FATTY ILLS AND THEIR MASQUERADES BY EPHRAIM CUTTER, LL.D., M,D. Harvard, 1856, and University of Penn- sylvania, 1857 AND JOHN ASHBURTON CUTTER, B.Sc, M.D. Albany Medical College, 1886 Corroborator Being a contribution to clinical medicine for practitioners and students, to emphasize the inestimable value of the microscope in detecting the pre-stages of amaurosis, angina pectoris, apoplexy, Bright's disease, cataract, dementia, fatty heart, gall stones, glaucoma, hsemato- philia, locomotor ataxia, etc., and the like value of American means of treatment in these pre-stages and in those advanced states usually considered incurable Equitable Building 120 Broadway, New York THE AUTHORS I89S 1*3 This matter herewith published was delivered in part by lectures to the College of Physicians and Surgeons of Boston by the prime writer during 1894-95, Copyright, January, 1898, by Ephraim Cutter and John Ashburton Cutter M |?i*fer of IVED. J*> \ ^ ^ Vo Press of STKTTINKR BROS., 22-26 Reade Street, New York TABLE OF CONTENTS. DEDICATION, V-VI PRELUDE, VII-VIII DEFINITIONS IX-XIV I. FATTY DEGENERATIONS THAT ARE NORMAL, i II. FATTY ILLS WHICH ARE AB- NORMAL AND RECOGNIZED AS FATTY DEGENERATION, . . 3 III. MASQUERADES OF FATTY ILLS, 3b IV. FATTY DEGENERATION A PRE- SERVATIVE PROCESS, . . 60 V. THE DIAGNOSIS OF FATTY DE- GENERATIONS, .... 61 VI. THE TREATMENT OF THE FATTY ILLS AND THEIR MASQUE- RADES, 79 VII. SPECIAL AND PARTICULAR TREATMENT, WITH ILLUS- TRATIVE CASES, . . .140 VIII. BIBLIOGRAPHY, 177 IX. APPENDICES, . . . . . 1S1 X. INDEX, '" . 1S7 DEDICATED TO DR. G. N. TIENHOVEN, Physician to the Queen of Holland, etc. DR. FREDERICK SEMELEDER, Surgeon-in-Chief to Maximilian, in Mexico, etc. DR AUGUST MARTIN, Chairman of the Section on Gynecology, Tenth Inter- national Medical Congress, etc. SIR JOHN BANKS, K.C.B., Dublin. SURGEON-MAJOR J. H. JOHNSTON, B.A., Aldershot. LEWIS A. SAYRE, M.D., President American Medical Association, 1880; Emeri- tus Professor of Orthopaedic Surgery, Bellevue Hospital Medical College, etc. T. GAILLARD THOMAS, M.D., LL.D., Emeritus Professor of Gynecology, College of Physi- cians and Surgeons, New York, etc. ALBERT VANDER VEER, M.D., Ph.D., Professor of Surgery, Albany Medical College; Re- gent of the University of the State of New York, etc. JOHN B. HAMILTON, M.D., LL.D., Supervising Surgeon-General, Marine Hospital Ser- vice of the United States, 1879 to l $9 l \ Professor Principles of Surgery and Clinical Surgery, Rush Medical College; editor "Journal of the American Medical Association," etc. ROBERT NEWMAN, M.D., President American Electro-Therapeutic Society, etc. V DEDICATION. HENRY A. ROBBINS, A.M.,M.D., Washington, D. C. PROF. S.WEIR MITCHELL, M.D., LL.D., Clinician, author, etc., of Philadelphia. PROF. J. SOLIS COHEN, M.D., Philadelphia. JOHN V. SHOEMAKER, M.D., LL.D., Professor of Materia Medica, Pharmacology, and Therapeutics, Medico-Chirurgical College; editor of the " Medical Bulletin," etc. HENRY O. MARCY, M.D.,LL.D., President American Medical Association, etc. SAMUEL W. ABBOTT, A.M., M.D., Secretary Massachusetts Board of Health, etc. AUGUSTUS P. CLARKE, M.D., Dean of the College of Physicians and Surgeons, Bos- ton; Honorary President Section on Gynecology, Twelfth International Congress, 1897, etc. G. ARCHIE STOCKWELL, M.D., Editor of the "Medical Age," etc. I. N. LOVE, M.D., President Mississippi Valley Medical Association; edi- tor of the " Medical Mirror," etc. LANDON B. EDWARDS, M.D., Professor of Practice of Medicine, University College of Medicine; editor "Virginia Medical Semi- Monthly," etc. LEVI C, LANE, M.D., LL.D., Founder Cooper Medical College, San Francisco. GUSTAVUS L. SIMMONS, M.D., President California State Medical Society. DEERING J. ROBERTS, M.D. Editor " Southern Practitioner," Tennessee. PROF. DUDLEY S. REYNOLDS, M.A., M,D., Louisville. SAMUEL K. CRAWFORD, M.D., Chicago, 111. vi PRELUDE. The prevalence and fatality of diseases whose essence is fatty degeneration make them a subject of importance, especially as it is now, though not generally, known that they are curable. To have this fully understood means a rewriting of the science and art of medicine, as chemistry and electricity are being rewritten within the last twenty or more years. But this is no hardship, since the busi- ness of the medical profession is to cure dis- eases as well as to write them up. If there is any light to throw on fatty degenerations, there is need of such writing, regardless of the personal equations of the illuminator and the illuminated. So if this dark subject is made brighter and clearer, or if a cue is given to make it clearer and brighter, the end will be gained, which is to show : I. What fatty degenerations are normal. II. What fatty degenerations are abnormal. III. The fatty degenerations that are mas- querades — *.*., diseases which really are fatty ills, but which are called by other names giv- ing no idea of their true character and are therefore misleading. IV. That fatty degeneration is supposed to be a preservative process. V. The diagnosis of fatty degeneration : (a) By the morphology of the blood. (b) By the morphology of muscular tissue. (c) By the morphology and chemistry ©f the urine. vii Vlll (a) By auscultation, percussion, mensu- ration, palpation. VI. The treatment — by food, by medicines, by forms of motion such as music, vital dy- namis, massage, and by proper management, illustrating the highest art of the physician. VII. Special and particular treatment, with illustrative cases. VIII. Partial bibliography. EPHRAIM CUTTER. Note. — The corroborator has had little to do with the actual writing of this clinical contribution to medi- cine beyond the case histories in his own practice and some suggestions and emendations to the manuscript. He witnesses to the value and truth of what is herein laid down. JOHN ASHBURTON CUTTER. DEFINITIONS. WHAT IS MEANT BY FATTY DEGENERATION ? ''It is the replacing or substitution of nor- " mal tissues or parts of normal tissues by " some form of liquid, solid, crystalline, cel- " lular, intercellular, or interstitial fat," or " the abnormal deposition of fatty matters in " the histological elements of animal bodies" (Micrographic Dictionary, London, 1883). To use language, as we do when we say "the sun rises/' to set forth a perfectly in- telligible fact though not scientifically ex- pressed, we mean that fatty degeneration in- cludes the oily, the lardaceous, the waxy, the hyaline, the tallowy, and the amyloid and sclerotic degenerations sometimes accom- panied by beautiful pigments and calcareous deposits. As a general thing, fatty degenera- tions are recognized after death with ease; but it is the duty of physicians to recognize fatty ills before death by the use of a means of knowledge which the Nederlands conferred on the world three hundred years ago — i.e., by the microscope. TWO GREAT PRIME CAUSES. First. The English idea is that fatty ills are "due to retarded or impeded functions or circulation"; or that "when the normal functions of the morphological elements of a tissue become languid or interrupted, free globules of fat or oil become deposited in them; and, as this fatty deposit is increased, the tissue loses, to a greater or lesser extent, ix its natural vital and physical properties, and hence is said to be in a state of fatty de- generation ° ( Micrographic Dictionary). This is seen in the destruction of horses by high feeding without proper exercise. Veter- inarians say that the muscles turn into fat. When ligatures about human limbs do not wholly obstruct the circulation, the effect is to produce fatty degeneration, especially of the muscles. Henry O. Marcy , M.D., LL.D., reports a case where he per- formed cholecystotomy for stones impacted in the gall bladder, and found even the fibrous tissues of the gall bladder fattily degenerated and rotten, partly due to the enormous pressure exerted by the stones. This causal principle of pressure holds true of the vegetable kingdom as well as of the animal. Some years ago I studied the morphology of New England autum- nal foliage. In the maple leaf, for exam- ple, it was found that the stem ducts were half-obliterated by a hyaline, glassy sub- stance evenly deposited inside the walls of the ducts; that the interlaminal parenchy- ma of the leaf was well filled with granular and globar fat, and that the chlorophyll was undergoing other molecular changes which seemed to be due to cutting down of the sap supply by the aforesaid diminu- tion in the normal calibre or lumen of the stem ducts. Again, in studying the morphology of rotten apples, I took an apple with a smooth facet made by the barrel-head, which facet looked discolored and rotten. Cutting into it, the substance felt hard and inelastic in place of soft and punky. This unexpected feel caused a careful microscopic examination, which showed an abundance of starch-like (amyloid) bodies, along with fat globules and gran- XI ules. I thought to find broken-down cells of apple protoplasm gracefully entwined with exquisitely fine mycelia of the fully developed fungus of rotten-apple fermen- tation vegetation. It seemed to me that the long-continued pressure of the barrel- head on the apple had retarded the inter- and intracellular circulation of the apple fluids; and hence, according to this doc- trine, resulted the fatty degeneration. At least, this rationale is satisfactory till a better appears. Apple amyloid has been found in the bark by others, but not be- fore in the apple substance, according to my knowledge. The fat formed in corn, peach stones, nuts, and in suet meats is normal fat. Second Great Cause— Fatty Ills Come from Food. (a) Fatty food in excess, as seen in the production of the fatty liver of Strassburg geese kept in close confinement, as a gour- mand's delicacy; and as shown by experi- ments in feeding animals on fat foods, reported in text books of physiology. (b) Food in excess containing carbon, hy- drogen, and oxygen, as seen in fruits, sugars cakes, candies, pies,and other such produc- tions of the vegetable and animal king- doms which have few mineral elements and are mostly made up of carbohydrates, as fats are. (See list of sugars, Appen- dix B.) That is to say, we must ex- pect fatty ills to occur when the food is of the same ultimate chemical elements as fat, but differently arranged in molecular combination. For example, an exclusive diet of starch, if it could be lived on long enough, should be expected to produce the substitution of normal tissues by fat. Xll Dr. W. A. Hammond once tried to live on starch alone, but the results were so dis- astrous that his friends obliged him to desist. Dogs fed on white flour alone died in forty days. Dogs lived on water alone for forty days. The late Joseph Jones, M.D., LL.D.,by experiments in changing the food of car- nivorous chelonians to vegetable food — i.e. pursley — showed fatty degeneration as one result (Smithsonian Contributions to Knowledge, 1856). To repeat : As fats are carbon, hydrogen, and oxygen, and as starches and sugars, wherever found, are carbon, hydrogen, and oxygen, it is natural, from a chemical point of view, to expect fatty degeneration to result from feeding on starch and sugar foods exclusively. The phyto-chemistry of our bodies is something wonderful; but it would be more wonderful if from car- bon, hydrogen, and oxygen it could evolve lime, phosphorus, sulphur, fluorine, and the other ultimate chemical elements which are part and parcel of our bodies.* (c) But there is an A merican idea as to the cause of fatty degeneration, which is all- operative, cogent, impressive, positive, and often must be present, to wit: that the fer- mentation of food in the alimentary canal produces gases which directly and in- directly paralyze, impede, and hinder func- tions, so that the gases act very much as if the circulations connected with said functions were obstructed mechanically by a string or ligature. This division might come under our first head, and also might come under the second head, as carbo- hydrates constitute the most fermentable * Some chemists claim forty elements in the human body. Xlll foods. Its unrecognized importance en- titles it to a distinct recognition and sep- arate statement; besides this, it will be better remembered by all concerned. The said fermentation is probably the most efficient cause of fatty degeneration that clinicians can get at and handle, and which indeed they handle now, as it were, in the dark. If a more direct statement is asked for, it cannot be said why, the circulation being impeded by either one or all of the causes named, the muscle cell parts with its contractile and tensile characters and takes on fatty, fragile, untensile and un- textile characters, any more than we can tell why phosphorus in poisonous doses causes the same fatty degeneration of the cardiac muscles and death in the extremely short space of twenty minutes time, nor why the epithelia of the mammary glands secrete milk and the hepatic epithelia se- crete bile, though both are normal fat producers. Here man stands on the con- fines of his limits and meets the incompre- hensible boundaries of Nature, or rather of God, the Creator of Nature. Man can only say that these facts are as they are. To take a simple illustration: Who can tell why gold is yellow and silver white ? You say that their nature is to produce vibra- tions of light which also produce on us the said visual impressions. Any better an- swer than the child's " God makes them so"? I have been using the microscope since 1850, and Tolles' famous one-fiftieth and one-seventy-fifth inch objectives since 1876. I have not yet learned the solution of these mysteries, though others may; but so long as treatment on the lines laid down in this clinical contribution has enabled Nature to remove fattily degenerated tissues, and XIV in their place has reproduced normal tis- sues, there is a much better basis to work on than those now operated for the relief of this class of cases. Nature cures fatty- ills when causes are removed and she is furnished with plenty of dynamis* to work with. * Dynamis here means virtue or force, inherent, actual and potential, or vital energy, sometimes called " animal magnetism " for want of a better name. In the New Testament dynamis means virtue or inherent power to produce effects; ability, authority, efficacy, efficiency, energy, might, miracle, right, strength. " Metonomically, the Almighty, who possesses power and authority." (Greek Testament lexicon.) I. FATTY DEGENERATIONS THAT ARE NORMAL. This chapter may seem out of place, as it clashes with the definition; still, normal uterine subinvolution and the clinical morphology of puerperal discharges beau- tifully demonstrate fatty epithelia, oil globules, and muscular fibres of uterus, large, long, flat, pointed at both ends, and undergoing fatty degeneration, whereby the organ is reduced to normal in a few weeks if health is good. There is normal ovarian subinvolution in the Graffian follicles or corpora lutea of the ovaries after ovulation. Epithelial cells of the kidneys, according to one author; epithelia of the breasts producing fat of milk; epithelia of the sebaceous glands; corpora amylacea, or amyloid bodies found in the brain, called " brain sand," and considered as normal by some writers, come under this chapter. If the diseases due to old age are nor- mal, then, as most of them are fatty ills, they are diseases due to normal conditions. At least, it is maintained that death from old age is a natural death, or that the way in which death comes by molecular changes when the normal limit of life is reached is natural. " The thing that is seen is temporal " applies to the animal and vegetable kingdoms. Organic life has periods of termination to its existence, while spirit is "eternal." Adipocere, though not a clinical change, may be mentioned here. Corpses have been known to turn, after burial generally for years, into a hard, fat, waxy substance, and portions of human muscle have under- gone the same change when kept under water. Adipocere is regarded as a chemi- cal change which certainly prolongs the existence of the parts thus changed, and, though a degeneration, it is a preservative one after death. Obesity is an accumulation of fat where it naturally belongs in the human body, but does not necessarily include the sub- stitution of other tissues by fat, though the two conditions are sometimes found together. Excessive obesity may become a fatty ill, and then is amenable to the same treatment as the latter. The obese, save from the inconvenience of ex- cessive bulk, are to be regarded as in a normal condition until there is an invasion of tissues and organs and these are more or less replaced by fat. When obesity and fatty degeneration are found together, skill in diagnosis is well displayed in deter- mining the existence of the latter. The two conditions are popularly connected together, and generally obesity is thought to precede and induce fatty degeneration; but the fallacy of this is shown by lean people presenting the most typical cases of tatty degeneration of tissues and organs. The offices of fat in the healthy body are too well known to need repeating here. They are needful to perfect living; but when omental fat accumulates in masses as large as a man's hand, it is "obesity" and as much a condition of disease as it would be to have one's arm four feet long. Obesity is amenable to diet more than any other means, and does not have the proper attention from the profession; hence the demand for adver- tised nostrums. II. FATTY ILLS WHICH ARE ABNORMAL AND RECOGNIZED AS FATTY DEGENERATION. Premature old age. Fatty Heart. Fatty Liver. Fatty Kidneys. Fatty Muscles, especially of limbs. " Not only do muscular tissues, but also "capillary, venous, and arterial vessels, " connective fibrous tissues, epithelia, in- " tercellular and areolar fat tissues, glandu- "lar structures, and even tuberculous a lungs, fattily degenerate." * A common example is the subcutaneous solid fat becoming oils, and in the writer's estimate this is an important primal link in the chain of evidence necessary to estab- lish the diagnosis of fatty ills, of which more later. Fatty thyroid glands occur in acute diseases. " Cancer cells and cells of inflammatory " exudation, when their functions have at- tained their full development and cease, "fattily decay. The flesh and other pro- "tein components of one animal, when "kept in the peritoneal cavity of another "animal, will undergo fatty degenera- tion."* * Micrographic Dictionary. 3 3a The fatty degeneration, acute, which occurs in phosphorus poisoning, and lately noted in a case of death from eating a bad oyster, raw, where death ensued in a few hours.* Probably also in water-gas poisoning. * Editorial New York Medical Journal^ 1896. III. MASQUERADES OF FATTY ILLS. The effort is to show that clinicians should consider systemic conditions more than theoretical names if they wish suc- cess to crown their labors. While one must respect old names as vehicles of thought and information, he must be guided so as to remove abnormal condi- tions which were unknown when our nomenclature of disease was made up. At the same time, the medical men of the past must not be dishonored, since if they "did not know everything, they knew something, and knew enough to name causes of heart failure, " and who made the best use of what they had. Some time medicine will be rewritten on these lines, for the reason that it is foolish to fritter away opportunities of doing good by the use of defective " nouns *' that masquerade the results of fatty degeneration. It is not well to treat disease by names. We should treat their essence, unmask all physiological sins of their disguises, call " a spade, a spade," go for the lesion causes, remove them as far as possible and give Nature a chance to cure. These are so many masquerades of Fatty Ills that a brief alphabetical mention of them will be made, as follows : 3b Alcoholism is a masquerade of fatty ills. A friend suggests King Alcohol wears the mantle of fatty degeneration. It certainly is a carbohydrate; it certainly makes fatty noses, livers, kidneys, hearts, brains, etc.; it loads down all the systemic functions when used in excess. Alcoholism may be termed an acute locomotor ataxia, acute dementia, acute softening of the brain, acute idiocy, acute mania, acute epilepsy, so much so that it seems wise to introduce it here as a mas- querader. Again, the alcohol and carbonic acid gas found inside the alimentary canal of veg- etable eaters are factors in producing fatty ills. Amaurosis, or partial or total loss of vision, from paralysis of the retina; and I presume most of my readers would not admit it is a masquerade of fatty degeneration. But such is a fact, and I do not feel at liberty to leave it out, notwithstanding the evidence is not so clear as in the other masks; and the convic- tion this is true is forced after long con- sideration, owing to the fact oculists assert amaurosis is mainly due to an excess of car- bohydrate diet and that paralysis of the retina may be due to, and is part and parcel of, fatty degeneration. "According to some statistics," says Weir Mitchell, "out of one hundred and fifty cases of Bright's disease of the kidneys, fifty have retinal complica- tions."* The complex structure of the eye being of terminal tissues where the circulation has to *" Diseases of Women," Doctor McNaughton Jones, page 82, London, 1890. 5 stop and turn back on itself, furnishes facili- ties for impeded or retarded circulations and renders it easier for paralysis to supervene than would be the case if the channels ran straighter; indeed the eye is often the first organ to suffer from fatty degeneration, as oculists have shown. Amyloid is a starch-like body or bodies, appearing and disappearing in the urine in the first stages of Bright's disease. The mammae and the liver have at times been found to be almost wholly amyloid; the same bodies are found in the brain, and many imagine they are normal — definite evidence that the line of demarcation be- tween health and disease is not always clean cut. People apparently in good health pre- sent signs of latent disease; and so amyloid de- generation may come under both conventional health and conventional disease; at any rate, from the close affiliation of amyloid with normal fatty degeneration I think it should be regarded as one of the early stages of the latter, from a clinical point of view, for I have found this estimate safe and useful. Treated as a fatty degeneration I have seen amyloid yield very readily and permanently disap- pear. Note, however, that care must be take to distinguish starch grains from amy- loid bodies. The consensus of all medical opinion, as far as known, is that angina pectoris is due to calcareous deposits in, or degeneration of, the coronary arteries; these deposits are of the nature of fatty degeneration of the circular muscular fibers of these arteries, and are made up of atheromatous matters, mostly cholesterine, which attain a hardness like stone; hence the term "calcareous." Lime deposits also occur along with the purely fatty, and their deposition also is probably due to the retarded and impeded circulation, and to the want of sufficient fluid in the sys- tem to keep the lime salts in solution. It is easy to see how fatty degeneration of the heart substance may follow the partial oblit- eration of the coronary arteries. There is mechanically retarded function, and likewise an element of neuralgia, which may be ex- plained by the deposits diminishing the sup- ply of nerve force because they partially cut off the normal blood-supply, and by a partial paralysis of the heart muscles because in their ill-fed condition the interval between the beats is not sufficient for rest and because they thus overwork. Overworked muscles are apt to have painful cramps, as in writer's and organist's paralysis; hence one cause of the choking pain, " angina," in the over- worked and ill-fed heart muscles. Again, it has been reported, to anticipate a little, when facial neuralgia has been relieved by extirpa- tion of the Gasserian ganglion or the infra- orbital nerve, that the ganglion and nerve have been found to be affected with fatty degeneration so frequently that this latter may be suspected to be a cause of the neu- ralgia, and that its treatment should be by Nature's own processes of metabolism rather than by the surgical changes wrought by the knife. I know of one case of surgical inter- ference and removal of ganglion for facial neuralgia in which the pain returned in ten days and persisted until death. Why? 7 No surgeon could treat angina pectoris by extirpating the cardiac arteries or ganglia, but they can treat it through the interstitial and profound influences of proper nutrition, which obtain and reign in the most hidden, profound and vital parts of the body sys- temic. In order to give point and force to these words, the writer may be allowed to state that he has seen cures of this masquer- ade performed on these principles. Aphasia is a term signifying loss of speech — literally dumbness; but medical language is flexible and does not mean that altogether, and it is employed rather to signify inability to use language fluently; it is the loss of a perfectly familiar word where the speaker knows what should be said but is unable to speak it. This in my opinion is nothing but a result of fatty degeneration of the nerve- ganglia centers in which is located the func- tion of speech; and this degeneration is undoubtedly acute as well as chronic, while both are amenable to treatment by food, music, rest, and management. Apoplexy is another very common mas- querade. The essence of sanguineous apo- plexy is when blood escapes from the cerebral basilar arteries, and is forced by vascular pressure into the substance of the brain or into the cerebral ventricles. It forms a clot, as blood usually does outside of live arteries, veins and capillaries, which clot by its abnor- mal pressure paralyzes usually the other side of the head or body more or less completely — sometimes pressing on the ganglia of the pneumogastric nerve and instantly producing death; at other times usually entailing a loss 8 of consciousness and motion, so that the erect subject falls as if struck on the head by a club or stone. But the real clinical, essential and exciting cause of apoplexy is the rupture of an artery by normal blood-pressure. The popular idea that apoplexy arises from an increased force of circulation has some foun- dation, but not the special significance that it arisef from a weakening of the arteries by changing their substance partly into the flabby, soft, weak body of oil, lard, tallow, or grease. While it is true that an increased force of circulation is a causal element of apoplexy, it is truer that the degenerated artery gives way under normal heart pressure often during sleep, which is usually the quietest part of man's existence. To repeat, the essence of sanguineous and possibly of the serous apo- plexy is a fatty degeneration. In addition, some writers state that the brain tissue around the diseased arteries is softened probably by the same degeneration, which if true only makes the claim stronger that this malady is a masquerade to be exposed by a better nomenclature if possible. The succession of apoplectic shocks or fits is explained by suc- cessive portions of the arteries becoming successively softened by the fatty degenera- tion progress, and giving way. It is merely a question of time, some parts degenerating sooner than others. The rational treatment of apoplexy should be directed to the diag- nosis and removal of the fatty degeneration and the substitution of normal tissues. • In retinal apoplexy appear the same caus- ative lesions as in cerebral apoplexy: The muscular coats of the retinal arteries are softened by fatty degeneration in some form, and the normal heart pressure ruptures the vessels; the ophthalmoscope diagnoses the extravasation and the clots in the retinal substance. Were the real lesion of retinal apoplexy not concealed by its name it would be better, for then relief would probably be sought in an endeavor to eliminate the pre- disposing fatty degeneration. Arcus senilis, the senile ring of the cornea, is a milky circle about the periphery of the cornea of the aged, and should be regarded as one of the simpler fatty ills, though it has been cited in court as an evidence of insan- ity. While it may be found in cases of un- sound mind, it frequently occurs in the eyes of the perfectly sane. The transparent glassy cornea is nourished by inhibition mostly; hence there is a difficult circulation and the easier occurrence of fatty degeneration when the powers of life begin to fail. "Arcus senilis" is consistent with health, good or otherwise, and is another example of the frequent inadequacy of language to express an exact condition. Atheromatous deposits are masquerades, as they "consist of globules of oil of the most varied sizes, frequently exceedingly minute, mixed with albuminous matter in the form of amorphous masses or flakes and molecules, plates of cholesterine, and gran- ules of carbonate of lime. ,, * They are usually found in arteries, especially so in the aorta, and take the place of the lining membrane and the fibrous and muscular coats. Surely * Mlcrographic Dictionary. IO it is a fatty degeneration, and shows the kin- ship of the latter to calcareous degenerations. All are due to the same cause, retarded circulation by chemical and mechanical means. No one who has seen an athero- matous aorta can deny that the circulation must be retarded and impeded by the marked roughness of the interior of the blood-vessel that thus becomes a secondary cause. The term is derived from a Greek word meaning "groats," or meal; and may be applied to tumors which from the closure of sebaceous glands and the retention of the contents accumulate into masses sometimes as large as a hen's egg; this latter condition is not so much of a masquerade as the term is, when applied to arteries; but if the science of lan- guage exists to apply to things nouns which indicate their nature, then "atheroma" is a signal failure in these days of higher criti- cism. Over forty years ago I was lectured to on Bright's disease of the kidneys, and I have studied it ever since and cannot but believe it is a masquerade of fatty degeneration. Its characters are determined by three signs which must be present as a general rule in the urine, at the same time or in successive periods of time, viz., albumen, casts of kid- ney tubes, fatty epithelia; besides these, free oil, amyloid and catarrhal discharges in the urine, apoplexy of the retina, arcus senilis, glaucoma and puffy eyelids may be present. Rarely is albumen absent; it should be rec- ognized as present when the urine becomes only slightly hazy from the nitric acid and heat test. The idea of this disease being an II inflammation, chronic or acute, of one of more kidney tissues is at least not a good clin- ical one. There is a necrosis and breaking down of parenchymatous substance some- times wonderful to contemplate. Some fifty years ago I attended Warren Academy, Massachusetts, kept by Mr. A. K. Hatha- way, who had Bright's disease. I remember well how he had uraemic coma in school hours — how he would lean back in his arm- chair against the wall, leaving dents in the floor which are visible to-day, I believe; how he would go to sleep during a recitation; how the boys would "catch on" to the situ- ation and begin to break rules of order; how he would wake up suddenly and reduce things to quiet, even if he did shy a Virgil or Herodotus at a roguish boy's head! His case was treated for twenty years by my father, the late Doctor Benjamin Cutter, and among other things he used lamp- wick setons in the loins with much benefit. After death an autopsy revealed both kidneys as empty white lardaceous or tallow shells, less than one-quarter inch thick — the rest of the kid- ney substance was broken down and absent. How any one could live with so little kidney substance was a wonder to all, but the lesson taught was that the lesions were those of fatty degeneration, which softened the neph- ritic structures so that they broke down and disappeared in the urine, leaving the suet- like shell as evidence of the wonderful en- durance of the human frame. When I was a medical student at Harvard, Professor G. C. Shattuck spoke at length on Bright's disease, and employed exquisitely 12 beautiful colored and life-sized French plates for illustrations. The gist of his instruction was fatty degeneration, but the good doctor never gave any clue to really curative treat- ment. It seemed to me then, as it does now, that the magnificent foreign monographs on disease were sadly incomplete. If any one doubts that Bright's disease is a fatty degeneration resort should be had to the morphology of the diseased kidney, and let the histological evidence settle the question. According to our definition of fatty de- generation as due to a retarded and impeded circulation, it is easy to see how it can apply to the kidneys: The circulation in the pa- pillae, the Malpighian tufts, the urinary tubules, must be naturally somewhat im- peded because of their tortuosity; there is constant excretory action and liability to overwork; the tubules are deprived of their epithelia — filled with casts, albuminous, fibrous, or waxy; the cells and tubules are loaded with fat globules or with waxy matter or amyloid, — all of which make things worse by mechanically obstructing the circulation of blood and urine. The loss of albumen from the blood and the retention of urea tend to weaken the system and retard the circulation more. That paralyzing foods have something or much to do with the retarding of the circula- tion and keeping up of the fatty degenera- tion has been often proved to me, and to others, by the results accruing upon the with- holding of and substituting a diet that would not induce these paralyzing effects — a diet that would be assimilated with the minimum 13 expenditure of vital force, and yet furnish the maximum of potential energy to the sys- tem. This history is almost uniformly the disappearance in a shorter or longer time of the albumen, casts, and fatty epithelia, one or all, and by their reappearance when the paralyzing foods are eaten again. To be sure these results are affected by the way in which the patient expends life force. If wasted in work, worry, or pleasure of body, soul, or mind, the abnormal morphologies will be longer in disappearing, or may not entirely disappear; or if they have disap- peared, under the above losses of vital force they will reappear, even if the food is all right, and more rapidly if the food is all wrong. A cheerful disposition aids the cir- culation. Acute Bright's disease I have known to disappear in less than a week by following this line of treatment, but it may require two or three years in chronic cases. Bright's disease of the lungs is another fatty masquerade. Some years ago an emi- nent physician asked me to see a patient with consumption, who had had the best local and metropolitan consultant talent — at the rate of six hundred dollars a month for the latter; she was in bed, feeble, pale, coughing hard, emaciated, with rather vio- lent heart action, and night sweats; physical signs of lesion of left upper third lung front; haemoptysis severe. Sputum with granular and crystalline triple phosphates, giant mu- cous corpuscles filled with gravel; no lung fiber; blood did not show the morphology of consumption. Urine, hyaline with fatty casts 14 of the kidney tubules and fatty epithelia; albumen to one-half the bulk of specimen — thus evidencing fatty degeneration of kidneys as well as of the lungs, for the blood gave no evidence of consumption. On mentioning this to the late Doctor Louis Elsberg, he re- marked the Germans recognized a Bright's disease of the lungs; and he agreed with me in diagnosis on this description. Certainly there is no good reason why lungs should not fattily degenerate as well as any other organ, nor why Americans should not adopt this form of disease in their nosology; had the other medical gentlemen who saw the case not been satisfied with the lung lesions as a sufficient cause they would have ex- plored the urine and got the same striking and positive result ! This is a lesson, and teaches one should never take a chronic case without exploring the morphology and chem- istry of the urine; indeed this is a far better means of daily testing a case than the study of the pulse or temperature. Ruptured or broken heart and fatty heart are not uncommon. Once I was summoned in greatest haste to a lady very ill. She was dead before I arrived at her home, and an autopsy revealed rupture of the left ventricu- lar posterior wall, a pericardium filled with blood, and the muscles undergoing fatty de- generation. With as good reason as exists for cerebral apoplexy this might have been called cardiac apoplexy, for there was the same giving way of the muscles from fatty degeneration, the same extravasation of blood, etc., but with death from loss of blood, not from its pressure, as in some cases of is cerebral haemorrhage. When the heart mus- cle is fatty it is liable to break at any time without unusual effort, as in the case cited. The possibility of producing fatty degenera- tion in phosphorous poisoning in so brief a period as twenty minutes should be remem- bered. Possibly phosphorus interferes with capillary and interstitial nutritive circula- tions, so as to cause degeneration. The changes of nutrition in our bodies are far more rapid than usually surmised. If the chalky, friable textures of dentine can be changed to firm normal fibrous texture in three months' time (as has been reported), why not more rapidly in the softer tissues ? It is a remarkable fact, one I have often noted, that when cases of fatty heart are treated on the principles here laid down, I have seen the normal loudness of cardiac pronunciation reappear in the course of a few weeks, not to say days. Give Nature a chance and she will replace fatty cardiac muscles with healthy ones ! Catalepsy is also, I think, a masquerade, as in my experience it frequently presented all the signs of fatty degeneration — i.e., oil in the blood, fat in leucocytes and albumen, amy- loid casts, and fatty epithelia in urine; also cystine in the blood, this traced to the eating of forbidden yolks of eggs; there was also vaginismus, uterine anteflexion and hyperes- thesia in one case. The fact that local treat- ment — i.e., reposition by uterine sound — with vaginal and intra-uterine iodoformization and general treatment of fatty ills as here laid down, were followed by a cure of catalepsy in three months* time and of the abnormal signs i5 in six months, save fatty epithelia which dis- appeared months later, certainly justifies the mention here of catalepsy as a masquerade of fatty degeneration. About twenty years ago I consulted some eminent Boston oculists as to the cause of cataract, and all agreed it is a " degenera- tion," though of what kind they knew not. I got quite a number of cataractous lenses from ophthalmic surgeons, studied their mor- phology and photographed them, and with the result that I decided it must be due to a fatty degeneration. The microphotographs I took show it. Later mentioning this fact to Baltimore oculists they at once declared our German confreres had arrived at the same conclusion. Accordingly I think it is safe to include cataract among fatty masquerades. If it is natural to expect fatty degeneration in the cornea — i.e., arcus senilis — much more is it to be expected in the crystalline lens which obtains its nourishment through its capsule by inhibition, and is a hyaline, glassy, chitinoid substance to begin with. The dis- location of the crystalline lens by a blow retards and impedes the circulation needed for its nutrition and thus produces traumatic fatty degeneration or cataract. The obliter- ation of the ocular arteries by the deposit of fatty or calcareous matters must impede the circulation in the eye and promote the fatty degeneration. In London, in 1889, I asked Sir Benjamin Ward Richardson whether did not both he and Doctor Weir Mitchell, the former in 1852, the latter in 1861, produce cataract in ten minutes by injecting a tea- spoonful of a saturated watery solutioo of n sugar under the skin of a frog or a guinea- pig. He replied in the affirmative, adding the result was produced "even quicker than that ! " It seems incredible that so generally used a substance as common white sugar should produce cataract in so short a time, but the facts are well authenticated and need no repetition unless in penal physiology on man. Sugar works right in the line of producing fatty degeneration in man, and should not I think be so recklessly and profusely used as now. A teaspoonful of sugar in tea or coffee, taken by a case of Bright's disease where the morphology of the urine has become normal under treatment, must be expected to bring back the abnormal morphology; in any event this is the way to detect such lapses in diet of patients unless they have become firmly established in the way of cure. In my opinion the defective organs of vision common among schoolchildren are due to feeding upon carbo- hydrates in excess. Probably the behests of social ethics in putting sweets to the fore as food have had more to do with the production of lenticular troubles than any other cause. Avoid the use of sugars in excess (better altogether) if you want good crystalline lenses. No " sugar trust" to help bring on fatty ills for me ! Circulation impeded from embolism is an- other fatty ill. Thrombi and emboli are made up of fibrin filaments which are large and massive, in threads curled upon each other by rotation and twisting in the circula- tion of the blood. Often these emboli em- brace within their substance colloid jellies, crystals of oxalate of lime, triple phosphates, etc., which are formed in the blood. Embo i are also made up of white blood-corpuscles in addition, their huddling together in the blood under the microscope is regarded as a sign of embolism (there are emboli of fat). .The conventional idea that thrombi are formed in and on the valves of the heart by some action of these same valves is probably incorrect; more likely that the edges and angles of the valve surfaces present mechan- ical arrangements whereby the clots or thrombi already formed are caught, incor- porated together, and grow; this is rendered more feasible because the blood - stream makes a full stop at the ventricle funda, and is reversed in its direction. During the instant of stasis or stopping an oppor- tunity is given for the adhesive fibrinous masses to be caught on the edges of the valves, especially if the valves are sticky. The valves do not originate the thrombi from the normal subtile, all but invisible, fibrin filaments of the blood, but accrete them from the larger, coarser and more massive abnormal fibrin filaments caused by the action of sour fermenting food in the ali- mentary canal. It is easy to see from the foregoing how the circulation is impeded by emboli, and how the parts supplied by this impeded cir- culation may fattily degenerate; at the same time I do not claim that all the results of embolism are necessarily the result of fatty degeneration, but only that some of them are and must be. By taking in this idea can be understood the importance of regulating the diet in all cases of embolism; and diet and embolism together constitute an American idea destined to honor the practise of medi- cine everywhere and for all time to come, it being one of the most important dicta of this or any age that embolism can be induced at will by feeding fermenting foods, and like- wise that embolism can be cured by feeding on food that does not have acetic acid fer- mentation — food that requires the minimum of vital force for Nature to work with in the functions of the living human body. In this way there will be no growth of excessive alcoholic and vinegary ferments, which are found associated with thrombosis. It is easy to understand how emboli and thrombi arc causal of fatty degeneration, because they mechanically obstruct, retard and impede the functions of all organs whose blood-vessels they block up. Intestinal concretions, many of them at least, are made up of the fat acids accumu- lated from the food eaten — the morphology of the faeces shows crystalline masses of stearine and other fats; also of triple phos- phates, uric acid, urate of soda, stellurine, sugars, oxalate of lime, cystine, pigment matters, etc. Other intestinal concretions are calcareous. In the Museum of the Royal College of Surgeons, London, there is prob- ably the largest collection in the world of intestinal concretions, and some weigh sixty and even ninety pounds. The close relation between fatty and calcareous degenerations makes their association in concretions not strange. A recent patient produced concre- tions from the bowels which had been termed 11 gall-stones," but as they were always voided after the drinking of olive oil, and their struc- ture was made up of minute oil globules, it was evident they were partially digested masses of olive-oil fats. When a patient complains of general de- bility or general weakness and no sign of physical trouble appears but those of fatty degeneration in a mild degree, it seems ra- tional to regard this lesion as the causal one. I have now a case of premature fatty degen- eration of this kind. She is a good patient, but has an almost incontrovertible opinion that nothing will do her good and that she will never be any better; not that she objects to this on philosophic grounds, or is not rec- onciled to the situation. I find as the signs of fatty degeneration clear up this mental debility clears up also; still I have hard work to persuade her to continue in the pre- scribed course to replace the norma! tissues. Of course general debility has other causes, but so long as it masquerades in fatty ills it has a place here, and not to be forgotten. In a recent case where certain physicians signed a certificate that the patient " suffers from post-paralytic dementia which would in- duce homicidal mania," the probate judge was asked to deprive this wealthy man of liberty and property; and both these physi- cians on oath stated that the man's brains were u rotten, Le. 9 softened and decomposed," yet gave no clue to the real cause or essence of the supposed rottenness. The case was compromised. Had it gone on the other side would have testified that while there were 21 evidences of fatty degeneration in the braifl yet there was no dementia nor homicidal mania. Admitting dementia, would it not have been better to have said that the " rot- tenness" came from one of the forms of fatty degeneration, as is usually the case — in other words, would it not have been wiser to have affirmed that the circulation in the brain was impeded and retarded by fat metabolism or by embolism plugging an artery with fibrin- ous concretions, impeding circulation; or that the resulting want of proper nutrition interfered with the functions of the ganglionic nerve centers whereby they would not cere- brate normally nor have the capacity for normal judgment or reason ? As a matter of fact the experts summoned by the defendant, who saw him in an unbiased way, could not agree wjth the above dictum. The hemiplegia of the fight side some twelve years previous, which Nature cured spontaneously, and the hemiplegia of the leftside in 1887, the urinary and blood evidences, were in favor of the lesions being due to fatty degeneration. As to the idea of homicidal mania following hemiplegia, one expert said it was simply ridiculous, as the usual course is the other way. When it comes to be generally known that dementia in many cases is nothing but the result of a fatty degeneration and that fatty degeneration is curable, new light will be thrown on this malady; indeed the treat- ment of this case on the plans here advo- cated resulted in removing the stigmata of fat metabolism, with marked improvement and conference of force, so that he survived the trials of one of the most terrible adversi- 22 ties a sane man can be subjected to. If a brain is unsound we must expect unsoundness of mind, but it makes all the difference in the world if those who treat it do so merely by name instead of elucidating the real cause under which it masquerades. When a case of diphtheria presents albu- men, fatty epithelial and casts in the urine, while it may not be a masquerade such as I have been considering, it comes near enough to it to be treated clinically as such, for the cure is not complete until the signs of fatty degeneration are removed by systemic treat- ment. It may be that the poison of diph- theria does impede, obstruct and make languid functions, and thus becomes a cause of the fat ill; but however this may be, clinically speaking, the treatment should aim to re- move these causes. I venture to predict far better results when this principle is utilized. It is much better to treat diphtheria before- hand by feeding so as to have healthy people on whom diphtheria can have no power. Strictly speaking dropsy is not a disease but a result of obstructed functions, that of circulation for one. So long as the profes- sion employs the term clinically (and the laity think it a most fatal disease, as a rule giving up all hope of help on its professional announcement) just so long when it is pres- ent it must be referred to as a pathological entity at the bedside. It is known as oedema, anasarca, pleurisy, cardiac effusions, etc., acute or chronic according to amount, loca- tion, and time. The whole human body is wrapped in an environment, outside and in- side, of interlaced webs, nets, membranes, *3 and fascia made up of white fibrous tissues, straight, wavy, and curling, serving to keep the soft parts in place; the interstices form areolar spaces mechanically dilatable and expansible, capable of distention by air, called emphysema; by fat, called obesity; by osmosis of blood-serum, called dropsy. From the top of the head to the soles of the feet these areolae communicate with each other, so that puncturing with a knife through the inside cheek mucous membrane to beneath the skin the subject can inflate the whole body sur- face with air; and thus a drowning man could make a life-preserver under the skin; more, this process has been recommended to pro- tect from drowning, though it must be feared the application would be impossible or im- practicable to say the least ! It is well agreed that where there is ob- struction to functions, specifically of the blood circulation, the sanguineous serum is apt to exude and collect in the areolar spaces referred to, especially in the lower parts, by gravity, and where there is fatty degenera- tion. Indeed I cannot recall a case of ascites or anasarca where some evidence of fatty degeneration was not present, which is not strange, considering the fact fatty degenera- tion ills come from retarded and impeded functions, especially of the vascular system. So dropsy and fatty degeneration have the same parentage and hence belong to the same family. There is no good reason for the masquerading of dropsy, especially as it frightens people. From the cases of dropsy I have seen treated as masquerades of fatty ills I feel warranted in formulating the fore- 2 4 going conclusions. I have seen cases of dropsy recover when, humanly speaking, they would have died under conventional treat- ment, and thus dying would have given cause to the panic of mind that exists in the laity when swellings and watery bloats proclaim to all around the distention of the areolar tissues and great cavities specially described by the terrible word " dropsy " I am not sure but fatty degeneration has a good deal to do with dropsies from inflammation, as pleurisy, pericarditis, peri- tonitis, synovitis, etc., coming of course from obstruction by deposits of coagulated lymph, for I have found fatty deposits in pleuritic effusion so copious as to line three-fourths of an inch deep the chest-walls of the left pleura. Also by the plans for treating fatty degeneration I have within two months effec- tually relieved two cases of chronic fistulous pleurisy when it had been proposed to excise a portion of the ribs as a last resort. The following from the pen of the late Professor Joseph Jones, M.D., LL.D., of New Orleans,* evidences that vegetable food will induce dropsy in the yellow-bellied terrapin (Emys serrata), previously carnivorous: Starved for four weeks in a tub of water, then fed forty-two days on purslane (Portulaca oleracea). Blood color intermediate between arterial and ve- nous. Serum changed from orange to light yellow. Cellular tissues permeated by serum. Abdominal and chest cavities contained large amounts of this *" Investigation, Chemical and Physiological, Relative to Certain American Invertebrata," Smith- sonian Contributions to Knowledge. 25 serum. Albumen, fatty and extraction matters, 45.38 in 1000 parts of blood. In another terrapin starved for twenty-eight days, and then kept in water and on purslane eighty-eight days, weight 27.125 grains. Serum was light yellow. Two fluidounces of serum in pleura and areolar tissue along back. Black and brown masses in pancreas contained large yellow composite cells, globules. The only cause that can be assigned for this degen- eration of structure (fatty, crystalline, cancerous) is the character of the food. I have never noticed this in normal terrapin. Other terrapins which had been treated in a similar manner were examined, and the results in every instance corresponded with those detailed as above. In most instances the solid constituents of the blood were less under a vegetable than under an animal diet. The intestines are small in carnivorous and large in frugivorousChelonians. . . Another marked effect in a change of diet was the production of dropsical effusions. Vegetable food in excess then is a chief cause in producing dropsies and fatty ills in man. All the cases of epilepsy I have studied have presented the stigmata of fatty degen- eration at different periods of time, but not all together. Dr. M. G. Wheeler of Chelsea, Massachusetts, tells me that he never had a case of epilepsy without albumen in the urine! Now while albumen alone does not complete a diagnosis it makes it very probable that a careful morphological study would have sup- plied the missing links of diagnosis of fatty degeneration. Again the disappearance of all the signs of fatty degeneration has been followed by the cure of epilepsy, or to put it 26 differently, the epilepsy was not cured before the said signs disappeared; it is probable that they had something causal to do with the cases. At any rate they are good enough clinical clues to unmask a masquerade. Since gall-stones are made up of choles- terine, a fat acid, they come within the same scope. Cholesterine is a normal product of the liver, and should flow off in solution into the small intestines; but when it accumulates in crystalline masses enough to clog the gall- bladder, not to say the gall, mechanical ob- struction is formed to the circulation of bile as well as of blood. Gall-stones must thus cause the fatty degeneration of the gall- bladder which cholecystotomists report as a great trouble in their operations, but this is rather a result than a cause. The cause lies deeper in the same kind of food referred to above and also in not having water enough in the system to keep the saline bodies and fats in solution. Hot water is one of the best promoters of intestinal secretion; it keeps the liver well washed out, removes the gases from fermenting food which paralyze the ali- mentary canal and abdominal viscera. Thick liquids flow less quickly than thin. If, for example, when the bile is inspissated and thickened so that the gall-stones crystallize out, as salt does from watery solution when the water is evaporated, one way to relieve this is to use plenty of distiiied water, which contains no salts and which will thin the bile. Indeed, calculi or gravel of the blood, urine, salivary glands, intestines and other parts may all be rationally treated on the plans of quickening a retarded circulation by the use 27 of hot water. In the words of Doctor A. H. Ferguson, of Chicago:* Let the physician who is in the habit of saying to his patients suffering attack upon attack, " Oh, it is only gall-stone colic," study these changes and then apply the postponement of seeking surgical relief to his own person ! The Golden Rule is aptly befitting. Can the milder forms of cholelithiasis be cured wj^out the knife? ? Why not ? Why does this fatty excremen- titious substance (cholesterine) not go on to its stercoraceous transformation and not form stones in the biliary system of ducts ? Is it a conservative act on the part of Nature to prevent absorption of the constituents of the bile in catarrhal and obstructive conditions of these ducts ? What is the relationship of cholelithiasis and gouty and uric acid diathesis? Not water enough. What local or blood changes predispose to their formation ? Retardation and impeded motion for want of liquidity. What diet, medicine, or hygienic surroundings might prevent them? Beef broiled or roasted and hot water, and medicine sparingly as indicated. Solve that question and the surgeon's knife, needle, or button will happily be less in demand. Belter solve it with distilled water * The Journal of the American Medical Au^cuh Hon, January 19th, 1895. 23 Experimental researches in these directions are very enticing and should bring forth most bene- ficial results. They have already been made, and this whole paper is a reply. Probably never was the term " heart fail- ure" more popular than now, yet it really means little in itself, for death by a bullet through the heart is " heart failure;" or, if the heart were so embarrassed with fibrinous concretions and valvular lesions as to stop, it still would be " heart failure." The title ex- presses a result, not a lesion or a cause. But it is used as a cause, and must be accepted so long as it is used clinically, however much one may dislike its not representing actual conditions or history. From the fact that so many people live on food which is calculated to give fatty degen- eration by impeding the circulation, not only may the heart fail because it cannot over- come the obstacle, while it tries hard to do so, but in most cases it probably is itself weakened by the substitution of fat in place of its muscular tissues. The fat sometimes found in and around the heart, if it does not replace other tissues save by pressing on them, is not to be regarded as a fatty ill, but rather as obesity. In my opinion in many of the cases of so-called conventional " heart failure" the failure is due not only to the fatty ill but to the direct paralyzing influence of the stomachic and intestinal gases acting on a previously weakened or fatty heart. Secre- tary Windom's death at a Delmonico banquet during an after-dinner speech may have been 2 9 one of these cases. So far as I could learn he had symptoms of fatty degeneration be- fore he had eaten this dinner — he used his forces to make a speech before the food was digested; he took away force from its work of digesting food, the stomachic gases acted by osmose, paralyzed the heart, and it failed. Such an accumulation of gases in the stomach is common at two or three o'clock in the morning. Doctor J. Marion Sims and others have died of " heart failure " at about this hour and probably from gas accumulation acting on the heart as just noted. Could draughts of hot water (which have wonderful effect in causing stomachic and intestinal muscular contractions and by starting the "wind") be freely imbibed many of these cases could probably be saved by thus re- moving the immediate cause. Cold water will also expel gas, but not nearly so readily. It is more probable that the heart would not succumb to this depressing influence were it not itself more or less fattily degenerated. Both Secretary Windom and Doctor Sims were at a time of life to have fatty ills. I know Doctor Sims ate things that would pro- duce fatty ills. Striking his breast he once replied to my remonstrances, " I can eat any- thing," So also died that great physician Doctor Louis Elsberg, after I had relieved him of all signs of fatty degeneration, mas- querading as Bright's disease of the kidneys, he acknowledged his cure but insisted upon eating what he liked So also died another friend lately of fatty degeneration though he asked for but would not receive the gospel ot food salvation from his fatty ills. He said, "1 3Q am in the best hospital in the world," yet they gave him the very things to eat which kept his heart fattily enlarged and weakened. Why should fatty heart masquerade as "heart failure?" Why not come out and make names as chemistry and commerce name things? By special invitation Doctor Da Costa lately gave a lecture on weak hearts to the Medical Department of the University of Pennsylvania, at which the Provost, Doc- tor Pepper, and other dignitaries were pres- ent in honor of the occasion. In this lecture the diagnosis of fatty degeneration was based on "elderly gouty subjects, rigid arteries, and flabby tissues, with breathlessness on slight effort, as going up ascents.'' The moment that it is conventionally un- derstood that fatty ills are at the bottom of heart failure, that moment will there be a chance for more rational treatment. This is said notwithstanding Doctor Da Costa's dictum that "in the fatty heart the disease may be palliated, but in the end it is fatal" I speak from personal experience. Now regarding deaths from heat. The New York Tribune of August 14th, 1896, re- ported a policeman found dead. Foul play was feared, but an autopsy showed that Death was due to heat, to which ... he was especially susceptible on account of fatty de- generation of the heart. ... He was fifty-three years old About four months ago he had a slight stroke of paralysis and a fall. . . There were charges pending against him at police headquarters for having been found asleep . . . when he should have been on duty In the same issue there is an account of the sudden death of Henry Van Deremde 3* apothecary manager, found dead by a clerk, who in two hours after was himself found unconscious. The death and the prostra- tion were due to the excessive heat. A policeman found the clerk lying insensible on the floor by the side of the dead body he sat to watch. The coroner and the examin- ing physicians certified that death was from apoplexy superinduced by heat. This puts the case on record as a fatty ill. In the other case the paralysis and im- proper sleep, with the condition of the heart, suffice for the same diagnosis. It is a question, If they had been perfectly healthy would the heat have killed them ? I trow not. Their bodies were rotten with fat metabolism; they succumbed as a decayed post is easily overturned by a blow. There is no doubt that the heat was sudden and ex- cessive. It has been said that more deaths of men and animals were reported in New York during this heated term than ever be- fore. Horses died by the hundreds. If the cases were all like these reported here, then they were masquerades. People eat largely of carbohydrates during hot weather, because they think animal food un- seasonable, a conclusion I doubt. Carbo- hydrates burn up and make heat; ice cream is good to produce warmth; salads easily fer- ment. Lean meats broiled or roasted build up the entire body and give energy to replace the tremendous waste of salts carried off in the greatly increased sweat action. Again, outside of the loss of force by sweating peo- ple are directly prostrated by the action of the excessive heat on the nerve centers. The 32 practise of the writer and corroborator has been to prescribe lean meats broiled or roasted, with boiled potato or toasted bread or rice; no ice water, but cool drinks if de- sired; but hot water quenches thirst best of all things. Hebetude or listlessness and slow move- ments I have seen in fatty ills. One patient who had Bright's disease and was a multi- millionaire said he was so lazy and slow- going that he thought of hiring a man to go behind him and apply a horsewhip when he lagged. This case was entirely relieved of the signs of fatty degeneration, when he said he could " run " his own case, and he did — "run it under ground " in less than two months. I have great sympathy for lazy people. Often if some patients could be lazy they would get well faster, but as I grow older I am more and more convinced that the hebe- tude and laziness in question might be traced to fatty ills, because the sufferers have no reserve power, soon fag out, and are listless for very good reasons— /.*?., the loss of muscle fibers and nerve force from interstitial substi- tution of fat for the nervous and muscular tissues. Haematophilia is another masquerade of fatty degeneration, as is any form of bleeding or haemorrhage due to rottenness of blood- vessels of the capillary and venous kind, which rottenness arises from a substitution of lardaceous, waxy, or steatomatous elements. It may be said also that where the extraction of a tooth threatens life because of profuse haemorrhage, it comes under this head. 33 Hemiplegia, or palsy of one -half of the body, is a common masquerade of fatty de- generation of the muscular coat of the basilar arteries, as before explained. The pressure made by the extravasated blood on the cer- ebral substance exerts by decussation a par- alysis on the opposite side of the body, and sometimes of the same side of the body. It is associated with apoplexy, and is mentioned here by itself because the name is used by the bedside clinically, and is generally re- garded in clinical medicine as a disease by itself. The severity and persistence depend on the topical character of the effusion, as copious or limited in extent. The treatment of hemiplegia rationally comes under the head of fatty degeneration, as I have taught for many years. It is unwise to expect cures while causes go on at work just the same as before the treatment. Hyperaesthesia, again, is another general masquerade. The following case is adduced in evidence: December 30th, 1894, a dentist of New York died at the age of about 71 years; had been ill for more than four years. His blood at the outset had shown oil from beneath skin, and fat in the white corpuscles. Albu- men, fatty epithelia, and kidney casts were occasionally found in the urine, singly and together. When free from albumen, casts, and fatty epithelia, catarrhal discharges would be present in the urine. At times the urine would be normal. It should be said that this urine was carefully studied by me daily for months. By partial treatment the abnormal forms and albumen were mostly removed, and there was an improvement in health, 34 Two and one-half years later he had in the right side of his neck a large chronic diffu- sive abscess which dissected in between the muscles and fascia below the mastoid proc- ess, and afterwards apparently healed. Then the right lymphatic and submaxillary glands became involved The parts under and at the right angle of the lower jaw were swelled, thickened, and hardened. The aspect was so malignant that after aspirating and ob- taining naught but blood a doctor of New York pronounced it cancer. This opinion was sustained by the terrible hyperesthesia of the mouth, tongue, and throat; by a ca- tarrh of the parotid and salivary glands, which was constant, copious, and agonizing; by cachectic appearance; by emaciation; and by this distinguished surgeon's large experi ence with cancerous submaxillary glands, he having extirpated over two hundred. To be sure, crenated pus without cancer-cells was found a few days after over the site of aspi- rated puncture. Later the doctor, in my presence, aspirated thoroughly again. The needles brought forth a bloody fluid, which microscopically showed oil in large and small globules, curling fibrous tissue resembling lung tissue found in sputum, free red and white corpuscles, and fibrin filaments massed in threads and clots. This would appear to have been a fatty ill from the fact that the two aspirations were followed by no malignant changes; that the dense lymphatic swelling would diminish and increase from time to time; that there was never any unpleasant odor; that there was no previous history of cancer; that there was unmistakable evidence of fatty degeneration for years before; that the lymphatic glands could have been inflamed from the dissecting cervical adjacent abscess, as in other cervi- 3S cal abscess histories; that save redness and hyperesthesia the oral cavity and pharynx were normal; that the tongue was soft as silk and its glands were free from induration; that the hyperesthesia was beyond all evi- dence visible to careful inspection; that the gentlest touch of his whiskers, nose, forehead, site of diseased glands, indeed all over the body (he could not bear to have vaselin rubbed on his feet or toes), caused agonizing subjective pains; that he persisted in assert- ing that it was agony for him to swallow (dysphagia) anything, to move his jaw, to speak, etc. From these things the writer could not concur in the diagnosis of cancer, but said that in his opinion it was a case of lymphadenitis with fatty degeneration, in- cluding hyperaesthesia and hypersecretion of the salivary glands. The morphology of the oral discharge, studied very often, showed mucous corpus- cles, bacteria, pavement epithelia, red blood- corpuscles, white blood-corpuscles often with red blood-corpuscles inside of varying sizes, that appeared to come from the diseased lymphatic glands, which I regard as red blood-corpuscle makers — Leptoihrix buccalis, — crystals of the triple phosphate of lime, magnesia and soda, and the aniline blue and emerald green pigment matters that are found in connection with fatty degeneration in the blood especially along with portal ob- struction. The hyperaesthesia was as bad as any uterine hyperaesthesia I ever saw, and this is saying a good deal; it was the great and most prominent symptom in the case. At 36 first I attributed it to the rare overaction of the salivary glands, that weakened them and then translated their neurasthenia to all other parts, as is seen in cases of nervous prostra- tion of uterine origin for example. As fur- ther evidence that this case was a masquerade of fatty degeneration I may add an autopsy revealed the right angle of the jaw standing out and away from the tumors as if there were no tumors; the hardened subdermal lymphatic gland was only half an inch in diameter, cut with a slight grit, under micro- scope showed white fibrous tissue straight and curled, some granules of fat, no elements of cancer form — indeed such had never been found in this case by me. The submaxillary gland appeared like a fatty kidney, somewhat dense in feel to the knife. Under the micro- scope the glandular epithelia were found filled with fat in large and small globes and in granules much the same as the fluid ob- tained by the second aspiration presented; besides, the stroma or parenchyma of the gland was studded with immobile fat gran- ules, while the fluid fat granules presented automobile movements such as are seen in milk. The glandular structure was homo- geneous, save this heterologous tissue. The cells appeared like liver-cells secreting fat. The gland was evidently fattily, not cancer- ously, degenerated. The forefingers of both hands successively introduced through an opening made at the right angle of the lower jaw fully explored the pharynx and base of tongue. No enlarged lingual glands nor lingual induration were found. The larynx was felt to be normal. Arytenoid cartilages, 37 epiglottis, and glottis unaltered. Vomer and nares normal, dome of pharynx normal. The interarytenoid band and the anterior wall of the mouth of the oesophagus were not thick- ened nor abnormally changed. Doctor John A. Cutter verified the examination, and had the case been cancerous the exploration should have shown it. But the question is, how can this terrible hypersesthesia be explained better than by considering it not at all as coming from can- cer ? Cancer does not usually cause pain away from the site, all over the body, nor affect the whole body so that the slightest touch, the gentlest feeling of the pulse at the wrist, causes the severest pain. Should it not rather be considered as a masquerade of fatty degeneration, like angina pectoris and tic douloureux? Surely fatty degeneration was the most constant and prominent element in this case. The patient never fully followed out the treatment for fatty ills: would not live on broiled chopped beef alone; refused nutritive enemata. He refused to eat because of the agony of swallowing and increase of saliva. He complained of choking while eat ing, but never choked nor regurgitated food through the nose or mouth, as is usually the case in stenosis of the throat. His mind was very much on the alert; he noticed all that was going on, as conversation, deeds, ques- tions of domestic ethics, etc. He got but little sleep without medicine — quarter-grain doses of codeia sufficed, and lactucarium served for a time. Towards the last the ab- normal lymphatic and salivary secretions ceased to flow Refusing to eat he died of 38 starvation. Could he have fed like other cases he ought to have got better. At one time my mind was made up to cut through the diseased gland for diagnosis and local stimulation, but was deterred by the opinion he held that it would increase the disease to extirpate it. Had either been done I think it would have proved good for both patient and operator. However, so long as the patient would not come down to strict business in the alimentation needful to re- place fattily degenerated tissues there is no doubt that the fatty ill would have progressed to a deferred death. ■This idea of some neuralgias and hyper- esthesias being due to fatty ills opens a new door to efforts for relief of pain by means of food mainly. Insanity sometimes figures as a cause when it is only a result of fatty degeneration in the cerebrum from retarded and impeded circu- lation, or from embolism. It is not insisted that these alone are causal, but that they sometimes cause insanity — a very broad term, which in law covers all its varieties. Insan- ity from fatty degeneration is evidenced by imbecility, arcus senilis, fluid fat in the blood from beneath the skin, occasional or constant fatty epithelia, casts of the kidney tubes, and albumen. It also may be recognized in ad- dition by the ophthalmoscope revealing fatty changes in the eyeball. Insanity from this cause should be reckoned as a masquerade of fatty ills, since its cause may be unwit- tingly kept at work by food which, thought to be the most wholesome, produces the ills it is designed to evade. 39 One of the most learned and successful physicians, said to have a larger income from his profession than any other American, told another medical man that he diagnosed loco- motor ataxia from the fatty degeneration in the white blood-corpuscles as well as by the rottenness of the red blood-corpuscles, which comes between the rottenness of the red blood-corpuscles of rheumatism and con- sumption. In 1892 I had a case of locomotor ataxia when at one time locomotion was im- possible without help. While it was being re- gained the right arm would be lowered by the torsion of the trunk, so that the hand would nearly come to the ground. Several other physicians saw the case, and all coincided in the diagnosis, and excepting myself made a fatal prognosis. The man was then about thirty years old, and suffered terribly with pains. He was put on strict diet, and after much tribulation was restored to health, so far as locomotion and the common duties of life are concerned, but his handwriting is still ataxic. This case is mentioned because I think I ought to have detected the pre- locomotor ataxic state in him. I did find the fat in leucocytes occasionally, albumen in urine, casts occasionally, and fatty epithelia, and I was on the lookout for kidney destruc- tion. The essence of locomotor ataxia seems to be in a thickening of the fibrous sheaths of the spinal nerves, as well as a degenera- tion of the spinal cord itself. I must say that the fibroid and fatty degenerations are very closely akin; clinically they are alike, to be cured by Nature's being given plenty of force to work with, and mostly by stop- 40 ping causes— to wit, fats and carbohydrates in too great excess. Melancholia means "black bile," which the ar lents recognized as a symptom of a form of insanity, and perhaps truly. Black bile is apt to be inspissated; and thus retarded and impeded in circulation it will take but little to make the normal fatty cells of the liver, complex in its anatomical structure and physiological functions, run over into fatty degeneration — that is, if our definition is correct. The relation of liver troubles to the condition of the nervous system is very close and depressing, as instanced in the sec- tion on general debility: one reason is, if we consider life to be a question of expenditure of vital force, that it must take more force to run the liver when its circulation is sluggish and difficult; then this abstraction of force takes from the other organs — the brain for example, — and the outcome is, there is not force left to run the brain properly. From all this follows the depression of the nerve centers called melancholia. Of course the science of language, notwithstanding the higher critics, is imperfect, and other causes may exist for melancholia; but not being in position to rewrite the English language one must be content with nomenclature as it is, and satisfied with this little hint to try to show the way in which the thought of those who come in contact with this presentation may properly employ their investigations. Look out for fatty degeneration in melan- cholia! Neurasthenia is a term used to denote a nervous prostration whose origin is unknown At or obscure, and from what has been said it may be inferred that fatty degeneration may be a cause; indeed I am convinced I have seen neurasthenic cases of fatty degeneration, and that there is always a cause for neuras- thenia, discovered or not. The kinship of male neurasthenia that arises from a peculiar urinary catarrh, which often disappears and is replaced by fatty epithelia, casts of kidney tubes, and albumen in the urine (one or both), is I think very close, and makes it proper for neurasthenia to be classed as sometimes a masquerade of fatty degenera- tion. At any rate it is worth studying in this practical connection. Paraplegia is a variety of hemorrhagic apoplexy where both sides of the body lose their motor, and sometimes sensory, func- tions because of the greatness of the pres- sure on the brain; it is mentioned because it is a masquerade of fatty degeneration not to be overlooked. It is due to a more extensive rupture of the cerebral arteries than usual, because the normal strength of these arteries has been weakened through the substitution of muscular and sometimes fibrous tissues by oleic acid, palmitic acid, and cholesterine, etc., which substances have no textile strength to resist centrifugal forces as they do centri- petal forces when blood is forced and buried in the outside soft cerebral parenchyma. Paraplegia is mostly a question of strength of structural elements whose nature is softer than normal. From this point of view it is wonderful paraplegia does not oftener occur. Paresis means general paralysis of motion (and not of sensation), more or less complete; 4* if complete there would be no paresis, be- cause death would at once follow from heart paralysis. It is rather a paralysis resulting from the degeneration of the tissues of the body, not confined to the muscles, but em- bracing the structural elements of the nerves, fibrous tissues, etc. It is most likely to be fatty in some one or more of its forms. There are partial responses to stimuli of the sensory or motor nerves, but there is also a relaxation which shows that the neurotic sys- tem is paretic. Instead of masquerading as a separate disease it should appear as only one of the manifestations of fatty ills which demand an interstitial nutritive treatment whereby Nature can and will restore the de- generation, entirely remove the fat intruders, and thus cure on common-sense principles. Pernicious anaemia is believed in America to arise from terminal arterial vessels fattily degenerated, leading to a pernicious loss of blood discs so grave and severe as to be fatal. The main points are: It usually occurs in the last stages of fatty ills: Both voluntary and involuntary muscles are involved: The parent cells in the blood-glands are degen- erated: Blood is not organized in normal quantities: Patients grow bloodless and weakened. The treatment should be that of the fatty ills. After more than thirty years of considera- tion, puerperal convulsions seem to me to be due to an acute fatty degeneration of the kidneys, placenta, etc. I am well aware that others do not entertain this view, but how can one read the signs and symptoms other- Wise? Let me relate a case: 43 In 1880 a young wife was pregnant with her first child. At her marriage I met her; she was then thin, slim, apparently well. I saw little of her before she was far advanced in pregnancy, when her appearance was so changed that I hardly knew her; a lady very stout, obese, and bloated, with eyelids (Ede- matous and face waxy. She made little complaint. She had lived a life of no work, eating all the "good things" she could find, boarding with her mother and having an easy time. The urine contained plenty of hyaline and fatty cylinders from the kidney-tubules, abundant fatty and deformed epithelia, and was two-thirds in bulk albuminous. I gave her simple remedies and arranged for sum- mons when her labor should begin. It hap- pened that night. She got through well. The babe weighed three and one-half pounds. The placenta was one-third degenerated into what appeared to be ovoid and obovoid masses, possibly syphilitic or cancerous even. I had not met with such appearances before, nor have I since. The clinical morphology of the placenta showed the whitish, hard masses to be made up of plates of cholester- ine, as a rule longitudinally parallel with the long axis of the placental tufts. When the babe was one day old, and the mother doing well, a steam fire-engine, for practise, was attached to a hydrant in front of the house where she was and set going in spite of the protestations of those concerned in the care of this patient. The shrill sound of the whistle blown in defiance sent her into convulsions, which lasted eighteen hours, consciousness not returning until two days later. She was treated by ether ancesthesia, calomel and jalap purging, and beef essence ad libitum, combined with very careful watching^ and nursing. In less than one week the albumen and the casts disappeared, and she gradually convalesced into a good recovery, though the 44 left side of the face was paralyzed for some months afterwards. At the present time there is a slight facial paralysis. Otherwise she has developed into a woman of splendid capaci- ties and mental abilities. To show that Bright's disease of the kid- neys has convulsions as a symptom I can refer to a case of a man who also came near dying in like convulsions, but survived some months without convulsions on the diet which is em- ployed to arrest fatty degeneration. No doubt there was ursemic poisoning in these cases; still the essence of the disease was the fatty degeneration, as manifested by the physical exploration. How can the kidneys properly eliminate urea when they are choked and impeded by fatty metabolism ? If motherhood would feed on two-thirds animal and one-third vegetable food by bulk I think there would never be any puerperal convulsions from fatty degeneration. This is said advisedly, as in the case alluded to two other children were born afterward to the same mother living on this diet; no puerperal fatty ills complicated these second and third labors. Those who saw the frozen sections of pregnant women's trunks, and witnessed the enormous abdominal distention and the great displacements of the thoracic and ventral viscera, at Berlin Medical Congress in 1890, cannot but believe that the circulations are hampered and impeded Thus is furnished one of the great prerequisites for tatty de- generation. The wonder is it does not occur oftener, when so many women live to eat, not eat to live. 45 The case cited had insufficient exercise, which it will be remembered is enough to spoil even horses in a few months by the degeneration in question. Albuminuric retinitis is a form of fatty degeneration. Lately I was shocked to learn from a most eminent American maker of telescopes that his wife, whom I had met apparently well a year or two previous, had died of Bright's disease of the kidneys. This was undiscovered until just before death, though her medical attendants (he said) had repeatedly examined the urine and found no albumen. — I wonder if they looked for fatty epithelia or cylinders. The detection was made by the ophthalmoscopist. Here is a lesson for the profession ! For this want of diagnosis the bereaved husband was so bitter on medical men that I thought he meant me in particular; so I furnished him with evi- dence such as I am giving here to show that the medical profession was not at the low level he claimed. I did not assert that other medical men knew less than myself, but I did insist that some medical men knew how to detect and treat the disease in question, and that I would not calmly submit to his unsustained assertions. In evidence let me quote from the Medical Times and Register* as to retinitis being a fatty degeneration: (Edema of the lower eyelid; the upper has a less lax histological structure, — a very characteristic symptom of Bright's disease: Dim vision with fading and receding pupil from iris muscles being weak: * February 24th, 1894, 46 Pupils dilated from weak iris muscles: Michael says that cataract and albuminuria are simultaneous results in the eyes and kidneys from the same general cause — arterio-sclerosis.* Doctor L. Webster Fox says: "We have the forerunner of non-albuminous Bright's disease in retinal haemorrhage; there is sclerosis of blood- vessels as shown by whiteness:" Also says, "The capillaries are involved in like changes: Signs of albuminuria retinitis; optic nerve swollen, vascular walls about blood-vessels more or less white." Forster thinks the disease is due to alteration of the blood which causes degeneration (fatty) on the blood-vessels' walls. f Charles Theodore, Duke of Bavaria, found hyaline (fatty) degeneration and endoarteritis in retinal arteries. The middle and internal coats are thickened, and the caliber less- ened (i.e., circulation impeded); small fatty gran- ulations sometimes filled the small arteries. Fibers of Miller late in disease show traces of fatty degeneration, and are full of granulation or small drops of fat. From what has been said it can be readily seen that rupture of muscle is a masquerade of fatty metabolism. Fat may replace mus- cular fiber from high feeding without due exercise; from ligatures about said muscles; from the circulation being impeded by the gases of fermentation in the alimentary canal. It is easy to see how such weakened muscles may rupture from violent efforts; but muscles may rupture while doing life's legitimate nor- mal work, — in other words, muscles may be so weakened in substance as to tear themselves apart in normal efforts. It is easy to see how powerful muscular force ruptures the muscles themselves, even when they are not *I add, which is due to food.— E. C. t Wrong.— E. C. 47 fattily degenerated, as in the case of our Saviour at his crucifixion. He was in per- fect health, yet medical men who have critically studied the immediate cause of his death are well satisfied that his heart was literally ruptured by anguish. Christ's death being so much earlier than ordinary in cruci- fixion caused Pilate to wonder why he died so soon. Rupture of uterus might come under rup- ture of muscles, but as it constitutes one of the gravest accidents of obstetrics it deserves a separate mention. The following were the prominent features in a case of mine: Irish woman aged 28 years; pelvis con- tracted; previous labor, one, terminated after several days by Doctor Benjamin Cutter by embryulcia. In i860, July 7th, 9 p.m., I found her with strong pains; os fully dilated; occiput to the right acetabulum; head in superior strait whose anteroposterior diam- eter was about three inches. For several hours the labor was severe; no headway. Forceps refused at first; but just as they were about to be resorted to she urged man- ual help. Passing hand still further, to my horror I found a free and open space in which were felt folds of the peritoneal sur- faces, the wedge shape of the liver, the feet and hands of the child, the placenta, etc. The uterus was firmly contracted and lying to one side. It was the first time my hand was ever inside the abdominal cavity of a living human being ! Things were so critical that I at once turned and delivered by the feet. I asked for assistance, but the patient and friends insisted on my carrying the case through alone. 48 After delivery the patient had a pinched face and Hippocratic countenance; no pulse in wrists; extremities cold; sighing respira- tion; great distress in abdomen. Was con- stantly begging and entreating to be allowed to sit up. Great restlessness, constant vomit- ting, and intense thirst. Freely gave tincture of capsicum, ergot, Hoffman's anodyne, gin, and tincture of opium. From these some im- pression was made on the pulse and symp- toms. Abdomen very tender to the touch and very painful to patient. Death followed twenty-nine hours after delivery. The rup- ture involved the lower part of the uterus and the upper part of the vagina, posteriorly. Fortunately, this condition is exceedingly rare; the case is here given as a necessary clinical contribution. If I could control the diet of obstetrical cases, it would be two-thirds animal and one- third vegetable food by bulk. While I know that this plan gives fine normal developments in the epithelial cells of the mammary gland, I feel quite sure that it would prevent abnor- mal fatty degeneration. To show that this question occupies the thought of obstetricians I quote from the University Medical Maga- Regarding fatty degeneration of the uterus during pregnancy L. M. Bossif found this in active process in three human uteri, one removed at the eighth month of pregnancy and the other two at term. He inquires whether this is the physiological condition, and if so whether it may not explain the * March, 1897. \Annati di Obstetrica e Gynecologica, December, 189b. 49 wonderful rapidity with which involution of the uterus after labor normally takes place. It may be asked further whether in this fatty degeneration there exists an explanation of some cases of inertia uteri in labor. Bossi has attempted to investigate the subject by the experiments on animals of tying the uterine blood-vessels, but does not regard the results as applicable to the human uterus. I suppose most clinicians agree that scar- let fever without the stigmata of fatty degen- eration is shorn of many of its perils. The signs of fatty metabolism and scarlet fever simply tally. Both may have albumen, fatty epithelia, and cylinders in urine, and dropsy in all forms; also diseased epithelia in urine, which have much to do with the cause of fever. I once saw a case where severe scar- latina occurred at the age of six years, but who died at the age of thirty-two, with ex- tensive fatty metabolism in heart, kidneys, liver, and brain, as the autopsy showed; be- sides, three years before death she had puer- peral convulsions under my father's care. Professor D. Humphreys Storer, of Boston, saw her in consultation; he then taught that these convulsions were due to fat metabolism, and certainly she had all the signs of it. She recovered. A year and a half later she had facial paralysis on the left side. Finally her death came from a second haemorrhage into the same ventricle, for I found it completely filled with a fresh clot of blood. I also found the fibrous remains of the first causal effusion inside the left lateral ventricle of the brain. The kidneys had the development of a child of six years. She never was well after this fever, and would probably have not lived to 5° maturity had she not persistently kept out of doors during the day. The work of the kidneys is vicarious with the skin, and when invaded by scarlatina the result is these organs are overwhelmed, their functions rendered languid or impeded, hence fatty transformation. Surely the rashes of scarlet fever demonstrate that the skin is congested, its capillaries dilated, and its cir- culation impeded; and as the skin is the largest gland in the body, with twenty-five miles of sweat ducts, this dermal retardation and impeding must be an element in fatty degeneration when it occurs in this malady. Sclerosis is a term employed when the de- generation is of a denser substance than the tissues it replaces; its nature is twofold, fatty and fibrous. Regarding the former — as has been said before — when cholesterine replaces tissue it is apt to be accompanied by lime deposits which give the artery affected a feel like stone; of course fatty degeneration must follow, even if it has not preceded such sclero- sis. The mere obstruction to the circulation, for example, caused by the cholesterine is a sufficient cause. Fibrous thickening or ab- normal increase of white or curling fibrous tissue form another kind of sclerosis. This tissue is laid down in a weakened condition and possesses the first elemental cause of fatty degeneration, /. LL.D. Gaillard's Med. Journal, New York, Febru- ary, 1881. Food and Tubercle. International Med. Congress, Berlin, 1890. Count Rumford as Cook. Woburn Journal, May 30th, 1890. Food as a Medicine in Typhoid Fever and in Laryngeal Growth. Middlesex S. Dis. Med. Society, Massachusetts, May, 1877. Food in Nervous Affections. Journal of Am. Med. Association, 1888. Food in Motherhood. Book. D. Stott, 370 Oxford street, London, January, 1890. Out of print. Heart Disease and Feeding. Open letter to W. T# Gardner, M.D., LL.D., Glasgow. Albany Medical Annals, September, 1888. PARTIAL BIBLIOGRAPHY. 179 Vinegar and Vinegar Yeast. Times and Register, Philadelphia, July, 1889. Diet List for Lactation. Michigan Med. News, August, 1880. Feeding of Nursing Children. Virginia Med. Monthly, August, 1880. Food in Agalaxia. American Journal of Obstetrics, New York, April, 1878, Candy. Boston Journal of Chemistry, April, 1876. Diseased Teeth. Youth's Companion, Boston, De- cember, 1886. Teeth and Flour. American Journal of Dental Science, November, 1878. Is Flour our Proper Food? Trans. New Hampshire State Med. Society, 1875; The Doctor, New York, January and February, 1890. Does the Use of Flour Promote the Decay of Teeth? Boston Journal of Chemistry, December, 1874. Does the Use of Flour Promote Affections of the Nervous System? Boston Journal of Chemistry, Feb- ruary, 1875. Asthenic Disease and Flour. Boston Journal of Chemistry, April, 1873. Examination of Flour. Boston Sunday Herald, December 5th, 1880. Whole Wheat Cleaned. Popular Science News, Boston, January-February, 1888; Home Missionary; S. Sc, London, June, 1888. Sugar. Annals of Hygiene, Philadelphia, April, 1888. Butter. Michigan Med. News, June 25th, 1881. List of Food Stuffs under the Microscope Cincin- nati Medical News, March, 1881. Highly Important and Extensively Advertised Cereal Foods under the Microscope. Twenty-eight cuts. Am. Med. Weekly, January 7th, 1882, edition 260,000; Scientific American; also newspapers. Flour. Gaillard's Med. Journal, 1882. Tubercle Parasite. Am. Med. Weekly, May, 18S2; Christian Advocate, June 1st, 1882. A New Clinical Microscope. Boston Journal of Chemistry, April, 1869. Amoeboid Movements of the White Blood Corpus- cle. Boston Journal of Chemistry, June, 1S76. l8o PARTIAL BIBLIOGRAPHY. Tolles' One-Seventy-fifth Inch Objective: its His- tory, Uses, and Construction. Am. Journal of Arts and Sciences, New Haven, August, 1879; Scientific Am. Supplement. Translated into French and pub- lished in Journal de Micrographie, Paris, 1879. Primer of the Clinical Microscope. Virginia Med. Monthly, August and September, 1879. Pamphlet. A New Physical Sign of the Pretubercular State. 1877. Illustrated. Morphology of Syphilitic Blood. Am. Journal of Dental Science, October, 1879. Reprint. Throat Syphilis and Tubercle according to Salis- bury. Archives of Laryngology, New York, Decem- ber, 1880. Use of the Microscope in Consumption. Diagnosis of Necrosis and Disintegration. First paper. Journal of Microscopy, Phin's, September, 1881. Use of Microscope in Consumption. Second paper. Necrosis of Lung. Differential Diagnosis. Am. Journal of Microscopy, Phin's, 1882. Crypta Syphilitica. Monographia Syphilitica. September, 1888. On the Morphology of Rheumatic Blood. Phila- delphia Med. Times, February, 1889. Under what Circumstances Do the Usual Signs Fur- nished by Auscultation and Percussion Prove Falla- cious? Boylston gold medal prize essay, 1857. A New Resting and Invalid Chair. Chicago Med. Journal and Examiner, September, 1877. The Relations of Medicine and Music. Circular of Information, U. S. Bureau of Education, Washing- ton, D. C, 1886. The Relation of Medicine and Music. Read to Society of Sc, Letters, and Art, London, November, 1880. Published 1891. Relations of Music and Medicine. Rewritten. Albany Medical Annals, November, 1888. Music and Athletics. Journal S. Sc, London, No- vember 20th, 1889. Food and Music. Dietetic Gazette, January, 1890. The Voice in Speech, Song, and Whisper. Voice, New York, July, 1890; New York State Music Teach- ers' Association Transactions, 1890. Report on Flour and Decayed Teeth. Mass. State Board of Health, 1875. APPENDICES. APPENDIX A. "An Invalid's Chair." {Extract from the English Mechanic and World of Science, London , Jan. Jth, 1876.) "The New Chair invented by Dr. Ephraim CuTTfcR, and represented in the annexed illustration, [p. 182], involves some novel features which are not to be found in similar devices. The back of the chair, the seat, and the leg portion have each an independent motion in vertical planes, corresponding to the motions of the great natural divisions of the human body. The arrangements allow of the variety of changes which are found existing in the human body in a state of perfect rest. Having made the adjustments, the whole series of inclined planes can be made to revolve about a common centre, and the weight of the body can be thrown from one division on to another, or distributed equally over the entire body surface. At the same time the chair allows of the motion of the hip and knee joints. An endless screw gear secures the equable, firm, and certain movement, with no fear of detach- ment or breakage under ordinary usage. The feet may be easily raised higher than the head, thus allow- ing the return of the blood from the extremities by reversing the hydrostatic pressure of the column of blood in the veins — a very desirable arrangement in cases of cardiac disease." See pages 112, 113, 114. 181 l82 APPENDIX B. Varieties of Sugar. g s= glucose group, s = saccharose group. Name and Group. arabinose, g dambose, g dextrose, g eucalyn, g galactose, g inosite, g lactose, s levulose, g maltose, s meligitose, s melitose, s mycose (ergot sugar) saccharose, s scylite, g sorbin, g synanthrose, s trehalose, s Origin. Gum arabic Dambonie Vegetables, honey, etc. Melitose Milk-sugar Flesh, etc. Milk Fruits, etc. Malt Larch-manna Australian manna Fungi, as ergot Sugar-cane, beet, etc. Fish, etc. Mountain ash berries Dahlia and other tubers Terhala manna (From Standard Dictionary.) 183 APPENDIX C. Doctors' Offices in Business Buildings. Equitable Building, 120 Broadway, New York, February ist, 1896. To the Editor of the New York Medical Journal: Sir: Your comment in the current number of the Journal, on physicians occupying office buildings, prompts me to write that for over three years my office for consulting has been in the Equitable Building, and that my experience justifies me in commending the action of the Metropolitan Life Insurance Company in preparing to rent to reputable physicians. One of the advantages is that of removing one's work in great part from contact with one's family; women like this es- pecially, as there is an impersonality about a great office building nowhere else obtainable; moreover, the physician obtains quarters in a splendidly fitted build- ing, with surroundings equal to those of many a palace. In the great insurance company buildings, the woodwork alone is of the highest order. It should be saving of money, as one can live in a more modest home, and not as his business increases swell out into larger establishment, such "swelling" being the downfall of many medical men financially. There is an ethical consideration : the ' ' great " physician with an immense income does not do as good medical work as the man that earns much less, other things being equal as to education and natural ability. The laity think the opposite, and if they find a physician's office crammed full of patients, he is their man. Now, the coming practice of medicine is to be in large part the more careful handling of chronic diseases; such handling takes time, and as soon as the laity realize that a physician will do better work who manages but a few patients, the better it will be for all concerned. The aggregation of doctors in a first-class office building will tend toward this de- sirable end as placing all on a common level. Medical men work altogether too long each day, and live altogether too short lives. To go home from the 184 ts$ office and know that a great part of the day's work is done, and that one will not have to labor away into the evening, is a fine thing. Educate the people to know that, except in case of emergency, which we are always prepared for, the office work is to be done at certain hours in one place, and the doctor will have more rest and time to see his family, bring up his children in the way they should go, and receive the admonitions of his wife. Other advantages are a fireproof and carefully watched building, and good attendance as to cleaning. The only objection is the necessity of two addresses. It seems to me that, as the Metropolitan Company are fitting up for a large number of doctors, special arrangements could be made whereby telegrams re- ceived after office hours would be forwarded by the superintendent to the homes of the persons addressed. I wish to say one word as to so-called waste of money in the great insurance company buildings. From my personal observation down -town, I believe that the insurance companies have invested the money of the policy holders most wisely; " the best is the cheapest "; they have used the best as to material, and have not hesitated to get enough light and air. This cannot be said of some buildings put up by rich men for investment ; they have scrimped so as to ma- terial and space that their investment, I think, does not pay as it otherwise would. Finally, all hail the time when medical men will not be in contact with patients more than eight hours a day! John A. Cutter, M.D. (From the Ntw York Medical Journal, February 22d, 1896.) INDEX. Abnormal fatty ills, 3, 3a Acute fatty degeneration, 3a Adipocere, 2 Air, 102, 103 Albumen in urine, 66, 67 Albuminuria retinitis, a masquerade, 45, 46 Alcohol, avoid, 82, 83 Alcoholic and acid yeasts in all animal and vegetable foods, 84 Alcoholism, a masquerade, 4 acute results of, 4 cases of, 151, 152 Althaus, 120 Amaurosis, a masquerade, 4 case of, 140, 141 American Electro-Therapeutic Association, 108 Neurological Association, 55 Amyloid, a masquerade, 5 bodies in brain, 1 in urine, 70, 71 Anaemia, pernicious, a masquerade, 42 Angina pectoris, a masquerade, 5, 6, 7 pectoris, case of, 141, 142 Aphasia, a masquerade, 7 Apoplexy, a masquerade, 7, 8 and hemiplegia, 33 and paraplegia, 41 cases of, 149, 150 death from, 142 retinal, a masquerade, 8, 9 with Bright's disease, 49 Arcus senilis, a masquerade, 9 Arthritis deformans, case of, 157 Asthma, 87 cases of, 145, 147 Atheroma, a masquerade, 9, 10 Avoid fatty foods, 81, 82 yeasts in all animal and vegetable foods, 84 Basedow's Disease, a masquerade, 52, 53 Beef, a quickening food, 87, 88 187 l88 INDEX. Berlin Medical Congress, 44 Billings, Judge, 97 Blaine, James G., 130 Bleeding, excessive, a masquerade, 32 Boston, 140 Brain, softening of, a masquerade, 54, 55 Bright's disease, 4, 5 disease, acute, 13 ^ disease and convulsions, 44 disease, cases of, 140, 141, 145-166 disease caused by shock, 53 disease of kidneys and albuminuric retinitis, 45, 46 disease of the kidneys, a masquerade, 10, 11, 12, 13, 29 disease of the lungs, 166, 167 disease of the lungs, a masquerade, 13, 14 disease in scarlet fever, a masquerade, 49, 50 British Medical Association, 96 Butter, melted, to be studied, 64 Breasts, epithelia of, 1 Calculi, 87 kidney, 106, 107 Cancer and fatty degeneration, a masquerade, 50, 51 cases of, 153, 154 Canon Harford, 129, 130 Carbonic acid causing death, 80, 81, 115 Cases, 140-172 Casts of kidney tubes in urine, 68--70 pseudo, in urine, 70 Catalepsy, a masquerade, 15, 16 cases of, 142, 143 Cataract, 142 a masquerade, 16, 17 Catarrh, urinary, 72-75 Causation, see Definitions Celsus, 135 Chair, Cutter, 112-114, Appendix A Charles Theodore, Duke of Bavaria, 46 Cbickering, Rev. Dr. J. C, 140, 141 Chenopodium ambrosioides, 52 Christ's death due to heart rupture, 47 Circulation to be quickened, 84-88 Clarke, President, 107 Climate, 91, 92 Clinician must understand micrography, 82 Codman, Dr. B. S., 53 Codman & Shurtleff, 53 Colds, treatment of, 86 Concretion, intestinal, a masquerade, 19, 20 Conference of force, 95-101 INDEX. 189 Confidence lost, 95 Conservation of vital force, 88-90 Constipation, 132, 133 Consumption, cases of, 156, 157, 164 of the bowels, case of, 149 Convulsions in Bright's disease, 44 puerperal, 42-44 puerperal, a masquerade, 42-45 Cooke, Prof. JosiahP,, 65, 108 Corpora lutea, 1 Courage, 92, 93 Crypta syphilitica, 56, 57 Cutter, Dr. Benjamin, 11 E. P., 124 Cystinsemia, 15 Da Costa, Dr., 30 Dana, Dr. C. L., 55 David, King, 129 Davy, Sir Humphry, 98 Death from heat, a masquerade, 30-32 Debility, general, a masquerade, 20 Definitions, ix-xiv Delmonico banquet, 28 Dementia, a masquerade, 20-22 D'Etoille, Terry, 120 Diabetes, cases of, 148, 164, 165 Diagnosis, 61-79 Dieta literarum, 129 Diphtheria, a masquerade, 22 Diseases due to old age, 1 Doctors' offices in business buildings, Appendix C Dogiel, Professor, 128 Dress, 108-111 Dropsy, a masquerade, 22-25 Electricity, 118-125 Elsberg, Dr. Louis, 14, 29, 119, 120, 150 Embolism, a masquerade, 17-19 Epilepsy, a masquerade, 25, 26 cases of, 143-145 Epithelia of breasts, 1 of sebaceous glands, 1 Epithelial cells of kidneys, 1 Exercise, 90, 91 Eye disease, a masquerade, 4, 5 cases of, 140, 141 fatty tumor of, 174 Facial neuralgia, 6 neuralgia, a masquerade, 57 I90 INDEX. Facial neuralgia, case of, 173 Faith in God, 95 Fat, free subdermal, in blood specimens, 61, 62, 63 in white blood corpuscle, 63, 64 office of, in healthy body, 2 omental, 2 thrombi and emboli of, 64 Fatty degeneration, acute, 36 degeneration a preventive process, 6o, degeneration, diagnosis of, 61-79 degeneration in lean people, 2 epithelia in urine, 67, 68, 75 foods, avoid, 81, 82 heart, 3 ills, abnormal, and recognized as fatty degenera- tion, 3, 3a ills, masquerades, 30-60 liver, 3 Ferguson, Dr. A. H., 27 Fibres of Miiller, 46 Fibroid and sclerotic degeneration, 84 Field, Prof. H. M., 121 Forster, 46 Fox, Dr. L. Webster, 46 Fruits must be fresh, 83, 84 Gall stones, a masquerade, 26-28 Galvanism, uterine fibroids, 123 Gangrene, senile, a masquerade, 51, 52 Garfield, President, 113 Gases from meat indigestion, 84 General debility, a masquerade, 20 hyperesthesia, a masquerade, 33-38 Gettysburg, 92 Glaucoma, case of, 14 Gout, 87 Graafian follicles, 1 Grant, General, 92 Guy's hospital, 98 HiEMATOPHlLiA, a masquerade, 32, cases of, 152, 171 Harvard, 11 Hathaway, Mr. A. K., 11 Haven of health, 129 Heart diseases, cases of, 141, 142, 153, 161, 162, 169, 170 failure, a masquerade, 28-30 fatty, 3 ruptured or broken, a masquerade, 14, 15 INDEX. 191 Heart, strengthen, 111-116 Heat, 101, 102 death, a masquerade, 30-32 Hebetude, a masquerade, 32 cases of, 154, 167, 168 Heck, Dr., 55 Hemiplegia, 21 a masquerade, 33 Heubner, Prof., 55 Hoffman's anodyne, 114 Holcombe, Dr. W. F., 166 Hospital, The, 91 Hot water, 84-87 Hyperesthesia, general, a masquerade, 33-38 Ideas, stimulus of, 92, 93 Insanity and dementia, 20-22 a masquerade, 38 Intestinal concretions, a masquerade, 19, 20 Jones, Prof. Joseph, xii, 24, 58, 119 Dr. McNaughton, 4 Journal American Medical Association, 27 der Praticien, 52 Kazan, Russia, 128 Kidneys, epithelial cells of, 1 Kidneys (see Bright's disease) Kimball, Dr. Oilman, 136 Rev. Peter, 127 Laziness, a masquerade, 32 Lean people suffer from fatty degeneration, 2 Liegeois, M., 52, 53, 55 Life a question of expenditure of vital force, 89 Light, 117, 118 Listlessness, a masquerade, 32 Liver, fatty, 3 Locomotor ataxia, a masquerade, 39, 40 ataxia, cases of, 146, 157, 162, 163, 168 ataxia (see Sclerosis), 59 Lungs, Bright's disease of, a masquerade, 13, 14 Management, 134, 135 Marcy, Dr. II. O.. x Maryland Medical Journal, 55, 56 Masquerades of fatty ills, 30-60 Massachusetts Agricultural College, 107 Massage, good done by conference of force, 99-IOI Medical club at Vienna, 55 Times and Register, 45 192 INDEX. Medicine, 112 Medicines, 131, 132 Melancholia, a masquerade, 4 Michael, 46 Micrographic Dictionary, 3, 9, 61 Mliller, fibres of, 46 Milk, to be studied, 64 Mitchell, Dr. S. Weir, 4, 16, 142 Morphology of puerperal discharge, I of the urine, 65-70 Motherhood, food in, 44 Muscle, rupture of, a masquerade, 46, 47 Muscular fibre, morphology of, 64 Museum, Royal College of Surgeons, London, 19 Music, 126-131 Nature cures, 79, 135-139 Neuralgia due to fatty ills, 38 facial, 6 facial, a masquerade, 57 facial, case of, 173 Neurasthenia, a masquerade, 40, 41 cases of, 146, 148, 149, 163, 164 (see Catarrh, urinary) Newman, Dr. Robert, 119 New York Medical Journal, 3a York Tribune, 30 Ninth Massachusetts Battery, 92 Normal fatty degeneration, 1 Obesity, 2, 3 Oil, free, in urine, 72 to be studied, 64 Osier, Prof., 139, 140 Ovarian subinvolution, 1 Oyster, raw, causing acute fatty degeneration, 3a Palsy, shaking, a masquerade, 52, 53 Paralysis agitans, a masquerade, 52, 53 Paraplegia, a masquerade, 41 Paresis, a masquerade, 41, 42 Pepper, Dr., 30 Pernicious anaemia, a masquerade, 42 Physical signs, 75-79 Pigment matter in blood morphology, 64, 65 Pilate, 47 Pitt, the elder, 96 Premature old age, 3 Preservative process in fatty degeneration, 60, 61 Protoplasm, force of, 106, 107 Pseudo-casts in urine, 70 INDEX. 193 Puerperal convulsions, a masquerade, 42-45 discharge, morphology of, 1 Rest, 88-90 Retinal apoplexy, a masquerade, 8, 9 apoplexy, case of, 166 Retinitis, albuminuric, a masquerade, 45, 46 Rheumatism, 87 Richardson, Sir B. W., II, 141, 142 Robbins, Dr. Henry A., 55, 56 Roberts, 139, 140 Rosenstein, 139, 140 Rottenburger, John, 129 Royal College Surgeons (London) Museum, 19 Rumford, Count, 76 Ruptured heart, a masquerade, 14, 15 Rupture of muscle, a masquerade, 46, 47 of uterus, a masquerade, 47-49 Saviour, 96 Sayre, Prof. Lewis A., 109, 112 Scarlet fever, 104 fever and Bright's disease, case of, 159 fever with Bright's disease, making a masque- rade, 49, 50 Sclerosis, a masquerade, 50 Sebaceous glands, epithelia of, 1 Seidlitz powder causing death, 80 Senile gangrene, a masquerade, 51, 52 Shaking palsy, a masquerade, 52, 53 Shattuck, Prof. G. C, 11 Shock, a masquerade, 53, 54 Sims, Dr. J. Marion, 29 Skin, hygiene of, 103-108 Small-pox with fatty degeneration, a masquerade, 54 Smithsonian contribution to knowledge, 24 Softening of brain, a masquerade, 54, 55 Special and particular treatment, with illustrative cases, 140-175 St. Cecilia's Guild, 130 Storer, Dr. D. Humphreys, 49 Strengthen the heart, 111-116 Subinvolution, ovarian, 1 uterine, 1 Sugars, list of, Appendix B Summer heat, proper food in time of, 31, 32 Syphilis, a masquerade, 55-57 Tarchanoff, Prof., 126 Thrombi of fat, 64 194 INDEX. Thrombosis, a masquerade, 17-19 Tic douloureux, a masquerade, 57 douloureux, case of, 172 Tissues, fatty degeneration of, 3, 3a Tokio, University of, 155 Treatment, 79-139 special and particular, with illustrative cases, 140-175 Tremor, a masquerade, 52, 53 Tuberculosis, fatty masquerade in, 57, 58 Turtles, production of dropsy in, 24, 25 University of Pennsylvania, 30 Urine, morphology and chemistry of, 65-75 Uterine fibroid, cases of, 147, 148 fibroids, galvanism of, 123 rupture, a masquerade, 47-49 subinvolution, 1 Vander Emde, Henry, 30 Vital force, conservation of, 88-90 Warren Academy, ii Water-gas poisoning, acute fatty degeneration, 3a hot, 84-87 Westminster Abbey, 130 Wheeler, Dr. M. G., 25 Whitney, Commodore W. I., 53 Will, 93 Windom, Secretary, 28, 29 Worry, 93, 94 Yandell, Dr. L. P., 56 Yeasts, alcoholic and acid, in all foods, 84 Yellow fever, fatty degeneration masquerade in, 59 BOOKS, PAMPHLETS. A. The Fatty Ills and their Masquerades. Cloth. Pp. xiv-194. Price, $1.00. B. The Clinical Morphologies of the Blood, Spu- tum, Faeces, Urine, Skin, Vomitus, Foods (including Potable Waters, Ice, and the Air), the Clothing, Uterine and Vaginal Discharges, and Soils; with list of lantern slides. $1.00. C. The Galvanic Treatment of Uterine Fi- broids. Cloth, $1.00. D. Diet in Tumor and Cancer. 25 cents. E. The Galvano-Cautery : its Use in the Re- moval of Piles and Growths. 10 cents. F. Contributions to Laryngology: Thyrotomy modified: Fibroid Enlargements of Arytenoid Carti- lages : A new name for the Ventricular Bands. 10 cents. G. The Best Waters to Drink. 10 cents. H, (1) The Pre-apoplectic State. (2) The Pre- rheumatic State. (3) The Pre-embolic State. (4) Causes of Heart Disease. (5) Food and Tu- bercle. (6) Pretuberculosis. (7) Asthma. 25 cents. I. (1) Cutter's Stem Pessary. (2) Electroly- sis of Myoma. (3) Food as a Medicine in Uterine Fibroids. Gynic Papers, Berlin Medical Congress, 1890. (4) Cleaned Whole Wheat. (5) What Made the Cures ? (6) Uterine Disease Sometimes Mistaken for Consumption. Price, 25 cents. J. Food in Motherhood. Out of print. Expect to publish, 1898. Price, $1.00. K. Cutters' Medical Memoirs. In Preparation. Subscription Price, $5.00. Address Ephraim Cutter, M.D., John A. Cutter, M.D., EQUITABLE BUILDING, 120 Broadway, NEW YORK. 195 CUTTERS' SCHOOL OF MICROLOGY. For Physicians only. First taught in 1869. Principal: EPHE1IM CUTTER, LL.D., M.D. Harr. 1856, Unir. Penna. 1857. Assistant : JOHN ASHBUBTON CUTTER, B.Sc, M.D. Albany, 1886. Lessons, one hour each. Terms, $200.00, in advance, for course. EQUITABLE BUILDING, 120 Broadway, NEW YORK. SYLLABUS OF LESSONS IN CLINICAL MORPHOLOGY. I. Potable Waters. Mode of collecting. Alg^e, such as Diatoms, Desmids, Zygnemaceae, QEdogoniums, Oscillatoriaceae, Protococcaceae, Palmellaceae. II. Fungi, Yeast, Alcoholic and Vinegar; Bacteriaceae, Vibriones, Leptothrix. Protoplasms, Amoebae, In- fusoria, Rhizopods, Asthmatos Ciliaris. III. Foods. Bread, Crackers, Infants' and Invalids' Foods, Changes in Food by Cooking. IV. Dirt, Air. V. Urine. VI. F^ces. VII. Sputum, Vomitus. VIII. Healthy Blood. IX. Clinical Morphology of Skin. X. Tuberculosis. The Pre-tubercular State— Blood, Sputum, Faeces, Urine, Skin. XL Syphilis. The Blood and Urine. XII. Rheumatism. The Pre-rheuma- tic State— Blood and Urine. XIII. Asthma, Hay Fever, La Grippe — The Sputum. XIV. Thrombo- sis and Embolism. The Pre-embolic State— The Blood. XV. and XVI. The Fatty and Fibroid Degenerations and their Masquerades. Bright's Disease, Diabetes, Enlarged Liver, Stomach and Heart, Atheroma, Apoplexy, Paralysis, Locomotor Ataxia, Cataract. The Pre-apoplectic State— The Blood, Sputum, Urine, Faeces, and Skin. XVII. Malaria. Blood, Urine, Skin, and Sputum. XVIII. Male Neurasthenia. The Urine. XIX. Consumption of the Bowels. XX. Review. Special reference to diagnosis of diseases mistaken for others. Uterine Dis- ease for Consumption. Male Neurasthenia for Con- sumption and Rheumatism. Heart Diseases for Con- sumption. Fatty and Fibroid Degenerations for Consumption, Rheumatism, etc. The Physician is taught how to use his microscope daily. He becomes his own teacher at the end of the course. The diseases noted are usually covered. The detection of the predisposing states of tuberculosis, rheu- matism, thrombosis, apoplexy, Bright's, heart diseases (to name no more) , and the removal of their causes ; and the diagnosis of the diseased conditions, with the positive management of such that a certain percentage are permanently ameliorated, are amongst the duties of thejphysician. 196 Cutters* Medical Memoirs TO CONTAIN. I. The Technique of the Micro- scope. II. The Germ Diseases. III. The Fatty Ills. IV. The Fibroid Ills. V. The Gravel Ills. VI. The Ills Due to Fibrjemia and Allied Conditions. VII. The Cancerous or Malignant Ills. VIII. Food in Motherhood. IX. Diseases of Women, Specially in the Line of Work Estab- lished by the Senior Writer in 1868 as to Management of Uterine Displacements. X. Ethics and Polemics of Medi- cal Practice, Specially as to the Management of Chron- ic Disease. XI. Music, Galvanism, etc. It is hoped : to issue the above dur- ing 1898. The writing will be on the line of practical work in medicine as to diagnosis and management of disease. SUBSCRIPTION PRICE, #5.00. EPHRAIM CUTTER, M.D., JOHN ASHBURTON CUTTER, M.D., 120 Broadway, Equitable Building:, New York, 197 ■■