NOTE PARTICULARLY THE LAST THIRD OF PAGE 6. Use Either Metric Weight and Measure all Through, or Commercial Weight and Measure all Through a Formula. *& They are calculated in the same proportion, but the quantities are not, necessarily, the same. The formulas in metric weight and measure, are as directed in the Pharmacopoeia, but as con- verted into commercial weight and measure, they are designed to be for such quantities as the average druggist would most generally make, and, although in the same proportion, the quan- tities may be smaller or larger than the metric weight or measure. For example, Tincture Asafetida, page 164, is but little used. The official formula (metric weight and measure) makes 1000 Cc. equal to 33 fl.ounces-f-390 minims. The formula in commercial weight and measure makes gy% fl. ounces. While in Tincture Cinchona Compound, page 169, which is much more used. 1000 Cc. or nY^ fl. ounces is a more desirable quantity to make. For the same reason we direct a larger quantity of fluid extract to be prepared than the Pharmacopoeia formula directs, because less than about 3 pints of a fluid extract, cannot be made econo- mically. ERRATA. Page 3. Preface 12th line from bottom, read "the 1880 revision directed parts by weight," etc., instead of "the 1890 revision," etc. Page 32. In formula for "Ceratum Resinae" third line, read "Resin 350 gm." instead of "360 gm." In next line below read "(or 5 ounces)" instead of "(or 6 ounces)." Page 99. Eighth line from the top, read "gm." in place of "Cc." after 1000. Page 99. Tenth line from bottom, read "bicarbonate" instead of "carbonate." Page 129. Second line from the bottom, insert "ginger in No. 60 powder, 35 gm. (or 3^4 ounces)." Page 139. In the formula for Spiritus ^Etheris Compositus fourth line, near the end, read "1000 Cc." instead of "3000 Cc." Page 141. Formula for Spiritus Ammonise Aromaticus, insert "oil nutmeg 1 Cc. (or 16 minims)" in the sixth line. Page 146. In formula for Sulphuris Iodidum second line, read "20 gm." instead of "10 gm." Page 175. In formula for Tinctura Lavendulae Composita, insert "Nutmeg 10 gm. (or 150 grains)" in sixth line. Page 176. In formula for Tinctura Moschi, insert "water 450 Cc. (or 1 fl. ounce)" in third line. Fenner's Hand Book OF THE United States Pharmacopeia Seventh Revision, 1890-1893. A KEY TO ALL OFFICIAL PREPARATIONS. Comparing the preparations of the present Pharmacopoeia with those formerly official and converting the metric weight and measure directed in the Pharmacopoeia into proportionate com- mercial weight and measure ; with medicinal uses and doses of new preparations, convenient tables, etc. Compiled and arranged b\ r B. FENNER, Author of Fenner's Complete Formulary, Fenner's Working Formulae, Etc. 1894 Published by B. Fenner, Westfield, N. Y. <0 I4I.Z Copyright 1894 By B. Fenner. By Transfer SEi ^2 Printed By The Fenner Press, Westfield, N, Y, PREFACE. The advent of the Seventh Decennial Revision of. the United States Pharmacopoeia, introducing Metric Weight and Measure in the preparation of its formulas, and otherwise making many important changes in official preparations, without comment or explanation, is the excuse, (if any be needed) for the publication of this volume. Whatever may be the advantages of the Metric S\ T stem of weight and measure in the practice of Pharmacy, the fact remains that it is not the commercial system; and the majority- of druggists, notwithstanding the persistent efforts that have been made to introduce it, are not sufficiently familiar with it to apply it readily in the preparation of medicines. One object of this work is to convert the quantities, expressed in Metric weight and measure in the formulas of the Pharmacopoeia, into propor- tionate quantities, expressed in commercial weight and measure, with which all druggists are familiar. By so doing, the Metric System will be more rapidly acquired by druggists and, at the same time, much tedious calculation and annoyance will be avoided. Another object is to point out the differences between this and the former standard, so that druggists may readily see how preparations which they may have on hand made by former authority^ correspond with the present standard. Physicians and others frequently ask "What is the difference between the present official preparation and that which we have been using for the past 10 years ?" Few druggists can answer such a question intelligently without some con- venient reference, like this Hand-Book. This work is in no sense intended to take the place of the United States Pharmacopoeia, but, is simply an aid for those who find the present Pharmacopoeia slightly in advance of their experience. In a little while, a few years at most, druggists will become familiar with the changes in the present Pharmacopoeia as they have with those of the past ; but mean- while, an explanation, a suggestion, or a comparison will be an aid to the understanding ol the new authority. The Pharmacopoeia of 1870 directed troy weight and apothecar\' meas- ure; the 1890 revision directed parts by weight, of both solids and liquids, except in the case of fluid extracts, pills and troches, where metric weight and measure were introduced; the present, 1890 Pharmacopoeia, directs, chiefly, metric weight for solids, and metric measure for liquids. These changes cannot but be confusing to those who prescribe as well as to those who make preparations, and, taken together with important changes that have been made in the strength and composition of many prepara- tions in the new authority, some work of explanation is a necessity to the majority of druggists. As such this volume is respectfully submit- ted by The Author. Westfield, N. Y., March, 1891. CONTENTS. PRELIMINARY. Preface, 3 Introductory, 6 General Changes Adopted in the Seventh Revision of the United States Pharmacopoeia, , . . . 7 Abbreviations and Signs, 8 HAND-BOOK OF THE UNITED STATES PHAMACOPCEIA 1890-1893. Acetanilidum, .... 9 Abstracta, . . . . . 9 Aceta, 9 Acida, 10 Adeps, 16 ^theres, .16 Alcohol, 17 Aloes, . . . . . .18 Ahimen, 19 Ammonium, 19 Amyl nitris, 20 Amylum, , . . ... .20 Antimonium, 20 Apomorphinae hydrochloras, . 21 Aquae, 21 Argentum, 25 Atropina, 25 Auri et sodii chloridum, ,. . 26 Barii dioxidum, .... 26 Benzinum, . . . 26 Bismuthum, 26 Bromum, 27 Caffeina, . . . . .27 Calcium, • . 28 Calx, . 29 Camphora, .... . 30 Carbo, . . . 30 Catechu, 30 Cera, 31 Cerata, 31 Cerium, . . . 32 Chartae, 32 Chloral, 33 Chloroformum, 33 Cinchonidinae sulphas, 33 Cinchonina, .... 33 Cocainae hydrochloras, 34 Codeina, . . 34 Collodium, .... 34 Confectio, .... 35 Creosotum, .... 36 Creta praeparata 36 Cupri sulphas, . . . . 36 Decocta, . . ' . . . . 36 Elastica, 37 Elaterinum, 37 CONTENTS. 5 Elixira, 37 Physostigmine, . 121 Emplastra, .... 38 Pecrotoxinum, . 121 Emulsa, 41 Pilocarpine hydrochloras, . 121 Eucalyptol, .... 43 Pilule, Pills, . . 121 Extracta, .... 43 Piperinum, . 126 Extracta fluida, . 52 Pix, Pitch, . 126 Fel bo vis purificatum, . 74 Plumbum, . 126 Ferrum, 75 Potassium, . 127 Glycerinum, . . . ' . 81 Pulveres, Powders, . 129 Glycerita, .... 82 P3'rogallol, ... . 131 Glycyrrhizintmi ammoniatum, 83 Pyroxylinum, . 131 Gossypium purificatum, 84 Ouinidine sulphas, . 132 Guaiacum, .... 84 Quinina, , ... . 132 Guarana, .... 84 Resina, . . 133 Hydrargyum, 84 Resorcinum, . 134 Hydrastininae hydrochloras, 87 Saccharum, . 135 Hyoscinae hydrobromas, . 88 Salicinum , . 135 Hyoscyaminae sulphas, . 88 Salol, . 135 Infusa, . 88 Santoninum, . 135 Iodoformum, .... . 90 Sapo, Soap, . 135 Iodum, . . . 90 Sodium, . . 136 Kino, . 90 Sparteine sulphas, . 138 Lactucarium, 90 Spiriti, Spirits, . 139 Limonis succus, . . 90 Strontium, . 145 Linimenta, ..... 90 Strychnin a, . 146 Liquors, . . 92 Strychnina sulphas, . 146 Lithium, ..... 101 Sty rax, .... . 146 Magnesia, .... 102 Sulphur, .... . 146 Manganese, .... 103 Suppositoria, . 147 Massae, 103 Syrupi, Syrups, . 149 Mel, 104 Tamarindus, . . 162 Menthol, .... 105 Terebenum, . 162 Methyl salieylas, 105 Terpini hydras, . 162 Misturae, .... 105 Thymol . 162 Morphina, .... 107 Tincture, Tinctures, . . 162 Mucilagines 107 Triturationes, . 183 Naphthalinum, 108 Trochisci, Troches, . 184 Naphthol 108 Unguenta, Ointments, . . 188 Oleata, Oleates, . 108 Veratrina, . 193 Oleoresinoe, Oleoresins, 109 Vina, Wines, . . 193 Olea, Oils, .... 110 Zincum, .... . 196 Opium, 118 Table of elementary substa nces, 197 Pancreatinum, 119 Table of weight equivalents . 198 Paraldehydutn, . . 119 Table of fluid measure eq niva- Pepsinum, .... 119 lents, . 199 Petrolatum, .... 120 Table of metric equivalents . 200 Phosphorus, .... 121 Index, . 201 INTRODUCTORY. In this hand-book, drugs or substances that are simply gathered, without other preparation for market than curing, drying or treating them for preservation, are not included, but only such drugs or substances as are in some manner prepared by the art of pharmacy or chemistry. For example, Absinthuim, Acacia, Buchu, etc., being naturnl drugs are not mentioned, but Aloes, Camphor, Styrax, etc., being prepared drugs are mentioned, also all official chemical substances and all preparations included in the seventh revision of the United States Pharmacopoeia. This work is designed to be supplementary, only, to the Pharm- acopoeia, giving such information in regard to its subjects, as is most important for druggists to know or learn: — The composition of preparations either chemical or pharmaceutical, formulas for such preparations as it is expedient for druggists to prepare, the relative strength of preparations compared with former authority and the chief properties, uses and doses of preparations or sub- stances newly introduced into the Pharmacopoeia. For convenient reference, also, are noted the specific gravity of most liquid prep- arations, with the freezing and boiling points of many, the melt- ing points of fatty bodies, and the solubility of most definite, solid or crystalline substances in water, alcohol or other common media. Reference is made under each subject to the page of the Pharmacopoeia, and also to the page or pages of Fenner's Com- plete Formulary on which the subjects and further information regarding them may be found. In converting the metric weight and measure of the formulas of the Pharmacopoeia into commercial weight and measure, the amounts which follow the metric in parenthesis ( ) are not de- signed to represent the exact metric weight or measure stated, but only some convenient quantity which will be in the same proportion as is directed of the metric weight or measure. For example Hy- drochloric acid ioo grammes (or 5 ounces by weight), distilled water 219 grammes (or 11 ounces, nearly, by weight) does not mean that 5 ounces is equivalent to 100 grammes or n ounces to 219 grammes, but, that the proportions of the metric weight directed and the commercial weight given are relatively the same. To save continual repetition some abbreviations of our own are used in place of the terms employed in the Pharmacopoeia. They are explained under "abbreviations and signs," and will, we think, be readily understood. (6) GENERAL CHANGES ADOPTED IN THE 7th REVISION OF THE UNITED STATES PHARMACOPOEIA. 1. The expression in formulas, of definite quantities in metric weight and measure instead of in parts by weight as in the sixth revision. 2. The placing of the basic or radical name of a substance be- fore its combining acid or element as Sodium Carbonate, instead of Carbonate of Sodium, Potassium Iodide, instead of Iodide of Potassium, Quinine Sulphate instead of Sulphate of Quinine. 3. The expression of the atomic weight of chemical substances in their true relation with hydrogen taken as 1, according to the latest and most approved authority, for example Oxygen 15.96 in- stead of 16, Bismuth 208.9 instead of 210, etc. See table of atomic weights. 4. The expression of temperature at which the specific gravity of most liquids is calculated at 15 C. (59 F.) instead of 15. 6° C. (6o° F.) as formerly. This is now according to the best usage and authority. In this work we have generally designated the former as N. T., normal temperature, instead of repeating the figures. (7) ABBREVIATIONS AND SIGNS. C Centigrade or Celsius thermometric scale. Cc. Cubic centimeter or cubic centimeters, the present U. S. abbreviation. In the former revision this was C. c. and it is commonly written c. c. Chemical Symbols. See table of elementary substances. F. Fahrenheit thermometric scale. F C F. Fenner's Complete Formulary. < F C F, refer to or see Fenner's Complete Formulary. fl. Before ounce or drachm, fluid, as fl. ounce for fluidounce. Gm. Gramme or grammes. This is the present U. S. abbrevia- tion; it is also commonly written gram or grams. gr. Grain or grains, also abbreviated grn. Because of its simi- larity to gm. the word grain should always be written in prescriptions. Gr. is also used as an abbreviation for gramme in some foreign countries. L. or 1. Litre. This abbreviation is not used in the Pharma- copoeia, but is frequently seen in formulas. M. Mix. Not used in the Pharmacopoeia, but very common in formulas. N. Normal. Used in the U. S. test solutions as T =normal, Tj=seminormal, y ? Q -=decinormal, y^-g-^centinormal. N. T. Normal Temperature. Our own abbreviation for the tem- perature at which specific gravity is generally taken; 15 C. (59° F.). Pharm. or P. Pharmacopoeia. May refer to any Pharmacopoeia, or to the present or former U. S. authority. U. S. P. is also used. sp. gr. Specific gravity, sometimes, also, written s. g. T. S. Test Solution. Abbreviation not heretofore used in the U. S. P. U. S. The United States Pharmacopoeia, also U. S. P. In this work U. S. refers to the present (1890) Pharmacopoeia. at, a large part ot its water being vaporized. Phosphoric acid unites with bases forming salts calkd phosphates. ACIDUM PHOSPHORICUM DILUTUM. Diluted Phosphoric Acid. The present Pharm. directs phosphoric acid (85 per cent.) 1 x) gm. (or 2 ounces, by weight,); distilled water 750 gm. (or 15 ocuices, by weight), to make 850 gm. (or 17 ounces, by weight). The absolute acid strength of this preparation is the same as in the 1880 Pharm., 10 per cent. Its sp. gr. is about 1.057 at N. T. Particular attention must be observed in making this preparation to know the standard of acid strength from which it is prepared. If the 1880 50-per cent, acid is used, follow the old lormula, 2 parts or ounces, by weight, with 8 parts or ounces of distilled water. remaining soft and adhesive after cooling. When heated together with 12 to 15 per cent, of sulphur it becomes more or less hard or "vulcanized." ELATERINUM. Elaterin. C 20 H 28 O 5 . "A neutral principle obtained from elaterium, a substance deposited by the juice of the fruit of ecballium elaterium." P 477- 6o fenner's hand-book of It will be noted that acetic acid is directed in the present Pharmacopoeia instead of hydrochloric acid as was directed in the former revision. The temperature at which the percolate is evaporated should not exceed 5o°C. (I22°F.). EXTRACTUM ERIODICTYI FLUIDUM. Fluid Extract of Eriodictyon. new. Eriodictyon, in No. 60 powder, 1000 gm. (or 3 pounds av). Alcohol and water, each, a sufficient quantity to make 1000 Cc. (or 46 fl. ounces). Alcohol 4 measures with water 1 measure are mixed and a fluid extract prepared as directed in the general formula. The tem- perature at which the percolate is evaporated should not exceed 5 o°C. (i22°F.). fl. ounces of alcohol and 180 Cc. or (8 fl. ounces of water), and this is to be used for moistening the drug and as the first menstruum for the percola- tion, to be followed with a menstruum made in the proportion of 4 measures of alcohol to 1 measure of water, until the drug is ex- hausted. The fluid extract is then prepared as directed in the general formula. fenner's hand-book of Wanted for use the magnesia mixture is to be vigorously shaken and added gradually to the iron solution and the whole shaken together until a uniform mixture results. In poisoning by arsenic this is to be freely given, the whole quantity being used if neces- sary. . The percentage of calcium hydrate varies with the temperature, being somewhat over 0.17 per cent, at N T, and diminishing as the temperature rises." fl. drachms), solution of ammonium acetate 200 Cc. (or 1^ fl. ounces), aromatic elixir 100 Cc. (or % fl. ounce), glycerin 120 Cc (or y% fl. ounce), water a sufficient quantity to make 1000 Cc. (or 5 fl. ounces). To the solution of ammonium acetate (which should not be alkaline) the diluted acetic acid, the tincture of ferric chloride, the aromatic elixir and the glycerin are successively to be added, and lastly, enough water to make the measure 1000 Cc (or 5 fl. ounces). This preparation should be freshly made when wanted for use, hence the small quantities directed. 2> 7 /^ fl. ounces). potassium hypophosphite 1 gm. (or 55 grains), tartaric acid 12 gm. (or iy 2 ounces av.), water 15 Cc. (or 1^ fl.ounces), diluted alcohol and syrup, each, a sufficient quantity to make 1000 gm. (or 12^ ounces av.) The potassium salts are to be dissolved in the water, and the tartaric acid in 25 Cc. (or 3 fl.ounces) of diluted alcohol. The two solutions are then to be mixed in a vial and shaken thoroughly and placed in ice water for half an hour, shaking oc- casionally. The mixture is then to be filtered through a small, rapidly acting white filter paper, the vial carefully washed with diluted alcohol and the washings passed through the filter until the filtrate ceases to produce more than a faint cloudiness when a drop or two is allowed to fall into silver nitrate test-solution. The filtrate is then to be reduced by evaporation in a tared capsule on a water-bath to 50 gm. (or 6 1 ^ ounces av.), and when cold, enough syrup is to be added to make the product weigh 1000 gm. (or 12% ounces av.). p 418. F C F, p 912. TINCTURA HUMULI. Tincture of Hops. Hops, well dried and in No. 20 powder, 200 gm. (or 7 ounces av.), diluted alcohol a sufficient quantity to make 1000 Cc. (or 33I fl. ounces). 'i he powder is to be moistened with 400 Cc. (or i^V- fl. ounces) IMF. U.S. PHARMACOPOEIA. 173 of diluted alcohol and macerated for 24 hours; then packed firmly m a percolator and diluted alcohol gradually poured upon it until 1000 Cc. (or 33} fl ounces) of tincture are obtained. ounces av.), alcohol a sufficient quantity to make 1000 Cc. (or 14V2 fl. ounces). 1 82 fenner's hand-book of The balsam of tolu is to be macerated with 900 Cc. (or 12 fl. ounces) of alcohol until it is dissolved, then filtered through paper and enough alcohol added through the filter to make the tincture measure 1000 Cc. (or 14^ fl. ounces). 2, S A> A. ounces). The ginger is to be moistened with 50 Cc. (or 2 fl. ounces) of alcohol and macerated for 24 hours. It is then to be packed firmly in a percolator, and alcohol poured gradually upon it, allow- ing it to percolate slowly until 1000 Cc. (or 33-I fl. ounces) of tinc- ture are obtained.