DIAUMOSIS MEDICATION H616.07 544 R3 SCUDER A 522808 DUPL + ARTES 1837 SCIENTIA VERITAS LIBRARY OF THE UNIVERSITY OF MICHIGAN PLUR BUSUNUM MINIHIL FLEBUR SI QUAERIS PENINSULAM AMOENAMI CIRCUMSPICE HOMOEOPATHIC LIBRARY SPECIFIC DIAGNOSIS: A STUDY OF DISEASE WITH SPECIAL REFERENCE TO THE ADMINISTRATION OF REMEDIES. BY JOHN M. SCUDDER, M. D., Professor of the Principles and Practice of Medicine in the Eclectic Medical Institute; author of "The Practice of Medicine," "The Practice of Medicine in Diseases of Children," "The Principles 79 46 of Medicine," Diseases of Women, Specific Medication and Specific Medicines,” etc. TWELFTH EDITION. Reprinted by request, not revised since 1890, ἐκλέψω CINCINNATI, O.: JOHN K. SCUDDER 1913. Entered according to Act of Congress, in the year 1874, BY JOHN M. SCUDDER, In the office of the Librarian of Congress. Copyright, 1903, by THE SCUDDER BROS. CO. Fb El 1 PREFACE. IN presenting this volume to the profession, as a com panion to "Specific Medication and Specific Medicines," my object has been to make a study of the prominent ex- pressions of disease, with reference to the administration of remedies. However learned we may be in pathology, and associate branches of medical study, unless we can make our knowledge point to means for the relief of suffering, the arrest of disease, and restoration to health, it will be of but little use. We believe that the expressions of disease are uniform, and always have the same meaning, and that the action of reme- dies is something definite aud uniform-" that like causes always produce like effects." If we properly study our cases, so as to determine a definite condition of disease, and know the direct action of remedies in such conditions, we will have a certain and rational practice of medicine. 250230 iv PREFACE. і I concede that the study is difficult, but it is difficult principally lecause it is new, and sufficient observations have not been made. Physicians have so long practiced by rote, and taken it for granted that there was no "certainty in medi cine," that we have not the material we would wish for spe cific diagnosis. But attention is being-directed to it, and the time is coming in which the field will be full of observers. No apology is made for the shortcomings of this little book. though I hope that in the main, experiment will prove the correctness of its statements. It would be singular if there were not some errors, and some things to be corrected by further experiment and study. It does not profess to be a complete treatise, or to give all the information that might be thought desirable. But it is a study of disease, which may be continued by other books and at the bed-side of the sick. If it serves the purpose of stimulating investigation and thought, pointing the road to a better system of medicine, I will be fully compensated for the labor. CINCINNATI, Nov. 15, 1874. i ON THE STUDY OF DIAGNOSIS. WE E wish to make a new study of Diagnosis--one that will show us the relation between symptoms of disease and the curative action of drugs. Evi- dently this is what we need to give us a rational prac- tice of medicine-very certainly it must be the founda- tion of specific medication. It is yet the opinion, that "diagnosis" has reference to the classification of disease according to the received nosology; that it means naming the affection "bilious fever," "typhoid fever," "pneumonia," "nephritis," etc. And so it does with the genus doctor, at large, and their souls travail in diagnosis until a suitable name is deliv- ered. And then they consult their memories and books for recipes to throw at this name, which to them seems almost an entity. It looks absurd when thus plainly stated, yet it is true to a far greater extent than the majority suppose. If we examine the literature of the profession, we find that writers on the "Practice of Medicine" labor to (9) 10 STUDY OF DIAGNOSIS. } make diagnosis in this way, and so arrange the symp toms of disease that their readers may be enabled to follow in their lead. The student would certainly think, from this teaching, that getting a name for a disease, was the first and principal object in medical practice. Not only does this seem the principal, but the only end of medical study, and men pride themselves on their skill in naming diseases-calling it diagnosis. What can be more natural than that medicines should be prescribed at names, when so much trouble is taken to affix them? And so we find that treatises on thera- peutics are efforts to associate drugs with names of dis- ease, with a-"this has been used with advantage". "this has been employed in," etc., etc. The trouble is that almost every remedy in the materia medica has been prescribed at the more common diseases—pneu- monia, for instance-and the student has difficulty, not from the paucity of his means, but from their abun- dance. Some go a little further than this. They want a name for their disease, it is true, but they also make their diagnosis extend far enough to guide their thera peutics. Thus they determine a condition of the stom- ach that indicates an emetic, constipated bowels a ca- thartic, dry skin a diaphoretic, scanty urine a diuretic, periodicity Quinine, sleeplessness or pain an opiate, heat and dry skin baths, etc. Add to this counter-irri- tation for the relief of local disease, and we have the ordinary round of treatment. This kind of diagnosis is well enough-is very much better than that which simply names the disease—but it also is very crude at times. For we find at times that there are very much better means to relieve the stom- STUDY OF DIAGNOSIS. 11 الله ach than an emetic; and that in some, where seemingly indicated, it would do more harm than good. That constipation is not an indication for cathartics, and that this class of remedies are so used as to do a vast amount of harm. That impaired secretion from the skin does not mear diaphoretics; for when most indicated they will frequently not cause secretion; and that other means, not directed to the skin, will cause it. That scanty urine does not mean diuretics, for they will fre- quently fail to influence the kidneys when they seem to be indicated most, and will sometimes still further ar- rest secretion. Periodicity does not always mean Qui- nine, for Quinine fails nine times where it succeeds once, sometimes intensifying disease, at others produ- cing a disease peculiar to itself-quinism-worse by far than the disease for which it is given. And sleepless- ness does not mean Opium, for it fails frequently, and, as generally used, does far more harm than good. It is still worse when the physician thinks he sees the need of cathartics. diuretics, diaphoretics, tonics, Quinine, nervines, etc., and gives them all at once, or in a miscellaneous hodge-podge. The common result is to intensify the disease, derange the stomach, and impair the vegetative nervous system. The remedies are fre- quently given so that the action of one opposes that of another, as for instance a cathartic with a diaphoretic, or at such times that they can not possibly do what they are intended for. How, then, shall we study diagnosis? Is there any better method than that usually pursued? I believe there is a right way to study diagnosis—one that will prove satisfactory to patient and physician- will name the disease for the one, and determine a ra- 12 STUDY OF DIAGNOSIS. tional therapeutics for the other. Such a way I endeav- ored to point out in my Principles of Medicine, to which my readers are referred for my opinions in extenso. Man has but one body, and though it may be divided into parts, each has the same life, is supplied from the same blood, governed by the same nerves, and has tre same nutrition and waste. Only in so far as drugs act on special parts or organs, need we study disease of these independent of the organism at large. Man has but one life, and it is the same for all parts. The normal manifestations of this life we call health; the abnormal manifestations of it disease. If we can always think of disease as a method of life, in a living body, we will have gotten rid of an old error, and have made the first step toward a correct diagnosis, and a rational therapeutics. Disease, then, is not an entity-something to be for- cibly expelled from a living body-but is actually a method of life. It can not be purged from the bowels, vomited from the stomach, strained from skin and kid- neys, or exorcised by counter-irritation. Such means may do good, as when they remove an offending sub- stance, or when they establish a function that is defi- cient, but they should have a rational use. The life of disease is not as good as the life of health, neither in the whole nor in any individual part. It is always exhaustive, impairing the life now, and the life to come by renewal of tissue. It makes no difference what may be the seeming condition of the body or a part in disease, the real condition is, an impairment of life. We study disease, therefore, as a method of living; and we treat the diseased body as a living body, which STUDY OF DIAGNOSIS. 13 - has been placed in such position that its life has been enfeebled or deranged. We next want to understand clearly the structure and uses of the various parts of this one body. We want to know clearly the conditions necessary to healthy life, and how their change works that we call disease. If we can understand clearly the relation of a condition or function to healthy life, we are in a position to learn how the change in condition or function produces dis- ease, and a correct therapeutics is at once suggested. Examining the human body, we find certain condi- tions and functions underlie others, and seem to be first elements in the sum of life. Of these I may name tem- perature, circulation, innervation, nutrition and waste, and the blood. We always study these first, and we want to know the exact character of the wrong, in one or all, and how that wrong may be corrected. There Going one step farther, we want to know the relation of these conditions and functions to one another. is a general relation in health; possibly they are of equal importance in the problem of life. But in disease one or other may stand first, and serve as a basis for wrong of life in many directions. Thus a disease involving every function of life, may arise in a wrong of the temper- ature and circulation of the blood. There is a want of appetite that tonics will not reach; a wrong of secre- tion that can not be righted with cathartics, diaphoretics and diuretics; a wrong of innervation that can not be reached with narcotics and nervines. Direct remedies that restore normal temperature and circulation, control the entire process of disease; like a card-house, the re- moval of a first card is sufficient for the overthrow of the entire structure. · 14 STUDY OF DIAGNOSIS. It is not so easy, always, to determine which wrong is thus first, yet with care it may be determined-and this is an essential in good diagnosis. A disease pre- senting similar symptoms-the same symptoms to an ordinary observer—may rest equally upon a first lesion of the circulation, innervation, nutrition and waste, blood-making, or the conditions of the blood. We want to know which stands first, and then rectifying the first wrong the treatment is easy and successful. Disease has certain expressions, which we call symp toms, as health has certain expressions. We find that the manifestations of life in health are very uniform, and consistent, and one can hardly mistake their meaning. So in disease, the expression of morbid life is uniform, and constant, and does not vary in different individuals, as many have supposed. If we determine in any given case the expression of diseased life, we will find it the same in all cases. It has been claimed, and tacitly admitted that symp- toms of disease were so changeable and inconstant, that they could not be depended upon with any certainty. This was certainly true to those who made their di- agnosis according to the recived nosology, and then pre- scribed at the name. For as very diverse pathological conditions would be grouped under each name, the symptoms would of course vary, and the treatment would show the element of uncertainty in so marked a maner that idiosyncrasy would be constantly called in to explain the trouble. We propose studying the expressions or symptoms of disease with reference to the administration of reme- dies. It is a matter of interest to know the exact char- acter of a lesion, but it is much more important to know STUDY OF DIAGNOSIS. 15 the exact relationship of drug action to disease expres- sion, and how the one will oppose the other, and restore health. If I can point out an expression of disease. which will be almost invariably met by one drug, and health restored, I have made one step in a rational practice of medicine. I have no hesitation in affirming that if we have once determined such relationship, we have determined it in all diseases alike, in all persons, and for all time to come. If, with this symptom or group of symptoms, my Aconite, Nux or Podophyllin cures to-day, it will cure to-morrow, next year, and so long as medicine is practiced. If it cures Tom, it will be equally applicable in the same condition to his father, mother, wife, or mother-in-law. "Do you mean to say," asks the reader, "that the present system of nosology is useless?" Yes, so far as curing the sick is concerned, that is just what I mean to say. Not only useless, but worthless-a curse to physician and patient-preventing the one from learn- ing the healing art, and the other from getting well. But you may ask, "how would you make out the certifi- cate for the Undertaker?" That's just what we wish to avoid, we don't care about furnishing subjects, and would very much rather people should die of old age, and then we would write it in English-" old age." The first lesson in pathology we want to learn is, that disease is wrong life. The first lesson in diagnosis is, that this wrong finds a distinct and uniform expression in the outward manifestations of life, cognizable by our senses. The first lesson in therapeutics is, that all remedies are uniform in their action; the conditions be- ing the same, the action is always the same. We learn 16 STUDY OF DIAGNOSIS. to know the healthy man-know him by exercising all our senses upon him. We want to know how he feels, how he looks, how he smells, how he tastes, and what kinds of sound he makes. Then we want to learn the diseased man in the same way, and compare him with our healthy standard-certain expressions of life mean- ing health, and certain other expressions meaning dis. Then we study the action of drugs upon the sick, and when we find them exerting an influence op- posed to disease and in favor of health, we want to know the relation between the drug and the disease- between disease expression and drug action. tase. I do not say that we should not study drug action in health-indeed I think it a very important study. You may, on your own person, study a wholly unknown drug, and determine its proximate medicinal action. How? Easy enough. You will feel where it acts; that points out the local action of the drug, and as a matter of common sense, you would use it in disease of that part, and not of a part on which it had no action. You will feel how it acts-stimulant, depressing, altering the innervation, circulation, nutrition and function. If now you want to use it in disease, use it to do the very things it did in health, and not as our Homœopathic brethren would say, to do the very opposite things. This might not seem altogether pertinent if we were studying old diagnosis, but new diagnosis means medi- ‹ine, and must point out the cure for the particular case in hand. STUDY OF DIAGNOSIS. 17 THE STUDY OF LIFE. The diagnosis that we are studying has a physiologi- cal basis, and we want to learn something of the kind of physiological knowledge necessary. Is it that which may be learned from Carpenter, Draper, Huxley, etc. ? Most decidedly it is not. The knowledge from books is most important, excellent in its place, but worth nothing here unless supplemented by a new study. We must study the living man, and learn to recognize every manifestation of this life by our senses. Nothing less will serve the purpose in rational mcd- icine. We want to bring our own senses to bear upon him, and know how he feels, tastes, smells, and how he looks and what sounds he makes. This study of the living man, the most important study in medicine, is al- most wholly neglected. Men live a lifetime, and know nothing of the manifestations of life. Students become conversant with books, attend their lectures, pass their examinations, and yet have no practical knowledge of human life. And physicans will practice medicine a life- time, and yet fail to know what healthy life is. How would you make a good surgeon? There is but one way. He must exercise his senses on the human body, and learn to know it for himself. He studies upon the cadaver, and learns the relation of parts; and he also studies the living man, and learns to recognize these relations by the sense of touch. Your accom- plished surgeon recognizes a displacement or fracture, as soon as his eyes rest on the part. Let him pass his fingers over a limb in the dark, and he will tell you if anything is wrong, and just what the wrong is. He is a good surgeon, just exactly as he is an expert in this. 18 STUDY OF DIAGNOSIS. Not a year passes but what we have one or more suits for malpractice against physicians of our school, arising out of bad bone-surgery. (They have quite as many in other schools.) Why these cases? Simply be- cause they have not taken the trouble to learn on the cadaver and living body for themselves, just how it is made, and the relation of one part to another. Any man, whether he is a surgeon or not, can so train his senses, and know the anatomy of man, that mistakes would be impossible, and cases of malpractice would be the result of accident, or the fault of patients. 1 say to the student, study anatomy and physiology on the living man. Observe him closely with your eyes, until you learn his varied expressions. See him walk, sit, lie, work, eat, breathe, talk, etc.. Feel of him, and sce how he is made, and what he feels like in different parts. Learn every prominence of bone in the body, and its relation to articulations, blood-vessels, nerves, organs, etc. Hear every sound he makes, and learn to recognize its character. And, lastly, learn to recognize all of the many smells of which he is the base. Learn him from the crown of his head to the sole of his foot, and analyze him with your own senses, and you will have the foundation for a good physician. I place very great stress on this method of studying physiology, and recommend it to the old practitioner as well as the medical student. No knowledge in the memory can take its place. It must be the basis of a rational practice of medicine, for unless we know what health is, we can not know disease, and unless we know disease we will have a random and very uncertain therapeutics. I have already called attention to the necessity of STUDY OF DIAGNOSIS, 19 training all our senses so that we may be able to observe well. These faculties are like many others, they may be so trained under the influence of the will, that after a time they work automatically, and with a rapid- ity that is astonishing. This is the work of time-but time placed where it will do the most good. All that one need do, to have good, active senses, is to use what he has rightly. There is no mistake about these things, and I will guarantee any physican a success that will astonish him, if he will put them in practice. Need I say that the reward is great. Outside of professional reputation, and the ordinary rewards of successful business, there are sufficient returns. A man's conscious life is in and through his senses, and as these are educated and en- larged, his life becomes larger, and his pleasures in- creased. Nature is a most bountiful mother, and her laws bring certain compensation; and of these there is none truer than that "a man grows as he is rightly used." APPLIED ANATOMY.-The ordinary study of anatomy is a good thing, and is the basis for a sound medical education. Yet I am sorry to say that the study of anatomy with the majority of physicians is very " ordi- nary." It is a good thing to be able to name the various bones, processes, muscles, and organs of the body, but it is very much better to know them, as a man knows his best friend. I may know a man's name, and yet know really nothing about him, physically, mentally, or morally. So it is in the common study of anatomy, the memorizing of names takes the place of that study which will enable one to really know the structure of the human body. 20 STUDY OF DIAGNOSIS. 1 A good anatomist will strongly insist on dissection as an important means of learning. He well understands and endeavors to impress the fact that it is only by personal examination that one may know the various tissues and organs, and their relation to one another. The surgeon supplements this by the additional state- ment that the most important preparation for the use of the knife in surgery, is the use of the knife in dis- section. Not only to acquire anatomical knowledge, but to know the resistance of different tissues to the scalpel, and to train the sense of touch. An accomplished physician should be a good anato- mist—the skilled diagnostician is a good anatomist. No one need say he has no opportunity, for every one can make opportunity. A dead man is a good thing in this study, but any animal or part of an animal wili serve the purpose of the man who really wishes to know, and there is not so very much difference between man and the remainder of the mammalia. The nearest butcher shop will furnish material in abundance-from eyes, to tongue, larynx, trachea, bronchial tubes and lungs; the digestive canal and its associate organs; kidneys, etc. whilst a quarter of lamb or veal gives pretty good muscular dissection. The worthless curs prowling about the village or town, give excellent facilities for dissection or vivisec- tion. Chloroform the brute, and he is ready for work, and you may educate your touch on living tissue, as well as learn anatomy.. In the olden time the study of anatomy was com- menced with the bones-pot with pictures or plates of bones This study in which bones are tangible reali- ties, and convey to the sense of touch and the eye their ? STUDY OF DIAGNOSIS. 21 peculiarities is the right study. Every physician should be able to recognize any bone by the sense of touch, and at once give it its proper position. Just as he should be able to recognize the normal from the ab- normal in shape, size and position. The skeleton prop- erly articulated is a valuable adjunct, and if it was thoroughly studied by the hands in a dark room, we would have but few cases of mal-practice in bone- surgery. But this study of anatomy from the skeleton, and by dissection, assisted by reading and lectures, is but pre- liminary to a more important study. We want to study anatomy upon the living man. We want to know the situation and the relation of various parts, sc that we may be able to put our finger upon them at once, and detect the slightest variation. We want the impress of this living man upon our senses, so that they may know him intimately. What does he look like? What does he smell like? What does he taste like (in so far as taste is applicable)? What sounds does he make? And how does he feel? We want to know his every cassion, standing, sitting, lying, on his back, sides, etc. His expression scles in life, nfluence in 'uation of in activity, and at rest. We study his their arrangement on the bones, and their giving the body motion. We study the blood-vessels in the same manner, and lea.. to trace their course by the prominences of bone, elation to muscles, etc., and going deeper, we study osteology again, as the bones are clothed in tissue. No man need excuse himself for want of opportu- nity, so long as he possesses a body of his own, «nd there are so many other bodies that might be engag、d for the purpose. • 1 22 STUDY OF DIAGNOSIS. There are two objects in this study, both important. The one is to know the mechanism of life, and the other is to educate the senses. The importance of the first will not be disputed, and before we have concluded this study, I think the other will be conceded. APPLIED PHYSIOLOGY.-The knowledge of physiology from the books is a good thing, but it is not sufficient for our purpose. We not only wish to learn that Car- penter, Huxley, and others, have witnessed certain phe- nomena, and learned to know them as constant expres- sions of life, but we wish to know them of ourselves, and through our senses. Dr. Huxley introduces the study of physiology by saying "The body of a living man performs a great diversity of actions, some of which are quite obvious; others require more or less careful observation; and yet others can be detected only by the employment of the most delicate appliances of science "Thus, some part of the body of a living man is plainly always in motion; even in sleep, when the limbs, head and eyelids may be still, the incessant rise and fall of the chest continue to remind us that we are viewing slumber and not death. "More careful observation, however, is needed to de- tect the motion of the heart; or the pulsation of the arterics; or the changes in the size of the pupil of the eye with varying light; or to ascertain that the air which is breathed out of the body is hotter and damper than the air which is taken in by breathing. "And lastly, when we try to ascertain what happens in the eye when that organ is adjusted to different dis- tances; or what in a nerve when it is excited; or of STUDY OF DIAGNOSIS. 23 ! what materials flesh and blood are made; or in virtue of what mechanism it is that a sudden pain makes one start—we have to call into operation all the methods of inductive and deductive logic; all the resources 01 physics and chemistry; and all the delicacies of the art of experiment." Huxley is an admirable teacher, probably the best living, and we will do well to get an idea of these methods. The first lesson we learn from these brief, but expressive paragraphs is, that we are to observe this man, who "is plainly always in motion," and that we are not to be satisfied with the observations of another. Then follows the natural sequence in these observa tions. At first the gross expressions of the body, and the difference between the man awake, asleep, dead Next a "more careful observation," determining the motion of the heart, etc. And lastly, the skilled obser- vation, from a trained mind, aided by the various in- strumentalities and appliances of science. Books are useful in this study, though not the object of study; it is the man we want to know, not the book nor its author. The book may serve as a guide-board, pointing the way, and at the same time give us a standard of comparison. It tells us what to exercise our senses upon-what to observe-and it informs us what others have observed, and what is the common standard of healthy activities. There is nothing in the life of the man but should be a subject of close scrutiny. We want to know him in the entirety of his action, as we wish to know him in every detail. And we want to know him so inti- mately and thoroughly, that this physiological man shall be always present with us as a standard of com parison. 24 STUDY OF DIAGNOSIS. The reader will at once see the necessity of this study as a basis for diagnosis. The physiological man is the man of health, the pathological man is one who has left this common standard of being. The physiological man is the standard of measurement, the common mean that we measure from. To have a measurement at all, it is necessary to have a fixed point to start from; this healthy man is the fixed point. Measurement has reference to certainty, and certainty is what we most desire in medicine. A measured mile is a definite distance, an imaginary mile, having its origin and termination in the cranium of Paddy Ochhone, is a very different thing, though very like the ordinary measurements in medicine. The first thing that the physician wants, then, is a sound physiological standard, which he carries with him as he makes his rounds. It is lain by the side of the patient in bed, sits by him on the chair, stands by him, walks by him, puts out its tongue, extends its hand to give the pulse, has lungs, bowels, kidneys, re- productive apparatus, etc., always at your service, and open for comparison. Disease is wrong life, and a wrong presupposes a right. To determine the existence of a wrong, we must know what the right is; to determine the character of the wrong, we must compare it in all its parts with the standard right. This is diagnosis, as the reader can at once see. How now shall we get this physiological standard. Clearly by observation with our own eyes, and the use of our own senses. Each man must make it for him- self, and give it distinctness by the education of his own senses. Theoretical knowledge will not do. STUDY OF DIAGNOSIS. 25 If we take Huxley's first example, "awake, asleep, dead,” we find an excellent study. Can you tell the difference between the appearance of sleep, sleep and death? Hardly by the first glance, and possibly only by a very close examination, and some experimenta- tion, (the last especially evidences a state of uncer- tainty). But if we carefully observe the phenomena of sleep, in the infant, the child, the adult, we will soon have a healthy standard, and the expressions of sleep are so distinctive, that no one could deceive us by slamming sleep. So, too, if we carefully observe and study death, we will never mistake it. There are distinct expressions of body in death that can never be counterfeited. It is not only the absence of motion, of respiration, of pulse, or heart-beat, of heat, but there is an absence of the expression of life in its totality, and an expression of lifelessness that is characteristic. The relaxation of death is distinctive, as is the rigor-mortis, as is the de- composition of tissue. It is a good thing to have a standard of death for comparison as well as of life. Not that we usually have any doubt of death, but that we require it as a measure of life. It is well to have two points to mea- sure from-the standard of life and the standard of death. There is an approximate death, as well as a total death; a dying by degree, or part, as well as a dying at once and in entirety. Taking a man in entirety, we find a distinct expres- sion when he walks, stands, sits, or lies. Every part of the man talks to us, his hands, his arms, his legs, his feet, even his "calves may wink," as described by Dickens in one of his Christmas stories. 3 26 STUDY OF DIAGNOSIS. We not only learn from this much of the physical life of the outer man, but learn of the life within. The expression is the shadowing forth of the underlying nervous system, and this again of the real or spiritual man behind this. As physical, mental and moral health has a distinct expression in the outer man, which we purpose using as a standard of admeasure; so all diseases, physical, mental and moral, have a distinct expression in the outer man. You will no more find disease under a healthy exterior, than you will find a devil in the garb of an angel. We have a standard temperature, which we may learn to recognize by the hand, though it is best to measure it with a thermometer. We have a standard electrical condition as an important factor of life, which we will learn to recognize in the general expression and movement, the special expression of the face and eyes, and by the touch. And we have a standard formative force, which we will recognize in the expres- sion of tissues, and the sensations they give to touch. We have a standard color for the general surface, and for special parts that the eye will learn to recog- nize, and use for comparison. We make this study thorough; it is the skin at large, and then those por- tions where the circulation is less free, where it is very superficial and free, the nails, hair, veins, etc. We have a standard color for mucous membranes, for lips, gums, tongue, teeth, etc. We have a standard in touch-of smoothness, resist- ance, elasticity, size and association; and we have it of every part of the body. Of course we have not learne it of Huxley or Carpenter, but by the use of our own hands on the human body. STUDY OF DIAGNOSIS. 27 We have a standard respiration, in frequency, full- ness, depth and freedom, which is distinct and clear, and which we know of ourselves by observation. We have a standard circulation, which we know at the radial artery, by the even, distinct, regular blood wave that passes under our finger, as well as by the ex- pression and color of the surface, and the expression of parts associated with the heart in action. We have a standard condition of the digestive organs, which we learn from books and by observation. It don't take long to learn, even by the general expres- sion, and the special expression of the muscles of the mouth, whether a man has a good appetite, good diges- tion and good blood-making. Even constipation will be shadowed forth in the outer man so that one may re- cognize it. Blood-making and nutrition must have distinct ex- pression, and a standard for measurement will be readily formed, for all functional activity is dependent upon nutrition. The standard of healthy excretion by skin, kidneys, and bowels is readily formed by observation. Not ob- servation on the sick, and under the influence of drugs, as many suppose, but upon the well. Thus we see it is possible to so learn our physiology, that it may serve as the basis of a rational practice of medicine. And I think every reader will see that this education is essential to good diagnosis, and that its at- tainment is the first object in medicine. This is not a question of schools; it is a question of sheer empiri- cism, (call it quackery if you will), or rational medi- cine; it is a question of whether the physician is to be a coadjutor and aid to death, or whether his influence will be upon the side of life and health. 28* STUDY OF DIAGNOSIS. METHODS OF DIAGNOSIS. Where do we find the expressions of disease? When you think of this question a moment, it does not seem so easily answered; indeed it furnishes good material for thought. Probably we had better preface it with another. How do we find the expressions of disease? Man has knowledge of things external to him, by means of the general sense of touch, and the special senses- sight, hearing, smell, taste. We may ask, then, when brought in contact with the sick, what do we feel, see, hear, smell, taste, that differs from the normal condi- tion-health. What the patient feels, sees, hears, smells and tastes is not so important, for his senses are im- paired by disease, they have never been educated, and his mind is not in a good condition to receive im- pressions. I imagine the reader saying to himself-well-really -I don't know about that. I don't feel my patients much, and am not sure that I learn much by feeling. I see them-but-I don't know that I can tell the char- acter of disease by sight. I hear-yes-I hear all the patient has to tell me about his bowels, number of ope- rations, whether he passes wind up or down, or both, makes water, where he has aches and pains, etc. I don't smell much, unless I examine; the bed-pan or chamber utensil, and I don't want to taste in the sick room. That is he makes his diagnosis, from the patient's feelings, and not by the use of his own senses, -a very imperfect way of making a diagnosis. We have called attention to the uncertainty of diag-, nosis from "what the patient says," yet it is the com-: 44. STUDY OF DIAGNOSIS. 29 mon means of diagnosis with all schools of medicine. If the patient was wholly truthful there would be suf- ficient uncertainty, for they have little knowledge of disease, little skill in observation, and from disease they are incapacitated for reasoning. The patient can not, in the very nature of the case, know very much of his dis- ease, and does not know that little well. If now we supplement this by the well known ten- dency to exaggeration by the sick and friends, we find still more uncertainty. You ask when you visit a patient whether he slept. The wife answers—“ not a wink," and yet you know from the patient's expression that he has rested during the night, though his sleep may have been broken. Or the nurse answers, “Oh, yes, he had a good night's rest," though the only ground she has for supposing so is because she slept herself, but the patient's expression shows you he has passed a restless night. You ask if the patient has taken food-"no, he hasn't been able to take a bite," though you find on persistent inquiry, that he has had broth, or milk in sufficient quantity. You ask if he has passed urine-" Oh, yes, sufficient," yet you see by the pinched, anxious countenance, and position of abdomen and pelvis, that he is suffering from retention or sup pression of urine. You ask if the patient suffers much —“Oh, yes,” is the reply, "I have had severe pain," or "I have suffered intensely," yet you see by the countenance that the statement is false or overdrawn. I do not believe that my patients are worse in this respect than others, yet I have occasion to say to myself every day, when listening to the patient's or nurse's story—" Madam, or sir, you are lying." Indeed, I have always made it a rule to believe nothing that 30 STUDY OF DIAGNOSIS. was told me in a sick room, unless it was corroborated by my examination of the patient. I have tried the experiment several times, of seeing how far the patient and attendants would go in their exaggeration. Take one that is imaginative, and by leading questions and promptings you can get the symptoms of every ailment to which man is subject; and the story will have more consistence and semblance of truth, the more the patient knows of disease. The nurse is frequently as bad as the patient in this respect, and quite as easily led to exaggeration. I had an illus- tration of this a few weeks since in the person of a monthly nurse. The mother and child were doing well, yet you would think from the nurse's description that they were just on the point of having every ailment that the puerperal state would afford. The mother was not easily influenced, or the nurse would really have made her sick. Why has a good physician better success in diseases of children than in other cases? There is no doubt of the fact, and I have heard it remarked many times- "I would much rather treat children than adults- medicines act better." You can't question the child, and you learn but little that is important from the mother- how do you get your information? True, the mother and friends will say "it is so hard to doctor children, you can't find out what is the matter with them" But a good practitioner knows better than this, and though possibly he has never thought about the subject, he knows he can treat children better than grown persons. Why? For the very good reason that he uses his senses, and prescribes from what he knows, instead of taking the say-so of patient or nurse as a basis for the STUDY OF DIAGNOSIS. 31 1 prescription. If I should suggest to you, that in the practice of obstetrics you should place dependence upon the statement of nurse and patient, instead of making an "examination "-you would think it most absurd. Yet, in reality, it is not more absurd, than de- pending upon the story of nurse and patient in ordi- nary diseases. If these are facts, and I think the experience of every reader must satisfy him that they are, we want to change our method and get a better basis for diagnosis and prescription in diseases of the adult. Let us sup- pose every patient a child-which they are in fact, so far as medicine is concerned-and give them the same careful examination that we would to the child, and thus reach conclusions from what we know, rather than from what patients or nurses say. We do not wish to lose the advantage of any infor- mation we may get from patient or nurses, but we pro- pose to make no suggestions in the manner or charac- ter of questions, that will bring false answers. There are some things the patient will know, and a little care will frame the questions so as to get at the real facts. There are some things the friends or nurse will know, and direct questions will usually bring straight replies. But there are many things that neither can know any- thing about, at least with any certainty, and these should always be avoided. All answers should pass in review of our own senses, and what we know of health and disease. These are the judges, and if the evidence is good it will have their approval; if it does not have their approval we throw it to one side. We do not purpose receiving anything that is opposed to what we know of disease, and we do 32 STUDY OF DIAGNOSIS. not purpose believing anything that is opposed to the evidences of our senses. THE EDUCATION OF THE SENSES. We have already seen that the education necessary to make a good physician, is not from books, or of the memory-both good in their place, but insufficient. The education that gives the best results, and makes the successful practitioner, is of the senses, and of the brain to receive impressions, and make deductions. We have called attention to the proper study of an- atomy, by which one may know the structure of the human body of himself; and the right study of phy- siology, by which one may know the various activities of this mechanism. To make these attainments re- quires study-not midnight oil burned in reading books, but the continuous exercise of our senses upon the human body, living and dead. The same course of study is necessary to know dis- ease. The description from Aitkin, Wood or Scudder, is not the knowledge we want; it is not what another man knows that is of advantage to us, any more than it is another man's dinner that sustains our life. want to know disease for ourselves, and we learn it by the exercise of our senses upon diseased bodies. Wo If the senses, then, are the instruments by which we obtain knowledge, it will at once be patent to the reader that their development and goodness will be the mea- sure of our ability and our attainments. Hence the man of educated and acute senses will be far superior to and have every advantage over the man who has nót been thus trained and developed. ' STUDY OF DIAGNOSIS. 38 Most persons seem to think that the human senses are natural, not acquired-that they are born to us, and not the result of education. This is a very great mis- take, and a grave error to the physician. Man is born with an organism that, so to speak, has germinal capaci- ties for use, and its future development is by normal use. The child at birth has perfect hands and arms, every bone, muscle, blood vessel and nerve being there; but they are as yet wholly useless. Its feet and legs have all the parts of the adult, but it can not walk, or even wag its toes under the influence of the will. Its eyes are perfect, yet the images formed upon the retina are wholly without meaning, and might quite as well be a blank. The child slowly learns to use its hands, and months pass before it can hold an object, and a still further time before it can move the object in obedience to the will. We see it day by day learning to see, slowly taught by its surroundings. And the adaptation of the nether limbs to walking is the persistent work of the first twelve or sixteen months. Compare the child of these attainments of one year with the child of two years, and you see a wonderful difference. The education has been continually going on during this period, and with continued use in right directions comes increased devel- opment. At the third year there is further improve- ment, and thus, as we go on to the fifth, the tenth, the twentieth year, we observe a continued education of the senses, and a better development of them. I want to call attention to the fact that we find every grade of development in different individuals, from the first year up to maturity, and that this development does not always depend upon the original capacity. A 34 STUDY OF DIAGNOSIS. difference in use or in education, so to speak, gives dif- ferent capacities. It is not in the initial or starting point, but in the method of progress, that gives the fully developed sense. If the child has been rightly directed, and the senses have been rightly used, they will have proportionate capacity. Many who would admit that the human senses are acquired, think of them as being acquired very much as the man increases in stature and weight, and some- thing essentially belonging to this period of growth. They conclude that the senses grow with the body, and attain maturity when it has reached the full size and stature of a man; and now a man, having his full capacity, will find neither increase nor diminution so long as he may live. They measure a man in all his parts in this way; his every function is now developed for life. A greater mistake could not. be made. The law of development is always in operation in the human body, as it is throughout the animal and vege- table world. As any organ or part is rightly used, it grows in capacity. Not only in infancy, in childhood, up to adult years, but each and every year of a man's life to old age. It is more marked, of course, when the repro- ductive powers are active, but it is always a law of life. The man between thirty and forty years, will find that he still has the germs of a large capacity, which needs. but the right use for development. He may grow legs, arms, body, chest, lungs, brain, the sense of touch, of taste, of smell, of hearing, of sight, if he will; all that is necessary is, that he should rightly use that he has. Shakspeare makes his typical Dogberry say, "To be a well-favored man is the gift of fortune; But to write and read comes by nature," STUDY OF DIAGNOSIS. 35 But however it may be with reading and writing, very surely acute sight, smell, taste, hearing, touch, do not come by nature. We all recollect the tedious process of education-how we slowly attained our A, B, C's, and what a work we had done when we could spell b-a ba, k-e-r her, baker-and so on through, whether it has been little or much. This is the type of education, and this is the way it is obtained-little by little, and by continuous application. But there is another view of the question, quite as important to many persons. The law is not only ope- rative in the one direction-to increase functional capacity but quite as much so in the other direction- to lessen or take away that we have. The part or organ disused loses its functional capacity, becomes atrophied, and finally loses the power of reproduction-is wholly gone. The Indian Faakar, who vows to hold his arms above his head, finds after years are passed, that they are no longer obedient to the will, are lost. This is the case with any part of the body-with the organs of special sense, and with the brain and its functional ac- tivities. It is the application in the human body of Christ's parable of the talents: "For the kingdom of heaven is as a man traveling into a far country, who called his own servants, and de- livered unto them his goods. And unto one he gave five talents, to another two, and to another one; to every man according to his several ability; and straight- way took his journey. Then he that had received the five talents went and traded with the same, and made other five talents. And likewise he that had received two, he also gained other two. But he that had re- ceived one, went and digged in the earth and hid his lord's money." 36 STUDY OF DIAGNOSIS. The reader will recollect the application of the para- ble-the one who had used his talents found them in- creased; the one who buried his, had taken away from him that which he had. The divine Teacher enunci- ated a law as wide as the universe, and as applicable to physical and mental growth, as to moral development. It is just as applicable to the training of the senses of the physician, as it is to the growth of the moral nature of man. The lesson is clear: if we want anything, we must work for it; if we will not work, we lose that we have. Man has conscious life in his brain and through his senses. Take away his senses, and he has lost all com- munication with the world without. Through his senses he has pleasurable life, and it is deep and broad in proportion to their development. One would think that this would be sufficient incentive to their full de- velopment. But, unfortunately, men dislike work, not realizing that even this will prove a pleasure. It is the continued and orderly exercise of parts that gives them increased capacity. Not by fits and starts, but continuously, day by day, week by week, month by month, year by year. The organs of special sense have in them a mechanism for skilled use, as well as for the gross purposes of life, and it is this skilled use we pur- pose to call forth in diagnosis. Man has five senses-of touch, of sight, of hearing, of smell, of taste-all of which are useful in this study, and all require training. The physician of unskilled touch, sight, hearing, smell, taste, can never be suc- cessful. It is hardly necessary to give examples of this, as every reader's experience will show it a truism, but a few may stimulate thought. STUDY OF DIAGNOSIS 37 í In the obstetric art the skilled touch is the important element of success to the accoucheur. Without it he is groping in the dark, and is obliged to sit passively by the bedside and wait. He can not know, and of course can not give intelligent assistance when assistance may be required. In the saine way the unskilled touch could never use a knife in surgery, could not pass a catheter, could not recognize the variations of the pulse, could not determine the condition of the skin, could not do a great many things that might be done if the touch were educated. The untaught eye can not distinguish the variations of form, size, color, and other physical properties of bodies, which tell of condition, and functional activity. To the extent that it is uneducated the man is blind, and of necessity is groping in the dark. " The untaught ear has no use for the beautiful mechan- ism that adapts the organ to receive the varied impres- sions of sound. It can hear thunder, and it can hear noise, but to the "concord of sweet sounds it is deaf. In medicine the ear requires education by use in order to detect some of the minute sounds, as the " respira- tory murmur," and a still further education to detect the minute shades of difference in sound, which tell of disease. - The same may be said of the educated senses of smell and taste. The uneducated nose may recognize the genus stink, but has no power of analysis; as it may recognize fragrance, and have no pleasure from it. To the uneducated taste all substances are savory, or un- pleasant, and with this gross classification the sense is satisfied. To the educated taste there is every grada- tion of the one and the other, and a power of discrimi 38 STUDY OF DIAGNOSIS. 1 nation that is sometimes really wonderful in its acute ness. HOW MAY WE CULTIVATE THE SENSES ?--This is the really important question, though the answer has been partly given in the above study. We cultivate the senses by continuously using them, and their education is the work of months and years. We can always find objects to exercise them upon, the training school is all about us, and we have only to make intelligent use of the facilities at our command. It is, well, however, to have an intelligent plan, and follow it up assiduously, recollecting that "time, patience and perseverance will accomplish all things." The senses are intimately associated with the brain, and their education implies a mental training as well. Whilst we develop the organ of sense by use, we develop the brain upon which the impression is made, and the higher brain which takes cognizance of, and analyzes the sensations. The development is thus a double one, and both are essentials in correct diagnosis. A plan presupposes thought, the act of the rational, mind, as well as orderly activity.* *SENSATIONS AND JUDGMENT.-(That the reader may have before him a brief synopsis of the physiology of sensation, I give the following description from Huxley's Physiology:) "In explaining the functions of the sensory organs, I have hitherto confined myself to describing the means by which the physical agent of a sensation is enabled to irritate a given sen- sory nerve; and to giving some account of the simple sensations which are thus evolved. " Șimple sensations of this kind are such as might be produced by the irritation of a single nerve-fibre, or of several nerve-fibres by the same agent. Such are the sensations of contact, of STUDY OF DIAGNOSIS. 39 : : THE TOUCH.-The tactile sense has its highest de- velopment in the hands, and it is in this locality, espe- cially, that we purpose cultivating it. Delicacy of touch is associated with a normal condition of the skin, and necessitates care of the hands. It does not mean a life of idleness, but it means proper protection from cold, cleanliness, and an avoidance of such work as thickens. the epidermis, or gives it unnatural hardness. "Clean hands and a pure heart" is a gospel expression that we can well apply to medicine, both essentials. Show me the physician with rough, unpleasant, grimy hands, and I will show you the man who is unsuccessful in his calling, and is being gradually imbruted in his nature. The hand is the characteristic feature of man, and is the outer expression of the reason within, and the spirit that is above the beast. A French writer once remarked, "Show me the man's hand, and I will tell you what manner of man he is." A plan of use? It suggests itself at once-we will exercise our touch upon every object we come in con- tact with. Here are objects large and small, long and short, rough and smooth, of varied form, with special inequalities of surface, of varied consistence, and we warmth, of sweetness, of an odor, of a musical note, of whiteness, or redness. "But very few of our sensations are thus simple. Most of even those which we are in the habit of regarding as simple, are really compounds of different sensations, or of sensations with ideas, or with judgments. For example, in the preceding cases, it is very difficult to separate the sensation of contact from the judgment that something is touching us; of sweetness, from the idea of something in the mouth; of sound or light, from the judgment that something outside us is shining, or sounding." 40 STUDY OF DIAGNOSIS. purpose feeling them until we can recognize them as well in the dark as in the light. We take the bones of the skeleton, and learn to re- cognize them by the touch as well as by the sight. Our Profs. Freeman or Howe will tell you the bones as well by touch as by sight. We take the dead body, and train the touch to recognize every part, by its form and resistance. We take the living body, and learn to re- cognize the impressions given by the skin, fasciæ, mus- cles, bones, and by the cavities of the body. Attention has already been called to the necessity of the skilled touch in the obstetric art. You know a ver- tex presentation by the impression made upon the fin- gers brought in contact with the head. You determine fontanelles and sutures in the same way, and thus know the position. The nates give a different impression, and the finger recognizes the genitalia of male and female, as additional evidence. It recognizes a shoulder or elbow, a hand, a knee, or foot. How? Not intui- tively; we have no natural knowledge of this kind, it is cultivated. Shall we wait until in obstetric practice we learn and acquire a skilled touch? That would be very bad policy, especially for our patients. The sense of touch is first trained by general use, and then we find opportunity upon the child already born, to acquire the knowledge of how a cranium, suture, fontanelle, nates, genitalia, shoulder, elbow, hand, knee, foot, feels-it is easy enough to find the opportunity, if one is inclined to learn, and it is easy to get this necessary skill in obstetric diagnosis if one is inclined to improve his opportunities. SIGHT.—The sense of sight is one of the most impor- tant in diagnosis, and it, like others, requires education, STUDY OF DIAGNOSIS. 41 both as to the eye which receives and the brain upon which impressions are made. The eye receives im- pressions of color, and by education learns to detect the form, size, distance, and many of the physical prop- erties of objects. Color being one of the prominent characteristics of health and disease, the ability to accurately distinguish colors must be a great aid to the physician. The un- educated eye receives the impress of color very much as it does light and shade, attaching about the same meaning to it, but when trained by use, it readily de- tects slight variations. It is quite easy to form a cabinet of colors, from natural objects which may be studied in detail, and this is suggested to the reader in preference to giving the color sheets here as first intended. The vegetable and insect worlds furnish them in great abundance, and specimens can be readily preserved. Quite soon the eye has learned to distinguish color from light and shade, and in a few weeks will become quite skilled, and yield much pleasure by the habit of observation thus acquired. There is nothing trivial in nature, and nothing so poor or worthless that it should not be known; this is especially true to the physician because he must be a student of nature, to be able to deal with nature's greatest work, the human life. The practical education of the eye to color is com- pleted upon the human body. We find distinct varie- tics of color in health-of skin, of mucous membranes, of parts where the circulation is superficial, showing arterial blood, of veins, of the eye, the nails and the hair. We want to learn to know the healthy man by his color, and we may know him by this. 1 · 4 42 STUDY OF DIAGNOSIS. + There is also abundant opportunity to educate the eye to the variations of color in disease, so that they will be readily recognized, and their true meaning known. We may procure types of these morbid colors, so that we will be enabled to refresh the memory with them. Some of these will be given further along in this work, but the reader is advised to select samples of other colors for himself. The training the eye to the determining of size is not so important, yet will be found quite useful. One phy- sician will recognize a swelling, which evidences local disease, which another has failed to notice. So one will recognize a fullness of skin, of cellular tissue, of mucous membrane, of tongue, which another fails, to see. Training the eye to recognize form is very important, both to the physician and surgeon. The trained eye of the surgeon at once detects a deformity, and deter- mines its cause, whether from fracture, dislocation, or structural disease. The trained eye of the physician / should be able to recognize at once the general form of health, in the posture and expression of the patient, and the evidences of disease in the changes of form, in position, in sitting, lying, in the position of the limbs, and in the expression of the features. The trained eye recognizes changes in the form of the tongue, which express conditions of disease, and call for special reme- dies. HEARING.-Physicians do not seem to have realized the importance of the ear in diagnosis. It is true that we have a system of physical diagnosis for diseases of the chest, which the student is advised to learn; but, STUDY OF DIAGNOSIS. 43 unfortunately, the advice is not supplemented by the lesson we are trying to teach-that these organs must be educated. The student applies his untrained ear, and hears nothing, or is unable to distinguish variations in sound, and becoming disgusted, gives physical diag nosis over to the expert or the specialist. Even if he persists in trying to learn, he finds that he can not hear the sounds described in the books, (simply because there are no such sounds produced), and is thus discouraged. concourse of All nature is vocal with sound, and the sounds are the expressions of life. The old Hebrew poet recog- nized this fact, and gives expression to it—even “the morning stars sang together." All nature is vocal with sound, but to the uneducated ear it might quite as well be still, for it expresses naught to him. Train the ear, and educate the brain, and we have a sweet sounds," taking the entire range of life, express- ing all its feelings, its hopes, its fears, its griefs, its cares, its pleasures, its pains. It recognizes the love song of the bird, the tone of wedded bliss, the gush of parental affection, the cry for assistance, the shriller cry of assault, the song of victory, the wail of defeat, and the moan of death. There is a fascination in the study of sound when once commenced, that will carry the observer on, and he will find a continued reward from it. If we take up the single study of the expression of animals in their cry, we find it of wonderful interest. We learn to re- cognize the speech of bird and beast, though we may not have slept with the fairies, as did the little boy of old. The cry of pain in the animal kingdom is so ex- pressive, that it will be recognized at once, and pretty soon we will find ourselves locating and giving charao 44 STUDY OF DIAGNOSIS. TUDY O ter to the disease by this expression. One of the most striking examples of this I have ever witnessed, was in the case of a pet goat that was poisoned by eating paint. The cry was as expressive as that of a child, and one involuntarily located the wrong in the intes tinal canal-it was lead colic. "Ears ye have but ye hear not," is applicable to the physician in ordinary. He is diligent in questioning the sick, and seems to think there is wisdom in the thoughts of the poor sick brain. The expressions of the voice, which tell the condition of the brain, and of the life of the man, to a considerable extent, is never heard, the doctor is deaf. In auscultation, the first lesson is in learning to hear. It requires close and continued study to hear the respi- ratory murmur distinctly, and this study must be con- tinued if we expect to recognize the variations of this and the sounds produced in the bronchial tubes. Skill in physical diagnosis does not come by nature; it is the result of study, and the education of the ear and brain. No man can expect to succeed in it unless he is willing to give months to it, first to educate the ear to the hear- ing and analysis of sound, and next to the hearing and analysis of the sounds heard in the chest. SMELL. Of still less importance is the sense of smell, and yet it has its place in diagnosis. A good nose is a good thing, and the sense of olfaction should not only be a safeguard to the individual, warning him of noxious influences, but should be a source of pleasure as well. To some extent this sense is instinctive, especially as it warns against irritant substances, and leads to their avoidance. But it is one that may be educated to a STUDY OF DIAGNOSIS. 45 ▼ very high degree. We have examples of this in some varieties of merchandising. The wine merchant grades his wine by its boquet, as well as the taste. The tea dealer will classify his wares, and price them, by their odor, as will the fancy grocer with a majority of the edibles he deals in. We want a good nose for the purposes of diagnosis, and we especially want a good nose that it may look after the hygienic surroundings of our patients. There is an abundance of bad smells about the sick room, some peculiar to the condition of disease, and some the result of want of cleanliness and ventilation. We want to know them, and to do so we require an educated nose. What is an educated nose? It is one so trained by use that it transmits sensations to the brain, which has also been trained by use to receive and analyze them. In other words, it is the association of brain and nose in the work. This sense is educated in the same manner as the others. We find odorous objects, and use this sense in their cognition. Pursuing the study we learn to discriminate between odors, and to recognize them immediately, and the character or condition of bodies they express. It will require but little training to enable this sense to detect the unpleasant surroundings of a patient. The first impression of the air of the sick room tells of a want of ventilation, of a deficient supply of oxygen, a superabundance of carbonic acid gas, and a surplus of foul gases. The nose not only recognizes these wrongs, but will insist upon their abatement. It says, open the windows and doors, let in the sunlight, build an open fire, and wash up. There is no mistaking the language, 46 STUDY OF DIAGNOSIS. f and the physician feels that he must carry out its orders. It recognizes a want of bathing upon the part of the patient, dirty clothing, dirty bed-clothes, a foul chamber utensil under the bed, dirty dressings, dirty or bad food, dirty medicines, and says in unmistakable lan- guage, get these things away. "Cleanliness is next to godliness," and of far more importance in the recovery of the sick. It will also point out conditions of disease, and talk to you of special medicines. It says, typhoid, sepsis, loss of life and breaking down of tissue plainly; and sug gests for your consideration an individual of the group antiseptic chlorate of potash, sulphite of soda, sul- phurous acid, carbolic acid, baptisia, permanganate of potash, etc. TASTE.-Whilst the sense of taste is a good thing, and should be well cared for, we do not propose to make much use of it in medicine. It is well, however, to use it upon the food prepared for the sick, because we find a great many wrongs here. People have not lost the old impression that the sick need no food, and that it makes but little difference what kind is given, or how it is prepared. If the physician does not look after this, he will find many times that his patient is being starved because food is unpalatable, or so badly prepared that it is indigestible, or so changed in char- acter, that it really does the patient a wrong. If the physician has a right appreciation of the ne- cessity of good food, and the nurse or friends know that he will make it his business to look after it, and see that it is well prepared, they will probably use 1 STUDY OF DIAGNOSIS. 47 more care, and will ask for information when it is re- quired. There are some things that the physician will do well not to cultivate a taste for or in. He should not be a connoisseur in liquors. It is far better that the patient run the risk of getting bad whisky, brandy, or wine, than that his medical attendant should have acquired the ability to determine for him. If there is any one road shorter than another to want of success, loss of character, poverty and wretchedness, it is the habit of tippling. The road seems especially broad, smooth and direct to the doctor, and he may well apply the old Latin quotation from Virgil: "Facilis descensus Averni"; and the second line-" but to escape is indeed a work of difficulty." We have thus briefly examined the means by which one is prepared for the practice of medicine. The reader will have noticed that we place great stress on self-education, as the basis of skilled diagnosis and therapeutics. All knowledge is available in medicine, and we do not wish to depreciate the ordinary medical course of study, and would advise that the study of medicine and the collateral sciences should be carried as far as possible-and it is possible, even with the busiest man, to make very considerable attainments outside, as well as inside the range of studies usually pursued. Still, unless the physical organism be trained to use, our other education will prove a dead letter. It is the means that brings man in relationship to, and gives him cognizance of his surroundings and the world at large. He not only has knowledge of things through his senses, but his practical knowledge is in proportion to their education and acuteness. f 48 STUDY OF DIAGNOSIS. In the study of disease it will be best to change the order in which we have noticed them here. The phy- sician sees his patient first, and then the examination commences with the sight, touch, hearing, smell, taste. This may be regarded as the natural order, and we will observe it in the further study of the subject. THE USE OF THE SENSES IN THE DIAG- NOSIS OF DISEASE. It is well to notice that we have a two-fold object in studying. We wish to determine the locality and nature of disease-its pathology; but we also wish to determine those agencies which will oppose disease and restore health-its therapeutics. These are both im- portant studies, and we do not wish to neglect either, yet the reader will see that the last is the practical one. If we can determine what will cure, we have accom- plished the important object of medicine. The means of cure have held a secondary place in medicine, and indeed it seemed sometimes that it held no place. Physicians would be very learned as to patliology, and able to divide and subdivide the lesions of function and structure until they would be “ an im- mense multitude," yet you could count their remedies upon your fingers, and these were of the olden time, devitalizing, and most absurd. You would find an im- mense volume on pathology and diagnosis, teeming with wisdom, and a therapeutics meager and feeble in everything but its power to do harm. STUDY OF DIAGNOSIS. In this study we wish to make therapeutics occupy the first place, and the diagnosis will mean remedies, whenever this is possible. We do not care so much to affix a name, by which the wrong may be known, as to prefix a remedy by the means of which the disease will not be known. Or to put it in plainer form, the object ɔf examination is to determine what will cure. It is my opinion that we can so study disease, that its symptoms or expressions will talk to us of individual remedies, and in language so plain that it can not be misunderstood. As this is the first object of study, we will keep it constantly in view. DIAGNOSIS BY THE EYE. The educated eye requires no prompting to do its work in the examination of the sick-its training is to this end. It takes in the appearance of the patient and his surroundings in all their detail. An effort of the will is required to make the mind attentive, and to co- ordinate the impressions, and reach conclusions from them. It would seem unnecessary to say that many many conditions of disease find outward expression through the muscu- lar system and its investing connective tissue and skin, and that the physician should recognize them as soon as his eyes have made their examination, and yet the study of medicine is pursued as if this were not so. The doctor is very eager to see the patient's tongue and feel his pulse, and ask all manner of questions pertinent and absurd, but he is blind to these natural expressions, or if he learns, it is slowly and because the facts are 5 50 STUDY OF DIAGNOSIS. 1 forced upon his consciousness. The reason is obvious- his attention has never been directed to it, and he has failed to study the subject as it was presented to him in practice. This study requires an exercise of the mind, and that the reader may commence thinking to advantage, we will take some very familiar examples in the animal kingdom. Let us see, for a moment, how animals ex- press emotion (the action of the mind in so far as it is developed). If you notice your dog or cat for a few days, you will see the clear expression of the entire range of the emotions, anger, fear, love, hate, joy, grief, consideration, conclusions reached, etc., and so plainly that you can make no mistake. Examine your horse, and you will find the same clear and striking language of expression. It is really wonderful, this voiceless language of animal life, and well repays study. Supposing now we study the expression with refer- ence to rest. You notice the dog taking his siesta, and carefully scan his posture and feature, and the idea of rest is so strongly impressed that you are sure you could not be mistaken. Whistle sharply, and notice the change to a position and expression of activity and ex- pectant attention. Give his ear a sharp pinch, and you will see the evidences of pain as clearly as you would in the expression of man. Think of the sickness you have seen among animals. The cat or dog with a "sick stomach "—before they have made an effort at vomiting you have jumped for the door to let them out. In ordinary ailments the drooping head, ears and tail, the expressionless eyes and face, and indeed the entire want of muscular ex- pression, tells the story of impairment of life. Take STUDY OF DIAGNOSIS. 51 an irritative disease, of the intestines for instance, and the marked contraction of muscular tissue; the rough ened coat, the strong drawn lines of the face, the re- tracted lips, tell you the kind of wrong. Would you know if your horse was sick by his ex- pression? I think you would, and if the subject had a little study you would know the kind of sickness as well. If you found him in the morning with drooping ears and tail, expressionless eyes and nose, you would bardly take him out for a day's ride. You recognize the expression of exhaustion from over-work, and feel so much for your companion that the stable is visited before retiring, and you probably know from his pos- ture and expression in the stall whether he is resting, or in a condition that precludes rest. If in driving you notice the ears drooping or turned backward continuously, you know there is something wrong. That the one means a wrong of exhaustion, and the other a wrong of irritation. If you notice his tail fall helplessly between his legs, you feel sure he is in no condition for work, is suffering from exhaustion. Suppose you observe an unnatural twist in his tail to one side, and you are quite as sure he is sick, the dis- ease one of irritation, probably colic. Carry this observation a little further, and watch the process of labor in animals, and you will be still more surprised at the wonderful mechanism of voiceless ex- pression. You will be able to read the history as plainly as if expressed in language. The process of dilatation, the expulsive second stage, the tedious and difficult labor, the irregular and inefficient uterine contractions, the rigid soft parts, etc. Let us watch the case of a cow with puerperal fever, (yes, she has puerperal fever, 52 STUDY OF DIAGNOSIS. and other puerperal diseases as has the human mother), and you will see every phase of suffering, and see it so distinctly that you can not forget it if you would. You notice a horse put out one of his feet in stand- ing, and at once you think of disease. By the expres- sion of the leg and its position, your accomplished horseman will locate the wrong for you; telling you whether it is in the shoulder, leg, knee, in the lower articulations, or in the hoof. How does he tell? Be- cause the leg has a language, and he has learned it. I have cited these examples as subjects of thought. This study requires thought, and the doctor is so little in the habit of right thinking with reference to human disease and diagnosis, and so certain that everything must be known, that it is better to get a basis for thought outside. If the reader recognizes the truth of these statements, and can confirm them by observation, he will say at once-"if disease is thus clearly ex- pressed in the lower animals, there must be similar ex- pressions in man, and the subject is well worth my attention." Disease has a voiceless language, and it is this we wish to study, but in order to do so successfully, the reader must get a basis for thought, commence to think of it, and find his illustrations in every-day life. It is well to have clearly before us at the commence- ment, the objects of the examination, and the facts that may be determined; they may be classified as follows: 1st. The right life that we designate as health; 2d. The wrong of life that we call disease-the amount of vital impairment; 3d. The condition of rest; 4th. The con- dition of unrest; 5th. Disease of excitation; 6th, Dis- ease of depression; 7th. Pain; 8th. The evidence of local disease, both as to structures involved, and kind. STUDY OF DIAGNOSIS. 53 DECUMBENCE. In acute disease, the impairment of life is usually such that the patient assumes and keeps a horizontal position, as this requires the expenditure of much less power than any other. We use the term de- cumbence in preference to the old medical one, decubi- tus, and it is defined by Worcester as "The act, or the posture of lying down, prostration." In health the de- cumbent position is associated with the idea of rest, and when assumed at unusual times, with the idea of debility. Thus the first idea obtained from seeing the patient in bed is, that there is impairment of life. It would be a blessing to the sick if the physician could get this fact so thoroughly impressed, that he would re- fuse to depress the life still more by the administration of drugs. Evidently this fact is one of much importance, and whilst the general expression may not be absolute evi- dence, it is among the best we have. If in acute dis- ease the patient keeps his bed all the time, there is con- siderable impairment of life. If in ordinary chronic disease we find the patient frequently assuming the de- cumbent position, and maintaining it for a considerable time, we have to consider it an evidence of enfeeble- ment, and we husband our patient's strength, and em- ploy the class of remedies known as restorative, with appropriate food. Studying the patient's expression in bed, we find that it gives us additional information. If he lie on his sides, changes his position readily, holds his shoulders and extremities in position, we conclude that the im- pairment is not great as yet. But if we see him in- clined to lie upon the back, or if upon the side that the shoulder falls forward or down, the arm falls and is 54 STUDY OF DIAGNOSIS. expressionless, the upper leg and hip show the inclina- tion to fall, and even the soft tissues of the face droop, we are certain there is great impairment of life, and the treatment must be conservative and restorative. In the worst case, where the patient lies continuously upon his back, and is inclined to slip toward the foot of the bed, physicians usually recognize the approach of death. There can be no mistake about the importance of the inquiry, or the character and certainty of these expres- sions. If we know that the life is feeble, we will care- fully husband it, and guard against unnecessary expen- diture. If we know the life is feeble, we will be sure to avoid unpleasant and harsh medicines, especially the class antiphlogistic. If we know the life is feeble, we will appreciate the importance of keeping the digestive organs in good condition, and giving the necessary food. If we know the life is feeble, and we have any- thing in our Materia Medica that will aid and strengthen it, we will realize the importance of its use. To determine the condition of rest or unrest is of great importance. When a man or a part is sick, rest is necessary to recovery, and very much of the treat- ment used looks to procuring rest. The position of de- cumbence is assumed to get rest, yet we find that many times it is not sufficient. It is well to know that we have to think of this with reference to sleep as when awake, for though sleep usually means rest in health, it may not give rest in disease. It is well to get an idea of perfect rest in health, as a standard of comparison. Observe the child sleeping, and the perfect equipoise of the entire muscular system, and the natural position of the extremities show the condition of rest. Even when the child falls asleep in STUDY OF DIAGNOSIS. 55 a constrained and unnatural position, the body so adapts itself to it, that we have the idea of rest. A group of harvest workmen, taking their noonday rest on the grass under the shade of a tree, will give every shade of this restful expression, and is well worth our study. We learn something here that can not be told in words, but which serves as an excellent standard of comparison at the sick bed. Notice the position of a healthy person in sleep, especially how the body accom- modates itself to bed and pillows, so that one position will sometimes be maintained the whole night, with rest to every part. Now when we come to examine the sick, the condi- tion of unrest is clearly expressed. The body does not accommodate itself to the bed, and the effort to main- tain the position shows itself in the constraint of dif- ferent parts. We see it in the evident contraction of the cervical muscles to hold the head in position; in the unnatural flexure of the extremities to maintain the body and themselves in position. We have every gradation of these expressions, from that which comes some time after the position of the body has been moved, when the patient is tired, to that which is so continuously marked, that we know the patient has not one moment's rest. The position of the body also tells us something with reference to the fifth and sixth propositions-whether the disease is one of excitation or depression, especially as regards the circulation. This also is an important element in diagnosis, and refers us to appropriate remo dies. Te condition of excitation is marked by constraint and indue contraction. We notice it in the expression } 56 STUDY OE DIAGNOSIS. of the entire person, and of special parts. In the first it has reference to the entire body, in the second it is more the expression of local disease. The ideas that we get is of want of ease, and of constant effort on the part of the muscular system to obtain it. An unusual · and constrained position of one or more of the extremi- ties is quite a common expression. It may be but flexure of one leg, throwing it out or from the body, or a contraction and elevation of one shoulder, or a prone fore-arm and hand with marked muscular contraction, or an unpleasant constrained position of the head, with prominence of the cervical muscles, or we may have it in facial expression. Once the mind is directed to it, these features are quickly learned, and having the knowledge of health, we quickly determine the extent of the lesion. The evidences of enfeebled function-depression, are just the opposite. Whilst in the previous case, we have an unusual excitement of the nerves, and of the vascu- lar systems, in this we have deficient innervation, and impaired circulation. In this there is want of expres- sion, the body lies, so to speak, as if no effort were made to hold it in position; parts fall of their own weight. This want of expression is noticed especially in the subcutaneous muscles, and in the skin, giving an un- pleasant uniformity of surface, and a sodden expression to the soft tissues. PAIN, or suffering, is expressed in every portion of the body, and one may learn to recognize it as soon as the eyes strike the body, and yet it would be difficult to describe the expression. When pain is associated with, or the result of undue excitation, the expression will be that just named under this head. But if asso STUDY OF DIAGNOSIS. 57 1 ciated with, or the result of an enfeebled condition, either of the entire body, the part suffering, or the brain, the general expression may be quite the reverse, and will more resemble the exhaustion that follows ex- cessive grief-one of anguish. As has been clearly shown by Darwin,* expression is most marked in those muscles in most common use, or those associated with mental activity. Thus we would *I have now described, to the best of my ability, the chief ex- pressive actions in man, and in some few of the lower animals. I have also attempted to explain the origin or development of these actions through the three principles given in the first chap- ter. The first of these principles is, that movements which are serviceable in gratifying some desire, or in relieving some sensa- tion, if often repeated, become so habitual that they are per- formed, whether or not of any service, whenever the same desire or sensation is felt, even in a very weak degree. Our second principle is that of antithesis. The habit of volun- tarily performing opposite movements under opposite impulses has become firmly established in us by the practice of our whole lives. Hence, if certain actions have been regularly performed, in accordance with our first principle, under a certain frame of mind, there will be a strong and involuntary tendency to the performance of directly opposite actions, whether or not these are of any use, under the excitement of an opposite frame of mind. Our third principle is the direct action of the excited nervous system on the body, independently of the will, and independently, in large part, of habit. Experience shows that nerve-force is generated and set free whenever the cerebro-spinal system is ex- cited. The direction which this nerve-force follows is necessarily determined by the lines of connection between the nerve-cells, with each other and with various parts of the body. But the direction is likewise much influenced by habit; inasmuch as nerve-force passes readily along accustomed channels. " 58 STUDY OF DIAGNOSIS. expect to find the most marked expression in the face, and next probably in the hands and the extremities. If the reader will think for a moment, he will probably recall distinct expressions in these forms. He will especially recollect the common expressions of pain in the muscles of the orbits and frontal region from con- traction of the corrugator supercilii, some of the fibres of the occipito frontalis, the orbiculars, and sometimes. the zygomatic. His attention will only need be called to the forced contraction of the flexors of the hand during labor, the involuntary expression of pain, and to similar contraction in the feet. Indeed here is a most excellent study, and one may learn the natural history of pain by closely observing a few labors. There is nothing like having a familiar example for study, and we may look still further at the phenomena of childbirth. I need hardly say that these expressions have the same meaning as in ordinary disease, though here we find them greatly intensified. Possibly we will get as good an idea of rest during the absence of pain in a natural labor, as we can get anywhere. And in a difficult labor we will get as distinct an idea of the state of unrest. We observe the pain finding expression in marked muscular contraction of the muscles of the upper and lower extremities and the forced flexion of the muscles of the hands and feet. We also see the ex- pression of pain in the countenance, but in natural labors it is evanescent and not very marked. In diffi- cult labors, especially where the pains are inefficient, we find the constant contraction of the "muscles of pain," and it is one of the evidences of this condition. The evidence of local disease will be found in the po- sition of the body with reference to removing pressure STUDY OF DIAGNOSIS. 59 from the part, or giving it support. This is sometimes so distinct that the attention is at once directed to the affected part. If the position of the body is such as to take off muscular pressure, we conclude that the disease is one of excitation. If, on the contrary, the position is such as to give additional support, we would think of it as being one of impaired innervation and circulation, possibly congestion. A man gives a diseased leg rest in the same manner as a horse. Flexion takes off ten- sion, and if the disease is one of irritation, the limb is flexed. Disease of bladder or rectum will be indicated by flexure and, crossing of one thigh over the other. Disease of the abdominal viscera, by flexion of the thighs upon the trunk and probably flexion of the trunk. Disease of one kidney will be announced by flexion of the body on the affected side. Disease of stomach by marked flexion of the trunk, and relaxation of the ab- dominal muscles and diaphragm, and thoracic respira- tion. Disease of one lung will be indicated by the flexion of the body on the affected side, and the droop- ing of that shoulder. Disease of the upper lobe of the lungs will be indicated by the falling of the shoulders forward, the additional curvature in the upper dorsal and cervical spine, and by abdominal respiration. A very natural expression of disease is the involun- tary movement of the hand to it. In typhoid fever, when the patient is seemingly wholly unconscious, we find the hand over the bladder in retention of urine, as it seeks the umbilicus when disease of Peyer's patches is marked. The child suffering from disease of the ear involuntarily carries the hand to the affected part. In acute disease of the kidneys the hands are carried to the loins. In some gastro-intestinal disease the hands 60 STUDY OF DIAGNOSIS. sometimes go to the mouth, and it seems as if the child wanted to get something out of its throat. It is always well in low forms of disease to carefully watch these expressions, as they give us early intimations of local trouble. And in diseases of children, when we have to depend almost wholly upon our own observation, it is also well to carefully observe every expression. FACIAL EXPRESSION.-The fact has already been no- ticed that mental states find easiest expression in the usual channels of innervation, and through those mus- cles in common use. This is not only true of mental activity, but is also true of disease. There is no disease without a wrong of the nervous system, and I think I may add with truth, that there is no wrong of life that is not represented upon the surface through the nervous system. We may not be able to read it, because our senses have not been trained to observation, and we have not sufficient experience, but the fact that disease is thus expressed should stimulate to study. The face will show clearly the right life that we call health; and the wrong life we call disease. If one will closely study the expression of the face in health, and compare it with the expression seen in sickness, this fact will be clearly seen. It not only tells us of im- paired life, but also of the kind of impairment, and of the remedies that will remove the wrong, and restore health. It will be well to make this study with refer- ence to-1st. The condition of the brain; 2d. With reference to the condition of the sympathetic nervous system, and associated spinal cord; 3d. With reference to the condition of the circulation and the blood; 4th. With reference to local disease; 5th. With reference to pain; 6th. Resistance of disease. 1 STUDY OF DIAGNOSIS. 61 + The CONDITION OF THE BRAIN is very clearly ex- pressed in the face, and we have learned quite a good deal of its language. We may subdivide this study into-a. With reference to the circulation, determiuation of blood, congestion, inflammation, effusion; b. The nu- trition of the brain; c. Its functional activity. DETERMINATION OF BLOOD is marked by flushed face, bright eyes, contracted pupils, and general but moderate contraction of the facial muscles. The expression is one of excitation, and the patient is restless and uneasy. The direct remedy is Gelseminum. The indirect means are those which relieve vascular excitement, and the old-fashioned derivatives-counter-irritation, etc.* CONGESTION is marked by dull eyes, dilated pupils, immobile pupils, expressionless face, patient dull, in- clined to sleep, and eventually coma. *A bright and sparkling eye is as characteristic of a pleased or amused state of mind, as is the retraction of the corners of the mouth and upper lip with the wrinkles thus produced. Even the eyes of microcephalous idiots, who are so degraded that they never learn to speak, brighten slightly when they are pleased. Under extreme laughter the eyes are too much suffused with tears to sparkle; but the moisture squeezed out of the glands during moderate laughter or smiling may aid in giving then lustre; though this must be of altogether subordinate importance, as they become dull from grief, though they are then often moist. Their brightness seems to be chiefly due to their tenseness, owing to the contraction of the orbicular muscles and to the pressure of the raised cheeks. But, according to Dr. Piderit, who has discussed this point more fully than any other writer, the tenseness may be largely attributed to the eyeballs becoming filled with blood and other fluids, from the acceleration of the circulation, consequent on the excitement of pleasure. He remarks on the contrast in the appearance of the eyes of a hectic patient with a rapid cir- STUDY OF DIAGNOSIS. + The direct remedy is Belladonna. In some cases, and when associated with local disease with impairment of the involuntary muscles, Ergot The indirect means are counter-irritation, dry or wet cupping, stimulant cathartics. An intermediate hyperomia, observed in apoplectic conditions is marked by fullness of eyes, which are protruded, fullness of face, prominent veins, and from contraction of the platysma a drawing down of the face and angles of the mouth. For this condition the direct remedies would be Ergot, Lobelia in stimulant doses, Apocynum. The in direct remedies, dry or wet cupping, stimulant hydra gogue cathartics. INFLAMMATION is marked by still greater contraction of the muscles, especially those of the orbits and the frontal region, the deeper flushing of the face, the sharper expression of the eyes, which are dry and pinched, the contracted pupils, and as the life is im- paired, by the appearance of constriction of all the tis sues around the base of the brain. The direct remedies in the first stage of an inflamma- tion of the brain are: The proper sedatives, Aconite or Veratrum, and Gelseminum. These may be followed and aided by such as increase the action from skin, kid- neys and bowels. The indirect remedies are such as may call the excitation to other parts. culation, and of a man suffering from cholera with almost all the fluids of his body drained from him. Any cause which lowers the circulation deadens the eye. I remember seeing a man- utterly prostrated by prolonged and severe exertion during a very hot day, and a bystander compared his eyes to those of a boiled codfish.—Darwin. STUDY OF DIAGNOSIS. 63 EFFUSION is marked by the dullness, and finally by coma. The eyes lose their sharp, bright expression and become dull; the muscles of the lower part of the face relax, as do the muscles that move the inferior maxillary and the mastoid. If the irritation still continues, the contraction of the orbiculars and frontal muscles per- sists, and the evident constriction or pinched appearance around the base of the brain becomes more prominent. If the irritation passes away with the effusion, these muscles gradually lose their power, and the upper part of the face assumes a dull, soddén appearance. The direct remedies are small doses of Aconite and Belladonna, alternated with Apocynum. The indirect means will consist in cupping the spine, and the use of a stimulant hydragogue cathartic. The NUTRITION of the brain is not so easily deter- mined, yet I think we may reach correct conclusions in the majority of cases. The enfeebled nutrition will be marked by a want of expression, especially in the mouth, showing a want of decision. The eyes may have a normal appearance at first sight, yet as we watch them uncertainty is shown in their movements. In some cases, the expression when the patient's attention is not attracted, is very like that which follows exhaustion from excessive emotion. SOFTENING OF THE BRAIN, so called, will be marked by a smooth, placid countenance, the want of expres- sion in the forehead being especially marked. In some of these cases the tissues have their ordinary fullness, and sometimes the soft tissues of the face are unusually full, yet they look soft and flabby, and hang in un- natural folds. ATROPHIC IRRITATION OF THE BRAIN is marked by 64 STUDY OF 'DIAGNOSIS. i the pinched and uneasy expression of the upper facial muscles, the muscles of the orbits and the frontal region. The patient holds his head in a constrained position, frequently inclined to one shoulder, and the face turned to one side, giving the eyes an unpleasant expression of obliquity. The elevation of one eyebrow and the fall- ing of the other, with an apparent divergence in the axis of the eyes, will locate the lesion in or near the cerebellum. The evidences of structural disease vary with the situ- ation and character of the lesion. They may be divided into irritative and atonic, the one showing marked contraction of some muscle or muscles of ex- pression, the other a want of contraction, and conse- quent fullness and drooping. Sometimes in the severest structural disease there is no external expression. The FUNCTIONAL ACTIVITY is very clearly shown in facial expression, and we will observe the entire range from normal function to furious delirium on the one hand, and to entire loss of function and conscious life on the other. ACTIVITY is not only shown in muscular contraction, but in alternate contraction—the play of the emotions— of the muscles. This change of expression is one of the most familiar examples of mental activity. In de- lirium we observe that the play of the muscles is exag- gerated, as indeed is the expression of all the emotions. This is especially noticeable in the expression and movement of the eyes, and their external muscles. WANT OF ACTIVITY is expressed by want of contrac- tion of the facial muscles; dull, immobile eyes, and full lids. The condition of the sympathetic nervous system is ¢ STUDY OF DIAGNOSIS. 65 } pretty clearly shown by the eyes, the orbital muscles, and the tissues about the base of the brain. The disease of irritation is shown by the contraction of the tissues which form the bed of the eye, the retraction of the eye, especially upward, the thinned and constricted eyelids, and the tissues about the temples. In some cases the pinched or contracted alæ nasi is a marked feature. The disease of atony is shown by the full, ex- pressionless eyes, fullness of the lids, pallid and waving alæ nasi, and fullness and want of expression about the mouth. A temporary want of sympathetic innervation that is rectified by Podophyllin, is shown in the fullness of all the tissues of the face, especially the upper portion, and by fullness of the veins. For the disease of irritation, I prefer Aconite, Rhus, Bryonia, Muriatic Acid, Nitric Acid, the selection being made by the other symptoms present. Temporary re- lief is obtained by the local application of Chloroform before and behind the ears, and over the first cervical ganglion. The Chloroform is so applied as to prevent evaporation, and a change in the pulse will usually be noticed in a few minutes from its first application, and the relief is marked, and very frequently it lasts for some time. The disease of atony is met by Nux, Phosphorus, Quinine, stimulant doses of Lobelia, minute doses of Podophyllin, Digitalis, more rarely Veratrum, the bitter tonics and food. Whilst the expression of the face will give us pretty accurate information with regard to the circulation, we may obtain this information more directly elsewhere. If the cellular tissue is full, we think of Veratrum. If 6 66 STUDY OF DIAGNOSIS. it is shrunken, Aconite. If the expression of the eyes and associate muscles is dull, with fullness, we think of capillary congestion, and Belladonna. If the cellular tissue is full, the face expressionless, and the veins prominent, Podophyllin. If the eyelids are especially full, Apocynum. If the eyes have a pinched expres- sion, dry in acute disease, secretion of tears in absence of fever, dry, shriveled epidermis, flushed left cheek, Rhus Toxicodendron. Right eyebrow drawn down, and expression of eye changed, flushed right cheek, Bryonia. These are the most prominent examples, and in each case there is a wrong of the circulation, which may be the predominant wrong. At any rate, the remedies thus indicated will prove curative. With reference to the condition of the blood, we may find more direct expressions than in the face, yet these are not unimportant. The sodden tissue evidences poor blood and poor nutrition, as the firm elastic tissues show good blood and good nutrition. The typhoid con- dition of the blood will be clearly shown in the con- tracted and opaque skin in the one case, and the sodden inelastic tissues in the other. Pyæmia will show itself first, in the marked contraction of tissue about the base of the brain, sinking in of the bed of the eyes, and espe- cially by retraction in the upper part of the orbit. Some local diseases are clearly indicated by facial ex- pression. Disease of the respiratory apparatus will be shown by the expression of the nose and accessory muscles. The lesions of irritation by contraction, the lesions of atony by relaxation. Any one who has watched the progress of an acute inflammation of lungs, of pleura, of bronchia, with irritative cough, must have seen the pinched expression of the nose, and the con- STUDY OF DIAGNOSIS. 67 } traction of the alæ. So marked is this, that sometimes it seems to precede the trouble, and will be marked, be- fore the disease of the respiratory apparatus has full development. The relaxed and waving alæ nasi gives an unpleasant impression of disease, and as before named, has reference to the lesion of innervation, as well as to impairment of the respiratory function. The expressions of the mouth are associated with dis ease of the abdominal and pelvic viscera. Let us take the familiar examples of intestinal worms as an illus- tration. The full upper lip, with pallor, the white lines around the mouth, and picking the nose, is the most pronounced evidence of ascaris lumbricoides. This worm inhabits the small intestine, and the conditions present are atony of mucous membranes, with impaired function, and increased secretion of mucus, and at once we think of the associated symptoms and the intestinal wrong. The remedies will be those which will give normal stimulation to the structures involved, Podophyllin, Santonine, some of the ordinary cathartics, the sto- machic bitters, and sometimes the alkaline salts, or acids, as may be indicated by other symptoms. If fullness in this case means atony and impaired function, and increased mucous secretion, it must mean it always, and we will always think of such remedies as will influence the small intestine and associate viscera, giving normal stimulation and circulation, and restoring functional activity. There is a peculiar expressionless mouth, or an expression of "loss of spirits," with a little depression of the angles of the mouth, that invariably means Nux Vomica. Nausea is shown by depression of the angles of the - 68 STUDY OF DIAGNOSIS. mouth, and slight incurving of the lower lip. If the tissues are full, we know that there is atony; if pinched and shrunken, that there is irritation and determination of blood. It is a singular fact, and one not heretofore noticed, so far as my reading extends, that simulation of these expressions will provoke sensations in the parts referred to. The instance just given affords a marked example. Let a person draw down the angles of the mouth and incurve the lip, and he will be quite certain to feel nausea after a time. In two persons who tried it the sense of nausea was very marked; in one producing vomiting, in the other an arrest of digestion and head- ache. Try to simulate the frontal expression of pain, and it will be singular if you do not wake up unpleasant sensations somewhere, perhaps real pain. Contraction of the orbicularis oris is usually found in some diseases of the reproductive organs, especially of the female. In chronic disease, there is distinct retrac- tion from the other muscles of the face, and the entire tissues seem thinned. In some of these cases the zygo- matic muscles are also prominent. ی مردان PAIN AND SUFFERING are distinctly expressed in the features, yet not always in the same way. Firm con- traction of muscles is the most common expression. Thus every reader will recollect the contracted brow as evidenting pain, especially pain with irritation of the nerve centres. We involuntarily associate contraction of the structures about the eyes, and the wrinkled skin, with pain, or with suffering. But we have the evidence of pain in this region without muscular contraction; indeed there is the reverse, drooping of the tissues, the expression is sad, of the exhaustion that follows exces- STUDY OF DIAGNOSIS 69 sive grief, and we are assured that there is enfeebled circulation in the brain, and the pain is the expression. of atony. It is very important to make these distinctions in order to select remedies. Pain Pain is the result of two very opposite conditions-an excited circulation and an en- feebled circulation. In the one case we use Gelsemi- num, the sedatives, salines, Rhus, Macrotys, Bryonia, as may be indicated. In the other we use Quinine, stimulant doses of Opium, Nux, stimulants, tonics, beef tea or other histogenetic food. Pain in the abdomen, pelvis, or lower extremities, finds expression in the mouth. Acute pain almost always finds expression in contraction of the mouth; when very severe the lips are firmly drawn in, the angles of the mouth retracted, and somewhat depressed. In some other cases, the angles of the mouth are drawn in, and there is that action of the muscles of the upper lip that gives it and the cheeks a full expression. I hardly need call attention to the fact, that some patients resist disease by an influence of the will, and that sometimes this effort is very important. Others yield to it from the first, and thus favor its progress. Every one has made these observations, and will recog- nize the importance of knowing whether a patient re- sists or yields, as it may determine whether he will re- cover or die. Darwin remarks that-"The firm closure of the mouth tends to give an expression of determination or decision to the countenance. No determined man probably ever had an habitually gaping mouth. Hence, also, a small and weak lower jaw, which seems to indi- cate that the mouth is not habitually and firmly closed, 70 STUDY OF DIAGNOSIS. is commonly thought to be characteristic of feebleness of character. A prolonged effort of body or mind im- plies previous determination; and if it can be shown that the mouth is generally closed with firmness before and during a great and continued exertion of the mus- cular system, then, through the principle of association, the mouth would almost certainly be closed as soon as any determined resolution was taken.” I do not think any one can make a mistake here, and certainly it is important to know whether the patient is inclined to resist disease, and is determined to get well, or whether he is yielding, despondent, hopeless. The firm mouth means that the patient will get well if he can. The relaxed, drooping mouth, falling jaw, trem- bling muscles, show us the need of giving the patient courage, and strengthening the will power. It also shows the necessity of increased care to conserve vital- ity, and of the employment of restorative remedies. EXPRESSION IN MOTION. We not only find disease expressed in position, and in persistent muscular con- traction, as heretofore named, but it is also shown in motion. We see a man standing or sitting, and ob- serve that his soft tissues seem to sit on him like a badly fitting suit of clothes, and we think at once of impaired nutrition and degeneration of tissue. But it may be only a want of innervation, from habitual torpor of the nervous system. Set him in motion, and we will soon see whether this is so or not, for there are none so sluggish in this respect, but what they may be aroused. We notice the movements of the person that we may confirm the diagnosis of expression, especially as re- STUDY OF DIAGNOSIS. 71 gards the important point of undue irritation and cir culation, or impaired innervation and circulation. The quick, restless movement is characteristic of the first. The desire to lie still, and the slow movements, of the second. Possibly there is no evidence of disease more definite than this, and it should be allowed its full weight in diagnosis. In some cases the rapid movement is but a means of removing excessive excitement of the brain and spinal cord, as in great grief or joy, or in case of severe, but temporary pain. In such cases it may be looked upon as a means of relief, for if the excessive emotions, or pain were pent up, the person might suffer severely from it. But in other cases, whilst it tells of nervous irrita- bility, the bodily movements give no relief, but even in- tensify the wrong, besides causing exhaustion. In these cases we endeavor to get bodily rest from the first, as a means of allaying the nervous excitation. Every one will have noticed the influence of the phy- sician, nurse, or friend, who with kindness but firm- ness, insists on keeping still. The hand placed upon the body of the sufferer to give support, seems to strengthen the will power, and frequently with an effort on the part of the patient comes rest and relief. There is a case of restlessness from an enfeebled and atonic condition of the nerve centres that requires notice. The unsteady movement, or the evidence of exhaustion following it, with the anxious, depressed countenance, tells the story. In the other case we will find almost continued tension of the muscular system. Whilst in the case of irritation and determination of blood, we would employ the sedatives, with Gelseminum, 72 STUDY OF DIAGNOSIS or remedies exerting a like influence, in that of atony, we would use Quinine, Nux, Phosphorus, stimulants, tonics, and histogenetic food-beef-tea. Increased movement is not associated with structural, or even with severe local functional disease, so that un- less it points to a wrong of the cerebro-spinal centers we do not regard it as an unpleasant symptom. In or- dinary colic the patient is restless, and seems to get re- lief from motion, but in the severer forms of colic, called "bilious," and in acute enteritis, he remains very still. In local disease the patient favors the affected part in movement. Frequently the first evidence we have of morbus coxarius, is the care shown in moving the leg and placing the feet in walking, and the elevation of the hip to remove pressure from the joint. Turning the toes inwards, both in movement and rest, has the same signification. One can readily distinguish a wrong of the pelvic viscera by the movement of the hips and extremities, showing the constant effort to prevent stress or pressure of the parts. This will be noticed in some uterine disease (irritative) as well as in displace- ments. In chronic disease of the kidneys, a forward curvature of the spine is frequently marked, and the patient is observed to put the hands upon the hips in rising from the chair, and sometimes in walking. If but one kidney is involved, or the liver, or spleen, we observe the slight flexure to one side, and the effort to save the part from the movement of muscles. Evi- dently the drawing forward of the shoulders-" winged scapula," is a symptom of similar import so far as the lungs or thoracic region is concerned. So certain is this, that with the marked falling forward of the STUDY OF DIAGNOSIS. · 73 ! shoulders, and separation of the scapula, one may be sure there is some disease in the thorax. The head drooped forward has a similar import, though this is sometimes an indication of a wrong of the sympathetic nervous system. + In irritative disease of the cerebrum, or of the organs of special sense the head is flexed, but in disease of the medulla oblongata, cerebellum, pons and crura, the head is drawn backwards. Forced extension, or head drawn backward, will be recollected as a prominent symptom in cerebro-spinal meningitis. In all these cases flexion and favoring the part in muscular movement are evidences of irritative disease, and indicate the treatment. First, remedies that influ- ence the affected part; and second, remedies that re- move excited innervation and circulation or functional activity. In another class of cases, we will find flexion from or opposite the affected part, and the position of the body," and muscular motion is such as to give support and moderate pressure. The evidence in this case is of im paired circulation, congestion, effusion, and enlarge- ment. It is safe to say that in the majority of these cases the remedies will be such as will give additional stimulus. If one will closely observe the movements of the ab- dominal muscles, they may determine conditions of dis ease in pelvis or abdomen. The careful, slight move- ment evidences disease of the pelvic viscera if especially marked below-the chylopoietic viscera, if especially marked above. The full abdominal walls, with slug- gish movement, evidences atonic disease and congestion. If we examine with reference to the thorax, we will 7 74 STUDY OF DIAGNOSIS. find that free movement of the abdominal muscles and diaphragm, and but slight movement of the upper thorax, is evidence of disease of the upper lobes of the lungs. On the contrary, thoracic respiration, with but slight and careful movement of the abdominal muscles, evidences disease of stomach or liver. We have already examined the expression of the face sufficiently, and the movements of the muscles do not give much additional evidence. Twitching of the muscles is an unpleasant expression, and indicates un- due spinal irritation, or irritation of the basilar brain, the cause being frequently extrinsic. If of the mouth, our attention is directed to the abdominal organs; if of the upper lip and face, to the stomach; if of the nose, to the lungs; and if of the eyes and forehead to the brain and spinal cord. The quick, involuntary movement of the eyes, refers us at once to the excito-motor nervous system, and at once we make an examination to determine the source of the lesion, its cause, and adopt means to prevent its further progress, and convulsions. The forced con traction of one of the muscles of the eyeballs, turning them upwards, downwards, to one side, or causing stra- bismus, evidences disease of the brain, which may or may not be associated with wrong of the spinal cord. The character of the disease may be determined by the expression of the eyes and associate muscles, or by other symptoms. In diseases of children we will notice that sudden contraction of muscles and movement of parts is a pre- cursor of convulsions. The quick movement of the hand, with contraction of the fingers, the quick move. ment of the lower extremities, with forced flexion, or STUDY OF DIAGNOSIS. 75 the quick movement of the head upon the pillow, or the sharp, jerking movement of the shoulder, should never be neglected. This is but a mere outline of the subject, yet if it stimulates to observation, pointing out the way, it will serve its purpose. It is something one must learn from observation, and not simply store up in the memory. Indeed, unless the senses can be trained with the memory of facts, but little benefit will follow. COLOR OF THE SURFACE. As has already been named, the education of the eyes to distinguish colors, is of much importance in diag- nosis; and the reasons will be obvious to the reader. There is no property of living bodies so sensitive as color. It is usually thought of as evanescent, change- able, fleeting, and the expressions of poetry in this re- gard, but represents the results of close observation. The florist is guided by it to a very considerable ex- tent. When he visits his green-houses in the morning, his eye closely scans the plants with reference to their health. Change of color, even so slight that it would not be noticed by an ordinary observer, is to him evi- dence of disease. He recognizes in change of color, the escape of gases from his flues, want of ventilation, a wrong in the temperature, the want of, or a wrong plant food, the presence of parasites, etc. He not only makes his "diagnosis" from change of color, but gives the prognosis as well. The farmer, without any special training, or knowing why, recognizes the wrong color in his plants, and 76 STUDY OF DIAGNOSIS. speaks of their sickly appearance. If he has been a close observer, there is a something about their expres- sion, and usually in their color, that tells him of the character of the wrong-from drouth, from wet, from too much heat, from cold, from atmospheric changes, from want of plant food, from excess of certain foods, or from a wrong kind. He recognizes the coming of blight, rust, mildew, and the various parasitic diseases, by these changes, before the diseases are fully de- veloped. These are familiar examples, and should prompt to diligent study on our part. For, if in the vegetable world, disease may be recognized in changes of color, should it not be a means of diagnosis in animals and man? And if so definite in determining the kind of disease in vegetable life, will it not be equally. definite in determining disease in man? It will be noticed further that color has reference to the life; to the life of the blood, to the nutrition of tissue, to the oxygenation and decarbonization of the blood, and to the waste and excretion. Even here the popular expression should have stimu- lated professional inquiry-he has a healthy color - what is the color of health? he has a sickly appearance, what is a sickly color? If the popular mind recognizes. health in color, and disease in color, is it not well that we should make a careful study of it? Color in man has two sources-a, from the blood; b, from pigment—and it is well to distinguish these. In the first case the changes of color are referred to wrongs of the blood; in the second they are referred to changes in the quantity or character of the pigmentary matter of the body. A simple division would be into--a, color STUDY OF DIAGNOSIS. 77 which has red for a basis; b, color which lacks red, is a shade of yellow, brown, black.. In making examinations with reference to the blood, we select parts where the circulation is free and the epidermis or epithelium is thin-where the skin is thin, and the mucous membranes delicate. We examine the nails, the lips, the cheeks, the hands, scmetimes the feet, the tongue, and mucous membranes of the mouth. What is the color of health as shown from the blood? It is rosy, a light shade of carmine and lake, and is clear, transparent, and offers no darkness, or admixture with blue, purple, or brown. As the finger is pressed upon the surface, or pressed over it, toward the heart, the rosy color is removed, leaving the structures clear and transparent, and the color comes back quickly when the pressure ceases. It is difficult to describe color in words, but if the reader will now make his examina- tions of health he may readily learn to distinguish the color of health. The shade of rose color in mucous membranes differs somewhat from the skin, because it is modified to some extent by the pigment in the rete-mucosum. It is well to get a clear idea of it by examinations of the lips, the tongue, the mucous membranes of the mouth, and fauces. The color of mucous membranes is quite changeable to a slight degree, even in health, having shades of blue, violet, white, probably from the secre- tions of the mouth, and the food and drink; and we never regard these slight variations as diagnostic. The pigment color of health varies in different races, and in different individuals. But if we say it is some- what transparent and clean, we may express its char- cter for all races. If we take a negro for example, we > + 78. STUDY OF DIAGNOSIS. will find the jetty black has a transparency and clean- ness-glossy and smooth, which will be readily recog- nized. Let this man become sick, and the color grows dingy and opaque. If we take the olive or brown skin, the same cleanness and clearness of color is marked, and it seems so transparent that you may almost look into the skin. If you take the Caucassian, the brunette will show the same clearness in the skin pigment, and in the healthy blonde it seems as if you could look quite through the skin, it is so transparent. We may even notice these peculiarities in the color of the hair, as it shows health and disease like other parts, but modified more by local conditions. In studying color, especially that given by the pres- ence of blood, it is well to note that it may be changed in quantity (so to speak), and in kind. Change in quantity has reference to an increased circulation, and an increased amount of blood in the capillaries; change in kind, to the condition of the blood. Simple excess may be noticed from any cause increas- ing the circulation to the surface, or to a part. We ob- serve this excess of color in slight acute diseases, where the activity of the heart is increased, and there is gen- eral vascular excitement. It is not an unpleasant symptom, and points clearly to the arterial sedatives, Aconite and Veratrum, as the special remedies. If a part of the surface shows this excess, we at once think of its relation to internal organs and functions. If of the upper portion of the face and eyes, we refer the wrong to the brain. If of the cheeks, one or both, we refer it to the respiratory organs or apparatus of circulation. If of the mouth and lower part of the face, we refer it to the abdominal viscera. STUDY OF DIAGNOSIS. 79 As the excess refers to vascular excitement, and means general sedatives, so these local excesses mean local vascular excitement and local sedatives if we have them. Thus for the brain it would mean Gelseminum ; for the thoracic organs, Veratrum; for the abdominal viscera, Aconite, Ipecac, etc. It is well to note the condition of the capillaries in this examination, and we may determine somewhat of their condition by the effects of pressure. If the capil laries are in normal condition, pressure should efface the redness, but it is but momentary. If the finger is drawn across the reddened surface we notice the white line made by displacing the blood, but it rapidly passes away, and the blood flows quickly in and fills the ves- sels. If now we examine the redness in scarlet fever in the same way, we will find that the fingers carried over the part with pressure, effaces the redness, and leaves a distinct white line, more or less persistent, as the fever is severe. This shows enfeeblement of the capillary circulation, especially from the arterial side, and is an indication for Belladonna. In the larger number of cases, Aconite is the arterial sedative. The next best remedy to Bella donna is the Carbonate or Hydrochlorate of Ammonia. If the capillary wrong is from venous obstruction, the color will be deeper, and the wrong will be asso- ciated with fullness of cellular tissue in many cases, and the white line made by pressure is not so clear. In this case, Podophyllin, Lobelia, Bryonia, are reme- 'dies. We not only find an excess, as above named, but in other cases a defect in color, showing poor blood, leuco- cythæmia, or an impaired circulation to the surface. The 80 STUDY OF DIAGNOSIS. pallor of anæmia is shown in all-parts of the busty, and is associated with evidence of impaired nutrition. In the rare pathological condition, leucocythæmia, there is sometimes marked pallor, but usually it is disguised by increase or change in the pigment of the skin. In de- ficient circulation to the surface, we have want of color, but no evidence of want of blood in totality, or impaired nutrition. Deepening of color-dark red-is usually associated with zymosis, and has reference to sepsis of the blood. It is associated with asthenia, and when observed it tells of impaired function But it especially shows the need of acids, and in this respect refers to a direct remedy. It makes no difference where we find it most marked, its meaning is quite the same, of course modi- fied to some extent by local disease. • If the reader will think for a moment of the cases he has seen presenting deep redness of the surface, he will recognize the truth of these statements. In typhus fever, the gravity of the disease is shown by the flushed skin-dark-red. If in smallpox, we find the skin assuming this dark-red color, we are confident the dis- ease will be severe, showing depravation of the blood, and marked asthenia. If we observe it in measles, we anticipate trouble from tardy appearance of the erup- tion, depravation of the blood, respiratory trouble, and impairment of function. If seen in pneumonia, it talks to us of approaching "typhoid symptoms," of a low grade of inflammation, and great prostration. So clear is the evidence, and so rare the exceptions, that it be- comes one of the most reliable evidences of disease we possess. The meaning is modified to a certain extent by the STUDY OF DIAGNOSIS. 81 + results of pressure-whether the color is solid and un- yielding as the finger is pressed over the surface-or whether it is effaced by such pressure as heretofore named in simple excess. In the first case it has refer- ence wholly to the lesion of the blood, in the other in part to the lesion of circulation-at least the evidence is less grave. If the dark redness is an evidence of zymosis-sepsis -it speaks directly of antiseptics as a necessary part of the treatment. It says clearly-this patient must be kept clean, his clothing and the bed-clothing must be frequently changed, and kept clean and sweet, all the surroundings must be clean, he must have good air, fre- quently changed by good ventilation. It means further, that proper means shall be employed for disinfection when this becomes necessary. If the dark-redness is associated with asthenia and impairment of life, and gives us timely warning of such impairment, it will caution us against the use of all de- pressant remedies, or anything that will impair any of the important functions of the body. And it suggests the necessity of keeping the stomach in condition to receive food, and the proper selection and preparation of food during the progress of the disease. But it directly refers to acids as remedies, and this is of much importance. Acids here are the antiseptics and antizymotics. We give Muriatic Acid, Acetic Acid in the form of good cider, and Lactic Acid in the form of whey, and we find the condition of the patient markedly improved. Muriatic Acid is especially the antiseptic, though the others have an influence in this direction. The dull purple (bluish) of venous blood has reference 82 STUDY OF DIAGNOSIS. to imperfect venous circulation, and imperfect decarbon- ization of the blood. It may be caused by disease of heart or lungs; if not we recognize a lesion of sympa- thetic and associate spinal nervous systems. It evi- dences an unpleasant condition of life, and one that should be removed if possible. In some cases the dull- ness of color becomes so marked, that we designate it. as leaden. If we find local structural disease to account for it, this will receive our attention. If it is sudden, and associated with præcordial oppression and constriction. of the chest, Lobelia is the remedy. If less marked and chronic, we will think of Cactus, Digitalis and Pulsa- tilla. In acute cases, Chloroform counter-irritation around the lower margin of the thorax, gives speedy and marked relief. In the lesion of cholera we will find the blueness of hands and feet dependent upon enfeebled capillary cir- culation, the blood being loaded with carbonic acid gas. If the condition of the blood can be so changed, as to enable it to circulate, this passes off. This blue- ness with pallor is one of the most marked indications for common salt as a medicine. Want of color, with a shade of solid blue where the blood shows freely as under the nails, the lips, the cheeks, and thin skinned portions of the body, may be assumed to indicate the want of Iron. A violet tint with increase of redness uniformly, or only where the circulation is superficial, is a prominent indication for Nitric Acid. Deep color, with purplish, brown, or black tinge, is a prominent indication for Baptisia Color not deep, but muddy or dirty, of parts freely STUDY OF DIAGNOSIS. 83 supplied with blood, is an indication for Sulphurous Acid. If there is this dirty shade with pallor, we would use Sulphite of Soda. When we come to study the local changes of color referred to the blood, we divide them into two classes, the one in which the change is to be referred to a lesion of some other part-sympathetic; the other in which it is dependent upon local disease. The reader will notice that the significance of color must depend very much upon this, for whilst the one may have no refer- ence to the condition of the blood at large, or to any structural lesion, the other is wholly referred to the lesion of the structures, and to changes in the blood. We always want familiar examples to show that a method of study is likely to prove advantageous—that is a basis of fact, and we will adduce the three familiar cases of change in the color of areola of the nipple, the dark line under the eyes in certain conditions of women, and the white line around the mouth in some intestinal diseases of children. In Every practitioner will have noticed the darkened areola of the nipple as an evidence of pregnancy, but may not have had his attention called to it as an evi- dence of disease of the reproductive function. wrongs of this function simulating spermatorrhoea, we will find this change of color marked, as we will in scanty menstruation with congestion, and in hyper- trophy of the cervix uteri. Of course we do not look for this, except in the diagnosis of pregnancy, but in this case it is one of the most valuable symptoms. If you should notice the deep color under or around the eyes in women, you would say at once there was a wrong of the reproductive organs or function, and you 84 STUDY OF DIAGNOSIS. would rarely make a mistake. If the tissues seemed dry, the eyelids sunken and contracted, it would be safe to say that the disease was one of irritation, and would probably be relieved by Pulsatilla and Macrotys, (especially if functional.) And if the eyelids were full, swollen, relaxed, that the disease was of congestion or atony, and would be benefited by Hamamelis, Apc- cynum, Staphysagria, Phosphorus, Iron, etc. Many cases present themselves where we do not wish to suggest an examination of the reproductive organs at first, or there may be some reason why it should not be made at present, hence the importance of other means of knowing the character of the wrong, and the class of remedies we may select from. If one should notice the white line around the mouth, with full pallid upper lip, full or contracted mouth, he would at once refer the symptom to a wrong of the gastro-intestinal apparatus. The reference is undoubt edly right, if we except the rare case in which the symptom is dependent upon lesion of the brain. There is a wrong of the stomach and bowels. What is the character of that wrong? If the structures are full, it is pretty surely one of atony-a want of innervation and a sluggish circulation. If the structures are con- stricted and pinched, the wrong is very certainly one of irritation, excited innervation and circulation. Is it worth our while to read the evidences of disease in the patient's face? I think it is, especially when the remedies are at once suggested. The white line around the mouth-gastro-intestinal disease. With fullness of tissue-Podophyllin, Hydrastia, Santonine. With con- striction and thinning of structures-Aconite, Ipecac. But suppose we notice a peculiar bluish or leaden STUDY OF DIAGNOSIS. 85 : tint to this white line around the mouth, and see a slight dragging down of the corners, we would recog- nize the gastro-intestinal lesion-remedy, Bismuth, or sometimes minute doses of Arsenic. Increased color of cheeks has been noticed as a symp- tom of thoracic disease for thousands of years. What relation has this flushing of cheek to the condition of the lungs? Can you explain the nervous and vascular connections? Evidently we can not tell why, and I doubt if the evidence would be any more valuable if we could tell why. This is one of many examples that the interrogatory-why? is not always a profitable study in medicine. We know the fact, that a habitual recurring flush of one or both cheeks has reference to an irritable or discased lung. The persistent high color, even though it be a distinctly circumscribed spot, has a different meaning. If we notice this circumscribed flushing of the checks, our attention is at once attracted to the re- spiratory apparatus. Associated with frequency of pulse and increased temperature, it tells us of com- mencing tubercular deposit. In this case the one cheek is usually flushed. It may be remarked further, that this symptom is always associated with a wrong of the sympathetic nervous system, especially in its relation to circulation and nutrition, and in phthisis we only find the bright, flushed cheek with irritation. Sometimes there is quite as marked pallor, and the evidence would be a want of innervation. The bright-red flush of left cheek in acute disease is usually referred to thoracic disease, but does not always indicate it. It evidences a lesion of sympathetic and 86 STUDY OF DIAGNOSIS. t spinal innervation, but is especially valuable as calling our attention to Rhus Toxicodendron as the probable remedy. The deeper flush of right cheek is more frequently seen in disease of serous membranes and fibrous tissues, but is especially valuable because it points out Bryonia as the probable specific remedy. Whilst the bright color of the cheeks, where it has reference to disease of the respiratory organs, tells us of irritation and activity of circulation, deep color in- dicates impairment of the circulation and of the life. The livid, purplish color in some cases of angina pec- toris, may be taken as the type. We have it in much less degree in thoracic ancurism, in apoplexy of lungs, and in some very severe cases of asthma with conges- tion. The dark redness is always evidence of a difficult and imperfect circulation. There is a pinkish color of parts freely supplied with blood, that is regarded by some as an unpleasant symp- tom. As this color becomes more pronounced, we ob serve it in the veins as well. In women we may usually refer it to a menstrual wrong, which will be corrected by the use of small doses of Pulsatilla, Actea Alba, Helonias. For the chronic lesion we think of Phos- phorus, the Hypophosphites, the bitter stomachics, and food. Among the things that old women know 18--that prominent blue veins crossing the nose in children is a sign of feeble vitality, and it is quite as true as if a phy- sician knew it. There is something wrong in the life. when you observe these cutaneous veins showing the distinct and constant blue line, whether it is across the nose, at the wrists, upon the back of the hand, over the STUDY OF DIAGNOSIS. 87 breast or abdomen, or elsewhere. Whilst it may not point out any special medicine, it does prompt us to ad- vise that the child have abundant out-door exercise, good blood-making food, and that it shall not commence study early, or be much confined until there is a much stronger and robust life. Unusual blueness of veins is a very good indication for Iron. If associated with pallor of surface, we may select Iron by Hydrogen, or Valett's mass, but if there be deep color of tongue, Tincture of Muriate of Iron. The color of the conjunctiva and sclerotic will some times give us information in regard to the circulation of the brain. If we find an injected conjunctiva (not the result of local disease), we conclude that the cere bral circulation is similarly affected. If the color is bright, and the surface looks smooth and moist, we have evidence of determination of blood. If the color is deep and the surface looks dull and dingy, or dry and pinched, it represents hyperæmia, with obstruction to the return of blood-the apoplectic condition. The dull, colorless eye is the best indication for Belladonna, though we use it when the eye is injected, with tortucus vessels. In superficial disease, the color of the part is a means of determining its condition, If we take the ordinary symptoms of inflammation, increased color-redness-is one of the first named as constant. Given increased color, with heat, pain and swelling, and we say there is inflammation; but which of these will best tell us the real condition of the part? I should answer, color. If the color is bright, healthy red, we know at once that the inflammation is simple, and is not very likely to work a very great wrong to the part, or to the body 88 STUDY OF DIAGNOSIS. at large. It tells us of irritation, determination of blood, and of activity of circulation; the second part of the wrong of circulation-stasis-is in but small pro- portion. It says, give general arterial sedatives, use local sedatives, get rid of increased heat, and establish secretion. The evidence is quite the same, whether we are looking directly at the inflamed part, or at some distant surface, that is influenced by sympathy. If the color is deep-red and dull, we are confident there is marked impairment of life and arrest of circu- lation. The fact that there is too much blood in the part is evident, that the capillaries are enfeebled, and the circulation in them is sluggish or arrested, that change has commenced in the stagnant blood, and that the life of the part will be destroyed, unless these wrongs are corrected. It says distinctly, strengthen the general circulation, whilst you lessen its frequency, and conserve and sustain the life of the blood by rest and food. If a local application is to be made, it is now stimulant—we want to strengthen the life of the part. If we select an internal remedy that is to influence the part from the blood, this remedy must be stimulant or tonic in its character. If the part assumes a blue or purplish color we recog- nize venous stasis, and an obstruction to the circulation from the part. With our attention called to the nature of the wrong, we will find its cause and remove it if possible. My attention was first called to this evidence of venous obstruction in a case of fracture of the fore- arm, with laceration of the hand, in which a roller was applied before the splints, yet not very tight. Inflam- mation sprang up in the hand, and the third day came this bluish discoloration, with a great deal of local STUDY OF DIAGNOSIS. 89 trouble. The roller was removed, and the difficulty slowly passed away. I have seen the same wrong arise from the position of an extremity being such as to im- pede the circulation of blood. In some cases the wrong being general, venous im- pairment is cardiac. We do not know why, but we rarely find an impairment of the right heart, when the left is sufficient for the systemic circulation. Lobelia in stimulant doses exerts a very favorable influence in these cases. If there is fullness of cellular tissue, Apocynum may be associated with it, or given alone. If the wrong is from venous impairment, and is chronic, Hamamelis is probably the remedy. The erysipelatous redness is so distinctive, that being once seen it can hardly be forgotten. The vivid color- ation, evident dryness, shining appearance, give the be- holder a sense of burning. It makes no difference so far as the significance of this coloration is concerned, whether we have the local inflammation of the skin or not, it refers us to a lesion of the blood, zymotic in character. If the surgeon find this tint of vivid red- ness on the edges of a wound, or the flaps of an ampu- tation, he would be at once on the alert to get rid of the lesion of the blood. If the physician observed this erysipelatous flush on the cheek in inflammation of the lungs, or any where on the surface during the progress of an inflammation or fever, he might feel sure he would have a more than usually serious case to manage. We may distinguish four shades of this erysipelatous redness quite well marked in many cases, pointing out the remedies for the disease of the blood, and the locaì inflammation. In the first the redness is quite vivid, and the edges of the local disease show a simple erythe- 8 90 STUDY OF DIAGNOSIS. 1 matous flush, and the part does not look dry and con- stricted. Sometimes there is arterial throbbing of the part, and the pulse is full. In this case Veratrum is the general and topical remedy. In the second case the redness is very vivid, and the parts dry and constricted, with sometimes the appearance of a slight pustular eruption. The pulse is small, sharp, vibratile; the remedy is Rhus Toxicodendron. In the third case the redness has a deeper shade, sometimes vivid, sometimes dull. The remedy, both general and local, is Tincture of Muriate of Iron. The fourth case shows more or less of a blanched appearance, as the disease advances : sometimes in the centre, sometimes at the borders, sometimes of the deep structures—you seem to be look- ing through the superficial redness. In these cases the general remedy is Sulphite of Soda, the local remedy Sulphurous Acid, Permanganate of Potash, or Carbolic Acid. The variations of pigment color in different individ uals is so great in health, that it might seem almost im- possible to get definite information from its variations in disease, yet I think we will find it quite as certain as other evidences of disease. Of course we must have a correct idea of normal pigment coloration, and some guide to the natural tint of the individual. Transpa- rency and cleanness are the characteristics of health, whatever may be the shade. The lesions might be divided into those of excess, defect and perversion, though the last is the most important. Excess of pigment, when it retains the clearness and transparency of health, is usually evidence of active life, and good nutrition and excretion. Of course out- door exposure is always taken into consideration, as ! STUDY OF DIAGNOSIS. 91 • causing an increase of pigment. Local excesses of pigment have a variable meaning, though if still clear and transparent we think of functional activity. If we take the areola of the nipple, the clean, transparent, deep color evidences healthy gestation, as does the deepened color over the gland. The increase of abdom- inal pigment has the same meaning, as has the increased pigment color of the vulva. Even the increased pig- ment of face observed during gestation is an index of healthy function. Not so the unequal and unpleasant brownish coloration known as morph. The deep pigment coloration of the neck in brain workers is a sign of healthy nutrition of the nerve centres, whilst the want of pigment would indicate anæmia, and the dirty pigment would show a wrong of nutrition. The coloration of the skin and hair have the same associations. The clear, transparent color is the evi- dence of health, especially of the skin. The deepened color is evidence of an active life, especially of the vege- tative functions; whilst a loss of color is at once re- ferred to impaired nutrition. Even the color of the hair is subject to slight changes, and one may learn to distinguish by this the condition of the nutritive func- tions. It is an unpleasant sign to find the hair becom- ing dull and sickly in color. There is an increase of pigment distinctly brown, and in patches on various parts of the body, which is known as "liver spots." They generally make their appearance on parts covered by the clothing, and may be quite large and extensive. We refer them to a wrong of the bile pigment, and frequently find it asso- ciated with a wrong of digestion, and impairment of 92 STUDY OF DIAGNOSIS. \ the function of the brain. The remedy is Podophyllin, associated with its natural bitter principle, Bebeerina, (Hydrastia). The brownish-yellow coloration is evidence of a wrong of the organs of digestion. We may find it only about the mouth or the face, or we may find it pretty general where the lesion is chronic. It refers us to Nux Vomica as the remedy. Give us the same color, but dull and opaque, or with a leaden tinge of adjacent skin, and we again refer it to a lesion of the organs of digestion. The remedy is Chelidonium; Podophyllin, if the tissues show more than usual fullness. The bright yellow of jaundice is a symptom of wrong of the liver. What the condition of the liver may be, other symptoms must decide. But in so far as the color is concerned, we expect to wash it out through the kidneys. There is a peculiar sallowness with a tinge of green that indicates great impairment of blood-making and nutrition. The remedy is Copper; we usually give Rademacher's Tincture. No one could mistake the opaque, tallow-like color of hypochondria, and associate states. It tells us of impairment of the digestive and blood-making organs, of nutrition, and of waste and excretion. There is a slow renewal of life, and the tissues are old and feeble. Very clearly in this case we want a more active "re- newal of life," and we stimulate the processes of retro- grade metamorphosis and excretion on the one hand, to remove the old structures, and see that the function of digestion is well performed, that we may have in- creased nutrition. 1 STUDY OF DIAGNOSIS. 93 One could hardly mistake the evidence of the dingy, dull, grimy, dirty color of skin. It refers us to a wrong of the blood-" bad blood," and we conclude that the blood is as dirty as the skin. Of course it would not do to mistake the dingy, dirty skin of the “great un- washed," but this is not very likely. Soap and water will show the difference. In this case remedies to in- crease secretion, and sometimes to promote retrograde metamorphosis, hold the first place, though we do not forget the importance of improved nutrition. There is a deepened tint of skin, dull and opaque, that is a very good indication for Arsenic or Phos- phorus. The tissue seems to have lost life, and is in- elastic. Dullness of color and opacity, may be regarded as the special features; and opacity where the color is lighter than usual may indicate the remedy. If we have a distinct want of pigment, the want of color not dependent upon anæmia, or an enfeebled cir- culation of blood, we think of Sulphur as a possible re- storative. Given in small doses, we sometimes find it exerting a marked influence upon the nutritive pro- cesses. 毋 ​EXAMINATION OF THE TONGUE. "Let me see your tongue," says the doctor at every visit, though what he expects to learn from "seeing the tongue" he would be puzzled to tell you, unless it was that the patient was "bilious." Of course habitu- ally seeing the tongue in disease will, unconsciously, many times, grow some knowledge of its diagnostic value, and if the physician is a close observer, it will give him valuable aid in determining the character of 94 STUDY OF DIAGNOSIS. ནཱ་ disease. But many men are so little in the habit of using their eyes, and thinking for themselves, that they learn but very little. If we think for a moment, we will see that the tongue may tell us of-a, the condition of the digestive appa- ratus; b. the condition of the blood; c, the condition of the nervous system and d, of the functions of nutri- tion and excretion. As these are important inquiries, indeed just the things we want to know, we will make the tongue talk as plainly as possible. We find the expression of disease in-a, its form; b, its condition of dryness or moisture; c, its coatings; d, its color; and e, its motion. It is well to think of the subject in this methodical way, even though we are not able to follow it wholly in this study. The common idea of physicians is, that the tongue expresses the condition of the stomach and intestinal tract, and it should be examined with reference to this; few think that it may give further information. Being a part of the digestive tract, supplied by the same nerves, and invested by the same mucous membrane, we would naturally expect it to show something of the condition of parts below. If we say that its condition may be taken as the type of the condition of parts below, we will not be far out of the way. True, there are many exceptions, but the rule is a very good one, and will hardly lead to serious error. The mind at once recognizes the changes of form, movement, condition, color, and secretion, as ex- pressions of local disease. It will not be far wrong, if it recognizes them as expressions of disease of the entire digestive apparatus. Change of form is quite expressive, and rarely leads STUDY OF DIAGNOSIS. 95 us into error. The elongated and pointed tongue ex- presses the condition of irritation and determination of blood to stomach and intestinal canal very distinctly, and it is safe practice to give it full weight, and be very careful in the administration of remedies. As it is associated with excitation of the nerve centres, this is to be taken into consideration, when we value the evi- dence with reference to the stomach and bowels. If we observe this change of form early in the disease, we not only anticipate unpleasant gastric irritation through the sickness, and use care in avoiding irritants, but we employ means to remove it. Among these may be named minute doses of Aconite, Ipecac, Hydrocyanic Acid, Peach-bark infusion, small doses of Rhubarb, and Bismuth. The full tongue, broad and thick, is the evidence of atony of the digestive tract, especially of the mucous membranes. In this case the stomach and intestinal canal tolerates the common medicines given, and the use of cathartics is less harmful, and may be more bene- ficial than in others. The pinched, shrunken tongue expresses a want of functional activity in the digestive apparatus. It is the tongue of advanced acute disease, and is usually asso- ciated with dryness. "Want of functional activity" hardly expresses the condition, for the life of the diges- tive apparatus has suffered to such an extent, that there can be but little function. Whilst it is one of the indi- cations of want of food, it causes us to be very careful in its selection and administration, giving small quan- tities at a time, and at such periods as the unpleasant symptoms are least marked. The fissured tongue in chronic disease points us to 96 STUDY OF DIAGNOSIS. 1 lesion of the kidneys inflammatory in character. In some cases the fissures are transverse only, but in severe cases, they are somewhat irregular, and by pressing the tongue down it is seen to separate in irregular patches. of prominent villi. The symptom is so definite, that one may be assured of inflammation when this tongue presents. The fissured tongue in the advanced stage of febrile diseases refers us to lesion of the kidneys, or irritation of the nerve centres. In many cases we find a wrong in the secretion of urine, and close examination shows a.condition of kidneys bordering on inflammation. It deserves careful consideration, and especially means to place the skin in better condition, and to allay irrita- tion of the cerebro-spinal centres. The conditions of dryness and moisture are important evidences of the condition of the intestinal tract. If the tongue is dry, we are sure the stomach and intes- tinal canal can do but little digestive work, and we give it as much rest as possible. In such cases food is always given in fluid form, and usually above the temperature of 100°. It is also carefully selected and prepared, that the labor of digestion may be as small as possible. If the tongue is dry we are confident there is want of secretion from the intestinal canal and associate glands, and indeed that there is a condition present which will prevent the action of direct remedies to favor secretion. It is most absurd to employ cathartics in such cases, unless the object is simply to remove irritant accumula- tions. Moisture, on the contrary, expresses a condition favorable to functional activity. True, there may be impairment of function, as when the tongue is full showing atony, or heavily coated, showing increased STUDY OF DIAGNOSIS. 97 mucous secretion, or dirty, showing depravation of the blood and secretions. If in acute disease with dryness of the tongue, we observe it becoming moist, we are confident of improve- ment, of the establishment of secretion, and indeed of all the vegetative processes. Having this meaning, it is nearly always regarded as a favorable symptom. The coatings of the tongue are observed with care, as they are thought to be especially symptomatic of the condition of the digestive tract and the "liver."* *APPEARANCE OF THE TONGUE AS A SYMPTOM OF Disorder OF THE STOMACH -The aspect of the tongue was held by the older writers in medicine to be one of the most important criteria of the state of the digestive organs; and its morbid appearances were therefore carefully observed and minutely described by them as indications for both diagnosis and treatment In more recent periods, however, the value of the evidence furnished by this organ has been, if not entirely denied, at least so greatly depreciated, that it seems desirable to ascertain what are the limits of our knowledge with regard to the association of changes on its surface with those occurring in lower portions of the alimentary canal. The question appears to be capable of being resolved into three principal divisions: 1. What are the nature and causes of the alterations in the tongue which have been regarded as diagnostic of affections of the stomach? 2. In what other diseases, occurring independently of stomach affections, are these changes observed ? 3. What is the nature of the alterations of the digestive organs with which these conditions of the tongue bave been found to be associated ? The appearances of the tongue which have been most com. monly believed to be associated with the diseases of the rest of the intestinal canal, are (a) an increase of its epithelial covering 9 .t 1 98 STUDY OF DIAGNOSIS. Whilst there is much of error in the common ideas of "furred tongue," something valuable may be learned. The vivid whiteness of the tongue, evidently a change in the epithelium, evidences simple functional wróng, and is associated with the febrile state. If observed at other times, it may be taken as an indication that the stomach and digestive tube want rest. The thin, transparent mucoid coating of the tongue, evidently upon and from the secretions of the mouth, evidence enfeebled, digestive function, frequently from intemperate eating or drinking. or "fur," which may present various degrees of thickness, and different shades of color; (b) enlargement of its pa pil; (clæ) various shades and degrees of redness of the mucous membrane; and (d) certain alterations in its size and shape. ► (1) The fur or coating (saburra) has been shown by micro- scopic examination to consist of epithelium scales, which are often fattily degenerated, and sometimes massed together, of free fat drops, and of confervoid growths; of these the largest pro- portion is formed of the epithelial cells which are derived from the covering of the organ together with the saliva and buccal mucus, which in drying form a thick glutinous material, con- glomerating the other elements into a mass. The fur may be of greater or less thickness, dry or moist, uni- form, or accumulated more particularly at the posterior portions. it is sometimes deeply fissured by sulci, which may extend into the mucous membrane beneath. At other times it may separate in flakes from the surface, which then may look raw, and of a deeper red than natural, but which may, when the process of separation is gradual, present no deviation from the norma¹ appearance. Mixed with the fur may be sometimes found pigment, blood corpuscles, mucous or pus corpuscles, or the remains of vegetable and animal portions of food. STUDY OF DIAGNOSIS. 99 The fur which has consistence is evidently upon the tongue, and can be scraped off-evidences impairment of function, and the wrong is generally in proportion to its thickness. If uniformly distributed it may be regarded as having reference to the entire intestinal tract; if restricted principally to the base, we think of greater wrong of the stomach. The heavily loaded tongue would call our attention to accumulations in the bowels, and would prompt to means (mild) to secure their evacuation. The heavily loaded tongue at the baso calls attention to accumulations in the stomach, and The color may be white or milky, or may present various shades of yellow or brown. The nature and cause of some of the changes in color are very imperfectly understood. Some of them arise from articles of food, medicinal substances, tobacco, etc.; a large proportion, how- ever, are caused by slight hemorrhages from the gums; while some others, and especially those occurring in fevers, remain un- explained. Excepting, however, those cases where there is direct pigmentary discoloration from jaundice, when other tissues par. ticipate in the change, there is no foundation for the common belief that a yellow fur on the tongue has any necessary connec- tion with hepatic disorder. As regards the chief causes to which the production of this fur is attributable, may be mentioned: (a) Idiopathic conditions in which the tongue of some persons may, consistently with apparently perfect general health, form and throw off a much larger amount of epithelial covering than is ordinarily the case; inquiry should, therefore, be directed tc this point before any general conclusions are formed respecting the indications to be drawn from its presence. (b) States in which a coating is formed on the tongue by the simple drying of inspissated mucus and saliva, owing to the mouth being kept open, as is often the case during sleep. (c) Conditions of irritation in the mouth itself, giving rise to Bork 100 STUDY OF DIAGNOSIS. г 1 suggests the use of an emetic to free this viscus, and stimulate normal innervation and circulation. Yellowness of coating is thought to arise from wrong in the hepatic function, and to point to the use of "liver remedies." Whilst it may have this reference in some cases, it is well to avoid the usual cholagogues. It may be said to call for Nux Vomica, small doses of Podo- phyllin and Hydrastine. A dull, leaden, yellow fur is an indication for Chelidonium. A dull, cheesy look- an increased production of epithelium on the cheeks, gums and tongue, and which, from their similarity to the state of other mucous membranes, where increased secretion, attended with shedding of the epithe.ial covering, is the result of irritation or subacute inflammatory action, are usually termed catarrhal. The belief that this is the true pathology of this state, is also favored by the coincidence, in many such cases, either of a gen- eral redness of the surface, beneath the thickened epithelium, or of hyperemia and enlargement of the papillæ, especially of the papillæ fungiformes of the lateral and anterior portions. In some instances, also, the inflammatory state is further evidenced by the production of aphthæ, giving rise to slight and superficial ulcerations, with a reddened base, and often surrounded by a reddened margin. Many of those conditions of the tongue may, however, be due to local causes, such as carious teeth, or other sources of irritation to the fifth nerve, or to accumulation of food around the bases of the teeth, or to medicinal agents affecting the salivary glands and mouth, as Iodide of Potassium and Mercury, or to the habit of smoking (though this does not ordinarily produce a thickened epithelial fur, nor hyperemia of the papillæ fungiformes, its effects being generally limited to an enlargement of the papillæ filiformes, which gives to the surface a finely roughened aspect). As smoking, however, is not an unfrequent cause of stomach affections, our observations on this head are always attended with certain grounds of fallacy.-Fox on Diseases of Stomach. STUDY OF DIAGNOSIS. 101 ing fur, with slight green tinge, is an indication for Copper. The bright redness of tip and edges, especially of papillæ is an evidence of irritation with determination of blood. It always suggests care in the use of reme- dies, rest to the stomach, and the special agents named to remove irritation. A good condition of stomach is of first importance in the treatment of disease, and when these symptoms present, these means will hold a prominent place. The tongue gives us the best evidence of the condi- tion of the blood, and of the remedies which rectify its wrongs. All exudations or secretions from the blood must give information of the character of this fluid, and there is no better place to observe them than in the mouth. The circulation of blood is also very free and superficial in the tongue, and we are thus enabled to observe its changes of color better than in other situa tions. The reader will recollect the distinction between the tongue itself and the fur or coating, when color is spoken of, as the one is from the circulating blood, and the other from the exudation. The broad, pallid tongue-marked want of color in the tongue itself-evidences the want of the alkaline elements of the body. The evidence is clear and dis- tinct, and the want one of much importance. It may be the basis of the entirety of the disease, which will fade away as soon as the proper alkali iş given, or it may be but a portion of the wrong, and the alkaline salt prepares the way and facilitates the action of other remedies. If there is no special indication for some other, we prescribe Soda because it is the salt of the blood. 102 STUDY OF DIAGNOSIS. Usually we direct the bicarbonate added to water to make a pleasant drink, and given freely as the patient wishes it. If there is predominant wrong of the mus- cular system, we may select a salt of Potash. If of the cellular tissue, a salt of Lime. The deep red tongue, (usually contracted and dry) evidences the want of an acid, as well as that condition of the blood known as "typhoid." Here, as in the preceding case, the want of an acid (undue alkalinity of blood), may be the principal element of disease, and all the symptoms are ameliorated, and the patient con- valesces when it is given. In other cases it is but a por- tion of the disease, and the acid facilitates the action of other remedies. It is a very co It is a very common symptom in typhoid and typhus fevers, and the use of an acid in these cases has been found a very successful treatment by Chambers, Anstie and others in the London Hospi- tals. Our Prof. King, some twenty-five years since, suggested the use of good sharp cider in these cases, and it has been employed with much success. He did not say there was deep redness of mucous membranes, but he might have said so, for he did name the dry and contracted tongue with dark sordes, and they are asso- ciated together. In this case we select with reference to the condition of the stomach, and the blood poisoning, and some- times we may defer to the taste of the patient. Muri- atic Acid usually receives the preference, as it is well borne by the stomach, is a natural acid, and is a power- ful antiseptic. It is added to water to make a pleasant acid drink, and given ad libitum. In some cases sharp cider is better borne by the stomach, is grateful to the taste, and the small amount of alcohol in it is beneficial. STUDY OF DIAGNÓSIS. 103 In others lactic acid, in the form of whey, answers an excellent purpose, as it furnishes a calorifacient food as well. The deep red, or deep violet colored mucous mem branes, with fullness, evidences sepsis, and is an indica- tion for the special remedy, Baptisia. The acid should also be given in some cases. The full color, with violet shade, superficial and trans- parent, is the indication for Nitric Acid, and it will be found one of the most valuable remedies of the Materia Medica. The tongue large, thick in centre, with incurved. edges, and of a dull blue, or leaden color, is one of the strongest indications for Arsenic, and it will rarely fail to arrest the progress of disease in such cases. The same dull, leaden color, with no change in size or shape of the tongue, is one of the best indications for the use of Phosphorus, or the Hypophosphites. The slick, raw-beef tongue, the papilla wholly effaced, evidences sepsis of the blood, and is one of the most. marked of the "typhoid" symptoms. The color of the tongue is usually deep, and we will employ an Acid or Baptisia. The exudation or fur upon the tongue is a pretty good index of the condition of the blood. Of course we must weigh the influence of local disease of the mouth and teeth, and the sympathetic relations with the stomach and bowels, as heretofore named. (See note.) The dirty fur is an indication of sepsis of the blood, as well as of depravation of the secretions. It is fre- quently associated with moisture, and the redness is rarely increased. We e use the common word "dirty," 104 STUDY OF DIAGNOSIS. because it expresses our meaning clearly-the impres sion upon the senses is that of dirt, and its meaning is dirt. It may be a dirty-white, a dirty-gray, a dirty- yellow, or a dirty-brown, but the dirty, grimy appear- ance always assumes prominence in the mind. If we have a dirty tongue, pallid, we usually think of Sulphite of Soda. If the redness is natural, we may use Sulphurous Acid or Sulphite of Magnesia. If dirty, with increased redness, Muriatic Acid. All shades of brown and black have reference to the condition known as typhoid. We have every shade of color from the slight tinge of brown to the deep brown or almost black. It is not only the coating of the tongue that shows this color, but accumulations of sordes about the teeth, and sometimes crusts upon the lips. As is the deepness of color, so is the wrong known. sepsis," and so is the need of the class of reme- dies known as "antiseptic." As is the deepness of color, so is the impairment of life, and the need of care and rest to conserve it, and of food and restoratives to support it. as "" These dark coatings are so usually associated with deep redness, that we usually think of acid remedies, first of which is Muriatic Acid. But some of the cases will need Baptisia, others Chlorate of Potash, and some will be benefited by Carbolic Acid. Cleanliness is of especial importance in these cases, as all decomposing animal matter in the air or surroundings, increases the wrong of the blood. The reader may not have thought that the tongue could tell him much with regard to the condition of the nervous system, and yet a little study will show that it does give very important evidence. It has STUDY OF DIAGNOSIS. 105 1 special reference to the condition of the sympathetic nervous system, and this may be regarded as the most important, but we also learn much of cerebro-spinal in- aervation. We associate dryness of tongue with excitation of the nerve centres, especially the ganglionic. So positive is the evidence that it is not possible to mistake it. Dry- ness of tongue is associated with vascular excitement, and with arrest of secretion from this cause. If in acute disease with dryness of tongue, we find it becom- ing moist, we know that the nerve centres are being re- lieved, and that the circulation is improved, and secre- tion is commencing. If in a case of disease marked by enfeebled innervation from the sympathetic, and moist, relaxed tongue, the tongue commences to dry and be- comes firmer, we know that this nervous system has been stimulated, and many times it is a first evidence of amendment. Whilst dryness always evidences undue excitement of the nerve centres, and calls for sedatives, or that class of agents which remove this, too much moisture and relaxation is evidence of the opposite condition. The reader will recollect the typical salivation from Mercury, and its influence in this regard, and will weigh the de- pressant influence of the mineral upon the sympathetic nervous system, by these conditions. If after miercu- rial salivation, the nerve centres are stimulated by Quinine, or Quinine and Opium with Ipecac, the tongue will become firmer and may become dry, and if not too great, this has been regarded as a good symptom Moisture of tongue is one of the prominent conditions assuring us of the kindly action of Quinine, and even of Optum when indicated. If marked, and accompanied 106 STUDY OF DIAGNOSIS. by full, relaxed tissues, the patient always requires nerve stimulants. Contraction is always an evidence of an excited nervous system. Sometimes, indeed, we may measure the wrong of innervation by this symptom, as in typhoid and typhus fevers, and in the later stages of acute dis- ease. The reader who has seen the great nervous wrongs of those affections, will recollect the pinched, contracted tongue as one of the prominent symptoms. Fullness of tongue has the opposite meaning. If marked, we are quite sure that innervation is impaired from atony, or want of normal stimulus of the nerve centres, especially of the sympathetic. It suggests nerve stimulants as a part of the treatment, Podophyl- lin and Lobelia for the solar and cardiac plexus, Nux Vomica, Strychnia, Belladonna, Ergot, for the associate sympathetic and spinal nervous systems, and Quinine for the associate wrong of the three, or simply for the brain alone. Whilst the elongated and pointed tongue has especial reference to the stomach and intestinal canal, it is one of the expressions of disease of the base of the brain. It is well to note this fact, for we may have the wrong of the brain as the primary lesion, the nausea and vom- iting being but the result, and if treatment was wholly directed to the stomach, we would make a great mis- take. Gelseminum assumes a prominent place here, associated either with Veratrum or Aconite. Rest is obtained by the topical action of Chloroform about the ear. The small tongue, full in the centre, which is covered with a thick, tenacious mucoid coat, is an indication of marked disturbance of the brain, unless we have evi- STUDY OF DIAGNOSIS. - 107 dence of acute disease of ears, the globes of the eyes, or the sphenoidal or ethmoidal cells. It may indicato a very grave lesion, or in the latter case will pass away with the local disease. In those cases where the coat- ing is removed, the surface is left slick, and very dark colored. The tongue covered with a grayish or yellowish fur, showing small patches of red distributed uniformly over the surface, is the tongue of scarlet fever. The same appearance will be seen in other cases, where the capillary circulation of the skin is enfeebled. The eroded appearance of the papilla at the tip of the tongue, looking like small, rose-colored bubbles, evidences a peculiar wrong of the nerve centres and of the blood, for which Rhus Toxicodendron is the remedy. The movements of the tongue are sometimes of im- portance in determining the condition of the brain. If the patient has complete command over it, we conclude that the functions of the brain are still well performed. But if it is protruded with difficulty, is tremulous, or is inclined constantly to one side, we are confident we have a proportionate cerebral lesion. Whilst we might get the evidence elsewhere, it is quite as well to give weight to these symptoms, and when observed, to adopt means early for the relief of the brain. From what has been said, the reader will draw the conclusion that impairment of nutrition and secretion. will be indicated by marked dryness and contraction on the one hand; or increased moisture and relaxation on the other. In the first case there is undue excita- tion, and if we select remedies to increase secretion or excretion, they will be of a sedative character. In the 108 STUDY OF DIAGNOSIS. other case there is a want of innervation, and the reme- dies will be those which will give stimulus and tone. There is a sodden, unpleasant looking tongue, which is quite as good evidence of cacoplastic material in the 'blood as any we can find. We recognize at once the evidence of enfeeblement of the digestive functions, and if there is local irritation we expect that the exu- date will be of this character, readily breaking down and destroying the tissues. EXAMINATION OF THE DISCHARGES. The examination of the discharges in common dis- eases is usually quite superficial, and whilst it has some diagnostic value is usually of little importance. The physician from force of habit asks after the discharge of urine and feces. Has the patient passed urine? freely? was it high colored, or what was its color? Has the patient's bowels been moved? how often? These are the common questions, and the answers are very uncertain and indefinite. Possibly the physician wishes to examine "the vessel," but in these days he is usually satisfied with these casual inquiries, and pre- fers to get his information from pleasanter sources. In the olden time examination of "the vessel" was of greater importance, for the principal part of the phy sician's business was to fill it-medicine meant dis charges. It may be well to give this subject' a brief study, though we do not attach such great importance to it. We may divide the study into five parts-a, with refer- ence to the discharge from nose and mouth; b, with STUDY OF DIAGNOSIS. 109 1 reference to the discharges from the skin; c, with refer- ence to the discharges from the urinary apparatus; d, with reference to the discharges from the bowels; and e, with reference to the discharges from the reprodue- tive organs. FROM THE NOSE.-The discharges from the nose are of local significance, and indicate changes of function and structure in these cavities. In measles and typhus, catarrhal symptoms are among the most prominent, and in the first are almost pathognomonic; but these and epidemic influenza are the only instances where the disease is referred to the blood. The thin, glairy secretion is evidence of irritation and determination of blood. The white of egg looking mucus of active inflammation. The yellowish, glairy discharge of commencing suppuration-muco-pus, and the opaque, yellowish, non-tenacious secretion, of the subsidence of inflammatory action. Dryness of the anterior nares is usually referred to scanty or arrested lachrymal secretion; too much mois- ture of the anterior nares, thin, watery, to increased lachrymal secretion. In chronic disease of the nasal cavities, the condition. of the parts is pretty clearly shown by the character of the discharges which have the entire range of mucus, muco-pus and pus. In determining the diagnostic value of these discharges, we will be guided by the same rules as in other situations. We wish to know the phy- sical properties of normal mucus, and of normal pus, and we will then have a standard of comparison; this we will study in discharges from the respiratory tract below. 110 STUDY OF DIAGNOSIS. FROM THE MOUTH.-The discharges from the mouth proper are of saliva with some mucus secretion. But through the mouth we have all the discharges from the respiratory tract below, of mucus, pus, blood, exudative material, etc. We also have occasionally discharges from the digestive tract, the stomach, upper small intes- tine, and secretion from the liver. The saliva normally is a thin, transparent. slightly viscid fluid, with a marked alkaline reaction to litmus paper. If it loses these properties in degree, or is in- creased, we will conclude that the first act of digestion. is improperly performed. Physicians have not been properly impressed with the importance of buccal diges- tion, and frequently direct their remedies to the stomach when it is not at fault. We have already seen that dryness of the mouth evi- denced arrest of secretion, and necessarily impairment of the digestive process. If the salivary secretion is found to be scanty, we anticipate a wrong of digestion, especially of starchy foods, and a wrong of nutrition. It is usually associated with excitation of the nerve centres, and local disease presents unusual irritation. We have the same results where the saliva is constantly thrown off in chewing and smoking. The remedies suggested in chronic disease by scanty secretion of saliva are, Iris Versicolor, Phytolacca, Panax, and some others of this class, with the Iodides and Bromides, especially of Ammonium. Increased secretion of saliva is found as a symptom in some forms of chronic disease, and occasionally in acute disease. If marked, it interferes with digestion, and is a cause of depravation of the blood. This may seem singular to the reader, and yet I think any one ! STUDY OF DIAGNOSIS. 111 1 } who has closely observed cases presenting this symptom will bear me out. The tendency is always to low grades of albuminoid deposits-cacoplastic, or aplastic. In acute disease the remedies will be the Alkaline Sulphites or Sulphurous Acid, or sometimes Chlorate of Potash, or Chloride of Sodium. Quinine and Nux Vomica are thought of for the wrong of innervation, and Hydrastis and Podophyllin for the wrongs of the intestinal canal. The same remedies will be applicable in chronic disease, and in addition we may think of Phosphorus, Sulphur, and sometimes Arsenic. It is hardly worth while to speak of changes in the character of saliva as regards its viscosity, as it is always associated with excess in quantity, and the indications for remedies will be as above. I would call attention, however, to the need of antiseptics in these cases, for very surely we will have sepsis as a prominent feature in the progress of acute disease. If the proper antiseptic is selected, as elsewhere described, whether Sulphite of Soda, Sulphurous Acid, Chlorate of Potash, Baptisia, or Muriatic Acid, this symptom will pass away. The reaction of the secretions of the mouth to test paper will be found to vary, and this will sometimes in- dicate the class of remedies to be selected. The alka- linity may be markedly increased, and acids will be as- sociated with remedies to influence the digestive pro- cess. In such a case, with dyspepsia, Muriatic or Lactic “Acid, largely diluted, with the addition of a small por- tion of Nux, will cure when the ordinary means have failed. In infantile dyspepsia, we sometimes find the saliva neutral, or in rare cases the entire secretions of the mouth are slightly acid. We find the same condi- tions in the adult, though not so often nor so marked. 112 STUDY OF DIAGNOSIS. 1 1 In such cases we would give Phosphate of Soda, and surely expect the patient to amend rapidly. FROM THE STOMACH.--Ejections from the stomach as the result of disease may sometimes give valuable in- formation, though usually we depend more upon what the patient tells us than upon what we see. But as a matter of interest we may examine the discharges. Eructations in dyspepsia are very acid or feebly acid. The first is very common and is usually met by an alkali or Bismuth, though experience shows that this is not good treatment, or at least but a part of good treat- ment. It is associated with hyperesthesia, demanding Aconite, Hydrocyanic Acid, Rhubarb, Ipecac, and like remedies; with externally the wet pack, either of water or water with an acid. The second evidences a condi- tion of atony, and suggests Muriatic and Lactic Acids, with Hydrastis and similar bitters, Podophyllin,,etc. Eructations containing a yellowish, or yellowish- brown coloring material, and of a bitter taste, shows irritation of the upper small intestine, and sometimes an irritation of the entire chylopoietic apparatus. The remedies will be such as prove sedative to these parts. Blood in the discharges has a variable significance. If in small quantities, during violent vomiting, we may conclude that some minute vessels have given away; if dark colored and clotted, we conclude there is passive. hemorrhage usually from congestion, except in the rare case of ulceration, with erosion of some of the vessels, when the discharge may either be of bright or clotted blood. Vomiting of considerable quantities of mucus is occa- sionally noticed in persistent atonic dyspepsia, and its STUDY OF DIAGNOSIS. 113 therapeutic value will be obvious. Vomiting of pus is at once referred to ulceration, the result of chronic in- flammation. The "black vomit" of yellow fever, and some rare cases of congestive, intermittent and remittent fevers, shows the breaking down of the blood, as well as the congestion of the digestive mucous surfaces. FROM THE RESPIRATORY TRACT.—The discharges from the respiratory tract are of mucus, pus, blood, and the material of exudation. As heretofore remarked, we wish to have a clear idea of the origin and value of these discharges, and senses trained to recognize them when seen. In health the respiratory mucous mem- brane is continuously lubricated with mucus, but it is not in quantity to be discharged by mouth; even the increase of quantity is evidence of disease. If mucus is thin, glairy, and very tenacious, we know that it comes from a mucous membrane in a condition of great vascular excitement-inflammation. The more marked these proporties, the more active the excite- ment. We see it in minor degree in catarrhal bron- chitis, but most marked in sthenic bronchitis when secretion is first established. The typical remedy is Veratrum. The opaque mucus, not so tenacious, is associated with a subsidence of the inflammation and resolution. The quantity may be such as to enfeeble the part or the patient, but other than this it is regarded as a favor- able symptom. The reader must not suppose from this that abundant opaque mucous discharges are essential to recovery, for they are not, and the patient convalesces. better if the discharge is never in excess, and but little 10 114 STUDY OF DIAGNOSIS. changed in character. The typical remedy is Ipecac. Change of color evidences local structural disease, and discase of the blood, whatever the color may be. Shades of yellow and green show suppuration-the dig charge is more or less purulent. Shades of brown, if not from blood in this discharge, show a low grade of inflammation and impairment of the blood. In some of these cases thé discharges look like "prune juice," or still worse, like the washings of spoiled beef. Globular sputa is characteristic of pneumonia, as the glairy, tenacious mucus is of bronchitis. So marked is this character of the expectoration in inflammation of the parenchyma of the lungs, that it is evidenced, not only in the single portions of mucus expectorated, but when the patient spits in a vessel, they all run together to form a globular mass. The cheesy expectoration, lacking consistence, seem- ing to be somewhat granular, is usually regarded as tuberculous. Whilst there are exceptions, it is prob- able that it may usually be regarded as evidencing aplastic or cacoplastic deposits, and a condition favoring tuberculosis, if it is not broken down tubercle. Masses of dessicated mucus are sometimes expec- torated, that are well calculated to deceive. They are in larger and smaller granules, and fully meet the popular idea of tubercular deposit. Yet when we take a portion and soften it with water on a glass, it gives the glairy, tenacious mucus, and not the friable, tuber- cular matter. These little bodies are evidently from accumulations in mucous follicles, principally in the larynx, which are forced out in the act of coughing. Pus from mucous membranes, will in appearance take the entire range of this product. It is usually admixed STUDY OF DIAGNOSIS. 115 1 with mucus, and thus has greater consistence. It is laudable, or bad, thin, thick, bland, ichorous, yellow, green, brown, etc. It evidences local destruction, though it may be but superficial, the relationship be- tween mucus and pus being very intimate. The grada- tions of pus have the same significance here as elsewhere. Blood may be discharged from the throat and pha- rynx, from the stomach, from the larynx, and from the lungs. From the throat and pharynx it is of usual color, is not frothy, and is ejected by an act of the will. Blood from the stomach is of darker color, is sometimes admixed with food and the secretions of the stomach, or is in part clotted. Blood from the larynx is but little frothy, is of usual color, and is in part discharged by an act of will. Blood from the lungs is usually bright, frothy, and wells up into the mouth without the con- sciousness of the patient. We always want to know whether hemorrhage is active or passive, as the treatment will depend upon this. Very fresh and bright blood would evidence active hemorrhage, whilst deeper colored blood would evidence passive hemorrhage. Yet we will find better evidence in the color and expression of the face and in the pulse. Active hemorrhage calls for Veratrum and Ipecac, whilst passive hemorrhage refers us to Erigeron, Gallic Acid and Ergot. Mucus streaked with bright blood evidences inflam- mation, and is seen in sthenic bronchitis. If the blood is less bright it evidences a lower degree of inflamma- tion, or rather impairment of the life of the part, and if it assumes the "prune juice" character, it evidences an unpleasant condition. The blood in the sputa of pneumonia is rusty, and may be found perfectly admixed 116 STUDY OF DIAGNOSIS. with the mass of mucus, or forming a central nucleus. If here it becomes brown, or has the "prune juice character, it evidences a low grade of inflammatory action and impairment of the life. We occasionally see exudative material. First, as fibrinous exudations from the mucous surfaces, in croup and in croupous bronchitis; second, as broken down tubercular material from the parenchyma of the lungs. The last is sometimes very characteristic, but at others it is so masked by the bronchial secretions and by the breaking down of the structures, that we can hardly recognize it. Call it cheesy, friable, and the fluid dif fering in character from laudable pus in consistence, color, etc., and the reader will get a fair idea of it. EXAMINATION OF THE URINE. The physician in common practice has but little knowledge of the urine-possibly he may not know the physical properties of normal urine. As we have stated so often, this is the first thing that needs be learned. If we can recognize normal urine when we see it, it will be possible to tell its common variations by sight. Yet here we find a serious obstacle in the way-the very great variations of normal urine both in color and in quantity. Yet there is a normal color, and these differences are more in its concentration than in any real change. The quantity may vary very greatly without any marked change in the excretion-water forming its bulk.* *COMPOSITION OF RENAL EXCRETION.-The renal excretion has naturally an acid reaction, and consists chiefly of urea, with some uric acid, sundry other animal products of less importance, in- 麵 ​STUDY OF DIAGNOSIS. 117 The majority of physicians attach but little value to the ordinary examination of urine by the sight, which is popularly known as " Uroscopy." Yet whilst we are convinced that there is a broad basis of charlatanry, there is evidently something real that serves as a basis for selecting remedies. Evidently it is worth study, and I think I can point out a method by which the reader can learn all there is to be known. It is claimed that all disease is represented in change of the urinary secretions, and that these changes can be recognized. Let us admit it, and then to study diagnosis by the urine we will take cases of disease cluding certain coloring-matters, and saline and gaseous sub- stances, all held in solution by a large quantity of water. The quantity and composition of the urine vary greatly ac- cording to the time of day; the temperature and moisture of the air; the fasting or replete condition of the alimentary canal; and the nature of the food. Urea and uric acid are both composed of the elements carbon, hydrogen, oxygen, and nitrogen; but the urea is by far the more soluble in water, and greatly exceeds the uric acid in quantity. An average healthy man excretes by the kidneys about fifty ounces, or twenty-four thousand grains of water a day. In this are dissolved five hundred grains of urea, but not more than ten to twelve grains of uric acid. The amount of other animal matters, and of saline substances, varies from one-third as much to nearly the same amount as the urea. The saline matters consist chiefly of common salt, phos- phates and sulphates of potash, soda, lime and magnesia. The gases are the same as those in the blood-namely, carbonic acid, oxygen,, and nitrogen. But the quantity is, proportionally, less than one-third as great; and the carbonic acid is in very large, while the oxygen is in very small, amount. The average specific gravity does not differ very widely from that of blood-serum, being 1.020.-Huxley. 118 STUDY OF DIAGNOSIS. where the diagnosis is well made, and compare the urine with the normal standard of health. Certainly we will now be able to see these differences if they exist. Here is the patient suffering with pneumonia, bronchitis, or tuberculosis. Is there a urine that represents pncu- monia, bronchitis, or tuberculosis? Here are patients. suffering from well recognized nervous lesions, neural- gia, paralysis, epilepsy, etc. Is there a urine that rep- resents neuralgia, paralysis, epilepsy, etc.? Here are certain well defined lesions of digestion, blood-making, nutrition, and retrograde metamorphosis. Are there urines that represent these lesions of digestion, blood- making, nutrition, and retrograde metamorphosis? But supposing we do not find that these diseases are represented in the urines, and we can not diagnose the situation of local disease from it, possibly we can diag nose a general condition of disease. At least we will very certainly learn what is to be learned, and we will learn something that is valuable. The ordinary examination is conducted with refer- ence to-a, quantity; b, specific gravity; c, color; d, deposits; and e, change in its constituents. In every day practice the examination is of necessity superficial, and it is only when symptoms point to lesions of the urinary apparatus, or the disease is so obscure that we resort to every known means, that a critical examina- tion of urine is made. To determine anything definitely with regard to this secretion, the urine must be passed in a separate vessel, (which should be clean), and the urine of twenty-four hours saved for inspection. All tests of color should be made in clear white glass containers by means of transmitted light, and all deposits should be examined in a similar manner. STUDY OF DIAGNOSIS. 119 QUANTITY.—The normal quantity of urine in the healthy man is about fifty ounces in the twenty-four hours, and this is of a specific gravity of 1.020, contain- ing 1080 grains of solid matter. The urine may mea- sure but thirty ounces, yet the specific gravity being high, 1.030, the secretion will be sufficient for blood depuration. Again, the urine may be passed in normal quantity, or as much as sixty or seventy ounces daily, and yet being of low specific gravity, 1.010, the patient will suffer from uræmia There is thus such indefinite- ness, that even though we know the quantity of urine in twenty-four hours, we can not tell whether depura- tion is sufficient or not. It may be remarked further that we do not expect as large secretion from the kidneys in disease, when the body is inactive, as in health when it is active. Scanty urine is characteristic of all forms of disease, and even accurate measurement of quantity and specific gravity will not tell us so well whether it is sufficient, as other symptoms that might seem to the casual ob- server to be more indefinite. an SPECIFIC GRAVITY. The specific gravity is deter- mined by a urinometer, and having the quantity passed in twenty-four hours, we will, with this instrument, be able to determine the amount of solids in this period. But it does not determine what solids. If the urine be of low specific gravity, and in small quantity, the blood may be so freed from urea, that the function may be regarded as normal, for there may be but little of the "500 grains of other animal matter and saline sub- stances" passing out, and the urea for excretion may not be more than two or three hundred grains. Con- 120 STUDY OF DIAGNOSIS. versely, if the urine be of high specific gravity, and passed in considerable quantities, the patient may still suffer from uræmic poisoning, for the adventitious solids, sugar, albumen, saline matters, etc., take the place of urea. It is well to get an idea of the uncertainty of this examination, otherwise we might be led into error. We reach no conclusions from these examinations that are not proven by other symptoms; and usually we make these examinations to confirm conclusions reached by more definite expressions of discase. If the patient is suffering from the nervous excitation or coma of re- tained urinary excretion, the examination determining scanty urine becomes of value. If the patient shows evidence of waste, and we find too free excretion, we conclude that this drain upon the blood should be stopped. In any wrong of innervation, we think of the urinary excretion as a possible source of disease, and if we do not find the cause elsewhere, we give the urine a critical examination. In any disease of debility, especially when chronic, if we can not find the cause elsewhere, we turn at once to the kidneys as a possible seat of the trouble, and make the necessary examination. COLOR.* The color of the urine has been regarded as the best diagnostic evidence in the common` exami- *Urohæmatin, the substance which gives to healthy urine its peculiar tint, is of more importance to the Clinical Physician than the majority of urinary ingredients: for the quantity passed in the twenty-four hours is not only an index to the tear and wear of the tissues, but the best measure we at present possess of the rapidity with which man burns life's lamp. The amount STUDY OF DIAGNOSIS. 121 nation of this fluid. Of necessity, if any definite in- formation is to be had, the urine must be passed apart from the fæces, and as before named, it should be exam- ined in white glass by transmitted light. The physician in ordinary, recognizes the normal color varying from a pale straw to a yellowish brown tint, and he classes the urine of disease as dark and light or pale. Scanty and high colored urine is asso- ciated with acute febrile and inflammatory diseases, and pale urine with diseases of relaxation. Possibly this is quite as definite as the ordinary professional thought, and we may well ask ourselves if there is any reason for this indefiniteness. Most assuredly there is; and we find it in the wide range of coloration in health, and also in diseases in which color has but little meaning.† of all the ingredients of the urine we have hitherto considered, are much more under the influence of the diet than that of uro- hæmatin, the quantity of which may be said to be a tolerably exact measure of the destruction of blood corpuscles.-Harley. †The color of the urine varies greatly in disease. It may be perfectly white, yellow, brown, red, black, green, or blue, and each of these tints, in the absence of ingesta capable of acci- dentally producing them, invariably indicates the existence of grave disease. Normally colored urine does not, however, exclude the possi- bility of disease, for the color of the freshly passed urine is no absolute criterion either of the quantity or the kind of coloring matter it contains. The abnormal like the normal pigments are often combined with some of the other urinary ingredients in the form of colorless compounds, and it is not until the compound is decomposed, and the pigment set free, that we can take cogni- zance either of its quantity or its quality. For example, here are three urines: 1st. A pale, almost colorless urine from a healthy 11 122 STUDY OF DIAGNOSIS. Let us take the opinion of Dr. George Harley, (and I give it in extenso in the foot note,) a most excellent observer, that the coloring matter of the urine-uro- infant, aged 18 months. It has a specific gravity of 1 018. 2d. An equally pale, almost colorless urine from a girl, aged 19, suf- fering from chlorosis. It has also a specific gravity of 1.018. 3d. A dark straw-colored, but perfectly transparent urine from a healthy man, aged 33. It has likewise a specific gravity of 1.018. In fact, these three urines have been purposely selected on account of their having the same specific gravity. To each of these add a quarter of their bulk of strong nitric acid, and bring them to the boiling-point. Watch the change. The infant's pale urine is scarcely altered; the man's dark urine is only slightly deepened in tint; whereas the almost colorless urine of the chlorotic girl has assumed an intensely red hue. What is the cause of this difference? The infant is in the bloom of health- there is no waste of blood-corpuscles in it-all the blood discs it possesses are employed in the development of its frame. The man has arrived at maturity; he is still in the prime of life, and in the enjoyment of perfect health; his blood-corpuscles are not wasted, but merely consumed in the tear and wear of every-day life. The young woman, on the other hand, is suffering from chlorosis; she has a pale lip, and a blanched cheek; her co¹ pus- cles are being too rapidly consumed; her life's blood is oozing. away by the kidneys, and there it appears as an excess of urohæ- matin in her urine. Take again these two urines so different in appearance. They are from young men about the same age (24 years). The one urine is perfectly colorless, like water; the other is of a deep red color-case of hematuria from disease of the kidney. On adding strong hydrochloric acid to the colorless urine it rapidly assumies a port wine tint, whereas the same amount of acid added to the red urine, instead of heightening, actually destroys the color it already possesses. And why? Simply because the pale urine contains an excess of combined urohæmatin, which is liberated by the acid; whereas, the red urine contains merely a number of free blood-corpuscles, which become coagulated, and, as the STUDY OF DIAGNOSIS. 123 hæmatin-represents the wear and and especially of the red corpuscles. this to show us definitely the extent tear of the tissues, We might expect of this wear and coloring matter in them is insignificant in quantity when com- pared with the amount of urohæmatin in the other, no sooner are their cell-walls destroyed and the contained hæmato-globulin set free and coagulated, than the red color disappears. Now which of these two classes of urine denotes the most danger: Most assuredly not that containing the free blood-cells. A very small quantity of blood will sometimes color a great deal of urine; whereas an immense destruction of blood-corpuscles may take place in the body, and their debris be so eliminated as to be invisible to the eye until the application of an acid sets it free In fact, experience has shown me that the normally colored urine of disease is a most treacherous guide to go by. It often lulis the inexperienced into the belief that there is nothing materially wrong, when a. grave lesion is making rapid strides toward a fatal termination. Not very long ago I was told by an intelli- gent practitioner that a young lady, regarding whose health we were consulting, was laboring under hysteria "The secretions," as he termed them, being "all right," my opinion had been asked more with the view of satisfying the friends who were get- ting fidgety than anything else. The case appeared to be what he said, until he added, "She is well fed, and yet she loses flesh, and I don't know why." This remark at once brought us back to the urine, which he assured me was perfectly natural in color, and contained neither sugar nor albumen. I analyzed some, and the case proved the very counterpart of the lad's just spoken of. Although the girl's urine was natural in color, her life's blood was imperceptibly oozing away with it. This is no solitary ex- ample: I might cite many cases of so-called hysteria, which were in reality cases of serious, though obscure disease; but that is surely unnecessary. Who amongst us has not seen patients die, and their disease put down as, only hysteria? The time is, nev- ertheless, not far distant when we shall learn that hysteria is something more than "mere functional derangement." Hysteria may be a convenient term, but, after all, it is only a cloak of 124 STUDY OF DIAGNOSIS. 1 the tear. But it does not; for as the cases given show, color is not in proportion to the amount of urohæmatin, but in proportion to that uncombined, and to its degree of oxidation. ample dimensions which hides the rags of ignorance. It is a name instead of an explanation, a sham instead of a reality. And what is still worse, it tends to keep us in ignorance by sti- fling legitimate inquiry; for no sooner do the majority of practi- tioners find a name for the disease than they cease to fathom its cause. In some cases of cerebral and spinal disease the excess of urohæmatin in the urine is so great that after it has been set free by an acid and taken up with ether, the ether, after stand- ing, solidifies into a red currant jelly-like mass, and may actually, in some cases, be cut with a knife. The best way of showing this is to boil four ounces of urine; then add nitric acid to set the coloring matter free. When cool, put the urine into a six-ounce bottle along with an ounce of ether. Cork the bottle, thoroughly shake it, and afterwards place it aside for twenty-four hours. At the end of that time the ether will sometimes be found to be like a red tremulous jelly. Such a case is, of course, a very bad one; but these are not nearly so uncommon as one would imagine. In some of the worst cases of urohæmaturia the urine is neutral or even alkaline, and the fons et origo mali is to be looked for in the brain or spinal cord. In- deed, we may often be led to a correct diagnosis of obscure cere- bral and spinal disease, by finding urohæmaturia associated with a saccharine or a phosphatic condition of the urine. In a case of chronic cerebral disease, which I saw with Mr. T. Carr Jackson, the quantity of urohematin regularly varied pari passu with the severity of the paroxysms, nitric acid turning the urine red, purple, or even bluish (blue matter being after a time deposited on the bottom and sides of the test-tube), according to the severity and duration of the attack. It ought never to be forgotten that alkaline remedies, as well as certain vegetable foods, may increase the urohæmatin. Even the external use of carbolic acid sometimes turns it black. ¿ When urohematin exists in a free state, the urine is red in STUDY OF DIAGNOSIS. 125 Notwithstanding this we always associate the high colors or the wrong colors with severe disease. As Dr. Harley remarks, "it may be perfectly white, yellow, brown, red, black, green or blue, and each of these color before any acid is added. These cases differ from hæmatu- ria, in the urine being clear and transparent, and devoid of blood-corpuscles, and from intermittent hæmaturia in the absence of congestive casts. If it contains a deposit, the deposit may or may not be high-colored; but in any case the supernatant liquid is clear as well as red. Another fact, which is of great clinical importance is, that the urohæmatin is not always in the same state of oxidation; and, like indigo, its color depends on the amount of oxygen it contains. It may be yellow, red, or brown. In consequence of this, different acids act upon the urine differ- ently. In one case nitric, sulphuric, or hydrochloric acid may produce the same results; in another hydrochloric acid turns the urine red, while nitric acid makes it blue, green, or yellow. In a third sulphuric acid may develop the color better than the others. To illustrate these remarks: Take the case of a gentleman 33 years of age, whose urine to the eye appeared perfectly normal in color. On adding strong nitric acid, however, to this urine it immediately became of a blood-red hue, whereas hydrochloric acid had no effect upon it until some minutes had elapsed, when it gradually caused it to assume the same tint as that produced by the nitric acid. When sulphuric acid is slowly added so as to fall to the bottom of the test-tube, a reddish-brown line appears at the point of contact, and this gradually deepens until, in the course of six hours or so, it assumes a more intense color than that produced by either of the other acids. This is an important case in another point of view, namely, as proving the value of urinary analysis in cases of obscure disease. The only symptoms that this patient labors under are those of an irregular kind of dyspepsia, with an occasional pain in the epi- gastrium. He is in easy circumstances, takes plenty of nourishing food, wants for nothing, yet he gradually gets weaker and weaker, and has lost 17 lbs. in the course of the last year. Even 126 STUDY OF DIAGNOSIS. tints, in the absence of ingesta capable of accidentally producing them, invariably indicates the existence of grave disease But though we concede the general indication, is there any one who can tell the diagnostic "} the locality in which the patient lives is a remarkably healthy one (he was sent to me from Anglesey by Dr. D. Williams, of the Menai Bridge), and if it had not been for the condition of the urine, his symptoms would have remained a mystery. This, too, was one of those cases in which the amount of urohæmatin was so great that it caused the ethereal solution to solidify into a jelly. An excessive excretion of urohæmatin is not limited to cases such as we have been describing. It occurs to some extent in several diseases, especially those in which there is an excessive tissue metamorphosis, and consequent too rapid blood consump- tion. Hence we occasionally meet with it in low fevers, in diph- theria, in pneumonia and some other inflammatory affections, in lesions of the nervous system, during an attack of gout, after the fit of ague, and during convalescence from nearly all grave diseases. It is, however, in chlorosis (either in the male or female), and the many unnamable obscure affections of that class, where it becomes a dangerous symptom. In fact, it always indicates the existence of a past or present mischief meriting the closest attention of the physician, and where we can not remove the cause we must at least attempt to check the effects of the symptom, namely, to restore to the blood as much as possible of the material which is being drained from it. Every one knows the effects of iron upon the system, but iron alone is not always sufficient for our purpose. Something more is wanted, and that is best supplied by the preparations called the syrups of phos phate of iron. Many syrups have been sold under this title. There are the American syrups; the compound syrup of the phosphate of iron, or "chemical food," as it is sometimes named; the syrup of the superphosphate of iron and lime (excellent for children); and a few others. One and all of them are good in particular cases, but they must always be associated with a : STUDY OF DIAGNOSIS. 127 value of each or either of these colors, and make it point us to the remedy? This, as the reader will see, is the practical question, and I confess that I can not do it. In exhaustive disease, in which we may suspect the judicious selection of regimen in order that the full benefit may be derived from them. The preparations of zinc, in grain or grain and a half doses, are also occasionally useful astringent tonics when the drain is very great. In some cases of disease the excretion of urohæmatin by the kidneys appears to be diminished, but this is only when the sys- tem has been so drained that there is little more to come away. In the last stage of chlorosis a great diminution in the amount of the urohæmatin in the urine takes place; so also in chronic cases of hæmaturia, notwithstanding that the urine perhaps looks red. Likewise in cases of chylous urine, in the albuminu- ria of pregnancy, and in chronic Bright's disease. In all these cases the blood has already been well drained of its constituents before a marked diminution in the amount of the eliminated urohæmatin-takes place. Blue and Green Urine.-A great sensation was created some years ago among Clinical Physicians and Pathologists when the first cases of blue and green urine were reported; all doubted, and many disbelieved in their existence. The least uncharitable thought that the patient had hoaxed the doctor. Knowledge has, however, advanced since then. Not one, but many observers have met with the same conditions; and now the doubters and disbelievers in the existence of either blue or green urine are only to be found among the ignorant. To Dr. Hassall we owe the first good report on the existence of blue urine. It was entitled-"On the Frequent Occurrence of Indigo in Human Urine, and on its Chemical, Physiological and Pathological Relations." I must here guard you against falling into the common error of supposing that the urine is blue or green at the moment of being voided, for, as far as I am aware, such a condition has · 128 STUDY OF DIAGNOSIS. 1 removal of the blood corpuscles by way of the kidneys, the addition of Nitric, Muriatic or Sulphuric Acid to the urine may give us the evidence of this masked hemorrhage through these organs. The directions given in the foot note may be followed. never yet been observed. In the cases. hitherto reported it has only been after exposure to the air, or after the application of chemical agents, that the urine has been observed to become of the colors alluded to. In Hassall's best-marked case, for exam- ple, the urine was of a light brown color when voided, somewhat alkaline, and had a specific gravity of 1.017. In the course of three or four days it became thick and turbid, deep brown, greenish, bluish-green, yellowish-green, and finally nearly black; the scum on the surface remaining of a permanent, deep indigo- blue color. All these changes followed upon simple exposure to the air; but, as just said, chemical agents may produce one or more of these changes. Thus, for example, in Munk's case of green urine, when passed the urine was of a dark red color, but on the addition of ammonia it became green. Like everything else when properly understood, these changes have nothing mys- terious about them. The body has not created anything new in making blue or green urine. Indeed, as in disease no new func- tions are ever created, but only a change occurs in the rhythm and force of those already existing, so in disease no new sub- stances are ever created, but only a change takes place in the quantity or in the quality of those normally existing. It is now twelve years since I adopted these views, and the longer and deeper I peer into the wondrous workings of the human frame, the more am I satisfied with them, and the easier do I find the comprehension of disease. Physiology and Pathology are but one study; and although a man may be a Physiologist without being a Physician, no man can be a Physician without being a Physiologist. The same laws that regulate health regulate dis ease. The very effects we are now studying are a striking illus- tration of the justice of these observations. 7 STUDY OF DIAGNOSIS. 129 DEPOSITS.*—A deposit from the urine is " always a sign of something wrong," but, unfortunately, it does. not always determine for us the character of the wrong, or the remedy. To obtain a deposit, the urine is passed in a separate vessel, which being covered, is allowed to *A deposit in the urine is always a sign of something being wrong, and although, as we have seen, it may occur from very trivial causes, whenever it takes place without appreciable cause, in the otherwise apparently healthy, it is a sign not to be disre- garded, as, under such circumstances, it is not unfrequently either the forerunner or associate of gravel or stone. Uric acid in some form or other is the commonest ingredient of all calculi, and there is no period of life exempt from them. Urates are a very common deposit in the course of acute dis- ease, and they even seldom fail to recur at some period or other in the course of chronic affections. It is, however, only in dis- eases of an acute febrile or inflammatory type that their sudden appearance can be regarded as indicative of & crisis. Their sud- den appearance is due to an important change having occurred in the condition of the patient, and in general, though not always, it is a change for the better. Such, for example, is ob- served to occur in cases of gout and rheumatism where the climax has been reached. So also in pneumonia and pleurisy when re- solution and absorption commence. Should a patient, not laboring under any febrile or inflamma- tory affection, be every now and then troubled with a pink de- posit in the urine without any assignable cause, it will be found, in almost nine cases out of ten, that he is suffering from some chronic affection of the heart, liver, or spleen, with which is asso- ciated a tendency to gravel. In all such cases, therefore, steps should immediately be taken to counteract this disposition by the administration of alkaline tonics. Should there, however, be any counter-indication to the direct alkaline treatment, those acid salts are to be employed which, during their passage through the body, are converted into alkaline carbonates-such, for example, as citrates, tartrates, lactates, and acetates. Every now and then ૬ 130 STUDY OF DIAGNOSIS. \ stand from one to twelve hours. It is not well to ex- amine deposits from old urine, urine admixed with fæces, or urine in a chamber utensil that is continuously foul for want of proper washing. Urine undergoes de- composition, and this will give rise to some deposits; fæcal matter will obscure the subject, and a utensil that is allowed to contain decomposing matter will set up processes of change in urine recently passed. With regard to the value of deposits I can not do better than quote from Golding Bird, as his methods are the clearest I have seen: "ON THE CLINICAL EXAMINATION OF THE URINE.— The following observations may be of service to the practitioner, as a guide to his proceedings in the super- ficial examination of the urine, the most important part of which can be readily performed in a few moments in the sick room. Premising that the urine presented for inspection is either an average specimen of that passed in the preceding twenty-four hours, or at least that resulting from the first act of emission after a night's rest, unless the urine secreted at other times of the day be specially required. "Urine without any visible deposit, or decanted from the sediment.-A piece of litmus paper should be immersed in the urine, which, if acid, will change the blue color of the paper to red. Should no change occur, a piece of reddened litmus paper must be dipped in, and if thơ secretion be alkaline, its blue color will be restored; but if its tint remains unaltered, the urine is neutral. an exceptional case may arise, where a mineral acid tonic is de- manded; under such circumstances the above rule may be de- parted from, and the case treated according to its special require- ments.-Harley. STUDY OF DIAGNOSIS. 131 “Some of the urine should then be heated in a pol- ished metallic spoon over a candle, or, what is prefer- able, in a test-tube over a spirit lamp, and if a white deposit occurs, albumen or an excess of the earthy phosphates is present; the former, if a drop of nitric acid does not redissolve the deposit, the latter, if it does. If the urine be very highly colored, and not ren- dered opaque by boiling, the coloring matters of bile, or purpurine, are present. To determine which, pour a thin layer of urine on the back of a white plate, and allow a few drops of nitric acid to fall in the centre: an immediate and rapidly ending play of colors, from bluish-green to red, will be observed if bile, but no such change will be observed if purpurine alone exists. Should the highly colored urine alter in color or trans- parency by heat, the presence of blood must be sus- pected. "If the addition of nitric acid to deep red urine, un- affected by heat, produces a brown deposit, an excess of uric acid exists. If a specimen of urine be pale, immerse the gravimeter, and if the specific gravity be below 1.012, there is considerable excess of water, but if above 1.025, the presence of sugar, or a superabun- dance of urea is indicated. To determine the existence of either of these conditions, place a few drops of the urine in a watch-glass, add an equal quantity of nitric acid, and allow the glass to float on some cold water; crystals of nitrate of urea will appear in two or three minutes, if the latter exists in excess. Should this change not occur, the urine must be examined specially for sugar, which, it must be remembered, may exist in small quantities, without raising the specific gravity of 132 STUDY OF DIAGNOSIS. 1 the fluid. For this purpose boil a small portion with an equal bulk of liquor potassæ in a test-tube, and the development of a brown color will at once afford evi- dence of the almost certain existence of sugar. An excess of coloring matter, rich in carbon, should always be sought after, on account of its pathological import- This is readily done by boiling some urine in a tube, and, whilst hot, adding a few drops of hydro- chloric acid. If an average proportion of the pigment exist, a faint red or lilac color will be produced; but if an excess is present, it will be indicated by the dark red, or even purple tint assumed by the mixture. ance. "Should the urine be alkaline, add a drop of nitric acid; if a white deposit occurs, albumen is present; if brisk effervescence follows the addition of the acid, the urea has been converted into carbonate of ammonia. “Examination of the Sediment Deposited.—If the de- posit is flocculent, easily diffused on agitation, and scanty, not disappearing on the addition of nitric acid, it is chiefly made up of healthy mucus, epithelial de- bris, or occasionally, in women, of secretions from the vagina, leucorrhoeal discharge, etc. "If the deposit be ropy and apparently viscid, add a drop of nitric acid; if it wholly or partly dissolves, it is composed of phosphates, if but slightly affected, of mucus. If the deposit falls like a creamy layer to the bottom of the vessel, the supernatant urino being co- agulable by heat, it consists of pus. "Urine sometimes appears opaque, from the presence of a light flocculent matter diffused through it, neither presenting the tenacity of mucus, nor the dense opacity of pus. Although scarcely sufficient in quantity to in- terfere with the perfect fluidity of the urine, if a little STUDY OF DIAGNOSIS. 133 be placed in a test-tube and agitated with an equal bulk of liquor potassæ, the mixture will often become a stiff, transparent jelly. This peculiar appearance is demon- strative of the presence of the exudation, or large or- ganic globules formed under the influence of irritation, providing the urine does not coagulate by heat, for should it do so, the existence of minute quantities of pus may be suspected. "If the deposit be white, it may consist of urate of ammonia, phosphates, or cystine; the first disappears on heating the urine, the second on the addition of a drop of diluted nitric acid, whilst the third dissolves in am- monia, and the urine generally evolves an aromatic odor like the sweetbrier, less frequently being fetid. "If the deposit be colored, it may consist of red par- ticles of blood, uric acid, or urate of ammonia, stained with purpurine. If the first, the urine becomes opaque by heat; if the second, the deposit is in visible crystals; if the third, the deposit is amorphous, and dissolves on heating the fluid. “Oxalate, and more rarely oxalurate (?) of lime are often present diffused through urine, without forming a visible deposit: if this be suspected, a drop of the urine examined microscopically will detect the characteristic crystals. "If the urine be opaque like milk, allowing by re- pose a cream-like layer to form on the surface, an emul- sion of fat with albumen is probably present. Agitate some of the urine with half its bulk of ether in a test- tube, and after resting a few minutes, a yellow ethereal solution of fat will float on the surface of the urine-a tremulous coagulum of albumen generally forming be neath it. 134 STUDY OF DIAGNOSIS. ! "Much of the little time required for the investiga- tion thus sketched out, may be saved by remembering the following facts: "If the deposit be white, and the urine acid, it in the great majority of cases consists of urate cf ammonia; but should it not disappear by heat, it is phosphatic. "If a deposit be of any color inclining to yellow, drab, pink, or red, it is almost sure to be urate of am- monia, unless visibly crystalline, in which case it con- sists of uric acid. "The following tables briefly point out the readiest mode for the examination of crystalline deposits, both by chemical tests and by microscopic examination. The latter mode is of course preferable to all others, both for the accuracy and extent of the information it affords, as well as for economy of time: TABLE FOR DISCOVERING THE NATURE of urinarY DEPOSITS BY CHEMICAL RE- 1. {Deposit white......... colored, AGENTS. 25 2 2.{ 8. { ཝ.{ 1. { 2 { dissolves by heat, Urate of ammonia. 3 Cystine. 4 ... insoluble by heat,. soluble in liquor ammonia,... insoluble in, 6. :: soluble in acetic acid,... Earthy phosphates. insoluble in visibly crystalline, Oxalate and oxalurate of lime. Uric acid. pale, readily soluble by heat, 66 amorphous,...……………. deeply colored, slowly soluble by heat..... 6 Urates. Urates, stained by purparine. TABLE FOR THE MICROSCOPIC EXAMINATION OF UBINARY DEPOSITS. Deposit amorphous, visibly crystalline,. ..... vanishes on the addition of liquor potassæ, permanent after the addition of liquor potassæ. Orystals in well defined octahedra,...... not octahedral,. 2 3 Urate of ammonia. Phosphate of lime. Oxalate of iime. 4 STUDY OF DIAGNOSIS. 135 { Crystals in six-sided tables, soluble in 66 5. { 6. { • 8. 9. { :{ CL not tabular, nor soluble in ammonia,.. 5 soluble in acetic acid,............ 6 insoluble in acetic acid,………………….. 8 in prisms or simple pennæ,. radiated or foliaceous.......... soluble in acetic acid with ef- fervescence,……………. ………………. soluble in acetic acid without effervescence......... in dumb-bells or radiated,..... spherical or colored,………….. in lozenges or compound crystals, in spherical crystals 7 Cystine. Neutral triple phosphate. Carbonate of lime. Bibasic-triple phosphate. Oxalurate (?) of lime. Uric acid. Urate of soda or ammonia. EXAMINATION OF THE FÆCES. THE BOWELS.--Excretion by the bowels does not hold that importance now that it did in olden times. We learn by experiment that of the four to six ounces of fæces, giving one to one and a half ounces of solid residue, but about 100 grains are of excrementitious matter.* The liver, which was formerly thought to play so im- portant a part in removing waste of tissue, and excre- mentitious matter, yields but a few grains of this (four to eleven grains). It has also been conclusively deter- mined that there are no agents that act upon the liver, increasing its secretion (cholagogues); that mercury in any of its forms does not influence it in the least, ex- cept when it produces its constitutional effect, and when given to catharsis, it lessens the secretion. All cathar- tics in cathartic doses diminish the secretion. Even our Podophyllin, which has been regarded as a Samson *See Principles of Medicine, p. 126. 136 STUDY OF DIAGNOSIS. in its influence upon the liver, diminishes the secretion in cathartic doses, and in minute doses lessens the bile solids while it slightly increases the quantity excreted. 7 If we can learn that the liver performs an important function in digestion and in blood-making, furnishing its secretion for these purposes, and that it is admirably adapted to these purposes, and rarely the subject of disease, and that we have no medicines that influence it directly, to increase secretion, we will have made ar important advance in pathology, and will have much improved our therapeutics. We may classify it with the pancreas, and may expect to influence it only by those remedies that control the circulation, act through the sympathetic nervous system, and influence the pro- cesses of blood-making. Our inquiry in regard to the fæces will have refer ence, first, to the increase or diminution of the secre- tion; second, to the condition of the intestinal canal, as an apparatus for digestion; and third, to any abnor- mal constituent, or marked change in the character of the excretion. Increase of the fæces, in proportion to its extent and duration, causes debility; for histogenetic material, either as food or tissue, is proportionably removed. Fluid fæces, whilst very frequently in excess as above, deserve attention more particularly as evidencing such lesion of the intestinal canal, as interferes with diges- tion and blood-making; and also with that due degree of distension of the blood vessels, which is necessary to proper circulation. Deficiency of fæces may depend upon the quality of the food, or upon its quantity; the largest proportion of fæcal material being furnished by the debris of STUDY OF DIAGNOSIS. 137 food; or it may depend upon an arrest of secretion, in which case we will have the same constitutional evi- dence that we would have in similar arrest from the skin and kidneys; or it may be dependent upon atony of the intestinal canal, which allows the material to ac- cumulate, without the natural effort at removal. Simple constipation gives rise to derangements of digestion, and the retention of effete material in the bowels occasions a feeling of malaise and dullness, with headache and fever, in so far as they are retained in the blood, or re-absorbed. The color of the discharges is sometimes of import- ance in determining the character of disease. The natural color, like the natural fetor, evidencing a con- dition of the intestinal canal in which its functions may be properly performed. The dark-brown or almost black color of the fæces, observed in typhoid disease, arises from the excretion of the coloring material of the blood; the red globules being broken down rapidly. The use of iron in any of its forms, and occasionally of sulphur or its salts, will darken the color of the fæces. The dark-green color of the faces that followed the ad- ministration of mercury, and was thought to be bile, was due to the formation of sulphuret of mercury. Greenish discharges are generally dependent upon an increase of acid in the intestinal canal, with irritation and consequent indigestion. It may, in part, be de- pendent upon the coloring matter of bile, which is thrown off by the fæces, in consequence of such irrita- tion. Clay-colored discharges refer to a general want of secretion; not only of the solitary glands of the intes- 138 STUDY OF DIAGNOSIS. tine, but of the associate viscera. It is an atonic con- dition, with impaired innervation and circulation. The natural odor of fæces seems to be dependent upon a special secretion in the neighborhood of the cæcum. It may be regarded as an evidence of normal activity throughout the entire intestinal track. Diminution of the odor is an indication of want of functional activity, as an increase will indicate in- creased activity. Fetor refers to decomposition of the intestinal secre- tions. It varies greatly from local causes, and can not be relied upon as indicating any special condition of the general system. The cadaverous fetor may, however, be taken as evi- dencing a septic condition, not only of the intestinal secretions, but also of the fluids and solids. It is difficult to determine change in the elements of fæces, and it will hardly form a part of ordinary ex- aminations. The principal of these I append, Lehman's Chemical Physiology being the authority. "The excrements in consumption are sometimes found to contain more fat than usual. Sugar is occa- sionally found in the fæces of diabetic patients. The stools are found to be black, chocolate-colored, or tar- like, when blood is contained in them, and this arises from the upper intestinal canal; so also the semi-liquid, green excrements which are observed occasionally in typhus and other diseases, depend upon blood, which is easily recognized by the microscope. Soluble albumen is found in the stools in dysentery, typhus, and occa- sionally in Bright's disease, and in cholera. The great- est quantity of epithelial cells are found in the dejec- tions of cholera. Cytoid corpuscles are very numerous # STUDY OF DIAGNOSIS. 139 in the excrements in catarrhal diarrhoeas, in dysentery, and occasionally in typhus and cholera. Hyaline mucus is observed in the excrements in catarrh of the large intestine; it arises from the follicles of the colon, and contains round or oval pale or granular cells and cell nuclei. Fibrinous exudations occur in the fæces in folli cular ulceration and in dysentery." DIAGNOSIS BY THE TOUCH. In our study of the senses, we found that the tactile sense could be wonderfully developed. Marked exam- ples of this may be found in the mechanic arts, not only of extreme delicacy, but of complex and difficult work accomplished through this sense alone. The education of this sense in the blind is another marked example, and it is well that a physician should make himself acquainted with the education of the blind, to see the range of this sense which in the majority has such imperfect development. What information can we gain by the sense of touch? Not much, one would say at first thought; yet we find it an important means of diagnosis if we study it care- fully, and train the sense of touch. The obstetrician relies wholly upon it, not only determining the presen- tation and position of the child, but the condition of every part engaged in the process. His touch tells him the condition of the depending portion of the uterus as an outlet, and also the condition of the organ as re- gards the power of expulsion. It determines the con- dition of the vagina as a parturient canal, and becomes so sensitive that it recognizes intuitively changes of • 140 STUDY OR DIAGNOSIS. condition that will render the labor painful, protracted, or difficult. In diseases of women, many physicians. rely upon the sense of touch far more than sight, and very rarely use the speculum. The finger tells the condition of the uterus, not only as regards position, but pathological changes as well. It determines dis- eases of vagina, bladder, rectum, indeed of all these parts, and does it so well that it becomes our most re- liable guide to treatment. I will guarantee that there is not one medical reader but what could to-day, blindfolded, determine better by simply placing his hand on the patient what kind of a bath should be employed, or whether any at all, than he can with his eyes open and without the touch. Try the touch in cases of intestinal disease, shutting your eyes to shut out ordinary impressions, and you will be astonished at the result. Pass the hand over the abdomen and at once you know whether a diarrhoea is irritative or atonic, and a correct treatment is sug gested. You may determine the character of a dys- pepsia in the same way, and the general outline of treatment. You can locate the disease and determine its kind. Even in uterine disease the abdominal touch becomes important. Try a case of pneumonia-let the hand rest on the chest, slowly passing it over, and you will be surprised to know how much may be learned- a Winter's practice, and it becomes a means of physical diagnosis. A most excellent way of making this study is to take a note-book and enter every question that may suggest itself with reference to the various sensations given to touch. Then question our experience-when and where have I met each of these? what has been the nature, 1 STUDY OF DIAGNOSIS. 141 progress, duration, and termination of the disease Now with what we know we will carry on a series of experiments in every case of disease, making use of what we have for the benefit of the patient, and learn- ing what we can for the advantage, of others in the future. -- Let me put a few questions which will serve as an example. If I put my finger on the tongue, and find it dry, contracted, or rough, would you give Podo- phyllin? an emetic? Quinia? Opium ? or a stimulant? If I put my hand on the abdomen and find the walls tense and contracted, the patient having diarrhoea, what will be the remedy? If relaxed and tumid what? If in uterine disease the abdominal wall is tense and contracted, what is the nature of the disease? If all the tissues are soft, full, doughy, what? If the hand placed upon the forehead gets the sense of relaxation and moisture, what would be the character of a head- ache? If the forehead was tense and dry, what? I offer these as examples of questions that one may ask himself, and as the reader will see they can be greatly varied, and asked of every part of the body, as well as of the body as a whole. Ask then with reference to the conditions of disease, but especially with reference to remedies, as the diagnosis that suggests treatment is that which we want especially. In a case of labor, if the examination shows constric- tion with want of secretion-pinched expresses the con- dition of the parts, both of the lower segment of the uterus, vagina, and perineal tissues—we know we will have a protracted and difficult labor. If the hand is placed upon the abdomen over the uterine globe and we get the same sensation of unnatural contraction- 142 STUDY OF DIAGNOSIS. pinched-there is possibly rigidity of os, or perineum; what is the remedy? You answer Lobelia, because it is the common remedy for rigid os and perineum. But you give it without any advantage, and it sometimes causes a very unpleasant irritation of the stomach and nervous system, and makes things worse rather than better. Let us ask your hand in place of your head. If this was a headache, and you had a similar sensation when your hand was placed on the patient's forehead, what would you give? You answer promptly, Gelseminum good, then give Gelseminum and not Lobelia. If upon examining muscular tissues you had the same unplea- sant sensation of contraction and irritability with pains. what would you give? Aconite or Veratrum with Macrotys-good, give Aconite and Macrotys in this case. If in chronic disease of the pelvic viscera we ob- tained the same sensation as the hand rested upon the lower abdomen, what would we give? Gelseminum, Aconite, Macrotys. If in this examination during tedious labor, we found the tissues thick and doughy, with rigid os and rigid everything else, what would we give? With this con- dition shown by an internal examination, the hand placed upon the abdomen would receive the same sensa- tion of unnatural fullness and want of action. Here we would give Lobelia. The touch tells the story clearly and explicitly, and names the remedy, which we find upon trial acts "specifically." Supposing now it should be pneumonia or bronchitis, and the hand placed upon the chest gets the same sensation of unnatural fullness, would the remedy be Lobelia ? Or if the finger placed upon the tongue obtains the sensation of doughy fullness, or the eye obtains it, would the remedy STUDY OF DIAGNOSIS. 143 E be Lobelia? Most assuredly, unless something else acting in the same way is more prominently indicated by other symptoms. In speaking of the touch as a means of diagnosis, we must not omit to notice the lesions of nutrition and excretion-supply and waste. How do you determine impaired nutrition? Surely not by the fullness or lean- ness of the face? if you do you are frequently mistaken You want to know if the loss of size and weight is from want of fat or muscle, and your hand at once seeks the covering of the false ribs for the one, and grasps a group of muscles-say of the arm, for the other. It would be absurd to feed a patient with beef tea or other histogenetic material if we wanted fat, though we might give calorifacient food to to save tissue. We not only get the evidence of impaired nutrition by the touch, and the food designated, but it tells us of medicines that will prove curative. If the sensation be of want of tone-tissues loose and flaccid-we think of Bitter Tonics, Quinine, the Hypophosphites, and Iron. If the sensation be of structures pinched and stringy, we look for lesions of the nerve centres, and think of Macrotys, Muriatic and Lactic Acids, Phosphoric Acid, fatty inunction, etc. The sensation of fullness without elasticity, would suggest old tissues, and the necessity of active waste, and would suggest Acetate of Potash, Iodide of Potas- sium, and stimulant cathartics and diaphoretics. If digestion remained good, these might be sufficient, for the tissues would be renewed as fast as broken down. But if their use gave soft and flaccid tissue, we should supplement them by such a restorative as the triple 144 STUDY OF DIAGNOSIS. phosphate of Quinia, Strychnine and Iron-"Com- pound Tonic Mixture." We would never give Iodide of Potassium in second- ary syphilis, where the tissues give the pinched and stringy sensation to the touch. Such a case would ask for Veratrum, Cod Oil, Iodide of Ammonium, and some would say Arsenic. Let one of those cases of secondary syphilis, characterized by full, inelastic, lifeless tissues fall into the hands of the routinist who prescribes Pro- toiodide of Mercury in all cases, and he loses appetite, digestion and blood-making, and grows worse rapidly. This is but an imperfect and partial sketch of one of our means of diagnosis, and one that has been regarded as least useful. Yet it points out the method of rational diagnosis, and the one we purpose studying in consid- erable detail. As the reader thinks of the subject, and recalls and arranges his experience, he will be surprised how much he knows practically, and still more sur- prised as he puts it in practice intelligently, how it aids him in the selection of remedies. • THE PULSE. Among the most important of the functions of life is a normal circulation of blood, indeed it seems to serve as a basis for the performance of all other functions. Healthy life is dependent upon a regular and uniform circulation of blood, and disease must follow any con- siderable or continued variation in this function.* *If the finger be placed upon an artery, such as that at the wrist, what is termed the pulse will be felt; that is to say, the elastic artery dilates somewhat, at regular intervals, which an- STUDY OF DIAGNOSIS. 145 1 Whilst the heart is the centre and principal source of power of the circulation, every vessel does its part in aid of the movement of the blood. We have, there- fore, to determine by the pulse the condition of the heart, the condition of the arteries, the condition of the capillaries, and to some extent the condition of the veins. As these movements are stimulated and co-or- dinated by the sympathetic nervous system, it should also tell us of wrongs of innervation. As the move- ment of the blood depends, to a certain extent, upon its organization and condition, it may also determine for us something of the wrongs of this fluid. We will probably study the pulse to better advantage if we analyze it, and think of its elements separately. Put your finger on the radial artery and carefully ob- serve the movement. It first divides itself into: (a) a swer to the beatings of the heart. The pulse which is felt by the finger, however, does not correspond precisely with the beat of the heart, but takes place a little after it, and the interval is longer the greater the distance of the artery from the heart. The beat of the artery on the inner side of the ankle, for exam- ple, is a little later than the beat of the artery in the temple. The reason of this is that the sense of touch by finger is only delicate enough to distinguish the dilatation of the artery by the wave of blood, which is driven along it by the elastic reaction of the aorta, and is not competent to perceive the first shock caused by the systole. But, if, instead of the fingers, sufficiently delicate levers were made to rest upon any two arteries, it would be found that the pulse really begins at the same time in both, the shock of the systole making itself felt all over the vascular system at once; and that it is only the actual dilatation of the arterial walls, which, traveling in the form of a wave from the larger to the smaller arteries, takes longer to reach and distend the more distant branch.-Huxley. 13 146 STUDY OF DIAGNOSIS. dilatation of the artery, and (b) a succeeding contrac- tion The wave of blood forced forward by contraction of the ventricles, gives us the arterial dilatation, whilst the contraction of the artery may represent the subse- quent filling of the ventricles from the auricles. To this extent the pulse evidences the time of con- traction, or the rapidity of heart-beat. Even to this extent the information is important, for a healthy life can only be maintained when the movement of the blood is well timed. If the heart beats too rapidly, we must have a wrong in the life, as if it beats too slowly we will have a wrong in the life. With regard to frequency of pulse we are in the habit of saying-as is the frequency so is the impairment of all the vegetative functions-of the appetite, digestion, blood-making, nutrition, excretion from skin, kidneys and bowels-wrongs of the blood, the activity of zymotic poisons, etc. There may be exceptions to this general rule, but it is so constant that we find it important to act upon it in every case of disease. Given, frequency of pulse, the questions at once suggested are-what is its cause? what is the remedy? Whilst frequency of pulse suggests to us the use of that class of remedies called sedative (special or arte. rial sedatives), they will not always answer our pur pose. If the wrong be purely one of the circulatory apparatus, functional in its character, and depending upon a wrong of sympathetic innervation, these reme- dies will probably be sufficient. But if the frequency of pulse represents and is dependent upon some other lesion, as of the blood, or local disease, then other and different remedies may prove the sedatives. Frequency of pulse is associated with frequent respi- STUDY OF DIAGNOSIS. 147 ration. The proportion is usually five beats of the pulse to one respiration. Thus an adult man in the sitting position will make thirteen to fifteen respirations. each minute, and the proportionate pulse will be sixty- five to seventy-five beats per minute. With a pulse of one hundred and ten beats per minute, we will have twenty-two respirations per minute. The relation of frequent respiration to various wrongs of function wil: be known to the reader, and evidently a slower respi ration is something to be desired in all cases of disease, and something that must be obtained in some cases if the patient recovers health. Without reference to the undue general excitation that comes from frequent respiration, and the exhaus- tion that must follow this severe muscular work, I would call attention to the marked wrong it must work in diseases of the respiratory apparatus. Rest is an essential to recovery in all diseases of excitation, and in most diseases of structure. With a rapid pulse, we can not have rest of the respiratory apparatus, for the movement of the chest is related to the movement of the blood. Make the pulse go slow, and the movement of the chest is likely to be slow in proportion. The relation between the frequency of pulse and the temperature will be borne in mind. For each increase of ten beats per minute of pulse, there is an increase of one degree in the temperature. Thus with a normal circulation of seventy beats per minute, and a normal temperature of 98°, we will find an increase of pulse to ninety will give a temperature of 100°; with an in- crease of pulse to one hundred and twenty we will have a temperature of 103°, and so on. This rule does not hold good in all cases, possibly not in the majority, for 148 STUDY OF DIAGNOSIS. the high range of temperature, from 103° to 108°, does not carry the pulse up proportionately. When we come to consider the influence of changes of temperature we find them similar to those that follow change in the time of pulsation. In the ratio of increased temperature we find arrest of excretion, of nutrition, of digestion, of blood-making, and of inner- vation, and that zymotic poisons propagate themselves more rapidly. With the temperature maintained above 103°, death is a matter of time, indeed molecular death is going on from the time the temperature strikes this point. It was mentioned that local processes of disease are severe in proportion to the frequency of the pulse. This will be noticed especially in inflammation-as is the frequency of the pulse so is the intensity of the in- flammation, the impairment of the life of the part, and the danger of a termination in death. The local hyper- æmia is increased by the rapid pulse, and the final arrest of circulation is also promoted by it. If, there- fore, we wish to stop the process of inflammation, we select those remedies which will lessen the frequency of the pulse. If in any case we have a structural lesion, whatever may be its nature-either an impairment of nutrition, or from deposit—we will find, frequently, that its pro- gress will be in proportion to the rapidity of the pulse. In these cases remedies that influence the circulation, giving it normal frequency and freedom, will be very important. It was also named that zymosis or sepsis was rapid in proportion to the frequency of the pulse. This may be noticed in those diseases known as typhoid, in ery- STUDY OF DIAGNOSIS. 149 sipelas, the eruptive fevers, diphtheria, as well as in typhoid and typhus fever. As is the frequency of the pulse, so is the evidence of sepsis, as marked by dirty, brown, or black coatings on the tongue, sordes on the teeth, pungent heat, offensive discharges, etc. The danger to life is frequently in proportion to the fre- quency of the pulse, and means that will give a better circulation as regards time, freedom, and uniformity in all parts of the body, lessen these unpleasant symptoms. But frequency is only one of the wrongs of the cir- culation, and but a part of the information we should obtain from the pulse, Frequency has reference to the rapidity of the blood-waves-the number that passes under our finger in one minute. In addition to this we have to notice that there are peculiarities in the blood- wave, and in the current after this wave has passed. The pulse has volume-referring to the size of the artery. It has varying impulses in the wave of the blood, and also in the interval between the waves. Volume, or increased size of the artery may have reference to the amount of blood, to its increased circu- lation, or to some obstruction to its free movement. We will have a large pulse in the plethoric, we may ex- pect a small one in the anæmic, and these conditions will be determined by other evidences. If the artery is large, and the person is not plethoric, we ask the question-is it dependent upon a more rapid movement of the mass of the blood, especially to the surface, or is it dependent upon an obstruction to its movement through the capillaries? Freedom in the pulse-wave in- dicates the one, and a want of freedom-oppression- indicates the other condition. 4 150 STUDY OF DIAGNOSIS. f The sharp impulse of the wave of blood, as it strikes the finger, may be referred to lesions of the nerve cen- tres, especially of the sympathetic. The wrong is of irritation, and calls for remedies that relieve it. If the impulse be sharp, the wave short, and the inter-cur- rent vibratile, the irritation is extreme. The dull, elastic stroke of the wave refers us to an impairment of innervation from the sympathetic and spinal cord. The more marked this is, the greater the necessity for those remedies which stimulate and give strength to these nerve centres. The length of blood-wave has reference to that con- dition known as (6 sthenia," an excitation founded on strong life. This is especially the case where the wave is large in volume, and well supported by the column of blood behind. The oppressed pulse is marked by a want of power in the stroke, and more especially by a feeling as if the current in advance of the wave broke its force. Evi- dently the blood-wave does not measure the amount of blood passing through the artery. It refers us to ob- struction in the capillary vessels, or possibly an impair- ment of the large vessels as well, or a wrong in the blood unfitting it for circulation. If the finger be carefully trained it will notice a vari- ation in the surface of the wave, as well as in its length. Many times it is distinctly felt as two waves—a first sudden and short, and a second full, even and prolonged The first may be called the shock-wave, and the secon the systolic-wave which represents the movement of blood from the heart. The shock-wave sharp and pronounced may always be referred to undue excitation of the nerves distributed STUDY OF DIAGNOSIS. 151 upon the vessels, and an undue contraction or tension of their walls. The full, strong, systolic-wave may be referred to ex- citation of the heart and strength in its movement. The short, systolic-wave evidences a want of cardiac power, and especially of impaired innervation from the spinal cord and sympathetic. The inter-wave current sometimes gives valuable in- formation, and it is well for the reader to observe it carefully in health and learn its normal condition. We find in disease that it has more or less volume, has more or less strength, and has more or less of the vibra- tile quality. When we speak of a full pulse, we have reference to the inter-wave current as well as to the wave, and the condition of sthenia will be determined by this. It is strong life in a state of excitation. If now we add hardness, we have added an especial lesion of innervation, of excitation steadily maintained. If we speak of a small pulse hard, we refer it to im- pairment of life from activity, still maintained. If we have a small pulse soft and easily compressed, we refer it to deficient innervation. If we have a small pulse vibratile, we say it is the ex- pression of impaired life, with great excitation of the nerve centres. If we have an empty pulse, the inter-wave current hardly perceptible, it is the evidence of impaired life, with enfeebled innervation from the sympathetic. There are other changes of the pulse which might be noticed, but they are difficult to describe and learn I do not think that we can tell every lesion by it, as Chinese doctors believe, but to the educated touch } [ 152 STUDY OF DIAGNOSIS. gives most valuable information with regard to the most important functions of life. I doubt not many physi cians can locate lesions with very great certainty from it alone; that they can distinguish lesions of the brain, lungs, digestive apparatus, urinary apparatus, etc., and determine, to some extent, their character. But in the practice of medicine, there is something of more importance than locating a disease, or even de- termining the character of the lesion. The important object is to associate the evidences of disease with reme- dies for their cure, and to make the expressions of dis- ease point to the medicine. Feeling the pulse gives us a knowledge of the lesions of the circulation-most important information in the majority of diseases. Every lesion of the circulation is distinctly announced to the cultivated touch, as is some lesions of the blood and of the nervous system. In so far as we study the pulse, I desire that it shall mean special remedies-not names of disease. Frequency calls attention to a wrong of the circulation and prompts the asking of the question-why? It does not necessarily mean Veratrum, Aconite, Gelsemi- num, etc., though it is suggestive of them Why? Is the wrong in the vessels an obstruction to the free circula- tion of blood, requiring an increased movement of the heart to compensate it? Is the wrong an enfeeblement of the heart, requiring increased frequency of impulse to compensate for want of power? Is the increased frequency dependent upon irritation of the cardiac plexus? Is the frequency dependent upon a wrong of the blood? Upon a cerebro-spinal wrong? The full pulse with strength means medicine-Vera- trum. Whether full and hard, full and bounding, the 1 STUDY OF DIAGNOSIS. 153 special sedative named is at once suggested. It may not be all that the patient wants, but it is one, and in many cases will stand first. The full pulse doughy (lacks the marked vibration) means Lobelia ; or if marked and associated with full- ness of mucous membranes and purplish discoloration, Baptisia; or if accompanied with muscular pain, Apo- cynum. The full pulse open, is kindly influenced by Podophyl- lin, and especially by Quinine in full doses. The large pulse empty calls for the alkaline sulphites, Sulphurous Acid, stimulant baths or fatty inunction, Quinine, and histogenetic food. The sensation we get in this case is of an artery of large calibre, but with too little volume of blood-the sensation after the impulse being of emptiness. The full pulse vibratile calls for Gelseminum, usually associated with Veratrum. The full pulse oppressed, calls for Belladonna, alter- nated with Veratrum; if sepsis, Baptisia. The small pulse usually means Aconite. The small pulse vibratile Aconite and Gelseminum. The small pulse oppressed Belladonna and Aconite. The small, soft, easily compressed pulse, Aconite, stimulants. Small doses of Quinine with Opium and food. The small pulse, frequent, easily compressed, the wave of blood giving a sense of squareness as it passes under the finger, Opium. Want of power in the impulse suggests Digitalis, Capsicum. The sharp stroke of the pulse with tremulous wave be tween strokes, means Rhus. } 154 STUDY OF DIAGNOSIS 13 The sharp stroke of pulse, with even, small, vibratile current between strokes-Bryonia. The duil stroke with tremulous or vibratile wave- Phytolacca. The open, tremulous pulse-Arsenicum. The small or open pulse in which the wave of blood drops suddenly as it passes the finger-Pulsatilla or Cactus. Irregularity of pulse, soft or open, with a distinct wrong in the stroke-Cactus. The steady, vibratile pulse, without marked wave- Macrotys. We have often reason to believe that Quinine is indi- cated by the periodicity of the disease, and yet our ex- perience with the remedy raises doubts of whether it will be well received and exert a kindly and curative action. If the pulse is hard and vibratile, wiry, we will not give it; if it is soft and open we may expect its kindly action. The physician who would administer Opium or its salts with a hard, wiry pulse, would be doing his patient a great wrong. Here, also, we want a soft, open pulse for the kindly action of the medicine. No one in his senses would give Podophyllin when there was a small, wiry pulse, or when it had a sharp stroke-the patient might get through safely, and it might kill him. This is only a partial consideration of the subject, · and the results of my own experience. It should agree with what others know of the pulse as a means of diagnosis, and I hope will be thoroughly proven. Even if proven to be without foundation in fact, the investigation will give practical knowledge, and will increase our knowledge of the relationship between the evidences of disease and remedies. STUDY OF DIAGNOSIS: 155 If the reader will notice carefully, he will see a marked resemblance between the touch of the pulse, and the general sense of touch when the hand is applied to the skin. The sensation from the slight œdema of cellular tissue, that indicates Apocynum, and the pulse that says Apocynum is wonderfully similar. The sen- sation from the skin that says Lobelia and the pulse that says Lobelia is the same. The pulse of Veratrum is associated with the skin of Veratrum. And so we will find it all the way through, if we see the indica- tions for remedies rightly they never conflict. THE TEMPERATURE. Among the evidences of disease, none are more defi- nite and important than changes in the temperature. Heat is not only force in the animal body, but it is also a condition of life; a man has activity through it, and: he has life by it. The theory of Samuel Thomson- "Heat is life, cold is death," was very simple, and had much of truth in it—it was just one-third of the truth. Cold is death, but so is too high a temperature, and an unequal distribution of heat. The human body maintains its healthy functions at a temperature varying from 98° to 98.5°. This is a con- dition absolute for health. If the temperature varies from this above or below, disease must result. We may state the proposition in a different form-no disease can exist without changing the temperature of the body, either raising it, depressing it, or rendering it unequal. Thus, change of temperature becomes an absolute evidence of disease, though it may not point out the character or the location of the lesion. 156 1 STUDY OF DIAGNOSIS. In the olden time changes in the temperature were determined by the hand applied to the surface of the body. With some physicians the touch would be so educated that it would recognize these changes with considerable accuracy. Whilst it would not note the changes within one or two degrees when the tempera- turé was above, it would recognize certain alterations. of the skin, and modifications of heat or electricity, that the body thermometer does not take cognizance of. This information is of great importance, and whilst we highly value the body thermometer, we purpose to cultivate the touch as far as possible. THE BODY THERMOMETER.-The thermometer is pre- sented to us as a new means of diagnosis, but as far back as 1754, one hundred and twenty years ago, An- tonius De Haen, the first clinical teacher of medicine at Vienna, insisted upon its use to determine the tem- perature of the body, rather than to judge by the hand. But though De Haen showed that it was the only cor- rect index of heat, and seemingly indispensable in diagnosis, if it was desirable to determine the temper- ature, he was not able to convince the profession that this was desirable, and its use lapsed with his death. The use of the thermometer has been revived within the last fifteen years, and is now exciting much attention, and is employed by many as a most valued means of diagnosis and prognosis. It is valued now, because we appreciate the fact that the vital processes can only be performed in perfection at the normal temperature of 98º, and that just in proportion as it varies from this, either above or below, they are changed or arrested. Indeed, it would seem, that heat, at this degree, was the STUDY OF DIAGNOSIS. 157 most essential condition of life, and that if there be a variation from it, those means which will restore the thermal equilibrium are the most direct and important. The difficulty in the way of using the thermometer to determine the temperature of the body, seemed to be in a want of sensitiveness, and precision in marking fractions of a degree. This has been overcome by em- ploying a large quantity of mercury in the bulb, and a short stem graduated from 80° to 115°. By thus in- creasing the quantity of mercury, the degree, as marked upon the scale, was so lengthened that it could readily be divided into fourths, and even eighths or tenths. And the sensitiveness to heat was in direct proportion to the increased length of a degree as marked upon the scale. A registering thermometer is one in which a small por- tion of mercury is detached from the main column in the stem of the instrument. This detached portion is elevated by the expansion of the mercury below, which ascends in the stem below it, and thus marks the degree of heat. But it is not influenced by the descent of the main column, but remains in its place, thus acting as a register. In using this thermometer, the detached por- tion of mercury is lowered in the stem below the register by giving it three or four gentle taps with the hand from below. As the instruments require great accuracy in manu- facture, they exceed in price the ordinary thermometer. Yet very good instruments may be purchased for $2.50 to $5.00; the self-registering, in morocco cases, 1 would recommend as preferable. It may be remarked, that we employ thermometers graduated to Fahrenheit's scale, but some of the 138 STUDY OF DIAGNOSIS. cheaper German instruments have the scale of Reaumur or Centigrade. The majority of APPLYING THE THERMOMETER. writers direct that the thermometer be applied in the axillæ, as it is there completely enclosed and sur rounded by the soft parts. When it is convenient, as in some acute diseases, the person being in bed, I think the axillæ the best, yet there are many cases when we should like to test the temperature, that it would be very inconvenient for the person to unfasten the clothes to reach this part. Women, especially, will object to this method of examination. To suit these cases, I apply the bulb of the ther- mometer under the tongue, having the patient close. the mouth. This is much more convenient, and so far as my experience extends, just as reliable. The thermometer should be retained in its place from three to five minutes, as it requires this length of time for the full influence of the body's heat. It is well also, in some cases, to watch the register to see how rapidly the mercury rises, as there is much difference in this in different cases, and it also becomes an element in diagnosis. RANGES OF TEMPERATURE IN HEALTH.-The standard temperature of the healthy body is 98.5°, and is sub- ject to a slight variation during the day of about 0.820°. The maximum temperature is in the early morning; it fluctuates and gradually decreases during the day, and is lowest at midnight. "The observations of Drs. Edwards and Davy have shown that the amount of animal heat may be consid- erably altered by a number of collateral circumstances. STUDY OF DIAGNOSIS. 159 But the great distinction between these alterations of temperature in health, and those which are the result of disease is, that these variations are generally tempo- rary, and within narrow limits-amounting to mere fractions of a degree-rarely more than 1.8° Fahr. to 3.6° Fahr. whereas those which are due to disease are persistent so long as the disease exists. "The following are the collateral circumstances which mainly influence animal heat in our daily life, and which require to be remembered in order that erro- neous conclusions may not be drawn: 1. Active exercise [not carried to the extent of exhausting fatigue] raises the temperature proportionally to the degree of mus- cular exertion made. 2. Exposure to cold without exer- cise lowers the temperature. 3. Sustained mental ex- ertion reduces temperature about half a degree 4. The amount of heat is also reduced by a full meal and the use of alcohol; but it rises again as digestion advances. 5. There are diurnal fluctuations capable of being thus determined. 6. The temperature of the body rises with the temperature of the air; and sudden transitions. from a cold to a hot climate induce a feverish state marked by increase of temperature on bodily exertion. 7. The average temperature within the tropics is nearly 1° Fahr. higher than in temperate regions. 8. The temperature is more readily and rapidly affected-more sensitive, so to speak-than either the pulse or the res- piration; and this is especially the case in disease.". Aitken. RANGES OF TEMPERATURE IN DISEASE. We have to study both an increase and a decrease in the temperature of the body, the first being of most common occurrence. 160 STUDY OF DIAGNOSIS. 1 and having the greatest range. Thus whilst a decrease of but one degree, if maintained for a considerable time, will result in death, an increase of two to four degrees may be maintained for a month with safety to life. The increase of temperature is usually proportionate to the frequency of the pulse, one degree corresponding to an increase of ten beats per minute. Thus : With a temperature of 98°. ..pulse of 60 "L 6 99° (6 100°. ( 101°.... 102°. แ " 103°...... ce (( 104°... (( แ 105°... (6 106°.... (( 70 "L 80 แ 90 (( 100 46 110 120 130 140 This table is for adult males of good development, and will not apply to those of feeble constitution, of sedentary habits, or of a nervous temperament. In such, with a normal temperature of 98°, the pulse would be 70 or 80, and the increased frequency to each degree would be but six or eight, until the 103° was passed. In chronic disease we also find an increase of tem- perature, and the thermometer becomes almost as cer- tain a means of diagnosis and prognosis as in febrile and inflammatory affections. Thus, for instance, in phthisis pulmonalis, we find a permanent increase of temperature to 99° and 100°, in the first stages, in creasing to 101° and 102°, as the disease progresses. This increase is so uniform that it will furnish the best. evidence of the nature of the disease in its earliest stage. The frequency of the pulse corresponds to the increase 1 STUDY OF DIAGNOSIS. 161 ". of temperature. Breaking down of the tubercles is announced by a marked increase of temperature, cor- responding to the destruction of lung tissue, and the danger to life. In acute fevers and inflammations, we find the tem- perature increasing in the ratio of the severity of the disease. It does not, however, remain uniformly the same throughout the twenty-four hours, but presents a marked morning decline and evening elevation. This is very distinct, even in continued fevers, which we are accustomed to think of as being uniform in all their phenomena. This fluctuation is rarely less than one degree, and is frequently two degrees or more. The value of the thermometer, as a means of diag- nosis, is thus estimated by Dr. Aitken: "In the course of many diseases, whose diagnosis has been accurately determined, if the temperature de- parts from its normal or typical range, the thermometer will furnish the best and the earliest indication of any untoward event, such as the additional development of disease, or other visceral complications, in its course. "When once the typical range of temperature (nor- mal, as it were, of the particular disease) is determined, a basis is laid for appreciating irregularities or compli- cations in its course in particular cases. For example, a patient exhibits symptoms of fever of the typhoid type, but during the progress of the first week his tem- perature becomes normal, for however short a space of time-the occurrence of this event proves that the fever is not what it was supposed to be. Again, a patient may suffer from all the general symptoms of incipient pneumonia; but there still is a doubt as to whether in- farction of the lung has taken place. The sputa being 14 162 STUDY OF DIAGNOSIS. * · suppressed, or not procurable, does not assist the diag nosis. If, however, the temperature is found to be normal, it is certain that no croupous exudation has taken place in the lung, and that there is no pneumonia. Again, if a tuberculous patient has a sudden attack of hæmoptysis, and if the temperature of his body is normal during and subsequent to the.attack, no reactive pneumonia, nor any exacerbation of the tuberculous exudation need be expected. This is a new field open for investigation in cases of phthisis. Again: In all cases of convalescence, so long as the defervescence proceeds regularly, as measured by the temperature, no relapses need be feared; on the other hand, delayed defervescence in pneumonia, the persist- ence of a high evening temperature in typhus or typhoid fever, or the exanthemata, and the incomplete attainment of normal temperature in convalescence, are signs of great significance. They indicate incom- plete recovery, supervention of other diseases, unfavor- able changes in the products of disease, or the continu- ance of other sources of disturbance requiring to be carefully examined into. The onset of even a slight elevation of temperature during convalescence is a warning to exercise careful watching over the patient, and especially for the maintenance of a due control over his diet and actions.” THE INFLUENCE OF TREATMENT ON THE TEMPERA- TURE.-By reference to table on page 160, it will be noticed that there is a constant relation between the frequency of the pulse and the temperature: that with a range of temperature of 103° to 105°, we find a pulse ranging from 110-115 to 130-140. It is evident, there- STUDY OF DIAGNOSIS. 163 fore, that if we have any means that will control the circulation lessening the frequency of the pulse-it will also lower the temperature. The question then arises, if a treatment will thus control the pulse and temperature, may it not change a severe and dangerous case into a mild one without danger? We answer this question in the affirmative, not as a theory, but from observations on many cases of disease. I think I am justified in stating, as an axiom, that just in the ratio that the circulation is thus controlled, and the temperature reduced, the fever is rendered mild. I wish it distinctly understood, however, that I refer only to those influences which can be continued for some days, and not to those which endure but a few hours. The use of large doses of Veratrum will bring down the pulse from 120 to 60 or 70 beats per minute, in six to ten hours, and with a corresponding reduction in temperature; but it is not possible to continue this influence, as in a few hours the stomach becomes irri- table and rejects it, or the depression of the sympathetic. nervous system is such as to peril life. But if the remedy is given in doses of half to one drop, sedation is slowly produced, the stomach receives it kindly, and instead of depression of the vegetative functions, the remedy acts as a stimulant to them. But is it possible to arrest a fever before it has run its course? I am satisfied that this question may also be answered in the affirmative. Not that every case can be shortened, for in some the local lesion of Peyer's glands proves an insurmountable obstacle; but many can be arrested from the seventh to the ninth day, more 164 STUDY OF DIAGNOSIS. by the fourteenth, and in nearly all the disease can be restricted to twenty one days. A fever terminates naturally-by a decrease in the frequency of the pulse, a diminution cf the tempera- ture, and the re-establishment of secretion, by which the cause of the disease is removed. If, then, by the use of sedatives, we lessen the frequency of the pulse, and obtain an equal and uniform circulation, with a corresponding decline in temperature, we find it easy to establish secretion from the skin, kidneys and bowels, by the usual means. And in a majority of cases these processes may be sustained by the use of nutritious food, and the use of small doses of the Bitter Tonics. But the question arises, does the temperature bear the same relation in chronic disease, and will treatment influencing the temperature have a like curative influ- ence? I answer the question in the affirmative, and adduce as an example phthisis pulmonalis, one of the most intractable diseases we have to contend with. In this, so long as the increased temperature is main- tained, the disease progresses; and very frequently its rapidity is in exact ratio to this. Diminish the temper- ature, and the disease progresses more slowly. Reduce it to 98.5°, and maintain it at this, and the patient re- covers. The wrong of temperature is but the expression of disease. If the disease is favorably influenced by rem- edies the temperature falls or rises towards the normal standard. Thus in a given case of disease we may see the pathological wrong, whether of the blood, the nervous system, or of waste and excretion, and at the same time the indications for the remedy which will STUDY OF DIAGNOSIS. 165 1 right the lesion, and we know that its use will reduce the temperature. Thus in a case of zymotic fever the evidences of sepsis are marked, and with sepsis there must be an exalted temperature. If now we select the right antiseptic, say Sulphite of Soda, Chlorate of Potash or Baptisia, the temperature will fall with its use. If in any given case we have a special indication for Nitric Acid, for Podophyllin, Quinine, etc., they will influence the temperature toward the normal standard. But in many cases the wrong of temperature may be regarded rather as a cause than as a result. If the temperature is above the normal standard the functions of life are impaired in the ratio of the excess. Thus as we have already seen-increase of temperature is asso- ciated with acceleration of the pulse-increase of tem- perature is associated with frequent respiration. With an increase of temperature there is an arrest of diges- tion, blood-making, nutrition, waste, retrograde meta- morphosis, and secretion from skin, kidneys and bowels. We also find that structural lesions are influenced in the same manner. Inflammation is active in propor- tion to increased temperature, as is also the tendency to suppuration and death of the part. The influence of zymotic causes of disease is also increased in the ratio of increase of temperature, and the condition known as typhoid is marked in proportion to it. In surgical disease we find the processes of repair arrested when the thermometer marks 103°; above this the pus loses its laudable character, becomes thin, ichorous, etc., and presently the structures soften and break down. The fact that increase of temperature is a condition 166 STUDY OF DIAGNOSIS. in many chronic diseases has already been noticed. In phthisis pulmonalis the first advent of disease is an- nounced by a temperature of 100°. In morbus coxa- rius, white swelling, etc., increase of temperature is one of the most pronounced and distinctive symptoms. In all these cases we may say that the rapidity of dis- ease is in the ratio of increased temperature, and so long as the temperature is thus high no amendment need be expected. If the temperature can be reduced and maintained at or near the normal standard, the de- structive processes are less active, and a cure rendered possible. • If we decide that a wrong of the temperature is a cause rather than a result, even though but in part, we wish to know the means by which it may be rectified. The first proposition-" as is the pulse so is the tem- perature”—gives us the use of the very important class of remedies-the special sedatives. If these rem- cdies exert a direct influence in giving a slower and better circulation, they will also lessen the temperature. Certain remedies especially influence the temperature through the nervous system, as Rhus, Gelseminum, Bryonia, Belladonna, Nux, Nitric Acid. Others influ- ence it through the constitution of the blood, as alka- lies, acids, food, etc. Then again we heat in the body. condition of this part, of this lesion. look to the skin as the regulator of It is possible that a wrong in the apparatus is the cause, in whole or What is the condition of the skin? Is it dry, constricted, full, relaxed? What remedies, in the form of baths, or otherwise, will right these wrongs? If we take the simple lesion of excess of temperature STUDY OF DIAGNOSIS 167 and frequency of pulse, as seen in febricula, we will find a cure in the cold wet-sheet pack, as we would in the early stages of a sthenic inflammation. Or in place of this the ordinary vapor bath or spirit-vapor bath might be employed. In many cases with a dry and constricted skin the sponge baths are found to place this organism in better condition, and lessen the tem- perature. If a bath is medicated, we select it as we would the internal remedy. If an alkali is indicated internally by pallid mucous membranes, it will be found best for a bath. If an acid is indicated internally by deep colora- tion of mucous membranes, we will employ an acid bath. If the skin is relaxed and enfeebled, we think of stimulant, tonic, or astringent baths. We employ fatty inunction in two conditions-when the skin is dry and constricted, and when it is relaxed and enfeebled— in both the inunction answers a good purpose. In some cases we combine with it a stimulant, or one of the essential oils; in others we make it a vehicle for the topical application of Quinine. If the increase of temperature is associated with waste of tissue, we find it important to provide a better fuel for burning, and thus allay the excitation caused by destruction of tissue. Thus in chronic disease wę think of Cod Oil, and foods that contain calorifacient material in excess, and that are at the same time easily digested. In acute disease we furnish similar kinds of food, whilst at the same time we modify the process of combustion as much as possible. In depression of temperature we find every function of life impaired, but in this case the lesion is always of depression, whilst in the preceding it was most fre 168 STUDY OF DIAGNOSIS. quently of excitation. It requires but a slight fall of temperature to impair and finally arrest functional ac tivity. With a depression of a single degree a man is sick, and if this is maintained death will result in from two or three days to a week. In some cases of chronic disease we find a slight de- pression of temperature, as a part of the lesion. At once we ask the question, what is the cause? Is it de- pendent upon want of food, or of proper food? A wrong of digestion? An impairment of the respiratory function, and of the burning? Or a wrong of the skin, so that it permits a rapid escape of heat? On the answer obtained to these questions, will depend the treatment. If it is a want of food, or of calorifacient food, a right treatment will look to the selection of appropriate kinds. If we find a lesion of digestion, either buccal, stomachic, or intestinal, means to rectify these lesions will be demanded. If it arises from deficient respira- tion, we will direct such exercise as will call into activ- ity the respiratory function, and facilitate combustion. It is possible there may be a defect in certain materials that favor combustion. Thus in some cases I have found the want to be of Phosphorus, and its administra- tion at once restored the calorific function. In others it may be of Sulphur, or of Soda, or in some cases it would be met by Cod-Oil. Wrongs of the skin, per- mitting the escape of heat, are readily recognized by the touch, as evidences of relaxation, of exudation of water from the blood, or hyper-activity of the sudori- ferous glands. The remedies will consist of stimulant and tonic baths, or sometimes the use of fatty inunction with stimulants or with Quinine. ་ STUDY OF DIAGNOSIS. 169 An irregular or unequal distribution of heat is a source of trouble as well as its increase or diminution. If we have too much heat in one place and too little in another, we will find associate wrongs of circulation and innervation, and there will be impairment of digestion, blood-making, nutrition, waste, retrograde metamor- phosis, and excretion. Wrongs of the blood are like- wise increased, and there is the tendency to deposits of imperfectly formed albuminoid material. Local dis- eases are also more severe, and the tendency to struc- tural changes more marked. • In chronic disease we will frequently find that no im- provement takes place until the wrong of temperature is rectified. Getting well may hinge on getting the feet warm. With cold feet, remedies which seem adapted to the case, continually fail; warm the feet, even by sprinkling Capsicum in the stockings, and the patient improves at once. In some of these cases topi- cal means will be all-sufficient, but in others we will have to employ such as give strength to the circulation and improve innervation. In acute disease unequal temperature is one of the most unpleasant symptoms met with, and it is always looked for in the advanced stages of severe disease. The experienced physician examines the patient's toes, his knees, his ears, the tips of his fingers, with as much interest, as he examines the pulse. If he finds coldness of these parts, he is at once awake to the necessity of every means for the conservation of life, whether it has reference to means to prevent undue expenditure, or such as will increase the forces of the body. Cold- ness of parts distant from the heart at once suggests the idea of alcoholic stimulants as food, to be supple- T 15 170 STUDY OF DIAGNOSIS 1 mented, as soon as may be by such foods as seem best adapted to the case. Changes of kind in temperature will not be recog nized by the thermometer, and hardly by the physiciar who prides himself on being "scientific." “Kinds of heat indeed! there is but one heat, and it is nonsense to try to make a distinction in kind” (?) This is all very well, but the practiced physician knows that there are kinds, at least in so far as his sensations are concerned, and that these "kinds" tell him of definite lesions, and point to remedies. We do not know just why we have varying sensations of kind, but we do even in warming apparatus. The sensation of heat is not the same from a coal stove, an open fire, hot water pipes, or a Dutch earthen-ware oven. And the sensation of heat by the hand is not the same in simple febricula, remittent fever, typhoid, typhus, yellow fever, scàrlet fever, etc. The kind is unmistakable, and becomes more and more so as the wrong of the blood and of the nervous system increases. If one applies the hand upon a surface from which a sinapism has been recently removed, a peculiar sense of "pungency" is experienced. Quite as distinct a sensation comes in severe scarlet fever, in malignant rubeola, and in diseases characterized by the symptoms known as typhoid. We get a similar pungent heat when there is great excitation of the sympathetic and spinal nervous systems. We may say then, that this character-pungent heat-which is so readily recog- nized by most persons, refers us to lesions of the blood— sepsis, and to lesions of the nerve centres-excitation. We at once think of antiseptics as appropriate reme- dies, and select the particular one by symptoms already STUDY OF DIAGNOSIS. 171 " named. In so far as the nervous lesion is concerned, we will be guided in the selection of remedies by the ´acial expression and by the pulse. It is possible many times, to determine the character of a local lesion by the sensation given the hand. Thus one very readily recognizes the peculiar pungent heat of erysipelas, and sometimes the touch will determine the advent of this lesion in surgical disease before the eye would recognize the change of color, or the intu mescence of tissue. The hand placed upon the abdo men will feel the advent of puerperal inflammation before it will be recognized by ordinary symptoms. There is very much to be learned in this regard, and it is well to give it thought and experiment. : DIAGNOSIS BY THE EAR. The ear may not be as important in diagnosis as the eye or touch, yet we purpose employing it to its fullest capacity. To the routine physician who asks questions and depends for his knowledge of disease upon what the patient tells him, it is the organ of greatest impor- tance. But we have already seen that we do best when we study disease with our senses, and depend but little upon what the patient says. If the reader will refer back to our study of facial expression, he will notice the statement that wrongs of life find expression through the usual channels of ex- pression; where the nerve currents have been most in the habit of flowing in health, they incline to flow in disease. Mankind use the facial muscles to express their feelings or sensations, and hence discase is ex $ 172 STUDY OF DIAGNOSIS. pressed in the face. For the same reason we should expect to find wrongs of life expressed in the voice, in all animals using the voice, and especially in man who finds it a principal instrument of expression.* *The character of the human voice, under the influence of various emotions, has been discussed by Mr. Herbert Spencer in his interesting essay on Music. He clearly shows that the voice alters much under different conditions, in loudness and in quality, that is, in resonance and timbre, in pitch.and intervals. No one can listen to an eloquent orator or preacher, or to a man calling angrily to another, or to one expressing astonishment, without being struck with the truth of Mr. Spencer's remarks. It is curious how early in life the modulation of the voice becomes ex- pressive. With one of my children, under the age of two years, I clearly perceived that his humph of assent was rendered by a slight modulation strongly emphatic; and that by a peculiar whine his negative expressed obstinate determination. Mr. Spencer further shows that emotional speech, in all the above respects is intimately related to vocal music, and consequently to instrumental music; and he attempts to explain the character- istic qualities of both on physiological grounds,—namely, on "the general law that a feeling is a stimulus to muscular action.” It may be admitted that the voice is affected through this law; but the explanation appears to me too general and vague to throw much light on the various differences, with the exception of that of loudness, between ordinary speech and emotional speech, or singing. That the pitch of the voice bears some relation to certain states of feeling is tolerably clear. A person gently complaining of ill-treatment, or slightly suffering, almost always speaks in s high-pitched voice. Dogs, when a little impatient, often make a high piping note through their noses, which at once strikes us as plaintive, but how difficult it is to know whether the sound is essentially plaintive, or only appears so in this particular case, from our having learnt by experience what it means! Rengger states that the monkeys (Cebus azarœ), which he kept in Para- STUDY OF DIAGNOSIS. 173 As we come into the sick room we give attention to the voice of the sick person, quite as much as we do to what he is saying. We find that it expresses strength and weakness, is free or difficult from local disease, and shadows forth the condition of the brain in its tone, which varies from the listlessness of atony to the quer- ulousness of excited feebleness, and the excitation of over activity. In studying the voice as the expression of disease, we recognize its three-fold bearing as it refers us to a general impairment of life, a lesion of the brain, and to lesions of the respiratory asparatus. If we did not keep these sources of wrong in view we might make serious mistakes. If, for instance, we have feebleness of voice, it may be due to general impairment of life, to impairment of the functions of the brain, to deficient innervation from the spinal cord, or to a lesion of the respiratory apparatus. Whilst strength of voice is usually regarded as evi- dence of good vital power, and a good respiratory ap- paratus, it will not do to place too much dependence guay, expressed astonishment by a half-piping, half-snarling noise; anger or impatience, by repeating the sound hu hu in a deeper, grunting voice; and fright or pain, by shrill screams. On the other hand, with mankind, deep groans and high piercing screams equally express an agony of pain. Laughter may be either high or low; so that, with adult men, as Haller long ago remarked, the sound partakes of the character of the vowels (as pronounced in German) O and A; whilst with children and women, it has more of the character of E and I; and these latter vowel-sounds naturally have, as Helmholz has shown, s higher pitch than the former; yet both tones of laughter equally express enjoyment or amusement.-Darwin. ! 1. 174 STUDY OF DIAGNOSIS. 5 upon it in these regards. It certainly evidences good innervation from the brain and spinal cord. But if these nerve centres are sound, active, and well supplied. with blood, we may have a strong voice, even though the body at large is nearly exhausted. Usually it is a favorable symptom. Feebleness, on the contrary, evidences a lesion of atony, either of the body at large, of the brain or mind, of the spinal cord, or of the respiratory apparatus. Whilst the probabilities are in favor of its being a nervous lesion, we will not take it for granted, but make such examinations as will localize the lesion. Feebleness. simply, without querulousness, suggests the use of Phosphorus, the Hypophosphites, Cod Oil, Alcohol as food, Iron, Arsenic, Quinine. If it is associated with a marked effort from the will, and a sighing respiration, we refer it to deficient innervation from the spinal cord, and think of Strychnia, Ergot, or Suntonine as reme- dies. In lesion of the respiratory apparatus there will be change in the voice other than feebleness. It is difficult to give a name to the peculiar expres- sion of voice associated with nervous irritation and vas- cular excitement, yet the reader will learn to recog- nize it readily, and may frequently be able to deter- mine these characters of disease by simply hearing the patient speak. There is a sharpness, and want of smoothness, representing pretty accurately in degree the amount of disease. The halting voice, evidencing a labored action of the brain, tells the story of congestion, and suggests the use of Belladonna, or if markedly halting, of Lobelia The oppressed voice, hollow and unsteady, evidences. a general impairment of life, and calls for stimulants, tonics and food. STUDY OF DIAGNOSIS. 175 The oppressed voice from the upper part of the lungs suggests deficient innervation to heart and respiratory apparatus, and causes us to think of stimulant doses of Lobelia. Sharpness of voice suggests nervous excitation, and will sometimes point to the remedy, as in the peculiar sharp accentuation of the Rhus voice, resembling the cry encephalique of the child. The cry of the child will frequently inform the phy- sician of the location and character of the disease. Of course we recognize the fact that there may be but little change in the cry, or that there may be changes without corresponding disease, but we have other means of diagnosis to supplement this, and prevent error. Physicians who have given this subject atten- tion will recall the peculiar cry of abdominal distress, the change which marks disease of the respiratory ap- paratus, the oppressed cry of congestion, the shrill, metallic cry of inflammation of the brain, etc. It does not take much observation to distinguish the cry of disease from the cry of hunger, or anger. In the preceding paragraph a peculiar cry, encepha- lique, was noticed, which is so distinctive that it will never be mistaken. 1ts suddenness and shrillness is characteristic. In its slighter forms it arises from cerc- bral irritation and determination of blood, and calls for Gelseminum as the remedy. When marked and shrill, I should always think of Rhus Toxicodendron as the remedy. A sudden cry, followed by sobbing respiration, is a prominent indication for Bromide of Ammonium.. The voice is the function of the larynx, and its changes will point us to disease of this organ. The } 176 STUDY OF DIAGNOSIS. croupous cry and voice is quite as distinctive as the croupous cough. If it evidences moisture, we have mucous croup; if it is dry and metallic, pseudo-mem- branous croup; if variable in tone and character, spas- modic croup. In chronic disease of the larynx, roughness of the voice is one of the first symptoms. As the disease pro- gresses, we have various changes in the voice and dif- ficult use of it, as characteristic symptoms. In chronic bronchitis we also find change, but not similar in kind. It may give the voice shrillness, as in irritative bronchitis, or dullness, hollowness, or rever- beration, as in asthenic bronchitis. COUGH. Whilst cough calls our attention to a prob- able disease of the respiratory apparatus it does not in- dicate with any certainty the character of the disease. But even to this extent it is important, for it is possible. to overlook local disease, from the prominence of gen- eral symptoms. Whilst cough is usually the expression of discaso of the respiratory apparatus, it may have its origin in other diseases. Thus we find cough from gastric, biliary and intestinal lesions, and from disease of the nerve centres, and our examination is made with reference to these probable causes in obscure cases. Cough is the expression of irritation, and comes, from the sense of an irritant material in the respiratory pas- sages, which it is intended to remove. But many times there is nothing to be removed-it is a misconception of the respiratory nerves, which suffer from irritation, and we wish to determine whether or not the effort is to be favored. In the larger number of cases expecto- r. # STUDY OF DIAGNOSIS. 177 ration is undesirable, and if we remove the irritation of the nerves the cough ceases. A little attention upon the part of the physician will determine this point, as it is quite easy to distinguish the cough necessitated by increased secretion, and at- tended by expectoration, from the inefficient, rasping cough of irritation. In either case, but especially in the last, an effort of the will is of marked benefit in checking cough. The character of the cough expresses to some extent the condition of the respiratory passages. If dry, ringing, metallic, we think of irritation, determination of blood, and arrest of secretion, and the remedies at once suggested are those which allay irritation, check determination of blood, and favor normal secretion. If moist, rattling, gurgling, dull, stimulants to the res- piratory passages, as well as remedies to relieve irrita- tion are suggested. A cough is more or less forcible, and more or less easily under the control of the patient. If forcible, not under control, or explosive, we at once suspect a wrong of the nerve centres, usually of the basilar brain, and select remedies accordingly. Of course we may have such uncontrollable cough from local irritation, especially of the throat, but this will be readily recog- nized by the expression, as well as from the patient's sensations. A cough has more or less evidence of strength, both of the respiratory apparatus, and of the body at large. The strong, well sustained cough may be a source of annoyance, but evidences good vitality and a naturally good condition of the respiratory organs. A feeble cough, on the contrary, is the evidence of debility, and 178 STUDY OF DIAGNOSIS. 1 at once suggests the necessity of care in the conserva- tion of life, and the employment of means which will give strength, especially the selection of proper foods. A cough may be feeble from deficient spinal innerva- tion, and spinal stimulants would prove the best reme- dies. Coughs are spoken of as short, hacking, deep, bron- chial, etc., and these characteristics may suggest the locality of disease. A short cough may arise from dis- ease of the upper lobes of the lungs, or it may be due to disease of the parenchyma of the lung, as in the first stage of a pneumonia. The hacking cough evi- dences irritation of the respiratory nerves pointing. in the throat. The deep or bronchial cough is at once referred to lesions of the bronchial tubes, though it is not as good evidence as we would wish. A cough may have its origin in irritation of any part of the respiratory apparatus, from the pharynx, larynx, trachea, bronchial tubes, parenchyma of lungs, to the pleura. As named above, its character may suggest the seat of disease, but as a rule, it is not definite. A sin- gular thing about coughs is, that the irritation points so that many times the patient can localize the sensa- tion of irritation for us. Cough very frequently points in the pharynx, and the irritation of the throat seems to be its direct cause; such a cough is based to a con- siderable extent upon irritation of the respiratory nerves, and remedies directed to relieve this will be the best cough medicines. In other cases cough points about the supra-sternal notch, and if very severe and persistent suggests the use of remedies which influence the sympathetic nervous system, as Veratrum, Bryonia, Cactus, Pulsatilla. STUDY OF DIAGNOSIS. 179 Coughs may be spasmodic and paroxysmal, even in severe cases, showing distinct, epileptiform symptoms. Whooping cough is the typical spasmodic cough, but we have in the cough of measles, and some diseases of the respiratory apparatus, the same characteristics. It suggests Drosera, Belladonna, and Bromide of Ammo- nium. PHYSICAL DIAGNOSIS. Diseases of the respiratory organs and the heart are diagnosed in part by an exploration of the chest with the ear. Whilst an examination of the chest with the eye and the touch will determine something of the character of disease, and direct our attention to reme- dies, our reliance will be placed principally upon what we hear. In the case of the respiratory organs, a very import- ant part is to determine the capacity of the lung for air, or the amount of air contained in the chest, and this is accomplished by percussion. The walls of the chest are thin and elastic, whilst the lung which fills it contains normally four or five times as much air as there is of solid substance. Any elastic body contain- ing air will give resonance when struck, and the reso- nance will be in proportion to the amount of air. Lessen the amount of air, replacing it with a solid or fluid, and dullness of sound is the result. The object of percussion then, in diseases of the re- spiratory organs, is to determine the condition of the parenchyma of the lungs with reference to capacity for air. By examination of the healthy thorax we obtain a standard of normal resonance for different parts of { 180 STUDY OF DIAGNOSIS. : the chest, and this we use as a basis for comparison. In many cases, but one side of the thorax being in- volved in disease, a comparison is instituted between the sound and the diseased side. In such cases, of course the information is more accurate, as we have the normal standard of resonance before us. Percussion is either direct or mediate, as we strike directly upon the wall of the chest, or interpose some- thing between. Direct percussion may sometimes be employed with advantage, using one or two fingers to give the blow. The only objection to this method is the unpleasantness to the patient, and the difficulty of making percussion of the intercostal spaces. In medi- ate percussion an ivory or rubber plate (pleximeter) is sometimes employed, using the finger for the stroke, or a small mallet of similar materials. The best method, however, is to apply one or two fingers accurately to the wall of the chest, and use the middle finger, sup- ported by the ring finger and thumb to give the stroke. It is necessary to use care in this, the fingers of the one hand being accurately applied to the chest, and the stroke being at right angles, and the muscles of the hand held firmly so as to give a quick rebound. As the object to be determined is the capacity of the lung for air, we make percussion both during full in- spiration and after expiration. In examining the mar gin of the lungs over the false ribs and the sternum, it is necessary to have the patient take a full inspiration to carry the lung down to the insertion of the diaphragm in the one case, and to the mesial line in the other. In making percussion over muscles it is well to put the body in such position that the muscles will be rendered tense. In examinations about the shoulder, it is raised STUDY OF DIAGNOSIS. 181 to allow our examinations to be carried up in the axillary space, or thrown forward or backward, to enable us to reach the upper part of the chest. In making comparison between the two sides, we are careful that there is the same degree of inflation, and it is better to have the patient take a full breath, and hold it as long as he can conveniently, or cease respiration for a moment, after the air is thrown out. Normal resonance tells us that the parenchyma of the lung is free from effusion, it may be the seat of irri- tation, but the capacity for air is not interfered with. Increased resonance in slight degree is heard when the function of one lung being impaired, the other does an increased work. In greater degree it is the evidence of emphysema. When very marked, and over a lim- ited portion, it is the evidence of a cavity. • Dullness on percussion evidences that the air is re- placed by a solid or fluid; as is the degree of dullness, so is this change in the physical condition of the lung. We have dullness in acute pneumonia commencing about the third day, sometimes earlier, and increasing as deposit takes place in the air cells and intercellular passages, and in the connective tissue-as is the dull- ness, so is the intensity of the disease. Resonance returns when the circulation is restored, and effused materials are absorbed. Dullness is also an evidence of chronic inflammation of the lungs, being usually much more extensive than in phthisis pulmonalis, for which it might be mistaken. Dullness on percussion is heard in phthisis, when the tubercle is deposited in consider- able quantity and near the surface. In the earlier stages the dullness is so slight that it is not an import- aut evidence of disease. 182 STUDY OF DIAGNOSIS. We have dullness on percussion where there is fluid in the pleural cavities, whether it is simply of water, or the products of inflammation. In this case the dullness is of the most dependent part, and unless it is an ex- treme case, changing the position of patient, will change the situation of the dullness. We have dullness on percussion in hydropericardium, and to a limited extent in bypertrophy of the heart. The situation of the dullness, and the change in the sounds from the heart, will determine the condition of disease. Occasionally we have dullness on percussion from the formation of a thoracic aneurism, and still more rarely from growths in the cavity of the chest. Other symp toms will determine the character of the wrong. The reader will notice that in acute disease dullness on percussion has reference mostly to effusion into, and solidification of the parenchyma of the lung. The ex- tent of the dullness determines the amount of tissue involved, and its intensity determines, to some extent, the severity of the lesion. In so far as it suggests treatment, it would say-lessen irritation and determi- nation of blood to the lungs-give the respiratory appa- ratus rest-by appropriate food, and in so far as medi- cines act to sustain the life of the part, and of the body at large-and by the establishment of secretion, promote the absorption of the effused material. Percussion is sometimes employed in other parts than the thorax to give evidence of disease Thus we find that some wrongs of the stomach, of the liver, spleen, bowels, and reproductive apparatus, give rise to changes in the sounds heard on percussion. Disease of the stomach with generation of gas, will 3 ' STUDY OF DIAGNOSIS. 183 be evidenced by marked resonance on percussion over the stomach. In some cases of chronic disease, this condition is persistent, and the continually distended stomach is pressed upwards until it occupies consider- able space, and resonance might lead us to suppose that a cavity had formed in the inferior lobe of the lung, had we not symptoms of gastric lesion, and the reso- nance extending across the epigastrium. On the right side an enlarged liver pressed upwards. encroaches upon the cavity of the chest, and gives marked dullness on percussion over the right false ribs. The evidences of wrong digestion, and the fullness at the margin of the ribs will correct the diagnosis. In distension of the bowels by gas, we get the evi- dence of resonance on percussion. If of the small in- testine it occupies the anterior part of the abdomen; if of the large intestine it is lateral, or in the situation of the transverse colon. In ascites the small intestine distended with gas floats at the top, and though we get the dullness of water below, and succussion on palpation, there is resonance at the highest part, if the convolutions are free to move. In ovarian dropsy, on the contrary, the sac displaces the small intestine as it grows, and either crowds it upward or backward. Intestinal resonance on the surface, in dropsy, is therefore one of the differential points in distinguishing between ovarian disease and ascites. • We employ palpation to determine the presence of fluid, whether in the cavities, or formed by the break- ing down of tissue. In some cases the evidence of fluctuation is very distinct, the wave of fluid passing 184 STUDY OF DIAGNOSIS. } distinctly from the hand on the one side, to the hand on the other. In other cases, we only obtain a sense of mobility and the elasticity of fluid. When parts give rise to sound in the performance of their functions, the character of this becomes evidence of disease. This is the case with the respiratory appa- ratus, the heart, and to a less extent with some other parts. Listening to sounds thus produced is called auscultas tion, and as practiced may be either direct or mediate. In direct auscultation, the car is applied to the part, and the sounds heard. In mediate auscultation, an instrument called a stethoscope is employed as a con- ductor of sound. I prefer direct auscultation, as we desire to hear the exact sounds produced, neither intensified nor modified. It is quite as easy to apply the ear as a stethoscope, and except in some rare cases of cutaneous disease there is nothing objectionable in such examination. It is claimed that female modesty might be shocked by this direct examination, both of the chest, and especially of the lower abdomen to detect the beatings of the foetal heart. But I confess that in my professional life I have met with but little of this mock modesty. The special value of the stethoscope is the impression it makes upon the public. In the olden time the phy- sician carried a gold or ivory headed cane, or rather a staff, to give him an appearance of dignity, and the professional pose, as shown by Hogarth, with the head of the cane pressed against the nose or forehead, in profound thought, is a fair representation of the dig- nity "that pays." As the physician's cane has gone out of fashion, the stethoscope, and instruments of ง STUDY OF DIAGNOSIS. 185 similar kind came in to sustain the dignity of the pro- fession. Stethoscopes are made in varied forms, from the sim- ple short wooden cylinder (with a hole through it) to the double ear-tube instrument of Camman. Some are so illy adapted to their use, that scarcely anything can be heard, except the unpleasant roaring from ill adap- tation to the ear. The best stethoscope is a simple cylinder of solid wood, with the one end adapted to the walls of the chest, and the other to the physician's ear. It may be long or short, or have any shape the taste of the maker may give it, if it possess the characters named, it will answer its purpose well. In the practice of auscultation, whether direct or with a stethoscope, the physician is careful to avoid adventitious sounds, and to place his body in a conve- nient position for listening. The rubbing of clothing, either upon itself, or against a stethoscope, will fre- quently mask the sounds we wish to hear. A con- strained position of body frequently interferes with listening. In auscultation of the chest in health two respiratory sounds are heard-the respiratory murmur, and the bronchial sound. The first is heard during inspiration. and expiration over the entire surface of lung; the second is heard by applying the ear over the spinal column from the middle cervical region to the sixth dorsal vertebra-the spinal column being a good con- ductor of sound. If the normal respiratory murmur is heard we know this portion of the parenchyma of lung is healthy; if it is changed in character, or re- placed by adventitious sounds from the air cells and small passages, we know that there is disease. 186 STUDY OF DIAGNOSIS. In studying auscultation, it is well to study in the language most familiar to us. If we are original Romans we may pursue the study in Latin; if French, we may use French technical terms; but if English is our mother tongue, we had better employ English, and use words with especial reference to their meaning. I' think it is possible to so classify and name the morbid sounds that the reader can learn them without trouble. We may say first, that a wrong sound made in the respiratory apparatus is evidence of disease of this apparatus. We want then to determine the value of the sound, and the distinct lesion that produces it. To this end, the first question is as regards the medium for the conduction of sound. Solids conduct sound best, fluids next best. Air stands next as a con- ductor, and mixed bodies last. The lung, with its spongy tissue filled with air is a bad conductor of sound. If it is solidified, it becomes a good conductor, and sounds will be heard, which otherwise would not reach the ear. Fluids compressing the lung are also good conductors of sound. To determine this point, then, percussion is made-if there is resonance the sound is referred wholly to a wrong of the part where it is produced; if there is dullness on percussion, it is referred in considerable part to the consolidation of lung, or to the effusion, which gives a better conductor of sound. Morbid sounds may be divided first into blowing and crepitant, having reference to the parts in which they are produced. Blowing sounds are produced in bron- chial tubes, and crepitant sounds in the intercellular passages and air cells. Blowing sounds are blowing. The idea the listener 1 STUDY OF DIAGNOSIS. 187 gets is of air blown through a tube possessing some clasticity. In the blowing sounds heard in diseases of the respiratory apparatus, the listener gets an idea of obstruction; the air does not pass as freely as in health. In one case the sense is of constriction-evidently the calibre of the tube has been diminished-the sound has the higher tone or shrillness that would be thus pro- duced. In another case the obstruction is evidently within the tube, either from fullness of mucous mem- brane, or from increased secretion, and the sounds are lower in tone-duller-or show the evidence of mucus in more or less of gurgling. In a third class of cases, the obstruction is evidently from want of elasticity and tone in the tube, which yields before the passage of air, both in inspiration and expiration-the wavering tone of the sound determines this condition. In so far then as we have analyzed the simple char- acter blowing, we have suggested to us a rational prac- tice of medicine. Contraction of bronchial tubes is in the majority of cases from irritation-employ those remedies which take away the irritation. Fullness of mucous membrane suggests the use of means to relieve determination of blood, and to promote absorption Increased secretion suggests the employment of means to take away irritation and determination of blood, and check secretion. Whilst the wavering sound indicating atony, calls for stimulants, tonics and restoratives. Blowing sounds are dry and moist, and these common. words express clearly the idea formed upon hearing the sounds. They are dry and moist, as they refer to a condition of dryness or moisture of the mucous lining of the bronchial tubes. Dry blowing sounds evidence a condition of bronchial : 188 STUDY OF DIAGNOSIS. 1 tubes in which there is an impediment to the free passage of air, and more or less arrest of the normal mucous secrction. Dryness itself is an impediment to the passage of air, but in addition there is contraction of the bronchial tubes. We are in the habit of saying— as is the blowing, so is the contraction of the tubes- as is the sound of dryness, so is the arrest of secretion. Contraction of bronchial tubes results from irritation, and it suggests that such means be employed as will relieve irritation. Dryness results from irritation, de- termination of blood, and the developed inflammatory process. Given a dry blowing sound, we at once think of general and local sedatives which lessen determina- tion of blood, remedics which allay irritation, remedies which so rectify general lesions of circulation and tem- perature as to permit secretion, and remedies which restore secretion, if such be necessary. Thinking in straight lines, our ear gives us information of the con- dition of the air passages, we at once think of the pathological states, and having the factors of disease before us, we at once think of those remedies which restore normal functional activities. Moist blowing sounds tell us of obstruction to the free passage of air, and to the pressure of fluid in the air passages. As is the blowing so is the impediment to the passage of air; as is the moisture, rattling, bub bling, gurgling, so is the amount of fluid in these pas- sages. The ear readily determines from the character of the sound, whether the blowing is still due to contraction of the tubes, for in this case the sound is steadier and more resonant, than if caused by obstruction from accu- mulated fluids, or from atony. The well-sustained, :. STUDY OF DIAGNOSIS. 189 sonorous sound always means contraction-contraction results from irritation-use remedies to lessen or take the irritation away. The impediment from secretion of mucus, muco-pus, or purulent fluid is clearly expressed in the sounds heard, and it is well to take the evidence of the ear, rather than any technical classification of sound. The presence of just sufficient secretion to lubricate the passages, of occasional accumulations which need re- moval by expectoration, of continued accumulation, giving rise to rattling sounds like the bursting of large bubbles, or the gurgling which comes from large quan- tities of fluid, are distinct and unmistakable. The treatment is clear-take away the causes of determina- tion of blood, whether due to irritation of the respira- tory nerves, or some general lesion. Give these tissues such support as we can, by the use of remedies that give local or general stimulus and tone. And to a cer- tain extent favor the removal of these accumulations by expectoration-usually by giving strength to the respiratory apparatus. The evidence of atony of the respiratory passages is found in the yielding or tremulous character of the sound. Whilst the evidence of contraction was found in the well sustained sound, this is found in the feebly sustained sound. The treatment is clear-to sustain and increase the strength of the patient, and to stimu- late and strengthen this enfeebled organism. In some cases alcoholic stimulants give prompt relief, and their effect is maintained by Quinine, restoratives, and food. The local remedy is Lobelia in stimulant doses, and we always think of this, especially in infancy and child- hood. i 190 STUDY OF DIAGNOSIS. When cavities are formed in the lung, communicating with a bronchial tube, the ear detects a peculiar blow- ing sound, as of air blown into a bottle. This may be dull and more or less gurgling, showing that the pro- cess of removal is not yet completed, and the walls of the cavity are of the spongy, partly broken down lung. Or it may be clear, well sustained. and more or less re- sonant, showing the removal of deposit, and cicatriza- tion. Smali blowing sounds, varying in character, shrill, whistling, piping, irregular, tortuous, dry, moist, rat- tling, all combined, in varying proportions, are the best evidences of phthisis pulmonalis. If the reader will think for a moment of the structures involved, the situation of the tubercular deposits, how they must press upon the smaller bronchial tubes, changing their position, making them tortuous, changing their calibre, he will see at once that these are just such sounds as might be expected. In addition to these small, queer, blowing sounds, the ear detects that known as dry crackling. During a full inspiration three or four distinct crackling sounds are heard, which seem to the ear very much like the sounds produced by separating two surfaces attached by a glu- tinous fluid. And undoubtedly this is the condition, for if the tubercle is so deposited as by pressure against a bronchial tube to efface its cavity, the separation of the glutinous walls of mucous membrane would give just such sound. Crepitant sounds take the place of the respiratory murmur, and are formed in the air-cells, the intercel- lular passages, and the minute bronchial tubes. When, therefore, small crepitation is heard, we refer it at once STUDY OF DIAGNOSIS. 191 to disease of the parenchyma of the lung. If we in- quire into the condition of the lung-the changes of structure that will produce such sound-we find it in irritation, determination of blood, and slight effusion into these minute air passages. If the effusion goes on, the lung is rendered impermeable to air, and the crepi- tant sound ceases. Crepitance is therefore the evidence of inflammation of the lung in its first stage, and is associated with re- sonance on percussion, for the disease has not pro- gressed to hepatization. Where effusion has taken. place to the extent of giving dullness on percussion, the crepitant sounds are replaced by blowing sounds. from the bronchial tubes, the lung being now a better conductor of sound. Larger crepitance refers us to the minute bronchial tubes, and is the evidence of capillary bronchitis. The smaller crepitance is not only heard in the first stage of an inflammation of the lungs, but returns with the absorption of the effused material, and resolution, and is therefore the evidence. of the subsidence of the disease. As crepitance is the evidence of the active stage of an inflammation, in which irritation and determination of blood are the prominent factors, the treatment is plain. In so far as we can take away the irritation, and stop the determination of blood, our treatment will be rational. The frequent pulse, the high temper- ature, and the rapid respiration, are important elements in the furtherance of the local disease, and means which will rectify these wrongs, are of first importance. As the succeeding stage is one of local depression of life, no means should be employed that will depress either the life in general, or of the affected part. 192 STUDY OF DIAGNOSIS. Where solidification of a lung has taken place, it becomes a better conductor of sound, and if now the ear is applied and the patient is engaged in conversa- tion, the voice seems to come out through the chest. We do not get articulate speech, but simply the modu lations of the voice. This is called bronchophony (speaking through the bronchial tubes), but its only value is to determine solidification of the lung, and per- cussion is the better evidence. If there is fluid in the chest, and the ear is applied over it, the patient conversing, the voice seems to come out through the chest, but has a tremulous tone. This has been called ægophony, and is one of the evidences. of fluid in the pleural cavities. If the ear is applied over a cavity, which is free and communicates with a bronchial tube, and the patient is engaged in conversation, the articulate voice comes to our ear through the chest. This is called pectoriloquy, and is additional evidence of the formation of a cavity in the lungs. In some cases of structural disease of the pleura, the result of inflammation, certain friction sounds are heard, but they are not very common, distinct, or defi- nite. Once in a while they are said to assume the dis- tinctness of the "creaking of new leather," but in the two cases I have seen, the sounds were evidently from wrong of the parenchyma of the lung, and not from the change of the pleura. We employ auscultation in the examination of the heart with as much advantage as in diseases of the respiratory apparatus. As the sounds produced by the heart are much louder, and more distinct or arbitrary, many persons will succeed better in auscultation of the heart, than of the lungs. STUDY OF DIAGNOSIS. 193 sensation. 'The normal sounds of the heart are smooth, uniform in tone, regular in time, and give the ear an agreeable. No description in words would give the reader a sufficient knowledge of them; they must be heard to be thoroughly known. It is hardly worth while to call the reader's attention again to the impor- tance of knowing the phenomena of life for himself, and especially with regard to things that may so easily be known by the senses. If, in examination of the heart, we find that the sounds are normal, we are quite sure that there is not structural disease of this organ. If there are general symptoms of heart disease, the wrong is functional. If, on the contrary, the sounds of the heart are changed, or replaced by adventitious sounds, we are just as sure that there is structural disease of the organ. The two exceptions to these rules are:-1st, in case of anæmia or spanæmia, we hear blowing sounds, which are re- ferred to the wrong of the blood, and not to the heart; and 2d, in fatty degeneration, no change in the sounds. of the heart announce the structural lesion. The morbid sounds of the heart may be divided into blowing and sawing, and the ideas conveyed by these words represent exactly the character of the sound. Whilst blowing sounds may be referred sometimes to lesions of the walls of the heart, and a wrong in mus cular contraction, the sawing sounds are referred to the openings of the heart, and to the valves, and usually to lesions that obstruct the free flow of blood. The blowing sounds have been named bellows mur- murs, and have every range between the simple, smooth, blowing sound, similar to that heard from the bronchial tubes, to the roughened, irregular, rattling 17 194 STUDY OF DIAGNOSIS. sound, similar to that produced by a pair of bellows in motion. If the sound is dependent upon poor blood, it may many times be heard over the larger arteries as well as the heart, and in this case will call for the proper restoratives and food to make good blood. If dependent upon enfeebled nutrition, or degeneration of the walls of the heart, we employ means to give the heart rest, see that it is not subject to excitement, and employ means to improve nutrition. The rough, irregular sound that is attributed to valvular insuffi- ciency and regurgitation, would demand the same treatment. The saw sound has been divided into three varieties, the saw, rasp and file sounds, but the distinction has but little reference to conditions of disease, or to the use of remedies. Possibly the finer sounds may refer us to a more acute condition of disease, in which plastic material is yet being deposited. In some cases of val- vular insufficiency we hear a marked saw sound, but it has an irregularity and dullness that we do not meet with in the other cases. The more common lesions that give rise to contrac- tion of the openings of the heart, and such disease of the valves as prevent their free movement, are inflam- matory, and give fibrinous exudation as the result. The most of these are rheumatic in character, involving the tendinous portions of the muscle, and the endo- cardium. There are rare cases in which the sounds are due to fibrinous vegetations from the valves, or to ossific deposit in their structure. The treatment suggested by these sounds has refer ence, first to rest, and secondly, to means which will promote absorption, and give us a better renewal of STUDY OF DIAGNOSIS. 195 life. Rest is absolutely essential to recovery from chronic inflammation and the absorption of its pro- ducts. We want physical rest, and mental rest, and such relief from irritation of the cardiac nerves as may be obtained from the use of Cactus, Pulsatilla, and tho special sedatives. Removal of deposits is facilitated by the establishment of free secretion, and a better heart is made by means to obtain good blood, and good nutrition. To determine pregnancy after the fifth month the ear is applied over the lower abdomen to hear the beat- ings of the fœtal heart. If it is heard the diagnosis is clear, but if not, we are not yet certain that pregnancy does not exist, for in many cases, from feebleness of the movement of the foetal heart, excess of liquor amnii. thick abdominal walls, or the position of the child, it can not be heard until late in pregnancy, or not at all. DIAGNOSIS BY THE SENSE OF SMELL. as some The sense of smell has less development in the majority of men than any other of the senses- writer has recently remarked-" it is yet in the savage state." It may not be of much use in diagnosis, and yet the little it may tell us we want to know. It requires education, as do the others, and we must learn to dis- tinguish pleasant odors from stinks, and thus be able to analyze stinks, and determine their influence upon the human body. It is possible that some. persons will never be able to recognize the genus "stink," much less be able to assort them for our present purpose. It is well for the physician to commence educating 196 STUDY OF DIAGNOSIS. his nose at home, and to start with a realization of the fact that all unpleasant smells are noxious to the human body. It requires very little exercise of reason to reach this conclusion, for if the thing was not unplea- sant or noxious to the economy, the nose would not give the warning of unpleasantness. What is the evi- dence of disease to the person suffering? Unpleasantness; the very expression used, "persons suffering," tells the story of disease. Is disease ever pleasant? No. Are causes of disease ever pleasant? No. Do causes of disease ever pleasantly impress the senses? You might answer yes, but I say no again. Commencing at home I put my nose inside your office door, and-heaven preserve me-what a com- pound of stinks, from Asafoetida to Jalap, from Castor Oil to Turpentine. Lesson No. 1, true remedies have no bad odor, clean up your stinks and put them in the nearest privy-vault, and have a thorough disinfection. Reason why-it will be money in your purse--people that pay good bills don't like stinks, as a rule. Let me nose your saddle-bags and pocket-case? Faugh! what a terrible sickly smell!-reminds me of the old country doctor, who was always announced by a mixed smell of Asafœtida and Jalap. It won't do in this age; burn them up, and order a new stock. Now clean up your- self, and get your nose in good working order, that you may learn diagnosis with it. Do you know how to eat onions and go-a-sparking too? Have the maiden taste them. Reverse the simile-if you carry bad smells about you, you will not be able to detect them in the sick room-and it is a most important work, believe me. When I visit a sick room, my nose commences the inquiry, (it is a most excellent interrogation point), STUDY OF DIAGNOSIS. 197 What provisions have you made for fresh air, sunlight, and cleanliness? It says straightway, the air is bad, there must be ventilation, and opens a window, builds an open fire, and does what is necessary. It noses a stink from under the bed, and suggests half cleaned chamber utensils, excreta, dirty clothes, dirtied floors, etc. It says with emphasis there must be a thorougn cleaning up. The excretions must be removed as soo~ as voided, the utensils thoroughly cleansed and disin fected, every loose thing removed, the floor cleansed the bed drawn from the wall, and so arranged that the air can pass freely under it. It says you have been trying to feed this. patient upon stale, badly prepared food, and it detects it remaining in the room hour after hour, poisoning the atmosphere, and taking away what little desire the patient may have for nourishment. It says, the food for the sick must be nicely prepared, fresh and savory, at such times as he can best take it, and then promptly removed from sight or sense. It says—you are dirty-dirty in person, dirty in clothing, dirty in bed. You must be thoroughly cleaned up, washed with soap and water, have frequent changes of clothing and bed linen-"“ cleanliness is next to godli- ness." You can't hide dirty sheets from this nose, or a bed soiled by involuntary discharges, or a bed sore, a badly dressed wound, however you may try to cover them up. It recognizes the row of nasty medicine bottles, and says, "take them out" - your spoiled poultices. and fomentations, and says, "fresh water." It tells you of damp walls, of lack of sunshine, of choked drains, of ground saturated with garbage, of foul closets, of cellars uncleaned, of decomposing vegetables, 198 STUDY OF DIAGNOSIS. and of the hundred and one noxious agencies which breed disease and steal away a man's life. But it not only tells you of dirt, and specifies clean- liness as the remedy, but it tells of specific agents to destroy causes of disease. I will warrant that you have already associated an unpleasant odor of decay with lime. Lime to freshen the air of cellar, lime to slush a bad drain or cess-pool, lime to make way for sunlight, and to get rid of the dead air of a house. You will recognize a sweetish, mawkish, unpleasant- odor, similar to that exhaled from smallpox, and it says Sulphurous Acid, as plainly as it can be expressed. You burn Sulphur in the room, or in the whole house, and you are surprised how it changes the air, and how much the patient is benefited by it. In other like cases you sprinkle the floors with Sulphurous Acid, wash the chamber utensils with it, and the dressings in surgical disease. It is not simply to get rid of a bad smell that we do this, but it is to remove a cause of disease. There are other cases in which a peculiar putres- cence reminds you that Chlorine, Carbolic Acid, or Iodine are required. You employ Labaraque's disin- fecting solution, or Chloride of Lime, and you see a decided improvement. Or you use a solution of Car- bolic Acid, especially as a wash to things which are soiled, to wash dressings, or as an application to wounds, and there is a change for the better. There is a bad odor that simulates the offensive sputa of chronic bronchitis, and some cases of phthisis, which would at once suggest Iodine, and we use it as a disin- fectant, a dressing, a local application, or as an'inha- lation. So too there is an unpleasant odor, peculiar to phlegmonous erysipelas, that says Permanganate of 1 Γ STUDY OF DIAGNOSIS. ၁ ဝ 199 Potash so plainly that no one can mistake the remedy. I do not wish to place too much stress upon the evi- dence of this sense, for as stated in the beginning it is but rudimentary, yet some things it does tell us with. certainty. A sweetish or mawkish odor from the breath wants Sulphurous Acid, or Sulphite of Soda. An odor resembling an offensive lochial discharge, is the best evidence of the want of Chlorate of Potash. The hot breath, with unpleasant pungence, as of Am- monia, calls for Muriatic Acid. The fetor resembling that from cynanche maligna, calls for Baptisia. But whether we can distinguish one bad smell from another or not, we know one thing, that they demand cleanliness, good ventilation, and a restorative treat- ment. Going one step further, they evidence the con- dition of sepsis or zymosis, and demand that we select the proper antiseptic. If we can select it from the odor, good; if not, and in any case, we have other ex- pressions of disease that will point out the particular remedy required. If we apply the sense of smell to the excreta we find it of some value, though possibly not of very much. The cutaneous excretion gives a distinctive odor, and in disease we sometimes find marked changes in this. It is not difficult to recognize the pleasant odor from the healthy skin, kept clean, as it is not to recognize the odor of the person kept dirty. In treating children the evidence of our nose is frequently opposed to the evidence of our eyes. The child seems clean, but the unpleasant odors tell you to look beneath the surface, and it is dirty. We find all manner of odors from the person, running the range of" from grave to gay," and they tell the story of disease and vitiated secretion. : 200 STUDY OF DIAGNOSIS. Some of these are so characteristic that they can not be mistaken, as for instance, the peculiar urinous smell in tinea capitis. The urine has a distinctive odor, that may be called healthy. It may lose odor, or it may have a wide range of morbid smells, each of which should have a distinct meaning in the diagnosis of disease. If a Septimius Pease were to study uriscopy, he would probably trust his nose in preference to his eyes. The seminal odor is so distinctive that it can hardly be mistaken, and as it is very persistent, and may per- vade the entire person, it will sometimes give impor- tant information. So too is the odor from the sexual. organs of both male and female, in certain cases of disease. The fetor of the fæces is peculiarly unpleasant, yet the odors are distinctive, and would suggest health in one case, and disease in another. I have no penchant for the olden-time examination of fæces, yet even here I would about as soon trust my nose as my eyes. Pos- sibly the characteristic stinks, already named, will be found here, and the same class of remedies indicated. INFORMATION FROM PATIENT AND NURSE. We neglect no source of information with reference to the origin, condition, or progress of disease, and whilst careful not to be guided by information from nurse, friends and patient, we wish to give it its true value. Attention has already been called to the many sources of error. To a want of knowledge and care in observation on the part of nurse and friends, as wel' STUDY OF DIAGNOSIS. 201 t as their prejudices and tendency to distortion. To the want of knowledge upon the part of the patient, want of language for description, and the impairment of his powers of sensation and reason from disease. The elements of uncertainty are thus very great, and we have to pursue our inquiries with much care. Questions should never be suggestive, but should be so put as to let nurse or patient tell what they know, or to require but the simple and direct answer, yes or no. Careful attention to these points, and a continued guard upon the tongue, will soon form a habit of examination, that will lessen the danger of erroneous information. We prefer to get information from attendants with regard to the general condition of the sick, and the performance of the essential functions of life. From the patient we desire to know his sensations, as these are changed by disease. A first examination may take the following course: How long sick? What are the seeming causes of the sickness? How did it commence? What has been noticed with reference to the progress of disease up to the present time? How does the patient rest in the daytime? at night? What food and drink does he take? How often does he have a motion of the bowels? How does he pass urine? These questions may seem sug- gestive, and once in a while they may take a simpler form as does he sleep? does he eat? does he drink? It is most absurd for the attendant to attempt a de- scription of the sensations of the sick, and yet they almost always volunteer to do it. Many times they will be continuously making suggestions to the patient, and lead him into erroneous statements. They will probably have formed some theory of the disease, and 202. STUDY OF DIAGNOSIS. 1 will bend everything to the support of their theory. Physicians are very frequently guilty of this, and should try to get rid of the bad habit which they con- demn in nurses. The question-how do you feel? elicits a loose, wan- dering description of the patient's sensations, and is only important, in that it suggests special questions and examinations. The question-where do you feel bad? is pertinent, and will elicit valuable information of local disease. It does not do to take it for granted that the patient's anatomical or physiological knowl- edge is perfect, and that his reference to heart, lungs, stomach, liver, etc., means heart, lungs, stomach, liver. The direction at once follows-put your hand on the place. It is a little singular to find after a patient has located a disease in his own mind, the hand meanders about with uncertainty, trying to find its location. If the unpleasantness is marked, and means local disease, the patient has no difficulty in placing his hand upon the exact spot. If there is anything uncertain in the patient's man- ner or method, and especially if uneducated, we wish him to describe his sensations, with the hand upon the affected part In many cases we will find that the de- scription commences to wander as soon as the hand is removed. There is a reason for this; with the hand upon the part, the mind is directed to it and concen- trated, extraneous ideas are rejected, and the descrip- tion is of actual sensations. We want to know the character of the pain, its dura- tion, exacerbations and remissions, periods of recur. rence, and its influence on function. In this examina- tion the physician should show by his questions and manner that he wants concise and specific answers. } STUDY OF DIAGNOSIS. 203 The subject of pain is a study of itself, and much ess is known of it than we would wish. In some cases it indicates the special remedy which will cure, in others it simply points to a pathological condition, and remedies must be selected by other symptoms. Thus if we have a pain in the head, heavy, tense, and sleepy, we give Belladonna; if it is sharp and restless, Gelseminum; if sharp, limited in location, de- spondent, Pulsatilla. If of the frontal region and orbits, with burning, Rhus; if of the right side passing from before backwards, Bryonia; if of the back of the head, dull and heavy, Iron. The pain in right hypochondrium, pointing to the umbilicus, indeed, all pains pointing at the umbilicus, Nux Vomica. Pains deep in the ischiatic notches, Podophyllin. Pains that are tensive and paroxysmal, Macrotys. The pain of Macrotys is a singular one. It feels as if dependent upon tension, and is decidedly remittent- a continued succession of tensive pains. We usually prescribe Macrotys for muscular pain, no matter what its character, and hit it in a large majority of cases. For this remittent tensive pain-waves of pain-no matter where it is, we may prescribe the Macrotys with certainty, (the pain is not throbbing.) A recent caso of facial neuralgia was very striking. The gentleman had suffered for some weeks, and had taken various remedies without relief; and I had made three failures myself. Close questioning brought out the character of the pain, and Macrotys gave prompt relief. I admit that it is very much easier to prescribe from the location of the pain, than from its character, for whilst a patient may be able to locate it correctly, it is not possible for him to describe its character. : 204 STUDY OF DIAGNOSIS. ! - If we take the pain of Lobelia, we will find its pri cipal characteristic anguish, of which angina pectoris and neuralgia of the heart offer the most common ex- amples. It is that indescribable sensation as if the life was being forcibly riven from the part-anguish ex- presses it. Lobelia is specific to it. Give twenty to forty drops of a good tincture of the seed to a person suffering from angina, and there is instant relief, which becomes complete in a short time. I have seen one case of uterine neuralgia presenting this character, and from which the patient had suffered beyond conception —a single dose arrested the paroxysm; and its repeti- tion when the symptoms were felt, gave a radical cure. I have seen two cases of abdominal pain presenting this character to some extent, and both were relieved by Lobelia. A singular case of hypochondria, in which the feeling as if a movement of the body would endan ger life, but without pain, was cured with Lobelia. The peculiarity of this pain or sensation is so dis- tinct, that patients may describe it. For many years (indeed it was one of the first things I learned´in prac- tice) I have given Lobelia in certain cases of labor where the pains assumed this character. Every one will have recognized the two classes of pain, one of which is well borne, which is really relieved by the action of the will, and the other which finds no such antagonism. In the latter class I find the indication for Lobelia, and it has proven one of the most efficient agents I have ever used in obstetric practice. Of the two agents Ergot and Lobelia, I would take the last a hundred to one. Let me briefly call attention to the abdominal pain of Nux Vomica. ; STUDY OF DIAGNOSIS. 205 I say it is any pain having a tendency to point at the umbilicus; it is pretty accurately located. It may be a simple colic, a bilious colic, a derangement of the func- tion of the liver, a wrong of the spleen, a dysmenor- rhoea, a disease of the colon, irritation of the bladder- if the pain shows the constant tendency to the umbili- cus-I should give Nux. I should fail sometimes, but the failures would be small in proportion to the suc- cesses. The definiteness of the symptom, and its easy recognition, are what please me. The pain indicating Rhus Toxicodendron is very dis- tinctive. Frontal pain, especially involving the orbits, and inclined to be more severe on the left side. Such pain would lead me to prescribe Rhus, if there were no other indications. Add the peculiar appearance of the papillæ at the end of the tongue, and I would have a positive assurance of success. To any pain add burning and we would think of Rhus as a possible remedy. Given, the pains of rheumatism with burning, and Rhus is the anti-rheumatic, or is alternated with Macrotys. A case of puerperal fever this Summer in which burning sensations and pains were pronounced, was cured with Aconite and Rhus; and arrested so promptly that there could be no mistake in the action of the remedy. The pain calling for Bryonia, whilst it may be sharp or dull, always has with it a sense of oppression, as if the part were enfeebled, and could not perform its function. Homœopaths speak of burning as character- istic of this pain, but I have not been able to see it. Take a case of pleurisy, or pleuro-pneumonia, or pneu- monia, with this sense of oppression and feebleness, as if the part could not and should not do its work, and Bryonia, with the proper sedatives, will prove curative. 206 STUDY OF DIAGNOSIS. In the same way a rheumatism giving the same symp- toms of inability, with increased pain following the use, will be cured with Bryonia. The pain calling for Belladonna is dull, heavy, full, with a sense of functional impairment. It makes but little difference where you find it, or in what disease; whether a simple headache, an ague, "bilious fever," or inflammation of the lungs, Belladonna will prove curative. The pain calling for Stramonium is constrictive, and when involving muscular structures, is attended with persistent contraction, and of the outlets of the body is expulsive. A case of dysentery, with most violent expulsive movement of the pelvic muscles, was speedily relieved with Stramonium; as was a case. of broncho- pneumonia, showing as a symptom a most marked and unnatural constriction of the chest. The pain calling for Gelseminum has as a marked feature exalted sensibility and arterial throbbing. In some cases, especially in the head, the patient dreads movement, and the pulsation of the arteries is distinct and painful. With such pain in any part of the body, we would prescribe Gelseminum with every assurance of success. The pain calling for Chelidonium is dull, heavy, ten- sive, with occasional twinges, as if the part was being torn. Situated in the hypochondria or 'epigastrium, Chelidonium is the "liver" medicine. The pain calling for Iodide of Ammonium seems to involve a definite amount of tissue, as in inflammation, and yet points at some particular place which might be covered with the tip of the finger. In thus calling attention to the symptomatology of STUDY OF DIAGNOSIS 207 pain in therapeutics, I do not wish to be understood a claiming that it is infallible. Our own senses are suf ficiently imperfect, even when trained by long obser vation. The senses of the patient are untrained and impaired by disease, and his descriptive powers may be very feeble. NOSOLOGY. A distinct department which has for its object the classification of diseases, is named nosology, and though we do not propose to make such classification, the sub- jeet demands a brief study. In so far as the ordinary classification facilitates study, and the knowledge of disease, it will prove beneficial, but whenever it is made the basis of therapeutics, it must work an injury. Nosology is said to have three objects of considera- tion 1st. The distinction and definition of particular diseases. 2d. The nomenclature of the diseases, or the assignment of the names by which they are to be des- ignated, so that each disease may be distinguished and known by an appropriate name. 3d. The arrangement or classification of diseases in some methodical and con- venient order by which they may be distributed into classes, orders, genera, or species." We employ this method in natural history, and divide animals and vegetables into "classes, orders, genera, or species;" why should we not employ it in the study of disease? If one will think for a moment the reason will be obvious. The individual, animal, or vegetable, is a distinct, tangible entity; disease is a method of life. When we use this classification; we 208 STUDY OF DIAGNOSIS. } think of the object as things, not conditions or states. Thus this method of classifying disease carries to the mind the idea of disease as an entity, a thing that has precise form and condition. This idea has been the foundation of an erroneous practice, and the obstacle to a successful study of medicine. The reader will understand me to say that so far as therapeutics, or the giving of remedies for disease is concerned, the common nosology is a continued source of error, though in so far as it may facilitate the study of pathology it may answer a good purpose. Used to direct the means of cure, it is wholly insufficient, and are many times erroneous. Under single names grouped the most diverse characters of disease, varying in different persons and at different times. If disease is an entity, the doctor thinks of his medi- cine as a policeman who takes that entity by the collar and walks it out of the body. Why not? "Worms" is a disease, then ascaris lumbricoides, a variety of this disease-send in Mucuna Pruriens to tickle the disease to death and make it "vamose the ranche." Or, we might arrange it as follows: Class- eccritica; genus-malis; species-pediculis capitis; treat- ment-crack them. It does look a little funny when we take this view of it, and yet you may say that this is an exceptional case; let us sce. Discase erysipelas, grows by continuity of structure; treatment-fence it in and keep it from spreading And so the doctor takes Nitrate of Silver, Tincture of Iodine, or Tincture of Muriate of Iron, and makes his dark line on the outside of the disease, saying, here is an obstruction, I want you to stay on your own side. If the erysipelas had been a vicious STUDY OF DIAGNOSIS. 209 1 animal, he could not have built his fence with a more determined purpose. If the reader will think for a moment, he will be surprised how strong a hold this idea of disease as an entity has upon the profession, and how it is made to serve as a basis for the most unpleasant medication. The physician forgets the life of the patient in his effort. to rid him of his disease-a disease that he has caught, or one that has caught him. He forgets the impair- ment of life, the functional wrongs; that disease is a condition of life—is life, and that it can not be vomited through the mouth, purged from the bowels, sweated from the skin, passed with the urine, drawn by a lancet from the blood vessels, killed with mercury or tartar emetic, or so afflicted by the class antiphlogistic that in sheer desperation, it will take itself out of the body. Our authority says DISTINCTION AND DEFINITION. that the first object of nosology is "the distinction and definition of particular diseases, or of their genera and species." Here is the common error, of disease as an entity, for which he wishes a distinction and definition. He does not desire a definition of pathological life or groups of unvarying pathological wrongs, but such dis- tinction as will enable him to affix a name. Neither are we to understand that this "distinction and definition" is to have reference to means of cure, or indeed that they will serve as any guide to reme- dies Aitken remarks: "In modern times the great advantages that have arisen from establishing defini- tions in natural history upon fixed and determinate principle, not only of its various objects individually, but also of the groups under which it was found pos- ì 18 210 STUDY OF DIAGNOSIS. sible to arrange them, suggested to medical men the idea that much advantage might also result to the science of medicine from defining diseases, and such groups of diseases as might be found expedient to re- cognize, under general terms or common names, based upon some fixed and determinate principles.” The reader will notice in this quotation the tendency to the error named, and the student finds it impossible to read medicine without getting the idea, that diseases thus classified must be something definite, like the animals and vegetables whose classification is appro- priated. NOMENCLATURE.-The second object of nosology is to name the diseases thus defined, and the medical world has travailed in labor with names, for many years. It is very much as recorded in Genesis: "And out of the ground the Lord God formed every beast of the field, and every fowl of the air, and brought them unto Adam, to see what he would call them; and what- soever Adam called every living creature, that was the name thereof." A name should carry to the hearer an accurate idea of the person or thing in its various attributes, and if names of diseases did this we could not object. In so far as names do indicate the wrong of life, names aro useful as guides to correct practice. In so far as names direct the mind in pathological inquiry, they will prove of advantage in medical study. But when- ever they are recognized as entities, at which remedies are to be hurled, and which must be forced out of the human body, then they will prove a source of error. Plancquet claimed that "the name of each disease STUDY OF DIAGNOSIS. 211 or species should be so significant that a person slightly acquainted with the language and the subject, should, on hearing it, immediately understand what is the nature of the disease it designates." To such a nomen- clature we should not object, and if it should go one step further, that on hearing it we should immediately understand what remedy would rectify the wrong, or cure it, then it would be perfect. If we take the nomenclature of the Royal College of Physicians, of London, we find 1,146 distinct dis- eases, and if we would add the named sub-classes or varieties it would bring the number up to near 2,000. A man has one right life, and his varied physiological processes can be studied under one or two score heads, but his wrong life requires a classification under 1,146 heads, or distinct varieties. If we examine the therapeutics which go with this classification, we find that it numbers but about one hundred remedies in use, and but about twenty in gen- eral use, and of these five to ten are in common use for everything. This shows a wonderful discrepancy between the nosology of disease and its therapeutics. CLASSIFICATION OF DISEASES. Probably more is gained in the classification of disease than in its nomen- clature. The object of classification is to notice the resemblances rather than the differences, to determine the pathological wrongs common to a series of diseases, rather than to determine the special symptomatic dif- ferences. With regard to classification, Dr. Aitken remarks: "It is obvious that any single character, or combina- tion of characters, in respect of which diseases agree F } 212 STUDY OF DIAGNOSIS. with or differ from each other, may be made the basis of methodical arrangement, under a larger or smaller number of divisions, or of higher or lower genera (language of logicians), or of classes, orders, and genera (language of naturalists). By ingenious devices of the mind the physician or the statist may classify and arrange his knowledge so as to bring it all more readily within his reach for any special purpose-so as to make it, in fact, more at his disposal-to facilitate and pave the way for further investigation. Such are the legiti- mate objects and the results of all methodical arrange- ments. Classification, therefore, being only a method of generalization, there are, of course, several classifi- cations of disease which may be used with advantage for special purposes. The physician, the pathologist, the jurist, the hospital statist, the army or navy medi- cal officer, may each legitimately classify diseases from his own point of view, and for his own purposes, in the way that he thinks the best adapted to facilitate his inquiries, and to yield him general results. The medical practitioner may found his main divisions of diseases on their treatment, as medical or surgical; the pathologist, on the nature of the morbid action or pro- duct; the anatomist or the physiologist, on the tissues and organs involved; the medical jurist on the sud- denness, slowness, violent or unnatural mode of the death; the hospital statist, on the kind of diseases which are treated in its wards; and all of these points of view may give useful and interesting results, (Farr). “There is thus no question on which more diversi- fied opinions are legitimately entertained than on that of classification. Although it is the aim of all syste matic writers and observers to arrange the objects of STUDY OF DIAGNOSIS. 213 study in the most natural order possible, and although diseases are named as if they were individual entities, yet they present so great varieties that they will not admit of that definite and, in many respects, natural species of classification which can be made with objects of natural history. Manifest reasons of convenience and facility for work can therefore be assigned as the great incentive to classification; and numerous reasons exist for classifying diseases in various ways: (1.) Men differ in their estimation of the characters on which different arrangements may be founded. (2.) The facts and phenomena of diseases on which classifica- tions may be made are not all regarded from the same point of view. Most systems are avowedly artificial, being arranged with the view to elucidate or support. a theory, or otherwise to effect a definite end. For ex- ample, by classifying diseases and recording the causes of death, the most valuable information is obtained relative to the health of the people, or of the unwhole- someness and pestilential agencies which surround them. We can take this or that disease,' says Dr. Farr, and measure not only its destructiveness, but its favorite times of visitation; we can identify its haunts and classify its victims.' We are able to trace diseases also as they perceptibly get weaker and weaker, or otherwise change their type, as some have done from time to time. We know from the valuable returns of the Registrar-General, prepared periodically by Dr. Farr, that certain diseases are decreasing, or growing less and less destructive; that certain other diseases have ceased in some measure; while other severe dis- eases have exhibited a tendency to increase. The ad- vantages, therefore, of adopting some system of classi- 6 こ ​214 STUDY OF DIAGNOSIS. fying diseases, which can be put to such useful prac. tical purposes, must be obvious to every one." If one can free the mind from the idea that nosology has a direct relation to therapeutics, these subjects may be studied to advantage. We want to learn the natural history of diseased life as we have learned the natural history of healthy life. If a classification and nomen- clature will aid in this, even if only as guide boards and mile posts, we may employ them. To a certain extent, the common nomenclature of disease is a necessity. It is quite as necessary to be able to name a disease for the satisfaction of friends, as it is to give successful treatment. The name may not probably have anything to do with the manage- ment of the case, or the selection of remedies, indeed should have nothing to do with it, yet we are forced to give a name. The first question asked of the physician in the sick room is, "What do you call it?" and we must be able to "call it" correctly according to the commonly received nosology. - If we can simplify our classification, so as to make it a good guide for study, we will do well; if we can make it suggestive of causes of disease which may be avoided, of right attention to hygiene, and an outline. of treatment, we will have accomplished all that can be reasonably anticipated. Let us see how far we can make such classification.. The first division will have reference to causes of dis- ease, as well as to pathological conditions. It will be into epidemic, contagious, endemic and sporadic diseases. The reader will notice that this is a natural classifica- tion, referring to causes of disease and their avoidance, and to a less extent to the conditions of disease and means of cure. STUDY OF DIAGNOSIS. 215 The second division will have reference to the general or local nature of the morbid states, and as will be noticed occupies the same ground as the preceding, this having reference to the conditions of disease and not to its cause. All disease may be classified under these two heads, though many times it will only have. reference to the primary lesion, for as the wrong goes on, a disease which was primarily general becomes localized, and one which was primarily local will cause general disease. A third division has reference to the structure of parts or to their functional expression, and diseases are divided into structural and functional. Again, it will be seen that this classification of disease occupies the ground of both the first and second, for all disease must be structural or functional. Here, as before, we find it especially applicable to the primary disease, for one may have commenced as a functional wrong, and grown into a structural disease, as a structural disease may have first existed, but this being cured, other func- tional lesions persist. A fourth division might be called physiological, and would have reference to the functions of the body. If, for instance, we make the usual classification in teaching the principles of medicine: Formative, Force. Heat, Electricity. Formative, Cells. Secreting, Necrological, Digestion, tissue making. does the work of secretion. pus cells. Nutrition. Blood making, Tissue making. 216 STUDY OF DIAGNOSIS. I 1 " Secretion.Excrementitious. Recrementitious, Circulation. Venous, { Arterial, Capillary. Brain, Innervation. Spinal cord, Sympathetic. Taking this classification, and assuming that there is a normal standard of health which may be known, and that disease is a departure from this standard, all lesions may be classified as being in excess, defect, or perversion. This classification is used by Dr. C. J. B. Williams in his Principles of Medicine, as in the follow- ing tables: PRIMARY ELEMENTS OF DISEASE. STRUCTURAL CONSTITUENT. ITS FUNCTION. DISEASE. STRUCTURAL DISEASE Tubular (the con- Contractile fiber. force.) Nervous Vesicular (the ductor of nerve structure generator and combiner of nerve force.) Secreting structure. Element- ary com- ponents of blood. Elementary changes in the blood. Irritability. Tonicity. Sensation. : Voluntary motion. Involuntary motion, (excited motor ac- tion.) Sympathetic action. Secretion. Red corpuscles. White corpuscles. - Fibrin.' Albumen. Oil, and combus- tive matters. Inorganic ingredients, (saline and mineral) Water. [By respiration. By secretion. By nutrition. By foreign matter. Excessive-Hyper- trophy. Deficient-Atro phy. Perverted-Degen. eration. STUDY OF DIAGNOSIS. 217. PROXIMATE ELEMENTS OF DISEASE. Deficient in quan- f General. Increased-Sthenic. Dimin'd-Asthenic. Increased-Determi- nation of blood. Dimin'ed-Congest'n. } Inflam. Partly inc. Partly dim. mation The circulating blood. tity-Anemia. Partial. General-Plethora. Excessive in quantity-Hyper- æmia. Partial Perv'ted in qual- Local hy- peræmia. ity-Cachemia. With Circulation With Circulation textures. Degenerations of tissues. Deficient-Atrophy. Nutrition of Excessive-Hypertrophy. Perverted. Morbid deposits. Morbid growths. If now we add to this the ordinary nomenclature of disease, employed in this country, the reader will have before him a brief resume of nosology. It will be seen that these various classifications point the way to certain necessary studies, having reference to causes of disease, their general expression, their influence on the func- tions of life, and lastly the technical language by which they are designated and known. It will be recollected that diseases are first divisible into general and local, and the first may be arranged according to the classification of Wunderlich as follows: Tabes. Chlorosis. Scorbutis. * Dropsy. General Disease-Dyscrasia. Diabetes. Rheumatism. Pyæmia. Tuberculosis. Carcinoma. Lesions induced by {Specific Agents Vegetable Substances. 19 218 STUDY OF DIAGNOSIS. K Periodic. Intermittent. Remittent. Yellow. Febricula. Synocha. Fevers. Continued. Synochus. Eruptive. Scarlatina. Typhoid. Typhus. Variola. Contagious. Rubeola. Spotted. Zymotic. Cerebro-Spinal Meningitis. Diphtheria. Erysipelas. Local diseases are usually arranged in groups accord- ing to the function of parts. This seems to be the most natural arrangement, as the expression of disease is frequently a wrong of function. Of the Nervous System. Of the Brain. Spinal Cord. Sympathetic. Structural. Functional. Eye-sight. Ear-hearing. Of the Organs of Special Sense. Nose-smelling. Mouth-taste. Skin-touch. Nose. Pharynx. Larynx. Of the Respiratory Apparatus. Trachea. Bronchia. Lungs. Pleura. Heart. Pericardium. Arteries. Of the Circulatory Apparatus. Capillaries. Veins. Functional. Structural. Functional. Structural. Functional. Structural. Lymphatic Vessels. Lymphatic Glands. STUDY OF DIAGNOSIS. * 219 Functional. Structural. Mouth. Salivary Glands. Tonsils. Pharynx. Esophagus. Stomach. Of the Digestive Apparatus. Small Intestine. Large Intestine. Liver. Spleen. Pancreas. Peritoneum. Supra-renal Capsules Kidneys. Of the Urinary Apparatus. Ureters. Bladder. Urethra. Functional. Structural. Structural. Functional. Functional. Structural. Of the Reproductive Organs. Scrotum. Testes. Vesiculæ Seminales. Prostate. Penis. Ovaries. Uterus. Vagina. Vulva. [ Urethra. Cutis Vera. Rete Mucosum. Epidermis. Of the Skin. Sudoriferous Glands. Sebaceous Follicles. Hair. Nails. Bones. 1 Of the Organs of Locomotion. Articulations. Cartilages. Muscular Tissue. Fibrous Tissue, Connective Tissue. The reader will notice that whilst this classification is exceedingly simple, it directs attention to the part diseased, the function impaired, and in so far as reme- dies act on particular parts, it suggests appropriate 220 STUDY OF DIAGNOSIS. remedies. In ordinary professional consultation it proves sufficient, as it does in writing, and it is quite sufficient to satisfy the popular demand for names. GENERAL CLASSIFICATION We will make a study of disease according to the four general divisions heretofore named. 1st, with ref- erence to the cause-epidemic, contagious, endemic, spo- radic; 2d, as it is general or local; 3d, as it is structural or functional; and 4th, as it shows a departure from the physiological standard. In doing this the special features will be so pointed out, that the reader will be enabled to recognize the divisions, and classify his cases according to them. It is possible that the description will be at times longer than is really necessary for the purposes of diagnosis, as we wish as far as possible to study the natural history of disease, but it will be made as con- cise as possible. EPIDEMICS. A thorough study of epidemic influences has not yet been made, and we know much less of the subject than we should, yet what we do know has an important bearing upon practical medicine. Many physicians have recognized the fact, that the conditions of life do change from time to time, and that as the result of this there are variations in the wrongs of life diseases-and in their expression. That in some years and seasons, these changes were so great as to give that character to disease which is usually known STUDY OF DIAGNOSIS. 221 as epidemic. The fact has been recognized, that this epidemic condition might influence but one disease, or a class of diseases, as those called contagious, those called zymotic, or it might influence all diseases or pathological states. The general epidemic influence is known by some special character of disease, which is wide-spread, and is noticed in many localities. In some cases it will be seen as a condition of asthenia, in others of undue ex- citation. In some it partakes of the zymotic character, and this influence upon the blood is noticed in a majority of cases of acute disease. Physicians will re- collect it under the name of typhoid, giving a peculiar character to fevers and inflammations, and even noticed in minor affections. · This epidemic influence is frequently marked by special symptoms calling for special remedies. Thus the diseases of the Winter of '72-73 were characterized by a peculiar frontal pain, frequently localizing itself in the left orbit; a peculiar appearance of tongue, with prominence and redness of the papillæ of the tip; the tendency to erythematous redness and inflammation of skin and mucous membranes. Epidemic remedy-. Rhus Toxicodendron. The present year, 1873–74, we notice the common basilar pain, and the impairment. of the venous circulation-fullness of veins, a pecu- liarity of pain, especially of right side, and affection of serous membranes. Epidemic remedies-Podophyllin, Bryonia. In 1870-71, we noticed especially the deep coloration of mucous membranes, the tendency in severe disease to brown tongue and sordes. Epidemic remedy-Muriatic Acid. To diagnose this epidemic influence, one must be a 222 STUDY OF DIAGNOSIS. } reader of the periodical literature of the day, so as to see the expressions of disease in different localities. It is true that observations are made without reference to this, and the reporters do not believe in it, but the evidence is all the more valuable. No one can take a half dozen of our medical periodicals, and compare them for a series of years, without being struck with a certain similarity in the diseases of a year, or a series of years, which can be accounted for in no other way. It would be possible from our periodical literature to tabulate the character of these epidemic influences for a considerable period of time, and this no doubt will be done in the future. The reader will have no doubt observed, that the dis- eases of some seasons, no matter how diverse in special characteristics, would have something in common, which something would be especially manifest in the treatment. That in some seasons Quinine would cure everything, in others the sedatives would cure every- thing, in others a remarkable benefit from Podophyllin, so that when you had once determined a good treat- ment, you would persist in it for all affections, with very little modification. And this brings prominently before us the fact, for fact it is, that there is an endemic or epidemic consti- tution of disease, that should be well studied, and always regarded in treatment. Success or failure will very frequently depend upon this knowledge, and it is something that must be relearned every year. It was a prominent doctrine of Rademacher and his followers, and he had remedies for three such constitu- tions. These were Iron, Copper, and the Nitrate of Soda. There was some truth in this, how much I don't - 1 STUDY OF DIAGNOSIS. 223 know, for I have not had the opportunity to experi- ment, and, indeed, have not had time to give his works the examination they should have, as I read German slowly, and they have never been translated. I believe, however, I have passed through one year, in which Iron was the remedy for almost everything, and I think probably some of our old practitioners may recollect it, if they by chance had used Iron. The season commenced in December with a large num- ber of cases of erysipelas, for which Iron was a specific, and for some fourteen months I prescribed Iron daily for almost everything, with the most flattering results. I have experimented with Copper and Nitrate of Soda to but a limited extent. Rademacher applied the principle to chronic disease. Grauvogl says: "One experience gained by this school is worthy of special consideration-that, in old chronic diseases, the previous epidemic constitution always decides, first of all, upon the present indication of a remedy, hence, in every case which comes up for treatment, the time of its first appearance should be learned, as far as possible, for, by this, frequently, if the then epidemic curative remedy is known, the primary seat and the primary kind of the diseased process are known also, and this very remedy will still effect a cure, if a cure is yet possible, or, if the disease is not already succeeded by another disease of the first affected organ or blood, or if disease of another organ has not ensued. But, even in this latter case, that knowledge gives the point of departure for the whole chronic affection.' "That is in gross, what we see happen on a smaller scale, after strong or oft-repeated doses of long-acting : 224 STUDY OF DIAGNOSIS. remedies. First appear symptoms at the point of application, then of its reception in the blood, finally, the affections of the specifically affected organs and systems in succession, and often, at great intervals, as we have observed very distinctly with quicksilver, for instance. The only difference consists in this, that epidemic injurious influences, often after very many years, to the surprise of many, bring to view their con- tinued operation as a token of the presence of their re- sults under various forms of disease, while the continued operation of drugs is of proportionally shorter dura- tion." If this theory of epidemics is borne out by future observation, it must have an important bearing upon therapeutics. If we determine a common element in the diseases of a season, we will have something common in the remedies. If we have an underlying influence of this kind, giving character to disease throughout a considerable extent of country, it is an influence that should be known, and have due weight in our estimate of pathological processes. If we can go still further, and find certain epidemic remedies opposed to this in- fluence, whatever it may be, it will greatly aid our treatment. I am not only satisfied that we have these epidemic constitutions of disease, but that we have epidemic. remedies as well. And going further than this, I believe with Rademacher, that this epidemic influence persists in chronic disease, and that the knowledge of the epidemic influence at the time the disease com menced, may give us in the epidemic remedy of that year, the means of cure. We need not re-discuss the change of type theory, STUDY OF DIAGNOSIS. 225 and yet I have no doubt but that disease does change its type; that for a number of years it has the char- acter of asthenia, and for another period it will be sthenic. The knowledge of this will be available in the selection of remedies. Again we find years in which the peculiar wrongs known as typhoid are prominent. All acute diseases seem to partake of this character, and if of consider- able duration, typhoid symptoms will be developed. We have "typhoid pneumonia," "typhoid dysentery," intermittents and remittents run into typhoid, as well as other discases. This epidemic influence is readily recognized, and suggests treatment. Zymotic diseases are not unfrequently epidemic, or have underlying them the epidemic character. It is true they frequently produce a specific contagion, which serves as a cause of their propagation, and this we wish to keep distinct from the character we are now studying. The epidemic influence is that which renders the com- munity very susceptible to the contagious poison, or gives it specific characters, or renders it more destruc- tive to life. } Readers will readily recall epidemics of this character. Seasons in which smallpox, scarlet fever, measles, whooping cough, were remarkably prevalent, easily transmitted, difficult to protect against, possessed dis- tinctive features, and required special treatment. And they will likewise recall the fact, that in these years other diseases would show similar peculiarities, and would require similar remedies. This will have been noticed in local complications, as well as in the general features. That in some years there was a remarkable tendency to disease of the respiratory apparatus, or of 226 STUDY OF DIAGNOSIS. + the bowels, or of the kidneys, or of the nerve centres, and that these local affections were to be met with as complications of all diseases. I have already noticed the fact that such epidemic influences may be discovered in chronic diseases; that many times the disease will partake to a greater or less extent, of the epidemic constitution of the year in which it was contracted, and will require the epidemic remedies of that year in its treatment. Indeed, in some cases, we find that determining this, and knowing the constitution of disease at the time it commenced, and the remedies that were curative then, we have de termined the remedies which will prove curative. It is not only important to thus be constantly on the alert to determine the presence of epidemic influences, and carefully note the expressions of disease at such times, but it is well to keep memoranda for future use. It is true that all disease has distinct and definite ex- pression, and that for this we may find distinct and definite remedies; quite as much for this epidemic con- stitution of disease as any other. We are acquainted with quite a number of epidemic remedies, and find the list continuously enlarging. So marked is the influence, and so distinct the features, that we sometimes find a single remedy sufficient for the entirety of disease. It is possible that we may make the best study of remedies in such seasons, for I have noticed that if a remedy has thus proved markedly curative at such times, the epidemic symptoms indicat- ing it being pronounced, the remedy would prove cura- tive in sporadic, endemic, or contagious diseases, wher- ever the special symptoms were present. The remedies worthy of special notice in this con- STUDY OF DIAGNOSIS. 227 1. nection are Quinine, Muriatic Acid, Soda, the Antisep- tics, Sulphurous Acid and Sulphite of Soda, Chlorate of Potash, Baptisia, Aconite, Veratrum, Belladonna. Gelseminum, Rhus Toxicodendron, Iron, Nitric Acid, Podophyllum, Lobelia, Bryonia, Nux Vomica. All of these, and such others as may have attracted the attention of the reader as being especially useful in certain years, may be advantageously studied in this connection. CONTAGIOUS DISEASES. In this classification we find that certain diseases are produced by a specific cause, generated during the pro- gress of the disease, and propagated from person to person. In them we find that the contagious element is continuously reproduced in kind, and the expressions of disease are alike. As before noticed, it may and does vary from epidemic influences, and as we will hereafter see, from endemic influences, but in general features there will be a remarkable likeness, and in therapeutics there will be something in common. The diseases grouped under this head are the crup- tive fevers-variola, rabcola, scarlatina, varicella; the contagious cough-pertussis-whooping cough; some zymotic diseases-erysipelas, puerperal fever, diphthe- ria, spotted fever, cerebro-spinal meningitis; some fevers and inflammations, cholera, typhoid, typhus and yellow fevers, inflammations with typhoid symptoms The general diagnostic feature is that the disease can be traced from person to person, and when the fact of exposure is known, we are justified in giving it the 228 STUDY OF DIAGNOSIS. care, and using the precautions against the spread of contagion that may be necessary. These diseases have certain distinct expressions by which they may be known, and when we have a first case, the contagious element will receive due considera- tion, especially in guarding against its communication to others, in some cases by the use of appropriate pro- phylactic means. We also regard the fact, that the contagion generated during the progress of the disease may unpleasantly influence the patient, indeed his lifo may be destroyed by its presence with and around him. VARIOLA.-The diagnosis of smallpox will be made by—a, the intense, aching pain in all parts of the body, deep seated, during the first day of febrile reaction; b, the appearance of the eruption, as distinct red spots, which give to the touch the sensation of hardness like a shot under the skin; c, the regular development of the pustules in a period of nine days; and d, the flat- tened and umbilicated form of the pustules. It suggests protection by vaccination, by avoidance. of the cause, by the use of proper antiseptics. In the treatment of the disease, that the contagion be removed, as far as possible, by the excretory organs, and at length by the completed stages of the eruption. When the contagious virus is in large quantity, as shown by the usual evidences of decomposing animal matter, it suggests the use of antiseptics, agents that destroy the material of contagion, great cleanliness, and a sustain- ing treatment. RUBEOLA.-The diagnosis of measles will be made by-a, the catarrhal symptoms, full, suffused and in jected eyes, which announce the attack; b, the pecu STUDY OF DIAGNOSIS. 229 liar and constant cough; and c, the irregular form of the eruption. It suggests Lobelia and Asclepias to favor the deter- mination of the eruption upon the skin, and relief of irritation of mucous membranes, and Drosera as the special remedy for the cough. SCARLATINA. The diagnosis of scarlet fever will be made by-a, the early appearance of a sore throat, which persists and is a marked feature of the discase; b, the high range of temperature, and dryness of sur- face; c, the vivid scarlet redness of the eruption; and d, the evident impairment of the cutaneous capillaries, as marked by the persistent white line left as the finger is drawn over the surface. It suggests Belladonna in minute doses as a prophy- lactic, Belladonna and Carbonate of Ammonia as stim- ulants to the capillary circulation of the skin. And the use of fatty inunction alone, or with stimulants— Creosote and Common Salt. VARICELLA.-The diagnosis of chicken pox will be made by―a, the irregular appearance of the points of eruption; b, their speedy development; and c, their vesicular form. PERTUSSIS―The diagnosis of whooping cough will be made by—a, the occurrence of cough without febrile symptoms; b, its paroxysmal and spasmodic character; and c, the whoop, the sibilant or whistling sound as the air is forcibly drawn through the contracted larynx during or at the close of the paroxysm. It suggests specific remedies, Drosera, Belladonna, 230 STUDY OF DIAGNOSIS. 1 Nitric Acid, and Trifolium Pratense, as may be indi- cated in each case by special symptoms. ZYMOTIC DISEASE. Whilst all contagions may be classed as zymoti, all zymotic diseases are not conta- gious. Those named-erysipelas, diphtheria, spotted fever, and cerebro-spinal meningitis-may be epidemic, endemic, or contagious, and we study them in each of these classes. When they prove contagious, it may be from either of two conditions-the intensity of the dis- eased action, or the loss of life and breaking down of the tissues. If we take the first disease, erysipelas, we will find that it sometimes develops remarkable virulence in this direction; so much so that it will attack almost every surgical case in a hospital, and will be contracted by nurses and others. This of course will be noticed espe- cially in certain years (epidemic influence) and in cer- tain localities (endemic influence), but we can not neglect to notice the contagious element. In the one case we notice the intensity of disease, both as to its local and general symptoms. The part is in- tensely hot, burning, painful, and is dry and tense, and its color, whether bright or dark, is vivid. The pulse is frequent, tense, and unyielding, the temperature has a high range, and the nervous system shows great exci- tation. Whenever such symptoms show themselves, we may fear contagion, and will employ means to pre- vent the infection of others. In the second case we have the evidences of sepsis and deliquescence of tissue. Locally the part is full, and wants elasticity, the epidermis yields, and presently the connective tissue The discharge becomes offen- STUDY OF DIAGNOSIS. 231 sive, the pulse oppressed and feeble, and the tissues at large softened. Whilst in the first case remedies would have reference to the intensity of diseased action, and consist princi- pally of the five specifics-Iron, Veratrum, Rhus, Apis, Belladonna; in the second it will consist in the use of the proper antiseptics, with restoratives and food. In the second, puerperal fever, we notice the same two elements of contagion, quite as marked as in crysipelas. But there is added a third, an infectious material thrown off from the reproductive organs. So marked and virulent is this, that it is readily communicated by the physician from patient to patient, even through an interval of days or weeks. It is not only thus infec- tious, but is intensely poisonous to the patient, and its re-absorption intensifies disease, and frequently leads to a fatal result. Having regard to the means named in erysipelas, the physician gives especial attention to prevent the spread of contagion. In some cases this may be avoided by strict attention to cleanliness, change of clothing, and the use of antiseptics, as washing with a solution of Chlorate of Potash, Sulphite of Soda, Labaraque's Solution, or dilute Sulphurous Acid. To prevent re- absorption, we use great cleanliness, and the antiseptics just named. In diphtheria the contagious property seems to be developed more by the intensity of disease, than by devitalization of tissue and putrescence, and it is always well to use extra precautions when the febrile action and local inflammation are intense. But here as in puerperal fever a specific infection is generated at 232 STUDY OF DIAGNOSIS. the point of local disease, and is readily communicable to others. This is so marked that the diphtheritic de- posit is readily inoculable, not only in the throat, but on almost every abraded surface. The knowledge of these facts will not only cause us to guard against the general conditions of contagion, us in the other cases, but especially against the trans- mission of the local infection by coming in immediate contact with the patient and inhaling the breath, the use of towels, handkerchiefs, before they have been thoroughly. purified by boiling, and especially the use of probangs, swabs, or surgical instruments that have been employed on a diphtheritic patient. In cerebro-spinal meningitis and spotted fever we have the double element of contagion first named. The generation of the infectious material by intensity of disease, and by loss of life in tissues, and putrescency. The same means will be employed as in the case of erysipelas, both to prevent the spread of contagion, and to protect the patient against the poison generated in his own body. CHOLERA.—Asiatic cholera might be studied in the class of epidemic diseases, as in the seasons of its prev- alence there is a marked epidemic influence, that shows ´itself in other diseases as well as this. But though we recognize this, the evidence that it is propagated by a specific contagion is too well proven to allow us to neglect it. Cholera advances on lines of travel, and renews its strength as it goes, going with people, being propagated by and in people. Gaining strength and virulence by special combination of circumstances in its native country India, it takes passage by steamship STUDY OF DIAGNOSIS. 233 to Europe, from Europe to America, where it is dis tributed by railroad, steamboat and stage. It is probable that the infectious poison is found prin- cipally in the excretions, and mainly in the dejections from the bowels, and the disease is especially propagated from them. If so, it points the physician to the neces- sity of especial care in the removal of the dejections, and that they be so disposed of as not to endanger others, either by their exhalations, or by contaminating the water supply. We diagnose an attack of cholera by-a, the great exhaustion that attends the first discharges; b, by the evidences of imperfect circulation and aeration of the blood, as seen in the bluish discoloration of the ex- tremities; c, by the want of color in the fæces, “rice water"; d, by the marked enfeeblement of the circu- lation, and lowered temperature; and e, by the exces- sive thirst, nausea and vomiting, and muscular cramps. TYPHOID FEVER and acute diseases assuming typhoid symptoms, usually possess the contagious element in slight degree. Yet in some cases we observe a remark- able development of this character which demands the attention of the physician. Typhoid is generally thought to mean asthenia, but it is better to think of it as having reference to sepsis of the blood. With the condition of sepsis, comes the property of contagion, and under some circumstances this becomes marked. think diseases called typhoid will be found to develop the character of contagion both from intensity of dis- ease, and from impairment of the life of tissue and putrescence. The most marked cases I have known were when there was great nervous excitation, tense 1 234 STUDY OF DIAGNOSIS. tissues, high temperature, and the sensation of pungent heat when the hand was applied to the surface. The other cases are distinguished by a peculiar sweetish cadaveric odor of breath, dark fetid fæces, and fetor of urine. TYPHUS FEVER is markedly contagious, and may be wholly propagated by a specific contagion generated during the progress of the disease, and thrown off in the excretions both from bowels, kidneys, skin and lungs. It has been noticed that here intensity of dis- ease, marked by great febrile excitement, was more likely to develop the contagious element, than the con- dition commonly known as putrescence. YELLOW FEVER is undoubtedly contagious in degree, sometimes very markedly, and at others so as to exert but little influence. Both conditions of contagion have been noticed that from great intensity. of disease, with the symptoms heretofore named, and from putres- cency appearing in the last stage with the black vomit. ENDEMIC DISEASES. If disease showing distinct peculiarities is confined to a locality, it is said to be endemic, especially if it prevails to any considerable extent. In such cases the cause is evidently local, and it is evident that many times it may be discovered, removed, or avoided. These diseases have a definite and distinctive expres- sion, which should and may suggest the means of cure. In some the endemic influence is so wholly the cause, and the endemic expression so clearly indicates the STUDY OF DIAGNOSIS. 235 1 lesion, that remedies will be remarkable for their cura- tive influence. At other times the endemic influence, and disease produced, will be but a part of the wrong, and whilst the endemic remedies are important, they. are not so certain as before, and have to be aided by other means. The diagnosis of endemic disease is usually very clear: a, There is something distinct and special in the expression of disease; b, there are a number of cases, showing these special features; c, the diseases are re- stricted to definite localities. First among the diseases included in this classifica- tion are all those showing periodicity, including inter- mittent, remittent, and yellow fevers. Following these, we find that an endemic influence may give rise to the serics of continued fevers, to all inflammations, and to many functional and structural diseases. And it is to be noticed that as a rule the endemic influence intensi- fies the natural disease in addition to giving it special features. I PERIÓDICITY.—Whatever may be the cause of period- icity in disease, the fact is sufficiently tangible, easily recognized by the periodic expression, which indicates a special pathological condition, and calls for a special group of remedies, anti-periodics-Quinine. As before remarked, the periodic element may serve as a basis of nearly every named disease, which will be cured by the one remedy, Quinine. Or it may only be a complica- tion, or part of the disease, and Quinine will only be one of the remedies called for. But periodicity does not always mean Quinine, and it is sometimes difficult to determine whether it does or not. All diseases are 236 STUDY OF DIAGNOSIS. A periodic to a certain extent, having periods of increase and diminution, as may be noticed even in the fevers called continued. Indeed all the functions of life, both in health and disease, have something of periodicity in their performance. The diagnosis of periodicity will be made by-a, The marked remission or intermission of the evidence of disease, and return to the healthy standard of life; b, the equally marked exacerbation of disease, especially with reference to the wrongs of innervation, tempera- ture and circulation; c, the disposition to continue such functional aberrations without change of structure; and d, the fact that such disease is endemic in the locality. INTERMITTENT FEVER.-We diagnose an ague by-a, the marked cold stage; b, followed by a hot stage; c, a sweating stage-all occupying a comparatively short time, usually less than twenty-four hours; and d, a more or less complete intermission of the disease, and return of normal functional activity. If the intermission is complete, with normal temper- ature, normal circulation, innervation and secretion. Quinine will be the remedy. If functional wrongs should persist during the intermission, appropriate means should be employed for their removal, and the Quinine given if the disease persists. Remittent FevER —We diagnose remittent fever by -a, A forming stage which may be brief or of one or two weeks duration, and which is frequently attended by gastric disturbance, and frontal pain; b, a chill, not nearly so intense as in ague, but well marked; and c, a hot stage which is distinctly broken up into remissions STUDY OF DIAGNOSIS. 237 and exacerbations, and continues to the sweating stage, which is the termination of the disease. The distinct remissions and exacerbations-periodi- city-mean's Quinine, and in some cases this remedy will be sufficient to arrest the entire series of morbid processes. This condition will be known by-a, The soft and open pulse; b, the moist and cleaning tongue; c, the soft and moist skin; and d, return of normal in- nervation—at the remissions. If these conditions do not present, we determine the character of the wrongs and employ the means necessary to remove them. YELLOW FEVER.-Though there is undoubtedly an epidemic influence in some seasons, and the disease is more or less contagious, we find that the endemic con- ditions are of great importance. Yellow fever can not prevail in unfavorable situations, (it is said never to prevail at altitudes of more than four hundred feet above the ocean), and just in proportion as the local influences favor it, the disease will be severe and fatal. Bad drainage and want of cleanliness are especially noted as likely to favor the propagation of yellow fever. The diagnosis of yellow fever is made by—a, The marked chill, attended by lumbar and frontal pain, nausea and vomiting; b, the rapid accession of the hot stage which is very intense, lasting from twenty-four to seventy-two hours; c, the abatement of febrile ac- tion, but with marked prostration, and gradually in- creasing yellowness of skin; and d, the return of nau- sea and vomiting-the black vomit. TYPHOID-Next to periodicity the most frequent and marked endemic influence is that which gives the 238 STUDY OF DIAGNOSIS. 1 typhoid character to fever. It may produce typhoid fever with disease of Peyer's glands, may cause typhoid· symptoms in remittent fever, and all the inflammations. A very common manifestation of the influence is in typhoid dysentery, and typhoid pneumonia. The local cause is evidently decomposition of vegetable and animal mat- ter, the products being thrown off into the air and in- haled, absorbed by food, or infecting the water supply. As it is possible to remove such causes, the physician should. always direct attention to them in these cases, that they may be removed. Using the word typhoid as an adjective to designate a condition of disease, it has reference to the condition of sepsis and putrefaction. The enfeeblement or asthe- nia is but an incident, and is sometimes not, noticed until a late stage, though the typhoid symptoms are marked. The diagnosis is best made by examining the exuda- tions or secretions. It is especially marked in the mouth; on the tongue by dirty coating, or a fur that assumes a brownish tinge and gradually becomes deeper until it is almost black; dirty or dark sordes upon the teeth; unpleasant, dark, and offensive fæces; urine that is frothy, and gives an unpleasant cadaveric odor. We also notice it in the sense of pungent heat when the hand is applied to the surface, and in the low de- delirium. In surgical diseases, the discharge from wounds or injuries, or operations, will show it, in a wrong of the pus, which becomes thin, ichorous, fetid, and in a tendency to softening of tissues and sloughing... It suggests the class of antiseptics, especially Sulphite of Soda, Sulphurous Acid, Muriatic Acid Chiorate of Potash, and Baptisia, which are selected wcording to special indications hereafter named. STUDY OF DIAGNOSIS. 239 We also find special expressions of disease, when endemic, that indicate special remedies, and these prove curative. As in the case of epidemic influence, we find that these symptoms are common to many or nearly all the diseases of the season or year, and the remedy in- dicated assumes a very prominent place in treatment. Thus all the remedies named as being indicated in epidemics, are found indicated when the cause is endemic, Thus we sometimes find an erysipelas, puerperal fever, or dysentery, that is clearly endemic, and the special indications for remedies will be distinct. We want Iron, Veratrum, Rhus, Podophyllin, etc., and the indications are so direct and positive that a cure is cer- tain and speedy. SPORADIC DISEASE. In this last class we find no special expression of disease, or in other words, we find the regular succes- sion of symptoms as given by authorities. The causes are in the acts or indiscretions of the individual, in ex- posure to heat, cold, wet; want of proper clothing or protection; intemperance in eating and drinking; over- exertion, physical or mental-and the reverse, a want of exercise. Or the cause may be found in the general conditions of life; sudden changes of temperature; more or less moisture in the atmosphere; and a greater or less electrical condition. These causes are temporary, and avoidable, and it is well to study them in relation to disease. Whilst a man may not escape an epidemic, contagious, or endemic 240 STUDY OF DIAGNOSIS. cause, right living will usually prevent the class of dis eases called sporadic. It is also well to notice that these diseases are usually simple in their structure, and very amenable to reme- dies. If we take the physiological study of disease, and determine which is the first wrong of function, and right it, we will have but little trouble in treatment. A sporadic fever yields readily to the special sedatives-- agents that rectify the wrongs of the circulation; or at farthest will need but the help of those which increase secretion. An inflammation readily yields to the gen- eral sedatives, and those which remove the irritation of the part. The important points to determine in these cases are the character of the general disease, and the remedies which will right it; the situation and character of the local disease, and the remedies that will influence the part, and influence it in a right direc- tion. GENERAL AND LOCAL DISEASE. This would seem to be a very simple and profitable classification, both in determining the character and gravity of disease, and in selecting remedies. Yet when we come to the bedside we find it very difficult to make the diagnosis. Disease may be so uniformly distributed, that it is impossible to say that one part suffers more than another, or it may be so localized and restricted to a part, that its general influence is hardly noticed. Yet in most cases we will find the two associated together. It is difficult to find a person so uniformly constructed that there is not some weaker part, and in disease which otherwise would be general, STUDY OF DIAGNOSIS. 241 this weaker part suffers. If it were not so, the happy man would be like Dr. Holmes' "one horse shay," and like it would fall to pieces at once, somewhere between three score and ten and five-score years. And there is no part so disconnected with the organism as a whole, that can suffer disease without influencing the body at large. Though the body, so varied in function, is one, yet it is of advantage to think of disease as being general and local (in principal part), and associate with these ideas thoughts of general and local remedies. To get a fair conception of the elements of general disease it is well to think of those functions which are common to the entire man, or which are equally necessary in their results to the entire man. And to get a fair con- ception of local disease, we study the function of each part, in so far as it can be dissevered from the life in its totality. We might make a group of the elements of general disease, according to our physiological classification, somewhat as follows: Formative-for organization. Force. Heat. Electricity.{Conditions of life and motion. Increased, In its circulation. Diminished, Wrong in kind. The Blood. In its organization.(with reference to nutrition, to degenera- tions, deposits and growths. Influenced by Retained excreta. Malaria. Zymctic poisons Specific poisons. For the supply of Oxygen. The Respiratory Function. For the removal of Carbonic Acid. innervation: As an aid to the circulation. From the sympathetic, co-ordinating the vegetative process. From the spinal cord, as infiuencing the automatic functions. From the Brain, Reason. Emotion. Volition. : Sensation. 21 : ? 1 242 STUDY OF DIAGNOSIS. It is not necessary to consider each of these in this place, but having them grouped before the eye, the mind can analyze each one as a factor of disease, and combine them in natural groups, as usually seen. The mind not only recognizes them as general elements of disease, but will soon learn to recognize the common expressions of wrong, according to the classification of excess, defect and perversion. And it will soon go further than this, recognizing remedies which reach cach in. dividual element, and do that necessary to be done― opposing the morbid action and influencing the func- tion toward the normal standard. If there is an ex- cess-above, the influence is to bring down to the stand- ard of health. If there is a defect-below, the influ- ence is to elevate or bring up to the normal standard. And if there is a perversion-a departure from, the in- fluence is to bring back to the normal standard. We have already noticed that none of these elements of general disease can exist without producing more or less of local disease, and we may also say without influencing the entire series named. With reference to local disease we find it severe and destructive in proportion to the severity of the general lesions. So too we find that the influence of some of these clements of disease sets up a series of lesions which are severe in proportion to the severity of the original one. In both cases general remedies are most important, and in so far as they rectify wrongs, and restore normal struc- ture and function, they are most important. In some cases the general lesion determines the character of the local one. This is especially the case when the general lesion is of the blood, giving caco- plastic or aplastic deposits. An inflammation may STUDY OF DIAGNOSIS. 243 spring up, simple in its character, from the common causes, and if there had been no wrong of the blood, it would have readily passed away by resolution. Yet, there being cacoplastic material in the blood, this is thrown out as an exudation, and breaking down, causes most serious destruction of tissue. If in such cases as this the character of the general lesion were recognized early, and proper means employed to remove the im- perfect material by way of the excretory organs, and so improve digestion and blood making as to prevent its renewal, the local lesion would be less severe and destructive. In place of a "white swelling," or CC mor- bus coxarius," the inflammation would run its regular course of six to nine days to resolution. If we take the case of phthisis pulmonalis, we find another good example. Say there was an original want of formative force, and in consequence there is continu- ously produced an imperfect material in the blood. Its deposit in the lungs comes whenever from any cause excretion is arrested, preventing its normal removal, and when an irritation of and determination of blood to the lungs is set up-the material being carried to the lungs and there excreted. In this case a rational practice of medicine looks first to an increase of forma- tive force, getting thereby a better blood, better tis- sues, and a stronger life. When the disease has once developed itself, the treatment will of course look to the establishment of the processes of combustion and excretion-removing the material from the blood in this way-and the arrest of irritation of the lungs, which is the cause of the deposit there. If we take the single factor, heat, as the example, we find the very same state of affairs. If, for instance, we 244 STUDY OF DIAGNOSIS. have the lesion of the blood known as · typhoid," we find that its increase is in proportion to the wrong of the temperature. If we have an inflammation of the lungs, the local disease is destructive in proportion to the increase of temperature. If we have a phthisis pulmonalis, the deposit is rapid in proportion as the temperature is high, and the destruction of lung tissue is in the same ratio. We say, therefore, that diagnosis by the body thermometer, must suggest a class of gen- eral remedies, which will prove efficient in modifying and arresting general and local disease. • There is no doubt but that lesions of excess and de fect of electricity, as a condition of life, and as a force, have a similar influence upon disease. Plus electricity, and we have increased disease by excitation; minus electricity, and we have increased disease by want of excitation. The diagnosis will be formed in most cases by the degree of excitation as manifested by expres- sion, and the proper remedies will suggest themselves to relieve the body of its superabundance, or to employ means which will add to, or prevent its waste. When we study the circulation of the blood as a factor in disease, we see how marked the influence of one of these general wrongs. Given a lesion of fre- quency in movement only, and we find that any morbid process is increased in proportion. Secretion is arrested, the appetite is lost, blood making and nutri- tion are impaired, waste is interfered with, and every cause of disease intensified. Wrongs in the circulation other than frequency, give the same results. Even an unequal circulation of the blood may lead to such serious impairments of function, as to be a cause of death. Evidently the diagnosis of these general STUDY OF DIAGNOSIS. 245 wrongs, and the use of remedies to reach them, are of prime importance. When we study the influence of lesions of the circu- lation upon local disease, we find them playing the same important role. If you have a local disease, in- flammatory or otherwise, it will be to a considerable extent severe and destructive in proportion to the lesion of the circulation. If we have an inflammation of the lungs, it will be severe in proportion to the fre quency and wrong in the circulation. With a pulse of 100 beats per minute, and frce, there is little danger; but with a pulse of 130, small and sharp, there is most serious danger. If in such case, the lesion of the cir- culation can be removed, the local disease will be modi- fied in the same proportion + Continuing on with this classification, attention might be called to the next group-the blood influenced by certain causes of disease. Take first retained ex- creta, and we have a most excellent example of the need of diagnosis by this classification. We are treat- ing an injury, a wound for instance, and everything progresses well, until from some cause one or more secretions are arrested. At once we see a change in the local disease, the part suffers, its temperature rises, becomes painful, the process of repair stops, the exuda- tion is changed in character, the pus is unpleasant, and finally the repair accomplished is broken down, and it may be the part sloughs. Surely it is well to be able to recognize this wrong, and bring such means to bear as will re-establish waste and excretion. Or a person from some common cause may have a simple fever. At first there are no unfavorable symp- toms, and we reasonably expect a speedy convales- 4 t 246 study of DIAGNOSIS, ; 1 cence, but from some cause there is arrest of secretion, which is retained in the blood. All the febrile symp- toms are increased, and in addition we notice in the brown tongue, sordes, etc., the evidence of sepsis of the blood. Here it is well to recognize the importance of this general element of disease, and by early recogni- tion prevent the unpleasant consequences named. Malaria has played a most important part in disease and the reader will at once recognize its importance. Given a case of disease, most simple in form, seemingly, and with this element characterized by periodicity, the disease may go on from bad to worse, until possibly, death results. It It does not make much difference whether it is a fever, an inflammation, or some other disease. If we take inflammation of the lungs, the re- cognition or non-recognition of this element of disease (periodicity), may be that upon which the life of the patient depends. Without remedies directed to this special element, the disease goes on to destruction of the lung tissue. With Quinine properly administered, it runs a brief course, and terminates in resolution. The influence of zymosis is well illustrated by ery- sipelas. You notice the swollen, red, and glistening spot on the skin, and as the patient complains of the peculiar burning, you call it erysipelas. If your atten- tion is not called to the element, zymosis, by the pecu-. liar tongue, pulse, condition of innervation, etc., and you prescribe empirically at a local inflammation, you may lose your patient. Recognizing the zymotic char- acter of the disease, and uniting it with proper reme- dies for this, the patient gets along well. Dysentery is another excellent example of this. In the minor sporadic cases, Podophyllin to catharsis, STUDY OF DIAGNOSIS. 247 White Liquid Physic, or Castor Oil and Turpentine, may serve the purpose, and the sufferer gets well after a time. But do not trust zymotic dysentery to this treatment. Here the wrong of the blood, working typhoid symptoms, is the principal factor of the disease and the element of danger. It is to be met by specific epidemic remedies, or those which we class as anti- zymotic or antiseptic. The influence of specific poisons well illustrates the truth of what has just been said, though the illustra- tion is outside of ordinary practice. The hunter in the Carolina mountains feels something prick his leg, and getting through the brush he pulls up his pants, and finds but a slight wound, and the smarting has already ceased. It amounts to but little as a wound, but if he has heard the rattle of a serpent, or has seen it in the act of striking him, he is at once awake to danger. He has made specific diagnosis, and by sucking the wound, the use of Ammonia, or the free use of Whisky, he provides against the specific poison. We get a practical example of these lesions in the case of syphilis. A man finds a small sore on his penis, which as yet has given him no annoyance, and if he had no experience with such things, he would expect it to disappear as rapidly as it came. But as days go by. it gets larger, and seems more prominent, and after a time comes skin disease, sore throat, falling of the hair, iritis, nodes, etc. Surely there is something more than a simple abrasion here-from a strain. Supposing the physician should only recognize it as a sore, ignoring the specific poison of syphilis, what would be the suc- cess of treatment? And yet he could do this with quite as much credit, as to fail in recognizing the 淼 ​248 STUDY OF DIAGNOSIS. specific wrongs in zymotic dysentery, in typhoid fever, in smallpox, in scarlet fever, or in measles. / If we study the function of respiration in its influ- ence upon processes of disease, we reach the same re- suits. With wrong respiration, every other wrong is intensified; with right respiration ameliorated. There is such a thing as too much oxygen, and consequently increased burning and excitement, just as there is such a thing as blood loaded with carbonic acid gas, and so burdened that the varied functions of the body can not be properly performed. Surely it is worth our while to endeavor to diagnose these conditions, and to em- ploy remedies which directly reach the wrongs and re- move them. When we study the lesions of innervation, we are impressed with their influence upon all parts of the body, and the necessity of directing the mind to them in all forms of disease for the purpose of diagnosis. Whether our senses will detect a lesion, frequently de- pends upon our method of thinking. If the mind. directs the necessary examination, the evidences of dis- case may be quite clear, when otherwise they would scarcely be noticed, and would not make the necessary impression. If we study thoroughly the physiology of the sympa- thetic nervous system, and get correct ideas of its con- trolling influence over all the functions of vegetative lite, we will always direct our observation to those ex- pressions of disease which give information with re- gard to this. Remedies influencing disease through the sympathetic are among our most important therapeu- tic agents, and fortunately the expressions of disease are quite clear. If we commence with the lesions of STUDY OF DIAGNOSIS. 249 the circulation-frequency of pulse, change in its char- acter-lesions of temperature, change in the condition of the skin, some changes in muscular expression, change in the respiratory function, we will find a group of symptoms that are distinct and expressive, and so closely associated with individual remedies, that the remedy is at once suggested by the symptoms. The influence of lesions of spinal innervation is well shown in many cases of chronic disease, where "spinal irritation" is a complication. A disease of the diges- tive or urinary apparatus may seem quite clear and simple-one that remedies will readily reach, and yet when we prescribe them, there is continued failure. We have failed to recognize a "spinal irritation," but from this wrong of innervation, the local disease is continuously kept up. If the special wrong is diag- nosed, and proper means used for its relief, the reme- dies which had before failed with the local disease, are more speedily successful. We get another good example of this in some cases of continued fever, and other low forms of diseasc. A patient is doing well enough, other than he can not sleep from difficulty of respiration. When awake the respiratory function is carried on by the influence of the will, but when this is in abeyance, the automatic · function of the spinal cord is not sufficient. Unless this wrong is recognized, and means employed to rectify the wrong of spinal innervation, the patient will prob ably die. We may get evidence of similar wrong, in one case in retention of urine, in another case in incon- tinence, in a third in convulsions or muscular wrongs, and in all we are impressed with the importance of remedies that influence the spinal cord, and influence 250 STUDY OF DIAGNOSIS. it in the direction of health. It would be most absurd to omit from our diagnosis the evidence of a convulsive tendency, and it would be quite as absurd to omit to look after and recognize any evidence of spinal lesion. When we study the functions of the brain, we find them exerting similar influences over the body at large, both in health and disease. It will not do to under- value a right action of the mind, as an element in the recovery of the sick, as it will not do to undervalue a wrong action of the mind in perpetuating disease. Given a mind at ease and restful, and a patient may recover from disease or injury, which under other cir- cumstances would most certainly be fatal. So true is this that we are always on the watch for symptoms shadowing forth the condition of the brain. The quer- ulous voice, the hopeless voice and expression, the unstable voice, the tone of excitation, the tone of pros- tration, all convey valuable information, which must not be neglected. We find cases in which an emotional wrong may originate or so intensify processes of disease as to en- danger life. A very familiar example of this is found in nostalgia, or "home-sickness." In the late war, it was found that this so influenced disease in the hospi- tals, at times, as to double the mortality; indeed, many times a furlough to go home was the only reprieve from death. In the recent Franco-German war, many cases were noticed. Fernand Papillon writes: "During the last war nostalgia carried off many sufferers among our unhappy prisoners dispersed throughout Germany. It attacked the soldiers and mobiles during the seige of Paris, especially toward the close of it, when privations and successive defeats began to reduce the most robust study of dIAGNOSIS. 251 organizations." I have seen just such cases in private practice, and the hope and promise of a return to home, was the strongest remedy toward recovery. "Hope is an anchor." for many wearied and suffering souls, binding them to this world, lightening their suf- fering, and giving increased strength for recovery. The want of hope is one of the most serious things we have to contend with in disease. To give hope to the sick, is one of the many duties of the physician. It is possible that some may give little credence to the statements regarding the influence of the emotions in disease. And yet every one practicing medicine for some years will have seen the influence of love, fear, anger, grief, etc., so clearly manifested, that there can be no mistake in the matter. I have seen grief so pro- found, that every function of life was seriously im- paired, and unless the current of thought could be changed, there was danger to reason or life. A free outburst of tears might give relief to the overburdened heart (brain.) Every physician in active practice has realized the influence of the will upon disease, and every one will wish to know the condition of this function in serious or protracted disease. The evidence of a strong will, and intention to get well, is a real encouragement to the physician, as the want of will in this direction is a great discouragement. If we recognize a want of voli- tion in severe or protracted disease, we do all we can to call it out and strengthen it, and in so far as we do this our patient is benefited. Even in the treatment of a cough we find this is important. If the patient can be impressed with the importance of controlling the cough by the will, we will find it much easier to check it. 252 STUDY OF DIAGNOSIS. Physicians are always awake to wrongs of sensation though frequently the only idea that follows is, the use of means to obtund the sensibility of the brain. It is true that unpleasant sensations or pain intensify pro- cesses of disease, and wrong the entire body by depriv- ing it of necessary rest, yet many times far less harm comes from this than we would suppose. Indeed, in the larger number of cases it is better that the patients suffer pain, than that they be relieved by the ordinary narcotics. If by the study of pain we can select a remedy for disease, then it becomes a valuable evidence. A remedy in this case looks not so much to the removal of the pain, as to the arrest of the disease of which pain is a symptom. The study of local disease becomes important in that it directs the mind to limited parts and functions, and thus specializes the wrong. We group the most im- portant functions of the body, as of digestion, circula- tion, respiration, excretion, etc., and then study each particular organ or part. If we take digestion, we study the function in the mouth, the stomach, the large and small intestine, and as influenced by liver, pancreas, etc. If a certain group of organs or parts do a par- ticular work, we will find diseases of it announced by wrongs of that work. Thus the wrongs of function point us to the locality of the lesion, and a closer ex- amination determines the particular part or organ in- volved. Knowing the lesion of function we readily determine its influence upon the life in its totality, and upon other parts and functions. It is possible in some cases to provide against these influences, by calling into ac- tion other functions which may be supplementary or } STUDY OF DIAGNOSIS. 253 vicarious. As for example, if the digestive organs are in such condition that they can not appropriate calori- facient food, we may for the time being use alcoholic liquors, which require no act of digestion to furnish heat, until food can be taken. Or in similar cascs, re- quiring histogenetic food or the stimulus of beef-essence, we employ it per rectum. We have similar examples in the relation between the excretory organs-kidneys, skin and bowels. If the function of one is impaired, or there are special reasons why one organ should have rest, we call upon one or both the others, to do additional work. In some of these cases, the vicarious action will free the blood from noxious materials, and thus give a chance for re- covery. In others, the relief of the part from work, gives an organ opportunity to recover its normal con- dition by improved nutrition. In the study of local disease we not only have in mind the influence of changed function, but also that which may arise from a change in the circulation, in- nervation, and nutrition of a part. We can not have an excess of blood in a part, without depriving some other part of blood. We can not have a too rapid cir- culation in a part, without influencing the circulation at large. We can not have an arrest of circulation in a part, without impairment of that blood, and a wrong to the whole of this fluid. We can not have a wrong of innervation of a part, without suffering of the nerve centres and a reaction upon the body at large; as we can not have a wrong of nutrition, or waste, without general suffering from it. As the mind grasps these varied factors of disease, it is better able to appreciate the present condition, and 254 STUDY OF DIAGNOSIS. provide against other phases of disease. We not only want to know the condition of discase at the present time, but we also wish to know, from this, what will be the probable condition to-morrow, or some subsequent time. If to-day we can arrest the wrongs of life now present, and turn the tide toward the standard of health, well. If not, we wish to make provision, so far as we can, against the wrongs of to-morrow or next weck. Further along, we will give the diagnostic features of the general lesions here named, as well as the more important evidences of local disease. The object in this chapter being specially to direct the mind to the advantages of this classification, in determining the real nature of disease, and as being suggestive of cer- tain classes of remedies. As before stated, there are many lines of thought in diagnosis, and we do not wish to get them tangled. We wish to do our thinking methodically, and in so far as we can, we take one at a time. 1 PHYSIOLOGICAL DIAGNOSIS. Some may think the heading of this chapter a mis- nomer, as they can not harmonize the name physio- logical, which means right life, with disease, which is wrong life. But if we explain that in diagnosis we must have a standard to measure from-that is, health. -then the term, "physiological diagnosis," is most appropriate. The most important element here is the point to measure from; without this, diagnosis would be the merest guess work. It might be asked, how we can harmonize this method STUDY OF DIAGNOSIS. 255 with the diagnosis by, and prescription for special symptoms, as described in the first part of this work? If remedies are indicated by special expressions of dis- ease-symptoms-which may be common to many and different pathological conditions-why not employ this, to the exclusion of all other methods? If it is true to any considerable extent, should it not be true in all cases, and furnish the only sure basis for therapeutics? These are pertinent questions, and I doubt not many readers have asked them time and again. If a certain pain in the left orbit, a certain appearance of the papilla of the tongue, and a certain sharp stroke of the pulse, says to us that Rhus Toxicodendron is the remedy, whether the discase be fever, inflammation of the lungs, conjunctivitis, diarrhoea, or erysipelas, what do we want of a physiological standard? True, in such cases we do not want it as a basis for prescription, and if we know enough of the relation between reme- dies and disease, we should not make this a study, at least not as a basis for prescription. But, unfortunately, we do not know enough of this. As far as we know it, we base our therapeutics upon it; when it fails, we must supplement it with other methods. Practical medicine is in its infancy, and until it attains the firm step of adult years, we must second it with all the aids that can give it support. If the reader will refer back to page 216, he will find a table which will serve as the ground-work for this study. We purpose examining the various functions of the body, setting up a physiological standard-health —and measuring from it. We find that all lesions can be grouped under the three heads of-excess, defect and perversion-above, below, from. If once we are 256 STUDY OF DIAGNOSIS. $ able to recognize these departures, and have a know!- edge of the action of remedies upon function, we may make a rational selection. If the condition of disease is "above" the normal standard, we employ those means which will bring it down. If the condition of disease is "below" the normal standard. we employ those means which will bring it up. If the condition of disease is a departure "" from the normal standard, we employ those means which will bring it back. The reader will notice that it makes no diffèrence what "school" of remedies is prescribed from, as it is quite as well adapted to the one as another. Take the gross dose of regular medicine, and the physician using it should know the locality of its action, and the quality of its action. And even when the action is secondary or indirect, this method of prescribing is still good, for the mind associates the secondary influence upon a part or function with what needs be done to restore health. If the modern Eclectic prescribes the usual dose of specific medicine, he has clearly in view its direct ac- tion upon a part or function, and he associates the action of the drug with that which needs be done to oppose disease, and restore health Our Homœopathie brother, with his minute doses or infinitesimals, fre- quently prescribes on the same basis. He knows where the disease is, and he prescribes a remedy which spe- cially influences that part; he knows the character of the disease, and he prescribes remedies which his expe- rience has shown opposes the disease, and favors the return of health. Having thus shown the advantage of this study, as being applicable to all systems of therapeutics, and even adapting itself to each individual expression, : STUDY OF DIAGNOSIS. 257 desire to call attention to its value as a training for the mind, and a study of the phenomena of life. "Think- ing in straight lines" has been our motto, and most certainly this is such method of thought. As we edu- cate the mind, so it will do our work, and this I think one of the best studies. This is a study of life in all its phases. It is a study of normal life, for without this it has no basis. And it is also a critical study of wrong life in all its phases, for this is its end. It may be well to call attention again to the too com- monly received methods of examination and diagnosis -direct and by exclusion. In direct diagnosis the symptoms are marked and point directly to the locality and character of the wrong. But in some cases there are no such direct symptoms, and we proceed to make an analysis of the life before us, questioning each par- ticular part or function, until we have found the seat and the quality of the lesion. This is diagnosis by ex- clusion. FORMATIVE FORCE.-The force of organization is re- ceived by inheritance, and the rule reads-as is this force in the parents, so will be its manifestation in the children. Thus it is sometimes an important element in diagnosis, to know the parentage, and in so far as we can, their physical history. From feeble parents we usually expect feeble children. From parents who have had an imperfect organization, and wrongs of blood, degenerations, deposits and growths, we expect children with like imperfect organization, and with the same tendency to disease. If we know that parents have died of phthisis pulmonalis, or other tubercular disease, a cough or articular irritation has a deeper + 22 258 STUDY OF DIAGNOSIS. signification, and we are wide awake to the necessity of early means for protection. If parents or near relations have had cancer, we view with suspicion any growth that may make its appear- ance. If they have suffered with Bright's disease, diabetes, epilepsy, insanity, or other similar disease, we are advantaged by knowing the facts. The force of organization is very rarely in excess, probably never, as regards the whole man. Once in a while we notice examples. of it as affecting parts. Thus we may have hypertrophy of the adipose tissue; hyper- trophy of bone; of the epithelium; of cellular tissue, taking the form of growths. All of these will be read- ily recognized, though it is not so easy to find reme- dies which will arrest or modify the condition. Still bearing in mind the distinction between the unknown and the unknowable, we may expect to find remedies for even such wrongs as these. The wrong of defect is very common, and met with in many cases of disease. We recognize it in defective or feeble nutrition, parts being small, wanting normal solidity, and lacking the usual capacity of our standard man. The functional activity is usually the measure of the force of organization; for though the organism in such case may for a limited time give a large amount of work, it is rapidly exhausted, and requires much more than the usual time for recovery. We may learn that such defect is inherited; that it is the result of bad conditions of life; that it results from over-work, or is caused by disease. Whilst we can not rectify the present wrong of inheritance, we can pro- vide to a certain extent against this in the children of the future. But in the other cases the treatment is STUDY OF DIAGNOSIS. 259 quite plain-we rectify the conditions of life and make them healthful; we prevent over-work, and remove such diseases as influence nutrition. Following this we observe the great law of development-" as a part or function is rightly used, it gains size and capacity.' As we exert the force of organization, we call into right action that which the person has, and as it is thus normally used, it grows. HEAT. The normal temperature of the human body is 98° and a fraction, say 98.4°. To have healthy life this must be maintained, with but very slight varia- tion; even the change of one degree producing disease. The temperature is accurately determined by the body thermometer, applied in the axillæ, or under the tongue, though it may be recognized less definitely by the touch. Excess of temperature is met with in fevers, inflam- matory diseases, and most diseases accompanied with change of structure. As a rule the excess of tempera- ture is associated with corresponding frequency of pulse, frequent respiration, arrest of excretion, digestion and nutrition. In proportion to the excess of temperature is the activity of causes of disease, of wrongs of the blood, and the tendency to destruction in local disease. Thus to a certain extent, the excess of temperature which we can measure so accurately, becomes a means of diagnosing all the wrongs of life. As heretofore named, when studying the changes of temperature as an element of disease, the saving fea- ture is the diurnal variations in the range. Though in protracted disease it may reach the height of 105° to 107°, at some period of the day, it falls to 103° tc 1 } } 260 STUDY OF DIAGNOSIS. 102°, at others, and in this fall of temperature the per son has a promise for the maintenance of life. Whon the high temperature is maintained throughout the twenty-four hours, the disease is necessarily of short duration, either in a fall of temperature and return to health, or in death. Excess of temperature calls for remedies which lessen the processes of combustion, and provide for the better removal of heat. The relation between the cir- culation and the temperature is very suggestive-as is the circulation, so is the temperature-lessen the fre- quency of the pulse, and you reduce the temperature. Thus the special sedatives are suggested, as among the most prominent remedies. Wrongs of sympathetic in- nervation (excitement) are associated with excess of temperature, and those special remedies, Rhus, Bryonia, Gelseminum, Lobelia, etc., become remedies. Excita- tion of the brain and spinal cord are associated with excess of temperature, and when noticed, call for rem edies which relieve such excitation. Lesions of the blood, especially those of a septic or zymotic character, are associated with excess of temperature, and anti- zymotic remedies are suggested in these cases. The skin is the regulator of the temperature of the body. In the continued evaporation from the surface, excess of heat is removed. With a high range of tem- perature the function of the skin is impaired, and transpiration more or less arrested. Among the ser- viccable means to remove the excess of heat, are those that put the skin in better condition, favoring transpi- ration. Among these means, baths hold a prominent place, and should not be neglected. Excess of temperature is quite as important a factor STUDY OF DIAGNOSIS. 261 in chronic, as in acute disease, and its recognition is an important element in diagnosis. Whatever may be the wrong, a range of temperature of 100° and over, means a continuation of the disease, and eventually a destruc- tion of life. On the contrary, amendment is always preceded or associated with a fall of temperature, and if this is maintained at the standard of 98°, we may ex- pect recovery. Thus in phthisis pulmonalis the range of temperature is over 100°, even in the first stage, and if maintained at this, recovery is impossible. If it can be reduced. and held permanently at or near the nor- mal standard, the patient may get well. There seem to be three factors in this high range of temperature, which require study the frequency of circulation, a wrong in combustion, and a defect in the means for regulating the temperature. In some cases remedies directed to the wrong of circulation is most efficient, as when we employ Veratrum, Digitalis, Cac- tus, Lycopus, etc. In others the wrong is of combus- tion, either in a deficiency of some element of the blood, or in an undue excitation of the nerves govern- ing the respiratory function. For the first we think of Cod Oil, the Hypophosphites, Sulphur, and appropriate foods. For the second, Arsenic, Phosphorus, Rhus, Bryonia, Belladonna, Lobelia, etc. In the third the lesion of the skin is prominent, and calls for such means as will restore normal functional activity. It may be the use of baths-alkaline, acid, stimulant, tonic, astringent, inunction, electricity by Faradization, or the use of internal remedies that specially influence this organ. Deficiency in temperature is less frequently met with, and not so easily diagnosed. If the thermometer in i by 262 STUDY OF DIAGNOSIS. i axillæ or under the tongue, shows 98°, but there is coldness of the extremities and surface, showing in some places not more than 90°, we have determined our case. Or possibly we may find that the normal condition of heat, 98°, can be maintained in a state of rest, but there is little surplus for motion-we have heat as a condition of life, but not as a force. In the. last class of cases, the want of power, with exhaustion and lowered temperature after exertion, tells the story. The Deficiency of heat may be dependent upon want of calorifacient food, upon wrongs of digestion, upon the want of some special material in the blood to facilitate combustion, upon deficient innervation, upon a wrong of the skin permitting heat to be wasted, and upon an impairment of the respiratory function. In our ex- amination of the sick, the mind at once determines a comprehensive plan of examination, and our inquiries proceed in this regular order—with regard to food, with regard to digestion, with regard to the need of special material for the blood, with regard to innerva- tion, with regard to the condition of the skin, and with regard to the respiratory function. Finding the princi- pal wrong, the mind at once turns to the remedies that influence the part and fanction, and selects from them the special agent or agents that do that which is needed to bring the part or function back to its normal condi- tion. Unequal distribution of heat is not quite as important an element of disease as excess or defect, but in some cases plays a not unimportant part. If in long-con tinued and severe chronic disease, we have this unequal temperature-the trunk being too hot, the extremities STUDY OF DIAGNOSIS. 263 1 cold- -no means will prove curative until the tempera- ture is equalized. Physicians may laugh about “equal- izing the circulation," "equalizing the temperature,' but these inequalities are very common elements of disease, and recovery can not take place until they are rectified. Hence sometimes means to restore heat to the part which is too cold, are among the most impor- tant to the cure. Take a protracted case of chronic gastritis or dyspepsia, with continued cold feet, and Capsicum in the stockings may be the remedy, or at least it will put the patient in the way of being bene- fited by others. * There are some peculiarities in the temperature that the thermometer will not recognize. For instance, in some cases of zymotic disease, typhoid and typhus fever, protracted disease showing "typhoid" symp- toms, the hand placed upon the skin gets a sensation of pungent heat, very like that when it is placed upon a surface reddened with mustard, or cantharides. The sensation is very distinctive to most persons, and gives the idea of sepsis, and unnatural irritation of the vege- tative nerve centres. There is nothing more certain than this evidence, whenever it is presented, and we are at once awake to the danger to life, and the neces- sity of means to overcome the morbid process going on in the blood, and to relieve the over-excited nervous system. At once we examine our patient with refer- ence to the indications for the special antiseptic- Muriatic Acid-the Alkaline Sulphite, Sulphurous Acid, Chlorate of Potash, or Baptisia, and with reference to the remedies which influence the nerve centres-Aco- uite, Veratrum, Rhus, Gelseminum, etc. 1 264 STUDY OF DIAGNOSIS. 1 ELECTRICITY, like heat, is both a condition of life and a force for carrying on the various activities of the body. Like heat, it may be in excess or defective, or have an unequal distribution. The diagnosis, however, is diffi- cult, for we have no instrument to measure its varia- tions, as we have in the body thermometer. Excess is determined in part by the unnatural state -. of excitation, there being no wrong of the nerve cen- tres to account for it, and by a peculiar dry and con- stricted condition of the skin. In some rare cases the excess is so marked, that sparks may be elicited by rubbing the head or the surface in a dark room. When the evidence is closely examined we will find that the conditions of life have been such as to produce this condition. The patient has been a hard brain-worker, has lived or worked much in a confined room, heated by a stove, causing dryness of the atmosphere, and at the same time has worn clothing that was a bad con. ductor. Taking, therefore, the symptoms of excitation, the constriction of the skin, and the previous history, the diagnosis is pretty accurate; and if we add to this the evidence of exclusion-no other lesion being found that would account for the symptoms-we are certain of the lesion. The treatment will look to a change in the conditions of life. Less work, good ventilation, a moist atmo- sphere, and cotton under clothing. Then will come the use of appropriate baths to rectify the wrong of the skin. And finally, the use of non-stimulating foods, and appropriate remedies to lessen nervous excitement. Defect in electricity is indicated by opposite symptoms. There is a want of energy, and of capacity for con- tinued effort, that can not be accounted for by any STUDY OF DIAGNOSIS. 265 lesion of digestion, blood-making or nutrition, or by local diseases. The skin is relaxed and atonic, the temperature is inclined to be low, and all the processes of life are performed with less than usual vigor. These symptoms will sometimes be supplemented by a his- tory of the conditions of life. A low situation of house, dampness of living rooms or shops, trades that give a superabundance of moisture in the air, the wear- ing of cotton, the use of non-stimulating foods, exces- sive drains upon the system in the shape of sweating, urination, or seminal secretion, etc. Having thus determined the condition of disease, we at once think of changing the patient's surroundings. He is to have a dry atmosphere, an elevated position if possible, air directly influenced by sunshine, sometimes sun baths, and that kind of exercise which will call into action the respiratory function. This is supple- mented by non-conducting clothing of woolen or silk, by the use of stimulating inunction, or dry friction with the hand, or flannel or silk. The selection of proper food is sometimes quite important, animal foods taking precedence. Some of the restoratives arc use- ful, especially the preparations containing Phosphorus, sometimes Iron, and occasionally the Bitter Tonics. These may be supplemented by nerve stimulants, Qui- pine, Nux Vomica, and agents of like character. CELLULAR PATHOLOGY.-During the past twenty-five years we have heard much of cellular pathology, and it has been proposed to refer us back to these primary forms for the history of all disease. According to some enthusiasts in the study of cell life, we not only need to study disease as manifested in cell life, but our i 23 266 STUDY OF DIAGNOSIS. 1 diagnosis should go back to reach these primary organ- isms. Taking the truism, that all wrongs of life mus be based upon change of structure, and all manifesta tions of life flow from, or are the aggregate of cell life the theory becomes very plausible. But there is this difficulty: Cells are organisms so minute that they are beyond the ken of our grosser senses. True we can bring them into view with the microscope, and to a limited extent we can determine changes of shape, but even this is somewhat difficult. The best microscopist will fail to detect differences in cells, when the expressions of disease may have been of the most marked character. It is possible to determine degenerations, some de- posits, and to a limited extent growths, but many times the diagnosis would be post-mortem, rather than at such period of life as would give any practical advan- tage from it. Even in the case of growths, the micro- scope fails to detect the difference between those which are benign, and those that are malignant. True there are distinctive cancer cells, but then there are malig- nant growths without such cells, as there are benign growths with those which so closely resemble them, that the best observer may be mistaken. The microscope will enable us to recognize some changes in the blood-globules, the presence of white globules, some changes in secretion and excretion, and in the formation of pus, and in so far as it does this, it is a valuable aid. Yet in the main, we find it better to rely upon the more common and gross expressions of disease, especially as these are suggestive of reme- dies. If by conceding that life is from cells, and that as are STUDY OF DIAGNOSIS. 267 these cells, so is its expression, we must be referred to cells in the study of disease, we may go one step further back and say that all life is from molecules, and as are the molecules so is the life, and refer you to the com- pound molecules. Failing in this to get beyond the Iruman senses, we might go a step backward, and en- deavor to fix the life of health and the life of disease in the ultimate atom, when surely we will be lost. Molecular pathology is quite as rational as cellular pathology, quite as easy in diagnosis, and furnishing just as good a basis for therapeutics. NUTRITION.-In studying the diagnosis of lesions of nutrition, we observe the same order. Having clearly before us the factors-food, digestion in mouth, stomach, intestine, the process of blood-making, the circulation, the condition of the tissues with reference to appropri- ation, and even the adverse side, retrograde metamor- phosis. Any one or more of these factors may be wrong, and we desire to so localize it, that we can select our remedy with certainty. It would be most absurd, to give "Bitter Tonics and Iron," when the wrong was a want of proper food; quite as absurd to employ a stereotyped tonic when the patient failed to properly masticate and insalivate his food, or when the lesion was one of the intestinal canal, or a wrong of the circulation. We must know the exact location and character of the lesion, if we are to prescribe with cer- tainty. Many wrongs of nutrition are dependent upon a want of proper food. In this country where food is abundant, it is not usually the want of foods in gross, as it is a want of proper selection and preparation. 268 STUDY OF DIAGNOSIS. *1 As the attention is directed to this matter, inquiry soon elicits the facts of wrong food, or bad cooking in which good food is spoiled, and we are able to set our patient. right. We not unfrequently find that food is wrong in kind, though it may be good in quality, and well prepared. If a man wants animal food, vegetables containing a large proportion of starch will not answer well; if he wants calorifacient food, it does not do to feed him upon beef-tea. Again we must have regard for the power of appropriation by the individual, who may be able to digest certain varieties of food, when he can not others. (: Wrongs of buccal digestion are easily diagnosed in the majority of cases by the history given. The patient eats rapidly, bolting his food," which is not properly chewed or insalivated. Or he may be an habitual tobacco chewer or smoker, and thus by continued abuse of the salivary glands have so changed the character of this secretion that it can not do its work. The treatment of such cases is very plain. The patient must be instructed as to the uses of the mouth, and the necessity of amending his bad habits. Abun- dant time is to be given to each meal, and the food thoroughly masticated. If tobacco has been the cause of trouble it is to be dispensed with in all forms Fre- quently this, without medicine, is sufficient for the cure of severe cases. The wrongs of stomachic digestion are frequently an- nounced by unpleasant sensations which the patient refers to the stomach, and points you directly to the seat of the trouble. We have the evidences of indi- gestion, and a wrong of blood-making and possibly of nutrition, in addition to the localization of unpleasant STUDY OF DIAGNOSIS. OF DIA 269 sensations. Of course the unpleasantness varies in different cases, and has the entire range between sen- sations of fullness, weight, heaviness, to the most ex- quisite pain. But having thus localized the lesion, we have only made a commencement, for it is necessary to know its character, and this may be determined in part by the sensations of the patient, and examination of the tongue and the epigastrium, and by the discharges from the stomach. It is possible first to arrange these lesions in two classes-irritative and atonic-and even to make these classes embrace structural lesions. Probably this is the simplest, as it is certainly the best classifica- tion, because it points out the remedies required. Rem- edies influencing the stomach are readily divided into sedative and excitant-the one removing irritation, and the other giving stimulation. The evidence of irritative lesions is found in uneasi- ness or pain of a somewhat acute character, tenderness on pressure over the epigastrium, and in many cases by injection of the papillæ of the tongue, especially of the tip and edges, giving the characteristic redness. We have every degree in the intensity of these symp- toms, from the slight irritation with determination of blood, to the well developed inflammation. With these evidences of disease, the mind at once turns to those remedies which allay irritation-Hydro- cyanic Acid, Peach Bark, minute doses of Aconite, Ipecac, Rhubarb, Bismuth, Oxide of Zinc, and some of the simpler stomachic bitters, as the Hydrastis. If we have the general indications for a group of medicines, we will find it much easier to select the special one which will be most efficient. The reader will notice 270 STUDY OF DIAGNOSIS. that these remedies are alike applicable in all cases characterized by irritation and determination of blood, even in cases of severe structural disease. The evidences of atony are impaired circulation and innervation, and want or perversion of function from. this, is found in sensations of weight and fullness in the epigastric region, a sense of oppression referred- by the patient to the epigastric region. When we ex- amine the patient we find that the expression of the face is dull, the movements listless and show a want of energy. If we examine the tongue we find it full, and expressionless, in some cases pitting where it comes in contact with the teeth. As a rule there is increased secretion of mucus, and the bowels are constipated. The symptoms above named point the physician to that class of remedies which are topical excitants to the stomach, and that stimulate a better circulation and innervation. Nux Vomica and Strychnine may be taken as the type of such stimulants, and are fre- quently employed when the impairment is temporary. The bitter tonics-stomachic tonics-are the remedies usually selected when the impairment is of longer dura- tion; Hydrastis Canadensis, Gentian, Columbo, etc., may be taken as examples of this class. With atony there may be irritability, and in such cases the remedies might be Amygdalus Persica, or Matricaria Chamo- milla. If the atony is very marked we may employ topical stimulants, as White Mustard, the peppers, or combine with the stomachic bitter small portions of Podophyllin. - Atony with increased mucous secretion will be marked by the coated tongue, yellowish or gray, especially toward the base, full and expressionless features, dull eyes, and evidence of oppression. STUDY OF DIAGNOSIS. 271 I In acute disease it may call for an emetic, may be relieved by a cathartic carefully given, by the use of saline diuretics, or by the use of the Alkaline Sul- phites. Excess of gastric juice will usually be known by its eructation, the sense of acidity of stomach, elongated papillæ of the tongue tipped with white, and mal- digestion. For it we think of remedies that allay irritation, or that remove diseases of which this is sympathetic, as of Bismuth, powdered Charcoal, the Alkalies, or the Acids, as may be indicated by other symptoms. Deficiency of gastric juice is shown by mal-digestion and eructations of undigested food for some hours after eating. It may require stimulants, tonics, acids, alkalies, Podophyllin, etc. Recognizing the deficiency, the mind is directed to the cause, and when determined. the treatment will be very direct and certain. Excess of acid is determined by the eructations, and the sense of acidity, but if of the blood as well it will be shown in pallor of mucous membranes. Whilst the alkalies would seem to be the direct rem- edies in the treatment of these cases, they are really curative only where there is evidence of this lesion of the blood. In other cases the cause must be determined. Many times it is a wrong of innervation, and wher this is removed, the acidity ceases. In some cases, in- deed, acids have a more direct influence in effecting a cure than the use of alkalies. Deficiency of acid may be known by the unpleasant fluid eructations, greasy if fatty matter is taken as food. The general defect will be shown in the deep 272 STUDY OF DIAGNOSIS. } redness of mucous membranes, and wherever blood comes to the surface. This is sometimes the cause of serious functional wrong, and until the acid is restored digestion will not be well performed. In these cases we usually think of Muriatic Acid as the remedy, though in many Lactic Acid will give the best resuits. The symptoms pointing to Pepsin as a remedy are not very direct. Indeed if we should say there was an entire absence of symptoms it would be a better guide to the physician. Given a case in which there. is indigestion or enfeebled digestion, and there are neither evidences of irritation nor atony, acidity nor alkalinity, or wrongs of innervation, or disease of which this may be sympathetic, and we would say, give Pepsin. The wrongs of intestinal digestion require care in diag- nosis, as many of the symptoms are obsure and indirect. The lesions may be classified as in case of the stomach, into irritative and atonic, and the sensations of the patient, if they are described, will usually lead to a correct conclusion. The pinched expression of facé, the loss of adipose tissue, giving a shrunken appear- ance of body, the contracted tongue, slick, seemingly divested of papillæ, tell the story of irritation. The atony will be indicated by fullness of the abdomen, with a sense of atony as the hand is passed over it; the full, doughy tongue, inclined to be coated, and the gen- eral oppression of the nervous system, give very clear intimations of the character of the lesion. The irritative condition cails for Aconite, Ipecac, Matricaria, Amygdalus, Bismuth, the stomachic bitters, Epilobium, etc., and they may usually be selected with STUDY OF DIAGNOSIS. 273 considerable certainty. The atony calls for Nux Vomica, Chelidonium, Podophyllin, etc. In many of these cases the combination of Podophyllin in minute doses with one of the simpler bitters, answers an ex- cellent purpose. As a rule good blood-making follows good digestion and having secured the one we are not troubled to look after the other, yet sometimes we have the fault here and must rectify it. Good blood-making is de- pendent upon the conditions already named. There must be a normal temperature, a normal circulation, normal activity in use, normal waste and normal ex cretion. If there is a wrong of either factor we may expect some degree of wrong in the making of blood, and in nutrition. If at any time we suspect this lesion we examine our patient thoroughly with refer- ence to these important functions, and finding the wrong, whatever it may be, we right it. There may be a want of some particular material in order to make good blood and good tissue. This has been recognized by physicians, and is the basis of that called restorative medication. We have already scen that the physician must select the proper food for his patients, and that more may depend upon giving his- togenetic or calorifacient food, than upon medicine. "Restorative medication" is an indefinite term, as used, and may mean remedies that stimulate an appe- tite, increase digestion, giving of proper food, as well as the use of those agents which add a needed constitu- ent to the blood. It would be better to restrict the term to the use of agents that enter into the formation of the blood and the tissues. We may sum these up as Iron, Phosphorus, Soda, Lime, Potash, Sulphur, Silica, F 274 STUDY OF DIAGNOSIS. 1 Copper, and the bitter principle. These may not be all, but if we can get a clear conception of their use, the wrongs that follow their defect, and the symptoms that point them out, we will do well. As Iron is the coloring material of the blood, want of color is generally regarded as indicating the use of this remedy as a restorative. In some cases the evi- dence is sufficiently clear, and when Iron is given the effect is direct and positive. If taking the symptoms, “want of color from blood,” we are careful in our ex- amination to exclude those cases where other and pri- mary lesions exist, the certainty would be almost abso- lute. But there is another indication quite as certain as "want of color," when tissues, especially the tongue, show a solid but not deep blue. In these the action of Iron is specific. Again we find certain lesions of the blood, more noticeably those which give an erythe- matous eruption (erysipelas), in which the redness is dirty or dulled, in which Iron is specific. When the diagnosis is carefully made, the action of Iron will give great satisfaction. A recent case of uterinc disease of long standing with greatly impaired nutrition, presented as a prominent feature frequent erythematous eruptions of this dirty, though somewhat vivid redness, and the cervix uteri and vaginal tissues presented the same color. One grain of Iron by Hydrogen three times a day, was sufficient to effect a cure in a month. In another, where there was im- paired nutrition of many years' standing, and no direct symptoms but the solid blue tongue, the patient made a quick and good recovery on Iron alone. The best indication for Phosphorus in its varied forms, will probably be found in the want of expression, STUDY OF DIAGNOSIS. 275 · both in the face and in movement, an enfeebled respi- ration and unequal temperature. The sensations of the patient may point to impaired nutrition of the nerve centres, or simply to a general failure of life. The indications for Phosphorus in the ordinary dose, are invariably of atony-impairment of the circulation and innervation. In a minute dose it may be used where there are evidences of vascular and nervous ex- citement with enfeebled tissue-as instanced in low grades of inflammation of the lungs. Soda is a true restorative in some conditions of dis- easc. If deficient in quantity every function of life is impaired, and without its restoration recovery can not take place. In some cases want of Soda is the basic lesion, and its administration all that is necessary for a cure. In others this deficiency is but one of many lesions, and the giving of Soda will be but one of the means employed. The indication for the use of Soda is clear and un- mistakable--want of color in mucous membranes which are usually full. Usually we are guided by the tongue, and the expression would be full and pallid— Soda. The indications for Lime are not so distinct, but yet quite definite. We are in the habit of saying that Lime is indicated in all idiopathic cases of suppurative disease of cellular tissue. The very fact of inflamma- tion with a low euplastic or cacoplastic deposit, not the result of injury, evidences a peculiar wrong, and for this Lime is the remedy. Furuncular disease in all its forms, finds a remedy in Lime. In the majority of cases, there will be pallor of mucous membranes, though in some cases they will be purplish or blue. Lime is 276 STUDY OF DIAGNOSIS. 1 employed in chronic disease of the lungs, with caco plastic deposit, determined by a low grade of inflamma tion. The indications for Potash will be found in pallor of mucous membranes, calling for an alkali, and impair- ment of muscular power. In most cases a dull, leaden hue of mucous membrane with pallor, will point espe cially to the Salts of Potash. A marked example will be found in syphilis, in which this coloration is the in- dication for Iodide of Potassium. In some cases a Salt of Potash may be needed, even though the deep color- ation calls for an acid; this is sometimes seen in scurvy. Here the Soda is excess, Potash is defect, and the patient is cured by the administration of Lemon juice and vegetables containing Potash in large quantity. The best indication for Sulphur as a restorative is a change in or want of the pigment of the skin and hair. In some cases the dull, dirty color may call for Sulphur, in others the blanched surface. Rapid loss of color in the hair will sometimes be an indication. Sulphur is also indicated by a peculiar blue or leaden color of urine and fæces. It would be designated by some, "want of color," and so there is a marked lack of the natural coloring material of these excretions. If I were picking a case to obtain the most marked curative action of this drug, I would take the dirty or tawny skin with bluish urine. The indication for Silica is not very well known. I have used it with most advantage when the epithe- lium had a lifeless appearance, and there was continued tendency to desquamation. In some cases these symp- toms are followed by severe ulceration of the skin. Hahnemanr. claimed that it was a valuable remedy in STUDY OF DIAGNOSIS. 277 rachitis of children, and named sweating of the head, as one of its most prominent indications. Copper is not usually regarded as a constituent of the body, yet I think it is clearly proven that it is present in small quantity. The indication for its use is the unpleasant greenish pallor of skin met with in some diseases of women, and a very similar coloration of tongue. In some cases the patient has not lost flesh, and nutrition seems to be quite as good as usual, but there is a want of energy and power of endurance. The Bitter Tonics are in such common use, that it would seem hardly necessary to point out the indica- tions for their use. But one would find it a little diffi- cult to point out clearly the cases in which the bitters are direct remedies. One might say "want of appe- tite," and as by their topical action they are appetizers, he would guess his case off right with the majority. Or we may say "impaired digestion," and by their topical action they do improve digestion, and we would be right in the majority. Or we might say "enfeebled nutrition," and as they do improve nutrition, we would make a right diagnosis in a great many cases. The blood requires a bitter principle, and its want is the cause of most serious disease, yet I can not point the reader to any better evidence of it than impaired appetite, digestion and nutrition. Further along, we will see that a right circulation is essential to carry the blood, thus well made, to the tis- sues where it is to be used. Wrongs of the circulation impair the quality of the blood, and the power of the tissues to withdraw from it the materials for nutrition. Thus in all cases of lesion of nutrition a right circula- tion must be maintained. In this connection attention 278 STUDY OF DIAGNOSIS. may also be called to the necessity of having the normal temperature of 98°, which, as we have already seen, is a condition of healthy life. A patient may have good food, good digestion, and good blood-making, and yet there will be a failure in nutrition. If the tissues are not in a condition to ap- propriate the material and weave it into organic forms, the patient would be better not to take it as food. We have already referred briefly to the properties of form- ative cells, and have seen that we have no means of determining their condition, except by the physical properties of the tissues en masse. If they have normal hardness, elasticity, form, and activity, we have reason to conclude that nutrition is good, in so far as the power of appropriation is concerned. Conversely we may say, if they want hardness, elasticity, form, and activity, there is a want of power to organize new tissue. Diagnosis is here made by the tactile and visual senses, and will be valuable just in proportion as these have been trained to use. Concluding from these evidences that the tissues lack the power of appropriation, what will be the remedies? In so far as internal remedies are con- cerned, we have but few that influence the furction of the formative cells. To a limited extent, some of the bitters may do this. Yet when we subtract their topi- cal influence upon the digestive apparatus in increasing the appetite and improving digestion, and the slight stimulant influence upon the circulation and innerva- tion, there is but a small fraction to be accounted for. Want of hardness, elasticity and activity will show a want of nutrition, whilst the change in form, want of expression-dull and lifeless-may be taken as evi- STUDY OF DIAGNOSIS. 279 1 dences of a want of retrograde metamorphosis. We have already made reference to the great law of animal life-as an organism is used it gains the power of re- production and increased use; as it is disused it loses this power. But it is well not to forget that over-use will impair reproduction, the forces of life being thus exhausted. In many cases, after providing for good food, good digestion, and good blood-making, a good circulation, normal temperature, and good innervation, we stimulate the appropriation of material by the tis- sues by well regulated exercise. Or if the patient is over-worked, and thus exhausts his powers of repro duction, by recommending rest. In some cases the patient requires exercise under the influence of the will, innervation in this way being of as much importance as the activity of tissue. In other cases it requires passive movement, with as little expenditure of nervous power as is possible. In some cases the stimulus of electricity becomes an important means, and by its general use normal nutrition of tis- sues may be obtained. The character of deposits may usually be determined by the symptoms indicating the condition of the gen- cral health, and by the local appearance of the part when near the surface. Bearing in mind that good blood will give euplastic deposits, an inferior blood cacoplastic deposits, and a very poor blood aplastic deposits, we will be in a pretty good position to judge. The means of determining this have already been pointed out. As regards the local symptoms we may say that the inflammatory process, regular in its course, is the best evidence of euplastic deposit. All irregularities, 280 STUDY OF DIAGNOSIS. whether of time, intensity, or of the common symptoms -heat, pain, redness or swelling-point to a deposit of lower character. So certain is this that the physician will very rarely make a mistake if irregularities cause him to employ greater vigilance. If for instance, in local disease, there is too much or too little heat, too much or too little pain, too much or too little swelling, too much or too little redness, or if the color is changed, we are sure the deposit, if there is one, will be low in character. So if the disease runs its course too rapidly, or progresses too slowly, we conclude that the deposit will be of lower grade. So true is this, that we look with suspicion on all alterations of the inflammatory process, and use extreme care in the treatment of such cases. Degeneration is not easily recognized, and in a major- ity of cases it progresses until the destruction is beyond remedy. Of course I exclude granular degenerations of the kidneys (known by albumen in the urine), and degeneration of the liver (known by jaundice), which present characteristic functional disturbance. The gradually decreasing power of continued exertion is an important point in the diagnosis. Persons having de- generation will find themselves incapable of prolonged exertion. There is a want of expression in every part, and the soft tissues sit upon the bones like an ill-fitting suit of clothes. A want of sharpness and strength in the wave of blood as it passes under the finger is an additional element. In the treatment of degenerations we wish to re- establish this" renewal of life." Whilst we want good food, good digestion and blood-making, adding any agents of the class restorative that may be needed, and STUDY OF DIAGNOSIS. 281 an active condition of the formative cells, we also want increased retrograde metamorphosis to remove the old and degenerated tissue. In so far as the tissue is de- generated it can never be replaced, but it is possible to so improve the function of nutrition, that what yet re- mains may serve the purpose of the organism. The diagnosis of growths belongs to the province of surgery, and requires but a brief notice here. They are classified as benign and malignant, and to deter- mine to which of these two classes a growth belongs is the first object. As a general rule we may say a benign is a growth from the tissues, whilst a malignant is a growth in. A benign growth is distinctly separate from the tissues, and though it may be deeply seated it obtains room for its enlargement by separating them, and occupying the place of the connective tissue. It may interfere with the nutrition and use of tissue by pressure and weight, and in rare cases when inflamma- tory action is set up may form adhesions to them, other- wise it maintains a distinct and separate existence. On the contrary, a malignant growth takes possession of the tissues of the body, and grows in them, trans- ferring the structure into its own lowered forms. It is no respecter of tissue, and occupies one quite as readily as another, taking possession alike of skin, connective cellular tissue, muscle and bones, using the fibrous tissue as its skeleton, and the blood-vessels, lymphatics and nerves, for its supply, waste and innervation. The reader will notice that if in any case it be pos sible to determine the condition of a growth-from or in—the diagnosis is readily made. A growth that does not interfere with or take possession of tissue, is of necessity benign, whilst a growth that does appropriate 24 282 STUDY OF DIAGNOSIS. the normal tissues is as surely malignant. In a major- ity of cases careful inspection of the part will deter- mine this. A benign growth is generally of uniform consistence, smooth, and of equal elasticity as the hand is passed over it. The reader will readily see why this should be the case, as it has a single point of origin and supply, and consequently a uniform development. But in the case of a malignant growth, its consistence and elasticity will depend to a considerable extent upon the. tissues it appropriates, and hence it will be of unequal hardness and elasticity-nodulated. There is a marked difference in the sensations of the part. The benign growth has no nerves, and any sen- sation experienced will be from its pressure or drag- ging upon adjacent parts. The malignant growth appropriates the nerves of the part, and hence inter- stitial pain of a peculiar character is usually found in these cases. A benign growth has no lymphatics, and does not influence the blood other than by withdrawing the materials for its supply. On the contrary, the malig- nant growth appropriates the lymphatics as it does other tissue, and furnishes through them a cancerous lymph which eventually produces the constitutional impairment so generally noticed. SECRETION. Among the important functions changed by disease. secretion holds a first place, and in the practice of medicine remedies influencing the secretions have held STUDY OF DIAGNOSIS. 283. a first place. But very crude ideas of the function of secretion have been held, and of course the medication based upon these was equally crude and empirical Whilst physiologists have been pretty clear in their teaching that (in the main) secretion was purely a vital function performed through certain cells, called secre- tory, physicians have acted as though they believed it a purely physical process, like the osmose that occurs through an animal membrane. If secretion is a vital process, life is an essential, and the conditions of life necessary; if it is a physical process of straining, then a dead tissue may secrete as well as a living one. There is little use to talk of diagnosis here, unless we have first a clear idea of the apparatus of, and the conditions for secretion. If we can clearly appreciate that in the case of all the secretions-recrementitious and excrementitious-there must be a membrane con- tinuously giving birth to secreting cells, and that these grow to the normal stature of cells, withdraw from the current of blood the special material of their secre- tion, and then discharge themselves with it in the com- mon duct, we will have a basis for correct diagnosis and therapeutics. Taking one step further, we find that function not only depends upon life, but upon the normal conditions of life. This is true of every part and every function of the body. Studying the life of cells, and secreting cells bear a very close relationship to formative, we find that a certain temperature, circulation and innervation are necessary. Probably the life of the secreting cell. *These conditions are. as necessary to the entire organism as to the individual cell, otherwise we would not be benefited by 284 STUDY OF DIAGNOSIS. is not so much affected by changes of these, as the life of the formative cell, but in a certain range it is so de- pendent; whilst the range is greater the effect beyond certain points is just the same. The cause of lesions of secretion may be general or local, and the diagnosis is made by an analysis of gen- eral symptoms influencing secretion at large, and symptoms pointing to local lesion of the secreting organs. When secretion in general is affected, we have good reason to think that the lesion is general; when but a single secretion is affected we have good reason to believe that the lesion is of the organ furnishing the secretion. When all the secretions are involved, the cause, as a rule, will be found in changes of temperature, circula- tion, innervation, digestion, blood-making and waste. knowing them. We have constant cognizance of the gross form, while the minute structure is beyond our vision only as we bring the microscope to bear upon it. Let us now see how they are applicable to the body as a whole. First.-An original viability is seen to be an imperative condi- tion. A want of this gives us hereditary diseases and early death. A want of it also gives us an enfeebled life and a want of resisting power to the ordinary causes of disease; while a strong viability gives great resisting power to disease, and long life. This has already had a partial consideration. Second.-A proper supply of nutrient material is also an abso- lute condition, as man only lives by a constant renewal of his body. The material for this renewal being furnished, and the cells possessing a normal formative power, life continues in a regular manner. Third.-The circumstances favorible for normal development in man are a normal circulation, innervation, temperature, and excretion.—Principles of Medicine. STUDY OF DIAGNOSIS. 285 If now secretion is to be restored to its normal condi- tion, we want normal temperature, normal circulation, innervation and waste, especially the first three. In a large majority of cases, secretion is re-established so soon as the conditions of life permit, without the use of special means to this end. Thus in acute disease, if means are employed to rectify the wrongs of circula- tion, the temperature and innervation, we find that the tendency is to a re establishment of secretion as the conditions of health are approached. Local lesions of the secretory apparatus are best classified as irritative and atonic, as it points out the classes from which our remedies are to be drawn. When a part is involved there will be in nearly all cases such unpleasantness of it as will call the attention. of patient and physician to the wrong. It may be pain, or something less pronounced than pain, but i. gives the special part a distinctive character separate - from the general life. In health the body is a unit, and all sensations are pleasurable, in local disease there is a feeling of separateness between the part and the life, and the severer the disease (as a rule) the more distinct this feeling which regards the suffering part as distinct from the life-a foreign body, which it would be well to get rid of. It is true these subjective sensations are not always pronounced, and in some cases the suffering is so mani- fested that it seems of some other and distant part. Yet if the patient's attention is excited, he readily de- termines the wrong sensation, and our knowledge of nervous distribution and sympathies will soon translate the character and situation of pain. The reader will already have been impressed with 286 STUDY OF DIAGNOSIS. | 1 1 the character of pain as determining the condition of a part as regards excitation and atony. Excluding neuralgia, acute sharp pain is the evidence of undue excitation and an active condition, whilst dull pain and ` sensations of weight and fullness, indicate atony, with impaired circulation and innervation. It may be said that this method of diagnosis is too gross and arbi- trary, but I think in the majority of cases it will serve as a good basis for the selection of remedies. With this method, we should say the absence of local symptoms points to general disease, and we carefully examine our patient with reference to the conditions of normal secretion. Finding the wrong in tempera- ture, circulation, or innervation, we select from those remedies that influence the particular function, and take that one which in its action is opposed to the dis- ease, and in its influence brings the functional wrong toward the standard of health. Determining a local wrong, we at once think of those remedies that espe- cially influence the organ or part, and take that one which in its action will do that which favors the healthy life of the part. Nothing can be simpler than this în theory, as nothing, I am sure, will furnish a better basis for a successful practice of medicine. Secretion is divided into two classes, recrementitious and excrementitious, and it is well for the reader to have a good knowledge of these distinct from each other, learning the uses of each. We want to know the simple facts, with regard to the use of saliva, gas- tric juice, bile, pancreatic fluid, and the small glandulæ of the intestine in digestion, that we may weigh the wrongs which may arise from changes in these secre- tions. We want to know the value of mucus as a STUDY OF DIAGNOSIS. 287 lubricant and protector of mucous membranes, and of the sebaceous secretions as a lubricant and protector of the skin. And we want to know the value of excre- tion from the lungs, the kidneys, skin, and bowels, as a means of removing worn out and effete material from the body. It is direct thought that we want, for when the mind is directed to a single object it readily grasps. it, but when it is made to embrace a multitude of objects, they become indefinite and indistinct. If, for example, we are called to a case of increased secretion of saliva the diagnosis is easily made, for the senses can not fail to be impressed by the increased amount of fluid in the mouth. But the questions that follow are not so easily answered-is it mercurial from local disease of the salivary glands? from disease of parts contiguous? from diseases of the digestive apparatus below? from disease of the brain? or from a lesion of the sympathetic system of nerves? It seems difficult at first to make such diagnosis, and yet as the mind considers one after the other of these, with such light as additional symptoms may throw on it, the problem is soon solved, and in its solution we are directed to the particular class from which the remedy is to be selected, and possibly the special remedy which will cure. The example given above is one of the most com- plex, and we will find the others simpler. If we take the secretion of gastric juice we might make a different study. First, is the disease general, local, or sympa- thetic? If the examination is carefully conducted, the absence of evidence of local disease, and of parts with which the stomach is in special sympathy, and the evi- dences of general lesions which might affect the 1 288 STUDY OF DIAGNOSIS. stomach, will determine the first classification. But if the local symptoms were pronounced, and there was wanting the evidences of general or sympathetic dis- ease we would have determined the second classifica- tion. Whilst if we had pronounced disease of parts. with which the stomach sympathizes, as of the uterus or brain, but without marked symptoms of local or general disease, we would have determined the third classification. It may be that we will find two, or pos- sibly three of those causes in some cases, but we reach our conclusions by these methods of examination and thought. If we take the liver as the next example, we will find it necessary to employ a different method. The first questions we ask are with reference to local disease. Has the patient unusual sensations in the right hypo- chondrium, of pain, weight, distension, pressure up- wards on lungs, toward the mesial line on the stomach? is there tenderness on pressure, sense of fullness when the hand is passed over the part, or can the organ be felt below the margin of the ribs? Is there expression of disease from adjacent parts, as from the bowels, stomach, lungs? Is there a wrong in the uses for which the bile is secreted? It is always well to get rid of old-time errors, and in these methods of diagnosis we wish to start with a right physiology. What is the use of bile? Your physiologist will tell you, possibly, that he does not know, but he is sure that it is not, as was formerly thought, an excretion, but that it is elaborated to serve uses in digestion and blood-making. As you read on, and think of what you are reading, you see the absur dity of the old practice of medicine, which was con- STUDY OF DIAGNOSIS. 289 tinuously looking after the liver and the secretion of bile, and talked glibly of liver complaint, liver disease, "your liver is affected," and about liver pills, chola- gogues, "touching the liver," etc. It requires but little study to get rid of this old rubbish, and reach the conclusion that the liver does its work very kindly and well, and is an organ that aids nutrition, and not waste. If, therefore, we find a wrong of intestinal digestion, in which the liver is very surely concerned, we may look after the condition of this organ. The secretion is peculiar in color, and sometimes wrongs of the liver may be determined by this. Thus fæcal matter is to some extent colored with biliverdin, and if the color is dark we say, excess of bile—if it is light we say deficiency of bile. This method of diag nosis is a little crude, for there are many sources of error. Thus Lehman showed that the peculiar green stools following the administration of Calomel were not due to any action of that drug upon the liver, but to the presence of Sulphate of Mercury in the fæces. An excess of acid may also produce green stools, as a de- ficiency may render them lighter in color. The cutaneous pigment will prove a better guide than the color of the fæces. The yellowness of jaun- dice will be called to mind as an instance, and many will recollect brownish spots-liver macula-that are very clearly traceable to the liver and its associate organs. But a change in the pigment less marked than this has a very definite meaning. I allude to a taumy coloration of the skin, giving it a dull, dirty appear- ance. I believe this always points to a wrong of the chylopoietic viscera, especially to innervation from the 25 290 STUDY OF DIAGNOSIS. ! solar plexus, and indicates the class of remedies that have been regarded as "liver medicines." But the really important point to determine in these cases is, the condition of the organ with regard to ex- cess or defect, in its circulation and innervation-is there excitation or atony? The symptoms are usually distinct so far as this is concerned, and the remedies. will be clearly pointed out. And yet there is nothing in which mistakes are so frequently made. Take, for in- stance, a case of jaundice, and the teaching of the books, is to give hepatic stimulants-Podophyllin, Leptandrin, Blue Pill, Calomel, etc., without reference to the condi- tion of the liver. But in one-half the cases, there are evidences of excitation in pain, tenderness on pressure, and accelerated circulation, increased temperature, dry skin and scanty urine. Surely hepatic stimulants are not remedies here, and they usually do much barm in- stead of good. In such case the patient requires the special sedatives, Gelseminum, Acetate of Potash, the bath, and possibly the cold-pack or fomentations to the right hypochondrium. In the opposite class of cases, with sensations of weight, fullness, oppression, unequal temperature, etc., such remedies as will stimulate the liver and associate organs will prove remedies. Again we wish to know in this connection that the bile pigment when once deposited in the cutaneous tissues is never removed by way of the liver, but is always excreted in principal part by the kidneys. In so far then as getting rid of the unpleasant coloration of skin in jaundice is concerned, we might just as well give a remedy to act upon the salivary glands as the liver. There are scores of these olden-time errors in STUDY OF DIAGNOSIS. 291 practice that can only be gotten rid of by a carefu' study of physiology. The pancreas does a most important work in secretion, one which the physiologist clearly understands, and yet we hear nothing about "pancreatic complaint," "pan- creatic disease," or "touching the pancreas." Indeed there are no pancreatic remedies in our Materia Medica. Why is this? There is nothing like getting these sub- jects fairly in view, that we may think of them. Leh- man remarks" The function of the pancreatic fluid in digestion, may be two-fold, according to the above men- tioned properties, namely: to change starch into sugar, and to decompose the fats, so as to render them absorb- able. That it actually performs the former in diges- tion, has been placed beyond doubt by numerous ex- periments. The pancreatic fluid possesses this property in a much higher degree than the saliva; it is opera- tive at even a low temperature; neither bile, nor gas- tric juice, nor free acids, interfere with the function of the fluid." What then would be symptoms of disease of the pan- creatic secretion? Most surely they would be func- tional, and we would find them in imperfect digestion of calorifacient foods, a deficient supply of burning material, and a more or less rapid consumption of the fat stowed in the body. We would naturally expect te find unchanged starch and fat globules in the fæces, and examination shows that this is the case. Just so soon as we begin to reason rightly, we reach definite results. But if we have no "pancreatic medicines," how will we rectify these wrongs, after we have found them? This is also easy enough. There are in almost all cases 292 STUDY OF DIAGNOSIS. • certain general lesions of the circulation, temperature, innervation, excretion, etc., easily recognized, and which must be relieved in all cases preparatory to a successful local treatment. As local remedies we may think of Veratrum, Cactus, Chelidonium, Oxide of Zinc, Nux Vomica, Podophyllum, Iodine in minute doses, Panax, etc. They all act "there or thereabouts," and we can choose from the list those that act in the right direction. To the doctor in ordinary, the intestinal canal is a place to put pills, powders and potions, for purgation. Bowels were made to be moved, and it is the doctor's business to move them, and sometimes, it seems, it is almost his whole business. He never thinks that the intestinal canal is a digestive apparatus, and if he has ever learned this in his physiology he has forgotten it. And yet this function of the intestinal canal is really the most important element in digestion. "" In addition to the bile and pancreatic fluid, we have an intestinal fluid secreted by the "bottle-shaped glands of the alimentary canal. With regard to this · Lehman remarks-" The intestinal fluid serves, as re- gards its function, as a complement to the digestive fluids, the gastric and pancreatic fluids, which become inoperative toward the middle of the small intestine; it possesses not only, as the latter of these does, the power of rapidly changing starch into grape sugar, but also of dissolving and rendering absorbable flesh and other protein bodies. In tied knuckles of intes- tine, into which starch or paste has been introduced, all the starch is transformed into sugar at the end of three hours, and in a great measure absorbed. Pieces of meat or coagulated albumen disappear from such knuckles after six to fourteen hours." STUDY OF DIAGNOSIS. 293 This is good reading, my friend of many cathartics, and it is well to give it a prayerful consideration. Here is a fluid that will do the entire work of digestion, and here is an apparatus that really does do a considerable part of it. When you have occasion to use the old- fashioned harsh remedies, think twice, and possibly you may see that the wrong done to this important function may outweigh, many times, the good that comes from counter-irritation. The remedies named above, for wrongs of the pan- creatic secretion, may be employed here, with some additional ones. What we want to know, as a basis for a rational prescription is-do we want sedation or stimulation-do we want it of the circulation, or the innervation, though these are usually associated. It is hardly worth while to point out now the special indi- cations for Amygdalus, Bismuth, Nux, Chelidonium. Aconite, Ipecac, Nitric Acid, Podophyllin, etc., for their uses will have been learned elsewhere. Mucus is secreted to lubricate and protect mucous surfaces, and in normal amount it favors the perform- ance of function. Wrongs of the secretion are usually easily determined. If of the outlets of the body, the condition may be seen and felt. Thus it is easy to re- cognize increased secretion from the nose, throat, and genito-urinary passages, from the abundant discharge. Increased secretion from the bronchial mucous mem- branes is known by its discharge, and also by the blow- ing and rattling sounds heard during cough and on auscultation. Increased secretion of mucus in the stomach is usually shown by the heavily loaded tongue at its base. Whilst increased secretion of mucus in the intestinal canal will be shown by the uniformly dirty 294 STUDY OF DIAGNOSIS. tongue, and by the tumid abdomen. Scanty secretion gives rise to irritation, and this is one of the prominent. signs, and taken together with the absence of discharge is very good evidence. With a wrong of mucous secretion we ask the ques- tions-what are the general wrongs, operative in this case? what is the condition of the mucous membrane, as regards its circulation and innervation? It is a rule in practice, to rectify any general lesions, prepara- tory to the cure of local disease, and many times with this the local disease will disappear. Thus in a given case of acute disease, we have a frequent pulse, high temperature, and excited innervation, with dry mucous membranes; the use of the appropriate general reme- dies will establish secretion. And on the contrary, if secretion is too free, the use of appropriate general remedies will lessen it. When we think of local remedies we want to group, a, those which act upon mucous membranes; b, those that act upon the special organ, part, or function in- volved. Having the classes of remedies before us, we now select a stimulant, sedative, or one which by its action tends to change the character of the secretion or function. It is not difficult to select a local remedy if we know exactly what needs be done, and we have a clear knowledge of the value of remedies. A change in the sebaceous secretion frequently gives rise to cutaneous disease. If our attention is directed to the function of this secretion, as a lubricant of the skin, its lesions will readily be detected. The treat- ment here will have reference to the condition of exci- tation or atony of the circulation and innervation, and to changes in the nutrition of the organ. Sedatives in STUDY OF DIAGNOSIS. 295 i the one case, stimulants and tonics in another, and remedies that alter morbid action in others, will be selected to meet the different cases. A wrong in the secretion of tears, or the meibomian secretion, may occasion serious trouble with the eye. Profuse lachrymal secretion is sometimes a source of irritation, always a source of feebleness to the tissues. Scanty secretion on the contrary, by leaving the eye dry, and without the protection given by this fluid, is a cause of irritation. The secretion of the meibomian glands serve an important purpose, and when in excess or defect, the function of the eye is impaired, and un- pleasant disease may be grown. Just so soon as the mind is directed to the parts which may be diseased, it is pretty certain by direct symptoms or by exclusion, to determine the exact loca tion and kind of disease. Then knowing the action of remedies, local and general, these may be selected with reasonable certainty. A wrong in the secretion of cerumen is a very fre- quent cause of partial deafness, and many aural un- pleasantnesses. It is surely well to know this, and by a careful examination determine the character of the disease-whether in excess, defect or perversion-and also the condition of the secreting structures as it re- gards increased excitation or atony. With such knowl- edge as may be readily obtained by any one, the treat ment of these diseases becomes successful. The principal object in the consideration of these secretions is to call attention to the necessity of con- stantly keeping our physiological knowledge well in hand, and directing attention first to the use, that we may be able to understand the disease. If at any 296 STUDY OF DIAGNOSIS. time we forget this, and take the ordinary writers on pathology and therapeutics as authority, we are quite sure to go astray. The excrementitious secretions are four in number—the lungs, the skin, the kidneys and the bowels-and these remove the waste of the body. The due performance of the function of excretion is essential to health, and in disease we invariably find a lesion of one or more. If the excretions are in excess, debility is the result, and becomes a prominent symptom. If they are in defect, materials which should be removed, are re- tained within the body; the result being irritation or oppression, according to the character of the material, and the amount retained. Excretion by the lungs is but little studied, and yet this is one of the most important of the excretions, being to the extent of 517 grains of carbonic acid per hour. In a rough estimate the value of these excretions may be written-lungs eight, kidneys two, skin and bowels each one. True it is carbon which is thus ex- creted by the lungs, (this being regarded in the olden- time as the special province of the liver), but a simple experiment in closing the mouth and nose of an animal will show that it will kill in a very few moments. Excretion by the lungs may be in excess, and this will be seen by the vivid redness of the blood where it reaches the surface, by the frequent full respirations, an exalted circulation, an excited nervous system, a high range of temperature, and rapid waste of tissues. We find these evidences of excess both in acute and chronic disease, and it must be evident to the reader that means to check it will be of value in both cases. Such a remedy as Veratrum, and to a less extent STUDY OF DIAGNOSIS. 297 } Lycopus, Cactus, Sticta, must prove of great value in such cases, associated with such local and topical ap- plications as relieve irritation and give rest. The reader will see very clearly that in the early stage of pneumonia with such symptoms, Veratrum and a mush- jacket may prove speedily curative, and that in some cases of phthisis, Veratrum becomes a prominent remedy. Defect in excretion from the lungs will be known by the darker color of the blood where it comes to the surface, the evident defect in the movements of the chest, fullness of superficial veins, and the oppression of all the functions from retention of carbonic acid gas. At once our attention is directed to such remedies as prove excitant to this function, as Nux, if there is de- ficient spinal innervation, Phosphorus, Arsenic, Lobelia, Bryonia, Drosera, Apocynum, etc. If by these means, excretion of carbonic acid can be increased, the various functions of life are relieved from oppression. Even if this knowledge did not point us to special remedies, it would be valuable as suggesting a proper hygiene. The patient suffering from excess wants quiet and rest, a moist atmosphere, and one not stimu- lant. The patient suffering from defect requires such exertion as will call into action the respiratory appa- ratus, a dry atmosphere, and one which is stimulating. Proper direction in these regards may be the one thing. necessary to recovery, and we can only give such ad- vice when we thoroughly understand our case. The attention of physicians has been specially directed to the skin, kidneys and the bowels, as the apparatus of excretion, the importance of this function to health, and as a cause of disease. Indeed they have 298 STUDY OF DIAGNOSIS. received too much attention (such as is) for three- fourths of the Materia Medica has for its object an ac- tion on these emunctories. If we should take away from the regular physician his cathartics, diaphoretics and diuretics, he would be poor (for harm) indeed. Whilst I do not wish to depreciate these functions, either in health or disease, I think a much more care- ful study should be made of them, and that their thera- peutics should be improved. This fact should be especially learned-that in a large majority of cases wrongs of excretion are depen- dent upon changes in general conditions of life-the circulation, temperature and innervation-and that when these are corrected, the excretions resume their normal condition. Even when the function is not re- stored, very simple means are usually all that is required. Excess in secretion from the skin is readily deter- mined by its moisture to the touch, dampness of the clothing, as well as by the patient's sensations. The questions that follow are-is it from excitation, or is it a result of debility? It rarely results from excitation in disease, though once in a while from increased circu- lation to the skia, as in some cases of rheumatism, and in the so-called sweating fever, and some other anoma- lous cases, this will be found to be the case. Here the diagnosis is quite clear-the skin has an active circula- tion, is deepened in color, and the temperature is in- creased. The increased perspiration of debility is not secretion, but an exudation of water, washing away a small quantity of albuminoid materials. The condi- tion is determined by the evident relaxation and loss of tone to the touch, the pallor, and usually the want of sensitiveness. STUDY OF DIAGNOSIS. 299 cases. Evidently the treatment will be different in the two The one of excitation requires the special seda- tives, Aconite, Veratrum. Gelseminum, or special reme- dies influencing the sympathetic nervous system as the Rhus, Lycopus, etc. We want to relieve the undue ex- citation of the skin, and this accomplished the sweating ceases. In the other case an opposite treatment is re- quired. Here we select such remedies as stimulate the the skin-stimulant diaphoretics-Serpentaria, Senega, Erigeron, Erecthites, Polygonum, etc. Or stimulants to the circulation and innervation, as Belladonna, Lobelia, Ipecac, Bryonia, etc. Local means will vary just as much, in the one case being sedative, in the other stimulant. Defect in secretion may usually be known by exam- ining the skin, which in one class of cases gives the hand a sense of dryness and constriction, and in another dryness with want of elasticity and life. The symp- toms produced by retention of this excretion, are first of oppression, terminating in chill, and second of exci- tation, giving the phenomena of fever. As will be seen, the general symptoms are somewhat indefinite, for both the oppression and stimulation may be the result of other causes. It is well to give due weight to this lesion, though we may not rest our entire practice upon it. If the defect in secretion is due to an increased cir- culation and temperature, means to rectify these wrongs will stand first. In a majority of cases of fever and in- flammation, a right use of the special sedatives and proper baths will place the skin in such condition that it will resume its function; or that it can be called into action by very simple remedies. In other cases, where 300 STUDY OF DIAGNOSIS. $ the wrong of circulation, temperature and innervation is based upon other special lesions, the use of the special remedy for this, is followed by a return of normal cir- culation, temperature and secretion. A marked ex ample of this will have been seen in the administration of Tincture of Muriate of Iron in some cases of erysip- elas, as well as in the use of Rhus, when specially indicated. If the defect is due to a want of excitation in the cutaneous nerves and circulation, remedies are employed which exert a stimulant influence upon the skin. Many diaphoretics owe their power to influence this secretion to their stimulant influence, and of course they can be beneficial only when a correct diagnosis is made, and they are rightly used. Perversions of this secretion are not uncommon, but owing to our imperfect means of diagnosis are rarely recognized. "This fluid, (sweat), as it collects in drops on the skin of one perspiring, is colorless, tastes salty, has a peculiar odor, is poor in solid constituents, and, when recent, always reddens litmus." Yet we find in disease that it has color, sometimes to the extent of coloring the clothing, varying in shade and intensity; has a variety of tastes, sweet, sour, acrid; is rich in albuminoid elements; and is sometimes neutral to test paper, and in other cases will change red litmus blue. Evidently here is a field that will repay investigation. Authorities upon skin diseases have recognized the fact, that perversion of the secretion may be a cause of some of these, and may perpetuate the most intract- able. In so far as we know now treatment will be directed to the physical condition of this organ, as shown by STUDY OF DIAGNOSIS. 301 examination, and to lesions of the blood. The last are sometimes very important, for so long as there is in this fluid morbid material that is excreted by the skin, so long will the skin suffer. Before leaving this subject, I wish to call the reader's attention to the character of normal cutaneous secre- tion, and to the fact, that in so far as it is a secretion it is effected by secreting cells. In its normal state the skin has a uniform temperature slightly below that of the blood, gives to the hand a pleasant sensation of softness and elasticity, is not damp and moist, indeed rarely shows moisture upon the surface except on in- crease of temperature and exertion. As this is the condition in which it does the best work, it is the con- dition we wish to obtain in disease. Many act as if they supposed secretion from the skin necessitated the pouring out of an increased quantity of fluids upon the surface, as from the old class of sudorifics. Yet in practice we find that the soft and but slightly moist skin is the best evidence of secretion. We have already studied the urine as an index to disease and a means of diagnosis, and it will only be necessary here to notice a few of the more salient fea- tures connected with this study. Whilst the physician is aware that the secretion of urine is indispensable to life, in that it removes the largest portion of the nitro- genized waste, he finds the common means of diag- nosis so defective, that he takes it for granted that the kidneys are doing their work right, because in a very large percentage of cases, they do their work right. As a matter of form he will ask-"how is your urine?" and in the olden time he might examine a mixture of urine and fæces in the chamber utensil. If the patient 302 STUDY OF DIAGNOSIS. complained of scanty urine, it might mean something, if there was uneasiness in voiding it, there was prob- ably something wrong, and if there was arrest, very surely something must be done. But just what that something should be, was not so definite, only that it must be drawn from the class diuretics, and was usually the favorite prescription. in In this study it would be well for us first, to see why any case the urine should receive a special examina- tion, and then how this examination should be con- ducted. We take it for granted that in ordinary prac- tice examinations of urine will not be made. In acute disease retention of the elements of the urine are so clearly shown by the nervous system, that there can hardly be a failure to have our attention directed to them. The first influence is that of excita- tion-the patient becomes restless and irritable and suf- fers more than the condition of disease will account for. The second influence is of oppression-the patient be- comes dull and lethargic, and finally sinks into coma. Of course we may have cerebral excitation and coma, without any wrong of the urinary secretion, but we never fail in these cases to make diligent inquiry, and satisfy ourselves as to the source of the nervous lesions. Now scanty urine has a definite meaning, as has un- pleasant sensations in its passage, or a failure to pass it, or going further, we may make a critical exainina- tion of it, as heretofore named. I do not wish to be understood as saying that inquiries with regard to the urine need not be made unless there is nervous dis- turbance, for there can be no harm in thorough exami- nations in all directions - but I desire to impress it STUDY OF DIAGNOSIS. 303 upon the mind of the reader that these are the cases where such examination is imperative. But finding a failure upon the part of the kidneys to do their work, we are not yet ready to say-give “ diu- retics." We want to know the condition of the kid- neys as regards their circulation and innervation. Such arrest may result from irritation and determination of blood, and any excitant may so increase this as to en- tirely suppress the secretion and cause death. Or it may result from capillary congestion, which the ordi- nary diuretics would increase, and thus death might result from the use of remedies which in ordinary cases would increase secretion. The condition of the kidneys may be determined in part from the patient's sensations, and in part from a personal examination. In irritation with determina- tion of blood (active condition) the patient will have a sense of constriction in the loins with tensive or draw- ing pain, sometimes seeming to be in the spine. Some- times the sense of irritation extends to the bladder, the urethra, the testes, and even to the rectum. In irrita- tion the patient is restless, quick in his movements, the eyes are bright, the tissues around them seemingly con- tracted, the tongue small and pointed, and the pulse small, wiry, or vibratile. In congestion the patient. complains of a sense of fullness and weight in the loins, and sometimes the same sense of fullness and weight in the pelvis. The patient is dull and apathetic, the eye dull, the face expressionless, the tongue somewhat full, and the pulse lacks sharpness in the wave-op- pressed. Such diagnosis is of especial value, because it en- ables the practitioner to select his remedies with cer- 304 STUDY OF DIAGNOSIS. tainty. If we have the condition of irritation, we give Gelseminum, with or without the sedatives, as may be. indicated. If there is the condition of congestion we give Belladonna, Ergot, or Solanum, with or without Aconite as the sedative. Diuretics are not given until there is marked relief, and secretion has become more free; indeed, sometimes they will not be required at all. When we do give them, they are selected with refer- ence to the condition of the kidneys-sedative diure- tics for the condition of irritation, stimulant diuretics for that of congestion. Excess in this secretion is not of frequent occurrence, and is usually recognized without trouble. The large amount of urine in diabetes, insipidus and mellitus, at- tracts the patient's attention, and is evidence to the physician of the nature of the wrong. But there are a few other cases in which the excess is not marked in this way-the patient passing but the usual amount of urine, or possibly it is less in volume than usual. It is only when tested with the urinometer that it is found continuously of high specific gravity, and that the solids are increased from one-tenth to possibly one- fourth more, and still it does not contain sugar or albu- men. Such excess will be marked by loss of flesh and strength, and by feelings of weight and dragging in loins or pelvis. The wrong may be wholly due to a lesion of the kidneys, or principally to an excess in retrograde me- tamorphosis. This of course must be determined to give us a rational treatment. Attention is rarely called to lesions of perversion by the common examinations of the urine. Of course there are exceptional cases, as the excess of urine in STUDY Y OF 305 OF DIAGNOSIS. diabetus mellitus, and urinary irritation in some cases of deposit, in which the direct symptoms are sufficient to excite attention. In the majority, the diagnosis is made by exclusion There is an impairment of the health; object-to locate and determine the character of the lesion. And thus we give the patient a thor- ough examination, with reference to the more import- ant functions and organs. Is it of the circulation, digestion, respiration, innervation, nutrition, secretion of skin, bowels, kidneys? Thus excluding one after the other, as we find them free from disease, we at last reach the affected part. Even now we do not know the character of the lesion, and proceed by the same method to determine it Is there sugar in the urine, albumen, blood, the phosphates, or some of the rarer morbid materials? The general symptoms may point. us to the special examination, or we may be obliged to make test after test, until we determine what the real trouble is. But having learned the character of the perversion, we are not yet ready for treatment. It will not do to say, here is a remedy for all cases of diabetus mellitus, albumien blood, deposit of the triple phosphates. The examination must go a step further-to what extent is it a lesion of the kidneys, or of some other part, the blood, nervous system, or the associate secretions from lungs, skin and bowels? and still a step further, we want to know the physical condition of the kidneys, and the special character of any other wrong. The reader may say these methods are very com- plex, and it will be difficult for one to follow them out (?) I admit it, and whenever possible, should rather prescribe from a single characteristic symptom, but 26 E. 1 306 STUDY OF DIAGNOSIS. there are cases that require just such thorough analysis to give succeesful treatment. When we study excretion from the bowels, we want first to correct our physiological ideas of the value of the secretion. Physicians have made a hobby of the bowels and have ridden millions of them to untimely graves. We want to know if bowels were made to be continuously physicked? and whether good or harm is most likely to result from the common use of purga- tives? If we consult Lehman again, (a most excellent authority), we find that "The contents of the intes- tines, even after the use of tolerably simple articles of diet, consist of a mixture of undigested, indigestible, and already changed or decomposed substances, with which are mingled constituents, partly undecomposed, partly already metamorphosed, of the digestive fluids." But of a real secretion eliminated by the glandulæ of the intestine the fæces contain but a small proportion- probably less than the excretion from the skin. Excess is usually associated with frequent fluid evac- uations-diarrhoea-yet we must not take it for granted that in all cases of diarrhoea there is excess. Excessive discharges of fæces produce debility, first by the re- moval of some portions of the food, and secondly by withdrawing some of the albuminoid materials of the blood. Constipation is not to be regarded as positive evi- dence of defect in secretion from the bowels, as it is possible, and not uncommon, for constipation to exist for days, and yet excretion goes on into the bowels as before. But even constipation may be a cause of dis- ease, either from irritation produced by the debris of digestion, or by the decomposition of some of the STUDY OF DIAGNOSIS. 307 1 material, or by the generation of offensive gases, or the absorption of some of the decomposed matters. Evi- dences of irritation, or of oppression, when they can. be referred directly to inaction of the bowels, may be regarded as an indication for the simpler cathartics. The more harsh remedies of this class have usually been used for their derivative effect, and the saline hydragogue cathartics to deplete the blood-vessels of fluid. Small doses of some of the cathartics, as Podophyl- lum, Apocynum, etc., do increase the secernent function of the intestine, and at the same time improve its func- tion of digestion. The dose is less than that required. for catharsis, and the indications are sensations of full- ness, weight and atony. Perversions of the secretions of the bowels and acces- sory glands are recognized principally by changes in color and in odor, but these are not as certain as would be thought at first sight. The reasons are clear-there is so much and varied coloring material taken with the ingesta, and the odor naturally intense and foul is so readily changed by decomposition of fæcal material. Still it is well to make the fæces yield all the informa- tion possible. A few examples may be given in illustration. The vivid green discharges of childhood, acrid and irritat- ing, give information of excess of acid, and suggest the use of alkalies. The extreme yellow (chrome) of in- fantile discharges, evidence an insufficient digestion of the food, both of albuminoid material and fat, and sug- gest more care in diet, and the use of remedies that give tone to the digestive apparatus. The clay-colored evac- uations of disease tell of want of secretion from all 1 1 308 STUDY OF DIAGNOSIS the intestinal glands (liver included), of impaired power of digestion, and suggest the use of stimulants to the upper intestinal canal and associate viscera. The yellow rye-mush fæces of typhoid fever is characteristic, and calls our attention to commencing disease of Peyer's glands. The deep brown or black fæces, with greenish tinge, sometimes yeasty, is one of the most marked in- dications of the typhoid condition, and calls attention to the necessity of antiseptics. The color and physical properties of mucus, pus and blood, are readily recog nized, and either by their quantity, condition, or some local symptoms, their source may be readily detected. THE BLOOD. The study of the blood is one of much interest to the physician, for in changes of its structure and circa- lation we find a principal element in many diseases. The old Hebrew poet well remarked that—" the blood is the life of the man," at least we find by experience that wrongs of the blood are manifested by impairment of the life. We study both the lesions of the blood and the lesions of its circulation, and it is well to keep them separate in the mind. Excess in the amount of blood is of very rare occur- rence as a cause of disease, and yet occasionally we meet with cases in which, from local disease, the high stimulus of a large amount of rich blood is injurious. We find such cases in local disease of the kidneys, the lungs, the heart, the brain, in which these organs, en- feebled by disease, can not bear the strain of such vig orous life. This has been named sthenic plethora : STUDY OF DIAGNOSIS. 309 ! There is another condition in which a large amount of blood is continuously made, but owing to exhaustion of the circulatory apparatus and nervous system by ex- cesses, its circulation is sluggish. Excess of blood is readily recognized by the fullness of the blood vessels, especially of the capillary system of the surface, which shows the deep tint of abundant red globules, by the full firm tissues, and the vigorous performance of function. Asthenic plethora will be recognized by fullness of blood vessels, oppression in the stroke of the pulse, and a turgid venous circulation, giving the surface the peculiar color of venous blood. The color is so characteristic, that when associated with the full animalized tissues, and the full blood vessels, there can be no mistake in the diagnosis. When high stimulus is likely to be a source of danger, we take measures to lessen the quantity of the blood. The safest means is to diminish the supply of food to a minimum, and select such vegetables and fruits as yield small proportions of nitrogenized material. In some cases the saline purgatives and diuretics may be em- ployed to a limited extent with advantage, which, with well regulated exercise, will remove the source of danger. Many a man has lost his life because his digestive and blood-making organs were so much better than the remainder of his body, that they have furnished the material for a too active life. In asthenic plethora the important remedy is right living. Cut off the supply of stimulant drinks and food, establish good excretion, and have the patient take such exercise as will promote a more rapid combustion and waste of effete material, and in a few months the patient will be on safe ground. } 310 STUDY OF DIAGNOSIS. 髀 ​7 Defect in the quantity of the blood-anaemia-is readily recognized by the want of color of surface, and the loss of that hardness and elasticity of tissue that we call tone, and a loss of size and functional activity of the soft structures of the body. "As the life of the man is his blood," we have a loss of life in proportion to the condition of anæmia. But we may have gone so far in our diagnosis as to determine absolutely that there is a want of blood, and yet not be ready to make a prescription. It will not do to say, give Iron, or give " Bitter Tonics and Iron.” We want to know why a sufficient amount of blood is not made, or why, if made, it is not applied to its proper use-nutrition. In one case it will be a want of proper food, or of some special element of the blood, in another a want of buccal, gastric or intestinal digestion, in another a wrong in the blood-making organs, in an- other a lesion of the circulation, in another a lesion of innervation, in another a lesion of retrograde meta- morphosis or excretion. Is it too much to ask that each of these receive due consideration, and that our prescription should be directed to the special fault? It requires a little time to pass all this in review, but the mind works very rapidly, and taught to work right, it will do all of this automatically. Of course the treatment of anæmia must vary in different cases, as the cause of it varies so much. In one case good food, well prepared, is all sufficient; in another some special element of blood needs to be added as Iron, Phosphorus, Soda, Potash, etc.; in an- other the digestive apparatus requires stimulation; in another special stimulants are required to increase sym- pathetic innervation; in another special means to give I STUDY OF DIAGNOSIS. 311 { a right circulation and temperature; in another stimu- lants to the formative cells by remedies and exercise; and in others still the cure comes from stimulating the processes of waste and excretion, thus getting rid of old and feeble forms. The consideration of spanhemia, or poor blood, is hardly necessary here, because it is included in the general term anæmia. Whilst it is possible to have a normal amount of blood, yet poor in some of its ele- ments, this is a rather rare condition. It will be known by the full, limp, inactive tissues, the full, blue veins, the full pulse without power in its stroke, and the ten- dency to dropsical effusions. It is really a worse con- dition than a simple anæmia, and requires more care in its treatment. As we employ means to increase the formation of blood, and add those elements necessary to its proper structure, we at the same time wish to get rid of the old stock, and the safest way to do this is by well regulated exercise and gentle stimulation of the apparatus of excretion. As remarked under the head of anæmia, special con- sideration is always given to a want of some of the cle- ments of blood, and to the means which will restore them. This is the basis of the treatment called restora tive. If the blood requires Phosphorus, it will not do to give it Iron, as when it requires Iron it will not do to give it Sulphur or a bitter. The special symptoms heretofore named, showing these defects, should be closely studied. But the blood may be bad, or changes may be going on within it which will work its destruction. You may say that "bad blood" is a popular myth, and does well enough to base a nostrum advertisement upon, but 312 STUDY OF DIAGNOSIS. it will hardly do for specific medication (?) There you are wrong, for "bad blood" is a real, tangible entity, with definite expressions, and a definite therapeutics. How will we recognize it? Assuredly in the ordinary way, by an inspection of it where it shows at the sur- face, by any material (secretion) that is drawn from it, and by wrongs in the nutritive function which is based upon it. When you think of these methods for a moment you will see that they have a physiological basis, are plain, and eminently practical. In acute disease we are more interested in those changes going on in the blood which we call septic, than in any special material contained within it, and these changes are more readily recognized by exuda- tions than other means. Attention has already been called to the secretions and deposits upon the tongue, as evidencing the condition of the blood. We find that all exudations that might be called dirty, and all changes in color toward brown and black, might be regarded as certain evidence of sepsis, and of the impairment of the blood. We put the proposition in this form-" as are the secretions of the mouth (notably the coating of the tongue) dirty or of deep color, so is the intensity of sepsis, and the death of the blood." In so far as the term typhoid is applicable to sepsis, these symptoms are among the most prominent in typhoid diseases. Any exudation will serve to show the character of the blood as well as the coating upon the tongue. The discharges from the bowels and of urine, the sputa in disease of the respiratory apparatus, the lochia in puer-- peral disease, the "washings-of-meat" discharges in dysentery, the secretions of an ulcer, the sanies of an injury or surgical operation, all tell the story explicitly. STUDY OF DIAGNOSIS. 313 It is not possible to get a good secretion or exudation from septic blood, and the character of the one will show the condition of the other In some forms of chronic disease there is effete or imperfectly elaborated albuminoid material in the blood in considerable quantity. It serves to lower the char- acter of this fluid, and to impair all vital activities, and by influencing the nutrition of structures it gives rise. to local disease. This bad blood has been a basis for the administration of the various compounds called alte- rative, so extensively employed by the profession, and also for nostrum venders, and no doubt the treatment adopted, by increasing waste and nutrition, has cured many cases. The evidence of bad blood is best found in wrongs of excretion and of nutrition. There can not be a wrong of this character without an effort upon the part of the skin, kidneys and bowels to remove the unpleasant material, and we will usually find that all three of these emunctories show a lesion caused by the effort, though one may suffer more than another. In the case of the skin it manifests itself in cutaneous disease, taking the forms of the exanthemata in the simpler cases, and the graver forms of the pustulæ, squamæ and tuberculæ, when the lesion is more persistent and severe. This fact has long been recognized, in so far as the treat- ment of skin diseases has embraced means for remov- ing effete and unpleasant materials from the blood. We frequently hear it remarked, "I know my blood is bad, because my flesh does not heal easily, and wounds and scratches inflame and suppurate." True there is something wrong here, and it may be "bad blood," according to our definition above. At least in 27 314 STUDY OF DIAGNOSIS. a large number of cases, a treatment that looks to the increase of excretion, and better digestion and blood- making, removes all the unpleasantness. In the re- maining cases some special material of the blood is wanting, frequently Lime, sometimes Soda, Potash, Phosphorus, etc. In some cases the urinary apparatus is the special seat of suffering. The entire apparatus is irritable, and the urine contains an abundance of ammoniacal com- pounds, and gives characteristic deposits. The effort at removal may be continued by these organs, until severe disease is induced, as seen in some cases of chronic in- flammation, and an occasional case of degeneration. The bowels always suffer more or less, indeed I hardly think it possible that this condition should continue long, without a loss of regularity in defecation, and a change in the character of the stools. The lesions of nutrition may take the form of de- generation, or of deposits. In the one case we have the symptoms heretofore described, of enfeebled func- tion, and a want of expression in the soft tissues. In the other comes the evidence of local disease, enlarge- ment preceding inflammatory action, which runs a very irregular course. The last is so important an evidence that it is well to read it over. Whenever swelling and change in the form and functions of a part precede inflammatory action, there is a wrong of the blood, and means must be employed to remove the unpleasant material by excretion, and to provide for better blood- making. In place of thinking of certain remedies called "alte. rative," which act in "an insensible and inexplicable manner," it is process of cure. • STUDY OF DIAGNOSIS. 315 The bad material is to be removed, and good material is to be introduced in its place. We wish to know whether it is necessary to employ means to stimulate retrograde metamorphosis, by exercise or medicines, to increase the processes of combustion, to employ remedies that modify and arrest the septic processes, or to use such as increase excretion It is possible that the habits and surroundings of the patient must be changed before a cure is effected, or that he should have better food, better digestion, or better blood- making. In thus getting a better blood, there is less tendency to depravation. THE CIRCULATION OF THE BLOOD. Among the most common lesions in disease are wrongs of the circulation of the blood. We may state it as an axiom that the condition of health requires a circulation normal in time and character, and just in proportion as we have a change from this normal standard we have severity of disease. The time of the pulse varies greatly in different individuals in a state of health, in the adult having a range of from 50 to 90 beats per minute, yet in its other characteristics it is pretty uniform, and can hardly be mistaken. The finger on the pulse is trained to determine lesions of the circulation, and should rarely make any mistake. The wrongs of the circulation may be general or local, and classified under the three heads. excess, de- fect and perversion. The first has reference to rapidity, the second to an impairment or checking of the circu- lation, and the third may embrace cases in which the circulation is not uniform, or is irregular. } 1 316 STUDY OF DIAGNOSIS. Increased frequency of pulse is one of the character- istic symptoms of fever, and is usually associated with a proportionate increase of temperature. As a rule we estimate that ten pulsations represent 1° of tempera- ture—that is for each degree of increased temperature we may expect to find an increase of ten pulsations per minute. There are many exceptions to this rule, the increased frequency of pulse being sometimes more, sometimes less, and indeed sometimes showing but little relation. As a rule, increased frequency of pulse represents gravity of disease, and we are accustomed to think of it as an unpleasant symptom. As is the frequency of the pulse, so is the arrest of secretion, the increase of heat, the impairment of digestion and blood- making, the arrest of nutrition, the development and progress of sepsis, the progress of inflammatory dis- éase, and the danger to life, local and general. Hence the importance of means which influence the circula- tion, reducing its frequency without impairing its free- dom. FREQUENCY OF PULSE may be the basis of fever or inflammation, and when the pulse is brought down to a normal standard all the other phenomena of disease may disappear. Thus we often observe under the in- fluence of the special sedatives, that as the frequency of pulse is reduced, the temperature falls, the nervous. system is relieved, the skin softens and becomes moist, the urine is increased, the bowels move of themselves," and the appetite returns. Or, in case of inflammation, the pain ceases, there is less heat, redness and swelling, and resolution rapidly progresses to complete restora- tion. These results are so common, that we are sur- prised in some seasons and in some cases to find that the sedatives do not seem to produce sedation. STUDY OF DIAGNOSIS. 317 等 ​This brings up the important point in the study of disease that there is a first and predominant wrong upon which the entire morbid process rests. In some cases, as in the instances given, this is so markedly the case that when we have removed this, the whole disease rapidly fades away. But in others this simply paves the way for the doing of something else, and this again for the restoration of other functions, and thus a suc- cession of means may be required in a single case. It will not do to say here, I have frequency of pulse, and my patient requires a sedative, taking any one of this class at random. The ten or a dozen remedies grouped under this head are not alike, and can not be used one for the other. It is true that we may so sub- stitute Veratrum and Aconite in many cases, but even these had better be given according to the special indi- cations heretofore named-Veratrum when the pulse is full, Aconite when it is small. Then we have Digitalis when the impulse is feeble, Lobelia when it is op- pressed and the artery is turgid with blood, Gelsemi- num when it is full and. vibratile, Belladonna when it is full, soft, and without strength, etc. For these indica- tions and others, the reader is referred to a former con- sideration of the pulse as an element of diagnosis. SLOWNESS OF PULSE is not a common symptom in disease, but is occasionally met with in chronic disease. It indicates a want of innervation, or excitability of parts supplied from the sympathetic. The wrong may be found in degeneration of tissue, or simply a want of waste and nutrition, the tissues becoming old and in- active. In some cases the pulse will be slow when the patient has remained quiet for some time, but is in. creased in frequency upon exertion. 1 318 STUDY OF DIAGNOSIS. These cases will be benefited by the use of small doses of Lobelia, Digitalis, or Ergot, with the use of means to stimulate increased waste and nutrition. Changes in the character of the pulse are of very fre- quent occurrence, and many of them have already been named in connection with special remedies. In most severe diseases change in the character of the pulse will be found associated with frequency, and will prob- ably point out the sedative which will be found most useful. As heretofore stated, our examination of the pulse has reference to size, the movement of the mass of the blood, the impulse of the wave, its length, gen- eral character and termination, and the inter wave- current. A reference to any sphygmographic illustra- tions will show that there is very great variation in all of these, and that they do represent definite pathologi- cal conditions. + Irregular distribution of blood is frequently met with in disease, and a popular expression in treatment is, "equalize the circulation." Some have laughed at the expression as being indefinite, unscientific, and partak- ing of the character of "old women's" medicine. But there is no plainer pathological fact than that the cir- culation of blood is unequal in many instances-here too much blood, there too little-a want of circulation to the extremities and surface, too much blood in the cavities of the body. That such inequality is the cause of disease is very easily shown by many examples Every one will recollect the cold feet and chilled sur- face that attends an ordinary bad cold, and will recall the local and general wrong that comes from a similar condition at the period of the menstrual flow, very greatly increased by the local stasis of blood in the STUDY OF DIAGNOSIS319 DIAG . uterus if the flow should be stopped. Many can recall cases of chronic disease, associated with cold feet and a tendency to chilliness of the surface from imperfect circulation, and they will recollect that such cases were very intractable. Some will recall cases of pneumonia or of typhoid fever, in which an irregularity of the cir- culation, and a tendency to accumulation of blood in the cavities, and a want of blood to extremities and surface were prominent features, and they will recall the gravity of such cases. If As the mind recalls these well-known facts, the im- portance of equalizing the circulation will be seen. If in the commencement of a cold, means are employed to give an equally vigorous circulation to surface and extremities, the mucous membranes cease to suffer in chronic disease we so improve the circulation that all parts receive an equal quantity of blood, we have ac- complished one of the essential things necessary to re- covery. If in severe local disease, or the graver acute affections called typhoid, we find an irregular distribu- tion of blood and heat, getting well will probably de- pend upon our ability to rectify this wrong. THE LOCAL LESIONS OF THE CIRCULATION that interest us most are embraced under the head of hyperæmia, or an excess of blood in a part. This has special reference to the capillary circulation, though arteries and veins. are involved to a limited extent. The condition of local hyperemia is easily understood and recognized. In health the mass of capillaries are not full, indeed it is impossible that they should be full at once. If there is an increased amount of blood in a part, with its motion unchanged, there will be increase of size-swell- 320 STUDY OF DIAGNOSIS. ing-redness, if the part is superficial, and increase of temperature and sensitiveness. Whilst it is possible to have the condition above named, it is uncommon. As a rule there is a change in the rapidity of the circulation as well. Thus we divide hyperemia into two varieties, active and passive-in the one there is excess of blood in a part with its move- .ment increased, and in the other excess of blood in a part with its movement diminished. We call the first determination of blood, and the second congestion. It will not do to mistake these pathological conditions, as the treatment of one is almost the opposite of that of the other. The cause of determination of blood is one-irrita- tion-ubi irritatio ibi fluxus; and the condition of the part is one of excitation. The symptoms are very clear-there is swelling, heat, increased sensitiveness, and redness. In minor degree the functional activity of organs and parts is increased; but when in excess, though the part is excited, the function is diminished. If now we compare with this the condition of the capillary circulation in congestion, we will see that there is much difference. In this the capillaries are filled with blood, but the movement of the blood is sluggish, or entirely arrested in some vessels. The active life of the part is impaired to the extent of the impairment in the circulation, and all the expressions show dullness and want of functional activity. Whilst there was but one cause for determination of blood, in congestion we may have three. The principal one of these is an impairment of the life of the part- the structures being enfeebled the capillaries yield to the visa tergo of the blood. In some cases an irritation STUDY OF DIAGNOSIS. 321 # of the part is a first cause, determining a greater amount of blood to it than its weakened vessels can withstand. In other cases an obstruction to the return current by way of the veins, is a principal cause. As before named, the symptoms are all of impaired function and oppression, and when we compare this with the excitation of the active state of determination of blood, the distinction will be clear. We say that the sensations are of fullness, weight, dullness, and if there is pain it will partake of these characters. The objective symptoms when near the surface are of swell- ing, and an increased redness that has not the bright- ness of the active circulation; the temperature may or may not be increased. If we take some examples of the two conditions, the subject may be clearer. In determination to the brain, there is a flushed face (bright), bright eyes, contracted pupils, increased temperature, and excitation of func- tion-the patient being excited, restless and sleepless. In congestion the face is usually flushed (dusky, pur- plish or livid), the eyes are dull, pupils dilated or im- mobile, the mind is sluggish and the patient inclined to coma. If we take the lungs, we find in determina- tion a rapid, uneasy respiration, characterized by quick movements of the walls of the chest, and the patient shows the excitation in the sharp, forcible cough, and frequent change of position to get relief. The func- tional activity of the lungs being increased, the color of the blood when it reaches the surface is brighter than usual, and the surface is therefore flushed. In conges- tion, the movement of the chest is sluggish, labored and oppressed, and the cough has a like dull and oppressed character. The function of the lungs being diminished 322 STUDY OF DIAGNOSIS. the surface is inclined to be dull, dusky, or livid. If we take a diarrhoea as an example, the symptoms are quite as clear. With determination of blood, there is marked uneasiness, and the evacuations are unpleasant or possibly painful, and attended with some tenesmus. From congestion, the bowels are tumid, have a sensa- tion of weight and fullness, and the discharges are free and without uneasiness. Whenever we find these two conditions, the symp- toms will have the same character, and will be shown by the sensations, and by the function of the part. In determination there is the feeling of increased activity, and in congestion the feeling of impaired activity; in determination there is excited function, in congestion. impairment of function. As the cause of determination is irritation of the part, any agent which will remove this irritation becomes a remedy. As the circulation in its entirety is controlled by a system of nerves, a lesion of a part may some- times be best relieved by an action upon the whole through the sympathetic. Determination of blood to any part may be relieved by the use of Veratrum, Aconite and Gelseminum. Other than these general remedies, we select those that influence the special part affected, and that remove irritation. In determination to the brain we use Gelseminum; to the lungs Vera- trum or Ipecac; to the kidneys Gelseminum; to the bladder Eryngium; to the bowels Aconite and Ipecac; to the uterus Aconite and Macrotys. In so far as we use local applications they are selected in the same way wet packs, poultices, fomentations, enemata, in- halations, etc., are selected with reference to their seda- tive character. STUDY OF DIAGNOSIS 323 t In congestion the part requires stimulation, especially stimulation through the sympathetic. It may also be influenced to a greater or less extent by remedies stimulating the circulation at large. Thus Belladonna, Lobelia, and to some extent Aconite, are of value in all cases of congestion. Other remedies are selected with reference to their action upon the part, as stimulants or excitants. In congestion of the brain we use Bella- donna; in congestion of the lungs or of the heart, Lobelia; in congestion of the abdominal viscera, Nux Vomica; in congestion of the kidneys, Belladonna, etc. In selecting local applications we observe the same. rule; whatever their form, they should be excitant to the part. In studying the action of remedies, we first wish to know where they act, and second the kind of action. If a part is diseased, we wish a remedy that acts upon that part particularly, and which does that which is necessary to restore it to health. In the case of determination of blood-the active circulation-we want a remedy that will remove irritation, and the un- due excitation of its circulation; in congestion we want a remedy that will increase the life of a part, or that will give the necessary stimulus to the capillary vessels. According to Dr. Williams, inflammation is a local hyperemia, with the movement of the blood partly in- creased and partly diminished. We study this process of disease, with reference to its cause, the lesion of the circulation, the exudation, and the result or termina- tion. The cause is one, irritation with such impairment of vegetative life. From the irritation comes an in- creased circulation to the part, the capillaries are filled with blood, which in some moves slower and slower, until the circulation through them is arrested; and yet 324 STUDY OF DIAGNOSIS. But in others the movement of the blood still continues rapid. As the capillaries lose their strength and be come thus filled, the fluid portion of the blood is exuded into the intercapillary spaces, or upon free surfaces. This completes the pathological process, and we next study its result upon the life of the part. If the origi- nal lesion has not impaired the vegetative life too much, or the lesion of the circulation has not been too great, we find that after a time these minute vessels regain their tone, and the circulation is re-established in them. As the current of blood commences to flow through them, the material exuded is drawn into the current and carried away, thus leaving the part in its original condition. This termination is called "resolution," and is the result most to be desired in all cases. if the life of the part be so impaired by the cause, that it can not renew itself; or if the impairment of the cir- culation be so great as prevent its receiving the necessary amount of oxygen, and the removal of car- bonic acid gas, then it must die and be removed. This death and removal takes place in two ways-by sup- puration, and by gangrene or mortification. In sup: puration the process of death is modified by a lower form of life-the production of pus-cells, from the formative cells of the part, and thus the remainder of the body is protected in part, and repair facilitated. But if the impairment of life is greater than this, the part dies, and is removed en masse, by the suppurative process when the tissues still retain sufficient life. The symptoms of inflammation, according to the old authorities, are pain, heat, swelling and redness, and for superficial parts these are characteristic and definite, but for internal and concealed parts we are obliged to STUDY OF DIAGNOSIS. 325 rely upon the first, and the evidences of impaired func- tion, and the influence upon the general health. Pain is a very constant expression of inflammation, though it is very common from other causes. It varies from simple uneasiness from over-excitation, to the sharpest and most severe suffering, and its intensity is not to be taken as the measure of inflammatory action in any case. It becomes symptomatic of inflammation only when there is evidence of a wrong circulation, and increase of temperature, general or local. Heat is a constant symptom, and much more reliable than pain. It may be but local in superficial inflam- mation, or when but a small and unimportant part is affected, but is general when an important part or much tissue is involved. In some cases the patient's sense of heat may be taken as evidence, though this is very liable to error. As a rule the temperature of an in- flamed part will not rise higher than 102°, unless there is a corresponding elevation in the temperature of the body, and there is rarely more than one or two degrees difference between the general and local temperature. The sense of heat, when the hand is placed upon a superficial inflammation, is due in part to arrest of secretion from the skin, which is also the cause of any difference there may be in temperatuře. Swelling is also a constant symptom, thougn not so marked when free surfaces are involved, or very dense tissues. It is not a reliable symptom, however, for it may be due to changes in the nutrition of a part, to growths, deposits and exudations. To be of any im- portance in diagnosis it must be associated with evi- dences of derangement of the circulation, and with in- creased heat. 326 STUDY OF DIAGNOSIS. Redness is only an evidence in superficial inflamma tion, and is due to the presence of a large number of red globules. It is deeper than in determination of blood, though it may be simulated by some rarer con- ditions of the skin. Among the prominent and most valuable symptoms of inflammation are wrongs of function; these are con- stant and characteristic. In the early stage of excite- ment the functional activity of some parts will be in- creased; but in a majority it simply shows excitement and is really impaired. As the capillary stasis in- creases, and exudation occurs, the function becomes more and more impaired, until in some cases it is com- pletely arrested. Thus in inflammation of the brain, we have at first great mental excitement, then delirium, then probably incoherent (muttering) delirium, and finally from exudation-coma. In this case the symp- toms of the first and second stages are almost opposite- active delirium and coma. In inflammation of the lungs we find at first increased activity and a rapid oxi- dation of the blood; but in the second stage there is oppression, and an imperfect aeration of the blood. In inflammation of the liver, there may be at first stage an increase of biliary secretion, whilst in the second there is complete arrest: So in inflammation of the kidneys, the first excitement produces increased secretion of urine, whilst the second may arrest it entirely. The different phases of the inflammatory process and its results, require care in diagnosis. Recognizing the presence of an inflammation, we want to know the danger to the life of the part, and to the life as a whole. In this respect it may be said, that those cases of but moderate excitement are most favorable. When the STUDY OF DIAGNOSIS. 327 vascular and nervous excitement are extreme we may anticipate an unfavorable result, as well as when we have marked swelling and redness, with impaired sen- sibility and arrest of function. The sensation given to the touch will be most reliable in external inflamma tions; the greater the departure from the normal stand ard, the greater the danger to the tissues. Suppuration is announced by an increased fullness of the tissues, a sense of increased tension, and a change in the character of the pain, which becomes throbbing. If but a moderate amount of tissue is involved in an unimportant part, suppuration is followed by relief of the general symptoms, but when considerable tissue is broken down, or important organs are involved, it is frequently ushered in with a chill, and attended by a fever having somewhat the character of hectic. Gangrene of external parts is announced by the change in color-purplish or black-by coldness, and a want of sensibility. Internally it is announced by great prostration, the subsidence of pain, loss of sensi- bility, and a soft, feeble pulse. The general symptoms are those of fever. The cause of inflammation is depressing to the life of the indi- vidual as well as to the life of the part, and when con- siderable`structures are involved the expressions are very distinct. The first influence gives the listlessness, languor and loss of function; this culminates in a chill or rigcr; and this is followed by the symptoms of febrile reaction-frequent pulse, increased temperature, arrest of secretion, and derangement of the nervous system. In the severer cases of inflammation these general symptoms are as pronounced as in fever, and it is some- 328 STUDY OF DIAGNOSIS. times difficult to determine a local lesion, except by close examination and attention to special symptoms. If care is used, however, a special wrong of function will attract attention to a part or organ, and symptoms of inflammation will be detected. The close relationship between fever and inflamma- tion should not be forgotten, and indeed it is well in practice to recognize them as requiring the same treat- ment; an inflammation is fever of a part. The reme- dies for fever are remedies for inflammation, and in many cases they are the best and most direct we have, If, in the majority of cases, the pulse is brought down to a normal standard, the temperature reduced, inner- vation normal, and the secretions restored, the inflam- matory process will cease, and if the life of the part has not been too much impaired, resolution will be rapidly effected. In studying the treatment of inflammation it is well to bear in mind the different phases of the morbid pro- cess. First, irritation and determination of blood; second, impairment of capillary circulation until its final arrest, and lastly, the impairment of the life of the tissues from this and the exudation. The irritation may continue through the entire progress of the in- flammation, and thus will continuously attract the blood to the part, whilst from the commencement there are marked evidences of impairment of tissue life. Anything that will lessen or remove irritation will prove a remedy in inflammation. Take away the irri- ation, and you take away the cause of an excited cir- culation of blood to and in a part. The general means have been already referred to, but some of them are local as well. The sedatives, Veratrum and Aconite, 1 STUDY OF DIAGNOSIS. 329 1 influence the inflammatory process directly, wherever it may be located. So do the indirect sedatives of the olden time—the nauseant emetics, and the more power- ful diaphoretics. In the selection of local means, we must closely value the inflammatory process, and determine the kind of influence most desirable. It may be directly sedative, removing irritation, and in some instances may be depressant. In others, whilst an object is to remove irritation, we also keep in view the greater ne- cessity of stimulation to the capillary circulation. And in many we keep in view, as a principal object, such treatment as will increase the life of the tissues. When we have determined by an examination that the inflammation must terminate in suppuration, we should not forget that resolution goes on at the same time, and that it is our business to confine the suppu- rative process to as small a proportion as possible, and to obtain resolution as far as is practicable. The treat- ment is just the same as in mortification; we wish to restrict the death to as small a portion as possible, and we do it by strengthening the life of the tissues. The means named are those which might be em- braced under the head of physiological medicine, and give us an excellent basis of treatment in many cases. In some we have special means, the action of which can not be explained in this way. These remedies are indicated by some special expression of disease, and as we have already seen, they prove curative in very diverse (seemingly) conditions of disease. I need but instance the action of Tincture of Muriate of Iron in erysipelas; the action of Rhus, Bryonia and Macrotys and some other agents in the arrest of special inflam- 330 STUDY OF DIAGNOSIS. mations, or the special action on individual parts or associate functions, as Phytolacca in mammary inflam- mation, or in disease arising from nursing. INNERVATION, We divide the nervous system into three parts, for study-the brain, the spinal cord, and sympathetic. The first is the organ of conscious life, the second of automatic movement, and the third governs and asso- ciates the functions of vegetative life. The functions of the brain are reason, emotion, volition and sensation ; of the spinal cord, the co-ordination of muscular action, and the functions of respiration, defecation and urina- tion, and expulsion of the uterine contents; and of the sympathetic, digestion, circulation, nutrition, and secre- tion and excretion. Lesions of innervation may be due to a change in the condition or structure of the nerve centres, or to some lesion external to these. The more common lesions are of the circulation, and we have them from the two opposite conditions of an excited circulation—too much blood in a part, or an enfeebled circulation—too little blood in a part. Whenever we find these lesions, this. is the first question we ask, and usually the symptoms of hyperæmia or anæmia will be distinctly marked. A physiological treatment will be based upon this, to a considerable extent. If we have hyperemia we use remedies which lessen excitation, if it is anæmia we employ such agents as stimulate and give a more vig- orous circulation. In the first cases the treatment may be temporarily depressant, in the second it is always restorative and tonic. STUDY OF DIAGNOSIS. 331 We DELIRIUM in acute disease is readily recognized. The inability to reason rightly, and the illogical and unreasonable expressions tell the story clearly. say delirium is active, it is passive, it is coherent, it s in- coherent-taking the entire range of that active con- tinued expression, in which it is almost impossible to control the patient, to the dreamy delirium of typhoid fever, in which the patient is calm and still, or the mut tering delirium that soon passes into coma. But we are not so much interested in the expression of delirium as we are in the symptoms indicating the physical condition of the brain. We want to know whether there is an active circulation, or an enfeebled one; whether the patient can bear temporary depres- sants, or requires stimulants and restoratives. The practitioner will recognize the pertinence of this in- 'quiry, as it points the way to the selection of direct remedies. In the first case we use the sedatives and associate means that relieve excitement, and the special remedy, Gelseminum. In the second we use Quinine, stimulants, restoratives, tonics and food. It may be remarked here, that in addition to the means selected in this way, any remedy which may be indicated by special symptoms, is a remedy for delirium. Thus we see a delirium rapidly disappear under the use of an acid, an alkali, one of the antiseptics, Rhus, and other agents heretofore spoken of. The two methods. may be sometimes combined; though, if the symptoms indicating a single remedy are pronounced it should be first given. In delirium tremens, we also find two conditions of the brain as a basis for the wrong reason. A want of re- cognition of this fact has given us some queer medical 332 STUDY OF DIAGNOSIS. literature. For a time we will find our medical peri- odicals teeming with recommendations of stimulants, tonics and food as the means of cure; then for a time they will recommend a sedative and depressant treat- ment. It never seems to have impressed the profession that delirium tremens might arise from two opposite conditions of the brain-one in which the circulation of the organ is depressed, and the other in which it is too active-and yet this is very certainly the case. If we find our patient with sunken eyes, blanched or livid lips, cold extremities, and a small and feeble pulse, we know that he requires stimulants, and especially food. In the early stage of such a case we would ex- pect to arrest its progress by the stimulant action of Nux, Iodine and Hydrastis, and the use of beef-tea. We can see how it is that Capsicum in large doses should prove curative, and how small doses of Quinine, Opium and Camphor exert a beneficial influence. But if we find him with a florid face, full, bright eyes, increased temperature, and a full, hard pulse, we recog- nize a condition of undue excitement, and would hardly use the treatment just named, though it has proven successful in cases of delirium tremens. On the con- trary, we propose to select remedies which will remove the undue excitement of the circulation, and give rest to the brain. Thus we give full doses of Veratrum and Gelseminum, saline cathartics and diaphoretics, and possibly follow with Bromide of Potash and Chloral. If we study puerperal mania, or acute insanity, we find two classes of cases, as in delirium tremens. In one from exhaustive discharges, lactation, and starva- tion (the regulation toast and tea), we have a condition of anæmia. We find the face pallid, the eyes dull, the STUDY OF DIAGNOSIS. 333 tongue broad and pallid, the pulse small and feeble, and the extremities cool. We at once recognize that this patient wants proper stimulants, tonics, restoratives, and food, and as we give them we find that there is a steady improvement. If we had employed the olden. stereotyped treatment of purgatives and depletives, we would have had a funeral, or a case for the lunatic asylum. But in other cases we do find a flushed face, full, bright eyes, contracted tongue, increased temperature, a full, hard pulse, and partial arrest of secretion. The case is just as clear as the first one, and we cure it by the use of the proper sedative, Gelseminum, and means which will restore secretion and excretion. In this case temporary depressants may sometimes be employed with good results. In chronic mania, the diagnosis of the physical condi- tions of brain and body will be made in the usual way. All wrongs of function and structure are to be removed as far as possible, and the patient placed in the best possible health. Thus if there are special indications for any single remedy, this should be given. In some cases the action of such agents is very speedy and per- manent. With regard to the psychological treatment, but little need be said. It must be based upon this law of nature" that in proportion as an organ or function is used it gains strength; and as it is disused it loses strength." In so far as the morbid mind has material to feed upon, and has exercise, the insanity will be in creased; and in so far as the normal functions of the mind are disused, they become enfeebled. The object, therefore, is, to call out the mind in orderly channels as 334 STUDY OF DIAGNOS18. ? much as possible, and to give as little cause for the i sane manifestations as possible, that the one may gain strength and the other lose it. What has been said with reference to reason is appli- cable to the emotions, in so far as the necessity of re- cognizing the physical lesions are concerned. Emo- tional wrongs have a physical basis, and if perfect health can be restored, they will pass away. Indeed, permanent cures can only be effected in this way. The wrongs of the emotions may be in either of the three ways—excess, defect and perversion—but the first and last associated, are usually met with. The expres- sion is so distinct that it can hardly be mistaken; too great a manifestation and rapid alternation of grief, joy, hope, fear, exaltation, depression, etc., without sufficient or corresponding cause, tells the story. Hys- teria is the type of this class of diseases, though it in- volves other than the emotions. A defect in volition is often noticed as an element of mental disease, and as an attendant upon some other diseases. It is often remarked that the strong will is an important means of recovery-" that when one wills to get well, he will get well "-and every practitioner will have noticed the difficulty of managing those cases in which there was an indifference, or want of volition. The expression of the face will frequently give this in- formation before a word is spoken. The firm expres- sion of the muscles of the mouth and closure of the jaws is characteristic of strong will; whilst the relaxed muscles of the mouth, and the general want of expres sion, tells of enfeebled will. Recovery will frequently depend as much, or more, upon strengthening the will, as upon the use of reme- 1 STUDY OF DIAGNOSIS. 335 } dies. If we can call it into action, by presenting addi- tional motives for its exercise, or by a judicious stimu- lation from attendants and friends, we find that it will grow by exercise, and that which was difficult to the patient at first soon becomes easy and natural. The brain receives impressions from the world with- out, and from the various parts of the body, through the apparatus and nerves of special and general sense— and this we call sensation. In the healthy body all sensations from it are pleasurable, and the use of the special senses is a source of pleasure. But in disease sensation is unpleasant, and a source of discomfort, and we designate it as pain. It is well to become thor- oughly conscious of this, by passing the various sensa- tions in review. To the sound eye, use is a pleasure, and we only know the organ through the pleasurable sense of vision; the impulse of sound waves upon the ear is pleasurable; so is the use of the sense of taste, and of smell. When we direct the mind to the appa- ratus of digestion, we find that it gives pleasurable sen- sations, in so far as it gives sensation at all; the func- tion of respiration is pleasurable, and so is defecation. and urination. If When this sense of pleasure is lost, we may know that an organ or part is diseased, though the discomfort. may not tell us the quality or amount of disease. the use of the eye becomes a source of discomfort, our attention is called to that organ as the seat of disease, · and we at once make a proper examination to deter- mine its character. If the use of the ear is a source of discomfort, we at once conclude that it is the seat of disease, and we make the necessary examinations to determine its exact character. If there be discomfort } 336 STUDY OF DIAGNOSIS. in the sense of taste, we know there is a wrong in the mouth where these nerves are distributed, or of the digestive apparatus to which these nerves stand sen- tinel. If there be discomfort in the sense of smell, we at once conclude there is disease of the nasal cavities. So when there is discomfort from any apparatus or function-the throat, larynx, lungs, stomach, bowels, defæcation, urination, etc., we know there is disease, and having our attention directed to its seat, we pro- ceed with the proper examinations to determine its character. Persons will sometimes have their first knowledge of organs or functions through discomfort and pain. The dyspeptic realizes that he has a stomach through pain; the minister realizes that he has a larynx, when it has become irritable and painful by abuse; the location of lungs, liver, spleen, bowels, kidneys, bladder, uterus, etc., is first realized by many through the suffering of disease. It is well to bear in mind that pain may have two causes-it may be due in principal part or in whole from disease of the part that suffers, or of the brain that re- ceives the impression. To determine this is an impor- tant part of the diagnosis of pain. A little care in noting the expression of the face, the eyes, and the other functions of the brain will determine this in most cases, and this may be supplemented by a careful ex- amination of the part. The diagnosis between the pain of structural disease and neuralgia is usually made with ease. The absence of heat, redness and swelling, in any considerable de- gree, is usually sufficient, but in obscure cases it is well to carry the examination further to determine lesions of the blood, of nutrition, waste and excretion. STUDY OF DIAGNOSIS. 337 : General disease will give rise to the conditions of pain, and to a considerable extent may be considered its cause. Thus, the vascular excitement and increased temperature of fever render the brain more sensitive to impressions, and the nerves more active purveyors. The symptomatic fever that attends inflammation has the same influence in increasing pain. Thus, in those cases where pain is very severe, the means that lessen the frequency of the pulse, diminish the temperature, and establish secretion, are the most effective to cure pain. When we study the condition of the brain as a cause of pain, we find that it is not one, as generally sup- posed, but two, possibly three. In one case we have evidence of vascular excitement in the flushed face, bright eyes, contracted pupils, and increased tempera- ture. And we meet this condition with Gelseminum, the sedatives, and possibly the saline diuretics and cathartics. In the second case we find the evidence of an enfeebled circulation in the pallid, expressionless lips, the dull eyes, dilated or immobile pupils, and pos- sibly the coolness of nose, ears and forehead-the gen- eral expression is of want of stimulus. In these cases we think of nerve stimulants, of Belladonna, Quinine, Nux, Ammonia, etc. The feeling of dullness and in- clination to sleep attending some forms of pain is met especially by Belladonna and Ergot. The wrongs of perversion are not so easily determined, but with care we may find the indications for special remedies, some- times in the expression of the face, sometimes in the appearance of the tongue, and sometimes in the changes of the pulse. There is no doubt that many times the character of も ​29 338 STUDY OF DIAGNOSIS. 1 the pain may point out the special remedy for the cure of the disease, though it is not as certain as other means of diagnosis. If we could feel the pain, as we feel the pulse, it would be different, but trusting to the patient's uneducated senses, and his imperfect power of analysis and expression, we find it uncertain. If per sons are trained to close observation, analysis and ex- pression in this regard, as in some Homœopathic fami- lies, it may become very reliable. Lesions of spinal innervation are diagnosed from wrongs of function controlled by this nerve-center. Thus impairment of muscular motion may be referred to an enfeebled spinal cord, an exalted sensibility of muscles, to increased spinal innervation, whilst all forms of convulsion may be attributed to perverted spinal innervation. Among the important functions controlled from the spinal cord is that of respiration. We will sometimes find deficient respiration, that phy- sical examination will determine is not from structural disease, and we reach the conclusion that it is want of innervation. In acute disease we sometimes find this so marked, that respiration can not be carried on except through the influence of the will and the external re- spiratory muscles. We notice that so soon as the patient sleeps, respiration becomes more and more dif- ficult, until at last he is suddenly aroused by a feeling of asphyxia; thus rest is prevented, and death may re- sult. In all these cases we think of spinal stimulants as remedies, Nux Vomica and Strychnine being the type-and increasing spinal innervation, we find our patient breathes better, and gets necessary rest. The lesions of excess are rather rare, but still they deserve close study. We will find it marked in some STUDY OF DIAGNOSIS. 339 cases by excessive muscular irritability, so that the patient exhausts himself by over-exertion, or more fre- quently by that uneasiness which might be called mus- cular fret. In others the lesion is principally manifested in the respiratory muscular apparatus, giving frequent or irregular respiratory movements-respiratory fret- or sometimes severe and intractable cough from very slight internal irritation. In other cases we find the evidence in defecation and urination, giving frequency and some tenesmus, without corresponding internal disease. In these cases there is usually hyperemia of the cord, marked by a full, hard pulse, tense skin and muscular structures, and rigidity or contraction in all the expres sions of the body. The remedies will be Veratrum, Gelseminum, Sulphur in free doses, the saline cathartics and diuretics, the cold wet-sheet pack, alkaline bath, étc. In some rare cases, there is a condition of anæmia, and the patient requires Nux, Strychnine, Quinine, Iron, Arsenic, stimulant baths, with restoratives and animal foods. The lesion of perversion gives us the entire series of convulsive affections, so frequently met with in the practice of medicine. In this case the spinal cord takes complete control of the body, and sets it into disorderly movement. How the wrong is produced, or what is its exact character, is not known, but when once it has obtained, the tendency is to its repetition. There is no difficulty in its recognition; the complete arrest of the function of the brain, and the disorderly activity of the muscles is so marked that it can not be mistaken. Two causes of convulsions are recognized: the one 340 STUDY OF DIAGNOSIS. disease of the spinal cord itself-intrinsic, the other a lesion of some other part-extrinsic. The exact condi- tions of the spinal cord are not well known, but we may recognize one of vascular excitement, and one of atony and impaired circulation. In the first the surface and face is flushed, the eyes bright and pupils con- tracted, the pulse somewhat full and hard, and the tem- perature usually increased. In the other the face is pallid or livid, the eyes dull, the pupils dilated in the intervals of spasm, the extremities cold, and the pulse small and frequent. There is a third case in which there is very evident congestion of the cord, and the face will be full and dusky, the eyes protruding, and the pulse full and oppressed. These cases are usually so well marked that the diag- nosis is not difficult, and a correct treatment is at once suggested. In the first case we use Gelseminum or Veratrum, or both. In the second case we use Lobelia, Chloroform, Bromide of Ammonium, or the fœtid gum resins. In the third case, Belladonna, Ergot, and pos- sibly Aconite; Bromide of Ammonium is sometimes an excellent remedy here.. It is most absurd to think of treating all cases of convulsions with one prescription. Specific Medication never goes that far, it treats conditions of disease, and not names. The instance of convulsions furnishes a very good example of the necessity of accurate diag- nosis. It is well to note here that the spinal cord having formed a habit of convulsive action, has a tendency to repeat this at varying intervals, even though no change of structure, or disease of other parts can be found to account for it. In addition to the treatment for the STUDY OF DIAGNOSIS. 341 convulsions, this habit, or tendency to recurrence is to be broken up, and we find in many cases that the longer the convulsive action can be postponed, the less disposition there is to its recurrence. In the treatment of some cases of epilepsy, this is a principal object, and any means which will even temporarily ward off an attack, becomes a part of the cure. The extrinsic causes deserve consideration, though many times they have ceased before we are called to treat the cases. If in infancy we find the gums swollen and purplish, a free incision over the coming tooth may relieve the convulsion at once. If green fruit or other irritant ingesta has proven a cause of convulsions through irritation of the stomach, an emetic will give the speediest relief. If it has come from irritation of the solar plexus, attended by pain-colic-Nux Vomica will give relief. If from irritating materials in the intestine, cathartic enemata may be of great service. If from partial suppression of urine, the hot packs over the loins, with Gelseminum, will be the treatment. Worms may be a cause of convulsions, and yet I do not think it advisable to give worm medicines, until all symptoms of nervous irritation and convulsions have been removed. Otherwise the additional irritation from the worm medicine may prove fatal. In epilepsy the original cause may pass away in a few hours, or it may persist for years. Thus in some cases an epilepsy will arise from a temporary irritation of the stomach, the intestinal canal, or the reproductive apparatus, and no traces of the lesion will be found when we are called to treat the patient. But in other cases the lesions will persist, and their occasional or periodical increase will determine the convulsion. Thus, 342 STUDY OF DIAGNOSIS. menstrual derangement may prove a continuous cause, as will disease of kidneys, stomach, bowels, and some other parts. In all cases the examination is carefully made to detect local lesions, and when found, means are employed to remove them as part of the cure. The study of paralysis might follow the consideration of the lesions of the brain and spinal cord, as it may embrace either or both.. When the lesion is of one of the hemispheres of the brain, the paralysis is of one- half of the body, divided vertically, and is called hemi- plegia. When it is of the spinal cord, it is of the lower portion of the body, the division being horizontal, and involves all parts below the seat of disease; this is called paraplegia. When of but limited extent, we call it local paralysis, and we trace it, to a lesion in the course of the nerves, or to a limited disease of the cen tre from which the nerve has its origin. Ha 1. : We must not suppose that when we have diagnosed a paralysis by the impairment or total loss of motion or sensation, or both, that we are ready to make a pre: scription, and that all that is necessary to be done is to stimulate the nerve centres or the affected parts, by Strychnia, or electricity. We want to know the char- acter of the wrong, both of the nerve centres and of the general health, and when we have determined this we can prescribe intelligently... ..! In hemiplegia we will find two conditions of the brain. In one case we will have a flushed face, bright eyes, contracted pupils, increased temperature, im- paired excretion, and a pulse characterized by fullness and hardness. Surely no sane person would treat this case with Nux or Strychnine? On the contrary, we use the proper sedative, Gelseminum, means to establish STUDY OF DIAGNOSIS. 343 1 secretion, and possibly suppurative counter-irritation. In a second case the face is swollen and dusky, the lips livid or purple, the eye dull, pupils dilated or immobile, and the pulse full and oppressed. This patient wants Belladonna, Ergot, Bromide of Ammonium, and wet- cups to the spine, with, possibly, stimulating cathartics. In a third case the head is cool, the face lacks expres- sion, and the pulse is nearly normal, but wants force. Every symptom points to anæmia of the brain, and to the want of restoratives. Here we give Nux or Strych- nine as nerve stimulants, the bitter tonics, good food, and use electricity for its stimulant influence. The diagnosis will take the same course in acute paraplegia, and the same means will be used in its treat- ment When it has been preceded by an injury, or by inflammation, we wish to determine as nearly as pos- sible the condition of the part, and whether or not the lesion has destroyed the nerve structures. Even here the treatment may be rational. needs doing, whether it be to promote the removal of effusion of organized lymph, or of water, or by an in- crease of waste and nutrition gradually renew the dis- eased structures until they are capable of doing their work. We do that which Wrongs of the sympathetic nervous system are so in- timately associated with lesion of the vegetative fanc- tions that we find difficulty in separating them. Pos- sibly it is only where an important part or the whole of this system is involved, that it requires special study. We e may classify these lesions as an excess, defect, or perversion, though the excess is more an undue excita- tion than an increase of power. We will find this excess marked in an unnatural and 344 STUDY OF DIAGNOSIS. } • unaccountable frequency or hardness of pulse, and an unpleasant irritability of the organs of digestion and secretion. There can be no improvement until we can have better innervation. In such cases Veratrum has a most excellent action, and followed by Arsenic, will frequently effect cures in very stubborn cases. Defect is marked by a feeble circulation, the artery giving the sensation of a want of tone or elasticity, and all the vegetative functions are feebly and imper- fectly performed. That it is not due to a wrong of the organs themselves is readily determined by other symp- toms. In these cases, Phosphorus, Sulphur, Iron, Cod Liver Oil, Pulsatilla, Digitalis, Aconite, are especially indicated, the particular remedy being selected by spe- cial symptoms. Perversion of sympathetic innervation is shown by irregularity in the performance of the vegetative func- tions, and by changes in the character of the pulse, other than frequency, strength, or feebleness, The remedies will be selected, as named in the first part of the work. The association of the sympathetic with the spinal nervous system gives us that condition of disease known as spinal irritation. It is of frequent occurrence in chronic disease, and when marked is sufficient to pre- vent a cure by the ordinary means, being a continued source of wrong innervation. It is a little singular that the source of this lesion of the spinal cord should always be an organ supplied from the sympathetic, and that irritation should be so readily propagated back- ward along these nerves. Yet it is a fact that a dis- ease of irritation can not exist long in an organ with- out some disturbance of the great sympathetic, and the 1 STUDY OF DIAGNOSIS. 345 " spinal cord immediately behind the ganglion, that fur- nish the nervous supply. Spinal irritation is usually marked by tenderness on pressure over the bodies of the vertebræ, and when such tenderness is found, it is taken as evidence of this lesion. But once in a while we will find the evidence at some distance from the spine, but always in the course or termination of the posterior spinal nerves. It has been proposed by Prof. John King, to deter- mine the locality of chronic visceral disease, by an ex- amination of the spine, and this can be done where there is spinal irritation. If the reader will refer to a text-book on anatomy, he will see that the distribution of sympathetic nerves, and connection with the spinal cord is very simple. The sympathetic ganglia send off large nerves, which before their distribution form a net- work, called a plexus, and from this the nerves are dis- tributed upon the nearest arteries. Thus if we know the source of nerve supply to a plexus, and the distri- bution of the arteries nearest to this, we will readily make the association between a particular part of the spinal-cord, and a special organ or organs. It might be remarked that the connection between the cord and the ganglia which lie upon the bodies of the vertebræ in front, is immediately backward and forward by fila- ments of communication, and that a limited portion of the gray substance of the cord is thus associated in action with a ganglion. The first cervical ganglion sends its branches upwards. on the carotids, to supply the brain and the organs of special sense; and a nerve downward, which through the cardiac plexus is distributed to the heart; thus to a certain extent associating the brain and heart in action. f $ 1 346 STUDY OF DIAGNOSIS. The other cervical ganglia send nerves downward to the cardiac plexus, which supplies the heart, and to some extent the lungs. The upper dorsal ganglia send off the great splanchnic, which passing through the diaphragm form the solar plexus, and from this the nerves are distributed upon the cœliac axis to the stomach, liver and spleen, and upon the superior me- senteric to the small intestine and pancreas. Branches from this pass downwards upon the spermatic artery to the testes in the male and the ovaries and uterus in the female. The lower dorsal ganglia furnish the lesser splanchnic nerves, which form above the renal arteries the renal plexus, and furnish nervous supply to the kidneys, ureters and bladder. The dorsal ganglia fur- nish nerves for the formation of the hypogastric plexus, which gives nervous supply to the pelvic viscera. The sacral ganglia furnish nerves for the sacral plexus, which supplies some parts at the outlets of the pelvis, and the lower extremities. The above is but a brief synopsis of this subject, and the reader will do well to give it a thorough study, and trace out the distribution of these nerves on an anatom- 'cal plate. It will be found that there is a free inter- communication between different parts, some more especially than others, and thus many sympathies ob- served in health and disease can be accounted for. • In the olden time we were in the habit of recom- mending the irritating plaster for all these cases, and though unpleasant, it may be employed with advantage in a great many. It is better, however, to determine more exactly the condition of the cord, as quite surely it is not always the same. Possibly our old division will serve our purpose here, classifying them with refer- STUDY OF DIAGNOSIS. 347 nce to the circulation-a, with vascular excitement; b, with enfeebled circulation, or spinal anemia. The case of vascular excitement will be shown in the bright eyes and contracted pupils, slight increase of temperature, and a pulse that has hardness and undue vibration as an element. It is especially the case for suppurative counter-irritation over the site of tender- ness, though I prefer, as being much pleasanter, the use of the wet-pack, of water, vinegar, or water acidulated with Sulphurous Acid. The internal remedies will em- brace Veratrum, Gelseminum, Bromide of Potash, and these may be aided by means to establish secretion. The case of anæmia of the cord will be recognized. by the dull, sunken eye, feeble circulation to the sur- face and extremities, and a pulse that wants strength. In many of these cases the skin is relaxed, and there is undue exudation. These cases may have the irritating plaster used to rubefaction, stimulant frictions, rubbing of the spine with salt water, the use of electricity (Faradization) and means of a similar character. In- ternally the remedies will embrace Nux, Ergot, stimu- lant doses of Iodine, Pulsatilla, Bromide of Ammonium, and if the pulse is small and vibratile, Rhus. There are a few cases, marked by a full, sluggish, and oppressed pulse, dull eye and dilated pupil, in which Belladonna and Ergot will prove very efficient. internal remedies, and in which a Belladonna plaster is the best local application. 348 STUDY OF DIAGNOSIS. NOSOLOGICAL CLASSIFICATION. The study of this is beyond the scope of this little volume, and the reader is referred to works on the "Practice of Medicine," or special treatises on diag nosis, in which this classification is the basis. Our study has been wholly with reference to the selection of remedies, and the ordinary nomenclature interests us only as it points us to groups of remedies. The study of nosology is of some importance in "enabling one to give appropriate names, in writing or conversing of disease, and especially as satisfying the friends of a patient, who are always desirous of having a disease named. If the reader will take the classifica- tion given, and apply the methods of examination named through this work, he will find but little diffi- culty. We will pass it in brief review, pointing out the method of study, and giving the most pronounced symptoms. CHLOROSIS.-In the early menstrual period, usually before the age of twenty; is characterized by want of blood, impaired nutrition, loss of flesh and strength, and differs from anæmia only in a greenish coloration of the otherwise blanched and bloodless skin. The name has no meaning in selecting remedies, unless in some cases, the peculiar shade of green would indicate Cop- per, and in others Sulphate of Alumina and Iron. SCORBUTIS-IS caused by a want of vegetable food, and is especially marked by softened and spongy gums, usually of a deeper color than natural; and, finally, by a tendency to deliquescence in all tissues of low organi. 1 STUDY OF DIAGNOSIS. 349 + zation, especially cicatrical tissue. The name indicates a special pathological condition, and calls for vegetable acids (Citric Acid or lemon juice), and for vegetables, especially those containing a considerable amount of Potash. DROPSY-Has different causes, which require special study. It is characterized by exudations of water into the cellular tissues—œdema, anasarca; or into the serous cavities ascites, hydrothorax, hydropericardium, hydrocephalus, hydrocele, and hydrops articuli. The diagnosis is made by the touch, which gives a different sensation from growths, deposits, or accumulations of pus, blood, or gases. It refers us to special remedies, Apocynum, Aralia, and the hydragogue cathartics and diuretics for the removal of the accumulated fluid. DIABETES MELLITUS.-Increased flow of urine, with loss of flesh and strength, and impairment of every function. Examination of the urine, as named under that head, determines the presence of sugar. The name does not point to remedies, which must be selected with reference to the symptoms in each individual case. PYÆMIA-A condition of blood simulating suppura- tion in solids, usually having its origin in injuries or wounds of loose, non-vital tissues, though it may arise. from wounds of any part in which putrescency develops. The condition may be known by the extreme restless- ness, and fear of a fatal result, a small, tremulous pulse, (sometimes the pulse has its usual inflammatory condi- tion until a short time before death), a peculiar con- striction of tissue about the base of the brain, pinched nose, and a general expression of irritability. It points 35C STUDY OF DIAGNOSIS. us to antiseptics and good food, as the means of cure. Opiates should not be used to relieve pain, if it is pos- sible to get along without them. TUBERCULOSIS.-The impairment of the blood that gives rise to aplastic and cacoplastic deposits, has already been described. There is impairment of diges- tion, blood-making and nutrition, with loss of flesh and strength, local symptoms indicating the situation of the deposit. The treatment is suggested by the above description-increase retrograde metamorpho- sis and excretion, and remove the low albuminoid mate- rials, and improve nutrition. FEVER.-The different forms of fever have been de- scribed in a preceding classification, and it is only necessary here to call attention to the principal phe- nomena, and the treatment. A fever is a disease of four stages forming, cold, hot and sweating. The symptoms of the first are of prostration-there is an impairment of life. In the second this impairment is still greater, especially of innervation and circulation, and the patient feels cold. In the third vascular and nervous excitement are marked, the pulse is frequent, the temperature increased, the secretions partially arrested, and the vegetative functions impaired in pro- portion to the severity of the disease. In the fourth stage, the various functions are restored, and excretion estäblished-it is convalescence. Whether a fever lasts a day or a month, it has these symptoms, with addi- tional ones showing a wrong of the blood. + The treatment suggested is very plain. In the form- ing and cold stages means to increase the life, and espe- cially to stimulate the nervous and vascular systems 1 STUDY OF DIAGNOSIS. 351 In the hot stage, to reduce the frequency of the pulse, the temperature and excitation of the nervous system, and to increase excretion and the vegetative functions, employ such means as will check destruction of the blood, or that will neutralize any morbid element in it. LOCAL DISEASE.-Local disease is determined by the unpleasant sensations in the part, experienced by the patient; by change in its functional expression; and by an examination with our senses. and the application of any instrumentality that medicine affords. The distinction between functional and structural disease is determined by the careful examination of the physician. In functional disease we expect to find little or no change in the physical properties of the part; in structural disease such changes will be de- tected THE BRAIN,—Disease of the brain is shown by un- pleasant and painful sensations experienced in the organ, a change in the expression of the face and body, and changes in its functional expression. The charac- ter of the disease will be diagnosed by symptoms already pointed out. It suggests the use of brain remedies, in addition to a right general treatment. As examples we may name Gelseminum, Belladonna, Pulsatilla, Opium, Bromides. of Potash and Ammonium, Phosphorus, Cypripedium, Camphor, Nux, Quinia, Rhus. THE SPINAL CORD.-Disease of the spinal cord is shown by unpleasant sensations experienced in the spine by the patient, by wrongs of muscular movement, respiration, etc. The same remedies are employed as for the brain, 352 STUDY OF DIAGNOSIS. OF THE NOSE.-Unpleasant sensations in and change in secretion of the nasal mucous membrane. Remedies that influence mucous membranes. PHARYNX.-Sore throat, with unpleasant sensations in deglutition and respiration. The throat can be in- spected and changes of structure noted. LARYNX.-Unpleasant sensations in the part; change in the voice; difficulty of respiration; cough; sputa; and change in the sounds on auscultation. Special remedies, Aconite, Spongia, Antimony, Collinsonia. BRONCHIA. Unpleasant sensations in the thorax; difficult respiration; cough; sputa; and change in the sounds heard on auscultation-blowing. Treatment will be general, and remedies that influence mucous membranes. LUNGS.-Unpleasant sensations in the thorax; diffi- cult respiration; cough; sputa; sounds heard in aus- cultation-crepitant; percussion gives dullness when consolidation has taken place from any cause. Reme- dies, Aconite, Ipecac, Lobelia, Drosera, Agrimonia, Phosphorus. HEART.-Unpleasant sensations in the præcordia; sense of oppression and impending danger; change in the pulse; and impairment of the circulation. Special- remedies, Veratrum, Aconite, Digitalis, Cactus, Pulsa- tilla, Rhus, Bryonia. PLEURA.-Pains of a sharp, lancinating character difficulty in inspiration; cough; no change upon aus cultation except in rare cases; dullness on percussion from effusion. Remedies are all general, unless we ex cept Bryonia and Asclepias. STUDY OF DIAGNOSIS. 353 MOUTH AND SALIVARY GLANDS.—Unpleasant sensa- tions, especially on taking food; on exposure structural lesions can be seen and felt. Special remedies, Mer- cury, Iris, Podophyllin, Phytolacca, Collinsonia. ESOPHAGUS.-Difficult deglutition. Remedies gen- eral, except for nervous dysphagia, Pulsatilla. TONSILS.-Uneasy sensations in the throat; difficult deglutition and respiration; can be inspected and changes in size and form noted. Remedies, Aconite, Nitrate of Potash. STOMACH.-Unpleasant sensations in the region of the stomach, and impairment of function. Special remedies, Hydrocyanic Acid, Bismuth, Muriatic Acid, Lactic Acid, Pepsin, Hydrastis, Podophyllin, Leptan- drin, Nux, the class of emetics. SMALL INTESTINE.-Uneasiness in the abdomen; im- pairment of digestion; diarrhoea. Special remedies, Bismuth, Podophyllin, Nitric Acid, Hydrastis, Nux, Agrimonia, Epilobium, Aconite, Ipecac, a part of the class of cathartics. LARGE INTESTINE. Uneasiness in the abdomen; tormina; tenesmus; and small, non-fæcal evacuations. Special remedies, Aconite, Ipecac, Aloes, Colocynth, Hamamelis, Collinsonia. LIVER.-Unpleasant sensations in right hypochon- drium, with occasional slight change in form and size; impairment of digestion; and changes in the color of the skin. Special remedies, Leptandra, Nux, Nitric Acid, Sulphur. 30 354 STUDY OF DIAGNOSIS. SPLEEN.-Unpleasant sensations in left hypochon- drium; change in form and position of the organ de- termined by the touch; and impairment of blood-mak- ing and nutrition. No special remedy unless it be the Uvedalia. PERITONEUM.-Sharp, lancinating pain in the abdo- men, increased by pressure, motion or respiration, with small, wiry pulse, if inflammatory. No special reme- dies. 1 SUPRA-RENAL CAPSULES.-But one disease known- Addison's characterized by bronzed discoloration of the skin, gradually increasing, and associated with im- pairment of the vegetative functions. No remedies known. KIDNEYS.-Unpleasant sensations in the lumbar re- gion near spine, in the urinary apparatus below, and in micturition; changes in the urine determined by ex- amination; and an influence upon the nervous system by retained urea-excitation at first, coma following. Special remedies, Gelseminum, Belladonna, and the class of diuretics. 5 BLADDER.-Unpleasant sensations behind the pubes; perineal pressure; difficult and painful micturition; and the presence of its secretion, mucus or pus, in tho urine. Special remedies, Eryngium, Apis, Phosphorus, Hydrangea, Agrimonia, Staphysagria. PROSTATE GLAND.-Unpleasant sensations in the peri- neum; difficult and painful micturition; and an ex- amination externally and by rectum determines change in size and sensibility. Special remedies, Staphysagria Hamamelis, Phosphorus, Pulsatilla. STUDY OF DIAGNOSIS. 355 URETHRA.-Unpleasant sensations in passing water, discharges. Special remedies, Cannabis Indica, Copai- ba, Cubebs, Macrotys, Sandal Wood. * TESTES.-Unpleasant sensations in; changes in size and form. Special remedies, Phytolacca, the Bromides, Pulsatilla, Staphysagria, Phosphorus, Iodine. : OVARIES.-Unpleasant sensations in the iliac regions; change of size and sensibility to the touch; and wronge of the reproductive function. Special remedies, Ma- crotys, Actea, Caulophyllum, Pulsatilla. 1 UTERUS.-Unpleasant sensations in the pelvis ; change of size and form; change of position; change in the menstrual and reproductive functions by the discharges; change in the tissues determined by the touch and by sight Special remedies, Ergot, Macrotys, Caulophyl- lum.. VAGINA AND VULVA.-Unpleasant sensations; by the discharges; and by an examination by the touch and speculum. Special remedies, those which influence the reproductive function; other remedies such as influence mucous membranes, and the general health. ARTERIES.-Changes in the sensation given to the touch, and impairment of the circulation. Special remedies, the same that influence the heart. VEINS.-Change in size, form, course, and in their color. Special remedies, Hamamelis, Ergot, Iron. LYMPHATIC GLANDS. Changes in size, in tempera- ture and in sensibility; with special impairment of the 356 STUDY OF DIAGNOSIS. blood, and of nutrition in some cases. Special reme- dies, Phytolacca, Iris, Stillingia, Alnus, Scrophularia, Iodine, Bromine, Phosphorus, Arsenic. SKIN.-Unpleasant sensations; charges in structure determined by examination. Special remedies, diapho- retics, Arsenic, Phosphorus, Sulphur. EYE.---Unpleasant sensations; wrongs of function. Special remedies, Belladonna, Calabar Bean, Gelsemi- num, Opium, Rhus, Macrotys, Cannabis Indica, Arsenic. EAR.-Unpleasant sensations; wrongs of function. No special remedies. BONES.-Unpleasant sensations; change of form, size, sensibility, and impaired use. No special remedies. MUSCULAR TISSUES.-Unpleasant sensations in move- ment; changes in size, form and sensibility. Special remedies, Macrotys, Apocynum, Bryonia, Sticta, Phyto- lacca, Colchicum, Potasseæ. ARTICULATIONS.-Unpleasant sensations; changes in form, size and sensibility. No special remedies, except possibly Bryonia and Macrotys. CELLULAR TISSUE.-Symptoms of inflammation, sup- puration. Special remedy, Lime. We have passed most of the organs and tissues in review, in order to impress the fact that remedies do act on special parts. Only a few remedies have been named as examples, but the reader is advised to make notes of remedies under the various heads as they come to his notice by reading or experiment. It must prove · **** " STUDY OF DIAGNOSIS. 357 of value in therapeutics, to be able to at once associate a group of remedies with special parts and functions, as hav- ing them thus clearly before us we can better choose the individual remedy applicable to the case in hand. Much more might have been written on this subject, and I doubt not the reader will feel that a more minute exam- ination of local disease would have been profitable. Yet there are many authorities who give this information, and as said before, it is beyond the scope of our work to make this study. Something must be left for each reader to think out for himself, (and this is really the most profitable study), and I have endeavored to point out the way, and give subjects for such thought. The physician who does his own think- ing will always have the largest measure of success, and the greatest pleasure in and from his work. 1 1 INDEX OF REMEDIES. In appending an index of remedies, I desire to point out the prominent indications for their use, whilst reference is made tc the pages where the agents are noticed. With some of the agents this index will be quite a complete study, and as the reader has all the special indications before him, he will be better able to group them together. So in the study of individual remedies, I thought it would be better to so arrange the index that the reader might do his reading with reference to the one agent; or when using it as a work of reference, he would be pointed to the special feature he desired to study. Acids, Indicated by deep redness of tongue and other parts 1 freely supplied with blood,..……………………. Slick tongue…………….. …………………..80, 81, 102 103 In stomachic digestion......... Acid Acetic, Indicated by deep redness, zymosis..............81, Lactic, Indicated by deep redness... Tissues pinched and stringy. Eructations from stomach………………….. Sepsis...... Gastric digestion 271 81, 102 81 143 112 111 272 In diseases of the stomach...... 353 Muriatic, Contraction of tissues.. 65 Deep redness of mucous membranes.. 81 (( and condition of stomach…………………….. 102 Slick tongue....... 103 360 STUDY OF DIAGNOSIS. $ Acid, Muriatic, Sepsis.......... 111 Eructations from stomach......... 112 Hot breath, pungent.………………. 199 " As an epidemic remedy. Typhoid symptoms Pungent heat Gastric digestion.. In diseases of the stomach…………... Nitric, Irritation of sympathetic....... Violet color.......... To influence the temperature... As an epidemic remedy... Whooping cough...... To influence the pancreas Sulphurous, Color muddy or dirty Erysipelatous redness, blanched Dirty tongue... Increased secretion of saliva....... Large pulse, empty..... Mawkish odor from excreta...... As an epidemic remedy... ………………..221, 227 238 263 272 .... 353 65 .82, 103 166 229 ་ ........... - 230 293 83 90 .... 104 111 153 198 breathi 199 227 Zymosis..... Typhoid symptoms..... 231 238 Pungent heat…………………….. Aconite, Illustrating the certainty of medicine....... ……………. .. 273 15 Inflammation of brain...... 62 Effusion, with bright eyes ...63 Constriction about temples... 65 Shrunken face........ 66 Simple increase of color... 78 Vascular excitement.... 79 Constriction and thinning of structures... 84 Elongated and pointed tongue... 95 Contraction of tongue... 106 Eructations from stomach…………………………………. 112 Contraction and irritability of muscular tissue.......... 142 Small pulse...... 153 INDEX. 361 Aconite, Epidemic remedy.... To influence the nerve centers Tongue, redness of tip and edges. Contracted slick tongue.....………. To infinence the pancreas.. To influence secretion....... To influence the kidneys. Frequency of pulse.......... Determination of blood.......... Congestion.... In inflammation…………. To influence sympathetic innervation 227 26. 269 272 293 299 304 31' 322 323 328 344 In diseases of the larynx, lungs and heart………….. 352 In diseases of the stomach and intestinal canal 353 Acetate of Potash, Sensation of fullness without elasticity... 143 To remove bile pigment..... 290 Alkaline Salts, Pallid tongue...... 101 211 102 Acidity of stomach.. Potash, Muscular wrongs Alcoholic Stimulants, Oppressed voice, hollow and unsteady, 174 Small, soft pulse...... Asclepias, Rubeola, measles..... Apis, Surface hot, burning, painful, dry…….. In disease of the bladder. Aralia, A remedy for dropsy. Ammonia, Enfeebled capillary circulation....... Scarlatina...... As an antidote......... As a cerebral stimulant Actea, Pinkish color.......... 153 229 231 354 349 79 229 ... 247 337 86 355 In the treatment of disease of the ovaries........ Arsenic, White line around mouth, dragging down of corners, 85 Tongue large, thick in center, incurved edges..... Dull and opaque skin.... Increased secretion of saliva.. Pinched, contracted tissues. Open, tremulous pulse........ Feebleness of voice...... 103 93 111 ... .... 144 154 174 31 362 STUDY OF DIAGNOSIS. Arsenic, Influence upon the temperature.....…………. Defect in excretion from the lungs..... Anemia of the spinal cord....……………… In the treatment of diseases of the skin... Alnus, In disease of the lymphatic glands.... Apocynum, Fullness of eyes, fullness of face, drawing down of corners of mouth...... Duli eyes and relaxation of face.. : Full eyelids.. 261 297 339 356 356 62 63 ..66, 84 Full pulse, doughy, accompanied by muscular pain... 153 Edema of cellular tissue.…………. Defect in excretion from the lungs......... To increase excretion from bowels...... A remedy for dropsy. .... In diseases of muscular tissue.... Asclepias, In disease of the pleura........ Agrimonia, In diseases of the respiratory apparatus…….... In diseases of the gastro-intestinal canal………….. In diseases of the kidneys...... Aloes, To influence the large intestine....... Baptisia, Deep color, purplish, brown, black.……………………. แ sepsis...... Saliva, viscosity of...... Full pulse, oppressed.. Pungent heat..... Fetor of cynanche. An epidemic remedy. Typhoid symptoms..... 155 297 307 ...... 349 356 352 352 353 354 353 82 103 111 153 165 199 .... 227 238 263 62 ...... 63 66 79 87 106 153 .... .166, 261 Pungent heat, sepsis. Dull, sodden expression of face. Belladonna, Dull eyes, dilated pupils..... Expressionless eyes......... Slow return of capillary circulation when pressure is made upon the skin......... Fullness of tongue..... Dull, colorless eye….……….. Full, oppressed pulse………….. To influence the temperature... INDEX. 363 J Feebleness of voice 174 Spasmodic cough.... 179 Pain in head, heavy, dull, sleepy 203 ...... Pain dull, heavy, full, with sense of functional im- pairment.. 206 An epidemic remedy.... 227 Scarlatina...... In convulsions..... 229 231 To infiuence the skin. 299 To influence the kidneys....... To influence the circulation. A remedy for congestion....... Feeble cerebral circulation... In the treatment of paralysis. In disease of the brain....... In disease of the kidneys... In disease of the eye... Bismuth, Dragging down of corners of mouth........ Elongated and pointed tongue.……………………. Eructations, pyrosis....... 304 317 .... ..... 323 • 337 .343 351 354 356 85 95 112 } Irritation of stomach 269 Excess of gastric juice...... 271 Intestinal dyspepsia....... 272 To influence the pancreas...... 293 In diseases of the stomach and small intestine............ 353 . Bitter Tonics, Relaxation of tissue......... 143 Defect in electricity…….. 265 Want of expression....... Absurdity in prescription...... Intestinal atony. 267 270 273 Want of appetite. 277 Bryonia, Constricted tissues. 65 Right eyebrow drawn down, flushed right cheek....... 66 Pain, excited circulation...... 69 Deep flush of right cheek...... 86 Venous obstruction....... 7S Sharp stroke of pulse, even vibratile current...... To lessen the temperature……………. 154 168 " 364 STUDY OF DIAGNOSIS. Bryonia, Cough points at supra-sternal notch... ..... Pain in right side of head, passing from before back- ward........ .... Pain, with sense of oppression..... An epidemic remedy.... Excess of temperature………. Wrong in combustion...... To influence excretion from the lungs To influence excretion from the skin.......... In the treatment of inflammation In diseases of the respiratory apparatus...... In diseases of the articulations........ Beeberina, Brownish discoloration of skin.... Bromides, Scanty secretion of saliva..... In diseases of the testes...... .... To influence the lymphatic glands...... 178 203 205 221, 227 260 261 297 299 ... 329 .... 352 356 92 .... 110 355 ... Bromide of Ammonium, Sudden cry, with sobbing respira- tion...... Spasmodic cough... In disease of the spinal cord. In the treatment of paralysis....... In the treatment of spinal irritation....... In diseases of the brain...... Bromide of Potash, A remedy in delirium tremens….. Carbolic Acid, Blanched appearance in inflammation In spinal irritation……….. In disease of the brain. Dark coating of tongue.... Fetor of putrescence…………………………... Camphor, In disease of the brain........ In delirium tremens.... Caulophyllum, In disease of the ovaries Cactus, Præcordial oppression……………. Irregularity of pulse, wrong of stroke....... Cough pointing at supra-sternal notch...... Morbid sounds from the heart.........……. ……………………. To influence the temperature... To influence the pancreas….. 356 175 179 ...... 340 343 347 351 332 347 351 90 104 198 351 332 355 82 154 178 195 261 291 INDEX. 366 Cactus, To influence the skin.………….. ………. In diseases of the heart....... Canabis Indica, In diseases of the urethra.……………. In diseases of the eye...... Calabar Bean, To influence the eyes. Cold feet... Capsicum, Want of power in pulse. In the treatment of delirium tremens... Chloroform, to relieve irritation of the sympathetic nervous system......... Præcordial oppression.... Elongated, pointed tongue. In the treatment of convulsions..... Chloral, In the treatment of delirium tremens... Cathartics, Stimulant, Congestion of brain......... Hydragogue, Effusion into brain……………... Full, broad tongue...... Heavily loaded tongue. Creasote, In scarlet fever..... Chloride of Sodium, Blueness with pallor ...... Increased secretion of saliva..... In scarlet fever……………………. Colocynth, To influence the large intestine.... 297 352 355 356 356 153 169, 263 332 65 82 106 340 332 62 63 95 99 229 82 111 229 353 Chlorate of Potash, Appearance of tongue Increased secretion of saliva.... 104 111 Sepsis......... 165 Odor resembling lochial discharge....... 199 An epidemic remedy...... 227 In puerperal fever............. 231 Typhoid symptoms...... 238 Pungent heat......... 263 Chlorine, Odor of putrescence 195 Chlorinated Soda, In puerperal fever. 231 Cod-liver Oil, Pinched, stringy tissues..... Want of calorifacient food....... 144 169 Feebleness of voice........ 174 To influence the temperature………………… 261 In defective sympathetic innervation.... 344 : 366 STUDY OF DIAGNOSIS. Chloride of Lime, As a disinfociant…………………… 198 Cider, Deep red tongue, dry, contracted, with dark sordes... 102 Collinsonia, In diseases of the larynx Influences the large intestine and rectum ... I Chelidonium, Color dull and opaque...... 352 353 -92 1 Dull, heavy, tensive pain, with occasional twinges, as if the part was being toru..………. ……………. ………. Dull, leaden, yellow fur...... Intestinal dyspepsia.... A pancreatic medicine...... Chamomilla, Gastric indigestion Intestinal indigestion... Charcoal, Excess of gastric juice…...... Columbo, Atony of stomach.…………………… Copper, Sallowness with a tinge of green....... Dull, cheesy-looking fur with tinge of green An epidemic remedy........ As a restorative…........ Greenish pallor of skin.... In Chlorosis..... 10€ 100 273 ... 292 270 272 271 270 92 101 .222, 223 274 277 348 Colchicum, In disease of muscular and fibrous tissue......... 356 Cupping, Congestion of brain………………. Effusion into brain……………... Cypripedium, In the treatment of diseases of the brain Digitalis, Fullness of the tissues of the face..... Dull, leaden color......... Pulse, want of power in impulse..... To influence the temperature.. Frequent pulse…………………... 62 63 351 65. 82 153 261 317 318 ... 344 179 22 229 297 352 ……………………..99, 271 299 Change in the character of the pulse........... To influence the sympathetic nervous system……………………. Drosera, Spasmodic cough......... Whooping cough..... Measles, ་་ To influence excretion from the lungs..... In diseases of the respiratory apparatus... Emetics, Heavily loaded tongue at base…………………….. Erecthites, In excessive secretion from skin...... INDEX. 367 Erigeron, Passive hemorrhage……….. To influence secretion from the skin...... Ergot, Fullness of eyes, face, prominent veins... Passive hemorrhage……………………………. 115 299 62 115 Feeble voice, sighing respiration...... A remedy for congestion……….. Slowness of pulse.......... In the treatment of paralysis........ 174 304 318 343 In disease of the spinal cord......... To influence the uterus.... Electricity, To influence the temperature... 347 355 261 Epilobium, Intestinal irritation........ 272 In disease of the gastro-intestinal canal.. 353 Eryngium, Irritation of the bladder..... 322 In disease of the bladder........ 354 Gentian, Loss of appetite,........... 270 Inflammation of brain....………. Gelseminum, Bright eyes, contracted pupils, flushed face..... 61 Pain, with evidence of excitation......... Restlessness, with determination of blood..... 62 69 71 Vascular excitement.... Elongated and pointed tongue.…………. Pinched, contracted tissues..... Full pulse, vibratile……………………………. 79 106 142 153 To influence the temperature…..... Sudden, shrill, sharp cry.. Pain, sharp, restless....... Exalted sensibility, arterial throbbing. An epidemic remedy. To influence the skin............. In jaundice...………………. In irritation of the kidneys.. Frequent pulse……………………. In the treatment of delirium...... ..166, 260 175 203 206 227 299 290 .... ...304 317 331 mania 333 convulsions 340 paralysis.......... 342 44 delirium tremens...... 332 ย 368 STUDY OF DIAGNOSIS. Gelseminum, Determination of blood... In hyperemia of the spinal cord.... In suppression of urine........ To influence the sympathetic........ Gallic Acid, Passive hemorrhage....... Helonias, Pinkish color of surface.... Hydrastis, Yellow coating of tongue........ Intestinal dyspepsia....... Eructations feebly acid...... Indigestion....... Tongue full and expressionless... In disease of the stomach...... In delirium tremens.......... Hamamelis, Swollen, relaxed eyelids…………… Color purplish from venous stasis In diseases of the large intestine..... urinary apparatus..... venous system.... Hydrangea, In diseases of the bladder. ... Hypophosphites, Pinkish color of surface....... Dull, leaden color of tongue...…………….. Tissues loose and flaccid…..... Feebleness of voice....... To influence the temperature…………. 322 339 341 347 1:5 86 100 ..... 111 112 269 270 353 332 84 89 353 ... 354 ...... 355 344 86 103 143 174 261 Hydrocyanic Acid, Elongated and pointed tongue, reddened tip and edges..…………………. Acid eructations..... Gastro-intestinal irritation....... In diseases of the gatro-intestinal canal.... Iodides, Scanty secretion of saliva......... ... 95 112 269 353 110 Iodide of Ammonium, Tissues pinched and contracted...... 144 Localized pain........ Iodide of Potassium, Fullness without elasticity. Not when tissues are pinched or stringy....... Iodine, As a disinfectant...... શ To influence the pancreas. In the treatment of delirium tremens…………………………….. A stimulant to the sympathetic...... 206 143 144 ... 198 292 .... 332 347 INDEX. 369 1 Iodine, To influence the lymphatic systein.... Iron, Muriate of, To influence the skin In the treatment of inflammation.... Solid blue color….……………………….. Eyelids full, swollen... 356 300 329 82 84 Blueness of veins........ 87 Tissues loose and flaccid.. Feebleness of voice...... 143 174 • Pain in the back of head, dull, heavy.... 203 ... Deficient sympathetic innervation.. An epidemic remedy. In zymotic disease...... An endemic remedy Defect in electricity As a restorative..... Want of color. Anæmia...... ... Anæmia of the spinal cord..….…….. In chlorosis....... In wrongs of the venous circulation....... Muriated Tincture, Blueness with deep color of tongue 87 แ Iris, Scanty secretion of Saliva...... 90 110 222, 223 231 239 265 273 274 310 339 344 348 ... 355 Deep erysipelatous redness Enlarged thyroid gland In, disease of the lymphatic system....... 356 Ipecac, Excess of color........ 79 White line around mouth with thinning of tissue....... 84 Elongated and pointed tongue... 95 Acid eructations.... 112 Opaque mucus……...... 114 Active hemorrhage………………. 115 To relieve irritation of stomach………………………………. 269 Pinched face.......... 272 To influence the pancreas.. 293 To influence the skin..... 299 Irritation of the bowels………………. In disease of the respiratory apparatus...... In disease of the gastro-intestinal canal.... 322 352 353 370 STUDY OF DIAGNOSIS. Lobelia, General bluish or purplish color from venous ob- struction....... Fullness of eyes and face.......... Want of sympathetic innervation.... Capillary stasis from venous obstruction....... Præcordial oppression and constriction of the chest... Fullness of tongue............ Full and doughy tissues..... 89898 62 65 79 82 106 142 Pulse full and doughy.... Halting voice………………….. Oppressed voice......... 153, 155 174 175 Yielding or tremulous character of sounds from the chest....... 189 Anguish, fear of impending danger.. 204 An epidemic remedy.... 227 In measles...... 229 To influence the temperature………….. 260 Defective excretion from the lungs.. 297 To influence the skin 299 To influence the circulation......... 317 ( "L (( Slowness of pulse...... Congestion.......... In disease of the respiratory apparatus... In the treatment of convulsions...... Lime, As a restorative............. In disease of cellular tissue.... In lesions of nutrition. Lycopus, To influence the temperature.... respiratory function..... skin..... Macrotys, Pain from an excited circulation.. Deep color under the eyes.. Contraction and irritability with pain.... Steady vibratile pulse without wave..... With Rhus...………. …………………. Continued succession of tensive pains...... In determination of blood to the uterus. In the treatment of inflammation......... 318 323 352 340 273 275, 356 314 261 297 299 69 84 142 154 205 203 .... 322 329 INDEX. 371 1 Macrotys, In diseases of the reproductive apparatus.. Nux Vomica, Illustrating the action of medicine. Full, expressionless eyes and face...... Expressionless mouth.............. Pain with enfeebled circulation…..... Unsteady movement, anxious countenance..... Brownish-yellow coloration....... 355 In diseases of muscular and fibrous tissues………………………… ……………… 356 15 65 67 69 72 92 Yellow coating of tongue... Fullness of tongue,.. Influences the temperature.... 100 106 .... Increased secretion of saliva.... Pain pointing at umbilicus......... An epidemic remedy Defect of electricity…… 111 166 203, 205 227 265 Atony of stomach.... 270 Atony of intestine...... 273 To influence the pancreas.... 292 To influence excretion from the lungs...... 297 In congestion.......... 323 In the treatment of delirium tremens.. 332 To influence the brain......... To influence the spinal cord...... In anæmia of the spinal cord………………………………. In the treatment of convulsions.. In the treatment of paralysis. In diseases of the brain..... In diseases of the gastro-intestinal canal Nitric Acid, (See Acids,) Violet color........... Nitrate of Soda, An epidemic remedy... Opium, Pain with evidence of atony Moisture of tongue……….. Small pulse, open, square wave.......……………………… ……………………………………. 153 Pulse soft and open In delirium tremens.....……………………. To influence the brain.......... Oxide of zinc, Gastric irritation........ A pancreatic remedy...... 154 332 351 269 292 337 338 339, 347 341 343 351 353 .... .... 82, 103 222, 223 69 105 372 STUDY OF DIAGNOSIS. To influence the pancreas .. Panax, Scanty secretion of saliva........... Peach bark, Amygdalus, elongated and pointed tongue, red- 110 292 dened tip and edges. Irritation of stomach......... Intestinal irritation..... To improve digestion..... 95 269, 270 272 293 Permanganate of Potash, Erysipelatous redness, blanched... 90 Cadaverous fetor............. Phosphorus, Full, pallid face, waving alæ nasi.….……………………. 198 65 * Unsteady movement.... Eyelids full, swollen, expressionless....... Pinkish color......... Dull and opaque skin Dull, leaden color of tongue...... Moist mouth Feebleness of voice......... To influence the temperature...... Deficient electricity As a restorative....... 71 84 86 93 103 111 174 261 265 273 Want of expression..... 274 To influence excretion from the lungs...... 297 Anæmia....... 310 Bad blood....…………………………… ……………. In disease of the brain.......... 314 To influence sympathetic innervation....... 344 351 In disease of the respiratory apparatus……………. .. 352 In disease of the urinary and reproductive organs...... 354 In diseases of the skin..... 356 Phosphate of Soda, Secretions of the mouth neutral or acid.. 112 Phosphoric Acid, Tissues pinched and stringy........ 143 Potash, As a restorative......... 273 Pallor of mucous membranes, impairment of muscular power 276. In anæmia...... 310 Bad blood.... 314 In the treatment of scorbutis... 349 In disease of muscular tissue……………………………………………………………. 356 INDEX. 373 Polygonum, To influence excretion by the skin………………… ……………… ……………. Phytolacca, Scanty saliva...... Pulse, dull stroke with tremulous wave.. 299 110 154 Mammary inflammation...... 330 In diseases of the mouth and salivary glands... 353 In disease of the testes... 355 In disease of muscular tissue........ 356 Pepsine, Enfeebled digestion... 272 In disease of the stomach........ 353 Podophyllin, Illustrating the action of medicine...... Fullness of the tissues of the face...... 15 65 Cellular tissue full, veins prominent... Full upper lip, pallor Venous obstruction... 66 67 79 Fullness of tissue...... 84 Change in pigment, liver spots.. 92 Yellow coat of tongue. 100 Fullness of tongue.. Moist mouth..... Full, open pulse....... Contra-indicated when pulse is small and wiry.......... 154 Pain in ischiatic notches.... An epidemic remedy.. An endemic remedy Dull, expressionless face 106 111 153 203 221, 227 .... 239. 270 Deficiency of gastric juice………………….. Intestinal atony... 271 273 To influence the pancreas......... To increase intestinal secretion….….…….. 292 293 To increase excretion by the bowels.. 307 In diseases of the gastro-intestinal canal. 353 Pulsatilla, Color dull purple…..... ..... 82 Eyes sunken, contracted............. 84 Sudden dropping of wave of blood as it passes the finger………………….. 154 • Cough points at supra-sternal notch...... 178 Mental rest.... 195 Pain, sharp, limited in location, despondent...... .......... 203 374 STUDY OF DIAGNOSIS. Pulsatilla, To influence the sympathetic nervous systerm To influence the brain.... To influence the heart.....…………………………………… In dysphagia.... To influence the reproductive organs.. Quinine, Full, expressionless face.......... Drooping tissues, expression sad............ Unsteady movement, relaxation of muscles...... Causes dryness of tongue..... 344 • 351 352 353 354, 355 65 69 72 105 Moist mouth......... Tissues loose and flaccid.... 111 143 Soft pulse......... Contra-indicated by hard and wiry pulse........ Feebleness of voice........ Tremulous sounds from chest. 153 .... 154 174 189 An epidemic remedy 227 Periodicity.. Malaria...... A nervous stimulant To influence the brain........ In delirium tremens....... .235, 236, 237 246 265 .....331, .331, 351 332 As a remedy for pain 337 Acid eructations........ To increase the blood.... To influence the spinal cord...... Rhubarb, Elongated and pointed tongue, gastric irritation... Irritation of gastro-intestinal canal..... Restoratives, Want of expression...... Rest, Expression of...... Rhus, Constriction about temples and eyes.... Pinched eyes..... 339 ... 95 112 269 54 273 54 65 66 Pain with excitement of circulation........ 69 Bright flush of left cheek. 85 Bright redness of surface........ 90 Eroded appearance of anterior papillæ of the tongue, 107 To influence the temperature…..... 166 Sharp cry, cry encephalique... 175 Frontal pain, pain in left orbit………….. 203 INDEX. 375 Rhus, Burning pain..... An epidemic remedy……... Zymosis...... An endemic remedy.... Illustrating prescription from single symptoms………………. To influence the temperature.. Pungent heat...... 205 221 231 239- 255 ...... 260, 261 a ...... 263 ... 300 329 delirium..... spinal irritation.... 331 347 351 • 352 eye.... 356 To influence the skin...... In the treatment of inflammation.. แ แ To influence the brain... In diseases of the heart.... Santonine, White line around the mouth with fullness of tissues... Sighing respiration....... Full upper lip, picking at the nose........ Staphysagria, Full, swollen eyelids....... In disease of the reproductive apparatus..... Senega, To influence excretion by the skin... Strychnia, Sighing respiration...... Fullness of tongue..... .... Atony of gastro-intestinal canal... To influence the spinal cord…………….. .... Serpentaria, to influence excretion by the skin ………………………………………….. Stramonium, Constrictive pain, muscular contraction....... Sticta, To influence excretion by the lungs...... 84 174 67 84 354 299 174 106 270 .338, 339 299 206 297 356 93 111 198 261 276 In hyperemia of the spinal cord...... 339 To influence sympathetic innervation 344 In disease of the liver...... 353 " skin........... 356 In diseases of muscular and fibrous tissues Sulphur, Want of pigment, change of color………….. Moist, dirty tongue............ As an antiseptic or disinfectant To influence the temperature……….. Change of pigment........ 376 STUDY OF DIAGNOSIS. Solanum, Congestion of the kidneys.... Sinapis Alba, Atony of stomach........ Sulphite of Soda, Erysipelatous redness....... Pallor of tongue, with dirty coat.... Dirty tongue.…………. Viscidity of saliva.... Large, empty pulse........... To influence the temperature..... Mawkish or sweetish odor.. An epidemic remedy..... Zymosis ... Typhoid symptoms..... Heavily coated tongue ..... 304 270 90 83 104 111 ... 153 165 199 227 231 238 271 Sulphurous Acid, (see Acid Sulphurous.) Sulphite of Magnesia, Dirty tongue, redness natural.......... 104 Sedatives, Dryness of tongue Silica, Dullness of epithelium, desquamation....... Soda, An epidemic remedy…... As a restorative...... Anæmia..... Bad blood......... .... 105 276 227 275 310 314 230 ...... 62 65 78 79 90 Trifolium: Pratense, Paroxysmal, spasmodic cough...... Veratrum, Inflammation of brain..... In disease of atony..... Color, simple excess of........... In disease of thoracic organs……………………… Bright redness, arterial throbbing.... Elongated and pointed tongue, evidencing vascular excitement in the brain Glairy, tenacious mucus...... Active hemorrhage..... Or Aconite....………………………. ……… …… Tissues pinched and stringy Full pulse, with strength..... Influence of large dose..... Cough....... An epidemic remedy.... Zymosis. 106 113 ....... 115 142 144 152 163 178 227 231 INDEX. 377 Veratrum, An endemic remedy....... To influence the temperature. A pancreatic medicine...... To increase excretion from the lungs.... To influence excretion by the skin... Frequency of pulse........ In determination of blood... A remedy for inflammation In the treatment of delirium tremens. Hyperæmia of the spinal cord.. In the treatment of convulsions.... spinal irritation...... In diseases of the respiratory apparatus... ī 239 261 292 296, 297 299 317 322 328 ..... 332 339 340 347 ... 352 ... Wet Sheet Pack, In simple increase of temperature…........... 167 32 : INDEX. 19 50 310 19 • Apoplectic condition of brain 62 Abdomen, pain in.... Acids as remedies... Adventitious sounds.. Egophony... Anatomy applied.. Animals, Study of. Anæmia. ..... Applied anatomy......... ... 81 69 Bath in temperature..........167 Basis for all schools............256 Blood, condition of the....... 66 193 192 Color from the......... 77 Blueness of..... 82, 115, 308 Pulse waves.... Wave, length of..... 149 150 Circulation of the.... ......244 Condition of the...........244 Appearance sickly………….. 76 Making...... ....273 Arteries..... 355 Excess of 308 Articulations.….…………. 356 Defect..... ....310 Areola......... 83 Bad....... .311 Atrophic irritation... 63 Evidences of. 313 Auscultation....... 184 Sepsis of......... 312 .... Stethoscope... ...184 Exudates from 312 ... Healthy sounds in chest.185 Circulation of.. 315 Study in English...... 186 Physics of....... 186 Morbid sounds. 186 Blowing sounds..... 187 • Plowing and moist. 188 Tremulous sound..... Irregular distribution of318 Determination of.........320 Evidences of determina- tion of...... Examination of... 189 Black vomit...... Sounds from cavities………..190 | Blowing sounds.... ... 190 Bladder......... Small......... Dry.... ... 190 Boquet Crepitant sounds..... ... Broncophony. Egophony....... Pectoriloquy ... 191 Books, advantage of………….. ...192 Bowels.... .... 321 .... 112 113 187 .354 45 ... 23 135 156 192 Body thermometer. 192 Bowels, liver, percussion of..183 Excretion from the.......306 Of the heart.... Adventitious sounds......193 Bones..... 193 ...356 Of the fœtal heart.........195 Brain, condition of the. 61 .... .... INDEX. 379 Brain, Congestion........ 61 | Classification, nosological....348 Determination of blood. 61 Condition of the sympa- Apoplectic condition..... 62 Inflammation…………………. Effusion Nutrition.... 62 thetics.. 65 Condition of the blood......... 66 63 Convulsions, symptoms of….. 74 63 Color of the surface... Softening... 63 ...... From the blood... Atrophic irritation.. 63 Of health………………. 64 75 77 77 Functional activity.. Innervation from.. 250, 330 Pain, condition of...337, 351 Brown color..... 91 Broad and full tongue......... 95 Broad and pallid tongue………….. 101 Brown and black fur... .104 Broncophony...... .192 .....138 Cadaverous fæces......... Capsules, Supra-renal......... 354 Cardiac wrongs, Color from. 89 Cavities, Sounds from......... 190 Certainty Cerebro-spinal meningitis...232 Cells, Secreting.... Cerumen... Cellular tissues......... Of mucous membranes.. 77 Pigment of health........ 77 Transparency and clear- ness........ Excess of ... 78 78 Capillary circulation.... 79 Effacement of.............. 79 Venous obstruction....... 79 Defect of..... 80 Deepening of...... 80 Dark red..... 80 Typhoid...... 80 Unyielding... 81 24 An evidence of sepsis... 80 Deep redness…... 81 ..283 Acids as remedies……...... 81 295 Dull purple 81 356 Blueness 82 Violet...... 82 30 Deep purplish brown... 82 Muddy 82 Local 83 83 83 87 87 Children, Better diagnosis with. .. Childbirth, Expression in..... 59 Change of form of tongue 94 Cheesy sputa............... ..114 Changes of kind of tempera- ture....... Chest, Healthy sounds from..185 Chronic disease, Epidemic .. .170 influence in...............223 Change of type in disease.....224 Chicken-pox, Varicella.......229 Cholera...... Character of normal secre- 232 tion from skin.... ..301 Changes in the character of the pulse.......... Of the areola of the nipple..... Under the eyes.. Of conjunctiva.. Of bright red..... Of deep red................. 88 Of purplish.......... 88 From cardiac wrong..... 89 Erysipelatous redness... 89 Pigment.. 90 แ Excess............ 90 Transparent.... 90 ....318 ....348 (( Local excess.... 91 (( Deep........ 91 แ Brown 91 tr Greenish yellow$2 Dull & opaque. @2 " Chlorosis....... Clay-colored fæces.............137 Clinical examination urine...130 Cleanliness.....………………………………………………. 197 Classification, general... 217, 220 Bright yellow.. 92 380 STUDY OF DIAGNOSIS. " Color, pigment, greenish..... 92 | Dessicated mucus….............,114 Tallow-like...... 92 Deposits, urinary..... Dirty...... Table of urinary..........134 (L 93 แ Want of......... 93 Deficient fæces.. Of fæces...... Coatings of tongue.. ... Yellow..... Dark... Contraction of tongue. ..137 Deposits......... .129 ..136 .........279 ..280 ...... 97 Degeneration.............. | .....100 100 Defect in secretion..............299 ...104 In excretion from lungs, 297 106 Of the blood................310 .176 Determination of blood......320 Cough.... Expresses irritation 176 Delirium .331 Dry, ringing... .177 Forcible....... .177 Delirium tremens.......... Diagnosis, study of…………..... .331 9 Strength. ....177 Short, sharp, hacking...178 Anatomy necessary in... 20 Methods of. 28 Points.... .178 Spasmodic......... 179 Contagious diseases. ..227 Better with children..... 30 Use of the senses in...... 48 By the eye...... 49 Condition of the blood. ...245 By the touch…………. ..139 Of the tissues.... ....278 By the ear.. ...171 Congestion..... Of the kidneys. Evidence of………….. 303 Physical..... ...179 Constipation...…….. …………………..137, 306 Disease not an entity........ 12 61, 320 ...321 Convulsions....... 339 Intrinsic..………… 340 Extrinsic.... .341 Cord, spinal....... ......351 Cry of pain........ 43 Encephalique…………………………. .......175 Cu'tivation of the senses...... 38 Dark red color.. Dark coatings.. Dark brown fæces... Dead, awake, asleep. use..... 80 ! 104 Development of senses by Expressions of…………......... 14 Relation between reme- dies and....……. Varieties of color in...... 42 Evidence of local......... 58 Local........... Temperature in chronic 160 Voice expresses. Laryngeal, voice changed by.......... 137 Diseases, classification of......211 25 34 53 Decumbence………………….. Depression or excitation..... 55 Determination, expression of 69 Degeneration, expression of.. 70 Defect of color.... 80 Deepening of color. Deep redness, associated with asthenia................... 81 Deep purplish-brown.......... 82 Deep color. 91 80 | Change of type in......... 224 Disuse, senses lost by.......... 35 Dirty color………………….. Dirty fur.... 93 .103 Discharges, examination of..108 Disinfection...... .......... 198 Distinction and definition of disease........ ........209 Digestion, intestinal:.......... 272 Distribution of blood irreg- ular..... Diabetes………... 318 349 15 ...... 66 Range of temperature in 159 Cause of....... .........165 .173 ..176 Contagious.... .227 INDEX. 381 Doctrine of Rademacher......222 | Examination of blood.... Dryness of tongue......... Dry, ringing cough. Dropsy.. Dull purple color Dull and opaque color .105 Eructations ... ..177 .349 81 92 Dull, elastic stroke of pulse..150 Dullness on percussion........181 Ear......... ...356 Vomiting... Black Vomit....... · Of discharges from res- piratory tract....... Mucus, thin, glairy. Mucus opaque..... Globular sputa........ Cheesy sputa…………….. Dessicated mucus.. ..... 112 ......112 112 113 .113 .......113 113 114 ...114 14 Pus....... 114 63 Blood...... .115 71 Mucus streaked with blood....... 115 Exudative material….....116 Of the urine...... Objects of. 116 ... .118 130 132 ..135 .202 .301 304 Education of the senses....... 32 Educated nose…..……. ……………………. ..45, 196 Effusion...... Effort for rest. Effacement of color............ 79 Elongated & pointed tongue 95, 106 Elements of disease, first...... 13 Empty pulse..... Emotion .151 334 .186 9 Entity, disease not an......... 12 Encephalique cry…………………………………..175 English, study of ausculta- tion in...... Equalizing the circulation...319 Errors from nosology..... Eructations, examination of.112 Expression of the mouth...... 67 Provokes function........ 68 Of disease......... 14 In the Horse...... Law of....... In Childbirth...... In the face.... Facial........ Of determination...... In motion.......... Clinical of urine... Of the sediment.. Of the fæces.. Care in....... Of the urine..... ... Excess of the urine..... Of the excretions from the bowels......... ..306 Of blood..... 29 ..308 Of color pigment......... 90 Of color pigment local.. 91 In secretion from skin...298 51 Exaggeration by the sick.... 29 57 By the nurse……….... 58 Excitation or depression...... 55 58 Extension, flexion.... 60 Excretions, odor of.............199 From lungs, defect in...297 From the bowels..........306 From bowels, excess of..306 Perversion of the...... ... 69 70 Of degeneration............ 70 Of the voice..... voice………………………………………… 172 73 .307 Expresses disease............... 173 Exudates from blood..... .312 Examination of tongue....... 93 Extrinsic convulsions.. 110 Of the discharges.........108 Discharges from nose....109 Discharges from mouth..110 Saliva increased...... Saliva, reaction of......111 Of discharges from the stomach........ ......112 ...341 Evidence of local disease..... 58 Determination of blood.321 Of congestion....... ....321 .313 Eye........ 356 Diagnosis by the.......... 49 Color under the………….. Of bad blood….. 83 382 STUDY OF DIAGNOSIS. Facial expression 60 | Health, color of pigmer 71 Favoring the affected part... 72 Hemorrhage Fæces, examination of Increase of Fluid....... Deficient..... Color of..... Dark brown. Greenish.... Clay-colored. Fetor of....……… Cadaverous... Odor of........ Feebleness of voice ... ... .... .....127 135 Healthy standard of temper- ature......... 136 136 Health, range of tempera- 136 137 ture in..... 155 ...158 137 Healthy sounds in chest......185 137 Heart, auscultation of the.... 193 Foetal, auscultation of...195 137 Heat from inflammation 138 Hemiplegia.... 138 Heart........ 325 ...342 .........352 200 Huxley, method of...... 22 .174 30 63 ...322 Foetal heart, auscultation of.195 First elements of disease... 13 Five senses .. Imagination …….. Irritation, atrophic.......... 36 Irritation. 182 147 161 163 95 Indications for quinine...…….. 154 73 Inflammation and fever,tem- perature in..... Influence of sedatives. Increased frequency of pulse3! S Inter-wave current-pulse....151 Inflammation..………………. 62, 323 Symptoms of......... 324 Resolution of.. Fissured tongue... Flexion, extension..... Fluid, dullness from. Forcible cough……………………. Form, recognition of......... 42 Frequency of pulse…….... 146 Increased. ......316 Functional activity of brain. 64 Function, expression pro- vokes...... Full and broad tongue........ 95 Fur, dirty tongue.... Fullness of tongue........ 68 Pain from. Heat from. Swelling from 103 ....106 Full, systolic wave of pulse.151 324 .325 ..325 325 Redness from..............326 Wrong of function from326 Full pulse.... Gangrene....... Glairy, thin mucus Globular sputa. .... Glands, intestinal..... ...151 Danger to the life from.326 Innervation ……………. ..330 .327 From the brain... ..330 • 113 Insanity... 333 114 Intrinsic convulsions.. 340 292 353 137 Large... • • 119 Intestinal digestion.. 281 Irregular temperature...... .353 272 292 .169 Greenish yellow color......... 92 Grayish or yellowish fur......107 Gravity, specific........ Greenish fæces..... Growths. .. Innervation, sympathetic....343 Intestine, small..... Glands.... Distribution of blood....318 151 Irritation, spinal................344 151 174 Hardness of pulse..... Hard, small pulse... Halting voice..... Hacking, short, sharp cough.178 Hearing... 42 Kidneys, condition of...303, 354 Knowledge, source of.......... 17 Senses the source of...... 32 INDEX. 383 Law of expression..... Larynx....... Large intestine... Lesions of nutrition. Life, one...... Wrong..... Study of...... 57 | Names, prescribing at……........ 10 352 Nausea…………………….. 353 Names necessary. 67 ..... 214 314 Nipple, areola color of the... 83 Nosology. 207 Errors from.............9, 208 Distinction & definition.209 Useless...... 12 12 13, 16, 17 18 40 Nose..... Living man, study of......... Light...... Lines, white around mouth... 84 Lip, pallid upper... 84 Liver, percussion of. 183, 289,353 Local disease, evidence of.... 58 Diseases... Color Bright red color... Excess of color.. Disease Lungs, the... 15 Nosological classification.. 348 Educated....………………. 352 .... 196 Examination of dis- charges from the.......109 66 Nomenclature.... Defect in excretion from 297 Lymphatic glands…….. .....210 Nutrition, lesions of...........314 83 87 91 51 Objects of the examination... 118 Odor of the excretions.... 199 • 352 Of the urine 200 ....~ Seminal..... 200 353 Of fæces...... 200 Esophagus....... 353 332 One body, one life. Opaque mucus..... 12 .113 22 Ovaries.... ...355 56, 68, 203, 336 Cry of...... 43 Man, study of the living... 18 Mania, puerperal........ Method of Huxley. Measurement, 24 Methods of diagnosis... 28 Mediate or direct percussion 180 Medical stinks...... .196 Medication, restorative....... 273 Metamorphosis, retrograde..279 Mouth, expression of........... 67 ... .... ... 71 71 White lines around the. 4 Bluish tint around the... 85 Salivary glands............ 353 Movement, rapid.... Unsteady Moistening tongue...... Movements of tongue.... Morbid sounds…………….. Moist, blowing sounds..... Muscles..... Pain From inflammation...... 325 The result of two condi- ...... 6.9 tions....... In the abdomen........... 69 Pallid upper lip............ 84 Pallid and broad tongue..... 101 Palpation...... ....183 Patient, information from...200 Pancreas 96 Paralysis... 291 342 .107 Paraplegia ..343 .186 Percussion... .179 .188 Direct or mediate 180 74 Rules for..... ..180 Object of..... Mucous membranes, color of 77 Muddy color of blood......... 82 Mucus, thin, glairy, opaque..113 Dessicated... Streaked with blood,115,293 | Muscular tissue...... 356 • 114 ... 180 Standard of comparison.181 Normal resonance........ 181 Increased resonance.....181 Dullness..... Dullness from fluid......182 .... 181 1 INDEX. 383 Law of expression... Larynx......... Large intestine... Lesions of nutrition .... Life, one... Wrong... 57 | Names, prescribing at......... 10 352 Nausea.. .... 67 214 353 Names necessary. 314 Nipple, areola color of the... 83 Nosology. 12 12 ..13, 16, 17 207 Errors from.............9, 208 Distinction & definition.209 Useless...... 15 348 352 .... 196 40 Nosological classification.. Nose.... Study of...... Living man, study of.......... 18 Light...... Lines, white around mouth... 84 Lip, pallid upper..... Liver, percussion of. 183, 289,353 Local disease, evidence of.... 58 84 .... Educated...………………. Examination of dis- charges from the.......109 Diseases... 66 Nomenclature. 210 Color ... 83 Nutrition, lesions of ...........314 Bright red color......... 87 Excess of color.. 91 Disease 51 Objects of the examination...118 Odor of the excretions.. .199 Lungs, the... ...352 Of the urine Seminal..... .200 .200 353 Of fæces... Esophagus...... 332 200 .... 353 12 113 ...355 Defect in excretion from 297 Lymphatic glands........ Man, study of the living... 18 Mania, puerperal....... Method of Huxley Measurement. One body, one life. Opaque mucus...... 22 Ovaries..... 24 Methods of diagnosis.... 28 Mediate or direct percussion 180 Medical stinks...... …..196 Medication, restorative....... 273 Metamorphosis, retrograde..279 Mouth, expression of........... 67 White lines around the. 84 Bluish tint around the... 85 Salivary glands....... Movement, rapid...... Unsteady ... Moistening tongue.... Movements of tongue. Morbid sounds...... Moist, blowing sounds.... Muscles.... 353 Pain.... Cry of...... 56, 68, 203, 336 43 From inflammation .. 325 The result of two condi- tions....... ...... 6.9 In the abdomen........... 69 Pallid upper lip............. 84 Pallid and broad tongue..... 101 Palpation...... .......183 71 Patient, information from...200 71 Pancreas .... 96 Paralysis..... 107 Paraplegia ...186 Percussion.. 291 342 343 ..179 188 Direct or mediate ........ 180 .... 74 Rules for..……………… ...180 Object of..... Mucous membranes, color of 77 Muddy color of blood......... 82 Mucus, thin, glairy, opaque..113 ..114 Dessicated... Streaked with blood,115,293 | ..356 Muscular tissue...... ... 180 Standard of comparison.181 Normal resonance........ 181 Increased resonance.....181 Dullness..... Dullness from fluid......182 .... 181 INDEX. 385 ...... .348 Sounds, tremulous Scorbutis.... Senses, education of....... 32 The source of knowledge, 32 Acquired. 33 Developed by use......... 34 Lost by disuse.... From cavities....... Small, blowing...... Crepitant Adventitious 189 190 ..190 35 Sputa, globular...... ... Conscious life thro' the... 36 Cheesy. 191 .193 114 ...114 Five.......... 36 Specific gravity Cultivation of the 38 Spasmodic cough ..132 Use of in diagnosis...... 48 Sediment of urine, examina- tion of............ Spinal innervation......338, 344 Spanæmia. ..119 .179 311 Cord........ 351 Seminal odor..... Secretion. Secreting cells....... 200 Spleen.... 354 282 Study of diagnosis. 9 .283 Of life..... 13, 16, 17 18 ,294 50 52 Secretions, recrementitious. .286 Sebaceous ... 296 299 Excrementitious.. Defect in........... Perversion of...............300 From the skin, excess in,298 Sepsis of blood..... Sensibility........ Of the living man……………………… Of animals.... Objects of... Standard, physiological ... 24 Stomach, examination of discharges from ........ 112 Stroke, dull, elastic of pulse.150 Strength of voice... 312 335 173 Of cough ... ...177 150 150 Standard of comparison Stethoscope.. .181 184 186 ........196 353 Shrunken, pinched tongue... 95 Sharp pulse......... Shock wave………….. Sharpness of voice... .....175 Shrillness of voice............ 175 Short. sharp. hacking cough, 177 Sick, exaggeration by the.... 29 Sickly appearance…………………………….. 76 Skin, regulating temperature by. Slick tongue. • Study of auscultation in English. Stinks, medical Stomach Surgeon, education of......... 17 Surface, color of....... Of pulse wave………………. .166, 356 103 Suppuration ... 75 ...150 327 Slowness of pulse ...............317 Swelling from inflammation,325 Smell....... 44 Sympathetic, condition of... 65 centre, 106 Symptoms of convulsions... 74 151 Systolic wave, pulse full...... 151 151 Symptoms of inflammation..323 195 Sympathetic innervation....343 Small tongue, full in Hard pulse Soft pulse...... Smell, diagnosis by...... Small intestines....... Source of knowledge………... Softening of the brain Sobbing respiration...... 353 17 Taste 63 .175 Sounds, healthy in chest..... 185 Morbid..... Blowing 186 ..187 .... 46 215 Tallow-like color of pigment, 92 Table of urinary deposits....134 Physiological....... Of Dr. Williams......... 216 Temperature...... .155 Blowing and moist…………….. 188 Healthy standard of... .155 386 STUDY OF DIAGNOSIS. } } Temperature, range of in health..... Range of in disease. Relation to pulse...... ..158 159 160 In chronic diseases 160 In fever and inflamma- tion...... Treatment for .... ... 161 162 Influence of sedatives on 163 Relation to functional disease...... ... 164 Tongue, dark coatings......104 Dryness of Contraction of Fullness of...... 105 ...106 ..106 Elongated and pointed..106 Small, full in centre......106 Grayish or yellowish fur, 107 Movements of............107 Touch, the......... 21, 39 Diagnosis by the .........139 In obstetrics.............. 141 Relation of pulse to….....155 A cause of disease......165 Regulation of the skin... 166 | Tonsils...... Baths in 167 Transparency and clearness of color..... Waste of tissue............ 167 Depression of........ Irregular. Changes of kind... Tears...... Testes...... Thermometer, body Registering.. Use of...... Tissues, condition of...... Muscular...... ... 353 78 168 Transparent color of pigment,90 169 Track respiratory, examina- 170 tion of discharges from..113 295 Tremulous sounds on auscul- 353 tation. 156 Typhoid color.... 157 ..158 Unrest .189 80 54 ..278 Unyielding color...... ..356 Uncertainty of information 81 94 94 from patient and nurse..201 Upper lip pallid ... Urine, examination of the... 84 116,301 T'ongue, examination of the, 93 Indications from... Change of form……….... Elongated and pointed.. 95 Full and broad... 95 Pinched, shrunken. 95 Fissured...... 95 Dryness, moisture......... 96 Coatings of .... 97 Coatings, whiteness of... 98 Odor of Heavily loaded.... Coatings yellow. ....100 Coatings, transparent... 98 ... 99 Urinary deposits, table of...134 Wrongs, symptoms of...302 Redness of tip and edges101 | Urethra...... Represents the blood...101 Uroscopy... 355 117 Broad and pallid......... 101 Useless nosology.. 15 Deep red..... 102 Violet colored'…….. .103 Use of the senses in diagno- sis...... 48 Scanty....... Deposits from............129 Clinical examination of, 130 Without visible deposit, 130 Examination of the sed- iment......... ...132 200 ..302 Thick and large.........103 Uterus............……………………… ……………………… 355 Leaden.....………. Slick. ..... Dirty fur...... ……..103 103 Variations of color in disease, 42 103 Vagina and vulva............355 Brown and black fur...104 Venous obstruction.... 79 INDEX. 387 Veins....... Blueness of..... of……………………………. Violet color......... ..355 | Wave of blood..... 86 82 • Colored tongue..........103 Vibratile pulse…..... Vomiting.... Vomit, black..... Volume of pulse. ......149 Blood, length of.........150 Surface of....……………………………………….150 Shock...... ...150 Full, systolic........ .151 Intercurrent………………….. ......151 .........167 ....151 112 113 Waste of tissue • .... 334 173 149 White lines around mou:h 84 Whiteness of tongue... 98 Will, volition....... .........334 Williams Dr., table of ……………….. 216 Wrong life......... .. Volition, will.... Voice, expression of the......172 Expresses disease..... Strength of...... ... .....173 12 Feebleness of......... 174 Cardiac, color from...... 89 Of nervous irritation....174 | Wrongs of function from in- Halting... Oppressed..... Sharpness of... Encephalique….. Shrillness of...... Sobbing respiration. Want of color......... 174 ..174 flammation........... 326 175 Yellow, greenish color of ..175 .175 .175 pigment..........………………….. 92. Bright color of pigment 92 Coatings of tongue....... 100 93 Yellowish fur on tongue......107 Specific MEDICATION SPECIFIC AND SPECIFIC MEDICINES. FOURTH REVISION, WITH AN APPENDIX CONTAINING THE ARTICLES PUBLISHED ON THE SUBJECT SINCE THE FIRST EDITION, AND A REPORT OF CASES ILLUSTRATING SPECIFIC MEDICATION. BY JOHN M. SCUDDER, M. D., Professor of the Principles and Practice of Medicine in the Eclectic Medi cal Institute; author of "The Principles of Medicine, "The Eclectic Practice of Medicine," "The Eclectic Materia Medica and Therapeutics." "A Practical Trea- tise on the Diseases of Women," etc. SIXTEENTH EDITION. Reprinted by request, not revised since 1890. ἐκλέψω CINCINNATI, O.: JOHN. K. SCUDDER 1913. DorM Entered according to Act of Congress, in the years 1870, 1873, and 1880, BY JOHN M. SCUDDER, In the office of the Librarian of Congress. Copyright, 1898, by THE SCUDDER BROS. CO. PREFACE TO THE TENTH EDITION. In this edition the part on Materia Medica has been re- vised, and about one hundred and fifty additional remedies added. We have medicines enough and to spare, and what we need most now is, a thorough study of them to determine their specific indications. The best way for a student, the young practitioner, or any one making a first study of Spe- cific Medication is, to take the remedies marked "My Pocket Case," and learn their use, being guided by single indications. After this one can add to his materia medica as he has need for other remedies, and as he has opportunity to study them. It is very difficult in looking over a Medica Medica like this, to determine the remedies of greatest value, and to distinguish the important from the unimportant symptoms. Each practitioner must make his own materia medica, and the greater the amount of care he gives it the better will it serve his purposes. What I have tried to do in this work, and in the companion volume, "Specific Diagnosis," is to point out the way for these studies, and give such definite knowledge of a number of remedies as will suffice for suc- cessful treatment of the more common diseases of our country. The favor with which these volumes have been received is a proof that the profession has been looking in this direction for a better practice of medicine. CINCINNATI, March 30th, 1880. PREFACE. For some hundred years or more, there has been a pretty uniform agreement in the statement, so frequently repeated— "there are no specifics in medicine." To have a good reputa- tion for professional acquirements and standing, this was a fun- damental article of belief. Whatever might be the certainty in Anatomy, Physiology, Chemistry, and the arts of the Ob- stetrician and Surgeon, it was essential to believe that the practice of medicine was a great uncertainty. That it was a great uncertainty, as commonly followed, we are well assured. The records of disease, the mortality tables, and the resultant lesions from the mal-administration of medicines, abundantly testify to this. This stands confessed in the writings of the most prominent men in the medical profession to-day, who unite in deprecating the use of the older treatment of disease, and the greater safety of the expectant plan-which is really diet and rest. Must we give up medicine entirely? Are there no agencies opposed to processes of disease, that we can employ with cer- tainty? These are the questions of the day, and in answering them, we will decide either for no medicine, or for specific medication. To determine which of these shall be chosen, the reader will have to refer to his own experience of the action of medi- vi PREFACE. cines, and be guided by it. All will admit the uncertainty of medicine, as now used, but no one will be willing to confess that he really knows nothing in therapeutics. I think it will be safe to assert that every practitioner will have the knowl- edge of some antagonism of medicine to disease, that is clear, definite and uniform. If he has but one such, it is positive proof there are others, and the evidence that direct or specific medication is a possibility. Specific medication requires specific diagnosis. We do not propose to teach that single remedies are opposed to diseases according to our present nosology. These consist of an asso- ciation of functional and structural lesions, varying in degree and combination at different times, very rarely the same in any two cases. To prescribe remedies rationally, we are required to analyze the disease and separate it into its component ele- ments, and for these we select the appropriate remedy. The writer has had a sufficiently extended experience in the treatment of disease, to say that he knows absolutely that remedies have this direct antagonistic action to disease, and in many instances he is able to define it so that the reader can readily determine its truth. Still the field of investigation is a broad one, it has been but little cultivated, and there are few careful observers, so that much of the work remains for future investigation. The tendency of medicine in all schools, however, is in the one direction. The giving up of the old uncertainty is the first step, then follows the careful study of individual reme- dies, and their use to accomplish certain well defined objects. One need not be a prophet to forecast the future in this respect. The medicine of the future will very certainly be direct, or as we have chosen to term it, "Specific Medication." PREFACE. vii The object of the author has been to make the subject as plain as possible, and not to obscure it with useless verbiage. The first intention was to tell only what he knew-then this small volume would have been but a pamphlet. But on fur- ther consideration it was deemed best, to point out the lines of investigation with the larger number of our indigenous medi- cines, that they might be thoroughly tested. No apology is offered for its shortcomings. It has been compiled in considerable part, from monthly articles in the Eclectic Medical Journal, and is presented to the profession as a guide in part, but especially as an incentive to the re- study of the Materia Medica. SPECIFIC MEDICATION AND SPECIFIC MEDICINES. THE THEORY OF SPECIFIC MEDICATION. I take it for granted that the reader will concede that all agents employed as medicines act either upon function or structure, and that this action to be curative must be opposed to the processes of disease. This proposition seems so plain that it re- quires no presentation of facts in proof, yet it is well to give it careful consideration, and arrange such facts as may have come under the reader's ob- servation in its support. If the action of a remedy is to oppose a process of disease, evidently its selection will depend-first, upon a correct knowledge of the disease, and second, upon a correct knowledge of this opposition of remedies to it. It is a law of the universe, "that like causes always produce like effects," or to reverse it," that like effects always flow from like causes." There- fore, if we can determine the opposition of a remedy 19 SPECIFIC MEDICATION. 1 to a process of disease in any given case, we have determined it in all like cases. And, to make use of this knowledge subsequently it is only necessary that we be able to determine the exact condition of disease, when we very certainly expect to obtain the same curative (opposing) action from the remedy. In describing this action to another, it is neces- sary-first, that we so observe and group the signs and symptoms of disease, that he may get the exact idea of the pathological condition to be opposed. The skill required is in diagnosis, and necessitates a very thorough re-study of pathology, ignoring to a great extent, our present nosology. To facilitate this study, the author has published a work--“ The Principles of Medicine "—which embodies his views, and will serve as a basis for specific or direct medi- cation. Much that might be deemed necessary in this monograph, will there be found in its proper connection, and we have not deemed it desirable to separate it and reproduce it here. Many persons are in error in regard to our use of the term specific. They think of a specific medicine, as one that will cure all cases of a certain disease, according to our present nosology, as pneumonitis, dysentery, diarrhoea, albuminuria, phthisis, etc.; and a person looking at the subject in this light, and guided by his experience in the use of remedies, would at once say there are no specifics. We use the term specific with relation to definite pathological conditions, and propose to say, that SPECIFIC MEDICATION. 11 certain well determined deviations from the healthy state, will always be corrected by certain specific medicines. A disease, according to our present nosology, may be formed of one, or of a half-dozen or more distinct pathological changes, bearing a determinate relation to one another. We do not propose to reach all of these by one remedy, except in those cases in which one lesion is primary, and the others result from it. But on the contrary, we propose a remedy for each pathological feature, using the remedy for that first which is first in the chain of morbid action, and that second which stands second, and so on. As an example, we analyze a case of fever, and find it to consist of a lesion of the circulation, a lesion of innervation, a lesion of secretion, a lesion of the blood, and a lesion of nutrition; each of these is regarded as a distinct element of the dis- ease, but in the order named,—the one depending upon the other to a certain extent. A remedy that will rectify the lesion of circulation, will sometimes be sufficient to arrest the entire chain of morbid phenomena as we notice in the simple fevers. Or a remedy that will correct the lesion of the blood- this being primary and the cause of the various morbid processes,-will be a specific for all, as when quinine arrests an intermittent or remittent fever. But in the severer types of disease, we find it necessary to use a remedy or remedies for each path- ological feature. Thus, we employ one to correct the lesion of circulation, one to correct the lesion 12 SPECIFIC MEDICATION. of innervation, special remedies to increase secre- tion, to correct the lesion of the blood, etc. Instead of one remedy to arrest the disease, according to the ordinary use of the term specific, we employ a number of different agents, which are none the less specific, for they meet distinct features of the dis- eased action. To employ remedies in this way, it is requisite that we analyze the disease according to what we know of pathology, determining definitely the ele- ments that go to form it, and their relation to one another. And secondly, that we know the direct influence of remedies upon the human body, both in healtu and disease; that we use them singly or in simple combinations; that we do one thing at a time: that first which is first, that second which holds the second place, and so on. If one expects to obtain the advantages of specific medication, he must not associate it with indirect medication. The direct sedatives, with free podo- phyllin catharsis veratrum in pneumonia, with nauseants, blisters, etc., are incompatible. Success comes from one or the other alone. If I use direct medication I use it alone, and if I use indirect medi- cation I use it alone. If we propose to treat a case of croup with Aconite, we do not use nauseants; if we propose to cure a case of cholera infantum with Ipecac and Nux Vomica, we do not want as- tringents. But we go further into the analysis of diseased SPECIFIC MEDICATION. 18 action as expressed by symptoms, than many sup- pose. The success of direct medication comes from the definiteness of diagnosis-determining the exact condition of a function or part. : • To illustrate, it is not sufficient in selecting a sedative to know that the pulse is frequent, using alike Veratrum, Aconite, Digitalis, Gelseminum, or Lobelia. Frequency is but one element of the lesion and we have to determine in addition the strength or weakness of the circulation, the degree of obstruction of the capillary circulation, and the condition of the nervous system that controls this function. Thus, where there is strength with fre- quency we employ Veratrum; feebleness with fre- quency, Aconite; excitation of the nervous system with strength and frequency, Gelseminum; atony of the nervous system and tendency to stasis of blood, Aconite and Belladonna; feeble impulse from the heart, without capillary obstruction, Digitalis, etc. 1 It is not sufficient to know that the tongue is coated, indicating an impairment or arrest of diges- tion. We make this secretion give us the history of blood lesions, as well as of gastric and intestinal derangements. We learn that pallid mucous mem- branes with white coat demand alkalies; that deep red mucous membranes and brown coat call for acids; that a dirty-white, pasty coat requires the alkaline sulphites, etc. It is not necessary to con- tinue this illustration further, for the reader will see by the above that the specific medication requires spe- 14 SPECIFIC MEDICATION. cific diagnosis, and that it will be successful just in proportion as we become skilled in this. It is true that almost any one can use Veratrum and Aconite successfully, for the conditions are so prominent that they can not be mistaken; or any one may successfully prescribe Aconite in sporadic dysentery from cold; Ipecac in the diarrhoea of chil- dren; Collinsonia or Hamamelis for hemorrhoids; Collinsonia for ministers' sore throat; Cactus for heart disease; Pulsatilla for nervousness; Staphy- sagria for prostatorrhea; Eryngium Aquaticum for cystic or urethral irritation; Apocynum Canabinum for dropsy, etc., etc. These remedies have an extra value attached to them, because the conditions in- dicating them are so easily determined. Yet the reader will learn with surprise that ten years since, with but one exception, not one of these agents were used for the purpose named. In 1860, 10 lbs. of the crude root of Collinsonia supplied the market for a year; now one house gets in 10,000 lbs. for the year's supply. SPECIFIC DIAGNOSIS. We have a eady insisted upon the necessity of specific diagnosis if we are to expect definite cura- tive action from medicines. This is a very impor- tant element of specific or direct medication that many physicians do not seem to understand. When we speak of specific medication they get the idea of an absolute cure for disease according to our SPECIFIC DIAGNOSIS. 18 present nosology, and say there is no such thing as a specific medicine. They expect to guess at the name of a disease, and find a remedy that will fit their guess-work. To suit such, a medicine must be like a blunderbuss, scattering its shot all over the field, giving a probability that some will reach the mark. Direct medication, on the contrary, requires spe- cific diagnosis. We must know exactly what the de- parture from health is, and knowing this we may select a remedy which will correct it. As was re- marked before, the physician must have first a thor- ough knowledge of healthy life, and be able to re- cognize it, or any departure from it. Thus Anat- omy and Physiology are the true basis of direct medication, for if we do not know the healthy structure and function, it is not possible that we can know the diseased structure and function. We have a very simple rule for measuring the departure from health, and it is easily applied. It is in one of three directions-excess, defect, or perver- sion—above, below, or from. If we can measure disease in this way, the desired remedial action is at once suggested-if in excess it is to be diminished, if defective it is to be increased, if perverted it is to be brought back to the normal standard. In a majority of acute diseases, we will find these de- partures so clearly marked that the diagnosis and treatment are very easy. But as there are many elements that go to make healthy life in man, so there are many that go to 16 SPECIFIC MEDICATION. make the sum of disease. These will be found in varying combination, yet in most cases there are certain prominent lesions which may be regarded as standing first in the chain of morbid phenomena and upon which the others rest. If we can find remedies which will reach and correct these, the disease is at an end, and the natural restorative power of the body soon gives health. The most simple form of specific medication is where a single remedy is sufficient to arrest the pro- cess of disease. As when we prescribe Collinsonia for ministers' sore throat, Drosera for the cough of measles, Belladonna for congestive headache, Ma- crotys for muscular pains, Hamamelis for hemor rhoids, Phytolacca for mammary irritation, Cactus for functional heart disease, Staphysagria for pros- tatorrhoea, etc. This use of remedies gives great satisfaction in the treatment of many diseases, and we are led to wish that the practice of medicine could be resolved into the giving of such specifics. A Not quite so simple, but yet very plain is the second form of direct medication, illustrated by the following examples. A heavily loaded tongue at base, with a bad taste in the mouth and fullness in the epigastric region, demanding an emetic. uniformly yellowish coated tongue from base to tip, relieved by Podophyllin or Leptandrin. A pallid tongue, coated white, calling for a salt of soda. A pallid large tongue, with a moist pasty coat, de- manding the alkaline sulphites, say sulphite of soda. The deep red tongue and mucous membranes with SPECIFIC DIAGNOSIS. 17 brownish coatings, demanding the use of acids, say muriatic acid. Quite as plain, but not so easily and directly reached by medicine, is the need of a good condi- tion of the intestinal canal for digestion and blood making, and associated with it the recognition of the need of certain restoratives that may be neces- sary to normal nutrition and functional activity. These are essentials in the treatment of every form of disease. In acute cases, it is required first to rid our patient of functional disease before we can fully establish digestion and nutrition, but in chronic dis- ease it will many times stand first, and must always be associated with treatment for local lesions. The complement of this is, treatment to increase the removal of old and worn-out tissues, and thus relieve the solids and fluids of material that must necessarily depress functional activity. Probably we have as little positive knowledge of remedies that increase retrograde metamorphosis, as of any other class, still they are being studied, and in time we will be enabled to use them directly. Remedies that increase excretion are in common use, and form a very important part of our practice. From the earliest periods of medicine, the fact that dis- ease is destructive has been recognized. Destruc- tion of the material of our bodies, necessarily leaves the debris either in solids or fluids, and experience has shown that it can not remain in the body with safety. Hence the common use of those agents 2 18 SPECIFIC MEDICATION. that stimulate excretion from skin, kidneys and bowels. But there has been a failure to appreciate the true nature of these processes, and from this has flowed a very great deal of bad practice. These processes are strictly vital processes, carried on by delicate organisms under the control of the nervous system. As they are the basis of life, we may well suppose that nature has guarded them on all sides, and that they are the true centre of life. The doc- tor of the olden time has looked upon them as mechanisms to be powerfully influenced by reme- dies. He powerfully excites the stomach and intes- tinal canal as a means of derivation, and works upon the skin and kidneys as if secretion from them were a purely physical process. Thousands of lives have been and are being destroyed in this way. Any one who will take up Huxley's Physiology, and read the clear and simple description of this apparatus for digestion and waste, upon which our lives rest, can not but be satisfied that the common practice of medicine is a very great wrong. A man lives, because he has the power of renewing his life day by day. Take away this power and he will die in a brief time; take it away in part, and you have lessened his power to that extent; take it away for an hour, for a day, or for a week, and his power to live is weakened to that extent. When we regard these processes as strictly vital processes, in highly developed organs, under the control of a most delicately adjusted nervous system, SPECIFIC DIAGNOSIS. 19 we will be in a position to use remedies to aid vital action. Studying the condition of the stomach and intestinal canal in this light, we will see how a direct stimulant, or tonic, an alkali, an acid, a rem- edy that will relieve nervous irritation, or one that will give increased innervation, will in different cases be an aid to digestion. Looking farther, we will see the necessity, in one case of histogenetic food, in another of calorifacient, in one of iron, in another of phosphorus, etc. It is just as much specific medication to be able to select the proper food for the sick as it is the proper medicine. One or two examples of this may not be out of place. The past winter I was called in consultation, in a case of continued fever in the third week. The treatment, so far as medicine was concerned, had been very judicious, but the food had been starchy, and for a week the patient had been able to take very little. He was failing fast, and stimu lants and tonics were used without advantage. The most striking features of the disease to me were: the feebleness of the heart's action, the want of respiratory power, and the evidences of a general failure of muscular power-in all other respects the patient was in good condition. I advised enemata of beef-essence, and its internal administration in small quantities frequently repeated, and a suspen- sion of all medicine. The effect was marked in twenty-four hours, and the patient speedily recov- ered. In the early part of my practice I had occa- sion to call Dr. William Judkins in consultation, in 1 20 SPECIFIC MEDICATION. 酱 ​the case of a lady who had incipient phthisis de veloped from menstrual irregularity. She was very feeble, and I had been giving her freely of the bit- ter tonics, stimulants and animal food. The old Quaker remarked, if thee will stop the medicine and stimulants, and give her fatty matter she will recover-and the result justified the old doctor's skill in diagnosis. I have had to take this advice twice in the past eighteen months, from other par- ties, when I should have recognized it myself; in both it was the one thing necessary to success. With regard to excretion, we must be thoroughly impressed with the fact that it is wholly a vital pro- cess, and not a process of straining. When we come to understand that a secreting organ is con- tinually growing secreting cells, and that these withdraw from the blood the worn-out materials of our bodies, we will be in a position to use remedies with better success. Evidently it is possible to so over-stimulate or over-work an excretory organ, that this function of cell-production will be very much diminished or altogether arrested. Just in this proportion must secretion be impaired or wholly arrested. The best remedies to increase secretion are those that act mildly and stimulate vital function. Thus far direct medication is very plain sailing. All can succeed with it, yet successes will be in pro- portion to the physician's acuteness of observation, and to some extent upon his knowledge of remedies. But beyond this we have a field that requires a very thorough knowledge of vital processes, accurate ob DIFFERENCE FROM HOMEOPATHY. 21 servation, and an extended knowledge of remedies. We study not so much the grosser manifestations of disease, but the more delicate shadings and com- binations, and our therapeutics requires that we have a most intimate knowledge of the influence of remedies upon the human body. In this field of study the physician will find a beauty and certainty in the practice of medicine that will give zest to in- vestigation, and as it is pursued he will find greater and greater success. DIFFERENCE FROM HOMEOPATHY. The question has been asked, "In what does your theory of specific medication differ from Homœop- athy?" The question is a pertinent one, and I will endeavor to answer it briefly. The law, similia similibus, upon which the Ho- mœopathic practice is based, is defined in two ways. One contends that the drug, used for cure. "pro- duces the essential morbid condition" when proven in health. The other, "that it produces similar symptoms," but not the exact pathological condi- tion. The truth in this law of similia similibus, 18, that certain agents, called medicines, act on particular organs, parts, and functions of the human body in a uniform manner. They act equally on the organ, part, or function, in health and disease; and thus acting in health, they produce such change in the phenomena of life as to render the action sensible 22 SPECIFIC MEDICATION. to the person-symptoms. If an agent directly and uniformly produces an influence upon a particular part, it is more likely to be used as a remedy in dis- ease of that part than another which does not influ- ence the part at all. Remedies are, therefore, those agents which directly and uniformly influence an organ, part, or function. The question then comes up, are they remedies because "they will produce a similar state of disease," or because they are opposed to diseased action? The Homœopaths will not admit any explanation of their law of similia. The remedy is a remedy because it will produce the exact diseased condition, or at least the exact symptoms of such condition. I contend that a drug is a specific remedy: first, because it influences uniformly and directly the part or function diseased; and second, because it opposes such diseased action. I would, therefore, write the law of cure, contraria contrariis opponenda, instead of similia similibus. I find a late authority in Homœopathy agrees with me in this. Dr. v. Grauvogl, in his "Lehr- buch Der Homoeopathy," says:-"The conception of a specific remedy expresses the mutual relation existing between it and parts of the organism, which has to be ascertained empirically by physio- logical provings of drugs. For some part of the organism is in a relation of immunity, for other parts of attraction, for others again one of repulsion and always vice versa. For instance, there is a spe- DIFFERENCE FROM HOMEOPATHY. 28 ific form of fever and ague which, for these very reasons, is cured by Quinine, a dose or quantity of Quinine being given which corresponds to the in- tensity of the attack." * * Again with reference to the dose of medicines: "All we have to do is to determine, independently of all subjective persuasions and incomprehensibili- ties, what quantity of a substance is necessary in order to produce in any morbidly affected part of the organism a chemical or physical counter-move- ment of equal intensity, and in an opposite direction to the movement originated by the morbific cause, with a view of arresting, or at least, retarding this latter, and finally discontinuing it altogether by re- peating the dose. * The problem is simply to determine what remedial movement quantities will antagonize as their equivalent the movements that had been excited by the morbific agent; for the measure of the force is the effect, nothing else. To solve this problem we have the natural law according to which quantity contains the measure of the movement and counter-move- ment; consequently for therapeutic purposes, the correct dose consists in a quantity of force of the indicated quality which is equal to the quantity of force of the morbific agent, and in its movements runs in a contrary direction to the quality of the latter." In ordinary practice, whether it be Old School or Eclectic, there is no principle or law of cure. Rem- edies are not given because they are opposed to or 24 SPECIFIC MEDICATION. agree with diseased action, but simply because they have been previously used with reputed good suc- cess. It is, in fact, pure empiricism. The old dog- ma of phlogosis and antiphlogistics, and the new doctrine of impaired vitality and restorative medi- cation, guides the empirical use of remedies in the one or other direction. THE ADMINISTRATION OF MEDICINES. We may lay it down as an axiom, from which it is never safe to depart, that-No medicine should be given, unless the pathological condition and the indica- tions for its use are clearly defined. It is much better to employ a placebo, than run the risk of doing harm by medication. Good nursing is an essential element in the suc- cessful practice of medicine, and always requires direction by the physician; keeping the stomach in good condition for the reception of food and medi- cine, is of first importance, and requires attention. Following this is the selection of proper food, its preparation, and the time for its administration These alone very well repay the careful attention and thought of the physician, even if he can not see an indication for the employment of remedies. When we recollect that the cause of disease is always depressing, and a source of constant renewal, we will see that the removal of the cause from the patient or the patient from the cause, or the antag- onism of remedies to remove the cause, is` a proper ADMINISTRATION OF MEDICINES. 25 field for our efforts. If we can see clearly that the condition of disease is one of depression-that in proportion as a man is sick, his vitality is lessened, such means as will increase the power to live, or the resistance of the body to death, will be sug- gested. As we have stated before, we make an analysis of the disease and divide it into its component parts, before making a prescription of medicine. There are certain basic functions or conditions upon which all others rest, and which are essential to life. These demand our first consideration. Thus the circulation of the blood, the temperature, the condition of the nervous system, waste, excretion, the condition of the blood, blood-making and nutrition, are examined separately. Determining the lesion of these, we prescribe such remedy as antagonizes it, and brings the function toward the healthy standard. Some one of them will stand first in the series of patho- logical changes, and will serve as a basis for others, and this will receive first attention. Thus we pre scribe at the other lesions, in the order in which they seem to be arranged. We As a rule, it is best to do one thing at a time. prescribe first for that lesion which is first in the chain of morbid action. Then maintaining the in- fluence obtained by a continuation of the remedy, we do that second which is second, and that third which is third, and so on. In the cure of disease time is an important ele- ment, and it is never best to be in a hurry. Here, 3 26 SPECIFIC MEDICATION. the old proverb "haste makes waste," is a very true one. As a rule, the severer the disease, the slower its development; the slower the departure from health the greater the impairment of function and structure, and necessarily the slower its restora- tion. The manifestations of life in man are from a highly developed organism, the perfection of which is a work of time. Every manifestation of life ne- cessitates a continued renewal of structure, requir- ing an expenditure of that force we know as vital. Therefore, when the manifestations of life are ab- normal (disease), we must necessarily allow time for the development of the organism, increased because the vital force is impaired. As a rule, it is best to change the manifestations of diseased life slowly, giving sufficient time for the or- ganism to adapt itself to the change, and gain in- creased strength as it returns to the condition of health. It will never do to suppress a process of disease at the risk of suppressing the organism upon which natural function depends. As a rule, it is best to effect these changes insensibly, or without shock to an organ or to the entire body. In this, as in all other things, it is the slow but con- tinued application of an opposing force, that ac- complishes the greatest results. Many thousands of sick have been hurried to their graves by the sudden and forcible efforts of the physician to re- move disease. This is one of the most prominent THE FORM OF MEDICINE. 27 errors of the old practice, and will require consid- erable effort to avoid. As a rule, it is best to employ remedies singly, or in simple combination of remedies acting in the same way. The reasons for this rule are obvious. It prevents random or scattering prescriptions. We either know a single remedy that will accomplish the ob- ject, or we know nothing and have no right to make a prescription. There can not be anything in a combination that is not in the individual articles composing it, and in some one of them par excellence: this is the remedy to use. In direct medication we want no modifying influences; we want the plain and constant action of a simple remedy. THE FORM OF MEDICINE. The common action of many medicines obtained in the old practice is the poisonons action. The agent is given in such large doses and is so nauseous, that the human body in self-preservation is forced to act upon and expel it. Thus, an emetic forces. the stomach to an act of expulsion, and we have emesis; a cathartic influences the intestinal canal in like manner and we have catharsis; and. with diaphoretics and diuretics. A different class, which may be represented by mercury, antimony, and arsenic, obtain entrance to the blood, and depressing this, they depress every manifestation of life until they are finally slowly removed. If we desire to obtain these grave influences of 1 28 SPECIFIC MEDICATION. medicine, the form is not particular, neither is the size of the dose-if the patient can stand it. But if we desire that slow, insensible, but direct action that I have spoken of, we want our remedies in such form that they will be kindly received and have a kindly action upon the organism. We have also to take into consideration the pre- servation of the article, uniformity of action, pleas- antness to the sick, portability, and ease of pre- scription. These hold a secondary place, yet are very important. A class of remedies may be regarded as chemicals, and these we desire in greatest purity, and only purchase such as bear the names of the best manu facturers. Such are Quinia, Morphia, Sulphite of Soda, Phosphate of Soda, the Bromides, etc. The largest class is obtained from the vegetable world, and are products of nature's laboratory. These we wish unchanged by art, as nature has prepared them, simply reducing the bulk, and using a vehicle to preserve them. Very certainly the best menstruum for all vege- table remedies is alcohol and water in varying pro- portion. There is no vegetable product that does not yield its medicinal properties to these, in a very concentrated form, the alcohol being in sufficient proportion for preservation. Not only so, but with modern apparatus for percolation, the fluid may easily represent the strength of ounce for ounce, giving sufficient concentration to make it portable. The tincture thus prepared is miscible with water, THE FORM OF MEDICINE. 29 which is undoubtedly the best vehicle for the intro- duction of a remedy into the blood. In using a hypodermic injection, we employ water as a vehicle for the medicine, and not simple syrup, syrup of lemon or ginger, an extract of quassia or other nasty substance, and so in introducing remedies into the circulation, through the stomach, we will find water decidedly the best vehicle. Remedies in pura naturalibus are not offensive, it is the covering them up, and mixing them that makes them unpleasant. Doctors' potions are pro- verbially nasty, and the public mind has been culti- vated to believe that a mixture in a bottle must be an offence to smell, taste and stomach. The thoughts of such medicines are enough to make some sick. My prescriptions are uniformly made with water as a vehicle, the tincture being added to it in such proportion that the dose will be a teaspoonful. If the tinctures are carried in the pocket case, we add them to a glass of water in proper proportion, and renew the medicine at each visit that it may be fresh. In the treatment of diseases of children this ex- temporaneous dispensing is especially desirable. Children are naturally adverse to anything un- pleasant, and one ordinary drugging is sufficient to "put them agains. medicine." It is very unpleasant to be required to for, e medicine upon a child against ts wishes, still more to throw it down, hold it for- cibly, and grasping its nose make it swallow the ; 80 SPECIFIC MEDICATION. mixture. No wonder parents turn from such prac tice to Homœopathy. It has been my practice to have the little patient see all the operations of preparing the medicine. It sees the pocket case, inspects the bottles, and is convinced that everything is clean and there is nothing objectionable. The glass of water is placed before it, and the few drops of medicine added, and to the request, "My dear, taste this and see if the medicine is not good," it offers no objection, is sat- isfied, and you have obtained the little patient's confidence, and will never lose it until you abuse it. THE DOSE OF MEDICINE. As a rule, the dose of medicine should be the smallest quantity that will produce the desired result. The proper dose, or that which gives the best result, is very much smaller than one who has been used to the large doses of indirect medicine would suppose possible. Yet it is not infinitesimal, as our Homœo- pathic friends would have us believe. It is difficult to state what the dose should be as yet, but I be lieve those named in connection with the remedies are the maximum. A few examples may serve to illustrate this. In the olden time we thought the dose of a strong tincture of Macrotys was from half to one teaspoon- ful, repeated every two or three hours, until "the head felt like bursting." I now find the remedy much more certain in the proportion of 3j. of the 1 REPARATION OF REMEDIES. 81 tinsture lʊ water 3iv. a teaspoonful every two hours. The common directions for using Veratrum (Nor- wood's Tincture) were to commence with a dose of three drops every three hours, increasing one drop each dose, until its full effect was produced. Now the dose is always less than one drop. Aconite was formerly given in doses of drops, now in fractions of drops. The dose will vary in different cases, and with different practitioners. If it falls below the gross or poisonous action of the drug, it will have specific influence, and the diagnosis being right, will accom- plish the object of the prescriber. I am satisfied that the size of the dose does not make such differ- ence as has been thought, and that the essential element of success is to get the right remedy. THE PREPARATION OF REMEDIES. The majority of physicians will prepare but few remedies themselves, yet it is just as essential that they know how they should be prepared, as if they made them all. With an intelligent understanding of the simpler processes of pharmacy, he will have a much better knowledge of the physical properties of medicines, and be enabled to judge somewhat of their purity and efficiency when purchasing. The general drug trade has been a miserable fraud upon the profession. Whether selling crude or manufactured articles, the chances were ten to one that they were adulterated, and not what they 82 SPECIFIC MEDICATION. were represented, (Morphia, Quinia, and some of the common chemicals, have been exceptions.) So far has this sophistication been carried that all certainty in medicine, even in gross drugging for indirect effect, has been lost. Solid or fluid ex- tracts are found of all degrees of strength, from the highest named in the pharmacopoeia to nothing. In many cases they are prepared from old and worthless crude material, that has partly or wholly lost its medicinal properties, yet it is sold in the same packages and at the same prices, as if good. There is but one safe plan for the physician in procuring remedies, and that is by personal experi- ment to satisfy himself that a good remedy can be readily prepared, and learn to know it when he sees it. Deal with houses that claim to prepare remedies from recent crude material, of full strength, without heat, and return every package that does not come up to the full standard of strength and excellence. It is well to adopt a simple nomenclature for fluid medicines. Let them be called tinctures, as they are prepared with alcohol, and specify the strength ounce for ounce, of crude material to fluid preparation. I insist that all vegetable remedies should be pre- pared from the recent crude material obtained at its proper season. In some cases the remedy does not materially deteriorate within the year, and may be kept in stock until the next season for gathering. But in all cases it is better if prepared at once after gathering, and in many the preparation should be PREPARATION OF REMEDIES. 88 from the fresh article before any dessication. The reasons are obvious-the medicinal properties are found in the juices of the plant, or stored in its cells, principally of the bark. In both cases drying removes the medicinal principle, to a greater or less extent. The medicinal principles of plants are to a considerable extent complex and unstable organic bodies, and time, with its constant processes of change and decay, changes, deteriorates, and finally destroys them. STRENGTH OF FLUID REMEDIES. As before re- marked, a remedy is desirable in proportion as it is easily carried and dispensed, (leaving out of the question its medicinal action), hence concentration becomes an important element of pharmacy. A skilled manufacturer who has the proper appliances, has no difficulty in removing all the medicinal prop- erties from vegetable products, so that one Troy ounce of crude material will be contained in one fluid-ounce of the tincture. This may be accomplished by the simple process of percolation, in most cases. In some pharmacies this is supplemented by powerful pressure; in other cases, the hydraulic press being employed with ad vantage. In other establishments, the new process of percolation under atmospheric pressure, has been adopted with great advantage. Either of these methods if carefully and honestly conducted will give reliable and uniform remedies. If we can make up our minds that it is quality, rather than quantity, that we should look after, slight variations 34 SPECIFIC MEDICATION. 1 of strength will make but little difference. I do not wish to be understood, however, as admit- ting that there can be any great variation of medicinal strength, if recent crude material is used, and the product represents ounce for ounce, and the pharmaceutical processes have been skillfully conducted. PHYSICAL PROPERTIES OF FLUID REMEDIES.-The fluid preparations should possess the exact physical properties (intensified), as regards odor and taste, of the fresh crude material. It will have the color of the chlorophyll of the article, but should be clear and transparent, and give no sediment, or muddiness when shaken. These may seem like minor matters, yet we will find it profitable to give them attention. Skilled pharmacy gives fine look- ing remedies, and they are likely to be good. Un- skilled pharmacy gives dirty-looking preparations, and they are likely to be inferior. We may judge to a considerable extent of the goodness of chemicals in the same way. If we find our Sulphate of Quinia and Morphia presenting the clear white silky or feathered crystals, we are satis- fied that we have good remedies. But if it is dull, discolored, crystals faint, broken, or amorphous, we want none of it. So in the purchase of the Bro- mides, Iodides, Salts of Potash and Soda, Iron, etc., we expect to find the highest physical qualities, associated with purity and efficiency. If a salt is discolored, or in any wise deficient in its appear- ance, we want none of it. OFFICE PHARMACY. 85 OFFICE PHARMACY. There are good reasons why every physician should have such knowledge of pharmacy, that he can perform or direct all the simpler operations for preparing medicines. Without this knowledge, his education is deficient, in that he has not that know- ledge of his tools which is so essential to good work. He is in a condition to be imposed upon by imper- fect and worthless remedies, and must surely lose confidence in medicine, except given in large doses, for its gross effects. In country practice, a knowledge and practice of office pharmacy is an important element of success. The preparation of a remedy gives an interest in it that leads to thorough study and careful use. We learn what a good preparation is, and its advantages over the common stock in the drug trade, and we will afterward use more care in making our pur- chases. It economizes time, saves money, and cul- tivates habits of thrift, all of which are deficient in the medical profession. It is not only an excellent school for the physi- cian himself, but is also an admirable school for the student. It is a study of the Materia Medica, that gives a practical knowledge of remedies, and im- presses the mind through the organs of sense, leav- ing lasting impressions. I do not wish to be understood as advising the preparation of all medicines; or keeping the office 86 SPECIFIC MEDICATION. dirty and unsightly with the refuse of roots, barks, and herbs. This is the opposite of what we desire; skill is associated with neatness and cleanliness. I know some pharmacists that are so slovenly and dirty in person and surroundings, that I should not like to take their medicines. (The only one who ever offered an objection to office pharmacy, had these faults in excess.) A half dozen neat tin percolators of the capacity of two to ten pounds, hung in a closet or cupboard, with a large mortar, comprises the apparatus. The alcohol is kept in stock, and the crude material is procured at proper seasons and used fresh, or in some cases is ordered of the wholesale druggist when obtaining other medicines. The process of percolation is a very simple one. The crude material requires to be as finely commi- nuted and as closely packed in the percolator as possible. It is then covered with alcohol, and allowed to stand for forty-eight hours, when the tincture is drawn off. Filter it through paper, and you have a fine looking remedy, that will give sat- isfaction whenever used. In office pharmacy I have advised the strength to be viij. of the crude material to the pint of alcohol, because it is more easily manipulated by one who is not expert. All the formula in this work are of this strength, for every remedy named may be prepared in the office. The physician in the country will probably pre- pare only those remedies that are indigenous, and CLASSIFICATION OF REMEDIES. 87 at the proper season the year's supply. It is not very difficult to find some one to gather the crude material, and the preparation comes at that season when there is least to do. CLASSIFICATION OF REMEDIES. I have been in doubt in regard to the best plan of arranging the remedies in this study. Evidently the old classification will not serve our purpose, for it deals with indirect action; and the influence of remedies in poisonous doses. We have not ad- vanced far enough to make a new classification; at least, to make one that would facilitate our study. I have, therefore, concluded to take up the different articles in alphabetical order, and so far as possible make a brief review of our entire Materia Medica. When a remedy has no especial value, it will be named so; and when it seems to have a specific ac- tion, not fully determined, this will be pointed out for future experiment. Self-deception is a very un- profitable pursuit, and great care will therefore be employed to insure accuracy, and no statement made unless pretty thoroughly proven. The best preparations, and the best process for office manufacture will be given, also the form in which we deem it desirable to use them. When we have thus given the Materia Medica a review, we will be better able to make a classifica- tion. Some suggestions, however, as to the general in- 88 SPECIFIC MEDICATION. dications for treatment, and use of remedies, may not be out of place, and will serve as a further illus- tration of our idea of specific medication. In all acute, and most chronic diseases, our exam- ination of the patient and our therapeutics will take this order: 1. With reference to the condition of the stomach and intestinal canal-bringing them to as nearly a normal condition as possible, that reme- dies may be kindly received and appropriated, and that sufficient food may be taken and digested. 2. With reference to the circulation of the blood, and the temperature-obtaining a normal circulation as regards frequency and freedom, and a temperature as near 98° as possible. 3. With reference to the presence of a zymotic poison, or other cause of dis- ease—which may be neutralized, antagonized or re- moved. 4. With reference to the condition of the nervous system-giving good innervation. With reference to the processes of waste and excre- tion-that the worn-out or enfeebled material may be broken down and speedily removed from the body. 6. With reference to blood-making and repair-that proper material be furnished for the building of tissue, and that the processes of nutri- tion are normally conducted. 5 These are general outlines for the study of dis- ease, and the action of remedies in antagonizing it, and may aid in giving direction to our study, and enable each one to make a classification of remedies for himself. A brief consideration of each one, with examples of the application of remedies, CLASSIFICATION OF REMEDIES. 89 though it will be a repetition, may be of advantage to the student. • 1. The condition of the stomach is of first im- portance in the treatment of disease. It must be in such condition that it will receive remedies kindly, and permit their speedy absorption, in order that they give us the desired results. Surely, it is not difficult to see the necessity of this, if we take no further view than to obtain the curative ac- tion of remedies. If the stomach does not receive a remedy kindly, is irritated by it, we can not ex- pect ready absorption, or the complete curative action. If the stomach throws out its juices, which digest or decompose a remedy, we can not expect its curative action. If the stomach is secreting mucus in large quantity, if it is in that condition in which it is but a receptacle or retainer, then we can not expect the ready absorption of remedies, and will not get their curative action. We are accustomed to specify two conditions of the stomach, which may be tolerably easily deter- mined by constant symptoms, and which should always be corrected. These are:— Irritation of the stomach, marked by a reddened (bright) tongue, elongated and pointed, with some- times reddened and erect papillæ. It is accom- panied with unpleasant sensations of constriction, and tenderness on pressure over the epigastrium. There may be nausea, retching, or vomiting; and in the severer cases, when prolonged, an irritation 40 SPECIFIC MEDICATION. of the sympathetic, and finally of the spinal and cerebral nervous systems. Its treatment takes precedence of everything else, for until removed we can not expect the kindly or definite action of remedies. The remedies employed for its removal are: minute doses of Aconite; small doses of Ipecac or Lobelia; Hydrocyanic Acid, or better, a prepara- tion of the bark of the Peach tree; Rhubarb; Bismuth. These may be aided by the external use of the cold pack, hot fomentations, or rubefacient application, and sometimes an enema to remove the torpor of the lower bowel. From twelve to forty- eight hours, is usually the time required to effect it. But, the reader may ask, why if remedies are specific, name so many for the relief of so simple a pathological condition as gastric irritation? The question is pertinent, and we will endeavor to answer it. Each of these remedies has a direct ac- tion in this condition, and each may be relied upon as a remedy. We choose the remedy, however, with reference to the association of diseased action, and in some cases one will be found best, in others another. b. The atonic stomach, with increased secretion of mucus, and sometimes with considerable accu- mulations. It is marked by the broad tongue, heavily coated at its base, bad taste in the mouth, and feeling of weight and heaviness in the epigas- trium. The symptoms are distinct, and can not be mistaken. CLASSIFICATION OF REMEDIES. 41 When the condition is pronounced, in severer forms of disease, there is no means which will reach it so directly and speedily as an emetic. It needs to be prompt and thorough in action, not producing debility or leaving the organ irritable. If not re- quiring this, we may accomplish the same object by the use of the Alkaline Sulphites, followed by Nux Vomica. We have many minor lesions that can not be classified under these, to which we will find single remedies specific. Thus in simple nausea and vom- iting, without irritation, we prescribe Nux Vomica. In typhoid disease, with tumid mucous tissues, the Baptisia. Increased mucous secretion with irrita- bility, Oxide of Zinc. Imperfect gastric secretion, Hydrastis. Increased mucous secretion with im- paired functional activity, minute doses of Podo- phyllin, etc.* 2. We recognize the fact, that just in proportion to the variation of the circulation and temperature from the normal standard is the severity and activity of disease. The more frequent the pulse, and the higher the temperature, the more active a zymotic poison, the more rapid the progress of local or general disease, and the less able the body to protect itself, or expel the cause of disease. The rule here is absolute, and there is no variation from it. In therapeutics we find--that just in proportion as the circulation and temperature can be brought to, and *See Practice of Medicine, page 27. 4 42 SPECIFIC MEDICATION. maintained at the normal standard, just in that propor· tion are the processes of disease arrested, and vital pro- cesses re-established. These facts must surely have been noticed by ob- servers, and we can only wonder that they have never been clearly stated, and practiced upon. If we take as an example a case of fever, we will find that remedies that will reduce the pulse to a normal frequency, giving freedom to the circula- tion, will reduce the temperature, and that just in proportion as this is accomplished, the febrile symp toms disappear, and the various vital functions are re-established. If we maintain the circulation and temperature at this point, the fever must certainly cease. In acute inflammation, the rapidity of the local disease and destruction of tissue, is in the ratio of frequency of pulse and increase of temperature. Just in proportion as we get a normal circulation with reference to frequency and freedom, and diminished temperature, just in that proportion the inflammatory process is arrested. In asthenic inflammation we find another element in the pathology of the disease--a want of vital power, either in the whole or in the part. This must be antagonized by appropriate remedies. In others there is a zymotic or animal poison, which must be antagonized, destroyed, or removed. In chronic disease the law is just as absolute as in the acute. Given, any disease of function or structure, with a pulse maintained constantly shove CLASSIFICATION OF REMEDIES. 43 100 beats per minute, and a temperature above 100°, and the patient must die. The disease, as a general rule, will run its course rapidly to a fatal termina- tion just in proportion to the extent of this devia- tion. Recovery from chronic disease never takes place until the circulation and temperature approximate a normal standard. In any given case, the proba- bilities of cure are as the possibility of bringing and maintaining the circulation and temperature at the standard of health. The first evidences of amend- ment are announced by a diminution of frequency of pulse and a better circulation of blood, and by an equal temperature of the body, approximating 98°. These seem like dogmatic statements, and many will be inclined to dispute them, because op- posed or not named by the common authorities on medicine, but it only requires observation without prejudice to prove each position. We may claim then, that remedies influencing the circulation and temperature, toward the normal standard, are the most important of the Materia Medica. In very many cases the lesion of the circulation is a basic lesion, upon which others arise and are continued. When this is the case, the remedy that gives us normal circulation removes all the diseased processes which rest upon it. Thus we will find that arrest of secretion and excretion, lesions of in- nervation, of waste and nutrition, as well as the in- tensity of zymotic causes, are in proportion to the * 44 SPECIFIC MEDICATION. rapidity of the circulation. Conversely, as the pulse comes down to the normal standard, and the blood circulates freely, just in that proportion we have a restoration of the secretions and excretions, better innervation, better digestion and blood-mak- ing, and a more active waste and repair. Have we remedies that influence the circulation directly, giving a free and equal circulation, with diminution of frequency? Many of our readers will have asked this question before this, and an- swered it in the negative. Certain remedies will have been recommended to them as special sedatives, which they have used without the good results named and expected. How is this? It is a com- mon failing with physicians to expect a desired re- sult too soon, and endeavor to force it by large doses of medicine. This has been a common cause of failure in the use of Veratrum and Aconite. Others have purchased worthless medicines, which will readily account for the failure. Taking the article of Veratrum alone, and excepting Norwood's Tinc- ture, nine-tenths that has been sold was wholly worthless as a medicine. The theory with regard to the action of the class of special sedatives was erroneous. They were re- garded as depressants, and diminished frequency of pulse was supposed to depend upon their depressing influence upon the heart. It was the common error of large doses and poisonous action. All of these remedies are active poisons in large doses, and death occurs in all by cardiac syncope. In the cases CLASSIFICATION OF REMEDIES. of Veratrum, Digitalis, Lobelia and Gelseminum, slowness of pulse is a prominent symptom of the poisonous action. In the case of Aconite, extreme frequency of pulse is produced by the poisonous action. In medicinal doses (small), the influence of these remedies is that of a cardiac stimulant, and is un- doubtedly through the sympathetic system of nerves, which controls the entire circulation of the blood-not only the action of the heart, but of all the blood-vessels to the most minute capillary. I contend that this influence removes obstruction to the free circulation of the blood, as well as gives power to heart and muscular fibre of arteries. As obstruction to free circulation is removed, it requires less effort to move the blood; as the power of mov- ing the blood is increased there is less necessity of frequency of contraction upon the part of the heart. As a rule, the time required to effect sedation will bear a distinct relation to the time required for the development of disease, and its average dura- tion. Thus in an acute fever or inflammation from cold, the influence of the sedative may be promptly obtained, and the disease speedily arrested. In continued fever, the accession of the disease (in most cases), is slow in proportion to its duration and severity. Here there are grave lesions of function, possibly of structure, and we expect to obtain the influence of the sedative slowly.* *See Principles of Medicine, pp. 219, 264. The Eclectic Prac tice of Medicine, page 94. 46 SPECIFIC MEDICATION. Whilst each of the remedies named as arterial sedatives, Aconite, Veratrum, Digitalis, Gelsemi- num, Lobelia, exert a direct influence in this direc- tion, they are not equally valuable in all cases. The two first are pre-eminently the sedatives, their action being more definite and stronger, and adapted to a larger number of cases. The special adapta- tion of each to special forms of diseased action is named in the description of the remedy. The temperature bears such a constant relation to the frequency of pulse, and general condition of the circulation, that a remedy which will correct the one will also correct the other. Thus we find in practice that just as we bring the pulse to the normal standard by the use of an arterial sedative, in the same degree we reduce the temperature. This is the case in chronic as well as in acute dis- case. For instance, in a case of phthisis we find a temperature of 101° associated with a pulse above 100 beats per minute; if it is possible to bring the pulse down to 80 the temperature comes down to 98° and a fraction. If this can be maintained we find a cessation of tubercular deposit, and a repara- tive process set up in the lungs. We have some special means to influence the temperature, outside of the remedies acting upon the circulation. A full description of them would be out of place here, but may be found in my Prin- ciples of Medicine, p. 40. 3. The field of therapeutics embraced in our third proposition is very large, and will well repay careful CLASSIFICATION OF REMEDIES. 47 study. Whilst zymotic causes have been recog- nized in many of the severe acute diseases, but little has been done to determine their character, or the means to antidote them. Possibly the observations of Prof. Polli, with regard to the influence of the Alkaline Sulphites, was the first important step in this direction. The presence of such blood poison is readily de- tected, and we have advanced so far in our knowl- edge of remedies, that in many cases we can select the antidote with much certainty. I do not wish to be understood as claiming that we have any remedies that will immediately unite with all of a zymotic poison in the blood, destroy it, and at once restore health. Such an influence could not reason- ably be expected. But we have remedies which, introduced into the blood, will antagonize the zy- motic poison, as it comes in contact with it, arrest- ing its septic influence, or wholly destroying it. In some cases they act rapidly, in others slowly, but in all, if properly selected, with great certainty. The principal remedies of this class are the Alka- line Sulphites, (Sulphite of Soda being in most common use) and the mineral acids. The rules for the selection of the one or the other of these are quite simple, and very definite : In any given case presenting a pallid tongue, with white, or dirty-white, pasty coating, use the Alkaline Sulphites. In any given case presenting a deep-red tongue with brownish coatings, or deep-red glossy tongue, 48 SPECIFIC MEDICATION. and dark sordes, use mineral acids. In some cases we employ Sulphurous Acid, but in the majority, Muriatic Acid. Of our indigenous Materia Medica we have but one remedy that markedly possesses these proper- ties, and it possesses it in high degree. This rem- edy is the Baptisia Tinctoria, which may be used in either of the cases named, but is especially valued in the last. The reader will bear in mind that the activity of a zymotic poison is in exact proportion to the de- parture from normal function. With a rapid pulse, high temperature, and arrest of secretion, its devel- opment is rapid and its devitalizing influence marked. Or in the rare opposite case of congestive intermittent and cholera, as the circulation is en- feebled, and the temperature lowered, its progress is rapid. Hence, in order to antagonize a zymotic process, it is necessary, so far as possible, to obtain a normal circulation and temperature. This proposition can not be too strongly insisted upon. In a given case, the circulation and temperature being favorably in- fluenced by Aconite and Veratrum, Sulphite of Soda exerts an immediate and marked controlling influence over the fever poison. Whilst if it had been given without such preparation it would have had no influence at all, or but slight influence. Some causes of disease are destroyed and removed by remedies that increase waste and excretion. Pre- parations of Potash and Soda, especially the alka- CLASSIFICATION OF REMEDIES. 49 line diuretics act in this way. There are some organic remedies that exert a direct influence upon causes of disease, modifying or destroying them, as may be instanced in the action of Phytolacca in diphtheria. This action, however, in the majority of cases, is feeble. Causes of disease acting in and from the blood, are frequently removed by stimulating the excretory organs. Some are removed principally by the skin, others by the bowels, others by the kidneys. The cause of periodic disease, whatever it may be, plays a very important part in the diseases of some localities. Antagonize this cause, and the disease ceases, or at least is very much modified. Hence in the treatment of the diseases of the West, antiperiodics become the most important remedies. Quinia is a true specific, and may be taken as the type of these remedies. It fails frequently, possibly it is administered nine times where its specific action is obtained once. But it is not the fault of the remedy, but of the doctor. If the diagnosis is cor- rectly made, and the system is prepared for its ad- ministration, it will rarely fail, even when given in a single sufficient dose. I am satisfied that the study of the direct antag onism of remedies to causes of disease, must ad- vance the progress of rational medicine. It is pos- sible, and I deem it probable, that such research will give us remedies controlling all zymotic disease in its early stage. 4. The human body is a complex structure, united 5 50 SPECIFIC MEDICATION. in functional activity by a nervous system. As thir exerts a controlling influence, we should expect that its lesions would form a very important element of the study of pathology. This has not been the case, however, and we find pathologists and therapeutists giving it but very little attention. It is a wide field for study, and its cultivation will greatly advance medical science. A few suggestions may not be out of place here: Those functions which we have been accustomed to speak of as vegetative, are associated together, and to some extent governed by the ganglionic or sym- pathetic nervous system. It comprises digestion, blood-making, the circulation of the blood, nutri- tion, and secretion and excretion-these are the es- sentially vital functions, in the performance of which man has life. If they are properly performed, he has healthy life, if there is an aberration in either of them, one or more, he has diseased life. Is it possible to have disease, without a lesion of one of these? I think the reader will say it is not. If this be so, then this ganglionic system of nerves must play an important part in every disease.* Control and association of these vital processes being in the ganglionic system of nerves, we would naturally expect it to furnish the readiest means of reaching them and correcting their lesions. If there are remedies then that influence the gangli- ɔnic nerves directly, and through them the vital *See Principles of Medicine, page 306. CLASSIFICATION OF REMEDIES. 51. processes of the body, they must become our most direct and important therapeutic means. It is in this way that a large number of specific remedies act, as I believe. The sedatives, Aconite, Veratrum, Gelseminum, Lobelia, and others, as Cactus, Bella- donna, Eryngium, Phytolacca, Hamamelis, Pulsa- tilla, etc., very certainly produce their effects through it. The association of the spinal-cord with the sym. pathetic brings vital functions in relation with our conscious life, and through its superior expansion the brain, adds suffering from disease. Conversely, mal-conditions of conscious life are reflected through this association and influence vital processes. Whilst, therefore, it is very important to reach lesions of vegetative life directly through the gan- glionic system of nerves, it is no less important to control any disease producing influence that might be extended from the cerebro-spinal centres. 5. Lesions of waste and excretion are elements of every disease. In some they form a principal part, in others in less degree, but in all they require to be estimated in diagnosis and therapeutics. They range themselves under the common classification of excess, defect, and perversion, and usually it is not difficult to determine their character, and select means that exert a direct influence. Constant waste is a necessity of life, as is constant removal of this waste. If the materials of the body are not broken down and removed as they have served their purpose, the body is old, imperfect, and SPECIFIC MEDICATION. has lost functional power to this extent. If the material is broken down and removed to the blood, but not carried out by the excretions, we will have an impairment of life from its presence in the blood. I have given this subject full consideration in my Principles of Medicine, pp. 116 to 185, to which the reader is referred. Too rapid waste of tissue is sometimes an impor- tant element of disease, requiring care in diagnosis and the application of remedies. A perversion in waste and excretion is a common element of disease. In the breaking down of a protean body, it passes through many phases, and in its metamorphosis, it assumes forms that are noxious to life, if they have any degree of perma- nency, or are in any considerable quantity. Lesions in retrograde metamorphosis are therefore to be esti- mated, and remedies which influence it become im- portant. We have already noticed that many causes of disease act in and from the blood. They are zy- motic poisons, or animal matter undergoing change, and influence the blood and life in different degree, in proportion to their quantity, and especially in proportion to their activity in setting up the septic process. These may be antagonized or destroyed in many cases; in others the natural process of re- trograde metamorphosis is stimulated, and they are transformed into urea and other innocuous bodies fitted for excretion by kidneys, skin and bowels. Means that increase the activity of these excretions CLASSIFICATION OF REMEDIES. 58 are frequently sufficient for the removal of such causes of disease. 6. The necessity of regarding the nutritive pro- cesses during the progress of disease, is now admit- ted by all advanced physicians, and insisted upon by such writers as Chambers, Anstie, Bennett and others. Experience has conclusively proven that proper food with good condition of the digestive apparatus, without medicine, give a success in the treatment of the graver acute diseases, that was never obtained by any other method of treatment. As we have already seen, the condition of the stomach and digestive apparatus is of first impor- tance in all forms of disease, and its lesions demand first attention in our therapeutics. We have shown that this was essential to the successful administra- tion of remedies, it is no less necessary that the patient may take and appropriate proper food. The administration of remedies that increase functional activity of the digestive apparatus, or aid in the digestive process, are sometimes important means. The selection of appropriate food, and the use of restoratives is supplemental to this. The object is to place the digestive organs in good con- dition to receive and prepare food for admission tc the blood; to furnish such material to the blood as may be necessary for its perfect organization, and for the renewal of tissue. REMEDIES. ABIES CANADENSIS. (HEMLOCK.) This agent has been employed in medicine for a long time; the bark in decoction as an astringent, the foliage in hot infusion as a diuretic and diaphoretic, and the oil as a stim- ulant local application. It undoubtedly possesses valuable properties. The following properties and uses are suggested to those who live where it may readily be obtained: 1st. A tincture of the recent inner bark in diluted alcohol; use in general asthenia, with pallid mucous membranes and feeble digestion; also, in diseases of the respiratory mucous membranes. 2d. A tincture of the foliage in dilute alcohol; use in irri- tation of the urinary organs, and in disease of the skin. 3d. A sack of wheat bran flattened, and sprinkled with oil of hemlock, is an excellent application to the loins in chronic disease of the kidneys and reproductive apparatus. It may be worn for weeks. ACHILLEA MILLEFOLIUM. (YARROW.) Preparation -Prepare a tincture of the recent herb, 3viij. to alcohol 50° Oj. Dose, gtt. v. to 3ss. This agent, though feeble in its action, is much better than many in common use. It acts directly on the urinary appa- ratus, and the reproductive organs of the female. I have used it to allay irritation of the kidneys, and vesical and urethral irritation. In these cases its influence is somewhat similar to that of Buchu and Uva Ursi. It is employed with advantage in atonic amenorrhoea, menorrhagia, and vaginal leucorrhoea. ACONITUM NAPELLUS. 55 ACIDS. There is a specific use for acids in the treatment of disease, which we wish to study carefully. In any form of disease we may have an excess of the alkaline salts of the blood. This may be the basis of diseased action, or but a complica- tion rendering it more intense, but whether the one or the other, it needs to be recognized and have direct treatment. The indications of excessive alkalinity are very plain, and need not be mistaken by the youngest practitioner. The color of the mucous membranes is deep red, especially of mouth and tongue; the coating of tongue, sordes, or any ex- udative material, has a dark color, usually brownish. It makes no difference what the diseased action is, in its total- ity, or what it is called, the deep red, somewhat dusky color, always demands the administration of acids. There is but one exception to this, and that is a rare one, in which the excess is of soda, but with a defect of potash. In this case the administration of a salt of potash will an- swer a better purpose than the acid, or may be combined with it. Muriatic acid is preferable in most acute cases, and should be used so diluted, and in such quantity, as to be pleasant to the patient, and until the indication for its use is removed. Lactic acid is sometimes preferable with child- ren, and in some cases of chronic disease, especially when associated with indigestion. The vegetable acids may be used in acute disease, but are not so good as those named. ACONITUM NAPELLUS. (ACONITE.) Preparation.-A tincture of the root (imported from Ger- many) is the stronger and more uniform preparation. It should be prepared by percolation; the strength being ounce. for ounce; though, if constantly made in the office, it will be easier to make it 3viij, to the pint, the dose being propor- tionately increased. 56 SPECIFIC MEDICINES. The medium dose one-third of a drop, and the form of administration: R Tincture of Aconite root, gtt. v. to x.; water, 3iv.; a teaspoonful every hour in acute disease, every two or three hours in chronic disease. To a child two years old the proportion is gtt. ii. to v. to water iv. Aconite is a stimulant to the sympathetic system of nerves, and increases the power of the heart to move the blood, at the same time that it places the blood-vessels in better con- dition for its passage. It will be recollected that the same system of nerves governs the movements of the heart and of the entire system of blood-vessels. What influences one will, therefore, influence the other in the same manner. But Aconite is said to be a sedative; and by a sedative we are to understand a remedy that diminishes the frequency of the pulse. How can Aconite, therefore, be a stimulant and a sedative? There is no doubt but that Aconite is one of the most cer- tain remedies we have to reduce the frequency of the pulse in certain conditions of disease. And the condition is that in which there is a want of power on the part of the heart, and a like want of innervation to the capillary system of blood-vessels. Aconite in small doses lessens the frequency of the pulse, because it removes obstruction to the flow of blood in the vessels, and gives greater cardiac power. We employ it in all forms of fever, to control the circula- tion, and diminish the temperature. Used in the doses named, it gives greater freedom to the circulation, at the same time that it diminishes the frequency of the pulse. It seems to remove obstruction to the free circulation of the blood, at the same time that it removes irritation of the cardiac nerves,. and gives increased power to the heart. Its action in inflammation is as pronounced as in fever. It directly antagonizes inflammatory action, and in the early stage will arrest it speedily-if this is the sedative in- dicated. There are some diseases of an inflammatory character to which Aconite is specific, that deserve mention. The first of ACONITUM NAPELLUS. 57 these is tonsillitis, in which we employ it by internal ad- ministration, or better by the use of the steam atomizing ap- paratus. In some forms of mucous croup, with enfeebled circulation, in muco-enteritis, and in simple colitis or dysen- tery from cold, I never think of making any other prescription. As the notice of the action of Aconite in croup may not impress the reader sufficiently, I desire to say that I regard it as the most certain internal remedy in all forms of this dis- ease, and if one cannot find a specific indication for another remedy, let him give this. I prefer g t. ij. to water živ., a teaspoonful every fifteen to thirty minutes. Stillingia lini- ment is the external application. To point out the special indications for the use of Aconite I can not do better than reproduce the editorial in Septem- ber Journal of 1868 on the "Differential Therapeutics of Ve- ratrum and Aconite:" To determine which of a class of remedies is applicable in a given case, is the most difficult task of the physician, and any information in this respect is of much value. I doubt whether any one using the two remedies named, would be willing to risk giving this estimate. Many may have an em- pirical intuition in regard to it, but most could venture noth- ing but a guess. Veratrum is the remedy where there is a frequent but free circulation. It is also the remedy where there is an active capillary circulation, both in fever and inflammation. A full and bounding pulse, a full and hard pulse, and a corded or wiry pulse, if associated with inflammation of serous tissues, call for this remedy. Aconite is the remedy when there is difficulty in the capil- lary circulation, a dilatation and want of tonicity of these vessels, both in fever and inflammation. In general terms, Veratrum is the remedy in sthenia, Aco- nite in asthenia; but there are too many exceptions to this to make it a safe rule for our guidance. It is the remedy for the frequent, small pulse, the hard and wiry pulse (except in the cases above named), the fre- 58 SPECIFIC MEDICINES. quent, open and easily compressed pulse, the rebounding pulse, the irregular pulse, and indeed wherever there is the evidence of marked enfeeblement of the circulation. It is the sedative I associate with Belladonna in congestion, especially of the nerve centers, and to relieve coma. Whilst I would use Veratrum with Gelseminum in determination of blood to the brain, and in active delirium. Veratrum acts more efficiently upon the excretory organs; indeed I believe it to be one of the most certain remedies we have to increase excretion. Hence it is employed with great advantage for those purposes usually called alterative. Aconite controls excessive activity of the excretory organs, whether of the bowels, kidneys, or skin. Thus it is our most certain remedy in the summer complaint of children, associ- ated with Belladonna in diabetes insipidus, with the bitter tonics and Strychnia in phosphuria and oxaluria, and with the mineral acids in night sweats. ACTEA ALBA. (WHITE COHOSH.) Preparation.-Two preparations may be used: first, a tinc- ture of the recent root, 3 viij. to alcohol 98 per cent. Oj.; sec- ond, a tincture of the dried root in the same proportion, but using alcohol 76 per cent. Let the dose range from gtt. j. to xx. The white cohosh has had but a limited use in medicine, yet it possesses such properties that it will undoubtedly prove useful when studied. The direction of experiment will be to determine its influence on the functions of waste and nu- trition, and its special action on the reproductive organs of the female. BLOOMINGTON, ILL., Sept. 30. DR. SCUDDER: I intended to have written to you in regard to one specific property of the Actæa Alba. As you have reached it in your order, you can do as you wish in regard to inserting this. It is specific in controlling after-pains. There is probably no remedy known that equals it. Make a tea of it, and drink freely. This power in controlling after-pains suggests that it will prove valuable in congestion and neu- ralgia of the womb. W. FULTON, M, D. · : ESCULUS GLABRA. ACTEA SPICATA, (BANEBERRY.) 59 Prepare a tincture from the root gathered in the fall, using strong alcohol. In large doses it is a violent purgative, and may produce inflammation of the bowels. It causes tormina and tenes- mus, and seems to extend its influence to all the abdominal viscera, the urinary apparatus included. Its action is at- tended with unpleasant sensations in the head, and some times it produces severe headache. In small doses (gtt. ij. to water 3iv.) it may be used in diar rhoea and dysentery, some forms of colic, and in disease of the urinary apparatus when the passage of urine is attended with tenesmus. ADANSONIA DIGITATA. (BAOBAB.) The bark of this tree was employed with great success by Dr. Duchassaing, of Guadaloupe, in intermittent fevers. It is also a very good diaphoretic. One ounce of the bark was boiled in a pint and a half of water to one pint, and the whole taken in the course of a day. A tincture may be prepared in the usual way from the bark, and used in doses of from one to thirty drops, as a sed- ative, diaphoretic and antiperiodic, in the treatment of ma- larial and other fevers. ÆSCULUS GLABRA. (BUCKEYE.) Preparation.-Whilst the bark possesses medicinal proper- ties in considerable degree, and may be used, a tincture of the nuts will probably be the best preparation. Take of the recent nuts, fully ripened, four ounces; bruise them thoroughly, and cover with alcohol 76 one pint; let it stand for two weeks; strain and filter. Of this tincture add from one to two drachms to four ounces of water-the dose being one teaspoonful. 60 SPECIFIC MEDICINES. The buckeye has been used to but a limited extent in med- icine, yet its activity is such (as a poison), that it will proba- bly prove very valuable when thoroughly studied. In my boyhood, I well remember persons carrying "buckeyes" in their pockets as a sovereign cure for "piles," and at a later period as a remedy for rheumatism. Doubtless this sugges- ted the first use of the Esculus in medicine. It has been used in the treatment of hemorrhoids with much success, and I am satisfied that in some forms of the disease it is the most certain remedy we possess. I have also given it in a few cases of diseased uterus with good results cases in which the entire organ was enlarged, the cervix tumid, with too frequent recurrence of the menstrual flow. The marked influence of the Esculus on the nervous sys- tem would suggest a line of experiment likely to lead to the development of valuable properties. It has already been em- ployed as a stimulant to the nervous system in some cases of paralysis. We may reason in this way: a remedy that cures hemor- rhoids must exert a powerful influence upon the circulation; whilst its poisonous action, often witnessed-vertigo, dimin- ished sight, wry neck, fixed eyes, paralysis, convulsions, etc., show its influence upon the nervous system. ÆSCULUS HIPPOCASTANUM. (HORSE CHESTNUT.) Preparation.—Take of the recent nut, fully ripe, four ounces, bruise it thoroughly, and cover with alcohol 76° one pint: let it stand fourteen days and filter. Dose, two to four drops, in water. The bark of this variety has been employed to a limited extent as a tonic, and possesses feeble antiperiodic powers. Quinine being employed to break the chill, this agent was sufficient to prevent its recurrence. The pulverized kernel has been used as a sternutatory for the relief of headache and facial neuralgia. The nuts were also thought to possess some special influence over hemorrhoids and rheumatism. AGARIC. 61 The influence upon the nervous system is similar in kind to the buckeye, though not so active. This probably will be its best field of action, standing midway between Belladonna on the one hand and Nux Vomica on the other. It exerts the same influence upon the circulation as the Æsculus Glabra, and has been successfully employed in the treatment of hemorrhoids. It will doubtless be found to improve the circulation generally, and may be employed whenever there is want of power in the heart, capillary stasis, or tendency to congestion. ETHUSA CYNAPIUM. (FOOL'S PARSLEY.) A tincture is prepared from the flowering plant, using strong alcohol. This remedy has had but a limited use, and must be em- ployed with care. It may be recommended in active delir- ium, when patients become excited from slight causes, and are liable to transports of rage. There is also confusion of intellect, dizziness, as if intoxicated. Violent headache with dizziness. To water iv. add gtt. ij. of the tincture, and give a tea- spoonful every two or three hours. AGARIC.* History. This is obtained from various fungus plants of the mushroom tribe. They absorb a great amount of oxygen with evolution of hydrogen and carbonic acid gas, and con- tain considerable proportions of nitrogen. They are destruc- tive to nearly all organic matter upon which they grow. Ac- cording to Dr. M. A. Curtis, of N. C., the genus boletus, as now constituted, includes only fleshy species, with a hymeni- um composed of sporable tubes. Those species formerly in- cluded in Boletus, and whose hymenium is composed of pores, now form the genus Polyporus. *The following is taken from the new edition of King's American Dis pensatory. 62 SPECIFIC MEDICINES. The Polyporus Officinalis (Boletus Laricis), known by the name of White Agaric, Purging Agaric, etc., is procured from Asia, Corinthia, Russia, Central America, and the Rocky Mountains, where it is found growing upon the Larch. It is in masses, varying from the size of an ordinary apple to that of a large nutmeg-melon; its shape somewhat resembles a horse's hoof; it is reddish-gray or yellow externally, whitish internally, and of a spongy, friable consistence; hymenium concrete; substance of the pileus consisting of subrotund pores, with their simple dissepiments; pileus corky-fleshy, ungulate, zoned, smooth; pores yellowish; it has a feeble odor, and a bitter, acid, somewhat sweetish taste. Braconnot found in it 72 parts resinous matter, 2 bitter extractive, 26 of a nutri- tious animalized principle, which he termed fungin. Ben- zoic acid and several salts have likewise been found in it. It is collected in August and September, deprived of its outer covering, and then dried and placed in the sun. Polyporus (Boletus) Ignarius, Agaric of the. Oak, is a fungus found on the oak, cherry, willow, plum, and other trees; when young it is soft, but gradually becomes hard and woody. In shape it somewhat resembles the preceding; its upper smooth surface is marked with dark circular ridges, and its under is very porous, and of a yellowish-white color It is tasteless and inodorous. The Polyporus (Boletus) Fomentarius, growing on similar trees with the P. Ignarius, when cut in slices, beaten, soaked in a solution of nitre, and dried, forms an in- flammable substance, known as Spunk, Amadou, or German Tinder. The Polyporus Pinicola grows upon the pine, birch, tamarac, fir, and similar trees; with absolute alcohol the fresh fungus forms a dark-red, intensely bitter tincture. A white amorphous powder, called laricin, is obtained from some of these plants. It has a bitter taste, is soluble in alcohol and oil of turpentine, forms a paste with boiling water, and has the formula C14H12O4. Properties and Uses.-The dust of the Larch Agaric is irri- tating to mucous surfaces, causing tears when it enters the eyes, and sneezing, cough, and nausea, when the nostrils are exposed to it. It has been used in half-drachm or drachm AGARICUS MUSCARIUS. 63 doses as a purgative; in larger doses as an emetic. In doses of from three to ten grains, gradually increasing to sixty grains, in the course of the twenty-four hours, it has been found efficacious in arresting the nocturnal perspiration of consumptives. Externally, it has been used, together with the Agaric of the Oak, as a styptic, and said to restrain not only venous but arterial hemorrhages, without the use of ligatures. It does not appear, however, to possess any real styptic power, or to act otherwise than dry lint, sponge, or other soft applications. Prepared with nitre, as for tinder, it has been used as a species of moxa. The P. Officinalis and the P. Pinicola, in doses of from three to four grains of the powder, repeated every three or four hours, or of the concentrated tincture in doses of five drops, have both been found valuable in the cure of obsti- nate and long standing intermittents, and other diseases com- mon to malarial districts; as obstinate bilious remittent fever, chronic diarrhoea, chronic dysentery, periodical neuralgia, nervous headache, ague cake, and increased flow of urine. They have likewise proved useful in long standing jaundice, and in the chills and fever common among consumptive patients. The tincture of Boletus exerts a marked influence upon the spinal and sympathetic nervous system, in certain cases of disease. It has been successfully employed in the treat- ment of epilepsy and chorea, and to check the rapid pulse with hectic fever and night sweats in phthisis. It has also been recommended in insanity where there is a feeble cere- bral circulation and imperfect nutrition. And, also, in neu- ralgia, with similar symptoms. AGARICUS MUSCARIUS. (FLY AGARIC.) Make a tincture of the fresh fungus, using strong alcohol. Probably the best defined indication for this remedy is in- voluntary twitching of the muscles of the face, forehead, and even of the eyes, so that objects are not seen well because 1 64 SPECIFIC MEDICINES. they seem to move; drawing of the tissues of the forehead and nose. Pressing pain in the occiput and an inclination to fall backwards is also a very good indication. The dose must be small, gtt. i. to water 3iv., or one of the homoeopathic dilutions. AGAVE AMERICANA. (CENTURY PLANT.) The only report we have of this agent is from Dr. Penn, U. S. A., in the treatment of scurvy: "Every case has improved rapidly; the countenance, so universally dejected and de- spairing in the patient affected with scurvy, is brightened up by contentment and hope in two days from the time of its in- troduction. The most marked evidences of improvement were observable at every successive visit. From observing the effects of the Maguey in the cases which have occurred in this command, I am compelled to place it far above that remedy which, till now, has stood above every other-lime juice. The manner in which I use it is as follows: The leaves are cut off close to the root. They are placed in hot ashes until thoroughly cooked, when they are removed, and the juice ex- pressed. The expressed juice is then strained, and given in doses of 3ij. to Ziij. daily.” I should be glad if some of our southern readers would try a tincture of the recent leaves, made by cutting them in small pieces and covering with alcohol. We want to determine its influence on the circulation and on the nervous system. The dose would be about ten drops. AGRIMONIA EUPATORIA. Preparation.-Prepare a tincture from the fresh herb 3 viij. to Alcohol 98 Oj. Dose from gtt. j. to 3ss. Agrimonia exerts a slight stimulant influence upon all the vegetative processes, and under its use we find an improve- ment of appetite, digestion and nutrition, It exerts a specific influence upon mucous membranes, checking profuse secretion, and giving tone. Thus it has been ALKALIES. 65 employed with advantage in cases of chronic bronchitis, phthisis with increased secretion, and humoral asthma. But it is especially useful in chronic catarrhal disease of the kidneys and bladder, and will frequently prove curative. It gives tone and strength to these organs, and may well re- place the more common tonic diuretics in many cases. The strongest indication for agrimonia is pain, simulating colic, pointing in the lumbar regions, or uterine pain asso- ciated with lumbar uneasiness. Sometimes the pain will seem to involve the lower portion of the liver. AILANTHUS GLANDULOSA. (TREE OF HEAVEN.) A tincture may be prepared from the fresh inner bark, using strong alcohol. The best indication for this remedy is epileptiform con- traction of muscles. It has been recommended for the cure of epilepsy, but its reputation has not increased with use. Dose from the fraction of a drop, or a dilution, to ten drops. ALISMA PLANTAGO. (WATER PLANTAIN.) Prepare a tincture from the fresh root, using alcohol of 98. Dose, add gtt. v. to x. to water 3iv., a teaspoonful every two to four hours. It is indicated by irritation and uneasiness in passing water, frequent desire to micturate, pains in the loins, and involun- tary muscular movement. It has been used in chorea and epilepsy with reported success. ALKALIES. It is well to consider the specific use of alkalies in this re- lation; as they are the opposite of acids. We may say of these, as of acids, that their deficiency is found as a constit- uent element in all forms of disease-in some cases being the basis of a morbid action, in others but a complication; but, whenever found, an important element and demanding direct treatment. 66 SPECIFIC MEDICINES. The symptoms of deficiency of these salts of the blood are very plain, and, using the language of the Prophet, "He who runs may read." The tongue is broad and pallid, its coating pasty and white, or yellowish white. The mucous membranes are uniformly pallid. As these evidences are absolute and readily determined, it is not necessary to name others not so constant. Whenever we find this deficiency of the alkaline salts we will observe, as the result: loss of power in the stomach, en- feebled digestion and slow absorption, impairment of the cir- culation, arrest of nutrition and waste, and enfeebled inner- vation. These will correspond in degree to the deficiency. So marked are these results, that I have long regarded the diagnosis, with regard to excess or deficiency of the alkaline salts, as of the highest importance. Indeed in some forms of disease, especially of a typhoid character, it is the princi- pal element upon which a successful treatment is based. Soda is the natural salt of the blood, and exists in the body in the largest proportion. Whenever, therefore, we have the evidence of deficiency of the alkaline salts, and no spe- cial symptoms indicating others, we will give a salt of soda. In many cases I order bicarbonate of soda in water, in such quantity that it will make a pleasant drink, and let the pa- tient have it freely. If, at the same time, we wish an antiseptic influence, we may give the sulphite or hyposulphite of soda or the chloride of sodium. I am satisfied that I have seen patients die from depriva- tion of common salt during a protracted illness. It is a com- mon impression that the food for the sick should not be sea- soned, and whatever slop may be given, it is almost innocent of this essential of life. In the milk diet that I recommend in sickness, common salt is used freely, the milk being boiled and given hot. And if the patient cannot take the usual quantity in his food, I have it given in his drink. This mat- ter is so important that it can not be repeated too often, or dwelt upon too long. ALNUS RUBRA. 67 The most marked example of this want of common salt I have ever noticed has been in surgical disease, especially in open wounds. Without a supply of salt the tongue would become broad, pallid, puffy, with a tenacious pasty coat, the effusion at the point of injury serous, with an unpleasant watery pus, which at last became a mere sanies or ichor. A few days of a free allowance of salt would change all this, and the patient would get along well. A salt of potash is indicated where there is feebleness of the muscles to a greater extent than can be accounted for by the disease. Occasionally such want is expressed in a marked manner by feebleness of the heart. Ammonia will, occasionally, prove the best salt for tempo- rary use, especially where there is great debility. But when so used, it should be followed by the free use of common salt, or some salt of soda. ALETRIS FARINOSA. The Aletris is a gastric stimulant and improves digestion. It has also proven a valuable tonic in uterine diseases. It deserves thorough examination, which I hope some of our readers will give it and report. Prepare a tincture from 3viij. of the root to Alcohol 76, Oj. The dose would be from two to ten drops. ALNUS RUBRA. (TAG ALDER.) Preparation.-Prepare a tincture from the recent bark, 3viij. to alcohol 98, Oj. Dose gtt. j. to xx. We may employ the Alnus in infusion, or in the form of tincture with dilute alcohol; the first being preferable if we wish its greatest influence. It exerts a specific influence upon the processes of waste and nutrition, increasing the one and stimulating the other. It is thus a fair example of the ideal alterative, and is one of the most valuable of our indigenous remedies. 68 SPECIFIC MEDICINES. Its special use seems to be in those cases in which there is superficial disease of the skin or mucous membranes, taking the form of eczema or pustular eruption. In these cases I have employed it as a general remedy, and as a local applica- tion with the best results. It does not seem to make much difference whether it is a phlyctenular conjunctivitis, an ul- cerated sore mouth or throat, chronic eczema or secondary syphilis presenting these characteristics, it is equally bene- ficial. ALOES. The use of Aloes in medicine should be quite limited, but still it has a place. I believe that in small quantity and in combination with other agents that act upon the upper in- testinal canal, it proves a good cathartic, as in the following: R Podophyllin, grs. x.; leptandrin, grs. xxx.; aloes, grs. xx.; extract of hyoscyamus, 3ss. Make thirty pills. One of them at night will prove an excellent laxative, and those who em- ploy cathartics freely will like the formula. But it is not for this purpose that I would recommend Aloes, but for one that may seem very singular. In small doses it exerts a direct influence upon the waste and nutri- tion of the nervous system. In cases of feeble innervation, especially in persons of gross habit, it will be one of our best agents. I have usually prescribed it with tincture of nux vomica or with tincture of belladonna. The dose of a strong tincture being from two to ten drops. In some cases it will prove serviceable when associated with the bitter tonics, as in this: R Extract of nux vomica, grs. vj. ; aloes, grs. xv.; hydrastine, 3ss. Make thirty pills. One may be given three or four times a day. ALSTONIA CONSTRICTA. (THE FEVER BARK OF AUSTRALIA.) The Alstonia Constricta is a native of Australia, being found in the interior of that vast country. It has been used for several years by the herdsmen and inhabitants of the in- ALSTONIA SCHOLARIS. 69 terior as a substitute for quinine. Brought to this country in 1876, it was exhibited at the Centennial with the Austra- lian exhibit, but attracted very little attention. A friend of mine procured a piece of the bark, and gave it a pretty thor- ough test, with such marked results in the cure of ague, that he resolved to import it and sell it as an "ague cure. In this way it came into my hands, and during 1879, it has been quite largely distributed and tested. Whilst it may not be as certain in its action as quinine, especially in recent agues, it seems to produce more permanent results. So that an ague cured with Alstonia is likely to remain cured, and is not simply "broken." It seems to be especially indicated in cases of depraved secretions, the skin being sallow and dirty, the bowels irregular, the tongue inclined to be dirty, and the urine depositing a sediment. Agues not curable with qui- nine, and cases of chronic ague, will give a very good field for its use. Those who have used it most claim that it will be found a most excellent tonic and restorative, especially where the se- cretions are defective as above. As an antiperiodic the dose will be somewhat less than qui- nine, say ten grains in divided doses: as a tonic it may be given in grain doses. ALSTONIA SCHOLARIS. (DITA BARK.) The Alstonia Scholaris is a native of the Phillipine Islands, and its bark has been an article of commerce for some years. Prepare a tincture from the bark, the usual way, using 98 per cent. alcohol. Dose, from the fraction of a drop to gtt. x. The Alstonia Scholaris is likely to prove an excellent rem- edy in disease of the bowels, with imperfect digestion and diarrhoea, especially in malarial regions. It has been claimed to have antiperiodic properties, but these are feeble, as com- pared with the Alstonia Constricta. 70 SPECIFIC MEDICINES. AMMONIUM, BROMIDE OF. The Bromide of Ammonium is a stimulant to the nerve centers; increasing waste and improving nutrition. I have employed it principally in epilepsy, in some cases of which it is undoubtedly a specific. I do not think I can point out the exact cases in which it is likely to prove curative, as the evidences of pathological states in this disease are very obscure. Its use, therefore, will have to be empirical. I have used it now for some twenty years, and it has given excellent satisfaction. But whilst it has effected permanent cures in a large number of cases, it has only proven of tem- porary benefit in some, and has wholly failed in others. We not unfrequently meet with disease, in which there is disordered innervation, manifesting itself as epileptiform, partially spasmodic, or in other ways, but in which there is undoubtedly the same enfeeblement of the cerebro-spinal centers. In these cases Bromide of Ammonium is the remedy. In diseases of children, I have been accustomed to employ this remedy in convulsions, following the first influence ob- tained by Lobelia or Gelseminum, and with marked success. When a child is subject to repeated attacks of convulsion, from slight causes, the Bromide of Ammonium may be used to remove the predisposition. In some cases of whooping cough it exerts a direct action, as it does in many cases of nervous cough in both child and adult. I have used it in this proportion: R Bromide of Ammo- nium, 3ss; water, 3iv. A teaspoonful four times a day. AMMONIUM, IODIDE OF. Iodide of Ammonium increases retrograde metamorpho- sis at the same time that it exerts a stimulant influence upon the nervous system, especially the sympathetic system. Thus it can be employed with less risk than Iodide of Potassium, when the nutritive powers are feeble, as is the case occasion- ally in secondary syphilis. 1 1 AMYGDALIS PERSICA. 71 It has been employed in certain cases of persistent head- ache with excellent results. They are those in which the eye is dull, the face expressionless, the circulation feeble, the patient being of a full habit. The dose will be: R Iodide of Ammonium, 3ij.; water, 3iv. A teaspoonful every four hours. AMMONIUM MURIATICUM. We employ the Muriate of Ammonia as a stimulant to the capillary circulation. The best indication for it is a dusky flush of the skin, the redness effaced by pressure returning slowly. A dusky redness of mucous membranes, not indica- tive of blood poisoning, will sometimes call for this remedy. It is also a good remedy when there is oppressed respiration, with bronchial sounds on auscultation, neither dry or moist. We also employ a bath of Muriate of Ammonia as a stimu- lant to the skin, especially in the eruptive fevers when the eruption is tardy in appearing. In some cases it is used with an inunction, being rubbed up with lard. AMPELOPSIS. The Ampelopsis comes under the general classification of alteratives. It is a feeble agent in this direction and will have but a limited use. It would be well to have it thoroughly tested, and for this purpose I would suggest a tincture of the fresh bark, in doses of from one-fourth to one teaspoonful. AMYGDALUS PERSICA. (PEACH TREE.) Preparation. Thus far we have employed infusion of the bark of the young limbs of the Peach Tree; and, to a limi- ted extent, a tincture of the recent bark with dilute alco- hol. The first will be found preferable in cases of acute gastric irritation; but for ordinary office use, I would suggest the following: Take of the green bark of the young limbs (suckers), a sufficient quantity, and cover with alcohol 50 per cent., one 72 SPECIFIC MEDICINES. pint to each eight ounces: let it stand for fourteen days, and express—a press of some kind will be an aid. The dose will be from five to thirty drops. The infusion or tincture, as above prepared, has a direct influence in quieting irritation of the stomach and upper in- testinal canal. It is also a mild tonic, improving the func- tions of digestion. For these purposes it is one of the most valuable articles in the materia medica. It also exerts an influence upon the circulation, and upon the nervous system, which deserves investigation. AMYL NITRITE. An ethereal liquid of a yellowish color and peculiar not un- pleasant odor, insoluble in water, but soluble in rectified spirits with which it should be dispensed. The dose will be from the fraction of a drop to two drops, or in homoeopathic dilution; in large doses, or inhaled, it is a powerful poison. It is indicated by flushing of the surface and burning pain, a burning pain with natural color of the skin; depression, difficult breathing, sharp pain in precordial region extending to shoulder and arm. It has been employed in angina pec- toris, asthma, epilepsy, nervous headache, chorea, hiccough, gastralgia, and some other forms of nervous disease. Dr. W E. Saunders, of Indore, calls attention to the value of nitrite of amyl in ague, and records a number of cases in which advantage has been derived from its use. The drug itself, he remarks, is inexpensive, and goes a long way. He now uses amyl nitrite mixed with an equal part of oil of coriander to render it less volatile, and at the same time to cover its odor. He regards it as the most powerful dia- phoretic he has seen, and he uses it in all cases of fever to produce diaphoresis. Dr. Saunders observes that he does not mean to say that quinine should not be used in these cases, for there is ample proof that it tends to check the return of the attacks, and removes to some extent the septic condition of the blood, in- duced by the malarial poison, and this more especially if ANEMONE NEMOROSA. 73 small doses of opium are combined with it. In no case did the amyl fail to remove the attack in about one-third the usual time, and in most cases the fever did not return. His method of administration is this: Four drops of the above mixture, or two of amyl, are poured on a small piece of lint, which is given into the hands of the patient, and he is told to inhale it freely. He soon becomes flushed, and both his pulse and respiration are much accelerated. When he feels warm all over, the inhalation is discontined, as the symptoms continue to increase for some time afterwards. A profuse perspiration now sets in, which speedily ends the attack. In some cases, however, the cold stage passes off without any hot or sweating stage. ANAGALLIS ARVENSIS. (RED CHICKWEED.) This agent possesses active properties, but has not been studied. It has been extolled in hydrophobia, delirium, ma- nia, epilepsy, etc., which will suggest the line of experiment. The best preparation, probably, will be a tincture of the recent chickweed in dilute alcohol (50), 3 viij. to the pint; dose quite small-coming within one or two drops. ANEMONE NEMOROSA. (WOOD ANEMONE-WIND FLOWER.) This is also an active agent, and will probably repay care- ful study. It influences the functions of waste and repair, but acts directly upon the nervous system. Belonging to the same family as the Pulsatilla, its action will be somewhat analogous. The preparation best adapted for study will be a tincture of the recent plant, made in the proportion of 3 viij. to alco- nol 76, Oj.; using pressure to remove the fluid. It will be well to commence with the fraction of a drop as a dose, say- R Tincture of anemone, gtt. x., water 3iv.; a teaspoonful every two to four hours, gradually increasing as we feel our way. 7 74 SPECIFIC MEDICINES. ANTIMONII ET POTASSII TARTRAS. (TARTAR EMETIC.) I should not recommend the use of this drug except in very minute doses, and it is best dispensed in a Homœopathic trituration, from the first to the tenth decimal. Of either of these from one to five grains may be added to a half glass of water, of which the dose will be a teaspoonful. The simplest indication for the minute dose of this remedy is increased secretion of the respiratory mucous membrane. To this may be added, a feeble pulse, pallid skin, cool extrem- ities, cold sweats, uneasiness in the lower abdomen, and fre- quent desire to go to stool and urinate. If we were giving it in the old fashioned dose, the indications would be the reverse of this. It is successfully used in croup, bronchitis with free secretion, in broncorrhoea, humoral asthma, and in pneu- monia with abundant secretion. APOMORPHIA. Apomorphia is a white or grayish white powder obtained from heating hydrochlorate of morphia with hydrochloric acid. Care must be used in preserving it, as it changes readily by slight exposure, It is soluble in water. This agent produces emesis in very small doses, even the one sixtieth of a grain by hypodermic injection producing copious vomiting in ten minutes. Hence it has been suggest- ed as an emetic in cases of poisoning, when the ordinary emetic could not be given, or would not produce emesis. effects are very depressing. APOCYNUM CANABINUM. (INDIAN HEMP.) Its Of Preparation. The preparation I prefer is, an alcoholic tincture, representing the crude article, ounce for ounce. such tincture, the dose will vary from the fraction of a drop to ten drops, as the maximum. If the physician prepares his tincture, it should be from the recently dried root, in the proportion of 3 viij. to alcohol 76, Oj. APOCYNUM CANABINUM. 75 It is probable that Apocynum Androsæmifolium possesses identical properties, and as the distinction is recognized with difficulty, even by those most conversant with botanic medi- cines, they have been used indiscriminately. The Apocynum is a true specific for that atonic condition of the blood-vessels that permits exudation, causing dropsy. I have employed it in my practice for some eighteen years, and it has not failed me in a single case, where the diagnosis was well made. It is a positive remedy for dropsy, whether it takes the form of œdema, anasarca, or dropsy of the serous cavities, where there is no obstruction to the circulation, and no feb- rile action. We would not expect to effect a cure in dropsy from heart disease, or ascites from structural disease of the liver, neither would we where there was a frequent, hard pulse, and other evidences of febrile action. Still in these cases, if we can partially remove the obstruction in the first case, and after an arrest of febrile action in the second, the Apocynum will remove the deposit. It is not worth while to inquire how it removes dropsical accumulations. It seems to strengthen the circulation, and as absorption takes place there is an increased flow of urine. I have also employed the apocynum in cases of passive menorrhagia with advantage. It may be especially recom- mended in those cases in which the flow is constantly too profuse, too long, and too frequently repeated. I use it with water, in the following proportion: R Tincture of Apocynum, gtt. v. to x.; water, 3iv.; a teaspoonful every three hours. Latterly it has been used as an anti-rheumatic, with ex- cellent results in some cases. With this, as with many other remedies, there are special symptoms indicating its use. If these are found in any disease, the remedy becomes specific. Thus in rheumatism, if there is a tendency to oedema, even slight puffiness of the skin, or a peculiar blanched glistening appearance, the Apocynum will be found a valuable remedy. Following these indications I have used it with excellent 76 SPECIFIC MEDICINES. results in some chronic diseases, especially where pain was a prominent symptom. I have already spoken of it as a remedy for menorrhagia. It will also be found a valuable remedy in chronic metritis, with uterine leucorrhoea. In one case with profuse watery discharge from the uterus, it proved curative after other plans of treatment had failed. ARALIA HISPIDA. (DWARF ELDER.) The dwarf elder has been extensively and successfully em- ployed in dropsy. The infusion has usually been employed, and given freely. I would suggest a tincture of the recent bark, in dilute alcohol, and in the proportion of 3 viij. to the pint; dose, gtt. j. to x. I have employed it to but a limited extent, yet with good results. It has a very positive influence on the circulation, and upon secretion. Does it not act on them through the sympathetic nervous system? and may we not influence all the vegetative functions with it, as we do with some others? It is deserving thorough investigation. ARGENTUM NITRICUM. (NITRATE OF SILVER.) Nitrate of silver may be combined with the proper excip- ient, as extract of liquorice, and given in the form of a pill. It undoubtedly influences the cerebro-spinal centers, con- trolling epileptiform movements. It has been administered in cases of epilepsy with success, though the discoloration of the skin caused by the large doses given, was a serious objec· tion. It also exerts an influence in chronic gastritis and enteritis, and has been given in some cases of dysentery with advantage. Administered in doses of one-twentieth to one- fourth of a grain. ARNICA MONTANA. 77 ARANEA DIADEMA. (CROSS SPIDER-SPIDER'S WEB.) Our Homœopathic friends prepare a tincture by putting the living creatures in strong alcohol. We prefer a tincture of spider's web, in the proportion of 3ij. to strong alcohol Oj. It has been employed in ague and malarial disease, when there was marked confusion of intellect, 'with headache and burning of the face and eyes. In ague the chill is prolonged, with great pain in the bones, and a feeling as if bruised. Dose, from the fraction of a drop, or a dilution, to gtt. x. ARISTOLOCHIA SERPENTARIA. (VIRGINIA SNAKE ROOT.) Prepare a tincture from the recent root, using alcohol of 98 per cent. Dose from the fraction of a drop to five drops. In large doses it has been extensively used as a stimulant diaphoretic, and is a most excellent remedy. In small doses it is indicated by a relaxed atonic skin, cold extremi- ties, cold perspiration, difficult respiration, and difficult deglutition. It may be combined with the sedatives in the eruptive fevers. ARNICA MONTANA. (ARNICA.) Preparation.-Prepare a tincture from the recent flowers, 3 viij. to alcohol 76, Oj. Dose, the fraction of a drop. It is not necessary to refer to the common local use of this agent, or discuss the question whether a tincture of arnica is preferable to alcohol alone as a local application. Every one has employed it in this way, and each one has formed his own opinion. I think its local use is valuable, but greatly over- estimated. Can it be employed as an internal remedy with advantage? I am satisfied that it can. It is a valuable stimulant in many grave diseases where a stimulant is most required. But if used as a general stimulant, like alcohol, it would be as apt to do harm as good. 78 SPECIFIC MEDICINES. It is a specific stimulant to the spinal nervous system, and will be found useful where there is want of innervation from this. I have seen most marked benefit from it in advanced stages of disease, where there was feeble respiratory power; difficulty of sleeping from impeded respiration; want of con- trol over the discharge of urine and feces, etc., evidences of impairment of spinal innervation. In such cases its bene- ficial influence may be noticed in a few hours. I have frequently prescribed it for lame back, back-ache, and feelings of debility and soreness, in the small of the back. It is only useful in those cases where there is feeble- ness, with deficient circulation; but in these the influence is direct and permanent. Recently it has been employed in the treatment of pneu monia with good results. The cases reported, so far as I can learn, were asthenic with an enfeebled circulation. It was employed alone in doses of five to ten drops every three hours. ARSENICUM. (ARSENIC.) Arsenic is one of the agents that Eclectics have objected to, on the ground that it, like Mercury, was a depressant, and should be classified as an antiphlogistic. The use of Arsenic in the early part of this century, though limited, was in large and many times poisonous doses. Being a powerful excitant to the vegetative nerves, this use, if continued long, would produce a peculiar form of fever-"febris arsenicum" -with its attendant impairment of vital function. Finally, with impaired blood-making and nutrition, there would be developed arsenical dropsy, and in some rare cases death was the result. The arsenical fever bears a very close resemblance to quin- ism, or quinine poisoning, in its symptoms, though there is not, in a majority of cases, such disturbance of the nervous system. There is also a difference in the termination, for whilst in quinism there is continued dryness of skin and scanty high colored urine, and finally death from uræmia, in ARSENICUM. 79 chronic poisoning by Arsenic there is finally a stage of re- laxation, and though there is dropsy, the skin and kidneys act freely. We have long since determined that the mere matter of dose in medicine might be the difference between a poison and a remedy. If, for instance, we give one grain of Strych. nia, we poison our patient, whilst if the dose had been but the fortieth or thirtieth of a grain, it would have proven a vital stimulant. If we administer five grains of morphia, the result is death; whilst a medicinal dose of one-fourth of a grain would have produced refreshing sleep. If we give large doses of Aconite, (say five drops of a tincture of the root,) frequently repeated, it increases the frequency of the pulse, impairs the circulation, and irritates the nervous sys- tem. But, in medicinal doses, it lessens the frequency of the pulse, gives freedom to the circulation, and relieves irritation of the nervous system. If we give large doses of Veratrum, it impairs the circulation, arrests vital processes, and pro- duces death; whilst medicinal doses give increased freedom to the circulation and diminish the frequency of the pulse. It seems strange to me that these things have not had due consideration, and that the remedial action of drugs has not been kept distinct from their poisonous effects when given in large doses. We have already seen, that the dose of medicine should be the smallest quantity that will give the desired in- fluence, and that in a rational system of medicine, its influ- ence should always be to restore normal function, and not as a disturbing element. There is another view of this subject which is important in this consideration. A drug which may be poisonous in health, or in some conditions of disease, will be curative in other conditions of disease. Thus we regard the disease as antagonizing the remedy, quite as much as the remedy antag- onizes the disease, and the influence is toward the restora- tion of healthy function. Give a healthy man almost any of our common medicines, and after a time he will become dis- eased, the disease being of that kind and of that part which 80 SPECIFIC MEDICINES. the medicine cures. Thus, if we give Quinine to cure mala- rial fever, its influence is kindly, but if there is no malarial disease, it causes irritation of the nervous system. If we give Belladonna when there is an enfeebled capillary circula- tion, the influence is kindly and curative, but it is the re- verse if we already have capillary spasm. This is especially the case with the more powerful remedies, with which Arsenic should be classed, and they should never be employed unless the symptoms indicating them are very distinct. Such a brief statement of facts I have deemed necessary in this case, on account of the prejudice of our school to these agents-a prejudice which grew out of their abuse. This prejudice is so strong now, that one hardly dare risk making a study of the tabooed articles, and yet common honesty de- mands that it be done. In small doses, and when indicated, Arsenic may be re- garded as a vital stimulant, and one of the most powerful of this class. But we must not forget that the dose must be small, and there must be special indications for its use. What are these indications? In that condition of the blood, and of nutrition, where there is a tendency to the deposit of a low or imperfect albu- minoid material-yellow tubercle, caseous deposits-or de- generation of tissue, Arsenic may be used as a blood-maker, and especially to improve nutrition. A class of skin diseases depending upon such deposits, or on enfeebled nutrition, is cured by Arsenic. Among these are the more chronic affections—the squamæ, the chronic vesiculæ, some of the pustulæ, and the tuberculæ. It will not cure all cases, it will do harm if injudiciously used, but it affords relief in many otherwise intractable. But, it should never be employed where there is irritability of the nerve centers, and especially of the sympathetic. This rule I think is absolute, and must be constantly regarded. Arsenic is a nerve-stimulant; quite as much so as phosphorus, with this addition—that its action is greatly intensified when there is already erythism of the nerve centers. ARSENICUM. 81 It has been successfully employed in some cases of phthisis, presenting the condition above named. Prof. Howe uses it in combination with Veratrum, and there is no doubt that this renders the system tolerant of Arsenic where it could not otherwise be employed. Arsenic is topically employed to destroy malignant growths. The majority of the cancer specialists" use it in some form, and their preparations differ only in the inert material with which it is combined. The preparation now employed most frequently is made as follows: Take Hydrated Sesqui- oxide of Iron a sufficient quantity, throw it on a paper filter, and when of the consistence of an ointment, add an equal part of Lard. To this add Arsenious Acid, in the propor- tion of 3ss. to 3j. to the ounce. Arsenic may be employed in the treatment of some cases of intermittent fever with excellent results. They are those marked by impairment of sympathetic innervation, and with a general want of nervous excitability. The dose should be very small, gtt. v. to x. of Fowler's Solution to iv. of water; a teaspoonful every two or three hours. I have used the Homoeopathic pellets, medicated with Fowler's Solution, and though the dose was not more than the twentieth to the one- hundredth of a drop, the effect was marked, where specially indicated. It is also used with advantage in atonic diarrhoea, with in- digestion, the conditions being as above named. Especial benefit has been observed in those cases in which there were periods of great depression, followed by hectic fever. I need hardly say in conclusion, that Arsenic is one of those agents that will do either good or harm. Good if given in a proper case, and in medicinal doses; harm if not indica- ted by special symptoms, or contra-indicated as above named, or if given in poisonous doses. Fowler's Solution is a preparation to be preferred. Dose from the fraction of a drop to two drops. 82 SPECIFIC MEDICINES. 2 ARUM TRIPHYLLUM. (INDIAN TURNIP.) Prepare a tincture from the recent root, using alcohol of 98 per cent. The dose will be of gtt. x, to water 3iv., a tea- spoonful every hour. It is indicated by hoarsenes and loss of voice, with burning and constriction of the throat, sneezing, and thin ichorous discharge from the nose. Our Homoeopathic friends say that a "keynote" for this remedy is "children pick the nose and chin persistently." ARTEMESIA ABSINTHIUM. (WORMWOOD.) Preparation. For experiment, I would suggest a tincture with dilute alcohol, 76 per cent., in the proportion of 3 viij. to the pint; vary the dose from one drop to one drachm. This agent has been used principally as a vermifuge, but lately it has given place to the Chenopodium and to Santo- nine. It possesses very decided medicinal properties, how- ever, and deserves a thorough examination. It influences the nervous system, especially the sympathetic. ARTEMESIA SANTONICA. (WORMWOOD.) We only wish to consider the crystalizable principle- santonine-here. Its principal use has been as a vermifuge in cases of ascaris lumbricoides, for which it has been found quite efficient. But in using it for this purpose many have noticed that it exerted a peculiar influence upon the brain, and upon the eyes-rendering objects blue, yellow, or green; and that it passed off in the urine, giving it a peculiar color. It exerts a specific action upon the bladder and urethra, stimulating contraction of the first, and allaying irritation of the second. It is especially valuable in cases of retention of urine in children during protracted disease: in doses of half to one grain, it is prompt and certain. I have also em- ASCLEPIAS. 88 ployed it to relieve irritation of the urethra, especially in women suffering from uterine disease, and with good success. Its influence upon the nervous system needs to be studied. I judge it to be a nerve stimulant, and have employed it for this purpose to a limited extent. APIS MELLIFICA. (HONEY BEE.) The honey bee possesses marked medicinal properties, but from a prejudice against such remedies, has been but little employed. An infuison of twelve to twenty honey bees in a pint of boiling water, is one of the most certain diuretics I have ever employed in cases of suppression of urine from atony. It is also a very efficient remedy in retention of urine, and in some cases of irritation of the urethra. I have used the tincture for the same purpose, and also for inflammation of subcutaneous structures, with tensive and lancinating pains, and in irritation of the skin. I have pre- pared my own tincture, in the proportion of 3j. to alcohol 98 per cent. Oj. Dose one or two drops. I have seen a number of cases of disease in women charac- terized by sensations of heat, and burning pains in the blad- der and course of the urethra, with frequent desire to mic- turate. These have been. promptly relieved by the use of tincture Apis, and in two cases of chronic disease of long standing, a permanent cure was effected, following the relief of these unpleasant symptoms. : ASCLEPIAS. (SILK WEED.) Preparation. The best preparation for experiment will be a tincture of the recent root, in the proportion of 3 viij. to alco- hol 76 per cent. Oj.; note its effect in small as well as large doses. The A. Incarnata, A. Syriaca, etc., deserve a careful inves- tigation. In weak infusion they all prove diaphoretic, and to 84 SPECIFIC MEDICINES. some extent diuretic. It is claimed by those who have made considerable use of them, that they stimulate all the secre- tions. ASAFOETIDA. Whilst I think but little of this foetid gum as an anti-spas- modic, I regard it as a valuable gastric stimulant, and also as a nerve stimulant. In nervous dyspepsia, especially, it will be found valuable. The following is a good form: R Asafoetida, 3ss.; hydrastine, 3ss.; aloes, grs. x. Make thirty pills, and give one three times a day. As a nerve stimulant I have used & Extract of Nux Vomica, grs. x.; Asaf., grs. xl. Make twenty pills, and give one at night. ASCLEPIAS TUBEROSA. (PLEURISY ROOT.) Preparation. Whilst I prefer a tincture made from the recent root, I have used a tincture of the dried root, made to represent ounce for ounce; the dose being from one drop for a child two years old, to ten drops for an adult. It is especially a child's remedy, being feeble in action, though quite certain. When given freely, it is one of the most certain diaphoretics we have, providing the pulse is not frequent, and the temperature increased. Even in the small dóse of one drop, following the use of the special sedatives, it will markedly increase the true secretion from the skin. Recollect that there is a difference between sweating and secretion. There may be a profuse exudation of water, the surface being bathed in perspiration, and yet but little secre- tion. Excretion by the skin is a vital process, and takes place by means of secreting cells. It goes on best where the skin is soft and moist, and not when covered with drops of sweat. I employ Asclepias in diseases of children, believing that it allays nervous irritability, is slightly sedative, and cer- tainly increases the secretion from the skin. I use it with Veratrum and Aconite, in febrile and inflammatory diseases, ATROPA BELLADONNA. 85 and in mild cases, very frequently give it alone. Bear in mind that it is a feeble remedy, and too much must not be expected. ASPIDUM FILIX MAS. (MALE FERN.) This agent is only used as a vermifuge, especially for the removal of tape worm. For this purpose the ethereal oil is used in doses of twenty drops to one drachm. ATROPA BELLADONNA. (BELLADONNA.) Preparation.-Whilst for some purposes a solution of the alkaloid, Atropia, will prove the best preparation, I prefer, for general use, an alcoholic tincture of the recent plant, rep- resenting the crude article ounce for ounce. Of this the maximum dose will be one drop, but frequently one-fifth to one-half of this will serve a better purpose. For hypodermic use, we employ a solution of Atropia, in the proportion of one grain to the ounce of distilled water. The dose would be five to ten drops. This is also the best proportion for use to dilate the pupil. As a collyrium, we would add 3j. of this solution to 3j. of distilled water. The specific use of Belladonna is as a stimulant to the cap- illary circulation, especially of the nerve centers-a remedy opposed to congestion. My attention was first drawn to it by an article from Brown-Sequard, giving the results of his ex- periments with the drug, stating that with the microscope he had seen marked contraction of the capillaries following its use. It at once suggested itself to me, that if it would cause capillary contraction, it would be the remedy for congestion; and I at once commenced experimenting with it in this di- rection I well recall my first marked case: a boy about eight years old, suffering from malignant rubeola. The entire surface was swollen and dusky; the eyes dull; the pupils dilated; the face expressionless; breathing labored, and wholly uncon- 86 SPECIFIC MEDICINES. • scious for forty-eight hours. The administration of Bella- donna alone (in small doses) was sufficient to restore con- sciousness, and a free circulation, with good appearance of the eruption, in twenty hours. The evidences in its favor rapidly accumulated, so that in eighteen months I used it with a feeling of almost certainty for this purpose. Whilst it exerts the same influence on all persons; and at all ages, the true pathological condition being determimed, it is especially valuable in treating diseases of children. In the young, the immature nervous centers suffer more severely, and we find the opposite conditions, of irritation with deter- mination of blood, and atony with congestion. The symptoms calling for the use of Belladonna are usually very plain the patient is dull and stupid-and the child drowsy, and sleeps with its eyes partly open; the countenance expressionless; the eyes are dull, and the pupils dilated, or immobile; whilst as it continues respiration becomes affected, and the blood imperfectly aerated. In these cases I prescribe Belladonna: in the adult, in the proportion of gtt. v. to gtt. x., to water 3iv.; in the child gtt. v. to iv.; in each a teaspoonful every hour. As these are mostly febrile cases, or at least have a feeble, frequent circulation as an element, I give Aconite in the usual doses. 1 Belladonna is also a specific in incontinence of urine. Not that it will cure every case, but those in which an enfeeble- ment of the pelvic circulation is the principal cause. Pro- bably a lesion of the spinal cord has also much to do with it. Of course, it gives no relief where the incontinence arises from vesical irritation. The dose in this case will be the same as above named, but only repeated four times a day. Belladonna is also a specific in diabetes insipidus; even a Belladonna plaster across the loins being sufficient in many cases for its arrest. Belladonna is undoubtedly a prophylactic against scarlatina, as I have thoroughly proven in my practice. Recollect, how- ever, that it is only prophylactic in small doses; in doses suf- AURUM. 87 • ficient to produce dilatation of the pupil, it has no such in- fluence. Belladonna has other special uses, but they may be briefly summed up: if in any case there is an enfeebled circulation, with stasis of blood, Belladonna is the remedy. Of course, acting upon some parts more directly than others, its influence will be more decided, but there is no case, with condition as above, in which it will not be beneficial. I may say in conclusion, that we want a good preparation of the recent herb; and then it must be used in small doses to obtain the influences named. The doses given are the maximum. As we have had occasion to say before, the drug- gists care little about the quality of medicines sold; they are simply articles of merchandise, and there is little, if any, professional esprit with them, to aid us in having them good. Therefore every physician must be on his guard when pur- chasing, and had better buy of first hands, and of those of proven honesty. ous. AURUM. (GOLD.) The preparations of gold have nearly the same properties as those of mercury, and in large doses are intensely poison- Thus the chloride of gold is more active than corro- sive sublimate. The preparation of gold advised, when it is thought necessary to use a remedy of this character, is the chloride of gold and sodium. It may be given in doses of one-sixtieth to one-twelfth of a grain, in solution, and in most cases it is well to combine a small portion of Phytolacca. with it. It is indicated by a moderately red tongue, good circula- tion to the surface, the patient suffering with secondary syph- ilis, glandular disease, or chronic disease of the skin. 88 SPECIFIC MEDICINES. BAPTISIA TINCTORIA. Preparation.-The Baptisia has been principally employed in infusion, but as this is inconvenient in many cases, I would recommend a tincture by percolation, using 3viij. of the bark of the root to Oj. of Alcohol of 98 per ct. Of an infu- sion of 3j. to 3iv. of boiling water, the dose is one teaspoon- ful; of the tincture as named, gtt. x. to water Živ., dose, a teaspoonful. The specific indication for Baptisia is a dusky purplish color of face, like one who had been exposed to cold, face ex- pressionless; there is a similar color of tongue, fauces and throat. Occasionally we find this unpleasant discoloration over an affected part, as the chest, liver, etc., and sometimes the entire surface of the body is thus discolored. With some the Baptisia has been a favorite remedy for sore mouth and sore throat, using it locally, and for this pur- pose it is one of the most valuable remedies we have. I judge, however, that if you should ask, in what particular variety of sore mouth or throat it was found best? you would have difficulty in getting an answer. It is in those cases in which there is enfeebled capillary circulation, and tendency to ulceration, that it is specific That is, the condition is one of atony, with tendency to mole- cular death and decomposition. The remedy is, therefore, stimulant and antiseptic. It may be employed with the greatest certainty in any form of sore mouth or throat presenting the characteristics named. Especially in stomatitis ulcerata, or cancrum orris, in cynan- che maligna, and in the sore throat of scarlatina maligna; but it is not only a good local application in these cases, but a most valuable internal remedy. It is specific to the condition upon which such sore mouth and throat is based, whether it is manifested in this way, or in ulceration of Peyer's follicles in typhoid fever. Thus I have employed it with very marked advantage, in all cases showing putresceny, and tendency to softening and breaking down of tissue. BEBEERINE SULPHAS. 89 It is not a remedy for acute inflammation, whether erythe- matous or deep seated, and in ordinary stomatitis or cynan- che, it is not a remedy. In diphtheria presenting acute in- flammatory symptoms, it is worse than useless. But in diph- theria with swollen and enfeebled mucous membranes, dusky or livid discoloration, or blanched appearance, with tendency to ulceration and sloughing, there is no remedy more certain. I have successfully employed the Baptisia in typhoid dys- entery, as have others. But as will be seen, this is but the condition named above for its specific action. So long as there is an acute inflammation, with stools of blood or pure mucus, it is not beneficial, but when the discharges resem ble prune juice, the washing of meat, or are muco-pur- ulent,” with general symptoms of an analogous character, then it becomes one of our most certain remedies. BARII CHLORIDI. (CHLORIDE OF BARIUM.) The preparation advised is the officinal solution U. S. P. of which ten drops may be added to water 3iv., and administered in doses of one teaspoonful every three or four hours. In its action upon the economy this remedy has some re- semblance to arsenic, and is indicated by an inelastic dirty skin, enlarged lymphatics, and feeble respiration. It has been employed as a remedy in cancer, scrofula, and in scrofulous phthisis. It has been deemed of especial value in scrofulous inflammation of eyes, ears, and testes. BEBEERINE SULPHAS. This is not the so-called Berbeerin from the Berberis Vul- garis, or Hydrastis, but a well-defined salt from the Nectan- dra Rodiæi. As found in commerce, it is in glittering scales of a brownish-yellow color, and when triturated forms a yel- lowish powder. It exerts a specific action upon the uterus, but thus far it has been principally employed in cases of menorrhagia. In 8 90 SPECIFIC MEDICINES. • this case its influence is very marked, controlling the hemor- rhage, and preventing its recurrence. As we have other rem- edies for the milder cases, its use might be confined to those in which there is profuse discharge at each menstrual period, and when they recur too frequently. The dose will be from half to three grains every three or four hours. BELLADONNA. (See Atropa Belladonna.) BENZOIC ACID. I prefer to use benzoic acid in solution in alcohol, 3j. to the Oj., to the tincture of benzoin, though the latter will an- swer the purpose. The dose will vary from ten to sixty drops, according to the effect desired. Its first use is in irritable bladder, with deposits of uric acid or triple phosphates; in either case its use will prove beneficial. Its second use is in irritation of the sympathetic and spinal system of nerves, with uric acid deposits. Its third use is as a stimulant to the brain in cases of ex- haustion, with phosphuria. I have used it in this case, alter- nated with a preparation of phosphorus-either the phospho- retted oil or the tincture-with advantage. These are usu- ally cases of exhaustion from over-exertion of the mind, as frequently met with among our business men. BENZOATE OF SODA. A Recently benzoate of soda has been recommended by Ger- man physicians as a specific in phthisis pulmonalis—the rem- edy in solution to be used with an atomizing apparatus. solution of two drachms in five ounces of water was used daily for some weeks. Later reports contradict the asserted curative influence, and the results in this country have not been satisfactory. BISMUTH. 91 It has also been recommended in the treatment of diph- theria, scarlatina, cynanche maligna, and zymotic dysentery. I am inclined to believe that it will be found a good remedy in nephritis and albuminuria, the tongue being pallid. BENZOATE OF LITHIA. I administer benzoate of lithia in solution, ten grains being added to water 3iv., of which the dose will be from a tea to a tablespoonful four times a day in a glass of water. It is indicated by deep-seated pains in the loins, pain in, the small of the back, uneasiness in the bladder, with fre- quent desire to pass urine, and deposits of uric acid. BERBERIS VULGARIS. (BARBERRY.) A tincture of the recent bark, in the proportion of 3 viij. to alcohol 76 per cent. Oj., is suggested. Dose varying from ten drops to one drachm. Will some of our Eastern practitioners give us their ex- perience with this agent; or if it has not been employed alone, will some one test it thoroughly. Evidently it has an influ- ence upon the gastro-intestinal mucous membrane, and pro- bably on associate viscera. BISMUTH. We employ Bismuth in two forms. The subnitrate in doses of from one to two grains; the liquor Bismuth (solution of citrate of bismuth), in doses of from gtt. x. to 3j. The first use of Bismuth is to allay irritation of the gastro- intestinal mucous membrane; and for this purpose it has been extensively employed. Usually the sub-nitrate in impalpa- ble powder, is employed in small doses frequently repeated for gastric irritation, and in doses of five to ten grains for in- testinal irritation, with diarrhoea. The second may be called its specific use, for chronic gastro- intestinal irritation, or dyspepsia with diarrhoea. Here I 92 SPECIFIC MEDICINES. 1 employ the liquor bismuth in doses of from a half to one tea- spoonful four times a day. In inveterate cases, not amenable to other treatment, and of years' duration, I have had the happiest results. I have omitted to name the common use of Bismuth for water-brash, in some cases of which it is very effectual. The powdered sub-nitrate is also a most effectual local ap- plication for irritation of the skin-chafing—either in the in- fant or adult. For this purpose the part is thoroughly dusted, and it is repeated as often as necessary to keep it dry. BIDENS BIPINNATA-CONNATA-FRONDOSA. (SPANISH NEEDLES.) Preparation.-Prepare a tincture from the recent herb, in the proportion of 3 viij. to alcohol 76 per cent. Oj., using pres- sure. Dose from five to thirty drops. The different varieties of Bidens deserve investigation. Reference to the Dispensatory or Materia Medica will give the direction it should take. I am especially interested in the action of the B. Frondosa on the heart and circulation. BOLDO. Boldo leaves are the product of an evergreen shrub in Chili; they are of a reddish-brown color, have a fragrant odor and a pungent aromatic taste. Though largely advertised as a new remedy, it is not likely to take a very prominent place in medicine. It has been re- commended and used in anemia, dyspepsia, and nervous de- bility, the remedy being stimulant to the digestive apparatus and nervous system Of a good tincture the dose will be from two to ten drops. BORAX. We employ a solution of Borax as an antiseptic dressing in wounds, injuries, and surgical operations, the strength being from 3j. to 3iv. in water Oj. It is employed as a topi- BROMINE. 93 cal application to mucous membranes when there is an ap- thous condition or exudation, and is equally applicable in acute or chronic disease. Internally it may be administered in small doses (grs. j. to v. in water ziv.) in persistent sore mouth; dyspepsia with sense of constriction; gnawing pain; uneasy stools; frequent desire to pass urine, the last part of the discharge being mu- co-pus; dragging pain in back, and acrid leucorrhoea. BROMINE. Bromine is not employed as an internal remedy, though its salts have been used largely within the last ten years. It may be employed with advantage as an inhalation in croup and diphtheria, and as a stimulant in phthisis. For croup it has been used in the proportion of ten drops to two ounces of water. BROMIDE OF POTASSIUM. Bromide of Potash is a very greatly overestimated remedy. When I commenced practice it was only used in cases of spermatorrhoea to relieve sexual irritation—now it is recom- mended for every nervous ill that flesh is heir to. I think it has one specific use, and that is as a remedy for epilepsy when associated with irritation of the reproductive organs, or especially in irritation of the cerebellum. In such cases I have used it with much success. The dose will be about twenty grains three times a day. I only use it in spermatorrhoea, in those cases in which the person is of a plethoric habit, with great venereal excitement -cases approximating satyriasis, rather than spermatorrhoea. In these I administer it in doses of thirty to sixty grains at bed-time. BROMIDE OF AMMONIUM. (See Ammonium.) 94 SPECIFIC MEDICINES. BRYONIA. We employ the German tincture of Bryonia in the propor- tion of gtt. v. to gtt. xxx. to water 3iv.; a teaspoonful every one, two, or three hours. The most marked symptom indicating its use, that I have noticed, is a dusky flushing of the cheeks, especially over the right malar. Pain in the right side of the face and head, burning in eyes and nose, with acrid nasal discharge. The pulse is full and hard, urine scanty, and bowels constipated. With the first symptom named I should prescribe it in any form of disease, though it is used most frequently in rheu- matism, pneumonia and catarrhal affections. If in disease the person has a short cough, or makes an effort to free the lungs, no disease of air passages being pres- ent, we would think of Bryonia. So if there is pain in se- rous membranes, or pain simulating this, the remedy is sug- gested: thus in rheumatism involving the synovial membranes we would be likely to prescribe this remedy. BURSA PASTORIS. (SHEPHERD'S PURSE.) A tincture is made in the usual way, using 3viij. of the recent herb to alcohol 98 per cent. Oj. The dose will vary from the fraction of a drop to fifteen drops. It may be employed in chronic menorrhagia where the menstrual discharge occurs too frequently or continues too long, or when the discharge is almost constant but colorless. There is a frequent desire to pass urine, and a deposit of phosphates. It has also proven a remedy in dyspepsia and chronic diarrhoea. CACTUS GRANDIFLORUS. (NIGHT-BLOOMING CEREUS.) Preparation.—We prepare a tincture from the recent plant, in the proportion of 3iv: to alcohol 98 per cent. Oj. The dose will vary from the fraction of a drop to two drops. CACTUS. 95 4 The influence of Cactus seems to be wholly exerted on the sympathetic nervous system, and especially upon and through the cardiac plexus. In does not seem to increase or depress innervation, (neither stimulant nor sedative), but rather to influence a regular performance of function. I am satisfied, however, that its continued use improves the nutrition of the heart, thus permanently strengthening the organ. It has a second influence, which is of much importance to the thera- peutist. It exerts a direct influence upon the circulation and nutrition of the brain, and may thus be employed with advantage in some diseases of this organ. We can see very readily how this may be. The cardiac nerves are derived from the upper part of the sympathetic, and, judging from the anatomy of the part, the first cervical ganglion being the principal nervous mass in the cervical region, must furnish innervation through the cardiac nerves, as it certainly con- trols the circulation and nutrition of the brain. The Cactus is a specific in heart disease, in that it gives strength and regularity to the innervation of the organ. Its influence is permanent, in that it influences the waste and nutrition of the heart, increasing its strength. It exerts no influence upon the inflammatory process, and hence is not a remedy for inflammatory disease. Feelings of weight and pressure at the præcordia, difficult breathing, fear of impending danger, etc., are at once re- moved. Such irregularity of action, whether violent, feeble, or irregular, as is dependent upon the innervation, is readily controlled. Thus, in the majority of cases of functional heart disease, it gives prompt relief, and, if continued, will effect a cure. In those cases in which there is another lesion act- ing as a cause, as in some gastric, enteric, or uterine lesions, these must receive attention, and be removed to make the cure radical. In structural heart disease, the first use of remedies is to relieve the distressing sensations in the region of the heart, and the unnatural fear of danger which attends them. As these spring from disordered innervation, in the majority of J 96 SPECIFIC MEDICINES. cases, the Cactus gives prompt relief. As we have seen above, its continuance favors normal waste and nutrition, as well as regular action. Hence, its continued use is followed by the removal of adventitious tissue, and an increase in the strength of its contractile fibre. Thus it proves curative in many cases of structural heart disease. I have some cases on my case-book of such aggravated form that no one would believe they could live a twelve- month; yet, after a lapse of five years, they are enjoying com- fortable health. But it will not relieve or cure cases of valvular deficiency, dilatation of the openings of the heart, or fatty degeneration. It is well, in estimating its action, to bear this in mind. In its influence upon the nervous system, it more nearly resembles Pulsatilla; giving relief in that condition known as nervousness. But further than this, it gives regularity of cerebral function, and permanently improves nutrition of the nervous centers. CADMII SULPHAS. Sulphate of cadmium is a very powerful remedy, and must be used with great care. As a collyrium it may be used of the strength of one to two grains to the ounce of water; as a wash in otorrhoea, and as an injection in gleet, the strength may be five grains to the ounce of water. As an internal remedy I would employ a solution of one grain to sixteen ounces of water, of which the dose would be a tea-spoonful. It would be indicated by nausea, vomiting, colic, giddiness, feeble pulse and respiration; mental anxiety would be a prominent symptom. CAHINCA. Prepare a tincture from the root in the usual way, using alcohol of 98 per cent. From gtt. x. to 3ij. is added to water Ziv., of which the dose is one teaspoonful. It may be administered when the urine is scanty, and the patient complains of a sense of weight and fullness in the loins; and is also indicated by œdema of feet or fullness of CALENDULA. 97 eye-lids. It has been employed as a remedy in dropsy, the dose being larger than the one named. CALCII CHLORIDUM. (CHLORIDE OF LIME.) As a disinfectant fresh chloride of calcium has but few superiors, and its moderate use in cleaning the chamber uten- sils, mixing with the discharges, and to freshen the air of the sick chamber, is to be commended in all zymotic diseases. It is especially recommended to be employed in this way in typhoid fever, the discharges from the bowels carrying the germs of the disease. As an internal remedy it is to be recommended when the patient has a bad breath, tongue dirty with pasty coat, en- largement of lymphatic glands, and slow inflammations with cacoplastic deposits. The dose need not be large; 3j. of the fresh chloride to water Oj. kept tightly corked, may be given in doses of a teaspoonful or tablespoonful in a wine-glass of water. CALCII SULPHIS. (SULPHITE OF CALCIUM.) In doses of one grain the sulphite of calcium exerts a marked influence in controlling inflammation of connective tissues, especially the superficial, as in furuncles, or boils. It also improves digestion, nutrition, and waste. The atten- tion of readers is especially called to this remedy. CALENDULA. (MARIGOLD.) Prepare a tincture from the fresh plant, using alcohol of 98 per cent. Added to water in the proportion of 3j. to 3j. in water Oj it has proven an excellent application to wounds or injuries, when the patient has the burning pain of an incised wound. Internally, in the proportion of gtt. x. to water 3iv. it may be given in congestion of the liver or other viscera, the 9 98 SPECIFIC MEDICINES. patient complaining of sensations of weight, fullness and dragging CALX, (LIME.) Lime is used for the ordinary purpose of an antacid, and in some cases is preferable to any other alkali. This is espe- cially the case in indigestion, with the formation of lactic acid from decomposing food. Here there is not unfrequently an excess of the normal salts of the blood, and we can not use the salts of soda and potash to neutralize gastric acidity. It may be stated, as a general rule, that it will be found ben- eficial in cases of infantile dyspepsia, and in dyspepsia of the adult with acid eructations during digestion. Its specific use is in cases of furunculus or boils, and other inflammations of cellular tissue, terminating in suppuration. Why it has this specific influence I do not propose to say, but the fact I have proven in scores of cases. Given, a case in which boils are being continually developed, the use of lime-water will effect a radical cure. It is given in doses of a wine-glassful three or four times a day. CANNABIS SATIVA. (INDIAN HEMP.) The tincture of Cannabis should be prepared from the re- cent wild plant whilst in flower, but as we can not get this, we use a tincture prepared from the churrus, a species of ex- tract from the recent plant, imported from India. The dose will vary from the fraction of a drop to five drops. In small doses it is stimulant to the cerebro-spinal centers; in large doses it produces intoxication, and finally arrest of function. It exerts an influence upon the urinary and repro- ductive apparatus that may be rendered available in practice, and also to some extent upon the skin. I have employed the Cannabis specially to relieve irritation of the kidneys, bladder, and urethra. It will be found bene- ficial in vesical and urethral irritation, and is an excellent remedy in the treatment of gonorrhoea. CAPSICUM. 99 I do not like it as a remedy for intemperance, (chronic alcoholism), so well as a combination of nux vomica and iodine, with a bitter tonic; though in some cases it may be used with marked advantage, and the habit finally broken up. CAMPHOR. Camphor in small doses is a stimulant, in large doses a sed- ative, to the nervous system. I do not regard it as having a very extended use in medicine, though for the purpose named, it may sometimes be employed with advantage. In low forms of disease, with insomnia and restlessness, I have used it alone, and in combination with stimulant doses of opium or morphia, and quinine. As a topical stimulant, it may be employed with advantage, when the integrity of the part is threatened from enfeebled circulation. CANTHARIS VESICATORIA. (SPANISH FLY.) I object to the use of the blister, as a means of counter- irritation, and going further than this, I object to counter- irritation as a means of cure, when it can possibly be avoided, and I think it may be avoided in nearly all cases. As an internal remedy, Cantharis will have but one use- as a stimulant to the urinary apparatus, especially the blad- der. For this purpose it may be employed in small doses. CAPSICUM. (CAYENNE PEPPER.) Capsicum is a powerful topical stimulant; but its general influence is feeble. As Capsicum, it never gains admission to the circulation, and, in the process of digestion, it almost wholly loses its properties as a remedy. Capsicum is used as a topical stimulant to the skin, and with advantage where the circulation is feeble, and there is need of such stimulation. It also exerts the revulsive influ- ence of other rubefacients. 100 SPECIFIC MEDICINES. Its influence, when taken into the stomach, is of the same character. It excites the nerves, and calls an increased flow of blood to the part. In torpid states of the gastric mucous membrane, such action may be very desirable, may even be essential to life, as in congestive intermittent. It is the top- ical action upon the gastric mucous membrane that is bene- ficial in some cases of delirium tremens. The solar plexus, the most important of the vegetative nerve centers, may be thus influenced from the stomach. The stimulant influence of Capsicum may, therefore, be ex- tended through this, and be of marked advantage in states of great and sudden prostration with tendency to congestion. CARBO-LIGNI. (WOOD CHARCOAL.) Is an absorbent and antiseptic, and has this general use, both internally and topically. Given in water-brash, or where there is decomposition of the food, it is sometimes beneficial. So in topical disease with free secretion and tendency to sepsis-its local application absorbs the one and checks the other. The specific use of charcoal is to arrest hemorrhage from the bowels. It has been used in enema, 3ss. to 3j. finely pow- dered, to four ounces of water, thrown up the rectum. Why this checks it. I can not tell; that it does it, I have the evi- dence of my own eyes. For several years I have employed the second decimal trit- uration as a remedy in passive hemorrhage, with most marked benefit. I employ it in threatened hemorrhage during ty- phoid fever, in menorrhagia, especially when chronic, in pro- longed menstruation, the watery discharge that sometimes follows menstruation, hemorrhage from the kidneys, hemor- rhage from the lungs, and in some cases of leucocythemia. A good indication for this remedy is a small pallid tongue, with lenticular spots, and with this it may be given in any form of disease. The dose of the first or second trituration will be one grain, repeated as often as necessary. CARBOLIC ACID. 101 CARBOLIC ACID. We prepare Carbolic Acid for dispensing in general prac- tice by adding 3iv. of the crystals to 3xvj. of glycerine. In this form it is easily carried, and dispensed by adding the proper portion to water, so that the dose may be one tea- spoonful. Carbolic Acid exerts a specific influence in those cases in which, with a broad moist tongue, there is a cadaverous odor of the breath. It makes little difference what the name of the disease is-whether bilious or typhoid fever, cynanche, pneumonia, diarrhoea, dysentery, disease of the urinary ap- paratus, or whether the disease is acute or chronic. In these cases it is used in small doses as-R Solution of carbolic acid in glycerine, gtt. x. to gtt. xxx.; water, 3iv.; a teaspoonful every hour. We employ it with marked advantage in cases of irritable stomach, and to check nausea and vomiting, when the symp- toms above named present. The faintest trace of the odor of putrescent meat will be an indication. As far as my experience goes, it cannot be used with ad- vantage where the mouth is dry, or if the tongue is con- tracted, or enlongated and pointed. As a topical application, we employ carbolic acid when we need an antiseptic and a stimulant. Even here there must be the local symptoms, fullness and relaxation of tissues; when- ever there is contraction, shrinking and dryness, it will prove harmful. These rules hold good, whether as a dressing for wounds, for erysipelas, for burns, for a chancre, for a gargle, a vaginal injection, or for the treatment of a gonorrhoea or gleet. As a local application in full strength we use this agent to destroy warts, and epidermal growths of this character. It is very certain in its action, if thoroughly applied, and the cure is radical. It is also a remedy in epithelial cancer, and in some cases it will exert a better influence than the stronger escharotics. This is especially the case in cancer of the cer- vix uteri. In solution with glycerine it is applied to old in- 102 SPECIFIC MEDICINES. dolent ulcers, relieving pain, fœtor, and promoting normal granulation. The strength of the solution, in the treatment of cancers, will vary in different cases. In some the full strength of the solution in glycerine can be continually applied; in a few the full strength of the acid, rendered fluid by heat; but in others it will require dilution with glycerine. Use that strength that gives greatest ease, and leaves the parts in best condition. One of the principal objects is relief from pain, carbolic acid being a true anæsthetic in these cases, and the strength of the solution will be adapted to this use. CARDUUS BENEDICTUS. (BLESSED THISTLE.) Prepare a tincture from the fresh leaves and flowering tops, using alcohol of 98 per cent. It may be used in doses of from gtt. j. to x. as a stimulant and tonic, in cases of atony of stomach, liver and bowels. CASSIA ACUTIFOLIA. (SENNA.) Senna is a mild cathartic; but its action is frequently at- tended with much tormina, and to some is very unpleasant As it does not increase elimination by the bowels, its use as a cathartic is quite limited, and it may well be replaced by other remedies. It exerts, however, a special influence in colic, which ren- ders it an important remedy. We have generally employed it in the form of the Compound Powder of Jalap and Senna, in doses of five or ten grains, frequently repeated until re- lief is obtained. An infusion of senna-or the tincture will answer the same purpose-for the relief of colic, whether the common wind-colic or that known as bilious, I regard as one of our best remedies. CAULOPHYLLUM. 103 CASTANEA VESCA. (CHESTNUT.) A tincture is prepared from the fresh leaves in summer, using alcohol of 98 per cent. The dose will be from the frac- tion of a drop to ten drops. Chestnut leaves exert a specific influence in some cases of whooping cough, so much so, that the relief is apparent in twenty-four hours. They have usually been employed in in- fusion, but the tincture will be found as good, and is more easily dispensed. In convulsive cough or paroxysmal cough, resembling whooping cough, it has also proven a successful remedy. It may also be tried in cases where there is un- steadiness in the gait, and a disposition to turn to one side. CASTUS INDICUS. This remedy has been regarded as so valuable that it was monopolized by the government of Cashmere. A tincture is prepared from the root which is administered in doses of one drop; and is employed in giddiness, salivation, and as an antidote to poisonous bites and stings. CATALPA. (BEAN TREE.) Prepare a tincture from the recent seed and pods (beans), using alcohol of 98 per cent. Dose from the fraction of a drop to five drops. In small doses the tincture of Catalpa relieves irritation of the bronchial tubes, and gives freedom to respiration. It has been used in asthma with marked success, and is also recommended in chronic bronchitis, and in some forms of functional heart disease. CAULOPHYLLUM. (BLUE COHOSH.) We employ this remedy in infusion as a parturient, and in the form of a tincture of the recently dried root, 3viij. to alcohol 76 per cent Oj. 104 SPECIFIC MEDICINES. Caulophyllum exerts a very decided influence upon the parturient uterus, stimulating normal contraction, both be- fore and after delivery. Its first use, in this case, is to re- rieve false pains; its second, to effect co-ordination of the muscular contractions; and third, to increase the power of these. The first and the second are the most marked, yet the third is quite certain. Still if any one expects the marked influence of ergot, in violent and continued contractions, he will be disappointed. I judge that it exerts its influence through the hypogastric plexus; though to some extent it influences every process controlled by the sympathetic. Acting in this way it influ- ences the circulation, nutrition, and functions of the repro- ductive organs. I have employed it in chronic uterine dis- ease with advantage, especially where there is irritation, and uneasiness. It may be used with good effect in some cases of nervous disease; especially in that condition known as asthenic plethora. As a remedy for rheumatism it is inferior to the Macrotys, but in some cases it exerts a better influence. My experience has not been sufficient to point out these cases, and in this respect the remedy needs further study. CEANOTHUS. (RED ROOT.) Prepare a tincture from the recent leaves, using strong alcohol of 98 per cent. The dose will vary from the fraction of a drop to ten drops. The Ceanothus is a stimulant to the digestive apparatus, to the portal circulation, to the liver, and especially to the spleen. It is indicated by enlargement of spleen, sallow doughy skin, and expressionless face. A Southern physician reporting his experience with the remedy writes:-"In chronic cases, when the organ is no lon- ger tender, under the use of the tincture, even without fric- tion, it soon becomes painful and tender, then sinks rapidly to its normal size, and so remains, the patient no longer being conscious of its presence." CHAMOMILLA. 105 CERII OXALAS. (OXALATE OF CERIUM.) In doses of from one to three grains, this remedy has had quite a reputation in relieving the vomiting of pregnancy, though it has not proven so effective in vomiting from dis- ease of the stomach and adjacent organs. This would go to show that the remedy exerts a special influence upon the re- productive apparatus, and suggest that it might be used in some cases of uterine disease with good results. I have given it in the second decimal trituration with apparent success, in ulceration of the cervix, and in irritation with leucorrhoeal discharges. CELASTRUS SCANDENS. (FALSE BITTERSWEET.) This belongs to the class alterative. It has no special ac- tion that I am aware of, though it might be studied with ad- vantage. CHAMOMILLA (MATRICARIA.) (GERMAN CHAMOMILE.) A tincture is prepared from the recent flowers, with alco- hol 98 per cent. The dose will range from the fraction of a drop to ten drops. I employ it in the usual proportion of gtt. v. to gtt. x. in water 3iv., a teaspoonful every one or two hours. In infantile dyspepsia with irregularity of the bowels it will be found an excellent remedy, in diarrhoea with flatu- lence and colic, when the person is irritable and restless and the surface is alternately flushed and pale. CHAULMUGRA ODORATA. (CHAULMUGRA OIL.) In doses of from one to five drops internally, and as a local application, this oil may be used, in itching and burning pap- ulæ, psoriasis, chronic eczema, and in superficial neuralgia. 106 SPECIFIC MEDICINES. " It is especially beneficial when the affected parts have a fee- ble circulation, and common sensation is impaired. It has also been used in nasal catarrh. CHIRAYTA GENTIANA. (CHIRETTA.) A tincture is made from the imported plant, using alcohol of 98 per cent. The dose will vary from the fraction of a drop to ten drops. In India it is much employed in urinary disorders and un- easiness in lumbar region, frequent desire to pass urine, dif- ficult urination, and deposits of uric acid. It is also em- ployed in nervous and atonic dyspepsia, and in convales- cence from exhausting diseases. CHELONE GLABRA. (BALMONY.) The Chelone exerts an influence on waste and nutrition, and deserves study. We may prepare a tincture from the recent leaves, by expression, in the proportion of 3viij. to alcohol 76 per cent. Oj. Dose, ten to thirty drops. CHELIDONIUM MAJUS. (GREAT CELANDINE.) Among the remedies used by the school of Rademacher, Chelidonium held an important place. It was used for its specific influence upon the liver, though its action undoubt- edly extended to the entire chylopoietic viscera. It has also been employed by French and German physicians to a limi- ted extent, and is a remedy valued by Grauvogl, though not much used by the mass of Homœopaths. I have been experimenting with it for the past few years, and its action has been so satisfactory in some cases, that I am inclined to believe it will prove a valuable addition to our materia medica. I have used the German tincture thus far, in the proportion of gtt. x. to water 3iv., a teaspoonful every three or four hours. I propose, however, to have a tincture CHELIDONIUM. 107 prepared from our American plant as soon as possible, and test it; and I would recommend to any of my readers who know the plant—“Great Celandine, or Tetterwort”—to pre- pare a tincture from the fresh herb and root, and test it. on all the organs supplied In the olden time the liver I believe I can say that it acts from the solar plexus of nerves. was deemed the most important of these organs, and all dis- eases of the chylopoietic viscera were referred to it, hence the remedy was said to act specially upon the liver. The cases in which it has seemed to me to exert the greatest influence, presented the following symptoms: The tongue much enlarged, and somewhat pale; mucous membranes full and enfeebled; skin full and sallow, sometimes greenish; full- ness in hypochondria; tumid abdomen; light colored feces; no abdominal pain; urine pale but cloudy, and of high spe- cific gravity. I have seen cases of chronic disease presenting these symp- toms, with the addition of œdema of the feet and legs, in two of which the influence of the Chelidonium was seemingly direct and curative. In one, it is associated with other means, and a sufficient time has not yet elapsed to determine the suc- cess, yet thus far it is beneficial. In one case of enlarged spleen, with confirmed dyspepsia, the influence was marked from the first, and in three weeks the patient concluded to dispense with medicine, and let nature complete the cure (be- cause nature makes no charge for medicine.) I do not wish to introduce the Chelidonium as a remedy that has been thoroughly studied, though it has a record in this direction of nearly one hundred years. But from my experience I think it is one that may be tested with advan- tage. CHIONANTHUS VIRGINICA. (FRINGE-TREE.) Prepare a tincture from the bark of the root, recent or fresh, using strong alcohol of 98 per cent. The dose will vary from the fraction of a drop to ten drops. I have had very satis- 108 SPECIFIC MEDICINES. factory results from the usual prescription of gtt. x. to water Ziv., in doses of a teaspoonful. This remedy exerts a specific influence upon the liver, and to a slighter extent upon all the organs engaged in digestion and blood-making. The indication for it is, yellowness of skin and eyes, slight or fully developed jaundice, with a sense of uneasiness in right hypochondrium, or general abdominal pain simulating colic. It is one of the surest remedies I have ever employed, whether the case is one of jaundice, for- mation and passage of gall-stones, bilious colic (yellowness of skin), acute dyspepsia, acute or chronic inflammation of liver, or the irritable liver of the dipsomaniac. This agent comes to us with the recommendation of Dr. I. J. M. Goss, of Georgia, who says: "It possesses important alterative properties. As a cata- lytic, it has the most decided influence over the glandular system of any article I have tried. It pervades the whole system, combining with the materies morbi, and conveying it out of the system. I have used it in mercurial cachexy with the most happy success, in quite a number of instances. But the most important therapeutical property that it possesses, is its specific power over morbid conditions of the liver I have tried it in hypertrophy of that organ, and with uniform success; and also in obstruction of the liver, in malarious districts, with like success. Some years ago I called the at- tention of the profession to its specific effects in jaundice, and gave several cases in proof of the fact. Since then I have used the Chionanthus in a great many cases of jaundice, and have never failed to remove it in but one single case, and that one I think was a case of obstruction of the gall ducts by cal- culi; in that case, I tried all the reputed cholagogues, without success. It removes jaundice of years standing, in from eight to ten days. I have treated several persons that had been subject to jaundice, annually, in summer, for several years, and had been dosed with blue pill, calomel, and other arti- cles, without any benefit, and I have not failed in a single instance, to remove the disease entirely. And when it is re- CHLOROFORM. 109 lieved with the Chionanthus, it does not return; at least it has not, in any instance to my knowledge. It is as near a specific in jaundice, as quinine in periodicity. The mode in which I have used it is to make a tincture of the bark of the rootin gin, say 3ij. to the quart of gin, and give 3ss. of this every three hours, or the fluid extract, and give from one to two drachms every three hours." CHIMAPHILLA UMBELLATA. (PIPSISSEWA.) The Chimaphilla has been used mostly in infusion or de- coction: but for general use it may be prepared in the form of tincture, both of the recent and the dried leaves-though they will differ materially in strength and properties-the fresh leaves possessing a volatile principle which is lost in drying. The Chimaphilla has been principally employed as a tonic diuretic, influencing the urinary apparatus in a similar man- ner to the Buchu and Uva-Ursi, though I think it preferable to either. It relieves irritation of the entire urinary tract, and improves the circulation and nutrition of these organs. It also influences the processes of waste and nutrition, and possesses the properties termed alterative. In this respect it has not been thoroughly studied, though highly spoken of by some in the treatment of scrofula and secondary syphilis. CHLOROFORM. Chloroform by inhalation exerts a specific influence upon the brain, arresting its power to receive impressions-a con- dition known as anæsthesia. If carried still further, it in- fluences the spinal cord in the same manner, and arrests au- tomatic movement-respiration. This action is so well known, that it is not worth while occupying our space with it. Administered by mouth, in small doses, it is a cerebral stimulant; in large doses, it lessens consciousness, the effect being more like poisoning by alcohol, than the anesthetic in- fluence from its inhalation. 110 SPECIFIC MEDICINES. In small doses (gtt. v. to 3ss.) it is successfully employed to arrest convulsions. The small doses are safe, but it will not do to repeat it often in the larger quantity named. It is also used to relieve gastro-intestinal pains, especially in the form of common colic. In cases of biliary calculus it is used as a prophylactic, pre- venting the deposit of cholesterin, and causing its solution when deposited. For this purpose it is used in doses of gtt. xx., three times a day. CHLORAL HYDRATE. The introduction of this new remedy has been attended with the same enthusiasm displayed in the case of bromide of potassium. It is a hypnotic, and may be employed for this purpose, where there is an enfeebled condition of the brain, with im- paired nutrition. It relieves pain, when the nervous centers are suffering from impaired circulation, and may be advan- tageously employed in these cases. It has been successfully employed in the treatment of de- lirium tremens, but in some cases it has failed. I have used it for this purpose, with good results, sedation having been effected in sthenic cases, stimulation in asthenic. The remedy also suggests itself as one adapted to allay irri- tation and produce sleep in a majority of cases of puerperal mania. Dr. Playfair reports a case in which it was used with excellent success. I am satisfied from its action that it will prove a boon to the opium cater who desires to break off the destructive habit. Whilst its influence upon the nerve centers is the same as stimulant doses of opium, and will thus give present relief, it gives strength to the cerebral circulation, and will thus favor normal nutrition; then the dose can be lessened, and finally the remedy dispensed with. To give the estimate in which the drug is now held, I quote from the London Lancet : CHLORAL. 111 "This interesting drug has now been sufficiently tested by a large number of eminent practitioners to enable us to form a tolerably clear idea both of its merits and defects; and as we perceive that (after the usual fashion in matters medical) there is going to be an epidemic rage for the new remedy, it may be well to call the attention of the public to the princi- pal features of its action which can be said to be fairly made out. "In the first place, the term 'anaesthetic' should no longer be applied to chloral, for it has entirely failed to make good its claim to this reputation; even the largest doses do but produce a heavy and prolonged sleep, which is, however, es- sentially different from true anesthesia. On the other hand, as a producer of sleep, Chloral is, in many respects, unri- valed; for though, like every other remedy, it fails in a con- siderable number of cases, it does succeed in a very large number. In fact, it is inferior in certainty, as a hypnotic, to opium alone. Moreover, it is very greatly superior to opium, and almost every other drug, in the character of its sleep- producing action; there are no attendant symptoms of cere- bral oppression; the sleep, though often prolonged, is light and refreshing, and no unpleasant after-symptoms are expe- rienced. It is important to observe, however, that this de- scription only applies to the use of moderate quantities, and that not only unpleasant but highly dangerous symptoms have been produced by doses which we regret to see are very com- monly used. Very careful inquiry leads us to assert that it is both unnecessary and dangerous to give larger doses than twenty to thirty grains, repeated once or twice if necessary, for hypnotic purposes. Doubtless it might happen that 100 consecutive patients might take much larger doses with im- punity, but the 101st might present the alarming symptoms described by Dr. Reynolds, in a recent number of the Prac- titioner, as produced by a dose of fifty grains, and these symp- toms might easily take a fatal turn. "As a remedy for pain, Chloral holds a very varying place in the estimation of medical men, some rating it highly, and 112 SPECIFIC MEDICINES. others thinking it almost worthless. Perhaps the safest esti- mate of its power over pain is that it only exerts an indirect influence by inducing a disposition to sleep, in which the pain is forgotten. Certainly it has entirely failed, in the hands of the present writer, to relieve severe pain of a pure neuralgic type. On the other hand, there is a good deal of evidence that it relieves suffering where the parts are very tense, and where mere arterial throbbing counts for much in the produc- tion of pain; thus it has been very favorably spoken of for its effects in gout. And this fact, if it be correct, corres- ponds with certain observations which have been made as to its action on the circulation. Both from sphygmographic ex- periments on healthy persons and on patients, and also from the details of the nearly fatal case reported by Dr. Reynolds, there is reason to think that Chloral exerts a contracting in- fluence upon the arteries, powerful in proportion to the dose; and it may well be that arterial throbbing is checked by this kind of influence. "On the whole, however, there can be little doubt that the great function of Chloral is that of a hypnotic and calmer of general nervous irritability. In delirium tremens it is excel- lent: and it is probable that with two such weapons for choice as bromide of potassium and chloral we shall be able almost entirely to dispense with the use of opium, which is so un- certain and dangerous a remedy in that disease In the state of sleeplessness which threatens the access of puerperal mania, chloral is probably an unequaled remedy. In melan- cholia its action as a hypnotic appears to be powerfully and remarkably sure. In mania, also, it acts well enough as a hypnotic, though there seems some divison of opinion as to whether it does permanent good. We may also state that in the irritable condition of aged persons who find it difficult to sleep for any length of time continuously, the use of a sin- gle dose of thirty grains of chloral appears often to answer excellently well. The minor uses of the drug in relieving more trivial conditions of nervous irritation, and in allevia- ting painful spasmodic symptoms of various kinds, are pro bably considerable." CINNAMON, 118 CIMICIFUGA. (See Macrotys.) CINCHONA. (See Quinia.) CISTUS CANADENSIS. (ROCK-ROSE.) Preparation.-A tincture is prepared from the recent plant, in the proportion of 3viij. to alcohol 76 per cent. Oj. The dose is from ten to thirty drops. The Cistus has a direct and positive influence on the pro- cesses of waste and nutrition, and hence possesses the pro- perties known as alterative. It has been used with especial advantage in scrofula, and in chronic diseases dependent upon an enfeebled nutrition, or deposit of imperfectly formed plasma. It is also reported to have a specific influence upon the intestinal canal, curing chronic diarrhoea and dysentery. It deserves a thorough investigation, which I trust some of our practitioners will give it. CINNAMON. Preparation. We prepare a tincture from the oil, in the proportion of 3j. to alcohol 98 per cent. viij. Dose five to thirty drops. Cinnamon thus prepared exerts a direct influence upon the uterus, causing contraction of its muscular fibre, and ar- resting hemorrhage. To a limited extent, it exerts an influ- ence on the entire circulatory system, checking hemorrhage from any part. It is one of the most certain remedies we have for uterine hemorrhage, either during parturition or at the menstrual period. I have used it since I commenced practice, and have never failed to arrest post-partum hemorrhage with it, though I have had some very severe cases. 10 114 SPECIFIC MEDICINES. CITRUS LIMONIS. (LEMON.) The expressed juice of the lemon is a specific in certain cases of rheumatism-the tongue being red, and elongated, and the inflamed part showing an unusual bright redness. It is also of advantage in other inflammatory diseases, and in fevers with similar symptoms. In such cases patients have lemon juice or lemonade to the extent they may have a desire for it. It also exerts a marked influence when locally applied, in hypertrophy of the tonsils, and elongated uvula. CLEMATIS VIRGINIANA. (VIRGIN'S BOWER.) This agent has not been studied, though it deserves inves- tigation. Prepare a tincture from the recent leaves, in the proportion of 3 viij. to alcohol 76 per cent. Oj., using pressure. Dose, gtt. v. to gtt. x., to determine its influence upon the nervous system and upon the secretions. COFFEE. (Java or Rio.) Take of the berries of Coffee, ground (not roasted) 3 viij., alcohol 76 per cent. Oj. Make a tincture by percolation. Dose, gtt. ij. to gtt. x. Coffee is a stimulant to the cerebral nervous system, and may be employed in many cases where there is atony, with disordered function. Were it not for the general use of cof- fee as a beverage, it would prove a valuable remedy; but when persons are habituated to its use, it exerts but little in- fluence. COLCHICUM. It is difficult to procure a reliable preparation of Colchi- cum, and we have been obliged to use the English wine of Colchicum. Our manufacturers in this city now prepare a COLOCYNTH. 115 tincture, representing ounce for ounce of the crude article. The medium dose is one drop; we do not desire a cathartic action. Colchicum has long been used as a remedy for rheumatism and gout; and, though probably the best of the old materia medica, it failed of giving its best results because used in poi- sonous doses. In acute and chronic rheumatism it should be employed in small doses, following or alternated with the seda- tives. We only obtain its anti-rheumatic influence when the pulse and temperature are reduced to nearly a normal stan- dard. It is also beneficial in some cases of intestinal disturbance, especially when there is gaseous accumulation. Thus in colic from intestinal irritation, it may be employed in the proportion of gtt. xx. to water ziv., a teaspoonful every two hours, with prospect of success. It exerts an influence upon the skin, and may occasionally be employed with advantage in chronic disease of the surface. Dr. L. A. Kelley writes me in reference to the specific indications for Colchicum :-"The pain for Colchicum, so far as my experience goes, is, sharp-shooting, tearing or dull. aching, extending from the back to hip, and down the limb, without fever. It is not the kind of pain so much as its posi- tion; hence it is of value in certain forms of chronic or sub- acute sciatica. Whenever I have used it in such cases for pain in that region, its use has been attended with good results." COLOCYNTH. Colocynth has been employed as a cathartic, but for this purpose it is harsh and uncertain, and may well be dispensed with. I use it wholly as a remedy for dysentery and in colic. And for this purpose employ the tincture in small doses, usually gtt. v. to water 3iv. A teaspoonful every hour will give the best results. 116.. SPECIFIC MEDICINES. It will also prove beneficial in some cases of diarrhoea at- tended with tormina and tenesmus. I am satisfied that a thorough investigation of the remedy in small doses, will de- velop other important uses. COLLINSONIA CANADENSIS. (STONE ROOT.) We employ a tincture of the Collinsonia, respresenting the crude article ounce for ounce. As there are a great many imperfect preparations in the market, I would advise that it be procured from one of our own houses in this city. Collinsonia is a specific in ministers' sore throat; adminis- tered in the proportion of: R Tincture of Collinsonia, simple syrup, aa., half teaspoonful to a teaspoonful four times a day. It proves beneficial in other cases of chronic laryngitis, in chronic bronchitis, and phthisis, allaying irritation, and checking cough. It also exerts a favorable influence upon the digestive pro- cesses, improving the appetite, facilitating digestion and act- ing as a general tonic. It passes off through the kidneys, and exerts a tonic influ- ence upon the entire extent of the urinary tract. I have thought that its influence was specially exerted upon and through the pneumogastric, relieving irritation of, and giving strength to parts supplied from this source. Collinsonia is a specific in the early states of hemorrhoids, and will sometimes effect a cure in the advanced stages of the disease. In this case it is employed in small doses: R Tincture of Collinsonia, gtt. x.; water, Ziv.; a teaspoonful four times a day. I have given the therapeutics of. Collinsonia thus briefly, that the points named might make the greater impression upon the reader. I regard it as one of the most direct and valuable agents of the materia medica, and one that will give satisfaction to whoever employs it. COMPTONIA. 117 COCA. (LEAVES OF THE ERYTHROXYLON COCA.) Coca is a stimulant to the nerve centers, and at the same time diminishes waste. It allays hunger, and enables the person to endure great fatigue. The excretions are all di- minished whilst the person is under its influence. It may prove useful in the early stages of tuberculosis, by enabling the person to take the exercise so much needed to burn the imperfect materials in the blood. The dose of the crude leaves is from five to ten grains, but it is better em- ployed in infusion. COTO BARK. (AN UNKNOWN SPECIES OF NECTANDRA.) Coto Bark is imported from Bolivia, and though its source is unknown it is thought to be a species of Nectandra. It is one of the "new preparations" extensively advertised. A tincture is prepared from it in the usual way, of which the dose is from the fraction of a drop to ten drops. It has proved a valuable remedy in profuse sweating and in atonic diarrhoea. In the colliquative perspiration of phthisis, it is thought to give better results than the reme- dies ordinarily employed. It is also reported to have given good results in cholera infantum. COMPTONIA ASPLENIFOLIA. (SWEET FERN.) Prepare a tincture from the recent leaves, using alcohol 76 per cent. The dose will range from one drop to 3ss. It may be employed in diarrhoea with colic, and in dysen- tery when the febrile symptoms are relieved. It has also been used as a local application in rheumatism. 118 SPECIFIC MEDICINES. CONVALLARIA MAJALIS. (LILY OF THE Valley.) Make a tincture of the recent plant entire, root and flow- ers, using alcohol of 98 per cent; or a tincture may be made of the flowering plant, and at maturity of the rhizome. The dose will vary from the fraction of a drop to ten drops. It may be used to lessen the frequency of the pulse, when there is an impaired capillary circulation, as shown by ecchy- mosis, or the slow return of blood when it is effaced by the finger. The tincture of the root has had some reputation in the treatment of rheumatism and dropsy, and to improve the digestive functions. CONVALLARIA MULTIFLORA (SOLOMON'S SEAL.) Prepare a tincture from the recent root, using alcohol of 76 per cent., or administered in substance or infusion. The dose will vary from a dilution to as much as a half drachm There is no doubt that this remedy exerts a special action upon the circulation, especially the veins. It relieves con- gestion of the liver, spleen, and intestine, promotes a better circulation in the portal system, and relieves and sometimes cures hemorrhoids. It has also been used in the treatment of rheumatism. As a local application it has been used in bruises and ecchymosis, in acute and chronic conjunctivitis, in hemor- rhoids, and to varicose ulcers. CROCUS SATIVUS. (SAFFRON.) A tincture prepared from the fresh true saffron will be found an excellent remedy in the treatment of diseases of children, especially in the eruptive fevers, or when there has been a retrocession of the exanthemata. It may be given with Aconite or alone, adding gtt. x. to xx. in water Ziv., a teaspoonful every hour. CUBEBA. 119 CROTON TIGLIUM. (OLEUM TIGLII.) A tinctur is prepared by adding 3j. of the oil to alcohol 98 per cent. Oj., which may then be filtered through paper Add gtt. s, to water 3iv., and give in teaspoontul doses. It may be given in cardialgia, in hepatic colic, in diarrhoea with tonesmus, and in dysentery if the patient is free from fever. It is also employed in chronic diseases of the skin, especially those which are pustular, and when the surface burns and itches on getting warm in bed and from active exercise. CUBEBA. Administered in substance in doses of five to twenty grains, it exerts a direct influence upon the bladder and urethra, and will sometimes cure an old gonorrhoea or gleet when other remedies fail. It has also been used in the scalding of urine in women, and burning and irritation of the vulva. It will be found useful in some cases of cystitis, the more acute symptoms having passed away. The tincture prepared in the usual way, with alcohol of 98 per cent. may be used in minute doses, or in doses of from gtt. x. to 3ss. In the small dose it may be used in debility with irritation of the reproductive apparatus, prostatorrhoea, uneasiness and formication of scrotum and anus, and dis- eases associated with reproductive weakness. CUCUMIS SATIVUS. (CUCUMBER.) Grate the green cucumber until a sufficient quantity is ob- tained, and add it to alcohol of 98 per cent. in the propor- tion of 3viij. to Oj. ; let it stand six days and filter. This tincture may be given in irritation of the urinary pas- sages, sharp pains in the loins, and in rheumatic pains of the shoulders. 120 SPECIFIC MEDICINES. CUPRUM. (COPPER.) For some years I have prescribed Copper in the pleasant form of greened pickles, with most marked advantage in some cases of chronic disease. Even yet I prefer to give Copper in this form, rather than as a medicine, but probably this is owing to prejudice. The cases where I have found it especially beneficial, were those in which with anæmia there was not very great loss of flesh. The surface would be pallid, or sometimes tawny, the skin waxy, parts usually colored with blood pale, with some- times a slight greenish tinge. The tongue broad, pallid, but usually clean; bowels torpid. The pulse rather full, but with- out sharpness of stroke. It makes no difference what the disease is, if these symp- toms should present I would think of Copper as a remedy. Rademacher employed Copper in the treatment of acute diseases, and claimed that there were seasons when the en- demic constitution of disease demanded it. The symptoms calling for it were :-"The color of the face was mostly palish- gray, dirty light blue, seldom reddish, and only a few times, in evening exacerbations, was it bright red and hot. The palate was always red. The sweats were moderate, some- times clammy, and often smelt very sour, and patients felt worse after them. In most cases there was a tendency to diarrhoea, or there was more or less of diarrhoea present. In pneumonia, patients complained of a sense of pressure. under the sternum and of weight in the chest; though some- times there would be no complaint, until a sense of suffoca- tion announced extensive infiltration of the lung." Grauvogl accounts for the action of Copper in this way: "Science has already demonstrated that Copper, in a finely divided state, absorbs immense quantities of ozone. It is also demonstrated that the ozone in the atmosphere is not found in the usual quantity in places, for example, which are affected by cholera, or, in which the atmospheric electricity is negative. Now Copper is one of the chief prophylactics CURCAS. 121 against cholera, as we learn from workers in Copper, who re- main free from cholera. Copper cures this disease in its first appearance, and in every case, so long as the consequences of the first stage have not set in, which naturally can no longer yield to the influence of Copper." Speaking of water charged with a compound of cyanogen called iodosmone, he remarks: "Moreover if one smells too often of this water, or drinks even a small quantity thereof, he will experience in himself all the phenomena which precede cholera, followed by violent cholerine. The surest remedy to arrest, almost in a moment, this artificially produced state, is water impregnated with ozone. I convinced myself personally of the truth of this discovery. If we add to this the property of Copper in a finely divided state, of absorbing great quantities of oxygen, then the operation of Copper is explained according to a nat- ural law; it operates inwardly, administered in a finely divi- ded state, as a function remedy, as an ozone-bearer, since, circulating with the blood. it takes up more ozone from the inspired air than does the blood, and imparts it to the blood. Accordingly, all disease-forms, in which Copper is the remedy, are to be referred to a lack of ozone, or an overplus of iodos- mone in the blood, and these disease-forms naturally consti- tute as comprehensive a group as the atmosphere forms a comprehensive condition of life." CURCAS (JATROPHA.) (PHYSIC NUT.) The nuts are the product of a West India shrub, and the expressed oil has been used in doses of ten or fifteen drops as a cathartic. If the germ is removed from the seeds the action is quite mild, but the embryo is intensely irritant to the stomach and intestinal canal. It has some of the pro- perties of Croton Oil (though much milder) and has been used as an external application. 122 SPECIFIC MEDICINES. CYCLAMEN. A tincture is prepared from the root (tuber) in the early spring, or during the rest of the plant. In this country the tincture will be prepared from the tuber's of hot house plants. Add gtt. j. to v. to water 3iv., and give a teaspoonful as a dose. It may be given to arrest severe vomiting, especially from cerebral disease, in dizziness, tendency to syncope, inability to walk strait, and in diarrhoea accompanied by tormina and tenesmus. CYDONIUM. (QUINCE SEED.) In addition to the common use of a mucilage of quince seed in sore throat, sore mouth, chapped nipples, and conjuncti- vitis, it has been recommended to discuss slow inflammatory deposits, tumors, and to cure cancer (?). The remedy is prepared in the following way: take quince seed ŝiv., alcohol 3viij.; macerate for twenty days and ex- press. This is mixed with an equal part of turpentine, and the tumors are thoroughly rubbed twice a day. CYPRIPEDIUM PUBESCENS. (LADY'S SLIPPER.) Preparation.-Prepare a tincture from the recent root, in the proportion of 3viij. to alcohol 76 per cent. Oj. The dose will range from gtt. ij. to 3j. The Cypripedium is a nerve stimulant, improving the cir- culation and nutrition of the nerve centers. Hence it proves useful in sleeplessness, nervous irritability from atony, in neuralgia, delirium, and other disturbances from the same cause. It is a feeble agent, and too much must not be expected of it. It is a stimulant, and will only be applicable in ner- vous atony. DELPHINIUM. 123 Its best use will doubtless be found in children, to soothe irritation of the nervous system. I make the following pre- scription which is an admirable "Soothing Syrup:"-R Tinct. of Cypridedium, comp. tinct. of lavender, aa. 3ij., tinct. of lobelia, 3j. simple syrup, 3iiiss. M. DAMIANA. (LEAVES OF THE TURNERA APHRODISIACA.) The leaves of this plant were introduced from Mexico as a certain and permanent aphrodisiac, but before the agent could be thoroughly tested the market was flooded with a spurious article (a very common practice) so that to day, out of twenty specimens, nineteen would be fictitious. This is especially the case with extracts and fluid extracts. The true Damiana is tonic and slightly laxative, and un- doubtedly increases the sexual appetite, and the power of the reproductive organs. Yet we do not believe it will grow new testes, when they have become atrophied (?) . DAPHNE INDICA. A tincture is prepared from the bark of the branches, using alcohol of 98 per cent. The dose should be very small, one drop to water 3iv. or a dilution. The patient has prostatic discharges, a lax and pendulous scrotum, despondency, and nocturnal emissions. DELPHINIUM STAPHISAGRIA. (STAVESACRE.) Preparation.-A tincture is prepared from the ground seed, (it having been pressed between bibulous paper to remove the fixed oil), in the proportion of Zviij. to alcohol 98 per ct. Oj. The tincture of Staphisagria has a specific action upon the reproductive organs of both male and female; but more marked in the first. It quiets irritation of the testes, and strengthens their function; it lessens irritation of the pros- tate and vesicula; arrests prostatorrhoea, and cures inflam- 124 SPECIFIC MEDICINES. mation of these parts. It also exerts a marked influence upon the urethra, quieting irritation and checking mucous, or muco-purulent discharges; it influences the bladder and kidneys, but in less degree. The action of Staphisagria upon the nervous system is pe- culiar. It exerts a favorable influence where there is depres- sion of spirits and despondence, in cases of hypochondriasis and hysteria, especially when attended with moroseness, and violent outbursts of passion. I employ it in the proportion of: R Tincture of Staphisa- gria, 3j.; water, 3iv. A teaspoonful every four hours. The seed of the Delphinium Consolida, or Larkspur, pos- sesses similar medical properties, but is not so active; a tinc- ture may be prepared in the same way, and used in the same dose. DIERVILLA CANADENSIS. (BUSH HONEYSUCKLE.) Preparation.-A tincture may be prepared from the recent leaves and twigs, 3 viij. to alcohol 76 per cent. Oj. Dose gtt. x. to 3j. We have no positive knowledge with regard to this agent, though it is credited with active properties. It would be well to test its influence upon the urinary apparatus, and to increase waste and nutrition. DIGITALIS PURPUREA. (FOXGLOVE.) Prepare a tincture from the recent dried leaves in the pro- portion of 3 viij. to alcohol 76 per cent Oj. Dose, from the fraction of a drop to five drops.-R Tincture of Digitalis, gtt. x. to xx.; water, 3iv. A teaspoonful every one or two hours. Digitalis may be employed for the general purposes of a sedative, to lessen the frequency of the pulse, and the tem- perature, in cases of fever and inflammation. It is somewhat analogous to aconite, and exerts the best influence in atonic conditions. For these purposes, however, it must be used in small doses. 1 DROSERA. 125 It is a powerful cardiac tonic when used in small doses, and may be employed in any case of heart disease where the or- gan is enfeebled. It not only gives the necessary stimulation for the present, but it gives a permanent improvement; doubtless through an improved nutrition. It exerts an influence upon the capillary circulation, and may be employed with much certainty to arrest asthenic hemorrhages. It also influences the absorption of dropsical deposits, and increases secretion from the kidneys, probably in the same way. There is no cumulative effect when Digitalis is used in small doses. DIOSCOREA VILLOSA. (WILD YAM.) An infusion of the recent Dioscorea will undoubtedly give the best results. A tincture may be prepared from the re- cent root in the proportion of 3 viij. to alcohol 76 per cent. Oj. Dose gtt. j. to 3j. The article that has been sold for Dioscorea by some drug- gists for the past ten years, and from which the Dioscorein has been prepared, is a species of smilax. A very good joke on Dioscorein! but unpleasant to those who have expected it to relieve pain in the bowels. True Dioscorea, when recent, is a specific in bilious colic, when given in infusion, or even in tincture. In any case it allays gastro-intestinal irritation, and favorably influences the vegetative processes. It is a feeble but certain diaphoretic, and allays irritation of the nervous system. DROSERA ROTUNDIFOLIA, (SUNDEW.) We employ a tincture of the fresh plant prepared in Ger- many, using it in the proportion of: R Tincture of Drosera, gtt. x. to 3j.; water, 3iv. A teaspoonful every three or four hours. - 126 SPECIFIC MEDICINES. I use the Drosera as a specific in the cough attending and following measles, especially where there is dryness of the respiratory mucous membranes. An experience of twenty years with it, in a large number of cases, has given me great confidence in the remedy. We also use it in cases of whooping cough, especially where there is dryness of the air-passages, and much irritation of the nervous system. Whilst it is not a remedy for all cases of whooping cough, it is a true specific in those to which it is adapted. I have often seen a serious case of the disease relieved in twenty-four hours, and an entire arrest of the cough in two weeks. We also employ it in cases of chronic cough, with dryness of the air-passages and nervous irritation, with much advan- tage. It makes little difference whether it arises from bron- chial irritation or inflammation or phthisis, if associated with irritation of the basilar portions of the brain and pneumo- gastric. DUBOISIA MYOPŒOIDES. The leaves of the Duboisia are the product of a tree-like shrub growing in Australia, but from their varying strength it has been thought best to employ the alkaloid duboisina, which may be solved in water and given in doses of one-six- tieth to one-thirtieth of a grain, by mouth or hypodermic in- jection. In action the Duboisina very clearly resembles atropia, the alkaloid of belladonna, for which it may be used in the same cases. It dilates the pupil quite as readily as atropia, but its effects pass off sooner, and it does not interfere so long with the accommodation of the eye. It arrests profuse per- spiration, stimulates the capillary circulation, but lessens the frequency of the pulse, and is not a cerebral stimulant. We purpose having a tincture made from the recent Du- boisia, and hope to find it a good remedy. 1 EPILOBIUM. 127 ELATERIUM. Elaterium is a deposit from the juice of the squirting cu- cumber, and if fresh is in small flat fragments of a pale greyish color. For use we make a tincture, adding 3j. to alcohol of 98 per cent. Oj., macerating for one week and fil- tering; of this the dose will vary from the fraction of a drop to a half a drachm. Prof. King recommended this remedy in chronic cystitis, and it has been used in a large number of cases with the most flattering results. He directed that half a drachm be ad- ministered three times a day until it purged freely, and then that it be given in doses of five drops three times a day un- til the disease was subdued. Even in doses much smaller than this, it will be found to exert a curative influence upon chronic nephritis and cystitis. In cathartic doses Elaterium has been a prominent remedy in the treatment of dropsy, and even in very small doses it will sometimes cure this disease, and I have alternated it with apocynum. EPIGEA REPENS. (TRAILING ARBUTUS.) This remedy deserves further and careful investigation. We wish to determine its influence upon the urinary appa- ratus, and the intestinal canal. For this purpose a tincture of the fresh leaves may be prepared with dilute alcohol, EPILOBIUM PALUSTRE. For general use the infusion is the preferable form for ad- ministration; but we have a tincture prepared with dilute alcohol, employing pressure. The Epilobium exerts a specific influence upon the intes- tinal mucous membrane, relieving irritation, and promoting normal function. Thus, it is employed in acute diarrhoea and dysentery, and in colic, with advantage. I have also pre- 128 SPECIFIC MEDICINES. scribed it to quiet the irritation and check the diarrhoea in typhoid fever, with marked benefit. It is especially valuable, however, in chronic diarrhoea and dysentery; sometimes effecting cures where all other means had failed. Thus, I employed it extensively in the treatment of the chronic diarrhoea during the recent war, and with a success not to be obtained from other remedies. I do not pretend to account for its action, but its curative influence is well established. ERECHTHITES HIERACIFOLIUS. (FIREWEED.) Preparation.-A tincture may be prepared from the recent plant, in the usual proportions, using alcohol of 76 per cent. Dose, from gtt. j. to 3ss. We have here another remedy that requires study. It in- fluences mucous tissue, especially of the bowels and lungs, and this will be the direction of the investigation. ERGOTA. The fresh Ergot may be used in powder, infusion, or a tincture may be prepared in the usual way, with alcohol of 76 per cent. To strengthen the pains in labor, I should pre- fer this remedy in infusion, but for medicinal use I prefer the tincture. In tedious labors, when the os is dilated, and the soft parts dilatable, and the pains grow weaker, the patient showing evidences of exhaustion, Ergot may be given in the usual doses. I rarely use it in my practice for this purpose. In passive hemorrhage with a feeble circulation of blood, tincture of Ergot may be given in doses of five to ten drops, until the flow of blood is arrested. In dizziness, partial loss of consciousness, unsteadiness in the legs, with dull eyes and dilated or immobile pupil, Ergot becomes a prominent remedy. So also in threatened apoplexy, in the coma that follows apo- plexy, and in epilepsy followed by marked congestion of the ERYNGIUM. 129 brain, I give this remedy. In many cases it may be used in the common way :-R Tincture of Ergot, gtt. x., water 3iv., a teaspoonful every two or three hours. ERIGERON CANADENSE. (CANADA FLEABANE.) We employ the Oil of Erigeron in practice, for the arrest of hemorrhage. For passive hemorrhage it is one of the most valuable remedies we have, and may be relied upon in hem- orrhage from any organ or part. For this purpose the dose will be from five to ten drops on sugar, as often as may seem necessary. The Erigeron influences the kidneys in a manner similar to Buchu. It may be employed in diabetes and albuminuria with advantage; also, in chronic inflammation of the kidneys, bladder and urethra. Latterly is has been recommended for gonorrhoea. ERYODYCTION GLUTINOSUM. (YERBA SANTA.) A tincture is prepared from the recent dried leaves in the usual way, with alcohol of 98 per cent. It is dispensed with glycerine and syrup, the dose being from gtt. j. to gtt. x. The Yerba Santa is a stimulant to the respiratory mucous membranes, and for this purpose it may be employed in pha- ryngitis, laryngitis, and bronchitis. It also exerts a favora- ble influence in catarrhal gastritis. ERYNGIUM AQUATICUM. (WATER ERYNGO.) The Eryngium may be employed in infusion, or in the form of a tincture of the recent dried root, 3 viij. to proof spirit, Oj. Dose gtt. j. to gtt. xx. The Eryngium exerts a specific influence upon the bladder and urethra, relieving irritation. It is one of the most cer- tain remedies that can be employed in dysuria from irritation, 130 SPECIFIC MEDICINES. and in spasmodic stricture; continued, it proves curative in these cases. It has been employed for other purposes, and we find it highly recommended. It undoubtedly deserves a thorough investigation. ERYTHROPHLŒUM. (SASSY BARK.) Sassy bark is imported from West Africa where it is em- ployed by the natives as an ordeal poison, and it also enters in the composition of the fetich of the obi men. It contains an alkaloid, erythrophleina, which is intensely poisonous. Given in large quantity in the ordeal it produces giddiness, and inability to cordinate the voluntary muscles, and it may produce emesis by which it is ejected from the stomach. If it produces emesis the patient may live, if not he dies from paralysis of the respiratory apparatus and heart. In minute doses (of a tincture one drop to water Ziv.) it may be given to stimulate the capillary circulation, to in- crease secretion of urine, arrested by feeble circulation, and to check atonic diarrhoea. ETHER. (SULPHURIC ETHER.) As an anesthetic Ether is now preferred by many to chlo- roform, as it is thought there is very much less danger in its use, and especially if given by persons not familiar with the administration of anæsthetics. It is inhaled from the cup- ped napkin, as we administer chloroform, care being used to admit a sufficient amount of air. In doses of two to ten drops on sugar it is a stimulant to the brain and spinal cord, and will relieve nervous headache, palpitation and irregular action of the heart, imperfect res- piration, etc.; the face being cool and pallid, and the pulse feeble. : EUPATORIUM. 181 EUCALYPTUS. A tincture is prepared from the leaves, using alcohol 98 per cent. The dose will vary from the fraction of a drop to fifteen drops. It exerts a gently stimulant influence upon the nerve cen- ters, improves the circulation and respiratory function, and opposes the influence of malaria in the blood. It is a feeble antiperiodic but will sometimes arrest an ague; when an ague is broken, it is a very good remedy to perfect a cure. It is also a fair means of prophylaxis, though not so good as the small doses of quinine. It has been employed in bronchitis with fetid expectoration, dilatation of bronchia, and in some cases of asthma. It needs further study, for if it ever be- comes a remedy of first importance, it will be in the very small dose, and as yet we have not the indications for it. EUONYMUS ATROPURPUREUS. (WAHOO.) Preparation.-Prepare a tincture from the bark of the recent root, in the proportion of 3viij. to alcohol 76 per cent. Oj. Dose, gtt. j. to 3ss. The Euonymus stimulates the nutritive processes, and in some cases improves digestion. Usually, however, it will need to be combined with a pure bitter, as Hydrastis, to get its full action in this direction. It exerts a marked influence in malarial diseases, and de- serves the name of antiperiodie, though it is much feebler than quinine. It may, however, be used in these cases with marked advantage, after the fever has been once broken. EUPATORIUM AROMATICUM. (WHITE SNAKEROOT.) Preparation. Prepare a tincture from the recent dried root in the proportion of 3viij. to alcohol 76 per cent. Oj. Dose, gtt. j. to gtt. xx. 132 SPECIFIC MEDICINES. This variety of the Eupatorium exerts a marked influence upon the brain, relieving irritation and promoting normal action. It is also diaphoretic, and probably influences, to a slight degree, all of the functions governed by the sympa- thetic. It will repay careful investigation. EUPATORIUM TEUCRIFOLIUM. (WILD HOARHOUND.) Preparation,—Prepare a tincture from the recent plant, using dilute alcohol. The dose will vary from one to twenty drops. In small doses it stimulates all the functions controlled by the sympathetic nervous system; improving digestion, blood making, and stimulates waste and excretion. It may be com bined with a simple bitter tonic, or preparation of iron, or the hypophosphites, for its restorative influence, or with the vegetable alteratives for its other use. In large doses it is a powerful diaphoretic. EUPATORIUM PERFOLIATUM. (BONESET.) Preparation.-Prepare a tincture from the recently dried herb in the proportion of 3viij. to proof spirit Oj. Dose, from the fraction of a drop to ten drops. The Eupatorium increases functional activity of the skin, and to a less extent, secretion from the kidneys. It also in- fluences the circulation, to a slight extent, and does well, combined with the sedatives. In quite small doses it stimulates the sympathetic nervous system, and improves all the vegetative functions. It is not an active remedy, and too much must not be expected of it; yet, in many cases, it may well supplant costly foreign drugs. The best indication for Eupatorium is a frequent, full pulse, flushed skin, inclined to be moist. Throbbing pain is the local indication. EUPATORIUM. 133 EUPATORIUM PURPUREUM. (QUEEN OF THE MEADOW.) Preparation.-Prepare a tincture from the recent root, in the proportion of Zviij. to alcohol 98 per cent Oj. Dose, gtt. j. to gtt. x. Its principal influence is upon the kidneys, and it may be employed whenever an increased volume of urine is de- sirable. It has been mostly employed in the treatment of dropsy, with reported success. Its influence upon the urinary organs may doubtless be made valuable, but it requires further study. EUGENIA JAMBOLLINA. The A tincture is prepared from the seeds, and from the bark, (imported from India), using alcohol of 98 per cent. dose will vary from the fraction of a drop to ten drops. It is indicated by giddiness with abdominal pain, colic, pains in the back and loins, and is thought to be beneficial in hernia and illeus. EUPHORBIA HYPERICIFOLIA, A tincture is prepared from the recent root, using alcohol of 98 per cent. The dose will vary from the fraction of a drop to five drops. I generally administer it in the usual proportion of gtt. x. to water 3iv., the dose a teaspoonful. This is one of the most certain remedies employed in cholera infantum, in some cases being much better than ipe- cac. It is also an efficient remedy in mucous enteritis, irri- tant diarrrhoea, inflammation of the cœcum, and dysentery. It is usually administered with aconite. It is also likely to prove a most efficient remedy in pneumonitis and bronchitis, especially of children. 134 SPECIFIC MEDICINES. EUPHORBIUM. The Euphorbium is an extremely acrid resin, and has been used for the purpose of counter-irritation. Added to the irri- tating plaster of our dispensatory it renders it much more active, or a very small portion may be dusted on an ordinary strengthening plaster, giving it the activity of an irritating plaster. A tincture may be prepared in the usual way, with alcohol of 98 per cent, which is then used in the second or third de- cimal dilution. In the very small dose, this remedy may be employed in gastric catarrh, in atonic diarrhoea, in asthenic bronchitis, and in abdominal dropsy from asthenia. EUPHRASIA OFFICINALIS. (EYEBRIGHT.) In infusion or a poultice this herb has been employed with good results in conjunctivitis. For general use prepare a tincture from the fresh plant, with alcohol of 98 per cent. The dose will range from the fraction of a drop to ten drops. In small doses it will be found to exert a beneficial influ- ence in conjunctivitis, and even in chronic disease of the eye itself. It is also a good remedy in catarrhal disease of mu- cous membranes, both of the respiratory apparatus, and intes- tinal canal. It may also be thought of in disease of the ear, especially when associated with disease of the throat. EUPHORBIA COROLLATA.-E. IPECACUANHA. (BOWMAN'S ROOT-WILD IPECAC.) Preparation.--Prepare a tincture of the first from the bark of the root, of the second from the root (dried), 3viij. to alcohol 76 per cent. Oj. Dose, gtt. j. to x. These remedies have not been sufficiently studied ; yet, pos- sessing active properties, they are likely to prove valuable. The Euphorbia Corollata exercises a direct influence upon the mucous surfaces, relieving irritation, and promoting func- tional activity. This is noticed more especially upon the diges- FERRUM. 135 tive tract. In quite small doses it improves digestion, both stomachic and intestinal, and tends to overcome constipation and irregularity of the bowels. It may be employed with advantage in some forms of diar- rhoea and dysentery, using it in 'the place of Ipecac. To arrest inflammatory action in the intestinal canal, seems to be its specific use. FAGONIA ARABICA. An Indian plant recommended by Dr. Honingberger, who gave the herb in doses of 1-25 of a grain, in hemiplegia, obscurity of vision, spermatorrhoea, and yellowness of the cornea. FERRUM. (IRON.) We employ three preparations of Iron-metallic iron in powder, the tincture of chloride of iron, and the tincture of acetate of iron. The first is iron by hydrogen, or Quevenne's; a good article may be known by its iron-gray color and its effervescing with acids; the spurious is black, and efferves- ces but slightly. The tincture of chloride of iron should be ordered of a reliable manufacturer. It will be a clear, deep- colored tincture, without a trace of yellowness or deposit at the bottom of the bottle. We employ iron as a restorative. It is a component part of the red corpuscles, and experience has shown that its ad- ministration stimulates the formation of these bodies. In proportion as the red corpuscles are increased, blood-making becomes more active and nutrition is improved. It thus be- comes a very important remedy in cases of anæmia, with im- paired nutrition. As a restorative, it is better to administer the necessary quantity of iron with the food. Experiment has demon- strated that at other times it is appropriated slowly or not at all. It does not require a very large amount to accomplish the object, for iron exists in small quantity in the body. The 136 SPECIFIC MEDICINES. • dose of metallic iron need never be more than five grains, often not more than one; whilst of the tincture, the dose will be from one to twenty drops. In the selection of the preparation I would be guided by the appearance of the mucous membrane. If it is deep-red, use the tincture of chloride; if pallid, metallic iron. We also employ iron as a specific against certain zymotic poisons. The reader has probably employed the tincture of chloride in erysipelas, and many regard it as a true specific in the disease, rarely making any other prescription. I think we may say, that in all cases of erysipelas presenting the deep-red discoloration of mucous membranes, with the same deep color of the local disease, the tincture may be prescribed with great confidence. But my experience with the disease has shown me that where the mucous membranes are pallid, the coating of the tongue white and pasty, the sulphite of soda is the best remedy. In these cases Quevenne's iron might be tested. Rademacher claimed that iron was specific to one of his three epidemic constitutions. This was characterized by pal- lor of the skin, moderate heat, with a small, thin or soft, empty pulse. His description, so far as I have seen it in translation, is so meager that we can hardly determine the condition in which he valued it so highly, even treating all the cases of pneumonia in a season with iron alone. The preparation of iron employed by the school of Rade- macher was a tincture of the acetate, prepared by the fol- lowing formula : "Take of pure sulphate of iron two ounces and seven drachms; of the pure acetate of lead three ounces: triturate them together in an iron mortar so long as may be needed to reduce them to a soft conformable mass; then put the mass in an iron vessel with six ounces of distilled water and twelve ounces of diluted acetic acid; heat the mixture until it boils. After it has become cold, add six ounces of pure alcohol. "The mixture is then to be put in a glass vessel with a ground stopper for at least six months-to be shaken daily— 1 FERRUM. 137 when it will acquire a high red color; then it is to be filtered through paper. "By this long process the tincture will have a mild, pleasant taste, and a smell similar to Malaga wine, more noticeable on the addition of gum arabic to the mixture. The older the mixture is the pleasanter the smell and taste, and hence it is desirable to make it in large quantities.” A simpler formula than the above is the one of the Dublin Pharmacopoeia, on page 1253 King's Dispensatory. It is prescribed in doses of gtt. j. to gtt. x.; and will be found an excellent preparation where iron is indicated, and we do not wish the muriatic acid. Recent investigation has shown that the solid blue colora- tion of tongue is an indication for small doses of iron in any disease. For this I would prescribe tincture acetate of iron, Zij.; water, or syrup, 3iv.; a teaspoonful every three or four hours. The majority of our readers are well acquainted with the use of tincture of muriate of iron in erysipelas, and have administered it in this disease with a certainty that they rarely feel with regard to other remedies. I don't think any one, even the most skeptical in regard to specific medication, will question the specific action of this remedy in many cases of this disease. And as it is such a well known example, we will use it to illustrate certain facts in therapeutics. The first proposition I will make is, that it is not specific to all cases of erysipelas. Whilst in many, embracing some of the severest, it is the only remedy needed, in others you might quite as well give water, other than the iron proves a topical irritant. We ask the question, then, in what condition of this dis ease is it specific, and what are the symptoms indicating it use? Or, in what conditions is it contra-indicated, and what are the evidences that show this? It is easier to pick out the case where other treatment would be preferable, and where we would not use the iron. In any case of erysipelas, with a full bounding, or full hard pulse, and bright redness of the local disease. I would always 138 SPECIFIC MEDICINES. prefer veratrum as an internal and a topical remedy. Indeed, nothing is more certain than veratrum in these cases. Take again the case presenting the broad, pallid tongue, with moist, pasty coat, and I would very certainly prefer sulphite of soda; or if it were a moist, dirty tongue, without so much pallor, sulphurous acid. But is it possible to point out the indications for iron? I think it will be if we examine those cases carefully in which iron is the remedy. One of the most pronounced symptoms that I have noticed is a peculiar solid blue color of mucous membranes, sometimes deepening into purple where there is a free circulation. The same change in color may oftentimes be noticed in the local disease. In several cases, other than erysipelas, I have been tempted to prescribe tincture of mu riate of iron from this symptom, and with good results. I hope our readers will watch this point carefully and see if I am correct. If not, find a certain indication for its use. Now for the argument. Take a case of erysipelas of the severest type, in which iron is the remedy-what are the re- sults of its administration alone? The pulse is 120 to 130, small and hard; within forty-eight hours it comes down to 80, and is soft and open. The temperature is probably 106°; in forty-eight hours it comes down to 100°. The skin is dry and harsh, the urine scanty and high colored, the bowels con- stipated; in forty eight hours the skin is soft and moist, the urine free, the bowels act without medicine. The nervous system is in a state of extreme irritation, possibly the patient is delirious; in forty-eight hours the patient is conscious and the suffering relieved. Here we have the most marked effect of a sedative, diaphoretic, diuretic, laxative and cerebro-spinant, and yet we have given but the one remedy, tincture of muri- ate of iron. Now I ask the question, why these results? You answer, because the iron specificially antagonized the blood-poison. Yet tincture of muriate of iron is not re- garded as an antiseptic, and we have a number of cases of erysipelas, in which iron does not antagonize the blood poison. How is this? Is it not well worth thinking of? And if FUCUS. 139 tincture of muriate of iron thus becomes a specific to a cer- tain form of grave zymotic disease, may we not hope to find other remedies of a similar character? I present the subject in this form, that we may think of it, and hope at some future time to give a rational explanation of some of these facts in therapeutics. FRASERA CAROLINENSIS. (AMERICAN COLUMBO.) Preparation.-Prepare a tincture from the fresh root, in the proportion of 3viij. to alcohol 98 per cent. Oj. Dose, gtt. j. to v. This remedy has been but little used, and that little has been of the dried root as a tonic. The recent root possesses quite active properties, and is likely to repay investigation. It is stimulant to the circulation, and will doubtless exert the same influence upon all the vegetative functions. Its continued use will relieve obstinate constipation. FRAXINUS SAMBUCIFOLIA-F. ACUMINATA (ASH.) Preparation.-Prepare a tincture from the recent bark, in the proportion of 3viij. to alcohol 76 per cent. Oj. Dose, from gtt. ij. to f3ss. Both the black and white ash deserve study. The first, for its influence in skin diseases, especially of an herpetic char- acter, and as a general alterative. The second, to improve secretion, and for its influence upon the chylopoietic viscera. FUCUS VESICULOSUS. (SEA WRACK.) Prepare a tincture in the usual manner, using dilute alco- hol. Dose from gtt. v. to 3ss. We wish to determine its influence upon the functions of waste and nutrition, and especially in cases of degenerations and growths. It has had some reputation in the treatment 140 SPECIFIC MEDICINES. of benign and malignant growths. It exerts a direct influ- ence upon the intestinal canal, and this may suggest the course of experiment. The Sea Wrack has been employed in the treatment of scrofula, and to remove deposits and hypertrophy of tissue. Recently it has been largely sold to cure obesity, and persons who have taken it vouch for its curative influence. The ben- efit, however, may be wholly due to an animal diet, and to the limited use of fluids, which is a part of the treatment. FILIX MAS. (MALE FERN.) It The oleo-resin of Male Fern is used as a tænicide, and whilst not so certan as the pomegranate bark, it will be pre- ferred in some cases because the dose is much smaller. should be taken when the stomach is empty, say at 8 or 9 o'clock in the morning, the patient having had no breakfast, in a dose of twenty drops, followed by ten or fifteen drops of sulphuric ether, and in two hours by a full dose of compound powder of Jalap and Senna. FOENUM GRÆCUM. (FENUGREEK.) A sack of ground Fenugreek seed, makes an excellent ap- plication in chronic disease of stomach, bowels and liver. It may be rendered stimulating by sprinkling it with any of the essential oils, hemlock, origanum, cinnamon, etc. In infusion or tincture it is gently tonic, and improves diges- tion, and is thought to relieve irritation of the respiratory apparatus. It has also been used as an emmenagogue, and to relieve uterine irritation. GALIUM APARINE. (CLEAVERS.) Galium is most frequently employed in infusion, especially for its influence upon the urinary apparatus. A tincture may be prepared from the recent herb by expression, using only sufficient alcohol for preservation. GAULTHERIA. 141 The first use of Galium is to relieve irritation of the uri- nary apparatus, and increase the amount of urine. For this purpose it will be found one of our best remedies. In dysuria and painful micturition, it will frequently give prompt relief. It has recently been employed in cancer, used locally and internally. A case of hard nodulated tumor of the tongue, apparently cancerous, is reported in the British Medical Journal, as having been cured with it. Whether it was can- cerous or not, it suggests a line of experiment which may de- velop an important use of the remedy. GALANGA. (GALANGAL.) In powder this pungent root is used as a remedy for the toothache, catarrh, chronic pharyngitis, and laryngitis. A tincture may be prepared in the usual way, with alcohol of 98 per cent, and used in doses of from one to ten drops. It has been of service in dyspepsia, lax and pendulous abdo- men, relaxation of the perineum with hemorrhoids, and as an adjuvant to remedies for syphilis. GALEGA OFFICINALIS. (GOAT'S RUE.) A tincture is prepared from the fresh herb, and used on the Mediterranean and in India as a remedy in dyspepsia, lienteric diarrhoea, tympanitis, and as a restorative in con- valescence from low forms of disease. GAULTHERIA PROCUMBENS. (WINTERGREEN.) Preparation.-Prepare a tincture from the fresh plant, in the proportion of 3 viij. to alcohol 98 per cent. Oj. Dose, from gtt. ij. to gtt. x. In this form and in these doses, the Gaultheria exerts a special influence upon the bladder, prostate and urethra, allaying irritation and inflammation. It may also be employed 142 SPECIFIC MEDICINES. in dysuria. Probably one of its most important uses is, as an anaphrodisiac, exerting a direct and quite certain influ- ence upon the reproductive organs of both male and female. For this purpose it is employed in some cases of sperma- torrhea. It will not do, however, to mistake the case, and use it where the venereal function is already impaired. GELSEMINUM SEMPERVIRENS. (YELLOW JESSAMINE.) The commercial tincture has been so variable in strength that much harm has resulted from its use. In some cases the harm has been direct from over doses, in others, indirect from depending upon a feeble or worthless remedy. Before the war, we had a very crude tincture prepared from the green root, with proof spirits (whisky ?), containing about ast much of the medicinal properties as could be held by such spirit. During the war, there being difficulty in obtaining a supply of the root, and greater difficulty in having it shipped. green, the tincture in the market gradually deteriorated un- til it was worthless. Even yet it has not regained its medi- cinal properties with many druggists. We have thought a good tincture could only be made from the fresh root. But some who have employed the dry root (not old), claim that it makes fully as reliable a tincture. Dr. Locke, of Newport, Ky., prepares his tincture from the dried root, and claims that it is more reliable than any he can buy. It is not worth while to give a formula for the preparation of a tincture, as it will be purchased by a great majority of our readers. That which bears the label "Specific Medicine" will be found very strong. Dose from the fraction of a drop to gtt. vj. Gelseminum exerts a specific influence upon the brain, and to a less extent upon the spinal center and sympathetic. It relieves irritation and determination of blood, and the dis- ordered innervation that flows from it. Probably there is no remedy in the materia medica that is more direct and GENTIANA. 143 } certain in its action. Given, a case of irritation and deter- mination of blood to the brain, marked by flushed face, bright eyes, contracted pupils, restlessness and irritability, we pre- scribe Gelseminum with certainty. This being a common complication in diseases of childhood, it is especially the child's remedy. Acting in this direction, it lessens the frequency of the heart's action, and removes obstruction to the free flow of blood-a sedative. It also increases secretion in the same way. I do not think the Gelseminum exerts any important influ- ence, other than through this action upon the nervous sys- tem. But, as will be observed, this is a very important action. It is contra-indicated where the circulation is feeble, and there is tendency to congestion. Especially if there is a fee- ble circulation in the nerve centers. We never give it if the eyes are dull, pupils dilated, and the countenance expression- less. In such cases, it may prove fatal in quite moderate doses. A number of these cases are on record, three or four in which death was produced by as small a dose as gtt. xxx. of a common tincture. It has one other specific action, which is worthy of mention. It is the remedy in dysuria from stricture, and will rarely fail in enabling the patient to pass urine in from four to eight hours. GENTIANA LUTEA. (GENTIAN.) The Gentian is an excellent stomachic bitter, and resem- bles, in its medicinal action, our hydrastis. I do not think, however, it has the same kindly influence in irritable condi- tions of the stomach. A very fine preparation may be made by taking five parts of Gentian, and one part of podophyllum; and making a tincture by percolation, using dilute alcohol. It is one of the most efficient remedies I have ever used in atony of the stomach and bowels, with feeble or slow digestion. 144 SPECIFIC MEDICINES. GENISTA TINCTORIA. (DYERS' BROOM.) A tincture is prepared in the usual way from the young branches, fresh, using alcohol of 98 per cent. The dose will vary from the fraction of a drop to 3ss. It may be employed in ascites and oedema, with cutaneous disease or erosion of the skin with exudation. GEUM RIVALE. (WATER AVENS.) Prepare a tincture from the flowering plant with alcohol of 98 per cent. The dose will range from the fraction of a drop to ten drops. It is indicated by tearing spasmodic pains in the abdomen, which recur upon taking food or exercise. It is employed in diarrhoea and dysentery, dyspepsia, disease of the respira- tory mucous surfaces, and in leucorrhoea. GLECOMA HEDERACEA. (GROUND IVY.) Prepare a tincture from the fresh plant with alcohol of 98 per cent. The dose will vary from the fraction of a drop to fifteen drops. It may be employed in all diseases of the mucous mem- branes with increased secretion, as bronchitis, catarrhal dis- ease of stomach, chronic mucous enteritis, dysentery, cysti- tis, and leucorrhoea. GERANIUM MACULATUM. (CRANESBILL.) The Geranium is an astringent from the presence of tannic and gallic acids in large quantity; and hence will possess the medicinal properties of these. It is claimed, however, to possess other properties, acting more kindly, and giving tone to mucous membranes. Whilst I believe this remedy has * GLYCERINE. 145 been over-rated, I am confident that experiment will develop some special use. It may be employed in infusion with good results, espe- cially when a topical action on the stomach and bowels is wanted, or in chronic cases when we desire the action of gal- lic acid. For general use I would suggest a tincture by per- colation, using alcohol of 50 per cent. The Geranin, though not entirely worthless, is a feeble and costly medicine. GERARDIA PEDICULARIA. Will some of our southern physicians give this remedy a ial and report. For experiment, make a tincture by perco- ion, 3viij. to the Oj., using dilute alcohol. Test it as a sed- ve, a diaphoretic, and an antiseptic. GILLENIA TRIFOLIATA-G. STIPULACEA. (INDIAN PHYSIC.) Preparation.-Prepare a tincture from the root, in the pro- portion of 3 viij. to proof spirit, Oj. Dose from gtt. v. to 3ss. These indigenous remedies possess marked medicinal pro- perties, yet they have been so little used of late years that most physicians know nothing about them. They deserve careful study. First to determine their re- lation to ipecac, and whether they will replace it in practice. The direction of the experiments may be seen by reference to this agent. We also wish to determine their influence upon the functions of digestion and secretion. GINSENG. (See Panax.) GLYCERINE. Glycerine is principally employed in medicine for its topi- cal action. It is slightly stimulant to both skin and mucous membrane, and shields the skin from the action of the air. In many cases of simple cutaneous irritation, it will prove 146 SPECIFIC MEDICINES. curative alone. In others it will prove a good vehicle for the application of other remedies. In some cases of dys- pepsia, Glycerine is a good remedy, allaying irritation, and giving gentle stimulation. Glycerine is an admirable solvent, and may be used as a basis for many preparations, both for local use, and internal administration. In using Glycerine as a local application, a portion of water should always be added. GNAPHALIUM POLYCEPHALUM. (WHITE BALSAM.) Preparation.-Prepare a tincture from the leaves, us alcohol of 50 per cent. Dose, gtt. j. to 3ss This agent has been but little used, yet we think it wor of investigation. The line of experiment will be, to det mine its influence upon the urinary and reproductive organ -in acute and chronic ulcerations-and its action on the digestive apparatus. GOSSYPIUM HERBACEUM. (COTTON.) Some years since the cotton-root was in considerable de- mand as an abortive. It was claimed that the Negro women of the South made common use of it, and that it was so cer- tain and safe that they could rid themselves of the product of conception whenever they wished, and without impair- ment of health. It was singular what a demand sprung up for cotton root bark; but fortunately for the unborn it had no influence on the gravid uterus. Still the reports from the South seemed well authenticated, that, at least in some cases, it was abortive, and was a very certain emmenagogue, and a stimulant diuretic. It is only another example of a fact I have insisted on, that many plants. possessing medicinal properties when fresh, lose them when gathered at the wrong season and kept in stock. GRANATI. 147 Since the first edition of this work was published, careful experiment has shown that the tincture of the green root is abortive, and especially that it has marked emmenagogue properties. It should not be used when there is irritation. or a tendency to inflammation. It also exerts a direct influ- uence upon the urinary apparatus, increasing secretion and acting as a stimulant to the entire urinary tract. GLONOINE. (NITRO-GLYCERIN.) It is employed in dilution with alcohol, the third to the sixth decimal being recommended. The indications for its use are a sense of fullness in the head, dizziness, flushed face, tensive pain as if the head buld burst, partial loss of consciousness, or difficulty in rawing conclusions from impressions: throbbing in the hole body or in a particular part, as if the arteries were distended with blood, is deemed a good indication for glo- noine. The physician who must always give a large dose had better let this agent alone. GRANATI. (BARK OF THE POMEGRANATE ROOT.) The bark of the Pomegranate root is probably the most certain remedy we have for the expulsion of tape-worm, but in order to succeed, it must be used as recommended. The directions of Prof. Locke for making a decoction are as follows: Put eight pints of water and eight ounces of prepared bark into a kettle and boil until the liquid is reduced to about four pints, then strain through muslin; press well. Add the contents of the strainer again to the same amount of wa- ter (eight pints), and boil until reduced to four pints, and strain as before. Mix the two liquids, and evaporate to the measure of one pint. When cold add to it one fluid drachm of fluid extract of Jalap. This is given in two or three parts, in the morning, the patient fasting. 148 SPECIFIC MEDICINES. GRAPHITES. (PLUMBAGO.) A pure Plumbago is triturated with sugar of milk, ten to ninety parts, making a first decimal; this is repeated to the third trituration, when it is added to alcohol in the pro- portion of ten grains to ninety drops of alcohol. It is this that I have used in practice. The indications for its use are, -a feeble circulation of blood, pallid, transparent skin, pale tongue, impairment of the sexual function (irritation without power), irregular and painful menstruation, leucorrhoea. GRATIOLA OFFICINALIS. (HEDGE HYSSOP.) A tincture is prepared from the fresh plant, using alcoh of 98 per cent. Of gtt. v. to water iv. the dose may be teaspoonful. It may be employed in jaundice, dropsy, engorgement of spleen, fullness and oppression of the brain, and some other diseases where there is an obstructed circulation. Soreness and rawness of the mouth may be taken as an indication in such cases. GRINDELIA ROBUSTA. A tincture is prepared from the recent leaves, using alco- hol of 98 per cent. The dose will range from the fraction of a drop to ten drops. Glycerine may be used in the prescrip- tion to hold the remedy in solution with water. I generally prescribe gtt. x. to 3iv. of glycerine and water; dose, one teaspoonful I have employed it with good results in asthma, bronchor- rhoea, dilated bronchia, old ulcers, and chronic diseases of the skin, with enfeebled circulation. As a local application in the proportion of 3j. to 3ij. in water Oj. I have employed it with marked benefit in the treatment of old and indolent ulcers. GUAIACUM. 149 * GUACO, (MIKANIA GUACO.) A tincture is prepared from the dried leaves (from South America), using alcohol of 98 per cent. As we have an abundance of astringent remedies for diar- rhoea, it is hardly worth while to import one, so that this may be tried in small dose for other effects. It may be tried in rheumatism and visceral neuralgia. GUARANA. The Guarana of the drug market is the ground seed of the Paullinia Sorbilis, a native of Brazil, This is made into a tincture in the usual way with alcohol of 98 per cent. The se will vary from one to ten drops. It is a stimulant to the cerebro-spinal centers, and its incipal use now is to relieve headache. If the face is pal- d, the eyes dull, the face expressionless, it may be used with advantage. It may be given in those severe headaches that recur with the menstrual period, the symptoms being as above, with a prospect of relieving the disease of the repro- ductive function, as well as the headache. GUAREA TRICHILIOIDES. (RED WOOD.) A tincture is prepared from the bark, (Central America), using alcohol of 98 per cent. It is administered in the usual small doses, gtt. v. to water 3iv., a teaspoonful every two or three hours. It is indicated by vertigo, dizziness, variable appetite, cough, and may prove valuable in the early stages of phthisis. GUAIACUM OFFICINALE. We prepare a tincture by percolation from the wood, in the proportion of 3 viij. to alcohol 76 per cent. Oj. Dose, from ten to thirty drops. 150 SPECIFIC MEDICINES. The tincture thus prepared may be occasionally used with advantage in the latter stages of acute, and in chronic rheu- matism. It may also be associated with the vegetable alter- atives in the treatment of some chronic diseases, where stim- ulation of the skin is required. Occasionally it will prove useful in functional diseases of the uterine organs, especially in amenorrhoea. GUILANDINA BONDUCCELLA. An East Indian nut which has been employed in doses of one to ten grains in the treatment of agues, and as a prophy- lactic against malarial fevers. In doses of from one-twenty- fifth of a grain to one grain, it is a remedy in some eruptive diseases, in enlargement of the spleen, hepatic pain, a oedematous swelling; it has also been employed in syphili GYMNOCLADUS CANADENSIS. (AMERICAN COFFEE TREE.) This agent has been but little used in medicine, yet if we are to judge from its common use as a fly poison, it possesses active properties that may be made available. For experi- ment, a tincture may be made of the bark, beans, or pulp of the seed-pod; the last being regarded as the most active. Dr. Herring concluded from his experiments that it might be given with benefit in cases of "cough accompanied or fol- lowed by tonsilitis; in erysipelas of the face; in scarlet fever; in so-called hives; in typhoid fever; in remittent or intermit- tent epidemic fever, with a typhoid character, etc." The dose would be small. Of a tincture of Ziv. of the pulp to the Oj., gtt. x. to water, 3iv., a teaspoonful every three hours would be sufficient. HAMAMELIS VIRGINICA. (WITCH-HAZEL.) I prefer a distilled extract of the fresh leaves to any other preparation. That known to the trade as "Pond's Extract" HAMAMELIS. 151 is employed by most physicians who make use of the remedy. The ordinary fluid extract may be used as a topical applica- tion, as a gargle for the throat, and for the general purposes. of an astringent. Where the Witch-Hazel can be readily obtained, I would advise that the leaves be gathered in June or July, and if no apparatus for distilling is at hand, that they be packed in a percolator, and a tincture prepared with a very weak spirit, say 30 per cent. The Hamamelis has a specific action upon the venous sys- em, giving strength to it, and facilitating the passage of ven- blood. It may, therefore, be employed with advantage any case where a part is enfeebled, and there is a sluggish rculation. Thus we use it in cases of catarrh and ozæna ; ronic pharyngitis, disease of the tonsils, pillars of the fau- , vellum and uvula, and in chronic laryngitis. The indi- tions for its employment are, thickening of mucous mem- anes, with enfeebled circulation, and increased secretion, ither mucous or muco-purulent. It is especially a valuable remedy in the treatment of hem- orrhoids, sometimes effecting a cure in old and very stubborn cases without the use of other remedies. Usually, however, I use the solution of the persulphate of iron as a local appli- cation. It is also a very useful remedy in the treatment of diseases of the uterus and vagina. Given, a case with the conditions named, thickening, with relaxation, enfeebled circulation, and increased mucous, or muco purulent secretion, and its action is very positive. We employ it also in the treatment of various lesions of the lower extremities, both as a local application and an internal remedy, and many times with excellent results. It is an excellent dressing for erysipelas, and for burns, giving that slight stimulation that seems to be required in these cases. I need not name other cases, as the indications for its use first given, will suggest its application. I value the remedy 152 SPECIFIC MEDICINES. very highly, and feel confident that a trial in the cases named will bring it into general use. HEDEOMA PULEGIOIDES. (PENNYROYAL.) This is a much neglected article, probably because it is so common. I regard it as one of the most valuable stimulant diaphoretics; very kindly received by the stomach, and quite certain in its action. As a remedy for colds it will prove very useful. To two ounces of the tincture add gtt. x. of tincture of veratrum, or 3ss. of tincture of ipecac, and give it in teaspoonful doses every one or two hours. It is an admirable remedy for amenorrhoea from cold; the safest and most certain we have, I think. It may be given in doses of a teaspoonful every hour or two hours, or two three times in the evening, with the hot foot bath. Prepare your own tincture in this way: In July, gather sufficient quantity of the herb, stem it, and at once pack th leaves in a percolator. Then add dilute alcohol, or even com mon whisky, in the proportion of Oj. to each 3 viij. Let it stand twenty-four hours, and then draw off, putting on water until the tincture measures Oj. to each 3viij. HEUCHERA AMERICANA. (ALUM ROOT.) This agent has been used in domestic practice in the treat- ment of sore throat, diarrhoea, dysentery, leucorrhoea, and for the general purposes of an astringent. It may have other properties, and it would be well to give it a thorough inves- tigation. HELLEBORUS NIGER. (BLACK HELLEBORE.) Prepare a tincture from the root, using alcohol of 98 per cent. Of a preparation of gtt. v. to water 3iv. the dose may be a teaspoonful every two or three hours. It may be employed as a stimulant to the menstrual flow, when the patient complains of flashes of heat, burning of the HEPATICA. 153 surface, especially of nates and thighs, and sensitiveness of the perineal and pelvic structures. It may also be thought of in the treatment of hypochondria and hysteria. HIERACIUM VENOSUM. (RATTLESNAKE WEED.) Prepare a tincture from the recent plant, using alcohol of 98 per cent. It may be administered in the usual way—gtt. v. to x. in water 3iv.; dose, one teaspoonful. It has had a reputation as an antidote to the bite of poison- ons snakes, and probably possesses some power in this direc- tion. It has also been named as a remedy in chronic catar- rhal disease and in scrofula. HELONIAS DIOICA. (UNICORN ROOT.) True Helonias undoubtedly exerts a marked influence up- on the reproductive organs of the female, but as it is so fre- quently supplied from the Aletris, but little dependence can be placed upon it. It exerts the general influence of a tonic, and a special tonic action upon the urinary and uterine organs. It is pos- sible that if we can obtain a reliable preparation, it will be found superior to other remedies for these purposes. One of the special indications for its use is in the mental depression and irritability that attends many of these affections. I am of the impression that, in many cases, the relief of this cere- bral disturbance is its most important action. HEPATICA AMERICANA. (LIVERLEAF.) Prepare a tincture from the fresh leaves, using proof spirit. Dose, gtt. j. to 3ss. The Hepatica exerts a slightly stimulant and tonic influ- ence upon the stomach and small intestines, relieving irrita- tion and promoting functional activity. Thus it may be em- 154 SPECIFIC MEDICINES. ployed in atonic conditions of these and associate viscera with advantage. Culpepper wrote, "It is a singularly good herb for all diseases of the liver, both to cool and cleanse it, and is serviceable in yellow jaundice. It is a singular remedy to stay the spreading of tetters, ring-worms, and other fret ting and running sores." It exerts an influence upon all mucous surfaces. Probably its best action is upon the bronchial mucous membrane,when enfeebled from inflammation or irritation, attended with pro- fuse secretion. In these cases it may sometimes be given with great benefit. HERACLEUM LANATUM. (MASTERWORT.) This remedy has been but little used, but it might repay careful study. It has been employed as an antispasmodic, and we would judge that it was a spinal stimulant. For ex- periment a tincture should be prepared from the green root. The Wild Parsnip (Pastinaca Sativa) might also be tested. In poisonous doses it produces great excitation of the ner- vous system, semetimes with convulsions, followed by coma and difficult respiration. This would suggest its use as a cerebro-spinal stimulant. Of course it would be used in small doses. HYDRASTIS CANADENSIS. (GOLDEN SEAL.) I will give the Hydrastis a brief notice, as it is in such general use for all the purposes of a tonic, that my readers kuow as much about it as I do. It improves the appetite and facilitates digestion; but beyond this it relieves, gastro- intestinal irritation. Its topical action, however applied, is that of a tonic, strengthening the circulation and nutrition. It is in com- mon use for these purposes, in diseases of the skin, diseases of the eyes, and diseases of the mucous surfaces. As a stomachic and tonic, I like the action of the finely HYDRANGEA. 155 powdered root, as well as the more costly preparations. Indeed, in most cases, I would prefer this, in equal quantity, to the Hydrastine. A tincture made with alcohol of 50 per cent. will be found a good preparation. It is more convenient for carrying, and added to water, gives a pleasant stomachic. A very good prescription would be: R Tincture of Hydrastis, 3ij.; tinct. of Nux vomica, gtt. xx.; water, 3iv. A teaspoonful every three or four hours. The Sulphate of Hydrastia is (when properly made) solu- ble in water in the proportion of two grains to the ounce; the Phosphate four grains, and the alkaloid, Berberina, as much as twenty grains to the ounce of water. They make a valua- ble collyrium in chronic conjunctivitis. or the latter stages of the acute. They are also admirable injections in the second stages of gonorrhoea, and in gleet. HYDRANGEA ARBORESCENS. (SEVEN BARKS.) Preparation.-Prepare a tincture from the fresh or recently dried root, Zviij. to the Oj., using alcohol of 76 per cent. Dose, gtt. x. to 3ss. This is a valuable remedy in diseases of the urinary appa- ratus. It gives tone to the kidneys, improving their func- tional activity, and thus tends to arrest the formation of uri- nary deposits and calculi. We do not believe, as Dr. J. W. Butler stated, that it will cure stone in the bladder, though it may prove prophylactic. It relieves irritation of the blad- der and urethra, and hence proves serviceable in cases of gravel. It also exerts an influence upon the respiratory mu- cous track, relieving bronchial irritation. HYDROCOTYLE ASIATICA. (WATER PENNYWORT.) A tincture is prepared from the plant (Asiatic, though the American species, Ranunculoides and Americana, proba- bly possess the same properties), with alcohol of 98 per cent. 156 SPECIFIC MEDICINES. The dose will be small, from the fraction of a drop to three drops. It may be employed in chronic skin diseases, and in syph- ilis with disease of the skin. HYDROCYANIC ACID. We employ the dilute hydrocyanic acid of the Pharmaco- poeia of which five drops may be added to water 3iv. and given in doses of one teaspoonful. It is employed to relieve irritation of the stomach, and check vomiting from this cause, in gastralgia, excited action of the heart from gastric irritation, and to check gastric coughs. HYPERICUM PERFOLIATUM. (ST. JOHN'S WORT.) Preparation. We prepare a tincture from the fresh herb, 3viij. to Oj., with alcohol of 76 per cent. The dose is small: of gtt. x. to gtt. xxx. to water ziv., a teaspoonful every one or two hours. According to our Homeopathic friends, the special symptom indicating its use is, “sensation in the forehead as if touched by an ice-cold hand, in the afternoon, after which a spas- modic contraction in right eye." We would be glad to have the remedy thoroughly tested in diseases of the urinary appa- ratus, and in nervous affections with depression. Will some of our readers try it and report. HYOSCYAMUS NIGER. (HENBANE.) Preparation. We prepare a tincture from the recent dried leaves in the proportion of 3viij. to alcohol 76 per cent. Oj. Dose, from gtt. ss. to gtt. v. In medicinal doses the Hyoscyamus is a stimulant to the cerebro-spinal centers, and may be employed whenever such action is desirable. It is from this that it has its sleep-pro- IGNATIA. 157 ducing properties, as well as the relief of pain. With some persons the tolerance of Hyoscyamus is very great, and even drachm doses exert this stimulant influence. It exerts a similar influence upon the vegetative system, in a slight degree favoring every process that is performed un- der its influence. It is not only stimulant, but it allays irri- tation. Thus, in some cases, where a frequent pulse is de- pendent upon irritation and debility of the cardiac nerves, it exerts the influence of the special sedatives. It never arrests secretion, but, as before remarked, it favors it. Thus small doses of Podophyllin, combined with Hyoscyamus, is not only less irritant, but more effectual. So we find in irri- table states of the digestive apparatus, the addition of a small portion of Hyoscyamus to the bitter tonics improves their action. Because Hyoscyamus is poisonous, it is no reason why it should be an active remedy. Poisoning and curing are two different things. Whilst it will be found a valuable curative agent, and quite direct in its action, its influence is rather feeble than otherwise, and too much must not be expected from it. The difference between a poison and a medicine, in this case, is a matter of dose alone, and in this respect it differs from some other medicines. IGNATIA. (ST. IGNATIUS' BEAN.) A tincture is prepared from the ground seed, with alcohol of 98 per cent., macerating for a time with gentle heat. I add gtt. v. to water 3iv., of which the dose will be one tea- spoonful. The indications for it are, dragging pains in right hypo- chondrium, with gastrodynia, deep seated pain in the loins, uterine colic, dysmenorrhoea with colic, atony of reproduc- tive organs, wandering pains in pelvis. Our Homoeopathic friends say that Ignatia is a remedy for women, Nux or Strychnia for men. 158 SPECIFIC MEDICINES. IMPERATORIA OSTRUTHIUM. (MASTERWORT.) A tincture is prepared from the root, using alcohol of 9 per cent. In the usual proportion of gtt. x. to water iv. it may be given in doses of a teaspoonful. It has been used as a stimulant in typhoid fever, in deliri- um, delirium tremens, in ague, colic, hysteria, and asthma. INULA HELENIUM. (ELECAMPANE.) Preparation.-Prepare a tincture from the fresh root, in the proportion of 3 viij. to alcohol 76 per cent. Oj. Elecampane is a feeble stimulant and tonic, but may some- times be used for these properties with advantage. It not only exerts this influence upon the digestive track, but also the skin, and is sometimes beneficial in chronic cutane- ous diseases. upon Its principal use, however, is in bronchial disease, with increased secretion. It may be used also in combination with Stillingia. Its action is slow, and it needs to be con- tinued for some time to experience its benefits. IODINE. Iodine, in all its forms, increases retrograde metamorpho- sis, and, in some degree, stimulates excretion. We have no reason to believe that it stimulates blood-making or nutri- tion, other than as it facilitates the removal of worn-out tissues. In quite small doses Iodine stimulates the sexual organs. and increases their power. For this purpose we may use it in the proportion of: R Tincture of Iodine gtt. xx., simple syrup 3iv.; a teaspoonful four times a day. Iodide of Potassium is doubtless its most active form as a resolvent and a stimulant of waste. There is great difference of opinion with regard to the proper dose; some think it best in doses of one to five grains; others in doses of grs. xx. to IODINE. 159 xl. three or four times a day. Of course our choice of dose will depend upon the strength of the patient, the character of the disease, and the rapidity of action desired. The indication for this salt is, a broad, pallid, leaden- colored tongue, rather full. With this indication it is a very certain antisyphilitic, whilst with a red and contracted tongue, it is pretty sure to do the patient injury. The Iodide of Sodium has been but little used, and is ob tained with difficulty in the market, I believe that it is a better preparation than Iodide of Potassium, especially where there is asthenia and a feeble circulation. The Iodide of So- dium may be employed with especial advantage in those cases that present a pallid tongue and mucous membranes. The Iodide of Ammonium should be selected when stimu lation of the nervous system is desirable. Like the others, it increases waste, but it also improves nutrition, and does not impair digestion. In secondary syphilis of an asthenic type, with nervous symptoms, this salt will be found an im- portant remedy. I would call especial attention to its action in certain forms of chronic headache, depending upon an enfeebled circula- tion and mal-nutrition. In some of these cases it gives prompt relief, and effects a permanent cure. We prepare an Iodide of Ammonium for local use as fol- lows: R Tincture of Iodine (strong) aqua ammonia (strong), aa., put in a bottle and allow it to stand until colorless. Its influence is much better than the tincture of Iodine alone ; it is less irritant and does not discolor the skin. It is a favorite preparation with me in the treatment of boils, local inflammations, buboes, etc., in the early stage, when we may expect resolution. + Iodide of Starch is an excellent preparation, affording the best means of giving Iodine without gastric irritation. It may be readily prepared in the office as follows: Triturate twenty-four grains of Iodine with a little water in a mortar, adding gradually an ounce of finely powdered starch, contin- uing the trituration until it assumes a uniform blue color, 160 SPECIFIC MEDICINES. It is then dried with gentle heat, and kept in a well stopped bottle. The dose will vary from five grains to a teaspoonful, given in gruel. IPECACUANHA. (IPECAC.) Preparation.-Prepare a tincture from the root (a good ar- ticle) viij. to alcohol 98 per cent. Oj. Dose from the fraction of a drop to gtt. v. Ipecacuanha exerts a specific influence upon mucous mem- branes, relieving irritation, and arresting the inflammatory process. It also stimulates a better circulation and innerva- tion, increases nutrition, and thus favors functional activity. We employ it as a specific in most cases of cholera infan- tum. It allays irritation of the stomach, gradually checks the frequency of the discharges from the bowels, and restores tone and functional activity. In a large experience in the treatment of this disease, we have found nothing to equal it. It is usually prescribed in the following proportions: R Tincture of Ipecac, gtt. v. to gtt. x.; water iv. A teaspoon- ful every hour. Aconite is frequently prescribed with it in this case. We employ it with very marked advantage in the treat- ment of infantile pneumonia, associated with aconite and veratrum. In some cases, the prescription of Ipecac alone will be sufficient to arrest the disease in two or three days, especially if given in the first stages. It is also employed with excellent results in diseases of the respiratory appara- tus of the adult. We prescribe it in all cases of muco-enteritis. If there is little constitutional disturbance, Ipecac is used alone; if there is some hardness and increased frequency of the pulse, it is given in combination with Aconite. We employ it in dysentery, especially in the sporadic form from cold. The simple prescription of Ipecac is frequently successful, but with much febrile action it is associated with a sedative. IRIS. 161 In small doses we employ it as a stimulant to the entire digestive tract, associating it with the bitter tonics, or the restoratives. For this purpose, it will prove very valuable, especially where there is some gastro-intestinal irritation. IPOMEA JALAPA. (JALAP.) So far as I know, this remedy has only been employed as a cathartic. It would be well to test it in doses so small that no catharatic action would follow; some desirable property might be developed. IRIS VERSICOLOR. (BLUE FLAG.) We find the Iris described in our Dispensatory as "among the most valuable of our medicinal plants," "termed the mer- cury of Eclectic practice," and yet I am safe in saying that there has not been a good article in the market for a dozen years. The dried root of the drug trade possesses no more medicinal property than sawdust, and preparations from it, whether in the form of fluid extract or Irisin, are an impo- sition. We would prepare a tincture from the fresh root, using alcohol of 98 per cent. There are two varieties of it, and that should be selected which presents a bluish mottled color on incision. When prepared as above, the Iris is one of our best reme- dies. It is directly stimulant to waste and excretion, and also influences the lymphatic system. It may, therefore, be employed in all diseases in which there is bad blood, and im- perfect nutrition. I regard it as one of our most certain remedies in the treatment of secondary syphilis. It exerts a specific influence in cases of enlargement of the thyroid gland, and has effected cures in very severe cases. Here, as in other cases, we employ it uncombined, giving it internally, and using it as a local application. The dose of the tincture of Iris will vary from the fraction of a drop to ten drops. 14 162 SPECIFIC MEDICINES. JABORANDI. The leaves of the Pilocarpus pennatifolius (Brazil) are made into a tincture in the usual way, with alcohol of 98 per cent. The dose will vary from the fraction of a drop to one drachm, according to the action required. It is one of the most active diaphoretics known; a drachm and a half of the powdered leaves in infusion, or a drachm of the tincture, in six ounces of hot water, taken in three or four doses inside of an hour, will produce profuse diapho- resis. It has been given in puerperal convulsions, threatened puerperal fever, to arrest the paroxysm of an intermittent, at the commencement of a bilious fever, in the early stages of rheumatism, and in dropsy. The alkaloid, Pilocarpin, may be used by hypodermic in- jcction, in doses of one-sixth to one-fiftieth of a grain, and pro- duces the same effects as the drug given by mouth. JUGLANS CINEREA. (BUTTERNUT.) Preparation.-Prepare a tincture from the fresh inner bark, in the proportion of 3 viij. to alcohol 76 per cent. Oj. Dose, from the fraction of a drop to five drops. In minute doses, the Juglans exerts a marked influence upon the skin, and may be employed in either acute or chronic skin disease. Its influence in this direction requires study. It also allays irritation of mucous membranes, and pro- motes their normal function. In some cases of intestinal dyspepsia, it will be found to give much better results than the bitter tonics. A valuable laxative may be formed by making a watery ex- tract of the Juglans, adding some aromatic to render it pleasant. I have a distinct recollection of the use of Butter- nut extract in the olden time to cure ague. It was given in large doses, and the catharsis would last for days, its influ- ence being so constant and powerful that the patient would KALMIA. 163 not have inclination or time to shake. In small doses, it leaves the bowels in a soluble condition, and is one of the few cathartics that may be employed to overcome obstinate constipation. JEFFERSONIA DIPHYLLA. (TWINLEAF.) Preparation. Prepare a tincture from the recent root, 3viij. to alcohol of 76 per cent. Oj. Dose, from gtt. j. to gtt. xx. The Jeffersonia is a stimulant to mucous membranes, increasing their circulation, and checking profuse secretion. It may be employed in any case where these influences are desirable, and will give satisfaction. It exerts a feebly stim- lant influence upon the skin, sufficient, however, to make it useful in chronic skin diseases. It is also claimed to be diuretic and anti-rheumatic. The remedy requires study, and may develop valuable properties. JUNIPERUS SABINA. (SAVIN.) Preparation.-Prepare a tincture from the Savin, in the proportion of 3viij. to alcohol 76 per cent. Oj. Dose, from gtt. j. to gtt. v. Thus prepared, the Savin is a stimulant. It may be em- ployed in menorrhagia, and in atonic leucorrhoea, with advan- tage. It may also be used as a stimulant in vesical catarrh, and in diseases of the urethra. In some cases of amenor- rhoea it may be employed as a stimulant, but never in those cases presenting excitement of the circulation. KALMIA LATIFOLIA. (SHEEP LAUREL.) Preparation. Prepare a tincture from the recent leaves, in the proportion of 3 viij. to alcohol 76 per cent. Oj. Dose, from gtt. j. to gtt. v. 164 SPECIFIC MEDICINES. This is a favorite remedy of Prof. King, and he describes its use as follows: "It is an efficient remedy in primary or secondary syphilis, and will likewise be found invaluable in febrile and inflammatory diseases, and hypertrophy of the heart, allaying all febrile and inflammatory action, and les- sening the action of the heart. In active hemorrhages, diarrhoea, and dysentery, it has been employed with excellent effect. I have extensively used this agent, and regard it as one of the most efficient agents in syphilis; and have, like- wise, found it very valuable in inflammatory fevers, jaundice, and ophthalmia, neuralgia and inflammation.” I have employed it in secondary syphilis and atonic chronic inflammations with marked advantage, but have not used it for other purposes. Will some of our readers test it in the treatment of fever and inflammation to determine its analogy to the sedatives? KRAMERIA TRIANDRA. (RHATANY.) In the large dose Rhatany has been used for the ordinary purposes of an astringent, and is quite as good as many of the new remedies which depend for their effect upon tannic acid. In small dose it may be employed in gastric catarrh, dyspepsia with full, relaxed skin, incontinence of urine, gleet, prostatorrhoea, leucorrhoea, and in some cases of catarrh. A tincture may be prepared in the usual way with alcohol of 98 per cent. Of this gtt. x. to gtt. xx. may be added to water 3iv., and given in doses of a teaspoonful. LABURNUM. A tincture is prepared from the recent bark, using alcohol of 98 per cent. It may be dispensed in the usual way, gtt. x. to water 3iv., a teaspoonful every one to three hours. The Laburnum relieves irritation of the mucous surfaces, and for this purpose it may be administered in nervous dys- pepsia, the restlessness and uneasiness that follow overwork LACTUCA. 165 (mental), and the excitation of gastric and hepatic nerves, which causes frequent attacks of vomiting from slight exci- tation. LAC. (MILK.) Milk is a favorite article of diet in acute disease, where the patient maintains a high temperature, and burns his tissues to do it. It is usually given hot, with a small portion of salt added, because hot milk is more readily digested. In some cases of dyspepsia, especially where there is much gas- tric irritation, restlessness, uneasiness, sleeplessness, an en- tire milk diet is sometimes of very great advantage. In some cases skimmed milk is used, because the patient can not digest the fat of cream. In Europe, especially in Switzerland and some parts of Germany, they have "milk-cures," which are largely patron- ized, and have excellent success. They are usually in the Highlands, and people go up the mountain side to take their pint of milk, thus having air and exercise as a part of the cure. But in other cases the goats or cows are driven to the door, and milked for the patient. It is always taken fresh and warm from the cows or goats. Serum lactis-whey—is an excellent diet drink in acute dis- eases, fevers and inflammations. If the tongue is pallid, it is sweet whey made from fresh cow's milk by the addition of If the tongue is red, it is acid whey, made by adding bitartrate of potash or citric acid to boiling milk. rennet. LACTUCA VIROSA. (LETTUCE.) We prepare a tincture from Lactucarium, Ziv. to alcohol 98 per cent. Oj. Of this the dose will vary from the fraction of a drop to ten drops; add gtt. x. to gtt. xx. to water iv., and give a teaspoonful every hour. It may be given with the special sedatives to give rest to the nerve centers, and it will sometimes produce sleep in the small dose, when the large will do no good. 166 SPECIFIC MEDICINES, LAPPA OFFICINALIS. (BURDOCK.) Prepare a tincture from the seed, using alcohol of 98 per cent. The dose will vary from the fraction of a drop to ten drops. It acts directly and very kindly upon the urinary apparatus, increasing secretion, and removing irritation. Its action in this respect is especially beneficial in chronic disease, where old tissue is to be renewed, and the saline diuretics can not be used. It may also be employed to relieve bronchial irri- tation and check cough, there being the general indications for the class of remedies known as alterative. LARIX AMERICANA. The American Larch deserves study, not in combination, as it has been employed, but singly, to determine its real medicinal value. For this purpose a tincture may be pre- pared from the recent bark, in the proportion of 3 viij. to alcohol 76 per cent. Oj. It has been employed in combina- tion for a large number of diseases, but its influence upon mucous membranes and upon the skin, is probably most definite. LAURUS SASSAFRAS. (SASSAFRAS.) A very good preparation of the Sassafras for office use, is a tincture of the bark of the root by percolation, using dilute alcohol. It forms a pleasant vehicle for many remedies, when we desire a gently stimulant and astringent action. Tinc- ture of podophyllum added to it, in the proportion of zij. to iv., in teaspoonful doses four times a day, forms an admira- ble alterative. In the treatment of secondary syphilis, especially where manifesting itself in disease of the skin, the infusion will be found preferable. In this case I would direct an infusion of Sassafras with a small portion of Podophyllum, 3ss. of the LEPTANDRA. 167 first, grs. x. of the second, to the pint of water, three times a day. It may be associated with the vapor bath, spirit-va- por bath, or sulphur bath in stubborn cases. LAVANDULA VERA. (LAVENDER.) Lavender is the child's stimulant, and nothing, so far as I am aware, exercises so kindly an influence upon the digestive apparatus and the nervous system. A tincture may be formed of Oil of Lavender, 3ij.; dilute alcohol, Oj. But the Com- pound Spirit will probably answer the needs of most physi- cians. I would like to test a tincture of the fresh herb, and if any of our readers are so located as to grow it, and prepare such tincture, we will be obliged if they will report. LEDUM LATIFOLIUM. (LABRADOR TEA.) A tincture may be prepared from the fresh leaves, using alcohol of 98 per cent. The dose will vary from the fraction of a drop to ten drops. In minute doses it relieves difficult respiration, checks cough, and aids expectoration. It also increases secretion of urine, and sometimes relieves pruritus. LEPTANDRA VIRGINICA. (BLACK ROOT.) For general use prepare a tincture of the Leptandra, 3 viij. to Oj, using alcohol of 76 per cent. For some purposes the infusion would be preferable, but is so nauseous that most persons object to it. The dose of the tincture as above will vary from gtt. ij. to gtt. xx. The Leptandra exerts a gentle stimulant influence upon the entire intestinal tract, and its associate viscera, and in medicinal doses strengthens functional activity. Its action in this direction is so persistent that it might be called a gastro-intestinal tonic. There are some functions not well 168 SPECIFIC MEDICINES. understood, as of the liver and spleen, and it would not much improve our knowledge to say that it acted upon these. But it exerts a marked influence in those diseases in which there is enfeebled portal circulation, and tendency to stasis of blood. Thus in some cases of typhoid fever occurring in malarial localities the Leptandra has proven a very valuable medicine. We do not believe there is any remedy that acts upon the liver, according to the old idea of medicine. It has been conclusively proven that preparations of mercury do not, and that podophyllin does not; and it is probable that we will have to give up the idea of cholagogues entirely. There is no doubt in my mind, however, that Leptandra does influence the function of the liver; not always to increase secretion of bile, but rather to bring the organ back to normal functional activity, whatever may have been the deviation. Associated with the milder bitter tonics, the Leptandra improves the digestive function, and stimulates normal excre- tory action from the bowels. This latter influence some- times makes it a valuable adjunct to those remedies called alterative. It has been employed in the treatment of intermittent fever with excellent results. Dr. Rolph writes that "for many years my father's family employed it exclusively, and though living in a malarial region, they were entirely exempt from ague. They used a tincture of the recent root, taking it before each meal." Quite a number of my acquaintances ´employ it after the chill has been broken with quinine, and claim that its influence in preventing a recurrence is more decided than that of any other remedy. LEPTANDRIN. The best Leptandrin of the market is a dried alcoholic extract; the strongest is obtained by adding a portion of Podo- phyllum before tincturing. The resin is nearly worthless. The dried extract proves a very good remedy in many cases, and may be used for the same purposes as named for the tincture or infusion. LIRIODENDRON. 169 LIATRIS SPICATA. (BUTTON SNAKEROOT.) Preparation.-Prepare a tincture from the recent root, 3 viij. to alcohol 76 per cent. Oj. Dose, from gtt. j. to x. The Liatris is gently tonic, and stimulates secretion from all the emunctories. Hence it has been added to various alterative combinations, and by some practitioners is very highly esteemed. It acts more directly upon the urinary apparatus, and probably upon the reproductive apparatus of both male and female. LIQUIDAMBAR STYRACIFLUA. (SWEET GUM.) Some years since we had sweet gum, the exudation from this tree, recommended for the cure of asthma, and a num- ber of cases from the South were given as proof. But exper- iments in the Northern States were not favorable. I judge, however, from some reports of Southern physicians, that the recent bark contains valuable medicinal properties, as does the fresh exudation. For experiment I would suggest the preparation of a tincture from the fresh bark, using alcohol of 76 per cent. Its influence is probably most marked on mucous membranes, and probably it influences innervation from the pneumogastric and from the spinal cord. LIRIODENDRON TULIPIFERA. (YELLOW POPLAR.) Preparation.-Prepare a tincture from the fresh root bark of the Yellow Poplar, using dilute alcohol. Dose, from gtt. j. to gtt. x. The great abundance and wide distribution of these trees. the ease with which it may be obtained and prepared, and the really valuable character of the remedy, should bring it into general use. It is stimulant and tonic to the digestive apparatus, improving digestion and blood-making. It also exerts an influence upon the nervous system, strengthening innervation and relieving those symptoms called nervous. 1- 170 SPECIFIC MEDICINES. LOBELIA INFLATA. (LOBELIA) Preparation.-Prepare a tincture from the ground seed, 3 viij. to alcohol 98 per cent, Oj. Dose, from the fraction of a drop to ten drops. The common use of Lobelia as an emetic is so well known that little need be said about it. In the form of the Com- pound Powder of Lobelia, or the Acetous Emetic Tincture of the Dispensatory, it gives us our most valued emetic when properly used, To obtain the curative effects of a Lobelia emetic, the remedy should be given in small quantities fre- quently repeated, as it can be absorbed from the stomach, so that emesis, when it does occur, shall be from the general in- fluence of the remedy in the blood, and not from its local irritant influence upon the stomach. Many physicians fail ⚫ to obtain the benefit they have reason to expect because of its improper administration; it is not absorbed, but simply irritates the stomach. Lobelia as prepared above is one of the most powerful vital stimulants in the materia medica. It strengthens the circu- lation, improves innervation, and by its influence upon the sympathetic nervous system gives increased activity of all the vegetative functions. These influences come from minute doses, one drop or less. I usually prescribe it in this pro- portion: R Tinct. Lobelia gtt. x. to xx., water 3iv.; a tea- spoonful every one or two hours. In some cases where there is necessity for a speedy action, as in cases of angina pectoris or neuralgia of the heart, I give one or two full doses of twenty drops. This preparation of Lobelia is specific in difficult labor from rigid os, vagina, or perineum. It also stimulates the contractile function of the uterus, and thus strengthens the pains. This use of Lobelia will be greatly prized when known. In tardy or difficult labor add 3j. of the tincture to 3iv. of water, and give a teaspoonful every fifteen minutes until slight nausea is produced, then in smaller quantities. In rigid os or perineum, I frequently employ it in the same LYCOPUS. 171 way, and with excellent results, but in other cases give it in larger doses until nausea is induced. Lobelia is a sedative, occupying a place between veratrum and aconite. I would be glad if each reader would put the tincture of the seed in his pocket case and employ it in fevers and inflammations in the same doses in which he uses vera- trum I think it will prove very valuable, especially where there is necessity for stimulation. LYCOPUS VIRGINICUS. (BUGLE WEED.) Preparation.-Prepare a tincture from the fresh plant gathered in July and August at the time of flowering, using 3 viij. to alcohol 76 per cent. Oj. The tincture of Lycopus prepared as above, will be found a very valuable remedy, and will take place with veratrum and aconite. It is a very certain sedative, where increased frequency of pulse is dependent upon want of power. For this purpose we employ it in all forms of chronic disease with frequent pulse, and in the advanced stages of acute disease where there is great debility. No remedy is more certain in its action in these cases; and we will find that as the pulse is reduced in frequency, it is increased in strength, and there is a more regular and uniform circulation of blood. The remedy evidently acts upon the sympathetic system of nerves, and we not only have an improvement in the circula- tion, but every vegetative function feels its influence. Thus it improves the appetite and blood-making, nutrition and secretion. It has been employed more extensively in the treatment of hemoptysis than in any other disease. In these cases its action is slow, but very certain, and its influence seems to come from its sedative action-in this it resembles digitalis. Employed in phthisis, we find it relieving the cough, check- ing night sweats and diarrhoea, lessening the frequency of the pulse, improving the appetite and giving better digestion. We observe the same influence from the protracted use of 172 SPECIFIC MEDICINES. veratrum in these cases, evidencing the relationship between the remedies. Those who live where the Bugle weed can be gathered, should not neglect the opportunity of procuring the fresh plant and preparing a tincture for the coming year. I am satisfied that it will well repay the trouble. LIGUSTRUM VULGARE. (PRIVET.) The old use of an infusion of Privet for sore mouths and sore throat will be remembered, and will suggest its further use in irritation of mucous membranes elsewhere. A friend of mine has employed a tincture of the fresh leaves with ad- vantage, and thinks it might take the place of more expen- sive medicines. LEONURUS CARDIACA. (MOTHERWORT.) Prepare a tincture from the fresh root, with dilute alcohol in the usual proportions. The line of experiment will be to determine its influence upon the reproductive organs, and upon the nervous system. The dose may vary from five to twenty drops. LIMONIS SUCCUS. (LEMON JUICE.) Lemon juice, or lemonade, is used in fevers and inflamma- tions, with much advantage, if the patient's tongue is bright. 'red and elongated. The simple desire for an acid drink is sometimes a sufficient indication. It is a specific in certain cases of rheumatism-with the indications above named-and will cure when other remedies fail. No stronger proof of the doctrine of specific medica- tion could be wanted than the fact, that of two cases of rheu- matism seemingly alike, one will be cured with soda, the LUPULIN. 173 other with lemon juice. But if we examine these cases we will find that one has a pallid tongue, the other a red tongue. Lemon juice may also be used in the treatment of enlarged tonsils and uvula; one or two applications a day being made with a camel's hair pencil. LINARIA VULGARIS. (BUTTER AND EGGS.) In Germany an ointment is made by digesting two parts of the plant with one part of alcohol, and then with ten parts of lard until the alcohol has evaporated. Or the fresh plant is bruised and covered with ten parts of hot lard or mutton tallow. It forms an excellent soothing ointment, and has been extensively used for hemorrhoids. A tincture is prepared from the fresh plant, with alcohol of 98 per cent; of this, gtt. x. to water iv. may be given in doses of one teaspoonful. It may be used in scrofula, enlargement of spleen and liver, jaundice, disease of skin, and "bad blood." LUPULINA. (LUPULIN.) The yellow powder separated from the strobiles of the hop, may be administered in doses of from one to five grains to relieve irritation of the nerve centers, to give rest, and pro- cure sleep. In some cases where the irritation is due to sex- ual excitement or abuse, Lupulin exerts a very good in- fluence. A tincture of the hop, may be occasionally employed in dyspepsia, with restlessness and a disposition to brood over troubles. It may also be used, following a meal, when the food undergoes fermentation, giving rise to unpleasant eruc- tations. 174 SPECIFIC MEDICINES. • LYCOPODIUM CLAVATUM. (CLUB-MOSS.) A tincture is prepared from the fresh plant, before it casts its sporules, in the usual way, with alcohol of 98 per cent. The Lycopodium (sporules) is triturated dry in a porcelain mortar until it becomes a doughy mass, then placed in a per- colator and covered with alcohol and allowed to macerate for four days, when it may be drawn off in the usual way. Of either of these gtt. x. may be added to water 3iv. and given in doses of one teaspoonful. The tincture of the plant may be given in chronic disease of the kidneys, when there is blood in the urine; in cases of cough with bloody expectoration, congestive headache, dizzi- ness and tendency to syncope. The tincture of the sporules may be given when there is extreme sensitiveness of the surface; sensitiveness of a part, and care to prevent its being touched; slow, painful boils, nodes or swellings; extreme sensitiveness of the organs of special sense, with pale, livid or dirty complexion. MACROTYS RACEMOSA. CIMICIFUGA RACEMOSA. (BLACK COHOSH.) Prepare a tincture from the fresh root gathered in Sep- tember, using 3viij. to alcohol 76 per cent. Oj. Dose, from the fraction of a drop to ten drops. For years I have employed Macrotys as a specific in rheu- matism, and with excellent success. Not that it cures every case, for it does not; neither would we expect this, for this would be prescribing a remedy for a name. Rheumatism may consist of varied pathological conditions, though in all there is the special lesion of the nervous system, which char- acterizes the disease. In one case we find the indications for the use of an acid prominent, and this becomes a remedy for rheumatism. In another there are symptoms showing the need of alkalies, and they prove curative. MACROTYS. 175 Macrotys influences the nervous system directly, relieves rheumatic pain, when not the result of inflammation, and probably corrects the diseased condition (formation of lac- tic acid?) which gives origin to the local inflammatory pro- cess. Thus in the milder cases, where the disease has not localized itself as an inflammation, Macrotys is very speedy and certain in action. In rheumatic fever it is also positive in its action, and with the special sedatives gives excellent results. Where rheumatism has localized itself in an inflam- matory process, all the benefit we obtain from it is, that we remove the cause, and hence the reason for a long continu- ance of the inflammation. It is a remedy for all pain having a rheumatic character, and for this we prescribe it with the best results. Those cases which go under the name of rheumatic-neuralgia, are very speedily relieved by it. In some cases the pains of weeks' duration disappear in a single day. Whilst the continuance of the remedy will not unfrequently effect a cure in these cases, in many it will require the additional means necessary to give healthy functional activity to some organ or part es- pecially impaired. The Macrotys influences directly the reproductive organs. This influence seems to be wholly upon the nervous system, relieving irritation, irregular innervation, and strengthening normal functional activity. For this purpose it is unsur- passed by any agent of our materia medica, and is very largely used. Its influence is very marked in functional disease of the reproductive organs of women. Associated with pulsatilla it is specific in many cases of dysmenorrhoea; it should be given for three or four days before the expected period, and continued until the flow is free. In amenorrhoea it is also one of our most efficient agents. In rheumatism of the uterus, to relieve false pains, or the many unpleasant sensations attending pregnancy, it has no equal in the materia medica, and becomes a true partus preparator. Like all other direct remedies, it may be employed in any 176 SPECIFIC MEDICINES. } case, no matter what name the disease may have in our nos- ological classification, if the condition of the nervous system calls for it. The heavy, tensive, aching pains are sufficiently characteristic and need not be mistaken. So prominent is this indication for the remedy, in some cases (not rheumatic), that I give it with a certainty that the entire series of mor- bid processes will disappear under its use. I had a very marked example of this in severe typho-ma- larial fever. In one case, the disease had continued through the first week, growing worse daily under the treatment adopted, until the remarks of a night-watcher called my attention to these pains. Questioning elicited the fact that muscular pains had been severe from the first-but the pa- tient "thought it was part of the disease, and there was no use to complain." The treatment was changed from Vera- trum and the alkaline sulphites to Aconite and Macrotys, and the patient was convalescing in four days-there was marked relief in twelve hours. This will serve as an illustration of the fact, “that a cer- tain condition of disease may have that prominence in a case that an entire series of morbid phenomena will pass away when it is removed; or in other words, that a single rem- edy may prove curative when a disease is complex-removing the first in a series of morbid processes, the others disappear of themselves. MAGNESIA, SULPHITE OF. Sulphite of Magnesia was one of the anti-zymotic remedies recommended by Prof. Polli. We find in all that class of acute diseases which develop typhoid symptoms as they pro- gress, a need for remedies which control the septic process in the blood. Most physicians will have employed sulphite of soda in these cases, and have found marked advantage from its use, yet in other cases, presenting somewhat similar gen- eral symptoms it has done no good, and in some has done harm, MAGNESIA. 177 In We say that sulphite of soda is indicated where the tongue is broad, pallid, and covered with a pasty white coat. these cases it will rarely disappoint the practitioner. But we have need of the same antiseptic remedies in cases in which the tongue is deep-red or dusky, whether covered with a brown fur, or presenting the smooth glistening appear- ance noticed in some of the more severe cases of typhoid fever, or typhoid disease. Whenever the tongue is thus dark-red, we can not give the salt of soda, for there is pres- ent a prominent indication for the use of an acid. We may use sulphurous acid as the antiseptic, but frequently it is not well borne by the stomach. In these cases the sulphite of magnesia will be found an admirable remedy. We may say that it may always be ad- ministered when the tongue is dark-red, and shows a dark fur, and there is need for a remedy to antagonize the septic process in the blood. It is given in doses of grs. j. to grs. xx., repeated every three hours. MAGNOLIA. The Magnolia Glauca and Accuminata possess tonic and stomachic properties, which may prove useful in medicine. Will some of our Southern readers prepare a tincture from the recent bark, and test it thoroughly. It may not prove better than a dozen similar articles, and yet supply a very good medicine to those who live where it is abundant. It may be used in bronchial catarrh, gastric catarrh, rheu- matism, and in the convalescence from malarial fevers. MARRUBIUM VULGARE. (HOARHOUND.) Prepare a tincture from the fresh plant when in flower, using 3 viij. to alcohol 76 per cent. Oj. Dose, from gtt. j. to x. The Hoarhound exerts a marked influence upon the respi- ratory apparatus. It is stimulant to all mucous surfaces, but especially to the laryngeal and bronchial, and it may be em- 178 SPECIFIC MEDICINES. ployed for this purpose. But it evidently has an action be- yond this, and influences the function of respiration. Any one who has employed it will have seen this very marked in some cases. Let us have it thoroughly tried, and it may be another instance of a very valuable remedy in a common article. 1 MARUTA COTULA. (MAYWEED.) In testing these indigenous remedies, will some one pre- pare a tincture from the fresh Mayweed, and give it a thor- ough trial? The direction of the investigation will be shown by reference to the Dispensatory or Materia Medica. MANGANESII SULPHAS. (SULPHATE OF MANGANESE.) In doses of from one-fourth of a grain to one grain, the sulphate of manganese will be found a good remedy in dropsy (ascites) from disease of the liver, especially in those who have been hard drinkers. It may also be used in jaundice, with enlarged liver, the patient complaining of fullness and weight in the hypogastrium. A pale, leaden tongue, dirty, with full stomach, pendulous abdomen and sluggish bowels, is sometimes benefited by small doses of this remedy. A. first or second decimal trituration may be employed to very good advantage where tissues are old and feeble, the heart's action feeble, and the circulation of the blood weak. MELILOTUS OFFICINALIS. (SWEET CLOVER.) Prepare a tincture from the plant in flower, using alcohol of 98 per cent. The dose will range from the fraction of a drop to ten drops. It has given excellent results in the treatment of neural- gia, especially when associated with debility. It has cured cases of many years' standing. A strong indication for its use is a marked soreness and lameness, which follows the MERCURY. 179 attacks of pain. It may be administered in colic, painful diarrhoea, dysuria with painful desire to urinate, in dysmen- orrhoea associated with lameness in the hip, and along the course of the sciatic nerve, and in some cases of rheumatism where such lameness is a marked feature. MERCURY. Eclectics have always been opposed to the common use of mercury in the treatment of disease, because as commonly used it did very much more harm than good. In the United States it has been extensively employed in all the ills that flesh is heir to, and in all its preparations, from the one-twelfth of a grain of corrosive sublimate or protoiodide of mercury. to teaspoonful doses of calomel. The use of mercury to tap the liver, and touch the gums, and the fearful salivation and sore mouth that sometimes followed, the protracted sickness, the increased death-rate, and the lasting wrongs that were entailed by it, even when patients recovered, are all vividly in the minds of our people. In the light of to-day, it is no wonder that the Eclectic school of medicine opposed its use, and made such a vigorous fight against it for half a century, until even its advocates are obliged to use it secretly. The charges made against it have all been sustained, and respectable practitioners of medicine in the city use mercury very sparingly, if at all. In the country they still use it, and patients are still abused by it. The common use of mercury by the Homœopaths, though the dose is small, is to be dep- recated, as I have known much harm to result from it. Two of the worst cases of salivation I ever saw (resulting in death) were the result of Homœopathic treatment. And still, if rightly studied, mercury might fill a valuable place in medicine, but only in the treatment of chronic dis- But if one does not make up his mind that it is a dan- gerous agent, and must be carefully studied and very rarely used, it had better be left alone. ease. I have no hesitation in using calomel as a dry dressing in 180 SPECIFIC MEDICINES. chancroid or chancre, when the sores are pale and covered with a pultaceous secretion. In chronic eczema, and in sycosis and barbers' itch, and in some cases of pruritus, I employ the brown citrine ointment with advantage. In secondary syphilis, the tongue being small and of usual or more than usual redness, I use Donovan's Solution of Arsenie (containing a minute quantity of iodide of mercury). generally in combination with Phytolacca. Mercury in the usual doses should never be given when the tongue and mouth are pale; fauces, palate and tonsils pale and full; pale tongue, shiny red spots over it; increased secretion of saliva; full lips; pallid, expressionless face. In such cases it is eminently pernicious, and yet these are Ho- mœopathic indications for it. If I were giving it, the indications would be, a small tongue of natural redness, good color of lips, skin elastic. circula- tion good, urine of usual specific gravity, depositing no sedi- ment. It is well to have these facts clearly before us, whe- ther we administer a dose of mercury or not. MENYANTHES TRIFOLIATA. (MARSH TREFOIL.) A tincture is prepared from the fresh leaves, using alcohol of 98 per cent., the dose of which will vary from the fraction of a drop to ten drops. It will be found a useful tonic in impaired digestion and blood-making, associated with uterine disease and irregular- ity, and following quinine in malarial diseases. METHONICA GLORIOSA. A tincture is prepared from the fresh plant (a native of India) with alcohol of 98 per cent.; add gtt. x. to water Živ. and give in teaspoonful doses. It may be used when there is a sensation of burning and constriction in the throat, for impotency, spermatorrhoea, nervousness, hypochondriasis. MIMULUS. 181 MENISPERMUM CANADENSE. (YELLOW PARILLA.) The Yellow Parilla has been considerably employed for the indefinite purpose of an alterative. We have the testi- mony of the Dispensatory that: "In small doses, no obvious effects are produced on the general system." It may be worth while, however, to examine it further, and it will offer a good subject of study to some of our readers. For experiment prepare a tincture from the fresh root, 3 viij. to alcohol 76 per cent. Oj. Use it in doses of from gtt. j. to gtt. x. MENTHA VIRIDIS. (SPEARMINT. Preparation.-Prepare a tincture from the fresh herb, 3 viij. to alcohol 76 per cent. Oj. Dose from gtt. j. to gtt. xx. Mentha Viridis is not only a stimulant, but is one of the most kindly of the aromatics, and is rarely rejected by the stomach. As a stimulant, it will furnish a cheap and pleas- ant vehicle for many medicines. But it is more than this. I regard it as one of the most cer- tain of the vegetable diuretics, and employ it frequently for this purpose. In suppression of urine in children, a tea- spoonful of the tincture is added to two ounces of water, sweetened, and given freely. So certain is its action in child- hood, that I rarely think of giving anything else, except in cases where there is great irritation of the nervous system, and then Gelseminum is added to it in the usual doses. MIMULUS PILOSA. (MONKEY FLOWER.) This plant may be found growing in various sections of the country, but chiefly, as far as I know, in California. I have employed it topically, and with much success, in local inflam- mations, as rheumatism, neuralgia, erysipelas, burns, etc., in which cases the tincture may be used, or a cataplasm made 182 SPECIFIC MEDICINES. with the plant. I have likewise administered the remedy internally in rheumatic and neuralgic affections, with appa- rent benefit. A spray of the tincture made with dilute alco- hol has given me most excellent results in the treatment of obstinate bronchitis. My supply of the agent having been limited, I have not been able to test it as fully as could be desired, though I hope ere long to be furnished with a new and larger amount. Whether other varieties of Mimulus possess similar prop- erties, I can not say. The principal object of this commu- nication is to call the attention of our physicians to the plant, that they may thoroughly investigate its virtues. J. KING. MITCHELLA REPENS. (PARTRIDGEBERRY.) Preparation.-Prepare a tincture from the fresh plant, 3 viij. to alcohol 76 per cent. Oj. Dose from gtt. j. to 3ss. The Mitchella exerts a direct influence upon the reproduc- tive apparatus of the female, giving tone and improving func- tional activity. It has been extensively used as a uterine tonic, to promote menstruation, to remove false pains and unpleasant sensations in the latter months of pregnancy, and has been thought to be a good preparative to labor, rendering the birth of the child easier, and less liable to accidents. Many have failed to obtain these influences from the use of the common preparation, "Compound Syrup of Partridge- berry," because it was prepared from old materials. If made from the green plant, as named above, we think it will give satisfaction. MONOTROPA UNIFLORA. (ICE-PLANT.) Will some of our subscribers prepare a tincture from the Ice-plant, and test it in the cases named in the Dispensatory. We especially want to know its influence upon the nervous system, and its action as a sedative. It is claimed to be rem- edial in convulsions, epilepsy, chorea, etc. MURIATE OF AMMONIA. 183 MOMORDICA BALSAMINA. (BALSAM APPLE.) The Balsam Apple is an annual climbing plant, grown in our gardens for its fruit, which is employed in domestic practice as a vulnerary, and an application to old sores, piles, chapped hands, etc. It is commonly prepared for use with alcohol or whisky. It evidently possesses medicinal proper- ties, and I have seen good effects from its local use. • It is claimed to be poisonous when taken internally, yet I have known it taken with safety in doses of ten to thirty drops. Cures of dropsy are reported from its use. The limited use I have known made of it internally was to relieve muscular pains, lame back, and stiffness of joints. In some cases it seemed to do good. As the agent is very common, and easily cultivated, it would be well to prepare a tincture from the fresh fruit, 3 viij. to alcohol 76 per cent. Oj., and test it thoroughly, both as a local remedy and used inter- nally. Of such a preparation the dose would be quite small, say commencing with one drop. MONESIA. Solve the extract (imported from Brazil) in dilute alcohol, or in water, adding alcohol sufficient to preserve it. It may be used in doses of one to three drops. The Monesia is a mild stimulant and tonic, and may be given in atonic dyspepsia, in convalescence from the malarial fevers, in chronic diarrhoea, chronic bronchitis, and incipi- ent tuberculosis. MORPHIA. (See Papaver Somniferum.) MURIATE OF AMMONIA. "Muriate of Ammonia is one of those common-place and unattractive substances which we, in this country, are little apt to credit with extensive remedial properties in disease." We quote the first sentence of an eminently suggestive paper 184 SPECIFIC MEDICINES. by Dr. Anstie (The Practitioner, December, 1868), which The practice of medicine is proverbially uncertain, not so much possibly as regards the termination of disease, as regards the influence of medicine to palliate or arrest it. Instead of making this uncertainty a cardinal doctrine, a belief in which is absolutely essential to regularity, it seems to me it would be profitable to examine it carefully, and by analysis determine the "elements of uncertainty;" we might then hope to determine the "elements of certainty," and by a simple process of reasoning, avoid error and attain truth. The most important factor in "medical uncertainty," is un- doubtedly our present nosology. It is thought to be the chief end of medical study to attain such skill in diagnosis, that the diseases met with may be correctly classified, according to Good, Wood, Da Costa, or others And having thus affixed 284 SPECIFIC MEDICATION. a name by which they may be known, treat that name accord- ing to a Materia Medica which reads-" this remedy has been found useful in"—or "this remedy may be employed in,” etc. The element of uncertainty lies here, that a name employed to designate a disease, may cover the most diverse pathologi- cal states. The case of to-day, and the case of to-morrow, though justly called by the same name, may require a widely different treatment; the remedies employed successfully in one, would increase the disease in the other. Every one of our readers may draw the evidence of the truth of these propositions from his own practice. The second "element of uncertainty " we find in the doc- trine of idiosyncrasy, which is also a cardinal article of faith. We are gravely taught that in medicine one of nature's laws -that "like causes produce like effects," is inoperative; and, on the contrary, "that no man can possibly tell from the action of a medicine on one, what will be its influence upon another." The doctrine of idiosyncrasies is broad enough to cover all shortcomings and failures. And if true, then now and forever medicine will be a great uncertainty. The third "element of uncertainty" lies in the application of the Latin motto, post hoc ergo propter hoc-that which follows a medicine must be due to its influence. If a man recovers from sickness after taking Podophyllin or Quinine, it is due to these agents, and he probably would not have gotten well without them. But there is this singular fact here: whilst physicians are willing to credit their remedies with all relief from suffering, improvement and restoration to health, they are not willing to reverse it, and concede increase of suffering, prolongation of disease and death to the reme- dies, though the sequence is quite as natural in the one case as the other. It does seem strange that physicians should have so thor- oughly believed that medicine saved the lives of the sick, that without it the majority, or all, would have died. Strange that they never should have observed, until within the past score of years, that abundant provision might have been UNCERTAINTY IN MEDICINE. 285 made by the Creator for the removal of disease, and that it was possible that medicine might be adding to the death-rate, rather than lessening it. Even now when all this is proven beyond cavil, by some of the best observers, we find the majority won't believe it; even if they concede it in theory. they deny it in practice. The fourth element of uncertainty lies in the endeavor to get direct results from indirect agencies. You want to in- fluence the circulation and the temperature, and you give remedies which produce emesis or catharsis. You want to elect Greeley, and you whip your neighbor because he “rah's” for Grant. The fifth element of uncertainty is the administration of remedies in poisonous instead of medicinal doses. It is true that the poisonous action may be known with some certainty, but its influence upon disease is very uncertain. The poisonous action sets up a new process of disease in so far as it changes structure and function, and it may be cura- tive according to the law of substitution. A medicinal action we understand to be one that restores function, and thus removes disease. Give your remedy in medicinal doses, and then you may expect direct and positive results in the relief of disease. These are the principal elements of uncertainty in regular medicine and in our school. To these we might add a num- ber of minor ones, among which is a belief in "special providences," inscrutable or otherwise. Indeed any one who is inclined to shift his responsibility upon his Creator, and to believe that the laws of nature can be suspended from any providence, has all the elements of uncertainty with him. The principal element of uncertainty in Homœopathic medicine is the making of pain a principal symptom, and the treatment of symptoms in place of pathological conditions. The cheerful trust in Nature of the high dilutionist is lauda- ble, though we can't say so much for their claim to all the glory of relief and recovery 286 SPECIFIC MEDICATION. This is but a rough sketch of the subject, which we present as good material for thought. We purpose using it as a text in the future, and elaborating some of the points. In our next article, we will consider the "elements of certainty" in medicine, in the same order.-E. M. Journal, July, 1872. Elements of Certainty in Medicine. In our last article we briefly discussed the "elements of uncertainty in medicine," and we now propose to look at the other side-how may we attain certainty in medicine. We all agree that the practice of medicine in the past has been notoriously uncertain, and that there is yet great room fo. improvement. "" The first, and most important element of "uncertainty 18 found in our present nosology, and the constant tendency to prescribe for names of disease. The first "element of cer- tainty " will be, therefore, an entire avoidance of this error, diagnosing pathological conditions and prescribing for these. We have heretofore seen that disease, as we meet it in the individual, consists of a series of functional lesions-all dis- ease is an impairment of function. Certain prominent lesions. or symptoms give a name to the disease, according to the present nosology, but the name does not, and can not convey to the mind the character of the lesions or the treatment re- quired to remove them. If I say my patient has "pneumonia '' (taking one of the simplest diseases), I give you no informa- tion which would guide you to a correct treatment, and if you prescribe it must be upon the idea that all inflammations of the lung are alike, unless you follow the expectant plan, and use the "mush poultice," with rest and good nursing. In one case the prominent lesion would be of the circula- tion and temperature; and we would stop the inflammation by the third day with the use of Veratrum and the bath, alone. In another case with small pulse, and tendency to congestion, we would relieve our patient speedily with the use of Aconite and Belladonna, and the local application of CERTAINTY IN MEDICINE. 287 Compound Powder of Lobelia to the chest. In a third class of cases, with especial impairment and feebleness of mucous structure, Ipecac would be a prominent remedy. In a fourth class of cases, with special impairment of skin and dryness. of mucous membranes, we would use Asclepias. In a fifth, if we had the broad pallid tongue, we might treat the case with Bicarbonate of Soda alone. In a sixth, of typhoid character, we would obtain especial benefit from Sulphur- ous Acid, Muriatic Acid, Sulphite of Soda, or Baptisia. In a seventh class of cases, with hypochondriac fullness, umbilical pain, sallowness and puffiness of skin, yellowness about the mouth, and the coloring matter of bile in urine, I will cure every case with the single remedy, Nux Vomica. Eighth, all our readers know that there is a class of cases in which Quinine is eminently curative, and will alone speedily arrest the disease. Is it not most absurd, therefore, to talk about a stereotyped treatment of pneumonia? We have named eight classes of cases, and in the entire lot have wanted no remedy for the lungs. It really makes no difference whether it is an inflam- mation of the lungs or the nates, only in so much as a man breathes with the one and sits on the other. Specific diagnosis is therefore the first element of cer- tainty in medicine. We want to know the character of the lesion of the circulation, the temperature, the functions of digestion, nutrition, secretion and excretion. innervation, etc., and knowing these, and how remedies influence these func- tions, we prescribe with a reasonable degree of certainty. The second element of certainty is a firm reliance on nature's law—“ that like causes produce like effects." We are not looking for "idiosyncrasies" to excuse our ignorance, or “special or inscrutable providences" to cover our defects and shortcomings. We want to study those symptoms and signs that determine exact conditions of disease, and then knowing the action of remedies we may always give them with certainty. The third element of uncertainty we found to be the taking 288 SPECIFIC MEDICATION. of every good result that followed the administration of remedy, as being due to its action. This must be carefully avoided. We study the direct or specific action of remedies by using them singly, and observing the consequences in numerous cases; it is confessedly a work of time, and a work of difficulty, but it can be done. The fourth element of certainty is found in giving reme- dies for their direct effects, and not as they produce counter- irritation or some other disease. If the circulation is wrong, wo give a remedy that acts directly upon the circulatory sys- tem, and in such way that the wrong may be righted. If there is a lesion of the blood, we give a remedy that reaches the blood and antagonizes the lesion. If the skin, kidneys or bowels fail to do their work of excretion, we reach them by remedies that exert their influence directly, and so of the entire Materia Medica. The fifth element of certainty consists in the use of reme- dies in medicinal doses and for their direct curative influence. No man can tell what influence an active cathartic will have upon a frequent circulation, any more than he can tell what the influence of a blister will be in pneumonia. The course of a medicinal disease is notoriously uncertain, as is ex- ampled by the use of mercurials. A sixth element of certainty, and a very important one is- that we have reliable medicines. If we are to take our reme- dies "hit or miss" from the drug trade, our practice will be "hit or miss." The drugs of the market are notoriously uncertain. We want our indigenous remedies gathered at the proper season, and prepared for use from the fresh or recent articles. The best form is a fluid preparation, of the strength of eight ounces Troy to the pint of product. This can be kept from season to season, is uniform in strength, easily dis- pensed, pleasant on account of smallness of dose, and relia- ble in its action. Without uniformly good preparations, the practice of medicine must be uncertain, and there will be a constant tendency to gross medication and drugging.—E. M. Journal, August, 1872. DOCTRINE OF SUBSTITUTION. 289 The Doctrine of Substitution. In the olden time the doctrine of substitution was a prom- inent feature with some Eclectics. They could see no need of any change in the commonly received doctrine of the Old School, and they were firm believers in phlogosis and anti- phlogistics. Blood-letting, Mercury and Antimony, etc., were an offence to them-not because of their general depres- sant influence, but because they were thought to be unman- ageable, or exerted some special or permanent pernicious in- fluence When the writer attended his lectures, this doctrine of substitution was prominently brought forward, and lecturers would labor to show that we had substitutes for the old means, quite as effectual at the time, but transient in action. There were a number of substitutes for bloodletting. Prof. Buchanan spent much time in showing how hemastasis could be employed, even to the extent of syncope in active inflam- mation, and when we had obtained the desired influence, the blood could be gradually let back from the corded limbs into the general circulation, and thus whilst we had obtained the antiphlogistic influence of bloodletting in the relief of inflam- mation, we had saved the vital fluid. "The boy had eaten his cake and saved it.” Profs. Jones and Morrow believed that all the good effects of bloodletting could be obtained by vigorous cathartics; that in this free catharsis the bloodvessels could be depleted almost as quickly, and to a far greater extent, whilst the vital portions of the blood were saved, and the serum would be quickly renewed. Prof. Cleveland and some others thought that this influence could be obtained by the kidneys as well as the bowels, and that the two at least were equal to bloodletting. Whilst in addition, you would be promoting the removal of large quan- tities of effete material. Mercury, in the form of Blue-pill, Calomel, etc., was the 25 290 SPECIFIC MEDICATION. Samson of regular practice, acting on the liver and thus re- moving disease. We must have a substitute for this Samson, for we too must "touch the liver" of our patients. And it was claimed that in Podophyllum and Podophyllin we had a greater than Samson, or if we wanted the certain but mild action on the liver-like blue-pill-we would use Leptandra or Leptandrin. But we must "tap the liver," and thus we could do it safely. "" But these would not 66 touch the gums," and as our oppo- nents regarded "touching the gums as essential to the suc- cessful treatment of some diseases, we must find a substitute for Mercury in this direction, and touch the gums too. For this purpose Iris was recommended, or equal parts of Iridin, Podophyllin and Xanthoxylum, given in grain doses every hour or two. And we are told "that salivation from vege- table agents may be known from that by Mercury, by the ab- sence of mercurial fetor, and no sponginess of the gums or loosening of the teeth." And that when Eclectics, from hav- ing produced such salivation, are unjustly accused of using Mercury, they may excuse themselves by calling attention to the above differences. The necessity of vigorous counter-irritation by gut and skin was recognized, and many similar means were employed to obtain it. "Profound impression," by active cathartics, was required in the treatment of many diseases, and for this pur- pose we would take Gamboge, Scammony, Colocynth, etc., and make the combination Eclectic by adding Podophyllum or other indigenous remedy. We must use the blister, and Cantharides being the only certain agent, at least the only one that could be handled with safety, we take it. But as it would not do to go too far in this direction, we substituted for the Tartar Emetic ointment, a vegetable irritating plaster. Nauseant expectorants must be used in diseases of the re- spiratory organs, and we substituted for Tartar Emetic, Lobelia and Sanguinaria, but we still retained Ipecac. Stim- ulant expectorants must be used, and we kept Squills, Senega. Tolu, etc., because we had none better, and thus the doctrine DOCTRINE OF SUBSTITUTION, 291 of substitution ramified in every direction, and in some cases it would be so slight that there would be no real difference. Was this Eclecticism? Do you think it possible that a School of Medicine, increasing for thirty years, could be founded on so small a basis? These were errors that grew out of a want of a well defined statement of principles, and especially a want of knowledge on the part of some teachers. There was a profound conviction that the old depressant practice was wholly wrong, and that in its stead treatment should be restorative. So that really whilst substitution was thus freely talked of, entirely different means were employed. Just in proportion as the practitioner departed from the old ideas and methods, and employed restorative means, just in that proportion he was successful. But it was not only the rejection of the antiphlogistic plan, and the recognition of Nature in the cure of disease, that gave impetus to the Eclectic movement. But beyond this, and fully as important was the introduction of new remedies, for their direct action in opposing and removing disease. Take the Medical Reformer in its five volumes, and all our earlier medical publications, and you will find a large list of remedies that had been carefully studied, and the use of which gave great success in practice. These earlier Eclectics taught Specific Medication as certainly as has Dr. Scudder, though they did not use the name. And what is more, they obtained just the same influences from many of them that he has, and they describe this action in just the same way. It need hardly be added, that those earlier publications of our School, have been a mine of information which the writer has worked advantageously for the past dozen years. This doctrine of substitution has been the bane of our School, constantly drawing us backwards. We want none of it. We do not believe the old doctrines of disease, we want no antiphlogistic or depressant treatment in any case. Eclectic medicine looks to the conservation of vital power, is restorative, and so far as possible advocates specific medicines for specific pathological conditions.-E. M. J., June, 1871 292 SPECIFIC MEDICATION. Poison vs. Medicine. As we have stated, "almost all drugs have two actions— 8 poisonous and a medicinal. We want to avoid the one and obtain the other." How shall we study the Materia Medica to obtain this desirable end? At first thought it would seem that the difference between the poisonous and medicinal action was wholly one of dose. If I administer two grains of Strychnia I give a poison, if the one-thirtieth of a grain it favors life; if I give five grains of Morphia the patient dies, if but one-third of a grain he has refreshing sleep. You can kill a man with large doses of Podophyllin, Lobelia, Jalap, and a hundred agents of like character, when small doses would not kill, and might be medicinal. But this is only partly true. The dose may be large enough to be poisonous, and then the size of the dose will be the only element of danger, but there is another consideration of more importance. Those agencies that we call remedies exert an action upon the body, and change one or more of its functional activities. If we give a drug to a healthy person, it produces disease, and it is because it thus acts upon the body that it becomes a remedy-an agent that had no such action would be useless. To make this agent a remedy, however, it is essential that there should be a functional wrong of the part upon which this agent acts, and that its action opposes the wrong of dis- ease, and favors the return to health. If now we mistake, and give a medicine to influence a functional wrong that does not exist, then we are poisoning our patient-it may be slowly, but the influence is neverthe- less poisonous. To illustrate, we find a condition of the system in some malarious diseases in which Quinine is tolerated in large doses, and is curative. We give a dose of twenty grains in congestive remittent with the happiest results, because the POISON VS. MEDICINE. 293 remedy is antagonized by the disease; but under different cir- cumstances the patient would suffer seriously. We find cases in which patients can take large doses of the Bromides with safety and benefit for a long time, but in others the remedies are poisonous in moderate doses. I have seen serious results from the use of Iodide of Potassium for a long time, as I have from other remedies given by rote. I have been censured for giving Copper as a remedy, be- cause it was a poison. And yet we find pickles greened with Copper as an article of food on many tables for years. My use of Copper has been attended with the happiest resul's, and I use it with quite as clear a conscience as I use Iron, but I only use it when Copper is wanted. I have been censured for the use of Bismuth, because it is not a constituent of the body, and yet I have never seen the harm following this agent, that I have from Podophyllin. It has been clearly demonstrated within the past two years, that Phosphorus and Arsenic are very closely related chemi- cally and medicinally. That Phosphorus exerts a very similar influence upon the skin, and may be used in place of Arsenic in skin diseases. Yet Phosphorus as Phosphorus is by far the most difficult to use, the most unmanageable, and the most likely to poison the patient, yet none of these rabid Eclectics object to the use of Phosphorus? Why do I object to the use of Mercury? Because its in- fluence is to impair the vitality of the body It is destructive in its nature-and I want no remedies of this character. ] object to the use of Antimony upon the same grounds, to the use of the lancet, the blister, harsh purgation, the entire class of antiphlogistics, from what ever source obtained. I base my objections upon principle, and not because there is a prejudice against these things. If I believed in the necessity of antiphlogistics, as some do, I should employ bloodletting and Mercury as the principal means, because they are the typical antiphlogistics, and will destroy life faster than any thing else.-E. M. Journal, August, 1872. 194 SPECIFIC MEDICATION. Treatment of Disease with a Single Remedy. The perfection of specific medicine is found in those cases, in which the entire series of functional lesions is removea by one drug. Possibly medicine will never attain such per- fection; it is possible we have quite as much knowledge now as we ever will have, but as we have some marked examples of this, it is reasonable to conclude that time will develop more. In studying the specific action of Tinctura Ferri Chloridi we found some singular but well attested facts. We found that this remedy was specific in a majority of cases of erysipelas, and that in many of these its action could not be accounted for by the older therapeutic doctrines. Here is a disease presenting all the functional lesions of the severest zymotic fever. A hot, dry skin, temperature of 106°, pulse 120 per minute, small and hard, mouth dry and parched, tongue brown, sordes on teeth, delirium, and an unpleasant local inflammation constantly spreading. We commence the administration of Tincture of Muriate of Iron in doses of ten drops. Before the second dose the effect is noticed, and within twenty-four hours, the pulse has fallen and become more natural, the temperature is reduced, the skin is soft and moist, the delirium has passed away, the patient has slept and is conscious, the mouth is moist, tongue cleaning, and the local inflammatory process arrested. In a few days the patient is convalescent, and yet but a single remedy has been given. It has been sedative, diaphoretic, diuretic, a nervine and an antizymotic, and a more efficient one than any that could be selected from the Materia Medica. Every one of our readers knows these facts with regard to Iron, in the treatment of some cases of this disease. Is Iron in erysipelas an anomaly in therapeutics, the one exception to all general rules? Let us take Quinine as another example, and I will try to give a case that the majority of my readers have seen-one of A SINGLE REMEDY. 295 malarial pneumonia. The patient was attacked with a severe chill, followed by fever, increasing from day to day. There was at first an irritative cough, followed by soreness of chest, difficult breathing, rusty sputa, and the usual physical signs. Severe from the commencement, it was only aggravated by the expectorants ad nauseam, the cathartics, blister, and associate means. Now the ninth day of the disease there is purulent expectoration, great prostration, and the evidences of early dissolution. Doctors are changed, and the new one recognizes it as a case for Quinia. There is relief from the first dose, and a rapid amendment and convalescence in a few days. I name this case, because it is one I have seen within the last few weeks, but the reader can recall many cases of a similar kind. Here Quinine has been everything that is good, sedative, diaphoretic, diuretic, stimulant, tonic, a remedy for the lungs, the one thing necessary. I have just completed the treatment of one of the severest cases of carditis, associated with inflammation of the posterior portion of the lung, that I have ever met with, in which the action of Quinine at a certain stage was quite as marked. The patient had been under regular treatment, with consult- ations for eight days, when he came into my hands. There was disturbance of the bowels, demanding special treatment, an unpleasant circulation, effusion into the pericardium, and delirium, all of which seemed to demand something. By the end of the week, I saw the place for Quinine, and with four doses of a grain each, daily, and small doses of Cactus, all the symptoms rapidly faded away. It relieved the delirium, gave sleep, quieted the cough, brought the pulse down and gave it regularity, established secretion, and did all that was necessary. And I may state this important fact, the patient was not convalescing when it was commenced, but had had a severe relapse. Now I would hardly undertake to point out the symptoms that caused me to give the Quinine in this case. There was no malarial poison, nothing seemingly for it to antidote, but there was an impairment of the nervous system for which it 296 SPECIFIC MEDICATION. was the remedy. I admit that I should be able to point out the symptoms so that another could recognize the case, and tell why I give Quinine in certain cases, as in the one above, but I can't as yet. We will sometimes find quite as marked examples in the administration of Nux Vomica. I recall a case in the past year of severe fever at the fifth day, not controlled in the least by the sedatives and associate means. A peculiar yellowness about mouth, umbilical pains, with increasing nausea, caused me to give Nux Vomica. The prescription was: R Tinct. Nux Vomica, gtts. v.; Water, 3iv.; a tea- spoonful every hour. The next morning there was a decided amelioration in all the symptoms, and by the seventh day the patient was convalescent. So I have treated inflammation of the lungs, fever, dysentery, colic, diarrhoea, and many other named diseases, with Nux alone, the symptoms pointing to it distinctly, and with the most satisfactory results. Doubtless, most of our readers have noticed a peculiarity of pulse, to which Aconite is the remedy. And with Aconite alone have been able to treat the entire disease with more than ordinary success. Given the small pulse, with moderate hardness, and a singular vibration like a violin, string under the finger, and we have as near as I can give it the indication. To be plain, I say give Aconite always when the pulse is small and frequent, but sometimes it is only one of a number of remedies necessary, but in some it is all. Now let us learn to know those cases in which it is all, and then we will obtain the same results as we see from Quinine when it is specific. There is a eondition of disease to which Baptisia is specific in the same way. My first experience with this was in the Winter of 1859, in an endemic of cynanche maligna. In some of these cases the symptoms were as grave as in typhoid fever, and the ordinary treatment was not a success. Yet Baptisia controlled the frequency of pulse, lessened the temperature, established secretion, restored digestion, antidoted the rapid sepsis, and controlled the local disease. I have given it in three cases of typhoid fever with like results. There were A SINGLE REMEDY. 297 characteristic symptoms indicating the use of the remedy, and when given it checked irritation of the bowels, lessened the fever, stopped the progress of sepis-indeed, did all for the patients that the most sanguine could have asked. I have used it in one case of dysentery (alone) with ike results. Some of our Homoeopathic friends up North give their testi- mony in its favor, giving a large number of cases like the above, so that it has not been a single experience. And I find on reading back, that Eclectics had similar results twenty- five years since. We can reach but one conclusion from this, and that is, that there is a condition of disease to which Baptisia is spe- cific, and when this condition is the basis of the series of morbid processes that make the disease before us, it may be the one remedy for the totality of disease. I have been guided by two symptoms, the peculiar fullness and purplish discoloration of fauces and pharynx, and the papescent, frothy, dark-colored feces. That there are others, I doubt not, and probably some more positive, but these would cause me to give Baptisia in any case I have seen the gravest forrs of disease rapidly fade away, upon the administration of Bi-carbonate of Soda when the common means had failed. There was a special indication for it; any one might see it, if he knew how and where to look. And now simple Soda becomes sedative where seda- tives had failed, gives sleep where Opium had failed, estab- lishes secretion, antidotes the blood-poison, or is actually antiperiodic where Quinine has proven a failure. In evidence I may cite Prof. King, who gave me my first instruction in this, and might add hundreds of others. If we wanted evidence badly, I might bring forward Chambers, Anstie, Bennett, Wunderlich, and others, to prove that very similar results have been obtained from the use of Muriatic Acid. With it alone, hundreds, yes, thousands of cases of typhoid and typhus fever have been treated, with a mortality ranging from less than one per cent. to never more than three. There was something special in these diseases 298 SPECIFIC MEDICATION. that the Acid met, and it was the one thing necessary, every- We have learned to determine this condi- thing necessary. tion and we use Acids in a rational way. I might give other examples, but these will suffice to awaken attention, and all that the subject wants is thought and investigation. There is here a broad field for study, and one that should well repay research. That medicine will ever reach such perfection, that we will be able to select one remedy for the totality of disease in all cases, I do not believe, but that it may be done in a considerable number, I am quite certain.-E. M. Journal, June, 1872. Pleasant Medicines. The great desideratum in the practice of medicine is pleasant remedies. In the olden times, and with many now, medicine adds to the sufferings of the sick, and they dread more the unpleasantness of the doctor's prescriptions than they do the disease. In looking over our Materia Medicas and Dispensatories, it would seem that our object has been to make the concoc- tions as nauseous as possible. In extemporaneous prescrip- tions it is the same; the combination of remedies, and the vehicle, combine to make the mixture unpleasant It has been thought that sugar or syrup would cover up the unpleasantness of medicine, and hence it is most commonly used. The fact is, however, that with the majority of the sick the sweet is unpleasant, and nothing could be more ob- jectionable than a nauseous sweet. The doctor don't take his own medicines, and hence he does not know how objec- tionable they are, and he continues giving these unpleasant mixtures year after year, to the detriment of his patient, and his own pocket. Let us first get rid of the idea that medicines should be and can be disguised. It never had one atom of truth in it, and a very little experimentation will determine its falsity. Take anything that is unpleasant, and the more you disguise PLEASANT MEDICINES. 299 it the worse it is. Some medicines are very objectionable in their taste, but they are less disgusting to the patient alone, than when mixed with syrup or other vehicle. The best form of vegetable remedies is a simple tincture by percolation: the best form for all remedies, if possible, is the fluid form. It is not only the best as regards the medicinal action of the remedy, but is also the pleasantest as well. The best vehicle for the administration of a remedy, is water, and it also is the pleasantest. But few remedies are intended to exert a local influence upon the mucous coat of the stomach. All others must first gain entrance to the cir- culation, before their curative action can be obtained. To get into the blood by osmose, it is necessary that the agent be in solution, and of less specific gravity than the blood. If you do not have your remedy in solution before its adminis- tration, its getting into the circulation will depend upon the stomach supplying the necessary amount of fluid and effecting the solution. To the sick, there are but few of our remedies objectiona- ble, if they are properly prepared with alcoho! and given with water. The dose of properly prepared remedies is quite small, so that, added to fresh water in such proportion that the dose will be a teaspoonful, it is much diluted. Even if the taste is objectionable, there is evidence of cleanliness, and nothing to disgust. For years, I have made my prescriptions in one way-to a glass of fresh water adding the necessary amount of tincture or fluid medicine to make the dose a teaspoonful. In acute diseases the dose should be frequently repeated, hence it is necessarily small. Of a strong tincture of Aconite or Vera- trum, gtts. v. to gtts. xx. to 3iv.; of Gelseminum, 3j. to Živ.; of Macrotys, Asclepias, Lobelia, etc., 3j. to 3iv. As a rule, these doses exert a more marked curative effect than the larger ones commonly given. But it is in the treatment of children that unpleasant medicine is most objectionable. It is not pleasant to see the ittle ones start with distrust when the doctor makes his 300 SPECIFIC MEDICATION. appearance, nor to be obliged to force medicines upon a child. We get along much better if we have the confidence of the children, and it is certainly much pleasanter. I always prepare the medicines before my little patients. They see the water is fresh, their medicine looks clean and nice, whilst its quantity is small, and the mixture does not look objectionable. They taste it when asked, taking the first dose from the doctor, and give their opinion decidedly that it is good, (or at least not bad), and after this they take it kindly as the hour comes around.-E. M. Journal, Jan- uary, 1871. Conservation of Life. It is fortunate for mankind that we have life enough to resist processes of disease, and the medicaments of the doctor. This power of resistance, and vital tenacity, is really one of the most wonderful facts of our existence, and should be an admirable argument in the hand of the theologian to prove the fore-knowledge of the Creator It is the salvation of physic-for if it were not for this strong tenacity, doctors would soon bury all their patrons, and have to seek other means of livelihood. In some seasons, we have this subject forced upon ou attention in a way that we can not avoid it, and we are obliged to learn a lesson whether we will or no. As an example. some physicians have learned this season, for the first time, that Quinine will not cure all cases of ague, and that it wil act as a poison, leaving effects that are never recovered from So many learn the necessity of conserving the life, carefully guarding the feeble flame, and strengtening it, from some endemic or epidemic disease of an asthenic character which they see for the first time. The experience comes to some with dysentery, in others with inflammation of the lungs, typhoid fever, or even in the ordinary "bilious" fevers of our country. One lesson is sufficient for many, but the most of us require more; but when we have these experiences, and CONSERVATION OF LIFE. 801 the fact is forced on our attention, our practice undergoes a change, and we become very conservative. This experience has come to a great many this year, and we hear of it constantly in letters coming to our office. To many it has come through the typho-malarial fever so prevalent this fall, in which even the simplest depressants-purgatives for instance-have been sufficient to produce death. I give an instance from my own practice as an example-the only fatal case out of seventeen cases of this severe fever: Was called to see patient who had been sick with this fever for fifteen days, "given up" by the attending physician, and was not expected to live out the twenty-four hours. Careful attention, conserving life, was followed by recovery, though it required five more weeks. In the second week of my attendance, two more children took the disease, and though I did my best, the fever would run its course, and presently I was satisfied with holding my own-conserving life, in their cases. Both were convalescent the fourth week. But in the meanwhile a fourth child took the fever, not worse than the others, seemingly stouter, and having more vital tenacity. The sick in that house were getting too thick, and I concluded that in at least one of the cases I ought to stop the disease with medicine. The tongue was fearfully dirty, abdomen tumid, and I concluded to cleanse the prima via with a cathartic-the child was dead in three days. Instead of cleansing the "way of life," I wiped it out. There was no other reason why the boy should not have lived as did his brothers and sister, and he would have lived, in all proba- bility, if he had had the same treatment. It is not pleasant to sit in judgment on oneself, but I have found it profitable. I know there is no mean between good and harm in medicine as we use it; it will do one or the other—if it does not oppose disease, it opposes life. I know this talk about idiosyncrasy is all bosh, and when a medicine does harm, I am to blame, not the patient; and I try to learn a lesson from it, and not to fall into the same error again.- E. M. Journal, December, 1871. 302 SPECIFIC MEDICATION. On the Use of Restoratives. In order that the body may properly perform its functions it is necessary that there shall be normal nutrition of tissue Life grows out of the continued change of matter, and it is active and healthy in proportion to the decomposition and recomposition of tissue The food taken each twenty-four hours represents the force required and used in its organization, and used in the human body this force is set free as needed, and is living force. Just as in the wood burned under the steam-boiler, there is locked up the force required for its organization, derived from the sun, and which in the process of burning is set free, and manifests itself to us in the steam engine as power. If from any cause we have an impairment of nutrition, we must have an impairment of life in the same proportion. manifesting itself in simple deficiency of function, or in its perversion. Certainly in any such case the restoration of normal nutri- tion is one of the most important indications of treatment. And in the majority, we will find that as we approximate normal nutrition, we return to the condition of health. If we have an impairment of nutrition, what shall we do? You answer-give bitter tonics and iron. But experience proves that this is not always good practice, and if we would think for a moment we would see that it is very unphilosophi- cal. Bitter tonics are mostly gastric stimulants, increasing the appetite and to a limited extent gastric digestion. Iron is required for the building of red-globules. This it will be noticed is but a small part of what we have to take into cou sideration In studying nutrition and its derangements, we have to consider: 1st. The food, that it is good, properly propor- tioned between the histogenetic and calorifacient, and that it contains all the elements of the tissues in proper proportion and in such form that it can be appropriated. 2d. That the PAIN AND ITS TREATMENT. 303 action of digestion-buccal, stomachic and intestinal-shall be properly performed. 3d. That the blood is free from effete material, in regular circulation, and the associate blood- making organs are working w 11. 4th. The material being properly prepared, and taken to the part, that the part itself is in condition to appropriate it. (a.) That the old tissues are removed. (b.) That the formative force is sufficient for cell reproduction. We see that the lesion of nutrition may be dependent upor a wrong in the food; upon a lesion of digestion-either buccal, gastric, or intestinal; upon effete material in the blood; upon an impairment of the circulation; upon a defi- ciency of formative force in the cells of the part; or upon a defect of waste, the old tissues not being broken down and carried away. It may be rectified by selecting proper food, by such ele- mental substances as are necessary to nutrition, or by getting good mastication and insalivation, or by those agents which facilitate gastric digestion, or by those which facilitate intes- tinal digestion, or by those which remove effete material from the blood, or by those which favor an equal and uniform cir- culation of the blood, or by those which stimulate the forma- tive act in the tissues, or by those which aid the process of retrograde metamorphosis-removing the old tissues.-E. M. Journal, April, 1871. Pain and its Treatment. What is health? That condition of body in which all functions are a source of pleasure. What must then be the condition when the performance of function, or simple exist- ence, is unpleasant? Disease. We say a person suffers from disease, and the language of the people correctly expresses the fact-disease is a condition of suffering, or suffering is a con- dition of disease. If people did not suffer in disease, they would think very much less of it than they do, and might bear the confinement with considerable equanimity. We ask the question, again—What influence has the ordi- 804 SPECIFIC MEDICATION. nary practice of medicine upon the unpleasantness of disease that we call suffering? Let us think for a moment, before answering this question, and see if we can call up a past ex- perience in our own bodies to aid in solving the question. How is it with Castor Oil, Jalap and Senna, Podophyllin, a pint of Polygonum Punctatum or Eupatorium, a nauseant of Lobelia, Ipecac, Sanguinaria, et id omne genus? In the ordinary use of medicines do we increase the unpleasantness of disease? In the olden time this was thought necessary to save life, but we now know that this was a professsonal fiction, and that instead of saving life, mortality was increased by this use of medicines. Unpleasantness and suffering are evidences of disease-impairment of life-increase these by medicines, and you increase the sum of disease, and still further impair life. We conclude from this that a correct practice of medicine should be pleasant in itself, and that it should look to remov- ing unpleasantness and suffering, for these are evidences of disease. Admitting that it is still necessary to produce a temporary increase of suffering, to remove the cause of a more prolonged suffering, as when we give an emetic, or a cathartic of Podo- phyllin, we want to restrict these necessities as much as possi- ble, and finally get rid of them if we can. But there are times when the suffering in disease becomes unbearable, the patient must have rest and relief from pain, and for this purpose we are presented with certain drugs which obtund sensibility-called narcotics. Really, these consist of Opium and its salts, and the new agent, Hydro- chloral. So great is the seeming necessity for these, that the imports of the first amount to some millions of dollars yearly, and the second is weighed by tons. They are în such common use, and regarded as so indispensable, that we find them on every physician's shelves, and in every pocket case and pill- bags, and prescribed on every page of a druggist's prescrip- tion-book. PAIN AND ITS TREATMENT. 805 To these remedies, and to this common use I object, and I propose to give these objections "form and comeliness," and if possible present a better way. I object to the ordinary use of narcotics, because they are prescribed for symptoms and not for conditions of disease. It is well known by all who have studied modern pathology, that pain and sleeplessness may be due to two distinct and opposite conditions of the brain. In the one case the condi- tion is active-irritation and determination of blood. In the other, the condition is one of atony-the circulation and nutrition being enfeebled. Clearly these two conditions re- quire different treatment-for which will you prescribe Opium? and what will you do for the other? You find your patient alike sleepless in these two opposite conditions. In one the skin is dry and harsh, temperature high, pulse frequent and hard, secretions arrested. In the other the pulse is small and feeble, the face pallid, and the extremities cold. In which of these cases will you give Opium? and what will you do for the other? You find severe pain in a part, the patient wants relief, must have rest; did it ever suggest itself to you that it was worth while to take into consideration the condition of the part-whether it was one of activity or atony, or the general conditions as named above? In the ordinary use of narcotics these things are not considered, and hence the common use of these drugs is the worst form of empiricism. I have nothing to say about the uncertainty of their action, and the ill effects so frequently following their use. Every reader has had these experiences, and I have no doubt, would be only too glad to know how to get along without them, or learn to use them with greater certainty. I recognize the fact that there are two factors in this prob- lem of unpleasantness-pain, sleeplessness. The one is the general condition of the body, embracing every function; the other is the condition of the brain and its sensitive nerves. And I formulize it in this way. As is the departure from the normal standard of health in function and condition, so will 26 306 SPECIFIC MEDICATION. be the unpleasantness, pain, sleeplessness. Conversely, when we have either of these, we may expect relief just in propor· tion as we restore the body to its normal condition, and the brain to its normal condition. Thus, when my patient is suffering, or sleepless, I deter- mine as near as may be, what derangement of function is the cause, and instead of prescribing narcotics, I adopt those means that restore the diseased function. If the condition is one of irritation and determination of blood to the brain, relief and sleep come from the use of the sedatives and Gelseminum. If the condition is one of atony, it comes from the use of stimulants, tonics, and food. Prescribing for the basic element of disease, is a very cer- tain way of relieving pain and giving sleep. You will get those results from the simple administration of Bicarbonate of Soda, Muriatic Acid, Sulphuric Acid, Baptisia, Phytolacca, when these are specially indicated, as well as from the use of remedies that more especially influence the nervous system. Hoping that I have at least placed this subject in such light that our readers can think of it, and solve the problem for themselves, we will leave it for this time. I may remark, in conclusion, that I have not given a narcotic in eighteen months, and have not used the equivalent of a drachm of Morphia in five years.-E. M. Journal, April, 1872. Diagnosis and Treatment of Obscure Cases. We all have our troublesome cases, in which the symptoms are not pronounced, and the diagnosis is obscure, and the treatment being guess-work, proves a failure. The best men may make mistakes in diagnosis, but it should be of rare occurrence, and never one that will lead to the improper ad- ministration of medicine. Let us take a single condition of the intestinal canal as aL example. We are sent for to see a patient, and find him con- fined to room or bed, and complaining of inaction of the bowels. Question him as you will, the end is the same-con OBSCURE CASES. 807 stipation and he feels certain if his bowels are moved, all will be well. Will we give him a physic? And continue to repeat it, increasing its strength? Not by any means. We e sce in constipation but a symptom and not one especially indicating the character of the disease. It might be the disease called "bilious colic." I have seen it with a very moderate amount of pain; and though Com- pound Powder of Jalap, in broken doses, would prove cura- tive, Podophyllin and the harsher cathartics would kill. It might be acute enteritis, and then the dry skin, small, hard pulse, white narrow tongue, tenderness on deep pressure, would determine the character of the disease; and we would not give a cathartic under any circumstances. Again it might be hernia some of the obscurer forms, or ileus-invagina- tion, in either case, a cathartic would be the worst medicine we could give. In the above cases the constipation seems to be the direct symptom, if it is not the disease itself. So in many other cases, the symptoms that seem to point out the disease, are quite as likely to lead to wrong as right treatment. Supposing we take pain in the bowels-colic, as another example. It won't do, to depend upon the character of the pain always, to tell us the lesion or the proper remedy-and it don't do to call it colic, and prescribe at random. As an example, I was called to see a case that had been under the care of a Homœopath, who prescribed for the character of the pain; but the woman had suffered intensely for hours, and was exhausted by the severity of the pain. The inhalation of Chloroform for ten minutes gave entire relief, and there was no return of pain-there was intestinal spasm. Another: I had prescribed for a case of abdominal pain, in the early part of my practice, the usual routine of aromatics, stimu- lants, chloroform by mouth, winding up with Compound Powder of Jalap, until the stomach refused to tolerate any more medicine-and all without relief. A Homœopathic practitioner was called, and prescribing Nux Vomica alone, had the patient comfortable in three or four hours. I might 308 SPECIFIC MEDICATION. have done it, as well as he, if I had known then what I know now. The peculiar yellowness around mouth, sense of full- ness and oppression in right hypochondrium, and pain point- ing at umbilicus, told the story clearly. I recollect a case of green apples in my boyhood, and the drenching with Com position and diluted No. 6, as prescribed by a disciple of The suffering becom- Samuel Thomson, but without relief. ing fearful, and life endangered, the old Dr. was sent for, and a grain of Tartar Emetic relieved the stomach, and the boy was asleep in an hour. So I have had cases which were speedily relieved by small doses of Sulphate of Magnesia, or Iodide of Potassium-lead colic. So we will find cases, re- quiring an absorbent like Charcoal, an Alkali, Ammonia, Chloroform, Aromatics, even Podophyllin. And again we reach the concluslon that the pain was not the disease, not even a reliable symptom. Thus, in almost every case we are obliged to look beneath the surface symptoms, and use our reasoning powers, compar- ing the evidences of disease, and thus determining the exact functional lesions. Unless, and here is an important proviso, we have studied this subject of basic symptoms; then in a number of cases, no matter what the disease, the remedy will be indicated by a characteristic symptom. In this I agree with some Homœo- paths, as I agree that when a drug is thus clearly indicated, it will probably be the remedy for the totality of the disease. There is this difficulty here in some cases there is no char- acteristic symptom, or if there is we have not learned to know it, or have not learned the remedy. But the cases given, though illustrating the necessity of care in diagnosis, and the danger of falling into error, do not otherwise bear upon our subject. These cases are not obscure if ordinary care is used, for the evidences of disease are un- mistakable. We have cases, however, in which great care is necessary, and our diagnosis must be direct, differential, and by exclusion. Probably the shortest road to a correct idea of the methods OBSCURE CASES. 309 of diagnosis in the treatment of obscure cases, will be found in the following brief statement of the three methods above named: 1st. We have direct symptoms pointing to the seat, and the character of the disease. In simple cases these symptoms are clear and distinctive; in obscure cases, they are not, but they point the direction of investigation If we have a single characteristic symptom, one that we have called basic, then of course our diagnosis is complete and the treatment definite. 2d. By differential diagnosis, we undertake to determine the location and character of disease by an analysis of the symptoms. Seeing which of them are common to all of the supposed affections-which are undeniably special to a certain part or function-until we have found one or more that locate the disease and determine its character. 3d. By exclusion, we give the entire body an examination, determining the functions that are rightly performed, exclud- ing these, until finally we have localized the lesion and have determined its character. There is hardly a disease so obscure but that it may be ac- curately determined in this way, if proper care is used. Ne- cessarily we must know our Anatomy and Physiology, and the modern teachings of pathologists, then with caution and a right use of reason, we can hardly fail. Now if we have determined such obscure disease, and we have had no experienoe and can find no treatment in our books, how shall we proceed? Very certainly as follows: A drug is a remedy because it influences the part or func- tion diseased. It is an indirect remedy when its influence is dependent upon the disturbance of some other part or func- tion; it is a direct remedy, when its influence is directly upon the part. Now we have determined the functions that are changed, and the part affected, we think of those remedies which are known to exert a more or less direct influence on the particu- lar part or function; knowing the character of their action, and the want of the diseased body, we adapt the one to the 310 SPECIFIC MEDICATION. other. If the case is one new to us, we may have to experi ment, but the line of experiment will be a rational one, and likely to lead to good results.-E. M. Journal, June, 1872. Epidemic or Endemic Constitution of Disease. You have no doubt observed, that the diseases of some seasons, no matter how diverse in special characteristics, would have something in common, which something would be especially manifest in the treatment; that in some seasons Quinine would cure every thing, in others the sedatives would cure every thing, in others a remarkable benefit from Podo- phyllin, so that when you had once determined a good treat ment, you would persist in it for all affections, with very little modification. And this brings prominently before us the fact, for fact it is, that there is an endemic or epidemic constitution of dis- ease, that should be well studied, and always regarded in treatment. Success or failure will very frequently depend upon this knowledge, and it is something that must be re- learned every year. It was a prominent doctrine of Rademacher and his follow- ers, and he had remedies for three such constitutions. These were Iron, Copper, and the Nitrate of Soda. There was some truth in this-how much I don't know, for I have not had the opportunity to experiment, and, indeed. have not had time to give his works the examination they should have, as I read German slowly, and they have never been translated. I believe, however, I have passed through one year, in which Iron was the remedy for almost every thing, and think probably some of our old practitioners may recollect it, if they by chance had used Iron. The season commenced in December with a large number of cases of erysipelas, for which Iron was a specific, and for some fourteen months I prescribed Iron daily for almost every thing, with the most flattering results. I have experimented with Copper and Ni- trate of Soda to but a limited extent. CONSTITUTION OF DISEASE. 311 Rademacher applied the principle to chronic disease. Grau- vogl says: “Our experience gained by this school is worthy of special consideration, that, in old chronic diseases, the previous epidemic constitution, always decides, first of all upon the present indication of a remedy; hence, in every case which comes up for treatment, the time of its first ap- pearance should be learned, as far as possible, for by this, frequently, if the then epidemic curative remedy is known, the primary seat and the primary kind of the diseased pro- cess are known also, and this very remedy will still effect a cure, if a cure is yet possible, or, if the disease is not already succeeded by another disease of the first affected organ or blood, or if disease of another organ has not ensued. But, even in this latter case, that knowledge gives the point of de- parture for the whole chronic affection' (6 'That is in gross what we see happen on a smaller scale, after strong or oft-repeated doses of long-acting remedies. First appear symptoms at the point of application, then of its reception in the blood; finally, the affections of the specifi- cally affected organs and systems in succession, and often at great intervals, as we have observed very distinctly with quicksilver, for instance. The only difference consists in this, that epidemic injurious influences, often after very many years, to the surprise of many, bring to view their continued operation as a token of the presence of their results under various forms of disease, while the continued operation of drugs is of proportionally shorter duration."-E. M. Journal, June, 1872. 312 SPECIFIC MEDICATION. CASES, Illustrating Specific Medication. The reader by this time will be impressed, that Specific Medication must be based upon specific diagnosis; that we prescribe medicines for pathological conditions, and not for names of disease; and that we will have success just in pro- portion as we learn the meaning of symptoms, and train our senses to close observation and an analysis of all the evi- dences of changes of function and structure. True, we have to closely and carefully study our Materia Medica, and learn the influence of drugs upon the human body; this is an essential element of specific medication. But however well the physician may know his Materia Medica, if he can not recognize the evidences of disease, and the rela- tion of remedies to definite conditions, he must fail in prac tice, or at least have only that success which comes from na ture's efforts to cure, or by hap-hazard or indirect medication. I confess it is not easy to learn this direct relation between disease and remedies. It is probably more difficult now than it will be years hence, when, having been more thoroughly studied, it will be presented in a clearer light. Still it is our duty to make the most of what we have, trusting to time and careful observation to make up our present deficiencies. I have thought that a report of cases illustrative of specific medication, would aid the reader, especially as they point out the symptoms or conditions of disease, that indicate special remedies. Many of these cases have been reported in the Eclectic Medical Journal, but I have given them the usual classification here. Intermittent Fever. We will take a series of cases illustrative of the treatment of intermittent fever. I confess, at the commencement, that I have not seen one case where others have seen fifty or one INTERMITTENT FEVER. 313 hundred, but I am very sure I have seen them with different eyes. It has been my fortune, however, to have seen, in the way of consultation, a large number of intractable cases, and one learns more from these than from the ordinary run of simple ones. I may say, at the commencement, that while I value Qui- nine as a specific against the malarial poison (whatever it is) I do not regard it singly as a specific for the disease, or its common use as being good practice. I should prefer to dis- pense with it wholly in the treatment of periodic disease, than use it as badly as many do. It is passing strange that doctors having eyes and a mode- rate amount of brains behind them, should persistently use Quinine in the most varying and opposite states of disease— in cases which have not a single thing in common but peri- odicity, and persist in its use when failure follows failure, and the only result of its administration is quinism-far worse than the original disease. When a case of ague presents itself, we ask ourselves the question, is it simple, or is there functional or structural dis- ease? If simple, the intermission is a state of perfect health, less a certain debility. If complicated, we wish to determine the exact condition of disease. If simple, we give Quinine at once; if complicated, we remove all functional and struc- tural disease by appropriate remedies, and then, wheu simple, we give quinine if it is necessary. A large number of cases will not require it. I administer Quinine differently from most physicians. The patient being properly prepared for its action, has a single dose of sufficient quantity to break the ague (grs. x. to grs xv.), three hours before the expected chill. This is best taken dissolved in a small quantity of water by the aid of sulphuric acid. This may be called the big-dose plan. I have treated a few cases with a single dose of one-eighth of a grain, given at that period of the day when the patient is most himself—usually if the period of intermission is divided into three parts, the end of the first period will be the best time 27 314 SPECIFIC MEDICATION. I will be glad if some of our readers, who have an abundance of cases, would try the small dose. CASE I.—Intermittent Fever-Inflammatory.—F., æt. 41, a strong, robust man, has had ague for five months, contracted in the Wabash Valley. Has had it broken with Quinine, on an average, every two weeks. Has had a Thomsonian course of medicine, been freely purged with Podophyllin, and his liver tapped with Calomel and Blue Pill. His chill lasts from thirty minutes to two hours, and the fever severe, for six to ten hours, during which he suffers intensely. Is now quo- tidian. Examination during the intermission shows: a dry, harsh skin; a contracted tongue, with slight white coat down its centre, edges reddened; some headache and backache at times, face flushed and eyes are bright and somewhat intole- rant to a bright light; bowels constipated, (the patient claims they would never move without physic); urine diminished in quantity one-fourth, not changed in color. The pulse is 80, full and bounding. Temperature 100° scant. Prescribed-R Tinct. Veratrum, gtts. xxx.; Tinct. Gelse- minum, 3j.; Water, 3iv.; a teaspoonful every hour until the pulse loses its full and bounding character, and the skin softens, then every three hours. Chlorform, gtts. xv. at the commencement of next chill. Acetate of Potash commenced on the third day, 3ij. daily. Hot foot-bath for thirty minutes every night on going to bed. The chill and fever became lighter each succeeding day, and did not recur after the fifth day. If I had not been em- ploying the remedies to determine their full influence in curing an ague, I should have given Quinia, grs. x. the third day, which, I have no doubt, would have broken the chill at once. The cure was a permanent one. CASE II.-F., æt. 27, a brother of Case I. contracted the disease at the same time and place, and has pretty much the same experience, though Quinine has held the disease in check INTERMITTENT FEVER. 315 for longer periods. He is a spare man, and in appearance quite different from his brother, but the chill and fever are quite as severe. Ague is now tertian. Examination during the intermission shows: a dry, harsh skin; pulse 86, small and hard; temperature 991; urine scanty and high-colored (coloring matter biliverdin); tongue contracted and reddened; bowels regular. Can not now take the smallest dose of Quinine without unpleasant head symptoms, and an increased severity in the fever. Prescribed-B Tinct. Aconite, gtts. xx.; Tinct. Asclepias, 3j.; Water, 3iv. A teaspoonful every hour during the fever, every two hours in the intermission. Quinine inunction twice daily of: B Quinia Sul., 3ij.; Lard, 3ij.; Oil of Anise, 3ss. M. Had two recurrences of ague after the treatment was commenced, but made an excellent recovery. CASE III.-R., family of three, father, mother and child of three years. Had ague last year, and were cured with Qui- nine. (But like many cures with this drug, they were not entirely well.) Ague commenced this year in May, and for three months they have had it continuously. No means em- ployed had done any good, except to break it on the father for one week. It is of the tertian type, but fortunately the sick day of one is the well day of the other. The sick day is a sick day in fact, as they keep the bed the whole day. The father presents himself at the office on his well day. Examination shows-skin pallid and relaxed; pulse soft, open and easily compressed; temperature 99°; bowels tumid, ir- regular; hands and feet cold; eyes dull, pupils dilated; wants to sleep; tongue full, broad, with coating somewhat resem- bling that after eating milk. The others are represented as having the same symptoms. Prescribed-R Tinct. Aconite, gtts. xv.; Tinct. Belladonna, gits. xx.; Water, Ziv.; a teaspoonful every two hours. Child one-fourth the quantity. Also Sulphite of Soda, grø. xx. three times a day. 816 SPECIFIC MEDICATION. Father reported in ten days that neither he nor the child had had a paroxysm of ague since, (the child did not take the Sulphite.) The mother had but two chills, but though better the disease was not arrested. Gave a single dose of Quinine, grs. x.; chills stopped, and thus far have not recurred. The entire family seems to be radically cured. CASE IV.-W., Superintendent of Adams Express in the West, travels extensively in Southern Indiana, Illinois and Missouri; very strong and rugged, never had ague until August, 1870. Returned from Vincennes feeling very much depressed, had a slight chill, pain in head and back, intense. muscular pain in right side extending from shoulder to foot. Eyesight impaired, and partial paralysis followed the subsi- dence of the pain; ague quotidian. These were the symp- toms at each recurrence of the chills. I saw him soon after the second chill. The fever was very slight-notwithstanding the gravity of the other symptoms. Prescribed-B Tinct. Aconite, gtts. x.; Tinct. Macrotys, gtts xxx.; a teaspoonful every hour. The pain was speedily relieved by the prescription, and he slept well. Gave the suc- ceeding forenoon, fifteen grains of Quinine in two doses. It had no more effect on the ague than so much water, but pro- duced unpleasant head symptoms and deafness, which were persistent. Concluded to let Quinine alone, gave the first pre- scription only. There was a steady amendment, and the fourth day gave a single dose of Quinine, grs. x., and the dis- ease was at an end for the time. Small doses of Quinine were taken as a prophylactic in his next trip. Though the chills were stopped, the deafness continued, as did the slight paralysis. In September he had a recurrence of the disease in the same form. Concluded I would not use Quinine at all. Gave the Aconite and Macrotys the first day; then in addition-R Tinct. Nux Vomica, gtts. xx.; Water, Ziv.; a teaspoonful every two hours (the remedies being al- ternated.) He had no recurrence of chill after the third day, and recovered his usual health rapidly. Has been in a mala- INTERMITTENT FEVER. 817 rial region this year-used no prophylactic - and has felt nothing of it. The Nux Vomica was used in this case as a cerebro-spinal stimulant. CASE V.-Recent Ague.-S. has had quotidian ague one week; been purged freely; and has had as much Quinine daily as his head would bear; feels badly, is discouraged, and concludes he will change doctors. Characteristic symptoms-a broad, pallid tongue, coated with a white, pasty fur; breath fetid. Prescribed-B Sulphite of Soda, grs. xx. every three hours. Had no more chills, and made a quick and permanent re- covery. This is a typical case, and some physicians have found all the cases of a season to take this character. Thus we had 127 cases reported by one physician in 1868, cured with Sul- phite of Soda alone; Quinine failed almost uniformly. Instead of depending wholly upon Sulphite of Soda, how- ever, I would advise its use until this peculiar condition was rectified, and then give Quinine. Common Salt has been successfully employed in the same class of cases in doses of grs. xx. every three hours during the intermission. A large number of cases, by different prac- titioners, were reported in one of our Southern exchanges, some twenty years ago. CASE VI.- Ague with Subsequent Typhoid Symptoms.— Some fourteen years since I had to treat a very stubborn ague originating in the Little Miami bottoms. The cases would not yield to ordinary treatment; and in some, typhoid symp- toms gradually developed, and patients died of what was at first an ordinary ague. My first treatment was a complete failure, and it was only after I had seen a prescription of our old Quaker physician, Dr. William Judkins, that I had any success. had any success. It was very simple. Quinine, gr. j. every two hours during the intermis 818 SPECIFIC MEDICATION. sion, with the free use of water acidulated with Nitro-Muri. atic Acid. The treatment was a complete success. Characteristic symptoms-deep redness of mucous tissues, and dark coatings upon tongue; and to-day, with the same symptoms, I should use the same treatment. CASE VII-Ague with Partial Congestion.-F. has had ague for six weeks; has been twice broken with Quinine. Now Quinine has no influence, only to produce cerebral symptoms and increase the severity of the disease. Has been thoroughly purged with Podophyllin-worse. Has had two emetics-worse. Ague tertian. His skin is sallow; yellowish discoloration about the mouth; complains of dull pain in right side under false ribs extending to shoulder; and occasional umbilical pains; en- largement of spleen, bowels irregular, stools clay colored; has frequent attacks of nausea; urine highly colored with bile; pulse in intermission 90, temperature 100°; has little appetite, and is very much debilitated. Prescribed-R Tinct. Nux Vomica, gtts. x.; Water, 3iv.; a teaspoonful every hour. The disease gives way slowly— patient had two chills after the medicine was commenced. The remedy was continued without change for two weeks, and the cure was permanent. CASE VIII.—Ague with Impaired Innervation. — B. has had tertian ague for two weeks. There is nothing remarkable about the case, except the loss of energy and desire to do anything, and the fact that ordinary means do not reach it Pulse soft and open, 70 per minute; temperature 99°; skin relaxed and moist; tongue broad and sodden; bowels irregu- lar, stools semi-fluid with scybala; urine in large quantity, colorless. Prescribed-R Strychnia, grs. 1-30th, every four hours dur- ing the intermission. Had no recurrence of chill, and made a good recovery. I may say in this connection that the treatment of ague INTERMITTENT FEVER. 819 with Strychnine is sometimes remarkably successful, and is again a complete failure. I think I have pointed out the Strychnine case, so that any of our readers may know it—but I would be very glad to have it confirmed by other observers Dr. Shultz, of Logansport, employs Strychnine, quite fre- quently, by hypodermic injection, and expresses himself pleased with its action. CASE IX. Ague with Gastric Atony and Secretion of Mucus.-Some thirteen years since I had to treat a number of cases of ague in river men. They had contracted the dis- ease on the Lower Mississippi, Yazoo and Red River, and it was remarkably stubborn, some cases being continued from June to Mid-Winter, with temporary arrests from Quinine. Three-fourths of them presented the following symptoms- tongue broad, heavily coated at base in the morning, bad taste in the mouth, weight and fullness in epigastrium, fetid breath, and unpleasant eructation after eating I treated every case with thorough emesis, (Compound Powder of Lobelia), repeated in some cases, and the use of a solution of Acetate of Potash, 3iij. in twenty-four hours. No Quinine was used. The treatment was a decided success, but I obtained a reputation for giving nasty medicine that I never will get rid of. A few days since I met one of the pa- tients, and he had to report how Dr. Scudder turned him in- side out—but, says he, “I have been in the South every Sum- mer since, and I have not had a shake." Is this Specific Medicine too? Yea, verily, and very good practice it will be found in just such stubborn cases. CASE X.-Ague with Intestinal Torpor.-I will not give a case, for any one of my readers can put his finger on one or more. Recollect that constipation is not the symptom; on the contrary the bowels will frequently move every day, yet the patient says the unpleasant feelings are never removed by it. Characteristic symptoms-tongue full and coated from base to tip with a yellowish, pasty fur; bowels tumid. 320 SPECIFIC MEDICATION. Prescribe-Podophyllin thoroughly triturated, adding a small portion of Capsicum or Ginger, to free purgation. To be followed by Quinine when the system is in proper condi- tion. CASE XI.-Ague treated with Arsenic.-The first year of my practice I was poor, and found it difficult to make both ends meet. Late in the Fall I was applied to by a Southerner, who told me he had had ague for over a year; he had tried everything, and could get no relief. Could I help him? He had taken Quinine, Fowler's Solution, Salicine, and indeed all the common drugs. I answered, yes, I'll cure you, (though I wasn't half as confident as I seemed). Prescribed-Filled an ounce bottle one-fourth full of Homœopathic pellets, and dropped on them Fowler's Solution, gtts. v. Ordered ten of these every four hours. Only one chill afterwards, and made an excellent recovery. The gentleman came to my office in about ten days, and after telling me that he thought he was well, and was going home, said, "Now, Doctor, I wont ask you what your bill is. There is $50 for the bottle of little pills, and you have my thanks in addition." That was the best money I ever made, for it enabled me to live until sufficient practice came. ! In 1864 I had to treat three students who, coming from Missouri and Illinois, brought ague with them. During October and the first two weeks of November, they kept the disease partly in check by the use of Quinine and Podophyllin pills. But finally these failed, and the disease commenced to present typhoid symptoms, one of them being confined to his bed. The symptoms were peculiar. There was no seeming loss of flesh, but the tissues seemed sodden, and expressionless. The tongue and other mucous tissues were tumid and bluish ; a brownish fur gathered on the tongue, and sordes about the teeth; the bowels were loose, stools papescent; the chills not very severe, but the fever intense; pulse in intermissions, soft and fluent, during fever small and thready. INTERMITTENT FEVER. 321 They were very bad cases, one was in a dangerous condition. They had taken the usual remedies, Quinine in full doses, as well as Strychnine; what should I give them? I decided at once to try the little pills. In a week the sickest one was at lectures. Prof. Jones was told, and he was asked, What the little pills were made of?" Of course he couldn't tell, and the very thought of little pills was an offence in his nostrils, and his remarks about "Dr. Scudder and his little jokers" were a standing subject for fun for many sessions. Will the "little jokers" cure all cases of ague? Indeed they will not. I wish they would, for they are far pleasanter than Quinine. But they will cure some cases, and those are usually inveterate ones that Quinine won't reach. But!" and I imagine some one holds up his hands in holy horror," that's giving Arsenic." That's a fact, so it is. I had forgotten that "ratsbane "was in the list of tabooed medicine. Got it mixed up with "hensbane" somehow. Very sorry, but these are facts, and we have need to know them. CASE XII.-Ague treated with Quinine Inunction.—I re- ported my first case of ague cured by Quinine inunction some twelve years ago—and as it was a typical case, I may as well give it here. A Mrs. Clark had suffered with ague for some five years— broken at times-but never free from its effects. It is now September, and she has had it since May with but one respite. Is very feeble, very sensitive, very nervous, and suffers severely. Can not take a grain of Quinine without cerebral symptoms; can not take the ordinary medicines in use, because they nauseate and are rejected by the stomach. Evidently a very bad case, and the young Doctor is at his wits' end to know what to do. Had just been studying the action of remedies, and was at that time especially interested in cutaneous absorption, and concluded I would ask the skin to do the work of the stomach. 322 SPECIFIC MEDICATION. 射 ​Ordered-B Quinia. Sul., 3ij.; Lard, 3ij.; to be thoroughly rubbed into the axillæ, and the anterior surface of abdomen. No more chills; made a slow, but excellent recovery. I have used Quinine inunction in scores of cases since—not always with such positive results, but nearly always with Denefit. In children it is a favorite remedy, especially in cases of slow infantile remittent. A physician of our school in Dayton, Dr. Kemp, tells me he has employed it in a large aumber of cases this year and last, and with the most flatter- ing results. CASE XIII-Ague cured by Cutaneous Absorption.-John J. contracted ague during a visit West, Has been treated some weeks without benefit; has a horror of Quinine. Used Ether Spray to chill a surface three inches in diame- ter over the epigastrium, and applied a Solution of Quinine An application daily for a week, and the disease was perma nently cured. I have used Quinine in this way in a few cases, and in part of them with excellent results. Ether applied with a sponge, and evaporated by fanning, answers quite the same purpose as the spray apparatus. The Quinine is absorbed when reaction occurs, and it makes little difference to what part of the body it is applied, so the skin is thin. CASE XIV.-Ague cured with Boletus.-M. has had ague off and on for two years. Quinine breaks the chill, but it returns within a week-and then for a time the drug has no influence. There is no special indication for any remedy. Prescribed-B Tincture Boletus, 3j.; Water, 3iv.; a tea- spoonful four times a day. Had no more chills, and the cure was radical. I would be glad to have reports from physicians using Boletus, to show the special condition. if any, in which it is curative. For whilst curative in some, in others it exerts no more influence than water. CASE XV.-Chronic Ague.-M., æt. 38, a river man, has been in the South-West for some six years, has had ague for INTERMITTENT FEVER. 328 the last three. Quinine will break it for a few days, but makes him feel so badly, that he dislikes to take it. His skin is sallow, looks full and waxy, and has lost its natural elasticity; extremities are cold most of the time; urine in usual quantity, but of light specific gravity, 110 to 116; pulse is full, but shows want of power; bowels torpid; spleen much enlarged and tender; slight cough; tongue broad and furred white; appetite poor. Prescribed-B Tinct. Veratrum, gtts. xx.; Water, 3iv,; a teaspoonful every two hours. R Acetate of Potash, 3ij. every twenty-four hours, in a considerable quantity of water. R Tincture of Nux Voinica, gtts. ij. every morning in a glass of water. Recovery was slow, but at the end of the month every vestige of ague had disappeared, and the patient was gaining flesh rapidly. The cure was permanent-has had no symptom of ague since, now three years. The treatment of ague with Acetate of Potash was strongly recommended by Golding Bird in his work on Urinary De- posits, and will be found an excellent plan in some cases. CASE XVI.-Chronic Ague.-C., æt. 26, has been a steam- boatman on the Lower Mississippi for three years. Had ague the first year which was cured with Quinine. Ague the sec- ond year was treated for some time without success, and was finally broken with Fowler's Solution in large doses-leaving him with the peculiar puffy condition of face and oedema of lower extremities, that so frequently follows this use of Arsenic. The third year the ague came on, and nothing would reach it, and he came here in September. Skin is sallow, but looks like parchment and is tightly. drawn to the tissues; pulse is small and frequent; urine is scant and high colored; bowels irregular, with occasional mucous diarrhea; tongue looks lifeless, and is covered with a milky looking coat; appetite is poor; greasy eructations, and occasional vomiting of mucoid matter. Prescribed-B Triturated Podophyllin, 1-100, grs. v.; Hy. 824 SPECIFIC MEDICATION. drastin, gr. ss. for a dose, three times a day. Quinia inunc- tions morning and night thoroughly. Every third day a thorough washing with soap and water. Gained from the first day, and ceased taking medicine before the end of the third week. No recurrence of the disease. The reader is ready to ask by this time, "Dr. Scudder, did you ever have any unsuccessful cases? Do you want us to believe that your medicine always works like a charm?" I answer, I have cases all the time in which my diagnosis is at fault-sometimes from carelessness, sometimes because I don't know. I would report these cases as well if I could see how a report of my want of care or want of skill could benefit the reader. I doubt not every one of my readers has a sufficient amount of that experience in his own practice, and need not go abroad for it. What we want to know here, as in every other disease is- the exact condition of disease, and when we know this we can prescribe with certainty. Very certainly it requires some- thing more than to say-" this is ague and I'll give Quinine;" that is further than I can go in Specific Medication. CASE XVII-Chronic Ague cured with Iron.-S., æt. 31, has suffered with ague for the past three years. It has been treated with Quinine, and he is now suffering from quinism, and at times the nervous symptoms are almost unbearable. The special symptoms are—a full blue tongue, and a cutaneous trouble showing the peculiar red glistening surface we see in some cases of erysipelas. Prescribed-R Tinct. Muriate of Iron, 3ss; Simple Syrup and Glycerine, aa. Živ; a teaspoonful four times a day. As a bath a weak solution of Sulphate of Tron. To wear red flannel. Made a good recovery, improving from the first, and has had nothing like ague for the six months past. CASE XVIII.-Chronic Ague cured with Nitric Acid.- Dr. H., has suffered with ague for the past three years, which he has treated with Quinine-which will break the chills, but REMITTENT FEVER. 325 will not keep them off. Now Quinine irritates the nervous system, and the remedy is worse than the disease. Its mani- festation now is in the form of periodic cephalalgia. Special Symptoms: A peculiar violet color upon a tongue moderately red. The lips and finger nails show the same violet haze Prescribed--R Nitric Acid, gtts. xx; Water, Simple Syrup, aa. Zij; a teaspoonful every three hours. The head- aches recurred for three days, decreasing in severity, and there was complete and permanent recovery. I have prescribed Nitric Acid in various forms of Chronic disease, when this peculiar symptom presented, with most satisfactory results, and would advise its trial. Remittent Fever. What we want to learn in regard to this disease might be divided into three parts. That, though the disease is called bilious fever, the liver has nothing to do with it. That, though classified as arising from vegetable malaria, for which Quinine is the specific, it is always best to treat the disease as if it were not so, until the fever, commencing to pass away, leaves the system in good condition for the kindly action of Quinine. And, lastly, there are cases, and seasons, where Quinine must be avoided, if we wish to have success, and not injure our patients. These points are pretty clearly set forth in the "revised edition" of my practice, to which the reader is referred. CASE XIX.-Simple Remittent Fever.-There are locali- ties in which the disease for several seasons will present a large number of simple cases. The patient has a well marked chill, followed by febrile action, and then a very decided remission, together occupying a period of twenty-four hours, and repeating the febrile exacerbation and remission in the same way, each succeeding day. You examine the patient carefully, and you find nothing but fever-no particular lesion of one part or function, more than another. 326 SPECIFIC MEDICATION. In these cases it is pretty safe to follow the rule of Prof. I. G. Jones-Give a sufficient amount of Quinine during the decline of the exacerbation and remission to stop the disease. It will require from ten to fifteen grains. But if it fails the first time, it is safer to prepare the system for its kindly action. CASE XX.-Simple Remittent Fever-killed by the Doctor. -James G., æt. 27, a strong, robust man, was attacked on a Tuesday with a chill followed by high fever; the next morn- ing a decided remission, lasting an hour, then febrile action; no symptoms indicating complication, or danger. An Eclectic was called, and commenced the treatment by the administra- tion of Podophyliin pills to violent catharsis; then Quinine in divided doses; then Podophyllin in alterative (?) doses (to tap the liver); then more Quinine, alternated with Podophyllin. Remainder of treatment a nauseous diaphoretic stew, and sweet Spirits of Nitre. Saw the patient in consultation the next Tuesday morning. Had furious delirium, requiring to be held on the bed; skin dry and harsh, pungent heat; mouth and tongue dry, tongue furred, bleeding, almost black sordes upon teeth; pulse 140, small and hard; eyes injected, pupils contracted, had not slept for three days. Prognosis-death; verdict-d-n the. doctor. Did I ever do this thing? Probably not so grossly, though it was rather from skepticism than good teaching that I escaped. If I had followed instructions closely, I should probably have ended some of my patients in the same way. CASE XXI. Simple Remittent Fever Badly Treated.-S., æt. 24, a robust, healthy woman, was attacked with remittent fever, (Dr. called it bilious,) August 2d, From the history of the case it was the simple form of the disease without complica- tion. An active cathartic was prescribed, followed by altera- tive doses of a mercurial. Quinine was given in broken doses, alternated with Dover's Powder, Spiritus Mindereri, and Veratrum. The patient continued to get worse day by day, REMITTENT FETER. 327 and when I was called on the ninth day, was in the following condition : Tongue elongated and pointed, very dry, mucous tissues dusky red, brown fur on center of tongue, and sordes on teeth; pulse 130, small and sharp, temperature 106° in the evening, 1034° in the morning; delirium-a low muttering; skin harsh and dry; urine scant and very red, bowels continuously loose from the action of medicine, from the first. Prescribed-B Dilute Muriatic Acid, 3ss.; Simple Syrup, 3jss.; a teaspoonful in water, every three hours. B Tinct. Aconite, gtts. x.; Tinct. Gelseminum, 3ss.; Water, 3iv.; a teaspoonful every hour. A general sponge bath with soap and water. After the second day Quinine inunction. A milk diet. No change was made in this treatment, and the patient was convalescent in eight days after I took charge of her, making seventeen days from the chill. CASE XXII.-Remittent Fever.-O. B., æt. 17; was called Aug 20th to take charge of the case, then in the fifteenth day, the physician in attendance saying that the case must prove fatal. Had the following history from parents and physician : Case not very severe at first; after sharp catharsis Quinine was freely administered-patient much worse. More physic and more Quinine, aided by Veratrum and Spiritus Mindereri— still worse, Passing into the second week a diarrhoea became a marked feature, for which was prescribed the usual astrin- gents and Bismuth, but without any effect. Quinine still pushed. Condition on fifteenth day: Patient very feeble, lies on his back, has cough and difficult respiration, has eaten nothing for three days, nor slept. De- lirium constant, eyes bright and wild. Skin harsh and dry. urine scanty. Diarrhoea a marked feature, actions passed in bed whenever he coughs. Pulse 124, full but oppressed. Temperature 103° morning, 106 evening. The tongue is not much furred and is moist, but a dusky red. The patient is 328 SPECIFIC MEDICATION. very deaf, and has been so since the first week. Physical ex- amination of the chest gives dullness on percussion over the lower lobe of both lungs, and moist blowing sounds over the entire chest. Prescribed, for the diarrhoea-R Tinct. Aconite, gtts. X.; Tinct. Ipecac, gtts. xx.; Water, 3iv.; a teaspoonful every hour. It did its work well, and we had no more trouble with diarrhoea after the fourth day, except for a brief period in the fourth week. The deep coloration of mucous membranes in- dicated an acid, and dilute Muriatic Acid was given in the usual way. Milk diet-the milk given hot four times a day, sometimes oftener. For the delirium, I employed Prof. Howe's method-B Tinct. Aconite, 3j.; Chloroform, 3iij. M. To be applied freely to the nape of the neck, to control the cerebral disturb- ance and give sleep. To aid this, Gelseminum was given with the Aconite when there was no further need of the Ipecac; but this was only an aid, and we depended principally upon the local use of Aconite and Chloroform. The disturbed condition of the brain was the result of Quinine, and it was the severest and the most persistent I ever saw. Though the patient was in good condition, and should have convalesced rapidly after the fourth week, we were obliged to use the local application of Aconite, for five weeks, making seven from the commencement, in order that he might sleep. Even now, thirteen weeks from first attack, his mind is not steady and he has the unpleasant roaring in his ears and deafness. CASE XXIII.-Simple Remittent Fever Badly Treated.- O., a married woman, æt. 36, has been in feeble health for some years, though stout in body; was attacked with simple remittent fever, thought it was but a cold, and took on two succcessive days a patent pill to free purgation. Growing worse, a neighbor who dabbled in botanic medicine, proposed to give her a big sweat. This was effectually done, with a vapor bath, and an infusion of "boneset," and continued for REMITTENT FETER. 329 a day and night. Patient so much worse, that the writer was sent for on the fifth day. Condition:- Skin relaxed and bathed in perspiration, extremities cold, trunk hot. Pulse 120°. Tongue moist, and covered with a dirty fur, mucous membranes blueish. Bowels acted twice during the day, stools large, papescent and light colored. Urine moderately free. No appetite. Complained of sense of fullness and also pain in the hypochondria and epigastrium. Prescribed-R Tinct. Aconite, gtts. x.; Tinct. Belladonna, gtts. xv,; Water, 3iv.; a teaspoonful every two hours. B Tinct. Nux Vomica, gtts x.; Water, 3iv.; a teaspoonful every two hours. Quinine inunction. Milk diet. R Sulphurous Acid, 3ss.; Simple Syrup, 3jss.; a teaspoon- ful every three hours until the tongue cleaned. The patient progressed favorably from the first, but it was two weeks before fully convalescent. CASE XXIV.-Remittent Fever presenting Typhoid Symp- oms. Mrs. S., æt. 56. Has suffered for four months with the unpleasant ague of this year, for which she has taken different remedies, and prescriptions from two schools of med- icine, but without benefit. Finally, on a visit to her son, the fever assumed a remittent form, and she was confined to her bed. Symptoms-a marked chill with great prostration has been occurring every day, for three days; before the ague was quo- tidian. Now her pulse is frequent, small, and oppressed, skin dry and harsh, temperature 104° in afternoon, 102° in morning, bowels loose, tongue moist and coated with a very dirty brownish coat down the centre, sleeps but little, is very feeble and depressed in spirits. There is a tendency to cold- ness of the extremities-the feet will get cold if there is not a hot iron in bed, and the hands get cold when laid upon top of the cover. Prescribed-B Tinct. Aconite, gtts. x.; Tinct Belladonna, gtts. x.; Water, 3iv.; a teaspoonful every hour. On the second day, in addition, R Sulphurous Acid, 3ss.; Simple 28 330 SPECIFIC MEDICATION. Sirup, 3jss. M. S. A teaspoonful every three hours. On the fourth day, there was noticed a peculiar yellowness around the mouth, and the patient complained of umbilical pains, for which I gave: R Tinct. Nux Vomica, gtts. x ; Water, 3iv. ; a teaspoonful every two hours alternated with the sedative. The patient was free from fever by the seventh day, and made a sound and permanent recovery. Though two months have elapsed there has been no recurrence of the chills. The need of Antiseptics in Typhoid Remittent (Typho-Mala- rial) Fever-The cases of this year, 1871, have shown the marked importance of Antiseptics in these diseases. Not a single case of the seventeen that I treated, but was benefited by their use, and in some the need of the antiseptic was s0 marked that it alone would have given marked success. We may study here seperately from the report of cases, four of the most important of these remedies-Sulphite of Soda Muriatic Acid, Sulphurous Acid, and Baptisia Tinctoria-the four fulfilling all the indications for an antiseptic treatment in all forms of disease. In the old routine of practice no one would have attempted to point out special indications for the use of either, but the writer would have said-here are four remedies that are likely to do good, try them in the order named until you find one to suit. I prefer, however, to select the remedy by certain specific symptoms, and not at random. Sulphite of Soda -The indications for this antiseptic salt are pallor of mucous membranes, usually fullness of tongue, and a pasty-white, or yellowish-white fur. We give it in doses of from five to twenty grains repeated every three hours. Muriatic Acid.-We prescribe the acid where there is deep coloration of mucous tissues (not bright red), tongue con- tracted, coatings and sordes becoming brown as the disease aavances. The usual prescription is: R Dilute Muriatic Acid, 3ss.; Simple Syrup, 3jss. M. A teaspoonful every three hours, largely diluted with water. Sulphurous Acid.-This is one of the feeblest of acids, and one of the most powerful of antiseptics. The indications for 1 REMITTENT FEVER. 881 its use are—a moist tongue, neither pale nor deep-red, but showing a very unpleasant dirty clay-colored coat in the centre. The patient complains of fullness and weight in the epigas- trium, an unpleasant taste in the mouth, and frequently has a disgust for food or drink. We prescribe it as follows: R Sulphurous Acid, 3ss. ; Simple Syrup, 3jss. M. A teaspoon- ful every three hours. Baptisia Tinctoria.-There are none of our antiseptics that I value higher than this, and there is none which will give speedier relief if carefully prescribed. The indications for its use are clear (some of our readers may pronounce that queer)—fullness of mucous tissues, especially of throat, with bluish discoloration. Sometimes it is a bluish pallor, but more frequently it is deep bluish-red coloration In the ma- jority of cases, the breath will be fetid, fullness of epigastrium, tumid bowels, slimy offensive feces, and unpleasant odor both of urine and cutaneous excretion. I prefer to give it in infu- sion, 3ss. to boiling water, 3iv.; a teaspoonful every two or three hours. The Use of Belladonna.—In the treatment of the fevers this year, we have found that Belladonna was a very important remedy. Associated with Aconite, it would cure ague, when Quinine had failed, and in many cases of this typho-malarial fever, its beneficial influence was marked, both upon the nervous system and upon the circulation. Now what is the specific indication for Belladonna? It is clearly this an enfeebled capillary circulation. If this lesion is principally of the brain, we have impaired innervation- dullness, somnolence, coma; if of the spinal cord-impaired respiration, urination, defecation, but more markedly a ten- dency to congestion of the thoracic and abdominal viscera. How do I know that Belladonna stimulates the capillary circulation? I knew it nearly or quite ten years ago through Brown-Sequard's eyes-he saw the dilated capillaries contract under the general influence of Belladonna in small doses, as plainly as I see my hand carrying the pen over this paper. And I have seen it ever since, in the subsidence of symptoms 332 SPECIFIC MEDICATION. caused by capillary congestion, where the remedy is properly administered. CASE XXV.-Remittent Fever.-J. H., æt. 28, has been feel- ing badly for the past ten days, and has been confined to the house for three days. Has had two chills, with constant fever since—but slight morning remission. Says he feels very sick, can not sleep, and complains of a sense of weight and oppres- sion in epigastrium, and indeed the entire abdomen. The pulse is 120, full but not hard, temperature 1041° even- ing, 102° morning, skin hot but not very dry, urine scanty and odor very unpleasant, bowels constipated. The mucous mem- branes of the mouth markedly pallid, tongue full and coated with a thick white fur. Prescribed--Add Bicarbonate of Soda to Water to make a pleasant drink, to be taken ad libitum. R Tinct. Aconite, Tinct. Belladonna, aa. gtts. x.; Water, 3iv.; a teaspoonful every hour. A soda bath once daily. Milk diet. Was mark- edly improved the first twelve hours, sleeping at night, and was convalescent the sixth day of treatment. In this case the indication for the use of the Salt of Soda was very marked, hence this became the principal element of a successful treatment; and though the case was a severe one it rapidly yielded to these simple means. CASE XXVI.—Remittent Fever.—Mrs. S., æt. 32, has been suffering with "bilious fever" for six days, and concludes to change physicians. Presents no very unfavorable symptoms, though the friends claim that all the medicine she has taken has made her worse. Symptoms-skin dry and harsh; evening temperature 106°; features sharpened, eyes bright and intolerant of light, is restless and uneasy, and does not sleep well; urine scanty and high colored; has been freely purged, but bowels still consti- pated; pulse hard, 120; mouth dry, tongue contracted and beginning to fissure, brownish sordes in fissures and forming on teeth; color of mucous membranes deep-red; can not take · REMITTENT FEVER. 833 food or medicine without unpleasant sensations in the stomach, and nausea. Prescribed-R Dilute Muriatic Acid, 3ss.; Simple Sirup, 3jss. M. A teaspoonful every three hours-added to water to form a pleasant acid drink. R Tincture Aconite, gtts. x.; Tincture Gelseminum, gtts. xx.; Water, 3iv.; a tea- spoonful every hour. An acid bath. Milk diet. Was con- valescent the fourteenth day of the disease, the eighth of this treatment. CASE XXVII.-Remittent Fever.-A., æt 36, a railroad laborer, has been employed in the Miami bottoms, and came home very sick—has been feeling badly for a week. Complains of severe pain in back and limbs, muscles stiff, feel as if bruised-has had it from the commencement, chill two days since, high fever following, with morning remissions. Pulse 110, full and hard; skin hot and dry, temperature 105° evening; tongue natural in size and color, dry, with a clear white coat; bowels constipated; urine scanty and high- colored. Prescribed-R Tinct. Veratrum, gtts. xx.; Tinct. Aconite, gtts. x.; Tinct. Macrotys, gtts. xxx.; Water, Živ.; a tea- spoonful every hour. Alkaline sponge bath Milk diet. Marked relief from pain in twelve hours, and the fever de- clining to the fourth morning of treatment, found the skin soft, pulse soft and full, tongue moist and cleaning-gave two doses of Quinine, grs. iv., at intervals of three hours, and the fever was arrested. CASE XXVIII.—Remittent Fever.-W. R. has been suffer- ing from fever for four days, medicating himself, aided by his family. Has taken at an emetic, has taken freely of Podo- phyllin pills, and on two successive days has had Quinine. Feels very badly, and is quite sick. Symptoms-pulse 110, small and oppressed; skin hot and dry; bowels loose from medicine; urine scanty but colored with bile; stomach irritable, with nausea; has an uneasy 334 SPECIFIC MEDICATION, sensation and fullness in hypochondria, with occasional um- bilical pain; cough beginning to develop itself unpleasantly; face is sallow, and yellowness is especially marked about the mouth. Prescribed-B Tinct. Aconite, Tinct. Ipecac, aa. gtts. x.; Water, 3iv.; a teaspoonful every two hours. & Tinct. Nux Vomica, gtts. x.; Water, 3iv.; a teaspoonful every two hours, alternate. A wet pack over epigastrium. Milk diet. Was free from fever the fourth day of treatment. CASE XXIX. Remittent Fever, with Suppression of the Menses. Mrs. J. has been feeling badly for ten days, has had the chills, but the last two days the fever is constant. It is now time for the menstrual period. Commenced treatment with the use of Veratrum and Aconite, the bath, hot foot-bath, a saline purgative, after- wards a saline diuretic, and continued in this way for five days, patient getting worse. Gave the sedative more freely, and in morning remission used the hot foot-bath and Ascle- pias, and followed with Quinine. Patient grew worse rapidly after the Quinine was given, being very restless, some delirium, and the stomach irritable. Treatment has now occupied seven days-without any benefit—and came to the conclusion that I had better study the case if my patient is to live. A few questions and a little thought point out the menstrual derangement as an important element of the disease. Pre- scribe-R Tinct. Pulsatilla, gtts. x.; Tinct. Macrotys, gtts. xx.; Water, 3iv.; a teaspoonful every two hours-alternated with: R Tinct. Aconite, gtts. x.; Water, 3iv.; a teaspoonful every two hours. A warm pack to lower abdomen. Patient was decidedly better in twelve hours, and the fever declined rapidly, though the menstrual discharge did not commence until the third day after this change of treatment, and when patient was nearly freed from fever. } INFANTILE REMITTENT FEVER. 335 Infantile Remittent Fever. If there is any one thing more than another that I prize, it is the name of being a good doctor for children.” And if there is any one thing more than another that the Old-School practice deserves deepest damna.ion for, it is their miserable life-destroying practice in the diseases of childhood. I shud- der as I look back on my earlier experience in medicine and recall the many cases where i have seen the innocents tor- tured, as only doctors can torture, and I wonder that people can believe in special providences, when such things were permitted. Give the little sufferer from the many ills of childhood, good nursing, cleanliness, proper food and rest, and you will have a treatment that at least does not violate the seventh commandment. Supplement this with the mild but direct remedies of our practice, and you relieve disease of half its suffering, shorten its duration, and save life. CASE XXX. Typical Infantile Remittent.-Pulse 120; temperature 104° in exacerbation; skin dry; tongue slightly reddened and covered with a whitish fur; restless and un- easy during the exacerbations. Remissions in the fever vary in different cases, sometimes but one, at others three, four or more, in twenty-four hours. Nothing but fever. Prescribe-R Tinct. Aconite, gtts. v.; Water, Ziv.; a tea- spoonful every hour. Bath once or twice daily. No other medicine. CASE XXXI. — Infantile Remittent, with Irritation and Determination of Blood to the Brain. A., æt. twenty-one months, was attacked with simple fever, and the nearest phy- sician was called, prescribing the usual cathartic and Sweet Spirits Nitre. The second day the child was very restless, its face flushed, the stomach irritable, fever high, and in the afternoon had a convulsion. Having been the family physi 336 SPECIFIC MEDICATION. cian, was now sent for. Symptoms-face flushed, eyes bright, pupils contracted, skin hot and dry, pulse 146, small and sharp, unconscious, moving head from side to side, involuntary movements of hands and feet-bad case. Prescribed-B Tinct. Aconite, gtts. v.; Tinct. Gelseminum, gtts. xx.; Water, 3iv.; a teaspoonful every thirty minutes, intil the fever is reduced and head relieved. Towel wrung out of cold water over stomach and abdomen. Had relief and sleep by 4 o'clock next morning. Reduced the proportion of Gelseminum to gtts. x, continuing every hour, and the fever ceased the fifth day. CASE XXXII.—Infantile Remittent Fever, with Cerebral Congestion.-Annie L., æt. three years, was attacked with fever August 4th. The mother noticed that she was very dull, and slept with her eyes partly open. Had a Homœopa- thic case in the house, and gave her Aconite. The night passed, and the child was worse, and I was sent for, seeing her about noon. The symptoms now were very distinct—the child was sleeping with its eyes half open, its face expression- less, the eyes dull, pupils dilated; the skin was hot and dry. pulse 130, symptoms of convulsions. Prescribed-B Tinot. Aconite, gtts. v.; Tinct. Belladonna, gtts. x.; Water, 3iv.; a teaspoonful every hour. The coma gradually passed off, the fever was reduced, and the next morning the child was comparatively comfortable and was discharged on the 9th. CASE XXXIII.-Infantile Remittent Fever, with Intestinal Irritation.-W., æt. 28 months, was attacked with fever Sept. 20th. Called the next day, found febrile action high, stomach irritable, and some three or four greenish watery discharges from the bowels. Prescribed-B Tinct. Aconite, gtts. iij.; Tinct. Ipecac, gtts. x.; Water, half a teaspoonful every thirty minutes until the stomach is relieved, then a teaspoonful every hour. Conva- Jescent on the morning of the 24th. INFANTILE REMITTENT FEVER. 887 CASE XXXIV. - Infantile Remittent cured with Nux Vomica.-Pat R., æt. 5, has been sick for a week past. Has had the city physician, who gave Quinine, which stopped the fever, and the patient was discharged. Fever returned, with nausea and vomiting, and I was sent for. Symptoms - Pulse 120; skin sallow and dirty, yellowish around the mouth; complains of pain in the abdomen; tongue broad, moist, and coated with a dirty fur. Prescribed-B Tinct. Nux Vomica, gtts. iij.; Water, 3iv.; give half a teaspoonful every fifteen minutes until the vomit- ing ceases, then a teaspoonful every hour. Better the next morning, has not vomited since the evening before; pulse 90; tongue showing a tendency to clean; rested well the after part of the night. Improved steadily, and was convalescent on the sixth day, no other medicine being given. CASE XXXV.-Infantile Remittent-Malarial.-Jessie C., æt. 4 years, was attacked with remittent fever September 3d. Called to see her on the morning of the 4th, presented the usual febrile symptoms, with some irritation of the brain. Prescribed-B Tinct. Aconite, gtts. v.; Tinct. Gelsemi- num, gtts. xx.; Water, 3iv; a teaspoonful every hour; with the usual bathing and nursing. There was relief from the nervous irritation, and some mitigation of fever, but the dis- ease continued. Continued the same treatment to the 9th, when I concluded, as the child had been on a visit to a mala- rial region, to give Quinine, grs. iij. There was no more fever. CASE XXXVI. - Infantile Remittent - Malarial.-Byrd Scudder, æt. 3, a stout, active boy, was playing for hours on a yellow clay bank, one of the hottest days in June. The next day he had a chill, and following this a very high fever, with but slight remissions. Irritation of the nervous system, and strong symptoms of convulsions. One of the sickest children I ever saw. Prescribed - R Tinct. Aconite, gtts. v.; Tinct. Gelsemi- num, gtts. xx.; Water, 3ıv.; a teaspoonful every hour. The 29 888 SPECIFIC MEDICATION. fever was but little influenced by the medicine, though the nervous system was relieved, and continued for thirty-six hours. Now there was a complete intermission of eight hours, when it recommenced as severe as before, and con- tinued forty-eight hours, with a second intermission. As he had an utter disgust for nasty medicine (which, by the by, he inherited from his father) I withheld Quinine, and continued the febrifuge. The fever came up as before, and continued again for thirty-six hours, and again an intermission but not as complete. Was now ready to give Quinine, and adminis- tered three grains, and ordered it by inunction. No more fever. I might report a score of cases in which I have adminis- tered Quinine early, with the result of increasing the disease. In malarial districts it becomes a part of the treatment of every case; in some being specific to the disease without other treatment, but in the majority the system should be prepared for its use as heretofore named. In our city, mala- rial disease is the exception, and we don't use Quinine so fre- quently or so freely. Continued Fever. CASE XXXVII.-Continued Fever. Experiment with Qui- nine. Charles W., æt. 23, had a chill November 20, had been feeling badly for some two weeks. When called on the 24th found the usual symptoms of continued fever, with no special indication for treatment other than this. Prescribed-B Tinct. Veratrum, gtts. xx.; Tinct. Aconite, gtts. x.; Water, 3iv.; a teaspoonful every hour. Use the bath once daily. As is common with these remedies there was slight abatement of the fever from day to day, until on the 27th it seemed as if but little more would give convales- cence. The skin was soft, pulse soft and open, tongue moist, the condition for Quinine. Ordered three grains every two hours for four doses. The first influence seemed that desired- the pulse gained fullness and came down to 70, and the sur- CONTINUED FEVER. 339 face became moist, but following this there was slight chill, and the fever came up rapidly. The next day the patient was far worse than he had been, and required constant and care- ful attention up to the twenty-fourth of the disease. From this, and some other experience of a similar kind, I learned not to give Quinine in large doses in continued fever M CASE XXXVIII.—Continued Fever. — B―—, æt. 36, has been feeling badly for ten days. Yesterday had a slight chill in the morning, and again in the afternoon, fever at night, gradually increasing. Has the usual symptoms of common continued fever, which is now prevailing, but without any special indication for remedies, other than this. Pulse full and hard, 110; temperature on the third day 103° morning, 105° evening. Prescribed-R Tinet Veratrum, gtts. xxx.; Water, 3iv.; a teaspoonful every hour. The usual bathing and good nurs- ing. No influence upon the fever seemingly, until the morn- ing of the fifth day, though the patient was relieved of suf- fering. Now the fever seems inclined to yield, pulse 84 in the morning and open, temperature 101°; afternoon pulse 96, temperature 1024°. Prescribed-R Tinct. Veratrum, gtts. xx.; Tinct. Aconite, gtts. x.; Tinct. Asclepias, 3j.; Water, 3iv. 6th day. Morning, pulse 80, temperature a fraction less than 100°; evening, pulse 90, temperature, 102°. Added Solu- tion of Acetate of Potash. 7th day. Morning, pulse 80, tem- perature 100°; evening pulse 96, temperature 102°. Tongue is moist and shows a tendency to clean; skin is soft and occà- sionally moist. Contiuued in this way with but little change to the fourteenth day, when the fever ceased, and the patient convalesced rapidly. In some cases, presenting like symptoms, I have added small doses of Quinine to the treatment with the effect of ar resting the fever sooner. CASE XXXIX.-Continued Fever. Special Indications for Treatment. I will next present my own case, as reported February, 1865. Treatment by Prof. King: 340 SPECIFIC MEDICATION. "Fortunately for me the type of continued fever changed about the middle of December; whereas previously every case was attended by disease of Peyer's glands and diarrhoea, (typhoid), after this time it was common continued fever without the least tendency to enteric disease. The first con- clusion forced upon me was that a physician is incompetent to prescribe for himself; as the disease came upon me, and as- sumed its most severe form without my being aware of what was the matter. "It was attended for the first week with very severe pain in the back, limbs, joints, etc., so much so that I supposed at first it was rheumatic fever. The simple means employed at first-hot foot bath, spirit vapor-bath and diaphoretics-hav- ing failed, on the fourth day, I resolved to try the virtues of Quinine to stop the fever, and to relieve the pain, and accord- ingly took fourteen grains in six hours, and repeated it the succeeding day. It did seem to arrest all the febrile symp- toms, but it was followed by great prostration and exhaustion of the nervous system. Having had enough of my own treat- ment, Prof. King was called to prescribe, and it is the means he used that I wish to notice. “My condition may be briefly described as follows: Tongue broad, and thickly coated with a white fur, bowels consti- pated, a feeling of weight and dullness in the basilar and pos- terior portions of the head, pain in the lower part of the back, and wandering pain in the limbs. Sleeplessness and nervous excitement, pulse 130, soft, small and very feeble. "The doctor claimed that the white tongue indicated acid- ity, not only of the stomach, but an undue amount in the blood. To relieve this, he ordered Bicarbonate of Soda, a teaspoonful to a tumbler of water: a swallow to be taken every few minutes during the day. Its taste was very pleasant to me, and its influence agreeable, and though I had not the slightest feeling of acidity of the stomach, I am satisfied that it supplied a material that was deficient. " To assist in removing the nervous prostration, and to re lieve the pain, my back and limbs were to be rubbed morning CONTINUED FEVER. 841 and night with brandy, holding in solution five grains of Quinine to the ounce; one ounce to be used for a bath. Of all the remedies I ever employed none had so speedy and pleasant an effect as this, and I continue it at the present time. I consider it an item worth recollecting. Internally I was given a combination of half a grain of Quinine with four grains of diaphoretic powder, repeated every four hours. Under this treatment my pulse came down, I obtained refreshing sleep, and by the third day, secretion from the skin and kidneys was established. To move my bowels, I was ordered one grain of Leptandrin, triturated with white sugar, three times a day; the doctor claiming that as soon as the liver was stimulated to action my bowels would move. Having had no operation for four days, the first three powders moved the bowels kindly; the first instance in which I was ever satisfied that the remedy would prove cathartic. Altogether, the treatment was a success, and I am satis- fied that certain parts of it are well worthy of trial. Conva- lescence has been slow, and I am still very feeble, but gaining ground every day. I have proven on my own person what I had long been convinced of, that the use of tonics and stimu- lants, in a majority of cases of continued fever, does not facili- tate convalescence, but that in many cases their action is the reverse of that desired. CASE XL.—Continued Fever. Requires an Alkali.—Jas. L- was attacked Dec. 4th with chill, pain in head and back and general .malaise; had been feeling badly for some days. Next day was better, but in the evening had a second chill. Third day started to business, but felt so badly re- turned home by 10 o'clock, suffering from chills, and went to bed; fever came up in the afternoon, and he passed a restless night. Called on the morning of the 4th. Pu'se 110, small and hard, temperature 1031°. Tongue moist, broad, thick, pallid, and covered with a white pasty coat; breath has a peculiar sweet, mawkish odor. 342 SPECIFIC MEDICATION. Prescribed-Bicarbonate of Soda in water as a drink ad libitum. R Tinct. Aconite, gtts. x.; Water, 3iv.; a teaspoon- ful every hour. A Soda water bath. Amendment from the first, and was convalescent by the seventh day of treatment. The joke was, there was a Regular physician in the house— a relation, who claimed that there was no salvation for the patient except by the use of Calomel or Blue-pill; insisting that the peculiar appearance of the tongue was a strong indi- cation for mercurials. CASE XLI.-Continued Fever.-Requires an Acid.—John B———, æt. 41, has been sick for two weeks with the prevailing fever, under regular treatment. Friends conclude to change treatment, and the attending physician is discharged, and I am called. Condition-Has been delirious for the past four days, and sleeps but very little. The face is flushed and dusky, eyes in- jected. The skin is dry and harsh, the urine scanty, the bowels freely acted upon by physic, are now irritable, abdo- men tender. Pulse 130; temperature 107° in the evening. The tongue is dark red, contracted, and covered with a brownish fur, sordes on the teeth. Prescribed-B Dilute Muriatic Acid, 3ss.; Simple Syrup, 3jss.; add to water to make a pleasant drink, and give ad lib- itum. Use an acid bath twice daily. R Quinia Sul., 3ij.; Dilute Muriatic Acid, 3iv.; a tablespoonful to a pint of water, for a bath. Milk diet. No change was made in the treatment, the patient improv- ing steadily to convalescence on the twenty-third day from the commencement of disease. nothing but an acid was Though the indications I report a typical case, in which used—it might be called a test case. for acids are so pronounced that they form the basis of a good treatment, yet we employ various means in addition, as they may be indicated. It might be said that twenty-one days being the natural du- ration of such a fever, the acid was a mere placebo. But I CONTINUED FEVER. 843 answer, there was relief from the more urgent symptoms with- in forty-eight hours, and this alone was worth working for, without reference to the duration of the disease. CASE XLII. Continued Fever, with Disease of Peyer's Glands--Typhoid Fever.-R, æt. 29, now in the second week of a typhoid fever, has a sudden accession of diarrhoea, with abdominal tenderness, and an increase of typhomania. The discharges are very peculiar, frothy, illy concocted, and have a very unpleasant cadaveric odor. The tongue is moist, and shows a very dirty coat. The symptoms are very grave. Prescribe-R Sulphurous Acid, Simple Sirup, aa. 3j.; a teaspoonful every three hours. R Tinct. Aconite, gtts. x.; Tinct. Ipecac, gtts. xx.; Water, Živ.; a teaspoonful every hour for two hours, the third hour the acid; Quinine inunc- tion to abdomen. Must maintain the recumbent position. The treatment served the purpose, the diarrhoea was checked, and by the third day the patient was taking his milk kindly, and convalesced the fourth week. CASE XLIII. Continued Fever, with Disease of Peyer's Glands-Typhoid.-O. M—, æt. 18, is in the third week of typhoid fever with Homoeopathic practice, and is "given up" as incurable. Condition.-Lies on the back continually, picks at the bed clothes, muttering delirium, face and eyes congested. Tongue, fauces and pharynx swollen, and of a deep purplish color, dark brown, nasty coat on tongue, bowels tympanitic, stools dark and excessively fetid, pulse 130, without strength, tem- perature 105 evening. Prescribed-B Baptisia Tinctoria in infusion, a teaspoon- ful every two hours, also wash the mouth with it. B Tinct. Aconite, gtts. v.; Tinct. Belladonna, gtts. x.; Water, 3iv.; a teaspoonful every two hours. Use an acid bath (muriatic) with Quinine. On the third day of this treatment there was decided improvement, the diarrhoea checked. Now added 344 SPECIFIC MEDICATION. Muriatic Acid internally, and continued to convalescence on the twenty-sixth day of the disease. CASE XLIV.-Continued Fever, Typhoid, with Retention of Urine.-M. C— is in the second week of typhoid fever. The typhomania has been a marked feature, and is now sink- ing to a muttering delirium. Muscular feebleness has been especially marked, and now the patient lies on the back and slips toward the foot of the bed. On the morning of the thir teenth day found retention of urine, and difficulty in respira- tion. There has been seemingly an indication for an acid treat- ment in the deep-red of the tongue and mucous membranes. The feeble pulse and tendency to congestion seemed to call for Aconite and Belladonna. But the treatment thus far has been a failure, and unless something more is done the patient will die. Drew off the urine with catheter, and prescribed: R Solu- tion of Strychnia, 3j.; Liquor Bismuth, 3iv.; a teaspoonful every three hours. Add Bicarbonate of Potash to water, so that it will be pleasant to take and use as a drink; a weak lye as a bath once daily. There was marked improvement within twenty-four hours, and the patient convalesced, with- out change of remedies. Here was one of those rare cases in which, though there was an alkaline condition, there was a want of Potash as shown by the extreme muscular feebleness, and the salt of Potash became a true restorative; whilst Strychnia increased innervation from the spinal cord and sympathetic, and was just what was needed to increase the strength of the circula- tion and respiratory movement. SMALLPOX. 845 Smallpox. There are three features in this disease that demand par- ticular attention: 1, The disease is exhaustive; 2, there is impairment of the function of the skin; 3, there is the ten- dency to blood poisoning-sepsis. If we neglect to provide against these, in severe cases we may have death result from any one of the three. We say, therefore: That we must keep the stomach and in- testinal canal in good condition for the reception of food, and for its digestion; and see that the patient has it frequently and in proper form. That under no circumstances must the eruption be determined to the skin so as to impair its func- tion to the amount of five-sevenths. That in all cases the patient be protected against blood poisoning, and that the proper antiseptics be continuously used. I recognize the fact that the same pathological laws govern this as other fevers, and that therapeutic means are quite as definite and certain. As is the frequency of pulse and in- crease of temperature, so is the severity of the disease- marked by arrested secretion, impaired digestion, derange- ment of the nervous system, blood-poisoning, and extent of eruption. As we follow the ordinary indications in the treat- ment of a fever-bring down the pulse, lessen the tempera- ture, establish secretion, and support the strength, the disease becomes mild, and the eruption discrete. I propose, therefore, the use of the proper sedatives, the bath, alkaline diuretics, and occasional laxatives, and the proper antiseptics, with good feeding, as a rational treatment of smallpox. I claim that with this treatment, the disease may not only be rendered much milder, but in some cases may be aborted, as I have conclusively proven in my practice. The ordinary treatment of this disease is radically wrong, and is in part the cause of its fatality. As is well known, it consists in the frequent and continuous use of purgatives, and stimulant means to determine the eruption to the skin. The one impairs the action of the intestinal canal, the other the 346 SPECIFIC MEDICATION. function of the skin. Both are absolutely prohibited in my treatment, under all circumstances. I may also say that the patient can not bear the use of the large doses of Veratrum named in the books, and a fatal result may be readily ob tained with this. CASE XLV.—M- a member of the present class was attacked in the following way: Had suffered for three days with a sense of depression, aching in back and limbs, and loss of appetite. Then a well marked chill, followed by high fever. When I was called, found the pulse full and hard, 120 per per minute; skin dry and hot, face .flushed, eyes bright, tongue pallid and coated from base to tip with a very nasty white coat; throat much swollen, showing a bluish pallor; is very restless and can not sleep, no appetite. Ordered-Add Bicarbonate of Soda to water to make a pleasant drink, and give him all he wishes. R Tinct. Vera- trum, gtts. x.; Tinct Gelseminum, gtts. xx.; Water, 3iv.; a teaspoonful every hour. Found the next morning that he had taken the Soda water by the pint, and that it had passed off freely by the bowels. The pallor of mucous membranes was replaced by deep red- ness, the pulse was 90; patient better in every respect. Con- tinued the sedative, and ordered for the day diluted Muriatic Acid as a drink. The third day from chill, the eruption commenced making its appearance, and the next day covered the body as thickly as I ever saw it in the severest confluent form of the disease. • On the fourth day, Sulphurous Acid was given as the anti- septic, the Veratrum being continued. And this was the treatment so long as any was needed. The eruption in the throat was as severe as ever I witnessed it, and the discharge from the mouth excessive. The eruption on the face did not fill, neither did it on many parts of the body. Medicine was suspended the eighth day. SMALLPOX. 347 CASE XLVI.-Confluent Smallpox.-L. S., confluent small- pox of severest type. Throat symptoms very marked, and secretion of mouth and throat abundant and offensive. The odor of smallpox is so strong that it permeates the entire house, and is almost unendurable in the room. It is now the fifth day from the chill; the patient has been in the hands of another physician, and doctors are changed because it is im- possible for him to take medicine. Has had purgatives every day and various nasty potions. The one favorable feature is- the eruption is out, though the skin is dusky. Find it abso- lutely impossible for patient to take medicine or food; the stomach would not tolerate it, and the patient can not swallow it. and a Treatment-Have the stove taken out of the room, fire built in the open fireplace; one window being opened to give free ingress of air. The room thoroughly cleaned, the patient washed, and clothing of person and bed changed. Let the mouth and throat be washed with salt water suffi- ciently often to free it from the secretions, and give small por- tions of a weak salt water as a drink. Burn a small portion of Sulphur by the bedside every three hours. Wash the patient thoroughly with soap and water every day. On the second day the patient was able to take food, and . from the third day on he took corn meal gruel and milk freely. The unpleasant odor had nearly disappeared the third day, and the septic symptoms rapidly abated. The patient made a good convalescence in the usual time, no medicine having been given. A I give this as a marked example of the benefit to be ob- tained from antiseptic treatment. The agent here was Sul- phurous Acid, set free by burning Sulphur. It influenced the contagion directly, and its inhalation was quite as efficient in checking the blood poisoning as if it had been given by mouth. CASE XLVII.-Confluent Smallpox.-N., æt. 5, never vac- cinated, has had severe fever four days, with the pain, full- 848 SPECIFIC MEDICATION. ness of skin, throat symptoms and peculiar odor that indicate smallpox. The skin is flushed and dusky, the patient coma- tose. Prescribed-B Tinct. Aconite, gtts. v.; Tinct. Belladonna, gtts. x.; Water, živ.; a teaspoonful every hour. In twelve hours the nervous system was freed, the patient conscious, and the eruption coming out nicely. Sulphite of Soda, the antiseptic indicated, was prescribed in addition, and with cleanliness, the use of the bath, and fluid food, the patient convalesced at the usual time. CASE XLVIII. — Confluent Smallpox.-C. is now in the seventh day of the disease, eruption out and filling. Pulse is small and hard, 120 beats per minute, temperature 106°. Skin dusky, eruption dark colored, mouth dry, tongue almost black, sordes on teeth, has been delirious since the third day. Prescribed-R Dilute Muriatic Acid, 3ss.; Simple Syrup, 3jss.; a teaspoonful every two hours in his drink. R Tinct. Aconite, gtts. xx.; Tinct. Lobelia, gtts. xx.; Water, 3iv.; a teaspoonful every hour. Fluid food with a small portion of Brandy every three hours, and Quinine inunction to the ab- domen. Lived through it, and made a good convalescence. Measles. If I was writing for the profession at large, I would proba- bly say-dispense with all medicines—and leave the case to nature, aided by such simple teas as are given in most house- holds. For here, it is very certain, the mortality is in pro- portion to the amount of medication, and it is much better to dispense with the physician when there is real need for aid than have the ordinary routine of treatment. were CASE XLIX.-Rubeola.-Four children of Mr. attacked with measles in January. Two of them had it quite severely, the temperature in one marking 109°. There was MEASLES. 849 more than the usual bronchial irritation in all, and in one it was very severe. In two of the cases there was oppression of the nervous system, and a tendency to sleep all the time before the erup- tion. For these I prescribed: R Tinct. Aconite, gtts. v.; Tinct. Belladonna, gtts. viij.; Water, 3iv.; for a girl of eight years, a teaspoonful every hour; for a child of four, half a tea- spoonful every hour. The others had: R Tinct. Aconite, gtts. v.; Tinct. Ipecac, gtts. xv.; Water, 3iv.; a teaspoonful eyery hour, until the fever abates; and this was given to the first two when the eruption had appeared. In but one, was it necessary to give anything special for the cough, and here an infusion of Red Clover answered the purpose well. In the majority of cases of simple rubeola I prescribe: R Tinct. Lobelia, (seed), gtts. x.; Tinct. Asclepias, gtts. xx. to xxx.; Water, Ziv.; a teaspoonful every hour, Keep the patient quiet in bed, but not too warm. If need be, a seda- tive may be added to the medicine if the fever runs high. CASE L.-Rubeola--Tardy Appearance of the Eruption- Coma.-S—, æt ten years, has been exposed to measles, has the unpleasant appearance of the eyes, and the bronchial irri- tation so characteristic of the disease; is now the third day from attack. Skin dry and harsh, temperature high, pulse 140, has been unconscious for some six hours. Prescribed-B Tinct. Aconite, gtts. v.; Tinct. Belladonna, gtts. x.; Water, 3iv.; a teaspoonful every hour. The child gradually regained consciousness, though the eruption did not appear until the fifth day. After which small doses of Lobelia and Asclepias controlled the bronchial irritation. CASE LI.-Rubeola Maligna-Coma.-Was called to see B, æt. nine years, in a Fifth Street boarding house—all the surroundings bad. Is now in the seventh day of the dis ease, eruption has not made its appearance, has had two phy- sicians who have given him up. Has not been conscious for three days. 850 SPECIFIC MEDICATION. Symptoms now: Pulse 120, oppressed, skin turgid and dusky red, face swollen, eyes reddened, breathes with difficulty from pulmonary congestion. Ordered from the nearest drug store Acetous Emetic Tinc ture of the Dispensatory, and Compound Powder of Lobelia Made au infusion of the last, and at once proceeded to ad minister them alternately, in small doses frequently repeated. In an hour, the stimulant influence was distinctly marked in an improved circulation and respiration. Thorough emesis in two hours, with speedy relief to the nervous system; and the patient was conscious, the eruption appearing freely in eight hours from first administration. Put the patient upon the use of: R Tinct. Lobelia, gtts. x.; Tinct. Asclepias, gtts. xxx.; Water, 3iv.; a teaspoonful every hour. Made a good recovery. CASE LII-Rubeola Maligna.-Prof. Jones' Cases of Black Measles.-Two brothers by the name of Baird, from Mason, Tenn., attending the Spring course of 1871, became sick, and after treating themselves for three or four days, sent for me. They were boarding themselves, and being alone in the room, had no attention. Found the eldest brother sitting in his shirt and drawers, in a cold room, trying to build a fire, his face presenting that peculiar dark mottled appearance we observe after recovery from smallpox. Examination determined that it was measles, and a very unpleasant condition. Both cases were nearly alike-pulse 130 to 140, small and oppressed, eruption dusky, tongue dark red, dry, and covered with a brownish fur, sordes on teeth, cough very bad and expectorating largely a muco- pus-to the amount of a pint or more in twenty-four hours. Prescribed-B Dilute Muriatic Acid, 3j.; Simple Sirup, Zij.; add to water to make a pleasant drink and give treely. R Tinct. Aconite, gtts. x.; Tinct. Asclepias, 3ss.; Water, ziv.; a teaspoonful every hour. One showing a marked op- pression of the nerve centres, and tendency to congestion, had Belladonna in place of the Asclepias for two days. * MEASLES. 851 Their fellow students were very kind as soon as their situs- tion became known, and kept the room of uniform tempera- ture, and saw that they had food. We gave boiled milk and beef tea freely. Both convalesced well, and have had no sub- sequent trouble CASE LIII.-Rubeola Maligna.—M æt. 23, has had a chill, followed by high fever, a harsh dry cough, suffusion of eyes, with fullness and redness of skin. Now, the third day, the eruption shows itself, but does not come out freely. Prescribed-Tinct. Aconite, gtts. x.; Tinct. Ipecac, gtts. xxx.; Water, 3iv.; a teaspoonful every hour. A hot foot- bath and a cup of hot sage tea. Saw him the next day-worse. The surface is somewhat dusky, eruption scant, tongue excessively dry. Prescribed in addition R Sulphurous Acid, 3j.; Simple Syrup, 3ij.; a tea- spoonful every three hours. The unpleasaut symptoms faded away rapidly, the eruption appeared, and the patient conva- lesced well. CASE LIV.-The Cough of Measles.-A child of my own had measles during one of the severest endemics we ever had in this city, and as a sequel, had that persistent irritation of bronchii with cough, which is so unpleasant and so frequently fatal. After an ineffectual use of the ordinary means, put her upon the use of: R Tinct. Drosera, 3ss.; Water, 3iv.; a teaspoon- ful four times a day. Was entirely relieved in a week or ter days, and though the cough would return with every slight cold, for a year following, it was always speedily checked by the same remedy. I have used the Drosera in scores of cases with like results, and now never think of prescribing anything but this or an infusion of Clover Hay. 352 SPECIFIC MEDICATION. Rheumatism. The reader will notice that I do not propose to prescribe for the name rheumatism, any more than I would prescribe for the name "bilious fever." The cases of rheumatism only agree in one thing-the character of the pain; and as we have long since learned, pain is only a symptom, and never to be prescribed for as the disease. The reader may suggest, however, that writers agree that rheumatism is dependent upon the generation of lactic acid in excess, and that the deposit of this in the tissues is the cause of the local inflammation. And if so, surely the alka- line treatment so generally recommended, must be the treat- ment. Whilst I admit the probability—that some product of re- trograde metamorphosis, either of food or tissue, is the mate- ries morbi in this disease, I am very sure it is not lactic acid; and you will readily come to this conclusion if you will care- fully read your Carpenter, Huxley or Draper. And I am quite as sure that there is in some an excess of alkalinity, in others an excess of acid, and in still others neither the one nor the other. - CASE LV.-Inflammatory Rheumatism. — A. S., æt. 46, rheumatic diathesis, will have averaged an attack a year, for five years, running the usual course in about six weeks. Was called to attend him the third day of this attack-symptoms as follows: Tongue clean, mucous membranes of normal color; bowels regular; pulse 110, full and oppressed; some difficulty in respiration, and oppression in præcordia, requires to be propped up in bed; the disease is localized in right knee, which is very much swollen, very painful, and exquisitely tender to the touch; the most prominent symptom, as well as the most singular one, is the constant profuse sweating. Prescribed-B Tinct. Aconite, gtts. xx.; Tinct. Macrotys, 3ss.; Syrup, 3ijss.; a teaspoonful every two hours—no effect RHEUMATISM. 853 only a severe headache. The next day he was put upon the use of alkalies, giving them freely in the form of Bicarbonate of Soda and Acetate of Potash - patient growing worge. With two days of this treatment changed to lemon juice, and gave Veratrum as the sedative-amendment for one day, and then a relapse. Sixth day of treatment gave Colchicum- English Wine, gtts. v. every two hours. Seventh day patient much worse. Colchicum has acted upon the bowels freely, and his stomach is irritable; sweating stopped whilst bowels were acting, but is now worse than ever. Eighth and ninth days a placebo; patient is suffering intensely, and talks of changing doctors. All this time we have been assiduous in making applications to the inflamed part, changing them from day to day, so that we have run through the entire list. Reading up the treatment of phthisis a few weeks since I noticed the recommendation of a diaphoretic for night- sweats have tried it in one case with advantage-why not give a diaphoretic for this prodigious sweating. And so I order that the patient be put between blankets, thoroughly rubbed down with dry flannel whenever the skin becomes wet, and give a strong infusion of Asclepias in tablespoonful doses. There was a decided amendment the first day, and by the fifteenth day of the disease the patient was convalescent. CASE LVI.-Inflammatory Rheumatism.-George C., æt. 15, rheumatic diathesis, has had three very severe previous attacks, the last confining him to his bed ten weeks, and leav- ing serious structural heart disease-treatment Eclectic. Symptoms as follows:-Now the third day; high fever; pulse 110, full and bounding; skin dry as parchment; urine scant and high-colored; bowels constipated; no appetite; mouth dry; mucous membranes natural as to color; tongue showing a clear white coat; is suffering intensely in one knee and ankle, the parts swollen, exquisitely tender and present- ing evidences of active inflammation. Prescribed-B Tinct. Veratrum, gtts. xx.; Tinct. Macrotys, gtts. xxx.; Water, 3iv.; a teaspoonful every hour. Acetate 30 354 SPECIFIC MEDICATION. of Potash added to his drink in small quantity. Put the patient between blankets, wrap the inflamed parts in flannel and let them alone. There was a gradual amendment, and the patient was con- valescent by the ninth day, though the parts were weak, and he did not get out of the house until the third week. But what was most singular, the old heart disease was so im- proved, that he was comparatively free from suffering in this respect, and the improvement continuing for some months, even the marked saw-sound faded out, and to-day his heart does its work well, with scarce a trace of disease. CASE LVII.-Inflammatory Rheumatism.-Joseph B., æt. 41, is now in the second week of an attack of rheumatism, the disease growing worse from day to day. Has had a Col- chicum treatment with Mercury, with the common applica- tions to the affected part. Symptoms are all severe, but the one most pronounced, and which indicates the line of treatment is-marked pallidity of mucous membranes, broad pallid tongue, pitting where it comes in contact with the teeth, and covered with a white pasty coat. Prescribed-Bicarbonate of Soda added to water, and give freely as a drink. Inflamed parts to be wrapped in raw cotton. Marked amendment in twenty-four hours, and patient rapidly convalesced. No other remedy was given. CASE LVIII.-Inflammatory Rheumatism.-K., æt. 30, rheumatic diathesis, has lain for six or eight weeks in these attacks; presents the usual symptoms, disease located in lum- bar region extending to hip. Prescribed-R Tinct. Aconite, gtts. x.; Tinct. Macrotys, 3ss.; Water, 3iv.; a teaspoonful every hour. Tongue shows a slight increase of redness; for which give lemonade. Fever abates, and by the third day patient is apparently comfort- able. Going on to the sixth day, there is a relapse, worse than at first. RHEUMATISM. 355 Notice a peculiar puffiness of hands and face, skin glisten- ing, and for this give in addition to Aconite and Macrotys : R Acetate of Potash, 3ss.; Tinct. Apocynum, gtts. xx., Water, Zij.; a teaspoonful every three hours. Improves slowly, and the third day from this, drop the Acetate of Potash and give him Apocynum and Macrotys. Made a good recovery by the end of the week. CASE LIX.-Inflammatory Rheumatism.-J. R. has been suffering from inflammatory rheumatism for more than three weeks; one of the worst cases I ever saw. Have treated him myself, and been assiduous in attention, using all the reme- dies recommended in such cases. Medicine has invariably made him worse, feels more comfortable when nothing is taken. It is many years since, and just at that time Lemon Juice was recommended for rheumatism. Concluded to try it, but without any faith in its virtues, and gave it as freely as the patient could take it. There was amendment from the first, and before the end of the week he was very comfortable, and made a good recovery. You ask me what was the indication for the Acid? I an- swer, that I don't know. I was treating names at that time, and my patient had "rheumatism." I have not had a case of rheumatism in the past four years, in which the indications for an acid treatment were so marked, that 1 would have selected an acid alone; but I am sure I have had them in the earlier years of my practice. CASE LX.-Sub-Acute Rheumatism.-M., æt. 35, of rheu- matic diathesis, has been suffering since early Winter with sub-acute rheumatism. It shifts its position, and has affected most of the small articulations. There is slight oedema of the feet, and general puffiness of the skin, which presents a peculiar glistening appearance. Prescribed-B Tinct. Apocpnum Can., gtts. xx.; Water, ziv.; a teaspoonful every two hours. Improved steadily 356 SPECIFIC MEDICATION. from the first, and the second week added Tinct. Nux Vomica, gtts. x.; taking the medicine every three hours. Was en- tirely free from the disease the third week. CASE LXI.-Sub-Acute Rheumatism.—-Chas. O. is suffer- ing from a recent attack of sub acute rheumatism. Two weeks since he applied for treatment for pain in the chest- costal rheumatism. Now it is located in the wrist and one phalangeal articulation. Prescribed-B Tinct. Aconite, gtts. x.; Tinct. Macrotys, gtts. xx.; Water, 3iv.; a teaspoonful every hour. The pain in the chest was removed with four doses of medicine, but the last attack required three days treatment. I will not attempt to illustrate the treatment of chronic rheumatism, because it would be occupying space without ad- vantage to the reader. It is especially difficult to describe a case of chronic disease, occupying some weeks of time, so that the reader can see the relation between symptoms and remedies. In adddition to what has been pointed out, I may say, that we especially study the function of digestion and blood-mak- ing, and retrograde metamorphosis and excretion, for in some lesion of one of them we will probably find the disease con- stantly reproducing itself. See that the act of digestion is properly performed, and that no morbid product is introduced into the circulation from the digestive apparatus. Then see that the waste of tissue goes on in a normal manner, and that all its products are removed as speedily as possible. INFANTILE PNEUMONIA. 857 Infantile Pneumonia. CASE LXII. - Infantile Pneumonia.-L., æt. four years, has been sick four days. The first day seemed to have a bad cold, the second had a chill, followed for two or three hours by fever. The third had a chill, followed by fever, which has continued up to the present in a remittent form. Both lungs are involved to a considerable extent, and the cough is harassing, sputa slightly "rusty." Pulse full and open. • Prescribed-B Tinct. Veratrum, gtts. x.; Water, 3iv.; a teaspoonful every hour until the fever abates, then in half- teaspoonful doses. Apply to the chest a cloth spread with lard, and sprinkled with Comp. Powder of Lobelia. Conva- lescent with four days of treatment, the inflammatory action being arrested the first twenty-four hours. CASE LXIII.-Lobular Pneumonia, with Asthenic Bron- chitis.-N., æt. six months, has been sick for a week, gradu- ally growing worse. Has a rattling cough, difficult respiration, remittent fever. Now seems very much prostrated, pulse small and frequent, no hardness; when the fever is on the child is very restless, when it goes off it seems exhausted. Mucus accumulates, and makes the breathing very difficult. Prescribed-B Tincture Lobelia, 3j.; Compound Tincture of Lavender, ziij.; Simple Syrup, 3jss. M. Give in small doses (teaspoonful) every few minutes at first, then at inter- vals of an hour. The same local application to the chest as above. In this case I gave the old formula. Now I very frequently add the Tincture of Lobelia Seed to water, and give it in the same manner as Veratrum and Aconite. CASE LXIV.—Infantile Pneumonia.-G., æt. three years, has been sick but two days, yet looks to have been sick a week. Skin very dry and harsh, hot; pulse 130, small and sharp; tongue contracted and dry; a very persistent, dry, hacking cough; crepitation over a greater part of both lungs. Prescribed-R Tinct. Aconite, gtts. viij.; Tinct. Ipecac, 358 SPECIFIC MEDICATION. 3ss.; Water, 3iv.; a teaspoonful every hour. The plaster of Lard with Emetic powder to the chest. Was very sick for two days-breathing difficult. Amendment commenced the third, and the child was convalescent by the sixth. No other remedies were given. This is a very common plan of treatment with me in these cases, and it is rare to find one that does not yield readily · CASE LXV.-Infantile Pneumonia, with Congestion.-S., æt. four years, has been sick twenty-four hours. Disease commenced with a well marked chill, fever of an asthenic character following. The child is semi-comatose, sleeps with the eyes part open, eyes dull and pupils dilated; the toes are cold; pulse 120, soft and easily compressed; cough in parox- ysms, rattling, but no expectoration; an unpleasant rattling, blowing sound heard over the larger portion of the chest- the posterior part of the lung on right side is free. Had a chill the second day, and again the third day. Prescribed-B Tinct. Aconite, gtts. x.; Tinct. Belladonna, gtts. x.; Water, 3iv.; a teaspoonful every hour. · Quinia in- unction-R Quinia Sul., 3j.; Adeps, 3ij.; Oleum Anisi, gtts. xx. M.-twice daily to be throughly used. Emetic powder and lard to chest. The comatose symptoms were removed the first twelve hours, the chill of the third day was lighter, and the child was convalescent by the fifth day. CASE LXVI.-Infantile Pneumonia, with Determination to the Brain.-A., æt. twenty months, seemed to have had a bad cold for a couple of days, the third day a very high fever came up suddenly, the child being extremely restless, and had a convulsion. Was called at this time. Found the skin hot- not dry, pulse 140, sharp, mouth not dry but very red, eyes bright, intolerant to light, pupils contracted to a point. A very harassing hacking cough, respiration somewhat labored and abdominal, small blowing sounds when the ear was ap- plied to the chest. CHOLERA INFANTUM. 359 Prescribed-B Tinct. Veratrum, gtts. x.; Tinct. Gelsemi- num gtts. xxx.; Water, 3iv.; a teaspoonful every hour. Same local application to the chest as before. The unpleasant symptoms gradually yielded, and the child was convalescent on the fourth day of treatment. I think these cases will illustrate pretty well the more fre- quent departures from the ordinary standard of infantile pneumonia, and the treatment necessary for the special forms of the disease. I have employed these remedies in this way for the ten years past-some of them for a longer time-and as they have not failed me when I have done my part to make a correct diagnosis, I recommend them to others with great confidence. Cholera Infantum. CASE LXVII.-Cholera Infantum. — M., æt. twenty-two months, is suffering from acute cholera infantum of three days' duration. Evacuations frequent, greenish, and attended with some tenesmus. Nausea with occasional vomiting; not as much thirst as is usual in the disease. A rare symptom in this disease, the pulse is very full and strong, ranging from 100 to 110 beats per minute. I take the condition of the pulse as the key-note of the treatment, and prescribe-R Tincture Veratrum, gtts. x.; Water, 3iv.; given in teaspoonful doses every hour until the fever declines and the patient is better, then half-teaspoonful doses. No other remedy was given. There were but two dis- charges the third day; the fever had entirely disappeared. Ordered Quinine inunction once daily, and up to this time, the fourth week, there has been no return of the disease. CASE LXVIII.-Cholera Infantum.-C., æt. twenty-eight months, has had diarrhoea since April, been treated by two physicians, always worse when taking medicine. Skin sallow, relaxed and doughy; extremities cold, pulse soft, and easily compressed; tongue pale and covered with a 860 SPECIFIC MEDICATION. dirty yellowish fur in streaks; vomits a yellow, unpleasant fluid mixed with mucus; discharges from the bowels mucoid, with a trace of pus and broken down blood. Prescribed-B Triturated Podophyllin, 1-100th, one grain every two hours. Quinine inunction twice a day. A milk diet, care being used that the milk be sweet and good, and to which is added about ten grains of Phosphate of Soda in the twenty-four hours. The child made a good recovery in two weeks, the amend- ment dating from the second day of treatment. I say the child made a recovery-for it is now eating well, gaining flesh, is walking, and plays with spirit, yet there is no doubt but it will have occasional slight attacks until cold weather. CASE LXIX.-Cholera Infantum.-S., æt. two years, has had diarrhoea, thirst, and nausea and vomiting for three weeks, gradually increasing. Has taken Neutralizing Cordial, Bismuth, Ipecac, Hydrarg. Cum Creta, and astringents, with- out any good results-or rather with bad results, for the medicine has increased the disease. Find on examination that the bowels are camid, especially in hypochondria; there is umbilical pain at umes, the skin is sallow and relaxed, the face especially is a sallow yellow, the tongue full, pale, and slightly dirty. Prescribed-R Tinct. Nux Vomica, gtts. iij.; Water, 3iv.; a teaspoonful every hour at first, then every two and three hours. The child made a good recovery in a week, no other remedy being given. CASE LXX.-Cholera Infantum.-F., ac. twenty months, has had cholera infantum some nine weeks, is very much re- duced, and the attending physician thinks recovery impossi- ble. The evacuations from the bowels are copious and watery, some six or eight in the twenty-four hours; there is occasional nausea, such as would be produced by tickling the fauces, and the milk is almost uniformıy thrown up after nursing. DYSENTERY. 361 There is one special feature-the child is dull and somno- lent, the eyes dull and the pupils somewhat dilated and im- mobile. The pulse is soft and easily compressed, the abdomen tumid with evident congestion of the portal circle. Prescribed-B Tinct. Aconite, gtts. iv.; Tinct. Bella- donna, gtts. x.; Water, 3iv.; a teaspoonful every two hours. Amendment was perceptible the next day; the remedy was continued the first week, and then changed for small doses of Ipecac. The child made a good recovery.. These six cases will illustrate the specific treatment of cholera infantum or summer complaint. In ninety-five out of one hundred cases, the treatment will require but the three remedies, Ipecac, Aconite and Nux Vomica, one or more, but there are a few cases that require other means, and when specially indicated, we find they not only relieve the special symptoms, but the disease in its totality. Dysentery. CASE LXXI.-Dysentery.-G., æt. eight months, had diar- rhoea, commencing in the morning, but in the evening the stools became small and bloody, attended with pain and tenesmus. Pulse 130 and hard, surface hot, very restless, nausea with occasional retching. Discharges about every ten minutes. Child regarded by the parents as in a dangerous condition, one having died in the same house from the same disease the week before. Prescribed at 11 P. M.-R Tinct. Aconite, gtts. v.; Tinct. Ipecac, gtts. xv.; Water, 3iv.; a teaspoonful every hour. No dysenteric discharges after 4 A. M. the next morning, and the child was well the second day. CASE LXXII. - Enteritis with Aphtha. Mary N., æt. seven months, was taken to church to be baptized during the cold spell the first of June. The child was considerably ex- posed, and the rector used water rather freely; the result a 81 362 SPECIFIC MEDICATION. severe cold with diarrhoea, and the third day a severe aphthous sore mouth. Fever is constant-pulse ranging from 120 to 150 as the fever rises and falls: skin dry and harsh; discharges from the bowels profuse, greenish, and attended with pain; mouth hot and red; tongue red and partially coated; papillæ red and clongated; aphthous patches well defined and a clear pearly- white. Altogether the patient is very sick, and in the olden time the prognosis would have been very unfavorable. Explained to the mother the character of the diarrhoea- that it was caused by inflammation of the small intestine, and that hence it would not do to check it suddenly-and that the sore mouth was but a symptom of the intestinal disease. Prescribed-Tinct. Aconite, gtts. iij.; Tinct. Ipecac, gtts. v.; Water, 3ij, (to be kept on ice); half a teaspoonful every half hour. Also, R Tinct. Nux Vomica gtts. j.; Water, 3ij.; to be given in teaspoonful doses as often as necessary to re- lieve the pain. Slight amendment the second day, the discharges the same, but the fever not so high, and the pain controlled by the Nux. Not much change the third day, except that the aph- tha was slowly disappearing-difficulty thus far in persuad- ing the friends that mouth washes were unnecessary. Added to the treatment Quinine inunction twice daily. The diar- rhoea still continues the fourth day, but there is no pain or tenesmus, the fever has disappeared, the sore mouth is nearly gone, and the child is commencing to take milk and digest it. Thus the case progressed with gradual amendment until the discharges became natural about the tenth day, and the child had a perfect recovery. But the father could not see why the diarrhoea should not be arrested at once, and was extremely anxious that large doses of some of the older remedies should be tried. Afterwards he expressed satisfac tion that his solicitations were refused. HOW SHALL WE STUDY MATERIA MEDICA? IN publishing a fifth edition of this little work, I have thought it best to present the substance of the papers recently published in the Eclectic Medical Journal-" How shall we study Materia Medica?" Every reader is interested in this study, and I have no doubt desires to make original investiga- tions. At least he desires to know the methods of study pur- sued in specific medication, that he may better weigh the re- sults given, and prove their truth, if necessary. (( Every physician should be in a condition to prove all things," and should never accept results, no matter by whom given, unless they will bear a rigid examination. That he may form an intelligent conclusion, it is necessary that he have before him the methods pursued, as well as the results. In this connection I may say that no amount of facts, as facts alone, will advance the science of medicine. Men may observe for hundreds of years, and if it ends with simple ob- servation, but little advance will be made. We hear a great deal said about clinical medicine, clinical teaching, and clinical observation, and yet I am free to say that medicine has not made the progress through these methods that many have sup- posed. Advance in medicine, as in everything else, comes from the mind within and not from the world without; is the result of brain-work, and not from impressions on the organs of special sense. I am assured that this will be disputed at once, yet I ask the reader to think the matter over without prejudice, and with the discoveries of the day before him, and he will reach the same conclusion. 364 SPECIFIC MEDICATION. The steam-engine was built in the brain before it took form n iron. The steamboat had taken form in Fulton's mind, before it had a commencement in fact. So was the spinning- jenny with Arkwright, and the electric telegraph with Morse, evolved from the mind and not from the machine shop or lab- oratory. And yet I would be the last one to depreciate experiment, or the advantage of observation, and the accumulation of facts. These are good if rightly used; good if properly classified and subject to the mind; not good if allowed to exert an undue control and govern the processes of thought. We use facts to reason from, and experiment to guide and prove the action of the mind. But we should not commence any investigation with a prejudiced mind, for in such case neither is the reason free or observation exact. Freedom from prejudice or bias is then the first requisite of these studies we are making, and the man who can not free himself from prejudice will always be a follower, never a leader in original investigation. So much as a necessary preliminary. We want facts-di- vested of bias-to reason from. We want the action of the mind, from facts to principles, guided by experiment, and the results proven by experiment. The first proposition we make is-That causes of disease act upon the living body, and their action is invariably to im- pair this life. Causes of disease are to be removed, when this is possible, and when it can be done without a still further impairment of life. The disease itself is a wrong in the life of the individual, and is.as much a part of him as is healthy life at other times. Disease is opposed by remedies which influence the organ- ism toward a healthy or right performance of its functions. Remedies. then, may be divided into two classes: (a) Those which remove causes of disease. (b) Those which restore vital processes STUDY OF MATERIA MEDICA. 365 In taking up an individual agent, one probably that has been employed in medicine for a long time, we get from published works what seem to be the facts with regard to it, and clas- sify them as above-to remove causes of disease-to influence vital processes. The mind very soon separates them, and with- out our volition will have weighed the facts, found some of them wanting, and thrown these out, others imperfect and with a wrong meaning, others that have not had sufficient atten- tion, etc. As the process of analysis goes on, it not only discusses probabilities, but wants to know how the results have been obtained. In the case of a remedy proposing to remove causes of diseases, it wants to know how it is done. Is it a chemical influence, combining with and neutralizing the cause, or does it extract it, as in pulling a thorn, removing a decayed tooth or a sequestrum, or is some organism forced to its removal, as when we produce emesis, catharsis, diaphoresis, diuresis, in- creased combustion, etc. Immediately the mind turns to the result of such actions. How is the life of the individual influenced by such extraction or removal of disease. A man has taken Caustic Potash- what will be the result from a sufficient quantity of Sulphuric Acid to neutralize it? How is the life of the individual influ- aped by emetics, cathartics, diaphoretics, etc. Removing the cause of disease is a very good thing in some gases, a very bad thing in others. Good, when it can be done without too great impairment of life; bad, when it necessitates marked derangement of function, and impairment of life. Does the remedy propose to influence the life, and thus re- store health, the mind at once asks how? Is it general or local in its action? Does it increase the viability of the sick, and thus enable the body to perform its functions better? Does it sustain life directly, by furnishing material needed for nutrition, or for other purposes in the economy? Does it rectify wrongs in the circulation, innervation, waste and nutrition? 366 SPECIFIC MEDICATION. These are a few of the questions that the mind asks, and an- swers. Not of itself of course, but as the facts are presented and analyzed. A few hours of careful study in this way works wonders with a man's Materia Medica. Things that he had accepted as true lose their basis and fade out; whilst other and more rational views take their place. Guided br experimentation— We commence by gathering together the materials at our disposal, and we analyze and weigh them as indicated above, and reach certain conclusion from the premises. It does not do to dogmatize as yet, we have only commenced the investi- gation. We bring all our previous experience in therapeutics to aid us, and we proceed to prove the truth of our conclusions by direct experiment. The course of experimentation must vary in different cases, must indeed be varied in order to reach definite results, and in all cases must be conducted with care. We can not jump at conclusions here. We are dealing with a living body, and one which possesses recuperative power in an eminent degree. We should be making very great mistakes if we regarded every thing that followed the administration of a drug, as its direct result, and yet we are constantly in danger of making such mistakes. A man had his child vaccinated, and the next day it fell out of a fourth story window and broke its neck-he gravely remarked that nothing would induce him to have another child vaccinated. (?) In the above remarks I have endeavored to show the method of getting old remedies before us for investigation, and the advantages of thought in the study of Materia Medica. The judicial mind is one element of success. Without prejudice we propose to weigh all the evidence, and compare it with our past experience, and our present physiological and pathological knowledge. It is nothing to me if there is no word of truth in the long statements, or if the grain of truth is so covered up that it is not generally seen. STUDY OF MATERIA MEDICA. 367 Such analysis is the commencement of a right study, and is a necessary preparation for subsequent investigation and ex- perimentation. We want a“right habit of thought,” and a feeling of freedom from the authorities, that may be obtained better by this study than by any other. It is well enough to know how remedies act—at least to a certain extent. We want to know whether the action of a rem- edy is topical or from the blood; and whether it is directly upon the affected part, or indirectly through its action upon other parts or functions. It is well also to know whether it influences the life directly by its influence upon the body, or indirectly by the body's action upon it for removal—whether in the present condition the remedy is an advantage to the life, or a toxic agent. The questions also arise, is the action chem- ical? physical? vital? The simple proposition" disease is a departure from health,”—is followed by the pathological question—“in what direction is this departure"?"—and this by the therapeutic con- clusion, that a remedy is that which, "opposing" such depar- ture, brings the part or function to a healthy standard We want to know the action of drugs in medicinal doses, upon the human body; not only so far as this action is elective for different parts, but also as to its kind. If a drug is elective for the apparatus of circulation, in- nervation, digestion, nutrition, etc., we think of it as among the possible remedies in disease of these parts and functions. If it is elective for brain, spinal cord, lungs, stomach, bowels, kidneys, skin, serous membranes, mucous membranes, etc., we think of it as a possible remedy in diseases of these parts. In direct or specific medication, it is a first requisite that the drug influence the part or function which is diseased. In indirect medication it may influence any other part, and if good results it may be dependent upon counter-irritation, or the production of a second disease. Secondly, we want to know the kind of action. What is the result of the administration of a drug? is it excitant, depres- 368 SPECIFIC MEDICATION, sant? does it favor an increased circulation, innervation, func- tional activity, or lessen circulation, innervation or functional activity? In prescribing for disease the questions come-what drugs will influence the particular part? What drugs will influence it in the direction of health? Disease is wrong life, the ac tion of the drug is opposed to this, and looks to right life. The Homœopathic law of cure, similia similibus curanter, is based upon the fact that many drugs have two actions in kind, dependent upon the dose-the action of the small or medicinal dose being the opposite of the large or toxic dose. Drug prov- ing being done with toxic doses, the medicinal influence is the opposite of this, and if in disease we see the symptoms of the toxic action of a medicine, the small dose giving the op- posite effect will prove curative. Homœopaths may twist and turn as they please, they can not escape these conclusions. But as these opposite effects, dependent upon quantity, do not pertain to all drugs, and vary greatly with many, Homœopathy has a short leg, and must go halt many times. Still we do not wish to undervalue their investigations or their methods, for they will be found very suggestive and instructive. We propose to study the action of remedies on the living man-both healthy and diseased, as an important means of determining their action and use. Drugs influence the life, -must of necessity influence it to be remedies. They infiu- ence the life in health as well as in disease, though this influ- ence may not be so marked, owing to the greater power of resistance. In health the influence of a drug is of necessity disease producing, for every departure from the healthy stan dard is disease. Wanted to know-the elective affinity of drugs for parts and functions, we may give the drug to the healthy person. Wanted to know-the kind of action, we may use the drug in health. Wanted to know—the curative action of drugs, we are obliged to test them in disease, though they may have been pointed out by physiological proving. STUDY OF MATERIA MEDICA. 369 The method of "proving " is simple. The prover needs be in good health, and during the proving he should be careful that no outside or unusual circumstances are permitted to influence the action of the drug. If a topical action is wanted, we use it in such form that absorption will be slow. If an action from the blood is wanted, the drug must be so prepared that its absorption will be speedy and with little topical action. It is well in some cases to use it by hypodermic injection, or obtain its endermic absorption. The drug may be taken in the usual dose of old medicine, at first. The mind must be entirely free from prejudice, and no anticipation of the kind or situation of action indulged in. I have had some queer illustrations of the influence of the imagination in giving drug symptoms, one at least in my own person where the drug had been accidentally changed. Say, for instance, we take Podophyllum, finely powdered, grs. v. to x. in the morning on rising. We notice first, an un- pleasant sensation in the stomach, and our morning meal is troublesome, with a sense of fullness and weight. Following this is an unpleasent taste in the mouth, with gustatory sense impaired; saliva is increased in quantity, and is more tena- cious; mucous secretion more abundant; tissue of mucous membrane is fuller, especially marked in tongue; slimy yel- lowish fur on tongue; fauces tumid. Then comes uneasiness in hypogastric region, with sense of fullness and need of stool; fullness and weight in region of bladder, and disposition to pass urine. And during the day, a sense of weight in basilar brain; with some dizziness and loss of perfect command over the muscles. There will also be a change in the pulse, usu- ally accelerated; increased temperature, 99° to 100°, and some change in the skin. Finally if the medicine has sufficient in- fluence, a stool which is changed in character. This shows the localized influence of the drug, and the kind of influence in toxic dose, and will aid in pointing out the probable curative action. I take Podophyllum because it is a drug that most of our readers have taken, and have experi- 370 SPECIFIC MEDICATION. enced its effects in their own person, and not because it is a good example of the advantage of physiological proving. Attention has been called to the fact that dose is an im- portant element in therapeutics, and especially to the fact that many drugs exert a directly opposite influence in large and small doses. If this is ascertained with reference to any drug, then the therapeutic indications are plain. If we know the action of the large dose, and its influence upon parts and functions, we conclude that the influence of the small dose is directly opposite. Given, a disease showing the symptoms of structural and functional drug disease (large dose), we at once think of small doses of the same drug-because in small dose its influence is opposite. In other instance the action of the drug is the same in kind both in small and large dose, and knowing this kind of action, we oppose it to the disease showing opposite symptoms. There are quite a number of such drugs, and some of them are quite valuable remedies, there being no danger of mistakes from dose. Homœopaths employ the first class, but have little use for the second, as will be obvious to the reader. Again we find drugs producing some peculiar symptoms which do not form a part of, and are not recognized in the ordinary nosological clsssification of disease-symptoms which may be absent or present in many diseases, and still have no seeming reference to their origin, progress or duration. They are peculiar drug symptoms, and they are peculiarly Homoeopathic. No good comes from shutting our eyes to the truth, whatever may be its origin, or whoever its discoverer, and I would quite as soon credit Hahnemann with a discovery as Galen or Bennett. Again, we find that certain drugs will prove curative in disease presenting peculiar symptoms, which these drugs will not produce. These symptoms may be absent or present in any disease, without seemingly affecting the origin, progress, or duration, indeed seeming to have no relation to the pathologi- cal processes. Here the physiological proving gives no in- STUDY OF MATERIA MEDICA. 371 formation our knowledge comes from experimentation in disease, and the direction of experiment is an accidental sug- gestion. A few illustrations of these methods of study will prove interesting and profitable. They will be selected from the more common remedies, and so described that the reader may add them to his working Materia Medica, It is well to take Quinine as the first drug, as upon its “similia," so we are told, the whole structure of Homœopathy rests-Hahnemann discovered Homoeopathy in the fever of Cinchona. The physiological effects of Quinine are correctly given by Pereira, as I have proven on my own person, and in five other cases, and as the experience of seventeen years' continued use shows: 'Excitement of the vascular system, manifested by increased frequency and fullness of pulse and augmented respiration. Furred tongue, and other symptoms of a febrile state, are also observed. Disorder of the cerebro-spinal functions, indicated by head - ache, giddiness, contracted, in some cases dilated pupils, dis- order of the external senses, agitation, difficulty of performing voluntary acts, somnolency, in some cases delirium, in others stupor." All fevers, when measured by the thermometer, are periodic, the diurnal variation of temperature in the type called contin- ued ranges from 2° to 4°, and the febrile action from Quinia poisoning shows every shade from intermittent to continued, and is not usually the typical intermittent. But the reader will notice that we do not use Quinine as a remedy during vascular excitement, except there is a very evi- dent want of a stimulant to the sympathetic and other nerve centers. It is the direct stimulus we want, and it has refer- ence not to the apparent excitement, but to the real depres- sion. The remedy will produce a fever, and it will cure a fever. That it produces a fever, shows that its action is directly upon the functions involved in fever; that it cures a fever is 372 SPECIFIC MEDICATION. because it gives that stimulus necessary to the normal per formance of function, and we employ it when such stimulus is necessary. This property called antiperiodic, is something we know little about, except so far as we know the facts by experimen- tation in disease. Taking Ipecacuanha as the second example, we have a very good illustration of the first proposition, that the action of the small is the opposite of the large dose; and knowing the poi- sonous action we may predicate the curative. 66 If the powder or dust of Ipecacuanha be applied to the eyes or face, it acts as an irritant, and causes redness and swelling of these parts. Inhaled, it irritates the respiratory passages, and in some cases brings on difficulty of breathing, similar to an attack of spasmodic asthma" In but moderate doses continued for a long time, I can grow an irritation of every mucous tissue in the body, in some situ- ations going on to inflammation. In small doses it cures this very condition, and is the remedy for acute inflammation of mucous membrane. Irritation of mus- cular fibre underlying the mucous membrane is another symp- tom of its physiological action, and to this also it is a remedy. Not, however to the irritation of atony, as in the majority of cases of asthma, for here, in place of proving curative, it in- creases the disease. Tobacco is another very fair example of this action :-" Its most remarkable effects are languor, feebleness, relaxation of muscles, trembling of the limbs, great anxiety, and tendency to faint. Vision is frequently enfeebled, the ideas confused, the pulse small and weak, the respiration somewhat laborious, the surface cold and clammy, or bathed in a cold sweat." A distressing sensation of sinking at the pit of the stomach, is a characteristic symptom. Given these symptoms as a group, or the most characteristic of them, and Tobacco is a very certain remedy when given in small doses. The best preparation for medicinal use, is a tinc- STUDY OF MATERIA MEDICA. 373 ture from the fresh leaves, 3 viij. to proof spirit Oj.; macerate, express and filter-dose, gtts. x. to xx. to Water, giv.; a tea- spoonful every fifteen minutes to an hour. Of the dried To- bacco leaf, 3j. to dilute spirit Oj. is sufficiently strong. "( Hyoscyamus is another example, though not quite so marked. Faquier says, Henbane causes headache, giddiness, dimness of sight, dilatation of pupil, a greater or less tendency to sleep, and painful delirium. In some cases these symptoms are followed by thirst, nausea, griping, and either purging or con- stipation; and in a few instances febrile heat and irritation of the skin are induced." Given, a case of headache, with giddiness and dimness of sight, and Hyoscyamus will prove curative. Given, a fever, with the same symptoms, and Hyoscyamus will prove a valua- ble remedy. Taking examples of the second class, those whose action is the same in kind, whether the dose is large or small, we have a large number. And I will endeavor to select those in which the action is not topical, but from the blood. Jalap is a good example. Its action is that of an excitant to the gastro-intestinal canal in any dose. In large doses it is a painful and drastic purgative; in small doses continued it causes irritation. Nux Vomica is perhaps the best example. In the most mi- nute quantity it is a spinal stimulant, as it is in the largest dose, and the entire range of its use is as a stimulant to the spinal and sympathetic centers. Possibly, this assertion may be mod- ified by saying that in small doses the effect is not so much stimulation, as it is the prompting to normal functional ac- tivity. The characteristic symptoms produced in health by Nux Vomica are of the muscular system, showing its influence on the spinal cord: "A feeling of weight and weakness in the limbs, and increased sensibility to external impressions (of light, sound, touch, and variation of temperature), with de- pression of spirits and anxiety, are usually the precursory symp 374 SPECIFIC MEDICATION. toms. The limbs tremble, and a slight sense of rigidity or stiffness is experienced when an attempt is made to put the muscles into action." Then comes the convulsive action of the voluntary muscles, increasing as the remedy is continued. I have italicized the symptoms resulting from Nux, and which met with in disease are cured by Nux. But in moderate doses continued for some time, Nux Vom-. ica is an excellent example of the third action, producing cer- tain peculiar drug symptoms not readily accounted for, by the usual theory of its action. And, which symptoms being found in disease, the drug becomes a remedy. Thus, if the drug is continued for a length of time, it will in many cases cause an unpleasant colic with pain pointing at the umbilicus; pain in right hypochondria; and in women at the menstrul period a peculiar dysmenorrhoea. To these when observed as the result of disease, the Nux is curative. It will also give a peculiar sallowness of skin, with relaxation of connective tissue; a large tongue, with yellowish coating; and again, for these in disease it is a remedy. Thus whilst we see that the physiological action, as well as the influence in disease is that of a spinal and sympathetic stimulant, there is enough similia to give the drug value in Homœopathic prac- tice. If we examine Arnica, we find that it "quickens the pulse and respiration, and promotes diaphoresis and diuresis," and shows the properties of a stimulant to the ganglionic nervous system. It is for this purpose we use it in disease, and know. ing the action of the drug, we can use it when this stimulant influence is desirable. Furthermore, it appears to exert a specific influence over the nervous system, causing headache, giddiness, and dis- turbed sleep." These are the results of large doses, aud due to overstimulation. Here should come in the Homœopathic similia-when we have the peculiar sore or bruised head- ache with giddiness and disturbed sleep, give Arnica. It is an excellent indication, probably the best there is for the in STUDY OF MATERIA MEDICA. 375 ternal use of the remedy, but they don't say so. To show what they do say I quote Jahr's Repertory: ARNICA.-Stinging, creeping, or laming and bruised pains in the affect- ed parts; pains as if sprained, contused, hurt; red, shining, hot swellings, a number of small boils; the lower parts of the body feel cold, the upper hot; tensive pressure in the fore part of the head, as if the brain were squeezed up in a lump; itching, tearing or stitching in the head; immo- bility of the scalp; one cheek is hard and swollen; creeping in the face, nose, scalp, lips and gums; toothache as if the teeth were sprained and loose; white coated tongue; foul smell from the mouth; foul eructa- tions; vomiting of coagulate blood; spasmodic pressure in the stomach; splenetic stitches when walking; fetid flatulence; frequent small mucous stools; nocturnal enuresis; brown urine with brick-dust sediment; in- flammatory swelling of the scrotum and spermatic cord; hæmoptoe with discharge of bright-red blood or black lumps; stitches in the chest, especially when coughing or moving about; fetid breath; stitches in the region of the heart, with paroxysms of fainting." Returning to our first remarks on the subject, we find that remedies may be classified into- (a) Those which remove causes of disease. (b) Those which restore vital processes. Taking up the first class, we want to know the influence upon the life, of those drugs which remove causes of disease. We say that morbid accumulation in the stomach is a cause of disease, and it may be best to remove this with an emetic --to be determined by the action of different emetic agents up- on the processes of life, especially the effects subsequent to the act of emesis. Compare Tartar-emetic, Ipecac, Lobelia, Sanguinaria. Apocynum, Mustard, Common Salt, Sulphate of Zinc, as regards the act of emesis, and subsequent influence. In a given case of predominant wrong in the stomach by accumlations, we first determine whether this, or the drug ac- tion will do the greatest wrong to life; and concluding that it is best to effect its removal, we select that remedy which will accomplish the object with the least expenditure of vital pow- er, leaving the organism in the best condition, or doing any- thing that needs be done to restore normal functional activity. This is an important study, and the method of comparison must lead to a better use of remedies, and training the mind 376 SPECIFIC MEDICATION. to accurate thought it will serve a very important use both in diagnosis and therapeutics. As we study the gross action of the group emetics, we study the class, cathartics, diaphoretics, diuretics. Here is a series of agents producing alvine dejections-to determine their use, and the individual agent to be employed. Query first-will the removal of the intesinal accumulations be a greater relief to the life than the drug depression: is the patient better with or without the medicine. Then the comparative action of Podophyllin, Jalap, Scammony, Colocynth, Castor Oil, Senna, Magnesia, Cream of Tartar, Crab Orchard Salts, etc. As has been remarked before, it is a good thing to get our remedies well in hand, and know them individually. We not only want to know the gross action, but the more delicate shades of action; not only the action in health, but also in the varied changes of disease. Does a remedy influence the life? At once comes the ques- tion-how? First, as regards the difference in dose-to be determined-its influence in large, medium, small and minute doses, infinitesimal if you choose. Second, as to location of action—is it general, localized, definite? Third, as to kind of action—does it increase, diminish, or alter? Fourth, is its action physiological-the same in kind and quantity in all cases; or queer, depending upon certain symptoms, which seem to have little relation to the condition of disease. If a remedy is not well known, and we wish to give it an investigation, we commence experimentation with it. Possibly with a physiological proving, for which a dog is handy, a man better. You take it yourself, you persuade other persons in the household to take it. You determine to give it to the sick-select a case in which the known action of the drug in small dose is likely to restore some impaired function, or do something that needs be done. The remedy is used singly- note the results. You need not be afraid of the patients dying, they won't die from deprivation of drugs, you may be sure of STUDY OF MATERIA MEDICA. 377 that, and with the small dose of one medicine you will hardly poison them. Many times the discovery of important therapeutic properties is purely accidental. You prescribe a drug for one thing, and it does something you did not expect. Now you want to be wide awake, not only to know what is done, and what has done it, but the peculiar condition of this patient. And so certainly as you find the same peculiarity in another case recollect the same remedy. We prescribe a remedy for some of its usual effects on func- tion, and find to our surprise that the entire disease rapidly fades out before it, and the single agent cures. We ask our- selves at once, what is there peculiar and distinctive in this case? and we carefully scan all the symptoms until we find it. Finding some special symptom, we associate it with the remedy, and when observed in another case we try the rem- edy again. We read in a journal or text book, a description of some disease, and see that the writer has had more than ordinary success with a remedy; we want to know what is peculiar in these cases. We examine the text carefully—the writer may mention it incidentally; if so, we associate the peculiarity observed with the curative drug, and test it when we meet similar symptoms. I have thus briefly called attention to the methods employed in the study of the Matera Medica, and hope these articles may stimulate many to give the subject thought. Very evi- dently it is a broad field for investigation, and must repay the diligent student. It "pays" to study; possibly, not directly in money, but certainly in development of mind, and increase of happiness. A single therapeutic discovery is a blessing to humanity, and the man who makes it has lived to a good purpose. 32 378 SPECIFIC MEDICATION. Obstetric Remedies and their Use. t This may not be a very good classification of remedies, but I think we can make it a useful one. It is well to be able to think of remedies in groups, and for special uses, and if we can make a group for obstetrical practice, it will be one step toward a proper selection. We want a competent materia medica; the fewer the remedies the better, so they answer our purposes. We want each to have a well-defined, direct influence, so closely associated with expressions of disease, that the idea of the remedy is at once suggested by disease expression. If I were to designate a common obstetric materia medica, or remedies for an obstetric medicine case, it would be-Nux Vomica, Aconite, Macrotys, Pulsatilla, Lobelia, Gelseminum, Chloroform, Ergot, Tincture of Oil of Cinnamon, Chlorate of Potash and Phytolacca, with possibly Fluid Extract of Jalap and Senna. Here is brevity, and here is certainty as well; and whilst we can count the agents upon our fingers, a know- ledge of their use will give more than ordinary success. If we commence with the functional wrongs of the repro- ductive apparatus that prevent conception, we will find in the first four the means that will bring about the desired result. Dysmenorrhoea will be relieved by Pulsatilla and Macrotys, aa. 3ss., Water 3iv.; a teaspoonful four times a day, com- mencing three or four days before the expected period. The same prescription relieves the common menstrual suppression, tardy menstruation, insufficient menstruation, or irregular menstruation. The sub-inflammatory condition of the ova- ries and uterus, that follows marriage, or is brought on by sexual excess, is usually relieved promptly by-R Tincture Aconite, gtt. v.; Tinct. Macrotys. gtt. x.; Water 3iv.; a tea- spoonful every one, two or three hours. The unpleasant feel- ing of fullness and weight in the pelvis, with hypogastric pain, that is associated with menstrual irregularity, is cured by— R Tinct. Nux, gtt. v.; Tinct. Macrotys, gtt. xv.; Water, Ziv.; a teaspoonful every two hours. Gelseminum may take the OBSTETRIC REMEDIES. 379 place of the Aconite, Pulsatilla and Nux, with the Macrotys, if there is great nervous irritability, with an excited condition of the circulation. Thus we have remedies that rectify the usual functional wrongs that prevent conception, and having thus made a good commencement, we are ready to look after the ills of preg- nancy. The first and most prominent of them is "morning sickness," which sometimes goes on to persistent nausea and vomiting, endangering the health, if not the life of the pa- tient. For this Nux Vomica will be found a very certain remedy. Ę Tinct Nux, gtt. j. to gtt. v.; Water, 3iv.; a tea- spoonful as often as necessary. If it fails we think of Lobelia or Gelseminum. Lobelia if the tissues are full and doughy, Gelseminum if they are contracted. The dose will be small. R Tinct. Lobelia gtt. j. to gtt. iij.; Water 3iv.; dose, a tea- spoonful. R Tinct, Gelseminum, gtt. x. to gtt. xxx.; Water, Ziv.; a teaspoonful as often as necessary. For the unpleasantnesses that arise during gestation, we find remedies in the same group. For rheumatism of the uterus, or pain simulating it,— R Tinct. Aconite, gtt. v.; Tinct. Macrotys, gtt. xv.; Water, 3iv.; a teaspoonful every one, two, or three hours will prove effective. For pain in back and hips, extending down the thighs, we frequently pre- scribe- Tincture Pulsatilla, Tinct. Macrotys, aa. gtt, xv.; Water 3iv.; a teaspoonful every three hours. If these pains are associated with a sense of muscular debility, we substitute Nux, as- -R Tincture Nux, gtt. v.; Tinct. Macrotys, gtt. x.; Water, 3iv.; a teaspoonful every two or three hours. For the unpleasant sensation of weight and dragging in the abdomen and pelvis, we use Lobelia, as we do for oppression of the respiratory apparatus, and especially præcordial op- pression. The dose will vary, but will always be stimulant, not nauseant. For the unpleasant nervous sensations, dread, etc., Pulsa- tilla is an excellent remedy, and will usually give prompt re- lief, unless they are symptomatic of some distinct wrong. For the urinary irritation, and difficult micturition some- 880 SPECIFIC MEDICATION. times seen in gestation, Gelseminum will prove a remedy, given in the usual doses. False pains will be relieved by Aconite and Macrotys, or Pulsatilla and Macrotys, selecting the one or the other as heretofore named. For rigid os or perineum, we have Lobelia and Gelseminum. Lobelia if the parts feel full, Gelseminum if they are thin and rigid. Lobelia is the remedy commonly indicated, and whether the parts are full and hard or full and doughy, its influence is direct and very certain. And there is this beauty in its action -that whilst it puts the structures in better condition, both as to dilatation and increase of mucous secretion, it favorably influences uterine coutraction, so that whilst more efficient, it is less painful. If there is any one remedy in obstetric medi- cine more useful than another, it is Lobelia (a tincture of the seed). Gelseminum is employed when the tissues are thin and tense, with want of secretion, uterine contractions being painful; and in this case it will be found to give excellent results. Unequal or irregular uterine contractions-giving tedious labors are relieved by Macrotys; Aconite and Macrotys, if there is an excited circulation; Pulsatilla and Macrotys, if the patient is nervous and has unpleasant sensations of dizzi- ness, or feels that "there is something wrong with the child; Lobelia and Macrotys, if there is fullness' and oppression of pulse; Nux and Macrotys, if there is constant complaint of the back, “as if it would break." It is hardly necessary to say that relief from unequal or irregular contractions by these means, implies "better pains," and a speedier delivery. Want of pain, or tardy pains, are met by Lobelia in some cases, and by Macrotys in others, the selection being made as heretofore named. The use of Ergot is restricted to the second stage of labor, and to cases of deficient contraction, want of pain, or ineffi- cient pains. It is better used in infusion, from the fresh drug, Zij. to boiling water, 3iv.; a tablespoonful every ten or fifteen minutes. OBSTETRIC REMEDIES. 881 For post partum hemorrhage the common remedy is Tinc- ture of Oil of Cinnamon, in doses of one-half to one tea- spoonful. It is very certain in its action, and rarely fails to do all that a medicine will do. Ergot may be used when there is marked want of uterine contraction, though the cases are very rare. It will not do, however, to substitute medicine for the necessary attention-the removal of the placenta, the hand upon the uterine globe until firm contraction, and quiet in the recumbent position. After-pains are best met with minute doses of Macrotys, in combination with either Aconite or Pulsatilla, as may be in- dicated. Of course this does not arrest them, as would an opiate, but simply makes them more bearable; but the mother will get up much better than when the opiate is employed. Aconite is the remedy for milk fever; though a motion of the bowels may be solicited by any of the common means, or by the fluid extract of Jalap and Senna, named in our list. For caked breast, pains in the breast, mammary inflamma- tion, chapped nipples, etc., Phytolacca is the remedy, inter- nally and externally. Internally-R Tinct. Phytolacca (green root), gtt. x.; Water, 3iv.; a teaspoonful every two hours. Externally-R Tinct. Phytolacca, 3ss.; Water, 3iv.; applied as a wet dressing. • For scanty or suppressed lochia, we have Aconite, Macrotys, Pulsatilla, selected according to the indications heretofore given. They may be supplemented or replaced by an infusion of Pennyroyal. For sepsis, fetid lochia, unpleasant breath, or any of the wrongs that come from the absorption of animal matter, either from the discharges or in the involution of the uterus, Chlo- rate of Potash is the common remedy. Under its continued use we find that a retained placenta may decompose and pass off with the discharges without serious danger; and it will usually remove all the unpleasant symptoms that are associ- ated with sepsis. Of course Chlorate of Potash does not take the place of proper manual attention on the part of the ac- coucheur. 382 SPECIFIC MEDICATION. This is a very brief synopsis of an Obstetric Materia Med- ica, yet will be sufficient to point out the remedies that need be studied, and the common use of those named. Post-Partum Remedies. We have had in review the principal remedies employed for the ills of pregnancy and parturition, and may complete the subject by a brief consideration of the ills and remedies of mother and child for the month following delivery. It is a good thing to still bear in mind that we are dealing with a physiological condition, and not one of disease. Our patient requires rest, that the tissues engaged in child-birth may recover their normal condition. In the majority medi- cine is not required, but instead the mother requires good, nutritious food, cleanliness, good air and rest. Starvation— or toast and tea-does not answer very well, and we will avoid many mishaps by getting rid of the old ideas of light diet and purgation For after-pains it has been the rule to prescribe an opiate. Some would be content with the milder diaphoretic or Dover's powder, but others would give morphia in pretty full doses. As a rule, the stronger the dose, or the more frequent the rep- etition, the worse the patient is off. I am satisfied that many of the chronic ailments of women may be traced to this as a cause. I should say to the young physician, never give Opium in any form in this case. I have the same objection to Chlo- ral, which, though it acts very kindly in some, is a cause of blood-poisoning in others, giving a slow and bad getting up. But as we thus exclude the agents that act directly in ob- tunding the nervous system, you may say that we can not give relief, and must lose our practice. Not so fast. It is very certain that the involution of the uterus in multipara requires a certain amount of pain-synonymous for uterine contrac- tion. A reasonable amount of after-pain is a good thing, and mothers and nurses are not slow in learning the lesson. But we do not want too much, and to modify it we have Macrotys, + POST-PARTUM REMEDIES. 883 Pulsatilla, Viburnum, Nux, and the sedatives. If the circu- lation is somewhat excited I would prescribe-R Tinct. Aco- nite, gts. v; Tinct. Macrotys, gtt. xx.; Water, 3iv.; a tea- spoonful every two hours. If she was nervous and despond- ent, I should give-R Tinct. Pulsatilla, gtt. x.; Tinct. Macro- tys, gtt. x.; Water, 3iv.; a teaspoonful every two hours. If with the pains there was nausea, flatulence, pain about the umbilicus, I should give-& Tinct. Nux, gtt. ij. to gtt. v.; Tinct. Macrotys, gtt. x.; Water, 3iv.; a teaspoonful every hour. It is very rarely that these means will fail in giving the neces- sary relief. An offensive lochial discharge means mischief, local or gen- eral, and calls for cleanliness-and Chlorate of Potash. There is no mistake that this is the antiseptic of the puerperal state in a very large majority of cases, and if it was promptly used when the offensive odor first shows itself, it would save a great deal of trouble. In some cases there is retention of blood-clots, which undergo decomposition, and in miscarriages occasionally a case in which the placenta can not be removed without too much force. Even in the last case I should feel entirely safe to leave the case to nature and to-Chlorate of Potash. A too free lochial discharge is usually controlled with small doses of Ipecac, one-tenth to one-fourth grain every two or three hours. I like the smaller dose, and would prefer it in a trituration. If the lochial discharge is scanty or arrested, I prescribe the sedative indicated, Veratrum or Aconite, with Macrotys, or a tea of Pennyroyal. Sometimes the two may be associated together. The milk-fever is readily controlled with the proper seda- tive, Aconite being the usual remedy. Nursing sore-mouth may make its appearance early, and is one of the most serious ills of nursing, and one for which old medicine gave us no remedy Possibly we have yet no reason to boast, as we have nothing absolute; still I think the reader will find in Phytolacca and Collinsonia, remedies for a large 884 SPECIFIC MEDICATION. number of cases. I prescribe Phytolacca when the tongue and mucous membranes show pallor; Collinsonia when the color is vivid and bright. Of the first-R Tinct. Phytolacca (green root), 3ss.; Water, 3iv.; a teaspoonful every three hours, and as a wash. Of the second-R Tinct. Collinsonia, 3j.; Simple Syrup, 3iij.; a teaspoonful every four hours. Tobacco smoke is an excellent palliative. Infantile sore-mouth, as usually met with, is very readily cured with Phytolacca. Even the severe aphthæ yields to this more readily than to any other remedy. It is given in small doses―gtt. v. to water, 3ij.; four to ten drops at a dose. Mammary irritation or inflammation, in the early stages, yields readily to Phytolacca in most cases. I have prescribed it for a dozen years, and with most satisfactory results. It is given internally in small doses, and applied diluted to the breast. Do not forget that proper support to the sensitive breast is of great importance. Phytolacca is also a valuable remedy for sore nipples, espe- cially when the structure is swollen and sensitive; sometimes it will effect a permanent cure. Of course it is not a remedy for simple erosion and ulceration, unless the gland is also dis- eased. In these cases we use it internally, and apply it diluted to the nipple. Of all the means employed for the relief of ulcerated nip- ples, nothing has served my purpose so well as the lead nipple shield. It is hammered in the form of the nipple, so that it is light and fits accurately, or it is moulded out of thin sheet lead. The nipple is carefully dried after the child nurses, and the lead shield is worn constantly. Infantile colic is treated with Nux or Lobelia and a stimu- lant. If the child simply shows abdominal pain, and draws its feet upwards, I prescribe-& Tinct. Nux, gtt. j.; Water, Ziv.; a few drops frequently repeated until relieved. If the face looks full, and the respiration oppressed, it would be- R Tinct. Lobelia (sem.), 3j.; Tinct. Lavender Comp., 3ij.; Simple Syrup to 3ij; five drops every fifteen to thirty minutes until relieved. If the features are pinched, and there are fre- REMEDIES IN DISEASES OF WOMEN. 385 quent discharges from the bowels with straining, give an infu- sion of Epilobium. It would not do to omit saying, that for a mother's prescription, there is nothing safer than Catnip tea. In some cases the lochial discharge, becoming colorless, persists for a long time, and the mother gets up from her bed feeble in body, and especially feeble in the reproductive organs. She is markedly pallid, has a feeble pulse, and a poor appe- tite. In this case I prescribe Graphites, first dilution, gtt. x. to water 3iv.; a teaspoonful every three hours. This is but a small portion of what might be said with refer- ence to these cases, but our object has been to bring forward the remedies adapted to the more common ailments. Remedies in Diseases of Women. In the list of remedies favoring the menstrual discharge may be included Iron, not only as a blood-maker, or a general remedy, but for its local influence. Blueness of parts, usu- ally with pallor, may be taken as the best indication for its specific action. Tissues are full, and frequently the lower segment of the uterus will give a doughy or sodden sensation to the finger. The Tincture of Muriate of Iron-a specific in a certain variety of erysipelas-will be indicated by erysipeloid redness of the surface, frequently of the lower extremities, and of the external and even of the internal parts. One of the most marked indications for iron is constant pain in the posterior part of the head. Apocynum is a very valuable remedy in the treatment of diseases of women. The indications are: fullness of abdo- men, uterus enlarged, and tendency to oedema of the extrem- ities. Graphites may be employed when the monthly discharge is pale and watery, with prominent hysteric symptoms. Polygonum, when there is a sensation of weight and full- ness in the pelvis, with aching in the hips. 33 386 SPECIFIC MEDICATION. The Mitchella, Senecio and Helonias find a use here, but I im not able to point out the special indications for either, Tincture of Phosphorus may be thought of as a remedy when there is want of innervation, and the reproductive func- tion (venereal desire) is markedly impaired. Iodine has a similar use, and is usually associated with Nux (compound iodine pill), to give energy to the reproductive organs. When we think of the remedies for the conditions of too free, too frequent in recurrence, and prolonged, we wish to make a classification into those for plus vascular and nervous excitement—active condition; and minus vascular and ner- vous excitement-passive condition. The remedies for the first will be found in the class seda- tive-Aconite, Veratrum, Lobelia, Bryonia, Rhus, Lycopus, Gelseminum, Asclepias, and we need not give them an indi- vidual study here. The second group may be headed with Carbo-veg., which is one of our most certain remedies. The indications are-pal- lor, looseness of tissues, and a soft, open pulse. It not only regulates the menstrual discharge as to quantity, frequency of recurrence, and duration, but it exerts a marked influence upon the nutrition of these tissues. I use a trituration one to ten, and possibly it would be better in some cases to use a second trituration. The Hamamelis is another very valuable remedy, and is indicated by fullness of pelvic tissues, laxity of perineum, and impairment of the venous circulation. These are the in- dications for the remedy, whether there is a wrong of the menstrual function or not. Ergot may be employed when the tissues are full and re- laxed, and when there is oppression of the nervous system, the patient being dull, stupid and careless, Ipecac is a very valuable remedy when there is local irrita- bility with lax tissues, though it may be employed in any case in which irritability of the mucous membranes is a marked feature. REMEDIES IN DISEASES OF WOMEN. 887 The pain or uneasiness associated with the menstrual dis charge, and felt at other times, is very variable in character and intensity. There may be nothing characteristic about it or it may point out the remedy for us Nux is the remedy we usually think of for uterine colic. Do not mistake the language-there is a uterine pain that simulutes colic, even to its wandering character in the lower abdomen and pelvis. The remedy not only relieves the pain, but greatly aids in establishing normal nutrition and func- tional activity I saw a marked case in the early part of the year 1874, in which the woman had been a constant sufferer from uterine disease since 1867. The character of the pain was so decided that I gave her nothing but Nux at first, and as the results were so satisfactory, no other remedy was em- ployed, and she made a good recovery in three months. We do not want to forget that the Macrotys, Caulophyllum, Actæa and Pulsatilla, are remedies for pain, and may be in- dicated by pain. As remarked at first, nearly all of these remedies look toward a normal function, whatever may be the indication for their use. The Viburnum (Opulus) high cranberry, cramp bark, is a most valuable uteriue remedy, and not only looks to normal innervation, but to normal circulation and nutrition as well. It is indicated by pain-its common name, cramp bark, is very suggestive of the kind of pain-uterine spasm. The Viburnum (Prunifolium), black haw, exerts a very similar action, and is also indicated by pain-expulsive and intermittent. Both are remedies for abortion, and especially to remove the predisposition to it. The reader will recall cases in which there is a continued tendency to abortion, and will probably recollect that the ordinary treatment of uterine disease in such cases is very unsatisfactory. I think the ex- perienced physician will be able to think of a condition of the reproductive organs, which, without any history of the case, would impress his mind as one favoring abortion. These are the cases for the two species of Viburnum. 888 SPECIFIC MEDICATION. Rhus is indicated by the usual symptoms, burning pain and heat, structures pinched. Indications, Apis is a very fine remedy in some cases. burning with itching, especially of the bladder and urethra. Collinsonia is sometimes a remedy, the indication being a sense of heat, rawness and contraction, usually about the anus or in the rectum (associated with hemorrhoids), or sometimes at the entrance of the vagina. Cannabis Indica is a remedy for erythism of the reproduc- tive organs, and venereal excitement. Staphysagria is a remedy where there is fullness of tissue, abundant mucoid discharge, and dull brooding of the mind with involuntary outbursts of passion. This is a very brief sketch of some of the remedies em- ployed for their direct action upon the uterus. I have pointed out some of the more prominent indications for their use, especially with reference to impairment of the function of the reproductive apparatus. One can not, in a brief article, give full descriptions; it is at best suggestive for further study. In this case, as in some others, I would advise a study of our materia medica with reference to the action of remedies upon the reproductive organs and function. Treatment of Pain. The evidences of health are-the ability to do the work re- quired of the whole or a part, and the ability to do it with pleasure. Every function of the body should be pleasurable in health. The use of the eye, the ear, the nose, the mastica- tion of food, the act of digestion, defecation and urination, the use of the muscular system, and the action of the mind. As pleasure in living is one of the best evidences of health, so is discomfort or pain one of the most common evidences of disease. Indeed, I think we may say that disease is an- nounced by feelings of discomfort, and these attend it in every stage of its progress. It is not always severe pain, perhaps in TREATMENT OF PAIN. 389 the majority of cases it can not be called pain, but it is un- pleasant. Let us say, then, that pain and unpleasantness are common symptoms of disease-symptoms of every disease. It is so common that we come to regard it as a part of disease, but it will not do to regard it as the disease itself—it is nothing but a symptom. When our attention is called to pain, what should we think of? Some would answer Opium or Morphine, but I would suggest that it would be better to think of the disease of which pain is the expression. If there was no disease of the part suffering, or of the brain which receives the impression, there would be no pain; take away the disease, and the pain is gone, Can you say as much of narcotics-take away the pain, or obtund the brain so that it can not feel pain, and the disease is gone? I think you would hardly dare to take that position. But you say that patients can hardly wait for the removal of the disease, they want immediate relief. Let us see about this. One is suffering from facial neuralgia, and you give one- fourth grain of Sulphate of Morphia; it gives partial relief in an hour, and possibly the patient has an uneasy sleep for a couple of hours. When she awakes she awakes with pain, to which is added an uncomfortable sensation in the head and stomach; you repeat the dose, but there is only temporary relief, and a still greater feeling of general discomfort after- wards. How long, on the average, will it take you to get en- tirely rid of the disease and the pain? Suppose the case a pleuro-pneumonia, would you give Mor- phia, even though the patient was suffering severely? If you did, you would very likely do the patient a very great wrong, and you would find that the narcotic at best only gives tem- porary relief, and that the prolonged unpleasantness of disease more than compensated for the temporary ease. In such a case the proper sedative, Aconite or Veratrum, with Ascle- pias, Bryonia, or Rhus, as indicated, will give permanent re lief sooner than any narcotic. Suppose, for instance, you have severe pain in any part, but 890 SPECIFIC MEDICATION. it is decidedly periodic, and the patient has been in a mala- rial region, what would you give? A narcotic? It strikes me that none of my readers would do so foolish a think as this. You say periodicity, remedy quinine, and at once pro- ceed to give it in the usual anti-periodic doses; if it is a Qui- nine case, the relief is prompt and permanent. If now 1 should tell you that this patient, who is suffering severe pain, has a flushed face, bright eyes, contracted pupils, and increased heat of the scalp, what would you give? You say Gelsemi- num, I say Gelseminum, and we all say the man who would give Morphia in such a case is a fool, and should be gathered in by the fool-killer. Why are we so positive in this case? Because we have learned to recognize this condition of disease as associated with the curative action of Gelseminum. Let us have another common example. Here is a patient suffering severe pain (I care not where), his face is full, his eyelids full and heavy, the veins of his neck and face are full, the veins of his hands are full, his tongue is full, put your hand on the abdomen and you get the sensation of fullness— what does he want? I say Podophyllin, you say Podophyllin, and we all say that the man who would give Morphia in such a case should become a granger, or "go west and grow up with the country." Why do we say so? Because we know the ex- pression of disease and its relation to Podophyllin as a remedy, Again another. Here is a pregnant woman who has been suffering a multitude of aches and pains in the pelvic region. and as they have become almost unbearable, she applies for relief. Evidently they have their starting point in the uterine globe, and are dependent upon a wrong in its evolution. We would never give a narcotic in such a case, it would be crimi- nal mal-practice. But we associate the pain with the known action of Macrotys, and giving this, we give speedy relief. Let us take the severe burning pain of erysipelas, as an ex- ample with which all are familiar. I have seen physicians who had no more sense than to give Morphia to relieve this pain, and "give the patient rest "—and it would be frequently TREATMENT OF PAIN. 891 that rest that knows no awakening. Have you seen such a case relieved in a few hours with tincture of Muriate of Iron? If so, you have seen a fair illustration of the teachings of this work-that the remedy for the disease is the best remedy for the pain. In the past two years we have had a series of cases in which pain was a prominent symptom, no matter where the disease was located. As a part of this pain, frequently, was severe orbital pain on the left side; this, together with the sharp stroke of the pulse, and the peculiar redness of the papillæ of the tip of the tongue, was the indication for Rhus. I have seen the remedy relieve the severest pain in an hour, and arrest it permanently in twelve to twenty-four hours, in cases where Morphia had wholly failed to give even temporary relief, be- cause the narcotic dose would not be tolerated. The majority of my readers have had a like experience. Let us take the case of rheumatism. Would you not regard the exhibition of opiates for the relief of this pain as an ab- surdity-worse, as mal-practice? Every practitioner who has observed closely and thought of his cases, will have noticed how speedily pain is relieved, in many cases, by the proper anti-rheumatic. Here is a series of cases that are promptly cured by Macrotys-not only does the patient get temporary, but permanent relief. Here are others, in a different locality or year, relieved by Bryonia, Sticta, or Colchicum, and an- other series that yields to acids or alkalies. It seems a little singular to see pain at once alleviated by the free use of lemon juice, and the disease speedily cured, and in cases in which the narcotics would only give partial and temporary relief. This is a good subject to think of, and it is one that deserves careful thought. If I have pointed out a series of cases of severe pain, in which the proper remedies for the disease are also the very best remedies for the pain, have you any right to say that the right treatment for the disease would not be the best remedy for pain in every case? It is true we do not know the "right" treatment of disease in all cases, but we 392 SPECIFIC MEDICATION. can learn it if we try, and we can get along very comfortably without the use of narcotics, in the larger number, until we do learn. Classification of Remedies. If every physician could be convinced that it was necessary for him to make a study of the action of remedies in the cure of disease for himself, and not place his entire reliance upon the teaching of the books, practical medicine would advance rapidly. The dependence upon authority dwarfs the mind, obscures the senses, and forms an almost impassable barrier to individual observation. "If these men, learned, in high social position, and with all the appliances of science, have not been able to go further, what can you expect to do who have none of these?" This question, asked by one who claims to be a leader in Eclecticism, I propose to answer, and show that the poorest, most ignorant, and feeblest of physicians may do a great work for himself, and something for the gen- eral advancement of medicine. Every man has some spare time which he should utilize in study, and I propose that a portion of this be devoted to the study of remedies. Take your Dispensatory or Materia Med- ica, and make a list of the drugs you know something about, preparatory to a classification. In this classification you may take any statement of the books that your experience has confirmed, but do not take any thing upon the authority of the writer alone. Having the group of agents before us, we propose to classify them ourselves, and to put it in writing, that we may have it before us for revision as our experience grows larger. We will make the simplest groupings of med- icines first. Let us say, remedies may be first divided into two great classes-those which have a general, and those which have a local action. Of course many medicines will have both a general and local action, but one will be decidedly first and CLASSIFICATION OF REMEDIES. 393 prominent, so that with the majority the classification is readily made, as for example: GENERAL REMEDIES. LOCAL REMEDIES. Aconite, Veratrum, Quinine, Baptisia, Khus, Macrotys, Lobelia, The Sulphites, Alkalies, Acids. Gelse minum, Nux, Podophyllin, Leptandrin, Chionanthus, Uvedalia, Hamamelis, Eryngium, Viburnum, Ipecac. You notice that it requires a little thought to make this classification, and you read your authors with more care, and recall your experience with remedies more fully, in order to do it satisfactorily. Of course this work requires time, but it gives an education of the mind that could hardly be obtained otherwise. If now we say of the action of remedies, both general and local, that they must either increase, diminish, or change from the normal standard, we will be enabled to make a second grouping in these classes. We might call these excitants, sedatives, and, using the old term with a new meaning, alter- atives. Taking the action of remedies in small doses, we might make a grouping as follows : SEDATIVES. EXCITANTS. Veratrum. Quinine, Aconite, Nux, Gelseminum, Belladonna, Rhus, Lobelia, Cactus, Podophyllum. Iris, Pulsatilla, Sanguinaria, Macrotys, Phosphorus, Asclepias, Arsenicum, Ipecac, Apis, ALTERANTS. Baptisia. The Sulphites, Leptandra. Phytolacca, Drosera. Stillingia, Collinsonia, Viburnum, Eryngium, Apocynum, Graphites, Lycopus, Iron, Acids, Bryonia, Cuprum, Alkalies, 394 SPECIFIC MEDICATION. • As you read the lists over you are not so certain it is well done; you would shift the agents from one class to another, or at least you would "have to think about it." That is the very object we bave in view, and in “thinking about it,” you will learn more of materia medica than you could possibly learn in any other way. If now we take our group of general remedies, we find that we can make sub-classes, according to the action of the med- icines upon different functions or parts which are general. Thus we have a nervous system which controls the body, divided into brain, spinal cord, and sympethetic, and the remedy may expend its principal force upon either the one or the other. We have a blood which is the common source of supply, and the common sewer of the whole body. The rem- edy may influence the structure of the blood in any of its sev- eral parts, or may influence the sewage afloat in it. Then we have the circulation of the blood, and we may have wrongs of this, which are in frequency, impairment, or irregular distri- bution. We have a lymphatic system common to the entire body, which may be a source of disease. The apparatus for the removal of waste, is also to be taken into the estimate, for we have here sources of general disease. And finally we have to take into consideration the condition and forces of life— heat, electricity, and formative force. The reader will notice that classification grows more diffi- cult as we progress, and calls for closer study, and more thought. But it has this in its favor, that it brings out all we know of medicine, and enables us to classify our own knowledge and that of the books, so as to make them useful. When we study local remedies we find that they may be classified in a similar manner, some of them readily, others with difficulty. We have remedies that influence the respi- ratory organs, the digestive apparatus, the urinary apparatus, the excretory apparatus-skin, kidneys, bowels-the brain, etc. We find also that some remedies may be classified as they influence special tissues-mucous membranes, serous membranes, connective tissue, bones, etc. We find that rem- CLASSIFICATION OF REMEDIES. 395 edies not only have an elective affinity for parts, but their in- fluence is uniform in health, and in similar conditions of disease. Let us call this the first study of remedies, a study that recalls and fixes that which we know, and that gathers from books the essential facts, or what seems to us essential facts of drug action. It is work, but I will guarantee that the phy- sician comes out of it stronger in mind, and very much better able to prescribe for disease. There are some things which can only be learned by exper- iment, and I would urge every one to some effort in this direc- tion. You have your own bodies, and though you may value them highly, it will do little harm to test some medicines up- on your own person. One can also, occasionally, persuade a friend to take a part in testing a remedy. There is nothing in medicine that I would not test on my own person, if I was en- gaged in studying its action. Very certainly if the physician has occasion to take medicine for any disease, he should care- fully note its effects from hour to hour. Let us call this the second method of studying remedies. It is the Homœopathic method, though employed to some extent by all classes of physicians. It gives most excellent and reliable results, and we can not afford to dispense with it. The third method is by carefully studying the effects of remedies administered for disease. This study can only be made to advantage where notes are kept, when care is used in the diagnosis, and when single remedies, or remedies that act in the same way, are employed, It is true that we can carry something in our memories, and by repeated observations facts will become familiar, but it is not a good plan to trust the memory too far. There are two things we want to know-the expression of disease, and the action of remedies-and in so far as we can, we want to associate them together. We may keep a record of cases with but little writing, if we have a plan to commence with. One word will sometimes express the condition of dis- ease, it will rarely require more than a line. We write of one 396 SPECIFIC MEDICATION. fever; to another we prefix the word intermittent, remittent, continued, typhoid; or it may be variola, rubeola, scarlatina; or catarrh, laryngitis, pneumonitis, enteritis, phrenitis, etc. We have a whole history of the common progress of a disease in a word or two. Now when giving remedies we may note nearly as briefly the reason why we have selected the remedy, Pulse small, frequent-Aconite; pulse frequent, sharp-Rhus; veins full-Podophyllum; tissues full, oedematous-Apocy- num; muscular pain-Macrotys; nervous, free from fever- Pulsatilla; periodicity-Quinine; dull, stupid, sleepy-Bel- ladonna; pain of serous membranes-Bryonia; dusky color- ation of surface or mucous membranes-Baptisia; mucous membranes deep red-Acids; mucous membranes pale-Al- kalies; feeble heart-beef-tea; strong circulation, high tem- perature-boiled milk. I give examples as my memory recalls them, but I think that the majority can have a record in about as many words. We do not want to write a book for other persons, but to make such notes as will enable us to recall the entire history of the disease, with its expressions that have suggested the use of the remedies employed. The reader will see that the record of the effect of the medicine can be easily kept. A 0 will tell the story of no effect, and a group of half a dozen adjectives will note the more important influences that we wish to record. My Pocket Case. In making a study of our working materia medica, it is wel to note the advantages of carrying remedies, and of extempo raneous prescription at the bedside. The advantages are threefold-to the physician, to the patient, and to the friends. To the physician in that he learns his remedies better, and prescribes with greater certainty. To the patient, that the remedies are given in less doses, are promptly administered, and are not admixed with unpleasant vehicles, and are of more certain value and action. And to the friends, that much MY POCKET CASE. 897 trouble is saved in providing the medicines, as well as much unnecessary expense. I have no special love for retail druggists, and many un- pleasant experiences have shown me that it is quite possible to procure the poorest drugs in the market from them, and that it is quite uncertain what you will get in any given case. Of course there are many exceptions, but this is applicable to the druggist in ordinary, who makes it a rule to buy cheap, and sell dear. I need not say that a contract between physi- cian and druggist, by which the former receives a percentage on prescriptions, is a very small species of swindling, and un- worthy the profession. Patients will soon recognize the advantage that comes from a well filled medicine case, and will pay their bills more promptly if they are not bled by the druggist. Talking about bleeding, I have seen, time and again, a poor family saddled with an expense of from thirty cents to a dollar and a half a day for weeks, and for drugs that were useless, or in quantities much larger than were necessary. Recently I counted on the mantel of a patient, seven four-ounce, two six-ounce, and three two-ounce bottles, with three boxes of powders, all of which had been procured in seven days for a child four months old. This physician probably had a percentage. As regards the form in which medicines are dispensed, I greatly prefer fluids, as they are easily measured, miscible with water, which is the best vehicle, are readily absorbed by the stomach, and hence of quicker and more certain action. The physician carrying his medicine in fluid form will soon learn that the small dose is not only as good but better than the old doses, and that with the majority of drugs given for direct action, the standard gtt. x. to the half glass of water (3iv.), is the maximum. Prescribed in water in this way, medicines are not unpleas- ant, and the child will take them without objection. In dis- pensing, we have them bring one or two glasses half full of water, and a teaspoon, and prepare the remedy before the pa- tient. The patient sees that it is not unpleasant to the sight, 398 SPECIFIC MEDICATION. is clean, and the idea that medicine must be nauseous is e moved. The child takes its medicine without trouble, and indeed I do not recollect when I have had a case where the child required to be forced to take it. Using but small quantities of the stronger tinctures, an or- dinary pocket case will carry enough for a very large practice The pocket case I am using contains twenty-four four-drachm vials, and sixteen two-drachm vials, is of Eastern manufac- ture, and cost $3.50. It can be carried in the overcoat pocket, is sufficiently thick to sit upright in the buggy or on the table, corks all up--no unimportant matter in carrying fluids. The first row of twelve vials contains the essentials of practice the remedies in common use-Veratrum, Aconite Gelseminum, Lobelia, Belladonna, Rhus, Bryonia, Nux, Ipe- cac, Phytolacca, Asclepias, Macrotys, and we will give these a first consideration. Veratrum. This remedy is employed to slow the pulse, and is especially indicated when it is full and strong, the large pulse being the prominent feature. The deep red stripe down the center of the tongue-marked-is a characteristic symp- tom, and calls for Veratrum. Fullness of tissue-not con- traction-is found in cases where Veratrum gives its best re- sults It is a remedy in erysipelas with full tissue and bright color, both locally and internally, and in chronic disease with full pulse and increased temperature. Dose, gtt. v. to x to water 3iv.; a teaspoonful every hour. Aconite. This remedy is employed to slow the pulse and is especially indicated when it is small. It is the child's seda- tive, and is employed in the entire range of fevers and inflam- mations. It exerts a special influence on the throat and larynx, and is thus used in the treatment of quinsy and croup, being the most certain remedy for the latter we possess. It exerts its most marked influence on mucous membranes, and is thus used in acute disease of bronchial tubes or intestinal canal. In irritative diarrhoea, and in sporadic dysentery, we use it with the best results. Dose, gtt. iv. to v. to water 3iv.; a teaspoonful every hour. ▼ MY POCKET CASE. 899 Gelseminum. This is the remedy for irritation of the nerve centers, marked by flushed face, bright eyes, contracted pupils, and increased temperature, The dose will vary from the frac- tion of a drop to five to ten drops. Belladonna. This is the remedy for congestion, especially of the cerebro-spinal centers. The indications are dull eyes, dilated pupils, and somnolence, or coma. We add five drops to four ounces of water, giving a teaspoonful every hour. Lobelia. This is the remedy for the oppressed pulse, sense of weight and oppression in præcordium or chest, and, in ob- stetric practice, in rigidity of os and perineum, with fullness of tissue, and in inefficient pains with sense of oppression. It is especially the remedy in asthenic bronchitis of the child, with increased secretion. In ordinary cases we add ten drops to four ounces of water, and give a teaspoonful every hour. In obstetric practice we give it to slight nausea; and in pul- monary and cardiac congestion, a full dose of half a tea- spoonful. Rhus Tox. This is especially an epidemic remedy, and in some years will be in constant use; in others we will have but little occasion for it The indications are-frontal pain, especially in the left side and orbit, sharp stroke of the pulse, bright flush on left cheek, or in spots on the surface, burning pain in the part, especially superficial, and a peculiar redness of the papillæ of the tip of the tongue. We add two to five drops to four ounces of water, and give a teaspoonful every hour. - Bryonia. This is a remedy for serous membranes, in rheu- matism, and diseases of the parenchyma of the lungs. The indications are-frontal pain, extending to the occiput, right cheek flushed; pain constant and severe, but without sharp- ness; pulse of good size and steadily vibratile; cough att led with lancinating pain, and in rheumatism a steady teusive ache. Five drops are added to four ounces of water, and given in doses of a teaspoonful every one or two hours typhoid disease it must be given in smaller doses and with care. In 4:00 SPECIFIC MEDICATION. ན་ Nux Vomica. This is the remedy for nausea and vomiting if the tongue shows atony, for colic if the tongue is broad and pallid, for atony of the liver and associate organs, for habitual constipation, to improve the innervation from the spinal cord, and in every case where there is abdominal pain pointing at the umbilicus. A yellow sallowness of skin and about the mouth, is an indication in chronic disease. Two to five drops are added to four ounces of water, and given in teaspoonful doses as often as necessary. Ipecac. This is especially the remedy for acute disease of the mucous membrane of the intestinal canal, whether diar- rhoea or dysentery. It is an excellent remedy for nausea when the tongue is contracted, or elongated and pointed, and it is a prominent remedy in the treatment of infantile pneu- menia. We generally employ it associated with Aconite. Five to ten drops are added to four ounces of water, and given in teaspoonful doses every hour. Phytolacca. This is the remedy for mammary irritation and inflammation, for the sore mouth of the nursing child, for some cases of nursing sore mouth, sub-involution of the ute- rus, enlargement of the sub-maxillary and cervical lymphatic glands from sore mouth and throat, and for diphtheria. It is also an epidemic remedy. The most prominent indication for it in ordinary cases is a pallid, somewhat leaden colored tongue, very little coated, and looking slick, as if coated with some glutinous material. The dose varies from the fraction of a drop to ten drops. Asclepias. This is the diaphoretic, and is associated with the sedatives when an increased action of the skin is required. Macrotys. This is the remedy first thought of in rheuma- tism and rheumatic neuralgia. It is the remedy for unpleasant sensations in the pregnant uterus; for false pains, and to aid true ones. It is undoubtedly a partus preparator whenever the woman is troubled with unpleasant sensations in the last months of pregnancy. It is also a valuable remedy to correct the wrongs of menstruation, relieving pain, and looking to- ward normal functional activity. We find the small dose MY POCKET CASE. 401 much more certain than the large, and rarely add more than ten drops to four ounces of water, giving a teaspoonful every hour, or as often as required. I do not claim that my pocket case is better than many oth- ers, indeed it is not as good as some, but still it serves my present purpose. I was looking at a neighbor's a few days since it was much nicer and contained 120 remedies-but he was a Homœopath. By-the-by,why should Homoeopaths have things nicer than Eclectics? I want to know. But then again, it is decidedly nicer than an "old-fashioned Eclectic's," that I noticed a few weeks ago; it contained six dirty bottles, a few paper packages of powder, and a rag containing some out- landish mixture, altogether smelling like the "last rose of Summer," or a bad case of cholera morbus. We want nice medicines, in clean bottles, and in a clean, pleasant looking case. My second row contains twelve bottles, and these may be called incidentals to a good practice. They are Apocynum, Pulsatilla, Baptisia, Collinsonia, Drosera, Arsenicum, Cheli- donium, Cuprum, Podophyllin, Quinia, Ferrum, and Carbo- Veg. Apocynum. This is a remedy usually thought of in dropsy. The special indication for it in other cases is fullness of cel- lular tissue, oedema. It is one of the prominent remedies in rheumatism, rheumatic neuralgia, disease of joints, disease of mucous membranes, and always characterized by atony of the sympathetic nervous system,-the special indications above named being present. Add gtt. v. to xv. to water 3iv.; a tea- spoonful every two hours. Pulsatilla. This is the remedy for "nervousness," especi- ally when associated with disease of the reproductive organs or function. Fear of impending danger, dizziness, nervous dysphagia, unrest, and tendency to look on the dark side, are among the indications. It exerts a special influence upon the reproductive organs of both male and female, controlling sexual excitement in both, and is a prominent remedy to restore normal menstrual function, and to relieve some unpleasant- 34 402 SPECIFIC MEDICATION. nesses during gestation. Add gtt. v. to xxx. to water Ziv.; teaspoonful every two to four hours. Baptisia. This is one of our most important remedies, and should have been in the first list. It is the remedy for cynan- che maligna, and for any disease that gives this peculiar odor. It is indicated by fullness of mucous membranes, tongue, fauces, pharynx; by deep coloration of tissue, not red; also in typhoid disease by a continued moist pasty fur on a tongue of normal redness. It is an epidemic remedy, and, as in the present year, will cure typhoid fever, typhoid dysentery, ty- phoid pneumonia, typhoid sore throat, typho-malarial fever- or indeed typhoid anything. Add five drops to four ounces of water; give a teaspoonful every one or two hours. Collinsonia. This is the remedy for hemorrhoids, with a sense of heat, burning or constriction in the rectum. It is a remedy for diseases of digestion, functional diseases of the urinary apparatus, and diseases of the reproductive organs, if the above symptoms present. It is a remedy in diseases of the respiratory apparatus, when the irritation points in the larynx, with change in the voice, or inability to use it without irrita- tion. Add gtt. v. to xx. to water iv.; a teaspoonful every two to four hours Drosera. This is the remedy for the cough of measles, and all coughs that resemble it; and in many cases of whooping cough. Add gtt. v. to xxx. to water 3iv.; a teaspoonful every four hours. Arsenicum (Fowler's Solution). This remedy is not in common use. I employ it in those rare cases of malarial dis- ease, in which the pulse is soft and feeble, the skin relaxed, the extremities cold, and the tongue pallid and expressionless. Possibly these are the best indications in any case, though there is a peculiar incurved tongue, thick in the center, of a bluish leaden color, that is a prominent indication; and in phthisis a dead, inelastic skin that calls for it. Dose, from the fraction of a drop to two drops. Or- Chionanthus Chionanthus exerts a specific influence upon the liver, and is the remedy for jaundice. In ordinary acute MY POCKET CASE. 408 or chronic disease, if the eyes show the yellowish tinge, or if the patient complains of pain in the region of the liver, we employ this remedy. The dose is ten drops every three hours. Chelidonium, Whilst in some seasons, and in some locali- ties, this will be a useful remedy, in other seasons and places it will hardly be called into requisition. Fullness of right hypochondrium, dull pain in the shoulders, and a brownish sallow complexion, with dull leaden tongue, are the indica- tions for it. Add gtt, x. to xx. to water iv.; a teaspoonful every three hours. Cuprum. Copper is the blood-maker after exhaustive dis- charges, as uterine hemorrhage, hemorrhage from the lungs and kidneys, profuse diarrhoeal discharges etc. It is also a remedy in those cases of debility simulating these just named. In Asiatic cholera and some choleraic diseases, these appear- ances will present with or before the first discharges; in these copper is a remedy. a remedy. In some menstrual lesions we observe the same symptoms, and use copper. I use Rademacher's tincture, gtt, x. to water iv.; a teaspoonful three or four times a day. Or- Dioscorea. Dioscorea is a specific for bilious colic, and we also employ it in acute disease where abdominal pain and ten- derness are prominent features. It is a valuable remedy in the early stage of puerperal peritonitis, and especially valua- ble in the treatment of typhoid fever when there is tenderness on pressure and tympanitis. Podophyllin. This is a stimulant to the solar sympathetic. It is indicated by full tissues, full veins, full tongue, and by dirty pallor of surface. In an ordinary season I should carry granules made of Podophyllin gr. 1-20, Phosphate of Hy- drastia gr. 1-4. In some seasons, and in malarial localities, when the full influence of the drug is desired, pills of one- half grain. Or a trituration of one to one hundred for the summer diseases of childhood. I need hardly say I should prescribe it in any disease showing the above indications. Quinia. The use of this drug is so common and well known as an antiperiodic and nerve stimulant, that I need 404 SPECIFIC MEDICATION. but give the condition in which it may be expected to act kindly. A soft, open pulse, a soft skin, a moist, cleaning tongue, and absence of nervous irritation. Ferrum. As Iron is in such common use, every one should know how to use it. I give it when there is bluish coloration, and especially when there is dull pain in the back of the head. Rademacher's tincture, or tincture of muriate, are the best preparations, though in some seasons metallic iron will be better. Add gtt. xx. to water 3iv.; give a teaspoonful every one, two, or three hours. Or— Uvedalia. This remedy acts directly upon the spleen, and it is not only employed as a specific in the treatment of "ague cake," but it may be used in enlargements of the spleen from any cause. We also employ it as a remedy for the removal of low inflammatory deposits. The dose will range from one to twenty drops. And we employ an ointment of Uvedalia as a local application. Carbo- Veg. This is the remedy for passive hemorrhage from any part of the body; the remedy for hemorrhage in typhoid fever, and the remedy for the hemorrhagic condition in all typhoid disease. I have used it in uterine hemorrhage (not post partum), in hemorrhage from the lungs, bowels, kid- neys, and nasal passages, with most satisfactory results. It is a valuable remedy in typhoid conditions, with moist tongue, and tumid abdomen. I employ the first decimal trituration (one to ten.) I do not propose to change the pocket case of all my read- ers, nor to advance any thing specially new with regard to remedies; yet if it stimulates a removal of old and bad smell- ing pouches, and suggests additional agents, this article will have served its purpose. As a matter of profit, I am satisfied that money expended in nice medicine cases, nice medicines, and nice surroundings to the physician, will yield an excellent interest. We have had two rows of twelve each, and we designated them as necessities and incidentals; and probably some prac- titioners could do very well with these. We add a third row MY POCKET CASE. 405 of sixteen bottles, and as we have no special name for this row, let us designate it as and-so-forth. This list may vary at different seasons of the year, and in different localities, but now it shall consist of Cactus, Apis, Graphites, Viburnum, Sticta, Boletus, Eupatorium, Ergot, Permanganate of Potash, Morphia, Santonine, Hydrastia, Nitrate of Sanguinaria, Eryn- gium, Natrum Nit., Rheum, and Phosphorus. Cactus. The common idea is that Cactus is the remedy for heart disease, and so it is if there is irritability with feeble- ness, the quick movement without strength. But I do not restrict its administration to cases of heart disease; given, the quick movement without strength, and I would prescribe it in a case of fever, inflammation, or functional disease. The dose will vary from 3j. to gtt. v, to water 3iv.; a teaspoonful every four hours, or more frequently in the small dose. Apis. The tincture of the honey-bee is an excellent rem- edy if the diagnosis is well made. Given, the peculiar burn- ing pain that one associates with the sting of the bee, and I should think of this remedy. Burning pain with itching in the urethra, in the bladder, or any part of the surface, is met by Apis. I usually add gtt. v. to water 3iv.; a teaspoonful every two or three hours. Graphites. This is a remedy highly valued by the Homo- opaths, and I use it occasionally in diseases of women. Sen- sation of fullness in the pelvis with watery menstruation, thin leucorrhoeal discharge, dull eyes, sallow, expressionless face, dirty skin, are very good indications. I use the first dilution, gtt. v. to water 3iv.; a teaspoonful every three hours. Viburnum. This is one of our most valuable remedies, and should have a wide use. It is the remedy in habitual abor- tion, in cases where the pregnant woman suffers pains at the periods for the monthly flow; for tensive, cutting pains in the last weeks of pregnancy; for severe cutting after-pains, and in many cases of dysmenorrhoea. It has other uses, but we have not space to give them a consideration here. I add gtt. x. to water ziv., and give a teaspoonful every one, two, or three hours. 406 SPECIFIC MEDICATION. Sticta. This is a remedy I value highly, and in some sea. sons it has quite an extended use. It is a remedy for cough when there is pain in the chest extending to the shoulders, the neck, or back of the head. The special symptom indica- ting it is pain in the shoulders (usually the right) extending up the neck to the occiput; with this pain marked it has seemed to me it would cure anything. This winter it has been a prominent remedy for the cure of rheumatism. The Sticta belongs to a class of agents, the Lichens, which deserve care- ful study. Boletus. The Boletus is not in common use, and yet I think it one deserving study. I employ it in cases other than ague, in which there are recurring chills or chilly sensations. It is a remedy for ague, and in some seasons it will be found quite as certain in its action as Quinine. Add gtt. v. to water 3iv.; a teaspoonful every two or three hours. Eupatorium. Of course if we were using this agent in the olden way, we could hardly carry it in a two-drachm vial. I administer it in the small dose in cases of fever or inflamma- tion where there is marked pain in the bones, and throbbing pain in the head; pulse full, but without distinctness of wave. Add gtt. v. to water 3iv.; a teaspoonful every hour. Ergot. I employ Ergot for a use similar to Belladonna. There is dullness and oppression of the brain, but without the tendency to sleep; in a further advanced stage, coma. It is especially indicated where there is deficient spinal innerva- tion. The dose will range from the fraction of a drop to ten or twenty drops. Permanganate of Potash. I carry this remedy as a local application for phlegmous showing enfeebled capillary circula- tion, and as a dressing to open wounds when the pus is fetid and ichorous. Ten grains to the ounce makes a dressing for the abortion of a phlegmon; ten grains to one drachm in a pint of water makes an excellent antiseptic dressing. Morphia. Do not use Morphia as a narcotic; that is, the dose of the medicine as I use it is always stimulant. I em- ploy it as a stimulant when the pulse is small, frequent, and MY POCKET CASE. 407 the waves of blood short. The artery seems like a vibrating thread. Though the patient may be restless and sleepless, there is no inclination to wandering of the mind. I use War- ner's granules, one-eighth grain; one being a dose. Santonine. I am not sure but the Santonine had better be triturated with Podophyllin, in numerous sections of country, as its principal use will be as a worm medicine. For this bottle the proportions may be-R Santonine, Sugar of Milk, aa. 3ss.; Podophyllin, gr. ij. The dose of the trituration would be one grain for a child two to four years of age. As a remedy for retention of urine in children, it would be better in many cases with the Podophyllin out, and yet in this form it will serve the purpose. Phosphate of Hydrastia. I employ the phosphate because it is the most soluble, as well as the best preparation of the Hydrastis. One to two grains to Water 3iv., makes a good appetizer and tonic. One grain to the ounce is an excellent collyrium, gargle in sore throat, wash for sore mouth, or in- jection in gonorrhoea or leucorrhoea. Used in these small quantities, the remedy is cheap, portable, and easily dispensed. Nitrate of Sanguinaria. Wm. S. Merrell & Co. introduced. this salt to the profession, and thus far it has proven the most available preparation of Sanguinaria. The indications for its use in colds, bronchial disease, etc., are a sense of fullness in the upper part of the thorax, and a seeming difficulty in draw- ing a full inspiration. It is an admirable remedy in asthenic bronchitis, and humid asthma. A sense of burning and con- striction of the throat is also an indication. It is a valuable remedy in diseases of the stomach and upper intestinal canal with increased secretion of mucus. Be careful not to make the dose too large-one grain to four cunces of water is suffi- ciently strong; dose a teaspoonful. Rheum. I employ a tincture of Rhubarb to relieve irrita- tion of the stomach, and to aid digestion. Add gtt. x. to water 3iv.; a teaspoonful every one or two hours. Eryngium. This is one of our most certain remedies for diseases of the bladder, urethra, prostate gland, and some 408 SPECIFIC MEDICATION. wrongs of the reproductive organs of women. The indications are burning pain with tenesmus in the bladder or urethra. It has other uses, but I prefer to reserve it for this. Nitrate of Soda. I employ Nitrate of Soda in cases similar to those calling for Nitric Acid. Violet color of the tongue is the indication; and whilst I should use Nitric Acid if the color was deep, I should use Nitrate of Soda if the color was light. Phosphorus. I employ the tincture of Phosphorus for two purposes to arrest inflammatory processes in the lungs, and to arrest low grades of inflammatory action in kidneys, pros- tate gland, testes and ovaries. Languor, debility, impairment of mind, and want of acute evidences of disease in the part, may be regarded as the indications. Thus we have filled up our three rows of forty bottles, and yet the reader will find that some favorite remedy is left out. But there are many in that are not in common use, and they may be exchanged. Some remedies that we value highly can not be carried in a pocket case. We want Muriatic, Nitric, and Sulphurous Acids, Phosphate of Soda, Sulphite of Soda, Bicarbonate of Soda, a convenient emetic, and these are more or less bulky and difficult to carry. We have filled up our pocket case, and left some of the es- sentials out, and I hardly know how we will carry them. It is not so difficult to arrange for the bulky agents, Sulphite of Soda, Bicarbonate of Soda, Phosphate of Soda, Acetate of Potash, etc., as it is for the Acids, which are inclined to get out of the container, and do some unpleasant burning. How shall we arrange it?—with another pocket case of one row, ten four-drachm vials, or by increasing the thickness of our principal case one row? I will take it for granted that we must have another case, and we will make it of ten vials, with rubber corks, and we will have the manufacturer see that these vials are of extra strength. It is a pity that he can not devise a cork-retainer, like the modern soda-water bottle. If we have another case, it will be necessary to have a nice sack, very like an officer's MY POCKET CASE. 409 haversack, to carry them in, with instruments and other things or instead of this, a very nice hand satchel. I saw a physician with one the other day, and it served the purpose and looked well. We commence this list with the acids, which are very im- portant remedies, and have well defined indications, and in some seasons will be in very common use. As Acids, the special indications are, deep-redness of mucous tissues or skin if blood shows freely. Here we may use Muriatic Acid, hard cider, or whey, and sometimes lemonade or other vegetable acids. Muriatic Acid. This remedy is indicated by the deep-red- ness of the tongue, contracted, with coatings of a brownish color, inclined to grow darker as the disease advances. It is added to water so as to make a pleasant acid drink, and given ad libitum. Nitric Acid. This remedy is not employed for the general purposes of an acid, It is a typical specific, having a positive indication and a most certain action. The indication is a violet coloration of tongue, and of other parts where blood shows freely. In the best marked cases the violet color seems but a film upon the surface, and you seem to look through it to the natural, or rather deeper than natural color of parts below. I usually prescribe it in the following proportion, when I send the prescription to a drug store: & Nitric Acid, gtt. x to gtt. xx; Water, Syrup, aa. 3j.; a teaspoonful in water every three hours. Sulphurous Acid. This is a feeble acid, and is not used for the general purposes of an acid. It is one of our group of antiseptics, and is indicated by full tissues and dirty color of coatings of tongue, and of other secretions and excretions. The dose is from five to thirty drops in a little water. Tincture of Muriate of Iron. In our other case we had a preparation of Iron, Rademacher's Tincture, or Iron by Hy- drogen; in this it is well to have the old standard. It is the remedy for erysipelas when the redness is deep and the pain has not so much of the burning character. It is a most 410 SPECIFIC MEDICATION. excellent remeay in diseases of mucous membranes, when the tongue, fauces or throat, shows the glistening, deep-red, ery- sipeloid condition; and in any disease in which either skin or mucous membranes show the characteristic color. It is a most excellent restorative in some conditions of both child and adult. I especially prize it in the first. Nutrition is impaired, digestion poor, tissues relaxed, tongue shows more the usual deep-redness, with possibly a tinge of blue ally add gtt. x. to xx. to water and syrup to make 3ij. Dose, half to one teaspoonful three times a day. Chlorate of Potash. This is the antiseptic, where there is a fetor resembling an unpleasant lochial discharge, or decom- posing animal matter. The fetor of cynanche maligna is sometimes a very striking dissecting room smell. Chlorate of Potash is especially the antiseptic in puerperal diseases, and my readers are all familiar with its common application in simple sore throats, and other diseases of mucous membranes. The dose will vary from one to five grains, and as a local ap- plication, 3j. to water Ziv. Sulphite of Soda. Sulphite of Soda is one of our most valuable remedies, as an antiseptic and a destroyer of the germs of low animal and vegetable organisms. The indication for its use is a dirty, pallid tongue. We use it in doses of from one to twenty grains, every three hours. Bicarbonate of Soda. The physician will find this one of his most useful remedies in some seasons, preparing the way for the kindly action of other agents, or sometimes effecting a cure itself. The indication for its use is pallor of mucous membranes-a broad, pallid tongue. It is not necessary to use it in large doses. Add it to water in small quantity so as to make a pleasant alkaline drink, and let the patient have as much as he desires. An Emetic. What will give us the best emetic in small compass? Suppose we say-R Lobelia Seed, powd., 3iij.; Ipecac, 3j.; Capsicum, gr. x. Mix. Make two-grain powders, and give one every ten or fifteen minutes in a wine-glass of warm water. If the influence is to be prolonged, lessen the MY POCKET CASE. 411 quantity of water, and increase the distance between the doser If it is a case where an acetous emetic would be preferable acidulate the water with vinegar. Sesqui-Carbonate of Potash. This old-fashioned remedy should not be forgotten. It is the very best injection to re- move the debris of tissue in an abscess, and to stimulate the restorative process, as it is the very best escharotic in caries of bone. It is the remedy for carbuncle, though a seemingly severe one. I use it early, injecting the structure thoroughly from one or more openings, with a saturated solution; and though it makes the patient dance, this is more than compen- sated by the relief from pain that follows in ten or fifteen minutes. No. 10.-Please fill this bottle to suit yourselves, and thus complete the little case. We have an abundance of remedies, and every reader will probably have been looking for a vacancy for some favorite. I have done the best I could for the case, in the small com- pass of this article, and if any thing has been left unsaid, please add it. If we all live five years we will want to renew our cases and our studies, and we will probably be able to make one with a hundred remedies instead of fifty. INDEX. Abies Canadensis... Acetate of Potash.... Achillea Millefolium......... Acids.... Aconitum Napellus.... Acta Alba…. …………………. 54 .... 210 54 57 ..55, 399 59 Actaea Spicata ……….. 59 Adansonia Digitata........ Administration of Medicines...... Esculus Glabra.......... 59 24 59 Esculus Hippocastanum ... 60 Athusa Cynapium.. 61 Agaric 61 Agaricus Muscarius.. 63 Agave Americana.. 64 Agrimonia Eupatoria..... Ailanthus Glandulosa.. Alisma Plantago. . Alkalies........ Alkaline Sulphites.... Aletris Farinosa... 64 65 65 65 47 . 67 Alnus Rubra………………… Aloes 67 .... 68 Alstonia Constricta " Scholaris..... Ammonium, Bromide of..... Iodide of...…………. 4 Muriaticum.. Ampelopsis... Amygdalus Persica........ Amyl Nitrate.………………….. . 68 69 70 70 71 71 71 . 72 414 SPECIFIC MEDICINES. Anagallis Arvensis. 73 Analysis of Disease..... 11 Anemone Nemorosa 73 Antimonii et Potassii Tartras.. 74 Apis Mellifica…………….. Apple-tree....... Apomorphia...... 83, 405 ........ 218 74 269 Appendix....... Apocynum Canabinum.... Aralia Hispida…………………………. Arbor Vitæ...... Argentum Nitricum.. Arbutus... Aranea Diadema... Aristolachia Serpentaria……….. Arnica Montana.………………………….. Arsenicum... Arum Triphyllum Artemesia Absinthium. Artemesia Santonica.... Asclepias...... Asafoetida....... Asclepias Tuberosa..... Ash......... Aspidum Filix Mas. Atony of Stomach.. ..... Atropia Belladonna………………. Aurum....... Baneberry.. Baobab....... Balmony.... Baisam Apple..... Bayberry... Balsam of Peru. Baptisia Tinctoria.... Barberry.... Barii Chloridi Barium. ......... Belladonna.... .74, 401 76 .........8, 25 76 .127 77 77 77 78, 402 82 82 82 83 84 84 ....139 85 40 85 87 59 59 ......106 .183 184 ....185 ...88, 402 91 89 89 85, 398 INDEX. 415 Beth Root..... Bebeerinæ Sulphas Benzoic Acid..... Benzoate of Soda....... CL of Lithia...... Berberis Vulgaris. .259 89 90 90 91 91 Best Menstruum for Medicines. 28 Bittersweet. ..246 Bismuth..... 91 Bidens Bipinnata……. 92 Blessed Thistle... ...102 Blue Cohosh ………………... Black Hellebore.. Black Root Black Cohosh..... Black Alder.. ...103 ...152 .167 ..174 ..213 Black Locust. ...226 Black Willow.... 230 Blood Root...... 232 Bladder Nut... ..248 Blood Poisons…….. 47 Black Haw 266 .266 Blue Violet........ Boldo......... Boletus Laracis………. Boneset. Borax...... Bromine... Bromide of Potassium...... Bromide of Ammonium.. Bryonia......... Bursa Pastoris...... Brook Lime.... Buckeye....... ...... 92 62, 406 ..132 92 93 93 70 ..94, 399 94 .265 59 Butternut Burdock..... Button Snakeroot..... Buckhorn Brake...... Bugle Weed.. .... ... 162 166 169 ... 193 171 416 SPECIFIC MEDICINES. Buckthorn. Cactus Grandiflora…………………. Cadmii Sulphas..... Cahinca...... Calcii Chloridum..... Calendula...... Calx.......... Cases........ Cannabis Sativa......... Camphor.... Cantharis Vesicatoria...…….. Capsicum Cayenne Pepper…..... Cardiac Stimulants..... Carbo-Ligni..... Carbolic Acid........ Carduus Benedictus..... Cassia Acutifolia..... Castanea Vesca Castus Indicus... Catalpa......... Caulophyllum.. Catnip. Cascara Sagrado.. .... .... .... .... ..... 222 ...94, 405 96 96 97 .97 98 ...321 98 99 99 99 99 45 100, 404 ...101 .....102 ....102 ....... ...103 ....103 ... 103 ..103 ..186 223 Calabar Bean...... ...201 Ceanothus.... 104 Celandine........ ....106 Cerii Oxalas………. 105 Certainty in Medicine...... ..286 Celastrus Scandens........ ....105 Centaury 229 Century Plant......... 64 Chamomilla ... .105 Chaulmugra Oil.. ...105 Chirayta..... Chiretta... ...106 ..106 Chelone Glabra .... Chelidonium Majus... Chickweed..……….. 106 106, 403 73 INDEX. 417 Chloride of Lime……….. Charcoal........ Chestnut.. Chloride of Zinc......... Chionanthus Virginica... Chimaphilla Umbellata. Chloroform..... Chloral Hydrate.... Cholera Infantum.... Chlorate of Potash.......: Cimicifuga Cinchona. 97 100 103 ..267 Cistus Canadensis............ Circulation.... Cinnamon. Citrus Limonis.. Cinquefoil.... Cleavers.. Club Moss... Clematis Virginiana………. Classification of Medicines……….. Cohosh White. Cotton........ Coffee Tree………………….. Colt's Foot. ………. Couch Grass.... Comfrey.. Cod-liver Oil....... Coffee......... Colchicum Colocynth... Collinsonia.. Coca...... Coto Bark Comptonia Asplenifolia....... Condition of Stomach. Condition of the Digestive Organs... Conservation of Life................. .......…………………………… Continued Fever......... …………………..107, 402 .109 109 ...110 359 211, 410 .....174 • ...219 .113 41 ...113 114 .212 .140 ... ..174 .114 37, 392 58 .146 ..150 .260 259 256 193 • • ..114 ..114 115 116, 402 117 ..117 ..117 39 17 .300 ..338 418 SPECIFIC MEDICINES, Convallaria Majalis..... ........118 Convallaria Multiflora...... ....118 Copper Cranesbill.... Crawley....... Crowfoot...... Crocus Sativus... Croton Tiglium.. Cubeba........ Cucumis Sativus... Cubic Nitre………………… Cuprum 120 144 ...216 221 ... 118 119 ... 119 119 190 120, 403 Curcas.. 121 ..122 ...122 ... …..122 Cyclamen...... Cydonium. Cypripedium Pubescens. Dandelion....…………. Daffodil..... Damiana... Daphne Indica....... Delphinium Staphisagria....... Disease, Analysis of...... Diagnosis, Specific Diervilla Canadensis....... Digitalis Purpurea....... Dioscorea Villosa...... • 257 186 ..128 ...123 ..123 11 14 124 …..124 125, 403 Dita Bark...……… …………………… Disease, Rule for Measuring... Digestive Apparatus, Condition of.. Difference from Homœopathy Differential Therapeutics of Aconite and Veratrum….. ….…………..... Dose of Medicine... Doctrine of Substitution....... Drosera Rotundiflora...... .. 69 17 17 .. 21 62 30 289 ...125, 402 Duboisa........ Dwarf Elder.... ... 126 76 ...361 Dysentery..... Elaterium..... ………………… Elecampane………………….. 127 158 INDEX. 419. Elder...... Epigas Repens...... Epilobium Palustre.... Erecthites Hieracifolius..... Ergota.... Ergot......... Erigeron Canadense.... .231 127 ..127 128 Eryodyction Glutinosum. Eryngium Aquaticum... Ergot of Corn.. Erythrophlæum. Ether Sulphuric. Eucalyptus..... Euonymus Atropurpureus.... Eupatorium Aromaticum......... Eupatorium Teucrifolium....... Eupatorium Perfoliatum.. Eupatorium Purpureum.. Eugenia Jambollina..... Euphorbia Hypericifolia..... Euphorbium........ Euphrasia Officinalis…………….. Euphorbia Corrollata…………………….. Evening Primrose............ Eyebright...... Elements of Uncertainty in Medicine………….. Elements of Certainty in Medicine...... Epidemic Constitution of Disease.... Excretion..... Fagonia Arabica. Ferrum...... Feverfew Fever, Intermittent..... แ Remittent "" Infantile.... (6 Continued.. Typhoid...... Fever Root... ……… ………………………………… Fever Bark........ ... .... 128, 406 ..237 ... 129 129 129, 407 260 ..130 .130 ..131 .. 131 ..131 ...132 ..132, 406 133 ..133 133 134 ...134 ..134 192 134 .....283 286 ..310 ... 20 ...135 135, 404 217 312 ....325 ..335 ..338 ....343 ... 259 68 420 SPECIFIC MEDICINES. Fireweed...... Figwort Filix Mas Fleabane Fly Agaric.. Fool's Parsley Fænum Græcum..... Frasera Carolinensis... Fraxinus Sambucifolia. Fringe Tree...………………. Fucus Vesiculosis Galium Aparine…….. Galangal...... Galega Officinalis……………. Gaultheria Procumbens.... Gelseminum. Gentian..... Genista Tinctorea.. Geum Rivale.......... Geranium Maculatum, Gerardia Pedicularia......... Gillenia Trifoliata.... Ginseng....... Glycerine Glecoma Hederacea....... Glonoine...... Gnaphalium Polycephalum....... Gossypium Herbaceum..... Good Nursing………….. Gold...... Golden Seal...... Golden Rod..... Granati....... Graphites.. Gratiola Officinalis.... Grindelia Robusta Ground Ivy...... Guaco ... Guarana.. • ...128 236 .......140 ....63 61 ..... 140 .139 .139 ..107 ...139 .140 .141 •••••• ... 141 .....141 142, 399 143 .:144 ..144 ... 144 145 .........145 ...194 145 .144 • 147 .146 146 24 87 ...154 .246 ..... .... .147 .148 .148 .148 144 .149 149 INDEX. 421 Guarea Trichilioides Guaiacum Officinale...... Guilandina Bonduccella..... Gymnocladus Canadensis.. Hardback...... Hamamelis Virginica, Hedeoma Pulegioides.... Hemlock.......... Heuchera Americana... Helleborus Niger.... Helonias Dioica Hepatica Americana Henbane......... Heracleum Lanatum. High Cranberry... Hieracium Venosum Honey Bee....... Honeysuckle Hoarhound Horse Chestnut...... Hydrastis Canadensis….... Hydrangea Arborescens.. Hydrocatyle Asiatica...... Hydrocyanic Acid..... Hypericum Perfoliatum... Hypophosphites...... Hyoscyamus Niger....... ... ....... Hypodermic Injection of Morphia... Ice Plant....... Ignatia.... Imperatoria Ostruthium ...... Indian Hemp..... Inula Helenium. Indian Physic………………….. Indian Cup Plant...... Innervation...... Intermittent Fever......... Infantile Remittent... Infantile Pneumonia... ... ...149 149 .150 150 247 150 .152 54 152 .152 153 ..153 ... ..156 ...154 .265 ...153 83 ...124 ..177 60 154, 407 ...155 155 ..156 156 ....200 156 .196 ... .182 .....157 158 ...74, 98 ....158 145 ..241 ..... ... 50 312 ..335 ..357 422 SPECIFIC MEDICINES. Iodine. Iodide of Potassium...... แ Sodium.......... Ammonium.... Starch...... Ipecacuanha.... Ipomoea Jalapa...... Iris Versicolor…..………………. Iron....... .... ..158 ...158 159 159 .....159 160, 400 161 ..161 .135, 408 Iron Wood…..... 192 Iron Weed...... .265 Irritation of Stomach.......... ......... 39 Jaborandi..………. ...162 Jacob's Ladder...... ........206 Jalap...... Jatropha...... ....161 ........121 Jamestown Weed. Jeffersonia Diphylla Juglans Cinerea………….. Juniperus Sabina... Kalmia Latifolia..... Krameria Triandra.. Lady's Slipper....... Laburnum......... Lac........ Lactuca Virosa. Lappa Officinalis.... Larix Americana. Laurus Sassafras….... ..251 ..163 .... ...162 ....163 .....163 ...164 ...122 ..164 ........165 ..165 166 ...166 .....166 Lavandula Vera ..167 Lavender.......... .... ....167 Labrador Tea. ..167 Laws of Cure...... 21 Ledum Latifolium.... Leptandra Virginica......... Lettuce. ...167 ...167 165 Lemon. Leptandrin...... ……. 1 14 ...168 Lemon Juice...... ...172 INDEX. 423 Leonurus Cardiaca.... Liatris Spicata…… Lime...... Liquidambar Styraciflua.. Ligustrum Vulgare Linaria Vulgaris…………. Lily of the Valley.......... Linden....... Lion's Foot... Liriodendron Tulipifera.. Liverleaf... .. Life, Renewal of……...... Lobelia Inflata... Lungwort.... Lupulina ... Lycopodium Clavatum.. ... .... .... ...172 ... 169 .98 ....169 .........172 ......173 ..118 ..258 ..186 169 ... 153 18 ....170, 399 .216 .173 .174 Lycopus Virginicus ...171 Maguey..... 64 Macrotys Racemosa ...174, 400 Magnesia, Sulphate of...... Marsh Rosemary... Magnolia..... ...176 .......249 ..177 Male Fern.. .85 Marrubium Vulgare......... .....177 Maruta Cotula… ……………… ……………… ....178 Marsh Trefoil. ...180 Manganesii Sulphas….. ..178 Mangold..... 97 Malaria.... 49 Mayweed. Masterwort. May Apple...... Melilotus Officinalis..... Mercury....... ...178 154, 158 ...205 ..178 .179 Menispermum Canadense.. Measuring Disease……………………… Menyanthes Trifoliata ……………. ……… …………………………………………… Methonica Gloriosa. ……………. ……………………… ……………………… Mentha Viridis……………………….. .180 180 ..181 ..181 .... 15 424 SPECIFIC MEDICINES. Medicines, Administration of…..... แ Should act slowly...... Pleasant..... Dose of... Proportion of........ (L Measles...... Mitchella Repens. Milk......... Mimulus Pilosa..... Monotropa Uniflora...... Momordica Balsamina..... Monesia...... Monkey Flower...... Morphia.... Motherwort... Muriate of Ammonia...... Mullein..... Myrica Cerifera..... Myristica Moschata.. Myroxylon Peruiferum.... Myrrha...... Nabalus Albus....... Narcissus Pseudonarcissus Nettle...... Nepeta Cataria……. Nightshade. Nicotiana Tabacum………….. 24 .... 26 29 30 31 ....348 .182 .....165 181 182 ..183 .183 181 .196, 406 .... 172 183 ....264 .184 185 ..185 .....185 .186 .186 ...260 ...186 241 ....186 76 Nitrate of Silver..... Nitric Acid....... Night Blooming Cereus Nitri Spiritus Dulcis. Nitro-Glycerine...... Nitrate of Soda....... Nosology...... Nuphar Luteum Nux Vomica..... Nutmeg........ Nutritive Processes...... Nymphæ Odorata....... ....188, 409 94 ....190 .....147 ..190, 408 .... 11 ..191 252, 400 ..185 53 .191 INDEX. 425 Objects of Treatment..... Obstetric Remedies. Obscure Cases, Enathe Phellandrium Enothera Biennis. Office Pharmacy. Oleum Tiglii... Oleum Morrhuæ.. One thing at a time......... Opium....... Opposition to Disease... · ... 38 ....378 ....306 192 192 35 ....119 ... 193 . 25 ...195 9 Opponens Opponenda. 22 Origanum Vulgare...... Osmunda Regalis..... Ostrya Virginiana...... Oxide of Zinc......... ......193 193 .192 268 Pancreatin .... ....195 Papaver Somniferum. ......195 Partridgeberry....... ...182 Pareira Brava..... ...195. Pastinaca Sativa...... ........197 Parsnip ...197 Passiflora Incarnata.....…………. .........197 Passion Flower........ Pain and its Treatment. .......197 ..303 Parsley... ..199 Penthorum Sedoides.... .....197 Peach Tree... 71 Percolation... Pepsin.. 36 198 Peroxide of Hydrogen........ .... 199 Petroselinum Sativum... ..199 Pennyroyal.. Petroleum Pepper, Black……………………… Permanganate of Potash…………………….. Pipsissewa... Pix Liquida.... Piper Nigrum.. ...152 .. 199 ....203 208 ...........203 ..109 .203 426 SPECIFIC MEDICINES. Phosphorus..... Phosphate of Soda........ : Physostigma Venosum................ Phytolacca Decandra......... Physical Properties of Remedies..... ...200, 408 .201 .......201 202, 400 ... 34 Pharmacy, Office…………………………… Plumbago..... Pleasant Medicines.......... Plantago Major..... 35 148 298 ... 204 Plantago Cordata.. ..204 Pleurisy Root.. 84 Pneumonia, Infantile....... ...357 Pocket Case... ....296 Poke......……………………. 202 Post Partum Remedies.......…. ………………….. ...382 Poison vs. Medicine....... 292 Podophyllum.. .205 • Poison Oak…... ..225 Podophyllin.. 206, 403 • Polemonium Reptans.. ..206 • Polyporus Officinalis….. 62 Polyporus Pinicola.... 62 Polygala Senega.. .206 Polygonum Punctatum... .....207 Polypodium Vulgare...... ....207 Polytrichum Juniperinum........ ...207 Pomegranate Bark........ ...147 Populus Tremuloides ..208 Poplar......... Potassa.. Potassæ Permanganas…………... แ Sesqui-carbonas Potassii Acetas Bicarbonas (( Chloras.......... Ferrocyanuretum. Potentilla Canadensis.... Privet...... Prickley Ash....... ...208 ...208 .208, 406 ......209 210 .210 .211 . 211 : ...212 172 …….. 267 INDEX. 427 Primula Officinalis………….. Prussiate of Potash..... ..212 .211 ....212 Primrose... Prinos Verticillatus......... Propylamin..... Proper Food.…………….. Prunus Virginiana….. Ptelia Trifoliata.... Pteris Atropurpurea.. Pterospora Andromeda......... Pulmonaria Officinalis..... Pulsatilla...... Pyrethrum Parthenium Pyrola Rotundifolia………….. Pyrus Malus... Quercus Rubra..... Quinia Sulphas... Quinine....... Quince Seed.... Queen of the Meadow...... Rattlesnake Weed...... • ... 213 ...213 19 ...214 ...215 ....215 ..216 ...216 216, 401 ....217 218 ..218 .....218 .....219 219, 403 .....122 133 ...153 Ranunculus Bulbosus ...221 Red Root ...104 Removal of worn-out Tissue.... 17 Retrograde Metamorphosis.... 52 Remedies in Diseases of Women ..385 Restoratives......... .....302 Remittent Fever..... ..325 (( แ Infantile....... ...335 Redwood.... Red Oak........ Red Clover Rhamnus Catharticus....... Rhatany. Purshiana.. Rheum Palmatum. Rhododendron... Rhubarb. .... Rheumatism... i . 149 ..218 ..258 222 ...223 ..164 223, 407 .. 224 ......223 ..352 428 SPECIFIC MEDICINES. Rhus Toxicodendron...... Rock Rose..... 225, 399 113 Rosin Weed... Robinia Pseudo-Acacia...... Rock Brake. Rumex Acetosella............. Rumex Crispus.. Ruta Graveolens... Rue...... Rule for Measuring Disease.. Rubeola... Sabbatia Angularis Salicin.... Salicylic Acid………………….. Salix Nigra...... Salvia Officinalis......... Sage........ Saffron..... Sambucus Canadensis.... Sassy Bark...... Sanguinaria Canadensis.. Sanicula Marilandica... Santalum Album.... Sandal Wood Oil....... Santonin........ Savin...... Sassafras ... Sarracenia Purpurea. Salt, common ………………… ... Scilla Maritima..... Scrophularia Marilandica... Scutellaria Lateriflora... Scullcap Senega.. Seven Barks………………….. ..... ... ...241 ...226 .....215 ..227 .... ....227 ..........228 ...228 ..... 15 .....348 229 229 ..229 ..230 231 231 118 231, 407 ...130 .232 232 ..233 ......233 82, 40? .........163 166 ....233 ...242 ...236 ....236 237 ..237 206 .....155 Secale Cornutum..... Sedation, Theory of..... Selection of Remedies..... Senna...... ••*- ..237 44 13 ......102 INDEX. 429 Sedum Acre Sempervivum Tectorum. Serpentaria......... Sepia Officinalis……... Senecio Aureus Sheep Sorrel... Sheep Laurel..... Similia Similibus .... ...239 ..239 ...238 ...239 ...240 ....227 ..163 21 Single Remedy.... .......16, 294 Silica..... 240 Silkweed... 83 Silphium Gumniferum…………….. ...241 • it Perfoliatum... Skunk Cabbage ... Smartweed...... Small Pox......... Sodii Chloridum.... 241 ..256 207 ....345 แ Sulphas... 242 .243 แ Sulphis..... Nitras.... Phosphas. Solomon's Seal.... Solanum Dulcamara. Nigrum..... Solidago Odora... Sophora Speciosa. Spanish Needles... Spilanthes Oleracea. Spanish Fly.... Spirea Ulmaria…......... Spider's Web.. Spongia Usta.... 243 ...190 ..201 ..198 ...........246 .........246 .....246 …………………...247 92 ...247 .99 ...247 77, 257 ........247 .:...181 Spearmint...... Specific Medication...... .277 "" Theory of............ 9 "" Study of....... of.............. .270 66 (( Some Phases of....... .273 "L Use of the Word..... Specific Diagnosis..... 10 14 430 SPECIFIC MEDICINES. Squill...... Strength of fluid Remedies...... Staphysagria...…………… Staphylea Trifoliata. Statice Caroliniana Stillingia Sylvatica Sticta Pulmonaria……………. Stone Crop....... Stone Root. Stramonium Stone Crop....... .... Strychnos Nux Vomica..... Sundew.... Sulphur... Sumbul..... Sulphate of Zinc.. Substitution, doctrine of.. Sulphite of Soda Sulphate of Soda..... Sulphurous Acid.. Sweet Spirits Nitre.. Sweet Guin Sweet Clover....... Symplocarpus Fœtidus. Symphitum...... Tag Alder.... ..236 • 33 • • 123 ....248 249 ...249 250, 406 238 ...116 • 251 197 .... 252 ..125 ... 254 ...255 268 ..289 243 243 ..... ... .244, 409 190 ..169 178 ……..256 ...256 67 Tanacetum Vulgare...... 256 Tansy... ....256 Taraxacum 257 Tartar Emetic........ 74 Taxus Baccata.... 257 Tela Aranea..... Teucrium Canadense...... Temperature.... Theory of Specific Medication.... (( Sedation... Thuja Occidentalis....... Tilea Europea... Tobacco...... 257 ...258 46 9 44 258 .... ...258 …………..186 i INDEX. 431 Trifolium Pratense Trillium Pendulum…….. Triticum Repens... Treatment of Pain...... Triosteum Perfoliatum. Tussilago Farfara Twinleaf......... Typhoid Fever Urtica dioica Ustilago Maidis... Uva Ursi...... Uvedalia Unicorn Root….... ..258 259 .259 388 .....259 .260 163 ..341 ..260 ...260 .261 .404 .....153 10 ... 283 ...261 ..261 .345 50 261 .264 ....265 .265 ..265 ....265 ...266 Use of the word Specific......... Uncertainty in Medicine.. Valeriana Officinalis..... Valerian..... Variola. Vegetative Processes.. Veratrum Viride. Verbascum Thapsus... Verbena Hastata....... Vernonia Fasciculata.. Veronica Beccabunga. Viburnum Opulus .... Viburnum Prunifolium.. Viola Pedata…….. Virginia Snake Root......... Virgin's Bower............ Want of Vital Power...... Waste and Excretion.... Water Avens........ Wafer Ash………….. Water Pepper Water Plantain ... Water Hemlock………….. Wahoo...... Water Eryngo.... ... .... ....... 266 77, 239 .114 ་ 42 .48-51 ..144 ...215 ..207 ..204 ..192 .131 ...131 432 SPECIFIC MEDICINES. White Cohosh....... White Pond Lily..... White Snakeroot... White Balsam…….. Wild Cherry... Wind Flower. Wild Indigo Wild Yam.......... ... Wild Hoarhound...... Wild Ipecac...... Wintergreen Witch Hazel…………….. .... 58 ..191 .........131 ....146 214 73 ........ 88 125 ... ...132 134 ... .141 ..150 Wood Sage......... Wormseed..... ..258 82 Yerba Santa....... Xanthium Spinosum.. Xanthoxylum Fraxineun.....………. ……. Yarrow...... Yellow Poplar....... Yellow Pond Lily... Yellow Dock.... Yellow Jessamine............... Yellow Parilla………………. Yew......... Zinci Chloridum.... ...266 .267 54 ......129 .....169 ...191 .227 142 181 ..257 ......267 Zinci Oxidum...... ..268 Zinci Phosphidum.... .268 Zinci Sulphas………………….. ..268 Zymotic Causes of Disease...... 47 UNIV OF MICHIGAN, FEB 24 1918 UNIVERSITY OF MICHIGAN | 3 9015 06555 3383 ed by Preservation PLEASE SIGN RIVE, AOONGOO KAD PIGHE NUMBER $ , '