; psychical influences are also blamed for it, especially terror, particularly in women during their menses. I cannot vouch for the latter, but think it may belong to medical traditions. Disturbances of digestion are also regarded as causes. I am very skeptical of all the views which are not based on accurate observation, but rest on tradition; indeed, I consider it doubtful whether erysipelas ever occurs without having started from a wound or some point of inflammation already existing. From what I have seen of erysipelas traumaticum, my idea con- cerning it is as follows : I consider the local affection as an inflamma- tion of the cutis, in which the inflammatory irritation gradually spreads through the lymphatic net-works ; the way in which the in- flammatory redness spreads and is sharply bounded shows positively that the process is limited to the vascular districts ; by close observa- tion we may see that very often, close to the border of the redness, there forms a red, round spot, at first circumscribed, which soon unites with the previously-reddened portions of skin ; these newly- forming red spots evidently represent vascular districts ; we see something similar when we inject the skin through an artery ; then, too, the color from the injection first appears in spots, and only unites when heavy pressure is made on the syringe ; now, as the venous and lymphatic districts in the skin are to some extent analogous to the arterial, the irritating poison causing the dilatation of the blood- vessels might circulate in one of these tracts. The arterial and venous tracts in the cutis have few connecting branches parallel to the surface, while the lymphatic vessels have very many, and but few branches going down into the subcutaneous tissue ; thus the exciting poison may readily spread superficially in the cutis, like liquid in bibu- lous paper, but it also enters the subcutaneous lymphatics, and often causes inflammation there, as well as in the neighboring lymphatic glands, striated redness of the skin, and swelling of the adjacent lymphatic glands. When I here speak of a septic or other similar poison as a cause of erysipelas, I refer only to traumatic erysipelas, for I think I have satisfied myself by observation that this is always of toxic origin. Concerning the nature of this poison, I may say : 1. It is chiefly blood mixed with decomposing secretion from the wound that induces erysipelas, which then appears the second or 348 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. third day after the injury or operation. 2. There is probably a dry, dust-like substance, which, coming on the wounds, whether fresh or granulating, causes erysipelas ; this substance clings especially to sponges and dressings. I have often observed that patients operated on after each other, under the same circumstances, in the same operating-room, all had erysipelas on the fresh wounds a few hours after the operation, without retention of secretion from the wound, although they lay in perfectly separate wards of the hospital. Ery- sipelas thus becomes domesticated in the hospital ; the infecting sub- stance may be transported on the clothes of the surgeons making the dressings ; it may adhere to instruments, beds, or even to the walls. The more accurately I examined the cases of erysipelas in the Zurich hospital, and in my clinic in Vienna, the more evident was its occur- rence in groups — an occurrence entirely independent of all other morbid influences outside of the hospital. From statistics during two years, supported by contributions from the physicians of the Canton Zurich, I have found that during that time erysipelas had not occurred epidemically in the country or city, but that, like other acute diseases, it was particularly frequent in autumn and spring ; hence erysipelas epidemics in hospital must depend on circumstances that are to be sought in the hospital itself, and which I have already indicated. Here arises the question whether the poison which excites erysipelas is always the same, whether it is specific. This cannot be accurately answered : in its favor is the fact that the form of the cu- taneous inflammation induced is always the same, although varying in intensity and extent ; against it we may say that erysipelas is probably caused by various kinds of putrefaction, by miasma, per- haps also by some animal poisons. Possibly in all of these poison- ous substances there might be one certain material which induced erysipelas, particularly a variety of material, which had a specific affin- ity for the lymphatic vessels of the skin ; it must be acknowledged that, under certain circumstances, existing at some particular time, such a material may develop more readily and extensively than at other times. It has often been asserted, and of late more particu- larly by Orth, that erysipelas extends by micrococcus vegetation from the wound to the skin. Although the spread and reproduction of the erysipelas contagion much resemble those of a ferment, there is as yet no proof that in erysipelas the micrococcus is the bearer of such a ferment, still less that it is only micrococcus. I do not up- hold the correctness of this view. I have sometimes found coccus and streptococcus in the serum of erysipelas vesicles, but they are also found in blisters from burns or sweating, in small-pox pustules, etc. ; and this is no proof that these diseases are due to micrococ- ERYSIPELAS TRAUMATICUM. 349 cus. It is doubtful whether the suppurations induced in rabbits by inoculation with the serum from erysipelas blisters is identical with the erysipelas of man. The most recent work on erysipelas, by LulwmsJcy, shows the near relation of micrococcus to erysipelas ; T can confirm his observations from others made at my clinic by JEhrlich ; but interesting as these are, they cannot settle the vexed question as to the etiology of erysipelas. The disease always begins with a rapidly-increasing fever, which continues as long as the eruption lasts ; it may be either remittent or continued, sometimes terminates with critical symptoms, sometimes gradually. I have no extensive experience of the so-called idiopathic erysipelas capitis et faciei ; from what I have seen, it seems to me very probable that this also starts from slight wounds (excoriations on the head or face) or inflammations (nasal catarrh, angina), and is also chiefly of toxic origin. The treatment of erysipelas is chiefly expectant. We may try prophylaxis by carefully cleansing the wound, and thus keeping off every thing that can favor the occurrence of erysipelas ; and when several cases occur in hospital, we should carefully guard against too many of them being in one ward, and occasionally some of the wards should be entirely vacated and ventilated for a time, to prevent the development of a more intense erysipelas contagion (little as w T e cer- tainly know of it). As to the local treatment, a series of remedies has been tried to prevent the advance of the erysipelatous inflammation and arrest the disease at its commencement. For this purpose we circumscribe the borders with a stick of moist nitrate of silver or with strong tincture of iodine. According to my experience, this does little good, so that of late I have entirely left off this treatment. Older physicians thought that cold might force the cutaneous inflammation back, and thus greatly favor inflammation of the internal organs. Although this cannot be regarded as proved, a series of facts renders the use of cold apparently unadvisable. We have already mentioned that the occasionally great oedema may induce gangrene, which of course would be greatly favored by intense cold ; and the application of bladders of ice to a large surface, as to the back or the whole face, is scarcely practicable ; lastly, the ice does no good, as in spite of it the dis- ease runs its typical course, for here almost more than in any other inflammation the local process and general infection go hand in hand. In the affected skin the patient has a disagreeable tension, a slight burning, as well as great sensitiveness to draughts or other changes of temperature. Hence it is advisable to cover the diseased skin and protect it from the air. This may be done in various ways : 350 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. the simplest, which I usually employ, is to smear the surface with oil and apply wadding ; the patients are generally satisfied with this. Others sprinkle the inflamed skin with flour or powder, or scatter finely-rubbed camphor in the wadding that is to be applied, thinking thus to act specially on the local process. If vesicles form, they should be opened with fine needle-punctures, and the loosened epidermis be left to dry. If gangrene develop anywhere, moist warmth in the form of fomentations or poultices should be applied till the eschar has detached and healthy suppuration begun, which is then favored by dressings of charpie dipped in chlorine-water. If, after erysipelas, abscesses form in the subcutaneous tissue, they should be opened early and treated like any suppurating wound. Among the internal remedies, we have one which may perhaps arrest the development of some cases of the disease. If in strong, otherwise healthy persons, in whom the gastric symptoms are very prominent, we give an emetic, the advance of the erysipelas is often checked. This is not absolutely reliable, but you may try it in suit- able cases. Subsequently you employ only the ordinary cooling reme- dies. If symptoms of debility show themselves and the disease drag on, you should begin with tonics and stimulants ; you may daily give a few grains of camphor or quinine, or some wine. The inflammations of internal organs occasionally complicating erysipelas are to be treated lege artis, and in meningitis you must not be afraid to keep a bladder of ice constantly on the head, even if the scalp is affected by the erysipelatous inflammation. 4. Inflammation of the lymphatic vessels {lymphangitis), actual inflammation of the lymphatic vessels, occasionally occurs in the ex- tremities under various circumstances, which will be mentioned im- mediately. The symptoms, in the arm for instance, are as follows : There is a wound of the hand ; the whole arm becomes painful, espe- cially on motion ; the axillary glands swell and are sensitive, even on the slightest touch. If we inspect the arm carefully, we find red striae, especially on the flexor side, running longitudinally from the wound toward the glands ; these reddened portions of skin are very sensi- tive. At the same time there is fever, often a coated tougue, nausea, loss of appetite, and general depression. The termination may be in one of two directions : under proper care and treatment, there is gen- erally resolution of the inflammation ; the striae gradually disappear, as do also the swelling and pain of the axillary glands ; the fever ceases at the same time. In other cases there is suppuration ; the skin of the arm reddens gradually and extensively in a few days and becomes cedematous. The swelling of the axillary glands increases, the fever becomes greater, and there may even be chills. In a few ERYSIPELAS TRAUMATICUM. 35 j days fluctuation occurs, most frequently in the axilla, occasionally else- where in the arm, the abscess opens spontaneously or is incised, and pus, such as is usually contained in a circumscribed abscess, is evacu- ated. Then the fever subsides, as do also the pain and swelling; and the patient speedily recovers from his disease, which is often very painful and troublesome. The termination is not always so favorable ; but, in lymphangitis from poisoned wounds, pyaemia is occasionally developed, in the subacute form most frequently; of this more here- after. In one case with lymphangitis of the leg, where the patient had chronic inflammation of the kidneys at the same time, I saw the in- guinal glands with the superjacent skin become gangrenous, after they had been enormously swollen. This termination is very rare, although the pus in these inflammations of the lymphatic vessels, especially after poisoning with cadaveric matter, is occasionally putrid in char- acter. Acute inflammation of the lymphatic glands ; terminating in resolution or suppuration, occurs as an idiopathic disease ; in such cases we cannot see the connection, by red lines along the lymphatics, between a wound, or another point of inflammation, and the lymphat- ic glands ; this may be because only the superficial vessels appear as red cords in the skin, while the deeper ones, even when inflamed, are not recognizable to the sight or touch. Hence in the patient we only know superficial lymphangitis. One of the peculiarities of this dis- ease is, that when it occurs in the extremities it rarely extends be- yond the axillary or inguinal glands. Once in a case of lymphangitis of the arm and adenitis of the axilla I saw pleurisy occur on the same side, which possibly may have resulted from extension of the in- flammation through the lymphatic vessels. We know very little of the pathological anatomy of lymphangitis of the subcutaneous tissue, scarcely more than we can see with the naked eye on the patient, for this disease is scarcely ever fatal when it only attacks the lymphatic vessels, and in animals it can only be very imperfectly induced by experiment. The cellular tissue imme- diately around the lymphatic vessels is decidedly implicated, the capillaries dilated and distended with blood. We cannot decide whether the lymphatic vessel is obstructed in the later stages by coagulating lymph, or whether coagula form in the lymph at the start and irritate the walls of the vessels. If we may transfer the obser- vations on uterine lymphangitis, which so often occurs in puerperal fever, to the skin, in certain stages there is pure pus in the dilated lymphatic vessels; the vicinity of these vessels is infiltrated with serum and plastic matter; the plastic infiltration of the cellular tissue increases to suppurative infiltration, or even to formation of abscess, in which the thin-walled lymphatic vessels themselves disappear ; the 352 TKAUMATIC AND INFLAMMATORY DISEASES, ETC. finer the net-work of lymphatic vessels, the more difficult it is to dis- tinguish lymphangitis from inflammation of the cellular tissue. From the illustrations of Cruveilhier (Atlas, Livre 13, PI. 2 and 3), we may derive an idea of puerperal lymphangitis, and carry this to the same affections in other parts. The red stria? that we see in the skin can only be caused by dilatation of the blood-vessels around the lymphatics, not by blood forcing its way into the latter ; hence in patients we really see the symptoms of perilymphangitis induced by contact with the poison streaming in the lymphatic vessels. We know the changes in the lymphatic glands rather better. In them the vessels are much distended, and the whole tissue greatly infiltrated with serum ; quantities of cells fill the alveoli tensely, which probably at first im- pedes and finally arrests altogether the movement of the lymph in the gland ; this blocking up of the gland will to some extent prevent the extension of the morbid process. Lymphangitis may occur in any wound or point of inflamma- tion ; but in my opinion it is always the result of imitation from a poison passing through the lymphatic vessels. The nature of this poison may vary; it may be decomposed secretion from a wound, putrid matters of all sorts (especially that from the cadaver), or matters which from excessive irritation form an inflamed point. We have already stated that the friction from a boot-nail may excite a simple excoriation into a diffuse inflammation, in which a (phlogistic) poison may and often does form, and excites lymphangitis ; the same thing occurs in points of inflammation from other causes ; by increased irritation a material is formed in the inflammatory focus itself, which proves very irritant to the lymphatic vessels and their surroundings ; even a poison encapsulated in an inflamed part may by increased pressure of the blood be driven into the lymphatic vessels, and thence into the blood, although without this cause it might have remained quiet, and been gradually thrown off or eliminated by sup- puration. The following case may serve as an illustration : One of my colleagues had a slight inflammation on the finger, from a dis- secting wound ; this inflammation was purely local, scarcely observ- able ; on a short trip in the Alps he became heated, in the evening he had a lymphangitis of the arm and high fever ; the active move- ment and consequently increased action of the heart had driven the poison, previously lying quiet in the circumscribed point of inflamma- tion, through the lymphatic vessels into the blood. Why, in the different cases, we have sometimes diffuse phlegmonous inflammation, sometimes erysipelas or lymphangitis, cannot be certainly stated, though it may be due to purely local causes, and to the character of the poison. From our present knowledge of the passage of cells PHLEBITIS. 353 out of the vessels we may imagine that pus-cells developed in the wound thence pass into the lymphatic vessels, wander through the walls of these vessels, and as bearers of an irritating substance excite perilymphangitis, wmile the cells, flowing more rapidly in the centre of the vessel, enter the blood, and thus perhaps induce fever before the local disease has attained any considerable extent. The object of treatment in recent cases of lymphangitis is to ob- tain resolution if possible, and to prevent suppuration. The patient should keep the affected limb as quiet as possible ; should there be gastric derangement, an emetic is very beneficial. The disease not unfrequently subsides after the purgation and sweating induced by the emetic. Among the local remedies, rubbing the whole limb with mercurial ointment is particularly efficacious ; then the arm should be covered warmly so as to maintain an elevated, regular tempera- ture. For this purpose w T e may employ wadding or moist warmth. Should the inflammation increase in spite of this treatment, and dif- fuse redness and swelling occur, suppuration will take place at some spot. This diffuse inflammation is no longer limited to the lymphatic vessels, but the entire subcutaneous tissue participates in it more or less. As soon as fluctuation is distinctly perceived, an opening should be made, and the pus evacuated. Should healing be retarded, it may be hastened by daily warm baths ; these are particularly use- ful where there is a great tendency for the disease to return to a spot once attacked. A septic poison encapsulated in the lymphatic glands, if forced into the circulation by fluxion to the glands, may in- duce new lymphangitis and phlegmonous periadenitis ; this explains the repeated relapses, and the latency of the disease after infection, especially in dissecting wounds. LECTURE XXV. 5. Phlebitis ; Thrombosis ; Embolism. — Causes of Venous Thrombosis ; Various Meta- morphoses of the Thrombus. — Embolism. — Eed Infarction, Embolic Metastatic 4bscesses. — Treatment. o. Phlebitis ; T/irombosis ; Embolism ; Embolic Metastatic Ab- scesses. — Besides the above forms of inflammation, there is often another phlebitis and thrombosis, which, starting from a wound or point of inflammation, is at first local, but afterward spreads in a pe- culiar manner to several organs. In persons dying from this disease we find pus, or friable, purulent, or putrid clots, in the thickened or partly-suppurating veins near the injured part. Often, also, there 23 354 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. are abscesses in the lungs, more rarely in the liver, spleen, and kidneys. Cruveilhier proved that these metastatic abscesses were connected with the pus in the veins ; but the mode of this connection was not explained till subsequently. What I shall tell you to-day on this subject is the result of numer- ous investigations and experiments, for which we are indebted to Virchow, and which have been so often repeated and confirmed by different persons that there can be no doubt of their correctness ; I have myself studied the subject a good deal, and shall at the proper places state where I have arrived at different results. It would lead me too far to follow this great work of Virchow historically, and to give you an epitome of it ; I must leave it to your own industry to study these works, and content myself with giving you a short resume of the positive results. The first important question is, What is the relation of the co- agulation of the blood to the inflammation of the vessel ? The former view, that the coagulation is due to the inflammation of the wall of the vessel, is purely hypothetical, and not susceptible of proof. On the contrary, we know from the investigations as to the formation of thrombus after ligation of arteries, and of the process of healing of injured veins, that there is immediate coagulation of blood in the injured vessel, before there can be any inflammation of the walls of the vessel. The blood-clot forming in veins after their injury, and constituting their thrombus, is usually short, it is true, but we may readily imagine that it should increase in size from continued de- posits of fibrine. You know, from your studies in physiology, that we cause coagulation of the fibrine by whipping the blood. During the motion of the blood the coagulating fibrine deposits like crystals on a rough body, and you can readily satisfy yourselves experiment- ally that such a body, as a cotton-thread, introduced into the vein of a living animal, soon becomes covered with fibrine. Thus rough- nesses of various kinds in the vessels may give rise to more or less extensive coagulations of the blood. These roughnesses may cer- tainly form on the inner wall of the vein as a result of inflammation, and coagulation of the blood may thus be induced. Projections into the calibre of the veins may be caused by small abscesses in the walls ; formerly, it was supposed that there was a fibrinous coagula- tion on the inner surface of the inflamed vein, as on an inflamed pleura ; it can scarcely be decided whether this really occurs ; what was formerly considered as such has been found to be a discolored pe- ripheral layer of the blood- clot. At all events, inflammation of the walls of the vessel very rarely causes the coagulation ; much more fre- quently the clot forming in a vessel after injury, under certain not accu- THROMBOSIS. 355 rately-known circumstances, forms the starting-point for further coagu- lation, and finally for inflammation of the wall of the vessel. Besides injuries, there is a second factor from which coagulations may result, viz., from retardation of the current of the blood from friction, as in contraction of the vessel ; this variety may be called thrombus from compression. It also is independent of inflammation of the wall of the vein, but may result from inflammation of the perivenous tissue ; for in severe inflammation a tissue, especially when it is under the pressure of a fascia, may swell so much, partly from serous, partly from plastic infiltration, that the vessels will be compressed, and stasis and coagulation of the blood be thus induced. These thrombi, from compression in very acute inflammation, and especially in acute acci- dental inflammation of cellular tissue around wounds, are more frequent than primary traumatic thrombi ; it is the most dangerous variety of thrombus, as it is most liable to puriform deliquescence. 18 In rapid dilatation of a vessel, also, according to physical laws, the current of blood is much retarded ; then coagulation takes place at the point of dilatation, as we shall hereafter see in aneurisms and varices ; these are called thrombi from dilatation. Furthermore, the current of blood may be retarded from insufficient contraction of the heart and arte- ries ; as this occurs chiefly in persons debilitated by age or severe ex- hausting diseases, it is called marasmic thrombus. This, also, is evi- dently independent of inflammation of the veins, and occurs most fre- quently in parts distant from the heart. You must remember that in all these cases the thrombi are at first small, and gradually grow from deposit of more fibrine. It has not been proved that, in cases where the thrombus attains a considerable extent, there is any abnormal increase of fibrine in the blood, although this might be supposed. Why traumatic thrombi should extend so far in some cases of injuries of the veins, we can only understand in cases where extensive ruptures of the veins are caused by extensive contusions, and extensive disturbance of the circulation is thus induced. But, in cases where a widely-branched thrombus results from a punc- tured or incised wound of a vein (as from venesection), it is often difficult to explain the cause without resorting to disputed hypotheses. Thrombi from injury and compression, and their sequelas, particularly claim our attention, while those from dilatation and marasmus we rarely meet in surgical cases. It has been observed that venous thrombi ending in suppuration are far more frequent in hospitals than in private practice, and this tendency to coagulation of the blood has been referred to the hospital atmosphere and the miasma it contains. That hospital miasm (itself a very indefinite and very variable thing) should directly induce coagulation of the blood, can neither be proved 356 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. nor denied. According to my idea, the connection is probably only indirect : toxic-miasmatic infection of a wound, whether induced by instruments, dressings, or otherwise, as previously stated, excites acute suppurative inflammations around the wound, sometimes as ordinary cellular inflammation, sometimes as diifuse lymphangitis, etc. ; thrombi from compression are caused by these inflammations, just as happens in acute phlegmonous inflammation outside of the hospital ; hence the influence of miasmatic poisoning in inducing venous thrombosis is not direct, but indirect, acting through the inflammation. The next question is, What becomes of the blood coagulated in the vessels, and what is its relation to the wall of the vessel ? From the injuries of arteries and veins, we are only acquainted with one meta- morphosis of the thrombus, namely, its organization to connective tissue. In extensive venous thrombi this is a great rarity, and leads of course to complete obliteration of the vein. Let us take a very simple case, a venesection thrombus. After a bleeding, say from the median vein, from an acute inflammation of the cellular tissue there is a coagulation of blood in this vein, and also in the cephalic and basilic veins, down to the wrist and up to the axilla. From the disturbance of the circulation thus caused, there is great oedema of the whole arm ; when this subsides, we may distinctly feel the subcutaneous veins as hard cords. The course may vary : first, the affection may possibly end in resolution — under timely treatment this is usual ; the patient should be kept in bed, as he is usually feverish ; the arm should be kept absolutely quiet, and covered with a compress thickly coated with mercurial ointment. At the same time we give a purgative, and, if the tongue be coated, an emetic. Under this treatment, the swell- ing of the arm usually decreases, and the fever subsides. Then the firm venous cords can be plainly felt ; in six or eight days they become softer, and finally cease to be perceptible. We very rarely have the chance to examine such cases anatomically in the early stages. Hence, we cannot decide to what extent, if at all, the walls of the vein parti- cipate in this coagulation of the blood ; but, from the symptoms and the examination of the patient, it would appear that the fibrine coagu- lated in the vessels is gradually reabsorbed and mingles with the blood without injury, like other blood that has been diffusely extra va- sated in the tissue. The second termination of inflammation of the arm after venesection, complicating thrombosis, is the formation of abscess. The first symptoms are those above described ; but then, either in the bend of the elbow, the arm, or the forearm, a more circumscribed inflammatory tumor forms ; this increases gradually, and finally fluctuates distinctly. On incision, pus is evacuated from a larger or smaller cavity, the swelling of the arm then gradually de- THROMBOSIS. 357 creases, the abscess heals, and complete cure may result. Anatomical examination of these cases shows that there has been suppurative inflammation in the connective tissue around the vein. We also find that the coats of the thrombosed veins are greatly thickened ; this is to be regarded as a result, not as a cause of the thrombosis. I will here add that the diagnosis of a venous thrombus cannot always be made, from the vein feeling like a hard cord ; for occasionally inflam- mation in the cellular tissue around the vein may extend, and cause condensation and tube-like thickening of the sheath of the vessel, which may readily cause it to be mistaken for thrombus, though it does not necessarily lead to it. I have twice seen this mistake of periphlebitic cellular induration for thrombus of the saphenous vein, and I consider it impossible to make a certain diagnosis in all cases. The fact that such a periphlebitis, which is perfectly analogous to perilymphangitis, and in which the walls of the veins certainly parti- cipate, can exist without thrombosis, proves beyond a doubt that the latter is not necessarily the cause of inflammation of the veins, as was formerly supposed. Another possible metamorphosis of thrombus is friable disintegration. In this, softening of the clot usually begins at the point where the thrombus began, that is, at the oldest part. The fibrine breaks down into a pulp, which is yellowish or brownish, and smeary in proportion to the number of red blood-corpuscles contained in the coagulum. This disintegration spreads more and more ; even the tunica intima of the vein does not escape, it becomes wrinkled and thickened. The thrombus changes to pus, which mingles with the detritus of the fibrine, while the walls of the veins and surrounding cellular tissue are greatly thickened; occasionally, although rarely, small abscesses form in the walls of the vein. Hence, here the inflam mation of the wall of the vein is to be regarded as the result of soft- ening of the thrombus, and the pus which we then find in the vein does not come from the wound (the old idea), but forms in the vein from the blood-clot. Often, also, the puriform fluid is only fluid fibrinous detritus, while in many cases good thick pus, with fully-de- veloped corpuscles, may be found in these veins. If the wound be putrid, the fibrinous detritus in the vein may also assume a putrid character, putrid fluid being taken up by capillary action of the throm- bus from the wound and acting as a ferment on the disintegrated fibrine. This capillary action of the thrombus might also be supposed to cause an action of the decomposed secretion on the blood. Of course there can be no extensive flow of pus or other secretion from the wound into the vein, as the opening in the vessel is plugged by the thrombus. Should there be a rapid disintegration of the venous throm- bus from the peripheral to the central ends, which is rare, there would 358 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. at once be venous haemorrhage, and the formation of a new thrombus, so that even then there could be no entrance of the pus from the wound into the vein, or of that from the vein into the blood ; moreover, the pus forming and collected in the vein is so shut off by the central end of the thrombus, that it cannot mingle with the blood ; at least this could only happen if the central end of the thrombus should be entirely broken down, but this probably happens very exceptionally, for in most cases there are constantly new deposits of fibrine, while disinte- gration goes on from the oldest parts of the thrombus. You will thus understand that the entrance of pus into the injured vein cannot read- ily occur, but that, as will be soon stated, the circumstances must be very peculiar to render this possible. I must here briefly interrupt the description, to state that Virchow does not distinctly acknowledge the transformation of the thrombus to pus ; I have no doubt on this point : if the blood-cells in the thrombus have the power of increasing and changing to tissue, as seems most probable, there is no reason for not referring to them the formation of pus in the thrombus, just as we do to the white cells wandering out of the vessels, for the coagu- lation of the blood is not firm enough to entirely prevent cell-move- ment. That the thrombus may change to true pus by division of the white blood-cells does not appear to me disproved ; we have already mentioned that this pus, which is usually encapsulated, does not enter the circulation, or does so very rarely, and hence has no direct con- nection with pyaemia. To resume my experiences of venous thrombi, and the history of thrombus, they are to the effect that most venous thrombi are the result of very acute inflammation of cellular tissue, (especially under fasciae, or tense skin, and in bone), and that the coagulum undergoes the same metamorphoses as the inflammatory new formation. If the latter lead to formation of tissue, the thrombi are also organized to connective tissue ; if the inflammation goes on to suppuration or putrefaction, the thrombi also suppurate or putrefy and break down. This is the easier to understand, as we know, from Von Recklinghausen's and Subnoff^s investigations, that the cells from the tissue may pass through the walls of the vein into the thrombus. The walls of the vein have the same fate as the thrombus and sur- rounding tissue : they are infiltrated with plastic matter, and become thicker, or they suppurate. Thrombus, with phlebitis, may also run its course as a purely local disease, as not unfrequently happens after venesection, and in some other cases. Then there can only be further danger when the thrombus is friable, or when there is purulent or putrid destruc- tion of the coagulum. The central end of the thrombus (as we stated when speaking of arterial thrombus) usuallv extends to the THROMBOSIS, EMBOLISM. 359 Fig. 67. point where the next branch joins, and has a conical end, which projects a little (Fig. 67, a), and, if the coagulura loses its firmness, a portion of the coagulum may be torn off by the current of blood, and pass into the circulation ; this passes into the larger veins, thence into the right heart, thence to the pulmonary artery, in whose branches it is finally arrested at some point of bifurcation, as its size does not allow it to pass farther. This branch of the pulmonary artery is now closed by a clot of fibrine, as by a cork, a so-called embolus / the immediate consequence is a lack of blood in the parts of the lung previously supplied by the plugged artery. This local lack of blood (ischasmia of Virchoio) does not usually last long, but blood enters the empty artery from small collateral arteries ; it is true, blood may thus again enter the vein, but it comes from the small collateral branches, and flows very slowly, and may at last stop altogether, and coagulation extend back- ward through the capillaries even into the throm- bosed arterial branch. Thus, as a result of em- bolus in the artery, the whole corresponding vascular territory is thrombosed ; there may also be ruptures of the vessels, haemorrhages ; as the arteries of the lungs, spleen, and kidneys, con- stantly divide into smaller branches, and thus the vascular territory constantly enlarges toward the periphery, and resembles a cone with the apex in the organ, so the part in which the above coagulation occurs must be shaped like a Dia wedge or cone. In pathological anatomy these coagulations due to embolism have been called " red or hemorrhagic wedge-shaped infarctions." Frequently as these wedge-shaped infarctions occur, they are not a necessary result of embo- lism ; for, when the arterial collateral circulation is strong enough in the ischemic part to drive the blood through the capillaries, as is the case in otherwise healthy persons and in animals, as well as in emboli causing little mechanical or chemical irritation of the tissue, there is no infarction, at all events no considerable dis- turbance of circulation, but we have simply to consider the local processes around the embolus, as foreign bodies in the branch of the artery. These local processes depend on the character of the embolus ; if the latter be a pure fibrinous clot, there is a slight thickening of the wall of the vessel at the point where the embolus is gram : a, central end of a venous thrombus pro- jecting into a large trunk ; b, a branch with- out thrombus ; the blood flowing through it may detach and carry into the circulation the end of the thrombus a. 360 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. located (usually where the artery divides into smaller branches), and the latter may have new clots deposited around it, and be organized to connective tissue, or be reabsorbed. Should the embolus consist of a fibrinous clot impregnated with pus or putrid matter, it excites sup- purative or putrefactive inflammation, not only in the wall of the ves- sel, but also in the parts around. The metamorphosis of the red infarc- tion in part depends on its size, partly on the grade of the circulation still continuing in parts of it, and partly on the embolus causing the trouble. If the latter be innocuous and the infarction be small, or if it be still nourished by some vessels not thrombosed, the coagulum forming the infarction may again be dissolved, or else become organ- ized to a connective-tissue cicatrix. If the embolus be innocuous, but the thrombus extending completely through the whole infarction, the tissue and coagulum slowly disintegrate to a yellow, granular, dry pulp, which becomes encapsulated, and may calcify ; this is yellow dry infarctio?i. If the embolus be impregnated with putrid matter or pus, it excites putrid or suppurative inflammation all about it ; the in- farction also becomes putrid or purulent, and abscesses form. As we were just speaking of the lungs, we may here mention that these ab- scesses, which are usually peripheral, often excite pleurisy; that they are most frequently multiple in both lungs, and may even induce sup- puration of the pulmonary pleura over the abscess, and may thus occasionally cause pneumothorax. You can hardly imagine, gentlemen, what labor it costs to demon- strate this connection between venous thrombi and abscess of the lung, so that I can here announce it to you as a simple fact. You will read the classical works of Virchow, Panum, 0. Weber, and others, on this subject, with astonishment ; it would take too long for me to enter into the subject more fully ; we shall here assume the right of only taking the facts from these works. "We now understand lung infarctions and abscesses ; but how is it with those that occur under like circumstances, although much more rarely, in the liver, spleen, kidneys, and muscles ; are these also always dependent on emboli ? A few years since we could not have answered this ques- tion with certainty ; now we may affirm it. From experimental in- vestigations, especially those of 0. Weber, it is established that cer- tain forms of emboli, especially flocculi of pus, pass the pulmonary capillaries without difficult}^, may enter the left heart, and thence the systemic circulation, and be arrested in the spleen, liver, kidneys, or elsewhere, and cause abscesses. This explains the rare cases where, with venous thrombus, there are no abscesses in the lungs, while they exist in other organs. If, with abscesses in the lungs, there are em- bolic infarctions or abscesses in part supplied by the systemic circula- tion, they may be attributed to the formation of venous thrombi THROMBOSIS, EMBOLISM. 361 through the pulmonary abscess ; portions from these thrombi pass into the left heart, and thence farther. As regards liver-abscesses, JBusch has observed that retrograde movements of the blood from the right heart take place in the vena cava, and in this way hepatic emboli may occur. The embolic origin of metastatic abscesses is now so undoubted that, from the existence of one of these, we decide certainly on a venous thrombus undergoing putrid or suppurative liquefaction. The discovery of the connection may be easy in some cases, very difficult in others : very easy in cases of thrombus of large venous trunks, and embolism of branches of the pulmonary artery that may be readily reached with the scissors ; very difficult where there is simply coagu- lation in some small venous net-work (as in phlegmonous inflammation or decubitus) and embolism of capillaries of the lungs, spleen, kidneys, liver, muscles, etc. ; still, these latter cases are almost innumerable. On favorable objects (as in cerebral capillaries) it has been proved, beyond a doubt, that capillary emboli exist in some cases ; it is also certain that small veins become thrombosed in all suppurative inflam- mations ; it is very difficult, often impossible, to demonstrate this anatomically in every case. From what symptoms we conclude whether a coagulum is old or recent, will be taught you in the lec- tures on pathological anatomy. 19 Here we are only speaking of metas- tatic circumscribed inflammations, of infarctions, and abscesses ; these alone are connected with venous thrombi and emboli. For diffuse metastatic inflammations another explanation must be sought; we shall treat of this more under septicaemia and pyaemia. Nor shall we here discuss the question of fever in phlebitis and in the formation of metastatic abscesses. As phlebitis, with its results, so very often comes as an addition to already-existing acute inflammations, it is dif- ficult to judge how far it of itself excites fever ; metastatic abscesses, like all other points of inflammation, undoubtedly induce fever ; we should scarcely expect fever from a simple thrombus of the vessels. In dogs, by inducing numerous small emboli in the lungs by in- jecting flour or powdered coal into the jugular vein, we may, it is true, excite fever, as was shown by JBergmann, Strieker, and Albert; but this does not always occur in embolism in other vascular tracts, and possibly depends on increased action of the respiratory muscles. The treatment of phlebitis and thrombus is the same as that of lymphangitis and other similar acute inflammations. Careful frictions with mercurial ointment, or, if we fear detachment of the coagulum, covering the part with compresses smeared with mercurial ointment, or with bladders of ice, and absolute rest of the affected part, are indi- cated. Under pyaemia we shall speak of the diagnosis and treatment of metastatic abscesses. If phlebitis and thrombosis cause local sup puration, the abscesses should be opened as soon as recognized. 362 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. LECTURE XXVI. IT. — General Accidental Diseases which may accompany "Wounds and Local Inflamma- tions. 1. Traumatic and Inflammatory Fever ; 2. Septic Fever and Septicaemia ; 3. Suppurative Fever and Pyaemia. II -GENERAL ACCIDENTAL DISEASES WHICH MAT ACCOMPANY WOUNDS AND OTHER LOCAL INFLAMMATIONS. The local accidental traumatic diseases which we have so far de- scribed are always accompanied by constitutional disease, which is chiefly though not always feverish in its nature. Fever is such a com- plication of symptoms that it may seem very different according to the addition of one or other symptom ; now it is generally determined only to say that there is fever when the temperature of the blood is elevated, and to measure the intensity of the fever by the height of the temperature. I do not think it advisable to combat this position, for by abandoning it we should lose the common idea of what we call fever, and throw it back into the old chaos. But I must tell you that there are many and very dangerous general diseases in patients with wounds or other local inflammations, in which no change of tempera- ture of the blood can be discovered ; hence the latter is only condi- tionally a measure of the patient's danger. Besides the elevation of temperature, in fever we have the following chief symptoms : Increased rapidity of cardiac action and respiration, loss of appetite, frequently nausea, feeling of weakness, great sweating, not unfrequently trem- bling of certain groups of muscles (in chills), more or less mental excitement and blunting of the senses. Fever is a general disease, which may result from many causes ; in other words, the number of pyrogenous, like that of phlogogenous substances, is innumerable. According to the quantity and quality of these substances (which we term poisons) that have entered the blood, one or other set of symp- toms is more prominent : thus there is fever with very high tempera- ture, while all other symptoms are slight ; fever with great blunting of the senses, and but little elevation of bodily temperature ; fever whose prominent symptom is severe shivering, so-called chills ; fever with disturbance of the gastric functions, fatigue, etc., for the chief symptoms. Why, then, should we not have fever (a state of intoxi- cation caused by materials absorbed from wounds or points of inflam- mation) with all the symptoms, except elevation of the temperature of the blood ? From some cause or other this particular symptom might in some cases be concealed or prevented from appearing. But, as already stated, we shall accept the present view of fever, and only TRAUMATIC AND INFLAMMATORY FEVER. 363 suppose it to exist where we find elevation of temperature of the blood, but must then add that there are cases of severe general, accidental traumatic and inflammatory diseases which run their course without fever. But there is another common factor of these general diseases that we should bear in mind, viz., that they are all due to reabsorption of matters that form in the wounds or the parts around them, or (what is about the same thing) in a point of inflammation. On this point we agree with the present views, as far as concerns traumatic fever, in- flammatory fever, pyaemia, and septicaemia, less so perhaps as regards tetanus, delirium potatorum, delirium nervosum, and acute mania. But many important reasons favor the view of the latter diseases be- ing also of humoral origin ; hence I shall make no further divisions among the above diseases. 1. Traumatic and Inflammatory Fever. — It has been already explained (page 92) that the fever appearing in wounded patients is partly due to the blood taking up materials resulting from decompo- sition of mortified tissue on the substance of the wound, partly to the absorption of materials formed by the traumatic or accidental inflam- mation ; hence, in the latter case, the nature of the traumatic and inflammatory fever is perfectly obscure. On this supposition, which we previously tried briefly to prove, it will depend partly on the local advantages for reabsorption, partly on the quality and quantity of pyrogenous material in question, how great the poisoning will prove. There are cases where the vessels opened by the injury close so rap- idly, and the whole traumatic inflammation terminates so quickly, that there is no general infection or fever at first, and they may not occur at all ; such cases are i-re in extensive injuries, they are the ideal of the normal course ; in them the plastic infiltration on the edges of the wound leads quickly and throughout the wound to solid organized new formations, growing firmly in the edges of the wound, and pass- ing on to cicatrization immediately or after precedent granulation. If we assume this case as a normal type, every traumatic fever is a pathological accident. We must acknowledge this in theory, but in the great majority of cases, in wounds of any size, fever occurs sooner or later ; hence we considered it advisable to treat of traumatic fever in the previous description of the general condition of the wounded pa- tient. We have still, however, to add something to what was then said, which at that time it would have been difficult for you to under- stand. Let us first speak of the period at which traumatic fever usually appears, and of its course. In many cases, especially where the injury has affected tissues previously healthy, the fever does not begin till the second day, increases rapidly, and, with evening remis- 364 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. sions, remains for some days at a certain height, and then ceases gradually (rarely within twenty-four hours). According to my very numerous observations, in far the greater majority of cases the trau- matic fever begins within two days after the injury. This fever is usually represented graphically as follows : Fig. 68. Day of the Disease. 1. 2. 3. 4. £ e. 7. $. A A -39— / -M Mfir P\ X 7 r 7~\ ■&— 1 \ / \ ■V—^ \/ \ Y N fyo A j \ z/ S / v. \/~ oy \ Of %/! Z OVfd If ifb Po\ er-curve after amputation of the ana. Recovery. This and the following fever-curves are arranged on the scale of Celsius's thermometer. Each degree is divided into ten parts, the horizontal divisions indicate the day of the disease ; the curve is made according to the morning and evening measurements ; the two heavy lines indicate the maximum and minimum normal temperature of a healthy person. The curve shows that, after an amputation of the arm, rendered necessary by an injury (measurement was accidentally neglected the first day), the fever did not begin till the third day, then continued from the fourth to the seventh day ; after the eighth day the patient remained free from fever. In other cases, however, secondary fever often occurs immediately after amputation. Such an occurrence of traumatic fever is quite frequent. I explain it as follows : Immedi- ately after the injury the tissue of the edges of the wound was closed by infiltration of plastic matter ; the third day this commenced to break down into pus, and to mingle with decomposed shreds of tissue on the surface of the wound, thus inducing a moderately extensive inflammation of the amputation stump, with reabsorption of pus and other products of decomposition and inflammation ; this reabsorption goes on till checked by some mechanical cause (diminished pressure. TRAUMATIC AND INFLAMMATORY FEVER. 365 thickening and partial closure of the vessels, etc.). In other cases, the fever begins the very day of the injury ; we see this when blood has been enclosed between the flaps of the united wound and it has rapidly decomposed; frequently, also, when operations have been done in tissues infiltrated with the products of chronic infiltration. The following case (Fig. 69) may serve as an illustration of this second class : Fig. 69. Day of the Disease, 1. 2. 3. 1, 5. 6. 7. 8. | Z9,5 1 i ! j\ 1 39 \ H / \ / \ / \ ' \ / \ \ / y $B,5 V / \ i \ ' 1 \ ^* • L^\ i 1 - s 3$ ^ / K / \ \ / \ i V i 1 i !^— 4 tr W\ — A-i— -7---I ns \ / ^ / M /I \ / i 11/ 37 \ / \ / \ / 'V / V \ / 1 \/ 1 V — h* ! ZG,5 ~u j ; i i i i Z6 ! i 1 Fever-curve after resection of a carious wrist, with great infiltration of the soft parts. Recovery. In infiltration of the tissue from chronic inflammation, the finer lymphatic capillaries may be contracted and to some extent closed, and hence, for some time, may not have carried off sufficient serum from the tissue, but the medium-sized lymphatic vessels, like the cor- responding veins, which in chronic inflammation have long been ex- posed to high pressure, are undoubtedly distended, perhaps even gaping, from rigidity of their walls ; hence, if not quickly filled with firm plastic infiltration from the start, they take up a good deal of the secretion from the wound ; moreover, on the edges of wounds in mor- bidly-infiltrated tissue, mortification is particularly apt to occur. This explanation of the late and early occurrence of traumatic fever is purely hypothetical ; but it is taken from and has been induced by numerous observations. It might also be assumed that in one case 366 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. the ferment absorbed into the blood acted very slowly, in another very quickly ; nothing definite can be said on this point. As I for- merly believed that the fever was always caused by nervous irritation, it was necessary to suppose that this irritability was varied, and hence the febrile effect might occur at very different periods, but I have en- tirely abandoned this theory, without undervaluing the important part played by the nervous system in the origin and symptoms of fever. Traumatic fever usually lasts a week ; it is rarely longer, without some visible local complication. When there is an accidental inflammation of the cellular tissue, lymphatic vessels, or veins, about a wound, fever occurs simultaneously with this inflammation, or apparently precedes it (coming as an in- flammatory secondary fever, either immediately after the traumatic fever or when several or even many days have passed without fever). I say it apparently precedes, because the first signs of the local affec- tion may have escaped us, as they may possibly have presented no sensible symptoms, or because the poisonous material may have in- fected the blood sooner than it did the parts immediately around ; the probability of the latter idea is based on the fact that poison, taken into the lymphatic vessels or veins with the lymph or blood, flows more rapidly in the centre of the vessel than along its walls, and thus quickly reaches the large blood-vessels, while the fluid, moving more slowly along the walls of the vessels, only gradually passes into the perivas- cular tissue, and there induces inflammation by the phlogogenous poi- son it contains ; thus fever (the blood-infection) may appear before erysipelas, lymphangitis, or phlebitis (from the local infection), is per- ceived. The course of this secondary fever entirely depends on that of the local inflammation ; as the latter begins, the temperature rises rapidly, often with an initial chill. The longer these secondary fevers continue, that is, the longer the poison is kept up, the more danger- ous the condition becomes ; rapid emaciation, great sweating, sleep- lessness, and continued loss of appetite, are bad symptoms ; usually in these secondary fevers there is absorption of pus or infection from without. Pronounced erysipelas or inflammation of the lymphatic vessels or glands are the relatively most favorable forms of the acci- dental inflammations, as sooner or later they generally lead to a certain usually favorable termination, and thus are somewhat typical in their course, although the duration of an erysipelas may vary from three days to three weeks or more, and prove very debilitating ; at first the fever-curve rises rapidly, then remains for a time at a certain height, usually with morning remissions ; not unfrequently the temperature falls rapidly ; the same is true of lymphangitis. Fortunately, it is rare for lymphangitis and erysipelas to extend deep into the cellular tis- sue and under the fasciae ; in such a case the disease would be classed TRAUMATIC AND INFLAMMATORY FEVER. 367 among the severer inflammations, and would lose its somewhat typical character. In diffuse, deep inflammation of the cellular tissue, with or without venous thrombosis, the fever does not begin so suddenly, but, from the first, always has a decidedly remittent type, and, like the local affec- tions, is incomputable in its further course ; the loss of strength, the Fig. 70. Day of the Disease* 1. 2. 3. x 10. 3%5 S 39 38J m 38 £ 2£ 37J 37 ^ 36J 3G Fever-curves in erysipelas traumaticnm ambulans faciei, capitis et colli, following extirpation of a cancer of the lip. Recovery. emaciation, sweating, sensitiveness, and excitability of the patient, attain the highest grade. Intermittent fever and metastatic inflam- mations, the chief symptoms of those malignant traumatic fevers which we call " pyaemia," are greatly to be feared in such cases. In all these fevers the quantity of urea is increased and exceeds the amount of nitrogenous food consumed ; at the same time, accord- ing to recent investigations, the weight of the body diminishes con- siderably. As long as the constitutional symptoms, especially those due to the fever, do not extend beyond the above, and especially if the dis- ease does not prove fatal, we are generally satisfied with the terms " traumatic, suppurative, or secondary fever." But, if other symptoms occur, and death results, these severer infections have two other names, " septicaemia " and " pyemia." We follow this common classi- fication. 368 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. 2. Septic Fever (Septicaemia). — By septicaemia, we understand a constitutional, generally acute disease, which is due to the absorption of various putrid substances into the blood, and it is thought that these act as ferments in the blgod, and spoil it so that it cannot fulfil its physiological functions. This disease may be induced in ani- mals by injecting putrid matter into their blood or subcutaneous tis- sue, and it has been found that large animals (large dogs, horses, etc.) may, under certain circumstances, live through the putrefactive blood- poisoning, although it makes them very sick. Certain circumstances are necessary for putrid matter to be taken into the blood of man ; such substances are only taken through the healthy skin and mucous membranes when the putrid substances have a destructive or cauter- ant action, or an active power of penetrating, like fungi and infusoria. Diseased skin or wound surfaces take up such putrid matters more readily, but even they only do so under certain circumstances ; for instance, they do not readily pass through well-organized, uninjured granulations. If we dress a nicely-granulating wound on a dog with charpie dipped in the filthiest putrid matter, if the latter contain no cauterant substance that may destroy the granulation surface, the ani- mal will not sicken, nothing will be absorbed. Hence I conclude that the poison must in some way be prevented from entering the blood- vessels in the surface of the granulations. If the septic poison be in- troduced into the fresh tissue, it not only excites severe local inflam- mation, but quickly induces general fever. From these peculiar con- ditions under which infection from putrid substances usually takes place, it seems to me evident that the poison is absorbed chiefly by the lymphatic vessels, as I have already mentioned. Remember, also, that, in contused wounds, decomposing shreds of firm connective tis- sue, especially of tendons and fasciss, often lie for a long time on granulating wounds, without any septic poison passing from them through the superficial vessels of the granulations into the blood ; this observation verifies the experiments made on dogs. But, if the poison be not taken up by the blood-vessels, or be taken only under certain circumstances, it is very probable that its absorption is chiefly through the lymphatic vessels. I will not deny that possibly in certain swol- len states of the walls of the blood-vessels, as well as from capillary attraction, and also through the thrombi of the vessels, infectious mate- rials may reach the blood, nor that cells take up septic molecular substances and may wander with them into the blood-vessels ; but, on the whole, I consider this mode of infection the exception, especially if the infectious substance be not dissolved, but exist as very fine molecules ; if, for instance, it be taken up in the form of dust. Of the healthy parts of the body exposed to the air, it has only been proved SEPTICEMIA. 369 that dust-like bodies (as coal-dust) enter the lungs, and may thence reach the bronchial glands (thence also the blood), while a similar absorption from the walls of the intestines has not yet been observed or experimentally proved. Should the miasmata really be small fungi, that is, molecular bodies, from what has been said, it would seem very probable that the infection may take place through the respiration ; if this should be proved, it might be of great practical consequence. Of late, many attempts have been made to determine what sub- stance in decomposing animal tissue is the true poisonous principle, and for this purpose putrid fluids have been treated chemically till some one body should be found which in the smallest dose should ex- cite the symptoms of septic poisoning. Thus JBergmann has produced a body of this nature from decomposing yeast, which he calls sepsin. To prove that this body alone, (whose presence Fischer could not prove in decomposing serum or pus) is the poison, it would be neces- sary to prove the innocuousness of all other bodies chemically formed during putrefaction. But this cannot be done ; sulphuretted hydro- gen, sulphuret of ammonium, butyric acid, leucin, and some other sub- stances, forming during the putrefaction of organic bodies, also act as septic poisons when injected into the blood ; so that I cannot enter into the laborious search for one body in the putrid fluids which shall bear all the blame of the injurious effects. It is very probable that in decomposing fluids, according to their qualities, degree of concentration, temperature, etc., very many different poisonous sub- stances may form, which I further imagine as going on changing till they reach some final terminal stage. Whether this terminal stage is always the same is still to be de- termined. This is not the place to discuss such difficult questions exhaustively ; so far as my experience, observations, and studies go, I consider it at least probable that the septic matters are formed in the inflamed and gangrenous tissues, and pass to the blood as a de-* veloped poison. Opposed to this view is another, that only a fer- ment goes to the blood from the tissues (ultimately from the air), which soon causes fermentation or decomposition (O.Weber). Ac- cording to this, the absorbed septic matters would not be in them- selves poisonous, but would develop poison in the blood from its components. Of late this hypothesis is rendered more precise by asserting that the ferment is coccus or bacteria (monads of Hiceter). I cannot agree to this, for I have never found micrococcus in the blood of pa- tients who afterward died of septicaemia, or who had already died of it. I must add that some time after the injection I could not find these organisms in the blood of dogs into which I had injected putrid 24 370 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. fluids with coccus and bacteria, and which died of septic poisoning ; nor could I find them some hours after death. Hence, it seems as if coccus and bacteria not only could not grow in living blood, but soon disappeared from it. According to these observations, it is not justifiable to suppose that septicaemia is a haematozymotic process due to organisms, which, from analogy with fermentation, must be based on an enormous vegetative energy of the vegetable ferment. Numerous investigations on these highly interesting scientific ques- tions have failed to give a full explanation. From the works of A. Hlller and E. Anders, it seems certain that the putrid poison ad- heres not only to the microscopic organisms, but is found also dis- solved in the poisonous fluids, although not so constantly. Particu- larly interesting are the experiments of A. Hiller, in which the blood of a rabbit which was killed by putrid fluid free from bacteria killed another rabbit into which it was injected, and increased in poison- ous effect with each succeeding injection. According to previous views, this could only be explained by the presence of a constantly renewing and increasing inanimate ferment. When Davaine first published the same experiments made with fluids containing bac- teria, and they were confirmed by Strieker, it was considered almost certain that the results were only explicable by a living ferment; now this view is rendered less imperative by the above experiments of Hiller. At all events, in future investigations more attention must be directed to distinguishing " septogenous ferment " from " septic poison," the final product of fermentation ; this may cost much labor. It is very possible that in some animals the septoge- nous ferment may at the same time be a septic poison. After these general observations, we shall consider those surgical cases that give rise to septic infection. First come the cases where there is decomposition on recent wounds ; it usually appears within the first three days whether in such cases there will be intense, un- usual, loeal, and general infection. If the local infection merely evince itself in moderate inflammation, which soon leads to circumscribed suppuration, if the general infection be followed by moderate fever, the affection would come under the head of traumatic fever. But if the local infection be very extensive, with phlegmonous inflammation and putrefaction, and the general condition assume a character soon to be described, we call the state septicaemia. In other cases the re- absorption of putrid matter takes place from a traumatic or idiopathic extensive gangrenous spot (as from gangrene due to disease of the arteries) ; this is more frequently the case in moist than in dry gan- grene. In the same way the requirements for the reabsorption of putrid substances exist, if after delivery the placental surface of the SEPTICEMIA. 371 uterus becomes gangrenous ; some of the cases of puerperal fever are septicaemia. It will be evident to you that the term septicaemia essentially de pends on the etiology, just like the group of "typhous" diseases; and that mild septic-traumatic fever has the same relation to septi- caemia that typhus febricula has to typhus ; in fact, the name " septic febricula" has been proposed. Still, as typhus in its different forms is characterized by its symptomatology and pathological anatomy, this is also the case in septicaemia, although in it the pathologico-anatomical appearances are slight. Now, what characterizes the course of septi- caemia ? The nervous symptoms deserve the first mention : the patients are apathetic and sleepy, if not entirely comatose ; rarely there is fear- ful excitement, and occasionally maniacal delirium ; at the same time the subjective feelings are good; the patients do not suffer much. The tongue is dry, often as hard as wood, which renders the speech very Fig. 71. ij Day of the Disease, 1 1. 2. 3. L 5. G. 7. 8. 9. 10. 11. M *- ft ZS,5 39 — R i I m k — a • $7,5 j \ i i i » i ! ! ' ■ j ! 1 3Y b'36,5 r ■ i i \ *\ \ Death; \ : 36 Jill till i i i i ^^ Fc-ver cur,e iD eefrioimia af&rr extirpation of an immense lipoma, from between the muscles of tho thigh. Death. peculiar; the patients are thirsty, but rarely drink, on account of their ivreat apathy. Not always, but very frequently, there is profuse diar- rnnea, more rarely vomiting. At first there may be great sweating, 372 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. later the skin is dry and flabby. The urine is scanty, very concen- trated, and occasionally albuminous. As the disease progresses, the patient passes his urine and faeces in bed. Bed-sores over the sacrum occur early. The fever (as shown by the bodily temperature) at first rises high ; in acute pure septicaemia intercurrent chills never occur in the course of the disease, and initial chills are very rare. In the prognosis of septicaemia the conditions of the pulse and tongue are more important than the temperature, A small frequent pulse and dry tongue are bad signs ; while a normal temperature has no prognostic value, very high or very low temperature makes the prognosis worse. This is the usual course of acute pure septicaemia from recent in- juries ; but the patient may die in the first stages, with rising tempera- ture. Cases also occur where the onset of the fever is scarcely marked by an elevation of temperature, and lastly some cases run their course without fever or with abnormally low temperature; the latter occurs especially in old persons with spontaneous gangrene ; but the other symptoms above mentioned usually exist. From this and particularly from the above curve, we see that failing of the temperature of itself is by no means a sign of improvement, but that the other constitutional symptoms (strength, mental state, tongue, pulse, etc.) must also be taken into consideration. 20 I hope that, from what has been said, you have formed a true idea of septicaemia. Where the symptoms of the disease are marked, the prognosis is very bad ; we shall speak of the treatment at the end of this section. We now come to the post-mortem appearances. Occasionally it is difficult for us to recognize on the cadaver the ©edematous infiltration and brownish discoloration of the skin that we observed about the wound during life. In other cases that had a long course (six to eight days) we find the subcutaneous tissue infiltrated with bloody, serous fluid ; wiiere the course is still longer (two weeks or more) the disease shows itself mostly by extensive suppuration of the cellular tissue, vith more or less extensive gangrene of the skin. Frequently the in- ternal organs present no morbid appearances. If there was continued profuse diarrhoea during life, you find swelling of the solitary and conglobate intestinal follicles. The spleen is often enlarged and softened, rarely it is of a normal size and firmness ; the liver is usually full of blood, relaxed, and very friable, but without further change. In the heart the blood is lumpy, half-clotted, tarry, and rarely firmly coagulated, buffy ; in most cases the lungs are normal. Sometimes we find diffuse single or double pleurisy of moderate extent, and also traces of pericarditis. Under pyaemia w r e shall speak more fully of these diffuse metastatic inflammations wdiich are not due to emboli PYAEMIA. 373 here it is not very necessary to do so any more than it is to treat of embolic infarctions and putrid abscesses, which are exceptionally found in septicaemia when the patients resist the disease a long time, and venous thrombi have occurred about the wound or gangrenous spot. As nothing special has been found on chemical analysis of the blood from the bodies of such cases, it must be acknowledged that what we find postmortem adds little that is characteristic to the picture of the disease, which is essentially etiologico-symptomatological ; if we have not seen the patient during life, we shall often examine the dead body in vain for some palpable cause of death. 21 3. Suppurative Fever, Pyozmia. — Pyaemia (the name was formed by Piorry from ttvov, pus, and alfia, blood) is a disease which we suppose to be due to the absorption of pus or its constituents into the blood; it holds the same relation to simple inflammatory and suppurative fever that septicaemia does to simple primary traumatic fever; it is symptom atologically characterized by intermittent attacks of fever, and in its pathological anatomy by the frequency of metastatic abscesses and metastatic diffuse inflammations. Other names for this disease are : metastatic suppurative dyscrasia, pus disease, purulent diathesis. To give you at once an approximate picture of this disease, I will describe for you a case of pyaemia. A wounded patient enters the hospital with a compound fracture of the leg just above the ankle. The injury has resulted from the fall of a heavy body. You examine the wound, find an oblique frac- ture of the tibia, but consider the injury of such a nature that it may heal. So you apply a dressing ; at first the patient feels very well ; he has but little fever till about the third or fourth day, then the wound becomes more inflamed, secretes relatively little pus, the sur- rounding skin becomes cedematous and red, the patient grows very feverish, especially toward evening, the swelling about the wound in- creases and slowly spreads, the whole leg grows swollen and red, the ankle-joint very painful ; on pressure over the leg, a thin, bad-smell- ing pus flows slowly from the wound ; the swelling remains limited to the leg ; there is no trouble of the mind, no sign of intense, acute septicaemia ; the patient is exceedingly sensitive to every dressing, he is restless and discouraged ; there is febris continua remittens, with high evening temperature, and frequent, full, tense pulse ; the appe- tite is lost, and the tongue heavily coated. This would be about the twelfth day after the injury. Quantities of pus flow from different parts of the wound; somewhat above it fluctuation is distinct; this collection of pus may be evacuated through the wound by careful press- ure, but the escape is greatly impeded, and an incision must be made at the above point. This being done, a moderate quantity of pus is 374 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. evacuated ; a few hours later the patient has a severe chill, then dry burning heat, and, lastly, profuse sweating. The appearance of the wound improves somewhat ; but this does not last long ; we soon no- tice a new abscess near the wound, but rather behind it in the calf ; there is another chill ; more counter-openings are required at different spots to give exit to the pus, which forms in quantities. The left leg is the injured one ; some morning the patient complains of great pain in the right knee-joint, which is somewhat swollen, and is painful on every motion. The nights are sleepless, the patient eats very little, drinks a great deal, and becomes much debilitated; he emaciates, especially in the face, the color of the skin changes to yellowish, the chills recur ; the patient then begins to complain of pressure on the chest ; he coughs some, but raises little sputum ; on examining the chest, you find a moderate pleuritic exudation on one or both sides, from which, however, the patient does not suffer much, but he com- plains more of the right knee, which is now much swollen, and con- tains a great deal of fluid ; as the patient sweats a great deal, the urine becomes very concentrated, and is occasionally albuminous. Finally, there is decubitus, but the patient does not complain much of this ; he lies quietly, half insensible, muttering to himself. This would be about the twentieth day after the injury ; the wound is dry, the patient looks miserable ; the face, and especially the neck, is ema- ciated, the skin is very jaundiced, the eyes dull, the trembling tongue is perfectly dry, the skin cool, the temperature low, and only elevated at evening, the pulse small and frequent, the respirations slow, the breath of a peculiar cadaveric odor ; the patient becomes entirely un- conscious, and may, perhaps, remain so for twenty-four hours before death. On aittopsy, you find nothing pathological in the skull ; heart and pericardium normal ; in the right auricle and ventricle a firmly-coagulated, white, fibrinous clot ; both pleural cavities are filled with a cloudy, serous fluid ; the surfaces of the lungs are covered with a net-like layer of jaundiced fibrine ; on tearing this off, under it, in the substance of the lung, but particularly on its surface, you find quite firm nodules, as large as a bean or chestnut. These are found chiefly in the lower lobes ; sections through them show that they are mostly abscesses. The parenchyma of the lungs, somewhat condensed, forms the capsule of a cavity, which is filled with pus and disintegrated lung-tissue ; others of these nodules are bloody red, and, on section, the cut surface is somewhat granular, and in their midst there are oc- casional spots of pus of various size, and it is evident that they change to abscesses. They are the red infarctions, terminating in abscesses, with which you are already acquainted. Some of these abscesses lie so near the surface that they implicate the pleura, and PYEMIA. 375 the pleuritis is secondary. The liver is quite vascular and friable, but is otherwise apparently normal. The spleen is somewhat enlarged, and, on section, shows a few firm, wedge-shaped nodules, with their points inward, and their broad outer ends along the surface ; they re- semble the red infarctions of the lungs, and within they also have partly broken down into pus. The intestines, urinary and genital organs, show nothing abnormal. An incision into the right knee, which was painful during life, evacuates a quantity of flocculent pus ; the synovial membrane is swollen, and in part hemorrhagic, injected ; the lustre of the articular cartilage is dulled. Examination of the wound shows little more than we found on the living patient ; that is, extensive suppuration of the deep and subcutaneous cellular tissue, as well as pus in the ankle-joint ; the walls of all these collections of pus consist mostly of broken-down tissue, true granulation has only oc- curred at a few points. The fracture is, however, more complicated than had been supposed, for a longitudinal fissure reaches to the ankle-joint, and on the posterior aspect of the tibia, which we could not examine during life, there are several detached fragments of bone. In the veins of the leg there are old plugs of fibrine here and there, also yellow puriform detritus, and in some places pure pus. Let us make some reflections on this case, and suppose that you have seen a series of such cases, so that you are convinced that it is not an accidental association of various diseases, but a regular com- bination. You have an extensive, steadily-increasing suppuration in an extremity, with intense continued fever, which has exacerbations. To this are added suppuration in some distant joint, and circumscribed inflammations, ending in formation of abscesses in the lungs and other organs. These multiple points of inflammation keep up the fever, and they disturb the functions of the affected organs, and the patient dies of exhaustion. The peculiar and essential feature, as you will readily see, is the appearance of various points of inflammation, after the primary suppuration has attained a certain grade. You know the explanation of the occurrence of metastatic abscesses : they are al- ways caused by venous thrombosis and embolism ; it is unnecessary to recur to this. It is more difficult to explain the diffuse metastatic inflammations which occur both in septicaemia and pyaemia ; they by no mesjis always depend on abscesses of the lungs, as does pleurisy in the cases above mentioned ; there are metastatic diffuse abscesses of the eye, cerebral membranes, subcutaneous tissue, joints, periosteum, liver, spleen, kidneys, pleura, pericardium, etc., which are independent of abscesses or emboli. The occurrence of these metastases cannot always be exactly explained. If the metastatic disease be nearly united to the original abscess, it might be attributed to conduction 376 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. of the inflammation from the latter, possibly through the lymphatic vessels ; as in cases where, after amputation of the breast or exar- ticulation of the humerus, there is pleurisy of the same side, or a fracture of the lower third of the leg is accompanied by suppuration of the knee-joint. In other cases it is possible that a part already diseased, or predisposed to inflammation, becomes acutely affected, as a result of the general febrile disturbance ; for instance, sometimes fracture callus, say of the radius, that is already tolerably firm, sup- purates in the third or fourth week, if the patient becomes pyemic from a complicated fracture of the leg, or from a bed-sore. Bat there are many cases where, as above stated, such explanations prove insufficient. Then we try to satisfy ourselves that there was a predisposition to in- flammations, especially to suppuration in certain organs, which is necessarily accompanied by pus-poisoning ; that the pus-poison circu- lating in the blood has a specific phlogogenous action on certain organs. I can give you no farther explanation on this point, but would like to render this hypothesis a little more plausible to you, by comparing it with analogous observations on the specific phlogogenous action of certain drugs, of which we have already spoken when treating of the etiology of inflammation, and its toxic-miasmatic causes, and their mode of action (page 268). Diffuse metastatic inflammations of in- ternal organs are rare,- unless among them we include the diffuse en- largement of the spleen, which is frequent, if not constant, in pyaemia. The diagnosis of metastatic abscesses and inflammations is easy, where the}' lie at the surface of the body and extremities ; metastatic me- ningitis or choroiditis is relatively easy to recognize. The diagnosis of metastases to the lung may prove difficult ; the foci are often so small and so scattered in the lung that they cannot be detected by percussion; the accidental pleuritic effusion often aids in the diagnosis of metastatic pulmonary abscesses ; if there are bloody sputa and severe bronchial catarrh, the diagnosis may be considered certain ; the subjective symptoms are often very slight ; the dyspnoea is only severe when there is extensive pleuritic effusion. In pyaemia there is often more or less jaundice. It is not yet fully determined whether, in these C3 ses, the coloring matter of the bile is formed from the red coloring matter of the blood without the intervention of the liver, or if icterus ever can occur without the liver having something to do with it, al- though most observers regard it as always being hepatogenous. At all events, icterus in pysemia does not admit a diagnosis of abscess of the liver ; this may be suspected if there be great pain in the hepatic region, but, instead of the expected hepatic abscess, I have, in such cases, occasionally found acute diffuse softening of the liver, which was accompanied by almost bronze-like icterus. Enlargement of the PYAEMIA. 377 spleen may sometimes be diagnosed by percussion. Occasionally, albumen, with epithelial and gelatinous casts and blood in the urine, especially if there be considerable coincident decrease in the amount of urine excreted, justifies a diagnosis of acute metastatic nephritis ; but during life it cannot be certainly determined whether the kidney has numerous metastatic abscesses or is diffusely inflamed, as may also occur metastatically. Pulmonary and splenic abscesses, as well as articular inflammations, are the most frequent, while those of the liver, kidneys, and other parts above mentioned, are far more rare. There is one symptom of pyemia that we must study more care- fully, viz., chills. They occur irregularly, rarely at night, although they may come at any time of day, and their duration and intensity vary exceedingly ; sometimes the patient only complains of slight cnilliness and temporary shivering, sometimes he trembles and chat- ters his teeth as hard as in " chills and fever." At first the chills come rarely, then more frequently, two or three times daily ; toward the end they again abate. The attacks themselves resemble those of intermittent fever in regard to chill, dry heat, and sweating ; but after the attack there is no complete cessation of the fever, it almost al- ways continues to some extent. Now, what is the true nature of this chill ? When we have opportunity to make observations on ourselves we find that there is a spasmodic contraction in the skin ; we must spasmodically knock the teeth together, even against our will ; if this ceases for a moment, we do not feel cold, but rather hot, and the feeling of chilliness is more in the imagination, for otherwise we only have similar sensations and spasmodic trembling as an effect of great cold. During the chill the limbs and skin feel cold, as the blood has been driven from the capillaries by the spasm of the cutaneous mus- cles. But if you measure the bodily temperature with the thermom- eter from the commencement of the chill, you find that the tempera- ture rises constantly and rapidly, occasionally from 3° to 5° Fahr., in a quarter or half an hour. At the end of the chill, and during the period of dry heat, the bodily temperature usually attains its highest point ; it may reach 108° Fahr., but rarely goes over 104.5° Fahr. ; from this point it gradually declines. The rapid increase of temper- ature is always in proportion to the phenomena of the chill ; a cer- tain irritability of the nervous system also appears necessary for its occurrence, for in torpid or narcotized persons chills are much more rare than in very irritable subjects (see page 171). The most varied acute diseases begin with chills and fever, espe- cially the acute exanthemata, pneumonia, lymphangitis, etc. ; more rarely the acute miasmatic infectious diseases, such as typhus, plague, 378 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. and cholera. Usually, however, these chills are not repeated, but only the onset of the disease is accompanied by this symptom ; it seems as if the first entrance of certain pyrogenous substances into the blood of persons otherwise healthy was especially apt to induce chills, or as if certain infectious materials entering the blood excited particularly intense fever with chills. Hence, although we cannot consider chills a characteristic of pyasmia, still their frequent recur- rence, as well as the generally intermittent type of the fever, is pecu- liar to this disease. Intermittent fever is the only disease in which we see any thing similar ; there we have intermittent attacks of fever with regular intervals ; we do not koow on what this interval depends, but I should consider the immediate cause of the attacks of fever to be paroxysmal pouring out of morbid products from the spleen ; in melanasniia and pigment metastases we have anatomical evidence that in intermittent fever substances pass from the spleen into the blood ; it is known that collections of normal secretion occur in the pancreas and spleen, and are poured out during digestion ; hence, it does not seem to me too bold to assume that, with these physiological evacuations of certain substances from the spleen, pathological prod- ucts may also enter the blood. Thus, in pyaemia, from time to time pus or its constituents might be poured into the blood, and under otherwise favorable circumstances fever and chills might be induced. Extensive progressive inflammation about the wound must be re- garded as the chief source of such repeated purulent infection ; destruction of the granulating surface by frequent injury, rapid de- struction of the granulations by chemical agents, any new progressive inflammations occurring about the wound, may open an entrance for the pus into the lymphatic vessels which have been closed ; new in- flammation may cause suppuration of the coagula in the lymphatic vessels, and the pus from these may enter the blood ; it might also be imagined, although difficult to prove, that in venous thrombosis the central coagula enclosing the pus in the veins are torn loose, and the pus is swept into the blood through a passable collateral vein, which opens farther on ; this might be caused by muscular contractions. Lastly, metastatic inflammations, whether due to emboli or not, also induce new attacks of fever ; but that this is not the only cause is proved by occasional autopsies on cases that have died from intermit- tent purulent fever, after ten or twelve chills, where no metastatic inflammations have been found; the cause of the repeated chills may then lie in the mode of extension of the local process, or be hidden in the bones or elsewhere. Statistics greatly favor the idea that the chills depend on new inflammations, for they show that the chills (or at least the intermittent fever attacks, which may occur without PYAEMIA. 379 chills) occur far more frequently in persons in whom subsequent autopsy shows inflammation of internal organs than in those where this is not the case. It must be mentioned, as a matter of observa- tion, that chills occur almost exclusively in the commencement of acute inflammations, and are intermittent only in intermittent fever and reabsorption of pus, while they do not occur in acute septicaemia. Probably the chemical qualities of the infecting matter here play an important but unknown role. Unfortunately, experiment here leaves us entirely in the dark ; I have never succeeded in exciting chills or intermittent attacks in rabbits, dogs, or horses, by injections of putrid substances or good pus ; pus and putrid matter have the same ac- tion on animals, as regards fever ; we can only artificially excite the intermittent course of the fever in animals by repeating the injec- tions. From what you have just heard, you will understand that the usual method of measuring temperature morning and evening can give no picture of the course of the fever in pyaemia ; for in this way the measurement may fall at one time in the acme, again in the deferves- cence of an attack of fever, or at another time in the remission (com- plete intermission of the fever rarely happens in pyaemia) ; thus we would of course have very irregular fever-curves. To obtain an ac- curate picture of pj^aemic fever, it would be necessary to leave the thermometer constantly in position, and to note the temperature every hour or so ; as this would greatly annoy the patient, and we have enough other signs to decide the prognosis and treatment, I have been unable to make up my mind to do this. The investiga- tions as to whether pyemic pus contains peculiar substances, or its qualitative composition differs from that of the pus in persons who recover without any complications, have thus far proved without re- sult. The pus of pyaemic patients does not always smell bad, nor always contain cocci ; still cases where putrid pus containing- cocci enters the circulation are the more frequent. We do not know whether the pus coccus grows after entering the blood. I have not found cocci and bacteria in the blood of pyaemic patients. The mode of onset of pyaemia varies in some respects. Most fre- quently this disease, which we regard as a peculiar, malignant form of suppurative fever, begins when suppuration begins, or later, when new inflammations occur about the wound, whether they be imme- diately connected with the traumatic inflammation, or occur acciden- tally after the point of traumatic inflammation has been bounded. Then the pyaemic fever develops from the traumatic fever, or from the secondary fever, and in such cases these are considered by some ob- servers as prodromal stages of pyaemia. The moment when the pa- 380 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. tient becomes pyemic cannot be decided any more accurately than can the passage of primary traumatic fever into septicaemia. I retain the designation " pyaemia " for the disease just described. I have told you that the reabsorption of pus is the cause ; intermittent course of the fever, with rapidly-increasing marasmus, the chief symptom ; and the metastatic inflammations very essential anatomical conditions ; but it is sometimes very difficult to decide whether a given case shall be termed severe traumatic fever, septicaemia ; or severe suppurative fever, pyaemia. The chills may not occur ; then it is difficult to de- termine the intermittent course of the fever ; the metastases may not be diagnosticated during life. If you have a case of osteomyelitis with frequent chills, if the patient dies and you find no metastases, is that pyaemia ? Or an old marasmic man has a compound fracture ; he dies with symptoms of complete exhaustion in the fourth week, with- out having had very high fever or chills ; you find no metastases ; is that pyaemia ? For the beginner who would like to have every thing well systematized, these questions, and their doubtful answers, are very embarrassing. You will find surgeons who call the above cases pyaemia, others who term them simply intense suppurative fever or febrile marasmus. If you adhere to the above description, and have correctly comprehended the relation of infection to venous throm- bosis and embolism, it is to be hoped you will not be perplexed about the names. Indeed, it is scarcely possible to make a name for every link between septicaemia, purulent infection, diffuse metastatic inflam- mations, thrombosis, embolism, etc. For instance, septicaemia occurs without a trace of metastases, with diffuse metastases, with throm- bosis and embolism ; purulent infection without a trace of metastases, with diffuse metastases and thrombi, with thrombi alone, with thrombi and emboli ; there are thrombi with local sequences without emboli, with emboli, with haemorrhagic effusions, with apoplexies, etc. Be- sides the words already given, some others have been introduced to designate combinations of the various processes. For pure purulent infection (infection with thin, bad pus — ichor) Virchow has proposed the name ichorrhwmia. O. Weber uses the name embolhcemia for the condition in which emboli are found in the blood. The classification given by Heuter, in his excellent work on this subject, appears to me very practical. In pure cases of purulent infection without metastases he calls the disease "pyohaemia simplex;" in cases with metastases, " pyohaemia multiplex." The course of purulent infection is usually acute (8-10 days), often subacute (2-4 weeks), rarely chronic (1-3-5 months). The ra- pidity of the acute cases is due partly to the intensity and frequent repetition of the infection, partly to the extent of the metastases PYEMIA. 381 The chronic cases usually occur in very strong or tough patients, and the infection is only moderately intense, and not often repeated ; the metastases are in external parts, as abscesses in the cellular tissue, and suppurations of the joints, which keep the patient sick after the other results of purulent infection have disappeared. The prognosis essentially depends on the course. The more frequently the chills are repeated, the more rapidly strength is lost; the earlier the symptoms of internal metastases present themselves, the sooner the patient will die. The longer the intermissions between the exacerbations of fever, the better the strength is preserved ; the longer the tongue remains moist, the more hope we have of the patient's recovery ; he is not out of immediate danger till the wound again looks well, till he has been entirely free from fever for several days, and has otherwise the ap- pearance of a convalescent. It is exceedingly rare for a patient who presents all the above symptoms of decided pyaemia to recover. We must now go somewhat deeper into the etiology of traumatic infectious fever. At present there is probably no doubt that it is usually due to reabsorption of putrid fluid or pus ; that it is alicays so, is indeed disputed. Many surgeons assert that pyaemia very fre- quently results from miasma, especially from a miasma which develops from the wounds of many patients lying together ; this view is based chiefly on the fact that where many severe surgical cases lie together (as in large hospitals, especially army hospitals), many of them die of pyaemia, and that even mild cases, patients with cicatrizing granula- ting wounds, become pyemic under such circumstances. This is no place for polemics, hence I must be content with giving you my own views on the subject. I can entirely agree to the miasmatic origin of pyaemia, if by miasma is understood what I understand by it in the present and some other cases, namely dust-like, dried constituents of pus, and possibly also accompanying minute, living, very small or- ganisms, which in badly- ventilated sick-rooms are suspended in the air or adhere to the walls, bedclothes, dressings, or carelessly-cleaned instruments. These bodies, which are in some respects of different nature, are usually phlogogenous, all pyrogenous, when they enter the blood ; of course they will collect chiefly where there is the best oppor- tunity for their development and attachment, that is, in badly-venti- lated sick-rooms, where the patients are carelessly attended, where there is deficient cleanliness, and the patients remain some time in the same apartments. It is impossible to say whether all pus, moist or dry, is alike injurious ; experiments on animals give us no information on this point. It is only within the last ten years that the distinc- tion between pyaemia and septicaemia has been accurately made ; it is based on etiological, clinical, and anatomical grounds, as I have 382 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. described. Now, objections are made to this distinction ; it is as- serted that the poison is the same in traumatic fever, septicaemia, and pyaemia, and that all are due to the growth of cocci. I can assure you, we know nothing certain about it ; possibly it is true, perhaps not. But the clinical appearance of these diseases gener- ally differs enough to separate them till we know more about them ; if it should be shown that the difference is due merely to more or less intense action of the same chemical process, it would be a beau- tiful scientific discovery, but would not detract from the clinical and prognostic value of the descriptions. From my own experience I can say that there are cases answering to those for which Sueter proposes the name " septo-pyaemia," where the symptoms of septi- caemia and pyaemia are mingled. The term " subacute pyaemia," used by Stromeyer and other older colleagues, corresponds to our septicaemia. What the French call " gangrene traumatique foudroy- ante " is a rapid decomposition and turning green of tissue, with great development of gas deep in the muscles, during the life of the patient. It is very rare ; I have seen two such cases after amputa- tions at the thigh for severe injuries. I consider the idea of animated, dust-like miasma a very fruitful one, and if in any of you it calls to life new thoughts, which lead to actual studies, the chief aim of my exertions as teacher is gained. The old doctrine of the gaseous form of miasmata has always led us into deep water ; many shrewd per- sons have exhausted their brains on this point, without advancing it much. Another common question is, Is pymmia contagious f Ac- cording to the view I have just given of pyaemic miasm, this is an- swered to some extent both in the affirmative and negative. A fixed molecular miasm, originating from a suppurating pyaemic patient, must at the same time be regarded as a fixed contagion ; but accord- ing to my view this miasm may just as well come from a non-j)yaemic patient ; then it cannot be termed contagious in a specific sense, for a contagion always induces the same disease. You see that the strife as to the contagiousness or non-contagiousness of pyaemia must go back to the views as to the nature of the disease ; it is only impor- tant for those surgeons who regard pyaemia as a peculiar specific dis- ease, not related to suppurative fever — a view which I regard as groundless and practically useless, and against which I have long- fought, and I hope with some success. With all these things arises the question, Does pywmic miasm enter the body only through the wound, or also through the shin and mucous membranes f Although the latter is not impossible, I have not yet made any certain obser- vations by which such an hypothesis can be considered proved or even probable ; but from my experience I hold to the opinion that PYEMIA. 383 the infection of the whole body comes from the wound, whether the poison finds circumstances favorable to its development in the wound and surrounding parts, or whether it be introduced into the wound already developed. I am not shaken in this view even by those rare cases where there is no visible change, or only very little, in the wound on commencing pyaemia, for possibly the infecting body has very little if any phlogogenous action, and hence may enter the blood through the wound, and have a pyrogenous action, without causing any change in the wound at its entrance. Sex seems to have very little influence on the frequency of infectious diseases of this class ; possibly tempera- ment, the energy and frequency of the contractions of the heart and arteries, may have more influence on the reabsorption of the delete- rious substances. Judging from general impressions, children seem less disposed to pyaemia than adults. It would be exceedingly diffi- cult to make statistics on this point, as so few severe injuries occur in women and children as compared with men ; consequently, the fact that so many more men die of traumatic-infection fever of course proves nothing about the predisposition of either class to this disease. Open wounds of bone particularly dispose to pyaemia ; judging from my experience, those wounded in the lower extremity are most, those wounded in the trunk are least, in danger of becoming pyaemia The time of year and the collection of severely wounded in hospitals seem to have little if any direct influence on the development of py- aemia, unless by causing greater accumulation of infecting matter in the dressings, etc., thus increasing opportunity for infection. Lastly, I must mention the so-called spontaneous pyaemia. Cases occur where multiple abscesses (of the subcutaneous tissue, for in- stance), or even venous thrombi with embolic metastatic abscesses, ap- pear without our being able certainly to detect any primary point of suppuration ; these cases, especially if they run an acute course, are called spontaneous pyaemia. There is no reason for raising a new theory for these rare cases, where we simply fail to detect the primary point of inflammation ; I doubt not that there will hereafter be less mention of these cases, which, according to old theories, were very enigmatical, as we are constantly learning to observe more accurately, and, on more careful examination, shall usually find the connection of the symptoms. From the intimate relation, which we suppose to exist, between traumatic fever, septicaemia, and pyaemia, it seems correct to speak of the treatment of these diseases under the same head. This may be divided into prophylaxis, and the treatment of the developed dis- ease. The former is by far the most important ; it consists in avoid 384 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. mg every thing that may favor the disease. Even in operations there are some points to be observed ; all the instruments used, the hands of the operator and his assistants, and the sponges (which should either be perfectly new or should be replaced by moist compresses), should be perfectly clean ; haemorrhages should be entirely arrested, especially if sutures are to be applied, and the wound is deep ; if the wound heals by suppuration, the compresses should be moistened with chlorine-water. In accidental injuries, all deep wounds, particularly if contused, should be kept quiet by dressings ; all that is necessary in compound fractures has already been said. Every thing that can excite secondary inflammation (page 165) should be most carefully avoided ; the patient should lie quiet, and as comfortably as possible. I would remind you of the treatment, previously given for contused wounds. Of course the greatest care must be used in dressing the wound ; here the greatest pedantry may be very beneficial. Hospital influences, which I only touch on here, are peculiarly interesting. Although few of you may have the fortune to control civil hospitals, any of you may desire knowledge on this point during war. Of course, hospitals should only be located where there is no marsh miasm. The hospital should be placed in a large, open space, with trees planted about it, and should have properly-located odorless wa- ter-closets. Of all artificial systems of ventilation, I think that Van HeTce's is the only one worth any thing. In it the walls of the whole building are traversed by canals, opening into every ward. All these canals start from cross-passages under the building, at whose points of intersection there is a sort of wind-mill, driven by steam, so that new air is thus constantly driven into the wards of the hospital (pul- sionssystem). If there be no artificial system of ventilation, we must do as well as we can with the so-called natural ventilation, i. e., cor- responding draught-openings should be made above and below in doors and windows, so that in their beds the patients may escape the draught as much as possible ; these ventilators should never be en- tirely closed. An excellent English surgeon, Spencer Wells, says : " There is only one true means of ventilation : the impossibility of closing doors and windows." I consider a proper use of the wards as important as their ventilation. No surgical ward should be used more than four weeks in succession ; it should then be emptied for a few days and carefully cleaned ; the walls should be painted with oil- paint so that they may be washed, or else they should be white- washed at least two or three times a year, more frequently if neces- sary. The beds should be frequently aired, shaken up, and sunned, and the straw in the sacks often renewed. Every surgical division should have one, or, still better, two supernumerary wards, so that TREATMENT OF TRAUMATIC FEVER, ETC. 385 they may be regularly occupied in turns. With the same object, there should not be more than six or eight beds in one ward, so that enough patients may be discharged every week to empty one room. The new patients should always be brought into the ward last cleaned. This is the only way to prevent the extensive development of miasm in hospital. To attain the best possible results in hospital we must have plenty of room, and plenty of money for nurses, linen, etc. We can thus use even badly -located hospitals. Large wards, with twenty or thirty beds, which, from press of patients and other causes, cannot be emptied at will, are very unsuitable. The director of a surgical division should, above all things, have at his disposal a large number of well-ventilated rooms of medium size, which can be emptied and cleaned at certain times. Bad hospitals, and especially badly-kept rooms for surgical patients, are worse than the poorest tenements ; they may become slaughter-pens for the wounded. Sur- geons should never forget that they themselves are often to blame if their patients have erysipelas, hospital gangrene, diphtheria, etc. ; for, if, after old customs, we ascribed every thing to the invisible, omni- present, intangible, ethereal miasm and genus epidemicus, it would be death to all our future progress. Coming now to the treatment of traumatic fever, septicaemia, and pyaemia, we may say that, for simple traumatic and suppurative fever, which does not pass the usual limits, we generally use nothing but cooling drinks, fever diet, and a little morphine at night to secure good rest. If the fever lasts longer, or assumes a peculiar character, we may resort to febrifuges. Digitalis is here of little use, on account of its slow, uncertain action. Veratria reduces the temperature, but appears to do little good in toxic traumatic fevers ; still, further obser- vations must be made on this point, especially in pyaemia. The ac- curate studies of JBiermer show that this remedy should be used very carefully. Formerly aconite was highly recommended in pyaemia by Text or. I have seen no good from it. Quinine is the most effica- cious remedy for the intermittent suppurative fever, especially in com- bination with opium ; 6-8-16 grains of quinine in the course of the afternoon, and one grain of opium at night, often arrest the chills ; in severe suppurative fevers I employ these remedies with benefit ; in decided pyaemia they do less good. After careful observation, Lieber- meister found that quinine only showed its antifebrile action in typhus and other infectious diseases with certainty when given to the extent of fifteen grains or more daily. There are plenty of observations, too, on remedies for directly opposing the blood-poisoning. I have found no effect from the antiseptic internal remedies, the acids, chlorine-wa- ter, and sulphurets of the alkalies (which are greatly praised bv Polli). 25 386 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. But we may also use other remedies, intended, by increasing the change of tissue, to separate the organic poison from the blood. See- ing the profuse diarrhoea in dogs artificially made septicaemic, and finding them to recover frequently after these diarrhoeas, we might suppose the poison to be most naturally excreted through the intes- tinal canal. In fact, Breslau has had favorable results from repeated doses of laxatives in puerperal fever. I am sorry not to have had similar experience in pyaemia. In this disease diarrhoea is a severe complication, which quickly induces collapse. It might also be thought advisable to increase the secretory activity by giving emet- ics ; but they are followed by such collapse that we must be careful in their administration. In septicaemia I have often tried to induce profuse perspiration, when the skin was very dry. This was occasion- ally done by a warm bath, lasting for an hour, and then wrapping in blankets. This occasionally does good ; indeed, I think patients have thus been saved that I had thought incurable. Further trials should be made with this remedy. Copious diuresis also may be induced by plenty of drink, but it has not much effect on the general condition. Lastly, we might think of arresting the further absorption of inju- rious substances from the injured or inflamed part by amputation, even after the appearance of severe constitutional symptoms. In acute cases of septicaemia and pyaemia this very rarely has a perma- nently beneficial effect, although there is almost always temporary improvement. But in subacute and chronic pyaemia amputation may, indeed, save life ; unfortunately, however, such cases are rare. So we finally come back to what we said at first, that much may be done to prevent severe traumatic and suppurative fever, but that there is little to be hoped from treatment of these diseases when fully developed. 22 LECTURE XXVII. 4. Tetanus; 5. Delirium Potatorum Traumaticum; 6. Delirium Nervosum and Mania. — Appendix to Chapter XIII. — Poisoned Wounds ; Insect-bites, Snake-bites ; Infec- tion from dissecting Wounds. — Glanders. — Carbuncle. — Hydrophobia. The group of diseases which belong to the traumatic and phlogistic infectious conditions, and of which we still have to speak, comprises tetanus, drunkard's madness, and the psychical disturbances which so rarely occur after injuries and operations. The views, as to their ori- gin, vary greatly ; as, from their symptoms, the processes in question would be referred to irritation of the brain and spinal cord, their cause TETANUS, 387 is usually sought m the nervous centres. But it is known that by blood-poisoning, with strychnine, severe spasms, and with alcohol, psychical disturbances (drunkenness) may be induced ; hence, it is very possible that the following forms of disease may result from poisoning with peculiar substances, which possibly are very rarely formed in wounds, and thence absorbed, while in drunkard's mania a series of ordinary pyrogenous materials may excite certain disturb- ances (namely, fever with peculiar, predominant psychical disturbances) in the organism already poisoned by alcohol. The symptoms that we shall see in these diseases are all present in ordinary fever, although to a slighter and less prominent degree ; in the combination of the affected muscles, chills have an undoubted similarity to tetanus, psy- chical disturbances, even to maniacal attacks, occur as so-called fever delirium in some cases of septicaemia, but especially in typhus. In de- scribing the individual diseases, we shall occasionally recur to these remarks, for which, unfortunately, we have no experimental foundation. 4. Traumatic Tetanus [Trismus). — This disease, which consists in spasms of the muscles of the jaw alone (trismus), or of all the muscles of the body (tetanus), the muscles of the extremities being most affected sometimes, at others those of the front or back of the trunk, occasion- ally occurs in the wounded ; though it is rare in proportion to the traumatic diseases above described, it occurs still more rarely in per- sons without wounds. In large hospitals, years may pass without a case of tetanus being seen ; again, at certain times, numbers of cases will appear, so that there has been an inclination to seek an epidemic cause. The disease is by no means confined to hospitals, but comes either in or out of them. However, before discussing the etiology, I will try to give you a brief description of an acute case. The third or fourth day after an injury, rarely sooner, often later, you find that the patient cannot open his mouth well when speaking, and complains of tearing, drawing pains, and of stiffness in the masti- catory muscles. In very acute cases there is high fever even with these first symptoms, in other cases the patient is free from fever at this stage. The lines in the patient's face gradually assume a pecu- liar, stiff expression, the facial muscles being to some extent spasmod- ically contracted. Subsequently there are tetanic spasms, which may affect the trunk or extremities ; in some cases these last several sec- onds or minutes, and are induced by any external irritation, just as in hydrophobia. These spasms are accompanied by severe pain. Occa- sionally, from first to last, some groups of muscles remain regularly but painlessly contracted; in some patients the twitchings (shocks of Hose) are entirely absent, and there is only permanent contraction of more or less distinct groups of muscles. Not unfrequently the 388 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. patient's body is bathed in sweat, his mind being clear ; occasionally the urine contains albumen ; sometimes the fever rises to a height that is rarely seen, even to 104° Fahr., or over. But I have seen cases of trismus prove rapidly fatal, without the temperature becoming ele- vated ; Rose has made similar observations. Death may occur within twenty-four hours from the commencement of the disease, but the lat- ter may also last with considerable severity for three or four days ; these cases also are to be classed among the acute. There is a more subacute or chronic form of trismus, and of trismus and tetanus, in which there is merely a gradual development of a moderate trismus and of contractions without pain, extending to single groups of mus- cles of the injured limb. In these chronic cases fever is usually en- tirely absent. It is rare for an acute case to become chronic. All the symptoms indicate that there is an irritation of the spinal medulla and of the portio minor of the fifth pair. The symptoms re- semble, although remotely, those which may be induced by poisoning by strychnia. Unfortunately, the results given by autopsy of these patients are usually very unsatisfactory ; in the acute cases, especially, nothing can be found in the spinal medulla ; in cases of some days' duration, Rokitansky claims to have seen a development of young connective tissue in the spinal medulla, which would make it appear that there was an inflammatory aifection of this nerve-centre. My ex- aminations of the spine and nerves in tetanus have thus far given only negative results. In preparations made from cross-sections of the spinal medulla, and sent to me by excellent specialists in examining the nervous system (Dr. Gott, in Zurich, and Dr. Meynert, in Vienna), I saw the connective tissue remarkably developed at some places, it is true ; but, as there was no collection of young cells, I was in doubt whether this increase of connective tissue was really new formation, or was due to mere accidental swelling. The symptoms during life, in cases where we find decided evidences of spinal inflammation, are so different from tetanus as to render it improbable that the latter de- pends on myelitis spinalis. The discovery of small extravasations of blood in the muscles and nerve-sheaths, on autopsy, shows little about the nature of the disease, for they may be caused by ruptures of the capillaries during the great muscular contractions. There are many views as to the causes of this disease, as there usually are about affections with no anatomical, pathological charac- teristics. At first, it was natural to examine the nerves, and in many eases the nerve-trunks are crushed by the injury, or torn or irritated by foreign bodies. I myself have seen some such cases ; a few years since, I saw a sporadic case where, in an open splintered fracture of the lower end of the radius, the median nerve was half torn through ; the TETANUS. 389 third day trismus and tetanus appeared suddenly, and proved fatal in eighteen hours. It is no use to build theories as to how this particu- lar variety of injury of the nerves should induce tetanic spasms, whilf they are very rare after simple division of the nerves, for there are many cases where tetanus has arisen from simple wounds of the skin, from granulating surfaces fully developed and cicatrizing, or even after a blister, the sting of a bee, etc. It is, however, remarkable that the disease is particularly frequent after injuries of the extremities, especially of the hands and feet, while it is rare after considerable injuries higher up the limb and on the body. I also think that I have found the cases, where tetanus developed from granulating wounds, tc be more chronic and milder than those where it has developed soon after the injury. Hose thinks that tetanus appears particularly in cases that are treated badly or not at all ; my experience is opposed to this. After applying in vain to the nerves and tendinous tissue, the various changes of temperature were resorted to to explain the occurrence of tetanus ; some said that it was favored by hot, sultry weather. I cannot altogether deny this view, for hitherto I have only seen numerous cases of traumatic tetanus in hot, sultry weather, but small epidemics of it have been seen in winter. Others ascribe the chief blame to catching cold from draughts or to rapid changes of tem- perature. Finally, there are still others who do not believe that the nervous system is primarily affected, but think that the blood first becomes diseased and acts secondarily on the nervous system. Within a short time Hose has resurrected an old idea, that tetanus, like hydro- phobia, is to be regarded as a primary blood-disease. It cannot be denied that the two diseases are much alike ; a proof of their being actually analogous would be most strikingly given by inducing hydro- phobia, by inoculating animals with the blood or secretions from a tetanus patient. Of course, we should not think of inoculating another man. At present, I strongly incline to the humoral view of tetanus as due to a peculiar poison, although I have no proofs of it. At all events, the blood of a tetanus patient should be injected into a dog, to show whether tetanus may be transferred through human blood to a dog, and also whether it has a pyrogenous action ; should tetanus appear in the dog, it might be regarded as proved that tetanus was a humoral disease ; if the experiment be negative, it proves nothing against the humoral causes of tetanus, it only shows that the blood of a man with tetanus will not induce tetanus in a dog • it would still have to be decided whether the blood of a dog with tetanus, trans- ferred to another dog, would prove as inactive. The fact that tetanus may be confined to one limb, or even to one hand as I have seen it, speaks in favor of a local cause, which may be limited to the nerves ; 390 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. but there are also a localized lymphangitis, localized erysipelas, etc. ; the fact that, after amputation, for instance, twitching not unfrequently occurs in the stump before the spasms become general, might also indicate that the tetanus-poison formed in the wound first irritated the muscles and nerves of the stump, and then passed to the spinal medulla. There still remains much to be investigated on this point. The high fever in most cases of acute tetanus, and the fact that the temperature rises even after their death, has greatly occupied pathol- ogists ; this became still more interesting when Leyden showed that great elevation of the temperature of the blood was caused in a dog in which tetanus had been artificially induced by passing a strong current of electricity through the whole spinal medulla. A. Fick showed that a surplus of heat was formed in the muscles, and thence distributed to the blood ; also that the elevation of temperature, noticed in the rectum after death, was due to the equalization of warmth between the muscles and the rest of the body. If these experiments, which I have repeated, prove that tetanic muscular contractions con- siderably elevate the bodily temperature, they do not show that in traumatic tetanus in man the high temperature is solely or chiefly due to the muscular contractions ; this view is opposed by the fact that very acute cases of tetanus may run their course almost without fever, although this rarely happens ; here, too, there are many enigmas to solve. Unfortunately, in most cases the prognosis is bad ; very few of the acute cases recover ; of the chronic cases, which last over a fort- night, some get well. Unfortunately, the latter are proportionately rare. From the lack of knowledge about the etiology of this disease, the treatment can be only symptomatic. Numerous remedies have been recommended at various times. Generally, the treatment most resorted to is by narcotics, with opium and chloroform ; this is the plan I have adopted. Opium is given in large doses, as high as fifteen grains or more in a day, or a corresponding quantity of morphine may be given, best by subcutaneous injection ; sometimes this arrests the spasms, sometimes it does no good. At all events, the sufferings of the pa- tient are lessened. During the attacks the patient may be greatly relieved by inhaling chloroform to narcotism. Under this treatment many cases have recovered. The general aim of the treatment is to alleviate the acute course, and make it more chronic, as this gives more hope of recovery. Among other modes of treatment, I may mention the frequent employment of warm potash-baths ; and the application of strong irritants along the spine, large blisters, moxae. the hot-iron, remedies from which I cannot promise any good effects , DELIRIUM TREMENS. 391 and, lastly, the curare, which is of late occasionally used, has not answered the hopes that some had of it. In the chronic cases you need not employ any special treatment ; the patient remains in bed, and should keep perfectly quiet ; he should be guarded against all injurious influences, especially from physical or mental excitement. 5. Drunkard?* madness. Delirium potatorum traumaticum. Delirium tremens. — We now come to an enemy of the wounded which, fortunately, is not very dangerous. You have doubtless heard of delirium tremens, the acute outbreak of chronic alcoholic poisoning, which may come on spontaneously, or from some acute diseases, es- pecially pneumonia. Injuries are a frequent cause. You will become better acquainted with this disease from the lectures on medicine ; as the attacks, from whatever cause they arise, are much alike, I shall be very brief on this point. The disease generally breaks out within two days after the injury, in some rare cases it is longer. It only attacks patients who have for years been accustomed to the free use of alcohol, especially of schnaps and rum ; but it is an error to consider beer and wine drinkers exempt from delirium. The first symptoms are sleeplessness, great restless- ness, trembling hands, unsteady look, tossing about in bed, and talka- tiveness, and then delirium. The patients talk constantly, see small animals, midges, flies, etc., swarming about them ; mice, rats, mar- tins, foxes, etc., crawl from under their beds ; they think they are in a smoky atmosphere, and feel dizzy. The delirium often has the most comical form ; a soldier, whom I treated in Zurich for delirium tremens, saw numbers of other soldiers in his water-glass ; when I entered the room, he spoke lowly to my assistant, taking me for his major, etc. Generally the hallucinations are of a happy nature, never- theless, the patients are tormented with restlessness, constantly toss about in bed, and wish to get up. If we have not two stout nurses to hold these patients, there is often no way of avoiding the applica- tion of a strait-jacket and tying them in bed. These patients are usually good-natured in their delirium, and if spoken to emphatically they give sensible answers, but soon fall back into their wanderings. Of all kinds of injuries, fractures, especially open fractures, most fre- quently give rise to the outbreak of the disease, and, before we had firm dressings for such patients, it was a difficult task to fix the broken limb, as the patients did not notice the pain, and moved the limb so forcibly that any splints were loosened in a few hours. Even where there is marked delirium, the prognosis is not unfavorable, according to most surgeons ; from my somewhat meagre observations, I cannot agree in this opinion : of the patients with acute delirium tremens that 392 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. 1 have treated, at least the half have died ; they often declined suddenly, became unconscious, and soon died. Others recovered, especially when it was possible to make them sleep a while ; this is the object of the treatment ; opium in large doses is the almost universal remedy, for it we may substitute small doses of tartar-emetic. After this the patients fall into a comatose state, from which in favorable cases they awake cured, but sometimes sleep on till death. I can recommend no better remedy than opium in delirium tremens, although I must ac- knowledge that in large doses (gr. ii. — vi. every two hours till sleep is induced), I do not consider it free from danger [of late, hydrate of chloral, in doses of gr. xx. — 3 i, is said to have been given with great benefit in such cases ; it is claimed that it acts well not only on the delirium tremens, but on the fever which so often accompanies the in- jury]. Of late, there has been a great outcry in England against the opium and tartar-emetic treatment, and a more expectant treatment has been recommended. Others have had good results from digitalis ; most surgeons are well satisfied with the opium-treatment, and the coincident administration of strong wine and cognac has been highly recommended. The more chronic cases of delirium potatorum, with- out maniacal attacks, have seemed to me of more favorable prognosis ; there, strong grog is useful ; I give the following mixture : one yolk of egg, one ounce of arrack, four ounces of water, two ounces of sugar ; this does not taste badly, and may also be used as a stimulant for old persons (a tablespoonful every two hours). I must warn you against abstracting blood, which is very dangerous in drunkards, and not un- frequently induces collapse terminating in death. Autopsy of patients who have died of delirium tremens shows no special cause of death ; we find the changes common to topers ; chronic gastric catarrh, fatty liver, Bright's kidneys, thickening of the meninges of the brain, but no constant changes in the brain-substance proper. 6. Delirium nervosum and psychical disturbances after injury. — By delirium nervosum traumaticum we mean a state of excessive nervous exaltation without fever, occurring after injury ; this is said particularly to affect hysterical persons. I have only seen one case to which I could apply this name : a man twenty-four years old (from Canton Thurgau, the land of perry), who had never been accustomed to drinking, after a fracture of the leg, complicated with a slight wound, soon had delirium without fever, like an old toper ; the fan- cies referred to the same subjects as in delirium potatorum, passed off under quieting treatment and opium, without maniacal attacks ; after four days the delirium ceased, and the patient remained reason* able. Lastly, T must mention those rare and interesting cases where, POISONED WOUNDS. 393 after operations in otherwise healthy persons, psychical disturbances develop, cases which evade all attempts at explanation, and are only analogous to cases where, after acute diseases, such as pneumonia, acute rheumatism, or typhus, the development of true mania is ob- served. In the Berlin surgical clinic I saw tw^o such cases, in both of which, after total rhinoplasty, there was melancholy with religious hallucinations. Both patients were Catholic : one, a young man, in- cessantly worried himself trying to understand the idea of the TrinhVy ; the other patient, a young woman, sought by prayers and castigations to atone for giving way to her vanity so far as to have a new nose made to replace the one lost by lupus. In the young man there were frequent outbursts of rage ; both patients perfectly recovered after a few weeks. I have heard that Von Langenbeck, in Berlin, had an- other such case after a plastic operation, and Von Grclfe and JEs- march have had them after operations on the eyes. But these cases are very rare. APPENDIX TO CHAPTER XIII. POISONED WOUNDS. We have still to treat of some varieties ot injuries, where at the time of the injury poison is inoculated, which sometimes induces severe local symptoms, sometimes dangerous general disease. It is well known that these poisons are peculiar to some animals, and in others they develop as a result of certain diseases, and are then trans- ferred by the diseased animal to man. The results from punctures of a large number of small insects are scarcely in proportion to the slight mechanical irritation caused by their stings; it may, it is true, depend partly on peculiar susceptibility of the skin, if persons have extensive temporary inflammations of the skin after bites by bugs, midges, or fleas, while others are not affected by them. A needle-puncture is a much greater injury than a flea-bite, but the latter is followed by itching and burning, and the formation of wheals on the skin, while the results of the former amount to nothing. Hence it is not improbable that in the case of the wound made by the insect some irritating substance enters the skin. As is known, the stings of bees and wasps excite even greater disturbances ; occasionally there is an extensive, very painful inflammation of the skin, with great red- ness and swelling, which usually terminates in resolution, and does not prove dangerous, but may be very annoying. A large number of such stings at the same time is not altogether free from danger ; such 394 TKAUMATIO AND INFLAMMATORY DISEASES, ETC. stings on the tongue, in the palate, or on the eyelids, may from their locality cause certain dangers by the swelling induced. But, as these inflammations subside in a relatively short time, a physician is rarely called ; the popular treatment is by various cooling remedies to allevi- ate the pain, among which I shall merely mention the application of moist clay, raw mashed potato, cabbage-leaves, etc. In more severe inflammations, lotions of lead-water and other antiphlogistic remedies may be resorted to. Still more severe than the stings of bees and wasps are those from tarantula? and scorpions, that are seen in southern countries. They are followed by more extensive inflammation of the skin, with severe burning pains, occasionally by formation of vesicles ; there may also be fever, but there is usually no danger, unless it arise from the locality of the injury. The treatment should be that above given. Fortunately, with us there are few varieties of poisonous serpents, and even they are not frequent. Among them are the "Vvpetra JSerus (cross adder), and Viper a Hedii, with two hook-like, curved fangs, containing the excretory ducts of small glands, which, at the time of the bite, pour their poison into the wound. The bite of these ser- pents is not so dangerous as is supposed; according to statistics, about two die out of sixty persons bitten. The pain is very severe ; there are great inflammation, tension and swelling of the skin, with high fever, great anxiety, depression, vomiting, and occasionally slight icterus. The best treatment is to suck out the wound at once, as the poison is not absorbed by the gastric or oral mucous membrane. The wound should be washed at once, and it is advised to ligate the injured limb above the wound to prevent the absorption of the poison ; but this has usually taken place by the time the patient reaches the surgeon ; it is a disputed point whether the application of cups, the cauterization, burning or excision of the wound, be now of any ser- vice, but I should think its cauterization advisable. The local cutane- ous inflammation is treated with special attention to the intense pain ; by applications of oil, protecting the skin from the air by various rem- edies, with which we become acquainted in the treatment of superfi- cial burns. Internally we usually give an emetic, then antiseptic remedies. Of all snake-bites in southern countries, those of the rattle- snake are most dangerous ; sometimes they prove fatal in a few hours ; the local inflammation of the skin, which is very severe and extensive, not unfrequently ends in gangrene ; those bitten die with high fever, delirium, and sopor. [Prof. Halford, of Australia, treats snake-bites by injecting diluted liquor ammonias into the veins. See London Medical Times and Gazette, 1869, page 123.] Cadaveric poison is a very phlogogenous substance, which proba- bly varies greatly in its chemical composition. Some of you may have POISOXED WOUNDS. 395 already had some experience on this point, in the dissecting-rooms. This putrid poison develops in the corpses of men and animals; if, in handling these, some of the juice from the dead tissue enters small, insignificant, and scarcely noticeable injuries of the skin, very dis- agreeable symptoms may develop. The resulting conditions are vari- ous, sometimes very malignant. Cases occur which were formerly seen particularly often in England, where at first there is little pain in the wound, but there are great depression, headache, fever, and nausea ; then come delirium and sopor, and in some cases death takes place in forty hours. It is asserted that these worst cases of septicaemia were most frequent, from autopsies made soon after death, on bodies still warm, and it was doubtful if in these cases the surgeon had not inoc- ulated himself with morbid matter developed in the body while still living, for the state usually termed putrefaction could not have begun. As a contrast to this malignant acute form, we may regard those cases where the poison has a purely local action. In the course of twenty- four hours there are moderate pain and slight induration in the injured finger; then a dry scab forms on the wound; under it there is always some pus. The scab forms as often as it is removed, the part remains painful and hard ; in the course of time the epidermis thickens over it, and it forms a painful, wart-like nodule, moist on the surface. One in- clined to this purely local development is usually less disposed to general infection. Between these two forms stands a third, where an inflammation of the lymphatic vessels and axillary glands accompanies the local inflammation ; under early treatment this may end in resolu- tion, but it often leads to abscesses in the arm. For the first treatment of the part poisoned by cadaveric matter, I advise you to let cold water run on the wound for a long time, and not to check the bleeding, if there be any. In many cases the injurious matter will be at once washed out, and there will be no further infec- tion. Should the parts around the wound redden, you may cauterize with nitrate of silver or fuming nitric acid ; this is very painful, but it acts well ; not unfrequently pus forms again under the resulting slough ; in this case you remove the slough, and cauterize again, and repeat this till no pus forms under the slough. Cauterization immediately after contact with the poison, from a considerable experience on myself and on my students in the course on operations, I consider unadvisable. Small, lacerated wounds that do not bleed, and excoriations, are always more dangerous for infec- tion than deeper incised wounds ; the anatomical reason for this is that the lymphatic net-work lies chiefly in the most superficial layer of the cutis. Moreover, the susceptibility to the poison varies with the individual ; repeated infections appear rather to increase than to 396 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. diminish the predisposition. Should lymphangitis begin, the arm should first of all be placed on a splint to keep it quiet, and then the treatment previously recommended for lymphangitis instituted. You may consider the course in the appearance of the above morbid symp- toms to be as follows : A small quantity of liquid from the cadaver (or even of putrid pus from a living patient) is introduced into the wound ; the lymphatic capillaries that have been opened take up this putrid matter and pass it into the trunks of the lymphatic vessels ; coagulation may quickly take place here, and then the putrid matter acts as a specific irritant only on a small part ; in other cases it acts on the lymph as a ferment, and the lymph coagulates in the next lymphatic glands, or else the swelling of the gland compresses the intra-glandular lymphatic vessels and so obstructs the passage through the gland ; in this case also the disease remains local, al- though extending some distance, and not unfrequently leading to suppuration with fever (as in other non-specific inflammations). Lastly, the rarest cases : the fermented lymph, which even yet acts as a ferment, passes into the blood, and there excites chemical changes. Then we have a septicaemia, from cadaveric poison. From the cases that end in recovery we see that the injurious substances developed by the process may be again eliminated from the body by the secretions and excretions, but we do not know in what particu- lar way this is done. In some cases some putrid substance is encap- sulated in a lymphatic gland or other inflamed part, and may there lie harmless and after a time be gradually eliminated ; but on active movement the poison may be again driven into the lymphatic vessels by the increased pressure of the blood, and there induce new, acute, local, and general infection. If indurated lymphatic glands remain after infection with cadaveric poison, daily warm baths are the best means for promoting the excretion of the poison. We have still to treat of some poisons which in certain diseases develop in animals, and may thence be transferred to man. Under this head come glanders, carbuncle, and hydrophobia. Glanders (maliasmus, morve) is a disease which develops prima- rily in horses and asses. It is an inflammation of the nasal mucous membrane, in which this membrane becomes very thick, and secretes a thick, tough pus, and where, by the breaking down of caseous nod- ules, ulcers with a caseous base form ; swellings of the lymphatic glands, occasionally tubercle-like nodules in the lungs, and acute ma- rasmus, occur, and acute cases are usually fatal. The more chronic and milder form of glanders is called " farcy ; " it is rarer, and gives a CARBUNCLE. 397 better prognosis. The glanders and farcy of animals are only con- veyed to man by accidental inoculation. If some of the pus of a glan- dered horse enters a wound or excoriated spot on a man, or if very in- tense poisonous glander-pus fall on the uninjured skin at a point where the epidermis is thin, there may be very acute inflammation with gen- eral septicaemia, which in most cases proves fatal. The chronic form of glanders is rare in man ; the symptoms are chiefly pustulous inflam- mations of the skin, and formation of abscesses at different points in the subcutaneous tissue ; it is not so dangerous. In some cases of acute glander-poisoning there is lymphangitis and suppuration, limited to the injured extremity ; in others a diffuse erysipelatous redness of the skin with great swelling develops quickly, while at the same time there is very intense fever. The local inflammation may go on to gangrene ; there is delirium, and soon coma occurs ; there may also be diarrhoea, purulent discharge from the nose, and pain in the muscles, with which symptoms the patient dies. The disease may run its course very rapidly ; I remember, when a student in the Got- tingen clinic, seeing a strong, robust man die of glanders in a few days ; but patients with acute glanders may live from ten to fourteen days, and all the symptoms of pyaemia may develop in them, and nu- merous haemorrhagic abscesses form in the muscles, which are so characteristic of glanders that they confirm the diagnosis. In rare cases acute, rapidly-fatal glanders may develop from the chronic; the reverse is also seen. Of course, persons that have much to do with horses are chiefly exposed to this disease, which never occurs primarily in man. Unfortunately, there is little hope from treatment in this disease ; as in acute pyaemia, we treat the most prominent symptoms. Iodine, arsenic, and creosote, have been recommended as antidotes in glanders. Carbuncle (anthrax, pustula maligna) is an infectious disease oc- curring primarily most often in cattle. It is called in German " Milzbrand " (gangrene of spleen), because in animals that have died of it the spleen is found greatly swollen, dark red, and gangre- nous ; in many cases also the intestinal mucous membrane is bloody- red and swollen ; the loose subperitoneal cellular tissue, and occa- sionally the subcutaneous cellular tissue, of one of the limbs is often the seat of brawny infiltration ; in the intestinal mucous membrane, and sometimes in the skin, carbunculous infiltrations may occur. As in all infectious diseases, the course varies in rapidity according to the amount and intensity of the poison absorbed and the resisting powers of the patient ; it may be foudroyante (apoplectiform), or may go on for several days. The herbivora are more readily infected than omnivora or carnivora. The contagion adheres to the products 398 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. of the disease and the patient. Nothing certain is known about the origin ; since it is more frequent in some regions than others, it has been thought that the soil and food had some effect. The intestinal secretions are mixed with the dung of the animals, and their poison- ous effects have been proved. If such dung be spread over the land, and, either fresh or dried on hay, be eaten by other animals, they may be attacked by the disease. Transfer of the affection to man is most often through the matter of the pustule ; if this or the dried skin of the dead animal be brought in contact with the skin of man, even if it is uninjured, the poison may enter through a hair-follicle or sweat-gland ; the result is a pus- tule, at first unnoticed, then itching and burning, in the centre of which a black blood-blister soon forms ; high feYer soon comes on. In bad cases the cutaneous inflammation early assumes the character of carbuncle, terminating quickly in gangrene, and if left to itself the disease is usually fatal. Internally we give the ordinary antiseptics ; the anthrax itself is to be energetically attacked by incision, excision, caustic potash, nitric acid, etc. If the patient comes under treatment early and there is no intense blood-poisoning, there is hope of cure ; if the pus- tule is fully developed and septic symptoms have begun, death is certain. Recent observations show that infection in veterinary sur- geons from post-mortem examinations of diseased animals does not have such a dangerous course, but often gives rise to a phlegmon of medium intensity, which may pass off in a few days with scaling off of the skin. Quite lately Leube and W. Mutter have described cases where severe intestinal inflammation ending fatally followed the use of flesh from animals that had died of carbuncle. According to Zol- linger, the milk of cows with this disease proves infectious to man. It is still a disputed question whether malignant pustule may also develop primarily in man; whether the malignant carbuncle de- scribed in Lecture XXI. always comes from infection, or may come spontaneously from the same causes as in animals. Eminent sur- geons and veterinarians have investigated this subject ; inoculations of secretion from malignant carbuncles of man on animals have proved very uncertain ; observations have been contradictory ; in short, the relation of these different forms of carbuncle and pustules to each other, in regard to their etiology, has not yet been cleared up. Of late the view that the septic poison of carbuncle is associated with certain small organisms is gaining ground. Davai?ie especially holds that the bacteria (first described by Pollender in 1855) quite constantly found in the blood of living animals with carbuncle, or of those that have died of this disease, are the cause of the affection. CARBUNCLE. 399 But we may doubt if it cannot exist without bacteria, as it is asserted that with blood from carbunculous animals, which contains no bac- teria, other animals may be infected. In Leube's cases, already men- tioned, countless cocci and bacteria were found in the intestinal mu- cous membrane (mykosis intestinalis, Buhl). Many assert that the bacteria found in carbuncle differ from those resulting from decompo- sition. Bollinger asserts that small cocci (bacteria germs) exist in the blood of every animal affected with carbuncle, but that from their small size they often escape observation ; he considers their vegetation as the essential cause of the disease, which is, however, favored by the species of the animal, its nourishment, and the char- acter of the soil and stabling. My own observations have shown me that the bacteria of carbuncle, like those in the blood and peri- cardium of decomposing bodies, belong to the meso- and megalo-bac- teria ; and also that cocci and even permanent germs (Dauersporen) often form in them. On inoculating blood containing bacteria in the cornea of rabbits, Frisch saw stellate figures form, evidently com- posed of bacteria, which developed enormously and led to suppura- tion of the eyeball, but never to general infection or the death of the animal. The inoculations of blood from horses and cattle w T hich had shortly before died of carbuncle on rabbits, Guinea-pigs, sheep, and dogs, in the cases I witnessed, proved more certain in proportion to the certainty of the presence of bacteria ; and uncertain results oc- curred, as they did in the cases of other observers. We must also mention the mouth and hoof disease of cattle, as recent observations have proved its transfer to man. In cattle the disease consists in the formation of vesicles and pustules on the mucous membrane of the mouth, at the roots of the hoof, and on the udders of cows ; these heal spontaneously in from five to fourteen days ; and although the animals often emaciate greatly, only the young ones ever die. The disease seems to spread epidemically through the secretion from the pustules, the milk, and perhaps also through an evanescent contagion. The transfer of the affection to man results from contact of abrasions of the skin with the matter from the pustules, or from free use of uncooked milk of the diseased animals. If the latter has been the mode of origin, vesicles and pus- tules form in the mouth and on the hands and feet, as in the cattle. Catarrh of the throat and stomach may be added. The treatment consists in frequently rinsing the mouth, painting the vesicles with solution of borax (five parts to thirty of honey), and touching the pustules on hands and feet with nitrate of silver. Cooking destroys the infecting matter in the milk. It is not improbable that some aphthous diseases of small children arise from infection by milk thus 400 TRAUMATIC AND INFLAMMATORY DISEASES, ETC. diseased. In man the disease runs its course without much danger, as it does in cattle ; only very young, feeble children could be endan- gered by it. [According to Letheby (" Lectures on Food "), " Dr. Livingstone tells us that when the flesh of animals affected with pleuro-pneumonia is eaten in South Africa by either natives or Europeans, it invariably produces malignant carbuncle. He says, indeed, that the effects of this poison were often experienced by the missionaries who had eaten the meat, even when the presence of the disease was scarcely per- ceptible. . . . The virus, he says, is neither destroyed by boiling nor by roasting, and of this fact he had innumerable instances. Now it is a remarkable circumstance that ever since the importation of this disease (pleuro-pneumonia) into England from Holland in 1842, the annual number of deaths from carbuncle, phlegmon, and boils has been gradually increasing."] Canine madness (hydrophobia, lyssa), which is transferred from animals to men, is better known and more frequent than either of the above diseases. From unknown reasons, the disease appears to de- velop primarily only in dogs; but from the bite of this animal, and the entrance of its saliva into the wound, it may be transferred to any animal, and apparently the poison does not decrease by inoculation, but is always propagated with equal power. For instance, a mad dog bites a cat ; the disease develops in the latter, and she bites a man ; an animal being inoculated with the saliva or blood of the man will have the disease. The symptoms in the dog are described by the veterinarians as follows : We distinguish a raving and a quiet madness ; previous to both of them the dog is downcast and eats little. After this state has lasted about a week the raving madness begins; the dog runs about in an objectless, unsteady way, apparently urged by some in- ward anxiety ; if irritated, he bites at any thing coming in his way ; the mouth is dry ; he tries to drink, but soon runs from the water without taking it ; he emaciates, he totters, then his hind-legs become par- alyzed, his barking changes to a kind of howl, twitchings come on, and in three or four days are followed by death. In the still mad- ness, paralysis of the muscles of the lower jaw occurs early, render- ing biting and eating impossible. The other symptoms are the same as just described. Some do not consider these two forms of the disease as distinct, but as different stages, only lasting a longer or shorter time. On autopsy of animals dying from this disease, we usually find the gastric and intestinal mucous membrane much red- dened ; this is probably merely due to the various foreign bodies that the dog has swallowed. Beyond this, we find nothing abnor- HYDROPHOBIA. 401 mal, especially in the brain and spinal medulla; but we must add that hitherto no microscopical examinations of these parts have been made, while it is very probable that, in cases where paralysis very evidently occurs, there is degeneration of the spinal medulla, although otherwise the predominant character of the disease is humoral. As regards the transfer of hydrophobic poison to man, it is a relief to know that all those bitten do not become sick, but that only about one out of twenty cases bitten is attacked. Usually the bite heals readily ; more rarely it suppurates a long time, which is to be regarded as very favorable ; the local reaction is never of such a nature as to' threaten danger, and in this respect the hydrophobic poison differs essentially from the animal poisons heretofore mentioned ; it is not a phlogogenous poison. The outbreak of the disease rarely occurs in less than six weeks after the bite, frequently even later ; a case has recently been observed where the disease first appeared after six months. Older writers give a still longer period of incubation; there is a popular belief that the figure 9 plays an important role y it is said that the disease appears the 9th day, the 9th week, or the 9 th month after the bite, and that before the end of the 9th year there is no security that the disease will not appear. This is certainly a fable, which is readily explained by the fact that the long duration of the incubation is very strange, and has given rise to the various stories. Where the poison remains hidden during this long time, whether in the cicatrix, in the next lymphatic glands, or in the blood, is entirely unknown. In a few cases only it has been observed that, shortly before the outbreak of the disease, the patient had noticed a slight redness of the cicatrix ; then the first symptoms were great irritability, excitement, and restlessness, and in rare cases, even in this stage, there were spasms on attempting to swallow. The irritability con- stantly increases ; the light, every noise or draught, pains these un- fortunate patients, and may excite general spasms and the pains on swallowing. Now, very gradually, the fear of water appears ; the patients suffer from unspeakable thirst, and as soon as they see any liquid they are attacked by horrible anxiety and spasms ; occasionally, attacks of deep spasmodic inspiration follow; the patient cannot sleep, and is in constant dread of the least sound, as any thing excites the convulsions, which finally affect the whole body, and then lead to actual madness, with the appearance of most fearful anxiety. But, on the whole, the patients may be readily calmed by quiet and by speaking to them, and become either perfectly resigned or melancholy. Occasionally they warn those about them not to come too near or they may bite them, but they are not at all malignant, as they were for- merly described. Great salivation and foaming from the mouth do 26 402 TKAUMATIC AND INFLAMMATORY DISEASES, ETC. not begin till toward the end ; in some cases death is preceded by the severest tetanic spasms; others die after the convulsions and the fear of water have completely ceased, and when the patient and surgeon have been led into vain hopes. Unfortunately, pathological anatomy gives us no explanation of this wonderful and fearful disease. There can be no doubt that the spinal medulla is affected, but it has not yet been determined whether the nerve-substance itself is diseased. As regards the prognosis, in those patients where the disease has broken out, there is no hope. It may be considered proper, in all cases, to cauterize or burn out the bites of mad animals, and to keep them suppurating a long time; at least this is the only rational treat- ment. It cannot be certainly decided from past observations whether excision of such a cicatrix can be useful after the disease has already broken out ; it would at all events be a rational treatment. In the developed disease, almost all the powerful remedies in the materia medica and in surgery have been tried ; all the narcotics have been used in large and small doses ; opium and belladonna especially, used in almost poisonous doses, and the artificial benumbing of the patient, have at least alleviated their sufferings, if they have done no other good. The limb containing the cicatrix has been amputated in vain. In one patient, Dieffenbach tried transfusion in vain. Where there is dread of water, some fluid may be introduced through a tube ; the patients are most comfortable when at absolute rest in a half -darkened room ; in combating the convulsions, chloroform narcosis has repeatedly proved most serviceable, and patients who have once become acquainted with this remedy beg for it again. But this comprises the little that we can do for these unfortunates. The three diseases last mentioned enter so much into the domain of veterinary surgery, sanitary regulations, and internal medicine, that I could here give you only a slight sketch of them. You will find more accurate information on the subject in 'Virchow's special pa- thology, Bd. II., Section Zoonosen, where the special literature is also given. In the surgery published by V. Pitha and myself you will also find (vol. i., part ii.) an exhaustive section on the Zoonoses. CHAPTER XIV. CHRONIC INFLAMMATION, ESPECIALLY OF THE SOFT PARTS, LECTURE XXVIII. Anatomy : 1. Thickening, Hypertrophy ; 2. Hypersecretion ; 3. Suppuration, Cold Abscesses, Congestive Abscesses, Fistula, Ulceration. — Eesults of Chronic Inflam- mation. — General Symptomatology. — Course. Gentlemen : Having thus far attended almost exclusively to acute affections, we now come to the chronic, and first of all to chronic in- flammation. In chronic inflammation also, as in acute, there are chemical and morphological changes and nutritive disturbances of tissue ; they are followed by softening and solution, or molecular disintegration, or extensive slowly-developing necrosis of tissue. To these processes are added dilatation of the vessels, exudation, and formation of new tissue. This combination may vary ; chronic inflammation leads to very complicated appearances, according as one or other stage of the pro- cess remains more or less permanent, and according as there is dis- integration, softening, or hardening of the tissue implicated, and as to the varied fate of the inflammatory neoplasia. Etiologieally, the con- ditions in chronic inflammation are much more complicated ; for there it is not merely a question about an irritation only once, as an injury or a burn, and their sequences, but we have, 1, to explain the cause of the inflammation ; and, 2, why it assumes a chronic character. I shall first explain to you what anatomical changes take place in the tissues during chronic inflammation, in doing which, just as we did in acute inflammation, we shall here take the connective- tissue as the ordinary seat of the disease. Besides the distention and multiplication of the capillary vessels by formation of loops in acute inflammation, we found serous and plastic infiltration of the tissue to be the essen- tial anatomical appearances. In chronic inflammation, distention of 404 CHRONIC INFLAMMATION OF THE SOFT PARTS. the capillary vessels, or fluxion, is a less prominent symptom, while the new formation of tissue and serous infiltration seem to play a more important role. The cell-infiltration of the tissue takes place in few cases, as it does in acute inflammation ; but the individual cells often attain a rather more complete development. In this process of development the intercellular tissue changes ; the connective-tissue filaments lose their tough filamentary consistency, the distensibility and elasticity of the subcutaneous tissue are impaired, and the conse- quence, as regards the coarser, palpable, and visible consequences, is that the tissue becomes more swollen and fatty, and less movable than normal. This is the first stage of every chronic inflammation. The course may vary as follows : 1. The tissue remains permanently in this state of serous, and, to some extent, plastic firm infiltration ; skin and subcutaneous cellular tissue, articular capsule, tendons, ligaments, fasciae — in short, all these connective-tissue constituents of the body which are in the above state — on section present a rather homogeneous, fatty appearance. In diseases of the joints and their vicinity we see this most frequently, and, as this swelling of the joint goes on without any reddening of the skin, it was formerly called tumor albus, a name which tells nothing of the nature of the process, but which, limited to certain forms of joint-disease, is practically serviceable. You may readily imagine that tissue which has been little altered may return from this stage of the disease to its normal state. The infiltrated serum is reabsorbed ; the cells, which have newly entered the tissue or have newly formed there, partly become connective-tissue corpuscles, and are partly destroyed ; the connective tissue itself returns to its former condition, and, if the state of affairs be not exactly as it was, it is nearly so ; occasionally a state of cicatricial thickening remains ; during the development of the chronic inflammation there may also have been small extravasa- tions or escapes of red blood-cells through the walls of the vessels, from the increased pressure (according to Cohnheim) ; these change to a brownish-red pigment, which, when present in quantities, gives a yellowish or grayish color to the tissue that has been diseased. As a result of the continued excess of nutrient material, which sometimes flows to the diseased part in chronic inflammation, the tissue-elements may become larger and thicker ; the whole tissue may increase ; it passes into a state of simple hypertrophy. But sometimes the plastic (cellular) infiltration in chronic inflammation may attain a particularly high grade ; from the infiltrated young cells new connective tissue forms in the old, so that the skin may be thickened to three or four times the normal extent ; this deposit of new tissue of similar forma- tion, in the old, is called hyperplasia by the pathological anatomists. COURSE OF CHRONIC INFLAMMATION. 405 When the thickening of the skin assumes a nodular form, it is usually termed elephantiasis in the most general sense of the term. Such hypertrophies and hyperplasias of the connective tissue, which may form in the course of a chronic inflammation, hardly ever recede en- tirely, but often remain in the same state, even when their causes have been removed. 2. If you imagine the chronic inflammation, so far as you at present know it, transferred to a mucous or serous membrane, you will acknowledge that the secretion cannot remain normal during the pathological changes which affect the tissue of these membranes. Usually it increases, there is hypersecretion y chronic inflammation of a synovial or mucous membrane may evince itself cteefly by this hypersecretion. Chronic catarrh of the mucous membranes may affect chiefly the epithelial or the connective-tissue layer or the glands of the mem- brane ; in many cases all three suffer to an equal extent. The same is the case in the synovial membrane of the joints ; some forms of chronic articular inflammation are chiefly noticeable from a very free secretion of a watery synovia ; in others, there is more thickening of the syno- vial membrane, and but little increase of secretion. 3. Chronic inflammation may also be accompanied by suppuration, and its finer changes are just as in the acute disease, except that every thing is slower. For instance, suppose there is at some part of the body a collection of wandering cells with a formation of fluid intercellular substance; at the same time, of course, the tissue in which these cells are infiltrated dies, as always happens in circum- scribed cell-proliferations. The tissue surrounding the spot first dis- eased is gradually infiltrated with cells ; and it also goes on to form fluid cellular tissue with the character of pus ; the infiltrated tissue is the more disposed to suppurate and break down when its vessels are little developed and do not supply sufficient qualitative and quantitative nutrient material to maintain the further development of the exces- sive cells. In abscess, a circumscribed cavity containing pus is thus formed, its walls are constantly being changed to pus, suppurating. All this takes place very gradually, and frequently the symptoms usually appearing in inflammation are wanting ; often there is no pain, redness, or elevation of temperature, in the affected part, and usually there is no fever. Hence this variety of abscess, which comes on chronically, is called cold abscess y for this chronic suppuration we use the term ulceration (" verschwarung "). We might also term the whole cavity containing pus a hollow ulcer (" hohlgeschwur ") ; but in common language this expression is applied chiefly to small cavities, while larger, slowly-forming ones are called cold abscesses. If you 406 CHRONIC INFLAMMATION OF THE SOFT PARTS. examine the pus from such an abscess microscopically, you will find it rich in fine molecules, but rather poor in well-developed pus-cells* This is because the pus has long been enclosed in the body, and is changed by disintegration of the pus-cells to molecules, and by chem- ical decomposition ; by the latter rich excretions of fat, especially of cholesterine crystals, are formed. The appearance of the pus to the naked eye is also changed by these metamorphoses, for it is usually thinner and clearer than in the acute disease, and has a disagreeable odor like fatty acids, and may contain fibrinous flocculi and shreds of necrosed tissue. Sometimes it is months or years before the suppu- ration of the walls of a cold abscess has gone so far as to cause per- foration of the skin. In some cases it even happened that such an abscess has existed for years, that the ulceration of its walls finally stops, and the latter are transformed to a cicatricial capsule, and the pus is thus completely encapsulated. If we have opportunity to examine such an abscess, we find in it an emulsion-like fluid, occasionally con- taing crystalline fat, and sometimes without a trace of pus-cells, so that, from the appearances, we could hardly infer that the sac in question had been an abscess, if the whole previous course did not show it. Much more rarely, in the course of time, when the abscess has ceased to grow, there is reabsorption of the fluid, a cheesy pulp being left. If the abscess has perforated outwardly, the pus is evacu- ated, and, under otherwise favorable circumstances, there may be healing, as we shall soon describe. But, for this to occur, the ulcera- tion on the inner wall of the abscess must cease, which generally only occurs when there is a sufficient development of vessels in the walls of the abscess ; under their influence the inner surface of the abscess changes to a vigorous granulation-tissue, and then it condenses and atrophies to cicatricial tissue, and the opposite walls of the cavity unite, as in the healing of acute or hot abscesses ; the pus escaping from the opened cavity grows less, and finally ceases altogether. Some time subsequently we may still feel the subcutaneous cicatrix of the abscess as a callous thickening ; but, in the course of time, this also passes off, and the abscess-cicatrix again assumes the characteris- tics of ordinary connective tissue. I will now make you acquainted with a technical name used for those abscesses which do not originate at the points where first seen, but which have moved partly from sinking of the pus, partly from the ulceration having progressed chiefly in one direction. For instance, there may be suppuration along the anterior part of the spinal column, which, following the loose cellular connective tissue behind the peritonaeum, and travelling along the sheath of the psoas muscle, finally appears as an abscess beneath Poupart's ligament. These and similar abscesses are called conges* COURSE OF CHRONIC INFLAMMATION. 407 five abscesses. The mode of healing above indicated does not take place with desirable rapidity, but, unfortunately, the general and local conditions are occasionally of such a nature that, after the evacuation of the pus, acute inflammation, with fever, attacks the abscess, and pyaemia or febrile marasmus comes on, or else, in spite of the evacua- tion of the pus, the chronic ulceration goes on slowly but steadily in the walls of the cavity. In such cases the openings of these large, often deeply-seated cavities continually pour out a thin, bad pus ; the openings of such abscesses, whether of small or large diameters, are called fistvlce. You may also imagine the above process of suppuration or ulcera- tion as transferred to a surface or membrane ; then we should have a flat or open ulcer, but, as this is an object of special and great prac- tical importance, we must treat of it in an independent chapter. 4. Chronic inflammation may take another course very like sup- puration, that is, caseous degeneration of the inflammatory neoplasia. Imagine, again, a great collection of young cells, and suppose, further, that in the centre this group undergoes molecular disintegration, and forms a cheesy pulp without separation of fluid intercellular substance. Plastic infiltration goes on slowly in the periphery of the caseous spot, by the collection of wandering cells, but the infiltrated tissue also passes into the caseous metamorphosis, and thus the central focus constantly increases. Here, also, as in suppuration, the failure of a vascularization keeping pace with the cell-formation is the local cause of the disintegration ; here is a form of ulceration that may be termed " caseous ulceration " (a vascular, dry necrosis). When these yellow spots are found in the cadaver, it is often supposed that they corre- spond to a dried collection of pus, but this is not true, or, at least, very rarely so ; most of these cheesy collections were from the first in miniature what they now are in gross, and were never fluid pus. It may very readily be proved experimentally that these caseous spots may proceed directly from the inflammatory new formation without suppuration. If, for instance, by introducing a foreign body (as a se- ton) into the subcutaneous tissue of a rabbit, you excite continued inflammation, in the course of a few days a yellow, cheesy mass forms around the foreign body ; it is true this is the same for the rabbit as pus is for a man, but it was never fluid pus. There are also morbid processes in man in which, during chronic inflammation, this caseous transformation occurs instead of suppuration. In man, the further fate of these foci varies. If the process take place in a part not too far below the surface, it may, by advancing from within outward, cause perforation ; the pulp is evacuated, and the cavity may gradually close as a cold abscess does. When this is the termination, it is usu- 408 CHRONIC INFLAMMATION OF THE SOFT PARTS. ally accompanied by secondary softening of the mass, which is at first dry and cheesy, and this fluid pulp under the microscope is found to be composed almost entirely of molecular granules, some fat, shreds of tissue, and half-atrophied cells. The above process may be seen especially often in chronic inflammation of the lymphatic glands ; but in them the spontaneous throwing off of the caseous deposit takes place very slowly, hence these fistulas of lymphatic glands often re- main stationary for months or years. Another termination is for the caseous deposit to attain only a slight extent, then to atrophy entirely, and to take up such a quantity of lime-salts as to finally form a chalky concrement, which is concen- trically enclosed by a cicatrix. But, as was stated, this only occurs in small caseous deposits. 5. There is still another form of chronic inflammation, which is ac- companied by the deposit of a peculiar substance, the so-called larda- ceous or amyloid, from the blood. But I shall not enter into this subject further, for this form of disease occurs chiefly in the internal organs, and hence has only an indirect interest for us. First, as regards the results of chronic inflammation in a purely histological view, they vary. The cell-infiltration and the neoplastic process goes on chiefly in the connective tissue, and after its termina- tion the final result is either a restitutio ad integrum or a cicatrix after the part has been destroyed by ulceration. When this process attacks muscles or nerves, the tissues suffer severely secondarily. The con- tractile substance in the muscle, as well as the axis-cylinder and medullary sheath of the nerve-filament, is not unfrequently destroyed by molecular disintegration or fatty degeneration, due to the disturbance of nutrition. Hence atrophy of the muscles and paralysis may result from chronic inflammation. How far the regenerative power of muscles and nerves goes under such circumstances is not decided. Molecular destruction and fatty degeneration may also occur without inflamma- tion of the connective tissue enveloping the muscles and nerves. But I do not think we are justified in terming such a process of fatty disintegration of the protoplasm inflammation of the muscles and nerves, as has been done by Virchow in the muscles, at least, although it must be acknowledged that, in the great majority of cases, the ap- pearance of fat-granules in the protoplasm may be regarded as the first expression of pathological (but not always retrogressive) pro- cesses in the body of the cell (Strieker). The fatty disintegration of a tissue may be the result of inflammation, or may even accompany it ; but to seek in it the nature of the inflammation, and to regard the latter as a disturber of nutrition to so wide an extent, does not seem to render it more comprehensible or of practical benefit. We regard SYMPTOMS OF CHRONIC INFLAMMATION. 409 every inflammation as accompanied by infiltration of the tissue with cells. After these general anatomical considerations, let us briefly run through the symptoms of chronic inflammation. They are the same as in acute inflammation, only they often come in a different order and in other combinations, and are usually less intense. Swelling of the diseased part is usually the first noticeable symp- tom ; it depends partly on serous, partly on plastic infiltration. The parts feel doughy, and at first quite firm ; if an abscess forms, as may happen in the course of weeks or months, fluctuation gradually be- comes more evident. We shall only perceive redness of the inflamed parts, when they lie on the surface, for, as the vessels are occasionally but little distended, it is not very intense or extensive. We may readily detect chronic inflammation of the nasal mucous membrane, or of the conjunctiva, by the swelling, redness, and increased secretion. Chronically inflamed skin gradually assumes a bluish or brownish-red color. But, if the inflamed parts lie deep, the skin is not discolored, and only becomes red when the deep chronic inflammation finally im- plicates the skin, as in the perforation of cold abscesses. Pain is one of the symptoms of chronic inflammation that varies most ; in some very tedious cases it is entirely absent, but in other cases may be very severe, having a tearing, boring character, sometimes appearing spon- taneously, at others only on pressure, or on merely touching the parts. The funcUonal disturbance depends essentially on the pain and on the anatomical changes in the parts. Seat, the temperature appearing elevated when the hand is laid on the part, is not usually marked, or is very slight. Fever is a symptom not necessarily pertaining to chronic inflam- mation ; it usually appears only when the inflammation assumes an acute character, as not unfrequently occurs during its course, especially when the body has been much debilitated by long-continued suppura- tion. Then we have the so-called hectic fever, a febris continua, or simply remittent, with great differences in the morning and evening temperature of the body, a fever with steep curves. According to my idea, this hectic or consumptive fever results from continued absorp- tion of the products of inflammation, especially of disintegration ; hence it is most frequent and most intense from rapid breaking down of the inner walls of large abscesses, and in rapid progressive ulcera- tion. This fever often runs its course with rapid emaciation, night- sweats, and diarrhoea. Few patients stand such chronic suppurative fever long ; though I observed a boy fourteen years old, with a fistula remaining after resection of the head of the femur and general larda- 410 CHRONIC INFLAMMATION OF THE SOFT PARTS. ceous disease, a whole year, during which he had a continued febris remittens ; he finally died from general dropsy. The course of chronic inflammation may be classed under two gen- eral heads. In the first case, even the commencement of the disease is indistinct, and can scarcely be stated with any certainty by the pa- tient. Sometimes it is a swelling, a moderate pain, or a slight dis- turbance of function that has called attention to a morbid state. Cases which have begun so insidiously usually maintain this character in their further course. In other cases, the chronic inflammation is a remnant of an acute process ; the chronic course is interrupted from time to time by acute attacks, with fever. We can say least that is definite about the duration of chronic inflammation in general, as this above all things depends on the exciting causes, to which we shall soon come. I only entreat you to bear in mind that chronic inflammation, like the acute, has a tendency to terminate, to have a typical end, for the new formation never goes beyond the develop- ment of certain characteristic metamorphoses of tissue, which lead to development of connective tissue, or of a cicatrix in some way, unless the diseased tissue is destroyed by disintegration. Why it is important to remember this will be clearer to you when we treat of the limitation of other new formations, such as actual tumors. Of course the new formation attains no typical end when its causes can- not be removed, or do not spontaneously disappear, and when organs are destroyed that are necessary to life, or when the strength is ex- hausted by suppuration. LECTURE XXIX. General Etiology of Chronic Inflammation. — External Continued Irritation.— Causes in the Body.— Empirical Idea of Diathesis and Dyscrasia.— General Symptomatology and Treatment of Morbid Diatheses and Dyscrasia?. 1. The Lymphatic Diathesis (Scrofula) ; 2. Tuberculous Dyscrasia (Tuberculosis) ; 3. The Arthritic Diathesis ; 4. The Scorbutic Dyscrasia ; 5. Syphilitic Dyscrasia. To-day we come to one of the most important parts, not only of this section, but of all medicine, that is, to the causes of chronic in- flammation. We saw how acute inflammation resulted from an irri- tant acting once, and varied according to the anatomical condition of the irritated part, and the nature and extent of the irritation, but that it ran a relatively short and typical course. Now we have to deal with inflammations that last several months or years ; here there must be a continued cause, a long-acting irritation, or some abnormal reaction to simple irritation. These continued irritations may be of CAUSES OF CHRONIC INFLAMMATION. 41 1 a purely local character ; let us consider them for a moment. When small animals, like the itch-insect, take up their abode in the skin, as they dig burrows like a badger's in the superficial layers of the cutis, lay eggs, and there lead their laborious life, they cause constant irri- tation of the skin ; to this is added the scratching, and a chronic in- flammation of the skin is thus caused and kept up. If spores of fungus locate in the epidermis, and there begin to grow and to mul- tiply to millions of small vegetable organisms, the skin will be placed in a state of continued irritation by these little foreigners ; and va- rious chronic cutaneous eruptions will result, such as favus, herpes tonsurans, pityriasis versicolor, etc. If a pressure or friction act moderately but continuously on the skin, it also is a chronic irritation, which is particularly apt to induce thickening of the part of skin af- fected. The callous spots on the heel and many corns are the result of the continued friction and pressure induced by our modern foot- coverings. In the same way the workman who uses axe and hammer a great deal has callosities in the hand, the shoemaker has them on the outer side of the little finger and hand where he daily draws on the pack-thread, etc. [We see the same thing much more markedly on the side of the left thumb and forefinger in plasterers, from hold- ing their plaster-board ; and at the upper and posterior part of the front leg of some horses, from lying on their iron shoes.] Sometimes foreign bodies in the tissue keep up a continued chronic irritation in the surrounding parts. Continued or often-repeated chemical irrita- tion of the tissue may also induce chronic inflammation ; for instance, chronic gastric catarrh may be caused by the repeated use of schnaps or strong liquors. Continued stagnation of blood and lymph, as well as their coagulation in the vessels, first induces hyperplasia of the walls of the vessels, and of the parts immediately around them, distention and tortuosity of the vessels, and thickening of the tissue ; the skin of the leg is particularly exposed to this disease when there is any continued opposition to the escape of venous blood from the extremity. When we have to treat chronic inflammations that may be traced to such external continued irritations, of which many more illustra- tions might be given, the results will be favorable. We get rid of the animal or vegetable parasites, the foreign bodies, the continued pressure, chemical influences, etc., and the chronic inflammation will disappear spontaneously. So far we have supposed a local irritation acting continuously on healthy tissue ; if you suppose a tolerably se- vere irritation acting once on a tissue already diseased, you cannot expect the conditions to prove as favorable as in a simple traumatic inflammation of healthy tissue ; but it is probable that the results, 412 CHRONIC INFLAMMATION OF THE SOFT PARTS. even of the single irritation, will be different, possibly more continued, because the conditions in the tissue will not be so favorable for typical removal of the disturbance. Suppose a portion of skin already suf- fering from chronic inflammation to be superficially contused, this sin- gle irritation may induce chronic suppuration, or even progressive ul- ceration, which, under normal conditions, would quickly have gone on to new formation of epidermis and healing. The cases where we find such purely local causes for the origin and continuance of chronic inflammation are comparatively rare. In the great majority of cases the cause is not so evident; the case must be watched and tried in various ways before we can obtain any clew to the etiology of most chronic inflammations and diseases. We have not here mentioned miasm and contagion from the domain of general etiology ; and we may leave them out of the question, for there is nothing to show that chronic inflammation may arise from a single action of contagion or miasm. It is true there are chronic malarial diseases, such as intermittents, etc. ; but there the cause of injury acts continuously, and not unfrequently the disease can only be cured by removing the patient from the miasmatic atmosphere ; hence this case corresponds to a continued external irritation. The same is true of repeatedly catching cold, where the new attack affects the body already diseased, and thus induces chronicity of the process. But all this does not suffice for the etiology of chronic inflammations; we must also look for the causes in certain congenital or developed conditions of the whole body. Let us hear what experience teaches on this subject. On careful observation we first notice that certain forms of chronic inflammation constantly recur in certain organs and certain parts of the body ; that at the same time they show themselves chiefly at cer- tain ages and in persons presenting some similarities in their external conditions. Thus we see children of the same class, who are pecu- liarly disposed to chronic swelling and suppuration of the lymphatic glands, joints, and bones, other persons who are chiefly affected by insidious inflammation of the lungs, others who are particularly liable to colds and have pains in the different muscles and joints. We also see that such persons, who are constantly being attacked in the same way, transfer their individual pathological peculiarities to their de- scendants ; that those leaving such legacies have in their turn received them from their fathers or mothers. To obtain some clear idea of individual morbid predispositions in this chaos, persons predisposed to certain chronic diseases were divided into groups ; thus, in a purely empirical manner, men were divided, according to morbid dispositions or diatheses, into lymphatic, scrofulous, tuberculous, rheumatic, etc. ; CAUSES OF CHRONIC INFLAMMATION. 413 terms which at first merely meant that the scrofulous, for instance, were especially predisposed to glandular diseases ; the tuberculous to the development of ulcerating nodules, etc. Subsequently this group- ing was carried further, and it was concluded that a certain morbid condition of the physiological processes of the entire body must lie at the root of such predispositions. A morbid material, or essence, a materia peccans, was supposed to exist in the body ; the most natural bearer of this was the blood, for this passed through the entire body, and its condition certainly gave a measure for the more or less normal or pathological condition of the entire body. The word dyscrasia (a bad mixture) indicated such a pathological condition of the blood ; hence a scrofulous, tuberculous, etc., dyscrasia were spoken of. It is, however, a strange idea to burden the blood alone with the patho- logical changes of the whole body, and assume, as it were, that infec- tion of the whole body resulted from it. This could only be acknowl- edged in cases where an abnormal material was introduced into the blood from without, as we have seen to be the case in poisoned wounds. But this is not the case in the dyscrasiae under consideration, or at least it is only partially so ; but the morbid dispositions develop in the body itself from causes little known, if they be not handed down as an inheritance from the parents. The blood is no more absolutely stable than any other tissue of the body ; it is constantly being renewed, partly used up and again renewed, etc. ; we do not certainly know the source for the renewal of the blood-corpuscles ; you know from physiology that the serum of the blood is constantly being regenerated from the lymph, and this again from the chyle- vessels of the intestines, and you also know that fluid constituents from the blood are excreted by kidneys, lungs, and skin. How little we know of these things, and how complicated even these little affairs are ! I lead you to this consideration to add that normal blood can only form from a healthy body, and the reverse ; hence that we cannot physiologically speak of a one-sided disease of the blood. But there would be no use waging war against and trying to root out the words dyscrasia and diathesis, now firmly embedded in medical lan- guage. It would do science no harm to use them forever with the above meaning ; we must have a name for these things, for they are not myths, but are facts that have been observed for centuries, although their significance has varied greatly. We may go too far in classify- ing persons in this matter, if we ascribe to every one a pathological diathesis, or try to place every patient in one of the chief divisions. Although there might theoretically be a certain amount of correctness in supposing that in our present state of cultivation there was no such thing as an absolutely healthy man, still, it would be very senseless 414 CHRONIC INFLAMMATION OF THE SOFT PARTS. to try to maintain this in practice. And you must not suppose that it is always so easy to class every patient in certain groups, just as plants are analyzed and their systems determined, for all classes of men may breed with each other ; moreover, some abnormally-formed individuals may become perfectly normal in the course of time, and the reverse ; thus a number of middle forms naturally result, which defy any classification. There are now, as there have at all times been, physicians who are too skeptical about the existence of a gen- eral morbid disposition to certain forms of disease, and only acknowl- edge local and partly only accidental irritations as causes. Such a hyperskeptical current ran through modern medicine a short time since, and was perfectly justified, for the crasis doctrine had become so luxuriant, that there was scarcely a variety of inflammation, scarcely a disease, in fact, which was not based on some specific crasis. Who- ever observes independently and carefully, and at the same time has the opportunity of seeing a variety of patients, will certainly arrive at the correct view in the course of time, and will neither throw him- self too unreservedly into the arms of the crasis theory, nor set aside, as illusions and deceptions, the experiences of centuries. It is a ques- tion whether it be of any practical value to use such terms as scrofu- lous or syphilitic inflammation, if it would not be better to regard the chronic inflammatory processes without any regard to their origin. The future will decide this question ; at present I deem it my duty as teacher to clear your views on these points as much as possible, and to place you in a position to be able to understand all your colleagues speaking on these subjects, no matter to what school they belong. But enough of this general explanation ; let us draw a brief sketch of the different diatheses and dyscrasiae : 1. The lymphatic or scrofulous diathesis {scrofula). This tendency to disease exists chiefly during childhood, though more advanced ages are not free from it. Persons with this diathesis, especially children, are greatly disposed to chronic inflammatory swellings of the lym- phatic glands, even after inconsiderable irritations, to certain inflam- mations of the skin (eczema, impetigo), especially of the face and head, to catarrhal inflammations of the mucous membranes, especially of the conjunctiva, more rarely of the intestinal canal and respiratory organs, to chronic inflammations of the periosteum and of the synovial membranes of the joints. As regards the swelling of the lymphatic glands, especially of the submaxillary and occipital, it has been asserted that it is merely a result of irritation from dentition, or of the eczematous eruptions on the head, of the inflammations of the eye, ear, etc. ; this is partly correct, but even taking this view, that all swellings of the lymphatic glands are secondary, even then for the SCROFULA. 415 glands to swell after dentition, for instance, there must be an abnor- mal irritability of the lymphatic system such as does not exist in all children ; moreover, such local irritations cannot always be found for the affections of the bronchial and mesenteric glands, which are almost as frequent. It is also a morbid state for the swellings of the lymphatic glands to last longer than the irritation, and even subse- quently to increase without apparent cause. It may be acknowledged that some of the above affections — for instance, part of the scrofulous diseases of the joints— are caused by injuries, contusions, etc. ; but the fact that they take a chronic and to some extent entirely peculiar, constant course, is due to abnormal condition of the tissue, which ab- normal condition is so spread over the entire body that it cannot be regarded as a purely local, but must be considered a universal condi- tion. Various attempts have been made to explain this local and gen- eral abnormity, especially to refer the " chronicity " to a continuance of the irritation, so as to escape the enigma of an organism reacting differently to one irritant from what it does to another. Hence it has been assumed that the matters formed by a chemical change in the tissues, from whatever cause, were not taken up by the lymph- and blood-vessels and removed from the diseased organ, but remained there and induced continued inflammatory irritation. I am far from denying that this takes place occasionally; but even if it were always true, the peculiarity just mentioned of this or that organ still remains abnormal in these persons. In short, we do not thus escape the fact that these persons differ from the majority either in certain tissues or in toto. Children fall times without number on knee, hip, or elbow, without any disease resulting, or else the effects pass off in a few days, even without treatment and when there has been consid- erable bruising, as shown by the extensive extravasation, swelling, and pain. But even after slight injuries some children have chronic inflammations of the joints ; these are exceptions; there is, however, no objection to regarding them as a peculiar pathological race. At- tempts have been made to diagnose the scrofulous diathesis from the general appearance and condition of the child. The following is the picture usually drawn of a scrofulous child : blond hair, blue eyes, very white skin with thick cellular membrane, thick lips, pot-belly, voracious appetite, and tendency to constipation {torpid scrofula). In practice you will meet some of the originals of this portrait, but you will see many other cases not at all like it, which nevertheless suffer from typical scrofula. I do not attach much importance to these external symptoms. In regard to the course and terminations of chronic inflammation in scrofulous children, we may make the fol- lowing remarks : In a few cases the chronic inflammatory swelling 436 CHRONIC INFLAMMATION OF THE SOFT PARTS. sooner or later subsides entirely, and the parts become perfectly nor- mal. The course with suppuration is the most frequent, and accord- ing to the special nature of the case this may be quite acute, as it is in inflammation of the submaxillary glands and in inflammations of the joints. Often the disease remains chronic for years ; abscesses, fistuke, ulcers, etc., form. Early suppuration occurs, especially in somewhat emaciated, debilitated, badly-nourished children, who are very liable to fever (erethitie scrofula), and its prognosis is very bad. The termination of the inflammation in caseous degeneration is not rare ; it is particularly frequent in the lymphatic glands ; of course it must have a very bad effect on the general nutrition, when the mesen- teric glands are degenerated in this way, and the chyle-ducts thus mostly obstructed ; incurable atrophy of the entire body may thus be induced. The lymphatic diathesis is in most cases congenital, and is transmitted from generation to generation ; but it may also be devel- oped by improper modes of life. Among the most injurious causes are given : chief or exclusive diet of potatoes, flour, or sour bread ; unhealthy, damp dwellings ; lack of cleanliness, fresh air, etc. It is indeed difficult to prove if all this be correct ; at all events, if the above causes always induced scrofula, it would be much more frequent than it now is among the poor. To state in a few words what is at present understood by a lymphat- ic constitution or scrofula, it may be considered — 1, as a disposition to chronic inflammation of the skin, bones, and joints, in which the inflammation may lead to development of granulations, of pus, and to caseous degeneration ; 2, as existing when swellings of the lym- phatic glands, even when induced by temporary irritation, continue long in the same state, or even increase without new peripheral irri- tation. We shall here pass at once to the treatment of scrofula in general. First of all, the diet should be regulated ; good animal food, eggs, and milk, well-baked wheaten bread, occasional baths, residence in fresh, healthy air, a hardening mode of life, are the most important reme- dies, but from the circumstances they are often the most difficult to employ ; in prescribing the diet, special attention must often be paid to the individual case, especially as to whether there is a tendency to lardaceous disease or atrophy, whether the digestive organs are nor- mal, or were ruined in youth by improper diet. As the disease is very common among the poor (without the rich being free from it, however), these dietetic and hygienic rules are particularly difficult to follow. The number of internal anti-scrofulous remedies is very great ; the object is not, as was formerly supposed, to introduce a specific remedy as an antidote to some unknown poison circulating in the SCROFULA. 417 blood, for the latter does not exist ; but the treatment should be purely symptomatic, and usually general. From the above, you see that scrofula is not a materia peccans in the blood, but only a debility of the organization in some direction, a more or less intense predisposi- tion to peculiar forms of disease. This is a decided difference from, and an advance beyond, the old view of the disease. From my ex- planation you may also understand those recent skeptics who think that all chronic inflammations in children are of similar origin, and that it is consequently unnecessary in each case of chronic inflamma- tion of the lymphatic glands, or in articular inflammation, to add that it is scrofulous or depends on a lymphatic diathesis. Possibly these expressions may disappear in the course of time, as they will be ren- dered unnecessary by greater clearness of ideas, but it is not correct to say that all chronic inflammations in children have the same origin, for some of them may be due to hereditary or developed syphilis; and in adults there are many other constitutional predispositions besides those that have hitherto been termed scrofulous or tuberculous, and which consist in the predisposition to chronic inflammations ending in suppuration, caseous degeneration, and ulceration. It seems to me that there can be no doubt that these processes are, to a certain ex- tent, opposed to other forms of chronic inflammation — for instance, to those depending on interstitial proliferation of connective tissue (cirrhosis of the liver, morbus Brightii, gray degeneration of the medulla spinalis, etc.). Many things have been tried to improve the lymphatic diathesis. Formerly purgatives were occasionally given, and in England particu- larly small doses of mercury were administered ; this is well suited to fat scrofulous children ; burnt sponge, folia juglandis regiae, herba jacea, acorn-coffee, and bitter medicines, were recommended, and are still used. At present, cod-liver oil is most used as an anti-scrofuletic, as it is not only considered to have a specific action against the scrofu- lous diathesis, but is very properly prized as exceedingly nutritious, and hence is especially used in emaciated scrofulous children ; in fat children it might even prove injurious. Some of the preparations of iodine act very well in scrofula ; but they should be employed care- fully, and in fat rather than in atrophic children ; iodide of iron is best in pale fat children, with fungous inflammations of the joints. The easily-digested preparations of iron are very valuable remedies in scrofula patients with anaemia. Salt-water baths also act beneficially ; these may either be used at the springs, in Germany, for instance, at Kreuznach, Rheme,Wittekind, Coblenz, Tolz, Reichenhall ; in Austria, at Hall, Tschl ; in Switzerland, at Rheinfelden, Schweizerhall, Lavey, or Bex ; or, they may be prepared at home by adding from, according 27 418 CHRONIC INFLAMMATION OF THE SOFT PARTS. to the size of the bath, one to three pounds of salt to a warm bath. For a large child, sea-baths may be recommended ; for weakly chil- dren, warm baths with the addition of malt and aromatic herbs. In fat scrofulous children, Niemeyer recommends wrapping the whole body in wet sheets ; I have seen good results from this in some cases. Some physicians also recommend sulphur-springs, especially the hot ones, in scrofulous diseases of the joints ; so far, I have seen more harm than good from them. You see there is no lack of remedies ; still we rarely succeed in improving the constitution bj' them, and can* not prevent relapses in all cases. Sometimes, too, the local process attains such a grade as to be of itself dangerous to life, and the local remedies must be mostly relied on. As before stated, the tendency to these diseases greatly decreases in the course of years ; but many children die of the diseases of the bones and joints. 2. The tuberculous dyscrasia. Tuberculosis. The name of this disease comes from tuberculum, the nodule, because chronic inflam- mations due to this disease appear as small nodules, or tubercles, at first scarcely as large as a millet-seed, often microscopic. If you analyze one of these nodules with the microscope, you find it to con- sist of a number of medium-sized, round cells, which increase in the periphery of the nodule, while in its midst the short-lived cells have already broken down to a fine, molecular, dry pulp, which, when the nodule is very large, becomes yellow and caseous. The recent investigations of Schuppel, Lanyhans, Mindfleisch, and others agree that large multinucleated masses of protoplasm, so- called giant cells, are often found in the centre of young tubercles ; we shall speak of these further when describing the new formation of bone. The nuclei in the giant cells of tubercle are often exqui- sitely arranged about the periphery. But these giant cells do not always occur in tubercles. We often see in the peritoneum an in- discriminate grouping of large and small cells as a commencement of tubercle ; and near these distinctly round or very irregular but sharply-bounded new formations there are more diffuse (tuberculous) infiltrations, which can scarcely be distinguished from ordinary in- flammatory infiltration, except by the fact that the cells are nearly double the size of wandering cells which form the first cellular infil- tration in acute inflammation. A great peculiarity, especially noticed by Rindfleisch, is that tu- bercle often develops on and in the walls of small arteries and lym- phatics, but very rarely in veins. There are various views about the origin of the cells which form tubercles. If they are wandering cells, they must enlarge very rap- idly soon after their escape from the capillaries and veins ; on the TUBERCULOSIS 419 whole, modern observers are little inclined to this view. Rindfleisch, Kundrat, and others hold that tubercle-cells develop mostly from proliferation of endothelium, especially that of the blood-vessels, lymphatics, and serous membranes. Rindfleisch thinks they may also develop from the muscle -cells of the arteries ; Ziegler has proved that they may result from confluence of wandering cells. Fig. 71 a. Giant cells from tubercle in various stages of development. After Langhans. Magnified about 400. Regarding the subsequent fate of these small neoplasia, the most essential and peculiar thing about them is that vessels do not de- velop in them any more than in purely epithelial neoplasia, although their periphery is very vascular. Very rarely cases occur where the tubercles gradually become filament-nodules. While every other neoplasm is accompanied by growth of vessels, in tubercles this is wanting entirely, as has been lately shown again by Rindfleisch i JTeitzmann, and others. The result of this is that the young neo- plasia cannot live long ; it dies in the centre, but the periphery sur- vives. The dead centre occasionally breaks down into a fine, punc- tate, amorphous substance, which to the naked eye appears as a 420 CHRONIC INFLAMMATION OF THE SOFT PARTS. Fig. 71 b. a, Minute tubercles in the peritoneum. 6, Minute tubercles on a cerebral artery, a and b slightly mag- nified from preparations of Eindfieiseh. c, Development of minute tubercles in the peritoneum. After Kundrat. Magnified 500. dry, cheesy pulp ; in short, as a result of its lack of blood-vessels, the tubercle undergoes cheesy degeneration. Possibly the tubercle might enlarge ad infinitum by new cellular infiltration of the tissue around the primary focus, but this rarely happens. The large cheesy deposits found in the brain, testicle, etc., in most cases result from confluence of numerous small nodules, of which we often find num- bers in the vicinity of large caseous nodules. This brings us to the relation of the tissue to the tubercle scat- tered through it. I would here remark that the miliary nodules usually appear in large numbers in the organ or part affected. Just around the tubercle there is generally a subacute inflammation with free cell-infiltration and vascularization ; this may lead to suppura- tive softening of the tissues, chronic abscesses, and ulceration ; thus a cavity is formed which contains pus, softened shreds of tissue, and caseous tubercle. The inflamed parts around the tubercle may be drawn into the caseous degeneration, and a large cheesy deposit TUBERCULOSIS. Fig. 71 c. 421 a, Minute tubercle of a cerebral artery. Magnified 100. &, Commencement of the cellular growth in one of the small cerebral arteries. Magnified about 1,000. (I do not think it can be proved whether the multinucleated cells are wandering connective-tissue, endothelial, or muscle cells, or whether they are due to the transformation of the intima to protoplasm.) Both drawings are from preparations of Rindfleisch. forms, which shall contain the primary tubercle ; this may subse- quently soften by peripheral suppuration, or after encapsulation may become calcareous. If tubercles form in mucous membranes, as in the larynx, intestine, ureters, bladder, or uterus, besides the tuber- culous infiltrations and ulcerations there is purulent catarrh, with free detachment of epithelium, especially in the pulmonary alveoli 422 CHRONIC INFLAMMATION OF THE SOFT PARTS. (desquamative pneumonia, Buhl). In all of these cases the diseased part may be, but unfortunately rarely is, encapsulated by firm con- nective tissue, after undergoing metamorphosis ; and after evacuation or calcification of the contents, the capsule may shrink to a firm cic- atrix. But in serous membranes, and especially in the peritoneum, the inflammation caused by presence of tubercles leads at once to development of connective tissue, which not only encapsulates the nodules, but causes such an intimate adhesion of the intestines to each other and to the walls of the abdomen, that they can scarcely be separated on autopsy. As regards the occurrence of tubercles in different organs, none are exempt, though some are more predisposed than others. Tuber- cles are most frequently found in the lungs, especially at their apices; there are usually many at one time ; they unite, the walls of the bronchi are implicated in the process, they are destroyed, and the caseous, partially-softened contents of the tubercles are coughed up; sometimes blood-vessels are ruptured, giving rise to spitting of blood or pulmonary haemorrhage. A space thus left by softened tubercle is called a cavity. It is not our object to enter more into detail ; you will hereafter learn enough of this unhappy disease in the clinic. Next to the lungs, the most frequent location of the disease is in the laryngeal mucous membrane, then in the intestinal mucous membrane, even in the rectum, where the tuberculous ulcers and ab- scesses also acquire a surgical interest. Tubercles also occur in the bones, especially in the spongy ones, such as the calcaneus, bodies of the vertebrae, and upper epiphyses of the tibia. Although the lymphatic glands are often diseased in tuberculosis, miliary tubercle proper is hardly ever seen in them; still Schuppel found them there also. The views as to the etiology of tuberculosis have changed wonder- fully of late years. Formerly it was not doubted that it was partly an idiopathic disease, partly due to hereditary predisposition. Hence we spoke of a tuberculous as we did of a scrofulous diathesis, and the two were considered as related, although not identical. JLaennec started the view that the small nodular neoplasias (gray miliary tuber- cles) were the primary development, and by confluence and growth led to the destruction of the affected tissues. The division of tubercles into miliary gray points and into cheesy nodules, the very peculiar acute miliary tuberculosis, the connection of tuberculosis with other and especially with chronic suppurative inflammations and those tending to caseous degeneration, were gradually developed and in many places remain obscure, although the idea of tubercle has been rendered more limited and precise by Vtrchotv, so that at present TUBERCULOSIS. 423 every new formation that has undergone caseous degeneration is not considered as tubercle. It was reserved for Buhl, by careful experi- ments, to arrive at the idea that acute miliary tuberculosis was the pro- per type of tuberculous disease ; he found it mostly combined with old caseous or purulent inflammatory foci ; he made the bold assertion that it always resulted from absorption of substances from these foci. According to this, tuberculosis was an infectious disease, a sort of nodular exanthema on and in internal organs, caused by the absorp- tion of an injurious substance, particularly from old caseous points of inflammation in the lymphatic glands, lungs, bone, etc., and some of these particles may have a specific infectious action, as emboli in the lymph- and blood-vessels. Investigations of late years have shown that many destructions — in the lungs, for instance — which previ- ously had been considered due to miliary tuberculosis as a matter of course, are inspissated, caseous, and partly-softened spots, that must be regarded as the result of a simple chronic, ulcerative inflammation, as no miliary tubercles are found in them, but only large-celled infil- tration. It seems, indeed, that even in pulmonary tuberculosis the formation of true tubercle is to be regarded as secondary and fre- quent, but by no means necessary. Niemeyer deserves great credit for his practical application of this view, according to which a diathe- esis to chronic purulent inflammations of certain organs, but not the tuberculous infection, would be congenital. This view is of late greatly supported by the fact that attempts to render animals, espe- cially Guinea-pigs and rabbits, tuberculous, have succeeded. In these little animals irritation of very short duration excites inflammation with caseous purulent products, and from this focus results a tuberculous dyscrasia, which evinces itself in the production partly of miliary tuber- cles, especially on the serous membranes, partly of yellow nodules in the lung, liver, spleen, etc., and causes death. These very interesting ex- periments, which were begun by Villemin, and repeated by Lebert and Wyss, Fox, Klebs, Cohnheim, Waldenburg, Menzel, and others, with the same result, but with different interpretations, seem to me to prove, what I have always maintained, that tubercle is merely a peculiar form of inflammatory new formation ; that is, that BuhVs view is correct. But it is important to remember that these inoculations only succeeded in animals having a tendency to cheesy degeneration, as rabbits, etc. Hindfleisch says these animals become tuberculous whenever they have a chronic inflammation. In dogs the inoculation does not succeed. If from what has just been said we recognize to the full extent the immense progress recently made in the knowledge of tuberculosis, still we must not fail to see that it does not fully explain the interest- 424 CHRONIC INFLAMMATION OF THE SOFT PARTS. ing connection between some chronic surgical diseases and tubercu- losis of internal organs, especially of the lungs. Although there are a good many cases where pulmonary tubercles follow chronic sup- puration of bones or joints, and caseous degeneration of swollen lymphatic glands, just as often death of the patient results, after years of illness, from exhaustion, and on section we do not find a trace of tubercle. Under some circumstances, too, there is no ab- sorption of the caseous masses, or else, if absorbed, they do not in- duce tubercle. This would go to prove that there must not only be a disposition of inflammatory foci to become caseous, but also a dis- position to the dissemination of tubercles, and that these two dispo- sitions are not necessarily combined as in the rabbit and Guinea-pig. The fact that around a small inoculation a cheesy focus forms, and from this disease is disseminated to the internal organs, is a peculiar- ity of these animals, as it is of some human beings. This peculiarity is called the tuberculous diathesis. Nor must I hide from you that some pathologists only acknowledge a frequent coincidence between chronic suppurating or caseous foci and tubercle, and refer both to a common, unknown cause. But all this cannot prevent me from rec- ognizing the exceeding value of the above-described recent observa- tions, and regarding them as one of the greatest advances of modern pathology. The new etiology of tuberculosis has given treatment a peculiar, and, at a casual glance, a changed position. We now have to ask ourselves the following question : Is there any remedy or mode of treatment by which we can prevent a person, who has on or in him any caseous pus, from being infected with tuberculosis ? To this we must at once say no. The mode of infection is so little known, that on this account alone we could not speak of its prevention. The in- terval between the development of the primary point of inflammation and the succeeding tuberculous infection is entirely incomputable. In some cases the formation of tubercles in the lungs appears to fol- low almost on the heels of chronic bronchial catarrh, while in other cases the two forms of disease are separated by years. Typical tuber- cles may also dry up and become indurated in various ways, or they may rapidly increase, unite, and soften. In short, the variety of the process is very great. But all this gives no starting-point for the treatment. As regards hereditary influence, to which so much im- portance is properly attached in tuberculosis, some enigmas have been solved by, and some former experiences readily adapt themselves to, the new views. If true tubercle could only develop from infection through the patient himself, of course there could be no talk of direct inheritance of tuberculosis in the strict meaning of the term. Only GOUT. 425 the tendency to chronic inflammations, ending in suppuration and caseous degeneration, is hereditary ; in other words, the scrofulous diathesis, not the tuberculous, is hereditary. We must bear this in mind ; the experience of family physicians agrees with it entirely ; but we must understand that such general rules are only true in theory. The hereditary tendency to diseases of certain organs, and to certain forms of disease, is such a complicated question that we should be very reserved in stating general laws about it. Apart from the occasional accidental complications, such as meningitis, haemorrhages, pneumothorax, empyema, peritonitis from perforation of intestines, pyaemia, etc., tuberculosis may prove fatal by extensive suppuration and the rapid febrile marasmus, or by amyloid degener- ation of internal organs due to the suppuration, or, lastly, by acute miliary tuberculosis, i. e., by an extensive eruption of tubercles in internal organs, accompanied by general poisoning, where the pa- tient is in a typhoid state. In the earlier stages recovery may take place, but leaving a tendency to relapse. If we put together what may be said about the indications for treatment of tuberculosis, it would be about as follows : We cannot prevent either the development or progress of tubercles. Hopeless as this sounds, it remains to be added that medical care may accom- plish something in hindering the development of those processes which are so often followed by tuberculosis. The early, careful, general dietetic and local treatment of chronic diseases of the bones and joints, and even the amputation of limbs, or the resection of bones at the proper time, may prevent the development of tubercle. In the same way, great care of catarrhs of all sorts, and their most perfect removal, is undoubtedly the most effectual thing we can do to remove the tuberculous infection. In tuberculosis the treatment is the same. All the remedies, baths, and places for treatment, that are prescribed, have for their object — 1, to remove or diminish the existing catarrh or other primary disease ; 2, to improve the nutri- tion of the patients, who are generally emaciated ; 3, to avoid every thing that can render the patients feverish. T must leave it for the lecturer on clinical medicine to make you better acquainted with the important principles of treatment in this frequent and fearful disease. 3. Arthritis, or gout, is a tendency to disease which usually ap- pears first about the thirtieth to the forty-fifth year of life and later ; it is often confounded with chronic rheumatism, but really differs from it considerably. True gout is a rare disease with us, and is dis- tinguished from rheumatism by the fact that it occurs in attacks, often recurs only once a year, or at stated intervals, while meantime 426 CHRONIC INFLAMMATION OF THE SOFT PARTS. the individual remains perfectly well. Gout is a disease of the rich, and, as old physicians who had it themselves used to say, of wise men. It occurs chiefly in men who lead a comfortable, inactive life ; it not unfrequently descends to the next generation, but always appears first after middle age. Harvey, Sydenham, and many other cele- brated physicians, suffered from gout. The inflammations occurring in gout are chiefly limited to certain joints, and the parts around them. The joint between the metatarsus and the first phalanx of the big toe is affected particularly often ; this is the seat of true podagra. The wrist and the joints of the phalanges may also be attacked by gout ; here it is called chiragra. The skin over the joint is impli- cated in these inflammations. During the attack it becomes bright red and very sensitive, as in erysipelas ; and, in rare cases, ulcers may form during this process. Arterial thickenings (atheroma of the artery), with their occasional results, cerebral apoplexy and senile gangrene, are not unfrequent in arthritic patients. Corpulence, dis- eases of the liver and kidneys, may also accompany gout ; gravel, especially a fine granular excretion of uric or oxalic acid from the kidneys into the bladder, is not unfrequent, but, just as frequently, large renal and vesical calculi develop. In the diseased joints and sheaths of the tendons considerable quantities of urates have been seen, occasionally in such quantities that they covered the articular surfaces and capsule like a white granular coating. An attack of gout is usually preceded for some time by a general feeling of being out of sorts, which disappears as soon as the inflammation attacks some external point, usually a joint. These inflammations last two or three weeks, and then subside, often leaving permanent thickening of the joint ; but in other cases the diseased limbs often remain un- changed for years. In some old arthritic patients these stone-like gout-nodules are also found in the skin, as in that of the ear, as well as in the joints and sheaths of the tendons. If these nodules break off, the masses of lime and urates may be scooped out with an ear- spoon ; the complete suppuration and closure of these open and very painful gouty nodules then last for months. Operations with the knife in such cases should be carefully avoided. The ordinary attack of podagra never ends in suppuration, always in resolution. From this etiological relation of the abnormal deposits of uric acid to the joint affection, gout has also been called arthritis urica. The treatment of the attack of gout, of the gouty articular in- flammation, is to be distinguished from the general treatment. The former almost always runs a typical course, which is not materially changed by treatment. The first indication for medical aid is to al- leviate the pain by moderating the inflammation ; for this purpose SYPHILIS. 427 ice might answer very well, if there were not certain reasons for fearing its effects, for, from the frequent presence of atheroma of the smaller arteries, great cold might induce gangrene. There is not much to be said against the application of cold compresses, cold fo- mentations with lead-water, weak solutions of nitrate of silver, or local applications of leeches ; but many gouty patients prefer greas- ing the joint and wrapping it in wadding. Profuse diaphoresis, in- duced by hot tea and hydropathic packing, is said to shorten the attacks. In the constitutional treatment of the arthritic diathesis, mineral waters take the first rank. Gouty patients should be ad- vised to use the waters of Karlsbad, Kissingen, Homburg, Vichy, and other saline springs, also the thermal waters of Teplitz, Gastein, Wiesbaden, and Aix-la-Chapelle. But we may expect an acute attack of gout to follow the use of warm baths. 4. The scorbutic dyscrasia manifests itself in great fragility of the capillary vessels, and consequent subcutaneous haemorrhages, which result from ruptures of the vessels or from diapedesis, and may be induced in frogs by poisoning them with ordinary salt. This disease is supposed to be due to dissolution of the blood, without any accurate description being given of the blood-change causing the change in the vessels. The disease is almost entirely endemic, for instance, on the shores of the Baltic, and, in a surgical point of view, is not very interesting. When treating of ulcers in the next chapter, we shall refer to it again. 5. The syphilitic dyscrasia. Although I do not propose to in- clude syphilis in the subjects of these lectures, still, for the sake of completeness, I must make some remarks on it. This, like the above diathesis, developed in man at some time, but now it is spread entire- ly by inoculation. The person inoculated is syphilitic from the mo- ment the virus takes effect. In speaking of syphilitic diseases in general terms, three different diseases are included : (1) gonorrhoea, a blennorrhoea of the vagina, then of the urethra, which thence oc- casionally extends to the excretory ducts of the testicles and pros- tate, and may induce gonorrhceal prostatitis or orchitis ; prolifera- tions of the papillary bodies, in form of the so-called condylomata (from fcovdvXog, a button-like prominence on bone), often occur where gonorrhceal pus stagnates ; (2) the soft chancre, an ulcer, usually on the glans and prepuce, which frequentl} r , through the lymphatic ves- sels, excites an inflammation of the inguinal glands, which has a great tendency to go on to suppuration ; (3) the proper syphilitic ulcer, the indurated chancre. In this the general disease occurs at the time of inoculation, while the first and second form remain relatively local. In inoculation with the secretion of a true syphilitic ulcer, 428 CHRONIC INFLAMMATION OF THE SOFT PARTS. the entire organism is infected at once ; a series of chronic inflamma- tions occur in the most varied organs, which have at first a more pro- ductive character, but soon lead to disintegration of the infiltrated tissue and assume an ulcerative destructive character. The following symptoms may appear in syphilis : eruptions on the skin of blotches, papules, desquamations, and nodules ; ulcers in the fauces, on the lips and tongue, and about the anus ; osteoplastic and ulcerative periosti- tis and ostitis, especially on the tibia, cranial bones, sternum, etc. ; chronic inflammations of the greatest variety, usually with caseous degeneration in the testicles, liver, brain, and possibly in the lungs. The nodular circumscribed product of syphilis is called by Virchow "gummy tumor," by E. Wagner "syphiloma." Syphilis may also be inherited ; children are born with it ; the dyscrasia may be car- ried by the sperm to the ovum, or be in the ovum. It is still dis- puted whether a healthy woman who has been impregnated by a healthy man, and has become syphilitic during pregnancy, can con- vey the disease to the foetus, and whether a foetus begotten by a syphilitic man who has no ulcer on the penis can infect the healthy mother. It is also disputed by some that the venereal poison can pass through the placenta. Gonorrhoea and the soft chancre are local diseases, and are to be treated as such. Formerly soft and indurated chancres were regarded as two forms of syphilis, with many connecting links ; of late the dualistic theory seems to gain more and more supporters, although there is still much discussion on the subject. Many surgeons con- sider mercury as a specific, or as a sort of antidote, in syphilitic dys- crasia. It seems to me proved by recent observations that this is not exactly true. Constitutional syphilis, which only attacks a person once, may in the course of time be to some extent gotten rid of by the change of tissue ; hence all remedies that greatly promote the change of tissue are in a certain sense antisyphilitic. Most frequent- ly treatment by sweating or purging is resorted to ; occasionally syphilis is cured by a treatment of six weeks ; in some cases these modes of treatment must be continued with interruptions till they prove successful, and, finally, some cases are entirely incurable. Oc- casionally mercury, by inunction or internally, in various preparations, continued a long time, removes the symptoms of syphilis with sur- prising rapidity ; and hence, in cases where we desire to arrest as quickly as possible certain ulcerative forms, especially in the bones, it will maintain its value. Of late it has been much doubted if mer- cury alone can cure syphilis, and at the same time it has been shown what injury may be induced by continued use of mercurials, by a sort of chronic mercurial poisoning (hydrargyrosis). The mercurialists LOCAL TREATMENT OF CHRONIC INFLAMMATION. 429 and anti-mercurialists have disputed for a long time ; and in the last decennium it has entered new stages, without, however, having brought all physicians to a conclusion on this question. I incline to the views of the anti-mercurialists. In the course of your studies you will hear still more about this important and interesting point. Iodide of potash is generally recognized as one of the most important and efficacious remedies for syphilitic diseases of the bones and glands, while it does little good in other syphilitic diseases. LECTURE XXX. Local Treatment of Chronic Inflammation: Rest, Compression, Resorbents, Antiphlo- gistics, Derivatives, Fontanels, Setons, Moxee, the Hot Iron. It still remains, at the close of the chapter on chronic inflamma- tion, to run through the remedies that we may employ locally, and which are more or less prominent according to the case. Where we do not succeed in finding a constitutional cause for a chronic inflam- mation, we are limited to local remedies. Absolute rest of the inflamed part is necessary in all cases where there are pain and congestion. When possible, these are combined with elevation of the diseased part, by means of suspensories or pads placed beneath. This, by facilitating the return of the blood, has the effect of relieving and finally removing the venous tension, which is favored by the absolute rest, and hence is especially important in cases where venous congestion has induced or increased chronic inflammation. Compression. This is applied by wrapping the diseased part with moist or elastic bandages, plaster-dressing, strips of adhesive plaster, or even by covering with moderate weights (as in compressing swollen inguinal glands). Compression is one of the most important, and, when made to act regularly, is the most certain means of re- moving chronic inflammatory infiltrations. Massage, of which we spoke when treating of distortions, is par- ticularly serviceable for getting rid of old infiltrations; it sometimes accomplishes wonders ; but this method of treatment must be fol- lowed with great energy and perseverance. Moist warmth in the form of cataplasms, continually applied, is also very efficacious, as are also the hydropathic wraps. These are applied by dipping a cloth, folded several times, in cold water, wring- ing it out, enveloping the affected part with it, and covering with some air-tight substance, such as oil-silk, gutta-percha cloth, etc., and 430 CHRONIC INFLAMMATION OF THE SOFT PARTS. renewing this dressing every two or three hours. The skin, at first much cooled, soon becomes very warm ; then the dressing should be renewed, so that the cutaneous vessels are kept active by the change from cold to warm, and are thus placed in the best state for absorb- ing. In some cases these wraps are very useful. 23 Resolvent remedies. Fomentations with lead-water, infusion of arnica, camomile-tea, etc., have some reputation as resolvent appli- cations, which they do not, however, deserve ; they rather belong to the category of inactive domestic remedies. Mercurial salve, mercu- rial plaster, ointment of iodide of potassium, and tincture of iodine, are also absorbents which may be employed alternately in chronic inflammations. I am far from denying them any efficacy in such cases; but you must not expect too much from them. Of late, tincture of iodine, in doses of 5-10 drops, has been injected into lymphatic glands, but with very uneven effect. I pass over a series of resolvent plasters ; they do little good in this way ; their effect is partly as slight irritants to the skin, partly as protective coverings ; in some cases I order such plasters to prevent the patient from ap- plying something injurious ; mercurial plaster only has a medicinal effect when used for a long time. I may mention electricity as a discutient remedy ; its effect does not seem to be very great, but cases are reported where it has been used with advantage ; further investigations should be made on this point. Antiphlogistic remedies proper, such as ice, leeches, cups, etc., about which you will learn in the clinic, are rarely used, and are only of slight temporary benefit in chronic insidious inflammations ; but, in intercurrent acute attacks, they are just as useful as in primarily- acute inflammations. Some surgeons of the present time, especially Von Esmarch, use ice continuously in chronic torpid inflammations, and praise the result of this treatment. Derivatives. These play an extensive role in the treatment of chronic inflammations. They are so named because they are said to remove the inflammation from its location to other points where it will be less dangerous ; there are remedies by which we may induce cutane- ous inflammations of varied grades, and which have been proved by careful observers to have an excellent curative effect. The physio- logical explanation of the mode of action of these derivatives is as yet an unsolved problem. It is supposed that, from the application of these remedies near a point of chronic inflammation in a bone or joint, the blood and fluids are drawn outward to the skin. In some cases of inflammation accompanied by little energy or vascularization, the derivatives certainly have rather an opposite effect ; i. e., the new acute inflammation induced in the immediate vicinity of the chronic one LOCAL TREATMENT OF CHRONIC INFLAMMATION. 431 causes stronger fluxion to these parts, and arouses the chronic, torpid inflammation into an energetic, active state. But we shall not worry ourselves trying to discover the physiological way in which these remedies act ; this has always been a very thankless task. The fol- lowing remedies of this class are practically useful : Nitrate of silver in concentrated solutions mixed with fat, and rubbed on the skin a couple of times daily, induces a dark-brown hue, with silvery lustre in the skin, and a slow detachment of epidermis. It is one of the mildest derivatives, and is particularly suited to the joint diseases of sensitive children. Tincture of iodine, especially the strong tincture (iodine 3 jto absolute alcohol |j dissolved with ether), if applied to the skin morning and evening, induces a tolerably sharp burning pain ; if this painting be continued two or three days, the epidermis is elevated into a vesicle, occasionally all over the space where the remedy has been applied. Blistering plasters act more rapidly ; they consist of powdered cantharides (lytta vesicatoria, meloe vesicatorius) rubbed up with wax or fat, and spread on linen, leather, or oiled mus- lin. Well-made ordinary emplastrum cantharidum, in pieces as large as a franc or a dollar, is fastened on the skin, and in twenty-four hours a vesicle forms under it ; this is to be punctured, and a piece of wad- ding applied over it ; this dries on and becomes detached in three or four days, at which time the detached hard layer of the epidermis has been regenerated from the rete Malpighii. A large spanish-fly blister may be applied once, or a small one may be applied new every day ; the latter method is called vesicatoires volantes. Lastly, we may apply plasters containing only a small amount of cantharides, and only in- ducing continued redness. This is the emplastrum cantharidum per- petuum, or emplastrum euphorbii ; it is worn several days or weeks in succession. Although the favorable action of the above derivative remedies in chronic inflammation cannot be denied, I may say that particularly tincture of iodine and blisters do much more good in sub- acute inflammations, or the slight intercurrent acute attacks in chronic inflammation, than in the painless torpid forms. The remedies still left to mention are those followed by long-con- tinued suppuration, a suppuration which is kept up by artificial ex- ternal irritation, according to the will of the physician. Their use is so diminished during the last ten years that at present very few sur- geons resort to them. Tartar-emetic ointment and croton-oil. When repeatedly applied to the skin for a length of time, in about six or eight days, or in irrit- able skins earlier, both of these induce a pustular eruption, which is not unfrequently painful. When these pustules begin to show them- selves, we stop the applications and allow the pustules to heal. Con- 432 CHRONIC INFLAMMATION OF THE SOFT PARTS. siderable cicatrices not unfrequently remain ; the effect of these rem- edies is rather uncertain, so that they are not often used. By fonticulus or a fontanel (from fons, well), we mean an inten- tionally-induced wound of the skin that is kept suppurating; it may be induced in various ways. You may apply an ordinary blister- plaster, then cut the blister and daily dress the part denuded of epi- dermis with ointment of cantharides or other irritating salve. You will thus induce a suppuration that you may keep up as long as you continue this mode of dressing. Another way of making a fontanel is to incise the skin and place a number of peas in this incision, re- taining them in position by adhesive plaster. The peas swell up, and are to be daily renewed ; they irritate the wound as foreign bodies ; a simple ulcer is thus artificially induced. It is always simplest to make the fontanel with an incision, but we may burn the skin thor- oughly with any caustic, and keep the resulting wound suppurating by the introduction of peas. The seton is a small strip of linen, or an ordinary lamp- wick, which is drawn under the skin by means of a peculiar needle. The seton- needle is a moderately-broad, rather long lancet with a large eye at its lower end, to carry the seton. Setons are generally applied to the back of the neck in the following manner : with the thumb and fore- finger of the left hand you lift as large a fold of skin as possible, trans- fix it at its base with the threaded seton-needle and draw the latter through. After the seton has lain quiet a few days, and suppuration begins, pull it forward and cut off the part impregnated with pus ; re- peat this daily. Granulations form in the whole canal occupied by the seton ; these secrete quantities of pus. The seton is worn for weeks or months, and removed when we wish the suppuration to cease. Another mode of inducing continued suppuration is by making a slough in the skin by means of heat and preventing the resulting granu- lating wound from healing by irritating dressings or by introducing peas ; this may be kept up a longer or shorter time, according to the effect desired. For this purpose there are two modes of operation, by the so-called moxa and by the hot iron. Moxag are thus prepared : a wad of cotton is tied together with silk thread, then soaked in spirits, held on the skin with forceps and there burned. Various grades of burn may be induced by the longer or shorter action. There are other modes of preparing moxae, which, however, I shall not here describe, as moxae are now little used. If you wish to induce a slough in the skin, it may be most simply done by strong caustics and caustic pastes, or by the hot iron. The cautery-irons used in surgery, already mentioned among the hemostatic remedies, are thin iron rods a foot LOCAL TREATMENT OF CHRONIC INFLAMMATION. 433 long, with wooden handles, and with a button-shaped, cylindrical, or prismatic end, which is placed in a basin of hot coals till it reaches a red or white heat. With this, various grades of burns, even to charring the skin, and burns of variable size, form, and depth, may be induced, according as we desire extensive suppuration, or several dis- tinct small ulcers. It would lead me too far, and not be very comprehensible for you at present, were I here to enter into an exhaustive criticism about the choice and various gradations of the above remedies. These are things that you learn more quickly and certainly in the clinic, from the remarks on an individual case. I will only observe that the applica- tion of the more intense derivatives, such as fontanels, moxse, setons, and the hot iron, to children and susceptible, delicate persons, should be made very carefully, and had better be avoided. I scarcely ever use the hot iron as a derivative, though I sometimes employ it to destroy spongy granulations in caries, occasionally with very good effect. Almost all classes of remedies have for a time been somewhat the fashion, according to the prevailing theories, and so there was a time when moxae, the hot iron, or fontanels, were praised as universal rem- edies in every chronic inflammation. A fontanel was applied on the arm to protect the person against rheumatism, haemorrhoids, tubercu- losis, or cancer, with the idea that with the pus from the fontanel all morbid juices, the materia peccans, were thrown off from the body. In the same way, formerly, at certain seasons, purgatives, emetics, venesections, etc., were resorted to yearly. Even at present you will hear old practitioners tell gleefully how this or that patient was pre- served from a multitude of ills by the application of a fontanel. I shall not presume to criticise what may be accomplished by this treat- ment, for, as was mentioned, we are far from knowing how to meas- use its physiological effect ; but we should mistrust the action of reme- dies that are recommended against all possible diseases. 28 CHAPTER XV. ULCEUS. LECTURE XXXI. inatomy. — External Peculiarities of Ulcers ; Form and Extent, Base and Secretion, Edges, Parts around. — Local Treatment according to the Local Condition of the Ulcer ; Fungous, Callous, Putrid, Phagedenic, Sinuous Ulcers, Etiology, Contin- ued Irritation, Venous Congestion, Dyscrasial Causes. The study of ulcers naturally follows that of the chronic inflam- mations. Physicians practically agree as to what an ulcer is, and whether any given wounded surface is to be so regarded ; but, to give a short definition of it is about as difficult as it is to define any other object in medicine or natural history. To give you a proximate de- scription of it, we may say, an ulcer is a wounded surface which shows no tendency to heal. Here you see at once, that every large granulating wound with free proliferations, which halts in its progress toward cure, may also be regarded as an ulcer, and, in fact, Mush, to whom we owe our most comprehensive nomenclature of ulcers, desig- nates granulating wounds as ulcus simplex. From personal observations and examinations we conclude that ulceration mostly starts from chronic inflammation, and is always pre- ceded by cellular infiltration of the tissue. This inflammation may be located in the depth of the cutis, in the cellular tissue, muscles, glands, periosteum, or bones; in the centre of the inflamed spot there is suppuration, caseous degenera- tion, or some other form of softening and breaking down, with grad- ual peripheral progression and perforation of the skin from within outwardly. The excavated ulcer is thus formed ; as before stated, this is a diminutive cold abscess. Just as often the process is in the superficial layers of a membrane, and we have the open cutaneous ulcer. We will illustrate this by an ANATOMY OF ULCERS. 435 example. Let us suppose that from any of the above-mentioned causes we have a chronic inflammation in the skin of the leg, say on the anterior surface of its lower third. The skin is traversed by di- lated vessels, hence it is redder than normal, it is swollen, partly from serous, partly from plastic infiltration, and it is sensitive to pressure. Wandering cells are infiltrated, especially in the superficial parts of the cutis ; this renders the papillae longer and more succulent ; the development of the cells of the rete Malpighii also becomes more plentiful, its superficial layers do not pass into the normal, horny state ; the connective tissue of the papillary layer is softer and be- comes partly gelatinous. Now, slight friction at any point suffices to remove the soft, thin, horny layer of the epidermis. This exposes the cell layer of the rete Malpighii ; new irritation is set up, and the result is a suppurating surface, whose upper layer consists of wan- dering cells, the lower of greatly degenerated and enlarged cutane- ous papillae. If at this stage the part be kept at perfect rest, and protected from further irritation, the epidermis would be gradually regenerated, and the still superficial ulcer would cicatrize. But usually the slight superficial wound is too little noticed, it is exposed to new irritations of various kinds ; there are suppuration and molecu- lar destruction of the exposed inflamed tissue, then of the papillae and the result is a loss of substance which gradually grows deeper and wider ; the ulcer is fully formed. The accompanying figure is the section of a spreading ulcer of the skin ; it formed the basis of this description (Fig. 72). Fig. 72. Cutaneous ulcer of the leg. Magnified 100 diameters ; after Fdrster. Atlas, Taf. XI. At a you see the cutis already somewhat thickened, toward b its papillae are enlarged, while the vascular loops increase, and the connective tissue is more richly strewn with cells ; at b is the fully- formed ulcerated surface ; at c the epidermis is much thickened and forms the indurated border of the ulcer. 436 ULCERS. On the mucous membrane the process is the same : at first there is a lively emigration of young cells on the surface ; this is soon ac- companied by a moderate degree of serous and plastic infiltration in the connective tissue of the mucous membrane ; the mucous glands secrete plentifully. As already stated, it was believed, until within a short time, that catarrhal pus was of a purely epithelial character; now there is rather an inclination to the view that the elements of catarrhal secretion also are wandering white blood-corpuscles. Con- tinued irritation of a mucous membrane affected with catarrh is followed by softening and breaking down of the tissue, as we de- scribed to be the case in the cutis ; then we have a catarrhal ulcer. There is another and more acute mode of formation of ulcers, viz. : from pustules that do not heal, but which enlarge after evacuation of the pus, and keep up an acute inflammatory character, as the soft chancrous ulcer. And such ulcers resulting from ecthyma pustules, without any preceptible specific dyscrasia, are particularly frequent on the legs of young, full-blooded, and otherwise healthy persons ; we know nothing definite about their causes ; they often have a prolifera- ting fungous form, but at other times induce rapid destruction of tis- sue. But this acute commencement of ulcers is much rarer than the chronic. Some diseases are only half-correctly called ulcers, as the " typhous ulcer ; " in typhoid fever there is an acute progressive in- flammation of Peyer's plaques, which in many cases ends in gangrene, with necrosis of the inflamed portion of mucous membrane ; what re- mains after throwing off of the slough is a granulating surface, which usually cicatrizes rapidly ; strictly speaking, this granulating surface is not an ulcer, it only becomes so when it does not heal normally. Of this, more hereafter ; we may use these expressions more freely, when we understand the process perfectly. From this description you see that, in ulceration as in inflamma- tion^ two opposite processes are combined — new-formation and de- struction; the latter results from liquefaction of the tissues, i. e., through suppuration, or molecular disintegration, or both together. There can be no doubt of the antagonistic relations of new formation and destruction to each other in the examples adduced, for it is evi- dent that there the former preceded the latter. But you may also imagine that in a previously healthy portion of skin there might be a disturbance of nutrition of such a nature that disintegration of tis- sue is the first step, as you have already learned from the section on gangrene. Then on the border of the healthy portion of skin, which retains its vitality, there is a new formation of young cells, and, if the parts adjacent to the primarily necrosed spot be healthy, there must result a granulation surface ; but, if the parts be not healthy, and have NOMENCLATURE OF ULCERS. 437 only a slight amount of vitality, there also we shall have disintegra- tion instead of active inflammatory new formation ; an ulcer will thus be formed which will spread gradually. This course, of an ulcer occurring primarily with molecular disintegration without precedent cellular infiltration, rarely presents itself in practice. Strictly speak- ing, molecular disintegration and gangrene are but quantitative varie- ties of the same process, viz., the death of certain portions of tissue ; cases occur where ulceration and gangrene are very closely associated, as in hospital gangrene, of which we have already spoken ; but, as before said, an inflammatory infiltration usually precedes the disin- tegration. The above observations, which show the relation of ulceration on the one hand to the new formation, on the other to the gangrene, will have rendered evident the difficulty of preserving systematic divisions of the course of this disease. But do not be afraid that I am going to confuse you : we will enter at once on the special peculiarities of ulcers, you will understand then more readily ; here we shall only add that, according to the vital process, all ulcers may be divided into two chief varieties, viz., those where the new formation predominates, which we shall designate briefly as proliferating ulcers, and those where suppuration and disintegration are more prominent, which we shall call atonic or torpid ulcers. Between these two extreme boun- dary-points of the anatomical and vital peculiarities of ulcers, there are numerous intermediate forms. To induce healing of an ulcer, the first requirement is arrest of the disintegration on the surface, next that the floor of the ulcer as- sume, at least approximately, the character of a healthy granulating surface, which goes on to cicatrize in the usual way. In torpid, atonic ulcers it is also absolutely necessary that there should be a free de- velopment of vessels and stronger cells, which do not lead to sup- puration, but to connective-tissue new formation; in proliferating ulcers, on the other hand, the new formation must be brought back to the normal size. As you will readily perceive, on reflection, this gives the indication for the local treatment to be followed in either case, to which we shall soon refer. The nomenclature of ulcers varies greatly, according to the pecu- liarities that are made especially prominent. From the mode of ori- gin, just as in other chronic inflammations, we may distinguish two classes, or chief varieties, viz., idiopathic and symptomatic ulcers. Idiopathic ulcers are such as result from purely local irritation ; they may also be termed irritative ulcers. Symptomatic ulcers are such as from some dyscrasia appear as a symptom of constitutional disease, without the action of a local irritation on the affected part. This di- 438 ULCERS. vision of the causes of ulcers is, as already stated, the same that we have previously studied in chronic inflammation. Let us at present leave out of consideration these etiological con- ditions, and seek first of all, by attending to the external appearances that an ulcer may offer, to give a more perfect representation. I will only add here that ulceration may not only occur in normal tissue but also in new growths in tumors proper ; both excavated and superficial ulcers may form in and on them. In describing an ulcer, the following parts are distinguished : 1. Form and extent of the ulcer. It may be circular, crescentic, quite irregular, ring-shaped, superficial, deep ; it may be a canal, lead- ing into the deeper parts, a tubular ulcer, a fistula ; as I have already told you, these fistulae result from the formation of a point of inflam- mation in some deep parts, in a deep layer of the cutis, in the subcutaneous tissue, muscles, periosteum, or bones, or even in the glands, and gradually ulcerating through till it reaches the surface. Hence fistula is always preceded by the formation of an excavated ul- $er, of a more or less deeply-seated point of ulceration. 2. The base and secretion of the ulcer. The base may be shallow, deep, or projecting; it may be covered with dirty, badly-smelling serous, sanious fluid, or even with gangrenous tags of tissue (sanious ulcers) ; an amorphous, fatty, creamy, or smeary substance may cover it ; it may also have luxuriant granulations with a muco-purulent secretion (fungous ulcers); 3. The edges of the ulcer are flat or elevated, wall-like, hard [callous ulcers), soft, tortuous {sinuous ulcers), zigzag, everted, under- mined, etc. 4. The vicinity of the ulcer may be normal or inflamed, oedema- tous, indurated, pigmented, etc. These universally employed technical terms suffice for the de- scription of any ulcer to a scientific 'person. But, as the terms ex- pressing the vitality of the process, as torpid, atonic, proliferating, fungous, etc., are briefer, they are more frequently employed ; desig- nations referring to the ultimate causes, especially of symptomatic ulcers, are also often used. Thus we speak of scrofulous, tuberculous, syphilitic, etc., ulcers. While we have the local conditions of ulcers fresh in our memory, we shall speak of local remedies, as far as their employment depends on the condition of the ulcer. A large number of ulcers, especially of those that have resulted from repeated local irritations, heal very readily. As soon as the diseased parts are under favorable external circumstances, and not subject to new irritation, cicatrization often begins sDontaneously. It is remarkable how rapidly the common LOCAL REMEDIES. 439 ulcer of the leg begins to improve in appearance as soon as the patient has taken a warm bath, simply applied a wet compress to the ulcer, and remained in bed quietly for twenty-four hours. The ulcer, which previously looked dirty or grayish-green, and had a pestilent odor, looks quite differently ; it has a tolerably fair if not very actively gran- ulating surface, and secretes good pus ; a fortnight's rest and great cleanliness sometimes suffice for a perfect cure of small ulcers of this kind. But the patient is hardly dismissed, and in his old mode of life, before the cicatrix again opens, and, in a few days, his condition is as bad as ever. So it goes on : the patient again enters the hos- pital, and is again dismissed, to be again received in a short time We have, however, some means of protection against these relapses, of which we shall speak hereafter. All ulcers are not inclined to heal so quickly ; many require various remedies and a long treatment. We shall now run through the various forms, according to their local symptoms, and mention the local remedies to be employed. 1. The ulcer with inflamed borders, and the erethitic ulcer. Fre- quently, while the patient is constantly going about, an ulcer ap- pears very red and painful, and, after a period of rest, this slight amount of inflammation spontaneously subsides. But there are other ulcers whose borders are constantly red and sensitive, the ulcer bleeds easily, and the granulations are painful to the touch. Such ulcers are called erethitic or irritable / the highest grades of erethism of the surface of the ulcer are very rare ; in Zurich, I had a patient, who, as a sequent of a severe inflammation in the thigh, lost a large portion of skin by gangrene ; after the detachment of the eschar, there was left a very luxuriantly proliferating, granulating surface, with little tendency to heal, which was so painful to the lightest touch that the patient would cry out and shrink away. The cause of this excessive sensitiveness in such cases has already been mentioned when speaking of nerve cicatrices. In treating inflamed and erethitic ulcers, we first try mild salves of fresh butter and wax, unguentum cereum, then so-called cooling salves, such as those of zinc and lead, also fomentations with lead- water ; if under this treatment the granulations continue painful and look badly, while the inflammation of the surrounding parts is less, we may cauterize the surface of the ulcer freely with nitrate of silver, or, still better, with the hot iron ; the latter remedy, with subsequent compression by adhesive plaster, finally caused healing in the case above mentioned. In such cases, the local employment of narcotics is usually recommended, such as cataplasms, with the addition of bel- ladonna, hyoscyamus, opium, etc., but these remedies do so very little good, that, in my opinion, their employment is only time lost. 440 ULCERS. 2. Fungous ulcers, i. e., those whose granulations are fungous and proliferating, and project above the level of the skin. These ulcers secrete a muco-pus, and are very vascular. Fig. 73. $Mm^m Blood-vessels of two luxuriant granulations of a common (not cancerous) ulcer of the leg, arti- ficially injected by Thiersch (Epithelial cancer, Plate XI., Fig. 4). In these cases we may use astringent remedies and compresses wet with decoction of Peruvian or oak bark, but they are of only moderate benefit. It is best to destroy the surface of such granulations by caus- tics; daily applications of the solid stick of nitrate of silver usually suffices, where it does not, we may resort to caustic potash or the hot iron. Compression with adhesive plaster is often very efficacious. 3. Callous ulcers are most dreaded by surgeons, on account of the long treatment they require ; they are those whose base, edges, and vicinity, have become thickened and of cartilaginous hardness, from the long duration of chronic inflammation. The ulcer is torpid, and usually lies deep below the surface; the edges are sharply bounded. The indications for treatment are twofold : first, to soften the tendinous, non-vascular tissue of the hardened borders and base of the ulcer ; and to induce a proper amount of vascularity in these parts. We meet ulcers of this variety that have lasted twenty years or more ; in such cases we may employ the following treat- ment : compression, best with strips of adhesive plaster applied in a certain way, as you will see done in the clinic. This dressing, which should cover not only the ulcer but the entire leg, may at first be left on a day or two, but later, when the ulcer begins to heal, it may re- main untouched for three or four days, or longer. This so-called CALLOUS ULCERS. 441 Baynton dressing of adhesive plaster is of great service in ulcers oi the leg, especially for those cases where the patients are not inclined to lie still, but must attend to their business. In the surgical poli- clinic of Berlin I made some observations on this treatment of ulcers of the leg, but cannot report so favorably on it, as a means of cure, as has been done by other surgeons — they seem to claim that this dressing is an almost universal remedy in ulcers of the leg. I prize it greatly as a protective dressing in dispensary practice, because it enables the patient to go about, without the ulcer spreading ; but I cannot see that all ulcers heal particularly well under this dressing, or that the action of the adhesive plaster on the callous borders of the ulcer is more effective than the remedies which I shall mention after a while. The best remedy for keeping up constant congestion in the ulcer, and thus increasing the formation of vessels and cells, is moist warmth, which you may use in the form of cataplasms, or, still better, as a continued warm-water bath. I would particularly recommend the latter to you, for by it you at the same time obtain an artificial swelling and softening of the dry, hardened borders of the ulcer. Zeis, who has often employed the warm-water bath in callous ulcers of the leg, also recommends this treatment as one of the most effi- cacious in such cases. It is sometimes very important to destroy the callous edges entirely, or to excite in them a high degree of purulent inflammation. The former you may most quickly accomplish by the hot iron, the latter by repeated application of tartar-emetic ointment or emplastrum cantharidis. If a pustulous or even gangrenous inflam- mation of the ulcer and its vicinity be induced by the latter reme- dies, place the foot in a water-bath and you will often obtain a very quick cure. It is not always possible to obtain healing of a callous ulcer of the leg ; and ulcers along the anterior face of the leg, extending to the periosteum of the tibia, are especially intractable ; those ulcers also which surround the leg like a ring are usually reckoned as incurable ; they are considered as indications for amputation when they perma- nently prevent the patient from walking or attending to his business. Besides the above-mentioned circumstances there is still another, that impedes the healing of ulcers with greatly-indurated borders, that is that the healing granulating surface and cicatrix do not diminish and thicken by contraction, because the firmness of the surrounding por- tions of skin permits no displacement ; while, as you know, all granu- lating wounds decrease to about half their size by contraction, and hence the cicatizing surface grows smaller, in many cases the granu- lating surface of these ulcers must cicatrize throughout its entire ori- ginal extent, because it cannot contract. To render this contraction 442 ULCERS. possible, deep incisions have been made through the skin around the ulcer, and these incisions have been kept open by the introduction of charpie ; I have never seen any great benefit from this treatment. As a consequence of the rigidity also, the new cicatrix is not suffi- ciently dense and readily reopens, so that the ulcer once healed soon develops again. To guard against this it is best to cover the cicatrix with wadding and apply a starch-bandage. This dressing should be worn six or eight weeks, till the cicatrix is firm and well organized. I have followed this practice for a long time in all cases of ulcer of the leg, and have every reason to be satisfied with it. 4. Suppurating ulcers. The causes of decomposition taking place on the surface of an ulcer are often due to unfavorable ex- ternal circumstances ; but, in other cases, from constitutional causes, there is a tendency to more rapid disintegration of the tissue on the surface of the ulcer. Solution of chloride of lime, pyroligneous acid, turpentine, spirits of camphor, and carbolic acid, are the remedies to be applied in such cases. If the destruction of the tissue go on very rapidly, so that the ulcer enlarges greatly from one day to another, it is called an eating or phagedenic ulcer ; this form closely resembles hospital-gangrene above mentioned. In some cases sprinkling pow- dered red precipitate of mercury quickly arrests the disintegration ; should it not do so, I would advise not to postpone the destruction of the entire ulcer ; free cauterization with caustic potash or the hot iron, destroying the edges of the ulcer down to the healthy tissue, almost always proves effective in these cases. 5. Sinuous and fistulous ulcers — ulcers with excavated edges and fistulas. They always begin as abscesses, which gradually break through from within outward, and are particularly apt to depend on chronic suppuration of lymphatic glands. Such an ulcer will always heal more rapidly if you make an open ulcer of it, by cutting away the edges of skin, which are usually thin and undermined, or, if they are too thick for you to do this, at least split up the cavity and expose the deeply-seated ulcer. This treatment also answers for fistulous ulcers when they lead to abscesses ; the latter must heal before the fistula can close firmly. Let me remark, in parenthesis, the word " fistula " has still another meaning, as it is applied to any tube-like abnormal opening that leads to any cavity of the body ; thus we speak of breast, brain, gall-bladder, intestinal, vaginal, urinary, ure- thral, and other fistulas. We have still to consider a very important part of the chapter on ulcers, viz., the etiology, I have already told you that we have to distinguish local and constitutional causes, just as in chronic infiam- CAUSES OF ULCERS. 443 mation. Hence all the causes that induce chronic inflammation are again to be enumerated here ; we will call particular attention to a few of these. If we first consider more carefully the local causes of ulcers, the most important of them is continued mechanical or chemi- cal local irritation. Continued friction and irritation are frequent causes of such irritable ulcers ; a tight boot, the hard edge of a shoe, may induce ulcers on the feet ; a rough tooth or a sharp piece of tar- tar may cause ulcers of the mucous membrane of the mouth or tongue, etc. Ulcers of this variety usually bear the marks of irritation ; the vicinity is red and painful, as is the ulcer itself. Among the chemical irritants we have the action of schnaps and rum on the gastric mucous membrane ; as a rule, topers have constant gastric catarrh, during whose course catarrhal and specific ulcers, of various kinds, not unfre- quently form. A second and still more frequent cause of chronic inflammation, resulting in ulceration, is congestion, especially venous congestion, distention of the veins, varicose veins. These are very intimately connected with the origin of ulcers of the leg; we shall speak of them later (Chapter XIX). There we will only mention that, as a result of the continued distention of the small cutaneous veins, there is chronic serous infiltration of the skin, to which is gradually added cellular infiltration, thickening ; and, lastly, there are frequently suppuration and disintegration. Ulcers due to varices, which are generally briefly termed varicose ulcers, may have very varied characteristics. At first they are ordi- narily simple, often proliferating ulcers ; subsequently they assume a more torpid character, and then the borders become callous. We have already noticed how quickly such ulcers change when they are only treated by rest and cleanliness. In regard to treatment, the already- lauded dressings with adhesive plaster are excellent both for inducing healing of the ulcer and arresting further development of the varices. But in most cases I prefer rest in bed, on the principles above given, and only subsequently apply the adhesive plaster to prevent further increase of the varices. Although we have here shown the intimate relations between varicose veins and ulcers, and have thus called attention to the point of greatest practical importance about this disease of the veins, you must not conclude that varices are always followed by ulceration ; on the contrary, there are many cases of enormous varices that are not followed by secondary ulcers. We come now to a short description of those ulcers that are due to internal causes, and are connected with various dyscrasia — the symptomatic ulcers. 444 ULCERS. 1. First among these are scrofulous ulcers ; these most frequently come m the neck, enclosed collections of pus developing in the cutis or subcutaneous tissue, and gradually perforating out through the skin. Of course, this causes small losses of skin, whose edges are usually red and very thin, and which lead to deeply-seated cavities that evacuate thin pus or tissue that has undergone caseous degen- eratiou. The borders of these cutaneous ulcers are excavated, as may readily be shown by examining with the probe. As a rule, these are typical atonic ulcers. From this description you see that this form of undermined sinuous ulcers is only due to the mode of origin, and may occasionally present itself under the most varied constitutional con- ditions ; although experience teaches that it is especially frequent in scrofulous persons, and this is why such atonic ulcers with under- mined edges are referred to scrofula. This conclusion will generally prove correct, though it is not necessarily the case. 2. Lupous ulcers. By lupus we understand a disease which manifests itself by the development of small nodules in the superficial layer of the skin. The subsequent progress of these nodules may vary. They consist of collections of wandering cells and coincident ectasia of the vessels. Lupous nodules may (a) enlarge and run together, so as to form larger nodules and tuberculous thickenings of the skin (Lupus hypertrophicus) ; (b) on their surface there is a free exfoliation of epidermis (Lupus exfoliatus) / (c) the surface ulcerates (Lupus exulcerans). All three forms may combine, and some others may be added to them. The ulcers resulting from the latter form may be accompanied by strongly proliferating granulations (Lupus exul- cerans fungosus), or dispose to a more rapid destruction of tissue (Lupus exedens, vorax). The disease is most frequent on the face, especially on the nose, cheeks, and lips ; it causes the most frightful disfigurement. The nose or the lips may be entirely destroyed by lupus. I saw one case where all the skin of the face, nose, lips, and eyelids, was destroyed ; both eyes had been lost by suppuration, and the facial part of the skull, being exposed, presented a most horrible sight. Lieffenbach describes such a case in a Polish count, and com- pares his appearance to that of a death's head. Lupous ulcers do not by any means always look alike ; but their surroundings, and the general appearance of the portion of skin diseased, greatly facilitate the diagnosis. When lupus occurs in other parts of the body, as in the extremities or mucous membranes, as the throat or conjunctiva, the diagnosis is difficult, and cannot always be made positively. It is not only pardonable, but sometimes unavoidable, to mistake the disease on the extremities for certain forms of leprosy, and in the throat for syphilitic ulcers. In most cases lupus is due to a dyscrasia. It is LUPUS. 445 rarely a purely local skin-disease. It is doubtful whether we are jus- tified in claiming a particular lupous dyscrasia, for lupus very often attacks scrofulous persons, so that it may be regarded as one, and one of the worst symptoms of scrofula. It also comes as one symptom of syphilis, so that lupus syphiliticus and lupus scrofulosus are spoken of. Lupus is most frequent during puberty, and attacks females oftener than males ; it more rarely develops late in life ; beyond the fortieth year we are pretty safe from it. In the way of treatment I attach most importance to local treat- ment, especially in the ulcerative form, for here we must make every attempt to arrest the progress of destruction, which may endanger all the skin of the face, and internal remedies act very slowly. Here, as in all rapidly-spreading ulcerations, we should radically destroy the base and edges of the ulcer by cauterizing down to the healthy tis- sue. We generally employ the potential cautery and the solid stick of nitrate of silver or caustic potash, pushing them through the lupus into the healthy parts below. We may also use the caustic in the form of paste, such as chloride-of-zinc paste, which is most readily made by mixing chloride of zinc with rye or wheat flour, and making it into paste with a few drops of water, then spreading it on the ulcer. To attain our object more rapidly, and let the caustic act more in- tensely, it is advisable to scratch up the floor of the ulcer with the flat end of a probe, and, after arresting the bleeding, apply the caus- tic. Of the remedies above mentioned, I prefer caustic potash, as it unites with the tissues most rapidly, and consequently the pain ceases sooner. This cauterization may be done during anaesthesia, so that when the patient awakes there will be a moderate and tolerable burn- ing. Nitrate of silver causes the most protracted suffering, but has the advantage of liquefying less rapidly than caustic potash, and hence possesses special advantages for cauterizing some portions of the body. When the slough from the cauterization is detached, if the operation was thoroughly done, there is left a good granulating sur- face, which cicatrizes in the ordinary manner. A new lupus is not apt to form in this cicatrix, although cauterization cannot prevent the development of new nodules in the vicinity. Painting with tincture of iodine is the best local remedy in exfoliative and hypertrophic lupus. It is well to mix this remedy with glycerine, to render its ac- tion less intense. I have repeatedly seen lupus nodules shrivel up under this treatment, but it does not prevent relapses. Lastly, in some cases, the portion of lupous skin may be excised with advan- tage. The only internal remedy from which I have seen benefit is cod-liver oil, of which four to six table-spoonfuls are to be given daily, but this treatment must be continued for years. Decoctions of barks 446 ULCERS. are only useful in lupus syphiliticus. Arsenic, which is highly prized in other chronic skin-diseases, is of little use in lupus. In Switzer- land the disease was rare. My experience of it was chiefly derived in the Berlin clinic, and, if I were to state my belief regarding the effi- cacy of internal treatment, it would be to the effect that the lupous dyscrasia, like the scrofulous, often disappears spontaneously in the course of time, but is also often incurable. 3. Scorbutic ulcers. Scorbutus, or scurvy, is a disease which, as al- ready stated, when fully developed, manifests itself by great weakness of the capillary vessels. There are extravasations of blood at many places in the skin and muscles ; the gums swell, become bluish red, and ulcers, which bleed readily, form on them ; there are also intes- tinal haemorrhages, general emaciation and debility, and many patients die in a miserable state. This severe form of scorbutus occurs chiefly endemically on the coasts of the Baltic, and in sailors on long voy- ages. In the latter case the disease is usually referred to continued use of salt meat. Inland there is a sort of acute scorbutus, comprising morbus maculosus, purpura, etc. Scorbutus localized on the gums and oral mucous membrane is everywhere common among children ; the gums swell, become of a dark bluish red, bleed on the least touch, and ulcers, covered with a yellow, smeary coating of pus, fungi, and shreds of tissue, form on them. When the disease appears in this form, and is treated early, it is generally readily cured. You should paint the gums twice daily with a mixture of half a drachm to one drachm of muriatic acid and an ounce of honey ; internally administer mineral acids in dose and form suited to the age, and order a light, easily-digested diet. If this treatment be conscientiously followed, the disease soon disappears. General endemic scorbutus is difficult to cure, because it is generally impossible to withdraw the patients from the injurious endemic influences. In this also the acid treatment is greatly recommended. 4. Syphilitic ulcers. The marks that are usually given, as particu- larly characteristic of syphilitic ulcers, refer almost exclusively to the primary chancre, especially the soft chancre. This begins as a ves- icle or pustule, develops to an ulcer as large as a pea, with red bor- ders and a yellow, fatty-looking base. The ulcer of the indurated chancre looks differently; in this there is first a nodule in the mem- brane of the glans or prepuce. This nodule ulcerates from the sur- face, as other cutaneous ulcers do. It usually assumes an atonic, torpid character, frequently with a marked tendency to breaking down of the tissue. Broad condylomata, one of the milder evidences of constitutional syphilis, are, strictly speaking, nothing but small, su- perficial, very circumscribed fungous cutaneous ulcers, which occur SYPHILITIC ULCERS. 447 most frequently on the perinaaum, about the anus, and on the tongue. The so-called tertiary syphilitic ulcers of the skin often have very in- durated, brownish-red borders, are circular, or horseshoe-shaped, and are also atoDic in character. You will see from this that the appear- ance of syphilitic ulcers also may vary greatly, and hence that the mere appearance of the ulcer does not enable us to judge with cer- tainty of the presence of constitutional syphilis. The treatment of true syphilitic ulcers should be chiefly internal, and be directed against the constitutional disease. Locally we should use intense caustics if the destruction of tissue is going on rapidly. Older surgeons also distinguished numerous forms of ulcers that have not been mentioned here, and that were said to be characteristic of the causes. For instance, in his treatise on ulcers (Helkologie) Must speaks of rheumatic, arthritic, haemorrhoidal, menstrual, abdom- inal, herpetic, etc., ulcers. But I, in common with other surgeons of modern times, have been unable to penetrate into the mysteries of this exact diagnosis. It is now generally considered that the old no- menclature was based rather on an artificial system originating in the old humoral pathology than on critically exact observation. From unprejudiced observation we should unquestionably acknowledge that certain forms of ulcers, particularly when affecting certain localities, enable us to decide on their cause ; nevertheless, the appearance and form of the ulcer are very dependent on the anatomical relations of the part affected (e. g., as by the course of the filaments in the skin, Wertheim), and on various external causes, so that we should fre- quently be deceived if we relied too much on the appearance of the ulcer as an unmistakable expression of a specific constitutional cause. CHAPTER XYI. CHRONIC INFLAMMATION OF THE PERIOSTEUM, OF THE BONE, AND NECROSIS. LECTURE XXXII. Chronic Periostitis and Caries Superficialis. — Symptoms. — Osteophytes. — Osteoplastic, Suppurative Forms. — Anatomy of Caries. — Etiology. — Diagnosis. — Combination of Various Forms. Geistlemen" : Chronic inflammations of the bones and periosteum, to which we now pass, are far more frequent than the acute forms ; the more common disease is chronic periostitis, which is often accom- panied by ostitis (caries) superficialis. In the early stages this may end in resolution, then go on to suppuration, with ulceration of the surface of the bone ; it may also be accompanied by a deposit of newly-formed ossific substance on the surface of the bone. Perios- titis that has lasted some time will never leave the bone unaffected. Let us first consider the symptoms of chronic periostitis. The first symptoms are usually slight pain, and moderate swelling of the parts immediately around the affected bone. These are accompanied by slight functional disturbances, especially when the disease is in one of the extremities. Spontaneous pain is usually slight, or may even be entirely wanting. Pressure induces severe pain, and we find that the impress of the finger remains evident on the skin for some time, showing that the swelling of the skin is chiefly cedematous. The dis- ease may remain for a long time in this stage, and may subside as gradually as it began. In such cases you may consider the affection as located in the external loose connective tissue of the periosteum. Here there is distention of the vessels, serous and plastic infiltration. The symptoms above given may also depend on a periostitis com- bined with a superficial ostitis, only in the latter case the spontaneous pains are occasionally more intense ; there are also severe, boring, PERIOSTITIS. 449 tearing pains at night. If such a process has lasted for months and then recedes, the affected bone remains thickened and nodular on the surface. If you have a chance to examine such a case anatomically, you find the following : The two layers of the periosteum cannot be exactly separated ; both have changed to a fatty-looking, tolerably- consistent mass. On microscopical examination you find that the tis- sue consists of connective tissue richly strewn with cells and traversed by dilated capillaries in greater or less number. This morbidly-thick- ened periosteum is more readily detached from the surface of the bone than is normally the case ; the subjacent bone (we are supposing a hollow bone, such as the tibia) has its surface covered with small nodules of peculiar, occasionally stalactite shape. If you now saw through the bone, you find that these nodules on the still-distinct sur- face of the compact cortical substance are a thick layer of porous, apparently young, newly-formed bone-substance, which are very inti- mately connected with the cortical substance, it is true, but which, nevertheless, if the process be not too old, may be broken off with a chisel in good-sized pieces. If the disease has already lasted some time, and the union has become very intimate, we find that the de- posited porous bone has become more compact, especially if the mor- bid process has actually terminated. Let us stop here a moment to inquire the origin of this newly- formed bone. It may come either from the inner surface of the periosteum, or from the surface of the bone. The former is the gen- erally-received opinion, and it is supposed to be a renewal of the function of the periosteum, as it existed before the bone had com- pleted its growth, when regular layers of new bone were always formed on the inner surface of the periosteum. This form of perios- titis, which is combined with the formation of osteophytes (as the young bony substance deposited during inflammation is termed), may be called osteoplastic, a name which I shall use, for the sake of brevity. Nevertheless, I do not agree in the above view, that osteophytes pro- ceed solely from the periosteum, but am satisfied that they actually grow from the bone, as the Greek name indicates. For, microscopic examination shows that, in this case also, as in suppuration and gran- ulation on the surface of the bone, the small vessels that enter and escape from the bone with their enveloping connective tissue are the seat of the new formation, which advances from the Haversian canals opening on the surface of the bone, and are the point of origin for the new formation of bone, which then spreads out under the perios- teum. These ossifying granulation-nodules grow from within out- ward somewhat into the periosteum, and then the latter takes a secondary part in the process, as it seems to me. The form of the 29 450 CHRONIC INFLAMMATION OF THE PERIOSTEUM, BONE, ETC. osteophytes, which is often peculiar, depends on the arrangement of the vessels around which the young osseous material is deposited. We would not by any means assail the undoubted fact that the peri- osteum, and other parts adjacent to the bone, may also produce new bone, still I assert that, correctly viewed, osteoplastic periostitis is an osteoplastic ostitis superficialis. This subtle distinction has no prac- tical value, so far as we now know. Osteophytes are the product of an inflammatorg irritation of the periosteum and surface of the bone ; they are precisely what we call callus, in fractures, and they are formed in the same way. I here remark that periostitis, accom- panied only by formation of osteophytes, without any suppuration, is especially peculiar to some forms of constitutional syphilis. The dolores osteocopi, which may be so torturing in the head and shin- bones, in tertiary syphilis, are almost always due to osteoplastic periostitis and ostitis. According to my experience, almost every chronic periostitis is at first osteoplastic ; all other terminations follow it more or less closely. The suppurative form is also very frequent ; it may run its course without the bone being much affected. Recall the symptoms already mentioned : cedematous swelling of the skin, pain on deep pressure, and a slight amount of it on moving the limb. This condition re- mains long the same, but is gradually followed by more swelling, by an immovable, doughy tumor, not perfectly but still tolerably well defined. By degrees the skin reddens, and the tumor fluctuates de- cidedly. Four to six months may thus pass, and then the tumor remains for a long time unchanged. The pain has probably increased, and the function is more disturbed. If the disease be left to itself, the cold abscess, which now evidently exists, will open, and a thin pus mixed with flocculi or cheesy substance will escape. If, through the fine opening, you pass a probe, it will enter a cavity lined with gran- ulations. If you do not wait for the spontaneous opening of the abscess, but make an incision through the thin skin, it is possible that no pus may escape, but that you will find the fluctuating tumor to consist of a gelatinous mass of red granulations ; in other cases there is some pus in the centre of the swelling ; in still others the entire tumor is of pus. From what I have already told you of the anatom- ical conditions in chronic inflammation, you will readily understand these different states. If, in the periosteum, infiltrated with serum and plasm, you imagine a rich development of vessels, and at the same time an infiltration of wandering cells, and transformation of the connective tissue to a gelatinous intercellular substance, the former is metamorphosed to a spongy mass of granulations. This may sooner or later change to pus, and an abscess is the final result. If the whole PERIOSTITIS. 451 Fig. 74. process affects only the periosteum and superjacent soft parts, the bone is but little changed ; some inclination to new formation is ex- hibited on its surface by the production of a layer of osteophytes under and in the periphery of the part affected with periostitis. Nevertheless, there is a possibility of the abscess healing slow- ly, after the pus has been evacuated, and of a return to the previous normal state. Such a recovery of periostitis, without implication of the bone, occa- sionally occurs in practice, but it is rare. It is far more common for the bone to be also affected, perhaps only super- ficially; that is, for periostitis to be accompanied by ostitis ; not an ossify- ing, but a chronic, suppurative, ulcer- ative ostitis — a caries superficialis. Before the abscess has opened, the symptoms of such a caries scarcely dif- fer from those of suppurative perios- titis. If the abscess has opened, we may pass a probe into the surface of the bone, which we feel to be rough and gnawed. The caries had existed some time, and was secretly eating into the bone before the abscess opened; it probably existed when the perios- teum only appeared infiltrated, and was still in the stage of gelatinous granulation. Hence, suppuration is not necessarily combined with caries, although it frequently accompanies it. To make all this clear to us, we must study chronic ostitis by means of prep- arations. The whole development and course are quite analogous to the course of chronic inflammation in the soft parts, but the hardness and difficult solubility of bone give rise to somewhat different circum- stances. Caries superflcialis of tne tibia, accord- ing to Follin. In the course of these lectures we have repeated time and time again that inflammatory neoplasia is developed in and from the affected tissue ; that the close connective-tissue filaments, by rich in- 452 CHRONIC INFLAMMATION OF THE PERIOSTEUM, BONE, ETC. Hltration of cells, are transformed into gelatinous or even fluid inter- cellular substance. Now, how shall this be transformed into bone ? The cells embedded in the stellate bone-corpuscles participate no more in the inflammatory new formation than the stable connective-tissue corpuscles. Here also, as in most tissues of the body, the inflamma- tory neoplasia infiltrates the connective tissue ; namely, that which envelops the vessels in the Haversian canals, and in the medulla of the bone. Still, the space for the extensive production of cells is limited, and, if the wandering of the cells went on very rapidly, the vessel would soon be entirely compressed in the bony canal ; if the circula- tion be then arrested, the nutrition of the young brood of cells also ceases, and the necessary result is death of the affected portion of bone (necrosis). Quite right, this may be the course ; superficial ne- crosis may thus combine with periostitis ; of this hereafter. Usually, however, the cell infiltration in the Haversian canals is not so rapid as to compress the vessels. The process is chronic ; the bone gradually gives way, the Haversian canals become wider and wider, the firm cortical substance of the bone becomes porous, in the canals (widened to meshes) lies the brood of young cells, interspersed with gelatinous intercellular substance and numerous vessels, an interstitial prolifera- tion of granulations. If you imagine the process as continuing, the bone disappears more and more, the entire infiltrated portion may be dissolved, and the inflammatory neoplasm takes its place. If you macerate such a bone, at the seat of disease you will find a loss of substance, with rough porous walls, that look as if gnawed off; in this defect lies the neoplasia that has taken the place of the bone (Fig. 74). Now, remember that so far the word pus has not been men- tioned ; still, of course, the inflammatory neoplasia may subsequently suppurate, and, if we continue our supposition that the process began in the periosteum, you have a superficial cold abscess lying on the bone ; its walls may be covered with granulations. If you have carefully followed me thus far, you will have remarked already that throughout the whole process the bone substance remains entirely passive ; it is entirely consumed, and we might say, with a certain amount of truth, chronic ostitis, or caries, is actually only a chronic inflammation of the connective tissue in the bone, with con- sumption of the latter. And according to my view this is perfectly correct, at least for the great majority of cases. Still, how does this consumption of bone take place ? Should not microscopical examina- tion show whether the bone-cells are changed or not during the pro- cess ? Remove with the forceps a particle of bone, as thin a sheet as possible, from a carious spot, and look at it under the microscope, you will in many cases see its edges and surface bitten out, as it were ; CARIES. 453 the bone-corpuscles are unchanged ; the intercellular substance some- what more cloudy than usual, perhaps, but not much altered ; a sec- tion of bone, taken from the vicinity of such a carious spot, shows nothing different. If you saw or cut out a piece from a carious spot, and abstract the chalky salts from the bone by chromic acid, and then make sections through it and clear them with glycerine, you will have about the following picture (Fig. 75) ; Fig. 75. Section of a piece of carious 'Done (caries fungosa). Magnified 350 diameters. These pieces of bone are often bitten out, as it were, quite regu- larly along their edges, the young neoplasia grows into these defects, their further increase goes hand in hand with the dissolution of the bone ; the bone-corpuscles are unchanged, no destruction starts from them, we occasionally see them half destroyed at the edge of a piece of the bone. What becomes of the cells that were in them, we can hardly say ; they can no longer be recognized among the numerous young cells of' the inflammatory new formation among which they enter ; it is possible that, freed from their cage, they aid in increasing the cell-brood by subdividing, possibly they die ; at all events, as far as may be judged by the change of form, they do not aid in dissolving 454 CHRONIC INFLAMMATION OF THE PERIOSTEUM, BONE, ETC. the bone. But how the bone is dissolved remains an unsolved riddle. Living, like dead bone, may, to a certain extent, be dissolved by the interstitial bony granulation. Previously, when speaking of operating for pseudarthrosis by the insertion of ivory pegs, I told you, if you will remember (p. 229), that the ivory pegs became rough on their surface, carious ; there the process is just the same, and this observa- tion is exceedingly interesting and important as a proof that the bone itself does not necessarily have any thing to do with its solution in caries, but may play a perfectly passive part. To anticipate the charge that I admit only this variety of consumption of bone, where the above changes occur on the surface, I must add that I have already called attention to the fact that the ivory pegs introduced for pseudarthrosis do not always become rough on the surface, but might remain smooth and still lose substance, as may be shown by weighing them before and after the operation. The morphological appearances in the carious bone, which JR. Vblkmann very aptly designates lacunar corrosions, and which Howship first made known, are now generally recognized as correct, although different views were formerly held regarding them, which you may find in the cellular pathology of Virchow, and in Forstefs atlas, if the subject interests you. One point, however, we must consider. It would be very sup- posable that the bone-substance, having its nutrition affected, would begin to break up and crumble into very fine particles, or powder ; this would be especially apt to occur if the bone had previously lost its organic substance. It could even be shown that this is the primary step in ulceration of the bone, or caries, and those who regard destruc- tion of tissue as the primary step in ulcers of the soft parts, and in- flammatory new formation as the second, will also hold this view in regard to bone. As I have already stated, my observations speak very decidedly against the universality of this view of ulceration, and what I did not find proven as regards the soft parts, I cannot consider true as regards the bones. But there is no doubt that portions of bone may crumble off, and, when there is suppurative ostitis, these small particles of bone may be found in the pus. This would be a necrosis of the lowest form ; such a death of the particles of tissue also occurs in the soft parts, both in acute and chronic inflammation ; you will doubtless bear in mind that we have spoken of this subject. It cannot be considered as a rule in caries ; it is only seen occasionally in caries with suppuration or caseous degeneration. Here even large portions of bone may become actually necrosed, and for this combi- nation of caries and necrosis we have the curious name of caries necrotica. Thus far we have used the term caries as exactly synonymous with CARIES. 455 chronic ostitis and solution of bone, and at present this is very gener- ally done ; but formerly the name caries was only used for ulceration accompanied by suppuration, for open ulcers of the bones. The inti- mate connection between chronic inflammation and ulceration, which we previously studied in the soft parts, also exists between chronic ostitis and caries. If you desire to designate the character of the inflammation more specifically, it may be done conveniently by certain additions which you already know from the chapter on ulcers. Per- haps it would be better to gradually drop the name caries and replace it by ostitis with various additions, such as rarefying, osteoplastic, ulcerating, granular, etc., or only to employ caries for bony defects caused by lacunar erosions. On macerated bones this is always readi- ly recognized ; there we are never in doubt as to whether the bone is carious, for we call carious all defects that look as if gnawed out ; they might very well be termed lacunar or corrosive defects. But on living patients it requires accurate knowledge and rich experience to decide certainly whether a bone which a sound enters readily is only softened or has large lacunar defects. Up to this point we have only studied superficial caries ; hereafter we shall come to central caries, which holds, the same relation to the superficial that the ab- scess does to an open ulcer. In the soft parts I showed you the de- velopment of the process of ulceration in a fungous ulcer, where the productive character predominates. This has its analogy in bone, in ostitis fungosa (by caries sicca, Virchow and Vblkmann mean caries with proliferating granulations and destruction of bone without sup- puration), where there is as yet no destruction of the inflammatorj' new formation, but where interstitial granulation-tissue has grown all through the bone. This does not by any means always occur to the extent we have just supposed. If you bear in mind the atonic, torpid ulcer of the soft parts, and remember how the neoplasia rapid- ly breaks down into pus, undergoes caseous transformation, or disin- tegrates, and simply apply the same changes to bone, you will readi- ly understand the case ; this also gives caries another character ; there are very torpid, atonic forms of caries where the neoplasia causes but little destruction of bone, and then disintegrates or under- goes caseous metamorphosis, and thus in the living organism there is a sort of maceration of the diseased bone ; the soft parts in the bone suppurate; if this happen before the bone is dissolved, the portion of bone that has suppurated is necrosed. Here, also, most of the fault of the disintegration is due to deficient vascularity. But we must look to constitutional influences for the causes why we have in one case fungous or proliferating, in another atonic caries. We shall become acquainted with other forms of ostitis when we come to speak of primary chronic inflammation in bones. 456 CHRONIC INFLAMMATION OF THE PERIOSTEUM, BONE, ETC. Chronic inflammation of the periosteum and bone is chiefly due to constitutional, dyscrasial diseases ; and although injuries, blows, falls, etc., may be exciting causes of these diseases, the ultimate cause must lie in the injured part or the system at large, otherwise the process would take the course usual to traumatic inflammations and soon terminate. If an injury induces insidious chronic inflam- mation, this must be due either to a peculiar local or constitutional condition ; so far I have had no reason to abandon this opinion. Of the dyscrasise already known to you, the scrofulous and syph- ilitic especially predispose to chronic periostitis and ostitis ; among scrofulous children the fungous forms of caries are most frequent, while among adults the atonic occurs oftener. True tubercles are also found in bone, but, so far as I know, not in the periosteum or the cortical layer of the long bones. But chronic periostitis also occurs frequently when none of the above dyscrasiae are discoverable, and where we can recognize no cause ; in old people especially, periostitis with caries sometimes comes from very slight injuries, and runs its course in the most dis- agreeable torpid form. The inflammatory neoplasia in the bone will greatly sympathize if the general health fails ; in children who have died of caries, you will almost always find the atonic form, for, just previous to death, while the nutrition was bad, the neoplasia also broke down ; the dis- eased bone, even during life, was macerated by suppuration and mortification. Pathological anatomists, who only see caries on the dissecting-table, rarely know the fungous form accurately, or con- sider it the more rare ; but, when one often examines pieces of carious bone, cut out during life, especially the resected joints of children, where the process is going on actively, he learns to judge differently from what he would in the anatomical museums, where macerated bones, almost exclusively, are preserved. Although I have merely spoken of fungous and atonic caries, you still understand that I have only depicted the extremes of the proliferating and rapidly disintegrating new formation. Of course, there are many intermediate forms. It is not the object of these lectures to carefully delineate all the shades of this process, as will be done in the clinic, but here the pic- ture of diseases should be drawn from typical cases, you should ac- quire a mental mastery of the subject ; hence I only lead you so far into the details of the process as is necessary for understanding its anatomy. Now you will very justly ask, How shall we know whether the case, which we have only diagnosed with the probe, be of the pro- CAKIES. 457 liferating or torpid variety ? This will have an influence on the treatment, as it has in case of ulcers of the soft parts. And it is im- portant not only for the treatment, but for the prognosis ; for pure torpid caries offers far poorer chances than the fungous form, be- cause it is far more apt to occur in poor, badly-nourished, and old persons. The distinction is not difficult. In the more proliferating forms, the swelling of the soft parts, periosteum, and skin, and espe- cially of the articular capsule when the caries affects the articular ends of the bone, is often considerable ; all these parts feel spongy. If there be any openings in the skin, proliferating granulations pro- ject from them, and a mucous, tough, synovia-like pus escapes. If you examine with the probe, you do not come at once on bare bone, but must push the probe into the granulations, often to some depth, before entering the rotten bone. In the pure atonic form there is less swelling, the skin is thin, red, and often undermined. The edges of the opening are sharp, as if cut out with a punch ; there is a discharge of thin, serous, some- times badly-smelling or sanious pus ; if you introduce the probe, you come at once on the bare, rough bone, from which the soft parts have already been separated by suppuration and maceration. These are the extreme cases of the series ; there are various intermediate forms. Taking all things into consideration, I think you will now have a correct idea of caries superficialis. Let us make a short review of what we know of chronic diseases of the periosteum and bone. We have considered chronic osteo- plastic periostitis (with formation of osteophytes without suppura- tion), suppurative periostitis alone, and combined with ostitis superfi- cialis, or caries. But osteoplastic periostitis may combine with caries, and this combination is even frequent, i. e., osteophytes form round a carious point in the bone. If you examine a series of preparations of carious joints, you find the osteophytes starting from the surface of the bone, around the destroyed portion ; the periostitis, which at one place induced destruction of the bone, caused formation of new bone in the vicinity. You may very aptly compare this to an ulcer with callous edges — thickening by new formation in the periphery, de- struction in the centre. But we do not have formation of osteophytes at the periphery in atonic forms of caries ; it only occurs in those which, at least for a time, bore a proliferating character ; just as in torpid, scrofulous ulcers you only find thickened edges where the skin had for a long time been thickened by plastic infiltration, so in the bone also we have this combination of proliferation and destruction which we have so often met in the study of inflammation. 458 CHRONIC INFLAMMATION OF THE PERIOSTEUM, BONE, ETC. LECTURE XXXIII. Primary Central, Chronic Ostitis, or Caries. — Symptoms. — Ostitis Interna Osteoplas- tica, Suppurativa, Fungosa. — Abscess of Bone. — Combinations. — Ostitis with Ca- seous Metamorphosis. — Tubercles of Bone. — Diagnosis of Caries. — Dislocation of the Bones after their Partial Destruction. — Congestion Abscesses. — Etiology. Hitherto we have only treated of chronic ostitis in so far as it is dependent on periostitis. This is almost always the case in the hol- low bones, for in them the cortical layer is not much disposed to be- come primarily diseased. The case is different with the spongy bones and bony parts ; in them a chronic inflammation may arise indepen- dently, just as in the medullary cavity of a hollow bone there may oc- cur a circumscribed chronic osteomyelitis, so that the cortical substance may become diseased from within. These cases are designated as ostitis interna or caries centralis. The symptoms of such a chronic inflammation, occurring deep in the bone, are in many cases very un- decided. A dull, moderate pain, and a consequent slight impairment of function, often form the only symptoms. Swelling comes on later, and the disease may exist for months before we can form a certain diagnosis. But when we find severe pain on pressure, and oedema of the skin, and the periosteum participates secondarily in the chronic inflammation, we shall gradually be led to the correct diagnosis, the more readily if the disease be circumscribed, and perforation finally takes place, so that we may pass a probe through the opening deep into the bone, and find exactly what is the state of affairs. In many cases periostitis is for a long time the chief symptom of ostitis ; the former may be so prominent that it appears to be the only disease, till, from the long duration, and from losses of substance from within, or lastly, perhaps, even by detachment of small pieces of bone, attention is called to the fact that the continued suppuration is due to disease deep in the bone. It has already been stated that chronic inflamma- tion in bone first shows itself by the chalky salts becoming soluble. So far we have only studied cases where the disease was circum- scribed and progressed inward from the surface. Now, imagine an ostitis developing in a spongy bone, as one of the tarsal bones, or in the diaphysis of one of the long bones, as in the lower part of the tibia, and the chalky salts disappearing from the bony tissue while the vessels of the medulla increase, and the medulla, infiltrated with wandering cells, gradually takes the place of the disappearing bony tissue. Here we have the picture of a pure ostitis malacissans, an osteomalacia inflammatoria or rarefying ostitis ( Volkmann). In this OSTITIS MALACISSANS. 459 affection the bones become very light, and the cortical substance very thin. Mindfleisch has shown how the atrophy occurs in such cases ; for he discovered that the chalky salts were first dissolved and disap- peared as in lacunar corrosion. But while in the latter case the osseous tissue disappeared with the chalky salts, in the present case the tissue continues to exist for a time ; the cases where every trace Fig. 75 A. Ostitis malacissans : a, vertical section of the calcaneus, diseased anteriorly and posteriorly, normal in the middle ; b, vertical section of the upper end of the tibia, quite porous. of bone inside the periosteum has disappeared in this way, show that the osseous tissue which has lost its salts is finally absorbed itself. But whether this is always the case, or whether it ma}^ again be im- pregnated with chalky salts and again become normal bone, is not known. Whether this variety of atrophy, which may correctly be termed halisteresis ossium (from a/lc, salt, and (jreprjatg, robbing, Kilian), always runs the course shown in Fig. 76, is not fully inves- tigated ; possibly the chalky salts and the tissue might be absorbed at the same time. The fact that there is no sign of proliferation in the bone corpuscles of the tissue deprived of its chalky salts seems to prove that they are not disposed to proliferate. So we have here a form of inflammation of bone in which its atrophy is a particularly prominent feature, and there is a very scanty formation of osteophytes, or this may be altogether absent. In the bone there is no regenerative process ; the medulla, which is 460 CHRONIC INFLAMMATION OF THE PERIOSTEUM, BONE, ETC. reddened from the great vascularity, usually contains fat, but is richer in young cells than the medulla of the bones of adults usually is, and hence more resembles the condition in childhood. The ostitis malacissans may remain in this state ; should it slowly progress, it would lead to complete solution of the bone, till only medulla and periosteum remain, and the bone is so soft as to yield to any trac- Fig. 76. Disappearance of the chalky salts from the peripheral portions of the o&seous framework in ostitis malacissans. Magnified 350. After Rindfleisch. tion or pressure ; but this is rare. According to my experience, it is just as rare for the medulla in these bones to suppurate or become caseous without some external cause ; but this is sometimes induced by violent probing, dirty probes, bruising, or operations. Mild cases of this form of ostitis may recover by formation of new bone in the cavities of the old bone ; while severe cases in marasmic patients are incurable and require amputation. Ostitis osteoplastica is just the opposite of the above ; we do not how whether the disturbance of nutrition by which it is started also begins with loss of chalky salts from the bone ; the main effect of the disturbance is abnormal formation of new bone in the medulla and in the Haversian canals. When the disease occurs in the long bones, it generally attacks the whole bone at once, and even affects several bones at the same time. The result of this disease may be the com- plete filling of the medullary cavity, with a tolerably compact bony SCLEROSIS OF BONE. 461 mass, the almost complete filling of the Haversian canals with bony sub- stance, and generally also the for- mation of bone on the surface. Fio.77. Thus the entire bone becomes very heavy and denser than normal. This process is also termed diffuse hypertrophy of the bone, but more frequently sclerosis ossium (con- densing ostitis, H. "Vblkmanri). Besides the hollow bones, other bones of the skeleton are also oc- casionally attacked, e. g., bones of the face and pelvis ; in such cases the bony deposits are spongy, puffed, nodular, so that the bone acquires a resemblance to skin af- fected with elephantiasis ; indeed, the diseases are very analogous (Leontiasis ossium, Virchow), The filling up of the diploe be- tween the outer and inner tables of the cranial bones with bony substance is such a common change with advancing age, that it can hardly be considered as pathological, although it really belongs under this head. The causes of sclerosis of bone as a primary disease are entirely obscure; in some cases syphilis may act as a cause, but the osseous formations occurring in this dis- ease rarely attain such firmness as in sclerosis proper. The mal- ady will rarely be recognized with certainty during life, because to the touch these bones present nothing more than a certain increase of thickness and a slight ine- quality of surface. Ostitis interna suppurativa circumscripta usually begins in a hollow bone as osteomyelitis. The inflammation gradually extends to the inner surface of the cortical substance, which is dissolved, as we have already stated, and finally completely consumed at some Sclerosed tibia and femur; the former after Follin, the latter from a specimen out of the Vienna Pathological Anatomical Collection. 462 CHRONIC INFLAMMATION OF THE PERIOSTEUM, BONE, ETC. point. In such cases pus may form quite early in the centre of the inflammatory new formation, and subsequently be evacuated. It is this disease that is especially termed bone abscess. The periosteum does not remain unaffected ; it is thickened and new bony deposits form in this case also from the surface of the bone, which is not at first perforated but is irritated from within. The hollow bone is thus enlarged externally at the point where the abscess forms in it, and gives the impression of the bone being here pressed apart and in- flated. It is difficult, indeed often impossible, to distinguish such a bone-abscess from a circumscribed osteoplastic periostitis, hence we should not be in too great haste to operate. This central caries may be accompanied by partial necrosis of certain portions of bone on the inner surface of the cortical substance, forming a caries necrotica centralis. Lastly, we have the worst cases, where chronic internal and external caries are accompanied by necrosis and by suppurative or osteoplastic periostitis. All these develop in one and the same hollow bone at the same time ; abscesses appear at different points ; with the probe we sometimes touch rotten bone, sometimes a seques- trum ; in one place we enter the medullary cavity of the bone, in another only the surface appears diseased ; the whole bone is thick- ened, as is the periosteum, and a little thin pus escapes from the fistulous openings. The macerated preparation of such a bone has a peculiar appearance ; the surface is covered with very porous osteo- phytes; between these, here and there, we find necrosed portions which belong to the surface of the bone ; some openings lead into the medullary cavity ; if you saw through these bones longitudinally, you find the medullary cavity also partly filled with porous bony sub- stance ; the cortical layer has lost its even thickness, and it also is porous, so that it is only at some few points that it can be distin- guished from the osteophyte deposits; in the original medullary cavity we find occasional round holes, and in some of these necrosed portions of bone. These bones are in such a state that their recovery cannot usually be expected, and either their extirpation or amputa- tion of the limb is necessary. In the short, spongy bones the case is somewhat different; in them, when there is proliferating, inflammatory neoplasia, solution of the bone with secondary suppuration comes on quite rapidly, although it is not an absolutely necessary result. There are cases of ostitis of the short spongy bones of the wrist and ankle, and especially in the epiphyses of the hollow bones, where, without any decided swelling (which is usually caused by the resulting periostitis), the bone is en- tirely dissolved by interstitial granulations growing all through it, without any necessary accompaniment of the slightest trace of sup* DISLOCATION OF BONES AFTER PARTIAL DESTRUCTION. 463 puration {ostitis interna fungosa). The result of such a solution of bone in these, or in other joints, is that by muscular traction the bones are displaced in the direction where the destruction is most advanced. And from this deformity we may judge approximately of the extent of the destruction. A short time since, I amputated a foot which was so distorted by such a destruction of bone, without any suppuration, on the inner side of the talus and calcaneus, that the inner border of the foot was greatly drawn up, just as in well-marked congenital club- foot, and the patient walked very insecurely on the outer border of the foot. A good-sized ulcer had also formed on the outer edge, which had latterly entirely prevented walking. I saw a similar case in the wrist-joint : A girl twenty years old had suffered for a long time from pain in the left wrist, without swelling of the soft parts ; pressure on the wrist was very painful; gradually, without any swell- ing or suppuration, the hand became very much abducted ; if the pa- tient were anaesthetized, the hand could be returned to its normal position, and then it was found that part of the wrist had entirely dis- appeared. In the larger spongy bones, as the calcaneus, and in the epiphyses of the larger hollow bones, a central cavity, or a bone-abscess, may form, and this may be accompanied by a necrosis centralis. In the great majority of cases, however, the ostitis is accompanied by a purulent periostitis ; this is particularly the case in the small bones of the wrist and ankle ; these are so small that, when the periosteum be- comes diseased, the disease readily extends to the entire bone and its articular surfaces, and that conversely primary disease of the bone quickly shows its effect on the periosteum and articular surfaces. In these cases also there is implication of the sheaths of the tendons and of the skin, which is perforated at various places by ulceration from within outward. In the hand the radius and ulna as well as the articular ends of the metacarpal bones may also be implicated, and in the foot the lower ends of the tibia and fibula, as well as the posterior ends of the metatarsal bones. The wrist and ankle joints are thus swollen out of shape ; in many places thin pus escapes from the fistulous openings, and the bones of these joints are partly dissolved and partly replaced by spongy granulations, or else are entirely or partly necrosed. It is hardly necessary to tell you that the course of this form of primary suppurative ostitis also, in regard to vital re- lations, is just as variable as that of chronic periostitis, and that here also you see cases of a typical atonic, and others of a fungous variety, while there are a variety of cases between these extremes. I must particularly mention one other form of chronic ostitis, viz., ostitis with caseous degeneration of the inflammatory neoplasia. You are already acquainted with this variety of chronic inflammation ; it 464 CHRONIC INFLAMMATION OF THE PERIOSTEUM, BONE, ETC. belongs generally to the atonic forms, with slight vascularization. It occurs chiefly in the spongy bones, and readily combines with partial necrosis ; in the cheesy pulp which fills the cavity in the bone there are almost always portions of dead bone that have not been dissolved. The vertebras, the epiphyses of the larger hollow bones, and the cal- caneus, are the most frequent seat of this ostitis interna caseosa. This form is only recognizable in a few cases during life; we grad- ually arrive at the diagnosis of os- titis interna, but can only deter- mine its special form in cases where the half-fluid caseous pulp is evacuated through an external opening. Lastly, we must not omit to mention that in rare cases, usually in the vicinity of caseous deposits, true miliary tubercles, small, at first gray, later cheesy nodules, come in the spongy sub- stance of the epiphyses in the an- kle-bones and vertebras and induce solution of the bone and partial necrosis. A diagnosis of this true bone tuberculosis cannot be cer- tainly made during life, we may onty consider it as probable where there is marked tuberculosis of the lungs or larynx. For all forms of ostitis, which induce softening of the bone-sub- stance, JR. VolJcmann employs the designation rarefying ostitis*. Foint of caseous degeneration in the spinal column of a man. From the occasional remarks that I have made concerning the diagnosis of chronic periostitis and ostitis, you will have already seen that, after they have lasted a certain time, their recognition is not generally difficult, but that it is not always possible to state the variety and extent of any given case. There are two very important factors for the diagnosis in those cases that cannot be examined di- rectly by the sound, viz., the displacement of the bones, which must result, in many parts of the body at least, from their partial solution, and formation of abscesses, which often accompanies it. DISLOCATION OF BONES AFTER PARTIAL DESTRUCTION. 465 Carious destruction of the larger hollow bones rarely goes so deep as to cause a solution of continuity ; where this might otherwise oc- cur, it is often prevented by osteophytes growing on the outside while the destruction goes on within, so that the bone grows thicker at the point of disease. I have only seen one case where, from a perfectly atonic caries of the tibia of an old, decrepit person, the bone was at one point so far consumed that there were entire loss of continuity and spontaneous fracture; post-mortem examination showed that there was not a trace of osteophytes. The bone in Fig. 66 is also nearly eaten through. Complete destruction of the substance of the small hollow bones of the phalanges and metacarpi is not so rare ; the scrofulous caries of these bones has from time immemorial been called JPcedarthrocace, or spina ventosa, old names that only mean caries in the fingers or toes, with spindle-shaped enlargements. Should the bones be entirely destroyed by the fungous proliferation and partial necrosis of the small diaphyses, the fingers atrophy and are drawn back by the tendons so strongly that they represent misshaped rudi- ments of fingers. Displacement of the spongy bones is far more frequent when they are destroyed. I have already spoken of this as occurring in the wrist and ankle bones, still, it occurs far more extensively in other bones ; for instance, if the head of the femur and upper margin of the acetabulum are destroyed, the -femur is gradually drawn up in pro- portion to the amount of destruction, and assumes the position that it has in upward dislocation of the hip. Similar dislocations occur in the shoulder, elbow, and knee, though there they are less remarkable. About the most noticeable are the dislocations in the spinal column after carious destruction of the vertebrae ; if one or more vertebrae be destroyed by ostitis, the part of the spinal column lying above this point has no firm support, and must sink ; but, since the arches of the vertebrae and spinous processes are rarely diseased at the same time, only the anterior part of the spinal column sinks in, and an anterior curvature results, and a consequent posterior projection, a so-called Pottfs boss, thus named after the English surgeon, Percival Pott, who first accurately described this disease. In every anatomical collection you find preparations of this, unfortunately, rather common disease. The occurrence of such a boss is occasionally the sole, but tolerably certain, sign of caries of the vertebrae. A second important symptom of destruction of bone, or caries, is the suppuration which accompanies many or most cases. The pus collects around the diseased bone ; a cold abscess forms ; the pus does not always remain at the point where it forms, but sometimes sinks deeper, particularly when it has displaced the parts from within out- 30 466 CHRONIC INFLAMMATION OF THE PERIOSTEUM, BONE, ETC. ward, so that it reaches the loose connective tissue. The most fre- quent source of such sinking or congestion abscesses is the above disease of the vertebrae; as this most generally begins as chronic periostitis on the anterior side of the vertebrae, so this is the most Fig. 79. Destruction of the vertebral column by multiple periostitis and ostitis anterior. Preparation from the pathological anatomical collection at Basel. common seat of the suppuration ; the pus sinks behind the peritonaeum, along the psoas muscle, and usually makes its appearance below Poupart's ligament, and to the inner side ; it may possibly, but more rarely, take a different course, as backward. These congestion ab- scesses are of great diagnostic and of still greater prognostic value ; CHRONIC OSTITIS. 467 as a rule, they are bad signs ; their treatment, of which hereafter, is one of the most difficult points in surgical therapeutics. In speaking of the sinking of pus, it is meant that, following the laws of gravity, the pus sinks mechanically; it will do so most readily where there is simply loose connective tissue present, and no opposition from fascia, muscles, or bone. But I must call your attention to the fact that this purely mechanical picture is only partly correct; for it is partly an ulcerative suppuration that progresses in a certain di- rection, which is only slightly influenced by the pressure of the pus ; the abscess enlarges as it does in other cases ; if the pus reaches a point under the skin of the thigh, perforation usually results, not from the mechanical pressure of the pus, but from ulceration from within outward, as in the opening of other abscesses; such a congestion ab- scess may last one and a half to two years before opening spontane- ously. We come now to the etiology of ostitis and caries interna, which we may treat very briefly, as the chief factors act here as in chronic periostitis, or in chronic inflammations generally. It is, on the whole, rare for injury to induce ostitis chronica ; but this may develop in the form of an osteomyelitis in one of the larger hollow bones, from severe concussion and bruising, with extravasation of blood in the medullary cavity ; the same thing may occur from contusions of the bones of the wrist or ankle. But it is more com- mon for such causes to induce acute disease, such as acute periostitis. If suppuration take place after contusion of the wrist or ankle, if the cartilage be destroyed and the suppuration extend to the bone, we may have fungous ostitis of the small spongy bones, and their complete destruction. Even healthy, strong persons may, from protracted traumatic inflammation of the joint, become so ansemic and cachectic that the disease will not go on to its normal termination, but becomes chronic. Most frequently scrofula and syphilis are the causes of chronic in- flammation of the bones ; in scrofula, while the children are fat and well-nourished, the fungous forms predominate. In thin, badly-nour- ished, scrofulous children, on the contrary, ostitis with caseous degen- eration and other atonic forms not unfrequently develop ; both of the latter lead to partial necrosis. The most frequent seats of scrofulous ostitis and periostitis are the vertebras, articular epiphyses, phalanges, and metacarpal bones ; the jaw-bones and large hollow bones are rarely affected. In syphilis, ostitis and periostitis osteoplastica are most frequent in the tibia and cranium ; caries sicca fungosa also occurs, some- times primarily in the diploe of the skull, sometimes after periostitis ; 468 CHRONIC INFLAMMATION OF THE PERIOSTEUM, BONE, ETC. the sternum, palatine process, and nasal bones, are often affected ; ne- crosis often follows syphilitic caries. Some recent authors, such as JR. Vblkmann, represent syphilis of the bone as something peculiar, under the name of ostitis gummosa / I acknowledge that certain com- binations are particularly frequent, giving rise to typical pictures of the disease ; but, anatomically, syphilis in the bone is nothing more than ostitis and periostitis. In many cases, even on most careful ex- amination, we are unable to find any local or general cause for the existing caries, and I consider it better to admit this than to try with all our might to discover some dyscrasia. LECTURE XXXIV. Process of Cure in Caries and Congestion Abscesses. — Prognosis. — General Healtn in Chronic Inflammations of the Bone. — Secondary Lymphatic Enlargements. — Treatment of Caries and Congestion Abscesses. — Resections in the Continuity. Before passing to the treatment of chronic periostitis and ostitis, we must add a few remarks about the process of cure in caries, and about the prognosis. The first will vary somewhat with the activity of the process, as it does in ulcers of the skin. Supposing the pro- cess of proliferation in the new formation to cease, the interstitial granulation-tissue will gradually shrink together, and be transformed into cicatricial tissue. Considered histologically, this process consists of the retrogression of the gelatinous intercellular substance into firm, filamentary connective tissue, while the richly-developed capillary vessels are mostly obliterated, and the cells acquire the character of connective-tissue cells. If the caries was accompanied by suppura- tion, the latter gradually ceases, and the fistulae close. If part of the bone had already been destroyed by the ostitis, and there was dis- placement a it does not disappear, but the loss of bone is supplied by a retracted connective-tissue cicatrix, and the dislocated bones are united in their false position by such a cicatrix ; this connective tissue gener- ally ossifies subsequently. The cicatricial union of two dislocated bones, as of two vertebras, which have come into contact by the destruction of a vertebra previously lying between them, also ossifies, and thus unites the vertebras firmly ; the actual substitution of bone for any neoplasia to such an extent as to straighten the spine again, or en- tirely or partly to replace any other bone, never occurs in caries. Should an atonic ulcer of the bone heal, it may do so in one of two ways : either any portion of bone that has become necrosed must PROCESS OF CURE IN CARIES. 469 be detached and thrown off, then by a rich development of vessels, a vigorous new formation must form from the walls of the defect, and when there has been a large excavation or abscess in the bone the entire cavity must be filled with granulations before recovery is pos- sible—for a perfect cure these granulations must cicatrize and ossify, and to a certain extent the torpid ulcer in the bone must become pro- liferating — or else granulations arising from the healthy bone behind the diseased, necrosed portion dissolve the latter ; at the same time the torpid process becomes proliferating, and thus leads to cicatriza- tion. The defects in bones, for example, in the centre of a hollow bone, cannot decrease by contraction, which so much curtails healing in the soft parts, but must be entirely filled up by new tissue. This is the point that so often prevents recovery in caries, for the constitutional conditions at the root of the torpid form of caries are often so serious that it is not only difficult to arrest the advance of the ulceration, but is just as difficult to induce active new formation in the seat of disease. If we actually succeed in arresting the process of ulceration, fistulae not unfrequently remain and continue for years, or never heal. Never- theless, when the disease remains stationary, the fistulae in the bone rarely do much harm. If you have a chance to examine such fistulae anatomically in macerated bones, you will find that the holes leading into the bone are lined by an unusually thick, sclerosed layer of bone, just like old fistulas of the soft parts, whose walls consist of a hard cicatricial substance. We have still to speak of the process of cure of chronic cold abscesses in certain diseases; usually, if not opened, these do not heal till the bone-disease is on the way to recovery. Then, if the cavity of the abscess be lined with vigorous granulations, as is rarely the case, the walls may unite immediately ; but more fre- quently, when such an abscess ceases to increase, it is first contracted by shrinkage of its inner walls, and is thus gradually closed. For this to occur it is requisite that the process of destruction should have ceased on the inner wall, and that the tissue should be suf- ficiently vascular. If a cold abscess do not open, but remain subcu- taneous, while the bone-disease recovers, most frequently a large part of the pus, whose cells disintegrate into fine molecules, is absorbed, while the inner walls of the abscess change to a cicatricial tissue, which, in the shape of a fibrous sac, contains the puriform fluids. Such pus-sacs often remain in this stage for years ; unfortunately, complete reabsorption, or absorption to such an extent as to leave only a cheesy pulp, is much rarer than might be desired, and than is usually sup- posed. In the prognosis of a case of caries, we have first to consider sepa- rately the fate awaitir g the diseased bone, and the state of the gen- 470 CHRONIC INFLAMMATION OF THE PERIOSTEUM, BONE, ETC. eral health induced by long suppuration of the bone and soft parts. Regarding the fate of the part diseased we have already said enough, having on the one hand described the process of destruction and its results on the parts around, and on the other the mode of the possible cure. Here I shall only add the remark that, in caries of the vertebras, as we may readily see, the spinal medulla may be endangered, by participation in the suppuration, or by being so bent, by the inclina- tion of the vertebrae, that its function is destroyed ; thus we may have paralysis of the lower extremities, of the bladder, or of the rectum, from caries of the spine. Practically, this is rarer than might have been expected a priori^ because the spinal medulla is considerably protected by the hard dura mater, and bears quite an amount of grad- ual curvature without impairment of its function. The state of the general health, the grade and variety of the febrile reaction, are of general prognostic significance. Chronic diseases of the bone rarely begin with fever; indeed, in many cases, especially when there is no local treatment, and the consecutive abscess is allowed to open spontaneously, the patient escapes fever altogether. But this per- fectly afebrile course does not continue ; if the patient has remained free from fever previous to the opening of the abscess, after this there is usually hectic fever, which is generally a remittent fever with steep curves, i. e., low morning and high evening temperature. The earlier large cold abscesses are opened the sooner the afebrile passes into a febrile state, and not unfrequently there is an intense, exhausting, continued remittent fever; the chronic ulceration then often becomes an acute inflammation, with great tendency to disin- tegration of the diseased tissue ; after the thin, flocculent, but not badly-smelling' pus is evacuated, there is occasionally sanious sup- puration, which may be only temporary. In such cases pyaemia may be the winding-up of the whole disease. It is difficult to state the cause of this change of course after open- ing of a cold abscess, why the chronic inflammation should so quickly change to an acute form. The common supposition is, that the entrance of air excites severe inflammation in the walls of the large abscess cavity, which were already disposed to disintegrate, and that the oxygen of the air is the especial cause of the decomposition. This view may be correct in many cases, but it is not the air itself or the oxygen that is injurious, nor is it always the organic germs contained in the entering air. But it is certain that sometimes puncture or any method of opening gives enough irritation to excite an acute, spreading inflammation of the badly-organized walls of the abscess. In many cases also infectious matters may be inoculated by the in- struments or dressings. [In the Medical News and Library ', July, PROGNOSIS OF CARIES. 471 1878, Dr. S. W. Gross expresses his belief that the circulation and nutrition of the walls are disturbed by the withdrawal of the con- tents ; more blood is sent to the sac, its surface becomes studded with granulations from dilated capillaries, and pyogenesis is in- creased. After evacuation he recommends compression by adhesive plaster and bandages, and keeping the parts at rest.] The possi- bility of the chronic process becoming acute in this way justifies the prognosis that opening of the abscess increases the danger. We may here add that the general health is first decidedly affected by the suppuration ; caries fungosa, whether running its course without suppuration or with only a slight amount, is consequently less dangerous to life than caries atonica, with great tendency to suppuration and decomposition. This prognostic point is also based on good grounds, for, as we have previously stated, proliferating inflammatory new formations more frequently occur under compara- tively favorable constitutional conditions. If the fungous prolifera- tions break down quickly, if the suppuration becomes more profuse and thinner, it is a bad sign, a sign that the general health has also become impaired. The strength is used up partly by the production of pus, partly by the fever, and is only partly replaced because reabsorption does not go on properly from the stomach, digestion is not good ; this reacts again on the local disease, and thus the general and iocal state are most intimately connected. The smaller the carious spot, the less dangerous it is for the general health ; still there are certain localities where it is more dangerous than elsewhere ; thus suppuration of the vertebrae, with large congestion abscesses, is very dangerous, while caries of the phalanges, even if several be attacked, has little effect on the general health ; there is great difference in the danger to life according to the joint and diaphyses attacked ; caries of the hip, knee, or ankle, is far more dangerous than in the shoulder, elbow, or wrist. Of this we shall speak more particularly when treating of diseases of the joints. The age is also of great prognostic importance in caries — the younger the patient the better hope of recovery ; the older he is, the less hope : in caries coming after the fiftieth year, whether a sequent of periostitis or primarily as ostitis, the prognosis as to recovery is very doubtful, insignificant as the local disease may be at first ; I do not remember ever to have seen caries in old persons so frequently as at Zurich. Lastly, the prognosis depends greatly on the constitutional disease to which the caries is due. Relatively, syphilitic caries is the most favorable, "because we can treat syphilis the most successfully. In well-nourished children scrofulous caries also is rarely dangerous to 472 CHRONIC INFLAMMATION OF THE PERIOSTEUM, BONE, ETC. life, as the scrofula disappears spontaneously, or after the use of proper remedies. But caries in atrophic scrofulous children is dangerous, be- cause such children easily die of exhaustion. The prognosis in caries is most unfavorable where there is already pronounced tuberculosis ; it very rarely recovers ; the pulmonary disease generally advances rapidly and acute miliary tuberculosis develops in the serous membranes, and sooner or later terminates life. The patient, dying slowly from chronic suppuration, gradually grows more and more emaciated, pale, and very anaemic, at last oedema of the lower extremities comes on ; he eats less, and finally, after years of suffering, he dies of marasmus, often very slowly ; some- times he sinks to rest quietly ; sometimes struggles for days with death. Formerly it was generally supposed that death in these cases was solely due to gradual exhaustion ; but more careful examinations have shown that the exhaustion and impoverishment of the* blood often have very palpable causes. For in these cases we often find the liver, spleen, and kidneys, in a state of fatty or amyloid degeneration (Hyalinose, 0. Weber), a variety of degeneration which consists in the deposit in the substance of the organ, from the smaller arteries, of a peculiar material characterized by its lardaceous consistence, and by its reaction ; on addition of iodine and sulphuric acid, it colors partly deep-reddish brown, partly dirty-brown violet, with a play of colors into green and pale red. Concerning the nature of this material there are various views, which you will find more detailed in the patho- logical anatomies. I shall only tell you here that the above reaction with iodine and sulphuric acid is similar to that of cholesterine, and that consequently Heinrich Meckel von Hemsbach believed that the fatty substance owed its reaction to the large amount of choles- terine it contained. Others thought that this material was allied to amylum, and hence Virchow, who held this view, called it amyloid. Kuhne subsequently showed that both of these views were untenable. The so-called amyloid is a peculiar substance, closely allied to albu- men ; it differs from albumen particularly by its insolubility in acids containing pepsin. From the mode of its occurrence this material is very interesting and noteworthy ; it and fibrine are the only organic bodies we know that pass in fluid form through the vessels, and out- side of these coagulate firmly in the living body, without the vital power of cells appearing necessary. The saturation of the liver, spleen, and kidneys, as well as of the walls of the intestinal arteries and of the lymphatic glands, with fat, must naturally have great influence on the formation of the blood, and finally prevent it entirely ; thus, in most of these cases death is caused by disorganization of the blood. Extensive chronic suppurations TREATMENT OF CHRONIC PERIOSTITIS. 473 greatly predispose to fatty degenerations; hence, in patients with extensive caries we should carefully attend to this point, though fre- quently we cannot avert it. Besides tuberculosis and amyloid degen- eration, which unfortunately not unfrequently combine, these poor patients are occasionally also endangered by the common forms of acute and chronic diffuse nephritis, or morbus Brightii. I will also mention that, in chronic inflammation of the periosteum and bone, the proximal lymphatic glands often participate in the dis- ease. As in acute inflammations the lymphatic glands are often infiltrated and excited to acute inflammation by material coming to them from the point of disease, so in chronic inflammations the same thing occurs and from the same cause. The lymphatic glands swell slowly, painlessly, but often enormously in the course of months and years ; the tissue of their frame-work thickens, some lymphatic ves- sels are obliterated, while others increase in size ; rarely it goes be- yond this hyperplastic swelling ; occasionally there are small abscesses and points of caseous degeneration. Now, after having examined chronic periostitis and ostitis from all sides, it is time to think of the treatment. In so doing, after having spoken of these diseases in their most varied extent and combination, we must again begin with simple chronic periostitis. The treatment should be at once general and local ; in all cases where dyscrasial causes are evident, they should be chiefly treated, and on this point I refer you to what was said in the general consideration of these dys- crasice in the chapter on chronic inflammation. Therefore in this place we shall chiefly consider local remedies. Rest of the diseased part is the first and most general rule in the treatment of chronic inflamma- tion of the bone; for movement, accidental blows, falls, etc., may change what would have been a mild, not injurious course, to an acute and dangerous one ; hence, in most cases of disease of the bones of the lower extremities lying quiet is of the first necessity, in the upper extremities carrying the arm in a sling. This rest is particularly im- portant in diseases of the bone near the joints ; under such circum- stances rest is often spontaneously resorted to because motion is pain- ful. Some forms of fistulous caries become so quiet and painless, when suppuration externally begins, that motion has no effect on the diseased bone, and in such cases moderate motion may be allowed. Elevation of the diseased part is a good adjuvant to the treatment, for it avoids venous congestion. This mechanical aid to the escape of the blood must not be undervalued. 34 When the first symptoms of chronic periostitis and ostitis begin, 474 CHRONIC INFLAMMATION OF THE PERIOSTEUM, BONE, ETC. treatment should aim at inducing resolution. For this purpose, power- ful antiphlogistic remedies are of little use. The application of leeches or cups, the internal administration of purgatives, the appli- cation of bladders of ice, seem to me only beneficial in acute exacer- bations of chronic inflammation ; their action is always very tempo- rary, and the employment of local bloodletting and purgatives may even prove injurious if often repeated. The repeated application of leeches and cups proves locally irritant, and may finally make the pa- tient anaemic, and a continuance of laxatives exhausts his strength ; hence we should employ these remedies sparingly, reserving them for the acute exacerbations. Recently Esmarch has very urgently recom- mended the continued application of bladders of ice in chronic in- flammation. In cases accompanied by great pain, I have seen very good effect from this treatment ; in other cases I see no true indica- tion for their use. Most frequently, at the very commencement of chronic inflamma- tion of the bone, the resorbent and milder derivative remedies are proper : officinal tincture of iodine, ointment of iodide of potash, mercurial ointment weakened by the addition of lard, mercurial plas- ter, ointments made with concentrated solution of nitrate of silver, hydropathic dressings and mild compression-bandages. With these remedies, and proper constitutional treatment, we make our first at- tack on the diseases in question, if they are just commencing, and occasionally we succeed in arresting them at an early stage. In the early stages of serous and moderately-plastic infiltration and slight vascular ectasia, the retrogressive changes either occur without leav- ing a trace of morbid change, or perhaps leave a moderate formation of osteophytes. In this stage, the treatment of syphilitic diseases of the bone by active antisyphilitic remedies is the most successful. If the process progresses, and the caries runs its course without suppuration, we may continue with the above remedies, and in suit- able cases, in otherwise vigorous persons, may combine with the above, derivatives to the skin, such as fontanelles, the hot-iron, etc. If the signs of suppuration begin, and abscesses form, you may con- tinue the absorbent remedies for a time, in the hope of even yet in- ducing reabsorption ; it is true, this will not succeed in most cases, but the question will soon arise : Shall we open the abscess, or wait for it to open ? On this point I give you the following general rule : If the abscess comes from a bone on which an operation is impossible or undesirable (as the vertebrae, sacrum, pelvis, ribs, knee-joint, etc.), do not meddle with it, but be thankful for every day that it remains closed, and wait quietly till it opens, for thus there will be relatively the least danger. When I have departed from this principle, I have TREATMENT OF CHRONIC PERIOSTITIS. 475 always regretted it. I saw, with great pleasure, that Piriogoff said almost exactly the same thing. Experience has sufficiently shown that none of our operations, aiming at imitating the slow spontaneous opening of these abscesses, prove as little irritating as the slow per- foration of the skin from within by ulceration. Various methods have been proposed for opening large cold abscesses, corresponding to the theories in regard to them. For a time it was thought that the pus must escape slowly, in order to prevent inflammation of the abscess- walls. To accomplish this, setons were introduced, and the pus allowed to trickle from the points of opening. Then it was claimed that, besides this slow escape of matter, the skin should be perforated slowly. For this purpose, a caustic was applied to the thinnest spot of the abscess, and a slough made, which gradually became detached, whereupon the pus slowly escaped. Subsequently it was supposed that we should carefully avoid the entrance of air, as this was the dangerous point ; so a trocar was introduced, a portion of the pus was evacuated and the opening accurately closed, or the so-called subcu- taneous puncture, according to Abernethy, was made, i. e., the skin over the abscess was lifted up, and a narrow-bladed knife was passed under it into the abscess, a large part of the pus was evacuated ; then the knife was quickly withdrawn, and the skin allowed to go back into its original position, so that the puncture in the skin did not communicate directly with that in the abscess-sac, but the latter was covered by the skin ; the cutaneous opening was carefully closed. Subsequently great importance was attached to placing the walls of the abscess in such a condition that the formation of pus should cease ; it was thought that this could be done by injecting solutions of iodine after the pus was evacuated ; this method was especially popular in France. Recently a French surgeon (Chassaignac) has returned with great enthusiasm to the old setons ; but, instead of these, he chose fine tubes of caoutchouc with perforated walls, so that the escape of the pus was greatly facilitated (Drainage, page 176). Lister, an English surgeon, particularly urges that in opening these abscesses the instruments and dressings should be previously disinfected with carbolic acid, and also that the entrance of air should be carefully avoided ; his proceeding, like all previous ones, has enthusiastic advo- cates. It is not easy to decide on the value of all these methods ; but, when such a number of remedies and methods are recommended, you may almost always decide that the disease in question is very difficult to cure, and that none of the remedies are suited for all cases. Let us briefly criticise the above plans of treatment. A single evacu- ation of the pus, do it as we may (we regard free openings of con- gestive abscesses as universally abandoned), has at first a tolerable 476 CHRONIC INFLAMMATION OF THE PERIOSTEUM, BONE, ETC. result, if done slowly and carefully, whether with the trocar or sub- cutaneously with the knife, with or without Lister's carbolic-acid treatment. If the opening is nicely closed and heals up, there is usu- ally no fever, but the abscess fills again very quickly ; an abscess that probably took ten months to form, may fill again in ten days. This is also punctured ; the opening again closes ; the patient grows fever- ish ; the pus again collects rapidly. A third, and perhaps a fourth or fifth, puncture is made, always in a new spot ; the patient grows more feverish, the abscess is hotter and more painful ; the patient looks languid and suffering. Now the points of puncture cease to heal, the previous ones open again, there is a continual escape of matter, and occasionally, in spite of all our care, air enters, especially when the walls of the abscess are rigid and do not collapse. Now there is a fistula, the fever is continued, and the subsequent course is most un- favorable, as we described it above. So far as my experience goes, the course is not much changed if the puncture be followed by injec- tion of iodine. There is not much difference if you make the opening with a seton, with drainage-tubes, or by cauterization. I have seen nothing from any of these methods that in the least approximated the claims of their proposers. It is true this unfortunate course may be run if you do nothing to the abscess but leave it to itself and await its opening ; but then all progresses more mildly and slowly, and fever comes on later. Recov- eries take place under all these modes of treatment, but I think there are more recoveries, and certainly fewer deaths from pyaemia, under the expectant treatment. I am satisfied that where recovery has fol- lowed injections of iodine, drainage, etc., it would also have occurred had the course of the disease not been interrupted ; we cannot accept the assertion that a case would have run its course thus and so, if this and that had not been done. Summing up my own experiences, I can assure you that, of very many cases of large congestive abscesses along the spinal column, artificially opened, I know very few that ran a favorable course ; the others were only hastened to their end. Hence I again repeat the previous assertion, that these abscesses, especially congestive abscesses from caries of the vertebrae, are a noli me tangere. In such cases it is indeed frequently very difficult to wait ; in private practice, especially, the patients become impatient ; the surgeon is urged to do something, it is cast up to him that he does not try any thing ; the public firmly believes that, if the pus was only out, recovery must follow. The surgeon also at length becomes weary; it is trying to look on from week to week as the abscess increases; all local and constitutional remedies are exhausted, and finally the surgeon departs from his principles and makes an opening ; at first all goes TREATMENT OF BONE ABSCESSES. 477 well, but this does not continue ; you already know the subsequent course. The case is somewhat different when we have to deal with small abscesses originating in disease of bones of the extremities ; in suppu- rations connected with the larger joints, we also willingly postpone opening ; we shall speak of this hereafter, under diseases of the joints. In cold abscesses from the diaphyses delay is not of much avail ; here I rather consider an early opening as proper, except in syphilitic gummata ; in these cases there may be reabsorption, even after there is evident fluctuation, and in markedly tuberculous or debilitated persons, in them no operative interference is indicated, and opening the abscess would only induce profuse suppuration, without doing any good. In the other cases I am in favor of opening the abscess freely, to obtain a clear view of the variety and extent of the disease ; under these circumstances the reaction is insignificant, frequently there is no fever, often there is moderate fever for a short time. Let us suppose a chronic periostitis with caries superficialis of the diaphysis of a hollow bone ; an abscess has formed and been opened ; the wound is at first dressed with charpie, and we then wait to see what appear- ance the surface of the ulcer will assume. The local treatment should be modified according as the ulcer is proliferating or accompanied by breaking down of tissue, and I should only be repeating, were I to refer again to the proper remedies. The treatment may be aided by local baths, which we may render slightly irritant by the addition of potash or tincture of iodine. Wet compresses, cataplasms, charpie- wads wet with various fluids, serve as dressings. The subsequent course will show more and more to what extent the bone-disease de- pends on the general health. If the patient be a weakly, tuberculous individual, all local remedies are in vain ; if the general health be good, you may even resort to energetic local treatment. If the ulcer does not improve under milder remedies, you may apply the hot iron ; should this be followed by formation of strong, healthy granulations, it is a favorable sign, even if there be necrosis of the carious portion of bone. In other cases we abandon all idea of inducing healing, and cut out the entire affected part. For this purpose there are various forms of cutting forceps and saws ; I prefer detaching the diseased bone with scrapers, gouges, and hammer, to all other methods. If the ulcer of the bone has been cleanly cut out, and the general health be tolerably good, it is to be hoped that the wound of the bone made in the opera- tion will heal normally by healthy granulation and suppuration, as other wounds of bone do. Should the caries affect a small bone, it may be proper simply to extirpate it, to arrest the process at once. If the case be one of ostitis interna, caries centralis of a hollow bone. 478 CHRONIC INFLAMMATION OF THE PERIOSTEUM, BONE, ETC. or of a large, spongy bone, such as the calcaneus ; if severe pain and other previously-mentioned symptoms of bone-abscess gradually ap- pear, it may become proper to chisel out the bone, or open the cavity of the bone and let out the pus ; but I only advise this operation when you are sure of your diagnosis, for it is no slight injury to a patient to have a healthy medullary cavity opened. Yery acute osteomyelitis, with its often dangerous results, may arise from untimely interference, while a similar operation on a diseased bone is not usually very seri- ous. In other cases you will await the spontaneous opening of the abscess through the bone ; then you may use a probe, and judge accu- rately of the state of affairs. The obstacles to the healing of such excavations in the bone have been previously mentioned ; should the process remain stationary for a long time, it may be best to enlarge the opening in the bone, expose the abscess, and remove its walls ; this will be the more necessary if there are any small necrosed por- tions of bone in the abscess-cavity which prevent its healing ; that is, if the case be one of caries necrotica. But all these manipulations are only indicated if the general health be good; if there be ad- vanced tuberculosis or marasmus, and the disease will necessarily prove fatal, no surgeon would wish to do an operation which can only prove successful when the local changes in the new wound of the bone go on normally. These operations, part of which, at least, may be classed among the partial resections in the continuity, have lost their cruel and terrible appearance since the introduction of chloro- form, by whose aid the patients escape feeling the chisel, hammer, and saw. In those cases where the caries is so extensive as to affect the whole thickness of a long bone, we might think of sawing out the en- tire diseased part. This case is very rare, and such operations are of extremely doubtful benefit. We might, it is true, saw out a piece from the middle of the fibula, radius, or ulna, from the metacarpal or meta- tarsal bones, without greatly impairing the function of the extremity ; but, should we do the same for the humerus, femur, or tibia, and re- covery take place, the function of the extremity would, at most, only be partially restored by aid of an apparatus ; in the lower extremity an artificial leg would be of more use than a leg that had lost a con- siderable portion from the continuity of the bone. It has been thought that the periosteum, detached from the bone before it is sawed, and left in the wound, would form new bone ; but after opera- tions for caries this regeneration of bone is very scanty, so that we cannot count much on it. Moreover, caries is the rarest indication for these total resections in the continuity. Lastly, in regard to those cases which are on the whole rare, where TREATMENT OF BONE ABSCESSES. 479 a hollow bone is diseased throughout with periostitis, external and internal caries, partial internal and external necrosis, there can only be a question of extirpation of the entire bone, or amputation of the affected limb, Cases of extirpation of the entire ulna or radius oc- casionally turn out well ; extirpations of the first metacarpal bone are often successful. I also know of a case where the whole humerus was removed, leaving behind the thickened periosteum ; but the pa- tient died a few months after the operation from some internal dis- ease, morbus Brightii, if I mistake not, so that no decision could be made about the usefulness of the extremity ; in spite of the absence of the humerus, the hand might have been of service, which of itself would have been a great gain to the patient. Caries of the short, spongy bones, and of the articular epiphyses, is so intimately con- nected with diseases of the joints that we shall discuss it hereafter. The state of general marasmus that finally occurs from diseases of the bone, with extensive suppuration, is to be treated on general principles. We should try to prevent its occurrence, or at least ward it off to the utmost. It is the physician's duty to preserve life as long as possible. It is also his duty, even in a patient almost cer- tainly dying, to give him every thing that can keep up his strength. Nourishing, tonic, strengthening diet is to be given from the time the first symptoms of emaciation show the failure of nutrition ; later it is of no use. In children and young persons the inexperienced physician may readily be deceived as to the strength, and you will hereafter see that patients in a very bad state, emaciated to a skele- ton, and excessively anaemic, pick up wonderfully and unexpectedly on amputation of the diseased limb, which seemed to be consuming their life ; of course benefit could rarely result from resection under such circumstances. How far it is safe to carry the principle of pre- serving the limb by sawing out the diseased portion of bone can only be judged of in individual cases, and then only approximately. LECTURE XXXV. Necrosis.— Etiology.— Anatomical Conditions in Total and Partial Necrosis. — Symp- toms and Diagnosis. — Treatment. — Sequestrotomy. Gentlemen : We have already frequently spoken of " necrosis," and you know that by this term we mean gangrene of the bone, death of a bone, or part of a bone. I have also told you that the dead portion of bone is called a sequestrum. You also know that necrosis 480 CHRONIC INFLAMMATION OF THE PERIOSTEUM, BONE, ETC. may result either from an acute process, or accompany the process of ulceration as " caries necrotica." As in death of any part, cessation of circulation is also the im- mediate cause of necrosis, while cessation of nervous activity does not induce it, although a disturbance of nutrition, an atrophy of the bone, is occasionally seen in paralyzed parts. Necrosis may be due to various causes ; we shall briefly group them together : 1. Traumatic influences. Among these are severe concussions and injury of the bones, even without external wounds. The course is as follows : As a result of the above injuries there are extravasations in the medulla of the bone, also into the spongy bones, perhaps also in the compact bony substance, and occasionally under the periosteum. If these ruptures of the vessels be so extensive that their results cannot be removed by collateral circulation, which is of difficult es- tablishment in bone, part of the bone will no longer contain any blood ; this will die, and, according to circumstances, we may have central, superficial, or total necrosis (the latter occurs most readily in the small bones). The portion of dead bone remains in the organism as a foreign body, but still continues in continuity with the healthy bone ; the solution of the sequestrum, by liquefaction of the bone- substance in the border of the living tissue, has been already ex- plained (page 220). Another mode of injury is exposure of the sur- face of the bone, or sawing through a bone, by which the sawed sur- face becomes the surface of the bone ; in complicated fractures a piece of bone may be so denuded of soft parts, and thus robbed of its circulation, that it becomes necrosed. We have also explained why the exposed bone or sawed surface does not always become ne- crosed, but that the bone may, like the soft parts, immediately pro- duce granulations. Nevertheless, after the above injuries, superficial or partial necrosis is common enough, either because extensive clots form in the ends of the injured vessels of the bone, or because the vessels are compressed and suppurate on account of the acute suppu- ration in the Haversian canals. 2. Acute periostitis, ostitis, and osteomyelitis, are very frequent causes of occasionally extensive and especially of total necrosis of the hollow bones. In suppuration of the periosteum the supply of blood to the bone, by vessels passing through the periosteum, is cut off, and the suppuration is propagated through the Haversian canals to the medullary cavity ; if the latter also suppurates, necrosis is in- evitable, and will extend as far as the inflammation did. The same results will occur in primary acute ostitis and osteomyelitis with sec- ondary periostitis. 3. Chronic ostitis and periostitis may combine with necrosis, for, ANATOMY OF NECROSIS. 481 just as in the acute processes, suppuration, change of the inflamma- tory new formation to detritus or caseous matter, extends into the bone, and so impairs its circulation that part of the bone is no longer nourished and must necrose ; atonic forms of caries induce necrosis more readily than the fungous forms, as has already been stated. The necrosis that is supposed to occur after thrombosis or embo- lism of the chief trunk of the nutrient artery of a bone appears to be of more theoretical than practical importance. This variety of ne- crosis has hardly been proved by dissections on man ; it is, moreover, very improbable, because the arterial supply, in full-grown bones, comes from so many sources that stopping one of the many afferent branches does not suffice to completely arrest the circulation in any considerable portion of bone. Although the collateral circulation in bone cannot, from mechanical causes, be greatly facilitated by dilata- tion of the vessels, and hence in capillary stasis there is always danger of partial necrosis, as already stated, still the connection, arrange- ment, and regular distribution of the capillaries, even in the firm cor- tical substance, are such that when the afflux is interrupted from one source it may easily come from another. In bone there are no defined capillary net-works and capillary groups as in the skin', but all the cap- illaries are intimately connected in all directions, as in the muscles. The experiment of inserting a peg into the foramen nutritium in the upper part of the tibia of rabbits has been tried, and it has been followed by necrosis around the peg. I have made this experiment and obtained the same result by inserting the peg at any other part of the bone, and hence I believe that this experimentally-induced ne- crosis depends only on the variety of the injury to the bone. It will be proper now to study more accurately the anatomical course of necrosis, especially of that coming after acute periostitis and osteomyelitis. I have already told you, on various occasions, when treating of the healing of fractures and of chronic ostitis and periostitis, that the vicinity of such collections of pus is almost al- ways affected in such a way that osteophytes form on and in the bone ; their development is greatly influenced by the periosteum, and also by the surrounding parts (where they form after fractures). While solid healing is due to this new formation of bone after frac- tures, in chronic ostitis and periostitis it is more an accidental prod- uct of irritation, which subsequently has no further significance. The same thing is true in superficial necrosis. When, from new de- position of osteophytes around the sequestrum, the bone becomes more dense around the point of disease, whether this be exfoliation of one of the cranial bones, or a sequestrum from a sawed surface, it has no further practical importance. It is different in complicated 31 482 CHRONIC INFLAMMATION OF THE PERIOSTEUM, BONE, ETC. fractures : when the broken ends or nearly loose fragments of bone become necrosed, the formation of new bone in the vicinity may not only induce future firmness in the bone, but the sequestrum may be entirely enclosed by the new bone, and it may be necessary to remove it by operation. But this formation of new bone is most important in total necrosis of entire diaphyses; it is intended to replace the bone which dies. This very important process, which is so wonder- fully accomplished by Nature, we must now study more carefully. Let us suppose an acute total periostitis and osteomyelitis with ne- crosis of the diaphysis of the tibia. The entire periosteum and me- dulla have suppurated ; within the bone the pus falls to detritus, or actually putrefies ; the pus from the periosteum has perforated the skin at various points, the circulation in the diaphysis has ceased ; the entire diaphysis is a sequestrum. A longitudinal section gives the following appearance (Fig. 80) : Pig. 80. Diagram of total neerosie of the diaphysis of a hollow hone. a, the sequestered bone ; b b, its upper and lower extremities ; c c, pus surrounding the sequestrum ; d d, where it has perforated exter- nally. The darkest layer, e e, is the wall of a large abscess-cavity, which consists of tissue (connective or tendinous tissue, or even of muscle), infiltrated with plastic matter, and on its inner surface, which lies next the sequestrum, like any abscess-cavity, it has a granulation- layer, which constantly produces new pus. I will mention at once that this view, as in acute periostitis, differs from that of other sur- geons and anatomists, because they suppose the tendinous portion of the periosteum is lifted, like a vesicle, from the bone by the pus ; this is incorrect, because the tendinous portion of the periosteum is not sufficiently elastic to be quickly elevated like an epidermis vesicle, and because this elevation would fail to occur at those points where there is no periosteum, i. e., where tendons are attached to the bone ; but the latter is not the case. The inflammation and suppuration DETACHMENT OF THE SEQUESTRUM. 483 begin partly in the surface of the bone, partly in the softer parts of the periosteum, in its outer layers ; the tendinous portion participates but little ; indeed, it is mostly destroyed. In proof of this I have very decided anatomical evidences. The anatomists and surgeons who believe in the elevation of the periosteum consider the shaded layer, e e, as infiltrated, thickened periosteum ; this is only conditionally true : it may happen that part of the periosteum does not suppurate and enters into the composition of this layer ; however, other adjacent parts may also be so indurated by plastic infiltration as to form a firm abscess membrane, as is often seen in abscesses of the soft parts. Whoever maintains the exclusive power of the periosteum to produce bone will, on theoretical grounds, regard this layer, e e (where bone is subsequently formed), as thickened periosteum. But, in the forma- tion of callus, after fractures, we have already seen that bone in con- siderable quantity may under certain circumstances be produced in other soft parts lying near the bone, and hence we are not obliged to demand periosteum in this thickened layer of the abscess. But we are going on too rapidly. Let us return to our example. The pus-cavity around the sequestrum cannot close till the latter is out of it; but this remains attached at both ends. You already know how the detachment is effected : at b b, in the edges of the living bone, there is an interstitial proliferation of granulations, by which a slight amount of bone is consumed, so that at last the osseous substance is entirely replaced by soft granulations at these ends ; this completes the detachment of the sequestrum (see page 220) ; the granulations form- ing here break down somewhat, soften to pus, and then the seques- trum lies loose in a pus-cavity, which is filled with proliferating granu- lations. In the thick hollow bones this detachment of the sequestrum requires a long time, usually several months, sometimes over a year ; up to this time the pus has escaped from the places where it had per- forated the skin ; if, during this time, you introduce a probe through the openings, you may usually feel the smooth surface of the diaphysis. But, during this process of detachment of the sequestrum, something else is generally going on in the immediate vicinity, to which we shall now turn our attention. In the thickened layer of the pus-cavity, e e, new osseous tissue has formed regularly around the sequestrum longi- tudinally ; this ossification has also continued to the part where the thickened layer again joins the periosteum of the epiphysis and the capsule of the joint, so that the bone-capsule is intimately connected with the epiphysis above and below. The longer the sequestrum remains in the cavity, the more the bony envelope increases in thick- ness ; in time it becomes very thick ; in the course of years, if the sequestrum does not come out, it may be over half an inch thick ; at 484 CHRONIC INFLAMMATION OF THE PERIOSTEUM, BONE, ETC. first, it consists of porous bone, but subsequently is more compact and stronger. A regular cast has been formed around the sequestrum, just like we should make of plaster of Paris if we wish to mould an object ; this cast, however, has several openings, especially where the pus escapes ; their closure is prevented by the constant flow of pus. The above picture (Fig. 80) has now changed to the following (Fig. 81) : Fig. 81. Diagram of total necrosis of the diaphysis of a hollow bone, with a detached sequestrum and new bony receptacle. The sequestrum a is detached and bathed in pus, which is secreted from the granulations above mentioned; d d, the fistulas leading into the pus-cavity (they have received the name cloaca) ; e e is the bony envelope derived from the ossification of the thickened abscess-wall, the so-called bony receptacle. This thickening now progresses regu- larly, if the irritation caused by the sequestrum continues. Let us now suppose that the sequestrum escapes from its case (as happens occasionally — of this later), then, although all the bone of the diaphy- Fia. 82. Fig. 81, after removal of the sequestrum. sis is lost, there is no disturbance of function, for the newly-formed bony envelope supplies the place of the bone that has been lost. Now, what happens ? Will the cavity in which the sequestrum DETACHMENT OF THE SEQUESTRUM. 485 lay continue to suppurate ? No ; if every thing goes on normally, this cavity, like other cavities due to central caries, fills with granula- tions ; these granulations ossify, and the bone is completely restored, at least as regards its form ; observation has not yet determined whether the medullary cavity again forms in such cases as it does after the healing of fractures, but from analogy this is not improbable. After removal of the sequestrum, the healing of these cavities often requires months and years, sometimes it is never complete, especially Fig. S3. Fig. 84. <', total necrosis of the diaphysis of the femur, with extensive bony case replacing the dead portion of bone ; several good-sized openings lead through this bony case to the sequestrum within. &. longitudinal section of the same preparation. a, tibia of a young man after total necrosis of the diaphysis ; about two years previously I had re- moved the sequestrum, b\ the cavity has almost filled with os- teophytes. The patient died from a carbuncle. 486 CHRONIC INFLAMMATION OF THE PERIOSTEUM, BONE, ETC. if the individual affected be constitutionally diseased, or becomes so from the continued suppuration accompanying the process. In these long-continued suppurations from bone, albuminuria not unfrequently develops, although of rather mild form. I do not know whether this may in time spontaneously disappear after the cavity in the bone has healed ; it would be interesting and of prognostic importance to collect observations on this point. After removal of the sequestrum, the thick- ening of the osseous envelope ceases, and the process of ossification establishes itself in the cavity filled with granulations. What I have just demonstrated to you in diagrams, you here see in these beautiful preparations from the anatomical and surgical collection of Zurich. You now know the ordinary normal course of a necrosis. I must next introduce you to some deviations from this normal course. You will remember that, when speaking of acute periostitis, I told you that occasionally the epiphyseal cartilages also ossified (where they still existed, that is, in young persons). When this takes place simulta- neously in the upper and lower ends (a very rare case), of course the sequestrum will be detached, and detached very early, so early that no bone can have yet formed in the pus-cavity, or, if it has, it must still be very weak. If the bone be now extracted, there is nothing yet formed to replace it, nor does any thing form, because the irritation which gives rise to the production of bone is absent, this cause of irri- tation being the sequestrum, as long as it remains as a foreign body in the bone ; hence, under these circumstances, if the sequestrum be extracted early, the extremity becomes boneless and unserviceable. When the epiphysis cartilage suppurates at one end, e. g., the lower end, the sequestrum remains firmly attached above, and the break- ing down of the bone must go on slowly as in other cases ; it may, however, happen, as I saw in one case in the thigh,that the lower end, Fig. Necrosis of the lower half of the diaphysis of the femur, with detachment of the epiphyseal cartilage, and perforation of the skin. DETACHMENT OF THE SEQUESTRUM. 487 loose in the epiphysis cartilage, presses strongly against the skin from within and gradually perforates it, so that it appears externally ; the lower epiphysis of the femur was at the same time drawn up by the muscles, so that the appearance was as follows (see Fig. 85). The sequestrum, subsequently removed, had the following form (Fig. 86) : Flo. 86. The body extracted from Fig. 85. The formation of bone was strong enough to carry the body ; sub- sequently, under chloroform, the knee was straightened, and perfect recovery resulted. I saw a perfectly similar case affecting the lower end of the humerus. In both cases, as is usual in necrosis near the joints, the joint had suffered severely, and became quite stiff. Still, even without early detachment of the sequestrum from softening of the epiphyseal cartilages, under circumstances which we do not accu- rately know, the formation of bone may be very feeble, so that, after the detachment, the new bone is not firm at some point, but is quite flexible, whereby we have a pseudarthrosis of the new bone ; I have seen two cases of this kind : one of these I cured completely by occa- sionally driving ivory plugs into the weak part of the newly-formed bone, thus constantly stimulating the bone to new production ; the object was attained in the course of eight months, and the patient, then twelve years old, now walks like a healthy person. Diagram of partial necrosis of a hollow hone. 488 CHRONIC INFLAMMATION OF THE PERIOSTEUM, BONE, ETC. Partial necrosis of the diaphysis is more frequent than the above complete necrosis ; this may either affect the entire thickness, or only half the circumference, according to the extent of the osteomyelitis and periostitis. You may readily apply what has been said to these par- tial necroses. Here is an example : suppose a periostitis of part of the diaphysis of one femur and subsequent necrosis ; the circumstances may assume the following shape (see Figs. 87 and 88) : a, seques- trum ; b b, its borders ; c c, the pus-cavity ; d, the perforation out- ward ; e e, the thickened ossifying wall of the pus-cavity. A few months later (Fig. 89) ; a, detached sequestrum, which is to Fig. 88. Diagram of Fig. 87 in the later stages, with formation of new bone. be removed ; e e, newly-formed bone-tissue as substitute for the piece of bone that is being lost ; of course, the newly-formed bone covers the sequestrum anteriorly, but, as in Figs. 80, 81, and 82, must be left out to expose to view the sequestrum. Fig. Fig. 88, after removal of the sequestrum. The changes that we have now become acquainted with may also be applied to necrosis in flat and spongy short bones ; but at the same DETACHMENT OF THE SEQUESTRUM. 489 time we must remark that in necrosis of these bones the new forma- tion is much less, often entirely wanting, because the inflammation here is particularly of constitutional origin, and hence occasionally deviates from the normal course ; as a rule, the inflammatory neo- plasia in necrosis of the spongy bones soon assumes the ulcerative character, and then the formation of new bone is but slight ; more- over, acute, non-traumatic periostitis is something very rare in spongy bones. Extensive necrosis may even occur after originally pure ossifying periostitis and ostitis, in case the newly-formed ossific deposit is re- absorbed, suppurates and decomposes at the point of its attachment to the diseased bone ; this gradually affects the nutrition of the bone ; it often continues to live for a long time in the medullary cavity, or rather leads a half existence between living and dying ; this variety of periostitis and necrosis occurs especially in the maxillary bones after chronic poisoning by phosphorous fumes, a disease peculiar to workers in match-factories. I cannot enter more minutely into this phosphorous periostitis and necrosis, which has many noteworthy peculiarities, because it would be necessary to load you with too Fig. SO. 1. Scapula of a young- dog 150 days after the removal of the delineated fragment, which at the time of the resection formed part of the fully-ossified portion of the scapula; the articular surface, edges of the cartilage, and the carefully-detached periosteum, were all preserved. The growth of the bone was unimpeded, and there was almost complete regeneration of the resected portion. 2. Scapula of a young- dog of the same litter, 150 days after an operation performed the same day as the above, and in the same manner, except that the periosteum was removed. The growth was im- paired, and the resected portion was not regenerated. 490 CHRONIC INFLAMMATION OF THE PERIOSTEUM, BONE, ETC. many details, which would now confuse you. If you bear in mind the above-described course of necrosis in the hollow bones, you will have the opportunity of learning in the clinic all the deviations that may occur in any case, from peculiar circumstances, for necrosis is a relatively frequent disease of the bones. I cannot leave the anatomy of necrosis and the regeneration of bone accompanying it, without mentioning an excellent French worker who has spent many years in the study of the osteoplastic power of the periosteum, and has nobly carried forward the previous works of Troja, Flourens, B. Seine, A. Wagner, and others, on this subject : I mean Oilier, who, with untiring zeal, has pursued this study experimentally and clinically, and has closed it up for a long time ; I have repeated part of his experiments, and can only confirm the idea that under certain circumstances, in young animals, preservation of the periosteum decidedly favors the reproduction of bone. In the course of these lectures I have already stated my opinion regarding the osteoplastic power of human periosteum, especially as compared with other soft parts surrounding the bones, and hitherto I have found these views confirmed by every new experience. Quite recently v[ia, 4>vtov, growth, also used by Hippocrates, is now rarely employed. NOMENCLATURE OF TUMORS. GO 3 Celsus occasionally designated tumors in general as " struma," but glandular tumors on the neck were more especially meant. The English term " strumous " what we call " lymphatic, scrofulous." The Germans confine the term " struma " to tumors of the thyroid gland. I have little to say about the external gross appearances of tumors. In most cases the growths are roundish nodules, more or less distin- guishable, by sight and feeling, from the surrounding parts. This is not always accurate, however ; tubercles also, at least in their smallest state, are bounded roundish bodies, which I should no more class among the growths than I should papules and pustules of the skin. In the skin also a distinctly-formed nodule may appear as a growth, just as an abscess may which also at first appears as a nodule. Still, as chronic inflammatory new formations on the surface also frequently appear in the form of papillary proliferations (tufts), a growth forming on the skin or mucous membrane may also assume the papillary form ; even the surface of a tumor, or a newly-formed cavity containing fluid or pulp, may produce papillary proliferations. So you see that growths and inflammatory neoplasia are not accurately distinguishable by their purely external anatomical conditions. There are a number of terms for different }3eculiarities of tumors, which are frequently used even now, although they do not always refer to any essential point. Thus, a tumor situated in a cavity, and attached by a pedicle, is called a polypus / so, we speak of nasal polypi, uterine polypi, etc., but must add the histological peculiarities (as fibrous, myxomatous, etc.). Growths that are ulcerated and pro- ject like a fungus are called spongy ', or fungous. Formerly, if one wished to say that a tumor was very vascular, he used the word " ne- matodes," while to-day it is called " telangiectatic," or " cavernous." If a tumor was very firm or fibrous (not cartilaginous or bony) it was formerly called " scirrhous," which merely means " firm," and was applied- to inflammatory new formations just as to cancer. A tumor was called medullary when it had the color and consistence of the brain, while its structure might be that of sarcoma, carcinoma, or lipoma. As tumors of this appearance are recognized as peculiarly malignant, the terms "medullary sarcoma," "medullary carcinoma," have been applied to malignant tumors in general without regard to their structure. Some growths are colored — brown, yellowish, brownish black, bluish black; this pigmentation may be due to extravasations, or to specific cell-activiy. Melanomata or mela- noses are rare, partly or entirely black or brownish-black tumors, with the structure of sarcoma or carcinoma, and usually of very bad prognosis. Formerly only these and similar terms, and comparisons 604 TUMORS. to this or that tissue, were used ; it is enough for you to know what they mean. We must again return to the term " tumor." Pure anatomy should simply reject this term, for it acknowledges only simple or composite tissue-formations (organized neoplasia of MohitansJcy) ; from a series of observations it can show how these structures develop, and what becomes of them ; we shall not thus arrive at the term " tumor " in the sense in which we use it in pathology. Tumor, or growth, in the pathology of to-day, has a decidedly etiological and prognostic signi- fication ; as stated at the opening of this section, it is a neoplasm that has not started from the same causes as excite inflammation, but from others that are unknown or but vaguely suspected ; the process in the organism (local or general) that produces tumors is generally con- sidered different from inflammation ; some regard the two processes. as antagonistic to a certain extent (we shall not here discuss the correct- ness of this view). If in any given case we have to admit that fac- tors which generally cause inflammation (traumatic, thermic, chemical irritation, etc.) have not caused the development of the tumor, the case seems so unusual that we are disposed to regard the growth as an unusual organism. This pathologic or physiological view, as I might term it, was not formerly maintained, but I do not think I err in stat- ing that, consciously or unconsciously, it is held by most pathologists. All writers on tumors, as much as possible, avoid speaking on this point, as there is nothing more to say on it ; for we do not know how or where we shall draw the dividing line between chronic inflamma- tion and development of tumors. So it is not possible to have a purely anatomical idea of " tumors," any more than it is of the term " typhus ; " to understand them we must make a compromise between etiology and pathological anatomy. The etiological expression, " the process by which tumors are developed," implies that the fate of the product or tumor will probably differ from that of the " inflammatory neoplasia ; " hence we might say of tumors that they do not bear in themselves the conditions for a typical termination, as do the inflam- matory neoplasiae. I would not assert the inflammatory process is at all the opposite of that by which tumors are developed ; on the con- trary, I believe that observation teaches that, in some cases, the two processes correspond, especially in some forms of chronic inflammation and sarcoma, while, on the other hand, acute metritis and fibroid of the uterus are far enough apart, etiologically and anatomically. The idea that the development of tumors has certain specific causes, both in or external to the organism, is little disputed ; and, when it is, it is hardly in earnest. Virchow asserts that the development of tumors may start from an increase of the inflammatory diathesis ; thus, polypi ETIOLOGY OF TUMORS. 605 of the mucous membranes result from long-continued catarrh ; syphilis induces, first, inflammations ; then, tumors. I would incidentally re- mark that I do not consider any product of syphilis a tumor; a gummy nodule or a caseous nodule, caused by syphilis, either heals by reab- sorption, or, after being slit up, by suppurating and cicatrizing, while in an incised tumor this is exceedingly rare. H. Jleekle von Hems- bach advanced the opposite idea, e. g., he says enchondroma of the finger is the mildest expression of a scrofulous diathesis. If we com- pare the products of inflammation with the histologically more devel- oped tumors, it must be acknowledged that, as being the more slowly developed neoplasias, tumors are probably due to a feebler local irri- tation, more allied to normal growth. All these considerations apply only to true growths. In what follows we shall treat of these alone. When Virchow classes encapsulated extravasations of blood and dropsies of serous sacs among the tumors, he goes beyond our pres- ent views. LECTURE XLV. Etiology of Tumors ; Miasmatic Influence.— Specific Infection. — Specific Eeaction of the Irritated Tissues ; its Cause is always constitutional. — Internal Irritations ; Hypotheses as to the Character and Mode of the Irritant Action. — Course and Prognosis : Solitary, Multiple, Infectious Tumors. — Dyscrasia. — Treatment. — Prin- ciples of the Classification of Tumors. Let us now go more minutely into the etiology of tumors. Here we should propose to find the differences and points of resemblance between the processes causing inflammatory neoplasias and tumors. Let us start with the causes of inflammation, and compare them with those of tumors. Many acute inflammatory processes (exanthemata, typhus, etc.), and some chronic ones (intermittents, scorbutus, etc.), are due to miasmata and contagions, which enter the body from with- out. I do not know any acute miasmatic tumors ; but goitre must be considered as a chronic endemic-miasmatic tumor ; goitre cannot be regarded as a product of inflammation, as it never spontaneously ret- rogrades, suppurates, or shrinks up into a cicatrix ; the cause is a spe- cific external one, to which every one, especially the young, is occa- sionally exposed, who comes into a country where goitre is endemic ; all are not equally disposed to it, there may be an hereditary tendency ; infection probably occurs through the blood ; at least, we cannot well imagine how the thyroid gland should be infected by local infection. Hence goitre is probably the local expression of a general infection, which occasionally evinces itself in the whole nutritive state, espe- 606 TUMORS. cially in anomalous development of the skeleton and its results (cre- tinism). We may also consider leontiasis and Oriental elephantiasis as chronic miasmatic infections, in which large masses of nodular fibrous tumors form in the skin on different parts of the body ; still, I acknowledge that this is disputed territory, and that reasons may be advanced for classing these among the chronic inflammatory diseases, instead of among tumors. As regards local infection, or the transfer of fixed contagions from without, we know that inflammations of va- rious kinds may be thus induced. By putrid substances only inflam- mations are induced ; here I class, also, the so-called " dissecting tubercle," which I cannot consider as a tumor, because it disappears spontaneously, as soon as new infection ceases to occur. Inflamma- tion is excited by inoculation with pus; the character of the pus determines the specific nature of the inflammation ; pus may also ex- cite a constitutional disease, which again may evince itself by multiple localized processes, as in syphilis. Can tumors be induced by inocu- lation with the juices of tumors, or with small portions of them? This is a disputed point ; I consider it possible, but not proved ; the difficulty of coming to a decision lies in the fact that it is not allowable to make such experiments on men. When such experiments often fail on the lower animals, it only shows that tumors from man are not transferable to them ; tumors from beasts must be inoculated on beasts of like species ; a few such experiments have been made by Doutrele- po?it, in which the inoculations of carcinoma from dogs on dogs had no effect. At all events, we cannot induce a tumor by inoculating with pus, which again seems to show the specific difference of the products. Perhaps some pathologists may here answer that " molus- cum contagiosum " is an example of tumor-juice or constituents of tumors being inoculable on other persons. This fact, which has been proved by Ebert and Virchow, is very interesting ; still, the right of moluscum contagiosum, a cystoid secretion-hyperplasia of the sebaceous glands, a sort of large comedones, as well as that of re- tention-cysts generally, to a position among tumors is disputed ; and, moreover, the contagiousness of this neoplasia is still too isolated for us to draw any valuable conclusions from it. The most striking proof of the distinctness of inflammatory products and tumors is offered by observation pf the local and general infection, which we have innumerable opportunities of making. We have previously said a good deal about progressive and secondary inflammation of acute lymphangitis, which is always secondary (deuteropathic, ~Vir- chow), of the secondary acute and chronic swellings of the lym- phatic glands in acute and chronic inflammations, especially of the extremities ; I then told you that I considered it more prob- ETIOLOGY OF TUMORS. G07 able that cellular elements from the focus of inflammation passed into the lymphatic glands, and, by their specific phlogogenous action, in- duced inflammation in the glands, which were analogous to the primary peripheral inflammations ; tumors never develop through such local infections from inflammatory foci ; if the primary inflammatory focus be removed, the swellings of the lymphatic glands also disappear. Similar infectious peculiarities also occur in many tumors, especially those which, like the inflammatory neoplasia, are very rich in cells; not only may the immediate vicinity be infected, and numerous new foci be formed immediately around the first nodule, but very often the lymphatic glands are also affected, and secondary tumors form in them, which have the same peculiarities as the primary ; nor are they any more apt to disappear spontaneously than the primary, even when the latter is removed ; on the contrary, similar tumors then frequently appear in other quite remote parts of the body — metastatic tumors. Here you again have the analogy with the course of infection in in- flammation, as well as the specific distinction, for metastatic growths never result from phlogistic infection, any more than metastatic ab- scesses in internal organs do from infection by a tumor. Infection is not common to all tumors, although, unfortunately, the majority are infectious ; these are called malignant, in contradistinction to the benign, or non-infectious. It is difficult to say on what this difference is based ; it is probably partly due to the nature and specific charac- ter of the element, in their easy mobility, and in the fact that, like the seed of some of the lower plants, they find almost everywhere soil suited for their development, and can grow in most tissues of the body ; probably it is also partly due to the fact that the conditions are more or less favorable to the entrance of the elements of the tumor into the lymph or blood-vessels ; for instance, it is remarkable that frequently very soft tumors (medullary sarcoma) consisting almost entirely of cells, when surrounded by a firm connective-tissue capsule, cause no infection of the lymphatic glands ; we notice the same thing in some large encapsulated abscesses. In regard to metastatic ab- scesses, I have already told you that, according to my view, they are due to embolism ; we should have to seek another explanation of diffuse metastatic inflammations. Diffuse metastatic tumors are very rare ; I should apply this term only to a few forms of pleural and peritoneal carcinoma or sarcoma. As regards the mode of origin of metastatic tumors, the actual course of the infection, from analogy, it seems very probable that they, like the secondary tumors of the lym- phatic glands, are induced by seed from the primary tumors, or from the tumors in the lymphatic glands. I acknowledge I am much in- clined to this supposition. Although I could not formerly believe that 608 TUMORS. the cells from a focus of inflammation or from a tumor could be as in- dependent as thistle-down, still, I think that, with our present knowl- edge about the independent life of pathologically-neoplastic cells, there can be no doubt of the possibility of such a process. Quite re- cently an observation has been published which is a new proof of the great independence of the cells of the rete Malpighii ; I mean the epi- dermis transplantation of Heverdin, which has been so often men- tioned. This renders it even more probable than formerly that detached cellular elements of a neoplasm, carried to some other part of the body by the blood or other fluids, may there continue its growth. Although, on the first development of a tumor, as on the occurrence of an in- flammatory new formation, the lymphatic vessels are partly closed, and may be filled with cells, still, subsequently, from compression, lymphatic and vascular thrombi may form, into which specific tumor- elements enter, and small particles of thrombi, which might form during the softening of the tumor, may enter the circulation, become attached at different places, and form new tumors. In veins, the for- mation of such thrombi filled with specific tumor-elements has actually been observed, and, at the same time, analogous tumors have been found in the branches of the. pulmonary artery. It is important to remember that metastatic tumors, like metastatic abscesses, are chiefly found in the lungs and liver, except in cases where direct metastasis is very easy, as in pleural tumors, which develop as a result of primary mammary tumors, as in hepatic tumors found with those of the intes- tines or stomach ; in these cases a direct wandering of tissue-elements through the lymphatic vessels is very possible. On this point there is still much room for investigation, which, I think, will meet great results. As we have already seen, the products of acute inflamma- tion mostly have a pyrogenous action ; those of chronic inflammation lack this peculiarity almost as much as do those of tumors ; fever only occurs in the latter when there is disintegration of the neoplasia, and the products of the disintegration enter the circulation; more frequently, infection with such excreted matters shows itself in chronic inflammation in tumors by a general cachectic state, especially by dis- turbance of the general nutrition. If we consider what has been said about the contagiousness of tumors, we see that there is some probability of their transfer from one person to another, though it is not proved ; but there can be no doubt that the lymphatic glands and other organs may be gradually infected by various kinds of tumors. As regards the effect of taking cold locally and generally as a cause of inflammation, there are no observations which would justify us in referring tumors to a similar cause. I do not know that any one has ever asserted and proved that tumors result from catching cold. ETIOLOGY OF TUMORS. 609 Views vary greatly about mechanical and chemical influences as causes of tumors. Various as the irritations may be, and much as they have been experimented with, in no single case has a tumor been caused intentionally by mechanical or chemical irritation ; inflamma- tory new formations thus developed do not long outlast the external irritation. Wherever and however we apply such mechanical and chemical irritants, we only induce inflammations ; if there be any spe- cific mechanical and chemical irritation (I mean one acting on the or- ganism from without, not starting from the tumor), i. e., one from whose action a tumor must develop, it is at present unknown. Then the question arises whether there are any reasons which render it absolutely necessary to assume such mechanical and chemical irrita- tion outside of the organism. I cannot agree to this. It is true there are many cases where a tumor forms after a blow, kick, or injury, but the number of such cases is very small in proportion to those where, after similar causes, there is acute traumatic inflammation, with a typi- cal course, or, if the irritation be continued, chronic inflammation also with typical course. We must regard this also as a rule : if a porter gets a thickening of the skin, with new mucous bursa under it, on the spinous process, or if he gets an ulcer at the same point, it is to some extent a normal result, they are products of a chronic inflammatory irritation, and disappear as soon as the irritation ceases ; but if from the same causes a person gets a fatty tumor, which does not disap- pear, but even continues to grow when the irritation ceases, we can- not here regard the irritation as specific, but must seek the peculiarity in the affected part. Previously in general and local infections we recognized the specific effects of irritation, now we must also acknowl- edge that there is a specific, qualitative, abnormal reaction of the tis- sue. Virchow and 0. Weber especially have maintained that exter- nal irritation always plays an important role in the development of tumors ; this follows undoubtedly from the fact that primary tumors are most frequent at points most subject to external irritation. Sta- tistics show that the most frequent seat of tumors is the stomach, then the portio vaginalis uteri, then face and lips, then the mammary glands, rectum, etc. But the reason for the development of tumors, and not of chronic inflammation in such cases, must be a specific dis- position of these parts in certain persons. Individuals who drink much spirits usually have gastric catarrh ; if, among one thousand topers, one or even ten, instead of catarrh, had cancer of the stomach, he should be considered as an abnormal subject, when compared with the mass who do not have it. Up to this point I agree entirely with Vtrchoio, who speaks as follows : " Although I cannot tell in what particular way an irritation must occur, to induce a tumor in some 39 610 TUMORS. given case, while in another case, perhaps under apparently similar circumstances, it merely excites simple inflammation, still I have com- municated a series of facts which teach that, in the anatomical compo- sition of different parts, certain continuous disturbances may exist which interfere with the occurrence of regulating processes, and which, from an irritation that at another spot would have induced a simple inflammation, excite an irritation from which the specific tumor is developed." Among facts " which teach that, in the anatomical com- position of different parts, certain continuous disturbances may exist " which dispose to development of tumors, Virchow mentions advanced age. It is perfectly true that certain forms of tumors are very fre- quently found on particular parts of the body in old persons, e. g., can- cer of the lip. Thiersch calls attention to the fact that in the lips of old men the connective tissue is often so much atrophied that the epi- thelial tissues (sebaceous, sweat, and mucous glands, hair-follicles, etc.) become very prominent, and, as it were, receive the preponderance of nutrition ; that hence irritation shows itself chiefly in the proliferation of these epithelial formations, and that this explains the frequent oc- currence of epithelial cancer in the lips of old men. I fully recognize the shrewd combination of these observations, but I must add that advanced age is just as much a general as a local peculiarity of the body, It is also stated by Virchow that places which have been the seat of an inflammatory disease, which has left the part weakened, also cicatrices, furnish foci for the development of tumors. This is undoubtedly true ; but if we compare the innumerable cases where simple chronic inflammation occurs in parts that have been acutely diseased, and where simple ulceration occurs in cicatrices, the cases in which tumors occur at such points appear very small, and it must be acknowledged that in these few cases we may assume a specific pre- disposition which leads to formation of tumors. The same holds good for the fact that tumors are particularly apt to form in organs which complete their formation and development late in life ; here Virchow classes the articular ends of the bone (which, however, are the seat of tumors much more rarely than of chronic inflammations), the mammary glands, the uterus, ovaries, testicles, etc. While fully recognizing the exercise of observation and brilliant ideas by which it is attempted to prove the purely local disposition to development of tumors, I cannot consider the proof as at all convincing, but re- main of the opinion that there is just as much a specific predisposition to the development of tumors as there is to chronic inflammations, with proliferation of the inflammatory new formation, with suppura- tion, with caseous degeneration, etc. To what has just been said we must add that we cannot always ETIOLOGY OF TUMORS. 611 detect a local external irritation when a tumor is developed any more than we can always do so in local disease in a scrofulous patient. While referring you to what has been said on the etiology of chronic inflammations, I would remark that in regard to primary tumors we may assume in many cases that there are also specific, so-called inter- nal irritations developing in the body itself. Most pathologists agree to this, but they consider the mode of origin and development of such irritations as being different. Virchow teaches that the local disease must have a local cause, and assumes that at the point of dis- ease there are certain local conditions of debility. If this were so, we should have to assume a specific local debility for the most different disturbances of nutrition and for formation of tumors. Hindfleisch speaks very decidedly of internal irritation as follows : " By the change of substance in the tissues, certain excretive substances are constantly being formed, which must gradually be passed off from the tissues and organs in which they form, as well as from the fluids of the body at large, in order that the life of the individual may be un- disturbed. These bodies have their chemical position between the organopoietic bodies on the one hand and the excreted matter of the kidneys, skin, and lungs, on the other ; thus they fall into the great gap that exists in organic chemistry at this point ; they are different for the different tissues, and on this difference depends the variety of pathological new formations. If they are transformed and excreted normally they collect first at the point of their origin, then in the fluids of the body, and this collection is the immediate cause for the excitement of that progressive process which begins with multiplica- tion of cells in the connective tissue, and ends with the development of tubercles, cancer, cancroid, fibroids, lipomata, etc." I can entirely agree with this hypothesis, but must add that it seems an error to suppose that we here speak chiefly of local processes. The produc- tion of bile and urine is also a local process ; for them to be produced in such quantities and of such a quality as they are depends not only on the glandular organs, but on the entire organism to such an ex- tent that we must seek the original causes of the secretion of urine and bile not only in the blood, but even more remotely, even in pe- culiarities of origin, as far back as Adam, if you please. In the same way, I think that the original causes for the local requirements for the development of tumors must be sought in specific peculiarities of the individual organism ; in the same way we speak of a scrofulous or tu- berculous person, meaning the pathological race, as it were, to which the individual belongs. I must lastly add that the supposition that the cause of disease, the irritation inducing the tumor, develops local y, where the tumor 612 TUMORS. afterward forms, is as purely hypothetical as any that has yet been advanced. Let us take arthritis as an analogy : Zaleski induced the most typical arthritis in a goose by ligating the ureters ; an articular disease resulting from disturbance of the function of the kidneys . Possibly tumors might just as well develop in any tissue from dis- turbance of the hepatic function ! Very many things are possible. We know nothing certain on this point, and move entirely in hypoth- eses. For my part, I find it just as allowable to assume a diathesis here, as in scrofula, arthritis, etc. ; that, partly from unknown, partly from known causes of general nutrition and ordinary conditions of life, abnormal matters proceed, which have a specific irritant action on this or that part of the body, analogous to that of certain drugs. Lastly, if to this we add that the diathesis for production of tumor is hereditary, although not to such an extent as the chronic inflammatory diathesis, the doctrine of weakness localized in certain systems of tis- sue, or certain parts of the body, seems entirely untenable. There is certainly a local cause for the members of one family having large noses ; in proportion to the face, they have grown larger than in other men, still the large nose of the father cannot descend directly to the son, it can only be inherited from the father through the spermatozoa, and there the original cause is to be sought ; all peculiarities that de- scend by inheritance are unquestionably to be termed constitutional. I have now occupied you some time with reflections which some of you may consider very tedious ; they will ask me, Of what use are these things in practice ? Then, unfortunately, I must acknowl- edge that practice pays little attention to them, because they are so hypothetical. Those of you to whom such ideas as we have just spoken of do not occur, I advise to pay no further attention to them ; not to be obliged to speculate as to the final causes of things is, in a certain sense, an enviable quality. For convenience, let us comprise, in a few short propositions, what we have said regarding the etiology. Tumors, like inflammatory neoplasia, result from irritation of the tissue ; the difference in the causes lies : 1. In the specific quality of the irritation. Infection of healthy tissue about a tumor, neighboring lymphatic glands, etc., is considered sufficient proof of this. It is supposed that, under some unknown circumstances, this specific irri- tan; may be formed locally (Rindfleiscli). I think that, partly as a resi lit of hereditary predisposition, partly from a developed tendency, thaain, but be- cause they impair the function ; this takes place very slowly and gradually, hence the tumors will have attained a considerable size. So long as the patients can use their nodulated swollen fingers, they neither urge the operation, nor can we urgently advise them to sub- mit to it. As regards the mode of operation, in many cases where the tumor, even if firmly adherent to the bone, is seated laterally, it would be natural to try dividing the skin, and pushing it and the tendons to one side, then removing the tumor with the knife or saw. But this is rarely practicable, if we would remove the entire tumor, which is imperatively necessary ; for often the cartilaginous mass en- tirely pervades the medullary cavity of the bone. Moreover, after such an operation, there may be severe inflammation of the sheath of the tendon, as a result of w*hich the finger may remain stiff. There have not been enough careful observations to verify DieffenbacNs assertion, that any remnants of the chondroma that may be left ossify and become stable; hence the removal of chondroma from bone should be limited to few cases, and to those where the tumor is still small. If the tumors have attained a considerable size, we postpone exarticulation of the fingers to a time when the tumors shall have rendered the hand entirely useless. 4. OSTEOMATA— EXOSTOSES. By this term we designate abnormally-formed masses of bone, which are circumscribed, and have an independent growth, not de- pending on a chronic inflammation. Formation of bone also occurs occasionally in other tumors, especially in those forming in bone, as C32 TUMORS. we have already remarked when speaking of chondroma. But the name osteoma is usually limited to- tumors consisting entirely of bone. I may mention here that not only new formations of entire teeth Fig. 122. Odontoma of a back tooth, natural size. Section of an odontoma. Magnified 100 diameters. (very irregularly shaped) occur in ovarian cysts and in the antrum Highmori, but that on the teeth themselves outgrowths of true ivory matter, ivory exostoses (odontoma of Virchow) have been observed ; but these are very rare, and may be regarded merely as curiosities. Exostoses consist partly of spongy bone-substance, like that in the medullary cavity of bones, partly of ivory-like substance, like that in the regular lamellae of the cortical substance of the hollow bones ; hence we shall distinguish spongy exostoses and ivory exostoses. A third form of osteomata is formed by the ossification of tendons, fas- cia3, and muscles, whose right to be classed among tumors is, how- ever, doubtful. (a.) Spongy exostoses, with cartilaginous covering, (exostosis car- tilagina?). These tumors occur almost exclusively on the epiphyses of the long bones ; they are outgrowths from the epiphyseal cartilages, whence Virchow very properly calls them " Ecchondrosis ossificans" OSTEOMATA. 633 (Fig. 124). On their roundish, nodular surface, there is a layer of beautifully-developed hyaline cartilage, about a line or a line and a half thick, which evidently grows partly in itself, partly peripherally from the periosteum or perichondrium, then rapidly ossifies toward the centre. The newly-formed bony mass itself is, from its start, most Fig. 124. lH !i Pedunculated spongy exostosis from the lower end of the femur, after Pean. intimately connected with the spongy substance of the epiphyses, so that the hard tumor is immovably seated on the bone. From the na- ture of these exostoses they can only occur in young persons. Ac- cording to my observation, tibia, fibula, and humerus, are their most frequent seat. {p.) Ivory exostoses. These consist of compact bony substance, with Haversian canals and lamellar systems; they develop on the bones of the face and skull (Figs. 125 and 126), on the pelvis, scapula, grer-t toe, etc., and form roundish, nodulated, or smooth tumors. 634 TUMOES. A third variety of tumor-like formation of bone is the abnormal ossification of tendons, fasciae, and muscle, which usually occurs on a Fig. 125. Ivory exostosis of the skull. series of tendons and fasciae after they have previously ossified a great deal, so that the skeleton of such patients, who are generally young, Fig. 126. / ^ s^ Section from an ivory osteoma of the skull. OSTEOMATA. 635 Fig. 127. are covered with twenty to fifty long, sharp, bony processes, where the tendons are attached to the bone (Fig. 127) ; as in one case observed in Zurich, the ossification occasionally occurs in the fascia of the muscle. Cases have been ob- served where this ossification was so exten- sive that all the muscles of the shoulder and arm were ossified, and the upper ex- tremity could not be moved. These bony neoplasias, as well as the so-called exercise- bones, must doubtless be regarded as the product of chronic inflammation, just like the true bony formations that are abnor- mally developed in the membranes of the brain and spinal medulla. By exercise- bones we mean the development of bone in the deltoid muscle, particularly at those points where the musket strikes when drill- ing. But these bones form in few sol- diers, and their development presupposes a tendency to the formation of bone. Os- sification of the tendons, especially of their points of attachment to the bone, which occasionally occurs from some unknown cause, is also very remarkable, and reminds us of a similar process in birds, which in them is perfectly normal. The predisposition to formation of os- teomata is allied to that for development of chondromata ; it also occurs more frequent- ly in the young, and in men than in women, while children almost escape it. As regards epiphyseal osteomata, which might be termed ossifying chondromata, they of course cannot occur later than the twenty- fourth year. But other exostoses also occur generally before the thir- tieth year ; observations on this point are not very numerous, as the disease is rare. This experience about the occurrence of osteomata in the young is the more remarkable, as it stands in a certain contrast to the general rule of ossification being especially apt to occur in old persons. The cartilages of the ribs and larynx and the spinal liga- ments often ossify in advanced age ; the chalky deposits in the ar- teries of the aged also form part of the almost natural senile maras- mus ; development of osteomata, however, rarely occurs in old persons, Osteoma of the muscular attach- ments, after 0. Weber. 636 TUMORS. but when such tumors are found in them they have usually developed in youth. Osteomata are just as often multiple as solitary; their growth is generally very slow, and is usually arrested with advancing age. The growth of epiphyseal exostoses ceases after the skeleton has completed its growth, and its spongy substance becomes more compact. Ossification of the tendons and muscles rarely goes so far as to entirely prevent motion. In some cases development of bone has been observed in the lung. The inconveniences caused by osteo- mata are not usually great ; their development is not accompanied by pain, nor are they sensitive to the touch ; but osteomata in the vicin- ity of joints often impair their function. When these tumors occur on the bones of the face, they cause unpleasant deformities ; exostoses on the big-toe prevent wearing the shoe ; ossification of the tendons and muscles impairs or entirely prevents motion ; but unfortunately, from their size and number, operative surgery can do little for the lat- ter, and the less so, as the tendency to morbid development of bone still continues. The operation for exostosis consists in sawing or chiselling the tumor from the bone affected. But, as the latter is occasionally in the vicinity of a joint, the articulation might thus be opened ; it is neither advisable nor necessary to undertake such opera- tions unless the impairment of function be so great as to balance an operation dangerous to the joint and to life. We should be the less inclined to undertake such operations without some special indication, as in the course of time these tumors cease to grow. On epiphyseal exostoses we occasionally find mucous bursas containing adherent, or loose ossifying chondromata ; these mucous bursas usually communi- cate with the joint in whose vicinity the exostosis is situated. Ac- cording to the investigations of Mindfleisch, the mucous bursas are always abnormal elongations of the pockets of the articular synovial membrane. I once allowed myself to be induced, by the entreaties of a patient, to remove such an exostosis on the lower end of the femur with a large mucous bursa; the patient died of septicaemia. In another case the mucous bursa over an exostosis on the lower end of the humerus opened spontaneously after moderate inflammation j there was suppuration of the elbow-joint, with anchylosis; the patient would not permit resection of the joint. MYOMATA, NEUROMATA. 637 LECTURE XLVII. 5. Myoma. — 6. Neuroma. — 7- Angioma: a, Plexiform ; 5, Cavernous.— Operations. 5. MYOMATA. At present it remains undecided whether there are pure myomata y i. e., tumors consisting entirely of transversely-striated muscle-fila- ments or their cells ; I do not know that any such have been observed. The occurrence of newly-formed transversely-striated muscle-fila- ments has been very rarely observed in tumors. No tumor was ever entirely composed of them ; they were usual]y an accidental occur- rence in sarcoma or carcinoma (of the testicle, ovary, or mamma), or in tumors of very complicated formation. I have examined tumors in which there were distinct stages of development of muscular fila- ments, but the right of classing such tumors as myomata has been disputed. I can say little against this, as we cannot call tumors, con- sisting of grades of development of connective tissue, fibromata, and as I formerly objected (page 619) to terming uterus fibroma, composed of spindle-cells, myomata, as we are not quite sure of the relation of spindle-cells to muscle-cells. In old men, extensive newly-formed smooth muscles occur in the prostate, partly as independent nodules, partly as diffuse enlargements of the organ. There is certainly no objection to terming these so-called prostatic hypertrophies (there is usually some coincident glandular) myoma ; similar myoma-nodules, are met in the muscular coat of the oesophagus and stomach. Clinically, nothing certain can be said of myomata in these conditions ; the tu- mors which I considered as young myomata in the muscles had, on section, a medullary fascicular appearance an insuperable tendency to local recurrence, and thus caused death. 6. NEUEOMATA. It has already been mentioned (page 622) that the name " neuro- ma " is often applied to tumors occurring on the nerves ; this is, if you please, a practical misuse, which, however, it is difficult to root out. By " true neuroma " we mean a tumor composed entirely of nerve- filaments, especially of those with double contours ; they appear to come only on nerves, and are very rare. Neuromata in amputation- stumps have already been mentioned (page 117) ; many doubt whethei there are any other true neuromata. True neuromata are always very painful. Many of the fibromata on and in nerves contain very peculiar bundle-like fine filaments richly supplied with nuclei, which may very 638 TUMORS. well be taken for gray filaments containing no medulla, as Virchow considers them ; this would make true neuromata a large class, and di- vide them into myaline and amyaline forms. I do not always trust myself to distinguish an amyline neuroma from a fibroma in a nerve, and hence should not require it of others. Tumors composed of spin- dle-cells arranged in bundles are probably far oftener young myomata and neuromata than young fibromata, but it would be difficult to prove to which class they belong. Multiplicity and tendency to regional recurrence are peculiar to neuromata, hence the prognosis should always be guarded. It is rarely possible to dissect a neuroma from the nerve ; part of the latter must generally be removed with it. 7. ANGIOMATA— VASCULAE TUMOES. By this term we mean tumors composed almost exclusively of ves- sels held together by a slight amount of connective tissue ; they have also been called [nasvi, mother's-marks] " erectile tumors," being firm- er or softer, larger or smaller, according to the fulness of the vessels. The ordinary forms of varicose dilatations of the veins and the aneu- risms of different arteries are excluded by this definition. But circoid aneurism and some forms of aneurismal varix might be classed here ; yet, as this is not customary, we treated of these diseases earlier. Here we have to consider two different varieties of vascular tumors : (a.) The plexiform angioma or telangiectasis (from reXog, ayyeiov, Enraotg), This is the most frequent form ; this neoplasia is composed entirely of dilated and tortuous capillaries, and anastomosing vessels, and, according as the proliferation of the vessels or the pure ectasia predominates, it appears more as a tumor or as a red spot on the skin. Plexiform angiomata, of the variety we are about to describe, occur almost exclusively in the cutis. They have sometimes a dark- cherry, at others a steel-blue color ; are sometimes as large as a pin- head, again as large as a hemp-seed ; some are moderately thick, others scarcely rise above the level of the skin. There are very rare forms w T here there is not a red spot or a tumor, but a diffuse redness over a large surface ; in such cases, even with the naked eye, we usu- ally see the distended and looped fine vessels on the surface of the cutis, showing through the epidermis. Anatomical examination of large extirpated angiomata of this variety shows that they are com- posed of small lobuli as large as a hemp-seed or a pea ; and, if, after artificial injection or other mode of preparation, we examine them microscopically, we shall find that these lobuli are formed by the ves- sels of the sweat-glands, hair-follicles, fat-glands, and fat-lobuli, being independently diseased, and that the different small proliferating, vas- cular systems form the above-mentioned lobuli, which are visible to AXGIOMATA. 039 the naked eye. The reason for the color of these tumors being some- times blood-red, sometimes pale bluish, is that, in the former case, the capillaries of the most superficial layer of cutis, in the second, the deeper vessels, are diseased. As a rule, this proliferation of vessels does not go beyond the subcutaneous cellular tissue ; rarely it affects the deeper tissues, such as the muscles ; whence it appears that these neoplasias not only grow centrally, but especially peripherally, and destroy the part affected. Most of these tumors may be slowly emp- Fig. 128. Con florae ration of vessels from a plexiform angioma. Magnified 60 diameters, a, proliferating vascular net-work around a sweat-gland ("which is not shown, to prevent complicating the drawing) ; 6, proliferating vascular net-work in the papillae of the oral mucous membrane. tied by pressure, and again fill as soon as the pressure ceases. But there are also moderate-sized telangiectases, in which, besides the proliferation of vessels, there is also a new formation of connective tissue and fat, so that they cannot be entirely removed by pressure. When these new formations were superficial in the cutis, and the blood has been emptied from them after extirpation, with the naked eye we can hardly see any thing abnormal in the morbid piece of skin that has been removed ; a moderate neoplasia of this variety appears on the cut surface as a pale-reddish, soft, lobulated substance, in which we can see no vessels with the naked eye, because the whole disease is usually limited to the capillaries and minute vessels, and to a few small arteries. 640 TUMORS. (b.) Cavernous angiomata, or cavernous venous tumors. We wih first determine their anatomy, so that you may at once correctly note their difference from plexiform angiomata. Extirpated cavernous angiomata may at once be recognized, on section, by having almost exactly the formation of the corpus cavernosum penis. You see a white, firm, tough net-work, which appears empty, or at least con- tains only in spots red or discolored coagula, or possibly is filled with small, round, chalky concrements, so-called vein-stones ; but we must imagine the mesh-work as distended with blood previous to its extir- pation. The boundary of this cavernous tissue, which may form in all the tissues of the body, is sometimes evidently a sort of capsule ; but in other cases this cavernous degeneration is very indistinctly bounded, and at different spots, in a rather indifferent manner, it enters the tissue. Microscopic examination of this mesh-work, which is formed sometimes of thin threads, sometimes of membrane-like capsules, shows that the branches are formed of remains of the tissue in which Fio. 129. Mesh-work from a cavernous angioma of tne lip (the blood is to be imagined in the large meshes between the net-work). Magnified 350 diameters. the cavernous ectasia occurs. The inner wall of the space filled with blood is, in most cases, coated with spindle-shaped cells (venous endo- thelium), so that even these anatomical conditioDS go to prove that we have to deal chiefly with distended veins. The mode of development of this peculiar tissue has received different explanations. If we had any accurate investigations about the development of ANGIOMATA. 641 the corpus cavernosum penis, we might draw some definite conclusions from them, on account of the great analogy of the two tissues. The three chief hypotheses about the development of cavernous tumors are as follows : 1. It is asserted that the cavernous spaces first develop from the connective-tissue, and secondarily become connected with the vessels ; and it has even been suggested that blood might be de- veloped outside of the circulation, from the derivatives of the connec- tive-tissue cells ; the striae of the mesh-work would increase by inde- pendent growth, by sprouting, and club-shaped growth of the connec- tive tissue (Roltitansky). This hypothesis, especially the formation of blood outside of the circulation, has some objections. 2. It is asserted that circumscribed dilatations of small veins occur close to- gether, and that at the points where they come in contact the walls are gradually thinned or entirely disappear. This view is supported by the fact that these gradual distentions of the veins may occasion- ally be distinctly followed out both in the cutis and bones when these tumors are developing. 3. JRmdfleisch claims that vascular ectasia, especially in the cavernous tumors which form in the orbital fat, is always preceded by infiltration of the tissues with small cells, which is followed by a sort of cicatricial shrinking of the tissue, and conse- quent tearing apart of the vessels, whose calibre must constantly be increased by continued atrophy of the intermediate tissue. For some reasons I have long supposed that both in plexiform and cavernous angiomata there was some process similar to inflammation, but neither the latter (scarcely applicable to the cavernous tumors in bones) nor the former two hypotheses appear to fully explain the causes and peculiar differences in the distention of the vessels. We have still to mention one difference between cavernous tumors : they are either connected with the large venous trunks, as sacs to the sub- cutaneous veins, or numerous small arteries and veins sink into the capsule of the cavernous tissue. Lastly we must mention that these cavernous venous ectasias may occur accidentally in other tumors as in fibroma and lipoma, as has already been mentioned. A few years since I extirpated a lobular lipoma, which had formed below the scapula of a vigorous young man, all of the lobes of which had centrally degenerated to cavernous tissue. Cavernous angiomata de- velop with especial frequency in the subcutaneous cellular tissue, more rarely in the cutis and muscles, very rarely in bones, but quite often in the liver, particularly on its surface, occasionally also in the spleen and kidneys. They are sometimes quite painful, other cases are not at all so. The diagnosis of cavernous angiomata is not always easy ; when they occur in the cutis, they may be mistaken for more deeply-seated 41 642 TUMORS. telangiectases, although the blood may be pressed out of the cavernous venous tumors more readily than from telangiectases. Deeply-seated tumors of this sort are always difficult to recognize with certainty ; the}' usually show decided fluctuation, are somewhat compressible, swell on forced expiration ; but the last two symptoms are not always distinct, hence they may readily be mistaken for lipomata, cysts, and other soft tumors ; sometimes, indeed, this mistake cannot be avoided. Probably half the angiomata are congenital, or at least developed soon after birth. If they develop during life, it is usually in childhood or youth ; it is rare for vascular tumors to occur during manhood or old age, which is very remarkable, as the disposition to vascular dis- eases, especially to ectasia of the vessels, greatly increases with ad- vanced age. Not only the larger arteries and veins dilate at this time, but also the small anastomosing vessels and capillaries, at certain localities, show visible dilatations through the skin. On the face of a ruddy, healthy old man we see red cheeks as we do in the young; it is not, however, the regular rosy bloom of a maiden's cheek, but a more bluish red, and, if you look more closely, you find numerous tortuous vessels, visible to the naked eye ; in some, this redness occurs in spots. These small vascular ectasias do not occur in all old persons, so that we must suppose them due to a peculiar predisposition. Hence, as we said, in spite of the fact that advanced age is more disposed to disease of the vessels than any other time of life, true vascular tumors develop almost exclusively in youth. There is no doubt that the te- langiectasias, which popularly are often called " mother's-marks," are often inherited. This appears to be proved by a number of stories about children, that have been lost, being subsequently recognized by marks inherited from the father or mother. We should undoubtedly learn far more of the hereditary transmission of vascular tumors if we would attend more to that of diseases of the vessels generally. Even if plexiform and cavernous angiomata are to be regarded as anatomi- cally distinct from each other, and from the different varieties of va- rices and aneurisms, it is still clear that a predisposition to dilatation of the vessels is at the root of all of them ; this is undoubtedly to a great extent inherited, and the above diseases can only be regarded as different modes of appearance of this predisposition at different ages. Hitherto attention has been so exclusively paid to the ana- tomical conditions of the tumors that the classes of diseases accom- panying them have been too little noted. As regards the further fate of angioma, telangiectasia?, which are almost always congenital, may be either solitary or multiple. Their growth is alwaj^s slow, painless, and is sometimes chiefly superficial again in the depth, and usually at the expense of the diseased tissue. AXGIOHATA. 643 There is no doubt that occasionally in the course of years these tumors cease to grow, but remain unchanged. But in other cases the growth continues so that the tumors, as I once saw on the neck of a boy five years old, may grow almost as large as a man's fist. Frequently two or three telangiectases occur congenitally, or occur in quick succes- sion, especially on the scalp, more rarely there are six or eight, I have seen two cases of flat congenital plexiform angiomata of the left side of the face, which healed at some points, partly from ulceration, partly from unknown causes; i. e.. cicatricial white spots occurred here and there, where the vessels were obliterated, while in the periphery the proliferation progressed. Cavernous angiomata are rarely congenital, but generally occur in childhood or youth, more rarely later in life. As already remarked, their seat is chiefly in the subcutaneous cellular tissue, more frequent- ly in the face, more rarely on the trunk and extremities. They often occur in large numbers, but in such a way that a certain vas- cular district is to be regarded as the seat of disease, as an arm, a foot, leg, or face, etc. Besides the disfigurement, the symptoms in- duced are a certain weakness of the muscles, and occasionally pain in the part affected. The tumors may attain considerable size, and thus especially on the head prove dangerous, the more so, as by further progress they enter and destroy the bone. Some observations that I know of show that in these tumors, as a result of thrombosis of the cavernous spaces, there may be atrophy and retrogression (especially in the cavernous tumors of the liver) ; but complete disappearance of the angioma by spontaneous obliteration has not been observed. — Treatment for vascular tumors is very varied. The operations have two different objects : 1. Methods aiming at coagulation of the blood, with consequent obliteration and atrophy of the tumor. Among these are injecting the tumor with liquor ferri sesquichlorati ; also transfixing them with hot needles, or the galvano-cautery, and drawing a platinum wire through, and subsequently heating it with the galvano-caustic appa- ratus (galvano-caustic setaceum). We must also mention continued compression of the tumor and ligation of the afferent artery. Both of the latter have gone out of use, as they have proved entirely worthless. 2. Methods aiming at the removal of the angioma : (a.) By ligation ; in telangiectasis with a broad base this must be double or multiple. A needle with a double ligature is passed through under the tumor ; one ligature is tied to one side, the other to the other side of the base of the tumor. (b.) In vaccinating on the tumor, so that, when the vaccine scab falls, the tumor may be removed. 644 TUMORS. (c. ) Cauterization ; for this purpose fuming- nitric acid is best ; it should be applied by a rod about as thick as a goose-quill, till the angioma assumes a yellowish-green color. (cL) By extirpation with the scissors or knife. After some experience in operating, the choice of these methods in any given case is not difficult. In superficial angiomata, if not al- together too extensive, and not so situated, that the subsequent cica- tricial contraction would cause decided deformity, as on some parts of the face, I regard cauterization with fuming nitric acid as the proper method. In extensive plexiform, and in the cavernous angiomata, re- moval with the knife and scissors is the most certain operation. Too profuse haemorrhages in such operations may be prevented partly by compression of the parts around by skilled assistants, and the rapid application of the suture, partly by free mediate ligation of the whole periphery of the tumor. In many eases of angioma of the face also extirpation is to be preferred to cauterization, because the incision may be so directed that the subsequent cicatricial contraction shall induce no distortion of the eyelids or angle of the mouth. But there are cases where extirpation is entirely impracticable, partly from the size, partly from the seat or number of such tumors. I treated a child, with a still growing cavernous tumor which extended from the glabella, through the nose and whole upper lip. If it had been de- sired to extirpate this, it would have been necessary to remove the whole nose and upper lip ; of course, this was not to be thought of ; hence I tried cauterization with heated needles. The treatment had lasted three months, and would have taken as much longer, although a large part of the cavernous space was already obliterated, when the mother of the child unfortunately lost patience, and I never saw it again. I prefer this mode of cauterization to the injection of liquor ferri, as suppuration and gangrene occasionally follow the latter, and as the injection is occasionally rendered difficult by the fine canula being stopped by coagula. The other methods are of very secondary importance ; vaccination frequently does not go deep enough, and the ligature is a tedious, uncertain method, which is sometimes rendered dangerous by secondary Tioemorrhage- In the form of an appendix I may also mention : 1. Cavernous lymphatic tumors (lymphangioma cavernosum), a very rare form of neoplasm, which is of the same anatomical for- mation as cavernous blood-tumors, but with the difference that, in- stead of blood, there is lymph in the mesh- work. This variety of the tumor occurs congenitally in the tongue as a form of macro^los- SARCOMATA. 645 Bia (there is also a fibrous form) ; in young persons it sometimes oc- curs at different parts of the subcutaneous cellular tissue (lips, cheeks, chin, thigh). 2. JVcevus vasculosus, the so-called fire-mole ; this is a plexiform angioma of the most superficial cutaneous vessels, which ceases to grow from the moment of birth. There is no other difference be- tween fire-mole and growing angioma. I have already said that there are various combinations of hypertrophy of the skin, pigmentation, ectasia of the vessels, and formation of hair in these congenital marks. If these marks be on the face, and not too large (sometimes they im- plicate half the face), we may extirpate them partly or entirely, and subsequently make a plastic operation, or we may resort to cauteriza- tion. Some of these marks, where only the tops of the papillae are affected, may be greatly improved or even cured by a very superficial peeling of the skin. LECTURE XLVIII. 8. Sarcomata. — Anatomy : a, Granulation Sarcoma ; 5, Spindle-celled Sarcoma ; <;, Giant- celled Sarcoma ; d, Stellate Sarcoma ; e, Alveolar Sarcoma ; /, Pigmented Sarcoma. — Clinical Appearance. — Diagnosis. — Course. — Prognosis. — Mode of Infection. — Topography. — Central Osteosarcoma. — Periosteal Sarcoma. — Sarcoma of the Mam- ma, of the Salivary Glands. — 9. Lymphomata. — Anatomy. — Eelations to Leucasniia, — Treatment. 8. SAECOMATA. Over no group of tumors has there so long been uncertainty about their anatomical position and extent as about sarcoma. The old name, taken from crap%, flesh, merely meant that on section the tumor had a fleshy look ; of course, this did not make a diagnosis, as it was greatly a matter of choice what should be called flesh. The attempt to employ the name "sarcoma" solely for tumors com- posed of muscle filaments (Schuh), that is, to identify it with those tumors now called " myoma," was not popular. Subsequently the term became somewhat more definite, as it was made to include all tumors rich in cells which had no decided alveolar formation, and were not carcinomatous. It is only for the last ten years that the follow- ing histological definition has received general acceptance and has become quite common. A sarcoma is a tumor consisting of tissue be- longing to the developmental series of connective-tissue substances (connective tissue, cartilage, bone), muscles, and nerves, which, as a rule, does not go on to the formation of a perfect tissue, but to pecu- liar degenerations of the developmental forms. Some pathologists would gladly see "muscles and nerves" excluded from this definition, but when speaking of spindle-celled sarcoma I shall show why I can- 646 TUMORS. not admit this. If it is desired to term the inflammatory neoplasias m their various stages examples of sarcoma (Rindfleisch) , I assent tc it, as this definition would agree pretty well with mine. After this anatomical basis was found for " sarcoma," it soon ap- peared that it could be diagnosed, even with the naked eye, and that clinically also something could be said about the peculiar course of these tumors. As I think that the subdivisions, according to histo- logical peculiarities, are less important for the diagnosis of these tu- mors during life, and that their diagnosis, prognosis, and course, de- pend so much on their point of origin, the rapidity of their growth, etc., I prefer hereafter classing together the clinical remarks on sar- coma, and here merely considering more attentively the histology. We shall divide sarcoma into the following forms : Fig. 130, (a.) Granulation sarcoma^ round-celled sar- coma of Virchoio. This tissue is the same, or very like that of the upper layer of granulations ; it always contains chiefly small round cells, like lymph-cells ; the intercellular substance is some- times scarcely perceptible, again it is in greater quantities, and may be perfectly homogeneous, as in neuroglia ( Yirchow's glioma and giio-sarcoma), or it is slightly striated (Fig. 130), or even fibrous, or may be cedematous (as in large mammary sar- comata). Lastly, it may also be reticulate, and so approximate the tis- sue of lipoma. Fig. 131. Tissue of a granulation sarcoma. Magnified 350 diameters. Tissue of a trlio-sarcoma, after Yvrclxow. Magnified 350 diameters. ib.) Spindle-celled sarcoma is composed of closely-packed, usually thin, elongated spindle-cells, so-called filament-cells. Usually there SARCOMATA. 647 Fig. 132. sCV Smii is no intercellular substance, occasionally there is some ; it may be homogeneous and soft, or fibrous ; if the fibrous portion preponderates, the tumor is called fibro-sarcoma, or fibroma. Formerly this spindle- celled tissue was termed young connective tissue (tissue fibroplas- tique, JOebert) ; but from my histo- genetic investigations in the em- bryo I have long protested against this view, for spindle-celled tissue, as we usually find it in these sar- comata, does not occur in embryonal tissue at any period, not even in the tendons ; the physiological exam- ple of this tissue is young muscle and nerve tissue; these spindle- celled sarcomata would then be young myomata or neuromata. Virchow has carried the same view further, especially as far as regards fibrous uterine tumors (page 619). I protested against this view of Vir chow's, with its con- sequences, as the diagnosis is always doubtful in special cases. When a nerve contains a tumor consisting of elongated spindle- cells, whose ends terminate in fine filaments, it is very natural to re- gard it as a neuroma whose elements are not fully developed at any point. When a spindle-celled tumor is developed in muscle, and the fibre-cells show band-like forms, even fine granulation, as in the com- mencement of striation, there could be no blame for calling these tu- mors " myomata," under the idea that they were young muscle-tissue that had not gone beyond certain bounds of development. So far there is no objection to this view. But when a spindle-celled sarcoma comes in the cutis, or on the penis (where I recently saw a remark- able case), we may be very doubtful whether the case is one of young neuroma, myoma, or fibroma ; in both of these parts there are nerves, muscles, and connective tissue. If, then, there be nothing typical in the arrangement or form of the cells, and the histological mode of origin cannot be certainly determined, we must content ourselves with the term " spindle-celled sarcoma." At all events, we have to deal with a fibrous tissue, whose development has not advanced beyond the production of spindle-cells. Moreover, I think I can affirm from my observations that the course and prognosis of these tumors scarcely Tissue of a spindle-celled sarcoma. 648 TUMORS. Fig. 133. depend on their origin, but far more on their locality, rapidity of growth, consistence, and other clinical conditions. (c.) Giant-celled sarcoma is a name given by Virchow to a variety of sarcoma containing very large cells, which are partly round, partly polymorphous, and supplied with many offshoots (Fig. 133). These cells, which normally occur in the medulla of the bones of the foetus, although not so large as in tumors, have excited great astonishment by their size ; they are the largest un- formed protoplasm collections that have been seen in man ; they may contain thirty or more nuclei, and their origin from a simple cell by a series of transformations is gen- erally easily followed. These giant-cells occur in spindle-celled, as well as in fibro-sarcoma ; they occur somewhat smaller sporadically, and are also found in granulation and myxosarcomata. They are most Fig. 134. Giant-cells from a sarcoma of the lower jaw. Magnified 350 diameters. (Jiant-celled sarcoma with cysts and ossifying foci from the lower jaw. Magnified 350 diameters. frequent in the central, less so in periosteal sarcoma, but I have seen them even in muscle-sarcoma. By their size they occasionally give SARCOMATA. 649 Fig. 135. the tissue an apparently alveolar (Fig. 134) structure, and by soften- ing may lead to formation of cysts («), or may ossify (£). A peculiar formation from sarcoma, which is allied to the giant- cell, although never growing very large, may be mentioned here, In a granulation-sarcoma of the dura mater, which ac- cidentally fell into my hands, there were great num- bers of globular, multinucleated cells, which were surrounded with a membrane-like connected layer of spindle-cells (Fig. 135). I hazard no explanation of these elements, but suspect that they are associated with the formation of tufts on the cerebral mem- branes, and with tufted fibro-sarcomata, which ~Vir* choic calls brain-sand tumors (psammone), when they contain brain-sand. Possibly, these peculiar forma- tions are aborted excrescences from blood-vessels, an idea I have long cherished, and which is apparently confirmed by a recently-published observation of Arndtywho saw these spheres attached to vessels by pedicles. Wcddeyer lately showed that these and allied formations, which occur especially in intracranial tumors) start from the perithelial (adventitial) cells of cerebral vessels. The neo- plasias belonging here, but not yet sufficiently analyzed and classified, Cell-globules from a sarcoma of the dura mater. Magnified 350 diameters. Fig. 136. Fig. 131 Mucous tissue from a myxosarcoma of the scalp. Magnified 400. Mucous tissue from an adenomyxoma of the mamma. Magnified 400. 650 TUMORS. as well as the alveolar sarcomata of which we shall soon treat, often so much resemble carcinomata in their structure that they are very difficult to distinguish. According to recent observations, especially those of Sattler, what I formerly described as cylindroma, and erro- neously classed with adenoma, also belongs in this class. (d.) Net-celled sarcoma. Mucous sarcoma. (Gelatinous sarcoma of Mokitanshy.) For the offshoots from cells to develop well and be distinctly seen, there must be considerable soft intercellular substance present. Hence sarcomata with gelatinous mucous intercellular sub- stance, which contain any stellate cells, are the most beautiful. But this is not always the case. There are also granulation-sarcomataj that have a claim to be regarded as mucous or gelatinous tumors. If we should wish to class the tumors from the above groups, when they appear gelatinous, together because they contain much mucous {jiv^a)^ we may call them myxomata (Virchow), or retain their old name, collonema (X Jfuller). VirchouPs true mucous tissue (Fig. 135) undoubtedly belongs to the developmental series of the connec- tive tissues ; occasionally it also occurs in mucous granulations. But frequently also we find spindle-cells and round cells in myxoma, and, if there be at the same time any developed cartilage, the mucous tis- sue may be regarded as young or softened cartilage-tissue, which be- comes the more probable if a myoxoma contains honey-comb-like septa such as are found in chondroma. "We may use the terms myxosarcoma, myxochondroma, etc. (e.) Alveolar sarcoma. This rare form of tumor (occurring in the cutis, muscle, and bone) is very difficult to characterize anatomically ; from the size and arrangement of its cells, it may in spots so much resemble carcinoma, that I would not trust myself to decide correctly on every piece of such a tumor placed under the microscope. The cells of these elements are much larger than lymph-cells, about the size of cartilage-cells, or of moderately large flat epithelium, and usually have one or more large nuclei, with glistening nucleoli. The cells are embedded in a fibrous, or more rarely homogeneous, slightly- developed intercellular substance of exquisite alveolar type, in such a way that they lie together separately, or more rarely in groups (Figs. 138 and 139). They are most intimately connected with the fibres, and are difficult to detach from the fibrous mass. The latter two pe- culiarities are important for the histological diagnosis of " sarcoma," for they show the large cells are connective-tissue cells, not epithelial cells, as in true carcinoma-tissue. Occasionally the cellular elements of these sarcomata lie in immediate contact, without any intercellular substance; the resemblance to epithelial carcinoma may prove de- ceptive. Virchow has described and deduced this form from soft warts of the cutis. SARCOMATA. 651 Pig. 138 Alveolar sarcoma from the deltoid muscle. Mamifled 400 diameters. Alveolar sarcoma from the tibia. Magnified 4)0 diameters. (f.) Pigmentary sarcoma. Melanotic sarcoma. 3felanoma. AH these names indicate pigment formation in sarcoma. This pigment, which is usually granular, rarely diffuse, is brown or black, lies almost always in the cells, rarely in the intercellular substance. Part or the whole of the tumor may be faintly or distinctly black. Any of the above forms of sarcoma may occasionally be pigmented, but I have most frequently found this to be the case in the last form, and in the spindle-celled sarcoma. Melanomata develop most frequently in the cutis, especially of the foot and hand, but also on the head, neck, and trunk. The arrangement of the cellular elements in sarcoma depends, on the one hand, on certain directions of the fibres or fibre-cells in the tissue of the tumor ; on the other, on the form of the vascular net- work ; from these circumstances, as well as from the development of giant-cells, or similar formations, there may result an arrangement of the tissue of the tumor, scarcely distinguishable from the areolar formation formerly ascribed exclusively to carcinoma-tissue. This should not astonish you, for in cartilage also we have a type of cavi- ties with enclosed cells, and also the net-work of the lymphatic glands, which undoubtedly belong to the system of connective-tissue sub- stances, but must also be termed alveolar formations. 33 652 TUMORS. Coming now to the symptoms of sarcoma perceptible to the naked eye, we must first state that in most cases these neoplasias have a roundish, sharply-bounded form, indeed, are usually distinctly encap- sulated ; this is a very important distinguishing mark from infiltrated carcinoma. Sarcoma very rarely appears on surfaces (whether free or sac-like membranes) in a papillary or polypous form ; still, there are non-glandular nasal and uterine polypi, also soft warts on the skin and mucous membrane, which, from their histological structure, can only be classed among the sarcomata. The consistence and color of sarcomata vary so much that nothing general can be said about them ; they may be as hard as cartilage, or of gelatinous, nearly fluid consistence. On incision, the tumor may appear bright red, white, yellowish, brown, gray, black, dark red, and different shades of all these colors may appear on the same cut surface, apart from the pig- mentation ; this depends especially on their vascularity, and on more or less recent extravasations of blood in the tumor. The vascularity varies greatly ; sometimes there is only a scanty net-work of vessels ; again, the tumor is like a sponge, traversed by cavernous veins. "We must here mention another peculiarity of sarcoma : it is occasionally so white that, if it be soft at the same time, it greatly resembles brain-matter. This medullary sarcoma (encephaloid) usually has all the malignant qualities of sarcoma in the highest grade, and is much feared ; it may have any of the above-described histological charac- ters. Tumors which may be torn up into bundles in certain directions have been called sarcoma fasciculatum (formerly carcinoma fascicu- latum). The anatomical metamorphoses that take place in sarcoma are various : the different modes of softening predominate ; mucous softening, even to the formation of mucous cysts, fatty and cheesy degenerations, are frequent. Ossification is very common in sarco- mata connected with bone, and may go on until the w r hole tumor is more or less completely transformed to bone. Cicatricial shrinkage scarcely ever occurs in sarcoma ; this is another important difference from carcinoma. Ulceration from within outward, opening out like a crater, is rare ; sarcomata of the cutis ulcerate early, without, however, causing extensive destruction ; ulceration of hard sarcomata occasion- ally produces well-developed granulations. The diagnosis of sarcoma during life is made by attending to the following points: Sarcomata develop with peculiar frequency after precedent local irritations, especially after injuries ; cicatrices, also, are not unfrequently the seat of these tumors ; black sarcomata may come from irritated moles. Skin, muscles, nerves, bone, periosteum, and, more rarely, glands (among these the mamma most frequently), are the seats of these tumors. Sarcomata are rarest in children, rare SARCOMATA. 653 between ten and twenty years, most frequent in middle life, and rarer again in old age. According to my observation, men and women are affected with equal frequency. If these tumors be not located in or on nerve-trunks, they are usually painless till they break out. If the sarcoma be in the subcutaneous cellular tissue or in the breast, it may be felt as an encapsulated movable tumor. The growth is some- times rapid, sometimes slow ; the consistence varies, so that it can scarcely be used as a point in diagnosis. Course and progiiosis. A sarcoma may develop solitarily, may remain so, and never return after operation. It may develop as soli- tary or multiple, and return after repeated extirpation ; metastatic tumors may form in the lungs or liver, and thus this disease may cause death in three months. You see that the greatest benignity and greatest malignity may be united in this one group of neoplasia ; in- deed, I can assure you that two sarcomata of the most similar histo- logical qualities (usually, however, with different consistence) may differ entirely in course. From this circumstance the greatest objec- tions have been made to pathological histology ; it must be acknowl- edged that the histological structure of a tumor by no means corre- sponds to its clinical course ; but for this reason to cast a slur on anatomy would be just as strange as to blame it because we cannot certainly distinguish between the microscopic preparations of a sali- vary, lachrymal, or mucous gland, although they play very different parts in the organism. We must first overcome the habit of seeking specific anatomical forms for specific functions. But there is no lack of indications for prognosis in regard to any sarcoma. We shall hereafter speak of the importance in this respect of the location of the tumor ; the consistence is important, firm sarcomata are of better prognosis than soft ones ; alveolar forms are of especially bad prognosis, and still more so are the soft granulation and spindle-celled sarcomata, which usually appear in the medullary form ; black sarcomata are also especially dangerous, the firm ones being less rapid in their course than the soft. The rapidity of the growth first appearing is very impor- tant for the prognosis ; this is, moreover, in proportion to the consist- ence ; if a sarcoma has taken four or five years to attain the size of a hen's egg, the prognosis is not so bad ; if in four or five weeks it has grown to the size of a fist, it is very bad. A sarcoma may be mis- taken for a cold abscess ; I know of one case where a sarcoma of the abdominal walls developed so rapidly that at first it was diagnosed to be furuncle. In a few months the patient was covered with sarco- mata, and, in less than three months from the development of the first tumor, she died from the disease attacking the lungs. Sometimes, however, a slowly-growinf firm sarcoma is followed by one of rapid 654 TUMORS. growth, but the reverse of this never occurs. Usually, sarcomata develop in strong, well-nourished, often in particularly healthy and fat- persons ; I saw a medullary sarcoma of the mamma in a blooming, strong, healthy girl eighteen years old ; she died of sarcoma of the lungs a few months after operation. The mode of development of sarcomata which appear successively is very characteristic. The first tumor is completely extirpated ; after a time, in, under, or near the cicatrix, a new tumor appears ; this also is completely removed ; again, a new tumor appears at the point of operation, or at a slight distance from it, and near it other new ones ; the patient begins to emaciate ; possibly further operations are not practicable, marasmus occurs, pos- sibly lung or liver tumors, with their symptoms, develop ; the patient dies from suppuration from the primary tumor, or from disease of in- ternal organs. The course just described differs from that of carci- noma, because in the latter continuous recurrence is the most frequent, while in sarcoma the regional predominates, provided the tumor has been entirely extirpated. This may readily be explained by the fact that the bounds of infiltrated carcinoma are much more difficult to determine than are those of encapsulated sarcoma : hence, ceteris pari- bus^ the latter may be more certainly removed ; if portions of sar- coma be left, of course there will be continuous recurrence. After complete extirpation of sarcoma, years may elapse before the regional recurrence, and sarcoma may always remain a local trouble for years, possibly till death. I know one case of fibro-sarcoma of the back of the head, where it was twenty-three years from the development of the first tumor till death from recurring tumors ; meantime, the patient was operated on five times, and, on each occasion, he was cured for some time. From an old woman I extirpated a medullary sarcoma (alveolar cancerous form, Fig. 138) from the deltoid muscle ; the wound had scarcely healed when a new sarcoma, like the first, formed in it ; now the woman remained perfectly well four years, then a new tumor came in the deltoid ; it was removed by an operation, probably imperfect, and recurred in the incomplete cicatrix ; exarticulation of the arm was followed by recurrence in the pectoral and latissimus muscles, and death from sarcoma of the lungs and pleurisy. A year since, I extir- pated a melanotic, large-celled sarcoma from the scalp of an old man, from whom Schuh had, six years previously, removed a similar tumor; up to the present time there has been no recurrence. When we am- putate the thigh for sarcoma of the leg, after years it may recur in the amputation-cicatrix, and be followed by sarcoma of the lungs. The local tendency to recur could be explained by an extensive sprinkling of seed in the vicinity of a tumor, if the recurrences succeeded each other rapidly, but, when years elapse between the recurrences, this ex- SARCOMATA. 655 planation will hardly answer, for it is not very probable that tumor cells would lie quiet in the tissue for years, and then suddenly shoot out like an old seed. I know no explanation for this mode of recur- rence. The course of the infection is very peculiar in sarcoma ; I think I was one of the first to show that it is an essential peculiarity of sar- coma, that it does not attack the lymphatic glands, or does so quite late in the disease. The course of sarcoma-infection goes chiefly, if not exclusively, through the veins — not, as in carcinoma, through the lymphatic vessels. Sarcomata of the lungs are mostly of embolic origin ; it seems that the walls of the veins in sarcoma are very readily traversed by the tumor-substance, and their calibre filled with friable masses of it, which thence pass into the lungs. The number of the secondary sarcomata is often enormous, the whole pleura and peri- tonaeum may be covered with them. In this respect, the melanotic forms almost appear to dispute the precedence with the medullary. Primary, only partially-pigmented tumors are occasionally followed Fig. 140. Fig. 141. Central osteosarcoma of the ulna, from the collection of the surgical clinic of the University at Berlin. Section of Fig. 1 10. by perfectly black and also by perfectly white seconda^ tumors. Sar- comata of the lungs are almost always of the granulation variety. Id 656 TUMORS. the liver I have seen secondary, very beautifully pigmented, spindle- celled sarcomata ; the forms of primary and. secondary sarcomata thus vary greatly. Topography of sarcoma. As the above general remarks are in- sufficient for practice, we must study more accurately different fores of sarcoma in certain tissues and in certain parts of the body. Sarcomata occur quite often in hollow bones (myeloid tumors or central osteosarcoma), usually in the form of giant-celled sarcoma ; they especially attack the lower jaw, next the tibia, radius, and ulna (Figs. 140 to 143). These tumors often contain mucous cysts and spherical or branched osseous formations; they are circumscribed nodules, mostly forming in the medullary cavity, which gradually de- stroy the bone, but in such a way that new bone is constantly devel- oped from the periosteum, so that the tumor, even if very large, often remains covered entirely or partially by a shell of bone ; the diseased Fig. 142. Fig. 143. Central osteosarcoma of the lower jaw of a girl nine years old. Section of the specimen shown in Fig. 141. bone then appears puffed up like a bladder, and the tumor does not always cause a complete solution of its continuity. When these sar- comata occur in the lower extremity, they become very vascular ; numbers of small traumatic aneurisms develop in them, and a true aneurismal murmur may be heard in them, so that they are often con- sidered and described as true bone-aneurisms. The cystosarcomata and compound cysts, which are occasionally seen in bones, especially in the lower jaw, also in large hollow bones, have usually developed from osteosarcomata (Fig. 144). Central osteosarcomata are usually solitary, very rarely generally infectious. In the lower or upper jaw they are apt to come at the time of the second dentition, rarely at the first : in the long bones I have only seen them at middle age ; of the tumors called epulis (the word means located on the gums) a SARCOMATA. 657 Fig. 144. large number belong to these giant-celled sarcomata ; their location on the gums is generally only apparent ; they usually spring from cavities in the teeth, and have started from carious roots of teeth. Some also call epithelial cancer epulis ; it is well either not to use such terms or to restrict them by certain adjectives ; as sarcomatous, fibrous, carcinomatous epulis, etc. Peripheral osteosarcomata or peri- osteal sarcomata (osteoid-chondro- mata of Virchow) are quite ma- lignant; they either have granula- tion structure with osteoid tissue as in osteophites, and are partly ossified ; or they are very large- celled myxosarcomata, also part- ly ossified. The rapidity of the course varies greatly; sarcomata of the lungs have been observed after them. Spindle-celled sarcomata are found especially often in muscles, fasciae, and cutis ; they are locally very infectious, and often return after extirpation. Myxosarcomata come in the cutis and subcutaneous cellular tissue, and with the naked eye are often difficult to distin- guish from cedematous soft fibromata, often the seat of multiple sarcoma, tumors have grown, and the more " medullary " their appearance, the more dangerous they are. I find that all ages, except perhaps child- hood, are equally disposed to these tumors. When sarcoma develops in a gland it almost always contains glan- dular elements, which may be greatly changed in form, and some of which may be newly formed. Hence, pure adenomata (which are very rare) may be difficult to distinguish from sarcomata that have de- veloped in glands (adeno-sarcomata). Glands are by no means equally disposed to the development of sarcoma ; we shall briefly state the localities where they are most frequently found. The female mamma, more than any other gland, is subject to these tumors. Sarcomata of the mamma are roundish, lobular, nodulated 42 Compound cystoma of the thigh, after I'ean. The nerves also art, relatively The more rapidly the primary TUMORS. Fia. 1-15. Fig. 146. Periosteal sarcoma of the tibia from a boy, from the collection at the surgical clinic of the University at Berlin. Section of Pig. 146. tumors of firm, elastic consistence ; the disease may attack a large or small portion of the lobes of the gland ; as a rule, only one breast is attacked and only at one point; at other times, several small nodules occur at the same time in one gland. These tumors grow very slowly. cause no pain ; like all sarcomata, they are sharply bounded from the healthy parts, hence they are movable in the glandular parenchyma ; when they grow large (in the course of years they may attain the size of a man's head) they almost always form cystosarcomata ; in the course of time they become softer and cause pain ; ulceration also occurs. The anatomy of these tumors has always excited great inter- est. As the glandular elements, acini as well as excretory ducts, were found in them, it was formerly supposed that they had developed in the tumor ; hence these tumors were called partial hypertrophies of the mamma. I consider this view incorrect, and think that, by ex- amining a great many of these tumors, I have satisfied myself that pri- marily and chiefly there is a development of sarcoma in the connective tissue around the acini, the latter being preserved, although they may be changed in various ways. The distention of the gland-ducts causes cysts, at first slit-shaped, subsequently more roundish, with muco- SARCOMATA. 659 serous contents, whose development we shall immediately follow. The tissue of the neoplasia itself is usually composed of small, round, spindle-shaped, rarely of branched cells, with considerable developed, fibrous, sometimes gelatinous intercellular substance. In some of these tumors the fibrous tissue may be so prevalent that, in consist- ence and constitution, the entire tumor may resemble fibroma. Acci- dental cartilaginous and osseous tissue are occasionally observed, but are very rare, and have no influence on the course of the disease. If the growth of these tumors were regular throughout, the excretory ducts and acini of the glands would be equally enlarged or compressed ; for, if you imagine a part of the gland, say a lobule, spread out as a surface, and suppose the basis to which this surface is attached en- larging, the epithelial surface must also enlarge. But the glands may be regarded as surfaces bulged out in many places, so that this representation is quite proper. Such a regular growth in all parts of a gland never or very rarely occurs ; the result is, that frequently only the excretory ducts elongate or enlarge much ; this induces the slit- shaped, elongated cysts, visible to the naked eye ; but, by simultane- ous distention of the glandular acini, roundish cysts are often formed. In this stretching of the sacculated glandular surface, the epithelium increases and develops to a higher stage, inasmuch as the small, round epithelial cells of the acini increase greatly, and change to a layered- cylindrical epithelium. The glandular substance thus altered secretes a muco-serous liquid, a very minute portion of which is spontaneously evacuated from the nipple, while most of it is retained in the tumor, and serves to dilate the already distended glandular cavity (retention and secretion cysts). Then the tumor-substance again grows into these cysts in the form of lobulated, leaf-like proliferations (cystosarcoma phyllodes, prolife- rum ; John Muller), so that the cut surface may thus acquire quite a complicated appearance. The relation of this cyst-development to the sarcoma (the nature and course of the disease is not much influenced by the former) varies greatly in these, as in all cystosarcomata. Mammary and cysto sarcomata are not very rare, but are far less frequent than the cancers of the breast, which we shall hereafter men- tion. The disease is most frequent in young married women, but also occurs shortly before puberty — rarely after the fortieth year of life. The growth of these tumors is very slow, and is painless before they become large ; later, however, they are accompanied by piercing pains ; as the tumor may grow as large as a man's head, and ulcerate, it may prove very troublesome. Some of these sarcomata have the peculiarity of swelling, and becoming slightly painful shortly before 660 TUMORS. and during menstruation. In this disease, the general health is not affected, except that in large ulcerated tumors the patients emaciate, become anaemic, and acquire a suffering look. The course of the dis- Fig. 147. From an adeno-sarcoma of the female breast : a, dilatation of the excretory ducts; 5, of the acini, magnified 60 diameters ; c, a dilated acinus of the mammary gland, with cylindrical epithelium ; intermediate substance resembling granulation-tissue, magnified 350 diameters. ease may vary ; there are not a few cases where small sarcomata of the breast, which perhaps came after the first confinement, spontane- ously disappeared in the course of time, or else remained for the rest of life without doing any harm ; but in most cases these tumors grow gradually, until they are operated for ; if this is not done till late, when the tumors have become large, and the women have attained old age, they may become infectious. In young girls and women, when a slowly-growing sarcoma of the mammary gland is extirpated, it does not usually reappear. If, however, the sarcoma first appears between the thirtieth and fortieth years, we have to fear general sarcoma infec- tion, or actual transformation to carcinoma by epithelial proliferation, I consider it advisable, in all cases, to extirpate these mammary sar- SARCOMATA. 661 comata early, as we never know exactly what their future course will be. The diagnosis is often difficult; small, nodular, lobulated hard- enings may occur in the breasts from chronic inflammation, especially during and after lactation, which pass off spontaneously, or under the use of iodine. We often have to decide from the course whether the case is one of chronic inflammation which may subside, or an actual tumor. Even the most accurate anatomical examination is here of no avail, for young sarcoma-tissue cannot be distinguished from inflam- matory neoplasia. This is another case where the boundary between chronic inflammatory neoplasias and tumors cannot be accurately drawn. A second organ, in which adeno-sarcoma and adenoma develop, is the salivary gland. The tumors that form here are usually quite firm and elastic, are tolerably movable and grow very slowly ; they occur in the parotid more frequently than in the sub-maxillary gland, and very rarely in the sublingual. As seen by the naked eye, the anatomi- cal characteristics vary greatly ; the tumor is always distinctly bounded by a capsule, which is very intimately connected with the gland-tissue. The substance of the tumor may be of pulpy, cartilaginous or fibrous consistence, it may be ossified, or calcified ; it often contains cysts of briny, gelatinous, or serous fluid. Histological examination of these tumors shows that their softer parts consist of spindle-cells and stellate cells, sometimes with a slight, again, with a large amount of mucous or cartilaginous intercellular substance ; there are also newly-formed gland-tubes. In rare cases, the tumor consists almost exclusively of cartilage, but very frequently there is some sarcomatous tissue present. These tumors may develop from the time of puberty to the fortieth year ; they grow very slowly and painlessly, and particularly slowly when they do not form till middle age. Although they never retro- grade, small tumors (say as large as an egg) of this variety may cease growing late in life. If these tumors be extirpated from young pa- tients, as a rule, they do not return. But later in life they often recur after extirpation, and return so quickly, that they gradually grow deeper in the neck, and finally become inaccessible to the knife ; the neighboring lymphatic glands of the neck are infected, and the disease assumes the character of carcinoma ; the adeno-sarcoma becomes cancer of the gland. General development of sarcoma scarce!) 7 takes place from these tumors. From the course above described, we might form the rule of removing these tumors early in young patients, but in older ones of not being too hasty about extirpation, as rapid recurrence is to be feared, while occasionally the primary tumors grow slowly. Sar- Domata of the salivary gland are not frequent. Similar myxo-sarco- mata and myxo-chondromata occasionally develop in the oral mucous membrane. 662 TUMORS. 9.— LYMPHOHATA. These neoplasias are very difficult to define accurately. According to the mode of development we may assume a secondary inflammatory swelling of the lymph-glands from infection, and an idiopathic hyper« plasia. In diseases from the most varied causes, the lymphatic glands almost always present a similar appearance ; they are enlarged, more succulent, firmer than normal. The microscopic examination of lym- phoma shows the following appearances, if made from a hardened, properly-prepared specimen : All the cellular elements are multiplied and enlarged ; the lymph-cells in the alveoli, the connective-tissue cells of the trabecular, the capsules of the alveoli and the net-work ; thus, the structure of the gland is gradually lost entirely ; the whole organ becomes a mass of lymph-cells, although a fine net-work is gen- erally preserved, into which the hard connective tissue of the capsule and of the trabecular is also transformed, while the blood-vessels are preserved, and their walls greatly thickened (Fig. 148) ; the cellular infiltration may be so great, that an exact distinction between lym- phoma and glio-sarcoma (Fig. 148) may be impossible at some points. Usually there are glands of various sizes, and we find the large ones of the same structure as the smaller. Neither the macroscopic nor microscopic appearances will determine exactly the causes of the hyperplasia, whether it be idiopathic or due to chronic inflammation ; we can only say, in general, that glands much enlarged by chronic inflammation more frequently contain abscesses and caseous foci than those which are apparently idiopathic hyperplasia. Perhaps I am too conscientious in using the term " idiopathic disease of the lymphatic glands ; " for in many of these cases we can discover no peripheral irri- tation, although many things speak in favor of the disease of the glands being secondary ; it is possible that slight, temporary inflam- mations have existed, that have excited disease of the glands, and have disappeared before the affection of the glands has shown itself. We formerly spoke of a similar secondary plastic process in the lym- phatic glands, after the primary peripheral irritation had ceased, as being a chief symptom of scrofula ; hence we might term Iymphomata as typical scrofulous tumors (scrofulous sarcoma, JB. vo)i Langenbecti). Let us study them further, anatomically and clinically. For a long time the glands preserve their kidney-shape till finally, as they continue to grow, this also is lost, and the adjacent glandular tumors unite to form a lobulated mass. To the naked eye, the extir- pated tumors appear roundish, oval, or kidney-shaped ; on section, they are of a light, grayish-yellow color, which, on exposure, changes LYMPHOMA T A. Fig. 148. 663 From the cortical layer of a hyperplastic cervical lymphatic gland. Magnified 850 diameters, a a, section of vessels with thickened walls, brushed-out alcohol preparation. to a yellowish-red. These tumors are firm and elastic ; they are easily diagnosed, from their locality. All lymphatic glands are not equally disposed to this disease ; the most frequently affected are the cervical either on one or both sides ; more rarely the axillary and inguinal, most rarely the abdominal and bronchial. These tumors are hardly ever congenital, but they may occur from the first to the sixtieth year, although they are most frequent between the eighth and twentieth. Not unfrequently, hyperplasia of the lymphatic glands is multiple ; but only one or a few glands in the neck may be affected ; if this be the case, the tendency to such neoplasia runs out in the course of time, while the tumors which have grown painlessly, and continued free from pain, have their growth arrested, and may be carried till death. In rare cases, the new formation appears almost at the same time in all the lymphatic glands of one or both sides of the neck, so that the latter is thickened, and the movements of the head are much impeded ; if these tumors continue to grow, they finally compress the trachea and cause death by suffocation ; but even in these severe casea there is occasionally a spontaneous arrest of the disease, and then even large tumors of this kind may be successfully extirpated ; some of these glands, too, are finally destroyed by ulceration and caseous de- generation. The worst cases are those where the tumors quickly grow to large medullary tumors (not unfrequently under the form of fasciculated medullary fungi), and where the neighboring tissue is also changed to lymphoma. Patients with such tumors rarely escape ; anaemia comes on, the nutrition is impaired, and hypertrophy of the spleen may appear, and the patient die of excessive anasmia and marasmus. These malignant lymph omata, which Lucke calls lympho-sarcomata^ cannot be anatomically distinguished from the benignant forms. But they 63 4 TUMORS. may be recognized from the fact that they proliferate rapidly, and especially that they unite with the parts immediately around. It seems to me they are certain to recur, and are the most dangerous of tumors. Quite recently I saw two cases where autopsy revealed me- tastatic lymphomata in the lungs and spleen. In some of these cases of lymphoma, typical leucocythemia has been observed, and Virchow thinks that in these cases the increase of white corpuscles in the blood is due to the excess supplied by the hyperplastic lymphatic glands. I do not entirely share this view, first, because even with extensive tumors of the lymphatic glands leucocy- themia is rare, and secondly, because it is very improbable that, when their normal formation is entirely destroyed, the lymphatic glands should continue their functions physiologically, or even in excess. As Frey, 0. Weber, and myself, have made a number of unsuccessful attempts to inject the lymph-vessels of such glands, this also would favor the view that these hypertrophic lymphatic glands are physio- logically insufficient, although in lymphatic glands especially such negative results at injection are to be very carefully judged. The fact that Muller (in Jena) succeeded in injecting a small, slightly- swollen gland, of course proves nothing, as the destruction of the lymph-ducts only comes on gradually. However, the interesting fact, that leucocythemia occurs especially with enlargement of the lymphatic glands and spleen, is not to be denied, only the connection is not so direct, there must be some other cause at present unknown, for the development of this disease. 34 What has been said shows that the prognosis of lymphoma varies, and can only be pronounced with any certainty after a period of ob- servation of the rapidity of its growth ; in general terms, we may say the disease is the more dangerous the younger the patient. I have rarely seen it develop after the thirtieth year, and formerly thought it hardly occurred after that ; but not long since I met a case of large lymphoma of the bronchial glands in a stout woman, forty-five years old, who had suffered for five years from asthma ; the disease had finally induced suffocation. In another case, in a man sixty-five years old, there was immense lymphoma of the axillary glands. 36 The treatment of this disease of the lymphatic glands will at first often be internal, usually antiscrofulous — cod-liver oil, brine-baths, and, if the constitution of the patient does not contraindicate it, iodine remedies ; if there be considerable anaemia, iron alone, or with iodine, is indicated. In favorable cases, recent lymphomata disappear under this treatment. In still other favorable cases, we arrest the growth of the tumor ; but, unfortunately, the number of cases curable by med- cine is slight, and in those very cases, where we wish most from these LYMPHOMATA. 665 miernal remedies, because the tumors are too large for operation, they often fail entirely ; indeed, I have even observed injurious effects from energetic iodine treatment in rapidly-growing tumors of this variety, in the shape of rapid softening of the larger part of the tu- mor, accompanied by severe febrile symptoms. Lucke made paren- chymatous injections of tincture of iodine with good results ; under this treatment I have seen small abscesses and insignificant contrac- tions occur, but no entire disappearance of the tumor. My experi- ence with the constant current has been about the same. Of external remedies also, iodine is the most effective, mercury scarcely at all so. Favorable results have also been attained by JBaum from compression with apparatus prepared for the special cases. I have thus caused im- provement ; occasionally, a slight diminution, or partial suppuration, but never perfect cure. We can only expect a cure from operation in those cases where the disease of the glands has run its course. It is true that, when these tumors lie very close to the trachea, we are oc- casionally obliged to operate on them when in full growth, but we must then always expect local recurrence or disease of other groups of glands. A careful consideration of all the circumstances must de- termine in any given case whether an operation will probably be suc- cessful. The operation itself will be well borne in cases where the glands may be isolated, and still preserve their capsules. I have ex- tirpated (or rather dug out with my finger) twenty or more isolated glands from the neck of the same patient without subsequent recur- rence ; but when the glands unite to one mass, and are soft, it is on the one hand a sign of rapid growth, and local recurrence may be cer- tainly expected ; on the other hand, it will greatly increase the diffi- culty of operation. Sometimes lymphomata, developing deep in the neck in young, otherwise healthy persons, grow behind the jaw into the throat and implicate the tonsils and pharynx ; they usually soon prove fatal ; the operations that might relieve them are so dangerous that they rarely prolong life. Of the other glands, which, according to recent observations, are to be classed in the lymphatic-gland system, the tonsils alone are subject to hyperplastic disease ; but this hypertrophy of the tonsils which is common, and in children and young persons is quite fre- quent, more resembles chronic inflammatory secondary swelling of the lymphatic glands ; it is usually the result of chronic catarrh of the pharynx, while the reverse is often falsely considered to be the case, namely, that the hypertrophied tonsils are the cause of the pharyngeal catarrh ; hence, in such cases, extirpation does nothing for the chief trouble, the frequent inflammations of the throat. 666 TUMORS. Hypertrophy of the thymus gland does occur, but is rare. The analogous diseases of Peyer's glands and the spleen have no special interest in surgery. Lymphoma also occurs in tissues which do not belong to the lym- phatic glands. I class as lymphomata all those medullary tumors, usually soft, in which, by hardening and preparation, we may see a net-work analogous to that of the lymphatic glands. In this sense, I have seen lymphomata of the upper jaw, scapula, cellular tissue, eye, etc. ; tumors whose structure frequently can only be imperfectly dis- tinguished from granulation sarcoma (especially from Virchoufs glio- sarcoma), and which form their ordinary medullary consistency, are briefly called " medullary fungi." According to my experience, the mixture of the above forms has no special prognostic significance, as these tumors are alike malignant and infectious ; but the importance of the most accurate examination of these tumors should not on this account be limited or undervalued ; during the last ten years we have learned interesting and important clinical differences for the more ac- curate distinction between sarcoma and carcinoma. Ten years ago we could not have spoken as decidedly about sarcoma and lymphoma as we now may. What we now include under " lymphomata " were formerly treated of partly under glandular hyperplasias, partly as sar- comata, partly as medullary fungi. LECTURE XLIX. 10. PapUlomata. — 11. Adenomata. — 12. Cysts and Cystomata. — Follicular Cysts of the Skin and Mucous Membranes. — Neoplastic Cysts. — Cysts of the Thyroid Gland. — Ovarian Cysts. — Blood-Cysts. 10. PAPILLOMATA— PAPILLAEY HYPEETEOPHY. Hitherto we have spoken exclusively of new formations from the series of connective-tissue substances, muscles and nerves. "We now pass to the neoplasias of true epithelium, derived from the upper and lower germ-layer of the embryo. The epitheliums form a great part of two normal tissues, namely, of the papillae (tufts, intestinal villi), and of the glands; the former are wavy or finger-like elevations, the latter pouched or cylindrical sinkings in of the membranes, which the epithelial covering accurately follows. Both give the physiological paradigms for certain forms of tumors, of which we shall mention the purely hyperplastic forms of the first series, papilloma, and those of the second series, adenoma, LYMPHOMATA, PAPILLOMATA. 607 Both are accompanied by corresponding connective-tissue and vas- cular neoplasia. Horny papillomata come exclusively in the cutis, rarely in the walls of sebaceous cysts. We may distinguish two chief forms : (a.) Warts. Anatomically these consist of an excessive growth in length and thickness of the papillae. The epidermis on these abnor- mally large papillae homines in the form of small rods, of which every wart is composed, as you may readily see with the naked eye (Fig. 149). These warts which, without any known cause, appear espe- cially often on the hands in great numbers, are rarely larger than len- tils or peas. Fig. 149. Wart: a, longitudinal section : b, cross section. Magnified 20 diameters. (b.) Horny excrescences are to some extent large warts ; the epi- dermis of the enlarged papillae adheres to a firm substance, which in- creases enormously, so that the horn, whether it be straight or twisted, may grow to three or four inches or more. Although externally these horns greatly resemble those of some animals, their anatomical struct- ure is different, for the latter always have a basis of bone. Horny excrescences are of a dirtj'-brown color ; they occur chiefly on the face and scalp, but may also come on the penis and other parts of the body, and occasionally they grow from atheroma-cysts. The development of warts and horny excrescences is evidently due to a general tendency of the skin that way. This is chiefly evident from the fact that as many as twenty or thirty warts often occur on the hands, especially of children shortly before puberty. Irritating ex- ternal influences, affecting the hands particularly, apparently combine with the fact that the epidermis on the hands is normally very thick 068 TUMORS. The tendency to horny excrescence, rare as it is, rather belongs to ad- vanced age, just as most of the other epidermoid neoplasia?, of which we shall hereafter speak. Anatomically, hystricismus would also be- long to the above forms of horny growths. Hystricismus , or porcupine- disease of the skin, is a peculiar variety of papillary hypertrophy, with hornifying of the epidermis of such a nature that porcupine-like formations develop on the cutis. Like ichthyosis (a scaly thickening of the epidermis over the whole body), this affection is mostly congen- ital ; but I have seen analogous formations in some forms of elephan- tiasis nostras. The predisposition to warts is entirely devoid of danger, and in many cases ceases spontaneously. Popularly, warts are considered contagious, possibly not altogether without reason. I saw a case where an ordinary wart formed on the side of a toe, and, on the part of the neighboring toe lying in contact with it, another wart formed. Horny excrescences are more important; although they occa- sionally break and fall off spontaneously, they grow again if they are not operated upon ; indeed, in some cases epithelial cancer forms at the point where a horny excrescence was located. In most cases warts may be left to themselves. As in all dis- eases that recover spontaneously in the course of time, there are numerous popular remedies : old women regard the placing of a hand covered with warts on the hand of a corpse, or rubbing it with various leaves and weeds, as sovereign remedies. If you wish to get rid of certain large warts that are peculiarly annoying to their owners, it may best be done by caustics. For this purpose I use fuming nitric acid, applying it to the wart and the next day cutting off the cauterized portion till a drop of blood flows, then repeating the cauterization. This should be continued till the wart has entirely disappeared. Horny excrescences can only be cured radically by cutting out the piece of skin on which they are located. By soft, sarcomatous papittomata, we mean those neoplasia? that have the form of papilla?, consist of soft connective or sarcomatous tissue, and are covered by an epithelial coating analogous to that of the matrix. Sarcomatous papillae (soft warts) occur rarely on the cutis, but occasionally appear congenitively on one side of the face as cock's- comb-like proliferations. The broad and also the pointed condylomata on the mucous membranes are products of syphilis and of the specific irritating pus of gonorrhoea ; we do not class them among tumors. Sarcomatous papillomata develop much more frequently on the PAPILLOMATA. 669 mucous membranes, especially on the portio vaginalis, more rarely in the rectal and nasal mucous membrane. According to the surgical nomenclature hitherto in use, they come in the category of mucous polypi. They are often complicated tumors, in which proliferation and ectasia of the glands, formation of sarcomatous intermediate sub- stance, and papilloma, all go together. They are mostly pedunculated tumors ; occasionally a large surface of mucous membrane becomes diseased at the same time. These papillomata are rarely infectious, but they occasionally recur after extirpation. The extensive papillomata that occasionally occur in the larynx in children are perhaps always of syphilitic origin. I formerly called tumors with papillary formation, which developed from vitreous mucous tissue, cylindromata ; but this formation is not so characteristic as I formerly supposed ; it occurs both in sarcomatous and carcinomatous tumors. Fibromatous and sarcomatous papillae may develop on the inner surface of cysts. 11. ADENOMATA— PAETIAL GLANDT7LAE HYPEETEOPHY. New formation of genuine, regularly-developed glands or parts of glands is not frequent, although Ave shall hereafter learn that, in cancer, incomplete development of glands is one of the most common forms of neoplasia. Although sarcoma of the mamma was often spoken of as partial hyperplasia of the gland, because glands were found in it, of late it has appeared doubtful whether gland-acini were really developed in the tumors formerly described as adenosarcoma (page 657) ; from my own observations, I must consider true adenoma of the breast as very rare ; I have only seen it once, it was then in a tubular form. Forster and others, however, describe acinous adenoma of the mamma ; on account of this rarity, not much can be said about the prognosis of these tumors, which usually remain small. They are generally con- sidered as entirely benignant ; but, on anatomical grounds, it seems to me probable that they cannot differ so much in prognosis from carcinoma. So far as my investigations go, the so-called hypertrophy of the prostate is never accompanied by development of adenoma, but onlv by ectasia of the acini and epithelial hyperplasia ; the frequently-ob- served enlargement of this gland depends essentially on diffuse or nodular myoma (page 637). The glands of the skin and some mucous membranes may also give 670 TUMORS. rise to development of adenoma and adenosarcoma ; it is said that tumors of the skin, which are to be regarded as pure adenomata, may result from the glandular epithelium, analogous to the gland-develop- ment in the foetus. Verneidl first described an adenoma of the sweat- glands. I have never observed such tumors, but do not doubt their existence, since Hindfleisch has demonstrated to me an adenoma of this variety. Those glandular formations that occur in the mucous membrane of the nose, rectum, and uterus, and wmich are embedded in a gelatinous, oedematous connective tissue, more rarely in some other form of sarcoma-tissue, are more frequent. Fig. 150. From a mucous polypus (adenoma) of the rectum of a child. Magnified 60 diameters. Tumors are thus developed which, in general terms, are called mucous polypi : sometimes they are in broad folds, sometimes nodular pedunculated tumors; they have the color and consistence of the mucous membrane whence they spring, are also covered with its epi- thelium, except only the soft polypi of the external auditory meatus ; strange to say, these are sometimes covered with ciliated epithelium. All of these mucous polypi do not contain glands ; they are usually absent from the aural polypi and the small, leaf-like proliferations of ADENOMATA. 67 1 the female urethra, the so-called urethral caruncles. The latter neo- plasise consist solely of cedematous and gelatinous connective tissue, with an epithelial covering. Most mucous polypi of the nares, large intestine, and especially of the rectum, consist to a great extent of elevated and also newly-formed glands of the mucous membrane, whose closed ends sometimes dilate to mucous cysts. Hence, in the anatomical system, according to the glands they contain, mucous polypi may be classed among pure adenoma (as rectal mucous polypi in children), among adeno-sarcomata (many nasal mucous polypi), among cedematous fibromata, or, lastly, among the myxosarcomata. The predisposition to mucous polypi reaches from infancy to the fiftieth year. In children the disease is limited to the rectum and large intes- tine, where sometimes one, sometimes several tumors of the same sort develop, but the latter occurs even oftener in adults than in children. From puberty till about the thirtieth year, it affects chiefly the nasal mucous membrane ; sometimes giving rise to single polypi, again, to proliferations in both sides of the nose ; the latter is the more frequent. Toward the thirtieth year, mucous polypi of the uterus occur ; under some circumstances they may change to cancer. In all of these polypi there is a great tendency to recurrence, especially in those of the nose, which often do not cease growing till they have been re- moved three or four times. Generally, in the course of years, the disposition to these new formations ceases spontaneously, and they cease to recur, or the smaller ones even cease to grow, as, for instance, in the uterus. Microscopic examination of these tumors may give some clew to the prognosis, inasmuch as those tumors, which consist entirely of oedematous connective tissue have far less tendency to re- cur than those which consist of tissue analogous to inflammatory new formation ; lastly, in some cases anatomical examination alone can prevent mistaking them for epithelial carcinoma. Mucous polypi of the nose are most readily removed by tearing them out with the forceps made for that purpose ; we do the same for those of the external auditory meatus [the latter may be most effectually cured by free applications of liquor ferri persulphatis] ; those of the uterus and rectum we may cut off at the base with scissors ; if we fear haemor- rhage, we may previously apply a ligature, or employ the ecraseur. Of the glands without excretory ducts we shall here consider only the thyroid, as it is a true epithelial gland ; adenoma of the ovary so often becomes cystoid in form, that it may be more suitably treated of in the next section. Tumors of the thyroid gland have long been called goitre, struma (in the middle ages " strumous " indicated what we at present call "scrofulous"). Considering the anatomical rela- 672 TUMORS. tion of these tumors to the gland, we find that there are diffuse swell ings of the gland, affecting one or both lobes, and others that are dis- tinctly bounded in the gland, the latter remaining normal or but slightly hypertrophic. If we exclude simple cysts of the thyroid, so- called struma cystica, most other forms of goitre are pure adenoma or cysto-adenoma. If the tissue of these tumors, which may vary greatly in consistence, be not metamorphosed by secondary changes, on section it appears to the naked eye almost the same as the cut surface of a normal thyroid gland. Microscopically also it is very much the same; almost all thyroid tumors on microscopic examination show a large amount of connective-tissue capsules, which contain a clear gelatinous substance filled with more or less round pale cells (Fig. 151). The Fig. 151. From an ordinary firm tumor of the thyroid— adenoma of the thyroid ; partial injection. Magnified 100 diameters. size of these varies greatly, the youngest, which as yet contain no gelatinous substance, but only cells, being analogous to the foetal thyroid vesicles, while the larger are six or ten times this size. One of the most frequent changes in goitre-tumors is the formation of cysts, which come from a number of the dilating gland-vesicles uniting, and their thick gelatinous contents becoming fluid. But, besides this formation of cysts in goitres, there are other just as frequent changes that occur almost regularly if the goitre exists a long time: these are extravasations of blood, which are mostly reabsorbed, but leave more or less pigmentation. Caseous and fatty degeneration is also frequent in old goitres ; lastly, calcareous degeneration often occurs, so that by these secondary changes the original picture of the tumor may be much altered. Goitrous tumors, which may lie in the middle of the ADENOMATA. 673 neck or to both sides, in numbers or solitary, may attain a consider- able size, compress the trachea, and cause suffocation. Much more rarely the regular double-sided hypertrophy of the thyroid attains a dangerous size. Goitre is chiefly remarkable for its endemic occur- rence ; it is found mostly in mountaineers : it is seen in the Hartz, Thuringian, Silesian, and Bohemian mountains, and in the Alps, although not equally frequent in all parts. Some valleys of Switzer- land and of the Austrian Alps are entirely free from it. It has been ascribed to the most different causes, especially to the water and soil, without any definite scientific reason having been found by accurate investigations. Undoubtedly, climatical and geological conditions have much to do with this disease. Complete similarity in the con- stitution (probably often hereditary) of goitrous patients can hardly be proved ; a certain connection with cretinism cannot be denied, in- asmuch as most cretins have goitre ; but the disease is more frequent in persons with well-developed bones and brain. Goitre may be con- genital in some rare cases, but does not usually increase till the com- mencement of puberty ; the growth rarely continues beyond the fiftieth year ; goitres which have continued harmless till then, usually cease to grow, and subsequently cause no trouble ; to this rule there are only a few exceptions, where cancerous goitre develops from the above hyperplastic form, infecting the neighboring lymphatic glands ; these almost always prove fatal by suffocation. It is scarcely necessary to consider struma aneurysmatica as a peculiar variety, as it is merely a goitre accompanied by great dilatation of the afferent arteries. Prep- arations of iodine are usually employed against this disease ; they are only efficacious, however, at the commencement; later they are almost useless ; they are, however, used both internally and externally, as we have no other remedy. Extirpation of hypertrophied thyroid glands, as well as of large goitrous tumors, is very dangerous ; it is often fol- lowed by severe haemorrhage or occasionally by sudden death from the extent of the operation, so that we should only try it in small movable goitres in young persons. Even then the operation is occasionally dangerous, and some experience is necessary to tell beforehand which tumors can be safely operated on. In general, I would warn you against performing such operations for the cosmetic effect ; if there be danger of suffocation, we may be obliged to try even doubtful opera- tions. The best chances are offered by movable goitrous tumors in the median line of the neck in young persons, while the removal of even small ones deeply embedded in the hypertrophied lateral lobes is difficult and not free from danger. Even the slightest operations of this sort must be pei formed with the greatest care, especially in regard 43 674 TUMORS. to arresting the haemorrhage from arteries and veins (by mediate liga- tion before their division) ; in detaching the encapsulated tumor it is better to use the finger, a probe, or some other blunt instrument, than the knife or scissors. 36 12. CYSTS AND CYSTOMAT A— CYSTIC TUMORS. A tumor formed by a sac filled with fluid or pulp is called a cyst or cystic tumor. It may develop from a sac already existing (cyst), or it may develop entirely new (cystoma). If the tumor be formed of a convolution of very many such cystic tumors, it is called a a com- posite cyst or cystoma." If in one of the tumors already described, or in carcinoma, we find cysts also forming an essential part of the tumor, we give them names like cysto-fibroma, cysto-sarcoma, cysto-chon- droma, cysto-carcinoma, etc. As previously stated, Virchow reckons encapsulated extravasations of blood, hagmatonia (extravasations-cysten), among the tumors, as he also does dropsical effusions and hypersecretions of serous sacs (hy- drocele, meningocele, dropsy of the joints, .ganglion, etc., exudations- cysten). According to J^irdiow, the retention-cysts form the third class of cystic tumors. Of these, we leave the retention-cysts of the large canals, such as hydrops vesicas fellas, processus vermiformis, tubarum, and of the uterus, to internal medicine and obstetrics, and confine ourselves to those tumors that Virchow has grouped under the name of follicular cysts. The glands of the skin, as well as of the mucous membrane, have a tendency to the formation of cysts. Cysts of the thyroid have a doubtful position between exudation, follicular and neoplastic cysts. Closed follicles of lymphatic glands seem never to give rise to cysts. Among the glands of the cutis, cysts develop from the sebaceous alone ; I do not know that cysts of the perspiratory glands have ever been described. The reasons for secretion collecting in the sebaceous glands are : (a) its becoming inspissated ; (h) closure of the excretory duct. If from either of these causes the secretion be retained and collect in the gland, the pouched secreting surface becomes expanded to a simple sphere ; the collected secretion exercises a mechanical irritation on the surrounding connective tissue, which consequently becomes thickened and surrounds the secretion like a vesicle. If the sac, not yet grown large, can be evacuated by strong pressure, the small open cyst is called a comedo^ or " maggot." If, from any irrita- tive inflammatory process, the excretory duct of a sebaceous gland be closed, there may be atrophy of the gland, as after a burn with very CYSTOMATA. 675 superficial destruction of the skin ; but in other cases the secretion of the gland continues, and it distends slowly to a large sac. Such cysts, filled with fatty pulp and epidermis, are called pap-bags (grutzbeutel), atheromata. On microscopic examination we find the pulp to consist of fat-drops, fat-crystals, especially cholestearine, epidermis-cells, and small plates. It has very varied color and consistence ; most athero- mata on the scalp, which develop at advanced age, contain a dirty- grayish brown, badly-smelling, pulpy, pasty, sticky substance. Other tumors of this sort, especially those that are congenital, on the fore- head, temples, or face, are filled with a milky or light-yellow pulp, which, under the microscope, shows little besides epidermis-scales and crystals of cholestearine. This form- of atheroma is called " chole- steatoma." The sacs of these cysts are usually thin, and are com- posed of connective tissue ; their inner surface is usually distinctly bounded by rete Malpighii, and is wavy, or elevated into papillae. I have found no other resemblance to cutis in these sacs, but others have found hairs and sweat-glands in them. The contents of these cysts sometimes become calcareous. Atheroma may rupture as a result of injury, or, very rarely, spontaneously ; the pulp is evacuated, the edges of the opening are everted, and the inner surface of the sac becomes a bad-looking, ulcerated surface ; except on the head and face, where they are frequent, these tumors rarely occur. In the neck, salivary ducts (closed internally and externally, but open in the middle, which are lined with epidermis) may, in the course of years, become large cholesteatomata by the deposit of epidermis. These show themselves in the mouth (as ranula), or externally on the neck above and behind the thyroid. In the mucous membranes, also, inspissation of the glandular mucus and consequent hinderance to its evacuation, may cause development of mucous cysts ; but probably the more frequent cause of retention- cysts here is closure of the excretory duct. The secretion in these glands is usually a tenacious, often thick mucus, of a honey-color (me- liceris), reddish yellow, or even chocolate-brown. On microscopical examination of the contents of the cyst, we find numerous large, pale, round cells, often containing fat-globules, in homogeneous mucus, also cholesterine crystals, often in large quantities. In the nasal mucous membrane these cysts are rare, but they occur in nasal mucous polypi, often to such an extent as to give them the name of cystic polypi. LuschTca often found small cysts in the mucous membrane of the antrum Highmori. In the oral mucous membrane they occur chiefly on the inside of the lips, more rarely on the cheeks ; they are an ordi- nary occurrence in the uterine mucous membrane and in uterine polypi. In the rectal mucous membrane, on the contrary, mucous 676 TUMORS. cysts do not occur, and they are very rare in the mucous membranes deep in the body. Neoplastic cysts. These result mostly from softening of tissue previously diseased by cell-infiltration, or of firm tumor-substance. As soon as the new formation has separated into sac and fluid con- tents, in some cases a secretion from the inner wall of the sac begins, so that the softening cyst becomes a secretion or exudation cyst, and thus grows. Any tissue rich in cells may be transformed into a cyst by mucous metamorphosis of the protoplasm, or, as others express it, by separation of the mucous substance through cells, without any connection with development of mucous glands. In the foetus, we know there is a development of cavities (i. e., the joints) by mucous softening of the cartilage-tissue. In cartilage-tissue there is often a mucous softening of certain parts, by which chondromata with mucous cysts are developed. In the same way it is not uncommon for parts to become fluid and encapsulated ; the same thing occurs in sarcoma, especially in giant-celled sarcoma. The often slit-shaped, smooth- walled cysts, with serous or sero-mucous contents which occur in uterine myomata, are possibly enormously dilated lymph-spaces. Bone-cysts always originate by softening ; the often glistening smooth membrane lining such cysts may in the course of time actually secrete. While the above varieties of neoplastic cysts have no relation to gland new formations, those we are now about to mention develop from adenoma. The cysts of the thyroid, cystic goitre, already men- tioned (page 672), have a somewhat uncertain position in this series; uncertain because they are not due to newly-formed gland follicles or ducts, but to collection of mucous secretion in one of the thyroid vesi- cles. If we term the contents of these cysts secretion, as we might do for some reasons, we must class these cysts as retention-cysts. But, as it might be urged on the other hand that it would be questionable to speak of a secretion of the thyroid gland, as some state that normally the contents of the thyroid vesicles consist solely of cells, we may also consider the cysts resulting from softening of the contents of the vesi- cles as newly formed. Whichever view we take, it is certain that the cysts of the thyroid may be solitary, and may attain great size. More- over, in almost every large, and in some small, otherwise firm goitres, one or more cysts occur ; they usually have very smooth walls. The large, isolated cysts of this variety, particularly, give the impression that they are chiefly secretion-cysts, while other similar cavities in other parts of large goitres, by their softened, ragged walls, give the impression of being softening cysts. In the thyroid gland the process of softening usually terminates in the formation of a mucous fluid ; CYSTOMATA. 677 but there are other cysts in these glands that contain a gray, friable pulp, which looks like that from sebaceous glands, but differs essen- tially from it because it contains only the detritus of thyroid tissue ; I have never seen genuine atheroma-pulp in thyroid cysts. Among the complicated cystic tumors are the cysto-sarcomata of the breast, of which we have already spoken (page 657), cystomata of the ovary and testicle, cysto-adenoma, cysto-sarcoma, and cysto- carcinoma. According to recent investigations, in the great majority of these cases there is a new development of gland follicles or ducts, from which terminal swellings become choked off, as results normally in the development of thyroid or ovarian follicles. A mucous wine- yellow, brownish-red, or dark-brown fluid is secreted in these newly- formed follicles (perhaps also in the normal ovarian follicles) ; this gradually distends the follicle, which was at first microscopic. Some- times immense ovarian tumors (distending the abdomen more than it is in the ninth month of pregnancy) may develop from such a follicle, or from the confluence of several of them to a common cavity. In other cases, hundreds or thousands of such follicles develop, forming the multilocular cystic tumors of the ovary. The latter process also occurs in the testicle, although more rarely than in the ovary. In both of these organs, as in the mamma and thyroid, the contents are mucous as a rule ; but, in the neoplastic follicular cysts of the ovary and testicles, there are occasionally secretion of fat and extensive pro- duction of epidermis ; these may remain as epithelial or epidermis pearls (cholesteatoma pearls, page 675), as big as a millet-seed or a pea, as I have seen them in tumors of the testicle, or form large cysts containing fat-pulp. The walls of these cysts, which are found the size of a child's head or larger, in the ovaries of old women, are usually more highly organized than those of cutis atheroma ; large quantities of hair, sebaceous glands, sweat-glands, papillae, even warty growths, are not unfrequently found in them. Indeed, plates of cartilage and bone, with teeth of varied form, have been found in these cysts, so as to render it probable that they were aborted foetuses from an incom- plete ovarian pregnancy. Besides occurring at the above positions, composite cysts are occa- sionally congenital about the sacrum ; they often contain ciliated epi- thelium, and, besides other tissues, they sometimes have glandular, follicular formations. The tissues in these congenital tumores coc- cygei vary from the relatively simple forms of cysto-sarcoma to the foetus infoetu, and cannot here be further entered into without going into details and fine discussion. I must lastly mention cysts containing perfectly fluid venous blood, and having smooth walls, which are here and there mentioned 678 TUMORS. in literature. Some of them refill rapidly, others more slowly, after puncture ; such cysts have been observed in the axilla, on the thorax and neck. Excluding those cases where effusions of blood have given a dark blood-color to the mucous of serous contents of a cyst, and considering only those in which there is blood alone in the cysts, they could scarcely have been any thing but large sacs on the veins or cavernous-venous tumors whose framework had been entirely atrophied. All the cases of this kind so far reported have been cured by puncture and injection with iodine, so that nothing can be said of the pathological anatomy. The diagnosis of cystic tumor is easy ; if it can be certainly pal- pated, the fluctuation will be felt; deeply-seated cysts are often diffi- cult to recognize. They may be mistaken for other encapsulated fluids ; an exploratory puncture with a very fine trocar is admissible to confirm the diagnosis, if this be necessary to determine the treat- ment. There are various things for which a cyst may be mistaken ; e. g., cold abscesses are also painless, occasionally very slowly enlar- ging, fluctuating tumors ; also cystic parasites, of which two varieties occur in the outer parts of the body, especially in the subcutaneous tissue ; cysticercus cellulosaz and echinococcus hominis, although rare, do occur in the cellular tissue (and still more rarely in bone) ; the former is a small, the latter a large vesicle, which may contain many smaller ones ; the vesicle of which the animal consists always has a neo- plastic sac around it ; as may be readily seen, the whole thing gives the impression of a cystic tumor. I have seen cysticercus vesicles removed from the tongue and nose, echinococcus vesicles removed from the back and thigh. The diagnosis of cysts was made in all the cases except in one of the latter where abscess was diagnosed, and in fact, instead of the customary encapsulation, there was suppuration around the dead echinococcus vesicle. I have introduced this as a sort of appendix, because we have nowhere else an opportunity of considering the parasites. The millions of trichinae occasionally scattered through the muscles cannot be treated surgically, even when, according to the brilliant investigations of Zenker^ the diagno- sis may be, and has been, made in many cases. Dropsies of the sub- cutaneous-mucous bursas and of the tendinous sheaths as well as spina bifida may also be readily mistaken for cystic tumors, if we do not attend to the anatomical seat of these swellings. Cystomata may also be mistaken for other gelatinous soft sarcomata and carcinomata, and for very soft fatty tumors. As stated, when an intention of oper- ating renders a certain diagnosis necessary, we make an exploratory puncture. But what guides us chiefly, in the diagnosis, is the expe- rience about the relative frequence of different tumors on different OYSTOMATA. 679 parts of the body ; I have given you the sum of these experiences in each form of cyst, and in the clinic shall hereafter direct your special attention to this point. As the above includes the prognosis of cystic tumors, all of which grow slowly when they exist as cysts without complication, we may pass at once to their treatment. We may remove cysts in two waj^s, viz. : by evacuating the contents, and locally applying remedies that may excite an inflammation which shall cause atrophy of the sac, or by extirpating the sac ; the latter is always the simplest and most rapid, and we always give it the preference where it can be done easily and without danger to life. But in cysts of the ovary, thyroid, and other glands, that are deeply seated or from other causes danger- ous, some other, safer operation is of course desirable, if it offers a prospect of success. We may induce shrinkage of the sac after pre- cedent evacuation of the contents, by a suppurative or by a milder, drier inflammation. If you slit up the wall of the cyst its whole length, and keep the cut edges apart, there will be suppuration and granulation of the exposed inner wall of the cyst, with detachment of the portions of tumor or epithelium clinging to it ; the sac then gradually shrinks up into a cicatrix, then decreases in size, and finally heals ; but this may require months. You may attain the same thing in a more subcutaneous way, by ligatures or tubes through the tumor at different points ; the irritation caused by these, as well as by the entrance of air, causes suppuration and granulation of the inner wall, and in favorable cases these may lead to atrophy ; often this does not occur in the manner desired, or else it may require months or years ; so that of these two methods the first is preferable ; it is particularly applicable to cysts of the neck. We may attain shrinkage of the cyst and drying up of its contents in another way, namely, by puncture, with subsequent injection of tincture of iodine ; we have already (page 525) said enough about the effect of this treat- ment. Here, too, the injection is followed by severe inflammation of the sac with sero-fibrinous exudation ; then the serum is reabsorbed and the sac contracts. The latter method is particularly applicable when we have to deal not with contents of softened tissue, but with a fluid secreted by the walls of the sac, that is, chiefly with cysts whose contents are serous, and some sorts of mucous cysts. Cysto- mata developed from softened gelatinous substance and fat-cysts are not suited for iodine injections ; for they are apt to be followed by severe inflammation and suppuration, with formation of gas, so that we are subsequently obliged to slit up the entire sac. And very thick walls, which contract very slowly or not at all, also contraindicate iodine injections. Hence among cysts of the neck we find some that 680 TUMOKS. are suited for this treatment, others which are not, because their walls are too thick. Of the ovarian cysts, too, unfortunately but few are suited for treatment by iodine injection, so that recently the extirpa- tion of these tumors by laparotomy is considered the only certain operative proceeding ; of late years the results from this operation have constantly been growing more favorable. Lastly, we must state that in some cases it is best to avoid any operation ; for instance, I should consider it folly to persuade an old man, with a number of atheromata on his head, to have them removed ; for, if the operation were followed by erysipelas, it might prove fatal. LECTURE L 13. Carcinomata. — Historical Eemarks. — General Description of the Anatomical Struct- ure. — Metamorphoses. — Forms. — Topography. — 1. Skin and Mucous Membranes with Pavement Epithelium. — 2. Milk Glands. — 3. Mucous Glands with Cylindrical Epithelium. — 4. Lachrymal Glands, Salivary Glands, and Prostate Glands. — 5. Thyroid Glands and Ovaries. — Treatment. — Brief Eemarks about the Diagnosis. 13. CAECINOMATA— CANCEEOUS TUMOES. To give you an idea of how tumors were formerly diagnosed, and of the origin of many of the names still in use, I will read you a pas- sage from the classical, and, in its time, most prominent, work of Lorenz Heister, the third edition of which, published in 1731, I have before me. Here (page 230) it says : " The name scirrhus is given to a painless tumor that occurs in all parts of the body, but especially in the glands, and is due to stagnation and drying of the blood in the hardened part." (Page 318) " When a scirrhus is not reabsorbed, cannot be arrested, or is not removed by time, it either spontaneously or from maltreatment becomes malignant, that is, painful and in- flamed, and then we begin to call it cancer or carcinoma y at the same time the veins swell up and distend like the feet of a crab (but this does not happen in all cases), whence the disease gets its name ; it is, in fact, one of the worst, most horrible, and most painful of dis- eases. While the skin remains intact over it, it is termed hidden (can- cer occultus), but, when the skin has opened or ulcerated, it is called open, or ulcerated cancer ; the latter usually succeeds the former." It is not long since men lived in the simple belief that there was something real and truly practical in this mode of comparison and description. In a hundred years will they laugh at our present ana- tomical and clinical definitions, as we now do at good old Heister ? Who knows ? Time moves on w T ith giant strides ; things come to CYSTOMATA, CARCINOMATA. 681 light, and, before we have time to look around, they are turned into history by the careful labors of energetic young experimenters. In the natural sciences we always dislike to give short definitions, because this is often impossible, on account of the passage of one pro- cess, or of one formation, into another. We may say that carcino- mata are very infectious tumors, and that this infection, which first attacks the lymphatic glands, afterward more distant organs, is prob- ably due to the passage of elements from the tumor (whether of cells or juice is not yet known) through the lymphatic vessels and veins into the blood. This common clinical definition of carcinoma should be controlled by the anatomical structure of these tumors. Anatomical peculiari- ties, easily recognized with the naked eye or with the microscope, are sought for. The classical monographs of Astley Cooper on diseases of the testis and breast (the latter, unfortunately, unfinished) show that, by a careful study of the points perceptible to the naked eye, a great deal may be attained by studying a single organ ; but a general- ization by aid of the anatomical preparations alone is impossible, as we have often felt, in the course of these lectures — it is frequently difficult, even with our present aids ; so that I cannot blame Virchow for try- ing, in his great work on tumors, to give most minute descriptions of the different forms of tumors at certain localities. Here, where we must express ourselves briefly, to give our descriptions an anatomical basis, we must be somewhat more decided and summary. When the naked eye no longer sufficed for the diagnosis of tumors, the aid of the microscope was invoked, and characteristic appearances were sought that might occur in the same way in all the tumors we have described. Still, whether the characteristics of the cellular elements were sought in their processes, the size of the nucleus or of the nucle- olus, the clinical and anatomical peculiarities would not always remain congruous. When the cells proved inefficacious as evidence of carci- noma, it was sought for in the general structure of the tumor ; alveo- lar formation was asserted to be the anatomical peculiarity. We even come in collision with this idea occasionally ; the net-like forma- tion of neoplastic lymphatic gland-tissue may also be termed " alveo- lar," and even acknowledging that the lymphoma net- work is so pecu- liarly characterized by its form that it may be readily excluded, there still remain some forms of chondromata and sarcomata, especially the giant-celled, and other large-celled sarcomata forms,- which we have already designated as alveolar sarcomata (pages 648 and 651), as the ghosts of cancer. Since anatomical study, especially the origin of neoplasms, has been regarded as an essential principle of division, we escape all the 682 TUHOKS. difficulties just enumerated. Now, anatomy alone decides what is to be called cancer. In the clinic we then have to investigate how can- cers of different formations and compositions usually conduct them- selves : if they be infectious or not ; whether they run their course slowly or rapidly; if they are usually solitary or multiple; where most frequent, and how they are most successfully treated. Most modern pathologists agree in calling only those tumors true carci- nomata which have a formation similar to that of true epithelial glands (not the lymphatic glands), and whose cells are mostly actual derivatives from true epithelium. I am convinced that this view will constantly have more adherents, and that thus the differences about the anatomical definition of " carcinoma " will constantly diminish. Those investigators who, during the last few years, with all the mod- ern aids, have worked without prejudice on this portion of the study of tumors, recognize the great importance of epithelial proliferation in those tumors that we call cancer, still most of them seek for a compromise between the different histogenetic views, and wish still to admit, in a modified form, the development of true glandular and epithelial cells from connective tissue (heterology proper) (Mind- fleisch, Volkmann, Klebs, Lucke) ; only Thiersch, and recently Wal- deyer, maintain, as I do, the strict boundary between epithelial and connective-tissue cells. Waldeyer defines carcinoma as an atypical epithelial neoplasm. But we must here state that in cancer-tumors, besides the epitheliums, there are usually numerous young, small round cells which, infiltrated in the connective-tissue portion of the tumor, form an important part of it. This small-celled connective-tissue in- filtration, which exists in varying quantities wherever epithelial pro- liferations grow into the tissue, appears to be caused by a sort of re- action, and to be the result of the penetration of the epithelial new formations into the tissue, according to the number of infiltrated cells and their future fate, as well as the degree of vascularity, just as in inflammation it sometimes leads to softening, to atrophy, and cicatri- cial thickening of the tissue. In some cases this small-celled infiltra- tion is so considerable as almost entirely to hide the epithelial new formation (from which it may be very difficult to distinguish, if the latter be small). We may then be in doubt if it should not be re- garded as entirely independent, and occasionally, perhaps, as the sole constituent of cancerous tumors. Formerly I myself thought it neces- sary to agree to this, and even supposed that this component of car- cinoma possessed a spontaneous power of infection ; but further ob- servations with new aids have made it appear to me more probable that, even in the smallest cancerous nodules, epithelial elements are proliferating. The epithelial cells, and the base on which they grow CARCINOMATA. 683 and from which they draw their nourishment, are most intimately connected. Many observations show certainly that the cellular infil- tration of the connective-tissue base causes an increased proliferation of the superjacent epithelium ; so it would not be difficult to suppose that the first impulse to the atypic adenoid proliferation was due to an irritative state of the epithelial base. But it is just as possible and probable that the epithelial proliferation is, as we usually con- sider it, the first formative process in the development of carcinoma. There can be no direct observation on this point ; the connective- tissue infiltration is always there as soon as the epithelial prolifera- tion ; this so much impedes investigation of the first stage, that a choice of very favorable objects (such as flat cancer of the skin) alone will give any evidence in favor of our view, while the study of more difficult objects (as infiltrated lymphatic glands) in which, during life, the most varied cells are mixed up, will find plenty of support for Virchoitfs view (which I formerly held), according to which epi- thelial cells may result from proliferation of connective-tissue cells. 37 It is especially important, anatomically, to make a distinction be- tween adenoma and carcinoma, as the two forms of tumors have some points in common. Pure adenomata are composed of newly-formed gland-substance which is entirely analogous to or at least very much like the normal ; the connective tissue around the newly-formed acini has the same relation to them as to the normal. In adeno-sarcoma there is little if any new formation of glandular acini, but the sarcoma merely encloses the glandular spaces which have remained normal, or are dilated. But it is characteristic of car- cinoma that the epithelial covering of a skin or mucous membrane, or the epithelial lining of glandular cavities, grows into the skin, and even deeper, in the form of roundish nodules (acinous), or of round cylinders or rollers (tubular), just as occurs in the foetus. While so doing, the epithelial cells usually preserve their form, only they often grow much larger than normal. The form of the glands from which these formations proceed generally remains typical for the neoplasm also ; but it remains in irregular forms of glands, it is only rarely that cavities are formed, and that, actual secretion goes on in these cavities. Besides the epithelial parts of these tumors, the connective tissue, bones, muscles, etc., into which the epithelium enters, conduct them- selves as follows : We sometimes find them of normal, again of abnor- mal firmness, sometimes very soft, almost mucous, ordinarily in less quantity than the epithelial masses. It is usually pervaded by small, round (lymph) cells, often to such an extent that scarcely any fibrous tissue is left ; generally the infiltrated small cellular elements are scat- tered diffusely in the cancerous (connective-tissue) framework; very 684 TUMORS. rarely, we find numerous cells, collected together in a fissure between the connective-tissue bundles. When the tumor advances into the bone, the latter is eaten away, as in caries. I have not been able to satisfy myself that there is any new formation of connective-tissue filaments in the nodular and infiltrated forms of these tumors, nor have I been able to find any osseous new formation; but there is no doubt that such a new formation occurs in the papillary and villous forms, of which we shall hereafter speak. From this description you see that Waldeyer's expression about the epithelial formation in carcinoma being atypical (tissu heteroadmique of Robin) is also well suited for distinguishing carcinomata from adenomata, as typical new formations. As regards the vessels in these tumors, we may satisfy ourselves, by artificial injections, that the dilatation and new formation, by tor- tuosity and looping, are considerable ; only the connective-tissue por- tions of the tumor are vascularized, the epithelial portions remain free ; this is a very important anatomical criterion, as is the fact that true epithelial cancer-cells never unite together as the large epithelio- cells of some sarcomata do ; Waldeyer has justly attached great im- portance to this latter point. I cannot go any further into the gen- eral histological description of these tumors, and hope that they may be recognizable from the above, although I acknowledge that it is sometimes very difficult to distinguish carcinoma from adeno-sarcoma and alveolar sarcoma. 38 According to my whole histogenetic view, I must regard it as im- possible for an epithelial cancer to occur primarily in a bone or lym- phatic gland. The observations that I know, to this effect (in the lower jaw, on the anterior surface of the tibia, in the lymphatic glands of the neck), do not seem to me sufficient proof, because the skin and mucous membrane are so near ; there may have been an insignificant carcinomatous disease of the skin or mucous membrane as a starting- point of the disease, without its having been noticed. The appearance of the cut surface of this tumor, and its consist- ence, vary so, that no general description can be given of it. In the great majority of cases, carcinoma appears in the form of nodules ; also as indurations of otherwise soft tissues, or as papillary proliferations. Rarely, the diseased parts are separated from the healthy tissue by a connective-tissue capsule ; but, in most cases, the passage from healthy to diseased tissue is more gradual. In some cases there is no cancerous tumor, but a cancerous infiltration, there being no enlargement, possibly even a diminution in size of the affected organ. It is also characteristic of carcinoma that part of the new formation is very short-lived, disintegrates directly or after pre- cedent fatty degeneration, is reabsorbed, and then the infiltrated CARCINOMATA. 685 fibrous tissue contracts to a firm cicatrix. Besides this cicatricial shrinking, and not unfrequently along with it, there is often softening ; it is, perhaps, even more frequent than contraction ; at all events, it is more extensive. This softening is mostly preceded by fatty degen- eration of the cells and caseous metamorphosis ; central softening, opening outwardly, formation of a putrid ulcer, with fungous edges, is very characteristic of carcinoma. Mucous metamorphosis of the cell- protoplasm also takes place in some glandular carcinomata, relatively most often in those of the liver, stomach, and rectum ; in rare cases, this also affects the connective-tissue stroma. This mucous cancer is also called gelatinous or colloid. When cancerous degenerations oc- cur on the surface, the papillary layer may develop so as to become very prominent, as in some papillary cancers (destructive papillomata) of the mucous membrane of the lips, stomach, and portio vaginalis, and as in villous cancer, which develops on the mucous membrane of the bladder, in the form of dendritic, branched, large papilla?. If the cicatricial contraction predominate in a carcinoma (as it does in some forms of cancer of the breast), hard tumors or ulcers are developed, which have for ages been called scirrhus. Some carcinomata are brown or black, but still melano-carcinomata are rare. Most soft melanomata are sarcomata. 39 You will more readily acquire an idea of the different forms of cancer by studying attentively their origin and the localities where they chiefly occur. 1. Skin (cutis) and mucous membranes with pavement-epithelium, Common epithelial carcinoma (specially so called because it was the first, and, until lately, the only form in which the main body of the cancerous tumor was known to consist of epithelium), or cancroid (cancer-like tumors ; this name was chosen because these cancers of the skin were considered less malignant than those forms observed in the breast, which were considered as the type of true cancer). The cutis is covered by a layer of epithelium, from which in the foetus there are various ingrowths into the subjacent tissue, namely, the hair-follicles, hair, sebaceous, and sweat glands. Mucous glands are formed on mu- cous membranes in the same way. Many assert that all these tissues may have epithelial outgrowths. I shall not deny^this, but epithelial ingrowths may be most readily proved in the rete Malpighii. Next to this, a considerable collection of epithelium in the sebaceous glands and glands of the oral mucous membrane, and their enlargement, are also frequently witnessed ; less frequently, the hair-follicles and sweat- glands are implicated. During this ingrowing, the young cells of the rete at first preserve their size and form ; even their relation to the connective tissue of the cutis remains the same, for those cells lying 686 TUMORS. Fio. 152. Commencing epithelial cancer of the vermilion border of the lip.— Growth of the rete Malpip-hii into the tissue of the lip.— Horny epidermis.— The blood-vessels injected. Magnified 60 diameters. Fig. 153. Flat epithelial cancer of the cheeks.— Glandular ingrowth of the rete Malpighii into the con- nective tissue, infiltrated with email cells. Magnified 400 diameters. CARCINOMATA. 687 next to the connective tissue preserve a cylindrical form, just as on the normal papilhe of the cutis. It is very probable that the epithelial, gland-like ingrowths not un- frequently grow into the spaces between the connective-tissue bun- Pio. 154. Elements of an epithelial carcinoma of the lip. — (Fresh preparation, with addition of very dilute acetic acid.) a, single cells with endogenous division of nuclei; 6, a cancroid rod with concentric irlobules and outer cylindrical epithelium ; c, an epithelial pearl that has been crushed. Magnified 400 diameters. dies where lymph circulates, for there the tissue offers least resistance. IToster thinks he has proved that all these tubes and cylinders lie solely in the lymphatic vessels. Although all his evidence in favor cf this view is not tenable, it is still very enticing, for we might then readily understand why the adjacent lymphatic glands were occasion- ally infected early. 638 TUMORS. Subsequently, changes take place in these epithelial tubes ; groupr of cells unite and form globules, which gradually grow by the deposit of new cells of the form of flat epithelium, and thus form the cabbage- like, compound epidermis-globules (globules epidermiques, cancroid globules, epithelial pearls), which so much excited the astonishment of the first person that examined them. It is most probable that these globules are developed from a num- ber of conglomerated cells, increasing by division, and the peripheral layers of cells being flattened by pressure against the parts around, which are not very distensible ; hence the larger these pearls become the more they project from the cell-cylinders, and hence they often appear at the terminal points of the glandular acini. Among the cells in the pearls, as in the epithelial parts of these tumors else- where, we often meet cells with many nuclei ; also large cell-bodies, which have enclosed daughter and grandchild-cells. In some of these carcinomata stachel and riff cells have been found in great numbers, as in the boundary layers between the mucous and horny layers of the epidermis. If the epithelial masses have grown deep into the tissue, and if we make a section in these deeper layers of a hardened tumor of this variety, we find about the following picture, in which the alveoli, filled with epithelium, may readily be distinguished from the connective tissue which has become faveolate : Fig. 155. Prom an epithelial cancer of the hand, the blood-vessels incompletely injected. diameters. Magnified CARCINOHATA. 689 The vessels in this connective-tissue stroma assume about the shape in Fig. 156, a, while Fig. 156, #, shows a proliferation of vessels Fig. 156. Vessels from a carcinoma of the penis. Magnified 60 diameters. «, from the developed tu- mor tissue, vascular net-work around the epidermis pearls ; S, vascular loops from the sur- face of the indurated but not yet ulcerated glans penis. in the enlarged papillae of a glans penis, as it occurred just at the development of the first epithelial proliferations. While in the last-mentioned case, as often happens, the papillary hypertrophy appeared at the very commencement of the development of the tumor as an essentially characteristic part, in other cases it is of an entirely secondary nature, i. e., the epithelial rods on the sur- face of the skin or mucous membrane soften, fall out, and leave the vascular connective-tissue portion in the form of a pouched ulcer, from which different papillary tufts protrude or subsequently grow. Carcinoma of the skin may begin as indurated papilloma, or as a wart, but just as often it begins as a nodule when the proliferation is at first circumscribed, grows into the skin ; it enlarges slowly, without grow- ing by apposition of new, small carcinoma nodules. The carcinoma- tous proliferation may also enter and grow through the cutis from a gradually-increasing surface, without causing any great promi- nence. There is a decided difference between cancers of the skin, accord- ing as the epithelial proliferation enters the cutis more or less deeply ; some cases remain quite superficial, scarcely entering the subcuta- neous cellular tissue, and growing very slowly (flat epithelial cancer, Thiersch) ; others grow rapidly and enter the tissue deeply, destroy- ing it (infiltrated epithelial cancer, Thiersch). The above description 44 690 TUMORS. of cancer of the skin is from the infiltrated form ; in flat epithelial cancer the outgrowing cell-cylinders rarely grow deeper than the deep layers of the cutis, and consist chiefly of the small, round cells of the rete. Along with these proliferations the sebaceous glands become larger, fill up with developed large-celled epithelium, and the connective tissue is richly infiltrated with small-celled elements. In these new formations the development of epidermis pearls is rela- tively rare. As viewed on the patient in this commencing stage, the whole forms a hard, slightly-elevated infiltration of the cutis, covered with desquamating epidermis. This epithelial proliferation is not, however, very solid ; occasionally there are disintegration, softening, and detachment of the glandular proliferations and sebaceous glands. The highly-vascular connective tissue remains, and may continue to grow as granulations, or it may partially cicatrize. While this goes on in the centre of the new formation, the latter continues to grow, it may be very slowly, in the periphery. At their very commencement, the cut surfaces of epithelial cancer are pale red and hard ; in a short time they appear white and granu- lar ; occasionally we may see the large epithelial pearls and rods with the naked eye. Ulceration takes place from without .inward, even more frequently than by medullary softening from within outward, and usually quickly follows their development. Mucous softening is rare in these forms. In regard to the topography, we may mention the following regions of the body as the most frequent seats : (a.) Head and neck y here these tumors develop chiefly on the eyelids, conjunctiva, skin of the nose and face, the lower lip, oral mucous membrane, gums, cheeks, tongue, larynx, oesophagus, ear, and scalp. The first appearance va- ries greatly : the worst cases begin as nodules in the substance of the mucous membrane or skin, and quickly ulcerate from central soften- ing ; other cases begin on the surface ; a fissure, crack, indurated ex- coriation, epidermoid scab, or a soft wart, forms ; this at first apparently insignificant affection may remain superficial for a long time, slowly extending laterally, less so in depth, and having indurated borders. If the carcinoma develop from a wart-like formation, it may perma- nently preserve the papillary character. The parts once diseased are forever destroyed by the metamorphosis into cancerous tissue; in typical epithelial carcinomata there is no cicatricial shrinking; the ulcers which rapidly develop from these new formations vary, like other cancerous ulcers ; sometimes smaller or larger shreds of tissue from the depths of the ulcer become gangrenous, leaving a crater-like loss of substance ; sometimes the new formation proliferates, forming an ulcer with fungous, overgrowing edges. Not unfrequently, a CARCINOMATA. C91 cheesy pulp may be squeezed from this ulcerated surface ; it comes out in a worm-like shape, just as the inspissated sebaceous matter does from the glands of the skin (comedones or maggot) ; this pulp is a mixture of softened epithelial masses and fat. Sooner or later, there is a gradually-increasing swelling of the neighboring lymphatic glands of the neck, which is not unfrequently painful ; by degrees the glandular tumors unite together, or with the primary tumor ; new points break out, and the local destruction gradually progresses ; the new formation also extends in depth, destroying the bones of the face or skull, and taking their place. Death may result from suffocation or hunger, due to pressure of the tumor on the air-passages or oesopha- gus, or from pressure on the brain after perforation of the skull; more frequently, after gradually-increasing marasmus, it results from complete exhaustion, with the signs of excessive cachexia. On au- topsy,- we hardly ever find metastatic tumors in internal organs. All of these carcinomata on the head, face, and neck, are much more frequent in men than in women. The average duration of life of patients with cancer of the tongue and oral mucous membrane is a year to a year and a half. Cancers of the lips are radically curable by early and complete extirpation. In previous works, I have termed the above form of flat carcinoma of the skin, " cicatrizing, atrophying, epithelial cancer, or scirrhous cutis," to define it more accurately from ordinary epithelial cancer. But now it seems to me better to make no special subdivision of it, hence I at once state that this is the mildest form of cancer of the skin, and, with few exceptions, attacks old persons ; the disease occasion- ally begins as an infiltration of the papillary layer, with small nodules, always superficial ; usually there is at first a local collection of yellow- ish epidermis, a small scab, after whose removal the skin appears at first only slightly reddened, scarcely infiltrated ; when detached, the crust forms again ; after repeated detachments, we find under it a small, rough, fine papillary, dry, ulcerated surface, which occasionally has, even at this period, hard, slightly-elevated edges ; the small ulcer, on which new, dry crusts constantly form, extends through the cutis, but rarely into the subcutaneous tissue ; its tendency is rather to spread laterally, occasionally it even heals in the centre, forming a cicatrix and new healtlry epidermis, while a moderate induration and ulceration slowly progress in the periphery. In some cases there is no ulcera- tion, only infiltration of the skin, with epidermis-scales and subse- quent cicatricial shrinking. The most frequent seat of fiat epithelial cancer is the face, es- pecially the cheeks, brow, nose, and eyelids ; still other parts of the skin, which are subject to any form of epithelial carcinoma, may be 692 TUMORS. attacked by this form ; it is most frequent between the fiftieth and sixtieth year, and I find it as often in women as in men. Often the whole cutaneous surface, and especially that of the face and hands, appears very dry, and is covered by numerous dry, flat, yellow epider- mis-crusts, as well as by numbers of small infiltrations, which often disappear again. This cancerous infiltration extends very slowly; occasionally it is six or eight years before a portion of skin as large as a dollar, or a side of the nose, or an eyelid, or portion of the ear, is destroyed ; it rarely proceeds more rapidly. As the patients are gen- erally old, they occasionally die of other diseases, and, for the same reason, there is often no recurrence after operation. But, even in cases not operated on or treated in any way, this form of carcinoma appears infectious in but few cases ; the infection never extends beyond in- filtration of the lymphatic glands, which does not occur till late, and then goes on just as slowly as the primary infection. Some writers have wished to banish this form of cutaneous cancer from the lists of carcinomata, and to place it among chronic inflammations as ulcus rodens (Hutchinson) , or as a form of lupus peculiar to old persons. The various combinations of this neoplasia with distinctly-marked cancer in some points of the infiltrated edges, the possibility of its changing to proliferating cancer of the skin, and some other anatomi- cal and clinical peculiarities, render it certain, in my opinion, that this form of infiltration and ulceration belongs among the cancers, and is the mildest and most feebly infectious among them. (b.) The second part of the body where this form of carcinoma is frequent is about the genitals. The portio vaginalis uteri, vagina, labia minora, and the clitoris, the penis, especially the glans and pre- puce, are the parts most frequently affected. Of all these parts, the portio vaginalis uteri is especially liable to the disease, and here car- cinoma ulcerates rapidly, and, as the surface of the tumor becomes deeply fissured and assumes the appearance of a cauliflower, this is often called cauliflower cancer, but, as sarcomatous papillomata may produce the same forms, this designation is uncertain. On all of the above localities the ulcerated tumor may have a destructive ul- cerating or a fungous character, it may also be either infiltrated or superficial. The separation of uterine cancer is accompanied by very badly-smelling sanies, and often with repeated parenchymatous haemorrhages. As regards the subsequent course of the disease, the retroperitoneal lymphatic glands are affected sooner or later ; death usually results from marasmus; in these cases, also, we very rarely find metastasis in the internal organs, except in the neighboring glands which are directly infected. (c.) Of other parts of the body that require the attention of the CARCINOMATA. 693 Burgeon, we have to mention the hand, and especially the back of the hand. Not long since, I saw an epithelial carcinoma on the right forearm, which had developed from a fontanel, kept up for ten years with peas. I also saw an ulcer of the foot, wmich, after lasting for years, without any known cause became cancerous. (d.) We also mention here the carcinomata growing from the vesical mucous membrane, which also has a pavement epithelium. Inaccessible as it is for surgical treatment, the surgeon must still be well acquainted with it, to enable him to make a differential diagnosis. It has already been frequently mentioned that papillary proliferations occur in carcinoma ; this is particularly often the case in cancers on the inner surface of the bladder, which frequently grow in the shape of branched villi, and have consequently received the special name of " villous cancer." Cancers starting from the cutaneous epithelium and glands have the same relation to villous cancer that adenoma has to papilloma. When papilloma assumes a peculiarly luxuriant growth, and at the same time epithelial masses grow into the part of skin affected, soft- ening the connective tissue or muscle, in short, when the tumor as- sumes a distinctly destructive character, it may be regarded as car- cinomatous papilloma or villous cancer. The boundaries between Fig. 157. Papillary formation of a villous cancer of the bladder, after Lamhl. a, without, 6, with epi thelium ; c, isolated epithelial cells of the villi. Magnified 3r>0 diameters. 694 TUMORS. simple papilloma and villous cancer may be just as difficult to define as those between adenoma and carcinoma. As above stated, a tumor like a mushroom forms on the inner sur- face of the bladder, growing into its cavity, and floating in the urine. its base being attached to the wall of the bladder, like a carcinoma, and its long, branched villi being covered with very large epithelial cells, while the ground-work of the papillae is composed of connective tissue, whose meshes contain epithelial cell-cylinders, such as occur in carcinoma (Fig. 157). Now, a few words about the course of the above carcinomata as a class. They" usually appear in elderly persons, say from the fortieth to sixtieth year, rarely later, but, unfortunately, it is not so rare for them to come earlier ; I have seen cancer of the tongue in a boy of eighteen, and cancer of the uterus in a woman of twenty years. On the whole, country people are more subject to cancer of the lip than city people are. The earlier these carcinomata appear, the more pro- liferant the local tumor, the earlier the lymphatic glands are implicated, and the more rapid the whole course. It has often been observed that, after entire removal of the tumor, there is no recurrence. In some cases the disease runs its course very quickly, in a year ; in oth- ers it lasts three, five, ten years, or longer (flat cancer of the skin) ; sometimes, also, the recurrence is only in the lymphatic glands, as when a cancer of the lip has been completely extirpated, but at the time of operation cancer-germs were already present in the cervical lymphatic glands. The new formation in the gland at first appears pale red, is a rather hard, diffuse infiltration, or a white kernel, but with time it becomes softer, and, to some extent, pulpy and purulent. The cervical lymphatic glands infiltrated with cancer have a great tendency to ulcerate ; their microscopical structure is the same as that of primary cancer. I think there is no doubt that secondary cancer in the lymphatic glands is always due to transplantation of cancer- germs from the original focus (see page 607). The above forms of cancer scarcely ever go beyond the lymphatic glands ; infection of in- ternal organs (liver, lungs, spleen, kidneys) is very rare. The con- stancy with which carcinoma occurs at certain points, especially where mucous membrane passes into skin (vagina, penis, lips), has justly always excited much attention. It was natural to seek the causes of the disease in the structure of these parts, and in the irritations to which these openings were subjected ; the dislike that most modern pathologists have to specific, unknown irritations has induced them to seek different causes for explaining the obscurity about the specific CARCINOMATA. 695 causes of tumors of these parts. In regard to the lips in old persons, Thiersch attaches great importance to the fact that there, as in the cutis elsewhere, considerable changes take place with advancing age : there is decided atrophy of the connective and muscular tissues, so that the epidermis-formations, hair-follicles, sebaceous and perspira- tory glands, as well as those of the lip, attain the preponderance, and receive most of the nourishment ; hence all irritations affecting the lips (bad shaving, smoking tobacco, wind, bad weather, etc.) chiefly attack the glandular parts of the lip, and induce hyperplasia. In England, epithelial cancer often attacks the scrotum of chimney- sweeps (chimney-sweeper's cancer), from the irritation of the soot, it is supposed. These things may certainly have some effect, but it re- mains unexplained why they should be followed by cancers or infec- tious tumors, and not by chronic inflammations, catarrhs, etc. I shall not here follow this discussion further, but merely refer you to what was said about the etiology in the introduction to the section on tumors. 2. Mammary glands, I place cancer of the mamma here, as this gland is also a derivative of the epidermis, a cutaneous fat-gland on a large scale. The mammary cancers, however, differ greatly from those already described, and, although true epidermis-cancers occur in the breast, starting particularly from the areola, they are very rare. Mammary cancer, which is unfortunately very frequent, seems to me almost always to begin with a coincident enlargement of the small, round, epithelial cells in the acini, and with small-celled infiltration of the connective tissue around them. With our present methods of examination it is impossible to tell whether the first changes occur in the gland-cells, or in the connective tissue ; for the grouping of small, round cells about the acini soon becomes so excessive, that it constantly becomes more difficult to make out the further fate of the glandular acini. From my tolerably numerous observations on this subject, made by aid of the most improved methods, I think I may de- scribe the following as the subsequent course : The collection of cells in the acini leads first to their enlargement, which is occasionally accompanied by a trace of secretion (as is shown by the escape of serum from the nipple). As the collection of cells continues, there is more enlargement of the acini, and in such different ways, that we may distinguish an acinous (often large-celled) and a tubular (chiefly small-celled) form of mammary cancer. The former leads to the development of large, lobulated, glandular nodules ; hence I call this the " acinous form," since in it the rough outlines of the acini are preserved. The following picture is a slightly-magnified one of the borders of such a tumor : 696 TUMORS. Fig. 158. Mammary cancer, acinous form. Magnified 50 diameters. The groups of epithelial cells, which are enlarged and grown to thick glandular clubs, are enclosed by infiltrated connective tissue, and traversed by a fine net-work of connective tissue (stroma), which I regard as the remains of the former partitions between the acini, but which others consider as mostly new formation. Fig. m. Soft mammary cancer; alveolar tissue of the carcinoma; alcoholic preparation. Magnified 100 diameters. CAECINOMATA. 697 If we make a section through a hardened preparation of an aci- nous, soft, mammary cancer, when magnified more strongly, the tissue appears as above. I consider the cells in the large connective-tissue meshes as of epithelial origin (Fig. 159). This variety of mammary cancer is mostly soft, granular on section, grayish white (medullary). If we scrape the cut surface of such a cancerous tumor, we readily evacuate a thick, whitish pulp; if we ex- amine this while fresh, we find nodular cells, very pale, composed of large, many-formed cells with large nuclei ; many of these cells contain several nuclei ; they may perhaps be segregating. The connective-tissue frame-work in which these elements were embedded, when empty, looks about as follows, if strongly mag- nified : The second form, which is more frequent (is harder, and on section pale red), may be termed the " tubular " form, as the acini do not maintain their form, but grow into the connective tissue as very thin cell-cylinders, while it becomes infiltrated with cells. As in this form of cancer the cells from the epithelium do not usually grow so large as in the preceding form, and as the cells collected in the connective Fio. 160. Prom a mammary cancer. Magnified 300 diameters, a, cells with several nuclei (fresh prepa- ration, with some water added); &, glandular cell- cylinders (fresh preparation). tissue occasionally lie tegether in groups, it is evident that it must be very difficult to decide which of these cancers come from the cell- masses of glandular epithelium, and which are pure derivatives of connective tissue, former wandering cells. 698 Connective-tissue frame-work of a cancer of the breast ; the thick striae are plentifully infil- trated with young cells. Brushed-out alcohol preparation. Magnified 100 diameters. Hence all observers are not yet convinced that these frequent forms of mammary carcinomata are true cancer, as some of them Fig. 162. Cancer of the breast ; tubular form. Magnified 150 diameters. CARCINOMATA. 699 regard all the cells occurring here as derived from connective tissue. The final decision in this matter can only be made by the history of development; as long as we have no means of always distinguishing the young derivatives of epithelial cells from wandering white blood- cells, and the derivatives of connective tissue, we shall scarcely be able to say from every preparation whether this form of cancer of the mamma is more of an epithelial or connective-tissue nature. Although all forms of cancer of the breast have a tendency to ulcerate, this is more the case in the softer than in the harder forms. The hardness of cancer of the mamma does not always depend on its richness in cells, but even acinous cancers that are rich in cells may be hard, if the cells are enclosed in tense connective-tissue capsules, as the normal acini are. The softening is central in nodules lying near the skin, or in the harder forms it is more frequently from with- out inward at points where the tumor presses against the skin and has become united to it. Mucous softening occurs rarely, mucous metamorphosis of the gland-cells is probably never seen. To the naked eye the softened spots appear whitish-yellow, granular (cas- eous, fatty softening) or grayish or dark red from vascularity, espe- cially if there have been extravasations. By softening and encap- sulation of the softened spot, which may be deeply seated, cysts may be formed in these carcinomata ; retention and secretion cysts may also be developed in the mamma along with or in the cancerous tumor. Fig. 163. lb Cancer of the mamma, from a cicatricially-atrophied part. Magnified 200 diameters. Atrophy is a very frequent process in cancer of the mamma ; the nipple or other parts are thus retracted like the navel. On micro- Bcopic examination of these atrophied parts we see connective-tissue striae with atrophied connective-tissue corpuscles, and the section of fine, branched canals (atrophied alveoli) which are filled with cell 700 TUMORS. detritus or fat. This atrophy of the new formation is in some cancers of the mamma such an important factor, that it has given rise to a special form of cancer, " atrophying, cicatrizing cancer." It cannot be denied that in its pure form this variety of cancer has certain pecu- liarities which distinguish it from the ordinary, most frequent forms of cancer of the mamma ; hence w T e prefer to describe it separately hereafter. The development of cancer of the mamma is accompanied by con- siderable distention of vessels and new formation. In the youngest parts of the new formation there are numerous fine vessels and net- works of vessels ; in the older, especially in the softening parts, the vessels grow wider, then are thrombosed and destroyed, so that, about points of softening in tumors, similar net-works of dilated vessels form as are developed on the formation of abscesses. The following are the clinical symptoms of the development and course of ordinary cancer of the mamma. The disease usually begins between the thirtieth and sixtieth year, rarely earlier or later; the Fib. 164. Vascular net-work from a very young cancerous nodule of the mamma. Magnified 50 diameters. women attacked are usually otherwise perfectly healthy ; married and unmarried women, fruitful and barren wives, of all conditions, are at- tacked. Not unfrequently the parents or grand-parents have died of carcinoma. Most frequently in one breast, especially in the outer and lower part, there forms a tumor, at first small and painless, that some- times remains unnoticed for months ; it is hard, firmly seated in the CARCINOMATA. Y 01 Fig. 165. Vascular net-work around points of softening in a cancer of the breast. Magnified 50 diameters gland, but at first movable under the skin and over the pectoral mus- cles ; at first its growth is moderately rapid ; possibly a year passes before the tumor reaches the size of a small apple ; its volume is not always the same, occasionally it is larger and more sensitive, especially before and during the menses ; but occasionally the tumor collapses somewhat, and is perfectly indolent. These symptoms are partly dependent on congestion of the mammary gland, partly on atrophy and cicatrization going on in the tumor itself. With time, in the course of some months, the tumor grow T s larger ; the skin over it be- comes immovable, and below it adheres to the pectoral muscle. The patients frequently do not notice the commencement of the swelling of the axillary glands, and, if the surgeon's attention be not occasion- ally directed to this region, the enlargement of these glands, which appears as a hard swelling of these parts, is not discovered till late ; sometimes also these glands lie so deep and so high under the pectoral muscle that they are not felt till they have grown quite large. The lymphatic glands of the neck are less frequently affected in cancer of the breast ; w T hen they are, the prognosis is more unfavorable. If the progress of the tumor goes on undisturbed, the course, when moder- ately rapid, is as follows : The tumor of the mammary gland and those of the axillary glands gradually unite, so as to form a nodular, wavy, immovable swelling, which at some points adheres to the skin ; the pressure of the tumor on the nerves and vessels in the axilla causes neuralgic pains and oedema in the arm ; the patients, who pre- viously had felt perfectly well, are compelled to keep in bed by the pain and swelling of the arm, which come on more especially at night, and have a piercing, boring character, while previously they may have 702 TUMORS, been able to attend to their household duties. In this stage (say two years after the commencement of the first tumor) another symptom has usually appeared, or does so shortly, namely, "ulceration. This generally begins with the following symptoms : Part of the tumor be- comes prominent, the skin grows thinner and redder, is traversed by visible vessels ; finally a fissure or vesicle forms on the elevated, red, fluctuating tumor ; now part of the cancerous tissue which is exposed to the air becomes gangrenous, breaks into shreds, and a crater-like, excavated ulcer is left, which long maintains this shape, if the sur- roundings and base of the ulcer be still hard ; but, if the parts about the ulcer be already soft, the substance of the tumor begins to prolif- erate at the edges and from the depths, and to cover the parts around like a fungus. An ulcer, sometimes torpid, sometimes fungous, is thus developed ; its secretion is always sero-sanious ; badly-smelling, gangrenous shreds are often thrown off. But, what is still worse, parenchymatous or even arterial haemorrhages occasionally occur from the surface of the ulcer, and exhaust the patient. We have followed the condition of the patient till he has become partly or entirely bed- ridden ; we now soon come to the catastrophe : the patient becomes pale and greatly emaciated ; the appetite is lost, the strength grows less, the nights are often sleepless from the pain ; opiates must be resorted to, to give the patients sleep and temporary relief. We now have the well-marked picture of cancerous dyscrasia or cachexia. It may go on in this way for months ; the smell from the cancerous ulcer infests the chamber, the patients become weaker, the skin grows grayish-yellow and clayey. Pains on breathing and in the region of the liver, as well as in the bones of the limbs, come on. The patient becomes marasmic, and dies in agony after protracted, painful suffer- ing, unless the end is hastened by pleurisy or peritonitis. On au- topsy, in most cases we find carcinomatous tumors of the pleura, liver, and occasionally of the bones, it may be of the femur or of the vertebras, or else of the ribs on the side where the tumor of the breast was. The whole disease has lasted two years and a half. For many cases of cancer of the breast the above description will be very accurate, but there are some modifications of this course. First, the rapidity of the local course varies ; the tumor may remain confined to the breast, without any affection of the lymphatic glands — a very rare case. The disease of the glands appears almost simul- taneously with the tumor of the breast ; this always leads us to ex- pect a very rapid course of the disease, while conversely a very late and moderate local spread to the lymphatic glands indicates a mild, slow course of the whole disease. Carcinomata may come in the two breasts simultaneously, or in one soon after the other ; this makes the CARCINOMATA. 703 prognosis much worse. In some cases there is no isolated tumor of the breast, but the whole gland, with the skin, becomes diseased at the same time. Lastly, an adenoma or an adeno-sarcoma may have ex- isted eight or ten years, and then rapidly assume the character of a cancer, i. e., become immovable, painful, and accompanied by harden- ing of the lymphatic glands. Cases also occur where the tumor of the mamma diminishes so much that it is supposed it has entirely dis- appeared ; unfortunately, this does not prevent the general outbreak of the disease, although it appears to retard it, or only to occur in mild cases, such as run on from four to six years. Some patients die early of anaemia from the ulceration and haemorrhage, without any metastatic tumors having formed. The period for the occurrence of metastatic cancerous tumors in the internal organs also varies ; gener- ally, when the local growth of the tumor is slow, metastatic tumors appear late ; still, there are exceptions to this rule. In cancer of the breast the localization of the secondary tumors is very regular, as already stated • the pleura, liver, and bones, are the most frequent seats of metastatic tumors. The varying course of cancer of the breast renders it ver} r diffi- cult, indeed almost impossible, to compare the result of early or late operations with those cases that run their course without operation ; even the age of the patient causes great differences : in old persons, the disease almost always runs a slower course than in young ones ; numerous entirely unknown influences come in play. The most ex- perienced surgeons have given very different opinions about operating, some declaring that the course of the disease is hastened by operation, others that it is retarded. The statistical tables that have been pub- lished aid little in solving this question, because cases of all sorts are thrown together in them ; to obtain a correct result from them, the cases must first be separated on certain principles. But what good would this do ? It would always be a question, in each case, whether we should aid the patient by an operation or not. The tumors will almost always return in the cicatrix, in its vicinity or in the neighbor- ing lymphatic glands, because they are usually operated on too late ; the patients will then die of metastatic tumors, if they are not carried off sooner by suppuration, haemorrhage, or acute disease. How much does the patient suffer from the tumor? What danger does it induce locally ? These are the first urgent questions. But I am anticipating by considering here the treatment, which we propose studying more attentively at the end of this section on cancerous diseases. Exami- nation of the enlarged lymphatic glands, which partly adhere together, shows that the smaller are more succulent and vascular than normal : 704 TUMORS. the larger contain hard white or grayish-white nodules, and are occa- sionally softened, caseous, and have a granular cut surface. On the whole, the lymphatic glands show the same characters as primary can- cers ; this also extends to the microscopic texture. Although it could probably only be proved in pigmented carcinoma that the first swell- ing of the lymphatic glands depends on transformation of tumor-cells into the lymphatic glands, still I consider the same thing true of all carcinomata; in some cases the. epithelial nature of the new forma- tion in the lymphatic glands is just as striking as in the primary tumor of the breast, in others such a distinction is impossible. Carcinomatous nodules of the pleura, which develop after car- cinoma of the breast from direct conduction of the seeds, are usually hard, pure white, and small-celled; the same is true of the external appearances of secondary cancer of the lungs and liver ; but the latter are not unfrequently large-celled and acinous. Although I regard it as probable that these carcinomata are also due to direct emigration of carcinoma-cells or to transportation of the latter by the lymphatic or blood vessels, this cannot be proved. Some cases deviate from the above course, as is shown by early and continued shrinking of the new formation. This form is called scirrhus mammce, atrophying, cicatrizing, shrinking carcinoma, con- nective-tissue cancer. The picture of the disease and the anatomical changes will appear from what follows. In the mammary gland, rarely before the fiftieth year, there forms a hard spot — we cannot say a swelling — but the hardening is rather accompanied by a partial or even a total decrease in size of the gland; this hardening usually forms without, rarely with severe pain ; it comes on very slowly. If we now suppose the hardened glands removed and examine the diseased portion, we find the tissue so hard that we can scarcely cut it ; to the naked eye, the cut surface shows a hard, fibrous cicatrix, with connective-tissue striae gradually extending into the comparatively healthy parts around. In typical cases, except this cicatrix, we shall scarcely discover any thing pathological with the naked eye ; but, at the periphery of some of these tumors we see a pale-reddish part with a fatty lustre, more marked in spots, lying be- tween the cicatrix and the healthy tissue, and passing into both. If we examine fine sections of the cicatricial tissue after previously hardening it still more in alcohol, we find little besides connective tissue and elastic filaments ; but the connective-tissue strias have not the same peculiar regular course that they have in fibroma ; they are irregularly intertwined, and, as above stated, they are accompanied CARCINOMATA. 705 by many elastic filaments, which rarely happens in fibroma. But examination of the bordering tissue gives the following : There is cell-infiltration, to a very slight extent, it is true ; there is development of small groups of pale bodies, like lymph-cells, with single nuclei, as in the commencement of any new formation. Part of these cells are arranged in long groups (tubular), somewhat larger than the rest; these are doubtless derivatives from the epithelial remains of the shrunken glandular acini. All the cells of the neoplasm appear to be very short-lived, for they are scarcely formed before they commence to decay, without going on to further development ; then the con- nective tissue, which has been somewhat distended, shrinks together, and, as a result of this process, we have the cicatrix; but peripherally this slight cell-infiltration constantly extends ; hence complete, spon- taneous disappearance of the new formation very rarely, if ever, occurs. If the borders of this tumor be inspected under a low power of the microscope, we see how the small-celled infiltration advances between the meshes of the connective tissue, and closely follows them. Fia. 166. Connective-tissue infiltration advancing into the cntis from the borders of a cancerous nodule of the mamma; the dark shadings correspond to the advancing small-celled infiltration. Magnified 50 diameters. The extension of this infiltration into the fatty tissue occurs just as in inflammation ; most of the 3 r oung cells are found in the vicinity of the vessels, so that we can scarcely avoid thinking that in these cases also white blood-cells escaping from the vessels cause the cellu- lar infiltration. As in these cases the infiltration of the connective tissue with 45 706 TUMORS. lymphoid cells is very decidedly the predominant morbid process, while the epithelial proliferation is very secondary, I formerly tried to give this form of cancer of the breast the name of " connective-tissue cancer." But, as this has led to misinterpretation in regard to the modern anatomical understanding of carcinoma, I shall not try to preserve this term. Fig. 167. Cellular infiltration of the fatty tissue in the periphery of a hard cancer of the breast ; the blood- vessels injected. Magnified 200 diameters. The peculiar anatomical and clinical course has caused some sur- geons to strike this new formation from the list of tumors, and par- ticularly from that of cancers. If we examine more closely the clinical course of these cases, we have already noticed that they usually only occur in old persons, and that the local disease progresses slowly ; some cases last seven or eight years before half of one breast is atro- phied. The general health meantime remains unimpaired. The lymphatic glands occasionally participate in the disease ; in this case the process goes on just as in the mamma ; there is very little enlarge- ment, but much hardening and cicatricial shrinking. The more rap- idly and completely the new formation atrophies, and the more slowly the process extends, the more injurious it is ; after extirpation or cauterization this variety of cancer does not recur for a long time, if it does so at all; metastatic tumors are rare; in the main, the infiltra- tion does not appear to differ much, anatomically, from that in chronic hepatitis and nephritis with subsequent shrinking ; why, then, distin- guish this scirrhus from those processes ? Wernher terms this disease of the mamma cirrhosis mammae. I recognize perfectly the justice of doubting the carcinomatous nature of some cases of scirrhous mam- CARCINOMATA. 707 mas, but must still insist upon classing them generally among cancers, for the following reasons : As you already know, among tumors the process of contracting is peculiar to cancers ; moreover, the contract- ing cancer is not unfrequently combined with ordinary cancer; indeed, it is more common for more or less cancerous proliferation to go on along with the scirrhous affection, while the wholly-cicatrizing cancers are relatively rare. This combination, which occurs neither in cirrho- sis of the liver nor of the kidney, speaks entirely for the near relation of this cicatrizing new formation to cancer ; in these combined cases there are also local recurrences of the extirpated tumors, tumors of the lymphatic glands, and even metastatic cancers of internal organs. In the tumors that consist chiefly of cicatricial substance, and hence are to be classed rather with scirrhus than with ordinary cancer, we may give a tolerable prognosis, inasmuch as the disease always runs a slow course. We now mention another form of cancer of the breast which also begins as an induration in the gland, but soon extends to the skin, and there, in the form of small nodules, quickly spreads over the whole skin of the anterior wall of the thorax ; the second breast is often affected the same way. This cancer lenticitlaris (Schuh), squirrhe pustuleux ou dissemine ( Velpeau), apjDears partly as a primary, partly as a recurring form after extirpation of hard cancer of the breast, and not exactly in old women. This small nodular (we might almost say tuberculated) form may, by confluence and contraction, lead to actual lacing in of the skin of the thorax from the front and sides (cancer en cuirasse, Velpeau) ; the course is slow, the tendency to metastases to internal organs is not great, but the prognosis is very bad, because every attempt to prevent local extension by operation is in vain. 3. Mucous membranes with cylindrical epithelium. Most cancers that form in the nose and antrum Highmori, and gradually extend to the upper jaw, ethmoid and sphenoid bone, as well as into the orbit, start from the mucous membranes of the nose and antrum Highmori. The ciliated or non-ciliated epithelium of these membranes only ex- tends to the openings of the mucous glands, and even in the develop- ment of cancers of the glands at these points rarely grows into the deeper parts. It appears to be rather the acini of the gland itself from which the proliferation proceeds, for these cancers appear to be mostly composed of acini or tubuli, which have small or larger round cells, rarely cylinder-cells, still more rarely ciliated cells. The shape of the newly-formed acini and their size here differ enormously, but often V08 TUMORS. are so distinct, so normal, that they may be mistaken for normal mu- cous glands ; to render this deception complete, it not unfrequently happens that the newly-formed acini secrete mucus, which remains and collects in them. If the secretion from many acini be retained, Fig. 168. Cancer of the mucous glands from the interior of the nose. Magnified 200 diameters. the form of the neoplastic glandular acini be perfectly round, and the interstitial connective tissue be but slightly developed, the hardened, fine sections of such a tumor may very much resemble tissue of the thyroid gland. The interstitial tissue is usually very soft in these tumors; as in the corresponding mucous membranes themselves, it may be almost mucous. Interstitial papillary proliferations of hyaline vascular connective tissue (cylindroma) also occasionally occur here. These tumors are always very soft, white, medullary, or gelatinous, except when very vascular ; then they are dark red. The bones are destroyed by caries, without a trace of reactive bony new formation or osteophytes. The appearance and clinical course of these tumors are somewhat peculiar, differing from other carcinomata. They occur any time after the twentieth year, grow rapidly, and project sometimes through the nares, again through the cheeks or inner can thus of the eye ; they are occasionally very sharply bounded or encapsulated, which may be known by palpation, and proved on operation ; some* CARCINOMATA. 709 times tliey are more diffusely spread in the upper jaw. In these mu- cous-gland cancers of the face I have never seen infection of the lym- phatic glands, and am convinced that these patients could be saved by an early complete operation. In all the patients that I .have operated on, I have never been satisfied that the tumor was entirely removed by the operation ; it always projected too far posteriorly or upward to per- mit the operation to be completed with safety. Hence, I usually wit' nessed local recurrences, which proved fatal by marasmus or pressure on the brain, or else the patient died from the extent of the operation ; in none of the cases examined post mortem did I find internal tumors. In the stomach gland-cancers are frequent, especially with mucous softening (gelatinous cancer), and secondary cancer of the liver ; can- cer of the duodenum is very rare ; of the parts of the intestinal canal attacked by this disease we are only interested in the cancers of the rectum. These are almost exclusively gland-cancers, and the prolifer- ation proceeds from the large glands of the large intestine, which grow in the shape of tortuous and branched tubes ; the calibre of the gland is often maintained, and they fill with mucus, and the cylinder- cells may maintain their form and become very large. The intersti- Fig. 169. Adenoid cancer of the rectum. Magnified 200 diameters. tial connective tissue is strewn with small, round cells, sometimes softened, and often very vascular. Usually at first the muscular coat of the intestine is hypertrophied ; subsequently it also is affected by ».he ulceration, which generally begins earlv. 110 TUMORS. As the first symptoms of cancer of the rectum are usually consti- pation, discharge of mucus, and slight haemorrhage, these patients are mostly treated for some time as if suffering from haemorrhoids, be- fore the diagnosis is made by digital examination. Induration and nodular infiltration, leaf-like proliferations commencing close above the sphincter ani, soon extend to the whole circumference of the mucous membrane, so that a thick, prominent ring, a stricture of variable length, may be felt. This new formation can only be removed by ex- tirpating the rectum. When the rectum is taken out, we generally find an ulcer with elevated edges and indurated base, and the parts around infiltrated with medullary substance; at some points also there are cicatricial contractions. The inguinal and retroperitoneal glands are affected rarely and late in the disease. The patients gen- erally die from the stricture of the intestine, from marasmus, due to haemorrhages, and putrefaction of the cancerous tissue. Occasionally also cancers, composed mostly of cylindrical epithe- lium, start from the pars cervicalis uteri. These first attack the uterus, then the surrounding parts, and lastly infect and infiltrate the retroperitoneal glands ; they combine with flat epithelial cancers, and do not differ from these in their course. 4. Lachrymal^ salivary, and prostatic glands. The same kind of tumors grow from the lachrymal glands that we have already de- scribed as growing from the nasal mucous membrane, acinous glan- dular new formations, with soft, occasionally mucous, or even papillary hyaline interstitial connective tissue (cylindroma). They develop about the age of puberty, and are characterized by great tendency to local recurrence. All the cases of this nature that I have known of finally died from the local recurrence; it might be not for sev- eral years ; neither the lymphatic glands nor internal organs were affected. 0. Becker has described tumors of this sort, in which most of the glandular acini contained a certain quantity of mucous secre- tion, as also occurs more especially in the glandular cancer of the rectum. The salivary glands may also be the seat of glandular cancer, but they do not come till old age ; then, however, they grow rapidly, and not unfrequentfy resemble chronic inflammation. The newly-formed acini are often more tubular than acinous ; epithelial pearls occur on the ends of the tubuli, covered with cylinder-cells. These patients usually succumb to the ulceration of the tumor and the general ma- rasmus ; internal carcinoma is a rare sequent. In the prostatic gland I have seen glandular cancer a few times ; it was very soft, and in one case where partly extirpated it was very vascular, and of acinous structure. From the excellent statistical CARCINOMATA. 711 work on malignant new formations in the prostate by 0. Wyss, it ap- pears that, in almost every case, these carcinomata also prove fatal solely from the local symptoms. Lymphatic glands and adjacent parts become infected ; there are very rarely secondary cancers of in- ternal organs. 5. Thyroid gland and ovary. I place these two organs together, as they both originate from true glandular epithelium, and both con- tain follicles, formed by choking off of glandular canaliculi. In can- cerous disease both organs fall back into the embryonal type, i. e., the follicles grow again to tubes and canaliculi, from which again new follicles are developed; but some of these carcinomata, which are rare, consist entirely of cell-canaliculi, without any development of follicles. Young persons, as well as old ones, may be attacked by this form of cancer. Its course is usually rapid, for the cancers of the thyroid grow into the windpipe or close it by pressure, while the ovarian tumors are characterized by their enormous growth and rapid adhesions with the surrounding parts, and by the speedy development of ascites prove dangerous. From variations in their course and anatomical structure we must separate the different forms of carcinoma ; we may consider their treatment together. Treatment of the carcinomatous dyscrasia (car- cinosis) is usually regarded as a partie honteuse of medicine. I can- not admit this. It is true we cannot cure the disease ; but is not this also true of many other acute and chronic diseases ? Can we arrest a cold in the head at any stage ? Can we check the course of the acute exanthema or typhus ? Can we cure tuberculosis ? Certainly not ; in all these cases, as in many others, the disease runs its typical course ; we give little medicine, at least we avoid all heroic reme- dies. In carcinosis our therapeutic impotence only appears so great because the disease almost always proves fatal, and we can do nothing to oppose its course; in fact, our treatment is as inefficacious in coryza as in carcinosis ; but the former is not a fatal disease, hence no special demand is made on the physician. We have become accus- tomed to failing to cure cold in the head ; we must grow accustomed to the course of cancerous as to that of some other diseases ; this will not interfere with our sympathy for these poor patients, nor must it prevent our striving for increased knowledge and improved treat- ment of the disease. I think that much may yet be attained in this direction. The indications for treatment are to remove the cancerous tumor as soon as possible, so as to avoid infection, or at least obstruct its course, and thus diminish the evils accompanying it. 712 TUMORS As long as cancer has been known, remedies for it have been sought ; there is no active medicine, no form of dietetics, or mineral springs, that have not been recommended for cancer, and, to some ex- tent, actually believed in. I should have to root up the entire old and new materia medica if I would tell you of every thing that has been thought and written on this subject. Like all incurable dis- eases, carcinosis also has been a wrestling-place for the charlatan, and even of late years Italians and Americans have claimed to cure the disease by special nostrums. Unfortunately, all these are deceptions, or at least what part of it is true has been long known. Unfortunately, the etiology of cancer gives no clew to treatment ; we know too little of the causes why certain tumors are so infectious, while others are not so. A blow, kick, etc., may occasionally induce an outbreak of the disease in some few cases, but cannot excite the predisposition to cancer. In some cases inheritance of the disease is evident. Care and anxiety may hasten the course of the disease, but do not induce it. All this is of no avail for the treatment. There is no specific for carcinosis ; but by this we do not mean to say that all internal treatment is unnecessary or useless. By no means. The disease should be treated internally whenever there are indications for treatment, or any symptoms pointing to the use of certain reme- dies. As anaemia is not unfrequent in cancerous patients, iron in va- rious preparations, or chalybeate mineral waters, may be employed. Occasionally, in persons with faulty nutrition, cod-liver oil, etc., as well as bitter medicines, prove beneficial by aiding digestion. Very debilitating treatment, by sweating, purging, mercurials, etc., is to be avoided, for life will be preserved the longer the more the strength is maintained. Among the mineral springs, the active ones, such as Aix-la-Chapelle, Wiesbaden, Karlsbad, Kreuznach, and Rheme, are injurious ; only the milder indifferent thermal springs, such as Ems, Gastein, Wildbad ; also, milk and whey cures, strengthening moun- tain air may be recommended without injury, if their use seems on other accounts desirable. Residence in southern climates is usually of little benefit for cancerous patients. Toward the end of life, when debility is increasing, a strengthening, easily-digested diet is impor- tant ; and lastly, as the pain increases, the skilful use of various nar- cotics relieves the sufferings and death of the patient. The disease of internal organs may offer special indications to which I shall not here refer. So much about internal treatment, which I only follow when not quite sure of the diagnosis, or when I do not consider the case suited for operation. As regards external treatment, the first thing alwaj^s is the re- moval of the tumor, if this is admissible, from its locality. The opera- CARCINOMATA. 713 tion may be done with the knife or caustics ; the ligature or 6craseur can scarcely ever be employed here (the latter, perhaps, answers only in amputating the penis or tongue). But, before passing to the choice of either of these methods, we must consider the question, whether it is advisable to operate at all, even if it can be done easily and without danger to life, for the views of experienced surgeons differ on this point. Some surgeons never operate for cancer. They assert that the operation is always in vain, because the disease recurs ; if the re- curring tumors be operated on, new recurrence takes place the sooner ; these surgeons even assert that, the more we operate locally, the sooner secondary lymphatic tumors and metastatic cancers form, the local tumor acting as a sort of derivative for the tumor-disease ; that this product of disease cannot be removed without favoring the out- break of the disease elsewhere ; that, if we nevertheless wish to re- move the tumor, we should lead the morbid juices to some other point, as by establishing an artificial ulcer by means of a fontanel or seton. Concerning this view, which comes from the old humoral pathology, we may say that it remains unproved, and is partly also disproved by experience. We consider it as demonstrable by daily experience that the glandular swellings are essentially due to the development of the primary tumors ; we have already stated our belief that the participa- tion of the lymphatic glands in carcinoma is, according to all analogy, caused by local contagion, let the process be what it may. When cases occur where, after removal of cancers of the breast or lip, swell- ings of the lymphatic glands appear, though previously imperceptible, we must consider that the commencement of the disease was so slight as to escape observation. — How far the existence of a primary and secondary cancer of the lymphatic glands influences the subsequent course of the disease, the appearance of metastatic tumors and general cachexia, is a question which cannot be answered, because the disease does not run its course in a regular time ; if it did, we might form a rule as to the advisability of operating, by comparing cases that were operated on with those that were not. Approximate results might be attained by classing together cases that were alike in age, consti- tution, variety of the tumor, etc. ; but, as the accurate distinction of the varieties of carcinomata, and consequently an exact arrangement of the cases, has only lately been attained, and even now is not gener- ally known, we cannot at present expect much in this direction ; in- dividual observations rarely suffice for definite conclusions. The ex- perience from carcinoma of the face, that the most extensive disease of the lymphatic glands is very rarely accompanied by metastatic tumors, strongly favors the belief that the disease is not made more active by these strongly-developed local tumors, and that carcinomata 114: TUMORS. of the lymphatic glands do not increase the predisposition to metasta- tic tumors. — In reply to the question, whether carcinoma should ever be operated on, we may say that operation probably has no direct in- fluence on the diathesis, and that the operation, if done at all, must be done for other reasons. We said intentionally that the operation has no direct influence on the course of the disease, but we think it has an indirect influence, as the tumor induces other causes of disease ; the weakness, anaemia, and disturbance of nutrition caused by the sup- puration and pain from a cancerous tumor, perhaps also the constantly gnawing care with the ever-recurring reflection on the incurable nature of their disease, are factors which may well hasten the course of the malady. Under some circumstances I consider it the duty of the physician to deceive the patient about the incurability of this disease, whether he considers an operation as possible or not; where the physician cannot aid the patient, he should alleviate his sufferings, mental as well as physical. Few persons have the quiet of mind, res- ignation, firmness, or whatever you choose to call it, to enjoy what remains of life, if they know they have an incurable disease. Although perhaps externally quiet, patients will thank you little for confirming what they may have feared. On this point you will have many trials, and I must leave you in each case to do whatever is dictated by your personal shrewdness, knowledge of men, and your feelings. — Although we may not get rid of the diathesis by the operation, as when, having removed a diseased portion of breast, we fail to prevent new nodules forming in the remaining portion which was previously healthy, or in the other healthy breast (regional recurrence), soon after the cicatrix has healed, still by the early removal of the primary tumor we may prevent the neighboring glands, or the adjacent portion of mamma, from becoming diseased. Few as are the complete recoveries from cancer of the breast after operation, I believe they will grow more frequent when the family-doctor, to whom they are generally first shown, urges operation earlier, for at present they usually let the best time for operation slip by, and the women do not consult professed surgeons, till the local disease and the affection of the axillary glands are so far advanced that a complete operation is no longer practicable. The favorable results from early extirpation of true cancer of the lip should embolden us to remove other cancerous tumors early. If it has hither- to rarely been possible to operate on cancers early and completely, there are still important local causes which indicate even late opera- tions, to prevent as long as possible the advance of the tumor to parts where the disease would necessarily destroy life. Although in most cases there will be local recurrence, this will not take place for months, perhaps for a year , meantime, life will not be directlv endangered ; CARCINOMATA. 715 occasionally also it is a question of saving from entire destruction cer- tain parts of the face, as the lips, eyelids, or nose, which may subse- quently be replaced by a plastic operation. It would be very unjust to consider such operations useless, because they cannot cure the dis- ease, for they render the patient's life easier and more agreable — if only for a time, still, possibly, for the greater part of the time that he yet has to live. We might be very glad, if, by an operation or other treatment, we could temporarily restore to the pleasures of life a patient with advanced tuberculosis of the lungs, as is the case in oper- ating for some cancerous tumors. In short, there are many cases where we do good by the operation ; very often I should consider it wrong to refuse to operate. — We see other cases, however, where it is more difficult to decide. In slowly-progressing cancers of the breast, as in connective-tissue cancers, I consider an operation, which is free from danger, as admissible, but not necessary. If an eyelid be de- stroyed, or the nose partly or entirely lost, an operation is advisable, in the first case to protect the eyeball, in the second to remove the deformity, and the rather so, because in these slowly-progressing flat cancers of the face frequently there is no local recurrence ; in such cases only one thing would prevent my operating, viz., great debility or advanced age of the patient ; at least then extensive plastic opera- tions are no longer advisable ; even the unavoidable loss of blood, and keeping the patient in bed after the operation, may suffice to extin- guish the feeble vital spark. Then comes the question about the ad- missibility of the operation, where the tumor is in a dangerous loca- tion, when an operation is necessary that may end fatally, or at least is just as likely to end fatally as to result in cure. Here we have to drop general reflections, and consider the individual cases ; the danger seen in an operation varies greatly with the experience of the surgeon, and the individuality of the patient ; one principle we should adhere to : only to operate when after careful examination we can hope to remove all of the diseased part ; a half-operation, leaving behind por- tions of the tumor, should never be done. We should be careful to operate only in healthy tissue, if possible a centimetre or more from the perceptible infiltration, for in this way alone can we be certain of removing all of the diseased part. Occasionally in desperate cases we may prolong life by a bold operation, even if the cancerous tumor be already very large, but generally in such operations we shall see more patients die than will recover. We have now to criticise the caustics chiefly used in cancers. In the course of time opinions about caustics have differed greatly ; at times they were greatly preferred to the knife, again they were en- tirely thrown aside. The views of most surgeons of the present day, 716 TUMORS. as well as my own, incline to the latter view. I decidedly prefer the operation with the knife or scissors, because I then know exactly what I remove and I can judge more certainly if all the diseased part has been excised. Hence, I regard the operative removal of cancer as well as of other tumors to be preferable as a rule. But where there is a rule there are exceptions. In very old, anaemic, or timid patients, caustics may be employed, and, if the treatment be continued till all the diseased portion is destroyed, the result will be favorable. Physio- logically caustics would have some advantages ; for it is supposable that the cauterizing fluid may enter the finest lymphatic vessels, and thus more certainly destroy the local disease. But this does not oc- cur readily, because the tissue with which the caustic comes in contact instantly combines with it, and its further flow is thus prevented. Formerly it was asserted that recurrence did not take place so soon after the use of caustic as after operation with the knife, but this has not been confirmed ; hence I only maintain the above ex- ceptions. For a caustic I prefer chloride of zinc to all others for destroying cancers ; you may use it as paste or as caustic arrows. If it is a sur- face you wish to cauterize, to equal parts of powdered chloride of zinc and flour you add enough water to make a paste, which you apply to the surface. If you desire to cauterize more deeply, you mix one part of chloride of zinc with three parts of flour or gum and some water, and let them form a cake and dry ; this may readily be cut up into small pointed cylinders half a centimetre or more in thickness ; with a lancet you make an opening in the tumor and press the caus- tic arrow into it ; you repeat this operation till the tumor is perforated with arrows at about three quarters of an inch distance from each other. In four or five hours this cauterization is followed by moderate, often by very severe pain, which you may greatly modify by giving a subcutaneous injection of morphine directly after the cauterization ; the next day you find the tumor changed to a white slough. This becomes detached after five or six days, earlier in soft tumors, later in hard ones. If the cauterization has extended far enough into the healthy parts, after the detachment of the eschar there is left a good granulating wound, which soon cicatrizes ; if the carcinomatous mass again grows, the paste or arrows should be again applied, etc. These cauterizations are occasionally very painful and uncertain as regards the extension of the caustic, but they occasionally are advantageous. Other celebrated caustics are Vienna paste, arsenic paste, butter of antimony, chloride of gold, etc. ; iodide of potash, chromic acid, concentrated solutions of chloride of zinc, fuming nitric acid, sulphuric acid, etc., are less employed. CARCINOMATA. 717 Now a few words of advice about the local treatment of cancer- ous ulcers which are not, or at least are no longer, suited for opera- tion. In some of these cases the proliferation of the cancerous mass from the wound is enormous, and it often annoys and debilitates the patient ; here we may make partial cauterizations or employ the hot iron ; by the palliative destruction of the proliferating mass, we occa- sionally attain tolerably good results. The chief indication for treat- ment in these patients is suppuration of the ulcer, which is occasionally horridly fetid, and sometimes the pain. For preventing the disagree- able secretion, the hot iron is a good remedy ; the smell may be les- sened by compresses wet with chlorine-water or purified acetic acid, creosote, carbolic acid, permanganate of potash, sprinkling with pow- dered charcoal. The latter readily absorbs gases, as you know from chemistry, and is here an excellent remedy ; unfortunately, it dirties the wound, so that we abstain from its frequent use. For the pain of carcinomatous ulcers, narcotics have been applied locally, as by sprink- ling on powdered opium ; but, when injected subcutaneously or given internally, the narcotics act more certainly ; hence at last we always resort to morphine for these poor patients. I particularly enjoin on you patience in caring for and alleviating the sufferings of these unfor- tunates ; it is indeed sad for the physician to be able to do so little good in these cases, but still you must not abandon them. JBBIEF EEMAEKS ABOUT THE CLINICAL DIAGNOSIS OF TUMOES. I cannot take it amiss if you are at first somewhat confused by what I have said to you about tumors ; if it will encourage you, I may acknowledge that formerly it was the same with me when I was in your present position. Only long study and practice in the differen- tial diagnosis of tumors, for which there is opportunity in the clinic, render it possible to attain any certainty on this difficult point. The consistence of the tumor and its appearance, its relation to the parts around, its locality, the rapidity of its growth, and the age of the pa- tient, are the points from which we start in judging ; sometimes one, sometimes another, of these points gives the decision. Let us take an example : A man about fifty years old comes to you, ruddy and strong for his age ; for many years he has had a tumor on the back, which formerly gave him no trouble ; it has only been inconvenient since it has reached nearly the size of a child's head. The tumor is elastic, soft but not tense or fluctuating, movable under the skin ; the latter is un- changed ; there has never been pain in the tumor, nor is any caused by the examination. In this case the diagnosis is very easy : from VI 8 TUMORS. the location, from its seat in the connective tissue, its slow, painless growth, etc., it can scarcely be any thing but a lipoma, or possibly a soft connective-tissue tumor ; but the former is most probable. Let us take another case : A woman with a tumor of the breast comes to you ; this tumor is hard, nodular, as large as an apple ; over the sur- face the skin is retracted at spots, and is adherent to the tumor. From time to time there has been piercing pain, the tumor is sensi- tive to pressure, the axillary glands on that side feel hard. The woman is forty-five years old, well nourished, and looks healthy. Here also the diagnosis is easy; it is a carcinoma: 1. Because the patient is at the age when cancerous tumors of the breast are most frequent, while adenoma and sarcoma usually occur earlier ; 2. The consistence might point to fibroma, but this very rarely occurs in the breast, and the swelling of the lymphatic glands speaks against this view, and in favor of carcinoma ; 3. Carcinomata are painful, as this case is, while sarcomata and fibromata are not so, usually. We might give further reasons for the diagnosis, but these will suffice. Let us take a third case : A boy ten years old has had for two years a slowly-enlarging, moderately painful swelling of the middle part of the lower jaw ; at this point the teeth have fallen out without being diseased ; the en- largement of the bone is evenly round, and reaches from the first back tooth of one side to the similar point on the other ; below, it is hard as bone, above (in the mouth) it is covered by mucous membrane, is firm and elastic. Can this bony swelling be the result of chronic in- flammation, of a caries or necrosis ? This is not probable : 1. Because the pain has always been slight ; 2. Because there has been no sup- puration, which would scarcely fail to occur in an inflammation of the jaw that had lasted two years; 3. Because the swelling is more bounded and regular than it is apt to be in bony deposits in caries and necrosis ; 4. Because, at the patient's age, osseous inflammation in the lower jaw is not apt to occur unless from phosphoreous poison- ing, which has not occurred here. Hence this is a case of tumor ; is it an osteoma ? The part projecting into the mouth is too soft for this ; we may pass a fine needle into the tumor from above. Is it a chondroma? Consistence, form, mode of growth, and age of the patient, agree with this view, but the locality does not ; chondromata in the middle of the lower jaw at this age are very rare. It is a cen- tral osteo-sarcoma, probably a giant-celled sarcoma ; all the symptoms speak in favor of this idea, and you know that these tumors are fre- quent in the lower jaw during youth. I say you know — I might better say you will gradually learn ; and I can only advise you, whenever you have examined a patient with a tumor at the clinic, to read about it when you go home, and to compare the individual case with the CLINICAL DIAGNOSIS OF TUMORS. 719 general characteristics of the tumors that I have given you. When you have done this for a time, and in the course on pathological histology, under the instruction of your teacher, have examined many tumors, you will obtain a better idea of them, and will have all their peculiarities painted on your memory. CHAPTER XXII. AMPUTATIONS, EXARTICULATIONS, AND RESEC- TIONS. LECTURE LI. Importance and Significance of these Operations. — Amputations and Exarticulations. — Indications. — Methods. — After-Treatraent.— Prognosis. — Conical Stumps. — Prothe- sis. — Historical Eemarks. — Resections of Joints. — History. — Indications. — Methods. — After-Treatment. — Prognosis. Gentlemest : We have often had occasion to speak of amputa- tions and resections ; so, before closing these lectures, I will explain to you these important operations, by which we remove limbs or portions of limbs which are so diseased that we cannot restore them to health. These operations, which are often so beneficial, even to saving life, are sometimes regarded as a testimonium paupertatis of surgery ; for cutting off diseased parts is not a genuine cure, if by cure we mean by our skill to restore to its normal state a part of the body which has been changed by disease. However, if you take this high standard for every thing in our art, the bounds of medical science will become very limited. In the same way, you could say a cataract is not curable ; for the cloudy lens is not again made clear, but is removed. Many of the most brilliant cures made by derma- tologists, where they have used caustics, must be regarded as proofs of the impotence of our art ; and the same is true of a case where you prevent a man from suffocating by removing a tumor from the larynx. In the strict sense of the word, the most brilliant " cures " are made in such diseases as syphilis ; by antisyphilitic internal treatment, we often cause extensive and old morbid products to dis- appear in a few weeks, as if by magic. But such undoubted cures are rare in other diseases ; we often have to content ourselves with destroying the diseased part, and thus preventing not only the RESISTANCE TO AMPUTATION. 721 spread of the disease to neighboring parts, but also its injurious effects on the general system. The smaller and more unimportant for the life of the organism the diseased part is, the quicker we shall decide upon sacrificing it. The larger the part to be removed, the greater not only the danger attending the removal, but the more effect will it have on the subsequent usefulness of the patient. This brings an unscientific social element among indications for amputa- tion, which is frequently very important. Thus, a rich man could live, and to a certain extent enjoy life, even after losing all four ex- tremities ; for the physiological uses of the limbs may be supplied by the labor of other persons, and labor may be bought. But for any one dependent on the work of his hands or feet, the loss of a limb, or in some artisans the maiming of a finger, may ruin his pros- pects in life. How can a postman, bricklayer, or turner get on without sound legs, or a jeweler or shoemaker with only one hand ? I have often had to remove a finger which had been drawn into the hollow of the hand by a cicatrix, because it prevented the patient from grasping an axe or spade as his business required him to do. How often I have heard patients say : " So you can't cure my foot? I would sooner die than lose it ; for what could I do without it? I am a ruined man ; I cannot stand it ; you shall never take it off ! " But one does not readily die from chronic diseases of the extrem- ities ; the pain, continued for weeks, months, or years, finally wears out the strongest ; and then love of life, and becoming accustomed to the thought of being able to earn a livelihood even after losing a limb, finally decides most patients to submit to amputation, though sometimes not till it is too late. The opposition of severely wounded persons to amputation varies greatly ; it depends chiefly on the appearance of the injured part, and on the amount of pain. If the extremity be torn to shreds, and pieces of crushed bone be seen in it, there will be little opposition to amputation ; the same is true when there are excessive pain and great ecchymosis, and the fingers and toes are immovable. But if this be not the case; if the severity of the injury be only recognized by the surgeon — for instance, if it be a wound of a joint with fracture of a bone, without much deformity or functional disturbance, if the pa- tient can move his toes and fingers and has no pain — it is often dif- ficult to explain to him the necessity for an operation ; it requires confidence in the surgeon as in a superhuman being to induce him to permit amputation. You will often find your surgical notions met by insuperable objections. If, after a few days, the dangerous changes which you may have foretold occur, and the patient begs to be amputated, you may sometimes have to say, " It is too late ; " but 46 722 AMPUTATIONS, EXARTICULATIONS, AND RESECTIONS. will you be so cruel as to say, " I told you so " ? It is a trying mo- ment for the surgeon. If there is the slightest prospect of a cure, even under such circumstances, he will amputate ; the hope of saving under such circumstances a patient who has been "given up " is an evidence of youthful and justifiable pride in surgical power. But when we fail to succeed time after time, and grow weary of trying- for the rare successes, we become more resigned, and watch with re- gret the sinking ship without sending out the life-boat of our surgi- cal skill. Seductive as may be the hope of accomplishing wonders by unusual skill, we must still shun the danger of showing our skill to be impotent. For too many mishaps finally annul in every con- scientious surgeon the pleasure and trust in his art. I hope what has been said will make you think seriously, before any important operation, whether you should operate, and how. You must remember that in any serious operation you require the patient to put his life in your hands, and you owe him your best knowledge and skill. It is difficult to give general indications for amputations and re- sections ; almost any general rule in surgery might be criticised in special cases; but it will be well to epitomize what I have said on these points during the present lectures, and I will add something about the performance of the operations and the after-treatment of the patient. AMPUTATIONS AND EX ARTICULATIONS. In some injuries of the extremities, it is certain from the first that the limb must become gangrenous, or that the consequent sup- puration will be so great as to seriously endanger the life of the patient. But if primary amputation is not submitted to, and gan- grene is far advanced, amputation will probably not prevent death ; and the same .is true in advanced phlegmonous inflammation with septicaemia. The only hope of success is in cases where you can am- putate in perfectly healthy tissue ; for instance, when, in traumatic gangrene which has spread from an injury of the hand or forearm to the elbow-joint, you can amputate high in the arm or at the shoulder- joint. Under analogous conditions, similar operations on the thigh or hip-joint are much less favorable. If conservative treatment has been successfully tried for a time, and then symptoms of pyaemia appear, amputation may be resorted to with some hope of success in the upper extremities, but rarely so in the lower limbs. In these so-called secondary amputations, a favorable result is more probable when pyaemic symptoms have not appeared, but from OCCASIONS FOR AMPUTATION. 723 excessive inflammation the skin has suppurated so extensively that we cannot hope for the wound to close ; or when the patient has fallen into a marasmic state from slow suppuration of large joints or bones. Injuries of the hands or feet may also lead to amputation, when of such a nature that, under the most favorable condition, they would induce a useless, constantly ulcerating stump. After evulsions or crushed wounds especially, the bones may protrude and the stump may require a regular amputation. The results of frost-bite must be treated in the same way; but in the lower limbs we should not delay amputating too long when the line of demarkation has been formed ; sloughing off of considerable portions of the body too often induces septicaemia, which may be prevented by early amputation in cases of gangrene from frost-bite or burns. In acute idiopathic inflammations of bones and joints, by early diagnosis and treatment, we are constantly learning to preserve limbs by making proper openings for the pus, and fixing the limbs in good position. Still, cases do occur where the patient can only be saved by well-timed amputation ; but the choice of the proper time is difficult, as it is a question whether and how long the patient can bear the suppuration and fever. In regard to so-called spontaneous gangrene, or, as old surgeons called it, grangrene from internal causes, we must carefully consider each case. If the gangrene be due to arterial embolism, and there be general disease, the limb should be amputated as soon as demar- kation occurs. In gangrene after typhus and severe exanthemata, we may wait till the patient has somewhat recovered. In true senile gangrene we rarely amputate. If the gangrene be limited to one or a few toes, they may be left to come off spontaneously. If it extend to the tarsus, it is rarely limited to that part ; but should it be, we loosen the protruding bones, and strive, with the least possi- ble injury of the soft parts, to secure enough substance to cover the stump. The chief chronic diseases which give occasion for amputation are the chronic inflammations of bones and joints. Caries of many bones of the carpus or tarsus, of the knee-joint in non-tuberculous adults, of the hip, shoulder, or elbow joints, rather demand resection if any operation is required ; amputation is a secondary question. Extensive incurable ulcers and incurable or frequently recurring pachydermy of the leg often demand amputation, unless the patient is to be condemned to constant pain and to be permanently bed- ridden. Large aneurisms of the femoral artery, especially if likely to rupt- T24 AMPUTATIONS, EXARTICULATIONS, AND RESECTIONS. ure, if they cannot be cured, would certainly prove fatal if amputa- tion were not performed. In tumors of the extremities which are firmly adherent to femur, humerus, or tibia, and grow in between the soft parts, we must am- putate. Tumors merely attached to the ulna, radius, or fibula, and not extending into the soft parts, may be successfully removed by partial resection, or even by removal of the bone. Lastly, amputation may be desirable on account of distortion or malformation of the foot preventing a patient from walking. Now, regarding the method ', we may operate through the joint, or saw through the bones. Both ways have their advantages and objections. Amputation through the joint appears to be the most natural and simple, and least injurious. The soft parts may even unite to the cartilage by first intention, or the cartilage may suppu- rate and be thrown off, in which case the healing is by granulations growing from the bone. The medullary cavity of the bone is not opened, so we escape the possibility of primary infection of the me- dulla at the time of or shortly after the operation. The objections to this operation are, that portions of the serous synovial sac remain and have little tendency to primary adhesions, and pus readily collects in them after the wound has united. More- over, the soft parts required to cover the large articular surfaces are very extensive, so that the wounded surface must be very large. In case of the knee or elbow joint, the length of the flap required is such that we might perhaps make a high amputation of the leg or forearm. The stumps left after exarticulation are unfavorable for the application of artificial limbs ; for instance, after exarticulation at the knee, the joint of the artificial leg would have to be lower than the knee on the sound side. In amputations we have the advantage of being able to choose where we will remove the limb, although, from certain empirical reasons, and for greater convenience in applying artificial limbs, certain places are preferred. We generally require less flap to cover the stump from an amputation than from an exarticulation. Sawing the bone is not a very formidable complication of this operation, although in many cases more or less extensive necrosis of the sawed surface results. If the medulla in its cavity or in the spongy sub- stance be infected by a dirty sponge during the operation, or if the soft parts become so adherent that pus forming in the medulla can- not escape, severe acute osteomyelitis results, which may Induce septicaemia and death. In more favorable cases the osteomyelitis is limited, and we have necrosis of the bone in the stump ; after six or e : ght weeks the necrosed portion may be removed as a sequestrum ; I !■ METHOD OF AMPUTATIOX. 725 a bony envelope has formed around it, which replaces the lost bone. When speaking of complicated fractures, we have already stated that osteophytes may form at the amputated end of the bone. Osteo- myelitis of the stump is difficult to recognize at its onset ; but you may assume its presence if on the third or fourth day after the operation the patient, who has previously been free from fever, sud- denly has a high fever with chills and diarrhoea, while the stump shows no signs of inflammation, or perhaps most of it has healed by first intention, Hence, as the cause of the fever is not inflamma- tion of the soft parts, it must be in the bone, unless there be some ex- ceptional complication. At all events, in such cases you should open the stump and expose the bone, to evacuate any pus that may have formed. Occasionally you may in this way save the patient, but usually it is too late; for, from the uncertainty of the symptoms, we rarely have the courage to lay open the beautifully-healed wound, although it would do no great harm even if we were mistaken in the diagnosis. In amputations and exarticulations the chief points are : 1. To do the operation with as little loss of blood as possible. 2. To arrest the bleeding completely, so that there may be no secondary hagmorrhage. 3. To cover the end of the bone with soft parts, so that they may unite easily and completely. In regard to the first two points, I have nothing to add to what I have already said. Before the operation JEsmarcffs bandage should be applied; the amputation may then be done without losing a drop of blood. After the operation I twist the small arteries, and close the larger ones by acupressure or catgut ligature. After exarticulation of the femur or humerus I ligate the femoral and axillary arteries, because I have found it such slow work to apply the needles securely. The end of the bone must be covered with soft parts, which must heal over it ; if this does not occur, and the bone projects, the granu- lations growing out of it either fail to cicatrize and form an ulcer, or, if they do cicatrize, the cicatrix adherent to the bone has so little vitality that wearing an artifical limb soon makes it sore. This is very unfortunate, as it prevents the patient from using the stump, and condemns him to two crutches and pain in the ulcerated stump for the rest of his days. Hence the bone must be sawed higher up than where the soft parts have been divided. In exarticulations the soft parts must always be divided below the end of the bone. In accordance with these principles, the soft parts may be divided as follows, and properly shaped to cover the stump : 726 AMPUTATIONS, EXARTICULATIONS, AND RESECTIONS. 1. In the circular operation we make a circular incision around the limb, strongly retract the divided soft parts, and saw through the bone ; then, letting go the soft parts, they fall over the end of the bone. To obtain this end most certainly it is well to proceed as follows : First divide the skin entirely around the limb, then dissect it up, leaving as much as possible of the cellular tissue with it, and leaving the muscular fasciae on the muscles. When the skin has been dissected up from two to four centimetres, turn it back like a cuff, and let an assistant strongly retract it with the other soft parts ; then cut through the muscles down to the bone with a circular sweep of the knife, at the line where the skin is turned back ; the assistant then retracts all the divided parts as far as possible ; then with a third circular incision the deep layer of muscles is divided about two centimetres higher than the second cut divided them, the periosteum is divided, and the bone sawed through. If now the parts be allowed to fall into place, three cut surfaces will appear — through the skin, through the muscles, and through the bone, the last at the bottom of a funnel-shaped wound. Where the limbs are thin, the soft parts should reach about six centimetres below the end of the bone ; where the; are muscular, this distance should be two or three centimetres more. In amputating the forearm or leg, the last incision must divide the interosseous muscles before the bone is sawed. It will be best for you to make the circular operation as I have just described it, and accustom yourself to make smooth incisions, and to cut by drawing the knife, not by pressing on it. At the same time, I do not mean to say that the circular operation may not be well done in other ways. Sometimes the following modifications are advisable ; they differ partly in the shaping of the stump, part- ly in the mode of operating : We may amputate a limb in one plane as if done with an axe or guillotine; this may be successfully done on the fingers. In the fingers we prefer exarticulation to amputation ; but sometimes fingers are thus cut off by machines, such as circular saws, straw- cutters, etc., and the question arises wmether the stump will do well without surgical interference : it will do so, but this is merely on account of the anatomical peculiarities of the fingers, where the skin is adherent to the sheaths of the tendons and to the bone, and does not retract, while the tendons retract in the sheath. The cicatricial contraction is concentric, and draws the skin together to the centre of the divided bone, as we might draw a tobacco-pouch. At most other places in the limbs the skin is so movable on the fasciae, and the muscles on the bone, that after an amputation in one plane the METHOD OF AMPUTATION. 727 muscles would retract from the bone, and even the skin would re- tract. After the stump, where the bone projects like the point of a cone, granulates, the force of cicatricial contraction will draw the skin and muscles forward if the latter have not become so united with the bone or skin as to become immovable. As this circular amputation in one plane always leaves conical stumps, it is only done in the fingers or toes. Amputation in two planes is also of limited use. Here the skin is divided and turned back, then the muscles and bone are divided in the same plane ; this leaves the stump covered by the skin only. Where the bone is covered by many muscles, they will retract great- ly, carrying the skin back with them, so that the end of the bone will lie in about the same plane with the skin-flap ; then, in healing, the skin becomes attached to the cone-like section of the muscles, and we have another conical stump. This method is only admissi- ble at points where the muscles will not naturally retract from the bones, or where they and their fascise have become adherent to the bones and to each other from long-continued precedent disease. It may answer in amputations of the leg just above the malleoli or just below the head of the fibula, or at analogous points of the forearm ; but the skin-flap must be made long enough to cover the stump readily. The circular amputation in three planes first described, where skin, muscles, and bone are separately divided, may be done in vari- ous ways. For your first attempts on the -cadaver, I advise your doing it as above described. Instead of the last incision through the deep layer of muscles, you may turn back the periosteum two centimetres from the level of the first incision through the muscles, and then saw the bone ; the effect on the form of the stump remains the same, whether the deep part of the funnel is covered by perios- teum or muscles. This method may be done somewhat quicker and more elegantly if, instead of the three incisions in different planes, you divide the skin, and then have the assistant strongly retract the parts, while you divide the muscles by thin layers. With some practice you will learn to make the funnel just the depth you desire. But if your assistant retracts the soft parts too energetically, and you divide only thin layers, by the time you get down to the bone you will have gone too high, and will have too much flap. If the assistant retracts too feebly, or if the soft parts are adherent to the bone and do not move freely, while you cut rapidly and deep, you get too little covering and have a conical stump. Lastly, the funnel has been made by cutting obliquely from with- out inward to the bone. But these methods are not practical, and I will give no further details. 728 AMPUTATIONS, EX ARTICULATIONS, AND RESECTIONS. The circular cut is the normal method for all amputations; it is applicable to any part of a limb, although for exarticulations flaps or oval sections are more practical. 2. Flap Operations. — From the soft parts we make one or two flaps with which to cover the sawed bone. If we make one flap, with a base half the circumference of the limb at the point of am- putation, on the other side we usually make a circular cut in one or two planes. In flap-amputations, also, it is desirable before sawing the bone to turn back the periosteum about one centimetre, and to saw the bone about two centimetres above the base of the flap, so that as the muscles retract the end of the bone shall not press too much against the inner side of the flap. I prefer making the flap so that while the patient lies in bed it shall hang over the wound without being held by sutures. The lower part of the flap should be of skin, the upper of skin and muscles. The best way of doing this is first to form the flap by an incision through the skin, then retract the skin and cut down through the muscles to the bone, then by two incisions make a cir- cular cut on the posterior part of the leg. The length of the flap should be about one-third the circumference of the limb at the point of amputation, and its breadth about one-half the circumference, or rather more. The single flap has the advantage that where the cause for am- putation, the injury or ulcer, or the line of demarkation in gangrene, is irregular in outline, we may amputate lower than when we per- form a circular operation, so that the stump may be longer and the prognosis better. I do not think the operation with two flaps has any advantage over the circular method. We may make two lateral flaps, or an anterior and posterior one, provided the amount and form of the soft parts is analogous to the circular amputation. Occasionally in- filtration of the skin prevents its being retracted well or turned back ; then we may incise it in the direction of the long axis. This would make of the circular an operation with skin-flaps, having* the funnel shape within. Flaps for covering the stump with skin alone are not good, for long flaps of this kind readily become gangrenous at the edge, and, there being no muscular layer between the skin and the sawed end of the bone, the latter readily causes ulceration and perforation of the flap. It is true, this is no great misfortune, as the exposed por- tion of bone either necroses and separates, or soon granulates and cicatrizes ; but in either case the cicatrix becomes adherent to the bone, and the subsequent use of the stump may give rise to tedious ulceration. METHOD OF AMPUTATION. 729 The method of forming the flaps by transfixing- the limb with a long, pointed knife, and then cutting-, usually results with beginners in making a muscular flap, which is occasionally tongue-like, is cov- ered with too little skin, and does not well cover the wound. If before entering the knife we have the skin strongly retracted, and pass the knife flat alongside the bone, we may make good flaps ; but it requires more experience and practice than the former methods. Flap operations are possible at any part of a limb, but are not everywhere advisable. By drainage-tubes we may lead off the secre- tions, even in flaps formed from below. If the flaps do not unite by first intention, the after-treatment is always tedious; for we have to guard against cicatricial contraction rolling them in. 3. Finally, in a third method, the wound made is between a circle and a flap ; it is called the oval amputation. The plane of incision of the oval lies obliquely from above down ; the upper part of the oval is more pointed, the lower more rounded. After making the in- cision through the skin, it is to be drawn back, and the soft parts and bone are to be divided, as in the circular operation. For am- putations the oval incision is rarely used, as it has no advantage over the circular or flap operations. In exarticulations of the fingers and toes at the metacarpo- and metatarso-phalangeal articulations, or of the big toe or thumb, the oval incision is very useful. In exarticula- tions at the shoulder or hip joint, I would only employ this method when there was not skin enough to form a flap. I have still something to add in regard to preparations, assistants, choice of instruments, and after-treatment of amputations. While the patient is being anaesthetized, or previously (for it is hard to bring some patients under anaesthesia when their attention is excited by manipulation of the affected part), we carefully cleanse the part with soap and water, especially at the point of operation. Then the bandage for preventing haemorrhage is applied, and taken off again except the upper band. Now one assistant holds the up- per part of the limb, another the lower. In amputations the operator stands so that he may assist in retracting the soft parts, and that the part to be amputated falls to his right; in exarticulations he should stand so that he can himself, w 7 ith his left hand, control the move- ments of the limb to be removed. For amputations and exarticulations of the toes, we use small knives with blades four or five centimetres long; they should not be too much curved in front, or the point will not enter the joint readily. For exarticulations of the hand and foot, as well as for amputations 730 AMPUTATIONS, EXARTICULATIONS, AND RESECTIONS. of the lower half of the forearm and leg, we choose a knife with a blade about 15 centimetres long ; for the upper part of the forearm, the arm, upper part of the leg, and the lower part of the thigh, the blade should be from 15 to 25 centimetres long ; for high amputa- tions and exarticulations of the thigh, it should be 25 to 35 centi- metres long. If you have two small knives with blades 5 centi- metres, and one each of 15, 25, and 35 centimetres, it will be enough. In amputating I do not like changing knives, and so prefer having the cutting edge somewhat rounded in front, so that the skin may be dissected up with tha point of the same knife. Other operators prefer doing this with a scalpel, then taking another knife to divide the muscles, and still another for the periosteum. For pushing back the periosteum, I use a raspatorium, though sometimes this may be done by the nail alone. A skilled assistant will with his hands re- tract the soft parts sufficiently to give the operater room to cut and saw; but pieces of clean linen may be used for this purpose. Some operators take pride in amputating even thick limbs with small knives, thus pushing the simplicity of instruments to the utmost point. These points, while not unessential, depend greatly on habit and tradition, and each one maj^ follow his own taste. Saws for amputation are usually bow-shaped. The bow should not be too high, or it will make the saw unsteady; the handle should be broad and lie securely in the hand. The blade should not be more than two centimetres broad, and the teeth should be bent out- ward, else the saw will catch ; and it will be still more apt to do so if the assistant holding the lower part of the limb raise it instead of depressing it somewhat. After sawing the bone, I usually cut off the sharp edges with bone-nippers. When the amputation is completed, the vessels are twisted, com- pressed with needles, or ligated ; the instruments required for this should be all ready. In one of these ways we first close all the ves- sels we can find, then relax the elastic band or tourniquet, doing it in such a way that the assistant can renew the compression if the bleeding becomes excessive ; then we apply acupressure or ligatures to any other arteries we see bleeding. In amputations of the thigh or arm we may have venous haemorrhages, as the valves are insuffi- cient. The veins may be ligated or compressed by needles ; torsion of veins is dangerous. Arterial hemorrhage from the medullary cavity of bones is very unpleasant ; it is rarely severe. But either poking into the medulla with forceps or firm pressure with a sponge is dangerous ; and we should entirely avoid the application of styp- tics, especially liq. ferri. I advise letting the bleeding alone till all other vessels are cared for; if by that time it has not ceased spon- AFTER-TREATMENT OF AMPUTATIONS. 731 taneously, we may compress the main artery of the limb for a while with the finger. During the dressing we should only use new, soft sponges. We should wait till the bleeding is entirely arrested ; it is even desirable to leave the wound exposed to the air for a time. After circular or oval amputations, the wound is generally united in a ver- tical direction. I apply from two to four sutures in the upper part of the wound, leaving the lower part open. I secure . flaps in the position they are to occupy by from two to four sutures, previously placing a drainage-tube dipped in glycerine in the wound across the bone, so that the two ends project from the angles of the wound. The stump should be so placed in the bed that the secretion from the w^ound will flow into a basin placed beneath without soiling the bed. After two days acupressure-needles may be removed, and after six or eight days the drainage-tube. In cases running a normal course, the stump should not swell nor the patient become feverish. After ten to fourteen days the parts which have not healed may be covered with disinfected charpie and a bandage applied, so that the protecting frame may be removed from over the limb and the patient move more freely in bed. Should the stump swell, or the patient become feverish, the ad- hesions of the wound should be broken up with the finger, and any pus that has collected be allowed to escape. If there are neuralgic pains or frequent twitchings, subcutaneous injections of morphine may be made. If arterial secondary hemorrhage occurs within twenty-four hours, the artery should be sought for and closed ; if it comes later, in the second or third week, when the wound is granulating, it is best first to seek the bleeding point and close it firmly ; if this attempt is un- successful, and the haemorrhage recurs after prolonged digital com- pression, the main artery of the limb should be ligated. After amputation, many surgeons prefer closing the wound care- fully at once, and applying a bandage to hold the soft parts against the bone ; other surgeons fill the wound with charpie dipped iu styp- tics, and unite the soft parts over it by a bandage, which is not loosened for forty-eight hours. I have not seen good results from either plan. Neither the attempt to force healing by first intention nor the endeavor to secure profuse suppuration from the first is good. Complete union by first intention may occur in the open treatment ; and if suppuration occurs, the pus can escape readily if adhesion does not take place too soon. The surgeon should learn by observation to detect this. In Listens method the wound is completely united, but drainage- 732 AMPUTATIONS, EXARTICULATIONS, AND RESECTIONS. tubes are inserted and light compressing' dressing applied, which at first is to be replaced whenever it becomes saturated with blood and serum. Lately I have treated some amputation-stumps by Listens method with good results ; most German surgeons employ this method exclusively after amputations. Treating the stump in the water-bath was attended by so many difficulties that it was soon given up. When treating of circular amputations made in one plane, we spoke of the unfortunate occurrence of conical stumps. They may be due to unsuitable incisions through the soft parts or deficiency of soft parts ; but these are not the only or even most frequent causes. In marasmic patients there is sometimes such an atrophy of the soft parts of the stump that they grow thinner and shorter, and sink more and more on the bone ; this is particularly the case at the lower end of the femur, where few muscles are inserted and none originate. Moreover, where the covering was plenty, inflammation and suppura- tion of the stump induce subsequent atrophy, which retracts the soft parts so much, and so attaches them to the bone, that they cannot be brought into place by the cicatricial contraction of the granulating wound. This is the most frequent cause of conical stumps. As in- flammation cannot always be prevented, the operator is not always responsible for conical stumps. One might think this could be avoided by providing for plenty of flap to cover the stump ; but an excess of flap is also objectionable. If we make long skin-flaps, their ends become gangrenous ; the loss of substance thus entailed is not the worst of this, but we should try to avoid the decomposi- tion thus induced. If we have made too long a funnel of muscles, there is another objection; that is, the flap is so heavy that its weight presses it strongly against the edge of the bone ; we can to some extent prevent this by placing a splint under the stump to support it. If We see that a conical stump is forming, we may apply adhe- sive plaster and weights, as in coxitis, to draw the skin down, or at least to aid the concentric contraction of the granulating surface by freeing it from the opposition. If the patient . bears this without pain in the stump or fever, it may be of benefit; but if these symp- toms appear, it must be abandoned. If, as a result of osteomyelitis, extensive necrosis of the stump occurs, it is indeed shortened, but the osteophytes which have formed prevent too much shrinkage, and they do not atrophy for years. My experience does not show that the stump becomes less conical by the detachment of the seques- trum ; usually an operation is required. I split the mass of granula- tions upward into the skin and downward to the bone, then push the AFTER-TREATMENT OF AMPUTATIONS. 733 raspatorium along the bone, separating the periosteum and osteo- phytes from the bone so far into the soft parts that they may cover the stump of bone which shall be left. In sawing, I use a chain-saw whose ends I bring out above while the loop is around the bone. In limbs with two bones, this subperiosteal resection or amputation is done on both bones. Care must be taken that the secretion from the periosteal canal from which the bone is removed has a free escape ; it is much inclined to close in front by first intention ; then pus may collect deeper in, decompose, and cause osteomyelitis. I had such an unfortunate case in the army-hospital at Mannheim, in a soldier who was amputated successfully for a severe injury of the knee, and finally died in this way. At that time I did not know of this danger from subperiosteal resection of an amputation-stump, all the previous cases that I had operated on in this way having done well. Observation of old amputation-stumps shows that they change considerably in the course of years : some grow very thin ; the mus- cular covering or flaps atrophy from disuse, so that only the skin remains. In the course of years most stumps become conical even if covered with skin alone. This is the more certain to occur, the more poorly nourished and marasmic the patient, and especially in those who have been amputated for caries of the joint, and who subse- quently have caries of other bones or in the stump, or pulmonary tuber- culosis or lardaceous disease. The bones of such stumps atrophy, and their cortical layer becomes thin. Short thigh-stumps are about the only exception. If these are used much in walking, the muscles going from the pelvis to the thigh develop, the skin and cellular tissue participate in the good nutrition, and the stumps become larger than they were shortly after the operation. From most old amputation-stumps being covered only by skin, while the muscles have disappeared, some have asserted that it is entirely useless to employ muscle for covering the stump ; but we have already shown that they would not heal so well. In Lecture IX. we treated of neuromata in the amputation- stump. Regarding the prognosis for amputations, we can only say in general terms that they are the more dangerous the nearer they are to the trunk. Much depends on the general condition of the patient at the time of operation. Amputations for injuries are always less successful than those made for chronic diseases; but in each case there are many points that we will not lose our time about here. Surgeons pay too little attention to the subsequent fate and the artificial limbs of those they amputate. You will hear many com- •734 AMPUTATIONS, EXARTICULATIONS, AND RESECTIONS. plaints from these patients. Pains in the stump with each change in the weather, excoriations of the cicatrix, pressure of the artificial limb at one place or another, and constant repairs of it, are the most frequent complaints. Some suffer for years from the sensation of still having their limb ; for instance, after amputation of the thigh they exclaim : " I have a pain in the little toe ; the big toe is being torn ; my foot lies in a bad position," etc. During the first days and weeks after amputation these sensations are the rule, and are so decided and strong that by covering the stump we may deceive patients for weeks about the loss of their limbs ; but I have seen patients who had the same sensations after years. As regards the substitute for the limb, much depends on the patient's position in life and his means, not only for baying a limb, but for keeping it in repair and replacing it when worn out. Artificial arms and well-imitated hands are articles of adornment and luxury. Active movements of the fingers have not been attained, but mechanism for grasping has been arranged with springs which are opened by the other hand. I will not enter into more detail. For the arm or forearm, a workman may have a leather case held in place by straps, and having a solid piece of wood at its lower end, into which may be fastened hooks, etc. On Sunday he may put on a hand carved from wood. It is astonishing what intelligent persons can accomplish with such apparatuses. I have a long, beautifully- written letter from a man for whom I amputated both hands. He was an engineer, and got his hands caught and crushed in a rapidly- revolving water-wheel. Subsequently, without hands, he earned his living by writing. As regards the lower limbs, there are few stumps on which the patient can bear the entire weight of the body ; and these are the stumps after amputations and exarticulations of the foot, and some- times after exarticulations at the knee. In all other cases the pa- tients rest on the condyles of the tibia or tuber ischii, which bony parts are supported on a firm, cushioned ring, which forms the upper end of the shield of the artificial limb, and into which the stump is introduced. After amputations of the leg, it is desirable to divide the weight of the body on these two points. Another way is for a patient whose leg has been amputated to rest the bent knee on a wooden leg; this, of course, prevents any motion at the knee-joint. In regard to the construction of artificial limbs and wooden legs, I will say nothing, except to add that for their use a certain amount of skill and intelligence is required, as well as pecuniary means for attending to the repairs so often required by any artificial limb. Hence, for working-people, as most of our hospital patients are, it PROGRESS OF AMPUTATIONS. 735 is better to have firm wooden legs. Even many from the higher classes, who have been amputated, and have worried over artificial limbs for years, finally resort to wooden legs. Walking with an ar- tificial leg and a wooden one differs so much, that one who has been accustomed to the latter for years can only use the former after very patient trial. Simple as the operations for amputation and exarticulation now seem, we must remember that from Hippocrates to the present time progress has constantly been made in them. That large portions of limbs could be lost without danger to life was first taught by their spontaneous detachment by gangrene ; the first amputations were made for the purpose of removing such gangrenous limbs, and the bone was sawed at the line of demarkation. The indications for amputation grew very slowly. What especially retarded the intro- duction of this operation was not knowing how to check the haemor- rhage with certainty ; styptics and the hot iron answered for the leg and forearm, but not elsewhere. Hence the progress of ampu- tations depended on that of the methods for arresting haemorrhage. The greater amputations were only ventured on after the introduc- tion of the ligature and tourniquet. The method of amputating limbs by strangulating them with a ligature was first introduced by Guy de Chauliac and improved by Ploucquet. Of late this method has been tried again by the bcraseur (Chassaignac), the galvano- caustic ( Von JBruns), and the elastic ligature (Dittel), but has met with little popularity. Later surgeons particularly directed their attention to amputating as rapidly as possible, so as to cause the least pain, and to dividing the soft parts so as to avoid conical stumps. Now that we have anaesthetics, and. can avoid haemor- rhage by the elastic bandage, rapidity in amputations and exarticu- lations is a matter of small moment. Attention is turned to the formation of the stump, and since the beginning of this century to attempts to secure healing by first intention, and especially to the avoidance of any infection from without or from the secretions of the wound, and to escaping pyaemia, the most dangerous enemy of amputations. The latter points now chiefly claim our attention, and recent proposed changes in the method of operating all have them in view. The first method which was used in Celsus's time was a circular incision with retraction of the skin. This was gradually improved on. Loicdham (1679) is usually regarded as the originator of the single flap, which method was perfected by Verduin (1696). Hava- ton and Vermale are said to have been the first to use two flaps. 736 AMPUTATIONS, EXARTIOULATIONS, AND RESECTIONS. The oval amputation was first made by Scoutetten. You will find very accurate accounts of amputations in SprengeVs histories of operations, and in JLinharfs excellent work on operations, which I cannot too highly recommend. RESECTIONS. I will now make a few general remarks on resections. As previ- ously stated, sawing, chiseling, or gouging out diseased or injured pieces of bone from the body of the bones, is called " resection in the continuity." Most operations of this nature were mentioned when treating of complicated fractures, necrosis, or caries ; as were the so-called osteotomies for orthopedic purposes. You will see these operations so often in the clinic that I will not describe them here; they are mostly simple. The indications for them appear from what has been said. We have also spoken of " resections of joints." I have already told you that these operations, which in civil practice occur espe- cially for caries, have different results and indications for each joint. The same is true of resections of joints in gunshot-wounds ; each joint has its special resection history. Resections, especially resec- tions of whole joints, are of much more recent date than amputations. The first excision of a carious head of a humerus was made by White, 1768 ; resection of the elbow- joint by Moreau, 1782 ; of the head of the femur by White, 1769; of the knee-joint by Park, 1762. But at first these operations were not popular ; they were said to be too difficult, tedious, and painful, and it was thought that the final results would not be good. It is only within the past thirty years that they have been accepted by surgeons, and the methods of their performance are still being improved. At first it was merely at- tempted to remove the affected portion of bone without loss of the limb, so that the parts might heal. Later, attempts were made to retain the function of the false joint left after the resection, by judicious selection of the lines of incision, method of operating, and after-treatment. Surgeons even went so far as to excise stiff joints that were all healed, so as to substitute for them movable false joints. Possibly, for a time, we held too hopeful views of what was attain- able by these operations; but wonderful cures have been accom- plished, and with the increased attention now given to them we may expect the indications, mode of operating, prognosis, and after- treatment to be more defined. In resections, the incisions should be so directed that no large vessels or nerves, and as few muscles as possible, may be injured, and still space made for freeing the joint and sawing the bone. RESECTIONS. 737 When these operations were first done, they seemed so difficult that it was thought the joint should be exposed by large, deep flaps, so that ligaments and muscular insertions could be readily divided, and the ends of the bones sawed off. Later, as more was thought of making a useful joint, the operation was more carefully made ; oblique sections of tendons and large wounds were avoided; the periosteum was preserved as much as possible, and also its connec- tion with the muscular insertions, by using the raspatorium instead of the knife ; and in chronic inflammations operations were done in the thickened tissue, where they were followed by less inflammation and febrile reaction than in healthy parts. JB. von Langenbeck, more than any one, developed the indications for resections of joints, and perfected the methods of performing them ; he also introduced the simple longitudinal incision, which is now generally used for resec- tion of the shoulder, elbow, and hip ; for the knee an anterior flap is made, with a broad base above. The instruments used for resections, except the chain-saw (of Jeffray), are the same as recommended by Von Langenbeck : a strong knife, five to seven centimetres long, with straight edge and thick back ; this knife is introduced to the bone, and the entire incision made at one stroke ; with a broad, small, more or less curved, half- sharp raspatorium, the periosteum is scraped from the bone; the articular ligaments and some muscular attachments cannot always be detached in this way, and have to be divided close to the bone. When the ends of the bone have been entirely denuded of soft parts, they are sawed off, being held by bone-forceps, while the soft parts are held back with blunt hooks. Sharp edges of bone are to be removed with bone-nippers. Before the operation the patient is anaesthetized, and the limb to be operated on is rendered bloodless by the elastic bandage and carefully cleansed. After the operation the haemorrhage is to be carefully checked, and the wound washed with new, clean sponges ; then the limb is placed in an apparatus to keep it perfectly im- movable, but not too tight, allowing the wound to be free and the secretion to escape readily ; the patient's position should be easy, and changed without disturbing the dressing. I have not found it w T ell to fill the wound with charpie and apply a bandage before loosening the pressure above the wound ; for in so doing the whole bandage is so filled with blood that it must be soon renewed. I prefer first checking the bleeding completely by liga- tion, acupressure, ice-water, etc. ; then I introduce drainage-tubes, dipped in glycerine or carbolic-acid solution, to conduct the secretion into vessels placed beneath. 47 738 AMPUTATIONS, EXARTICULATIONS, AND RESECTIONS. When possible, I apply a plaster-of-Paris bandage before the operation, make openings of the proper size at the point of opera- tion, then slit the bandage down one side when it is dry and remove it for the operation, and have a plaster shell to put on after the operation, iri whidh the limb can be suspended or laid on a JRis's supporting splint. Other operators prefer prepared wooden or iron splints ; the same end may be attained with the most varied ma- terials. After resection of the hip-joint no bandage is usually re- quired, extension by weights answering the purpose. In some cases I have found Lister's dressing very useful. Resect ion- wounds are always rather complicated excavated wounds; they always heal by granulation and suppuration after a long time. This is bad for resections in feeble, marasmic patients ; moreover, in such patients we are never certain that caries will not attack the adjacent bones or the sawed surface, or- that the wound will not ulcerate. The shortest time for healing after resection will probably be two or three months. Indolent fistulae often remain for months or years. Recently great attention has been paid to the final result of re- sections of joints. The resulting false joints may become so relaxed that they cannot be actively moved, and the limb hangs useless ; other loose joints are somewhat movable ; then there are joints which have nearly normal mobility and power ; and lastly, anchy- losed joints, which are nevertheless more useful than the first men- tioned. The final result depends greatly on the amount of bone removed, the amount of regeneration of bone, the care observed in dividing the muscular insertions, and the muscular power of the patient ; it is also greatly influenced by gymnastic exercises, electricity, baths, and application of suitable apparatus. But as these vary with the different joints, and different methods and apparatus are required, these matters can only be explained when treating of resection of individual joints. Prognosis as regards life is the same as in amputations. Resec- tions on account of caries usually run a more favorable course than those for injuries. The danger increases with the proximity to the trunk. APPENDIX. ADDITIONS FROM THE EIGHTH GERMAN EDITION. 1.— P. 33. To avoid the danger from venous congestion after constricting the limb, before applying the tourniquet we may apply a bandage firmly to the extremity from below upward, and thus press the blood out from the limb. Formerly this procedure was applied to limbs about to be amputated, and thus the haemorrhage was reduced to a minimum. Grandesso Silvestri, a physician of Vicenza, rec- ommended elastic bandages for this purpose, and instead of the tour- niquet applied a thick elastic tube several times around the limb. In ignorance of this advice, which was little known, JEsmarch re- sorted to the same method, and called attention to the great bene- fits derived from it ; since when it has become very popular. In fact, by means of this appliance long operations may be done without loss of blood. The extremities may be rendered bloodless and kept so for an hour without injuring their vitality. After ligat- ing all the visible vessels, the elastic tube is to be loosened, and the blood will again enter the vessels ; if any more then permit the escape of blood, they may be ligated. This method of making a limb bloodless and keeping it so is a great advance in modern sur- gery ; and by this means operations may be done which without it we should not have dared to attempt. 2.— P. 37. Recently I have tried the Penghawar Djambi a few times, and can testify that when quantities of it are pressed firmly on the wound it acts better than charpie as a styptic ; I will not pretend to say that it is better than liquor ferri, but it smears the wound less, even if left 740 APPENDIX. on for some days. Penghawar Djambi is the light yellowish, soft, hairy substance from the trunk of the Cibotium Cuminghii, a native of the East Indies. [This must closely resemble the styptic cotton so commonly used by us. During the past year, 1878, Pa- quelin's cautery has been used a good deal, and is very convenient. By a hand-bellows a stream of benzine vapor is thrown against a platinum cap which has been previously heated in a spirit-lamp ; after it has once reached a red or white heat, it is easily kept at that point by the benzine vapor. It is readily used, and when at a white heat its application is not painful. For haemorrhages from the vagina or uterus, water at a temperature of 110° Fahr. may be in- jected for some time by means of Davidson's syringe.] 3.— P. 57. Observers, who have of late persistently studied these questions, refer the continued capillary dilatation in acute inflammation to changes in the capillary walls, which are caused directly by the inflammation. Cohnheim claims that inflammation affects the walls of the vessels peculiarly, so that they are not only distended by the blood, but also become softer, of which more hereafter. Samuel ascribes inflammation to changes in the relations of the blood, walls of the vessels, and tissue to each other. Up to the present we have not succeeded in finding accurately the chemical and physical changes in the walls of the vessels, which are known only by their results. This view is an advance beyond Lotzds view (according to which the molecules of the capillary walls separated from nervous irrita- tion), inasmuch as no nerve-action seems to occur in this capillary dilatation developing in acute inflammation. This also corresponds with the demonstrations of Schiff, already mentioned, that the vas- cular dilatations forming after division of the sympathetic are not inflammatory, nor do they lead to inflammation without some fur- ther cause. 4.— P. 69. In his history of plastic operations Zeis has collected all published cases of reunion of parts that had been entirely separated. Rosen- berg has completed this list to the present time, and gives a number of cases carefully observed by himself where portions of noses and fingers which had been cut off reunited. He confirmed previous ob- servations that the epidermis and occasionally small portions of the surface of such parts became gangrenous, while healing went on below. ADDITIONS FROM THE EIGHTH GERMAN EDITION. 741 5.— P. 93. Samuel, who in his last work on fever in general agrees in the etiology above given, and refers the increased temperature to in- creased irritation of those nerve-centres which cause production of warmth, denies the existence of a pyrogenous poison, and brings up some strong points against it ; he thinks that the blood-change which is the final essence of fever is always the same, in spite of the variety of forms under which it appears. To prevent the introduc- tion and removal of blood and water, etc., from being regarded as pyrogenous actions in the broad sense, he supposes a similar decom- posing tendency of the blood to exist between the products of in- flammation, the above-mentioned and other influences, and the ner- vous centre which is to be excited ; and this is termed the true final pyrogenous factor, the essential element of fever. 6.— P. 126. The recent investigations on the formation of vessels by Arnold, already spoken of, as well as those on tubercle, of which we shall hereafter speak, have given new material for the view that the sub- stance of the wall of the vessel as well as its endothelium takes an active part in the new formation ; and in a recently published work of JRieclePs it is stated as very probable that the greater part of the young tissue formed in a thrombus proceeds from the endothelium. Thus the views on this subject have been unsettled for years. 7.— P. 186. Fracture does not always result from the action of a strong direct force on a bone ; the injury may vary from contusion of the perios- teum to crushing of the bone. There may have been merely com- pression of the periosteum, or the force may have bent the bone, which sprang back to its normal shape without breaking ; but at the same time the medulla may have been greatly crushed. In the spongy substance there may be slight breaks or bends, which are never entirely dissipated, even though the cortical substance has not perceptibly changed its form. All these injuries of bones resulting from strong compression are classed as contusions of bone. Concus- sion of bone may result from either direct or indirect force, and be marked by ruptures of the medulla and haemorrhages. After these injuries, pains and disturbance of function are greater than after injuries of the soft parts ; a certain diagnosis of the grade is often impossible at first. Occasionally concussions of bone with contusion 742 APPENDIX. (as in falls on the great trochanter) result in long-continued ostitis, which is not often accompanied by suppuration, but by formation of osteophytes, sclerosis, and protracted impairment of function, which in old persons may prove permanent. 8.— P. 235. Some surgeons praise very highly rubbing and kneading of the extravasation of blood immediately after the injury ; this is an old popular remedy, used even by the Grecian gymnasts ; now it is called massage. Wonders are told of the efficacy of this treatment, espe- cially in regard to rapid reabsorption and restoration of function. The resolvent effect is particularly noticeable in the first four or six hours ; later, when acute inflammation has already occurred, I would recommend it less ; but when this stage is past, it may be more energetically employed. Unfortunately, even after the most careful treatment of sprains, chronic inflammations occur, which are not only tedious on account of their duration, but, continuing through years, may lead to de- struction of the joint ; this is more apt to occur in children or feeble persons of scrofulous diathesis. We shall again refer to this when speaking of the etiology of chronic inflammations. 9.— P. 275, Recent investigations of Samuel show that after certain grades of freezing there is a true inflammation which goes on to regular gangrene. From clinical experience I knew that in such cases there is a process not found in burns ; for parts badly burned, even when not turned to cinder, shrivel up, and the blood coagulates in the vessels, so that other blood cannot enter them even if they continue to exist. If a frozen limb thaws for a time, arterial blood may again enter the vessels, and the question will be whether the walls of the vessels can still keep the blood fluid and the tissues use up the blood coming to them. If this be so, the frozen limb may regain its vital- ity ; if it does not, gangrene occurs. In this transition stage the veins are much distended, and this may facilitate thrombosis in them. Bergmann recommends particular attention in the treatment of this stage ; he has had unusually good results from vertical suspension of the limb, which favors the return of the venous blood. 10.— P. 284. This limitation of the process to the skin and subcutaneous cellu- lar tissue is very characteristic of fibrinous (diphtheritic) inflamma- ADDITIONS FROM THE EIGHTH GERMAN EDITION. 743 tions ; so that on this account, as well as from the hard infiltration and necrosis of the tissue once infiltrated, I do not hesitate to con- sider carbuncle as a diphtheritic inflammation of the skin. I have had no opportunity of examining to see if there are micrococci in the freshly-expressed juice of carbuncle ; finding a few of them in the exposed shreds of necrosed tissue would prove nothing about the ori- gin of the carbuncle. ITochmann thinks that carbuncle as well as furuncle originally develops from a sweat-gland, or from several ad- jacent glands. J. Neumann distinguishes between carbuncles from sweat-glands and from cellular tissue. I cannot say whether there is any justice in this distinction, as I too rarely see carbuncle in its first stages. 11.— P. 285. The inflammation here described cannot be considered exactly as carbuncle ; it is rather a carbunculous inflammation of the skin and subcutaneous tissue, which I should now prefer to call diphtheritic phlegmon ; the accompanying erysipelatous redness also corresponds with diphtheritis. 12.— P. 286. The great difference of the constitutional symptoms in carbuncle agrees very well with the supposition that they are of diphtheritic nature, where it is characteristic for the local extent not to corre- spond to the general toxic symptoms. I do not know if paralyses ever occur after carbuncle, as they do after pharyngeal and laryngeal diphtheria. 13.— P. 286. Possibly patients attacked by carbuncle were only apparently well ; they may previously have had diabetes of a mild grade, with- out its existence having been suspected by themselves or their phy- sician. 14.— P. 296. You will often hear that early incisions in phlegmonous inflam- mation will prevent the skin from becoming gangrenous or suppu- rating. Unfortunately, I cannot confirm this. I have found it to depend more on the intensity of the inflammation than on the ten- sion of the skin. Still, I consider early incisions proper in phleg- monous inflammation, as it seems that by carefully pressing the serum out of the inflamed tissue we may sometimes arrest the pro- gress of the affection. 744 APPENDIX. 15.— P. 297. The abnormal position of extremities after abscesses in muscles have healed is due to formation of cicatrices and their imperfect dis- tensibility. 16.— P. 306. My saying that I could not imagine an acute inflammation of bony tissue has caused some misunderstanding. In acute inflamma- tion of bone no changes are observed in the (fully developed) osseous tissue, but only in the medulla and periosteum and their vessels. I do not underestimate the chemical changes (disturbances of nutri- tion) which go on in the tissues during inflammation ; but we do not know them : we only conclude they occur from the changes we see in the tissues. We see that inflamed connective tissue swells, becomes cloudy, is infiltrated by wandering cells, softens, and finally breaks down into pus ; and all this occurs within a few days. In bony tissue we see' none of these changes ; we do not see that it swells in acute inflammation, or that its interspaces (except the Haversian canals) fill with wandering cells ; and we know that it does not suddenly break down into pus. We only know one termi- nation of acute inflammation of bone, that is, death — necrosis ; be- sides this, it may pass on into chronic inflammation. Hence we can only say it is probable that in acute inflammation of bone changes of nutrition occur, as in that of connective tissue ; but there is, or rather from the nature of bone-tissue there can be, no morphological expression for this change. 17.— P. 316. At the opening of this chapter I said: "The immediate cause of death of individual parts of the body is always the complete cessa- tion of the supply of nutriment, mostly due to arrest of circulation in the capillaries." This admits the possibility of gangrene occur- ring in tissues where capillary circulation still continues. Formerly this seemed to me impossible ; I could not imagine a dead gangre- nous tissue with capillary circulation. But observations at the bed- side, together with the impressions derived from SamueVs investiga- tions of inflammation, have made it seem to me probable that the inflammatory disturbance of nutrition of which we have spoken occa- sionally starts up and extends so rapidly that it leads directly to arrest of the vital change of tissue, even before the occurrence of stasis and coagulation in the capillaries ; the blood then circulates in ADDITIONS FROM THE EIGHTH GERMAN EDITION. 745 tissues which fulfill no normal function of interchange of tissue, but in which the juices are being decomposed in an abnormal way, which may even be the same as putrefaction. Paronychia and more rarely phlegmons sometimes pass so rapidly to gangrene, that from analogy with other processes it seems very improbable that they should be due to arterial thrombosis ; when the tissue has become gangrenous, the capillary circulation soon ceases, but not from disturbance of the circulation in the arteries and veins, as in gangrene from incarcera- tion, but from arrest of function of their walls from the inflammatory process, which I regard as a higher grade of the inflammatory altera- tion (Cohnheim) that takes place rapidly in such cases. It seems that such a rapid change from inflammatory alteration to destruction of tissue is particularly apt to follow septic poisoning ; possibly snake- poison acts in the same way. More of this hereafter. Here we must again mention the fibrinous infiltrations of the cellular tissue (diph- theritic phlegmons). Some clinical observations seem to show that fluid blood can continue to flow for a time through the vessels of tissues whose juices have nearly hardened, that in some of these cases the thrombosis is only the result of the infiltration of tissue, and that the tissue sometimes dies before the circulation is fully arrested. At present we cannot fully explain this symptom ; I only wished to induce you when opportunity offered to attend to these practically important processes.. The view is not new, for the old surgeons regarded gangrene as the highest point of inflammation. 18.— P. 355. Besides the mechanical cause of the compression, which favors coagulation, in inflammation of any tissue there is another factor having the same effect, namely, the changes in the intima of the vessels, especially of the veins. If we do not know the positive chemical conditions under which the blood in the vessels must coag- ulate, since the classical investigations of JBrucke we do know that the normal living intima of the vessels has the special property of keeping the blood fluid, and that coagulation occurs when the intima loses its normal qualities. But in the veins, as in the capillary walls, it loses its normal qualities through inflammation, as is shown by the more recent investigations (see Lecture XXII.) ; these show, indeed, that the inflammatory alteration of the walls of the vessel does not of itself at first induce either complete stasis or thrombo- sis ; however, it is not improbable that the latter is at least favored by the alteration of the walls of the vessel. Hence, the recent views on inflammation would, in some cases at least, confirm the old view 746 APPENDIX. that inflammation of the walls of the veins may cause thrombosis (even without leading to abscess in their walls) ; but further inves- tigations in this direction are desirable. Clinical observations also speak in favor of such a course ; for it has been proved that peri- phlebitis (analogous to perilymphangitis) often precedes phlebitis and thrombosis. 19.— P. 361. Then you will also be told how to distinguish small lobular infil- trations of the lump, such as occur in purulent bronchitis, from me- tastatic abscesses. I will merely mention here that where a venous thrombus opens into the wound, it may remain firmly organized while its upper part suppurates, breaks down, and is finally swept into the circulation by the neighboring branches in which the blood circulates ; this is the only case where pus from the veins enters the circulation without there having been haemorrhage. After death we recognize this process by finding fluid blood or fresh post-mortem clots in the thickened veins, whose inner walls are rough from ad- herent layers of the thrombus ; if there has been periphlebitis, and the portion of vein has suppurated, we cannot decide with absolute certainty that there has been a previous suppuration of the thrombus. 20.— P. 372. The severest cases are those where toward the middle or end of the second day great cyanosis and collapse come on rapidly ; then death usually occurs in a few hours. Such patients look like those in the algid stage of cholera, only in septicaemia vomiting and per- sistent diarrhoea are rare ; after getting along well perhaps for twenty-four hours after the operation, the patients seem as if poi- soned. In these cases (which may be accompanied by diphtheria) the secretion from the wound does not always smell disagreeably. It cannot be shown that the intoxicating matter in these cases is different from usual, or that the inflammatory alteration of tissues causes a remarkable amount of poisonous product. According to the above, the variety of symptoms in septicaemia is considerable ; but this proves nothing against the claim that the septic poison is always the same, for there is the same difference from cholera, carbuncle, diphtheria, and bites of serpents, in which cases we do not assume dif- ferent natures, but only differences of intensity and in the quantity of poison absorbed, and difference of resisting power in the patients. ADDITIONS FROM THE EIGHTH GERMAN EDITION. 747 21.— P. 373. Some surgeons prefer to say that a patient who has been wound- ed or operated on has died of severe typhous traumatic fever, instead of using the term " septhsemia " or " septichaemia." This is an in- correct expression even if it were practically true. " Typhous " is used in the old sense, like the rvtyoq of Hippocrates, for stupid ; later the term typhous was applied to fevers in which the patient was stupid; during the last twenty years well-characterized infectious diseases have been called " typhus." It is better to use the name thus, and not bring the term typhous into use again. Virchow uses "ichorrhaemia" in the same sense that I do septicaemia; l%^>9 means blood-water, lymph, serum of wounds ; the older surgeons occasion- ally apply the term to thin, bad pus. 22.— P. 386. The cause of this is said to be that the septic matter, once taken into the blood, acts as a ferment, and that a small quantity suffices to cause decomposition of the blood and all the juices. As already stated, I do not consider this haematozymotic action of septic poison as proved ; on the contrary, I think that it, like the poison of diph- theria, malignant pustule, etc., often acts for so long a time and so differently, even when taken up in small quantities, because the hu- man organism (as well as that of some animals) only sets it free very slowly, and because at the points where it is retained in the body it often excites new foci, where the poison forms anew (perhaps less intense). For instance, I think dogs can bear so much septic poi- son because they pass it off so rapidly by the bowels ; they thus es- cape even very severe putrid infection. The power of getting rid of absorbed infecting poison more or less rapidly may vary with the individual to some extent. The same view would hold in typhus, cholera, and the acute exanthemata. 23.— P. 430. The rapid absorption of old torpid infiltrations is sometimes very favorably affected, as are neuralgic pains in chronically inflamed parts, by warm or hot local mud-baths. In some parts of Hungary hot springs open into the mud of small streams ; in this natural hot mud, which is used in tubs, the diseased limbs are soaked once or twice daily ; similar baths are prepared artificially. The bog-baths at Franzenbad and Marienbad are about as efficacious; the bog, 748 APPENDIX. soaked with ferruginous water, is warmed and used as the mud-baths above described. We do not know whether the mineral salts con- tained in the bath have any effect ; they probably act only as large cataplasms. Compresses wet with thermal water of iodine-springs have also a good reputation as resorbents. Usually they soon induce cutaneous eruptions, and may also be considered as derivative reme- dies. Animal-baths are also very popular; in these the diseased limb is placed among the intestines of an animal just killed, and kept there till the dead body is cold ; a peculiar effect is claimed for the animal warmth, of which I have been unable to convince myself. Lastly, we must mention hot sand-baths, which were formerly very popular ; these probably have no advantage over moist warmth. 24— P. 473. In these earlier stages massage may be carefully tried. You will accomplish but little by these therapeutic efforts ; you will find that as long as adult patients, can tramp around on their diseased bones, they will do so ; when you tell the patient that it is not certain the disease will get well if he lies quiet a few weeks, but that it will last months or years under careful treatment, he will attend to his busi- ness as long as possible. If the existence of your patient's family depends on his daily work, his case is very hard. It is just as hard to keep children constantly quiet ; a grown person must watch them all day. This is impossible, not only among the poor, but in large families among those in moderate circumstances. It is very easy to say the child must lie still several months, except when it is care- fully taken into the fresh air in a wagon or laid in a shady part of the garden during fine weather ; but if this has to be done for years, it is very expensive, for it requires the whole time of a careful adult nurse. This daily, hourly care for securing the best hygienic and dietetic conditions to a child with chronic disease, requires unusual patience and intelligence. Sacrifices are much more readily made for expensive medicines, or going to watering-places, to get the trouble over quickly. In such cases we must consider the circum- stances, so as to secure the best thing possible ; we may order me- chanical supports to keep the weight of the body off the bones. I give you these hints, so that you may not be too much disappointed in your future practice. You will often see that many chronic dis- eases which are not incurable never are cured, on account of some social reason. ADDITIONS FROM THE EIGHTH GERMAN EDITION. 749 25.— P. 505. Among the local sj^mptoms I may add that for each joint certain muscles gradualty become permanently contracted ; usually it is the flexors ; in the hip-joint the adductors and rotators are also affected, and the joint is permanently held in such a position as to give lit- tle or no pain. If these pathological positions are caused by the muscular contraction alone, and have not continued too long, they may at once be overcome by anaesthesia. But after months or years atrophy begins in the fasciae, and afterward in the muscles, which even under anaesthetics can only be broken up by force. After long disuse the muscles are greatly atrophied by fatty degeneration and cicatricial contraction. The articular capsule too, which was much infiltrated and swollen, as well as the accessory ligaments, also con- tract on the side toward which the joint has been bent ; thus, in the case of the knee-joint this contraction would be greatest in the hol- low of the knee. Cases where the disease begins with a seropurulent effusion in the joint (catarrhal, blennorrhoeal synovitis) are rare. I have seen them chiefly in tuberculous patients. The symptoms are at first the same as in chronic dropsy of the joint, but the joint is painful and its function more impaired. Comparatively often ostitis and periostitis near a joint are the causes of synovitis ; one or other side of the condyles of the femur, tibia, or humerus, or the posterior surface of the olecranon, become painful ; the pain remains localized for some time at one point ; then there is a doughy oedema, and finally an abscess. Meantime the functions of the joint may remain unim- paired for months, till the suppuration (occasionally with acute in- flammatory symptoms) attacks the joints ; then the course above described begins. In some cases these abscesses always remain periarticular, and heal before the joint is opened ; this might cause periarticular cicatricial contraction, while the joint was perfectly healthy. Lastly, the bones may be primarily attacked by ostitis malacis- sans ; this occurs particularly in the carpus, tarsus, and caput femo- ris of feeble patients ; the joints may long remain unaffected, even if periosteal abscesses with great oedema and suppurating fistulae form. In primary diseases outside of the epiphyses muscular con- tractions are less apt to develop than in primary disease of the syno- vial membrane and primary subchondral ostitis. 750 APPENDIX. 26.— P. 515. As yet I have no experience of the value of massage in the com- mencement of tumor albus ; it should be used with great care. I cannot help thinking that massage used too strongly in these cases might induce suppuration where there was any tendency to it ; so I would only recommend this treatment in torpid cases. 27.— P. 515. When the means of the patient admit, and there is a good dresser at hand, these bandages may be replaced by light splints, which do not require the joint to be kept quiet, but free it from the weight of the body as much as possible. In this direction mechanical surgery has made great advances ; by its aid, even in diseases of the lower extremities, many patients may be enabled to move about. 28.— P. 516. There is no doubt that in most cases of commencing and pro- gressing diseases of the joints traction is more efficacious than plas- ter bandages ; hence, in my clinic you will see it used more fre- quently ; but in private practice you will not persuade all patients to go to bed, and moreover the method requires such careful watch- ing from the surgeon as to interfere with its employment. Taylor, an ingenious American surgeon, has constructed splints for the lower extremity by which traction may be so applied as to free the joint from pressure and enable the patient to go about. These splints often act excellently, but they are difficult to make, and their use requires certain experience on the part of the surgeon. All of these mechanical aids — plaster dressings, supports, traction, Taylor's splint, etc. — require continued supervision to prevent injury from pressure and friction and from displacement of the apparatus. In the case of children great patience and perseverance are needed in judging whether the extension is enough or too great, to accustom them to the inconvenience of the apparatus, to quiet the anxiety of the par- ents when the child cries, and by friendly talk or sober, earnest ef- forts to make the children obedient and prevent their loosening the apparatus. This treatment can rarely be thoroughly carried out in private practice ; hence, treatment in hospitals or orthopedic institu- tions cannot be too strongly urged, at least until the chief dangers from deformity are passed. ADDITIONS FROM THE EIGHTH GERMAN EDITION. 751 29.— P. 523. Less attempt is made than formerly to obtain movable false joints after resection ; but more frequently we seek by partial re- moval of the bones chiefly diseased under Lister's method, and with the least possible suppuration, to cause anchylosis of the joint. 30.— P. 523. Unfortunately, return of the disease is not rare, even in joints which had been healed by anchylosis for years. Persons who have suffered from the above forms of chronic articular inflammation rarely attain old age. You will find few persons above forty or fifty years old with anchylosis from tumor albus. This seems another proof that these diseases are associated with some constitutional taint, difficult as it is in all cases to prove this, and to demonstrate it to those who are inclined to explain all diatheses and dyscrasise as vague theories of old physicians. 31.— P. 524. Tedious and painful as they are to the patient, they are not as- sociated with severe constitutional affections, such as tuberculous and lardaceous diseases ; hence they are rarely fatal, and are less dis- eases of youth than of mature age. 32.— P. 577. Careful examinations of veins by Soboroffh&ve shown that their walls are in very different conditions ; he examined especially the saphenous vein and its branches ; he found that normally in differ- ent persons its layers varied essentially, and that even adjacent parts of the same vein were not exactly alike. This is very interest- ing, for it explains why the occurrence of varices is so unequally in- duced by the same cause, and is due to purely individual circum- stances. Among varicose veins we may distinguish those with thin and those with thick walls. The enlargement of the muscular fila- ments and the lack of change in the endothelium are common to all. The variation in the diameter of the walls of the veins is chiefly due to thickening of the adventitia, whose vessels also increase, and of the cement which unites the muscular filaments; slightly also to thickening of the intima ; but sclerosis of the latter, as in arterial sclerosis, is very rare. Hence, under increased pressure the anatomi- cal conditions in the walls of veins are the same as in the urinary 152 APPENDIX, bladder and heart under similar circumstances. At first, in conse- quence of increased functional demands, the muscular filaments seem to grow ; if then nutrition is increased by increase of the vasa vaso- rum, the connective tissue, especially the adventitia, is decidedly in- creased ; if the nutrition be not increased, there is atrophy and total relaxation. 33.— P. 651. The following forms of sarcoma are of developed connective tis- sue, whose form depends greatly on the vessels : (g.) The (infiltrated and superficial) villous sarcoma, pearl-tu- mors, and psammona. As is well known, the serous membranes Fig. 139 a. From a villous sarcoma (cancroid of Arndt) of the pia mater, a, Commencing cell-infiltration in the capillary walls ; 6, clubbed proliferations growing: from the walls of the vessels ; c, the same covered with a thick layer of endothelium ; d, endothelial cells of the highest development, not to be distinguished from epithelial cells ; e, conglomeration of these cells into a spherical shape. Endothelial pearls. Magnified 400. ADDITIONS FROM THE EIGHTH GERMAN EDITION. 753 have the peculiarity in some pathological processes of forming ragged proliferations, whose basis is connective tissue and ultimately ves- sels, and whose covering consists of multiplied and enlarged endo- thelial cells. Well-developed shreds of synovial membrane in arthri- tis deformans, shreddy proliferations of the pericardium and endo- cardium on the valves, the plexus choroidei, and the Pacchionian granulations of the cerebral membranes, are the types of this neo- plasia. The tumors which to a certain extent may be regarded as the highest stages of development of this variety are only found in the membranes of the brain or the nerve-sheaths directly proceeding from it ; some of these neoplasias have a villous character, at least exteriorly ; others form compact masses, the dendritic tissues grow- ing through each other. These tumors form thus : A circumscribed cellular infiltration (a, Fig. 139 a) begins in the adventitious sheath of the vessel, which gives rise to clubbed, shreddy outgrowths, which soon become hya- line or filamentary connective tissue, and then develop a cavity in them, which gradually unites with the caliber of the vessel (b). Part of the cells assume epithelial forms and envelop the above club- shaped neoplasias (c). Between these cell-masses we find spheres of flat compressed cells (e), which in part become dry and under some conditions even calcareous. Whether the pearl-tumors ( Virchow) starting from the cerebral membranes, which are composed of pearly non-vascular nodules from the size of a millet-seed to a pea, are com- posed of such endothelial spheres, or are true epithelial formations, I shall not attempt to decide, as I have made no personal observa- tions, and there has been nothing published on this point recently. According to Virchow 's investigations, the pearls of the intracranial tumors are composed of connective-tissue cells ; hence they should be classed with sarcomata. Thymus pearls are the physiological examples of this form, which from their non-vascularity also have an analogy to tubercle. Another tumor described by Virchow and renamed belongs here, the psammona. This also has only been observed in the brain or in the orbit, and is related to the villous and to plexiform sarcoma, which we shall soon describe. This variety of tumor is characterized by the occurrence of calcareous spheres, having the form of the con- crements which are found in the pineal gland, and are there known as brain-sand (Trcra/x/zoc, sand). Like the thymus pearls, these are mostly connected with the vessels, and are probably mostly calcified endothelial pearls; but Virchow says that direct calcification of connective tissue may lead to the same forms. (h.) Plexiform (cancroid, adenoid) sarcoma. This form of sar- 48 754 Psammona, after Virchow. Magnified about 200. coma also is chiefly found in the orbit and brain, but sometimes oc- curs in the parotid gland. It can only be distinguished by very careful examination from some forms of carcinoma to be hereafter described. Plexiform cylinders, clubs, and spheres of small cells spread out in the connective tissue, separating its bundles and filling all the interspaces between them, in doing which they naturally push into the lymphatic vessels and perivascular lymphatic spaces. It cannot always be determined whether the cells first increasing are wandering cells, connective-tissue cells, or cells from the walls of the vessels, endothelium, or perithelium ; perhaps they all participate at the same time or after one another. The cells first proliferated are as a rule small, round, or irregu- larly polygonal ; gradually the following often complicated meta- morphoses occur in these cell-cylinders: Vessels grow into them, the middle part of the cells around the vessels becomes hyaline or filamentary connective tissue, the outer cells form a covering for the vessel and the central neoplastic connective-tissue filaments. So these formations have a sort of villous shape, which has grown into the tissue (interstitial papillary proliferations, interstitial papillary myxoma^Rindfleisch). At the same time the enveloping cells assume ADDITIONS FROM THE EIGHTH GERMAN EDITION. Fig. 139 c. 755 a , From a cerebral tumor, after Arnold, b, From a cerebral tumor, after Bindjleiscli. Magnified 300-400. such exquisite epithelial forms and positions that they may very readily be mistaken for sections of glands, especially when very slightly magnified (#, Fig. 139 c). Very peculiar forms occur when some of the cells in the primary cell-cylinders, by transformation of their protoplasm, become hyaline connective tissue («, a, a, Fig. 139 d). Then connected, dendritic, cactus-like formations enveloped in cells (but capable of being freed Fig. 139 d. Commencing hyaline metamorphoses in the early stages of a plexiform sarcoma. Commencement of the formation of cylindroma. After Sattler. Magni tied 500. 756 APPENDIX. from them) result ; vessels may grow into them, if the neoplasiae did not start from the vessels or grow around them. These peculiar hyaline clubs and cylinders were formerly regarded as lymphatic vessels. I recognized this error early, and took them for hyaline connective tissue, and from the hyaline cylinders called the tumor " cylindroma." But their commencement remained obscure ; the cylinders, composed wholly or chiefly of cells, I took for glandular Fig. 139 e. From a cylindroma (plexiform sarcoma with hyaline vegetations) of the orbit. Magnified 300. formations ; hence the mode of development of these new forma- tions remained doubtful for myself and some other observers, who had the opportunity of examining such tumors. Later I wavered a good deal over the significance of these things and their genetic combinations. Sattler's investigations first threw a clear light on the subject. The explanation just given seems to me the more probable, as it gives the key for explaining many varieties of these tumors. 34.— P. 664. Quite lately the investigations of Bizzozero and Neumann have shown an intimate relation between leucocythemia and disease of medulla of the bones, where according to the views of these ob- servers the transformation of colorless into red blood-cells should normally take place; so that leucocythemia would be due to this transformation being prevented from any cause. ADDITIONS FROM THE EIGHTH GERMAN EDITION. 757 35.— P. 664. A. von Winiwater in a recent work has drawn a very sharp boun- dary between malignant, rapidly-growing lymphomata and primary medullary sarcomata in the lymphatic glands (lymphosarcomata). The former are said always to come in several lymphatic glands of a part (especially of the neck) at once, long continue movable, but finally unite into one mass ; later other groups of lymphatic glands are attacked, and lastly internal organs. Two varieties may be dis- tinguished, one softer and grayish-red on section, the other firmer, fibrous, and more white on section ; the latter runs the more rapid course; both forms of malignant lymphoma are always fatal. Lymphosarcomata are either round-celled or spindle-celled; they come first in a gland ; the surrounding tissue is gradually affected, so that the tumor soon becomes immovable ; metastases to the lungs and spleen are common. I regard these distinctions as generally correct and grounded on careful observation, but believe that com- binations of the two forms are not rare. 36.— P. 674. By a choice of cases, the results of my thyroid operations have continuously improved. XUcke, Stork, and Schwalbe praise paren- chymatous injections of tincture of iodine or alcohol; this is said to cause a considerable or even total shrinkage of the struma. In the first cases where I used these parenchymatous injections of tincture of iodine, they had no effect; one case where I injected alcohol proved fatal from suppuration of the goitre and septicaemia. Lately in some cases I have obtained considerable diminution of the goitre by persistent injection of iodine; twice a week I inject one gramme of pure tincture of iodine; this must be continued several months. Under this treatment some patients emaciated greatly, so that I would not recommend it in feeble or tuberculous patients. Since the above-mentioned unfortunate case I have not tried alcohol injec- tions. Stork also has informed me that alcohol injections sometimes excite considerable inflammatory reaction, while after injections of iodine there is merely a temporary swelling and pain ; it is prudent at first to inject a third, then a half syringe full, to test the individ- ual susceptibility of the patient. 37.— P. 683. This view also finds supporters among the new school, who either do not recognize the typical formation of the tissue from the germ- 758 APPENDIX. layers, or else do not acknowledge its significance for the pathologi- cal neoplasias. Since this question was first earnestly discussed it has come up repeatedly, not only in the same generations, but to the same person. I cannot here repeat all that I have said about the origin and increase of true epithelia ; I will merely add that the car- cinomatous and epithelial forms found in primary cancer are also invariably found in the infecting tumors in the lymphatic glands. This seems to speak strongly in favor of the traveling of cellular elements, for it is scarcely probable that the fluid from a columnar epithelial cancer should influence the cells in the lymphatic glands to produce cylindrical epithelium. 38.— P. 684. From the above peculiarities even in the most difficult cases, we may always find the genetic differences between sarcoma and carci- noma. The first commencements of sarcoma and carcinoma are often scarcely distinguishable (compare Fig. 139 B with 162 and 163) ; both cases are very glandular in formation. But things change after a time ; the cell-cylinders of the sarcoma have either started from vessels, or vessels soon grow in them ; while this never happens in carcinoma, but the cylinders, even when quite large, remain without vessels, or else a cavity forms in them as in the development of glands (compare Fig. 139 b with 169). I dare not enter further into the general histological description of these tumors, and hope you will be able to recognize them. 39.— P. 685. When speaking of sarcoma I said something about the difference of its course from that of carcinoma. I here repeat again that the latter always first affects the adjacent lymphatic glands ; often the infection does not extend beyond them ; in other cases there may be metastatic tumors in internal organs or the bones. The small epi- thelial germs find the most favorable soil for their development in the lymphatic glands. The rapidity of the course varies exceeding- ly ; this we shall consider more closely when treating of the topogra- phy of carcinoma. In most cases no cause for carcinoma is discovered ; sometimes it has been preceded by injury or ulceration. My observation does not confirm what we hear and read about cancerous cachexia and the peculiar appearance of the patient. A person with cancer finally becomes marasmic, just like any one else who has severe disturbance ADDITIONS FROM THE EIGHTH GERMAN EDITION. 759 of the function of some important organ, and who absorbs particles of decomposing matter ; he becomes anaemic from haemorrhages, dis- turbance of digestion, and lack of nutrition ; then he emaciates rapid- ly and acquires the waxy, brownish hue (which in some complexions is a brownish green). But I have never been able to discover any- thing peculiar in these cases. There is no proof that such patients giye off any infecting substance, as is sometimes believed. REGISTER OF NAMES. PAGE Abernethy, John (f 1831, ia London) 475 Abulcasem(f 1106) 7 Aeby (professor of anatomy in Bern) 57 jEsculapius 4 Albert (professor of surgery, Innspruck) 361 Alexander of Tralles (525-605) 6 Alexandrian school 6 Anel, Dominique (surgeon in Turin, beginning of eighteenth century) 591 Antyllus (third century) 6, 592, 593 Amabile (professor in Naples) 97 Arndt (teacher in Greifswald) 649 Arnold, J. (professor of pathological anatomy at Heidelberg) . 64, 66, 67, 116, 317, 598 Asclepiades 4 Aselli (1581-1626) , 10 Auerbach (teacher in Breslau) 57 Avenzoar (1126) 7 Avicenna (980-1037) 7 Bardeleben (professor of surgery in Berlin) 107 Barensprung, von (1822-1864) 89 Barton, Rhea (Philadelphia) 232, 556 Bartscher (physician in Westphalia) 101 Barwell (London surgeon) 575 Baum (professor of surgery in Gottingen) 37, 172, 665 Baynton (English physician) 441 Beck 263 Becker, Otto (professor of ophthalmology in Heidelberg) 710 Bell, Benjamin (1749-1806) 11, 137 Bellocq, Jean (1732-1807) 35 Bergmann (professor of surgery in Dorpat) 361, 369, 742 Bernard, Claude (professor of physiology in Paris, f 1878) 56 Bernhardt, M. (physician in Berlin) 91 Biermer (professor of the medical clinic in Zurich) 385 Bilguer, John Ulrich (1720-1796) 12 Bizzozero (professor of pathological anatomy in Padua) 756 Boinet (surgeon in Paris) 527 REGISTER OF NAMES. 761 PAGE Bollinger (of Munich) 398 Bonnet (surgeon in Lyons, f 1863) 13, 238, 311, 403 Bouvier (surgeon in Paris) 552 Boyer, Baron (1747-1833) 12 Branca (fifteenth century) 8 Brasdor (1721-1799) 591 Braunschweig, Hieronymus (born 1430) 10 Breschet, G. (j 1845) 582 Breslau (1829-1867) 386 Broca (professor of surgery in Paris) 591 Brodie, Sir Benjamin (1783-1863) 13, 545 Bromfield, William (1712-1792) 27 Brown-Sequard (physician in Paris) 118 Briicke, E. (professor of physiology in Vienna) 143, 592, 745 Bruns, von (professor of surgery in Tubingen) 33, 205, 735 Brunschweig (born 1430) 10 Bubnoff (physician in Russia) 125, 358 Buck, Gurdon (New York) 206, 592 Buhl (professor of pathological anatomy in Munich) 288, 399, 422 Burow (professor of surgery in Konigsberg) 101 Celsius 89 Celsus, Aulus Cornelius (25 b. c. to 45 a. d.) 56 Chassaignac (surgeon in Paris) 155, 176, 475, 735 Chauliac, Guy de 735 Cheselden, William (1688-1793) 11 Chopart, Francois (1743-1795). 523 Ciniselli 592 Civiale (1792-1867) 13 Cohuheim (professor of pathological anatomy in Kiel). . 61, 196, 201, 317, 323, 404, 508, 576, 740, 745 Cooper, Sir Astley (1768-1841) 12, 53, 136, 681 Coote 591 Cruveilhier (professor of pathological anatomy in Paris) 352, 354, 543, 578 Czerny (professor of surgery in Freiburg) 97 Dalton, J. C, Jr. (New York) 599 Davaine (professor in Paris) 370, 398 Delpech (1772-1832) 12, 564 Demarquay 264 Desault, Pierre (1744-1795) 11 Dieffenbach, Johann Friedrich (1795-1847) 12, 37, 39, 45, 112, 134, 229, 402, 444, 529, 552, 631 Dittle (professor of surgery in Vienna) 131, 735 Dolschenkow (Russian surgeon) 343 Dorsey (Philadelphia, 1783-1818) 137 Dubois-Reymond (professor of physiology in Berlin) 55 Duchenne (de Boulogne) (physician in Paris) 574 Dupuytren, Baron (1778-1835) 12, 192, 332, 572 762 • REGISTER OF NAMES. PAGE Ebert (professor of diseases of children in Berlin) 343, 606 Eberth (professor of pathological anatomy in Zurich) 57 Ehrlich (of Vienna) , 349 Eichhorst (of Konigsberg) 116 Eschricht (of Copenhagen) 559 Esmarch, Friedrich (professor of surgery in Kiel) 179, 393, 430, 474, 517, 545, 546, 725, 739 Eustachio (f 1579) 10 Fabry von Hilden (1560-1634) 10, 37 Falopia (1490-1563) 10 Fick, Adolph (professor of physiology in Wiirzburg) 390 Fischer (professor of surgery in Breslau) 341, 369 Flourens (1791-1867) 490 Fook, Carl (1828-1863) 341, 544, 545 Foliin (1823-1867) 13, 451 Fox, Wilson (physician in London) 423 Frey (professor of zoology in Zurich) . 664 Frisch (professor of anatomy, Vienna) 343 Froriep, Robert (1804-1861) 119, 120 Galenus, Claudius (131-201) 6 Gersdorf, von, Hans (1520) 10 Goll (physician in Zurich) 388 Golubew (Russian physician) 55 Graefe, von, Carl Ferd. (1787-1840) 12, 40 Graefe, von, Albrecht (professor of ophthalmology in Berlin) 393 Gross, S. W. (of Philadelphia) 471 Guido de Cauliaco (fourteenth century). . .. 8 Gurlt (professor of surgery in Berlin) 193 Gussenbauer (professor of surgery in Liege) 65, 114 Giiterbock (of Berlin) 65 Halford (of Australia) 394 Haller, von, Albrecht (1708-1777) 12 Harvey, William (1578-1658) 10 Heine, Bernhard (instrument-maker and honorary professor of surgery in Wiirz- burg, contemporary with Cajetan von Textor) , 490 Heis, C 344, 599 Heister, Lorenz (1683-1758) 12, 680 Heitzmann (of New York) 419 Henke (of Tubingen) 563 Henle (professor of anatomy in Gottingen) 56, 57, 548, 549 Hennen, John (f 1828) 255 Hering (professor of physiology at the Josephs Academy, Vienna) 58 Hildanus, Fabricius 10 Hiller (of Berlin) 370 Hippocrates (460-377 b. c.) 4 Hjelt (physician in Sweden) 115 Hood, Wharton P. (of England) 555 REGISTER OF NAMES. . 753 PAGE Howard, B. (of New York) 98 Howship (English surgeon) 454 Hueter (professor of surgery in Greifswald). .40, 240, 369, 382, 403, 553, 559, 563, 564 Hufschmidt (physician in Silesia) 91 Hunter (1728-1793) 11, 18, 126, 591, 593 Hutchinson (surgeon in London) 692 Jackson (physician in Boston) 13 Jacobson (professor in Konigsberg) 91 Jaffray 737 Jobert (de Lamballe) (1799-1863)... 13 Jochniann (f physician in Prussia) 171 Kern, von, Yincens (1760-1829) 12 Kilian (of Prague) 459 Klebs (professor of pathological anatomy in Bern) 423, 613, 682 Kocher (professor of surgery in Bern) 127 Kochmann (of Strasburg) 743 Kolbe (of Leipzig) 181 Kolliker (professor of anatomy in Wiirzburg) 599 Koster (teacher of pathological anatomy in Wiirzburg) 507, 687 Krause (professor in Hanover) 129 Kiihne (professor of physiology in Amsterdam) 472 Kundrat (professor in Gratz) 322, 419 Lambl (professor in Kharkov) 693 Lanfranchi (f 1300) 8 Langenbeck, Conrad Martin (1776-1850) 12, 15, 129, 131, 230, 232, 262 Langenbeck, von, Bernhard (professor of surgery in Berlin). . 393, 500, 517, 552, 556, 572, 592, 737 Langhaus (professor of pathological anatomy in Bern) 418 Larrey, Jean Dominique (1766-1843) 12, 223, 255 Laudien (physician in Konigsberg) 91 Lawrence, Sir William (1783-1867) IS Leber (Gottingen) 343 Lebert (professor of the medical clinic in Breslau) 423, 647 Leroy d'Etiolles (1798-1861) 13 Letheby (of England) 400 Leube (Erlangen) 398 Leyden (professor of the medical clinic in Konigsberg) 90, 390 Liebermeister (professor of the medical clinic in Basel) 90> 385 Liebreich (professor of medicine, Berlin) -1 Lincoln, R. (of New York) 592 Linhart, von (professor of surgery in Wiirzburg) 682, 736 Lister (professor of surgery in Glasgow)... 101, 102, 105, 179, 180, 475, 731, 751 Livingstone (African explorer) 400 Lorinsen (of Yienna) 663 Losch (physician in St. Petersburg) °° Lotze (professor of philosophy and medicine in Gottingen) 54, 740 764 REGISTER OF NAMES. Lowdham (1679) 735 Liicke (professor of surgery in Bern) 575, 663, 665, 757 Lukomsky (army surgeon in Russia) 349 Luschka, von (professor of anatomy in Tubingen) 675 Malgaigne (1806-1865) 13, 242, 247, 590 Maslowsky (professor in St. Petersburg) . 114 Matthysen (army surgeon in Holland) 204 Meckel von Hemsbach (1821-1856) 472, 605 Menel (regimental surgeon in Saxony at the beginning of this century) 246 Menzel (of Trieste) 97, 423 Meyers, H. (professor of anatomy, Zurich) 561 Meynert (teacher in Vienna) 388 Middeldorpf (professor of surgery in Breslau, 1824-1868) 13, 128, 37, 624 Minnich (of Venice) 97, 107, 180 Mondino de Luzzi (fourteenth century) 8 Monro, Alexander (1696-1767) 11 Morant (of France) 501 Moreau (1782) 736 Morton (dentist in Boston) 13 Mott, Valentine (1785-1865) 13 Miiller, Johannes (1801-1858) 531, 600, 617 Miiller, Max (physician in Cologne) 208 Miiller, W. (professor of pathological anatomy in Jena) 398, 664 Nassiloff (of St. Petersburg) 343 Nestorians 7 Neudorfer (army surgeon in Vienna) 40 Neumann (of Konigsberg) 116, 743, 756 Niemeyer, von, Felix (professor of medical clinic in Tubingen) 418, 423 Oilier (physician in Lyons) 490 Oribasius (326-403) 6 Orth (Berlin) 343, 348 Panum (professor of physiology in Copenhagen) 39, 40, 360 Paquelin 740 Paracelsus, Bombastus Theophrastus (1493-1554) 10 Pare, Ambroise (1517-1590) 11, 27, 261 Park (1762) 736 Pasteur (professor of chemistry in Paris) 102, 105 Paulus ab ^Egina (660) 6 Percy, Pierre Francois (1754-1825) 11 Petit, Jean Louis (1674-1760) 11, 32 P6trequin (surgeon in Lyons) 591 Pfleger 345 Pfolsprundt (middle of the fifteenth century) 10 Piorry (professor of medicine in Paris) 378 Pirogoff, Nicolaus (professor of surgery in Russia) 204, 255, 259, 475, 523 Pitha, von (professor of surgery at the Josephinum in Vienna) 341 REGISTER OF NAMES. 7 6 ; PAGE Ploucquet (1744-1814) 735 Pollender 398 Polli (professor in Padua) 180, 385 Porta (professor of surgery in Pavia) 127, 128, 135 Pott, Percival (171S-1788) 11, 176, 465 Pravaz (f physician in Lyons) 591 Purmann, Gottfried (about 1679) 11 Raraton (middle of eighteenth century) 735 Raynaud (French physician) 333 Recklinghausen, von (professor .of pathological anatomy in Wiirzburg). . .58, 61, 62, 75, 125, 240, 358 Redfern (English physician) 61 Reverdin (of Geneva) 69, 72, 97, 608 Reichert (professor of anatomy in Berlin) 599 Remak, Robert (f 1865) 288, 574, 599 Rhazes (850-932) 7 Richardson (physician in London) 20 Richter, Aug. Gottlieb (1742-1811) 12 Ricord (surgeon in Paris) 579 Riedel (Gottingen) 741 Rindfleisch, Eduard (professor of pathological anatomy in Bonn) 59, 108, 288, 418, 423, 459, 636, 641, 670, 754 Ris (physician in Zurich) 207 Robin (professor of anatomy in Paris) 659 Rokitansky (professor of pathological anatomy in Vienna) 66, 119, 38S, 616 Rose, E. (professor of surgery in Zurich) 389 Rosenberg (Wiirzburg) 740 Roser (professor of surgery in Marburg) 305 Roux (1780-1854) 13 Rush 434 Rust, John Nepomuk (1775-1840) 12, 510 Salernian school 7 Samuel (Konigsberg) 63, 317, 320, 741, 742 Sattler "Hi Scarpa (1748-1832) 11 Schiff (professor of physiology in Florence) 56, 116, 7 10 Schmidt, Alexander (professor in Dorpat) 65, 111 Schneider (Saxon army surgeon, beginning of this century) 246 Schneider (physician in Konigsberg) 90 Schonlein, Lucas (1793-1864) 616 Schuh, Franz (1804-1866) 13, 654, 707 Schulze, Max (professor of anatomy in Bonn) 75 Schupple (Tubingen) 418 Schwalbe (of Weinheim) ?57 Schwann (professor of physics in Liege) 117, 598 Scoutetten (professor in Paris, 1830) ^36 Scultet (1595-1645) 204 Senator (physician in Berlin) 90 766 REGISTER OF NAMES. PAGE Seutin, Baron (1793-1862) 13, 205, 208, 222 Siebold, von, Carl Caspar (1736-1807) 12 Silvestri, Grandesso 739 Simpson, Sir James Y. (professor of obstetrics in Edinburgh) 13, 33 Sims (of New York) 35 Skutsch (physician in Silesia) 194 Smith, Nathan (Baltimore) 207 Sprengel (1766-1833) 736 Stanley (1791-1862) 13 Stein, Alex, (of New York) 98 Steudener (teacher of pathological anatomy in Halle) 288 Stork (professor in Vienna) 757 Strieker, Salomon (professor of general pathology in Vienna). . 58, 61, 62, 361, 370, 408 Stromeyer (formerly professor of surgery in Freiburg, Munich, Kiel, staff-physician in Hanover) 134, 164, 255, 315, 382, 545 Susrutas (first century ?) 4 Sydenham (1624-1689) 426 Syme (professor of surgery in Edinburgh) 593 Szymanowsky (professor of surgery in Kiev, 1868) 205 Taylor (of New York) 750 Textor, von, Cajetan (1782-1860) 12, 385 Theden, Chr. Ant. (1714-1797) 12, 34 Thiersch (professor of surgery in Leipzig) 65, 67, 97, 107, 124, 322, 610, 689, 695 Traube (professor of the medical clinic in Berlin) 89, 90, 171 Troja, Michele (1747-1827) 490 Trotula (twelfth century) 7 Tschausoff (Russian physician) 126 Valsalva (1666-1723) 590 Van Heke 384 Vanzetti (professor of surgery in Padua) 590 Velpeau (1795-1867) 13, 527, 707 Verduin (1696) 735 Vermale (French surgeon, middle of last century) 735 Verneuil (professor of surgery in Paris) 623, 670 Vesalius, Andreas (1513-1564) 10, 11 Vezin (of Westphalia) 101 Vidal (de Cassis) (end of the last century) ' 579 Villeuain (physician in Paris) 423 Virchow (professor of pathological anatomy in Berlin).. 51, 53, 57, 59, 61, 80, 110, 197, 201, 354, 360, 402, 408, 454, 497, 596, 602, 610, 650, 674, 753 Volkmann, Rich, (professor of surgery in Halle). .107, 178, 238, 288, 310, 454, 458, 468, 503, 533, 549, 557, 565, 575 Wagner, A. (professor of surgery in Konigsberg) 231, 490 Wagner, E. (professor in Leipzig) 428 Waldenberg (teacher of medicine in Berlin) 423 REGISTER OF NAMES. 767 PAGE Waldeyer (professor of pathological anatomy in Breslau). . . 599, 613, 615, 649, 682 Waller, Aug. (English surgeon) 61 Walther, von, Philipp (1782-1849) 12 Wardrop (f English surgeon) 591 Weber, Otto (1827-1867).. 13, 90, 91, 113, 121, 168, 360, 369, 472, 596, 609, 630 Wegner (teacher in Berlin) 228 Wells, Spencer (surgeon in London) 20, 384, 621 Wernher (professor of surgery in Giessen) 545, 706 Wertheim (physician in Vienna) 447 White (1769) 736 Winiwater, A. von (teacher in Vienna) 757 Wolff, J. (of Berlin) 200, 490 Wunderlich (professor of the medical clinic in Leipzig) 89 Wiirz, Felix (f 1567) 10 Wutzer (1789-1860) 13 Wyss, O. (professor of the polyclinic in Zurich) 423 Wywodzoff (physician in St. Petersburg) 85, 86 Zaleski (professor in Kharkov) 612 Zeis (f 1868) 441, 740 Zenker (professor of pathological anatomy in Erlangen) 678 Ziegler (of Wurzburg) 419 Ziemsen (professor of the medical clinic in Erlangen) 574 INDEX. Abdomen, contusion of, 156. Abiogenesis, 103. Abscess, 74, 149, 292 ; of bone, 464; cold, 405, 4T0 ; congestive, 40T, 466 ; of kidneys, 360 ; of liver, 360 ; metastatic, 360 ; periarticular, 511 ; sub- cutaneous puncture of, 475. Acetate of alumina, 180, 336. Aconite in pyaemia, 385. Acorn-coffee, 417. Acupressure, 33, 130. Acupuncture, 130, 229. Acute articular rheumatism, 313. Adenoma, 657, 669. Adeno-sarcoma, 657. Adhesive plaster, 42 ; in burns, 270 ; to favor ab- sorption, 295 ; in ulcers, 441. Advanced age as a cause of tumors, 610. Agur-Veda, 3. Air, entrance of. into veins, 23. Alveolar formation as a peculiarity of cancer, 681. Ambulances, 258. Amoeboid movements, 75. Amputation, 313, 720 ; for gangrene, 337 ; for py- aemia, 386 ; osteomyelitis, 306. Amyloid degeneration, 408, 472. Anaemia causing gangrene, 333. Anaesthesia, local, 20. Anaesthetics, 13. Anchylosis, 241, 546 ; cartilaginous, 549 ; extension of, '558 ; osseous, 557. Aneurism, 135, 580; dissecting, 137; of the ex- tremities, 588 ; popliteal, 589 ; spurious or trau- matic, 135 ; varicose, 138 ; cirsoid, by anasto- mosis, racemose, 581 ; cylindriform, fusiform, sacculated, 586. Aneurismal varix, 638. Angioma, 638 ; cavernous, 640. Anthrax, 283, 397. Antiseptics, 106, 336. Antrum Highmori, cysts of, 675 ; cancer, 707. Apoplexy, 144. Aqua Binelli, 37. Arnica, 150. Arterial thrombosis, 330. Artery, healing of wounds of, 134 ; hook, 27 ; liga- tion, 27 ; mediate ligation of, 28 ; percutaneous mediate ligation, 28 ; rupture of, in open frac- tures, 212 ; torsion of, 29; contusion, 162. Arthrite seche, 534. Arthritis, 315, 425; deformans, 534. Arthrocace, 510. Arthrocacologie, 510. Asklepiades, 4. Asphyxie locale. 831. Atheroma, 426, 584, 675. Bacteria, 102. Baker's leg, 562. Bandage, fenestrated, 222. Barbers and bathers, 9. Baths, 747. Beating experiment, 156. Bed-sore, 329. Belloc's sound, 35. " Black eye," 146. Bladder, cancer in, 694. Bleeding in delirium tremens, 392. Blenorrhcea, 287. Blisters, 431. Blood-clot, 119. Bloodless operations, 739. Blue pus, 341. Bone-corpuscles, 197 ; abscess of, 482 ; absorption of, 231 ; atrophy and hypertrophy, 461, 502 ; ex- ercise, 635; fracture of, 185; fissure of, 187; re- absorption of, 197 ; tubercles in, 456 ; regenera- tion, 478 ; setting, 555. Book of the Art of Life, 3. Brain-sand tumors, 649. Brisement force. 551. Bromfiel(Vs artery -hook, 27. Bullet-forceps, 262. Burns, 266, 566. Burnt sponge, 418. Bursa, dropsy of, 532. Cachexia, cancerous, 702. Cadaveric poison, 395. Calculi, vesical and renaL 426. Callus, 190, 450. Cancer, 680; atrophying, 700; of bladder, 694; of bone, 684 : cauliflower, 692 ; colloid, gelatinous. 685 ; en cuirasse, 707 ; epithelial, 685 ; of hand. 693; lenticular, 707; of skin, 692; villous, 694; stomach and duodenum, 709 ; lachrymal, saliva- ry, and prostate glands, 710 ; mammary, 696 ; thyroid gland and ovary, 711 ; of lip, 610 ; pap- illary, 685 ; transplantation of, 607, 694. Cancroid, 685. Canine madness, 400. Carbolic acid, 180. Carbuncle, 283, 397, 743. Carcinoma, 680. Carcinosis, 711. Caries, 454, 458. Cartilage-tumors, 627. Caseous degeneration, 407. Cataplasms, 177. Catarrh, 287. Catching cold, 278. Caustics for cancer, 432, 717. Cautery, actual, 36 ; iron, 432. Cavernous venous tumors, 640; lymphatic tu- mors, 644. Cells, wandering, 58. Cellular tissue, inflammation of, cellulitis, 295. Cephalhematoma, 146. Cerebri, compressio, contusio, 142. INDEX. 769 Chalky concrement, 408. Chancre, 427. Chemical ferments, 167. Chicken-breast, 497. Chilblains, 275. Chill, 377. Chinese silk, 44. Chiragra, 315, 426. Chloride of zinc, 445, 716. Chloroform, 13. Chlorosis, gangrene in, 333. Cholesteatoma, 675. Chondromata, (327. Choroiditis, metastatic, 176. Cicatricial islands, 268. Cicatrix, 72 ; deformities caused bv, 566 ; opening of, 112. Cicatrization, 72. Cinnabar method, 114, 126, 266. Circulation, collateral, 51. Cirrhosis, 418; mammae, 706. Cirsoid aneurism, 638. Clap, 289. Clavicle, fibromata on, 622. Cloaca, 484. Club-foot, 558. Coal-dust in lungs, 370. Coccobacteria, 103, 343, 369. Coccygei, tumores, 677. Cock's-comb-like vegetations. 618. Cod-liver oil, 445. Cohnheim, 6. Cold abscess communicating with diaphvses, 477; joint, 316. Cold-water bath, 172. Collateral circulation. 128. College of St.-Come, 9. Collodion, 42. Collonema, 650. Comedo, 674. Compression of arteries, 30 ; of brachial, 31 ; ca- rotid, 30 ; femoral, 32 ; subclavian, 31 ; of vari- cose veins, 580 ; of lymphoma, 665 ; as mode of treatment. 429. Concussion of nerves, 142. Condylomata, 446, 668. Congestion, 53. Connective-tissue corpuscles, 58 ; tumor, 618. Contusion by bullets, 256 ; of joints, 234 ; of nerves and vessels, 143 ; of soft parts 'without wounds, 141. Cooper, 12. Cordova school, 7. Cornea, wound of, 82. Counter-extension, 202. " opening,176. Coxitis, 565. Crepitation, 1S8, 244. Cretinism, 606. Croton-oil, 431. Croupous inflammation, 2S9. Curare, 394. Curvature of spine, 499, 561. Cutis pendula, 618. " acute inflammation of, 2S1. Cylindromata, 669, 756. Cyphosis, 561. Cyst, 148, 674 ; neoplastic, 676 ; of ovary, testicle, breast, 676; retention, secretion, 674; contain- ing foetus, blood, 677. Cysticercus cellulosa?, 678. Cystoma, 657, 674. Cysto-sarcoma, 659. Deafness from ergotism, 334. Decubitus, 329. Deformities from cicatrices, 566. Delirium nervosum, 392; potatorum, in open fracture, 222, 391. Derivatives, 430. Desmoid tumors, 619. 49 Deuteropathic, 606. Development of body, 559. Diabetes mellitus, carbuncle in, 2S6; cause of gangrene, 334. Diapedesis, 319. Diaphyses, disease of, £01. Diathesis (see Dyscrasia). DieffenbacJi's operation for false joint, 229. Digitalis, 885. Diphtheria, 289; of wounds, 324; traumatic, 166; urinary, 343. Dislocation, 242 ; of hip. jaw, shoulder, 249 ; ha- bitual, 249; complicated. 250; congenital, 251. Dissecting wounds, 394 ; tubercles, 606. Distortion, 235. Distractionsmethode, 516. "Doctor," 7. Dolores osteocopi, 450. Double joint, 497. Drainage-tubes, 101, 176. Dropsy of the joint, 524. Drunkard's mania, 891. Drunkenness, 387. Dynamometer, 247. Dyscrasia, diathesis, 412; cancerous, 615 ; scrofu- lous, 418 ; tuberculous, 418 ; tumor, 615. Dysmorphosteopalinklastes, 231. Ear, haemorrhage from, 5S3 ; rings, 112. Ecchondrosis ossificans, 632. Ecchymosis, ecchymoma. 145, 243. Echinococcus hominis, 678. Ecrasement, 155, 624. Eczema solare, 270 ; eczema of leg, 577. Electricity for contractions, 574. Electropuncture, 229. Elephantiasis, 405, 619. Embolhaemia, 380. Embolism, 353, 359, 5S6. Emetics, 350. Emplastrum cerussa?, 42. Empyema of joint, 310. Encephaloid, 652. Enchondroma, 530. Endocarditis causing gangrene, 883. Endothelium, 640. English disease, 495. Enroulement of varicose veins, 579. Epileptiform spasms, 134. Episiohaematoma, 146. Episiorrhagia, 146. Epithelial cancer. 6S5. "' pearls, 688. Epulis, 656. Erectile tumor, 638. Erethitic granulations, 109. Ergotin, 592. Ergotism, 334. Erysipelas, 166; ambulans, 345; bullosum, 346 ; capitis, 349 ; traumatic, 281, 344. Esmarck's wound-douche, 96. Ether, 18. Exanthemata, acute, 281. Excoriation, 145. Exfoliation, 215. Exostoses, 631. Extension, 202. Extirpation of bone, 479. Extravasations of blood, reabsorption of, 147; suppuration of, 148. False joint, 198, 226. Farcy, 396. Fatty tumors, 625. Febrile reaction, 169. Felon, 306. Female pupils, 7. Fenestrated bandages, 222. Fever, hectic, 409 ; secondary, 862 ; suppurative, 171; traumatic, 88, 171, 221, 741. 770 INDEX. Fibrine, 354. Fibroma, fibrous tumors, 148, 618; pigmented, 618. Figure, 9, 401. Fingers, chondromata of, 630. " tenotomy in, 571. Fire-arms first used, 254. Fire-mole, 645. Fistula, 407, 438. Flat-foot, 498. Fluctuation, 145. Fluxion, 53. Flying hospitals, 259. Fontanel, 432. Forced extension, 231. Formative cells, 596. Fracture-box, 207. Fractures of bones, 185 ; causes, 1S6 ; complicated, 210 ; gunshot, 254 ; open, 210 ; prognosis of, 211 ; of thigh, 212 ; of olecranon, patella, 227 ; oblique- ly united, 231 ; reduction of, 202 ; symptoms, 187; union, 208; varieties, 187. Fragilitas ossium, 186. Fragments of bone, reposition of, 202. Freckles, 618. Freezing, general, 274. Friction-sound, 532. Frost-bite, 271. Furunculosis, 282. Galvano-caustic, 37. 624. Ganglion, 528. Gangrene, 157, 326; hospital, 110 ; from compres- sion, 329; senile, 330; g. nosocomialis, 339. Gastric catarrh, 609. Gelenkmaus, 542. Generatio aequivoca, 103. Geneva convention, 260. Genu varum, 498 ; valgum, 561. Germ-layers, 599 ; tissue, 5J. Giant-cells, 418. Glanders, 396. Gliosarcoma, 646. Globules epidemiques, 68S. Glycerine, 181. Goitre, 605, 672. Gomarthrocace, 510. Gonorrhoea, 289, 315, 427. Gout, 425. Granular cells, 78. Granulations, 71 ; diseases of, 108 ; croup of, 110; erethitic, 109 ; fungous, 108. Granulation tissue, 74 ; g. stage of tumors, 596. Gravel, 426. Grog, 392. GrutzbeuteL, 675. Gummy tumors, 428. Gun shot- wounds, 254. Gutta-percha splints, 205. Gymnastics, 574. Haemarthron, 234. Haematodes, 638. Haematoidin, 147. Haematoma, 145. Haemato-thorax, pericardium, 146. Haemophilene, 24. Haemorrhage, 21 ; arterial, 22 ; capillary, 21 ; from contused wounds, 154; from gunshot-wounds, 24; haemostatic, 164; from pharynx, posterior nares, rectum, 24 ; parenchymatous, 24, 54 ; pulmonary, 422; secondary, 162; subcutaneous, 143 ; venous, 23. Haemorrhagic diathesis, haemophilen, 24, 164. Hasmorrhoids, 578. Haemostatics, 27. Hair in moles, 645. Hatisteric atrophy of bone, 459. Hare-lip suture, 46. Healing by first intention, 49 ; by first and second intention, 99. Heat, 518. Hectic, 409. Helkologie, 447. Herba jacea, 417. Hereditary influence, 412, 422, 577, 604. Hernia, mortification in strangulated, 329. Horny excrescences, 667. Hospital gangrene, 110, 166, 339, 355. Hospital, field, 259. Housemaid's knee, 532. Humoralists, 278 ; view of tetanus, 389. Hyalinose, 472. Hydrargyrosis, 428. Hydrarthrus, 524. Hydrate of chloral. 21. Hydrocele, 527, 644. Hydrophobia, 400. Hydrops articulorum, 308 ; genu acutis, 309 ; chronicus, 503. Hygroma praepatellaris, 532. Hyperaemia, 53. Hyperplasia, 404. Hypertrophy, 596 ; homeoplastic, heteroplastic, hyperplastic, 596. Hypersecretion, 405. Hypodermic injections, 21. Hystricismus, 668. Ice in inflammation. 175. Ichor, 380. Ichoraemia, 380. Ichthyosis, 668. Icterus from snake-bite, 394. Immersion, 172. Indifferent cells, 598. Infarctions, 359, 374. Infiltration, cellular or plastic, 59; cedematous,.59. Inflammation, traumatic, 49, 80 ; of contused wounds, 165; phlegmonous, 289; secondary, 164, 384 ; in tumors, 602 ; of wounds, 79 ; chronic, 403. Inflammatory new formation, 59. Infraction, 231 . Injections, subcutaneous, of iodine, 526, 679. Insolation, 270. Irrigation, 172. Isinglass-plaster, 41. Itch, 411. Ivory pegs used in pseudarthrosis, 229, 454. Jaundice (see Icterus). Joint mouse, 542. Joints, catarrhal inflammation of. 308 ; cold ab- scesses communicating with. 306; dropsy of, 524; inflammation of, 235, 308 ; gonorrhoea! in- flammation, 315; pyaemic, 316; metastatic. 316; puerperal. 316; flexed position of, 237; loose bodies in, 542 ; movements of. 547 ; open- ings of, 235; penetrating wounds of, 235; stiff, 548 ; scrofulous inflammation of, 504 ; tapping, 526; treatment of inflamed, 239. Knee-joint, inflammation of, 504. Knitting-needle as foreign body, 130. Knock-knee, 563. Laced-stocking, 580. Lactic acid, 197. Lacunar corrosions, 454. Lardaceous deposit, 408. Leontiasis, 619. Leucin, 75. Leucocythemia, 664. Ligaments, division of. 572. Ligation of arteries, 2S, 591 ; mediate, 28; of polypi, 624 ; of telangiectases, 643. Ligature, 26. Lightning-stroke, 271. INDEX. 771 Lime, 228. Line of demarcation, 157, 275, 328. Lipoma, 530, 625. Liquid-glass dressings, 205. Liquor ferri sesquichlorati, 37, 591. Lister's dressing, 101, 105, 179, 731. Locus minoris resistentiae, 278. Loxarthroses, 558. Lupus, 444. Luxation, 242 ; old, 251 ; inter partum acquisitae, 252. Lymphangioma cavernosum, 644. Lymphangitis, 166, 351. Lymphatic glands, disease of, 662. " vessels, inflammation of, 351. " diathesis, 414. Lymphatics in synovial membranes, 240. Lymphoma, 662. Lympho-sarcomata, 663, 757. Lyssa, 400. Macroglossia, 644. Maggot, 674. Maliasma, 396. Malignant carbuncle, 283. Malum senile coxse, 534. Mamma, cancer of, 695. Manipulation, 567. Manus vara, 560. Marasmic thrombus, 331. Massage, 429, 742, 750. Match-maker's poisoning, 489. Mediate ligation, 28. Medullary, 663. Melano-carcinomata, 685. Melanoma, melanosis, 608 ; benignant, 618. Meliceris, 675. Meningocele, 674. Mercury in syphilis, 428. Metastatic abscesses. 360; inflammations, 376; meningitis, 376 ; tumors, 607. Methyline, 20. Miasm, 279, 355. Micrococcus, 103. Miliary tubercles in bones, 464. Military surgeons, 254. Mineral waters, 427. Mitella, 207. Moist gangrene, 326. Moist warmth, 427. Moles, 618. Moluscum contagiosuin, 606 ; m. fibrosum, 618. Morbus Brightii, cause of gangrene, 334; with caries, 472. Mortification, 326. Morve, 396. Mother's marks, 642. Mouth and hoof disease, 399. Moxa, 432. Mucous bursa?, inflammation of, 297. " " fistuteof, 531. Mucous membranes, inflammation of, 405. Mucous tissue, 649. Mud baths, 747. Multiplying pulleys, 246. Mummification, 326. Mures articulares, 542. Muscles, inflammation of, 296 ; contraction of, 563; rupture of, 181 ; artificial, 575. Muscular contractions, 563. Myelitis spinalis, 388. Myeloid tumor, 656. Myoma, 637 ; tevicellulare, 620. Mvosin, 75. Myositis, 296. Myotomy, 568. Naevus. 638 ; vasculosus, 645. Nares, plugging, 34. Nasal mucous polypi, 670. Necrosis, 157, 303, 479; diagnosis from caries, 490 ; induced, 481 ; from phosphorus, 489. Needle-holder, 45. Needles, surgical, 43 ; as foreign bodies, 130. Nephritis metastatic, 377. Nerves, regeneration of, 117 ; compression of, 142. Neuromata, 117, 622, 637. Neuropaths, 278. Noma, 334. Nulltour, 46. Occlusion of wounds, 100. Ocular muscles, tenotomy of, 571. Odontoma, 632. (Edema, 19. (Esophagus, stricture of, 568. Oil of turpentine, 37. Oil poured in wounds, 261. Omarthrose, 510. Oncotomy, 296. Onkology, 602. Open fractures, 210 ; treatment of, 222. Open treatment of wounds, 100, 178, 224. Opium, 390. Organic beings, development of, prevented, 180. Orthopedy, 567. Osseous granulations, 215. Ossium sclerosis, 460 ; leontiasis, 460. Osteocopic pains, 450. Osteoid chondroma, 657. Osteoma, 631. Osteomalacia, 186, 495, 500. Osteomyelitis, 301. Osteophlebitis. 303. Osteophytes, 220, 449. Osteoplastic periostitis and ostitis, 449- Osteoporosis, 501. Osteosarcoma, 656. Osteotomy, 232, 463, 556. Ostitis, 241, 307, 448; caseous, 455; fungosa. 455; gummosa, 45S; interna, 458; rarefying, 464 ; vascular, 455. Ovary, adenomaof, 670 ; cysts of, 6S0; cancer, 711. Padua school, 7. Pain, 19, 409. Panaritium, 2S9, 298; periostale, 306. Pap-bags, 675. Papillary proliferations, €03 ; p. hypertrophy, 605. Papilloma, 666. Paquelin's cautery, 740. Paraglobulin, 75. Paralysis, 565. Paraphimosis, 329. Parasites, cystic, 678. Paronychia, 289. Pavia school, 7. Pearl tumors, 752. Pectus carinatum, 495. Pe?vis, chondroma of. 629. Penghawar Djamba, 739. Periadenitis, 353. Perilymphangitis, 357. Periosteum, 800, 480. Periostitis, 301, 448 ; osteoplastic, 200 ; suppura- tive, 221. Periphlebitis, 357. Peripsoitis, 563. Permanent extension, 206. Perniones, 275. Pes planus, 562 ; varus, 558. Peyer's glands, hypertrophy of, 666. Pharynx, chronic catarrh of, 665. Phlebitis, 166. 353. Phlebolithes, 578. Phlegmonous inflammation, 289. Phlogogenous, 93. Phosphorus, 228. Phosphorus-poisoning, 489. Pin in vesical calculus, 131. Pityriasis versicolor, 411. 772 INDEX. Plaster, 41 ; adhesive, 42 ; ichthyocolla, 48 ; splints, 203, 265. Plaster of Paris bandage, 203. Plastic operations, 740. Pleuritis, 376. Podagra, 315, 426. Pcedarthrocace, 465. Poisoned wounds, 393. Polypus, 603 ; aural, 670 ; cystic, 675 ; mucous, 670 ; nasal, 671; nasopharyngeal, 622; rectal, 671; uterine, 622. Porcupine-disease, 668. Position as a mode of treatment, 178. Posterior nares, plugging, 35. Pott's boss, 465, 561 ; knife, 176. Pourriture des hopitaux, 339. Pressure for cure of cicatrices, 568. Prostate, hypertrophy of, 637 ; cancer of, 669. Protagon, 75. Provisional dressing, 206. " callus, 192. Psammona, 649, 752. Pseudarthrosis, 198, 226. Pseudo-erysipelas, 289. Psoitis, 297, 563. Puerperal fever, 371, 386 ; inflammation of joints, 316. Pulse in inflammation, 88. Pulsionssystem, 384. Punctured wounds, 130 ; of arteries, 134 ; of cav- ities, 134 ; of nerves, 134 ; of veins, 139. Punk, 37. Purpura, 145. Purulent infection, pyaemia, 373. " infiltration, 292. Pus, 71, 291 ; injected into the blood, 92. " disease, 373. Pustula maligna, 284. Putrid fever, 170. " matter injected into the blood, 369. Pyaemia, 222, 316, 367, 373; in newly-born, 317; spontaneous, 383. Pyohaemia, 380. Pyrogenous, 92. Quinine, 385. Eachitic rose-garland, 497. Eachitis, 495. Eailroad injuries, 152. Eanula, 675. Eaphania, 334. Easpatorium, 494. Eeabsorption of dead bone, 231. Eectum, cancer of, 709. Eecurrence of tumors, 615. Eed blood-cells, escape of, through walls of ves- sels, 404. Eedness, 409. Eesection, 736; of fragments. 230; for anchylosis, 556; of ankle. 522; of elbow, 519; of hip, 519; of joints, 518; of knee, 520; partial, 516; of shoulder, 519 ; total, 251 ; of wrist, 521. Eesolvents, 430. Eest, 177, 429. Eheumatism, 309, 535; gonorrhoeal, 278, 313. Eheumatic gout, 537. Rheumatismus nodosus, 537. Ehigolene, 20. Eickets, 186. Euptures of muscles, 182. Salamanca school, 7. Salivary glands, adenoma of, 661, 710. Salt-water baths, 46, 664. Sand-bags, 207. Sarcoma, 645; alveolar, 650; gelatinous, 650; giant-celled, 648; granulation, glio-, 646 ; fas- ciculate, 652 ; mucous, 650 ; mammary, 657 ; melanotic, 651; ossification of, 652; pigmen- tary, 651 ; net-celled, 650 ; spindle-celled, 646. Sarcomatous papillomata, 693. Scalds, 266. Schneider- MeneF 8 apparatus, 246. Scirrhus, 603, 680; mammae, 695. Sclerosis ossium, 460. Scoliosis, 499, 561. Scorbutis, 427, 446. Scorpion, 394. Scrofula, 414, 662. Sebaceous glands, cysts of, 674. Secondary inflammation of suppurating wounds, 170. Secondary or suppurative fever, 170. Sepsin, 369. Septicaemia, 162, 170, 222, 368, 746. Septopyaemia, 382. Sequestrotomy, 493. Sequestrum, 220, 479. Serous sacs, hypersecretion of, 674. Seton, 229, 432. Shock, 156. Silk, 44. Siren, 559. Skin-grafting, 97. Slings, 207. Snake-bites, 394. Snuffles, 278. Sphacelus, 326. Spina ventosa, 465. Spleen, hypertrophy of, 663 ; in pyaemia, 361. Splints, plaster of Paris, 203 ; dextrine, white-of- egg, paste, 205 ; gutta-percha, 205 ; liquid-glass, 205; starch, 205. Spongy bones, inflammation of, 306. Sprain, 235. Spurred rye, secale cornutum, 333. Squirrhe pustuleux, 707. Starch-dressings, 205. Sterno-cleido-mastoid muscle, division of, 571. Stiff joints, 505. Stings of insects, 393. Stomach, cancer of, 709. 8trabismus, operation for. 571. Struma, 671; aneurysmatica, 673 ; cystica, 671. Stumps, conical, 732. Styptics, 36. Subcutaneous operations, 134, 232. Subluxation, 242. Sugar in urine, 286. Suggillations, 145. Sulphurets of the alkalies, 385. Sunburn, sunstroke, 270. Suppuration, 405 ; blue, 382. Suppurative fever, 373. Surgeon's knot, 28. Surgical needles, 42. Sutures, 42; of bone, 229; catgut, horsehair, 46 ; interrupted, 44 ; twisted, 46. Swedish movement-cure, 574. Swelling in inflammation, 409. Synovia, escape of, 236. Synovial hernia, 527 ; membrane, 507. Synovitis, 240 ; parenchymatous, 309 ; chronic serous, 503, 524. Syphilis, 427, 446. Syphiloma, 428. Tadpoles, regeneration of, 117. Tampon, 34. Tapping the joints, 526. Tarantula, 394. Tartar- emetic ointment, 431. Telangiectasis, 638. Temperature in disease, 89. Tendo Achillis, rupture of, 182. Tendons, affections of sheaths of, 527 ; luxations of, 252. Tenotomy, 568. Tetanus, trismus, 184, 887. INDEX. 773 TliederCs, dressing, 34. Thermometer in disease, 89. Thrombosis, 139, 320, 330, 353, 359. Thrombus, 119, 355. Thymus gland, hypertrophy of, 666. Thyroid gland, adenoma of, 671 ; cyst of, 672 ; cancer, 711 ; tumors of, 670. Tibia, fibromata on, 622. Tincture iodinii, 431. Tissu fibroplastique, 647 ; heteroadenique, 684. Tonsils, hypertrophy of, 665. ' Tourniquet, 32. Transfusion, 39. Transplantation of cancer-germs, 607, 694. Traumatic fever, 89, 170. " tetanus, 134. Trichinae, 678. Trismus in open fractures, 222, 387. Trocar, 130. Tuberculosis, 418. Tumor albus, 404, 504. Tumors, 595 ; benign, 604 ; cancerous, 604 ; carti- lage, 618 ; of brain, 603 ; colloid, 616 ; conta- giousness of, 608 ; fatty, 625 ; infectious, 612 ; malignant, metastatic, 607 ; multiple, 619 ; sec- ondary, 607 ; vascular, 638. Turning the foot, 235. Turpentine for haemorrhage, 37. Typhous diseases, 371. Tyrosin, 75. Ulcer, 434; atonic, 437; catarrhal, 436; callous, 440 ; erethitic, 436 ; fungous, 440 ; fistulous, sinuous, 442; lupous, 444; open, 444; phage- denic, 442 ; proliferating, 437 ; scorbutic, 446 ; scrofulous, 436 ; suppurating, 442 ; symptomat- ic, 443; syphilitic, 446; typhous, 436; varicose, 577. Ulceration, 827, 405. Urethral caruncles. 671 . Uterine lymphangitis, 351 ; cancer, 710. Vaccination of angioma, 643. Valsalva's treatment of aneurism, 590. Varices, 596, 751. Varicose ulcer, 544. Varix aneurysmaticus, 138, 578. Vascular tumors, 638. Vein-stones, 578, 640. Veins, varicose, 443 ; injection of ammonia into, 400 ; injured in open fractures, 212 ; wounds of, Venesection, 22, 139, 358. Ventilation, 384. Veratria, 385. Vesical cancer, 694. Vibices, 145. Villous cancer, 693. Vipera, 394. Vitelline spheres, 599. Wandering cells, 58, 822. Warts, 667. Water-bath, 174; canker, 324. White-of- egg, 205. "Wind of the ball," 256. Wire sutures, 44. Wound-douche, Mmarcli's, 96. Wounded persons, care of, 88. Wounds, contused, 152; croup of, 110; diph- theria of, 110; flap, 18; incised, 17; gunshot, 254 ; penetrating, 18 ; poisoned. 393 ; puncture, 130. MEDICAL WORKS PUBLISHED BY D. APPLETON & 00. Anstie on Neuralgia. 1 vol., 12mo Cloth, $2 50 Bartholow's Treatise on Therapeutics " 5 00 Barker on Puerperal Diseases. 1 vol « 5 00 Barker on Sea-Sickness. 1 vol., 16mo » 75 Barnes's Obstetric Operations. 1 vol., 8vo t; 4 50 Bellevue and Charity Hospital Reports. 1 vol., 8vo '• 4 00 Bennet's Winter and Spring- on the Mediterranean. 1 vol., 12mo " 3 50 Bennet on the Treatment of Pulmonary Consumption. 1vol., 8vo li 1 50 Billroth's General Surgical Pathology and Therapeutics. 1 vol., 8vo.... li 5 00 Buck's Contributions to Reparative Surgery. 1 vol., 8vo " 3 00 Bastian on the Common Forms of Paralysis from Brain Diseases " 1 75 Bulkley's (L. D.) Acne ; its Pathology, etc (Injrress.) Combe on the Management of Infancy. 1 vol., 12mo Cloth, 1 50 Carpenter's Mental Physiology " 3 00 Chauveau's Comparative Anatomy of the Domesticated Animals. Ed- ited by George Fleming, F.R. G. S., M. A. I. 1 vol., 8vo, with 450 Illustrations. ... " 6 00 Davis's (Henry G>.) Conservative Surgery " 3 00 Dickson on Medicine in Relation to the Mind " 3 50 Elliot's Obstetric Clinic. 1 vol., 8vo " 4 50 Ecker s Convolutions of the Brain " 1 25 Flint's Physiology. 5 vols., 8vo Cloth, per vol., $4. 50 : Sheep, 5 50 Flint's Text-Book of Human Physiology. 1 vol., 8vo Cloth, $6 00 ; " 7 00 Flint's Manual on Urine. 1 vol., 12mo Cloth, 1 00 Flint's Relations of Urea to Exercise. 1 vol., Svo " 100 Frey's Histology and Histo-Chemistry of Man " 5 00 Hoffmann's Manual of Medicinal Chemicals " 3 00 Holland's (Sir Henry) Recollections of Past Life. 1 vol., 12mo ;1 2 00 Howe on Emergencies. 1 vol., 8vo l - 3 00 Howe on the Breath, and the Diseases which give it a Fetid Odor — 1 00 Huxley on the Anatomy of Vertebrated Animals. 1 vol " 2 50 Huxley and Youmans's Physiology and Hygiene. 1 vol., 12mo " 1 50 Hammond's Insanity in its Relations to Crime. 1 vol., 8vo " 1 00 Hammond's Diseases of the Nervous System. 1 vol., 8vo.. .Cloth, $6 0?; Sheep, 7 00 Hammond's Clinical Lectures on Diseases of the Nervous System. 1 vol.. 8vo, 3 50 Hamilton's (A. McL.) Electro-Therapeutics. 1 vol., 8vo Cloth, 2 00 Johnston's Chemistry of Common Life. 2 vols., 12m o " 3 00 Letterman's Recollections of the Army of the Potomac. 1 vol., 8vo " 100 Lewes's Physiology of Common Life. 2 vols., 12mo " 3 00 Markoe on Diseases of the Bones. 1 vol., 8vo " 4 50 Maudsley on the Mind. 1 vol., 8vo " 3 50 Maudsley's Body and Mind. 1 vol., 12mo " 100 Maudsley on Responsibility in Mental Disease " 1 50 Meyer's Electricity. 1 vol., 8vo " 4 50 Niemeyer's Practical Medicine. 2 vols., 8vo Cloth, $9 00 ; Sheep, 11 00 Neftel on Galvano-Therapeutics. 1 vol., 12mo Cloth, 1 50 Nightingale's Notes on Nursing. 1 vol., 12mo " 75 Neumann on Skin Diseases. 1 vol., Svo " 4 00 New York Medical Journal $4 00 per annnm. Specimen copies, 35 Paget's Clinical Lectures and Essays. 1 vol., 8vo Cloth, 5 00 Peaslee on Ovarian Tumors. 1 vol., 8vo " 5 00 Pereira's Materia Medica and Therapeutics. 1 vol., 8vo Cloth, $7 00 ; Sheep, 8 00 Richardson's Diseases of Modern Life. 1 vol., 12mo Cloth, 2 00 Sayre's Club-Foot. 1 vol., 12mo 4i 100 Sayre's Orthopedic Surgery. With the Operations incident, to Deformities. With numerous Illustrations Cloth, $5 00; Sheep, 6 00 Schroeder on Obstetrics. 1 vol., 8vo Cloth, 3 50 Steiner's Compendium of Children's Diseases " 3 50 Stroud's Physical Cause of the Death of Christ. 1 vol., 12mo " 2 00 Swett on Diseases of the Chest. 1 vol., 8vo " 3 50 Simpson's (Sir Jas. Y.) Complete Works. Vol. I. Obstetrics and Gyne- cology. 8vo. Vol. II. Anaesthesia, Hospitalism, etc. Svo. Vol. III. The Dis- eases of Women Per vol., Cloth, $3 00; Sheep, 4 00 Tilt's Uterine Therapeutics. 1 vol., 8vo Cloth, 3 50 Van Buren on Diseases of the Rectum. 1 vol.. 12mo " 150 Van Buren & Keyes's Genito-Urinary Diseases, with Syphilis. Cloth, $5: Sheep, 6 00 Vogel's Diseases of Children. 1 vol., 8vo Cloth, $4 50: " 5 50 Wells on Diseases of the Ovaries. 1 vol., 8vo Cloth, 5 00 Wagner's Chemical Technology. 1 vol., 8vo " 5 00 Walton's Mineral Springs of the United States and Canada. With Anal- yses and Notes on the Prominent Spas of Europe " 2 00 *** Any of these works will be mailed, post-free, to any part of the United States, on receipt of the price. A large and carefully-selected stock of Medical Works, American and Foreign, constantly on hand. Descriptive Catalogue forwarded on application. Physicians desiring to have their names inserted in our Medical Directory of the United State* and Canada, will please send them in full, with addresses. No charge. D. APPLETON & CO., Publishers, 549 & 551 Broadway, New York. D, APPLETON & CO.'S NEW PUBLICATIONS. The Armies of Asia and Europe : Embracing Official Reports on the Armies of Japan, China, India, Persia, Italy, Russia, Austria, Germany, France, and England. Accompanied by Letters de- scriptive of a Journey from Japan to the Caucasus. By Emory Upton, Brevet Major-General, United States Army. 1 vol., 8vo, 446 pages. Cloth. Price, $3.00. ii. Four Years with General Lee: Being a Summary of the more Important Events touching the Career of General Robert E. Lee, in the War between the States ; together with an Authoritative Statement of the Strength of the Army which he commanded in the Field. By William H. Taylor, of his Staff, and late Adjutant-General of the Army of North- ern Virginia. 1 vol., 8vo. Cloth, $2.00. " It was my peculiar privilege to occupy the position of a confidential staff-officer with General Lee during the entire period of the War for Southern Independence. From the time he assumed the duties of the position of general-in-chief of the Army of Virginia; through the campaign in the western portion of the State ; during the time of his command in the Department of South Carolina, Georgia, and Florida; while he was charged with the control of the military operations of all the armies of the South, at Rich- mond ; and in all his campaigns, when in command of the Army of Northern Virginia— I had the honor to be at his side. Of necessity, therefore, some facts concerning him and the army movements which he directed are known to me, which are not of public record ; and perhaps some value will attach to my statements in regard to those matters of fact which came under my immediate observation, and the recol- lection of which is still fresh in my memory. I propose to speak of these briefly and with entire candor.'''' —Extract from Preface. in. The Last Years of Daniel Webster. A Monograph. By George Ticknor Curtis. 8vo. Paper cover, 50 cents. IV. Gems of the Centennial Exhibition : Consisting of Illustrated Descriptions of Objects of an Artistic Character, in the Exhibits of the United States, Great Britain, France, Spain, Italy, Germany, Belgium, Norway, Sweden, Denmark, Hungary, Russia, Japan, China, Turkey, In- dia, etc., at the Philadelphia Industrial Exhibition of 1876. 1 vol., 8vo. Price, $6.00. v Studies in Spectrum Analysis. (Forming No. 23 of "The International Scientific Series.") By J. Norman Lock- yer, F. R. S. 1 vol., 12mo. Price, $2.50. VI. A Treatise on Chemistry. By H. E. Roscoe, F. R. S., and C. Schorlemmer, F. R. S., Professors of Chemistry in Owens College, Manchester, England. Vol. I. The Non-Metallic Elements. 1 vol., 8vo, 769 pages. Cloth. Price, $5.00. VII. Physiography : An Introduction to the Study of Nature. By Thomas H. Huxley, F. R. S. With Illustrations and Colored Plates. 1 vol., 12mo. Cloth, $2.50. VIII. A Manual of the Anatomy of Invertebrated Ani- mals. By Thomas H. Huxley, LL. D., F. R. S. 1 vol., 587 pages. Cloth, $2.50. D. APPLETON & CO., 549 & 551 Broadway, New York. THE MINERAL SPRINGS OF THE UNITED STATES AND CANADA, WITH ANALYSES AND NOTES ON THE PROMINENT SPAS OF EUROPE, AND A LIST OF 8EA-SIDE RESORTS. BY GEO. E. WALTON, M.D., Lecturer on Materia Mediea in the Miami Medical College, Cincinnati. 1 vol. ISmo. 390 pages, with. JVIaps. Price, $2.00. "In this volume the author has endeavored to arrange all the known facts concerning mineral waters, in such a manner that they shall be readily acces- sible. For this purpose he has cousulted the best European authors, their con- clusions being drawn from hundreds of years of laborious investigation of the spas of Germany, France, Switzerland, and Italy. It has been interesting, in the course of this study, to note how closely the conclusions drawn by them concerning the action of different classes of waters agree with the observations made at springs in this country, independent of any knowledge of foreign re- search. The portion relating to the springs of the United States is the result of a selection of credible evidence regarding them, gained by correspondence and personal observation." — Extract from Preface. The author has given the analyses of all the springs in this country and those of the principal European spas, reduced to a uniform standard of one wine-pint, so that they may readily be compared. He has arranged the springs of America and Europe in seven distinct classes, and described the diseases to which mineral waters are adapted, with references to the class of waters ap- plicable to the treatment, and the peculiar characteristics of each spring as near as known are given — also, the location, mode of access, and post-office address of every spring are mentioned. In addition, he has described the various kinds of baths and the appropriate use of them in the treatment of disease. D. AJPJPLBTON & CO., Publishers, 549 So 551 BROADWAY, NEW YOEK. Sent free % ly mail, to any address in the United States, on receipt of the price. APPLETONS' PERIODICALS. Appletons' Journal : An Illustrated Monthly Miscellany of Popular Literature. Subscription, $3.00 per Annum ; single copy, 25 cents. The Art Journal : An International Gallery of Engravings, by Distinguished Artists of Europe and America. With Illustrated Papers in the various branches of Art. Price, 75 cents per Number, $9.00 per Annum. The Popular Science Monthly. Conducted by E. L. and W. J. Youmans. Containing instructive and interest- ing articles and abstracts of articles, from the pens of the leading scientific men of different countries. Price, $5.00 per Annum ; 50 cents per Number. The Popular Science Monthly Supplement. Containing the best articles from the European periodicals, so that the American reader may keep himself familiar with the thoughts of the great thinkers of the day. Price, $3.00 per Annum ; single Numbers, 25 cents. The North American Review. Published Bi-Monthly. This old and valued periodical, under new and energetic management, has during the past year stepped into the front rank of literature, showing itself the equal, if not superior, of the great Reviews and Quarterlies of the Old World. Per Annum, $5.00 ; per Number, $1.00. The New York Medical Journal, Edited by James B. Hunter, M. D. Terms, $4.00 per Annum. CLUB RATES. Appletons' Journal, Popular Science Monthly, Popular Science Monthly Sup- plement, and North American Review, will be sent to one address for $14.00. D. APPLET0N & CO., Publishers, 549 & 551 Broadway, New York. FINANCE, CURRENCY, AND BANKING. THE EXAMPLE OF FRANCE: Two Essays on the Payment of the In- demnity and the Management of the Currency since the German War, 1870-74. By Victor Bonnet. Translated from the Revue des Deux Mondes by George Walker. Paper cover, 50 cents. PAPER-MONEY INFLATION IN FRANCE: How it Came, what it Brought, and how it Ended. A Paper read before several Sena- tors and Members of the House of Eepresentatives, of botli Political Par- ties, at Washington, April 12, and before the Union League Club, at New York, April 13, 1876. By Andrew D. White, LL. D., President of Cornell University. Price, 50 cents. NOMISMA; or, "Legal Tender." By Henri Cernuschi, author of "Bi-Metallic Money." 1 vol., 12mo, cloth, $1.25. The principal part of the information contained in this volume was given by the au- thor, before a commission appointed by Congress, for the purpose of ascertaining whether it was feasible for the United States to introduce a Bi-Metallic Standard of Gold and Silver. The author is an authority on finance in France, and his information is given in a clear and intelligible form, which cannot fail to be very convincing. CURRENCY AND BANKING. By Bonamy Price, Professor of Politi- cal Economy in the University of Oxford. 1 vol., 12ino. Cloth, $1.50. " His discussion on the subject of currency is very clear and satisfactory, as well as timely." — New-Englander. " The idea that the government stamp on the coin gives to money its value, he dis- poses of in a sentence, yet it is a large part of the money argument." — Hartford Courant. "The author puts forth views as to the mode of resuming specie payments in this country without dogmatism and with common-sense." — Evening Mail. " This is probably the best and most lucid work on the subject." — Sunday Herald, Washington. MONEY AND THE MECHANISM OF EXCHANGE. By W. Stanley Jevons, Professor of Logic and Political Economy in the Owens College, Manchester. 1 vol., 12mo. Cloth, $1.75. " Mr. Jevons's valuable book ought to be read by every statesman, legislator, and journalist, in the United States, who undertakes to discuss the monetary problems of the time." — International Review. "Professor Jevons's work is of the greatest value, and no thinker who cares for his reputation will be willing to leave it unread." — Hartford Post. " His work is properly written, and every page is replete with solid instruction of a kind that is just now lamentably needed by multitudes of our people who are victimized by the grossest fallacies." — Popular Science Monthly. WEIGHTS, MEASURES, AND MONEY, OF ALL NATIONS. Compiled by F. W. Clarke, Professor of Physics and Chemistry in the University of Cincinnati. 1 vol., 12mo. $1.50. " We commend this carefully-prepared and convenient volume to all persons who wish to acquire information on the subject of which it treats." — Boston Globe. " The work necessary to the production of this little volume has been judiciously planned and skillfully executed." — Chicago Tribune. D. APPLETON & CO., Publishers, 549 & 551 Broadway, New York. THE PHYSIOLOGY OF I AIT; DESIGNED TO REPRESENT The Existing State of Physiological Science, as applied to the Functions of the Human Body. By AUSTIN FLINT, Jr., M.D., Professor of Physiology arid Microscopy in the Bellevue Hospital Medical College, New York Fellow of the New York Academy of Medicine ; Member of the Medical Society of the County of New York ; Kesident Member of the Lyceum of Natural History in the City of New York, etc. Complete in 5 vols., 8vo. Cloth, $22.00; Sheep, $27.00; or, per volume, Cloth, $4.50; Sheep, $5.50. Vol. I. Introduction; The Blood; Circulation; Respiration. Vol. II. Alimentation ; Digestion ; Absorption ; Lymph and Chyle. Vol. III. Secretion ; Excretion ; Ductless Glands ; Nutrition ; Animal Heat ; Move- ments; Voice and Speech. Vol. IV. The Nervous System. Vol. V. Special Senses; Generation. General Index to the Work. " The work is free from technicalities and purely professional terms, and, instead of only being adapted to the use of the medical faculty, will be found of interest to the general reader who desires clear and concise information on the subject of man physi- cal." — New York Evening Post. A Text-Book of Human Physiology. designed for the use op Practitioners and Students of Medicine. Illustrated by Three Lithographic Plates and 313 Woodcuts. 1 vol., imperial 8vo. Cloth, $6.00; Sheep, $7.00. D. APPLETON d- CO., 549 & 551 Broadway, New York. DESCRIPTIVE LIST MEDICAL WORKS, PUBLISHED BY D. APPLETON & CO., 549 & 551 Broadway, N. Y. ACADEMY OF MEDICINE (Transactions of the New York), instituted 1847. Second Series, vol. 1. 1 vol., 8vo Cloth, $4 00* ANSTIE (FEANCIS E.) Neuralgia, and Diseases which resemble it. By Francis E. Anstie, M. D., F. E. 0. P., Senior Assistant Physician to Westminster Hospital ; Lecturer on Materia Medica in Westminster Hospital School ; and Physician to the Belgrave Hospital for Chil- dren; editor of " The Practitioner " (London), etc. 1 vol., 12mo. CI., 2 50* BAEKEE (FOEDYCE). On Sea-Sickness. A Popular Treatise for Travelers and the General Eeader. ByFordyce Barker, M. D., Clin- ical Professor of Midwifery and Diseases of Women in the Bellevue Hospital Medical College, etc. Small 12mo . . . , Cloth, 75 On Puerperal Disease. Clinical Lectures delivered at Bellevue Hos- pital. A Course of Lectures valuable alike to the Student and the Practitioner. Third edition. In 1 vol., 8 vo. .Cloth, $5.00*; Sheep, 6 00* BABNES (EOBEET). Lectures on Obstetric Operations, including the Treatment of Haemorrhage, and forming a Guide to the Management of Difficult Labor. By Eobert Barnes, M. D., F. E. C. P., Fellow and late Examiner in Midwifery at the Eoyal College of Physicians ; Ex- aminer in Midwifery at the Eoyal College of Surgeons, London. With Additions by Benjamin F. Dawson, M. D., District Physician to the New York Lying-in Asylum ; Member of the New York Ob- stetrical Society. 1 vol., 8vo. Third edition, revised and extended. Illustrated Cloth, 4 50* BAETHOLOW'S Treatise on Materia Medica and Therapeutics. A new and revised edition. By Eoberts Bartholow, M. A., M. D., Professor of the Theory and Practice of Medicine, and of Clinical Medicine, and formerly Professor of Materia Medica and Therapeutics in the Medi- cal College of Ohio ; Physician to the Hospital of the Good Samari- tan; Corresponding Member of the New York Neurological Society, etc. 1 vol., 8 vo, 548 pages ; . . . Cloth, $5.00* ; Sheep, 6 00* Practice of Medicine (In press.) BASTIAN (H. CHAELTON, M. D., F. E. S.) The Beginnings of Life; being some Account of the Nature, Modes of Origin, and Transfor- mation of the Lower Organisms. With upward of 100 Illustrations. 2 vols., 12mo Cloth, 5 00 Diseases of Nerves and Spinal Cord (In press.) On Paralysis from Brain-Disease in its Common Forms. 1 vol., 12mo Cloth, 1 75 PRICE BELLE VUE and OHAEITY HOSPITAL EEPOETS. Edited by Prof. W. A. Hammond, M. D. 1 vol., 8vo $4 00* BENNET (J. H.) Winter and Spring on the Shores of the Mediterra- nean ; or, The Riviera, Mentone, Italy, Corsica, Sicily, Algeria, Spain, and Biarritz, as Winter Climates. By J. Henry Bennet, M. D., Mem- ber of the Royal College of Physicians, London. With numerous Illustrations. 1 vol., 12mo. New revised edition Cloth, 3 50* On the Treatment of Pulmonary Consumption, by Hygiene, Climate, and Medicine. 1 vol., thin 8vo Cloth, 1 50* BILLROTH (Dr. THEODOR). General Surgical Pathology and Thera- peutics, in Fifty Lectures. A Text-book for Students and Physicians. By Dr. Theodor Billroth, Professor of Surgery in Vienna. Translated from the fourth German edition, by special permission of the author, by Charles E. Hackley, M. D., Surgeon to the New York Eye and Ear Infirmary; Physician to the New York Hospital; Fellow of the New York Academy, etc. 1 vol., 8vo. 152 Woodcuts. New edition. Cloth, $5.00* ; Sheep, 6 00* BUCK (GURDON). Contributions to Reparative Surgery, showing its Application to the Treatment of Deformities, produced by Destructive Disease or Injury ; Congenital Defects from Arrest or Excess of De- velopment; and Cicatricial Contractions following Burns. Illustrated by Thirty Cases and fine Engravings. 1 vol., 8vo Cloth, 3 00* CARPENTER (W. B.) Principles of Mental Physiology, with their Ap- plication to the Training and Discipline of the Mind, and the Study of its Morbid Conditions. By William B. Carpenter, M. D., LL. D., F. R. S., F. L. S., F. G. S., Registrar of the University of London, etc. 1 vol., 12mo , Cloth, 3 00 COMBE (ANDREW). The Management of Infancy, Physiological and Moral. By Andrew Combe, M. D. Revised and edited by Sir James Clark, Bart., K. C. B., M. D., F. R. S. 1 vol., 12mo Cloth, 1 50 CROSS (T. M. B., M. D.) Clinical Lectures on Diseases of the Nervous System. Delivered by W. A. Hammond, M. D., Professor of Diseases of the Mind and Nervous System in the University of the City of New York ; President of the New York Neurological Society, etc. Reported, edited, and the Histories of the Cases prepared, with Notes, by T. M. B. Cross, M. D., Assistant to the Chair of Diseases of the Mind and Nervous System, in the University of the City of New York ; Member of the New York Neurological Society, etc. 1 vol., 8 V0 . Cloth, 3 50* DAVIS (HENRY G.) Conservative Surgery. With Illustrations. 1 vol., 8vo , Cloth, 3 00* DICKSON (J. THOMPSON, M. A., M. B.) The Science and Practice of Medicine in relation to the Mind. Illustrated. 1 vol., 8vo . . . Cloth, 3 50* ECKER (ALEXANDER). Convolutions of the Brain. Translated from the German by Robert T. Edes, M. D. 1 vol., 8vo Cloth, 1 25* ELLIOT (GEORGE T.) Obstetric Clinic : A Practical Contribution to the Study of Obstetrics, and the Diseases of Women and Children. By George T. Elliot, Jr., A. M., M. D. 1 vol., 8vo Cloth, 4 50* FLINT'S Manual of Chemical Examinations of the Urine in Disease ; with Brief Directions for the Examination of the most Common Va- rieties of Urinary Calculi. By Austin Flint, Jr., M. D. 1 vol. Re- vised edition Cloth, 1 00* Physiology of Man. Designed to represent the existing state of Physiological Science as applied to the Functions of the Human Body. By Austin Flint, Jr., M. D., Professor of Physiology and Microscopy PKICE in the Bellevue Hospital Medical College, New York ; Fellow of the New York Academy of Medicine ; Member of the Medical Society of the County of New York ; Kesident Member of the Lyceum of Nat- ural History in the City of New York, etc. Complete in 5 vols. Vol. 1. Introduction ; The Blood ; Circulation ; Respiration. 8vo. Vol. 2. Alimentation ; Digestion ; Absorption ; Lymph, and Chyle. 8vo. Vol. 3. Secretion ; Excretion ; Ductless Glands ; Nutrition ; Ani- mal Heat ; Movements ; Voice and Speech. 1 vol., 8vo. Vol. 4. The Nervous System. 1 vol., 8vo. Vol. 5. (With a General Index to the five volumes.) Special Senses ; Generation. Per vol Cloth, $4.50* ; Sheep, $5 50* The five vols Cloth, $22.00* ; Sheep, 27 00* FLINT'S Text-Book of Human Physiology ; designed for the use of Prac- titioners and Students of Medicine. Illustrated by three Lithographic Plates, and three hundred and thirteen Woodcuts. 1 vol., imperial 8vo Cloth, $6.00*; Sheep, 7 00* The Physiological Effects of Severe and Protracted Muscular Ex- ercise ; with special reference to its influence upon the Excretion of Nitrogen. By Austin Flint, Jr., M, D., etc. 1 vol., 12mo Cloth, 2 00 The Source of Muscular Power. Arguments and Conclusions drawn from Observation upon the Human Subject un- der Conditions of Eest and of Muscular Exercise {In press.) FREY (HEINRICH). The Histology and Histochemistry of Man. A Treatise on the Elements of Composition and Structure of the Human Body. By Heinrich Frey, Professor of Medicine in Zurich. Trans- lated from the fourth German edition, by Arthur E. J. Barker, Sur- geon to the City of Dublin Hospital ; Demonstrator of Anatomy, Royal College of Surgeons, Ireland ; Visiting Surgeon, Convalescent Home, Stillorgan ; and revised by the author. With 608 Engravings on Wood. 1 vol., 8vo Cloth, $5.00* ; Sheep, 6 00* GILL-WYLIE (W., M. D.) Hospitals : History of their Origin, Develop- ment, and Progress, during the First Century of the American Re- public. Boylston Prize-Essay of Harvard University for 1876. 1 vol., 8vo Cloth, 2 50* HAMILTON (ALLAN McL., M. D.) Clinical Electro - Therapeutics, Medical and Surgical. A Hand-Book for Physicians in the Treat- ment of Nervous and other Diseases. 1 vol., 8vo Cloth, 2 00* HAMMOND (W. A.) A Treatise on Diseases of the Nervous System. By William A. Hammond, M. D., Professor of Diseases of the Nervous System and of Clinical Medicine in the Belle vue Hospital Medical College ; Physician-in-Chief to the New York State Hospital for Dis- eases of the Nervous System, etc. New edition, with 109 Illustra- tions. Rewritten, enlarged, and improved. 1 vol., large 8vo. Cloth, $6.00* ; Sheep, 7 00* Clinical Lectures on Diseases of the Nervous System. Delivered at Bellevue Hospital Medical College. Edited by T. M. B. Cross, M. D. 1 vol., 8vo Cloth, 3 50* HARTLEY (W. N.) Air and its Relations to Life and Being, with some Additions, the substance of a Course of Lectures delivered in the Summer of 1874, at the Royal Institution of Great Britain, by Walter Noel Hartley, F. C. S., Lecturer on Chemistry in King's College, London. 1 vol., 12mo Cloth, 1 50* HOFFMANN (FREDERICK, Ph. D., Pharmaceutist in New York). Manual of Chemical Analysis, as applied to the Examination of Me- dicinal Chemicals. A Guide for the Determination of their Identity and Quality, and for the Detection of Impurities and Adulterations. For the Use of Pharmaceutists, Physicians, Druggists, and Manufac- turing Chemists, and Students Cloth, $3 00* HOLLAND (Sir HENRY). Recollections of Past Life. Reminiscences of Men, Manners, and Things. 1 vol., 12mo Cloth, 2 00 HOWE (JOSEPH W.) Emergencies, and How to Treat Them. By Joseph W. Howe, M. D., Visiting Surgeon to Charity Hospital, Clin- ical Professor of Surgery in the Medical Department of the University of New York, etc. 1 vol., 8vo Cloth, 3 00* — The Breath, and the Diseases which give it a Fetid Odor. With Directions for Treatment. 1 vol., 12mo Cloth, 1 00 HUXLEY and YOUMANS'S Elements of Physiology and Hygiene. By T. Huxley and W. J. Youmans. 1 vol., 12mo 1 75 JOHNSTON'S Chemistry of Common Life. 2 vols., 12mo Cloth, 3 00 KEYES. The Tonic Treatment of Syphilis, including Local Treatment of Lesions. By E. L. Keyes, Adjunct Professor of Surgery, and Pro- fessor of Dermatology, B. H. M. C, and Surgeon to Bellevue Hos- pital. 1 vol., 8vo Cloth, 1 00* LETTERMAN (J., M. D.) Medical Recollections of the Army of the Potomac. 1 vol., 8vo , . Cloth, 1 00 LEWES'S Physiology of Common Life. 2 vols., 12mo Cloth, 3 00 MARKOE (T. M.) A Treatise on Diseases of the Bones. By Thomas M. Markoe, M. D., Professor of Surgery in the College of Physicians and Surgeons. With Illustrations. 1 vol., 8vo Cloth, 4 50* MAUDSLEY (HENRY). Body and Mind : an Inquiry into their Con- nection and Mutual Influence, specially in reference to Mental Dis- orders. An enlarged and revised edition, to which are added Psychological Essays. By Henry Maudsley, M. D., London, Fellow of the Royal College of Physicians ; Professor of Medical Jurispru- dence in University College, London, etc. 1 vol., 12mo Cloth, 1 50 Physiology of the Mind. Yol. I. Being the first part of a third edition, revised, enlarged, and in great part rewritten, of "The Physiology and Pathology of the Mind." 1 vol., 12mo Cloth, 2 00 Responsibility in Mental Disease. {International Scientific Series.) 1 vol., 12mo Cloth, 1 50 MEYER (Dr. MORITZ). Electricity in its Relations to Practical Medi- cine. Translated from the third German edition, with numerous Notes and Additions, by William A. Hammond, M. D., Professor of Diseases of the Mind and Nervous System, in the Bellevue Hospital Medical College, etc. With numerous Illustrations. 1 vol., 8vo. . .CI., 4 50* NEFTEL (WM. B., M. D.) Galvano-Therapeutics. The Physiological and Therapeutical Action of the Galvanic Current upon the Acoustic, Optic, Sympathetic, and Pneumogastric Nerves. 12mo Cloth, 1 50* NEUMANN (ISIDOR). Hand-Book of Skin Diseases. By Dr. Isidor Neumann. Translated by Lucius D. Bulkley, A. M., M. D. Illus- trated with 66 Wood Engravings. 1 vol., 8vo. .Cloth, $4.00* ; Sheep, 5 00* NEW YORK MEDICAL JOURNAL. Edited by James B. Hunter, M. D. The largest Medical Monthly published Terms per annum, 4 00* Specimen numbers sent by mail, on receipt of 25 cents. Club Rates : New York Medical Journal and Appletons' Journal, a Household Monthly Magazine V 00 Medical Journal and Popular Science Monthly 9 00 price NIEMEYER (Dr. FELIX YON). A Text-Book of Practical Medicine, with particular reference to Physiology and Pathological Anatomy. Containing all the author's Additions and Revisions in the eighth and last German edition. Translated from the German edition, by George H. Humphreys, M. D., and Charles E. Hackley, M. D. 2 vols., 8vo. Cloth, $9.00* ; Sheep, $11 00* NIGHTINGALE'S (FLORENCE) Notes on Nursing. What it is, and what it is not. 1 vol., 12mo Cloth, 75 ORDRONAUX'S Hints on the Preservation of Health in Armies, for the use of Volunteer Officers and Soldiers. By Dr. John Ordronaux. 18mo Cloth, 38 PAGET. Clinical Lectures and Essays. By Sir James Paget, Bart., F. R. S., D. C. L., Oxon., LL. D., Cantab., etc. Edited by Howard Marsh, F. R. C. S., etc. 1 vol., 8vo Cloth, 5 00* PEASLEE (E. R.) A Treatise on Ovarian Tumors; their Pathology, Diagnosis, and Treatment, with reference especially to Ovariotomy. By E. R. Peaslee, M. D., LL. D., Professor of Diseases of Women, in Dartmouth College ; one of the Consulting Surgeons to the New York State Woman's Hospital ; formerly Professor of Obstetrics and Diseases of Women, in the New York Medical College ; Correspond- ing Member of the Obstetrical Society of Berlin, etc. In one large vol., 8vo. With Illustrations Cloth, $5.00* : Sheep, 6 00* PEREIRA'S (Dr.) Elements of Materia Medica and Therapeutics. Abridged and adapted for the Use of Medical and Pharmaceutical Practitioners and Students, and comprising all the Medicines of the British Pharmacopoeia, with such others as are frequently ordered in Prescriptions, or required by the Physician. Edited by Robert Bentley and Theophilus Redwood. New edition. 1 vol., roval 8vo. Cloth, $7.00* ; Sheep, 8 00* RICHARDSON. Diseases of Modern Life. By Benjamin Ward Rich- ardson, M. D., M. A., F. R. S., Fellow of the Royal College of Physi- cians. 1 vol., 12mo Cloth, 2 00 SAYRE (LEWIS A., M. D.) Practical Manual of the Treatment of Club- Foot. By Lewis A. Sayre, M. D., Professor of Orthopedic Surgery in the Bellevue Hospital Medical College ; Surgeon to Bellevue Hos- pital, etc. New edition. 1 vol., 12mo Cloth, 1 25* Lectures on Orthopedic Surgery and Diseases of the Joints, deliv- ered at Bellevue Hospital Medical College during the Winter Session of 1874-1875, by Lewis A. Sayre, M. D Cloth, $5.00* ; Sheep, 6 00* SCHROEDER (Dr. KARL). A Manual of Midwifery, including the Pa- thology of Pregnancy and the Puerperal State. By Dr. Karl Schroe- der, Professor of Midwifery, and Director of the Lying-in Institution, in the University of Erlangen. Translated into" English from the third German edition, by Charles H. Carter, B. A., M. D., B. S., London ; Member of the Roval College of Phvsicians, London, etc. With 26 Engravings on Wood. 1 vol.^vo. . . .Cloth, $3.50* ; Sheep, 4 50* SIMPSON (Sir JAMES Y.) Selected Obstetrical and Gynaecological Works of Sir James Y. Simpson, Bart., M. D., and late Professor of Midwifery in the University of Edinburgh. Edited by J. Watt Black, M. A., M. D., M. R. C. P. L. ; Physician Accoucheur to Charing Cross Hospital, London, and Lecturer on Midwifery and the Diseases of Women and Children in the Hospital School of Medicine. 1 vol., 8vo. Cloth, $3.00* ; Sheep, 4 00* Anaesthesia, Hospitalism, etc. By Sir James Y. Simpson, Bart., M. D. Edited by Sir Walter Simpson, Bart . . . Cloth, $3.00* ; Sheep, 4 00* SIMPSON (Sir JAMES Y.) The Diseases of Women. By Sir James Y. Simpson, Bart., M. D. Edited by Alexander Simpson, M. D., Pro- fessor of Midwifery in the University of Edinburgh. Cloth, $3.00* ; Sheep, $4 00* SMITH (EDWARD, M. D., LL. B., F. K. S.) Foods. {International Scientific Series.) 1 75 Health: a Hand-Book for Households and Schools. 12mo.. Cloth, 1 00 STEINER. Compendium of Children's Diseases; a Hand-Book for Practitioners and Students. By Dr. Johannes Steiner, Professor of Diseases of Children in the University of Prague, etc. Translated from the second German edition, by Lamson Tait, F. R. C. S., etc. 1 vol., 8vo Cloth, $3.50* ; Sheep, 4 50* STROUD (WILLIAM, M. D.) The Physical Cause of the Death of Christ, and its Relations to the Principles and Practice of Christianity. With Letter on the subject by Sir James Y. Simpson, Bart., M. D. 12mo Cloth, 2 00 TILT'S Hand-Book of Uterine Therapeutics. Second American edition, revised and amended. 1 vol., 8vo, 368 pages Cloth, 3 50* VAN BUREN (W. H.) Lectures upon Diseases of the Rectum, deliv- ered at the Bellevue Hospital Medical College, Session 1869-1870, by W. H. Van Buren, A. M., M. D., Professor of the Principles of Sur- gery, with Diseases of the Genito-Urinary Organs, etc., in the Belle- vue Hospital Medical College; one of the Consulting Surgeons of the New York Hospital; of the Bellevue Hospital ; Member of the New York Academy of Medicine, of the Pathological Society of New York, etc. 1 vol., 12mo Cloth, 1 50* A Practical Treatise on the Surgical Diseases of the Genito-Uri- nary Organs, including Syphilis. Designed as a Manual for Students and Practitioners. With Engravings and Cases. By W. H. Van Buren, A. M., M. D., and Edward L. Keyes, A. M., M. D., Professor of Dermatology in Bellevue Hospital Medical College, Surgeon to the Charity Hospital, Venereal Division ; Consulting Dermatologist to the Bureau of Out-Door Relief, Bellevue Hospital, etc. 1 vol., 8vo. Cloth, $5.00* ; Sheep, 6 00* VAN BUREN (W. H.) Principles of Surgery {In press.) VOGEL (A.) A Practical Treatise on the Diseases of Children. By Alfred Vogel, M. D., Professor of Clinical Medicine in the University of Dorpat, Russia. Translated and edited by H. Raphael, M. D., late House Surgeon to Bellevue Hospital, Attending Physician to the Eastern Dispensary for the Diseases of Children, etc. From the fourth German edition. Illustrated by Six Lithographic Plates. 1 vol., 8vo Cloth, $4.50* ; Sheep, 5 50* WAGNER (RUDOLF). Hand-Book of Chemical Technology. Trans- lated and edited from the eighth German edition, with extensive Additions, by William Crookes, F. R. S. With 336 Illustrations. 1 vol., 8vo, 761 pages Cloth, 5 00 WALTON (GEORGE E., M. D.) Mineral Springs of the United States and Canadas. Containing the latest Analyses, with full Description of Localities, Routes, etc. 12mo Cloth, 2 00 WELLS (Dr. T. SPENCER). Diseases of the Ovaries. 1 vol., 8vo. . . . 4 50* The foremost American Monthly. THE Iff YORK MEDICAL JOUiAL. Edited by JAMES B. HUNTER, M. D., Assistant Surgeon to the New York State Woman's Hospital; Consulting Surgeon to the New York Infirmary for Women and Children; Member of the New York Obstetrical Society, etc. The leading features of this Journal are the following : Original Communications from Eminent Members of the Profession. Reports of Interesting Cases in Private Practice. Notes of Practice in Metropolitan Hospitals, illustrating the Use of New Methods and New Remedies. Translations and Extracts giving the Cream of all the Foreign Journals. Reports on Medicine, Surgery, Obstetrics, Gynecology, Laryngology, Pathology, etc. Critical and Impartial Reviews of all New Medical Books. Proceedings of Medical Societies. Copious Illustrations by means of Woodcuts. The Latest General Medical Intelligence. A General Index to the New York Medical Journal, from its first issue to June, 1876 — including twenty-three volumes — now ready. A new volume of the New York Medical Journal begins with the numbers for January and July each year. Subscriptions received for any period. Terms, $4.00 per Annum, postage prepaid by the Publishers. Remittances, invariably in advance, should be made to D. APPLETON & CO., Publishers, 549 & 551 Broadway, JV. Y. EEGULAR PRICES. The New York Medical Journal per annum, $4.00 Appletons' Journal ------ » 3.00 Appletons' Journal, with plate of " Dickens in his Study" " 4.00 Popular Science Monthly ----- « 5.00 Popular Science Monthly Supplement - - " 3.00 The North American Review .... « 5.Q0 "We Avill send the above-named magazines to one address for one year, for $17.50 — regular price, $20.00 ; with plate of " Dickens in his Study," $18.00— regular price, $21.00. SPECIAL CLUB BATES. New York Medical Journal and Popular Science Monthly, cne year, $8.00 New York Medical Journal and Appletons*' Journal " 6.25 New York Medical Journal and Popular Science Monthly Supplement - 6.25 New York Medical Journal, Popular Science Monthly, and Appletons' Journal " 10.50 New York Medical Journal, Popular Science Monthly, and Popular Science Monthly Supplement - - - ' 10.50 New York Medical Journal, Appletons' Journal, and Pop- ular Science Monthly Supplement " 8.75 The North American Review, when taken in conjunction with any other magazine published by us, will be supplied at $4.50 per annum. APPLETONS' JOURNAL: AN ILLUSTRATED MONTHLY MISCELLANY OF POPULAR LITERATURE. The Brightest, most Readable, and Cheapest, of the High-class Magazines. Contains Serial Novels, Short Stories, Illustrated Papers of Travel and of Picturesque Places, Social Sketches, Essays, Poems, Papers upon Industrial and Scientific Subjects, all by the best writers. Subscription, $3.00 per Annum. Single Copy, 25 Cents. A splendid Steel Engraving: of " Chakles Dickens in his Study at Gadshill" is oftered ex- clusively to subscribers, in addition to the Journal lor one year, for $4.00— that is, for $1.00 additional, each yearly advance subscriber to the Journal will receive a superb engraving worth folly five times the amount. The steel engraving is in line and stipple. It is not a fancy picture, but an actual representation of Charles Dickens in his study at Gadshill, the portrait of the distinguished author being; strik* ingly faithful. The size of the plate is 20 x 14, printed on heavy plate-paper 24 x 30, making a large and hand- some engraving, suitable for parlor or library. The execution of the plate is of a superior order. The ordinary price of a steel engraving of this character in the print-shops would not be less than fi ve dollars. This engraving is entirely new. It has never been for sale in the print-shops, and cannot be obtained except in connection with Appletons' 1 Journal upon the terms given on page 7. It will be mailed to subscribers postage prepaid. Binding-Cases for any volume will be mailed, post-paid, for fifty cents each. THE POPULAR SCIENCE MOITHLY, Conducted by E. L. and W. J. YOUMANS. Containing instructive and interesting articles and abstracts of articles, original, selected, trans- lated, aud illustrated, from the pens of the leading scientific men of different countries; accounts of important scientific discoveries, the application of science to the practical arts, and the latest views put forth concerning natural phenomena, have been given by savants of the highest au- thority. Prominent attention has been also devoted to those various sciences which help to a better understanding of the nature of man, to the bearings of science upon the questions of society and government, to scientific education, and to the conflicts which spring from the progressive nature of scientific knowledge. The Popular Science Monthly; is a large octavo of 128 pages, handsomely printed on clear type, and, when necessary to further convey the ideas of the writer, will be fully illustrated. Terms : Five Dollars per Annum, or Fifty Cents per Number. Postage prepaid to all Sub- scribers in the United States. Binding-Cases for any volume will be forwarded by mail, post-paid, upon receipt of fifty cents. See Club Kates, on page 7. The Popular Science Monthly Supplement, Conducted by E. L. and W. J. YOUMANS. Octavo. Double columns, 96 pages Price, 25 cents. The Popular Science Monthlt was established as a means of giving better expression in this country to two important tendencies of the present age: first, the greatly-increased activity of scientific inquiry, and the enlargement of the sphere of scientific thought; and, second, the grow- ing habit of the leading minds of all countries to contribute their choicest intellectual work for periodical publication. These tendencies have strengthened, year by year, in so marked a degree, that the limits of the Monthly have proved inadequate to secure the object for which it was started. So many excel- lent things were constantly slipping by us for want of space— so many sterling articles by the ablest men in England, France, and Germany, which our readers would prize, and have often called for— that, to make our work effectual, and meet the new demands, we find it necessary to print supplements to our regular issues. We shall issue a supplement of 96 pages eveiy month, price 25 cents, or, by subscription, $3.00 a year, post-paid. Binding-Cases for VolT I. will be forwarded by mail, post-paid, upon receipt ot fifty cents. See Club Rates, on page 7. THE NORTH AMERICAN REVIEW. PUBLISHED BI-MONTHLY. This old and valued periodical, under new and energetic management, has during the past year stepped into the front rank of literature, showing itself the equal, if not the superior, of the great Reviews and Quarterlies of the Old World. Per annum, $5.00 ; per number, $1.00. See Club Rates, on page 7. )