#|||}||||}|]}}|{}} |||}|| | ſ | *||||||||}|| 3 9015 OO250 667 6 University of Michigan – BU HR *T**,№_ ^º(aeaeº~~~ …!!! :) T'ae.! **** -- wae * * ·,≤ ∞, ∞) ******--★ →*(…:….….…º, , ,ae, ,,,,,,.,:.,,, *** --~~~~(~~№№yſ&ÈÈÈÈÊÊË == --!!!--~~~, zī£.|-|- !■ *** ±±√¶www. HIKŌ!!!!!!!!!!!! №ſſſſſſſſſſſſſſſſſſſſſſſſ IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIŲJĮIIIIIIIIIIIIIIIIIIIIIIIIIIȚIIIIIIIIIIIIIIIºſlſtītſiſſſſſſſſſſſſ №.89 -!= <!-- ººººººººººº = ∞∞∞∞∞∞∞∞∞, ∞, ∞, ∞∞∞Rae'ſº:œ •• • • • • • • • • • • • • • • • • •∞ √.• • • • • • • ► ► ► ► ► ► ► = <!=\,(E. §§ Nº UV. Iſſºil. Nº. |U}\º.º.º. Nº. immunºminimum - Cº-º-º-º-º-º-º-º-º-º-º-º-º-º-º- TE șïİİİİİİİİİİİİİİİİİİİİİİİİİİİ t (2 / 0 º N / \ *~ ..) +. (e/O. 5 N 56 s T q M 5 tº TRANSACTIONS OF THE NEW YORKSTATE MEDICAL ASSOCIATION. COMMITTEE ON PUBLICATIONS. ALFRED L. CARROLL, M. D., of New York County, CHAIRMAN. JOHN W. S. GOULEY, M. D., of New York County. S. B. W. McLEOD, M. D., of New York County. JOHN SHRADY, M. D., of New York County. JOHN G. TRUAX, M. D., of New York County. PRINTED BY THE FLESS & RIDGE PRINTING COMPANY., FIFTH AVENUE, N. Y. TRANSACTIONS OF (Rokaº S. O'Lººkº, THE NEW YORK STATE MEDICAL ASSOCIATION, FOR THE YEAR 1892. VOLUME IX. : ; § EDITED FOR THE ASSOCIATION By OGDEN C. LUDLOW, M. D., OF NEW YORK COUNTY. PUBLISHED BY THE ASSOCIATION, 64. MADISON AVENUE, NEW YORK CITY. * { i : CoPYRIGHT, 1893, By THE NEW YORK STATE MEDICAL ASSOCIATION. C O N TE N T S. PAGE Officers and Council for 1891–92 . Committee of Arrangements for 1891–92 Officers and Council for 1892–'93 . Officers of the Branch Associations for 1893 List of Presidents and Vice-Presidents . . . . . . . . . List of Fellows registered at the Ninth Annual Meeting . . . List of Delegates and Invited Guests at the Ninth Annual Meeting Address of Welcome and Report of the Committee of Arrangements. By J. G. TRUAx, M. D., of New York County . . . . . . President's Annual Address. By JUDSON B. ANDREWs, M. D., of Erie County • e º e s e º e s - © e º 'º º º Preumotomy for Relief of Tubercular Abscess and Gangrene of the Lung ; Twice on the same Patient. Recovery. By JOHN BLAKE WHITE, M. D., of New York County . . . . . . . . . Traumatic Osteo-Arthritic Lesions which involve the Proximal Seg- ment of the Ankle Joint; Their Pathological Anatomy and Treat- ment. By THOMAS H. MANLEY, M. D., of New York County Muscular Traction for Hip-Joint Disease. By THOMAS M. LUDLow CHRYSTIE, M. D., of New York County . . . . . . . . Some Recent Cases of Appendicitis. By NATHAN JACOBSON, M. D., of Onondaga County . . . . . . . . . . . . . . . Ectopic Pregnancy. By HENRY D. INGRAHAM, M. D., of Erie County Antiseptic Waginal and Intra-Uterine Injections unnecessary, if not injurious, in the daily Practice of Obstetrics. By DARWIN COL- VIN, M. D., of Wayne County . . . . . . . . . . . The Palliative Treatment of such Cases of Cancer of the Uterus and its Adnexa as are not Amenable to Radical Operative Measures. By J. E. JANVRIN, M. D., of New York County . . . . . A Case of Puerperal Eclampsia at the Seventh Month, with a few Thoughts from Practical Experience as to Treatment. By Douglas AYRES, M. D., of Montgomery County . . . . . . . . Tumors of the Orbit. A Detailed Account of Nineteen Cases illus- trating the Paper on the same subject, presented to the New York State Medical Association at its Meeting in 1891. By CHARLEs STEDMAN BULL, M. D., of New York County . . . . . Paraplegia. By CHARLEs W. BRow N, M. D., of Washington, D. C. The Question of Maternal Impressions. By H. S. WILLIAMS, M. D., of New York County . e - - - - i | 18 30 39 60 64 77 86 92 98 . 105 130 . 135 Wi OONTENTS. Clinical Contributions to the Subject of Brain Surgery. By Roswell PARK, M. D., of Erie County . . . . . . . . . . . 146 A Plea for the Early Extirpation of Tumors. By JoHN W. S. GoulEY, M. D., of New York County . . . . . . . . . . . 167 Remarks on a New Method of Intestinal Anastomosis. By BENJAMIN M. RICKETTS, M. D., of Cincinnati, Ohio . . . . . . . . 187 A Report of some Cases of Compound Depressed Fracture of the Skull. By GEORGE D. KAHLo, M. D., of Indiana . . . . . . . 189 The Achievements of American Surgery. By FREDERIC S. DENNIS, M. D., of New York County . . . . . . . . . . . 201 Memoranda, Practical and Suggestive. By H. D. DIDAMA, M. D., of Onondaga County . . . . . . 245 Acute Pleurisy. By FRANK S. PARSONs, M. D., of Northampton, Mass. 256 A Clinico-Pathological Study of Injuries of the Head, with Special Reference to Lesions of the Brain Substance. By CIIARLES PHELPs, M. D., of New York County . . . . . . . . . 274 The Aetiology of Gastric Ulcer. By CHARLEs G. STOCKTON, M. D., of Erie County . . . . . . . . . . . . . . . . The Examination and Commitment of the Public Insane in New York City. By MATTHEw D. FIELD, M. D., of New York County .. 365 Mitral Stenosis in Pregnancy. By ZERA. J. LUSH, M. D., of Wyoming 354 County . . . . . . . . . . . . . . . . . . 379 The Use of Electricity in Midwifery. By OGDEN C. LUDLow, M. D., of New York County . . . . . . . . . . . . . . 388 The Rôle of Microbes in Disease. By N. B. SIZER, M. D., of Kings County . . . . . . . . . . . . . . . . . . 405 Abdominal Hysterectomy for Myoma. By FREDERICK A. BALDWIN, M. D., of New York County . . . . . . . . . . . 421 Extraction of Steel from the Interior of the Eye with the Electro- Magnet. By ALVIN A. HuBBELL, M. D., of Erie County . . 427 The Mental Symptoms of Fatigue. By EDWARD CowLES, M. D., of Somerville, Mass. . . . . . . . . . . . . . . . 441 A Review of some Injuries of the Upper Extremity. By E. M. MooRE, M. D., of Monroe County . . . . . 469 Fractures of the Patella treated by Continuous Extension ; Patients not confined to bed. By Jose.P.H. D. BRYANT, M. D., of New York County . . . . . . . . . . . . . . . . . . 512 Winter Cholera in Poughkeepsie. By JAMES G. PortEous, M. D., of Dutchess County . . . . . . . . . . . . . . . 521 Suggestions Relating to Improvement of Quarantine. By STEPHEN SMITII, M. D., of New York County . . . . . . . . . 531 The Limit of Responsibility in the Insane. By JoHN SIIRADY, M. D., of New York County . . . . . 540 Some Personal Observations and Reſlections upon Alcoholism, the Eſfects of Alcoholic Abuse upon Posterity, and the Treatment of Alcoholism. By H. ERNST ScLIMID, M. D., of Westchester County . . . . . . . . . . . . . . 545 CONTENTS. Wii Climatology in its Relation to Disease. By S. J. MURRAy, M. D., of New York County . . . . . . . . . . . . . . . 559 Pelvic Version. By T. J. McGILLICUDDY, M. D., of New York County 567 Should we treat Fever ? By S. T. ARMSTRONG, M. D., of New York County . . . . . . . . . . . . . . . . . . 576 Brief Comments on the Materia Medica, Pharmacy and Therapeutics of the Year ending November 1, 1892. By E. H. SQUIBB, M. D., of Kings County . . . . . . . . . . . . . . . . 588 Dermic and Hypodermic Therapeutics. By S. F. RogFRs, M. D., of Rensselaer County . . . . . . . . . . . . . . . 676 Some Recent Experience in Renal Surgery. By E. D. FERGUSON, M. D., of Rensselaer County . . 678 The Treatment of Neglected Cases of Rotary Lateral Curvature of the Spine. By REGINALD H. SAYRE, M. D., of New York County 687 Memoir of Abram Du Bois, M. D. By SAMUEL S. PURPLE, M. D., of New York County . . . . . . . . . . . . 716 Memoir of M. Calvin West, M. D. By THOMAS M. FILANDREAU, M.D., of Oneida County . . . . . . . . . . . . . . . 721 Memoir of Myron N. Babcock, M. D. By T. B. REYNoLDs, M. D., of Saratoga County . . . . . . . . . . . . . . . 723 Memoir of Lucien Damainville, M. D. By AUSTIN FLINT, M. D., of New York County . . . . . . . . . . . . . . . 725 Memoir of Nathaniel Clark Husted, M. D. By RICHARD B. CouTANT, M. D., of Westchester County . . . . . . . . . . . 727 Memoir of James Ferguson, M. D. By G. R. MARTINE, M. D., of Warren County . . . . . . . . . . . . . . . . 735 Memoir of William Chace, M. D. By THOMAs D. STRONG, M. D., of Chautauqua County . . . . . . . . . . . . 736 Reports of the District Branches: First District Branch . . . . . . . . . . . . . . 737 Second District Branch . . . . . . . . . . . . . 738 Third District Branch . . . . . . . . . . . . . . 740 Fourth District Branch . . . . . . . . . . . . . 756 Fifth District Branch . . . . . . . . . . . . . . 758 Kings County Medical Association, Annual Report . . . . . . 764 New York County Medical Association, Annual Report . . . . 767 Proceedings, Ninth Annual Meeting . . . . . . . . . . 774 Annual Report of the Council . . . . . . . . . . . . 778 List of Fellows by District and County . . . . . . . . . . 783 Alphabetical List of Fellows . . . . . . . . . . . . . 806 Retired Fellows . . . . . . . . . . . . . . . . . 824 Non-Resident Fellows . . . . . . . . . . . . . . . 824 Honorary Fellows . . . . . . . . . . . . . . . . 824 Corresponding Fellows . . . . . . . . . . . . . . . 824 Deceased Fellows . . . . . . . . . . . . . . . . 826 Index . . . . . . . . . . . . . . . . . . . . . 831 OFFICERS AND COUNCIL FOR 1891–?92. PRESIDENT. JUDSON B. ANDREWS, M. D., Erie County, Fourth District. WICE-PRESIDENTS. FIRST DISTRICT, W. D. GARLOCK, M. D., Herkimer County. SECOND DISTRICT, GEORGE E. McDONALD, M. D., Schenectady County. THIRD DISTRICT, LEROY J. BROOKS, M. D., Chenango County. FIFTH DISTRICT, HENRY WAN HOEVENBERG, M. D., Ulster County. SECRETARY (and Acting Treasurer). E. D. FERGUSON, M. D., Rensselaer County. CHAIRMAN OF THE LIBRARY COMMITTEE. J. W. S. GOULEY, M. D., New York County. MEMBER OF THE COUNCIL AT LARGE. WILLIAM McCOLLOM, M. D., Kings County. ELECTED MEMBERS OF THE COUNCIL. FIRST DISTRICT, E. T. RULISON, M. D., Montgomery County. 6 & g ºf JOHN P. SHARER, M. D., Herkimer County. SECOND DISTRICT, THOMAS WILSON, M. D., Columbia County. 6 & & & J. B. HARVIE, M. D., Rensselaer County. THIRD DISTRICT, H. O. JEWETT, M. D., Cortland County. & 4 & & GEORGE DOUGLAS, M. D., Chenango County. FourTH DISTRICT, S. T. CLARK, M. D., Niagara County. & © & & THOMAS D. STRONG, M. D., Chautauqua County. FIFTH DISTRICT, JOHN G. TRUAX, M. D., New York County. & 6 6 & A. L. CARROLL, M. D., New York County. COMMITTEE OF ARRANGEMENTS FOR 1891–292. JUDSON B. ANDREWS, PRESIDENT. E. D. FERGUSON, SECRETARY. Ea:-officio Members of the Committee. JOHN G. TRUAX, Chairman. CHARLES E. DENISON, Secretary. E. S. F. ARNOLD, GLOWER C. ARNOLD, F. A. BALDWIN, ALFRED L. CARROLL, ELLERY DENISON, A. PALMER DUDLEY, JOHN F. ERDMANN, THOMAS W. P. FLINN, JOHN W. S. GOULEY, GEORGE T. HARRISON, CHARLES A. LEALE, N. W. LEIGHTON, OGDEN C. LUDLOW, JAMES C. MACKENZIE, WILLIAM McCOLLOM, S. B. WYLIE MCLEOD, WALENTINE MOTT, A. D. RUGGLES, JOHN SHRADY, STEPHEN SMITH, E. H. SQUIBB. OFFICERS AND COUNCIL FOR 1892–'93. The Tenth Annual Meeting will be held at the Mott Memorial Library, in New York City, on October 10, 11, 12 and 13, 1893. PRESIDENT. S. B. W. McLEOD, M. D., 247 W. 23d street, New York City. WICE-PRESIDENTS. FIRST DISTRICT, R. N. COOLEY, M. D., Hannibal Centre, Oswego County. SECOND DISTRICT, J. C. HANNAN, M. D., Hoosick Falls, Rensselaer County. THIRD DISTRICT, N. JACOBSON, M. D., Syracuse, Onondago County. FourTH DISTRICT, Z. J. LUSK, M. D., Warsaw, Wyoming County. SECRETARY AND TREASURER. E. D. FERGUSON, M. D., Troy, Rensselaer County. CHAIRMAN OF THE LIBRARY COMMITTEE. J. W. S. GOULEY, M. D., 324 Madison Ave., New York, New York County MEMBER OF THE COUNCIL AT LARGE. JOHN SHRADY, M. D., 149 W. 126th street, New York City. ELECTED MEMBERS OF THE COUNCIL. FIRST DISTRICT, E. T. RULISON, M. D., Amsterdam, Montgomery County ; term expires 1893. & & & & A. P. DODGE, M. D., Oneida Castle, Oneida County; term expires 1894. SEcoRD DISTRICT, THOMAS WILSON, M. D., Claverack, Columbia County; term expires 1893. & & & & J. B. HARVIE, M. D., Troy, Rensselaer County; term expires 1894. THIRD DISTRICT, H. O. JEWETT, M. D., Cortland, Cortland County; term expires 1893. & & & & M. CAVANA, M. D., Oneida, Madison County ; term expires 1894. FourTH DISTRICT, THOMAS D. STRONG, M. D., Westfield, Chautauqua County; term expires 1893. & 4 & & F. H. MOYER, M. D., Moscow, Livingston County; term expires 1894. FIFTH DISTRICT, JOHN D. TRUAX, M. D., 17 E. 127th St., New York, New York County; term expires 1898. “ DISTRICT, A. L. CARROLL, M. D., 80 W. 59th St., New York, New York County; term expires 1894. OFFICERS OF THE BRANCH ASSOCIATIONS FOR 1892. FIRST OR NORTHERN BRANCH. The Ninth Annual Meeting will be held as appointed by the President and Secretary. OFFICERS. PRESIDENT, R. N. COOLEY, M. D., Hannibal Centre, Oswego County. SECRETARY, EZRA GRAVES, M. D., Amsterdam, Montgomery County. EXECUTIVE COMMITTEE. WILLIAM GILLIS, M. D., Fort Covington, Franklin County. ISAAC DE ZOUCHE, M. D., Gloversville, Fulton County. THOMAS McGANN, M. D., Wells; Hamilton County. W. D. GARLOCH, M. D., Little Falls, Herkimer County. J. MORTIMER CRAWE, M. D., Watertown, Jefferson County. ALBERT A. JOSLIN, M. D., Martinsburg, Lewis County. H. M. LEACH, M. D., Glen, Montgomery County. G. ALDER BLUMER, M. D., Utica, Oneida County. E. F. MARSH, M. D., Fulton, Oswego County. GUY REUBEN COOK, M. D., Louisville, St. Lawrence County. SECOND OR EASTERN BRANCH. The Ninth Annual Meeting will be held at Saratoga Springs, Saratoga County, on the fourth Thursday in June, 1893. OFFICERs. PRESIDENT, J. C. HANNAN, M. D., Hoosick Falls, Rensselaer County. SECRETARY, JOSEPH E. BAYNES, M. D., Troy, Rensselaer County. ExECUTIVE COMMITTEE. W. B. SABIN, M. D., West Troy, Albany County. E. M. LYON, M. D., Plattsburgh, Clinton County. T. F. WOODWORTH, M. D., Kinderhook, Columbia County. OFFICERS OF THIE, BRAWCH ASSOCIATIONS. 5 LYMAN BARTON, M. D., Willsborough, Essex County. ROBERT SELDEN, M. D., Catskill, Greene County. J. P. MARSH, M. D., Troy, Rensselaer County. I. G. JOHNSON, M. D., Greenfield Centre, Saratoga County. H. C. WAN ZANDT, M. D., Schenectady, Schenectady County. WILLIAM HAGADORN, M. D., Gilboa, Schoharie County. G. R. MARTINE, M. D., Glens Falls, Warren County. A. J. LONG, M. D., Whitehall, Washington County. THIRD OR CENTRAL BRANCH. The Ninth Annual Meeting will be held at Elmira, Chemung County, on the third Thursday in June, 1893. OFFICERS. PRESIDENT, N. JACOBSON, M. D., Syracuse, Onondaga County. SECRETARY, C. L. SQUIRE, M. D., Elmira, Chemung County. EXECUTIVE COMMITTEE. H. C. ROGERS, M. D., Binghamton, Broome County. W. R. LAIRD, M. D., Auburn, Cayuga County. F. W. ROSS, M. D., Elmira, Chemung County. H. C. LYMAN, M. D., Sherburne, Chenango County. F. W. HIGGINS, M. D., Cortland, Cortland County. W. B. MORROW, M. D., Walton, Delaware County. M. CAVANA, M. D., Oneida, Madison County. F. O. DONOHUE, M. D., Syracuse, Onondaga County. JOSHUA. J. SWEET, Unadilla, Otsego County. B. T. SMELZ.E.R., M. D., Havana, Schuyler County. ELIAS LESTER, M. D., Seneca Falls, Seneca County. W. L. AYER, M. D., Owego, Tioga County. WILLIAM FITCH, M. D., Dryden, Tompkins County. FOURTH OR WESTERN BRANCH. The Ninth Annual Meeting will be held at Rochester, Monroe County, on the Second Tuesday in May, 1893. OFFICERS. PRESIDENT, Z. J. LUSK, M. D., Warsaw, Wyoming County. SECRETARY, WM. H. THORNTON, M. D., 570 Niagara St., Buffalo, Erie County. 6 NEW YORK STATE MEDICAL ASSOCIATION. EXECUTIVE COMMITTEE. J. A. STEPHENSON, M. D., Scio, Alleghany County. S. J. MUDGE, M. D., Olean, Cattaraugus County. NELSON G. RICHMOND, M.D., Fredonia, Chautauqua County. C. FREDERICK, M. D., Buffalo, Erie County. W. TOWNSEND, M. D., Bergen, Genesee County. H. MOYER, M. D., Moscow, Livingston County. M. MOORE, M. D., Rochester, Monroe County. W. Q. HUGGINS, M. D., Lockport, Niagara County. F. D. WANDERHOOF, M. D., Phelps, Ontario County. JOHN H. TAYLOR, M. D., Holley Orleans County. JEREMIAH DUNN, M. D., Bath, Steuben County. DARWIN COLVIN, M. D., Clyde, Wayne County. A. G. ELLINWOOD, M. D., Attica, Wyoming County. WILLIAM OLIVER, M. D., Penn Yan, Yates County. C. M. F. R. FIFTH OF SOUTHERN BRANCH. The Ninth Annual Meeting will be held in Brooklyn, Kings County, on the fourth Tuesday in May, 1893. OFFICERS. PRESIDENT, S. B. W. McLEOD, M. D., 247 W. 23d street, New York City. SECRETARY, E. H. SQUIBB, M. D., P. O. Box 760, Brooklyn, Kings County. ExECUTIVE COMMITTEE. D. LE ROY, M. D., Pleasant Valley, Dutchess County. . RUSHMORE, M. D., Brooklyn, Kings County. H. MANLEY, M. D., New York, New York County. C. CONNER, M. D., Middletown, Orange County. W. MURDOCK, M. D., Cold Spring, Putnam County. L D i . D . G. RAWE, M. D., Hicksville, Queens County. . U. JOHNSTON, M. D., New Brighton, Richmond County. ILLIAM GOWAN, M. D., Stony Point, Rockland County. . D. WOODEND, M. D., Huntington, Suffolk County. . H. DE KAY, M. D., Wurtsborough, Sullivan County. . WAN HOEVENBERG, M. D., Kingston, Ulster County. H. E. SCHMID, M. D., Tarrytown, Westchester County. § H LIST OF PRESIDENTS AND WICE-PRESIDENTS FROM THE FOUNDING OF THE ASSOCIATION. 1884. PRESIDENT. HENRY D. DIDAMA, M. D., Onondaga County, Third District. WICE-PRESIDENTS. FIRST DISTRICT, J. MORTIMER CRAWE, M. D., Jefferson County. SECOND DISTRICT, TABOR B. REYNOLDS, M. D., Saratoga County. FourTH DISTRICT, B. L. HOVEY, M. D., Monroe County. FIFTH DISTRICT, *NATH'L C. HUSTED, M. D., Westchester County. *-*-m-º. 1885. PRESIDENT. *JOHN P. GRAY, M. D., Oneida County, First District. WICE-PRESIDENTS, SECOND DISTRICT, WILLIAM H. ROBB, M. D., Montgomery County. THIRD DISTRICT, JOHN G. ORTON, M. D., Broome County. FourTH DISTRICT, JOSEPH C. GREENE, M. D., Erie County. FIFTH DISTRICT, * JOSEPH C. HUTCHINSON, M. D., Kings County. 1886. PRESIDENT. E. M. MOORE, M. D., Monroe County, Fourth District. WICE-PRESIDENTS. FIRST DISTRICT, WILLIAM GILLIS, M. D., Franklin County. SEcoRD DISTRICT, H. C. WAN ZANDT, M. D., Schenectady County. THIRD DISTRICT, * FREDERICK HYDE, M. D., Cortland County. FIFTH DISTRICT, J. G. PORTEOUS, M.D., Dutchess County. 1887. PRESIDENT, *ISAAC E. TAYLOR, M. D., New York County, Fifth District. * Deceased. 8 MEW YORK STATE MEDIOAL ASSOCIATION. WICID-PRESIDENTS. FIRST DISTRICT, JOHN P. SHARER, M. D., Herkimer County. SIRCOND DISTRICT, L. C. DODGE, M. D., Clinton County. THIRD DISTRICT, * GEORGE W. AVERY, M. D., Chenango County FourTH DISTRICT, DARWIN COLVIN, M. D., Wayne County. 1888. PIRICSIDENT. JOHN CRONYN, M. D., Erie County, Fourth District. WICE-PRICSIDENTS. FIRST DISTRIOT, BYRON DE WITT, M. D., Oswego County. SIBoonD DISTRICT, ROBERT SELDEN, M. D., Greene County. THIRD DISTRIOT, CHARLES W. BROWN, M. D., Chemung County. FIFTH DISTRIOT, EDWIN BARNES, M. D., Dutchess County. 1889. PRESIDIENT. WILLIAM T. LUSK, M. D., New York County, Fifth District. WICE-PRESIDENTS. FIRST DISTRICT, S. H. FRENCH, M. D., Montgomery County. SIRCOND DISTRIOT, R. C. McEWEN, M. D., Saratoga County. THIRD DISTRICT, ELIAS LESTER, M. D., Seneca County. FourTH DISTRIOT, THOMAS D. STRONG, M. D., Chautauqua County. 1890. PRIESIDIENT. JOHN G. ORTON, M. D., Broome County, Third District. WICE-PRIESIDIENTS. FIRST DISTRIOT, DOUGLAS AYRES, M. D., Montgomery County. SEcond DISTRIOT, M. H. BURTON, M. D., Rensselaer County. FourTH DISTRIOT, E. M. MOORE, J.R., M. D., Monroe County. FIFTII DISTRIOT, WILLIAM MoCOLLOM (Wice WILLIAM B. EAGER, (deceased), Kings County. * 1891. PRIESIDENT, STEPHEN SMITH, M.D., New York County, Fifth District. + * Deceased, PRESIDENTS AND WICE-PRESIDENTS. 9 WICE-PRESIDENTS. FIRST DISTRICT, DOUGLAS AYRES, M. D., Montgomery County. SEoonD DISTRICT, A. T. WAN WIRANKEN, M. D., Albany County. THIRD DISTRICT, J. D. TRIPP, M. D., Cayuga County. FourtTII DISTRICT, ROBERT J. MENZIE, M. D., Livingston County. tºmºsº-ºº: 1892. PRESIDENT. JUDSON B. ANDREWS, M. D., Erie County. WICE-PRESIDENTS. FIRST DISTRICT, W. D. GARLOCK, M. D., Herkimer County. SIEconD DISTRICT, GEORGE E. McDONALD, M. D., Schenectady County. THIRD DISTRICT, LEROY J. BROOKS, M. D., Chenango County. FIFTH DISTRICT, HENRY WAN HOEVENIBERG, M. D., Ulster County. LIST OF FELLOWS REGISTERED AT THE NINTH ANNUAL MEETING IN NEW YORK CITY, Held November 15, 16, and 17, 1892. FIRST DISTRIOT. HERKIMER COUNTY. Garlock, W. D., Little Falls. MONTGOMERY COUNTY. Ayres, Douglas, Fort Plain. ONEIDA COUNTY. Dodge, A. P., Oneida Castle. OSWEGO COUNTY. DeWitt, Byron, Oswego. rºm- SECOND DISTRICT. CLINTON COUNTY. Dodge, L. C., Rouses Point. Lyon, E. M., Plattsburgh. Holcomb, Oscar A., Plattsburgh. COLUMBIA. COUNTY. Wilson, Thomas, Claverack. GREENE COUNTY. Selden, O. G., Catskill. Selden, Robert, Catskill. IRENSSELAER COUNTY. Bontecou, R. B., Troy. Harvie, J. B., Troy. Burbeck, Charles H., Troy. Lyon, George E., Troy Cahill, John T., Hoosick Falls. Phelan, M. F., Troy. Ferguson, E. D., Troy. Rogers, S. F., Troy. Hannan, J. C., Hoosick Falls. WARREN COUNTY. Martin, G. R., Glens Falls. THIRD DISTRICT, BROOME COUNTY. Fitzgerald, John F., Binghamton. FELLO WS AT THE WINTH "AWWUAJC MEETING. 11 CAYUGA COUNTY. Tripp, J. D., Auburn. CHEMUNG COUNTY. Brown, Chas. W., Washington, D. C. Ross, Frank W., Elmira. Drake, Emory G., Elmira. CHENANGO COUNTY. Brooks, Leroy J., Norwich. Douglas, George, Oxford. CORTLAND COUNTY. Higgins, F. W., Cortland. Jewett, H. O., Cortland. DELAVARE COUNTY. Morrow, W. B., Walton. MADISON COUNTY. Cavana, Martin, Oneida. Huntley, James F., Oneida. ONONIDAGA COUNTY. Brown, U. H., Syracuse. Jacobson, Nathan, Syracuse. Didama, H. D., Syracuse. OTSEGO COUNTY. Leaning, J. K., Cooperstown. SENECA COUNTY. Seaman, Frank G., Seneca Falls. TIOGA COUNTY. Ayer, W. L., Owego. Cady, George M., Nichols. FOURTH DISTRICT. CATTAR AUGUS COUNTY. Mudge, S. J., Olean. CHAUTAUQUA COUNTY. Strong, Thomas D., Westfield. Ames, Edward, Kalamazoo, Mich. RRUE COUNTY. Andrews, J. B., Buffalo. Park, Roswell, Buffalo. Congdon, Charles E., Buffalo. Putnam, James W., Buffalo. Cronyn, John, Buffalo. Stockton, Charles G., Buffalo. Hubbell, Alvin A., Buffalo. Thornton, W. H., Buffalo. Ingraham, Henry D., Buffalo. Tremaine, W. S., Buffalo. GENESEE COUNTY. Jackson, A. P., Oakfield. LIVINGSTON COUNTY. Moyer, F. H., Moscow, 12 ME W YORK STATE MEDICAL ASSOCIATION. MONIROE COUNTY. Goler, G. W., Rochester. Hovey, B. L., Rochester. WAYNE Horton, D. B., Red Creek. Moore, E. M., Rochester. COUNTY. WYOMING COUNTY. Ellinwood, A. G., Attica. Lusk, Z. J., Warsaw. FIFTH DISTRICT. DUTCHESS COUNTY. Barnes, Edwin, Pleasant Plains. LeRoy, Irving D., Pleasant Valley. Porteous, J. G., Poughkeepsie. Pultz, M. T., Stanfordville. VanWyck, R. C., Hopewell Junction. RINGS COUNTY. Baker, Frank R., Brooklyn, Baker, George W., Brooklyn. Biggam, W. H., Brooklyn. Creamer, Joseph, Brooklyn. Feely, James F., Brooklyn. Leighton, N. W., Brooklyn. McCollom, William, Brooklyn. Minard, E. J. C., Brooklyn. North, N. L., Brooklyn. Paine, Arthur R., Brooklyn. Russell, William G., Brooklyn. Sizer, Nelson B., Brooklyn. Squibb, E. H., Brooklyn. Squibb, E. R., Brooklyn. Steinke, H. C. O., Brooklyn. Sullivan, J. D., Brooklyn. Wieber, George, Brooklyn. Wycoff, R. M., Brooklyn. NEW YORK COUNTY. Armstrong, S. T., New York. Arnold, E. S. F., New York. Arnold, Glover C., New York. Baldwin, F. A., New York. Bryant, Joseph D., New York. Bull, Charles Stedman, New York. Carroll, A. L., New York. Chrystie, T. M. L., New York. Curry, Walker, New York. Davis, J. Griffith, New York. Delphey, Eden W., New York. Denison, Charles E., New York. Denison, Ellery, New York. Dennis, Frederic S., New York. De Quesada, Gregorio J., New York. Dudley, A. Palmer, New York. Eastman, Robert W., New York. Eliot, Ellsworth, New York. Erdmann, John F., New York. Flinn, Thomas W. P., New York. Flint, W. H., New York. Furman, Guido, New York. Gouley, J. W. S., New York. Harrison, Geo. Tucker, New York. Holmes, Martha C., New York. Hubbard, Samuel T., New York. Janvrin, J. E., New York. Ring, Ferdinand, New York. Leale, Charles, New York. Ludlow, Ogden C., New York. Lukens, Anna, New York. Lynch, P. J., New York. Mackenzie, James C., New York. Manley, Thomas H., New York. McLeod, Johnston, New York. McLeod, S. B. W., New York. FELLO WS AT THE WINTET ANNUAL MEETING. 13 McLochlin, J. A., New York. Shrady, John, New York. Milliken, S. E., New York. Shrady, John E., New York. Mott, Valentine, New York. Silver, Henry M., New York. Murphy, John, New York. Smith, J. Lewis, New York. Murray, S.J., New York. Smith, Stephen, New York. O’Brien, M. C., New York. Thompson, Van Beverhout, New Ochs, B. F., New York. York. Phelps, Charles, New York. Truax, J. G., New York. Porter, P. Brynberg, New York. Wallach, J. G., New York. Purple, Samuel S., New York. Weeks, John E., New York. Rau, Leonard S., New York. Weston, Albert T., New York. Ricketts, B. M., Cincinnati, Ohio. White, J. Blake, New York. Ruggles, A. D., New York. White, William T., New York. Sayre, Reginald H., New York. Wiggin, F. H., New York. Shea, Dennis L., New York. Williams, H. Smith, New York. ORANGE COUNTY. Conner, M. C. Middletown. Wanderweer, J. R., Monroe. ROCKLAND COUNTY. Govan, William, Stony Point. sullivan county. Crocker, Edwin, Narrowsburg. Piper, C. W., Wurtsborough. ULSTER COUNTY. Wan Hoevenberg, H., Kingston. WESTCHESTER COUNTY. Acker, T. J., Croton-on-Hudson. Schmid, H. Ernst, White Plains. NON_RESIDENT FELLOWS. Murdoch, James Bissett, Pittsburg, Pa. SUMMARY BY DISTRICTs OF FELLOWS IN ATTENDANCE. First District, . e g © tº & * º 4 Second District, . e {} ſº e º e & 16 Third District, . te & . . e g * 19 Fourth District, . e e • s • o e g 21 Fifth District, & re e & e º e * 96 Non-Resident, . t tº e & ſº * s 1 Total, . & º tº gº g fo & gº 157 DELEGATES FROM OTHER MEDICAL ORGAN ISATIONS AND INVITED ATTENDANCE. CONNECTICUT. CHARLES D. ALTON, M. D., HARTFoRD, INDIANA. GEORGE D. KAHLO, M. D., INDIANAPOLIS, MAINE. B. B. FOSTER, M. D., Port LAND, MARYLAND. W. H. McCORMICK, M. D., CUMBERLAND, MASSACHUSETTS, EDWARD COWLES, M. D., SOMERVILLE, FRANK S. PARSONS, M. D., NorthAMPTON, MINNESOTA. J. W. SCOTT, M. D., ST. CHARLEs, RHODE ISLAND. CHARLES O'LEARY, PROVIDENCE, GUESTS IN Delegate. Invited Guest. Delegate. Invited Guest. Invited Guest. Invited Guest. Invited Guest. Delegate. ADDRESS OF WELCOME AND REPORT OF THE COMMITTEE OF APRANGEMENTS. By J. G. TRUAx, M. D., of New York County, Chairman of the Committee. GENTLEMEN-Again it becomes my duty, as chairman of the Committee of Arrangements, to welcome you to this city, and to this, the ninth annual meeting of the New York State Medical Association. That it is a pleasure to us to see you coming, year after year, to these meetings, needs not verbal expression that it may be understood. The efforts of your Committee of Arrangements to pro- vide something which will in a measure compensate you for loss of time, and the trouble necessarily connected with a journey to this city, is proof sufficient that your presence is appreciated. In this connection I will take the liberty of informing you, that it is not as easy a task as it might at first ap- pear to be, to secure the matter within our own ranks for a three-days’ session. To some of you, more than one appeal is required be- fore gaining your consent to take part in these exercises, I know that this seeming unwillingness to write papers for our annual meetings does not arise from want of in- terest in our Association or its work, but rather from fear that what might be offered would not equal in merit that which further efforts on the part of your Committee of Arrangements could secure. However becoming this modesty may be, one can readily realise that it does not lessen the labor of those whose duty it is to secure the material for a meeting. The existence of such a con- dition of affairs might be accounted for on the ground, that for no kind of work is the physician overpaid, or paid too quickly; and in this, the hardest field of labor, 16 NEW YORK STATE MEDICAL ASSOCIATION. his reward comes late, if ever. Not for a moment would I have you think that the chairman of your Committee of Arrangements has ever become discouraged. So much willingness on the part of many Fellows to perform any labor imposed upon them by your chairman, has pre- vented any such feeling from taking possession of him. Our Association is growing all the time, yet a little more effort on the part of each Fellow, to secure new members, would add greatly to our numbers, as well as to the in- fluence we exert upon the profession at large, and upon the public. Your chairman is particularly anxious that the growth of the Association may be very rapid during the year to come. He is perfectly satisfied, judging from the success of his own efforts in this direction in the past, that enough new desirable men can be secured during the next year, to bring Our membership to num- ber a thousand. Will you encourage us by doing what you can in this direction ? There are to be two addresses—one by the president, Judson B. Andrews, M. D., of Erie County ; and the other by Frederic L. Dennis, M. D., of New York County. The discussions, which have been a feature of so much importance in the programmes of the past, have been omitted this year. Altogether, there are forty-six subjects to be con- sidered by forty-four speakers. These contributions come from the five districts of the State, and from sister States, in the following proportions: The First District, 2 Second ‘‘ 2 Third ( 6 3 FOUlrth. “ 8 Fifth % ( e 27 State of Massachusetts, 2 & C Indiana, 1 ( & Ohio, 1 District of Columbia, 1 ADDRESS OF WELCOME. 17 In the five districts, Fellows of the Association from eleven counties contribute essays in the following pro- portions: First District, Montgomery County, 2 Second ‘‘ Rensselaer 6 ( 2 Third ‘‘ Cortland ( & 1 “ “ Onondaga ( & 2 Fourth ‘‘ Erie Ç G 6 { % & 4 Wayne { % 1. { % ( & Monroe { % 1 Fifth { % New York & 6 23 ( & { % King|S & C 2 & 4 { % Dutchess & 6 1 { % { % Westchester { % 1 If no time be lost, and the discussions are confined to the ten minutes allowed to each person, your committee is of the opinion that two evening Sessions, in addition to the regular morning and afternoon sessions, will be sufficient. The morning sessions will be opened at nine o'clock, the afternoon sessions at One, and the evening Sessions ath alf-past seven. One paper has been re- ceived since the distribution of the official programme; it is by B. Merrill Ricketts, M. D., of Cincinnati, Ohio. PRESIDENT'S ANNUAL ADDRESS. *=====e THE ALIENIST AND THE GENERAL PRACTI— TIONER. . BY JUDSON B. ANDREws, M. D., of Erie County. Movember 15, 1892. The student of to-day appreciates as never before the Constant widening of the field of medical knowledge, and realises the impossibility of becoming equally proficient in all the varied departments which have been developed during recent years. He is also forced by the logic of events to acknowledge that much of the real progress in medicine is due to the zeal and patient research of the skilled specialist. The division of labor implied by the term, the outcome of our advancing civilisation, is com-. mon to all the arts and sciences, and is true evolution in medicine. It has wrought such changes that the general Dractitioner, who formerly decried the specialist, now joins hands with him in the effort to benefit humanity. Experience has made them friends, and the family physi- cian Willingly summons him to his aid without distrust, Or the fear that he may lose the confidence of his patient. To properly sustain his position the specialist must be thoroughly trained, first, as a physician, and secondly, in the branch in which he assumes to be skilled; otherwise his knowledge is superficial and inexact, and his view is narrowed down to his personal horizon, as he sees only through his own myopic glasses. Breadth of vision comes only from breadth of knowledge. Specialism Suffers more from pretenders, who without sufficient education in the general science of medicine, and with but a Smattering of special training, assume to possess peculiar skill, than from the opposition or distrust of TEIE PRESIDENT'S ANNUAL ADDRESS, 19 the general physician. Like all other frauds they are in time discovered and relegated to their true position in the profession. The opportunities for acquirement are too many, and the demands of the public are too great, to allow ignorance to flourish, or to excuse its existence, least of all in the man who makes pretense of Special medical skill. As all specialties are but an outgrowth from the general field of medicine, no one can successfully divorce them, or even bring them into conflict. This inter- dependence places an obligation upon the general practi. tioner to acquire a degree of knowledge of the various departments of medicine. While, for instance, he may not be able to perform the most delicate, or the major operations in surgery, he must at least have such a familiar acquaintance with the subject, as will enable him to seek the aid of the surgeon when the need of his patient demands it. It is only during the past few years, however, that it has been possible for him to attain such knowledge; but now the longer curriculum and the increased number of instructors in our medical schools, place it in the power of the student to gain an acquaintance with the various departments, as he has the advantage of both didactic and clinical illustration in the recognised special courses. There are, however, some specialties which, till within a recent period, have been separated and kept to a large degree distinct from the general practice of medicine, and among them is that of the alienist. The reason for this state of things is to be found in the peculiar nature of the disease, which made it impossible to care for the insane at their homes, and rendered it necessary to Commit them to institutions erected for their care and treatment. As the physician was thus compelled to intrust his patient to those in charge of asylums, he lost interest in the conduct of the case, and also the incen- tive to fit himself for taking charge of this class of patients. It was enough for him to recognise the 20 NEW YORK STATE MEDICAL ASSOCIATION. existence of mental disturbance, and then to adopt measures to relieve himself of the responsibility in- Volved in the treatment. When sent to an asylum, the patient passed completely from the control of the family physician, who, either because of distance, or lack of opportunity, rarely or never visited his patient, or kept himself informed of his progress. Another fact which in part accounts for the separation of the alienist from the general practitioner, is that no instruction was given in the medical schools upon the subject of insanity. It was not recognised as a physical disease, but was believed to be induced by some occult power, little understood, and still less investigated. The metaphysi- cal idea of insanity, the remnant of the old view that it was the result of divine displeasure for sins committed, had a perverting influence, not only in the lay mind, but even in the medical profession. Those of us who graduated from medical schools prior to twenty years ago, and I might make the number of years even less, received little, if any instruction on the subject of insanity, and many of us never heard the disease men- tioned by our instructors, or found it treated of in any intelligent way in the text-books on practice. It was inevitable that those who were in charge of asylums should be a class by themselves, and looked upon as possessing a certain knowledge and skill which was denied the rest of the profession, and that under all these conditions, the study of the mind, as it was popu- larly called, should be a sealed book to the general practitioner. Another reason why the subject of insanity did not claim general attention in the profession, was the fact that the laws of commitment to asylums, either did not demand certificates of lunacy to be made out, or if they did require them, they only registered the opinion of the physician, and not the reasons on which that opinion was based. This rendered unnecessary any study of the disease, and was simply giving a bonus to ignorance. Nearly all experience and knowledge which THE PRESIDENT'S ANW UAE, ADDRESS. 21 was of any real value, was centred in the few superin- tendents of asylums which existed in the State, and these were numbered, almost if not quite, by the fingers of one hand. There were a few exceptions to this rule, for the profession has always counted among its num- bers some men who, like our venerable friends, Pro- fessors Moore and Cronyn, were equipped in this, as in other specialties. According to the report of the Illinois State Board of Health for 1891, there are, in the United States and Canada, one hundred and forty-eight medical Schools and colleges, and in fifty-three of them, lectures are given on the subject of insanity, and in seventy-five of them, in diseases of the nervous system. This is cer- tainly an indication of progress in medicine during the past twenty years. This progress is not confined to this continent, and is even more marked among other nation- alities. In Great Britain, the medical council has added to the general course the study of insanity, and has made examinations and clinical instruction an obligatory part of the five years' course of medical education. The vari- ous institutions for the care of the insane which are located in proximity to medical schools, are Opening their doors for clinical instruction, and the positions of teachers are being largely filled by the superintendents of asylums. In this country, attendance upon lectures on insanity has been made compulsory in but few of the schools. Others will no doubt soon be added to the number, and all should demand at least a passing knowledge of the Subject from each of their graduates. The instruction should be of a practical character. Lectures given by those who have but a theoretical acquaintance with the Subject, derived from reading and study, without ex- perience in the treatment of the insane, can, in the nature of things, be of little practical utility to the student. Years ago the importance of instruction in insanity at- tracted the attention of some of the ablest men in the 22 NEW YORK STATE MEDICAL ASSOCIATION. specialty. To Dr. Gray, of Utica, one of the early presidents of this association, the profession owes a debt of gratitude for his persistent and self-sacrificing labors in behalf of instruction in this branch. His lectures, among the first delivered in this city, were marvels of that clearness and precision which come only from inti- mate knowledge of the subject, and from personal care of the insane. The value of this knowledge to the general practitioner can hardly be overestimated. He is called upon to make the diagnosis, and to express his opinion as to the needs of his patient who is suffering from mental disturbance. Without instruction he is helpless, and proves but a broken reed to the family, when he should be the firm support. Many cases of insanity are kept at home dur- ing the early period of the disease, when the chances of recovery, under proper care and treatment, are hopeful, from ignorance of the real condition. Too often, cases of melancholia are allowed to drift on to death by Sui- cide, from the lack of appreciation of the danger which threatens. It is painful to hear of a patient sent from home to a distant point, under the delusive hope that change of climate or of surroundings will effect a cure, when from his depression and self-absorption, the indi- vidual is unable to appreciate his condition, or cannot be roused from the all-pervading mental gloom which enshrouds him, and when he demands kind, intelligent nursing, and the closest attention to his condition in order to effect the re-establishment of his normal, mental and bodily health. With obligatory instruction in mental diseases, made a part of the curriculum of study, there would be a more correct appreciation of mental states, and an earlier diag- nosis of the existence of disease ; a more intelligent treatment would be adopted, and as a consequence, the statistics of recovery would be more favorable. There would also be fewer medico-legal cases, and a marked diminution of will contests. Patients far advanced in THE PRESIDENT'S ANNUAL ADDRESS. 23 dementia, or suffering from general paralysis of the in- sane, would not be received into hospitals and the friends given a favorable prognosis, and we would hear much less from physicians and from the friends of patients about the diagnosis of “brain softening” in simple, and often curable cases of insanity. The law now makes it the duty of the physician to fill out certificates of lunacy, and in them to record the reasons for his belief in the insanity of the patient. They should, and with a proper knowledge of the Sub- ject on the part of the physician, would contain such valid reasons on which the belief in lunacy was predicated, as would carry conviction, and even satisfy a jury of their sufficiency. The simple statement—I quote from a cer- tificate—that “he presents the usual symptoms of chronic dementia,” would not shield a practitioner from a suit for false imprisonment upon insufficient grounds for his commitment to an asylum, unless there actually existed more cogent reasons for such a step ; and if they do exist, why should not they be distinctly stated in the certi- ficate % Fortunately the facts of the case generally sus- tain the physician more strongly even than his statement in the certificate. The fundamental fact which the cer- tificate should express is too often ignored, viz.: the change in the individual, in his mode of feeling, think- ing, or acting, based upon the physical changes induced by disease ; or, stating it in correct order, first the phys- ical changes, and then the departure in mental states. Certificates thus formulated will stand the required test, and will meet the demands of the State authorities who Supervise the papers of commitment. I do not wish or intend to arraign the physician, but simply to point out the direction in which improvement can be made, and which will naturally follow the better facilities for instruction enjoyed by the younger men in the profession. Although the family physician so generally recognises the presence of insanity when it occurs in his patients, 24 NETW YORK STATE MEDICAL ASSOCIATION. and also the necessity of treatment, I can but think he Sometimes neglects to enforce preventive measures in cases where his influence might avert the threatened danger. It is during early life and the period of develop- ment that the greatest care should be exercised, and the physician should interpose his authority for the good of his patient. The duty of the physician, as well as the parent, during these periods, is well stated by Dr. Clouston in his recent work on “The Neuroses of Development.” He teaches, as all alienists and neurol- ogists do, the doctrine of nutrition to its fullest extent. His advice is summed up in this sentence: “Fatness, Self-control, orderliness, are the three most important qualities to aim at. Build up the bone, and fat, and muscle, especially the fat, by any means known to us, during the period of growth and development.” There is nothing so conducive to nerve equilibrium as a fully nourished body, for it gives repose and freedom from irritability. Stated in a general way, it is the poorly nourished and the ill-developed who suffer from the neuroses which are so often the precursors of insanity. Give to children fresh air; withhold from them nitrogenous and stimulating foods during the period of development of the reproductive function; repress the imaginative faculties, and develop the lower centres in all of the mentally active and precocious; let the education and growth of the body take precedence, and that of the mind will naturally and healthfully follow. Finally, promote order, method, and system. They are most important elements of mental health, as well as of success, and are especially lacking in the weakly neurotic." Another direction in which the family physician can exercise control in the way of prevention, is in opposing ill-advised and ill-assorted marriages among the neuro- tic, the epileptic, and insane. The extent to which the uneducated indulge in these unions, and their indiffer- 1 Clouston. TEIE PRESIDENT'S ANNUAL ADDRESS. 25 ence to the danger thus incurred, are sufficient to arrest the thoughtful attention of those familiar with the facts. Within a few days there was admitted to the hospital under our charge, a patient who had been epileptic for years, and yet had married only three weeks before his admission. The result was a series of epileptic attacks, accompained by maniacal violence and homicidal ten- dencies. His friends urged the step in the belief that marriage would cure the fits. It is not an uncommon occurrence for the friends and relatives of a man whose sexual powers have been weakened by secret habits, to seek an alliance with some unsuspecting woman, in the hope of effecting a cure ; and, on the other hand, it is not rare for the friends of a hysterical, enfeebled woman, whose reproductive func- tions have been blighted by some of the various disorders common to the sex, or who has suffered from insanity, to scheme to arrange a marriage, which will relieve them from the burden of caring for her. What must be the baneful results of such marriages to the individuals, to their posterity, if they have any, and to the community which is generally called upon to support, not only the progeny, but often the parents Then there is the large class of defectives, the higher grade imbeciles, who are allowed to form marriages without let or hindrance. I do not doubt that every practitioner of years, who may read these remarks, can recall instances of one or of all of these very cases. We cannot lay the blame at the door of the medical man, but it may lead us to inquire of ourselves whether we have done our whole duty in educating the people and informing them of the danger incurred, or in arousing a public sentiment against the COnSummation of such wicked frauds. It is in these two directions of caring for the young during the developmental period, and in preventing union between the defective classes, that much can be accomplished in the way of preventing mental disorders. Add to this the care of the general health in other cases 26 NEW YORK STATE MEDICAL ASSOCIATION, not included in the above, and the medical man has exhausted his resources in the way of prevention. It is often easy, after the actual occurrence of an attack of insanity, to look back over the history of the case, and note the causative influences which have led up to the final catastrophe, and Sometimes to see how this might have been avoided if entire control of the patient could have been exercised. This is, however, impossible in most cases. The physician is overpowered by the environment of the individual. The absolute necessity for hard, grinding toil, even to the breaking down of health, in the effort to support a family, and the fret and worry of life, are stronger than all the advice and en- treaty of the physician, who perhaps foresees the end from the beginning. Relief is only obtained when, from the open outbreak of the mental disorder, the strong hand of the law steps in and consigns the unfortunate individual to the hospital provided by the kindly charity of the public. Such an array of facts leads the alienist to sympathise most heartily with the general practitioner in his difficulties in the treatment of insanity, and cements more firmly the bond of union between them. It is to the greater confidence of the general profes- sion in the asylums of the State, that their growth and success is in a great measure due. The last census report attributes the increase of patients under care in asylums, to a greater willingness to place these unfortu- nates in such places, as a consequence of increased con- fidence in the conduct of hospitals for the insane. The basis of this confidence is found in the improvements in these institutions, due to the promotion of the hospital idea in the treatment of the insane, to the greater indi- vidualisation rendered possible by the increase of medical Officers, to the change made in appointments after Civil Service examinations of both officers and attendants, to the wonderful improvement in the service brought about by the introduction of training schools into hospitals for the insane, and to the supervision of a legally constituted THE PRESIDENT'S ANNUAL ADDRESS. 27 Lunacy Commission. These are the steps of progress which have placed the hospitals of our State in the front rank of like charitable institutions of the world, and in all of these measures the State of New York took the initiative. If to these we add the restriction of mechan- ical restraint, the employment of patients, the improve- ments in construction resulting from the introduction of hospital and infirmary wards, and of nurses’ homes, the greater attention to moral treatment by a resort to varied means of entertainment, and by the use of physical culture, and lastly, and most important, the general employment of night nursing, we present a con- densed retrospect of the improvement in our hospitals for the insane, which rightly enlists the confidence of the profession and of the community. This confidence is shown not only in the large number of patients com- mitted under certificates by general practitioners, but by the interest manifested by them in the conduct of the various hospitals of the State. The very progress made by these hospitals has been rendered possible only by the support of the profession. The former barriers having been thus broken down, the alienist is brought into closer relations with his professional brethren. As indicating the tendency of the times, I quote a cir- cular recently issued to the Managers of State Hospitals by the State Commission in Lunacy. ALBANY, Nov. 10, 1892. THE CLINICAL TEACHING OF INSANITY IN PUBLIC HOSBITALS FOR THE INSANE. To the Managers of State Hospitals: The Association of Medical Superintendents of American Institutions for the Insane, at its annual meeting, held at Toronto, Canada, in 1871, adopted the following resolutions: Resolved, That, in view of the frequency of mental disorders among all classes and descriptions of people, and in recognition of the fact that the first care of nearly all these cases necessarily devolves upon physicians engaged in general practice, and this at a period when sound views of the disease and judicious modes of treatment are specially important, it is the unanimous opinion of this Association, that in every school conferring medical degrees, there should be delivered, by competent professors, a com- 28 NEW YORK STATE MEDICAL ASSOCIATION. plete course of lectures on insanity and on medical jurisprudence, as con- nected with disorders of the mind. Resolved, That these lectures should be delivered before all the students attending these schools, and that no one should be allowed to graduate without as thorough an examination on these subjects as on the other branches taught in the schools. Resolved, That in connection with these lectures, whenever practicable, there should be clinical instruction, so arranged that, while giving the student practical illustrations of the different forms of insanity and the effects of treatment, it should in no way be detrimental to the patients. Since the adoption of these resolutions public sentiment has become more pronounced in favor of carrying out their purpose and spirit. The fact that insanity is a far more frequent and serious disease than many others, the nature and symptoms of which medical students are re- quired to possess a practical knowledge before being permitted to gradu- ate, renders it of the highest importance to the general public that a wider diffusion of correct knowledge of the disease and of its proper manage- ment, particularly in its early and most curable stage, should obtain among the medical profession. This is especially important, in view of the fact that, in a large majority of cases, the presence of the disease, in the first instance, must necessarily be determined by the general practitioner— usually the family physician. Citizens of the State, of all classes, could not fail of being benefited by the diffusion of a practical knowledge of the subject among the general medical profession. The recognised want of such knowledge is largely due to the fact that, with few exceptions, it is only within a comparatively recent period that this important branch of medical science has been sys- tematically taught in medical schools. Furthermore, it is well known that but few of the schools wherein such teaching is now had are able to pro- cure the necessary material for clinical instruction in psychiatry outside of hospitals for the insane; and inasmuch as it is only from public institu- tions that such material can be drawn, it would seem that no greater ob- jection could properly be raised to the giving of such instruction, under proper restrictions, in hospitals and asylums for the insane, than to the clinical teaching of other branches of medicine in general hospitals, a prac- tice which now extensively prevails throughout the civilised world. There being large numbers of patients in the public hospitals for the insane who would offer no objection to the giving of clinical instruction to students of medicine in their presence, the commission would earnestly recommend that the Board of Managers of the several State hospitals afford to medical colleges situated in their vicinity, as well as to the prac- ticing physicians who may desire to avail themselves of the privilege, such facilities for the clinical study of mental diseases, as in the judgment of the medical superintendent may be wise and proper. By the Commission. T. E. McGARR, Secretary. THE PRESIDENT'S ANW UAL ADDRESS. 29 This recommendation of the Commission has its in- spiration in their desire to give to the student of medi- cine an opportunity to enter this field of study, which, until a comparatively recent time, has been so much neglected by a large part of the medical world. It gives authoritative sanction to clinical instruction in the State hospitals, which, if properly utilised, will advance edu- cation in our medical schools, and place it within the power of every physician to equip himself more thor- oughly for the duties and responsibilities of professional life. In closing, we would enforce the plea for making the study of psychological medicine obligatory upon all students, and would urge upon our schools the necessity of adding the theoretical and clinical study of insanity to their curriculum. It is done in Great Britain ; why should it not be done in America . PNEUMOTOMY FOR RELIEF OF TUBEROULAR ABSCESS AND GANGRENE OF THE LUNG; TWICE ON THE SAME PATIENT. RECOVERY. By John BLAKE WHITE, M. D., of New York County. Movember 15, 1892. Up to nearly twenty years ago the annals of Surgery were silent respecting operative procedures upon the lungs. Dr. Rickman J. Godlee, a well-known authority on this subject, considers the surgical treatment of pulmonary cavities to be still in its infancy, and believes that it is destined to be more frequently employed, and with better results. While it is quite true that the great father of medicine, two thousand years ago, re- ferred to abscesses located within and without the lung, and even defined the point of selection for operating and draining them, to Estlander belongs the credit of Origi- nating and establishing in our day the surgical treat- ment of diseases of the lungs. It is in this class of cases especially that a prompt and correct diagnosis is an essential condition to cure. As Soon as the character of the case has been determined, operative procedures should at once be instituted, for, although Ordinary abscess of the lung may terminate in recovery, no case of gangrene of the lung has been known to recover without surgical interference. I purposely exclude from consideration in this paper all empyemas, confining my remarks strictly to pulmonary abscesses. Morton, of Philadelphia, in 1837, in his work on con- Sumption, related a very interesting case of tuberculous abscess of the lung, communicating by a fistulous canal PWEUMOTOMY. 31 with an abscess on the back. With our present knowl- edge, this case would probably not have terminated fatally. The patient, previous to his admission to the hospital, had a slight cough, accompanied by severe pain between the shoulders, especially on the right side, and by haemoptysis. After a time a swelling appeared on the right side of the chest between the base of the scapula and the spine. Two months later there was hectic, with profuse and purulent expectoration and oc- casional haemoptysis. The tumor was elastic, and evi- dently contained air. After internal medication had been used ineffectually for six weeks, the tumor ruptured spontaneously, and discharged a large quantity of foetid pus, of the same character as that expectorated. The opening was then enlarged, and a pint of pus evacuated ; but the relief was only temporary, and the patient died four days later, no doubt from septicaemia. Dr. Samuels," has reported a case seen by him in the London Chest hospital. There were the physical signs of fluid in the chest, considerable fever, night-sweats, and abundant foetid expectoration. Upon inserting an aspirating needle between the fifth and sixth ribs, two ounces of foetid pus were withdrawn. This was followed by considerable tumefaction at the site of puncture, and on incising this, about three ounces of pus escaped. The cavity was washed out and drained. Subsequently the seventh rib was resected, and a cavity in the lung the size of an orange was discovered. The patient died suddenly on the fourteenth day, immedi- ately after an epileptiform seizure, in which there was paralysis of the right arm. Dr. A. W. Meigs” has reported the case of a boy, eight years old, who had been ill for three years previous to Coming under his care. The trouble began with an acute abscess of the lung. Examination of the right lung revealed dullness in the region of the third rib, with *Medical Press and Circular, 1887. *Archives of Pediatrics, 1887. 32 NEW YORK STATE MEDICAL ASSOCIATION. “cracked-pot” sound extending down to the liver. The respiratory sounds were harsh ; there was prolonged ex- piration at the base of the lung posteriorly; and here the respiration was feeble and harsh, and percussion showed dullness over this area. Large quantities of pus were expectorated after violent paroxysms of coughing. Dr. Meigs believed from the symptoms and distinctly clubbed fingers, that there was a cavity in the chest containing pus. An incision was made, free drain- age was established, and the patient recovered. The following case of gangrene of the lung cured by a surgical operation has been reported by Drs. Paul and Perier : * A man, fifty-eight years of age, was attacked by a severe bronchitis, and soon developed all the symptoms of gangrene and of Septicaemia. Cavernous sounds were most intense over the second intercostal space, so Dr. Perier made an incision here, seized the lung with a pair of very fine forceps, and kept it in contact with the pari- etal pleura while an incision was made into the lung, and the wound enlarged with forceps. On introducing the finger, a round opening was felt. After thoroughly cleansing this cavity, two drainage tubes were inserted side by side, and the wound closed. Air circulated freely through these tubes at each inspiration and expiration. The fits of coughing ceased at once, the odor disappeared from the sputa, and the fever subsided. Two weeks after the operation, the drainage tubes were re- placed by a piece of Salol gauze, and at the end of seven weeks the wound had healed, and the patient was com- pletely restored to health. Dr. Runeberg,” of Sweden, has described a successful case of pneumotomy for pulmonary abscess following pneumonia, and has collected eleven similar cases. Dis- carding three of these on account of uncertainty as to the diagnosis, there remain eight cases, three of which 1 Bulletin de l'Académie de Médecine. * London Medical Record. PWEUMOTOMY. 33 resulted fatally, though death was not attributable to the operation. He believes pneumotomy indicated when the diagnosis is clear and the abscess accessible, but deprecates the use of antiseptic irrigations, as he con- siders thorough drainage sufficient. Among other authorities may be mentioned Dr. Arthur Neve," who reported a case of abscess in the upper and anterior part of the right lung, which was operated upon successfully. Drs. Bearman and Pengreuber” have re- ported a case of pneumotomy for the relief of an abscess located in the middle portion of the right lung. M. Pasteur” has recorded a very interesting case of gangrene of the lung occurring in a boy seven years of age. The amount of repair which took place under unfavorable circumstances was most encouraging, and seemed to indicate that an earlier operation might have saved the patient’s life. Thiriar * has operated successfully upon a case for the relief of an empyema, communicating with an abscess cavity in the right lung. I now ask your attention to the following case, which occurred in my own experience: On April 8, 1889, Miss A—, thirteen years of age, having a tubercular family history, was attacked with croupous pneumonia of the right lung. During this illness she was under the care of Dr. T. A. Pease, of Norwood, N. Y., and was also Seen in consultation by Dr. J. Reynolds, of Potsdam. The pneumonia ran a favorable course, and, as Dr. Pease reported, reached a crisis on the morning of the ninth day, when resolution began, and from that time on the patient improved rapidly, so that the temperature, pulse, and respiration became normal within three weeks. At this time there was no cough or expectoration except that resulting from a chronic catarrh of the air passages, to which she had been subject since she was three years * London Lancet. * New Orleans Medical Journal. * London Lancet, Oct. 20, 1889. * La Semaine Medicale. 34 NEW YORK STATE MEDICAL ASSOCIATION. of age. At the end of the second week of convalescence, the temperature rose to 102° F., the respiration became more labored, the cough spasmodic, the expectoration difficult and scanty, and there was very pronounced pain and tenderness about the affected side. Dullness on percussion now extended from the angle of the scapula until it involved the entire lower half of the lung, both anteriorly and posteriorly. The case was now believed to be one of interstitial pneumonia with fibroid degeneration and infiltration. This condition, with temporary improvement and relapses, and with marked disturbance of the digestive functions, continued until the case passed out of the hands of Dr. Pease. The care of the case next devolved upon Dr. Reyn- olds, of Potsdam, who continued in attendance until January 1, 1890, when the patient was taken to the Adirondacks for several weeks, whence she was brought to New York. Soon after her arrival in New York, I was summoned to see her, and upon examination, found her suffering from an acute broncho-pleuro-pneumonia engrafted upon an old unresolved pneumonia, which had degenerated into a fibrosis of the right lower lobe, and a part of the middle lobe. She was under my care about two weeks. After she had recovered sufficiently from the attack, she was carried to Thomasville, Ga., where she remained under the care of Dr. Cortelyou until the end of the following spring, when she returned to Nor- wood. Soon after reaching home, she was again placed under the care of Dr. Pease, from whom I received the following account of her condition: “Miss A– coughs less than before her trip South, and her respiration is improved, though marked dullness is present over the central portion of the right lung, with loud, moist rāles on auscultation. Last evening she was brought into my office, retching, vomiting, coughing and expectorating an intolerably foetid greenish matter. She continued to expectorate large quantities of this offensive Sputa, and was frequently harassed by violent par- PWEUMOTOMY. 35 Oxysms of coughing, accompanied by most painful irri- tation of the larynx, and frequent emesis.” All internal remedies judiciously and skillfully em- ployed by Dr. Pease having proved unavailing, and the case increasing in gravity, a consultation was determined upon, and I was called to Norwood. On my arrival, July 26, 1890, I proceeded, in company with Dr. Pease, to examine the patient, and we speedily came to the conclusion that a large area of the right lung had become gangrenous, and that there was an abscess communicat- ing with a bronchus. An exploratory puncture con- firmed this diagnosis. The patient presented a pinched and extremely cachectic appearance; indeed, her condi- tion seemed in every respect so critical that we thought no time should be lost, and determined to operate at an early hour on the following day. Assisted by Drs. Pease and Larkin, of Norwood, the patient being under the influence of chloroform, I pro- ceeded to make an incision in the sixth intercostal space, about one inch anterior to the axillary line. The dif- ferent layers of tissue, including the pleura, were in turn divided, and a careful examination made of the Seat of the lesion. When the finger was pushed through the intercostal space, it came in contact with the smooth Outer surface of condensed lung. A fluctuating spot Was discovered, through which the point of the knife Was directed. This liberated about two ounces of very foetid pus, having the same odor as that which had been expectorated. The wound was next irrigated with an antiseptic solution, a drainage tube inserted, and anti- Septic dressings applied. The patient slowly rallied after the operation, with the aid of hypodermic injections of brandy and digitalis. There was an immediate relief of all distressing symp- toms, and after a few days of depression, she began to improve, and continued to gain strength until the dis- charge ceased. The cavity continued to drain, until, at the expiration of two months, the discharge was so re- duced that it was judged expedient to remove the tube. 36 WEW YORK STATE MEDICAL ASSOCIATION. However, a month after the removal of the tube, urgent symptoms again set in ; there was a distressing, paroxyS- mal cough, with fever, and such an offensive greenish expectoration that it often excited nausea and vomiting. Dr. Pease discovered an area of dullness in the posterior aspect of the lower right lobe, and again summoned me to visit the patient, which I did on the 22d of September, 1890. Upon examination, I found quite a favorable con- dition about the seat of the previous operation, but dis- covered a region of decided dullness in the posterior part of the lower lobe, extending upwards under the angle of the scapula. With the assistance of Dr. J. Reynolds, of Potsdam, and Drs. Pease and Larkin, of Norwood, I re-opened the thorax, one inch posterior to the axillary line. There was present the same condi- tion of the lung as at the first Operation. On Opening the cavity, several ounces of very foetid pus escaped, along with fragments of necrotic tissue and a portion of gangrenous lung containing the remains of a well-defined ruptured bronchus. A good-sized soft rubber tube was inserted, and after thoroughly washing the wound with an antiseptic lotion, appropriate dressings were applied. For three weeks there was a free discharge of foetid pus, but the patient was immediately relieved of cough, ex- pectoration, and septicaemic symptoms. Air circulated freely through the drainage tube, on both inspiration and expiration, and often, during the process of irrigat- ing the cavity, the antiseptic solution would be coughed up. The tube was not removed for eight months. Two years have elapsed since the last operation, and the patient now has better health than she enjoyed in early childhood. The menstrual function, which had been arrested during her illness, was re-established in the November following the last operation, and was accom- panied by a marked disturbance of the whole system. The clubbed finger nails which so disfigured her hands have disappeared. She is able to take a full amount of exercise, and is at present in perfect health. PWEUMOTOMY. 37 In this case, regular irrigations with a mild solution of peroxide of hydrogen proved decidedly beneficial. Nevertheless, there is every reason for the exercise of great caution in the irrigation of pulmonary cavities. The danger of too frequent and indiscriminate irrigations of pus cavities in the lungs, is strikingly shown in a case reported by W. Pasteur,” of London, in which the pa- tient was signally relieved by the operation, but sank rapidly on the tenth day. Bowditch, of Boston, con- demns too diligent washing out of pus cavities, pul- monary and pleural—an opinion which meets with my support ; and he further ventures the statement that the proportion of cases in which irrigations might be re- quired, is possibly one in four hundred. I am, however, of the opinion that in gangrenous cavities, such as the one under consideration, irrigation is safer than in cavi- ties discharging laudable pus. I have seen, in consulta- tion, an instance of metastasis to the shoulder joint, which promptly followed irrigation of a pleural pus sac. So serious was the involvement of the joint, that an operation was required for its relief. The patient, however, ultimately made a good recovery, without any impairment of the use of the joint. In the performance of all operations on the lungs, the strictest and most diligent observance of antisepsis should be unfailingly carried out. Cases of gangrene of the lung are never too far advanced for surgical inter- ference, even though presenting evidences of profound Septic contamination. Spillman and Haushalter con- sider it necessary to excite adhesion of the pleura before Operating, but I do not consider this an essential pro- Cedure, and though it may be a more favorable condition under which to operate, delay for pleural adhesions to OCCur, might prove, in some instances, decidedly unsafe. Resection of the rib is seldom required in the very young, except to facilitate the discovery of an abscess in Obscure cases. * British Medical Journal, Oct. 20, 1888. 38 NEW YORK STATE MEDICAL ASSOOIATION. The corrugated white rubber tubing similar to that herewith exhibited, and used in the case just reported, proved far more useful for the purpose of drainage than the ordinary soft rubber tubing usually employed. My attention was first called to the value of this kind of tubing for drainage tubes, by Dr. Egbert H. Grandin. I have found it much less liable to compression, and the resulting occlusion of its calibre by the intervention of granulation tissue, and I feel quite Satisfied that it main- tains better, as well as longer drainage, in addition to its being as well tolerated by the patient. DISCUSSION. DR. J. G. TRUAx, of New York county, said he wished to thank the author for his paper, and also to add his own experience on this subject. Within the last five years he had operated twice for abscess of the lung. In one case, that of a child about eight years of age, he simply performed aspiration of the lung, and the child made a good recovery. The second case was a male adult, from whom he removed a portion of a rib, opened the abscess, introduced a tube, and kept up irrigations for about two years, during all of which time there was more or less discharge from the abscess cavity. He had not been able to obtain the man's subsequent history, but he had been informed that the patient was now dead. Twice the tube was removed, and the external wound allowed to heal over ; but both times he was compelled to re-open the wound on account of the pent- up discharges. His cases had never been published, and he could not recall all the details, but they fully confirmed the statements made in the paper. DR. E. D. FERGUBON, of Rensselaer county, wished to Bay in connec- tion with the specimen of rubber drainage tubing which had been ex- hibited by the author, that a drainage tube should possess two essential qualities, viz., one, the ability to maintain its tubular character, and the other, sufficient elasticity to prevent doing harm to the walls of the cavity in which it rest8. In the walls of a pulmonary cavity, for instance, it is Quite possible, if the tube be allowed to remain for a considerable time, for a process of ulceration to be cstablished by the portion of the tube lying within the cavity; and this might occur even with tubes having the firmness of those just exhibited. IIc was satisfied that in draining such an Organ a8 the lung or the kidney, considerable judgment is required to determine the proper structure and resiliency of the tube to be employed. In his own practice, he had 80ttled this point by employing a double tube; the Outer one, which passes through the parietes, or through a sinus, where the pressure is considerable, being more resilicnt to lateral com- pression than is the inner tube, which is much Hoſter, but still sufficiently firm to keep its form and Secure proper drainage. TRAUMATIC OSTEO_ARTHRITIC LESIONS WHICH INVOLVE THE PROXIMAL SEGMENT OF THE ANKLE_JOINT : THEIR PATH_ OLOGICAL ANATOMY AND TREATMENT. By THOMAS II. MANLEY, M. D., of New York County. November 15, 1892. Physical violence is frequently a cause of more or less serious injury to the anatomical structures which com- pose the ankle-joint. There are few who have reached or passed middle-life, who have not at some time so wrenched this articulation, that they have experienced more or less temporary inconvenience. The ankle-joint, though subjected to the greatest strains, manifests in a singular degree the power of resisting inflammation, and is seldom permanently an- chylosed as a consequence of vulnerating force. Al- though classified by anatomists as a ginglymus, never- theless, well-marked, though limited motion, is permitted in the direction of abduction, adduction, and rotation. The head of the astragalus is the fulcrum for the lever- age of the distal end of the tibia. This joint is supported and powerfully acted on by four sets of tendons, which Cross it anteriorly, posteriorly, and laterally—the two former in locomotion, and the latter chiefly in steadying the leg on the foot. The ligamentous envelope which Sheathes the tendons and binds the malleoli to the astragalus, is of great density and strength, and, like the tendino-ligamentous insertion of the quadriceps into the patella, is so firmly incorporated with the external Surfaces of the bones that, when subjected to sudden and Severe strain, the bone gives way before the ligaments divide. The ankle-joint is so formed that, without its 40 JNETW YORK STATE MEDICAL ASSOCIATION. extensive tendinous and ligamentous braces, luxation would be a common event. In its normal state, this is scarcely ever possible without fracture of the epiphyseal ends of the tibia or fibula, or both. In lesions, attrib- utable to indirect violence, where the force is expended on the tibio-tarsal articulation, the tarsus, astragalus, and calcaneum are always passive agents, while the sole active factors are the leg, or the articular ends of its two long shafts. Although the epiphyses of the tibia and fibula appear before the third year, their complete union with the diaphyses is not effected until the twenty-fifth year. According to Cloquet,' this process of development is sometimes delayed until the fortieth year, and the pro- cess of Ossification may remain imperfect through life. The tibia and fibula are bound firmly together at the ankle-joint by a strong ligamentous band, which makes their separation difficult. The fibular shaft, inferiorly, except within an inch of its distal apophysis, is every- where covered by muscular tissue, and is bound to the tibia above the ligament by the interosseous membrane. The long, broad, flange-like process of the fibula, which constitutes its inferior articular end, extends much far- ther down the lateral wall of the astragalus than its fellow. Its articulation with the head of the astragalus, though continuous with that of the tibia, is wholly lat- eral, while the major portion of the articular surface of the tibia is horizontal. The function of the fibula, then, is limited to steadying, and not supporting, the leg on the foot. The head and shaft of the fibula are of more. compact structure than cancellous tissue, and hence are less resilient, and more brittle than the tibia. The inner surface of the latter bone, from its superior to its inferior articulation, is wholly uncovered by muscular tissue, and as this bone is subjected in locomotion to constant concussion, it is rich in cancellous tissue, and is elastic. * Anatomie des Os du pied, p. 167, Cloquet. 1 Anatomie des Articulations, p. 203, ed. ii. LESIONS OF THE ANKLE, JOINT. 41 Having thus far examined very briefly the structures which enter into the proximal segment of the ankle-joint, and the parts with which they are in immediate contact, it will be more easy to appreciate those abnormal condi- tions which occur here as a result of accident. These may be divided into lesions of the soft parts, and lesions of an osteo-arthritic character, in which fracture and dis- location are combined. Free action at the ankle-joint may be destroyed, and a permanent crippling remain after a severe sprain at this articulation, which in no way primarily affects the bones. Many of these sprains give as much pain as a fracture, or require a longer time to recover. In order to estimate the extent of injury, as well as to forecast the probable results, we must consider the pathology of a severe sprain ; and, at the outset, it may be well to remember that the appearance of the soft parts which enclose the joint, or are continuous with it, often bears no relation to the gravity of the injury. When the sprain is severe, it may be quite impossible to put any weight whatever on the foot, and in the milder forms, there is always a free extravasation of blood into the capsule of the joint, often associated with a lacera- tion of, and leakage from the thin-walled veins in the cellular membrane. Haemorrhage into a joint is quickly absorbed and gives rise to little inconvenience, the over- tension of the tendons and contusion of the parts yield- ing promptly to the bath, bandage, and rest. In a severe Sprain of the ankle, important structures have been Severely injured, and limitation of joint-action is sure to follow, if active and appropriate measures are not em- ployed early. In many instances, the ligaments have been ruptured, the nerves over-stretched or lacerated, the capsule of the joint over-strained, so that the peri- Osteum or the cancellous structure of the bones may undergo inflammation. When the injury has not been Very great, and the patient has a sound physique, full functional restoration is generally secured. 42 NEW YORK STATE MEDICAL ASSOCIATION. Certain sprains of the ankle attended with over-strain of the tendons, and followed by inflammation of the synovial lining of the thecal envelopes of the tendons, by synovitis, neuritis, periostitis, and arthritis, may end in anchylosis or muscular atrophy, with a weak, pain- ful articulation. In one such case which I saw, although there was moderate motion in the joint, there was a most acute hyperaesthesia along the cutaneous filaments of the internal division of the plantar and internal saphen- ous nerves, exhibited on the slightest motion, and loco- motion, without the aid of crutches, was for a long time quite impossible. In all the other muscular or Osseous cases which I have examined, there was anchylosis present. In some of them, the sural muscles were re- tracted, requiring the use of a raised heel in walking. It goes without saying that, should a joint be kept im- mobilised sufficiently long, muscular wasting must in- variably follow, with degenerative changes in all the structures of the leg, ankle, and foot. CONTUSIONS OF THE ANEKLE. Contusions of the ankle are always the result of direct violence, such as kicks, blows, or crushing injuries. The lower third of the leg is almost devoid of muscular tissue, as it is here that the greater part of the muscles taper into tendons. In females, the bones in this region are well covered with a thick layer of adipose tissue, but in the healthy, active male, little fat is lodged here, and the bones and sinews are very superficial. This is pre-eminently the region of the body in which the conse- Quences of degenerative vascular changes may be most frequently seen and studied. It may be said that fully 25 per cent. Of all adults present disturbances of nutri- tion in the lower region of the leg, the skin and subcu- taneous cellular tissue undergoing atrophic changes, and the walls of the superficial and deep veins becoming dilated. The periosteum suffers from the effects of this impaired circulation, and the osseous tissues of the tibial LESIONS OF THE ANKLE-JOINT, 43 diaphysis are nourished by the deep arterial vessels in the Haversian canals rather than by those On the peri- phery. As a result of these pathological changes, the bone becomes fragile, and is never again capable of per- fect repair. It is clearly apparent, then, that age and the previous condition of the parts at the seat of injury, must always very largely determine the ultimate results in every case of severe contusion in the vicinity of the tarsal ends of the tibia and fibula. The degree of momentary com- pression to which the skin may be subjected, without destroying its vitality, or causing a fracture of the un- derlying bone, is astonishing. Many cases of this de- scription have come under my observation, but it was not until it had been proven in courts of justice, and I had examined several well-attested cases, that I could convince myself that it was possible for the wheel of a railway street-car to roll over the leg without inevitably destroying the tissues at the seat of injury. Certainly, the rate of speed and the weight of the car have much to do in determining the character and extent of the injury. LESIONS OF THE SOFT PARTS OVERLYING THE TIBIO- TARSAL ARTICULATION, ASSOCIATED WITH DISLOCATION, FRACTURE, OR BOTH. The force necessary to Sunder the tendino-ligamentous junction at the ankle sufficiently to separate the head of the astragalus from the articular ends of the tibia and fibula, and open the joint, almost invariably causes such complete disorganisation of the blood-vessels and nerve- trunks as to render amputation imperative. Such an injury always results from direct force expending its energy on a large area. In this class of cases, the shock to the system is always well marked, and even though Complete reduction is possible, a painful, palsied, or an- chylosed joint remains. A complete compound disloca- tion of the head of the astragalus out of the tibio-fibular 44 NEW YORK STATE MEDICAL ASSOCIATION. mortise I have never seen, nor can I find Such a case OIL record except in injuries causing destruction of the joint. A partial dislocation at the ankle-joint in any direction is very rarely witnessed, without fracture of the diaphy- sis of the fibula and a diastasis of the apophysis of the tibia; in other words, the actual condition commonly encountered is a fracture-dislocation, the morbid anat- omy of which is limited to a physical disorganisation of the bones, with a displacement of their articular sur- faces, attended with haemorrhage, laceration of the soft parts, and a condition favorable to the advent of inflam- matory changes. This brings us to a consideration of what is at present commonly designated Pott’s, or Dupuytren’s fracture of the fibula. As this lesion derives its greatest interest and importance from the distortion or dislocation, which leads often to ultimate limitation of motion, this feature deserves special attention. POTT'S FRACTURE–DUPUYTREN’S FRACTURE–FRACTURE AND DISLOCATION OF TIIIE TIBIA AND FIBUL.A. This lesion, which is limited to the ankle-joint in the typical form, must always be regarded as a very grave injury; for, notwithstanding what may be said to the contrary by contemporaneous writers, our most improved methods of modern surgical treatment have rendered us little, if any, aid in obviating the diminished strength, joint-action and deformity, which, in the hands of the most experienced, may occasionally follow. In many respects this injury resembles a Colles’ fracture, a con- dition which, in spite of the almost endless varieties of apparatus devised for its treatment, has thus far defied surgical art, and, in a certain number of cases, has left the patient with a crippled or deformed hand. Both are fracture-dislocations, occurring, with very rare exceptions, in adult life, and in consequence of in- I, ESIONS OF THE ANKLE-JOINT, 45 direct violence. Like Colles' fracture, the typical injury in Pott's fracture is not so much confined to the bone elements as to the soft parts—the synovial membrane, vessels, nerves, and tendons. The typical tibio-tarsal dislocation, with a diastasis or fracture, like the fracture- dislocation of the radius and ulna, is happily not com- mon. In a statistical table of all the fractures treated in the Harlem Hospital in-door service, which has been very kindly prepared for me by Dr. George D. Kahlo, the present house-surgeon, it will be seen that in 1,045 fractures of all kinds, there are but forty-four set down as Pott's fractures. About two-thirds of these came under my care, and I may say that there was not a single one which remained with us during the entire course of treatment, which did not yield to simple measures, and quit the service with fairly useful joints, and little, if any, appreciable deformity. We have been fortunate ; the arthritic lesions were not of a serious character, or our results would have been different. Many of these tabulated cases occurring in my service were not examined by me, as the splints had been ad- justed before I saw them ; and hence it is probable that Several of them were diagnosticated by the internes as Pott's fracture, which were wanting in all the essentials Of that fracture. In no other way can I account for the discrepancy between our figures and Malgaigne's tables. He collected 160 cases, and found that they constituted but 3 per cent. of all the fractures which entered his Service. He saw no case under fifteen years, and but two over seventy years. In Dupuytren’s 207 collected cases, 2 per cent. of all fractures, but 10 per cent. oc- curred in females. Seven-tenths occurred on the right side, and nearly two-thirds were met with in the winter Season. This author maintained that fracture of the fibula was always consecutive to that of the internal malleolus. Malgaigne' fixed the heel of a cadaver in a vise, and * Malgaigne: “Elementes de Chirurgie,” Frac. and les Disloc., p. 307. 46 WEW YORK STATE MEDICAL ASSOCIATIOW. made forcible abduction, when he found that the internal malleolus fractured before the fibula. He then reversed the experiment, using the foot as a lever, and making forcible abduction, but with the same result. On the contrary, Maissoneuve,” repeating this experiment, found that on making abduction, the internal lateral ligament was sometimes completely ruptured, without fracturing either malleolus; though, when this occurred, the force spent itself on the tibio-fibular ligament, and diastasis at the tibio-fibular articulation followed, permitting of a twisting, rotary motion, and fracture of the fibula. Some distance from the joint. Stimson’s” experiments on the cadaver seem to bear out Maissoneuve's observations, for he says: “It will be Seen that by fixing the leg and forcing the toes outward, while the ankle is held at right angles, the first to yield is the exterior tibio-fibular ligament; then the anterior fibres of the internal lateral ligament, and almost coin- cidently the fibula breaks by the twisting of its lower end,” etc. This author claims that the same sequence occurs clinically. The results of the experiments of these distinguished authors are hard to reconcile, except on the ground that the subjects experimented on were of different ages, and the quality of force employed was variable. In any event, deductions from such experimental work on the dead body possess at best but a relative value, and can under no circumstances be regarded as definite and con- clusive. Such are the theories, from an experimental stand- point, as to the causation of Pott's fracture ; but, as we are dealing with lesions in the living subject, it may be well to stop for a moment and review the influences which bring about during life the so-called fracture of Pott. We must not lose sight of those innate influences in the bones themselves. This fracture is scarcely ever 1 Maissoneuve : “Fracture du Perone,” etc., p. 172. * “Pott's Fracture at the Ankle,” Mass. Med. Soc., June, 1892. I, ESIOWS OF THE AWAOLE, JOINT, 47 seen until the processes of Ossification are complete. The premature ossification of the bone, or a preponderance of compact non-vascular tissue, may favor a morbid brit- tleness, so that a wrench or twist may produce what is known by the French as fracture par arrachment, in- stead of simply a severe sprain. Y AIRIETIES OF FRACTURE-DISLoCATION AT THE ANEKLE-JOINT. It has been seen that it is only when the extent of dis- location is considerable, the displacement and laceration of nerve, tendon, and ligament is extensive, and when a double fracture occurs, that a serious condition is present. But there are many intermediate phases, and it is as absurd as it is erroneous to assume that every case of tibio-fibular distasis, or apophyseal separation of the tibial flange, with or without fracture of the fibula, is a grave injury, demanding special and protracted care. In those cases in which the extent of separation of the fragments of the broken internal malleolus, and the degree of deformity is not great, reposition and retention are not difficult. When the head of the astragalus has sprung back into its socket, thereby maintaining perfect extension, the interosseous membrane aids in fixing the fibula, so that no matter how oblique the fibular fract- ure may be, its coaptation and solid union are readily effected. In a severer form of Pott's fracture, intra-articular haemorrhage, cellulitis, and synovial inflammation are complications which may greatly retard recovery, or terminate in an inflammatory infiltrate of Osseous or other cellular deposits, external to the articulation. This may cause undue pressure on the neural cords on their way to the foot, or on the blood-vessels. But, the imOst serious and unmanageable of all phases of fracture- dislocation at the ankle is when, along with a double fracture, the internal lateral ligament is completely torn 48 WEW YORK STATE MEDICAL ASSOCIATION. in two on the same line as the fracture of the tibial apo- physis. By this rupture, the equilibrium of the joint is lost; the foot fixed, with the weight of the body concen- trated on the horizontal articular surface of the tibia, which has now lost its moorings, turns on its own axis, and, in this twisting motion, sunders the tibio-fibular union; and the same spiral motion, ascending, splits the shaft of the fibula in its most brittle and exposed part. The head of the astragalus having left its mortise, may Occupy various relations with the articular surface of the tibia. Now, the spasmodic contraction of the powerful and unopposed muscles of the leg, acting on the foot, tears the capsule widely open, and causes contusion and laceration of the vascular and neural elements lying in close relation to the joint. Inflammation inevitably fol- lows, and it is quite inconceivable that after such an injury anything like perfect functional restoration is possible. This latter, type, then, and this only, is what Percival Pott so fully and clearly described, and it is the only fracture at the ankle which should bear his name. DIAGINOSIS. When there is a difference of opinion as to the precise morbid changes which constitute a certain specific lesion, it is clear that a definite diagnosis is difficult. This is particularly the case with apophyseal fractures. It is most unfortunate that this injury should have been designated Pott's fracture, for the theory of causation as described by the English surgeon, and the principles of treatment formulated by him, were disputed by Dupuy- tren, and have, in large part, been recently ignored by Stimson. This wide divergence of opinion on cardinal features implies that these surgeons did not observe quite the same lesion. It would greatly aid in diagnosis . if this so-called Pott's fracture were simply designated “fracture-dislocation ” at the ankle-joint. In another LESIOWS OF THE AWKLE-JOINT, 49 type of fracture-dislocation, the internal or the external lateral ligament has given way, thus permitting a rolling of the head of the astragalus, inward or outward, with an inversion or eversion of the part. When there is complete separation and mobility, these fractures may be readily detected at the first examina- tion. If there be no displacement, unless the muscles are well relaxed and considerable force is employed, crepitus will be absent, and it will often be difficult to determine the presence of a fracture. Under these cir- cumstances, the employment of an anaesthetic and of violent manipulations must be condemned. One should always hesitate before making a diagnosis of Pott's fracture; for the profession, as a whole, has an exaggerated notion of the seriousness of this lesion; and, as has been pointed out, it is only in those cases attended with marked, irreducible dislocation, and ex- tensive damage to the arthritic structures, that this designation is at all applicable. TREATMENT OF SPRAINS, CONTUSIONS, AND FRAC- TURE-DISLOCATIONS AT THE ANKLE-JOINT. The treatment of sprains and contusions may be studied together, for the same line of treatment applies to both, when there is no laceration of the skin. Our treatment should vary with the pathological condition present. If called immediately after the injury, our efforts should be directed to relieving pain and preventing the develop- ment of inflammation. The limb should be placed in an elevated position, and well supported; the use of the bandage will depend on the manner in which it is toler- ated. In most cases, if applied before the Supervention of inflammation, it is of infinite value in relieving the ar- terial throb, overcoming muscular spasm, and steadying the joint. When there is very much pain, with or with- Out tumefaction, and a sanguineous effusion into the capsule or soft parts, the free application of leeches is a powerful prophylactic against subsequent inflammation. 4 50 NEW YORK STATE MEDICAL ASSOCIATIOW. Bathing, either cold or warm, rubefacients, or counter- irritants, will be required in many cases, and will serve a useful purpose. - One of the most important questions of late years, in the surgical treatment of severe joint contusions and sprains, is that of immobilising the limb–giving it rest, as it is said. Immobilising a sprained ankle-joint by plaster-Of-Paris, is a practice which cannot be too strong- ly condemned. It is true that the injured part needs temporary rest; but it is physiological, not mechanical rest which is required. Physiological rest must not be confounded with immobilisation. The joint may be am- ply supported by the simplest splint which will permit of ready removal, moderate motion, massage, the appli- cation of medicaments to the bandage, and other measures; but, with the knee flexed, the Sural muscles relaxed, a well-padded bandage applied, and the limb properly supported, splint is very often unnecessary. Since, then, any sort of permanent fixation is so liable to be followed by anchylosis, we must be on the alert for this unfortunate sequela ; for ordinarily we are responsi- ble for its occurrence. It is surprising with what rapidity degenerative changes occur in contiguous parts, after joint injury, when all joint motion is completely arrested. There is in the child an immediate cessation of growth, and in the adult, the nutritive processes are so profoundly affected, that atrophic and degenerative changes pursue Such a swift and destructive course, that after the lapse of but a few weeks, all hope of restoration of normal joint-action is forever destroyed. Passive motion, then, should be contemporaneous with other measures. When this gives rise to such unbearable pain that it cannot be practiced, we may be assured that the brunt of the in- jury has been borne rather by the bone than by the soft parts, and that pathological changes are advancing in the bone elements, which we can only modify or arrest by bold and prompt antiphlogistic procedures. LESIONS OF THE ANKLE-JOINT. 51 It is obvious, then, that we must treat severe ankle- joint concussions, or twists, with promptness, energy, and patience, avoiding above all things protracted im- mobilisation; and, in children, in whom arrest of growth in the affected limb, means a crippling for life, no device should be employed which might seriously interfere with the nutritive processes. Should anchylosis, however, follow our treatment, or be present when we are called to attend the case, let us be assured that it is a stiffening of the joint arising entirely from molecular organic changes, before we decide that it is beyond relief, and are content with the let-alone policy. I have seen quite a number who have been entirely cured of their lame- ness, more than a year after their injuries, by thoroughly breaking up the adhesions in and about the joint. Of course, it is needless to say, that before One undertakes to break up an anchylosis, one must very carefully examine the bones, and test the muscles, or One will, in unfit cases, surely fracture the shafts, as I did myself in two patients, very early in my experience. In both cases, the bones were less fragile, than the adhesions, as a result of pathological changes. The management of Pott's fracture, is very variously described in our different treatises on fractures. Dupuy- tren and Hamilton bound the foot and leg to an internal splint, with the foot markedly adducted, the several muscles being relaxed by the bending of the knee. Pott himself said little about splints, but attached great im- portance to posture. Speaking about this, he said: “The limb should be laid on its outside, with the knee moderately bent ; by this the muscles forming the calf, and those tendons which pass behind the fibula and under the os calcis, are all put in a state of non-resistance, When all trouble and difficulties will vanish immediately. The foot being easily placed right, the joint reduced, and by maintaining the same disposition of the limb, everything in general will succeed very happily, as I have often experienced.” - 52 NEW YORK STATE MEDICAL ASSOCIATION. The more modern plan of fixing the fragments and the joint, is by splints applied about the articulation, the limb being extended, and resting on its dorsal aspect. Such is the plan recently recommended by Prof. Stim- Son. But let us not forget that we are something more than moving automatons, and that we should treat this injury on sound surgical principles, regardless of the individual preferences of different surgeons. Let us ap- preciate the fact, that we have a fracture, opening into a joint, with more or less displacement of the articular Surface. We cannot provide a new set of ligaments; and, hence, this dislocation may be entirely irreducible, Or, if reducible, it cannot be retained without producing dangerous pressure or anchylosis. When the tibial sur- face is posterior to and below the head of the astragalus, extensive laceration or overstretching of the ligaments is inevitable. Decided, lateral luxation entails rupture of the ligament, with perhaps, a tearing off of a portion of its OSSeous surface of attachment. It is apparent, then, that as this element of dislocation predominates in aggravated cases, its efficient reduction and retention should particularly concern us. For the efficient accom- plishment of this purpose postural treatment occupies the front rank. Muscular relaxation, topical applica- tions, and the bandage with appropriate supports, will, as Pott has well said, suffice in most cases. It must not be overlooked, however, that when considerable joint disorganisation has been followed by active inflamma- tion, defective joint action with deformity can, in no way, be wholly obviated. Whatever line of mechanical treatment may be insti- tuted, it is well to know that this has its limitations, and, if misdirected or too protracted, may conduce to a pathological condition which may render the joint and foot of less use than if nothing whatever had been done. The trophic changes, and loss of function which invari- ably follow, traumatic or pathological, joint lesions and fractures, are clearly and concisely described in a classi- I, ESIOWS OF THE A WHOLE-JOIWT. 53 cal production recently presented before the American Orthopaedic Association by Prof. Roswell Park.” From a study of the experimental and clinical observations of French, German, English and American surgeons, this author concludes that an injury to the shaft of a bone, or to any of the joint structures, which causes protracted inaction or long-continued immobilisation, invariably induces an arrest of growth, degeneration of bone sub- stance, muscular wasting, and impairment, or entire loss of function in the affected limb. Therefore, in fracture- dislocations at the tibio-tarsal articulation, as in a Colles' fracture, or a fracture opening into the elbow-joint, the greatest caution should always be observed in severe cases, to remove every sort of fixation apparatus at the earliest possible date, with a view to commencing passive exercise, and thereby preventing organic changes in the structural elements of the bone and muscles, which might lead to muscular or arthritic anchylosis. For the purpose of maintaining the normal nutrition of the joint, and obviating, as far as possible, Subsequent weakness and limitation of motion, massage, friction, and uniform, but interrupted pressure, are important. The precise time at which manipulations of the ankle should be commenced, will depend, in a certain measure, on local Conditions. If there has been an extensive rupture of ligament and tendon, any disturbance of adjustment- pressure will be immediately followed by a subluxation, SO that immobilisation must be continuously maintained for a considerable period, even at the expense, perhaps, of an anchylosed joint. But this condition is excep- tional. In those cases in which the chief lesion is osse- Ous, the propriety of disturbing the fragments by early handling of the foot, may be questioned, as such inter- ference would seem to retard union. My experience, however, in the treatment of fractures in general, has been, that the changing of dressings, and moderate kneading of the muscles, with slight motion of the frag- * “A Study of Atrophy,” Gaillard's Medical Journal, Oct., 1892. 54 NEW YORK STATE MEDICAL ASSOCIATION. ments, seem rather to stimulate the reparative process. Fortunately, in these ankle-lesions, in which after the most judicious treatment, the range of motion is re- stricted or is entirely lost, the limb often remains firm, and a thousand-fold more useful than any artificial Sub- Stitute. In those extreme cases, in which, through tibio- fibular diastasis and rupture of ligaments, there has been an irreducible axial rotation of the head of the tibia on the articulating surface, with pronounced posterior or lateral displacement, a weakened, crippled joint remains, necessitating for comfortable locomotion the adjustment of some prothetic appliance, which will give ample sup- port. I never undertake to liberate a joint under an anaes- thetic. The two accidents cited, happened while my patients were under ether; while in every instance in which I have been able, without an anaesthetic, to open the surfaces, by a sudden but cautious motion, the result has been good and permanent. In my judgment, it is much better, in genuine, Osseous anchylosis, to divide the tendons, and, if necessary, open the joint, than to apply great force. FRACTURES OF THE FIBULA AND POTT'S FRACTURE. & rc , ºr || || Tº g 3 his DLAGNOSIS. # à § | # * 5 § 3 | # 59 | ## > QD c H C gº o ſº C & § {: E | Q #, P 5, 5 | E-3 Fibulae : Simple . . . . . . . . 22 2 14 10 tº tº & © 13 11 Compound. . . . . 2 e e 2 tº tº tº tº . . || 2 . . Comminuted. . . 1 1 1 Pott’s : Simple . . . . . . . . 36 11 35 12 tº $. tº º 32 15 Compound. . . . . 2 2 2 Total. . . . . . . . 63 13 5 22 tº tº we tº 50 26 Actual number of deaths from fractures, including traumatic am- putations, etc., 117, showing a mortality of 9.4 per cent. of the cases treated. Ratio of cases cured is 70 per cent., which is exclusive of those trans- ferred as improved and unimproved, immediately or shortly following the time of receiving the injury. I, ESIONS OF THE ANKLE, JOINT × 55 RíSUME. POTT'S FRACTUIRE. Number occurring in the male. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38 Number occurring in the female. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11–49 Of the right leg. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 Of the left leg... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 Leg undesignated. . . . . . . . . . . . . . . . . . . . . . . . . .* * * * * * * * * * * * * * * * * * * * 18–49 Age Yr9. No Yr9. JWo. Yr9. Mo Yrs. No 12 1 29 4 38 1 47 1 21 2 30 1 39 2 48 22 1. 31 1 40 3 51 1 24 2 32 1 41 1 52 1 25 2 34 2 42 1 53 1 26 3 35 3 43 1 57 1 27 1 36 1 45 2 65 1 28 1. 37 3 46 1 68 1 Summary of Ages. Yrs. JNo. Yrs. Wo. Y7's. No. Under 20. . . . . . 1 30–40. . . . . . 15. . . . . 50–60. . . . 4 20–30. . . . . . 16 40–50, ..... 11..... Over 60. ... 2 - Classification by Months. Jan. . . . . 6 April. . . . . 2 July. . . . . 3 Oct. . . . . 4 Feb. . . . . 5 May. . . . . . 4 Aug. . . . . 3 Nov... .. 5 March... 5 June...... 2 Sept. . . . . 4 Dec.. ... 6 Summary as to Seasons. Spring, 11. Summer, 8. Autumn, 13. Winter 17. Percentage. Percentage of Pott's fracture to total number of fractures treated (exclusive of those of the metatarsus, phalanges, etc.), 4.009 per cent. FRACTURES OF THE FIBUL.A. Number occurring in the male. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 Number occurring in the female. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2—27 Of the right leg. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 Of the left leg. ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - e º ºr e ºs e º 'º e º e Leg undesignated. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8–27 Age Yrs. JWo. Yºs. Mo. Yrs. Mo. Y78. No: 9 1 23 1 31 1 41 1 14 1 25 1 32 2 45 2 20 1 28 2 33 1 49 1 21 1 29 2 34 2 51 1 22 1 30 1 35 1 56 1 38 1 64 1. Summary of Ages. Yº's JVo Yr9. No Yr9. No Under 20....... 2 30–40. . . . . . . . 9 50–60. . . . . . . 2 20–30. . . . . . . 9 40–50. . . . . . . . 4 Over 60. . . . . . . 1. Classification by Months, Jan. . . . . 5 April. . . . . 3 July..... 7 Oct. . ... 1 Feb .... 1 May. . . . . . 3 Aug. . . . . 1 Nov. . . . . 2 March... 1 June. . . . . . 0 Sept. . . . . 2 Dec. . . . . 1 Summary as to Seasons. Spring, 7. Summer, 8. Autumn, 5. Winter, 7. 3. REPORT OF FRACTURES TREATED AT THE HARLEM HOSPITAL (Evelusive of Phalanges, Metacarpus and Metatarsus, Carpus a nd Tarsus), from DIAGNOSIS. January 1, 1887, to September 1, 1892. Skull; Simple . Compound . © Compound depressed . e e Compound, depressed and multiple Com., compl., commi., depr. Simple multiple e e Simple depressed . Of base . º Nasal bones: Simple Compound te s Zygomatic process: Simple Superior maxilla : Simple. Compound . e * Compound Complicated Inferior maxilla : Simple. Compound & Malar e ſº 0. tº Vertebrae ſº * & Ribs : Simple Compound Multiple Complicated . Pelvis : Ilium . Pubes . º tº Sternum : Complicated Clavicle: Simple . g Compound complicated. .g is 2.3 ## * 2.É. #: Male. || 3 || 3 |E ###| : § 3|É : COMPLICATIONS AND REMARKS. ºr | Q o,IT as C. © 19| ..| 12| 1 || 3| 3| 15 ..] [comp. compl., 1; operation, 2. 33 5, 29| 2 | 6 ||6| 27 . . Of base, 3; radius, 1 ; clavicle. 42 3 27 2. 14 15, 29 . . Operation in 39 cases. 1| 1 iſ . . 1| 1 || 1 ... Of base, 1 case ; operations, 2. 1. . . . . . . 1| 1] . . . . . Gunshot wound. 1] . . . . . . . . . 1 1. . . . . . & g ..] 3 2 . . 1| 1 || 2 | . . 38|| 10|| 5 || 1 || 34; 42|| 5 || 1 4] . . . 4. . . . . . . . . . 4. . . 6|| 1 || 7 | . . . . . . . 7] . . 1] . . . 1 . . . . . . . . . 1 . . dº ſº e © & 11| 1| 11 ...| 1 || 1 || 10 1|Death from other injuries. 2 . . . 2 . . . . . . . . . 2 . . [fracture of skull. 1] . . . . . . . 1| 1| . . . . . Also comp., compl., comminuted. 24. 2 22 1| 3| 3 22 1|Other injuries complicating, 3. 15 . . 1; 1| 1 || 1 1; ..|Other injuries complicating, 1. 21| 3 2 1 13| 19| 3| 2 tº e e wº & 82 9 52| 31|| 5 || 3 50 38|Other injuries complicating, 3. 6|| 1 || 6 ...| 1 || 1 || 6 ...|Other injuries complicating, 1. 4| 1| 5 | . . . . . . . . 5! . . & © g e º 15| . . 3| . . | 12| 12| 3| . . 15| . . . 13| 1 || 1 || 1 || 13| 1 4] ...| 1 | . . 3| 3| 1 | . . 1] . . . . . . . . . 1] 1 . . . . . gº * & © & 65 7| 60 10] 2 2. 59 11|Other injuries complicating, 2. 1] . . . . . . . . . 1 1 . . . . . tº * & º Scapula: Body 25 4. 23 3| 2: 2 23 4|Other injuries complicating, 2. Coracoid process 1| . . 1] . . . . ..] 1 . . * & ſº º * Acromion process. 6| . . 6] . . . . . 5| 1 tº e * e © Humerus: Simple 50 13 52 6 5) 5 51] '7|Other injuries complicating, 5. Compound . e g 15 4 14 ..] 5 6' 13 ... Other injuries complicating, 2. Internal complications . * 1| 1 | 11| . . . . . . . . . 11] . & e g & º Comp, compl. and commi’d. . . . 11| 11 . . . . . . . . . 11] . . & & wº te * Radius: Simple 82] 21| 91| 7 12 11| 85| 7|Other injuries complicating, 11. Compound 9| 1| 7| 2 1 1| 7| 2 |Other injuries complicating, 1. Greenstick 1, 1] 2 . . . . . . . . . 2 . . c * º te gº Ulna ; Simple 27| 5 30 1 1, 1] 30 1|Other injuries complicating, 1. Compound . wº e t 5| 1 || 5 ... 1 1 4 1|Also fracture of skull, 1. Olecranon process: Simple . 5|| 1 || 5 ...| 1 || 1 || 5 ...|Fracture of skull, 1. Compound g º 2| 1 || 2 ...| 1 || 1 || 2 ...|Died from senility and other injuries. Radius and ulna: Simple. 16| 5 19 . . 2, 2, 19 ...|Other injuries complicating, 2. Compound . º e ſº 7| 6 6 . . 3| 3| 6 . . Other injuries complicating, 2. Comp., compl. and commi’d. 1| 3| 3| 1 | . . . . . 3| 1 tº tº & e g Femur. Simple e 49 19 46 12 10| 9 47| 12|Other injuries complicating, 8. Compound 10 ..] 5 .. 5 5| 5 ..|Other injuries complicating, 2. Multiple * 2 . . . 1] . 1| 1 || 1 ..|Other injuries complicating, 1. Trochanter major . 2] . . . 2 . . . . . . . . . 2 .. tº sº e ę tº Intra-capsular 9| 8 || 6 11 . . . 6] 11 © e ge & wº Patellae: Simple 12| 3| 12 2. 1 1| 13 1|Other injuries complicating, 1. Compound 3] . . . 3. . . . . . . . . . 3] . . e § & © e Tibia ; Simple . 57| 8 43| 20 2. 2 40 23|Other injuries complicating, 2. Compound 36] 2 24 12. 2. 2 25 11|Other injuries complicating, 2. Fibula: Simple 43| 11| 43| 11| . . . . . 34| 20 tº & t g & Comminuted 4| . . ; 3. 1] . . . . . | 3| 1 & * > * > e & Compound . 13 2 11 . . 4. 4. 11 ...|Other injuries complicating, 4. Pott's : Simple 42|| 5 || 35| 12 . . . . . 32 15 & iº e Compound º e 2 . . . 2 . . . . . . . . . 2 . . g º e tº e Tibia and Fibula : Simple 48| 12 29, 28 3| 3| 29| 28|Other injuries complicating, 3. Compound © & 48 6. 29, 13 12 12| 29| 13|Other injuries complicating, 7. Total 1045, 197; 871. 193| 178] 190| 838. 214 58 NEW YORK STATE MEDICAL ASSOCIATION. DISCUSSION. DR. E. M. MooRE, of Monroe county, said he had made some experi- ments upon the cadaver, and had undertaken to create dislocations of the ankle-joint, watching carefully the steps by which these fractures were produced, and the character of the dislocation ; and he had found, as stated in the paper, that the external malleolus is apt to be the first to give way. If one conducted the experiments slowly, one could see the bone pulled apart because of the superior strength of the ligaments. In these experi- ments, made many years ago on the cadaver, in the course of study on Colles’ fracture, he found that the ligaments attached to the styloid process. were stronger than the styloid process itself, so that this process would be completely pulled off. Ruptures of the ligament did occur occasionally without fracture of the bone, but the rule is, that the bone yields first. He had always used Dupuytren’s simple splint on the inside, with the limb slightly twisted around, provided it did not disturb the separation of the internal malleolus. He had always carefully watched for fracture of the internal malleolus, and had frequently found it, but not always. In case of fracture of the internal malleolus, along with fracture of the fibula, if the internal malleolus be not pressed out by twisting the astragalus a little too far, which Dupuytren’s splint is apt to do, the result is perfect. Everyone must be aware that there is a tendency on the part of the frac- tured end to turn outward toward the tibia; this is easily obviated by bringing the line of fracture so that the inferior end will be drawn out to its full extent. According to his observation, when there is fracture of bones held together by an interosseous ligament, there is always a tendency on the part of the fractured ends to bend in to the opposite bone. This is So in the forearm, and in the tibia may even go so far as to spread the ankle-joint, and produce deformity. His rule was, to bring the lower fragment out, and allow it always to slightly overlap the upper fragment. If you turn it too much, there will be a displacement of the internal malleolus, but the padding applied to the internal malleolus, against which you draw, is very apt to keep it in place. In carefully imitating Dupuy- tren, we are not likely to go very far astray. If, however, the fracture at the internal malleolus were very movable, he used a pasteboard splint on each side, with pads on the side of the splint, in order to keep them in place. The author emphasised very properly the great difficulty experi- enced when there is splitting of the tibia, allowing a very material dis- placement of the astragalus, and also necessitating a relaxation of the tendo Achillis, and the tendency there is, as a matter of course, for the foot to be pulled forward. If anchylosis occurs in that position, the entire usefulness of the foot is destroyed. His own practice has been to combine the two ideas, viz.: he desired to carry out Dupuytren’s idea, and also to Secure relaxation of the tendo Achillis, and make some traction. Accord- ingly, he used the double inclined plane, fastening the foot to the foot- board, and turning it a little upon itself, to produce Dupuytren's twist, thereby relaxing the muscles. By making traction on the foot, and draw- I) ISO/USSION. 59. ing it down, the strain is taken off from the movable fragment, and We can then put a pad on the inside to push the fragments together. In this Way, we accomplish everything desirable in the treatment of Colles' fracture. He had not met with the difficulty, and with the bad results, which the text-books speak of in connection with this fracture, and he had never had a case of anchylosis following the treatment just outlined. There is always a certain amount of stiffness wherever there is inflammation, but this all passes off after use. Briefly, then, the treatment consists in putting the foot right, holding it there, drawing sufficiently upon it to Counteract the action of the muscles, and securing perfect adjustment by means of pads, and if necessary, by the use of ether, motion, and massage. He did not agree at all with Dr. Manley in respect to Colles’ fracture. If any one does not have good results in Colles’ fracture, it is because he is not up to the times—but more of this in his paper to-morrow. DR. MANLEY, in closing the discussion, said that he felt very thankful to Dr. Moore for his criticism of his paper, and he fully agreed with the line of procedure which Dr. Moore had considered the ideal one. He would add, that this treatment was applicable to any other fracture of the leg, accompanied by much displacement, as the fundamental feature of this method was relaxation. In the typical Colles' fracture, not only in his own experience, but in that of the very best surgeons, so far as he knew, the results were not satisfactory. Even the distinguished author on fractures, Dr. Frank H. Hamilton, did not escape deformity after receiv- ing a Colles’ fracture. MUSCULAR TRACTION FOR, HIP-JOINT DISEASE. By THOMAS M. LUDLow CHRYSTIE, M. D., of New York County. (Read by title November 15, 1892.) Clinical study of the effect of traction in the treatment Of hip-joint disease will demonstrate two facts: 1st. That the force of traction is exerted entirely upon the muscles of the thigh, and not upon the articular structure of the hip-joint; and 2d. That when firm and efficient counter-traction, Or counter-resistance to traction, is furnished, there is no need of any lateral or abducting force. By traction is meant the pulling of the limb in a direc- tion from the hip-joint, and in a line with the position held by the thigh in reference to the median line of the body. Any lateral or abducting force used in connection therewith, diminishes the force of the traction proper, and interferes with the object in view. This object is, briefly stated, the stretching of the muscles until they have lost their tone, and are, in fact, so temporarily paralysed that they are unable to take on the spasmodic contractions which are the peculiar feature, and chief cause of hip-joint disease. Furthermore, when this con- dition is attained, there can exist the rest and quiet which permit the subsidence of the inflammation in and about the hip-joint. Traction has now been in use, and growing in favor for over a quarter of a century, but there has been, and is a widespread notion that its effect is exerted, either to pull or hold apart the Opposing articular surfaces, or to keep them from coming together with any degree of pressure. Aside from the fact that such a theory cannot be verified by clinical observation, it leads to a very in- MUSOULAR TRACTION FOR HIP-JOINT DISEASE. 61 efficient use of traction. With such view, the grasping of the limb anywhere on the digital side of the hip is deemed sufficient, with the result that the grasp is rare- ly placed above the lower third of the thigh ; indeed often only the foot or leg is grasped, and the muscular part, the upper two-thirds of the thigh, is entirely neg- lected, though this is the very part which most needs attention. Whether it be true that the inflammation of the hip- joint acts as a reflex stimulus to muscular spasm, or the muscular spasm, as the cause of the hip-joint disease, is due to some neurosis, it is certain that this spasmodic muscular action is the chief symptom to be treated. The theory that phimosis is a potent cause of hip-joint dis- ease, by exciting these muscular spasms, shows the prominence the latter occupy in the aetiology of this disease. It may even be stated, that the present system of preventing the weight of the body from coming upon the affected limb, is a plan to relieve the limb from mus- cular action, rather than to preserve the hip-joint from concussion.* It has been held that the muscular spasm is of the nature of swimmer’s cramp, where relief is obtained by tightly constricting, as well as pulling the affected mus- cular tissues. I have found this, to a great extent, true. For the purpose of grasping the muscles of the thigh, I apply the adhesive straps on the inner side of the thigh, as high as the crotch, and On its Outer side to the trochanter; the retaining roller bandage is carried high enough to cover the adhesive straps, and often includes the pelvis to prevent slipping. The rest of the limb is grasped low down—to within an inch of the ankle. The constriction of the muscular upper part of the thigh is as efficient in securing comfort to the patient, as is the traction, and the object of both is to secure control of the muscles of the thigh. The apparatus used to exert * Rationale of Permanent Dressings. Prof. A. B. Crosby, Med. Record, N. Y., Sept., 1873. 62 WEW YORK STATE MEDICAL ASSOCIATION. the traction force may be the weight and pulley, or some of the numerous means of employing the ratchet- bar, all of which must be familiar objects to the surgeon. As the sole purpose of this article is to draw attention to the importance of considering traction as muscular, and not articular, the consideration of apparatus is omitted, except the statement that the splint, reaching underneath the foot, in order to take adhesive straps from both sides of the limb for its entire length, may, for that reason, be considered the most efficient. Counter-traction is of course arranged on the proximal side of the hip-joint ; but the construction of the pelvis places it on a level with the digital side, thus obscur- ing its mechanical relations to the traction. For this reason, they have not been so clearly studied as they should be. Very often a good form of traction is of no service because of inefficient counter-traction. The ef- fect of traction is then deceptive, and ingenious devices are resorted to in order to increase its efficacy ; but all to no purpose so long as the defect in the counter-trac- tion is unremedied. With apparatus, the counter-trac- tion is ordinarily obtained by padded straps passing either side of the perinaeum. These straps are generally round, in order to pass between the thigh, and the scrotum or vulva, but on account of their shape, they often press upon the sciatic until it is unendurable. This can be remedied without diminishing the counter- traction, by flattening it behind, and having it terminate in two straps, in order to distribute the pressure over a greater surface. They are best made out of strong web- bing, covered with a roll of woolen goods sewed at each end to the webbing, this covered with a layer or two of flax (not cotton) lint, and the whole covered with Surah or China silk. These straps must be watched, and promptly renewed before they are worn out. The skin receiving the counter-traction, must be carefully wiped clean daily with alcohol, or alcohol and tannin. The counter-traction is defeated by a yielding of any MUSOULAR TRACTION FOR HIP-JOINT DISEASE. 63 part of the apparatus. By attention to such points, I have found very much less force needed to overpower muscular spasm, than where the resistance is uncertain and unsteady. When using the weight and pulley, rais- ing the foot of the bed to procure counter-traction, is useless during the attacks of strong muscular spasm which at times occur. The pelvis must be secured to the head of the bed, and the affected limb raised so as to swing clear of the bed. During the spasmodic attacks, a box may be so placed that the patient can brace the foot of the well limb against it while the weight is in- creased to an adequate degree. I have in this manner occasionally used fifty pounds with great effect. The pulley should be not less than five inches in diameter. Every case differs as to its needs, and its management involves an infinite variety of details, but all with a view to securing firmness and precision in both traction, and its accompanying force, counter-traction. SOME RECENT CASES OF APPENDICITIS. |By NATHAN JACOBSON, M. D., of Onondaga County. November 15, 1892. In presenting a few cases of appendicitis, which it has been my fortune to see recently, it is not my purpose to consider in detail this most important pathological con- dition ; nor can I hope to place before this Association any facts which may be new. My object is rather to add my observations to existing data, for out of the accumu- lated experience of all, must be developed the true pathology and treatment of appendicular disease. With the presentation of the result of his investiga- tions into the pathology of the appendix, to the Associa- tion of American Physicians, in 1886, Fitz established a new era in our knowledge of these conditions. Since Morton, in the spring of 1887, deliberately cut down upon, and successfully removed an ulcerated appendix, and the equally successful undertaking of Sands at the close of the same year, the surgical treatment of the diseased appendix has been completely changed. The subdivision of appendicitis into many forms, only serves to obscure a proper conception of the condition, and renders more difficult a decision as to the proper treatment. In a large number of cases, inflammation of the Vermiform process is of a catarrhal type, terminating without suppuration. It is not easy to determine, with mathematical accuracy, what percentage of cases belong to this class, but it has been stated to be as high as eighty, or even ninety-five per cent. This large group comprises those to be treated by medicinal measures. The very fact that such a large number of cases is quite certain to recover in the hands of the physician, makes it all the more necessary that he should be on his guard RECENT CASES OF APPENDICITIS. 65 not to include amongst them a single case which might ultimately demand surgical treatment. To determine which cases are to be treated medicinally, and which surgically, will often tax the ingenuity and skill of the physician. I shall deal in this paper only with such cases as require surgical measures. To this class belong, first of all, cases in which the inflammation reaches the suppurative stage. As types of the Suppurating form, not involving the peritonaeal cavity, I desire to refer briefly to two cases. CASE I. On the 29th of January of the current year, I was requested by Dr. Breese, of Syracuse, to see with him a man, forty-one years of age, a machinist, who gave a negative family history. Twenty-five years pre- viously, he had had typhoid fever, and five years later, small-pox. He stated that he had had numerous “bilious attacks,” which were always preceded by pain in the right iliac fossa, severe enough to make walking difficult. This pain would increase in intensity until it prostrated him ; then nausea, and fermentation of food in the stomach would occur, and he . would be ultimately relieved by free emesis, and evacuation of the bowels. He recalled having had, twenty years previously, a tumor form in the right iliac region, which ultimately disappeared. On January 1, 1892, the pain returned, but he kept about until the 16th of the month, each day finding walking much more difficult, and the pain more severe. A tumor, steadily increasing in size, appeared in the right iliac fossa during the two weeks preceding my visit to him. There was constant fever, anorexia, and nausea, but no vomiting ; the bowels moved once daily. I found tume- faction reaching well down to Poupart's ligament, upwards as high as the level of the umbilicus, and internally for a distance of three inches. Rectal examination revealed the presence of a tumor. His hygienic sur- roundings were very poor, and the prospect of care at home no better. He was therefore sent to St. Joseph's Hospital on the following day. Upon his arrival, we found that during the preceding night there had been a spontaneous rupture of the abscess into the rectum, and all evidence of tumor had disappeared. Pus was discharged for five days, after which his local and general condition constantly improved, and he left the hospital on the 18th of February, thoroughly well. The statement is usually made, that recurrent forms of appendicitis rarely lead to suppuration. This is evidently not the universal rule; for I take it, we are Obliged to regard his so-called “bilious attacks” as manifestations of appendicular inflammation. It has been recently said that rectal examination is very valu- 5 66 MEW YORK STATE MEDICAL ASSOCIATION. able, in determining at an early period the presence of disease of the appendix. For myself, I have only encount- ered it very late. Lange, and others, have operated upon this variety of abscess, which the Germans prefer to call “paratyphlitis,” by incision through the rectum, with, as a rule, a successful issue. CASE II. H. C. H., thirty-eight years of age, was seen in consultation with Dr. J. L. Heffron, July 14, 1892. During the past winter, he had been Seriously ill with typhoid fever, from which he seemed to have made a very satisfactory recovery. At various times during the past few years, he had had attacks of severe pain in the right side of the abdomen, associated with nausea and constipation. Nine days prior to my visit, he had been seized with a severe pain in the bowels, well down in the right inguinal region. The bowels were moved daily, by administering one drachm of Rochelle Salts each morning, and tympanites was controlled by intestinal antiseptics. Hot applications not only failed to relieve the pain, but were irksome to him. The temperature had not been elevated, although at my visit it reached 102° F. The pulse had usually been about 80. His pain was not at all severe, and he did not really feel very sick. After the fifth day, a tumor could be mapped out, reaching along the brim of the pelvis, from the anterior superior spinous process, downwards three or four inches. It was very firm, did not fluctuate, and was not at all tender. Neither the condition of the patient, nor of the tumor, seemed to demand active interference. I did not see him again until November 22d. There had been a daily rise of temperature. The thigh was drawn upwards, and rotated inwards; the tumor had grown rapidly in size, was very tense—in fact too tense to permit the recognition of fluctuation. Immediate operation was advised, and under ether, the abscess was freely opened by an incision running one inclabove, and parallel to Poupart's ligament from its outer third up to the anterior superior spinous process. In carrying the incision deeply, the peritonaeum was incised for the dis- tance of an inch, the omentum protruding. This was speedily closed with catgut suture. It was estimated that nearly a pint of pus was discharged. The wound was thoroughly irrigated and packed with iodoform gauze. Daily irrigation with a sublimate solution, and packing with iodoform gauze was kept up. The closure of the wound has been very slow, and in fact at this late day there still remains an unhealed sinus, about one and a half inches deep, and one-quarter of an inch broad. The general health of the patient has steadily improved, but mentally he is greatly depressed because of his tedious convalescence. This case is another example of suppuration occurring in a chronic relapsing appendicitis. The vermiform pro- cess probably had melted away in the course of the RECENT CASES OF APPENDICITIS. 67 suppurating inflammation. The abscess cavity, with its thickened walls, evidently stood in the way of prompt repair, and subjected the patient to the annoyance of very tardy recovery, and the possibility of a permanent sinus. CASE III. As very strikingly opposed to the slowly forming pus collections which are hemmed in by adhesions, and from which the peri- tonaeum is thus protected, I desire to report the history of a patient, seen with Drs. Elsner and Didama, October 3, 1891. He was unmarried; twenty- three years of age; a candle-maker. He was very vigorous, and had not required medical attendance since childhood. On the morning of October 2d, he had gone to his work as usual, but at ten o'clock called upon Dr. Elsner, complaining of pain in the bowels. Upon examination, the abdo- men was found to be distended, rigid, painful on pressure, particularly so at the “McBurney point,”—two inches from the anterior superior spinous process, on a line drawn to the umbilicus. It was learned later, that on the preceding day he had been obliged to return home from his work be. cause of abdominal pain, but finding relief from medicines administered at home, he resumed work. When first seen by Dr. Elsner, the temper- ature was normal, but the diagnosis of appendicitis was made. Within twenty-four hours the condition was greatly aggravated. There was con- stipation, increasing pain, some vomiting, general peritonitis, temper- ature 102.5°, pulse 96. In the afternoon, when seen by me, in company with the physicians mentioned, it was decided to do a laparotomy. The patient was properly prepared with the usual antiseptic precautions. An incision along the outer border of the right rectus abdominis muscle was then made. There was but little bleeding. Upon incising the peri- tonaeum, thick yellow pus appeared. The wound was enlarged, and the caecum exposed. Upon its surface were thick, adherent flakes of pus; the omentum was not gangrenous, the peritonaeum was thickened, and there was some pus in the iliac fossa. The appendix was reached without difficulty, and was found lying to the outer side of the caecum, and adherent to the surrounding tissues, but it was easily separated. It was thickly infiltrated, darkly discolored, and upon its free extremity pre- sented a gangrenous ulceration. There was no perforation, and it did not Contain any concretion. It was one and three-quarter inches long. After ligation, it was cut off, its cut surface cauterised with concentrated car- bolic acid, the diseased surfaces touched with a strong sublimate solution, a drainage tube inserted, with a packing of iodoform gauze around it, and the wound partially closed. After the operation the pulse was 130. At 10 P. M. the patient was resting quietly, but the pulse had gone up to 150, the respirations to 32, and the temperature to 102.8°. The patient had not urinated voluntarily during the entire day. The following morning the nurse reported that the patient had passed a quiet night. At 10 A. M. the temperature was 102.8°, pulse 130, respirations 30. At 3 P. M. a marked change suddenly came over him; the temperature shot up to 105.5°, and 68 NEW YORK STATE MEDICAL ASSOCIATION, the pulse to 160; his respirations became shallow, and there was mutter- ing delirium with great depression. When seen by me at 6 P. M., he was unconscious, and the pulse flickering ; an hour later, he was dead. This very rapid development of ulcerative appendici- tis, awakening, almost from the start, a septic peritonitis, without any previous manifestations of disease of the vermiform appendix, is very unusual. That a person should have continued his work after a peritonaeal in- flammation had developed, and not presented himself to a physician for treatment, hardly seems possible. The period at which an operation is performed is not to be designated as “early,” because only a few hours, or even days have elapsed since the treatment was begun ; this period cannot be measured by any length of time. An “early” operation is one done while the disease in- volves only the appendix. If peritonitis is present, it matters little whether it has required one hour, or one week for its development. The complication is equally serious in either event, and the operation, no matter how soon performed after the appearance of septic periton- itis, is no longer to be regarded as an early operation. Dr. Jacobi has made a very happy suggestion, namely, that an operation, to be successful, must be not only early, but timely. Very few cases have recovered, in which septic peritonitis has co-existed. Recently, how- ever, Abbé has secured the successful termination of some of his cases, by making a second incision upon the left side of the abdomen, and in this way establishing thorough irrigation. CASE IV. I was called by Dr. E. A. Didama to Cortland, N. Y., Feb- ruary 10, 1892, to see a young man twenty-seven years of age. He had never been seriously sick, but for several months, upon exertion, had complained of a “pain under the ribs" on the right side. There never had been an acute attack of pain or fever. He had felt as well as usual until the morning of the 8th, when he was seized with such severe pain in the epigastrium as to oblige him to leave his work. There were slight elevation of temperature, great pain, and constipation. An anodyne was administered. On the following day the pain was intensified, and it was necessary to administer morphine hypodermically. On this day vomiting RECENT' OASES OF APPENDIOITIS. 69 set in ; on the 10th the symptoms were all aggravated, and the pain local- ised in the right side, and he was unable to retain either food or medicine administered by the mouth. Under the influence of a mercurial cathartic, the bowels moved loosely several times. One movement in the afternoon, which contained solid faecal matter, relieved the patient considerably. At 1 P. M. the temperature was 102.5°, and the pulse 102. When seen by me at 3 o'clock the temperature was 101° F., pulse 110, respirations rapid and shallow ; both limbs were extended, and the patient moved about in bed with great pain. The entire iliac region was exceedingly sensitive to the touch, and the abdomen slightly distended. Along the outer border of the iliac fossa dullness existed for a space one inch in breadth ; no tumor could be felt. The most tender point was one and one- half inches from the anterior superior spinous process, on a line to the umbilicus. The patient felt somewhat improved, but the persistence of the local signs led me to advise laparotomy. Assisted by Drs. Didama and Higgins, of Cortland, after a hasty preparation of the patient, I made an incision four inches in length, along the right linea semilunaris. Upon incising the peritonaeum, a stream of thin pus appeared. The appendix did not readily come into sight, but was discovered by my finger, external to, and behind the caecum, extending upwards, and adherent throughout its entire length. It was greatly thickened and infiltrated, purple at its terminal extremity, and gangrenous near its attachment to the caecum, for a distance of one and one-half inches. With some difficulty it was de- tached, and dissected well down to the caecum. The parts were sponged out with an antiseptic solution, the intestines protected with sponges; the appendix drawn up, ligated with silk at its base, and after tying its mesentery, removed. The cut end was cauterised with carbolic acid, the cavity was thoroughly mopped with sublimate solution, 1 to 1000, a drain- age tube introduced, surrounded with a packing of iodoform gauze, and the wound partially closed at its upper extremity. The patient rallied promptly from the operation, and two hours later the temperature was 98.5°, pulse 78. He slept fairly well during the night. A change of dressings was made early next morning. He still remained free from fever, and though suffering at the time of dressing, was otherwise free from pain. The appendix was found to be six inches in length, distended With a quantity of thin pus, and contained no less than one dozen firm Concretions of faecal character. Word was received on the 13th of the patient's continued improvement, and the statement made that apparently nothing could interfere with his recovery. Shortly before 10 o'clock on the evening of the 15th, I received a message calling me immediately to Cortland. On this evening the patient had suddenly developed a rise of temperature, and great pain in the iliac fossa. The bowels had moved daily, and there had been substantially no discharge from the wound. Anaesthetising the patient, I made an examination of the wound, and found it rather adherent at its surface. Beneath the superficial adhesions there was a small quantity of pus, and on displacing the head of the colon a stream of liquid faeces appeared. Cleansing the wound as well as pos- 70 NEW YORK STATE MEDICAL ASSOCIATION. sible, an examination showed a perforation into the caecum, close to the appendicular attachment. Its edges were promptly denuded and inverted, and the wound closed with a Lembert suture. The patient rallied nicely from this operation, but gradually sank under the development of septic peritonitis, and died on the 20th of February. The very promising course of this case in the early days following the operation, had led us all to look for- ward, with apparently good reason, to a happy termina- tion; but despite the irrigation of the wound with antiseptic solutions, and the subsequent careful packing with iodoform gauze by Dr. Didama, the septic inflam- mation led to perforation of the caecum. CASE W. September 24, 1892, I was called by Dr. C. S. Roberts to see J. M., twenty-one years of age, a butcher, who was supposed to have a strangulated hernia. The patient was said to have a right indirectinguinal hernia, which he had been able to reduce whenever it protruded, by lying down and keeping quiet for a short time. On the evening of the 22d, he lifted a heavy quarter of beef, and was speedily seized with pain in the abdomen. During the night, the pains became very severe, and were restricted to the region of the umbilicus. On the morning of the 23d, he was given two large doses of “salts.” His bowels had moved on the pre- vious day, but did not respond to the salines. The pains increased in severity, and Dr. Roberts, being called, administered an opiate, without relief. A soft, elastic tumor existed in the upper portion of the right side of the scrotum. Taxis was applied, and also heat, but ineffectually. The patient was put upon his back, with thighs elevated, and resting upon a chair. In this position I found him at 4 P. M., on the 24th of September. Examination of the tumor revealed an elastic swelling the size of a small hen's egg. Above and below it, the spermatic cord could be felt. The abdomen was not distended, but was exceedingly rigid ; the tongue had a broad, brown central streak; the pulse was 80, and the temperature 100.5°. The entire abdomen was tender to pressure, but the pain was par- ticularly on the right side, and tenderness to the digital pressure was most marked at the “McBurney point.” The opinion was expressed, that whatever the Swelling in the scrotum might be, it had nothing to do with the abdominal trouble, which was believed to be a beginning general peritonitis, dependent upon appendicitis. Laparotomy was advised, and, assisted by Drs. Roberts and H. D. Didama, was undertaken in the usual way. The incision was made along the outer border of the rectus abdom- inis muscle. After controlling the haemorrhage, which was slight, the peritonaeum was opened, but no pus was found. The appendix was con- cealed in a mass of adhesions. From these it was carefully separated, and was found to be about one and one-half inches in length, thickened, almost purple in Color, its surface in a condition of gangrenous inflammation. RECENT CASES OF APPENDIOITIS. 71 Near its base it was constricted and bent upon itself. It was ligated at its base, cut off, and its cut end cauterised with carbolic acid. Every part was carefully washed, and, as there had been no pus present, the wound was closed by suture. It was now thought advisable to investigate the character of the scrotal swelling. An incision over it soon exposed an encysted hydrocele of the cord. This was split open, stitched to the sur- rounding skin, and packed with iodoform gauze. In the evening, the urine, which had been retained for twenty-four hours, was drawn with a catheter. He passed a very restless night, but suffered more from the cystic, than the abdominal operation. On the following day, the temperature reached 101.5°, but his tongue was less dry, and the abdomen less tender. There was no vomiting; the bowels remained constipated. By the 28th of September, all evidence of peri- tonaeal inflammation had disappeared, and from this time, the patient made an uninterrupted recovery. In this case, the timely removal of an appendix, begin- ning to be gangrenous, arrested peritonaealinflammation, and resulted in a very happy recovery, where I believe a delay of twenty-four hours would have placed the patient beyond operative relief. CASE WI. C. W., forty years of age ; married; seen September 9, 1891. He had usually enjoyed good health, but early in May last, while at Bald- winsville, he was seized with pain in the right side of the abdomen, accom- panied by nausea, fever, and constipation; and he was confined to his bed one week. During the latter part of July, a similar attack confined him to his room for a few days. Two days ago, the third recurrence manifested itself. During the months which had intervened, there had been more or less constantly present, a tender spot on the right side of his abdomen, which frequently interfered with locomotion. An examination showed a very slight tumor. Tenderness to finger pressure was marked at the “McBurney point.” There was persistent nausea, but no vomiting. During the following week the patient was kept abed, although the acute manifestations disappeared about the 14th of the month. All that remained Was a slight dullness along the outer border of the iliac fossa, and a little induration just above the level of the anterior superior spinous pro- Cess. The patient, who had become greatly depressed because of the three recurrences of inflammation of the vermiform appendix, in the course of four months, very readily consented to the suggestion, that because of the persistence of the disturbance, the appendix ought to be removed. On September 20, 1891, he was removed to St. Joseph's Hospital, Syracuse, and on the following day, assisted by some of the gentlemen of the hospi- tal staff, after the usual preparations, I made an incision into the abdom- inal cavity, as heretofore described, and after a little difficulty, discovered the appendix adherent on all sides to the outer and posterior portion of the caecum. It was one and three-quarter inches in length, densely infil- 72 NEW YORK STATE MEDICAL ASSOOIATION. trated, and constricted at its base. Protecting the peritonacal cavity with Sponges, the vermiform process was removed with a knife, and its base cauterised with the Paquelin cautery. The abdominal wound was closed. There was nothing to mar the patient's recovery, which proceeded in every way satisfactorily. In the fourteen months which have elapsed since the operation, the patient has not had the slightest suggestion of a return of his former symptoms, and has improved so much in his general condition, that, to use his own words, “he feels quite like a new being.” The cases presented form an excellent text for the dis- cussion of the surgical treatment of appendicitis, inas- much as they present the various surgical aspects of the disease. But as I have already occupied so much time, I prefer to briefly summarise the propositions I have to offer, and put them in the form of a series of conclusions, based not only upon my own cases, but upon the accu- mulated experience now at the disposal of the profes- SIOIl. OONOLUSIONS. 1. As the appendix, and not the caecum is the primary seat of disease, these forms of inflammation should be known as appendicitis. The terms typhlitis, perity- phlitis, and paratyphlitis, are not only confusing, but incorrect. 2. It is most important to determine whether the inflam- mation is non-Suppurative or Suppurative. If Suppura- tive, it is equally vital, for proper treatment, to establish whether the diseased appendix and the purulent collec- tions are to be hemmed in by protective adhesions, or to remain in direct communication with the general perito- naeal cavity. 3. With symptoms of moderate severity, and no ten- dency of the inflammation to increase in extent or intens- ity, but rather to decrease after thirty-six hours, it is Safe to treat the case medicinally. 4. The exhibition of salines or other cathartics in the early stage of an appendicitis, is not only inadvisable, but apt to interfere with the development of protective adhesions, and may even be responsible for perforations. IRECENT CASES OF APPENDIOITIS. 73 Exploration with the needle to determine the presence of pus, is useless, and may be dangerous. 5. The violence of the symptoms, and their continu- ance, and progression, indicate the presence of existing suppuration, and render operative interference justifia- ble. The earliest manifestations of a developing general peritonitis make immediate operation absolutely impera- tive. 6. Each case is to be considered in the light of the in- dividual symptoms it presents. The absence of fever is not to lull the medical attendant into a belief of security. The proper moment for operative intervention in a given case cannot be established by the period of time elaps- ing since its development. Timely operation implies its performance before the appearance of septic peritonitis, or other serious complications. 7. Where the inflammatory process is of moderate severity, and evidence of tumor formation is present, operation can be delayed until the fifth, or even as late as the twelfth day. The incision then to be made, is to begin parallel with Poupart's ligament, an inch above its centre, and curve upwards along the outer border of the iliac fossa, and is thus to be made entirely extra-perito- naeal. 8. Acute cases, manifesting signs of perforation or gangrene, with no evidence of protective adhesions, de- mand immediate operation, the incision to be carried along the outer border of the rectus abdominis muscle, and directly into the free peritonaeal cavity. 9. Advanced cases of suppuration, in which the ab- Scess is post-caecal, can be opened by rectal incision. 10. Patients, in whom attacks of appendicitis persist- ently recur, especially when localised tenderness con- tinues, should submit to the removal of the appendix during an intermission. 74. NEW YORK STATE MEDICAL ASSOCIATION. DISCUSSION. DR. FRANK W. Ross, of Chemung county, said that the paper just pre- sented put the subject in the fairest way he had ever heard. He had paid some little attention to these cases during the past year, and he could recall one case of recurring appendicitis, where there were eight relapses within one year. The appendix was finally removed, and the patient made a good recovery. In another case, upon which he operated four months ago, the original attack was apparently one of general peritomitis. The trouble returned in one month, and during the next six weeks the patient remained in bed, but the tumor did not disappear from the iliac region. Several attempts were made to find pus, but none was found un- til about a week or ten days ago; then, on making the incision described by the author, an entirely extraperitoneal accumulation of pus was found, and evacuated. A large drainage tube was inserted, together with gauze packing. There has been no elevation of temperature, and the patient is now doing extremely well. Last week he had a case in which an abscess pointed posteriorly. He had thought it was possibly an abscess of the liver, but at the autopsy it was found to be a case of appendicitis, the appendix being bent backward and situated behind the caecum, and difficult to find. A large number of cases of appendicitis recover without surgical interfer- ence, and many physicians oppose operation on the ground that ninety per cent. recover without such a procedure ; but they allow the ten per cent. to die. The subject had been so clearly presented in the paper that there should be no mistake in regard to what cases are, and what are not suit- able for operation. DR EDEN. W. DELPHEY, of New York county, said that five years ago he had seen a case of recurrent appendicitis, in which there had been from twelve to fifteen attacks. The patient was a married man, twenty-two years of age. When first seen by the speaker, he had been suddenly seized at two o'clock on that afternoon with such a severe pain in the right iliac fossa, that he was taken home in a carriage. He was suffering greatly, and there was nausea, but no vomiting. On examination, his abdomen was found to be distended and tympanitic ; there was dullness in the right iliac fossa, and marked tenderness over “McBurney’s point.” He was given hypodermically, fifteen minims of Magendie's solution, and chloro- form by inhalation during the paroxysms. During this time the propriety of operation was suggested, but the family physician replied, that one of his previous attacks had been more severe than this one. It was learned subsequently that he had given the patient teaspoonful doses of the deodor- ised tincture of opium, and had kept up the chloroform inhalations for awhile, and had then administered salines. The next morning he was much better, and thirty-six hours from the onset of the attack he was able to return to his work, and was apparently well. This is one of those cases in which the patient was exceedingly ill, yet recovered without operation. So serious did the attack seem to be, that the speaker said from his pre- vious experience with such cases, he expected a fatal termination. DISCUSSION. 75 DR. E. M. MooRE, of Monroe county, said that the paper was one of the clearest it had been his good fortune to hear, notwithstanding that papers on this theme had come up frequently during the past two years, before every medical society whose meetings he had attended. The mat- ter is clearing up slowly, but it is not yet entirely clear. The fact still remains, as already stated, that ninety per cent. recover without operation. He had seen these cases over and over again in years past, and had ex- pected them to get well, and had seen them do so. This very year he had treated a case in which the symptoms were decidedly severe. There was great pain on the slightest touch, over what is called “McBurney’s point,” and for a considerable area around it. The temperature was 102°, and he had everything in readiness for an operation, but it was thought best to wait a little, as it was evening. The next morning he still hesitated, nor could he make up his mind on the following day, as the patient was no worse ; and then it was noticed that there was a slight change for the bet- ter. Slowly but surely the patient went on to complete recovery. One of the chief reasons for postponing operation in this case, was that he could not discover any dullness whatever on percussion. Although willing to admit that this is misleading on account of gas in the colon, causing more or less resonance, he had found it a valuable guide. Notwithstanding the light which had been thrown upon the subject to-day, he would still be at a loss to know when to operate, unless percussion showed flatness. No al- lusion had been made in the paper to the fact that these cases sometimes point in the loin. He had met with three undoubted cases of this kind. In One, which he saw for the first time at a late stage, stinking pus was found, which had given no evidence anteriorly of its existence. In another Case, which was opened in the loin and drained, the patient made a good recovery. In still another, the incision was made far to one side, near the antero-Superior spinous process of the ilium. He always made it a rule, therefore, to examine for tenderness upon the back, as well as on the front, The opening of these abscesses was not much more difficult than of other purulent accumulations. DR. JACOBSON, in closing the discussion, said that we were always con- fronted with the very difficult question of deciding which cases are Operative, and which are not operative. He had stated in his paper that from eighty to ninety-five per cent. were treated successfully by medicinal means, but it was none the less our duty in that other class, which demands Surgical treatment, to operate. The great practical point is, at what time is it our duty to operate 2 The presence of fever will not decide this ques- tion, for he had seen cases in which there was no rise of temperature. In One Case, Which he saw for the first time a few hours before death, the tem- perature had not been above 999 throughout the whole previous week of illness, yet all the local manifestations of suppurative peritonitis were present, with the general disturbance incident to septic infection. Regard. ing these abscesses forming in the loin, he said that when operation was Performed at a late stage, pus might be found at various points; he had 76 NEW YORK STATE MEDICAL ASSOCIATION. Seen it in the perivesical space, and in the caecum connecting with the ap- pendix. Those abscesses which pointed in the loin, he looked upon as retroperitonaeal, rather than purulent collections associated with appen- dicitis. He had recently seen such a case, in which the attending physician made a diagnosis of appendicitis, but the family refused their consent to an operation. The case seemed to him to be one of retroperitonaeal ab- scess. The patient passed into other hands, and at the autopsy, it was found that caries of the spine was responsible for the abscess, and that there was no appendicitis. Where there is no tumor, but violent fulmi- nating signs of a beginning peritomitis, one should operate without waiting for the presence of a tumor; but if there is no peritonaeal complication, one can afford to wait. The pulse will be found a more trustworthy guide than the temperature to the true condition present. The thermometer is altogether too frail a staff to lean upon in this class of cases. He could not understand how some advise postponing operation if the appendix be gangrenous and no protective adhesions formed, for the gangrenous appen- dix, like any other gangrenous part, should be removed, the only precau- tion being, to do this at a time when it is not likely to be followed by any Septic complication. The speaker said he would like to know the experi- ence of others in regard to the frequency of typhoid fever as a possible primary cause of inflammation in the appendix. ECTOPIC PREGINANCY. By HENRY D. INGRAHAM, M. D., of Erie County. November 15, 1892. Last December the writer was called in consultation to a neighboring city to see Miss L , nineteen years of age. He learned that for the past two years she had been a book-keeper in a large mercantile house ; her previous health had been good ; menstruation began at the age of sixteen, and had been normal except that on two or three occasions she had gone a week or two past her time. About four weeks before I saw her, she should have menstruated, but she got her feet and skirts wet, and the flow did not appear. Her mother then gave her some tansy tea. The flow soon came on, and it had con- tinued, except for a day or two at a time, ever since. Six weeks before I saw her, while at breakfast one morn- ing, she was suddenly seized with excruciating pain in the left inguinal region. She was faint, but did not lose consciousness, and there was nausea and slight vomit- ing, with chilliness, weakness, and dizziness. Her mother assisted her to a couch, where she lay during the fore- noon. In about an hour the pain was less severe, and the other symptoms gradually subsided, so that in the afternoon she felt so much better that she walked half a mile, and rode five miles in the street-cars, to see the family physician. He gave her some medicine, and the Second day after her visit, she was so much improved that she went to her work, one and one-half miles dis- tant, riding in the street-cars most of the way. She con- tinued to work until the fifth day, when she fainted at the store, and was taken home in a carriage. She re- mained at home three days, and again went to work. Four days later she again fainted, and was again taken home. 78 MEW YORK STATE MEDICAL ASSOOIATION. After that she did not go to work, but lay upon a couch the greater part of the time during the day. The ab- dominal pain gradually increased, and marked tender- ness developed. Her appetite failed, and nausea and vomiting occurred. At this time a very competent phy- sician was called. He ordered her to bed, gave morphine per rectum, and put hot applications to the abdomen, yet she continued to grow worse. Upon examination, he discovered a swelling in the left inguinal region, the na- ture of which was not clear to him, so he called in a gen- eral surgeon, who, I am told, thought the mass was con- nected in some way with the bowels, and was the cause of her constipation, which was so severe as to constitute almost obstruction of the bowels. He advised the re- moval of the patient to the hospital for an operation, but to this her parents would not consent. The patient continuing to grow worse, the writer was called, and first saw her about ten o’clock in the morn- ing. She was very anaemic, with a small, rapid, feeble pulse of 140 ; temperature 104°. There was excru- ciating pain in the abdomen, which was very tender, distended, and tympanitic. She had that peculiar, anx- ious expression, which is usually seen in the later stages of general peritonitis; there was frequent vomiting, and the bowels were constipated. She had slept but little for several nights previously. Owing to the extremely tender condition of the abdomen, it was difficult to ex- amine the patient satisfactorily, yet in the left inguinal region a large mass could be detected. Upon my sug- gestion, a thorough examination was made under chloro- form. The tumor was about the size of the foetal head, and semi-fluctuating. Waginal examination revealed the absence of the hymen, and a patulous OS ; from the uterus, which was crowded somewhat to the right, and measured three and one-fourth inches in depth, there was a slight, bloody, shreddy discharge. After completing the exam- ination, I remarked to the attending physician, that if the patient were a married woman, I would think it was EOTOPIO PREGINANCY, 79 a case of ectopic pregnancy, and that, at any rate, the proper treatment was an operation, but that it was very doubtful if the patient recovered, owing to the general peritonitis. My prognosis, but not my diagnosis, was made known to the family. They objected to the opera- tion unless they could be assured that the patient would recover. The following day a well-known gynaecologist was called in, and he advised an operation, but feared the result would be fatal. Without any urging or assurance of recovery from me, the parents concluded to have the Operation. Accordingly, the next morning, it was performed under ether, and with the most thor- ough antiseptic precautions. When the abdominal cav- ity was opened, the large mass in the left inguinal region was found enveloped by a very thin membrane, which broke down as soon as the attempt was made to lift it out. The mass of clotted blood and tissue was quickly removed, and the left tube ligated, and removed. The right tube and ovary were apparently healthy. The intestines, which were much distended with gas, were one mass of adhesions. It was necessary to draw off the gas from them in several places with the aspirator, in order to keep them within the abdominal cavity. The abdomen was carefully cleansed by Sponging, and the wound closed and dressed in the usual manner. The patient rallied from the operation, but died two days later from the peritonitis. The operation apparently had no effect in prolonging life, or in hastening the fatal termination. The tube was ruptured at the junction of the middle with the outer third. Although the debris was carefully examined, the foetus was not found, but the placenta was recognised under the microscope, thus definitely settling the diagnosis. CASE II. Last January, my colleague Prof. Mynter was called to see Mrs. D—, who being very ill, and not having the best surroundings at home, was taken to the Buffalo Hospital of the Sisters of Charity. Her history, as given in the hospital record, is as follows: She is an Ameri- Can, twenty-five years of age. Her previous health was good. She has 80 NEW YORK STATE MEDICAL ASSOCIATION. been married five years, and has one child, four years old ; no miscarriages. Menstruation began at the age of fourteen, and has always been normal. The last menstrual period occurred in the latter part of September, at which time the flow was normal. In October, she missed her period, and soon thought she was pregnant, as she began to have all the symptoms which she had observed in the earlier months of her previous pregnancy. A few days after the time she should have menstruated in November, and two months from the time when she did menstruate, she was seized, without any apparent cause, with a sudden and severe pain in the left inguinal region; so severe, that she fell to the floor in a faint. She was assisted into bed, and had remained there ever since, now six weeks. She began to flow, and so sent for the family physician, who told her she was having a miscarriage, For three or four days the flow was slight, then it stopped for two or three days, but began again more freely, and the discharge was shreddy and stringy. She was then told that the foetus had been expelled. Since then, there had been a very slight, and nearly continuous flow. When first seen, there was very marked abdominal distention and ten- derness, with severe pain, especially in the left side. She had chills, fever, night-sweats, vomiting, diarrhoea alternating with constipation, and fre- quent micturition. IIer pulse was 130, temperature 103.5° and respira- tions 30. She had becn treated first for threatened miscarriage, and then for miscarriage; the uterus had been curetted, and vaginal douches given ; and for the past four weeks she had been treated for peritonitis, with opiates, tincture of iodine, and hot fomentations to the abdomen, but without benefit. Examination revealed a symmetrical, but much distended and tender abdomen. The uterus was crowded forward so that the finger had to be passed up back of the pubis to feel the cervix ; the body could not be discerned. The vagina, posterior to the uterus, was very much distended, and there was apparently a fluid accumulation behind it. It was thought best to make an opening through the vault of the vagina, hoping to remove the cause of the trouble in this way. The patient was given an anaesthetic, and, with an aspirating needle, a thin, dark liquid was withdrawn. A small opening was then made with a knife, and after enlarging this with a uterine dilator, about three quarts of a thin, dark, stinking fluid gushed out. This fluid contained many solid particles, varying in size from a pea to a marble. The fluid was apparently mostly decomposed blood. You may have some idea of the foctid character of the discharge, when I say that the operation was performed in the presence of the senior class of Niagara University, and that nearly all the students left the room because of the stench. The cavity was washed out with a 1 to 4,000 bichloride solution, and two T-shaped rubber drainage tubes inserted. The abdominal disten- tion immediately disappeared, as did also the pain and vomiting; the fever was greatly diminished ; and the patient slept well the following night with very little opium. From that time on her recovery was steady and continuous. Three days later, one drainage tube was removed, and two days after this, the other tube. For a few days the cavity was packed FOTOPIO PREGNANOY. 81 with iodoform gauze, but it filled up very rapidly. There was but little discharge after the first day. The patient left the hospital perfectly well in a little over two weeks. I learned subsequently from the husband, that he had had gonorrhoea just before marriage, that for a long time he was troubled with gleet, and that two years ago he was operated upon for stricture; since then he had had no discharge. I have seen the patient several times since she left the hospital; she menstruates regularly, and is in perfect health. CASE III. Mrs. S--, twenty-five years of age, had enjoyed good health previously. She had been married four years, and had one child, three years old ; no miscarriages. Menstruation began at the age of seventeen, and has always been normal. Her last menstruation was on December 18th. On February 25th, Dr. Tobie was hurriedly summoned to see the patient, whom he found in collapse. She had been suddenly seized with intense pain in the left side, had fainted, and fallen to the floor. Warmth was applied to the body, and stimulants and morphine adminis- tered. For three days she had retention of urine, necessitating the use of the catheter. For about a month past, she has had, at different times, sharp pains in the left iliac fossa, but upon keeping quiet for a few minutes, they would stop. I was called by Dr. Tobie on March 3d to see the case with him. She was pale ; pulse 85, temperature normal, pain and tenderness in the left inguinal region. Waginal examination revealed the uterus crowded to the right, os patulous, a bloody, shreddy discharge from it, and a boggy mass to the left. From the history of the case and the examination of the patient, I agreed with the attending physician that it was a case of ectopic pregnancy with rupture into the left broad ligament, and probable death of the ovum. She was given one-sixth of a grain of morphine, when re- quired, and kept in bed. She gradually improved, but was confined to the bed nearly six weeks, and was not able to be around the house much for two months. Since then she has attended to her household duties, She menstruated normally on April 5th, and has been regular ever since. On November 1st, there was a small induration at the left, and posterior to the uterus, about the size of the first joint of the index finger; but there was no pain or tenderness. The patient says that for the past three or four months she has felt as well as ever. It might be said here, that there Was no secretion of milk in any of these cases when seen by me. These cases are reported, not because they present any very unusual symptoms, at least in their earlier stages, but for the purpose of putting them on record, and to aid in calling the attention of the general practitioner to the earlier symptoms of ectopic pregnancy. It is the significance of the earlier symptoms that should be heeded before it is too late to benefit the patient. There 6 82 WETV YORK STATE MEDICAL ASSOCIATION. is no doubt that ectopic gestation occurs much more frequently than is generally supposed, and unless the patient dies from haemorrhage or shock immediately following the rupture, nearly all can be saved if properly treated. I have now seen nine cases in which rupture had occurred, and all were operated upon except the first one I ever saw, who I believe might have been saved by an Operation, and the last one mentioned in this report, who did not need an operation, but recovered. My first case was seen before much was known in regard to this condition, but a post-mortem examination revealed the true state of affairs. The earlier symptoms of the first case reported to-day, are typical of ectopic pregnancy, except that usually the patient is not able to be up and attending to her work, as this one was for the greater part of the time for nearly two weeks after rupture oc- curred. The fact that this patient was an unmarried woman may possibly have thrown the attending physi- cian off his guard, but symptoms should always be in- terpreted as their significance demands, regardless of the condition of life. Although the patient claimed she had not missed her period until she had been ill about two weeks, and stoutly denied everything that would throw any light upon the subject, I believe she had missed the previous one, and that she had an idea that the suppres- sion of menstruation was in some way the cause of her illness. If I am correct in my supposition, rupture must have occurred at about the sixth week of pregnancy. There is not much doubt that the patient would have re- covered had the operation been performed sufficiently early, before general peritonitis occurred. Some may be inclined to doubt the diagnosis in the second and third cases. In the second case, there was a typical history of ectopic pregnancy with rupture into the abdominal cavity, the blood becoming encysted in Douglas's cul-de-sac. If a ruptured tubal pregnancy was not the cause of the accumulation of blood, what was ? Although her family physician and one or two EOTOPIO PREGINANCY, 83 consultants thought she had a miscarriage, there was nothing to indicate it except the slight discharge. All the evidence certainly points to ectopic pregnancy, and I am not aware of any other condition which could ac- count for all her symptoms. In the third case, the his- tory of ectopic pregnancy, with rupture of the tube into the broad ligament, and death of the ovum, was appar- ently very clear, and I think the result shows the cor- rectness of the diagnosis. f It will be observed that the first two cases mentioned had each been under the care of two or more physicians for several weeks, yet a correct diagnosis had not been made. In the last case, Dr. Tobie, to his credit be it said, made a correct diagnosis the first time he saw the patient, but not wishing to assume the entire responsi- bility, promptly called in counsel. The points which I wish particularly to emphasise are these : When a woman, whether married or single, skips one or more menstrual periods, and is suddenly seized with sharp, excruciating pain in the lower part of the abdomen, usually more marked on One side, grows faint, has nausea, or vomiting, is unable to sit up or walk, or walks with difficulty, has great tenderness on One side of the abdomen, and a shreddy, stringy, uterine discharge; and when, upon vaginal examination, a boggy mass is felt, generally at one side of and posterior to the uterus, it is time for the attending physician to call On a competent consultant, unless he feels perfectly able to manage a ruptured ectopic pregnancy. Even if all the above symptoms are not present, a consultation should be promptly called, as delay has cost many lives. When rupture occurs, abdominal section is the proper treatment, unless the rupture be within the folds of the broad ligament, when absorption usually takes place. Even then, when in doubt, operation is demanded. I believe the use of electricity in the treatment of this Condition is worse than useless—it is trifling with hu- man life. 84 NEW YORK STATE MEDICAL ASSOCIATION, DISCUSSION. DR. E. M. MooRE, of Monroe county, said that two months ago he had Operated upon a case of ectopic gestation, two and a half months after the cessation of menstruation. The patient was forty years old, had been married twenty years, and had never been pregnant, so that she had not the slightest suspicion of her condition. This is interesting in connection with what Mr. Bland Sutton has said about ectopic gestation being liable to occur in women who have long been sterile, and in fleshy women. She was seen by a physician in the neighborhood on July 8th. He found her suffering extreme pain, without any antecedent symptoms; there was marked pallor, and a small and rapid pulse; in other words, just such a con- dition as indicated a haemorrhage into the cavity of the peritonaeum. She Soon revived, and seemed to be quite comfortable, and there were then no evidences present of general peritonitis. On August 5th, and on the 12th of that month, she had similar attacks. It was at this time that the speaker was called in to see her. He operated, and found a ruptured extra- uterine pregnancy. The author had spoken about packing the cavity of the pelvis with iodoform gauze. He had found in this case that after tying off the tube, the mass, which was about the size of a large orange, was still adherent down in the iliac fossa. While separating the mass, the pelvic cavity suddenly became filled with blood ; the pelvis was immedi- ately stuffed full of iodoform gauze, and a drainage tube inserted. The haemorrhage was thoroughly and promptly controlled in this way. After the operation there was only a moderate rise of temperature and pulse. and at the end of the sixth day, the gauze and drainage tube were re- moved. About three weeks after, she developed an abscess, which was incised. He reported this case to show the facility with which we can stuff the pelvic cavity with iodoform gauze in such an emergency. DR. J. E. JANVRIN, of New York county, said that he had contributed during the past Seven years several articles on this subject, and he believed he was one of the first, if not the first in this country, to suggest the Operation of exploratary abdominal section in all cases in which the general Symptoms point to ectopic gestation. In all of his work in this direction since then, he had never had any occasion to alter his opinion. He believed with the author, that with the usual symptoms of pregnancy, which where often present, together with irregular menstruation and shreddy discharge, and the physical signs of some growth in the abdominal cavity, to one side or the other of the uterus, which is, as a rule, exquisitely Sensitive, the only justifiable procedure is to open the abdominal cavity. He had had the pleasure of expressing his opinion before this Association two years ago. The first two cases reported by the author were typical of an ordinary ruptured ectopic pregnancy, the third, of one down in the folds of the broad ligament, and the fourth, of one situated low down, and hemmed in by plastic exudation so that it could be opened through the vagina. The subject of ectopic pregnancy has been repeatedly discussed, and cases like I) ISO/USSION. 85 those presented in the paper were simply accumulative evidence. When the symptoms are such as to indicate to one of experience in this depart- ment of medicine, the probable existence of ectopic gestation, the use of any form of electricity is simply postponing a laparotomy. It is a condi- tion which should be dealt with promptly and thoroughly. We are cer- tainly justified in performing such an operation ten thousand times more than in a simple case of salpingitis, and yet no one hesitates in the latter class to operate. In the majority of cases, we shall find our diagnosis cor- rect, and even if the diagnosis be incorrect, such an exploratory incision will facilitate the subsequent management of the case. DR. E. M. MooRE, of Monroe county, remarked upon the fact, that in three of the cases reported in the paper, the pregnancy was on the left side, and asked Dr. Janvrin if this were the rule. DR. JANVRIN replied, that he had seen a number of cases occurring on the right side, and had not noticed that it was more frequent on one side than on the other. ANTISEPTIC VAGINAL AND INTRA_UTERINE INJECTIONS UNNECESSARY, IF NOT IN- JURIOUS IN THE DAILY PRACTICE OF OBSTETRICS. By DARWIN COLVIN, M. D., of Wayne County. (Read by title November 15, 1892.) I am well aware that it requires some courage to stand before this intelligent body of medical men, as an opponent of the practice of using antiseptic vaginal and intra-uterine injections in the every-day practice of midwifery. However, the extreme views which were so liberally paraded in the journals, but a short time since, are now seldom reiterated for want of conversions. The practice of frequent flushings of the vagina with antiseptic solutions when only normal processes are going On, during, and immediately after parturition, has begun its march, and is rapidly moving on to join that innumerable caravan of other ephemeral fashions which have preceded it. What good reason can the accoucheur give for introducing poisonous solutions upon mucous tissues, which are in a healthy condition ? Such conduct reminds me of a story of my boyhood: A stern parent was asked how he governed his boy. He replied, “I always punish him whenever I see him, for I know he has just come out of, or is just going into, mischief.” To make the application :-the accoucheur will punish with or without proper justification. I shall have nothing to say about antiseptic precautions in the various surgical procedures of the present day; it is only against the unnecessary, and oftentimes dangerous interference with normal physiological processes, that I desire to enter a protest. ANTISEPTIC INJECTIONS IN LABOR. 87 I will not consume your time in quoting authorities for or against my position, as they are all familiar to you, but I shall base my conclusions upon the results of more than two scores of years of constant obstetric practice, together with the care of between sixty and seventy cases since that branch of general practice has been largely abandoned. It has appeared to me when reading the various contributions of those who write so learnedly On the necessity of extreme antiseptic measures in partu- rition, that they fail to make use of a reasonable amount of what all practitioners should possess—good common SéIlS62. Do they ask themselves these very important ques- tions: Is the mortality of lying-in women any less by such means ? Is the death rate any less than it was fifty years ago º Assuredly they cannot reply in the affirma- tive. All advocates of that complete metamorphosis of the surroundings of the accoucheur and his patient, which are so ludicrously emphasised in their writings, cannot but be ignorant of the results obtained in the practice of midwifery half a century ago, when the percentage of recoveries was just as great as at the present day. True, there was a less number of cases of cervical fissures and perinaeal lacerations fifty years ago than at the present time ; but that can be readily explained by the more fre- Quent and unskillful use of the forceps. If, then, the mortality is no less where there is so much useless interference, why, I ask, is so much required ? All should require careful, thorough, and complete cleanliness, but do we always have that important factor to aid us in the patient's recovery & When I think of the scenes and surroundings of my early obstetric ex- perience, I am almost led to say that even cleanliness is Scarcely necessary to secure to the parturient female a quick recovery. Ihave spent hour after hour in shanties and log houses, in which I would not now consider it safe to keep my horses; places where, in the winter, the snow 88 NEW YORK STATE MEDICAL ASSOCIATION. could be seen sifting through the crevices, and where, notwithstanding the log fire, my fingers would be so be- numbed with cold, that I could neither make a digital examination, nor ligatet he funis, until my fingers had been first immersed in hot water. No persons were at hand, to care for the patient, save Some temporarily invited neighbors, and no injections were used, yet, the patient recovered. There could have been no nomadic tribes of germs in that day, for in con- nection with this unpropitious state of things, I have Often found upon my next visit, an almost unbearable Odor arising from the bed-clothing. Frequently, upon making further investigations, I would find that the external genitals had had no introduction to soap and water, and that the exsiccated blood had been allowed to remain upon the parts, for fear, if removed, that “she WOuld catch cold.” Added to this evidence of ignorance, was the belief, Quite frequently expressed, and as often carried out, that the placenta should be burned “to prevent a broken breast.” Fortunately, the immense fireplace afforded every facility for its cremation. While writing this paper, my memory goes back to a score or more of abortions, many of them occurring in the unmarried, where, for the purpose of concealment, no physician was at first called in, and where not even ordinary cleanliness was used, for fear of exposure; yet in none of them was an antiseptic injection used, and all, in which the placenta had been expelled, recovered. For many years I was familiar with this state of things— and such a thing as a fatal termination after parturition at term, scarcely entered my mind. True, at long intervals, I would hear of a death from puerperal, or what was then called child-bed fever; yet I had been in practice more than ten years before I saw a case, and that was in consultation. Since that time I have only seen three, these also being seen in consulta- tion. Two of these had been treated by the fashionable ANTISEPTIC TWJECTIONS IN LA BOR. 89 antiseptic injections, but how thoroughly I do not now remember ; yet all died, though they were treated by very clever practitioners. I have performed seventeen craniotomies in my own, and the practice of others, and although no antiseptic injections were used, and frequently even cleanliness was not observed, all of the women recovered. Throughout the early period of my professional work, there was scarcely one who pretended to be a nurse, and if perchance one was found, she was generally some im- pecunious relative or neighboring girl, who was expected to do the work of the house, care for the other children, and possibly milk a cow or two, besides attending to the patient and baby for the stereotyped nine days. At the expiration of this time, the so-called nurse was disposed of, and the mother again took the helm, and went on rapidly to recovery. Now, some may say that “necessity drove this woman from her bed,” but this I deny, for necessity does not guarantee the patient against disease. Picture to yourselves a highly sensitive, intelligent young primipara watching the elaborate arrangements being made for conducting her labor according to the most approved antiseptic methods. Would it be strange for her to exclaim: ‘‘Doctor, has that God whom I have been taught is a synonym of love, after requiring of me obedience to his command to multiply and re- plenish the earth, placed my life in such jeopardy, as to require you at this time to thus fortify yourself as an antagonist of death ? Why am I in greater danger than was the mother who bore me !” Every physician should be governed in his treatment of cases by the results. If, in the management of a large number, the results have been perfectly satisfac- tory without antiseptic injections, how can he expect that a meddlesome change will be of service Strange as it may seem to some, my records show that without the use of any antiseptic injections, I have delivered at term, 90 NEW YORK STATE MEDICAL ASSOCIATION. more than twelve hundred babies, with but one maternal death, and that one occurred after an easy labor, and within fifteen minutes after the extrusion of the pla- centa. I have never been able to explain her death. Now, this extremely favorable showing was not due to the fact that these patients were living in the country, as one of our Fellows remarked when criticising my former paper. Why, may I ask, should we resort to agents, which, if they could do no harm—and who can say they will not—certainly cannot aid us in improving upon the past 7 In an article written by a distinguished gynaecologist of this country, on the subject of antiseptic injections during and after labor, he says: “In private practice, in the homes of comfort, with the attendance of the best practitioners, and the care of good nurses, many a young mother yields her life to the dangers which still accom- pany home confinement. We are told that the records of a prominent insurance company, reveal a mortality of 17 per cent. in private practice, and that among the better class” (italics mine). No greater slander, and I might almost say, untruth, was ever written. I believe statistics will justify me in saying, that the mortality in country practice, and without antiseptics, is not one per cent. Another more radical advocate of antiseptics in mid- wifery, who is quite inclined to question the intelligence, and even the veracity of the country practitioner, says: “I believe that by far the greatest number of general practitioners yet conduct their deliveries in the same way that they learned at college many years ago, and which they have been accustomed to follow since they began to practice.” After having criticised the intelli- gence of those physicians who are not converts to strict antisepsis in midwifery, and who claim a small percent- age of deaths in their practice, he says: “Either their memory fails them, or they have a convenient definition of puerperal fever, in consequence of which puerperae ANTISEPTIO INJECTIONS IN LABOR. 91 die of peritonitis, metritis, pneumonia, pleurisy, heart disease, liver complaint, kidney trouble, meningitis, ty- phoid fever, etc., but never of a disease, the mere men- tion of which, septicaemia, would touch the propriety of adopting the antiseptic treatment.” Poor country doctors, and those of cities who do not choose to follow any man’s dictation in the use of anti- septic agents in obstetric practice, when will you cease to be so ignorant as not to be able to diagnose puerperal fever from pneumonia, or heart disease ? How forcibly does this writer exemplify the familiar proverb–º Alit- tle learning is a dangerous thing !” To those who have been taught that the genital organs of every parturient woman are surrounded by germs, which are ever ready to pounce upon them when they begin that normal physiological work which the Almighty requires for the purpose of peopling the earth, let me say: Do not be startled, but abandon your prejudices, and the future will hear you exclaim—“the otherwise competent physician requires only complete asepsis of the female genital organs after delivery, to make him a successful obstetrician.” THE PALLIATIVE TREATMENT OF SUCH CASES OF CANCER OF THE UTERUS AND ITS ADNEXA, AS ARE NOT AMENA- BLE TO RADIO AL OPER– ATIVE MEASURES. By J. E. JANVRIN, M. D., of New York County. JWovember 15, 1892. During the past few years much has been written upon the radical treatment of cancer of the cervix uteri, and of the cervix and body. The treatment particu- larly appropriate to the first condition, is the high am- putation, as practiced by Dr. Byrne, of Brooklyn, and Dr. Baker, of Boston ; or, in its stead, vaginal hysterec- tomy. The only appropriate treatment in my opinion for the second class of cases, i. e. when the uterus alone, or the cervix and body, is involved, is vaginal hysterec- tomy. In a paper on “The Limitation for Vaginal Hys- terectomy in Malignant Disease of the Uterus,” which I had the pleasure of reading before the Fifth District Dranch of this Association at its meeting in Brooklyn last May, and which was published in the New York Medical Record, July 9, 1892, I endeavored to make clear what my own experience in this operation had taught Iſle. It seems to me that the conclusions there given as to the limitations of vaginal hysterectomy, are perfectly legitimate. The cases appropriate for this operation are those in which the disease is confined to the cervix or uterine body, to both combined, to either of the above, complicated by extension of the disease from the cervix to the vaginal mucous membrane, and to a few cases in which the uterine adnexa is the seat of old inflammatory CANOER OF THE UTER US. 93 exudates. Necessarily all other cases would come within the scope of this paper ; for example, cases in which the disease has diffused itself to the uterine adnexa, or to the peritonaeum, those in which the vaginal wall has become deeply involved, those in which the lymphatics and connective tissue between the vagina and bladder, and between the vagina and rectum are affected, and, consequently, all cases in which the bladder has become involved, and probably nearly all in which the rectum has participated in the disease process. It is possible, but practically extremely rare, that a cancerous neoplasm may develop in the rectum at the same time with, but entirely independent of another malignant growth in the cervix or uterus. In such a con- dition, the removal of the lower segment of the rectum at the same time that the uterus is removed, would be perfectly legitimate, and would not materially increase the immediate gravity of the situation. Unfortunately, however, when both the cervix and rectum are involved in the disease, that portion affecting the latter is gen- erally an extension from the cervix, and hence the infec- tion of the lymphatics precludes any attempt at a radical Operation. In the palliative treatment of all cases in which neither high amputation or vaginal hysterectomy is justifiable, there are many minutiae connected with both the local and internal treatment, which, if observed, tend to delay the advance of the disease, and to relieve the mental and physical sufferings of these poor unfortunates. To accomplish this in the best possible manner, one should have control of a properly appointed hospital or home. It should be located in the suburbs of a city so as to Secure perfect rest and good country air, and yet be Convenient to the attending surgeons. The surround- ings should be cheerful, and its appointments suited to the practice of modern aseptic surgery. The New York Skin and Cancer Hospital fulfills these requirements in its “Country Branch” at Fordham Heights, where accom- 94 NEW YORK STATE MEDICAL ASSOCIATION. modations are furnished for nearly one hundred incura- ble cases. The treatment of these cases during the past eight years has prolonged life, and comforted hundreds who could not possibly have been cared for in any other way. - Now, what can be done for these cases When the tissues have thoroughly broken down and the discharge has become very offensive, and the general health greatly impaired, the first indication is to remove as thoroughly as possible all the necrotic tissue, by careful and extensive curettage. The curettage should remove all the necrotic tissue, and as much of the underlying diseased mass as is possible. To accomplish this, the sharp curette must be made to penetrate deeply into the base of the infiltration. Where the disease is confined to the cervix and surrounding tissue, it frequently hap- pens that the curette penetrates the cul-de-sac into the peritonaeal cavity. Care should be taken, when this is likely to occur, to protect the intestines from injury, by pushing an antiseptically prepared sponge, to which a strong silk thread is attached, up into the cavity, to sup- port the intestines. I have made use of this method on many occasions. Later on, when the final dressings are being applied, a light tampon of iodoform gauze, loosely inserted, keeps the intestines up, and prevents septic ab- sorption by the peritonaeum. As soon as the curettage has been done, all haemor- rhage should be perfectly controlled by such styptics as will not interfere with the further steps of the operation. A saturated Solution of tannin will usually accomplish this ; sometimes the hot water douche is all that is needed. In some cases, the aid of the cautery at a red heat is necessary. If these means fail, it is best to tam- pon the vagina and leave the further steps of the opera- tion for a subsequent date. The haemorrhage or oozing having been perfectly controlled, and the parts wiped dry, pledgets of antiseptic absorbent cotton, squeezed out in a fifty per cent. Solution of chloride of zinc, are applied CANOER OF THE UTER US. 95 to the raw surfaces, care being taken to protect the intes- times and peritonaeum, when the cul-de-Sac has been opened, by proper iodoform packing, smeared on its vaginal surface with vaseline. The same process can be used if the posterior wall of the bladder has been laid bare during the curetting. The vaginal walls below the excavation are protected by pledgets of absorbent cotton thoroughly covered by vaseline. This dressing remains Žn situ for twenty-four hours. It is then removed, and the cavity washed out with a bichloride solution, one to five thousand ; then thoroughly dried, and freely dusted with the iodoform powder. Usually at the end of a week, the sloughs caused by the chloride of zinc begin to come away, and we shortly have a clean surface to deal with. In the majority of cases I have found dry iodoform the best application as soon as the sloughs be- gin to come away. Aristol also acts well. The chief indication is to keep the parts as clean as possible by the use of some dry, stimulating and disinfecting applica- tion. The moist or wet applications, such as disinfecting douches alone, should be used as little as is consistent with cleanliness, for the water remaining in the cavity of the vagina softens the tissues and hastens their disin- tegration. In cases of epithelioma or carcinoma affecting the interior, and the body of the uterus, the same line of treatment is followed. The entire cavity is thoroughly curetted, in many instances to such an extent as to leave but one-third or even one-fourth of its original wall, and as soon as the bleeding is controlled and the cavity wiped out so that it is as dry as possible, the Paquelin cautery at a red heat is introduced, and this, in turn, followed by the fifty per cent. solution of the zinc chloride. There is, of course, nothing new in the use of the chlo- ride of zinc. For many years the late Dr. Marion Sims relied almost entirely upon it in his local treatment of this condition, but it makes all the difference in the world as to the results obtained, whether we first prepare the parts by a thorough curettage, and then stop abso- 96 NEW YORK STATE MEDICAL ASSOCIATION. lutely the haemorrhage and oozing, and thus have a dry Surface upon which to apply the chloride, or simply ap- ply it while the oozing is still going on. In the one case, we get the most thorough effect; in the other, the chlo- ride solution is washed away by the oozing, and often spreads down upon the healthy tissues below, thus doing more harm than good. After the slough caused by the chloride has come away, and we have a clean surface to treat, the applica- tion of iodoform powder, aristol, pledgets of absorbent cotton Squeezed out in spirits of turpentine, or a one to three thousand bichloride solution, will aid materially in keeping the surface in a clean condition for quite a while. Some five years since, I gave the “aveloz” a thorough trial in many of these cases, and found it an excellent application as far as producing a slightly stimulating and caustic effect was concerned. It seemed also to have a somewhat sedative effect, and thus alleviated pain; but the great objection to its use is its expense, and for that reason, more than any other, it has been impossible to use it on an extended scale. After trying almost every kind of local treatment, in- cluding injections of pyoktanin into the cervix, in these unfortunate cases, I have become convinced that more can be accomplished locally by carrying out thoroughly the line of treatment above set forth, than by any other. It remains for us to discuss the point as to whether any internal medication will be of benefit. Of course it is perfectly evident that when the disease has advanced to Such an extent as to absolutely preclude any radical op- eration looking to a cure, the system has become so thor- Oughly infected that internal treatment can be made use Of simply as a palliative measure. For this purpose, ar- senic given after meals in gradually increasing doses up to the point of toleration; the solid extract of red clover, in half or whole teaspoonful doses before meals, and a moderate amount of opiates to control as much as pos- Sible the pain which sooner or later is sure to become OANOER OF THE UTER US. 97 severe, seem to me to fill the requirements in most cases, as well or better than any other remedies. The clover is an excellent stomach tonic, and undoubtedly its good temporary effects are due to this. It is no specific, as is popularly believed, though when given early in the dis- ease, its beneficial action is more apparent than later on ; and I have every reason to believe that when given early and perseveringly, it aids, to a certain extent, in checking for awhile the progress of the disease. Arsenic has the same good effect in these cases that it has in all diseases in which the red blood corpuscles are being destroyed. Frequently when given at the same time with some of the preparations of iron, notably the iodide, it seems for months to supply to the blood a de- gree of nutrition which other remedies fail to give. To relieve pain, and thus help to prolong life and make it endurable, in these incurable cases, is one of the greatest boons which we can bestow. The severe pains are almost always periodical, beginning at a certain hour or hours, every day or night. The greatest good is accomplished by anticipating, as far as possible, their regular occur- rence. The hypodermic use of morphine, or morphine and atropine, half an hour before the pains are due, will always modify, and frequently even prevent these parox- ySms. I have found this method of using morphine far Superior to waiting till the paroxysms begin. I believe the carrying out of these rules, together with the general treatment here mentioned, has been productive of much good in prolonging life, and mitigating suffering ; in this good work a careful attention to details, and the exercise of a great deal of patience on the part of my assistants in the hospital, have rendered valuable assistance. In conclusion, I would add, that in a paper entitled “Waginal Hysterectomy for Malignant Disease of the Uterus,” “I have endeavored to describe clearly the steps of the operation, and have also indicated the kind of Cases in which I have been performing that operation for the past eight years. * New York Jour. of Gynaecology and Obstetrics, Sept. 1892. y A CASE OF PUERPERAL ECLAMPSIA AT THE SEVENTH MONTH, WITH A FEW THOUGHTS FROM PRACTICAL EXPERIENCE AS TO TREATMENT. By Douglas AYREs, M. D., of Montgomery County. November 15, 1892. Puerperal eclampsia, threatening as it always does the life of the mother, cannot fail to seriously disturb the mind of any practitioner of medicine, however extensive may have been his experience. The mother, if she be in labor, suddenly complains of pain in the head, or per- haps of some derangement of vision, epigastric pain, dyspnoea, etc., and soon after has a convulsive seizure, which if once seen, can never be mistaken. The staring eyes, the wonderfully rapid contractions of the facial muscles, the rolling eyeballs, and contractions of the muscles of the neck, drawing the face to the extreme right or left; the livid appearance of the face, the pro- truded tongue, the saliva forced from the angles of the mouth—these take away almost every Semblance of “the human form divine.” This, together with the contrac- tions of the muscles of the extremities, is a condition which has doubtless been witnessed by every physician within the hearing of my voice; and all who have, will acknowledge that it is One of the most serious diseases that we are called upon to treat ; one in which the prog- nosis is always grave, one that requires early and most vigorous treatment. We can congratulate ourselves, per- haps, in this fact, that it is not of frequent occurrence, as various statistics prove that it occurs but once in about five hundred pregnancies. I have selected for this report, a case which occurred in my practice during the past year, on account of its PUERPERAI, ECLAMPSIA. 99 occurrence at the seventh month of utero-gestation, thereby offering serious complications. It is not my purpose at this time to discuss the aetiol- ogy of eclampsia any further than to say, that it may be of uraemic, reflex, or apoplectic origin; that while albumen in the urine may be a very constant attendant, these cases may occur without any, or scarcely any, be- ing present. Great excito-motor irritability may act reflexly and produce them—e.g., irritation of the gravid uterus; but cases that can be traced purely to these causes, I judge from my reading and practical experi- ence, to be very rare. Those of apoplectic origin are undoubtedly the most fatal. I would say in this connec- tion, that I believe that those investigators who think that the greater proportion of these cases have their origin in uraemia, are correct; that is, uraemia in a gen- eral sense, including any or all of the products of the urine, which may be retained, as the result of imperfect action of the kidneys, together with marked increase of arterial tension. The husband of Mrs. F. H. called at my office July 5, 1891, to inform me that she was seven months advanced, in a second pregnancy, and that there was some Oedema of the lower limbs, and some puffiness of the face. I re- quested a sample of her urine for the twenty-four hours, and examined it with reference to the presence of albu- men. I found a large quantity present. The quantity of urine passed was estimated to be about one-third less than the normal average, or about thirty-four ounces. The usual treatment was advised—mental quietude, milk diet, iron tonics, and mild laxatives. About 4 P. M. On July 9th, four days after his first call, I was hastily Summoned to attend her. Her mother gave me the fol- lowing history: She had felt as well as usual that day, until the afternoon, when she complained of some pain in the head, and went into another room, to lie down up- On a couch. Shortly after, the mother heard a sound, as Of Something falling, and going hastily into the room, J } * tº e = * 100 NEW YORK STATE MEDICAL ASSOCIATION. she found her daughter lying upon the floor in an uncon- scious condition. There were slight convulsive move- ments. The patient recovered consciousness in a short time, and was then placed on the couch, where she lay quietly, asking some questions with regard to what had happened, but in a somewhat dazed manner. When I arrived, she seemed perfectly conscious of her surround- ings, and answered intelligently the few questions put to her. I remembered that I had attended her in confine- ment eleven years before, and that immediately after the birth of the child, she had had an eclamptic convulsion, for the relief of which I bled her very freely, removing nearly thirty ounces, which seemed only sufficient to reduce the force and volume of the pulse. After this, she rallied ; and very luckily there was no recurrence. When I first saw her, this time, the face was puffy, and the lower ex- tremities quite oedematous ; she was thirty-six years of age, a person of full habit, weighing, perhaps, one hun- dred and forty or fifty pounds. There had been in the past few days, no noticeable diminution in the quantity of urine. Cold applications were Ordered to the head, a stimulating enema was given, and, by mouth, a full dose of calomel and jalap. She soon had a severe convulsion. Venesection was immediately performed, and it was necessary to remove nearly twenty-five ounces before she returned to con- Sciousness. There were now marked uterine contrac- tions, and a vaginal examination showed the os somewhat softened and dilatable. After dilating slowly and care- fully with the fingers, three-quarters of a drachm of the fluid extract of ergot, and one-third of a grain of mor- phia were administered, and shortly afterward the forceps were applied. By gentle traction during each pain, I succeeded in a short time in delivering a dead child. The uterus was carefully kneaded, and within a half or three-quarters of an hour, the placenta was ex- pelled. There was but a moderate amount of haemor- rhage, as the uterus seemed to contract fairly well. The PUERPERAI, ECLAMPSIA. 101 patient was now breathing easily, and quite unconscious; pulse regular, and of fair strength. As she could swal- low, a few ounces of milk were slowly given. She re- mained in this condition for about three hours, when another convulsion occurred, which was, perhaps, not so severe as the previous one. The urine was then drawn by catheter, and was found to contain about the same quan- tity of albumen as before. I was unable to obtain any chlo- ral until about two hours later, at which time there were evidences that another convulsion was about to occur. I immediately injected per rectum fifty grains, properly guarded with mucilage. She was quiet for nearly six hours, when there were muscular movements, evidencing a recurrence, so the same amount was again injected. It was necessary to make two more of these injections, at about the same intervals, before all evidences of recur- rence ceased. My patient remained in a partially un- conscious condition for nearly fifty hours, but she took Some milk at regular intervals. From this time on, she began to recover, her convalescence extending over a pe- riod of sixteen or seventeen days, during which time she was troubled with amblyopia to such an extent as not to be able to recognize any object brought within the usual focal distance. There was a good deal of muscular ten- derness, and quite marked prostration. The after-treat- ment was tonic and alterative, with the usual aseptic and antiseptic precautions. There are a few questions of moment, which the treat- ment of this case suggests: 1st. How important a factor is venesection for the relief of the condition ? 2d. What cases would be most likely to be benefited by it . - 3d. What is the value of chloral as a therapeutic measure compared with chloroform by inhalation, and morphia by subcutaneous administration ? I believe that the prompt action of chloral makes it an agent of the utmost importance; that it relieves the brain 102 NEW YORK STATE MEDICAL ASSOCIATION. by lessening the force of the circulation and consequent arterial tension ; and that it thereby wards off a threat- ened brain lesion, at the same time that it protects the endangered heart. But it is of the utmost importance that it be administered before an irreparable injury has taken place. It favors the action of the kidneys, and gives us time to make use of other remedial agents cal- culated to relieve the general oppression ; and, as a prominent writer has said, it favors absorption, and renders the patient more susceptible to this influence. In the second place, I believe that women of full habit with suffused face, and full, slow pulse, showing much arterial tension, will always be greatly benefited by venesection, and my personal experience has been, that where this important measure has been neglected, death has been much more frequent. I call to mind in this connection eight cases which I treated by bleeding; in three, with the addition of chloral to the treatment. There was only one death, a primipara, sixth months pregnant, whom I did not see until a serious brain lesion had taken place. Barqueseau says: “Venesection diminishes the general mass of the blood, relieves the nerve centres, which have a tendency to become congested, and by making the spinal bulb anaemic, we deaden reflex irritability, which keeps up the hyperaemia, and by which the convulsive attack may be revived.” It is now something over twenty years since chloral- hydrate became a prominent remedy in the treatment of eclampsia. My first experience in the use of it at that time was by subcutaneous injection. I was called in consultation in a very severe case where the patient had a number of convulsive seizures after free venesection. I had seen but a few days before, an article in some of our journals, about the use of the remedy subcutaneously. I suggested it, and we made trial of it, injecting it freely in the lower extremities. It relieved our patient, but it was some time before the ulcerations resulting from these injections were healed. I have since adminis- PUERPERAL FOLAMPSIA. 103 tered it per rectum, as it is much more quickly and easily given in this way, and, as many times, it cannot be given by the mouth. I certainly much prefer it to chloroform ; for although chloroform arrests the convulsive seizures, it is usually only for a short time, and the patient can- not be kept under its influence, for a length of time, without danger. It produces congestion of the nerve centres, and so may increase cerebro-Spinal congestion, and also the asphyxia, to which complication there is a predisposition. Depaul admits that it does modify, to a certain extent, the eclamptic attacks; but Says they as well as the complications exist none the less. There is no doubt but that we have in morphia and chloroform valuable remedies, the effects of which have been closely and practically investigated by the profession, and that they have held their place in professional confidence; still, it seems to me, that some of the arguments pre- sented, especially that against its long-continued use, are well founded. As to morphia subcutaneously, I can fully indorse its use, in doses not to exceed one-quarter of a grain, to be repeated if necessary within, Say, one hour; but I should fear the heroic doses recommended by some writers, of from one-half to one grain, boldly repeating it upon evidences of a recurrence, notwith- standing the tolerance of the drug in eclampsia. I believe that we have in hydrate of chloral an agent of wonderful therapeutic value for the relief of reflex irri- tation, and that we have in judicious, prompt, and bold venesection, and in chloral, two agents, which will never be supplanted by any more perfect or potent measures. After twenty-seven years of active practice, I can recall many cases treated in this manner, and the great majority have recovered, some by venesection alone, others by the two combined; but the former has been my sheet-anchor, and I firmly believe, that when early and judiciously done, it has saved, and will con- tinue to save many mothers from an untimely death. T04 NEW YORK STATE MEDICAL ASSOOIATION. DISCUSSION. DR. EDEN. W. DELPHEY, of New York county, said that among the more common causes of puerperal eclampsia were, high arterial tension, a watery condition of the blood, and quickened reflex activity, and, accord- ing to recent European experimenters, the “bacillus of puerperal eclamp- sia.” These observers have been able, by injections of cultures of this bacillus into animals, to produce true eclamptic seizures. The arterial tension and the watery condition of the blood are best treated by venesec- tion, and for the quickened reflex activity, the treatment should be first by inhalation of chloroform, and afterwards by the administration of chloral and the bromides. About sixteen months ago, he saw a very severe case of puerperal eclampsia, in which the examination of the urine showed this secretion to be very scanty, and to contain only one and a half to two grains of urea to the fluid ounce. TUMIOR'S OF THE ORBIT. A DETAILED ACCOUNT OF NINETEEN CASES II, LUSTRATING: THE PAPER ON THE SAME SUBJECT, PRESENTED TO THE NEW YORK STATE MEDICAL ASSOCIATION AT ITS MEETING IN 1891. By CHARLEs STEDMAN BULL, M. D., of New York County. (Read by title November 15, 1892.) CASE I. A boy, four and a half years of age, was brought to me by his parents, in the latter part of January, 1876, with the following history : He was a large child for his age, of the average mental devel- opment, and had always been in robust health. There was no unfavora- ble family history elicited after careful questioning, and no evidence of inherited syphilis in the child. For several months the parents had no- ticed a slight swelling at the outer angle of the left orbit, accompanied by slight redness of the eyeball, and some swelling at the outer angle of the upper lid. These symptoms gradually increased, but there was no com- plaint of pain, and no evidence of any disturbance of vision. When I saw the child, there was a very perceptible orbital growth at the outer angle, which seemed to involve the upper and outer parts of the orbit. The left eye was pushed downwards and inwards, but not forwards, and its motil- ity upwards and outwards was decidedly limited. The upper lid was slightly swollen, and drooped a little, but could be freely opened and shut. The growth was entirely non-sensitive. The media were perfectly clear, the iris reacted promptly, and the ophthalmoscopic examination was neg- ative. Vision was apparently normal. There was a slight mucous dis- Charge from the conjunctiva. A careful rhinoscopic examination revealed nothing abnormal. No history of any injury could be obtained. The boy was watched carefully, and by the middle of February the symptoms had all increased. The eye was displaced downwards more decidedly, and motility upwards was entirely lost. For two days the child had com- plained of some pain. The pre-auricular gland on the left side had become swollen and somewhat painful. Ophthalmoscopic examination was nega- tive. By the first of March all the symptoms were much increased in Severity. A slight ulceration of the cornea appeared just above the centre. The motility of the eye was limited in all directions. The left pre-auricu- lar gland was very much enlarged, but there was no other glandular infil- tration. The orbital margin was swollen, and the swelling extended upon the forehead and backwards into the temporal fossa. There was little or no protrusion of the eye forwards, and the lids could still be opened. 106 NEW YORK STATE MEDICAL ASSOCIATION. A diagnosis was made of pure orbital tumor, probably starting in the periosteum, and owing to the somewhat rapid increase of the symptoms and the high fever of the last two days, it was decided to operate and at- tempt to save the eye. - On March 3d the left external canthus was split, the incision being car- ried outwards upon the temple for somewhat more than an inch. The left temporal artery was divided, and at once ligated. The upper lid was then carefully dissected upwards and turned over upon the fore- head. After the bleeding had been checked, the orbital periosteum was found very much thickened on the outer and upper walls of the Orbit. The infiltration also involved the orbital tissue as far back as the finger could extend, but did not seem to involve the capsule of the eyeball. The latter was pushed carefully towards the nasal side, and held there. An in- cision was then made through the periosteum along the Superior orbital margin, and the periosteum was then carefully stripped up from the bone on the upper and outer walls of the orbit, as far back as the knife and for- ceps could reach. This was removed in strips, and with it also the orbital tissue and the lachrymal gland. The periosteum was also removed from the frontal bone and temporal fossa as far as it seemed to be infiltrated, and the pre-auricular gland was carefully dissected out and removed. The orbital cavity was then washed out with a mild solution of zinc chloride, and the upper lid was brought down in place, and the lines of incision carefully coapted and sutured. Atropine was instilled, and the eye closed with the ordinary dressings then in use. For the first three days there was considerable reaction, the lids being much swollen, and the wound dis- charging considerable pus, so that one or two stitches had to be removed. The cornea became generally hazy, but did not slough, and eventually cleared up remarkably. On March 15th a purulent discharge came on from the left ear without any preceding pain, but was followed by severe pain, extending down the left side of the neck, and accompanied by high fever and a pulse of 140. An examination showed a perforation of the membrana tympani just be- hind the handle of the malleus. The discharge from the auditory canal ceased in four days, but the perforation did not close for nearly three weeks. From this time there were no adverse symptoms, and the patient. was discharged at the end of the sixth week. A microscopical examina- tion of the growth proved it to be a spindle-cell sarcoma, which had origi- nated in the periosteum. The little patient was seen regularly once a month, but there was no return of the growth until the spring of 1880. Its progress was then very rapid, for in less than two months it filled up the entire orbit, causing marked exophthalmos, and destruction of the eye- ball by sloughing of the cornea. The entire contents of the orbit, includ- ing the eyeball and the entire periosteal lining, were then removed, as far back as the apex of the orbit, by a second operation. The orbit was care- fully washed out with a solution of mercuric bichloride (1–1000), and the lids were closed and dressed in the usual manner. The patient did very well, there being little or no reaction, and he was discharged at the end of TU MORS OF THE ORBIT. 107 a week. He was seen at rather irregular intervals, although his parents had been warned that the growth would probably return. In May, 1885, he presented himself with a swelling of the lower lid and cheek on the left side, which had appeared two weeks before. This proved to be a dense in- filtration of the tissues of the lid and cheek, springing undoubtedly from the diseased periosteum at the edge of the orbit. There was no return of the growth in the orbit, and the appearance of the external infiltration did not suggest its having spread from any complication in the maxillary sinus. The parents declined to permit any further operative interference, but allowed me to keep the boy under observation. The orbit gradually filled up with the growth, while the external infiltration steadily advanced into the temporal fossa, over towards the nose, and upwards upon the fore- head; and the patient finally died from exhaustion, without any head symp- toms, a little more than ten years after the first appearance of the tumor. CASE II. Mrs. A. H., twenty-nine years of age, came to me on June 12, 1876, with the following history : Twelve years before, a small growth appeared at the external angle of the left orbit, just beneath the superior orbital margin. It was the size of a large pea, and for a number of years occasioned no discomfort, and showed no tendency to increase in size. After about six years of quiescence it began slowly to grow, and continued to do so until it reached the size of a walnut, and caused a protrusion of the upper lid and external canthus, and a slight displacement of the eye inwards. It then ceased growing, and remained quiet until about four months before I saw her, when it suddenly began to increase in size, and became very painful. On examination, I found the following condition of the parts: The upper lid was pushed forwards, and drooped considerably Over the eye, but could be elevated, and the skin was of a marked dusky red color. The eyeball was pushed downwards and inwards, and protruded nearly half an inch beyond the plane of the fellow eye, and its motility was limited in all directions. The conjunctiva was injected and the palpebral Veins were engorged and prominent. The media were clear, and the retinal veins were extremely engorged and tortuous. The patient com- plained of a constant pain over the anterior surface of the superior maxilla and at the infra-orbital foramen, and during the last four months, the vis- ion of the left eye had materially failed. She could count fingers at twenty feet, but was not able to read. The other eye was normal. The tumor could be seen and felt through the lid, and by careful palpation the growth could be felt along the floor and outer wall of the orbit. Rhinoscopic ex- amination revealed a displacement of the septum nasi towards the right Side, and a nearly complete obliteration of the left nasal meatus by what appeared to be a moderately hard mass coming from the middle meatus. Nothing could be felt with the finger posteriorly. The patient stated that for some months she had not been able to breathe through the nose. With this history, and the digital examination, it seemed probable that the tumor had begun in the maxillary antrum or nasal meatus, and had involved the orbit secondarily. Assuming this to be a correct diagnosis, the patient Was told that the only means of relief was an operation, but that owing to 108 NEW YORK STATE MEDICAL ASSOCIATION. the deep-seated nature of the growth, and its probable origin, its removal would probably not be complete, and it would be likely to return. She was also told that in all probability the left eye could not be saved, but that an attempt would be made to preserve it. The vision by this time had sunk to counting fingers at two feet, and the optic disc was beginning to assume a dirty-white color. She consented to an operation, which was done on the following day. The external canthus was split, and the upper lid turned up over the forehead, and held there. A further examination with the finger and large probe, showed that the entire orbit was filled with the growth, and that any attempt to save the eye would prove a failure. Enucleation was immediately done, and then the entire contents of the orbit were carefully removed. The tumor could then be seen projecting through a large opening in the orbital plate of the ethmoid, and also through the sphenoidal fissure. It evidently filled the ethmoidal cells, extending to them from the superior and middle nasal meatus, and was of much greater extent than had been at first recognised. The orbital plate of the ethmoid was then removed, and all the growth that could be reached was dissected out. The floor of the orbit had not been perforated, and the possibility of the autrum not being involved was recognised. The lachrymal bone was next removed, and a free opening made into the nasal meatus. This was found filled with the growth, which was removed by forceps and fingers as far down as possible. It was necessary to break down and remove the entire inner wall of the orbit, and even then the growth could not be reached without great difficulty. The nasal meatus were cleaned entirely of the growth by working from below through the nostril, as well as from above, and then the orbit, ethmoid cavity, and nasal meatus were thoroughly washed out with a solution of carbolic acid. A careful examination of the opening from the maxillary autrum into the nasal meatus was made, but no protrusion of the growth, or enlargement of the opening discovered. The orbit was then tamponed, the upper lid replaced, and the canthus sutured, and the ordinary bandage applied. The patient did very well, having but little local reaction, and but slight rise in tem- perature. She was discharged on the eighth day, with directions to report once a week until further orders. There was no return of the growth for eight months, when a small nodule was noticed in the left temporal fossa. The left nostril still remained free, and the orbit was healthy and normal in appearance. The patient was urged to allow the removal of this exter- nal nodule, but declined to have it done. It grew slowly to the size of a walnut, and then remained quiescent for several months. It then Sud- denly began to increase, and at the same time a nodule was felt at the apex of the orbit, and another on the inner side, in the cavity of the ethmoid bone. All these nodules grew rapidly, and the one in the temporal fossa soon extended from the lower margin of the zygoma upwards and forwards upon the forehead, and backwards to the auricle. The lower portion was moderately hard, but the portion which extended upon the forehead was soft, fluctuating, and very sensitive to the touch. All further operative interference was declined, as it would undoubtedly have hastened the TU MORS OF THE ORBIT. 109 patient's death, which occurred after great suffering, four months later, and about thirteen years after the first appearance of the growth. Before the patient's death, the orbit and nasal meatus had become entirely filled with the growth, which had also extended back into the pharynx. The tumor removed from the orbit and neighboring cavities was Sarcoma- tous in nature, of the small-cell variety, but in places was distinctly myxo-sarcomatous. After the patient's death I was permitted to examine the orbit, and found that the neighboring cavities, including the maxillary sinus, were entirely filled by the growth, though the floor and roof of the orbit were still intact. CASE III. A young gentleman, twenty-two years of age, consulted me in December, 1879. The left eye had been defective in vision since child- hood, and occasionally squinted. For the past two weeks there had been a constant dull pain in the orbit, with ptosis and Some protrusion of the left eye. Examination showed limitation of motility in all directions, chemosis of the ocular conjunctiva on the temporal side, Some ptosis and slight exophthalmos; media clear, fundus normal, and W- #3. On the floor of the orbit, reaching from the infra-orbital notch to the external canthus, was a hard, resisting growth, which pressed the lower lid for- ward, and which could be traced for some distance backwards into the or- bit. It was very sensitive to pressure. The patient declined all operative treatment. By February 16th the exophthalmos was very marked, and the patient complained of severe occipital headache, and at times staggered when he walked. The lower lid was everted, and the orbital growth was very prominent at the external angle. There was dense infiltration of the palpebral and ocular conjunctiva, the eye was immovable, the cornea was hazy, and vision was reduced to perception of light. The patient also complained of constant pain in the region of distribution of the infra- orbital nerve. He consented to an operation, and two days later the eye was enucleated, and the tumor removed with comparative ease. The latter was attached very firmly to the sheath of the optic nerve, and only loosely to the orbital tissue, but the latter was densely infiltrated especially along the floor of the orbit, and on this account the entire contents of the orbit were removed down to the periosteum, which latter seemed perfectly healthy. The infiltration of the orbital tissue, and the pain over the infra- Orbital nerve, led me to make another careful rhinoscopic examination, but nothing abnormal was found. The tumor, on being examined, proved to be a spindle-cell sarcoma, and the orbital tissue was infiltrated with small round cells. By the middle of April, or two months after the first operation, there were well marked signs of a recurrence of the tumor in the periosteum on the floor of the orbit. A second operation was immediately done, the peri- Osteum, which was very much thickened, being stripped up on all sides from the orbital margin to the apex. It was very vascular and the haemor- rhage was profuse. The orbit was then washed out with a strong solution of carbolic acid, and a careful examination with the finger was made of the floor, inner wall, sphenoidal fissure and optic foramen, but no trace of 110 NEW YORK STATE MEDICAL ASSOCIATION. abnormal growth could be discovered. The haemorrhage still continued, and it became necessary to plug the orbital cavity. Violent reaction fol- lowed in the skin of the lids, cheek and temple, and the tampon was re- moved on the next morning. The skin of the left side of the face became decidedly erysipelatous. The reaction slowly subsided, but left both lids retracted and adherent to the external angle of the orbit, and the lower lid adherent to the inferior orbital margin for its outer third. The cavity of the orbit was much contracted, but the floor was found intact. Two months later, on June 25, 1880, a firm nodule, as large as a filbert, appeared over the left molar prominence. It was firmly adherent to the periosteum, but the skin was freely movable over it. In a month this nodule had increased threefold in size, and was elastic and sensitive to the touch. Another nodule, much smaller, was discovered along the lower margin of the orbit. On July 30th these two external nodules were thor- oughly removed, the bone was carefully scraped, and then cauterised with the actual cautery. By the first week in September, an external tumor over the molar bone had returned, and had reached the size of a small pear, but it was very irregular and nodulated. The skin was drawn tightly over it and was but slightly movable. This external growth was found to be continuous with an orbital growth, which involved the floor, inner and outer walls of the orbit, while the external growth extended down upon the superior max- illa, and over into the temporal fossa. The patient urged a fourth opera- tion, which was done in the following way : An incision was made along the lower lid-margin as in the Arlt-Jaesche operation for entropium, and was extended an inch and a half from the external canthus towards the ear. A second incision was made from the inner end of the first incision down along the nasal furrow to the ala of the nose. This skin flap was carefully dissected up and reflected from the growth. The haemorrhage was profuse, and it was necessary to ligate several vessels. The extra- orbital portion of the growth was then thoroughly removed, and there was then revealed a ragged opening through the anterior wall of the superior maxilla into the antrum, through which the growth protruded. The tumor was then removed from the orbit, and here a large ragged hole was discov- ered through the floor of the orbit leading into the antrum, The tumor filled the antrum, nasal meatus, ethmoid cavity and sphenoidal fissure, and as much of it as could be reached was removed, the antrum and nasal meatus being thoroughly emptied. The parts and cavities were then thor- oughly washed out with a solution of mercuric bichloride (1–1000), and the wound closed. No great reaction followed, though the temperature went up to 103°, and there was not much suppuration. The external wound healed, but in less than six weeks the growth again appeared in the orbit and externally over the molar bone. The case had long been regarded as hopeless, but the patient lingered in great suffering till the latter part of January, 1881, and died from exhaustion, about fourteen weeks after the apparent commencement of the disease. TUMOR'S OF THE ORBIT. 111 CASE IV. In the latter part of September, 1880, a woman, forty-two years of age, from whom I had previously removed a small growth, appar- ently epitheliomatous in character, from the inner angle of the left lower lid, three years before, presented herself with the following history: There had been no trouble with the eye or lids for nearly two years. The eye then began to be limited in motion outwards, and to slightly protrude. These symptoms slowly increased, the upper lid became swollen, and a constant dull ache in the orbit began. Finally the sight of the left eye began to fail, and this frightened her and brought her to me. An examination showed the right eye to be normal in every respect. In the left eye the vision was #} unimproved ; the media were clear; there was a grayish dis- coloration of the temporal half of the disc, and a narrowing in the calibre of the arteries. The perimeter showed a contraction of the nasal half of the field. The left upper lid was decidedly Oedematous and somewhat reddened. The eyeball was pushed inward, and protruded very percepti- bly in advance of the plane of the other eye. There was a decided infil- tration of the tissues on the temple and on the cheek just below the inferior orbital margin. The patient was told that she probably had a tumor of the orbit, and that it must be removed, but that an attempt would be made to save the eye, and she consented to the operation. As the exophthalmos was directly forward, and the limitation of motility was outwards, the conjunctiva was divided at the outer canthus, and the wound then en- larged upwards and downwards. Almost immediately a growth was felt, extending along the outer wall of the orbit and filling the entire apex. The external rectus muscle was then divided at its insertion, and the eye- ball turned far inwards. The dissection of the tumor was then continued, but it was found so intimately connected with the sheaths of the muscles and of the optic nerve, as well as with the periosteum, that I cut through the nerve and the muscles near the apex of the orbit, as a necessary pre- liminary to the removal of the tumor from its orbital attachments. The growth extended on the inner side of the eye as well as on the outer side, and after considerable trouble was removed, leaving the eye in place. About three-quarters of an inch of the optic nerve were removed with the tumor. The floor of the orbit appeared healthy and there was no demonstrable connection between the growth in the orbit and the infiltra- tion in the cheek and temple. There was no reaction, and the patient was discharged at the end of ten days. The eyeball became slowly atrophic and the cornea cloudy. This case was watched very carefully, being seen every week or two, as the history of the case pointed to a recurrence of the tumor. The infiltration of the cheek and temple slowly subsided, and at the end of three months there was nothing abnormal in the patient's appearance except the atrophied eyeball. Nearly ten months after the opera- ation, however, there appeared a well-marked nodule on the external surface of the Superior maxilla on the left side, just below the orbital margin, and external to the infra-orbital foramen, and the diffuse infiltration reappeared on the temple. The eyeball, which had previously receded into the orbit, began again to protrude. Another careful examination was made of the 112 NEW YORK STATE MEDICAL ASSOCIATION. naso-pharynx, but nothing abnormal was discovered. As the microscopical examination of the first tumor had shown it to be a small-cell sarcoma, I advised an immediate operation, including the removal of the atrophied eye, but the patient refused her consent until November, 1881, nearly four months after the reappearance of the growth. She was then suffering severe pain at times in the orbit and temple. The eye again protruded beyond the orbital margin, and the growth on the cheek had become as large as a horse-chestnut, and was very sensitive. The skin was movable over this growth, which was firmly adherent to the bone. The eyeball and en- tire contents of the orbit were first removed. After the haemorrhage had been checked, a careful examination showed a defect in the orbital plate of the ethmoid rather far back, and another in the floor of the orbit. A probe passed through these openings into the ethmoid cells and maxillary an- trum discovered a gelatinous mass of considerable consistency in both. This was sufficient evidence that both these cavities were filled with the morbid growth. The large nodule was then removed from the su- perior maxilla, and the external surface of the bone carefully examined, but no opening into the antrum was found. No further attempt was made to remove the growth from the cavity of the ethmoid or the antrum, both on account of the severity of the operation and the hopeless- ness of any successful removal of the diseased bones. The patient made a good recovery, and there was no return of the external tumor on the sur- face of the superior maxilla. The disease, however, soon extended from the neighboring cavities into the orbit, and also invaded the nasal meatus, and made rapid progress. The patient suffered considerable pain, and the nasal cavity soon became so completely blocked that she breathed almost entirely through the mouth. In three months the growth filled the orbit and protruded between the lids, and could be seen at the entrance of the left nostril. About four months after the last operation, she began to complain of intense frontal headache, which at times rendered her delirious, and in one of these severe paroxysms she had a violent convulsion. This was general in character, and ended in coma, from which she never rallied. An autopsy could not be obtained. CASE W. On January 12, 1881, a gentleman, thirty-eight years of age, presented himself at my office with the following history: The first symp- tom which he had noticed had been a protrusion of the right eye, which began five years before, and five months later the left eye also began to protrude. During these five years there had been a steady increase in the exophthalmos and in the limitation in motility of both eyes in all directions. There had been some pain of late, which was located at the root of the nose and just above both eyes. For a long time, but just how long he did not know, there had been difficulty in breathing through the left nostril, and for more than a year, respiration was entirely abolished through both nostrils, and he had become an absolute mouth-breather. He had several polypi removed from the right nostril at different times, with a temporary improvement in breathing. An examination showed a marked protrusion forwards and outwards of both eyes, so that the lids could with difficulty TU MORS OF THE ORBIT. 113 be closed over them, and the axes were widely divergent. At one period of the disease there had been crossed diplopia, which subsequently disap- peared. The eyes were almost immovable, and the ocular conjunctiva was deeply injected. The irides responded to light, the media were clear, and the ophthalmoscopic examination showed nothing but engorged and pul- sating veins. R. E. W = +}o : L. E. W = perception of light. The sight had begun to fail one year ago in both eyes, and had slowly grown Worse. There was pain on pressure backwards of the eyeballs. The posterior nares on both sides were blocked by a growth extending across the anterior pharyngeal space. The left nostril was occluded. The right nostril was blocked by a polypus, which apparently grew from the left wall of the meatus, entirely filled it, and pushed the inferior turbinated bone and septum nasi over to the left side. It was soft, and bled easily. The growth behind, which filled the posterior nares, and extended into the pharynx, was hard and resistant, and apparently was attached to the body of the sphenoid. Nothing was discernible on the floor or inner wall of the right orbit, but in the left orbit the floor was pushed upwards, and the orbital plate of the ethmoid pushed outwards, and I thought I could detect a tumor in the orbit. The external surface of both cheeks and temples was Smooth and normal in appearance. The desperate character of the case was at once recognised, and the patient was told that a complete removal of the growth was hopeless, but that the growth could be removed from the nostrils, and his respiration made more comfortable. To this operation he consented, and the nostrils were cleared both anteriorly and posteriorly. A large, gelatinous polypoid mass, attached to the outer wall high up, was removed from the right nos- tril. By means of a guarded bistoury, blunt scissors and polypus forceps, the entire mass was removed from the posterior nares, including with it a large portion of the inferior turbinated bones. The haemorrhage at first Was profuse, but was soon checked, and a careful examination of the parts made. The whole middle and superior nasal meatus were filled with the growth, which could also be felt protruding from the opening into the left maxillary antrum. After the first week, I did not see this patient again until five months had elapsed, when he came once more for the relief of his respiration. His condition was then deplorable. The left eye was sightless, the cornea cloudy and ulcerated, and the lids could not be closed. The growth had appeared as a large protuberance at the left inner canthus, projecting through the lids, and had also appeared at the inferior margin of the orbit and filled up the temporal fossa. He had perception of light still in the right eye, in which the optic disc was found in a condition of gray atrophy. Both nostrils had again filled up with a solid, somewhat resistant mass. I repeated the same operation, removing as much of the growth as could be reached, and again rendering the nostrils free. The maSS Was not polypoid, but on both occasions proved on microscopical examination to be myxo-sarcomatous in character. In two months the nasal meatus had filled up again, while the growth in the right orbit had increased very rapidly. He suffered greatly from pain 8 114 JNETW YORK STATE MEDICAL ASSOOIATION. deep in the orbits, and from frontal headache, but lived for nearly four months longer without any additional head symptoms, and finally died from exhaustion. In this case, although all the deep bones of the face and base of the skull had become involved, the tendency of the growth had been outwards. In spite of persistent urging, an autopsy was positively refused. Before death the tumor had perforated the conjunctiva at the inner angle of the left eye, and extended over the side of the nose and down upon the cheek. CASE. VI. Early in August, 1881, a woman, forty-five years of age, consulted me and gave the following history : About two months before, a Small, dark nodule had appeared at the supero-temporal margin of the left cornea, Seated mainly in the conjunctiva. It was slightly movable, and slowly increased to the size of a small lima bean. When I saw her, the growth had encroached somewhat upon the cornea, and was painless to the touch. On August 18th, I removed the tumor, which was found to be adherent to the Sclera, and extended somwhat along the infero-temporal margin of the cornea. It was friable, and bled easily. It was thoroughly removed, and the surface of the sclera was then scraped and cauterised, and the edges of the conjunctiva were brought together loosely over the wound. I did not see the patient again until November 4th, when the growth had returned. The tumor occupied the upper, outer, and lower Quadrants of the ocular conjunctiva and sclera, and covered the temporal third of the cornea. It was irregularly lobulated and somewhat flattened, dark in color, quite vascular and non-Sensitive. It extended above the eyeball into the orbit as far as the equatorial region, the eyeball was dis- placed slightly towards the nose, and its motility upwards and inwards was limited. The field of vision was narrowed on the temporal side, but central vision was still #} + and the fundus was normal. The patient was told that the eye must be enucleated at once, and on November 21st, the entire contents of the orbit, including tumor, eyeball and ocular con- junctiva were removed. The optic nerve was divided far back and looked perfectly healthy, and the periosteum of the orbit also appeared normal. The case did well, and there was nothing abnormal noticed until the following June, 1882, when a small dark nodule was found on the outer wall of the Orbit about half-way back. The patient declined another operation, and I did not see her till the last of October, when the growth filled the Orbit and protruded between the lids. It seemed as yet to be confined to the orbit, for the naso-pharynx was clear and there was no evidence of any trouble in the maxillary antrum. The patient now consented to an Operation, and on November 2, 1882, the entire contents of the orbit were again removed with ease, though the haemorrhage was profuse. The periosteum was then cut through all round the orbital margin, and was then stripped up on all sides as far as the apex of the orbit, and removed. After the haemorrhage had ceased, the bone was thoroughly Scraped, and then the orbit was washed out with a sublimate solution (1–1000). These was little or no suppuration, and the raw surface soon healed. I saw this patient at intervals until the autumn of 1886, a TU MORS OF THE ORBIT. 115 period of four years, and there was no return of the tumor in that interval. She then disappeared from observation, and I have heard nothing of her since. All the specimens removed at different times and examined, proved to be true melano-sarcoma. The eyeball proved a very interesting specimen. The tumor was almost entirely superficial and extrinsic. None of the tissues of the eye were invaded by the growth, except the Sclera, and even here only the superficial layers were infiltrated by the Sarcoma cells. The region of the lymphatic channels round the opening of the vasa vorticosa was entirely free from any infiltration, as were also the sheath of the optic nerve and the nerve itself. CASE VII. A gentleman, H. A., twenty-two years of age, was first seen June 12, 1882, and gave the following history : He had always been perfectly well, and had never noticed anything abnormal about his eyes until five months ago, when the right eye began to protrude. Since then, the exophthalmos had slowly but steadily increased, but there had never been any pain. The vision of the right eye remained good until ten days ago, when it suddenly became impaired. Examination showed that vision was reduced to perception of light ; the protrusion of the eye was forwards and slightly outwards, and motility outwards and inwards was decidedly impaired. The iris reacted, the media were clear, and the fundus showed a well-marked condition of papillitis with haemorrhages. At the inner side of the orbit, a tumor could be felt, apparently springing from the inner wall of the orbit, and sensitive on pressure. The left eye was normal in every respect. The patient was told the probable nature of the trouble, and consented to an operation, which was done on June 14th. The external canthus was incised outwards for an inch, and the upper lid turned up on the eyebrow. The ocular conjunctiva was divided in the horizontal merid- ian, from the internal canthus to the corneal margin. The tendon of the internal rectus muscle was next divided, and the eye turned strongly to the temple. The tumor could then be plainly seen on the inner wall of the Orbit, its anterior aspect being flattened. By means of a blunt hook, and blunt pointed scissors, it was readily dissected from its periosteal adhesions and removed entire with but trifling haemorrhage. It proved to be a long, flattened growth, the size of a large lima bean, and was apparently entirely enclosed in a capsule. A careful examination of the orbit discovered no trace of any further growth, and the muscles and optic nerve seemed to be intact, though the latter was somewhat flattened. The cavity was then carefully washed out with a sublimate solution (1–2000). The tendon of the internal rectus was stitched in place to the sclera, the conjunctiva brought together, and closed over the opening with sutures, and the slight Wound in the canthus closed in the same way. The eye was then bandaged in the usual manner. Not a drop of suppuration occurred, and the patient Was discharged at the end of a week. The tumor was hardened and Sections were carefully made in all directions. It proved to be entirely en- closed in a fibrous capsule, and was divided into several parts by fibrous trabeculae, which seemed to be prolongations inwards of the fibrous 116 NEW YORK STATE MEDICAL ASSOCIATION. capsule. The spaces between the trabeculae were filled with large and Small round cells, with nucleus and granular contents. Regarded as a whole, the growth would be classed as a sarcoma, or possibly a fibro-Sar- Coma, as there were a few fusiform cells between the fibres of the trabeculae. The superior oblique muscle was not injured. The patient’s vision slowly improved, so that at the end of a month he could count fingers at three feet from the eye ; but beyond this it did not improve, and event- ually the optic disc took on the appearance of gray atrophy. The patient was last seen in the autumn of 1884, a period of more than two years after the operation, during which there had been no return of the growth, and from the encapsulated condition of the tumor, it is probably safe to conclude that it has not reappeared. . CASE VIII. Fanny S., seventeen years of age, was first seen on Sep- tember 24, 1884. Two years before, she had suffered from an attack of men- ingitis, during which the vision of both eyes became affected, and has since grown slowly but steadily worse. She has been deaf in both ears for eight years, the cause being catarrhal inflammation of the middle ear, ex- tending from the naso-pharynx. The right eye began to protrude about one year ago, and the exophthalmos has slowly increased, but without any pain. When I saw her, the right eye protruded forwards and outwards, and was limited in motion in all directions. The iris was moderately dilated and immovable. The fundus showed a gray atrophic disc ; vision was sº. There was marked engorgement of the sub-conjunctival and episcloral veins. The cornca was slightly cloudy from old keratitis. In the left eye the cornea was still more cloudy, and the iris was dilated above the normal, and very sluggish. The optic disc was discolored on the tem- poral side, and the retinal veins looked engorged. Vision was ſº. There was no exophthalmos, and no limitation of motility. An examination of the naso-pharynx showed nothing abnormal beyond a general hyper- trophy of the mucous membrane. There was no trace of any growth. When the right eye was pressed backwards, a resisting mass was felt at the bottom of the orbit. A diagnosis of orbital tumor on the right side was somewhat hypothetical, and the patient was told she must await developments. The exophthalmos slowly increased, and vision slowly grew worse, but nothing absolutely certain was discovered until eight months had elapsed, when a growth was felt for the first time on the nasal side of the orbit. The patient was then told that an operation was necessary, and that the eye must be enucleated, and to this she consented. The eyeball was first removed in the ordinary way, great diſticulty being met with in cutting the optic nerve ; and on examining the eye after removal, the whole nerve was found to be enveloped in a dense fibrous mass, showing that the tumor had been cut through. The entire contents of the orbit, including the conjunctiva, were then removed, considerable dissection being necessary around the optic foramen. The periosteum was apparently healthy except at the apex of the orbit, where it was much roughened from the adhesions to the growth. The latter measured about three-quarters of an incli in length, and was roughly moulded to the shape TUMOR'S OF THE ORBIT. 117 of the orbit. The optic nerve passed nearly through its centre, and was de- cidedly flattened. The orbit was then washed out antiseptically, and bandaged in the usual way. There was no defect in the orbital walls, and no apparent prolongations of the tumor into any of the neighboring cavities. A careful examination of the growth after hardening, showed that it involved mainly the sheath of the optic nerve, the nerve itself being but slightly encroached upon. It could not be decided positively whether the tumor had originated in the sheath or in the periosteum of the orbit. It extended forward upon the sclerotic for a short distance, this membrane being intimately involved in the pathological process. Sections through the tumor, both longitudinally and transversely, showed it to be composed almost entirely of connective tissue bundles, the fibres being pressed closely together. In some places between the fibres were a few fusiform cells. The nearer the optic nerve was approached, the denser became the fibres. The cells in the perineural lymphatic space were increased in number and size. The optic nerve behind the eye, and within the tumor, was flattened, and showed signs of interstitial neuritis. The optic disc and the immediately surrounding zone of the retina showed the traces of neuro-retinitis, but the rest of the eyeball, with the exception of the cornea, was normal. The patient rapidly recovered, and has been carefully watched since, but no return of the tumor has been observed. An inter- esting feature in the case is the possible, I might almost say, the probable connection between the preceding meningitis as a cause, and the develop- ment of the orbital tumor, as the effect. We know that complications on the side of the eye are by no means infrequent during or after the menin- geal disease. The ocular complication is sometimes a purulent choroiditis, but more often it is a neuro-retinitis, with or without papillitis. It is by no means an improbable supposition that in the case just described, the intra-cranial inflammation extended along the membranes of the brain, in- volved the dural sheath of the optic nerve, and set up a hypertrophic vaginitis, which subseqently took on the form of a tumor of the optic nerve, or, more properly, of the nerve sheatlı, compressing the optic nerve, and producing the exophthalmos. CASE IX. On October 6th 1884, a young child, Jennie S., two and a half years old, was brought to me by the mother, who gave the following history : About a year before, after an attack of bronchitis, the mother noticed a small swelling at the inner angle of the left orbit, beneath the upper lid, which caused the lid to protrude. This was much less marked When the child was lying down than when she was in an erect position. It had grown somewhat during the year. There had been no other symp- tom. When I saw the child, there was a small circumscribed orbital growth at the upper and inner angle of the left orbit, beneath the upper lid, and outside the periosteum. When the child sat or stood, the protru- Sion occupied the region of the inner canthus, above the lachrymal sac, but When she lay down it receded almost entirely from view. It felt elastic, and I concluded it was an example of a retention-cyst of the orbit. The tumor was punctured through the cul-de-sac beneath the lid, and a quan- 118 MEW YORK STATE MEDICAL ASSOCIATION. tity of clear, straw-colored fluid escaped, and the cyst at once collapsed. I told the mother that the little tumor might return, but that the child was So young, it might be better to wait and see whether any more serious op- eration would be necessary. For nearly three months there was no return of the cyst; then it began to fill up again, and soon regained its former dimensions. The mother also noticed that when the head was bent for- ward, the swelling became much more prominent than ever before. I then determined to attempt the removal of the entire cyst, still regarding it as a retention-cyst developed in the orbital tissue. The upper lid was strongly everted, and the eyeball turned to the outer canthus, and held there by a strong suture passed through the conjunctiva on the nasal side of the cornea, crossing the cornea, and passing through the skin of the external canthus. The cul-de-sac was then opened at the inner canthus, and the cyst at once presented. It extended well up under the arch of the orbit, and far back into the orbit, but seemed to hug the inner wall. Its attachments to the orbital tissue were very slight, and easily broken, but on the side of the bone they were more firm, and in endeavoring to separate the cyst wall from one of these adhesions, the sac ruptured, and a large quantity of cloudy, yellowish fluid escaped. The cyst collapsed, and my finger passed into a large cavity. An examination showed that the orbital plate of the ethmoid bone and most of the lachrymal bone were absent, and that the ethnoid cells formed one large cavity, which communicated with the superior nasal meatus. This was proved by the fluid used in washing out the orbit and cavity in the bone passing down and out through the nostril. A drainage tube was then inserted. The little patient did very well. There was almost no suppuration, and the drainage tube was removed on the third day, and the child discharged on the eighth day. There has been no return of the disease, but there was rather a marked sinking in of the tissues at the inner canthus, and beneath the inner end of the orbit, so that there is a marked difference in the appearance of the two eyes. If there had been a carious process in the bone, which led to the disappearance of the inner wall of the orbit, there would almost certainly have been some general, as well as local, symptoms in the child during the process. For this reason I am more inclined to regard the case as one of congenital ab- sence, or arrest of development of the inner wall of the orbit, and the cys- toid development in the cavity of the ethmoid and orbit, as the result of a chronic catarrhal irritation of the nasal passages, perhaps connected with the bronchitis from which the child had suffered, CASE X. Early in November, 1884, I was called in consultation to see a gentleman, fifty-two years of age, and learned the following history of his case : For many years he had been a sufferer from lupus of the face, which had first appeared as a small nodule on the left ala of the nose. It slowly extended in several different directions, healing as it extended, until the cicatrix and the Sore covered a space as large as a silver half-dollar. It then remained quiescent for nearly two years, but subsequently extended upon the left side of the nose and orifice of the left nostril. During the past year its growth had been rather more rapid. When I saw him, the TUMC) RS OF THE ORBIT. 119. growth had entirely occluded the left nostril, filled the posterior nares, and extended over the cheek and molar prominence, and slightly into the Orbit. from the outside, pushing the eye upwards, outwards and forwards. It had also extended into the zygomatic fossa. The eyeball was still freely movable, and the axes of the two eyes could be made parallel, when the diplopia, which ordinarily existed, disappeared. Vision was normal, the media were clear, and the fundus was healthy. My opinion had been desired as to the advisability and feasibility of an operation, and I advised against any attempt to remove the external por- tion of the growth, on account of the great extent of diseased tissue, and the impossibility of procuring a flap of sound skin of sufficient size to close the wound. There also seemed a probability that the growth had extended from the nasal meatus to the maxillary antrum, and any attempt to remove this part of the growth would have necessitated the removal of the anterior bony wall of the antrum. The growth in the naso-pharynx might be removed, and this would render the patient much more comfortable and his respiration easy, and this I advised should be done. On November 13th the patient was etherised, and with some difficulty the left nostril and naso-pharynx were cleared of the growth, part being removed through the nostril and part through the pharynx. The septum nasi was found driven far over to the right side, and the growth had ex- tended up into the nasal cavity on the left side, beyond the reach of opera- tive interference. The immediate result was a great improvement in the patient's comfort, which remained for nearly six months, before his respi- ration became again obstructed. I declined any further interference on account of the hopelessness of the case. The progress of the disease was slow but steady. The whole left side of the face became gradually in- volved, the disease extending down to the angle of the jaw, over on the temple, and up on the forehead and bridge of the nose. The orbit filled up apparently from the orbital margin, and the eye was pushed forwards and inwards towards the nose; the eyelids became involved, the cornea ulcerated, and then perforated, and a large staphyloma developed and pro- truded between the swollen and half-closed lids. The patient lived for two years and a half after the operation, suffered greatly, and finally died from exhaustion. Throughout the entire course of the disease the progress had been from without inwards, and the resulting disfigurement was un- pleasant in the extreme. No autopsy was permitted, and thus no oppor- tunity was offered of determining whether there had been any change in the microscopical character of the growth. Before I first saw the patient, portions of tissue had been removed from the external growth on the nose, and had proved to be lupus. The portion removed from the interior of the nose had the mixed appearance of lupus and sarcoma. CASE XI. A little boy, R. P., three years of age, was brought to me in November, 1884, with the following history: About two weeks before, the mother had noticed a staring appearance of the right eye, which increased to a positive protrusion of the eyeball. When I saw the child, the lids were somewhat reddened, and the exophthalmos was directly 120 NEW YORK STATE MEDICAL ASSOCIATION. forwards. Pressure on the eye backwards gave an elastic sensation, and caused some pain. Inquiry developed the fact that the child had had some symptoms of congenital syphilis at birth, and that the father was undoubt- edly syphilitic. The case was watched for several weeks, but nothing abnormal was observed except a slow increase in the exophthalmos. The eyeball was apparently normal in every respect. I suspected the presence of either a cyst or an abscess, and advised an exploratory puncture. This was done, and a small trocar was passed into the Orbital tissue on the nasal side of the eye, but with no result. No trace of any growth could be felt in the orbit, and nothing was found in the nasal meatus or naso- pharynx. The exploratory puncture, however, seemed to set up a more active process in the orbit, for the exophthalmos rapidly grew worse, and the child began to complain of constant pain in the orbit. A more exten- sive operation was then proposed, and was consented to by the parents. The conjunctiva was opened horizontally on the temporal side, and the tendon of the external rectus muscle divided, and the eye turned strongly towards the nose. The finger was then introduced, and almost immedi- ately felt a tumor, which seemed to occupy the apex of the orbit, and to be firmly attached to the outer wall of the orbit far back. It had no ad- hesions to the eyeball, and was easily detached from the orbital tissue and sheath of the optic nerve, but was with great difficulty separated from the periosteum on the outer side of the orbit. In doing this the sac-wall was ruptured far back, and a quantity of ill smelling pus came out, and the tumor collapsed. The sac-wall was then carefully removed, as far as pos- sible, and the little finger being introduced, discovered a small patch of denuded bone far back on the outer wall of the orbit. There had evidently been a focus of periostitis, or perhaps of osteitis with caries, and an abscess had developed in the orbital tissue. The dead bone was scraped as thor- oughly as possible, the cavity thoroughly washed out with a sublimate solution (1–2000), and a loop of carbolised silk inserted for drainage. The case did remarkably well. Some suppuration occurred from the orbital tissue, and from the suture points which united the tendon of the external rectus to the sclera, but this ceased within the first week. The eyeball gradually receded within the orbit, and in two months scarcely a trace of the operation was left. There has been no return of the orbital trouble, but the child has had a rather severe osteitis in the right ankle joint, from which he eventually recovered. CASE XII. A young woman, K. M., twenty-one years of age, was brought to me on January 12, 1885. Three months before, she began to be troubled with epiphora in the left eye, and very shortly after, she noticed a small tumor along the orbital margin, just beneath the lower lid, and at about its middle. It was painless, and occasioned no annoyance. This has increased in size, and now begins to push the lower lid forward. On careful examination, the tumor could be plainly felt in the orbital cavity, lying along the floor of the orbit beneath the eye, and extending up slightly upon the inner wall. On being questioned, the patient stated that for more than a year she had suffered from a pain in the cheek, just beneath TUMORS OF THE ORBIT. 121 the orbital margin, which was dull in character, but never severe, and she had considered it a neuralgia. The teeth were examined, and several were found badly decayed, with large cavities. The nose and nasal meatus were also examined, but nothing specially abnormal found. A diagnosis was made of tumor of the orbit, with the possibility of its origin in the max- illary antrum, and subsequent perforation of the floor of the orbit. Both eyes were normal in every respect. The patient was advised to have the growth removed before the vision of the eye became affected, but declined all interference. In two weeks she came again, and a great change in her appearance had occurred. The growth of the tumor had been very rapid. The eyeball was displaced upwards and outwards, and vision was reduced to #}. The lids were swollen, and protruded perceptibly. The growth covered the floor of the orbit, extended over the inner wall, involved the orbital plate of the ethmoid, and had spread over the lower edge of the orbit, and down upon the anterior surface of the superior maxilla. She was then eager for an operation, although she was told that in all proba- bility the eye could not be saved. The nose and the pharynx were again carefully examined, but nothing abnormal was found. On January 30th, I enucleated the eye, and then found that nearly the whole orbit was filled with the growth. It varied in consistency, being in some places hard, and in others soft. In examining the floor of the orbit, the probe passed into a cavity, showing that a communication with the antrum existed. The orbit was then thoroughly cleaned out in the usual way, when a large opening was discovered in the floor of the orbit, which extended nearly to the orbital margin, and the growth could be seen and felt in the antrum. The extra-orbital portion of the growth was then removed from the surface of the upper jaw, and was found closely united with the periosteum. The antrum was then emptied of its contents, and an examination showed that the growth had not apparently extended into the nose. The cavity of the antrum and the orbit were then carefully washed out with bichloride Solution (1–2000), and the surface of the periosteum thoroughly scraped and cauterised. The patient recovered rapidly, and went home at the end of two weeks. She was told that the tumor would almost certainly return, and that she must be seen at short intervals. I did not see or hear of her for nearly a year, and then she came with a return of the growth just be- neath the lower margin of the orbit, on the superior maxilla. There was no sign of the recurrence of the tumor in the orbit, and the antrum was empty, except for a considerable amount of thick, glairy mucus. The pain in the upper jaw had appeared at intervals, but had not lasted long. The external growth was removed through the lower cul-de-sac, the latter being incised throughout nearly its entire length, and the lid depressed. After the nodule had been dissected out, the bone was thoroughly scraped, and then cauterised with the actual cautery. Considerable suppuration fol- lowed this operation, and the lid remained everted for several weeks, but eVentually this defect entirely disappeared. I saw this patient at intervals for several months, but she then disappeared, and I have heard nothing of her since. The growth in the Orbit, on microscopical examination, proved 122 NEW YORK STATE MEDICAL ASSOCIATION. to be of a mixed nature. The denser portion of the tumor was pure sar- coma of the small-cell variety ; the softer portion, together with the growth in the antrum, was myxo-sarcomatous in character. It was impos- sible to decide, from an examination of the tumor, and of the orbit and antrum, where the disease originated, though the combined evidence was rather in favor of the antrum. CASE XIII. Early in March, 1885, a man, C. K., twenty-eight years of age, came to me with a very incomplete and fragmentary history of trouble in the orbit, on the left side. There had been a dull pain in the orbit and left side of the head for some months, which was constant, but never severe. Lately there had been some failure of the vision, and some prominence on the eyeball. He had had two decayed teeth removed, one from each jaw of the left side, but the pain continued. An examination showed a very slight prominence of the eyeball, with W-##, clear media, and a normal fundus. On the inner side of the left orbit, far back, a slight elastic prominence could be felt. The naso-pharynx was examined, but beyond a chronic catarrhal condition with rather profuse secretion, nothing abnormal was discovered. The pain was now confined to the supra-orbital region and root of the nose. There seemed nothing to do but to watch the patient and await developments. One month later there was apparently a slight increase in the elastic prominence on the nasal side of the orbit, and a small trocar being introduced, a little yellowish, turbid fluid was evacuated. During the next day it dribbled through the wound and beneath the conjunctiva. That night the patient slept well, but towards morning he woke up with a feeling of a severe cold in his head. In en- deavoring to clear his nose he made several violent expiratory efforts, and finally a quantity of gelatinous material was discharged through the nos- trils, and he felt as if something had “given way in his eye.” He came to See me early in the morning. The discharge was still coming from the nose, and the ocular conjunctiva was swollen, and distended all round the cornea, as in a case of extreme chemosis. The diagnosis was now some- what easier. As a consequence of the chronic nasal catarrh, there had been an accumulation of fluid in the upper nasal meatus, ethmoid cells, and probably in the frontal sinus. As a result of the pressure, either one of the fissures in the Orbital plate of the ethmoid had been widened, or the bone itself had been worn away, thus forming a communication with the Orbit, and the development of an apparent cyst in the orbit. This was punctured, and the contents flowed out beneath the conjunctiva. The violent expiratory effort had produced an enlargement of this opening in the ethmoidal plate and the discharge of a large quantity of fluid into the orbital tissue, as well as through the nose. I punctured the conjunctiva in several places, and had the eye and conjunctival cul-de-sac irrigated every two hours with a sublimate solution (1–5000), while the naso-pharynx was frequently washed out with a Saturated solution of warm potassium chlorate. The patient recovered without an adverse symptom, and vision was gradually restored to the normal standard. TUMC) RS OF THE ORBIT. - 123 CASE XIV. In the latter part of September, 1885, a gentleman, fifty- eight years of age, came to me with the following complaint : In October, 1884, he began to have a dull pain in the left side of his face, near the ex- ternal angle of the right eye, and over the molar prominence, which lasted for some months. Thinking it might come from the teeth, he consulted his dentist, who extracted the third and fourth molars from the upper jaw on the right side, as these were badly decayed. The fangs of the fourth molar had penetrated the antrum. For more than a month after the re- moval of the teeth, there had been a slight offensive discharge into the mouth from the alveolar opening into the antrum ; then this ceased, and was followed by a more or less profuse purulent discharge through the right nostril and into the pharynx. The dull ache over the molar promi- nence still continued, and was supplemented by pain in the region of the right frontal sinus. In June, 1885, the right eye was noticed to be on a higher level than the left eye, and to be somewhat more prominent. He consulted an oculist in a neighboring city, who told him that there was a tumor in the orbit, and that the eye must be removed. There was at this time no impairment of vision, but during the summer he began to have vertical diplopia. When I saw him there was a slight difference in eleva- tion of the two eyes, but no exophthalmos, and the right eye could be moved freely in all directions. Shortly after his first visit, the purulent discharge from the nostril, which had been very slight for some months, became again profuse, and the right eye was restored to its normal posi- tion, and the diplopia almost entirely disappeared. This induced me to believe that the tumor was entirely in the antrum, and was in the nature of an abscess, and I urged an operation. To this the patient objected, as his condition was very comfortable, and the frontal pain had subsided. I did not see him again until March, 1886. At that time the discharge from the nose had nearly ceased, the right eye was displaced decidedly upwards and somewhat outwards, and distinctly protruded from the orbit. The diplopia was more marked than ever, and the pain over the molar bone and frontal sinus was at times severe. The naso-pharynx showed little abnormal. Vision in the right eye was still perfect, and the ophthal- moscope gave a negative result. Influenced by my experience with a former, very similar, though less severe, case, which I had transferred to the care of a general surgeon, who operated on the patient with excellent results, I urged an operation on the antrum through the mouth, and to this the patient consented. The alveolar opening at the root of the fourth molar tooth still existed, though closed by mucous membrane. This I enlarged with small bone forceps, first dissecting away the mucous membrane and gum. This was followed at once by the discharge of an immense quantity of apparently healthy pus. The antrum was then irrigated with a warm saturated solu- tion of boracic acid, the irrigation being continued until the fluid returned °lear. The cavity was then filled with a solution of sublimate (1–5000), and the opening temporarily plugged. The nose and orbit were next care- fully examined. Some of the fluid in the antrum escaped through the 124 JNETW YORK STATE MEDICAL ASSOCIATION. nose. The floor of the orbit, which had been pushed upwards, had re- ceded, and proved to be excessively thin, but apparently unperforated. The plug was then removed from the alveolar opening, the sublimate Solu- tion allowed to run out, and the antrum again irrigated several times with the boracic acid solution. The result was extremely satisfactory. There was no reaction, and the patient rapidly recovered. A thin, semi-purulent discharge continued for about two weeks, but the cavity was washed out daily, and at the end of the second month the patient was discharged cured. CASE XV. About the middle of May, 1886, agentleman, thirty-two years of age, consulted me in regard to one of his eyes. About six months be- fore, he had noticed a small nodule at the inner canthus of the left eye, which at first looked like an enlargement of the caruncle. This slowly increased in size until it projected outside the canthus, between the edges of the closed lids. While in Europe he consulted a surgeon, who removed the growth, together with the caruncle. It returned within two months, and increased rapidly in size, occasioning great discomfort. When I saw him the growth involved the entire inner canthus, including the conjunc- tival folds, the ocular conjunctiva as far as the corneal margin throughout its nasal half, and both culs-de-sac, and had extended deeply into the orbit along the inner wall, being apparently closely connected with the perios- teum over the lachrymal and ethmoid bones. The inner ends of both lids were also infiltrated. The eye was limited in motility in all directions except outwards. The media were clear, the fundus healthy, and vision was normal. I advised a very complete and radical operation, viz.: the enucleation of the eye, the removal of the entire contents of the orbit, including the periosteum if necessary, and of the inner halves of both lids. To this the patient would not consent, and went home, but subsequently submitted to an operation by a local surgeon, the exact nature of which I do not know, but it included the enucleation of the eye. The tumor again returned within two months, and grew with great rapidity, so that less than four months after the second operation, when he again consulted me, the growth had filled the orbit, involved nearly the whole of both lids, the cheek, the side of the nose, and temple. The left nostril was also oc- cluded, though by what could not be ascertained definitely, but probably by a prolongation of the growth from above. Inasmuch as nearly all the deep bones of the face were involved, as well as the adjacent cavities, I declined to operate, but removed a piece of the orbital growth for examination. The patient returned home, and a fourth operation was done, but he died within two weeks, of exhaustion. The microscopical examination of the portion of orbital growth removed, proved it to be a small-cell sarcoma. I subsequently learned that the family history of the patient on the mater- nal side showed a distinctly cancerous tendency. His mother had had a cancerous breast removed, and had subsequently died of a return of the disease. A maternal aunt had died of cancer of the uterus, and so had his maternal grandmother. TUMORS OF THE ORBIT. 125 CASE XVI. In the latter part of December, 1887, a little boy, three years of age, was brought to me. His case proved to be one of great inter- est. About fourteen months before, the child had received an injury to the left arm from a fall. The exact nature of this injury I could not as- certain, but it was not a fracture. From this there resulted a tumor, which involved the left upper arm, from the elbow to the head of the humerus, and the glands of the axilla were infiltrated. Sometime during the summer of 1887, the left arm was amputated at the shoulder-joint, and the enlarged glands were removed from the axilla. The mother said that the tumor, on examination with the microscope, proved to be a Cancer. Soon after the amputation of the arm, the right eye was noticed to be more prominent than the left, and the upper lid drooped. When I first saw the child, the exophthalmos was forwards, downwards and outwards, and the infiltra- tion of the lid was marked. The evidence of the presence of an orbital tumor was unmistakable, and the parents were told of the probable malig- nancy of the growth, and of its connection with the tumor in the arm. The presence of the same trouble in the lid was inferred from its swollen, infil- trated condition, and the hard sensation it gave when compressed between the fingers. I advised that the orbit be emptied of its contents, including the eyeball, that the upper lid be removed, and that the orbit be closed up by a plastic operation. This advice was declined, and I heard nothing of the child until four weeks later, when the father informed me that the child was ill with pneumonia. Death followed on the third day, and I re- ceived permission to remove the contents of the orbit, including the eye- ball. The tumor had grown very rapidly, and was closely adherent to the periosteum, and to the sheath of the optic nerve, so that the eye and the tumor were removed together. The growth had also extended into the sphenoidal fissure and over on the cheek. It proved to be a very was- cular small-cell sarcoma, arising from the periosteum, and involving in its growth the sheath of the optic nerve, the intravaginal lymphatic space being filled with small round cells, similar to those in the main growth. Nome of the tissues of the eyeball itself was invaded by the growth. I was not permitted to make any further examination of the body CASE XVII. I was consulted in March, 1889, by a gentleman, aged forty, who told me that the vision of the right eye had been defective from early childhood, although it could be somewhat improved by glasses, which he sometimes wore. Three months before, vertical diplopia suddenly ap- peared, preceded by a severe pain in the left eye, and the double vision had persisted ever since. He thought also that the left eye was somewhat more prominent than it had been. For the last six weeks the upper lid On the left side had been swollen. When I saw him, the left upper lid was turgid and seemed pushed downwards. The left eye protruded forwards, downwards and outwards, but the motility was not greatly impaired ex- Cept upwards. The media were clear and the fundus was normal in both eyes. There was diplopia upwards, and to the right, for all large objects. R. E. º. : with cyl.-D. 2.75 axis 90° = #} : L. E. #} : with cyl- D. 0.50 axis 90° = #4. Just beneath the superior orbital margin on the 126 NEW YORK STATE MEDICAL ASSOCIATION. left side, near the inner angle of the orbit, and reaching nearly to the outer angle of the orbit, was an elastic, nodular mass, extending backwards for some distance, and apparently closely connected with the roof of the orbit. The naso-pharynx was normal, as was also the orbit on the oppo- site side. The patient was told that he had an orbital tumor, and that if an operation were done at once for its removal, the eye might be saved. He consented, and the operation was appointed for the next day. The location of the tumor was such that it was necessary to displace the eyeball downwards and outwards as far as possible, and this was done without dividing any of the ocular muscles. The conjunctiva was divided through the upper cul-de-sac, the incision extending the whole length of the superior orbital margin. The adhesions between the orbital tissue and eyeball, and between the latter and the tumor, were then carefully broken through with the finger and a strabismus hook, which was easily done, as none of the adhesions were firm. It was then found that the tumor in- volved nearly the entire roof of the orbit, and extended as far back as the finger could reach. It was flattened in the centre by pressure of the eyeball, but was thicker on the temporal and nasal sides. It was very firmly attached to the periosteum of the roof, and its dissection was ex- tremely tedious. Great care had to be exercised to avoid wounding the pulley of the superior oblique; and at the apex of the orbit, to avoid in- jury to the optic nerve, superior oblique and superior rectus muscles. After its removal, as much of the periosteum of the roof of the orbit as could be reached was stripped off, and the underlying bone scraped. The cavity was then thoroughly irrigated with a sublimate solution (1–2000), the wound in the cul-de-sac carefully closed by a number of sutures, and the eye bandaged. There was scarcely any reaction, but the infiltration in the upper lid subsided very slowly. At the end of a week the eyes were tested for diplopia, and it was found that the Superior oblique had been injured during the operation, the relation of the double images to each other being quite characteristic. This persisted for more than four months, but eventually almost entirely disappeared. The eyeball resumed its nor- mal position but slowly. This patient is still under observation, being seen at somewhat long intervals, but there has been as yet no trace of a recurrence of the disease, a period of three years and a half since the operation. The tumor was very carefully examined, and proved to be a fibro-Sar- coma, with a very large preponderance of dense fibrous tissue, and but comparatively few cells, which were of the fusiform variety. w CASE XVIII. Early in April, 1889, a man was sent to my office with the following history: He was twenty-three years of age, and apparently in per- fect health, with unusually fine muscular development. Five or six weeks before, he had first noticed a small lump in the lower lid of the left eye, near the inner canthus. It was at first movable and painless, but increased rapidly in size, became painful, and led him to seek advice. When I saw him, the lower lid was swollen, reddened, and partially everted. The TU MORS OF THE ORBIT. 127 growth had extended downwards and outwards over the superior maxillary and malar bones, and backwards into the orbit, along the floor and inner wall. It was irregularly nodulated, and the skin was freely movable over it. The left eye was limited in motility inwards and downwards. Both eyes were normal in every respect. It was impossible to determine by examination whether the growth had begun in the Orbit or eyelid. I gave an unfavorable prognosis, and told him the only advice I could give him was to have an operation done for the removal of the tumor as soon as possible, and that it would necessitate the loss of part of the eyelid, and possibly of the eye itself. He agreed to do whatever I advised, and the oper- ation was done on the second day following. The internal canthus was split by a horizontal incision, extending to the bridge of the nose. The lower lid was then split into an anterior lamina of skin and orbicular muscle, which seemed to be healthy, and a posterior lamina containing the tarsus, connective tissue and conjunctiva, as in the old Arlt-Jaesche opera- tion for entropium. The incision was carried from the outer end of the horizontal incision outwards to the middle of the lid, and then extended vertically downwards to the level of the lower margin of the orbit. This was done because the skin of the lid seemed healthy. The ocular conjunc- tiva was then dissected free from the nasal half of the eyeball, being cut en- tirely across along the lower orbital margin and inner side of the orbit, and turned over on the cornea. It was then seen that to reach the extra-orbital portion of the growth the lower lid must be divided vertically down to the lower orbital margin, which was done, and the halves of the lid turned as far as possible out of the way. The growth was not very adherent to the underlying bone outside, and was easily removed by the Scissors and forceps. Inside the orbit it was more flattened out and adherent to the bone, especially along the floor of the orbit, and here the process of dissection was much more slow. It extended about two-thirds of the way back into the orbit, was closely attached to the periosteum, but not at all to the eyeball, which was readily pushed out of the way. After nearly an hour's work, the tumor was apparently entirely removed, and a careful examination was then made of the floor and inner wall of the orbit, without discovering any remains of the growth. The bone was then scraped, and the cavity in the orbit washed out with a solution of mercuric bichloride (1–5000). The inner half of the lid, consisting of skin and muscular tissue, was then cut away and removed, and the vacancy filled by a flap of skin taken from the fore- head and root of the nose, twisted on its base, and united with the inner end of the outer half of the lid by suture pins and the necessary sutures. There was considerable reaction on the next three days, but almost no sup- putation, and the flap healed well, so that the patient was discharged from treatment in about five weeks, with a very presentable lower lid. Nothing more was heard from the patient for a period of eight months, when he presented himself with an unmistakable return of the growth in the orbit and eyelid. A very radical operation, including the removal of the eye- ball, was the only advice I could give him, and this he declined. Nearly a year later an operation was done in a distant city for the removal of the 128 JNETW YORK STATE MEDICAL ASSOCIATION. growth which had attained enormous proportions. The nature of this opera- tion was unknown to me, but it involved the removal of several large pieces of bone, probably the superior maxilla and ethmoid. He recovered from this operation, but died soon after from some cerebral complication, and an autopsy was not allowed. The tumor removed by me at the first operation contained but very few blood-vessels, and proved to be a sarcoma of the spindle-cell variety, with considerable fibrous tissue scattered through it. CASE XIX. On October 4, 1889, a woman, thirty-five years of age, was brought to me with the following history : For about a year she had suf- fered from Severe neuralgia in the right side of the head and right orbit. She had had defective vision in both eyes for four or five years. Four days before I saw her, she suddenly discovered that she was blind in the right eye. An examination showed the following condition : The right eye pro- truded straight forwards, and its motility was limited in all directions. It resisted any attempt to replace it in its normal position, and any such attempt was very painful. The iris was dilated and immovable. The right eye protruded a quarter of an inch in advance of the left eye, but in the same horizontal plane. There was an apparent infiltration of the orbital cellular tissue, which was most marked along the floor of the orbit, and upwards and outwards just inside the superior orbital margin. There was a chain of enlarged glands on the right side, beginning at the pre-auric- ular gland and extending down along the border of the sterno-cleido-mas- toid muscle to the level of the thyro-cricoid region. The patient had had repeated epistaxis for some months, together with a profuse purulent dis- charge from the right nostril. An examination of the nose revealed an hypertrophied and displaced inferior turbinated bone, but no visible growth in the naso-pharynx. The patient complained of a constant pain over the malar and superior maxillary bones. A diagnosis was made of a tumor in the nasal meatus, orbit, and maxil- lary antrum, with the strong probability of its origin in the antrum. Two weeks later the growth along the floor of the orbit appeared at the inner Canthus, where it felt like a hard though slightly yielding mass, and I urged an immediate and radical operation. The right eye was entirely blind ; the ophthalmoscope showed a neuro-retinitis or papillitis, in the stage of atrophy. . The family consented to an operation, which was done on October 9th. So far as could be discovered, there was no external growth on the cheek. The eyeball was enucleated in the usual manner, and the posterior part of the Sclera and sheath of the optic nerve was found to be surrounded and intimately connected with the growth in the orbit. On cutting through the Optic nerve, a mass of the tumor was cut through and came away with the eyeball. The floor of the orbit was found entirely absent, except a narrow rim of bone along the orbital margin, and the antrum was filled with the growth. The conjunctiva was then cut through at the culs-de- sac, and with the entire contents of the orbit was then removed. The TU MORS OF THE ORBIT. 129 inner wall, roof and outer wall of the orbit seemed to be intact, and the periosteum was smooth. The growth did not appear to extend into the optic foramen or sphenoidal fissure, and these facts seemed to emphasise the probability that the tumor originated in the antrum. The communica- tion between the antrum and nasal meatus was found much enlarged. The growth was removed from the antrum, and the cavity thoroughly washed out with sublimate solution (1–5000). Part of the inner wall of the antrum and part of the nasal process of the Superior maxilla were then removed, and the growth was cleared out from the nasal meatus. Small pieces of the tumor and bits of the turbinated bones were removed in this way, until it was possible to syringe freely from the antrum into the nose and pharynx. A large amount of detritus was washed out in this manner, until the lower and middle meatus were entirely free. A drainage tube was then introduced through the nose, and the orbit dressed in the usual way. The bony walls of the antrum seemed to be intact, except the roof, which was entirely gone. In view of this fact, I did not deem it wise to attempt the removal of the maxillary bone, as the patient was greatly prostrated by the long operation. I told her family that the tumor would probably return, and in a comparatively brief space of time; but in this I was mistaken. The patient recovered rapidly from the effects of the operation. The orbit and antrum were irrigated twice daily for a period of three weeks, but there was not at any time much discharge, and it soon changed into a slight mucous secretion. At the end of two months, the periosteum lining the antrum and orbit looked smooth and normal, and the patient could breathe through the right nostril. There was no positive evidence of a return of the growth till the November following, a period of thirteen months. It then appeared in the nose from above, extending downwards into the nostril, and also through the enlarged opening into the antrum. She began to complain of severe frontal headache, which probably pointed to an extension of the growth into the frontal sinus or ethmoid, or both. I advised another operation, beginning in the nose, but did not urge it Very strongly, as I regarded the case as hopeless from the first, and the patient herself did not wish it. I watched the case to the end. The growth gradually filled the antrum and orbit, extended into the ethmoid, broke through the orbital plate of the ethmoid into the orbit, and also filled the sphenoidal fissure. The growth in the nose was so extensive as to obliterate both nasal cavities, and for the last months of her life, she breathed entirely through the mouth. She finally died from pure exhaus- tion, without any further head symptoms, nearly two years after the op- eration. Her family would not allow an autopsy. The tumor, on examination, proved to be a very vascular small-cell Sarcoma, which had intimately involved the sclera and sheath of the optic nerve, as Well as all the orbital tissues. PARAPLEGIA. By CHARLEs W. BROWN, M. D., of Washington, D. C. November 16, 1892. On March 2, 1892, I was called to see D–, a single man, twenty-three years of age, a steam-fitter by Occupa- tion. He had a good family history, and had never had syphilis; previous to last February had always been healthy. Early in February he contracted gonorrhoea, and was treated by a homoeopath, without particular benefit. On February 7th, while at his work in Charles- ton, S. C., putting a covering on a steam boiler, he sat upon the cold steel for the greater part of three days, and each night before retiring, he had a chilly sensation along his spine, followed by pain in his back. The third night he had a decided chill, lasting for half an hour, but he slept well all night, and the following day went to his work as usual, but said his legs felt numb, and he was obliged to make an extra effort to step over any object. He made an attempt to climb up a short ladder to get to his work, and could not raise his feet sufficiently to do SO. He worked about the steamer all day, and walked to his boarding-place in the evening. The next morning he was unable to pass his urine, and there was loss of sensation in both legs; but he could walk about the room, with the aid of a chair, and looking at each step to see where he placed his feet. A surgeon was called, who emptied the bladder by means of a catheter. On the fifth day after the numbness of the limbs commenced, there was complete paralysis below the last dorsal vertebra, and he was unable to move a muscle of either leg. He was brought to his home in Washington the sixth day after he had the chill, and I saw him first on that PARAPLEGIA. 131 day. His temperature was 104.5°, pulse 110, very weak and small; he was not delirious, but despondent. There was some swelling over the lower portion of the spine, but no tenderness when firm pressure was made, at, and above the line of paralysis. He suffered no pain, but complained of a dragging Sensation, and of constriction about the waist. Above the waist the power of move- ment and the power of sensation were natural ; below the waist, all the voluntary muscles were entirely para- lysed, and the sensibility to pain, to tickling, to differ- ences of temperature, as well as to touch, were com- pletely lost. Pressure along the spine was felt above, but not below the point to which the anaesthesia reached, and firm pressure was borne without wincing. The feeling of warmth produced by passing a sponge soaked in hot water along the spine, was felt above, but not below, the point to which the anaesthesia reached ; and at the line of junction between the sensitive and the paralysed parts, this feeling amounted to a burning. The Same burning sensation was produced by passing the Sponge around the body in the course of this line of junction. No reflex movements were produced by tick- ling the soles of his feet ; though when the clothing was Suddenly thrown off his legs, the current of air produced a slight reflex, the spasms of the muscles being sufficient to be noticed by the patient. The application of an electric current over the area of anaesthesia, produced no reflex; he had no control of his bowels or bladder; there was no priapism during the time the paralysis continued ; the gonorrhoeal discharge Was considerable; the introduction of the catheter pro- duced no pain. There was a large bed-sore over the left side of the sacrum, extending down on the nates. The urine was alkaline, and had a strong ammoniacal odor. His legs and feet were cold and oedematous. Although the urine was drawn by the catheter at least four times every twenty-four hours, there was a persist- ent cystitis, which lasted for several weeks after he was 132 NEW YORK STATE MEDICAL ASSOCIATION. able to walk. Mucus and pus came through the Catheter in considerable quantities, and clogged the instrument So that it was necessary to wash out the bladder nearly every day for two weeks. On the day of his arrival home, dry heat was applied to his feet and legs, by means of heated woolen blankets, and rubber bags of warm water. The nurses were cautioned to be careful about burning him, but in Spite of this warning, his father placed a two-quart bag filled with very hot water near the soles of his feet, and during the night in some way, the blanket which was placed between the bag and his left foot, was taken out, and at my morning visit, I found the sole of his left foot com- pletely cooked from the heel to the end of the toes, and when the slough came off, three weeks later, it exposed the periosteum over a portion of the OS calcis, and the first and second metatarsal bones. When the surface became covered by healthy granulations, numerous skin grafts were applied, and on July 15th, the ulcerating surface was completely healed over, with but little contraction of the cicatrix. The gonorrhoea was treated by the usual means, and in two weeks the discharge had ceased, and simulta- neously there was the first slight return of Sensation in the right foot and leg. On March 16th he could feel the prick of a pin on most all the surface of both feet and limbs. By the middle of April he was able to move the toes of his right foot slightly, and from day to day the improvement in motion continued, so that by May 10th he was able to stand upright and walk about the room by the aid of crutches. Since July 1st he has walked without assistance, and from the middle of July has done his usual work, his principal difficulty being with the bladder. At times he cannot pass his urine, and then there will be a few days in which the urine drips away. I saw him a few days since, and he said he had had but little difficulty in passing urine during the last ten days. During the second week after the case came under my PARAPLEGIA. 133 care, the temperature ranged from one to two degrees below the normal. I quote the following from Reynolds's System of Medi- cine, Vol. I., page 964: “Acute myelitis affecting any considerable extent of the spinal cord is, without doubt, a very grave disorder. It may be fatalin fifteen or twenty hours, and it is seldom that life is prolonged beyond the end of the second week. Instances of recovery are On record, it is true, but these are very few in number, and of them there is, perhaps, no single one in which the correctness of the diagnosis may not be impugned. Even chronic myelitis is a very grave disease; for though life may be prolonged, especially where the disease is confined to the lower part of the cord, the mischief once done seems to be in a great measure ir- reparable. At the same time it is only right to say, that of late years the results of treatment have been much more satisfactory, and that it is possible now to hope where there was little room for hoping formerly.” From this it would seem doubtful whether this was a case of myelitis or not, though the symptoms would cer- tainly indicate it. The question of whether the gon- orrhoea was a factor in the production of the paralysis is important. Brown-Sequard says: “Paraplegia may also be the result of disorder or disease, beginning at a distance and affecting the cord secondarily, beginning in the urinary and genital organs more especially; of this there can be but little doubt. The chief characteristics of that form of reflex paraplegia which is associated with disease of the urinary organs is urinary paraplegia, as it is often called. Usually the paralysis is incomplete, both as to degree and extent, some muscles being obviously more af- fected by it than others; usually the paralysis is not asso- ciated either with tingling, or numbness, or anaesthesia; usually the bladder and rectum are only slightly impli- Cated in the paralysis.” He also says: “Reflex par- aplegia differs diametrically from the paraplegia produced 134 NEW YORK STATE MEDICAL ASSOCIATION. by myelitis. In paraplegia from myelitis, the paralysis is usually complete, and all the muscles are affected equally; not so in reflex paraplegia. In paraplegia from myelitis, the paralysis is associated with tingling, numb- ness, or anaesthesia ; not so in reflex paraplegia. In paraplegia from myelitis, paralysis of the bladder and lower bowel is a marked phenomenon ; not so in reflex paraplegia. In paraplegia from myelitis, cure, or even improvement, is the exception ; in reflex paraplegia it is the rule.’’ - DISCUSSION. DR. H. S. WILLIAMS, of New York county, said that he had been greatly interested in the case described in the paper, and agreed with the author that it was one of myelitis. He had seen recently a case, which proved that the symptoms of myelitis are not so pronounced in some instances as is commonly supposed. Its onset in his case was not unlike that described by the author, and it terminated fatally in less than a week. During this time, there was no marked impairment of sensibility, nor was there a sign of paraplegia, as commonly described, and, therefore, the diagnosis of myelitis had not been made ; yet the autopsy showed unequivocally that this was a case of myelitis. The lumbar cord was chiefly affected. He had been especially interested in the case, as showing to what extent micro- scopical changes might occur, without affecting the transfer of the current both above and below. DR. BROWN, in closing the discussion, said that the treatment of his patient in the early or acute stage, consisted in the administration of nux vomica and the application of electricity, with attention to the condition of the bowels and general health. Iodide of potassium was used after the acute stage had passed. THE QUESTION OF MATERNAL IMPRESSIONS. By H. S. WILLIAMs, M.D., of New York County. (Read by title November 16, 1892.) In asking your attention to the mooted question of so- called maternal impressions, I shall attempt no elaborate or comprehensive discussion. I desire merely to glance at the matter from a point of view which is usually neg- lected. I will not take your time with an analysis of alleged cases in point, but will at once assume that, inas- much as equally competent observers draw radically dif- ferent conclusions from these cases, they cannot properly be regarded as demonstrative. This definite assumption is necessary at the outset, because if a single unequivocal case were on record, our discussion need go no further. Science knows nothing of rules proved by exceptions. But I know of no such case, and therefore assume that, as regards the teaching of experience, the subject is still subjudice. It seems at first thought a little strange that this should be so, when one reflects that the question has been, in a sense, on trial every time that a new being has been born into the world since the race was young ; but this is really another way of saying that the problem is an extremely complex one. In truth, it does present a Vast number of points for mistaken inference, and its difficulties, as regards the application of rigorously sci- entific tests, are very great ; and while I do not think these difficulties insurmountable, I believe they have not yet been surmounted. Hence, I feel justified in appeal- ing to philosophy for an opinion, on a topic which induct- ive science must ultimately settle. The question before us is briefly this: In what meas- ure, if at all, may mental states of the mother oper- ate to alter the potentialities which enter into a new being at the moment of conception ? This is, I believe, the 136 WEW YORK STATE MEDICAL ASSOCIATION. question of maternal impressions, as usually considered. But a moment's consideration will show that the ques- tion as thus stated really involves two radically distinct Questions: (1) To what extent may mental states of a mother affect the foetus indirectly 7 (2) To what extent may they affect it directly The first of these questions, I desire to entirely exclude from the present discussion. It is an interesting topic in itself, and one worthy of more careful investigation than has yet been given it, but it is not pertinent to my present purpose. How much, or how little the foetus may suffer from nutritional changes of the mother, from toxic con- ditions of her blood, or from uterine anomalies, even when these conditions result from mental states, does not here concern us. The question which I wish to consider briefly is: May mental states of a mother be directly transferred, as such, with energising force to the foetus? This is the real pith of the question of maternal impres- sions. However much the other extraneous elements may enter into it; however much, for example, nutri- tional alterations may be referred to, it is always alleged or implied whenever a supposed illustrative case is cited, that an element of direct mental transfer underlies the other conditions, and is, indeed, the essential element of the question. I shall now consider only this alleged es- sential element. For convenience, I shalluse the general term “maternal impressions,” but bear in mind that I intend it always in this restricted sense. It needs no argument to show that a belief in maternal impressions has been widely prevalent for centuries. It was, perhaps, more generally accepted in the past than at present, but it is by no means obsolete to-day ; in fact, thousands of intelligent persons, lay and profes- sional, still believe in it implicitly. The illustrative cases which are cited in its favor, have, for the most part, been drawn from the human race, but alleged cases among the lower animals are not wanting—e. g., the famous case recorded in Genesis, of the striped MATERNAL IMPRESSIONS. 137 Sticks and the spotted sheep. Among moderns also, the belief is generally applied to lower animals as fully as to the human race, and this application is strictly logical. The great merit of modern biology is that it has taught us to look on every organism as a member of an endless series of organisms, all subject to the same general laws, which are relatively few in number, but of universal scope. We know of no innate organic capacity which has an important bearing on organic development, which is confined to any individual, species, or family. Now, this capacity of mental transfer from mother to foetus, if it exist at all, is certainly of far-reaching importance from the standpoint of the evolution of the race; hence, we are forced to conclude that, if it operates at all, it is not confined to any single race of beings, and since the scale of development is a theoretically unbroken one, it is impossible to mentally fix upon any particular stage of organic evolution at which this capacity became opera- tive. If, then, this capacity exist at all, it must be regarded as a general law, which though variously modified in detail, operates upon every race of organ- isms in the world. I think we cannot logically escape this conclusion ; and hence, it becomes evident that the alleged transfer of maternal impressions is not merely an individual question, possibly of practical significance to a few hundreds of the human race, in any generation, but a far-reaching capacity, which, if it exist at all, must necessarily influence the development of the entire Organic system. We are viewing an alleged general bio- logical law, and we may, therefore, properly consider the question in the light of such known laws of develop- ment as are pertinent, endeavoring to decide how far the alleged law of maternal impressions is in harmony with these known laws. To this end I shall emphasise certain familiar biological truths, which it is important to our discussion should be borne prominently in mind. It is a familiar biological axiom that the chief function of any Organism is to reproduce its kind. Everywhere 138 NEW YORK STATE MEDICAL ASSOCIATION, above the protozoa, this reproduction is accomplished by the union of male and female elements, each representing in some mysterious way the potentialities of the being from which it springs. The moment these elements unite, a new and independent being is produced. The details of this union are not essential ; it may take place in the water, as in the case of a fish, or within the genital canal of the female, as in most higher Organisms; the result is uniform. The act of paternity renders the male parent obsolete, but the mission of the mother is not yet complete. The new being is at first absolutely helpless, and Nature decrees that the mother shall aid it ; shall shield it for a time, as far as may be, from the adverse forces of the environment. The essence of this aid is the Supplying of nourishment to the young Organism. The new being may be placed in a lake of nutritious matter, called an egg, and soon extruded into the outer world ; or it may be supplied piece-meal with this nourishment, being retained meanwhile within the maternal organism. In each case the new organism is equally dependent upon the maternal organism for its nourishment; equally inde- pendent as an individual entity. The expulsion of the new being from the genital canal of the mother, may take place, as in case of the fish, even before the new being comes into existence ; it may occur before develop- ment has advanced beyond the first stage, as in the bird and the lowest mammal; it may be accomplished when the new being is further advanced, but still utterly helpless, necessitating the employment of what might be termed “a supplementary external uterus,” as in the marsu- pials ; or it may be delayed until the new being has ad- vanced far on the developmental road. These differences are minor details of specific adaptation ; the underlying law is everywhere the same, viz.: The maternal organism must strive, at whatever hazard, to protect the new being until it is able to battle for itself. To that end, her in- stincts are changed ; she passes to a new stage of mental evolution ; the law of self-preservation is supplanted by MATERNAL IMPRESSIONS. 139 the law of race preservation, and for the first time in the history of mind, a truly altruistic principle prevails. To supply nourishment for the new being, is a drain on the system of the mother; to protect it, her interests, even her life, may be jeopardized; she is fulfilling her last and highest function, and her interests are as noth- ing compared with the interests of the new being ; until it has been rendered self-protecting, her mission will not be complete. What is the meaning of all this? Simply that Nature despises the individual, but loves the race ; and that each new generation represents the farthest advance along that line of unceasing progress, which is a part of Nature’s plan. In the light of these known laws of development, how shall we regard the alleged law of maternal impressions? We have before our mind’s eye an ovum; male and fe- male elements have combined ; a miracle has been per- formed ; a new being has been ushered into the world. It matters not, in our present view, whether this new being lies in an egg-shell or in a uterus ; it is an organic unit, an individual, immutably differentiated from each and every other being that is, or ever has been, or ever shall be in existence. It has come into the world endowed with certain potentialities, the accumulated ten- dencies of hosts of ancestors; it has come to battle with a host of adverse tendencies—the forces of the environ- ment. These adverse powers are fully equipped and ready for battle, while the powers of the new being are as yet but potential. The battle would indeed be a dis- astrous one for the new being were it left to its own de- Vices; but Nature decrees that it shall have aid from the maternal organism. All her instincts, habits, and Capacities are made subservient to this end. All, did I Say ? No, not quite all, if the theory of maternal im- pressions be true; for one capacity then hangs unceas- ingly as a menace over the head of the new being. If this theory be true, the mother, even while she strives 140 NEW YORK STATE MEDICAL ASSOCIATION. to protect and nurture the new being, may mutilate it by an uncontrollable action of her plastic mind. Does this seem consistent with Nature’s great, progressive plan 2 Does it harmonise with the fundamental laws of evolution ? Of course the mother cannot protect the foetus abso- lutely from the forces which play upon her, but her mis- sion is to mollify their influence as far as possible. Can we suppose that while doing this, in obedience to a general law, she is made to constantly menace the foetus through the operation of a subordinate law . If so, what becomes of our belief that each law must be in harmony with every other law throughout the universe ? Suppose the mother to be a deer, and that as she roams the forest, gathering nourishment for the foetus she has been called upon to protect, a panther springs upon her and lacerates her haunches ; but she escapes with her life. Acting in true maternal capacity, she has saved the life of her foetus; but we are asked to believe that the pain and terror which that mother experienced, may make an impress on the new being which will cripple it for life. What conceivable purpose has been served by such a mutilation ? What is this mind which is said to stand with such menacing and domineering power over each new being ? In the modern view, as I understand it, consciousness is held to be itself an incidental condition, important, of course, in the history of each race, but never all-impor- tant. A transitory State of consciousness, then, is a mere incident within an incident ; a fleeting condition of such insignificance that it is not permitted to govern the vital functions of the being which experiences it. Much less, then, can we suppose it to govern the vital functions of another being. If we admit that a mental state may have such power as the theory of maternal impressions Supposes, consider for a moment what a far-reaching capacity is predicated. It is the actual operation of mind within another body; for, we have seen that the MATERNAL IMPRESSIONS. 141 new being is an individual entity, even as it lies in the uterus. But again, why should the Operation of this alleged law be restricted to the child in utero * If the life of the new being, as such, dates from the moment of conception ; if the development of the foetus from that moment is a steady development, in which even the birth is merely an incident, how shall we fix upon a time at which maternal impressions shall cease to operate, if they ever operate at all ? If the human foetus, for example, may be marked by a mental state of the mother when it has lain two weeks or two months in wtero, why may it not be similarly marked at three, six, eight, or ten months, even though in the last instance it is drawing its nourishment from the breast instead of from the uterus : Some of the ablest advocates of the doctrine of maternal impressions, have contended that such impressions can operate only during the first few weeks of human gestation. I maintain that there is no philosophical reason for such limitation, or for any limitation short of the full development of the young organism. When the human child is two years old, it is still as unequivocally dependent upon some other being for its nutrition, as when it lay in the uterus. Its tissues are still developing hourly, and it is probably the source of far greater maternal solicitude, and the object of far greater maternal love than at the earlier period. If the maternal thought or emotion could directly affect it then, I affirm that logical thinking demands of us to believe that the same maternal mental states can similarly affect it now, not perhaps in the same degree, but in the same kind. Bear in mind, I have excluded from present con- sideration, the indirect influence of altered nutrition, of diseased blood, and of uterine anomalies. I speak here Only of direct mental transfer, of what may truly be termed, a maternal impression. If there be a weak link in the chain of reasoning, which demands that the law of maternal impressions, if law it be, shall operate upon the new organism during its entire time of development, 142 NEW YORK STATE MEDICAL ASSOCIATION. I am unable to detect that link. It would thus seem that if this question of maternal impressions were dem- onstrated, it would have a direct bearing on the alluring problems of Theosophy, which so exercise the minds of a certain class of philosophers to-day. In this wider view, to which, as it seems to me, a strict reasoning forces us, the question of a non-nervous umbilical cord, on which much stress is sometimes laid, is seen to be of no significance whatever. Indeed, even in a more restricted view, I cannot see that we would be greatly aided if nerves were found in the cord, and if these were proven to connect with the nerves of the mother. We know nothing of nervous currents oper- ating, for example, with such force as to amputate mem- bers ; and we are quite unable to conceive how the nas- cent nervous system of the foetus could transform the nervous currents of the mother into agents of such effi- ciency. It is quite as easy to imagine the mental state of the mother operating directly on the foetus—or rather, the two things are equally inconceivable. But the inconceivable is not necessarily the impossible. It is not because we cannot understand this alleged law of maternal impressions, that we must reject it ; it is because we cannot make it seem compatible with other and wider laws. Of what effect are the laws of heredity, if, at any moment, a capricious consciousness—an inci- dental condition Operating for a moment in an inconse- Quential Organism—can overthrow its tenets? Natural selection might have wrought its finest structure ; all the forces of countless generations might have combined to produce a faultless being ; but an accidental emotion steps in and pushes aside all these cumulative forces. Chance supplants law in the organic world. Such are the philosophical bearings of the question of maternal impressions, as I see them. But let me hasten to add that I make no pretence to speak with the voice of an Oracle. As I have thought on this topic, an alternative possibility has all the time been MA 7'EIRNAL IMPRESSIONS. 143 before me. Perchance, I have said to myself, all that consciousness about which you talk is not an incident, but the one thing paramount in the organic world; every thought of the mother operates upon the foetus, pushing it, for the most part, onward. The thought is alluring, and argument is not wanting which might seem to sus- tain such a view. Since it might be said, the foetus cannot be absolutely shielded from the forces of the environment, and since the mind of the mother is an exemplification of these forces, may not the maternal consciousness be one of the channels by which the infant organism is made to enter into the struggle for existence, just as nutritional states of the mother are such channels 2 I think we must ad- mit that such may be the case. But if so, biological con- sistency demands that the forces of consciousness shall be modified, not accentuated in their action on the new being. When nutritional vicissitudes play upon the mother, they affect her tissues first, and most markedly; the tissues of the foetus later, and less markedly. Must we not suppose that the same law applies to conscious- ness, if that also be a channel of attack upon the foetus? Yet the alleged cases of maternal impression suppose this consciousness to be malevolently directed against the foetus, with such a force as it never displays in its oper- ation on the maternal organism itself. But, these cases in which consciousness is alleged to act with such disastrous efficiency are rare; may they not be perverted examples of a general law, which ordinarily operates for the good of the foetus? The animal organism is not perfect; it acts always in obedience to law, but its actions may vary within limits, Perverted actions, carried to the extreme of these limits, may give us a glimpse of the operation of a law, which Otherwise we could not recognise, though its operation Were incessant. In this view, it must be supposed, if we admit the operation of maternal impressions in a single Case, that each incidental operation of maternal con- Sciousness operates more or less efficiently upon the 144 NEW YORK STATE MEDICAL ASSOCIATION. foetal organism ; just as we must Suppose that each nu- tritional change of the mother in Some degree affects that foetus. This point of view is doubly alluring, because by its aid we can explain one of the great problems of biology—the cause of the so-called Spontaneous varia- tions on which the Darwinian hypothesis is based. The hunted hare, longing for longer legs to aid her flight, transmits that desire with energising force to the foetus in her uterus; and so on, and on. A pleasing fancy, is it not ? But I fear it is only a fancy. I cannot make it seem consistent with what I know of organic law. Still it shows another of the marvelous implications of this question of maternal impressions. I will not ask you to look further with me into the mazes of uncertainty which encompass this question. Instead, let me repeat, that whatever our theories may seem to prove or disprove, experience must bring the final verdict ; philosophy to-day is only the handmaid of science. I have had no thought of settling definitely in your minds, or in mine, this question of maternal im- pressions, by an appeal to theory. What I have hoped to do, however, is to show how vastly more important is the question, than is commonly supposed. I have touched upon but one of its phases, yet I have succeeded ill, if I have not proven that we have here the key to momentous physiological problems. It remains for us, as physicians, to use that key. I know of no question within the scope of medicine, on the solution of which may hang so many important and far-reaching im- plications. It seems to me, therefore, that it should be the duty of every physician to fully explore the his- tory of every suggestive case of alleged maternal im- pression which comes in his way. A single seemingly demonstrative case, in which the hereditary history, the nutritional possibilities, and the actual facts of the mental state alleged to have acted on the foetus had been put to a rigidly Scientific test, would be not only a unique case in medical annals, but a valuable contribu- MATERNAL IMPRESSIOWS. 145 tion to biological literature, and, incidentally, to specu- lative philosophy. I speak with due deliberation, when I express the opinion, that a truly demonstrative series of cases on this subject, would be the most momentous single contribution to biology and psychology, which has appeared since the dawning of the Darwinian epoch. This, then, must be my apology for addressing you in this theoretical vein. I thought if I could help to arouse a widespread professional interest in this topic, I would do a better service than by the presentation of any case at my command, or by any practical discussion within my knowledge. 10 CLINICAL CONTRIBUTIONS TO THE SUBJECT OF BRAIN SURGERY. By Roswell, PARK, M. D., of Erie County. November 16, 1892. It is my intention in the following paper to report and comment upon certain personal experiences in the rather new field of intra-cranial surgery, illuminated, as it has been, by the light of recent researches, rather than to endeavor to present any new aspects of the subject. After a man has done a certain amount of this kind of work, his experience and deductions become of value to others, and the sole purpose of the present communica- tion is to make it as helpful to others as possible. Nor do I intend to touch upon all possible phases of the sub- ject, but rather upon some of the more common cases of this general character. This is not intended to be a comprehensive or complete personal record ; the in- stances reported are simply those selected from a much larger number, because they appear to me to be of in- terest. Hence the frequent use of the personal pronoun. INTRA-CRANIAL AIBSCESS. As is well known, abscess in the brain must be the re- sult either of direct infection or of embolic disturbance. The latter it is sometimes easy to trace ; explanation of the former is frequently much more difficult. While it is everywhere acknowledged that abscess in the brain may follow external injury to the skull, it is usually difficult to fully appreciate the minute mechanism of its produc- tion, and although a collection of pus may be found directly beneath and two inches below an external scar, we may be absolutely unable to demonstrate the path PRAIN SURGERY. 147 pursued by the agents which have produced it. In the following case, which I shall briefly report, the path of infection is made reasonably clear. The case concerns a lady approaching elderly life, from whose upper nasal passage on one side a nasal polyp was removed by Dr. Hinkel, of Buffalo. At first she did well ; but, later, rather severe nasal symptoms presented themselves, and at the expiration of about four weeks she devel- oped brain symptoms, and became unconscious. In this condition, Dr. Putnam, together with Dr. Hinkel, diagnosticated a probable brain abscess, and, with these two gentlemen, I saw her, and fully concurred in their diagnosis. In this comatose condition there were no localising symptoms whatever, and it was by inference, rather than by any safer guide, that we decided to explore the frontal lobe. Accordingly, without an anaesthetic, I raised a frontal flap, and made a good-sized trephine opening about 2.5 cm. above the orbit, on the side from which the polyp had been removed. After opening the dura, which appeared normal, I used the needle of an exploring syringe, and passed it in in several directions, once quite through the falx and 3 cm. into the other hemisphere, searching for pus. Upon the fourth or fifth attempt it was found directly back of the trephine open- ing, and at a depth of about 3 cm. The abscess cavity was then freely opened, and 12 c.c. of fresh pus were evacuated. The cavity was drained with rubber tubing, and the wound closed and dressed. The patient never recovered consciousness, but died the following day. Examination was fortunately permitted, and it was found that on the other side, in almost the exactly corresponding locality, was a similar col- lection of pus of about the same amount. The point of my needle must have gone within a very short distance of it, although it was completely missed. Here was a case similar to others that have been noted, where the surgeon is deluded into contenting himself with the discovery of one brain abscess, while more or less narrowly missing others in its neighborhood. At the same time, it must be said that there was absolutely nothing about the case to lead to a suspicion of trouble Other than that discovered, which seemed ample for an explanation of the symptoms presented. The case is also of pathological interest, since it gives a clinical demonstration of recently discovered anatomi- Cal facts concerning the lymph-vascular connection between the nasal region and the encephalon. It more- OVer indicates a possible source of danger in operations Within the nasal cavity. 148 NEW YORK STATE MEDICAL ASSOOIATION. HAEMORREIAGE. One of the most complete demonstrations of the forma- tion of clot, and the proper measure for its removal, that I have ever seen, was the following: In February, 1889, a young man in an adjoining town was injured by a falling board, which inflicted a large scalp wound near the left parietal eminence. He was stunned, but quickly recovered consciousness, and was attended by a local physician, who showed himself not keenly alive to modern practice in this regard, and who sewed up the scalp wound with- out any of the precautions at present customary. He was then put on the train, and sent to the Buffalo General Hospital, which he reached in the evening. On his arrival at the station, where he was met by the ambulance, it was noted that he used his right arm, but that during the quarter of an hour spent in the removal to the institution, he lost the use of it. When he entered the hospital he was able to talk, but within half an hour he lost his power of speech, and within an hour was completely aphasic, with right brachial monoplegia. I did not see him until the following morning, when the house-staff had him ready for operation. His condition had not grown worse during the night. Naturally, the diagnosis was that of a clot pres- sing upon certain centres, and the indication for operation was most plain. After anaesthetising him, I found considerable external injury of the soft parts, with apparently local signs of infection. After such cleansing and disinfection as was possible, I found a depressed fracture, about the size of a nickel five-cent piece. The trephine was applied at a point over the arm and speech centre, and a considerable portion of slightly depressed bone was removed, its inner table being considerably splintered. There was no laceration of the dura, which, however, was dark in hue and bulged into the wound. Upon making a small incision, a piece of clot was shot out from the dural wound, and literally projected to a distance of fifteen or eighteen inches, showing the extent of intra-cranial pressure. Enlarging the incision, a considerable quantity of clot, fully two tablespoonfuls, was removed with probe, spoon, and irrigating stream. A number of small brain fragments were also ex- truded, showing that there had been laceration beneath the unbroken dura. His condition was not materially changed by the operation, and three days later the wound was found united without any pus. On the follow- ing day, however, his temperature quickly rose, the flap bulged somewhat, and upon removing some stitches, considerable pus was discharged. It will be sufficient to state, in this case, that the patient manifested no im- provement, but became weaker, and died some three weeks later; and that upon autopsy, three deep abscesses were found, apparently in the path of motor conduction, which would probably account for the fact that no new localising Symptoms developed themselves. JBRAIN SURGERY. 149 This was clearly an instance of primary infection of a head injury, which subsequent endeavors were powerless to avert, and illustrates very forcibly the general state- ment, that the fate of such cases is really in the hands of the man who first attends them. A corollary is, that if the first aid rendered is not based upon aseptic principles, the case is usually thereby placed beyond the pale of surgical help. Another case of haemorrhage of different character and happier termination is the following: A lad of fifteen was, in June of the present year, struck on the right side of his head by a wagon; he was unconscious for a time. There was no distinct scalp wound, only some bruising and ecchymosis. He was at- tended first by Dr. Schladermund, later by Dr. Dorr. With these gentle- men I saw him, six days later. In the meantime, no motor or localising symptoms had developed, but on the previous day his temperature began to rise, and he had become very peevish and restless, although he was up and about the house. I could easily feel a flattened and depressed area back of the right parietal eminence. After shaving the scalp, it was found ecchymotic over and back of the ear. On raising it, the periosteum was found separated from the underlying bone, and an irregular, V-shaped, linear fissure with depression, was found. The trephine was applied 5 cm. away from the ear, on a line from the meatus to the vertex. Immediately upon raising the button of bone, I came upon a very firm extra-dural clot in which organisation had begun, and which, after cutting away a large amount of bone, I found to cover an area 6 by 10 cm. (equal to 60 Sq. cm.), and to be at least 14 cm. thick in its central portion. So tena- cious was it, that it was removed with considerable difficulty. After its removal, the brain did not at once rise to its proper level, and I did not think it necessary to open the dura. The wound was closed without drainage, and rapid and perfect recovery ensued. I have seen many large, flat clots, inside and outside the dura, but never before had thought it possible that a clot of this size and thickness could form, with so little mental, psychical, or motor disturbance. FRACTURES. The following cases of aggravated and fatal fracture Seem to me worthy of mention: The first, was that of a middle-aged man who fell upon a slippery side- Walk, and struck upon the back of the head, although his head did not 150 NEW YORK STATE MEDICAL ASSOCIATION. receive the full violence of the fall. He was unconscious from the time of the injury, and was brought to the hospital. He was operated on in the evening, a few hours after his injury. At this time he was profoundly comatose, in a rather bad condition generally, with a scalp wound upon the right side of the head, and evident depressed fracture. Without an anaesthetic, a large flap was raised, and revealed an astonishing condition of multiple fracture extending in all directions, the fragments being more or less interlocked until disturbed, after which, the more I picked out, the more dislocated did the others become, and it seemed as if the skull were cracked into a number of pieces. After commencing the operation there seemed to be no indication as to just where to stop, except the strength of the patient. The longitudinal sinus had been penetrated by a spicule, and bled viciously on removal of the little fragment. So much blood was lost before this could be effectually closed, that I hastily discontinued further attempts, and bent my energies to getting him off the table alive. He died shortly after the dressings were completed. His skull was thin, the bones seemed rather brittle, but this was the most extensive fracture following a common injury that I have ever met with. A second case of this character was that of a man of forty, who, on the 4th day of April, 1892, fell from a height not exceeding five feet, and was found unconscious. Accounts differ as to whether a stone fell with him, and struck his head, or not, but at all events there were no perceptible bruises on that or any other part of the body. On the morning following the injury he was up and about the house, walking, using his hands, but not talking, only replying by an inarticulate murmur to questions, i. e., with aphonia. The evacuations were attended to naturally. During the third night following the injury, he became hemiplegic on the right side, and the next morning was comatose. I saw him with Drs. Harrington and Niemand, and found the right side absolutely paralysed, and that he pre- sented all the Ordinary signs of compression, save that the pupils responded to light. On careful palpation no tumor could be detected, or any ex- terior evidence of fracture. The conjunctiva of the right eye was suffused, but not that of the left. As a last resort, operation was undertaken to see if the brain pressure could be relieved. A very little chloroform was required. A large 5 cm. trephine was applied over the left motor area, rather low down, and this, in spite of the fact, that now that his head was shaved, we could see a faint linear ecchymosis behind the opposite (right) ear. Even now, before exposing the bone, we could detect no near, certain sign of fracture, although frac- ture at the base was suspected. The skull was of average thickness. After removing the button of bone, the dura appeared a little darker than natural. It was opened, and it was seen that there was some laceration of the brain substance. The most striking feature was the markedly increased intra-cranial pressure. On further exploration, a little clot was removed from beneath the dura, but the pressure increased. I then passed the needle of an exploring syringe in the direction of the lateral ventricle. At a depth of 6 cm. I found fluid blood, and removed 12 or 15 c.c. with the BRAIN SURGERY 151 syringe. I then passed a director down alongside the needle, and evacu- ated more than 30 c.c. of semi-fluid blood. After its removal, the pressure was so reduced that the cortex subsided below the proper level, and he at once began to move his right arm. I then passed a catgut drain into the ventricle, and closed the dura and external wound. He displayed little or no signs of shock, but died four hours later of pulmonary oedema. A hur- ried autopsy was made, and upon removing the calvarium, it was found that there was complete diastasis of the longitudinal suture, extending well down anteriorly and posteriorly, and that the halves of the skull were al- most ready to fall apart. Their level, however, was not altered, and with all the work I did upon the skull during the operation, no such fracture as this was suspected. A line of fracture was also found running down toward the right ear, below the ecchymotic spot above noted. There were several small clots just beneath the dura, scattered over the surfaces of both hemispheres, and upon the right side some plastic exudate. At the base, especially of the right anterior fossa, was considerable thin clot. In the left hemisphere, about an inch beneath Broca's centre, was a firm clot of the size of a grape. Numerous minute haemorrhages bespoke the extensive lacerations inflicted upon the brain. Here, again, Surprise is excited, that so many and such lesions can occur, with so slight immediate signs and results. A few years ago, alluding to trephining for intra- cranial haemorrhage, Hutchinson said, that “the modern annals of Surgery do not contain any cases of haemor- rhages in which life has been saved by trephining for this state of things.” This statement was put on record, although at the time numerous cases were in print, which completely disproved it, and of which its writer seemed to be ignorant. At present, that surgeon must be con- . sidered as reprehensible, who fails to open the skull in every case where indications of early or late haemor- rhage are met with, aside from the localising symptoms Commonly looked for. It is stated that a high temper- ature, coming on suddenly, with slow, stertorous respira- tion, diminishing consciousness, and hemiplegia, after an interval of consciousness, may be regarded as con- clusive evidence of haemorrhage from the middle menin- geal artery. Of the brilliant results which have followed the diagnosis and exploration of such cases, surgical literature is full. The essential advance made, has been 152 MEW YORK STATE MEDICAL ASSOCIATION, in systematising the indications, and popularising the Operative attack. The most progressive surgeons, more- Over, are coming to the conclusion that even in cases of mild haemorrhage, it is best to trephine, in order to avoid the risks of a small clot retained in the cranial cavity. Indeed, Horsley, to whom we owe so much, is on record as claiming that every case of fracture of the skull should be trephined. For my own part, and so far as the danger of the Operation is concerned, I can only say, that so far as I know, among my own cases, in never a single in- stance has the essential danger of a patient been enhanced by trephining or other operative attack; and I desire to ally myself with those who consider that trephining, properly done, adds scarcely any appreciable danger, while it offers a most important prospect of relief, and One which no conscientious surgeon would willingly dis- regard, or deprive his patient of. IBRAIN TUIMOIRS. With intra-cranial solid tumors I have had compara- tively small experience. In one case, referred to me by Dr. Putnam, where we regarded a tumor as certainly present, but were unable to decide positively whether it was cor- tical, or located along the deep paths of conduction, I made an exploratory operation, which proved of no avail, and, in fact, ended fatally within forty-eight hours. In another case, referred to me by the same gentleman, we were both convinced of the presence of a tumor, but regarded it as inaccessible. After watching the patient's suffering for a long time, we decided to operate, purely for the relief of tension, and I trephined her, doing prac- tically nothing but removing a large area of bone, yet with complete relief of her distressing headache, which relief continued up to the time of her death from the nat- ural consequences of the disease. I have seen quite a num- ber of cases of brain tumor with reference to operation, but have, in most of them, declined to operate; while in BRAIN SURGERY 153 those in which I was willing to do my part, the patients have declined the proffered relief. A somewhat perplex- ing case came under my notice not long ago, in the per- son of an elderly woman, who fell down-stairs and struck her head, and who, a few days later, became comatose, and developed a peculiar sighing respiration, with fre- quent hiccough. I was invited by Dr. Diehl to see her with reference to operation, but could see no operative indications. She died the following day, and on autopsy, there was found acute meningitis of ordinary type. On lifting up the lower surface of the brain, in its removal, a peculiar condition of the lower surface of the cerebel- lum was observed, and after its removal, a cluster of cystic growths was found, which were attached a little to One side of the middle line, upon the lower surface of the cerebellum, where they had made depressions into which they seemed to fit. One of these was of the size of a Small grape, two of the size of large peas, and there were several quite small ones. They had a peculiar pearly sheen, were cystic in character, although their Walls were quite thick, and upon minute examination proved to be cholesteatomata. We learned that during the last few months of her life, the patient had developed a frequent, though not constantly staggering gait, and that she at times complained of giddiness and vertigo. FPILEPSY. No discussion of brain surgery nowadays, in which the Surgical treatment of epilepsy has been disregarded, has been noted in recent surgical literature, and for very ob- vious reasons. My own experience in this direction has been, I imagine, like that of most other surgeons—i.e., a Very mixed and contradictory one. I have had some very brilliant results, and, I think, a few positive cures; on the other hand, I have operated without noticing the slightest permanent improvement. In no distinctly epileptic case has any harm been done by the operation, 154 NEW YORK STATE MEDICAL ASSOCIATION. unless there be included in this category, two cases of linear craniotomy to be spoken of later. If I may be permitted to state my present opinion concerning the Surgical treatment of epilepsy, it would be about as follows: That there are certain cases in which prognosis is very favorable; that there are others in which the Operation must be regarded as an absolute experiment, albeit upon scientific principles ; and still others which, although accompanied by focal symptoms or other feat- ures which ordinarily necessitate operation, we must regard as absolutely hopeless ; and that it is seldom possible to designate to which class a case belongs until the Operation is tried. But I think this statement ought to be tempered by another, to the effect that surgery alone, is rarely, if ever, sufficient, and that it must be accompanied and followed, and, perhaps, even preceded, by medicinal and dietetic treatment ; and that this feat- ure of these cases is too often disregarded. To this second statement should be added, perhaps, a third, to the effect, that when operating for pronounced epilepsy, we have to combat not only a somatic lesion, but an epileptic habit, so to speak, and that a mere removal of the lesion is not necessarily, nor always, enough to break up the well-formed habit ; that it is this which calls for the long-continued post-operative treatment which often causes discouragement and carelessness, and, finally, in- attention and absolute disappointment. I firmly believe that if those who operate frequently for epilepsy, would steadily follow their operations with the other measures above alluded to, and keep them up for five years, at the expiration of that time, much better results would be reported. This refers not only to cases of head injury, where the conventional Operations about the skull are performed, but also to peripheral irritations in other parts of the body, necessitating various other operations. Of purely head or brain cases of this character, I will only call attention to two or three. One was a case oper- ated. On in 1884: BRAIN SURGERY 155 A man, twenty-three years of age, who, when a boy, fell into the water and struck upon a submerged timber. He was unconscious for two days afterward, later on developed epilepsy, and was afterward in the hospital on Ward's Island. He escaped from there when they proposed operation to him, and was eventually picked up in a fit on a Buffalo street, and sent to our hospital. Upon admission, he was having at least one fit every day; there was a distinct depression on one side of the median line ; and the overlying skin was very sensitive. The operation was on December 6, 1884; the bone was very thick (2 cm.), with external depression, but none of the internal table could be made out ; the external sensitive area was excised. For some days he was violently disturbed, then showed ma- terial improvement, and during the last ten days of December, he had no fit, save that upon the last day of the year, he had several. Respiration became so embarrassed as to call for artificial aid. A few days later he was sent to the almshouse, where he had a number of seizures, during one of which a pail of cold water was thrown over him. He quickly recovered, and had no more while there. He left the institution in May, was reported as not having had any fits in three months, but since has not been heard from. The first case attempted in this country in accordance with principles of cerebral localisation, was a patient upon whom I operated November 16, 1886 : * The patient was a man of forty-seven, who more than a year previously had been thrown and dragged upon the ground. Four hours later he be- came unconscious, although there was no external violence to the skull, and remained so for sixty-eight hours, when he gradually recovered. He developed nearly absolute aphasia, his vocabulary being limited to perhaps half a dozen words. His right arm was also paralysed and cold. His epileptic condition developed four months after his injury, and became Very pronounced. His lesion was diagnosticated as cystic degeneration of a clot, and its position correctly determined. Upon trephining it was found, as expected, only perhaps larger. A cyst was discovered with a capacity of 40 c.c. of fluid, and measuring 10 by 3 cm. It was dissected Out, and the patient made a perfect recovery from the operation. His epileptic and aphasic condition, however, have since then only in small measure improved. This latter condition I can explain by atrophy of the third parietal convolution, due to pressure of the cyst. For the former, I can give no more Satisfactory explanation than in any such case. Three or four similar cases where cysts have been ac- curately diagnosticated and indicated either by localising Symptoms, or by external scars, have been operated upon * Wide Trans. Cong. Am. Phys. and Surg., vol. i.; paper by the writer. 156 NEW YORK STATE MEDICAL ASSOCIATION. after much the same fashion, with results, in every case encouraging, but in no case, completely satisfying. It has seemed that in every case the cyst had existed long enough to produce atrophy of the underlying portion of the hemisphere, with permanent loss or disturbance of its proper functions. In one case operated upon last year, I had an expe- rience with haemorrhage which may be of interest and encouragement to others. It was one of those instances of traumatic, Jacksonian epilepsy, with a scar near the middle line of the scalp. The operation was without incident until the dura was opened, and adhesions found between it and the cortex. These were tough and firm, and in the endeavor to remove the adherent portion of the cortex, Some unusually large veins or abnormal con- nections with the longitudinal sinus, were severed, and the bleeding became serious and even alarming. I finally succeeded, to my perfect satisfaction, however, in check- ing it, by packing with iodoform gauze, the tampon of which I retained in situ by the pressure of the overlying skin flap, which was restored to its place after inserting Secondary sutures of silk, which were left long, and tied by a bow-knot. Two days later I untied the knots, lifted up the flap, removed the tampon without a particle of haemorrhage, restored the flap to place, utilised the Secondary sutures for its retention, and got beautiful union by first intention. This patient went home very much improved, but during the hot weather of the past. Summer was, they write me, injudicious, and had some return of his old trouble, the seizures never being of SO Serious a character as before, and being quite controll- able So long as he takes bromides and borax in ordinary doses–a line of treatment which I have urged him to continue indefinitely. * Last Spring, at the meeting of the Surgical Association in Boston, Dr. Beach, of that city, presented to the Asso- ciation a case operated upon for traumatic epilepsy, where, in order to prevent the re-formation of adhesions BRAIN SURGERY 157 between the dura and the other tissues, he had inserted a piece of thin gold foil, carefully sterilised, with appar- ently the best results. Following his example, I have twice operated in the same way, cutting out with a pattern, a piece of dentist’s foil a little larger than the bone opening, and fitting it in, after closing the dura, between it and the margin of the bony defect, then closing the Scalp wound over it, all without drainage. There has not been the slightest disturbance of any Kind, and the progress of these cases, so far as I have been able to judge of them, or to hear, has been very encouraging. This measure (insertion of gold foil) I now intend to introduce and recommend in recent accident cases, where trephining is practiced for depressed fractures, etc., for the purpose of preventing adhesions between the scalp and dura. In another case, a young lady with Jacksonian epi- lepsy, where the aura usually commenced in the arm, and where there were noticed also what my colleague, Dr. Putnam, has been recently the first to call attention to, viz.:-sleep-movements in the same arm—I last spring exposed the arm centre, determined its exact location with the faradic coil, and excised the same, as ac- curately as I could, to the depth of 1 cm. Perfect primary union took place, but the result has been dis- appointing, there having been only slight amelioration Of symptoms. In her case, however, we have had to Contend with peculiar gastric symptoms, dilatation of the stomach, etc., which seem to have had a marked in- fluence in depriving her of the benefits to have been legitimately expected from such an operation. More- Over, she has a peculiar idiosyncrasy, in that she cannot take bromides in any form without intense bromism; her body showing many scars of ulcers produced in the attempt to bring her under the influence of the drug. 158 NEW YORK STATE MEDICAL ASSOCIATION. PSYCHOPATHIC EQUIVALENT OF EPILEPSY ; DEMENTIA IEPILEPTIC A. Under this head, recent writers have included cases, not of distinct epileptic type, but of paroxysmal, emo- tional, and epileptiform character, the attacks coming on sometimes with, and sometimes without aura or other premonitory symptoms. I have operated upon three well-marked cases of this character within the past few months. The first, was a man, thirty-one years of age, who, on July 20, 1891, was kicked in the left side of the head by a horse, and who some time later was found unconscious. He was carried into the house, and was aroused. He had never had any paralysis. Three days later he began to act strangely, and soon became willful and almost violent. He developed erotic tendencies, and grew rapidly worse so that he could not be kept at home. On July 28th, he was sent to me by Dr. Krehbiel, of Yorkshire Centre. At this time the patient was difficult to control and mildly mani- acal. On July 29th, I found a depressed area on the left side, near the parietal eminence, a little anterior to it, yet he had absolutely no motor symptoms. At this point there was an H-shaped scar. Immediate opera- tion was done under chloroform. Beneath the Scalp I found a depression about the size of a half-dollar, around which Ichiselled so as to entirely lift and remove the depressed portion. The bone was well comminuted; there was a small clot beneath the bone, but none beneath the dura. The bone was not replaced, and the wound was closed without drainage. He made a rapid recovery ; returned home in one week with his mind nearly clear, and with his disposition as it had been before his injury. My second case was a man of forty-five, who, when a young man, had had an extensive compound fracture of the skull, and who for a while was under the observation of the late Dr. Gray, of Utica, who advised against operation in accordance with the practice of that day. Of late years the man has developed distinct epileptiform seizures, followed by violent ma- niacal attacks, during which he was positively dangerous, so that his fam- ily lived in constant fear; moreover, his disposition and temper seemed to be gradually changing under this stress, and it got to be a question whether he should submit to an operation or be sent to an asylum. He was placed in my hands by Dr. Putnam for operation. This was performed during October, 1891, the depressed bone being removed, adhesions separated, and a portion of the scar exsected. The change in this case for the better has been most marked, and most gratifying. While it is too much to say that he has not had a single seizure since the operation, they have been reduced to very mild and very rare attacks, and I believe it is now some months since he has had anything which could be called a fit. In temper and dispo- sition he is also quite his old self again. PRAIN SURGERY 159 A third case is one very recently operated on, so that I cannot report final results. The patient was a man of about thirty, who, when five years of age, sustained a bad compound fracture of the left side of the skull. He was so profoundly unconscious, that for two or three days abso- lutely nothing was done for him by the physician in his community. He got married some twelve years ago, and since his marriage has had nearly weekly attacks of faintness, but never any of a convulsive character. These have been followed by sullenness, and by manifestations of quick temper, which have greatly alarmed his family. Inasmuch as there was about the head, at the site of the old injury, a dense, and depressed Scar, I as- cribed his nervous symptoms to the remote effects of the injury, rather than to those of his marriage. In his case, I completely dissected out the scar, trephined and removed a small circular depression of bone, in- serted a piece of gold foil, slipping its edges beneath those of the bone, and closed the wound as usual without drainage. Up to the moment of pub- lication, this case has steadily improved. LINEAR CRANIOTOMY, OR CRANIECTOMY. My experience with this new and radical procedure has been sufficiently varied and interesting, not to say important, to justify a report of each case. I will give them in the order of their occurrence. CASE I.—J. W., three and one-half years of age, was referred to me by Dr. Crego. As a baby, he was restless and “jerky,” and when nine months old had convulsions of the entire body. As he grew older he would sometimes fall in some of them. These slowly assumed the con- ventional epileptic type, and by the time he was three years old, or in March, 1891, were perfect examples of grand mal. They also increased in frequency and severity. At that time he began staggering in his gait, and his left leg grew weak. Soon after, the leg showed relative decrease in length and size. His temper became violent and uncontrollable, his epi- leptic seizures more and more frequent, and durin g the twenty-four hours previous to the operation, he had between thirty and forty distinct and severe seizures. Though he was by no means an imbecile, his mental de- velopment was retarded. His skull seemed relatively small for his age, On June 21, 1891, I operated at the General Hospital. A long incision, One inch to the right, and parallel with the middle line, was made from the forehead to the occiput. With cutting bone forceps I excised a strip of bone 2 cm. wide, from the line of growth of the hair in front, nearly to the occipital protuberance behind ; then, detaching the scalp for the pur- pose, I excised a narrow strip of bone over the fissure of Rolando on the right side, down nearly to the temporal fossa. The wounds were closed Without drainage. During the ensuing twenty-four hours, shock was SeVere, and he had several violent epileptic seizures, but he has had none 160 NEW YORK STATE MEDICAL ASSOCIATION. since this first day. His irascibility has subsided, his general health and intelligence have improved, and he now runs, plays, acts, and talks just like other children of his age. CASE II.—Minnie R., four years of age, was referred to me by Dr. Put- nam. This was a case of congenital microcephalus and imbecility. The parents were healthy, and the family history was good, the previous chil- dren being sound. This girl had scarcely ever spoken a word, and mani- fested no more intelligence than an infant of three months. Her fontanelles had closed very early. She led a vegetable sort of existence—without dis- turbance of function. Operation here seemed much less hopeful than in the previous case ; it was, nevertheless, undertaken, July 13, 1891. An incision was made 3 cm. to the left of the middle line, from a point 4 cm. above the left superciliary region, to the occipital protuberance. A strip of bone was excised much nearer to the middle line, After removing it, the scalp was pressed away on the left side, and a strip excised over the Rolandic fissure. I then made a distinct incision over the right Ro- landic fissure, and excised another strip of greater length, the three lines of defect having a common meeting-place. The central grooves were cut with forceps, the lateral grooves with chisel. There was no great haemorrhage, and the wounds were closed without any provision for drain- age. The child nearly collapsed after the operation, and for two days required constant attention. The after-results in this case have been prac- tically nil. There has seemed to be a perceptible improvement in intel- ligence, and the child has appeared a little more alive to what is going on about her, but this is about all that can be said. CASE III.-W. K., eighteen years of age, was referred to me by Dr. Crego. From an early age the patient's mental development has been very disappointing. He is physically large and well developed, but mentally shows scarcely more intelligence than a child of two or three years. At the age of about five, he first showed epileptic manifestations. His seiz- ures were then few and far between. They gradually increased in fre- quency, until now he has several in one day, and rarely goes a few days without any. His temper is usually good, but at times he is excessively willful. The upper portion of his cranium is relatively small, though not conspicuously so ; the muscles of his right side are somewhat atrophied ; and it seems that his epileptic fits have been somewhat more violent on the right side than on the left. His personal habits are good, as is also his family history. Dr. Crego and myself both thought that an extensive cranial opening might give relief, and the experiment was proposed and ac- cepted by the father. The operation was done October 20, 1891. A long incision was made to left of the middle line. When I endeavored to make a longitudinal division of the skull, commencing with a common amputating saw, I found that the bone was very thick. I then applied a trephine over the motor area, and, through the opening thus made, with chisel and gouge-forceps removed a portion of bone, some 5 cm. in diameter, and in shape like a spherical triangle. Through a small opening in the dura I BRAIN SURGERY. 161 found there were no adhesions, but that the arachnoid and pia were suc- culent and oedematous. I started to make a longitudinal excision of bone, but finding the same to be 1 cm. thick, desisted from this attempt, and tried to make simply a large relief opening. The wound was closed with catgut, and an ice-bag applied outside the dressing. At 6 P. M. he was somewhat restless, and had a fit. This condition became more marked, and by midnight, in spite of considerable morphine and other sedatives, he was convulsively restless and violent, and required both a strait-jacket and chloroform. At 4 A. M. he died of exhaustion. CASE IV.-J. M., fifteen years of age. All the children of this family were rachitic. The patient was healthy until he was three years old ; then his nurse used to frighten him, and he grew to be very nervous and timid. He soon began having fits every night, and this continued until he was thirteen years old, when they occurred in the daytime also, and he soon had as many as thirty to forty fits every day. During one of these, he fell and broke his elbow, which is now partially anchylosed. He also cut his fore- head to the bone. For the last two years, he has been lying most of the time helpless in bed, and has had to be fed. His symptoms, mental and convulsive, seemed to occur in cycles of about three weeks each. During the first week of the three, he would be noisy, the second, he would be weeping and wailing, and during the third, apathetic and almost uncon- scious. He rarely spoke. On November 2, 1891, he was brought to my clinic in this third stage, and it seemed impossible to arouse him. He took mechanically most of what was put into his mouth; his bed was con- stantly soiled ; his arms were nearly always in the athetoid condition, and Sometimes his legs were similarly affected, and any little disturbance would bring on a mild seizure, during which his arms were drawn up over his head. There were no scars over his motor areas. On November 7, 1891, the operation was performed in the clinic. A long incision was made to the left of the middle line, and after a first opening with the trephine, along Strip of bone, 1 cm. wide and 13 cm. long, was removed, just to the left of the longitudinal sinus. The operation had to be discontinued because of collapse. The patient stopped breathing, nearly died on the table, and Was revived with great difficulty. The wound was closed as rapidly as possible. He seemed better the same evening, but next day the athetosis Continued ; he became uneasy, and died of shock, twenty-six hours after Operation. CASE W.—S. P., nine years of age. This patient was of Russian-Jewish parentage, his father being an educated man, and the other children healthy. He presented a defective skull development, especially over the left frontal lobe; was imbecile and epileptic; had seizures coming on about every five days. His forehead sloped backward so as to give him some- What the appearance of one of the Aztec children. Mentally he was an im- becile, muttering half a dozen words, and staggering about the room, but in disposition good-natured and even confiding. He was operated upon Novem- ber 14, 1891, in my clinic. In this instance I varied the Ordinary procedure, 11 162 NEW YORK STATE MEDICAL ASSOCIATION. in that I laid up a W-shaped frontal flap, its apex reaching nearly to the vertex of the skull, its extremities extending nearly to the external angular processes. Then a small trephine was applied on each side of the middle line; the opening thus made was connected across the longitudinal sinus, and then two strips of bone excised in a direction parallel to the Scalp in- cisions, by which considerable “spring” was given to the frontal bone, and the fragments of others attached to it. The operation proceeded without incident, and the first dressing was not made until eight days later, when perfect union was found. The immediate effects in this case were not very pronounced; his seizures, however, became less frequent and less severe, and when he left the hospital a few weeks later, he had lost his stag- gering gait, and his various actions and attempted speech showed much more fixedness of purpose than was previously the case. But the results at the end of a year, in his case, have astounded me. He has had no fit for three months, and within a week or two was exhibited again at my clinic. He came up to me, and publicly asked in clear and distinct tones, whether he could go to school. I held some conversation with him before my class, in order to show that he was capable of rational thought, and rational, and even accurate conversation. In addition to this he has de- veloped physically, and his face now has a really intelligent expression, whereas a year ago it was expressionless. CASE WI.—C. S., twelve years of age, of Warren, Pa., was sent to me by Dr. Baker. This child was also an imbecile, speaking but few words, being at times irascible, and having frequent epileptic seizures. There was partial paresis of the left arm, although she used it more or less. In her case there was great asymmetry, there being a decided depression over the right side. She was operated on the same day as the previous case, at a special clinic given for these two cases, and a strip of bone about 1 cm. wide was excised to the right of the middle line, extending well backward, and forward into the frontal bone. The dura was not opened. At the first dressing, one week later, perfect union of the wound was found, and a light dressing only was applied. A few hours later she got restless, and tore this off, and then picked the wound open so that it gaped for its whole distance. It was immediately re-dressed, after disinfection with hydro- peroxygen, but healed the second time by the slower process of granula- tion. During the few weeks of her stay in the hospital, she improved a little. A letter from Dr. Baker, dated October 25, 1892, nearly a year later, states that “she is no better now than she was before operation. For the first three months after operation, there was a marked lessening in the number of paroxysms, but for the last three months the convulsions have been both severe and frequent, she having several daily. She is in much the same condition mentally that she was before operation.” From the foregoing reports it will be seen that I have had six cases of this general character, two of which were promptly fatal, two of which have been practically BRAIN SURGERY. t 163 unaltered, and two of which have been brilliantly suc- cessful beyond all expectation. Of the two fatal cases I can only say, that they belong to a class of patients about whom in general we feel that death is vastly pref- erable to such a life, and while I think the second case might have been benefited had he survived the shock, I regard the first as essentially and absolutely hopeless in every respect. Save in a purely personal sense, I have no regret for the operation, which was freely assented to by the parents. In fact, in every one of these cases, the parents have been made fully aware of the difficulties and dangers, and have in every instance said that they would rather lose their children, than see them live in the condition in which they were at the time of the operation. The two cases where no result has been noted, I sup- pose, must be regarded as belonging to the class of cere- bral atrophies which have been stigmatised by Dr. Starr, as essentially hopeless. In both these cases, the princi- pal regret of the parents is that their children survived the operative ordeal. Of the two successful cases, any man might well feel proud, as having contributed to such marvellous changes. They are of themselves sufficient reward and justification for a score of unsuccessful cases, and lend an element of hope in similar instances, of which the profession should not be deprived. CASE VII.-Since writing the above, I have operated upon an infant of fourteen months, who was born during a natural labor, of a healthy mother, who had borne other healthy children. My little patient showed no ordinary signs of rickets, but her fontanelles closed very early, and she showed scarcely any more sign of intelligence than a vegetable. She Seemed to recognise the difference between light and darkness, to have the Sense of hearing reasonably acute, and to be in good physical condition. Her principal evidence of life and activity, was her constant crying at night. In this instance the father said to me, with tears in his eyes: “Do all you can, and be sure to do what you think is enough, without stinting opera- tion ; for I would rather bring the child away from the hospital in a coffin, than in this condition.” The operation was done in the same way as in Case V., but the child, who stood the operation well, collapsed, and died suddenly the same evening. 164 NEW YORK STATE MEDICAL ASSOCIATION. Without prolonging this paper to too great an extent, I desire, before closing, to invite your attention to a few conclusions, the results of my deliberate convictions and reflections upon this kind of work. 1st. We have not yet learned the possible limits of brain surgery, so called, nor the possible limits to which we may with reasonable safety interfere with the func- tions of the brain or its component parts. Final knowl- edge in this respect will come, probably, rather through clinical experience, than through experimental inves- tigation. 2d. I have had a number of brain cases whose history shows that at the time of reception of the injury, the symptoms were so serious and severe as to lead the medi- cal attendants to consider the case hopeless, so that prac- tically nothing was done. I wish to say all I can to con- demn this apathetic course, and to urge that the most desperate case be attended to at once, with the same at- tention to detail, as though it were quite hopeful in its outlook. 3d. In many of my own cases, and my experience is like that of many others, the mental or other disturbance that has finally led to operation, has been allowed to run along, often for years and years, and patients have been brought to the surgeon only as a last resort. This course is as unwise in these cases, as when we deal with malignant disease, and the profession generally should learn that prognosis would be very much more favorable in Such cases, were they operated upon when these dis- turbances first make their appearance. 4th. Personal experience has convinced me that when I have erred in operating for epilepsy or psychic dis- turbance, it has been rather on the side of doing too little than too much. For instance, in one of the cases alluded to under the caption “Epilepsy,” in which no improvement was manifested, I am now sorry that I did not take out so much of the arm centre as to produce, at least, temporary paralysis of the arm. In other words, DISCUSSION. 165 I have never regretted doing too much, but in several cases, have regretted not doing more than was done. 5th. I wish again to insist upon the necessity of long- continued medicinal and dietetic treatment after these cases have passed out of the hands of the surgeon. DISCUSSION. DR. JAMEs W. PUTNAM, of Erie county, said that the paper contained many cases which he had himself had the opportunity of seeing and study- ing, and consequently it was to him especially interesting. He concurred fully with the conclusions of the author. Operations for epilepsy, al- though not holding out much encouragement, should not be discontinued, for improvement has often been seen one or two years after the operation, if vigorous medicinal treatment had been kept up. In the case operated upon by Dr. Park, one year ago, the patient had frequent and severe attacks, and was vigorously treated with the bromides before operation, but with- out benefit. At the operation, a piece of depressed bone was removed, and after a vigorous use of the bromides, the attacks became very much less frequent, so that now, the interval between the attacks is about thirteen months. Some of these cases have proved more amenable to treatment with the bromides after operation, than before. One of the cases referred to in the paper, was operated upon because the patient suffered from very severe headaches, which were looked upon as one of the symptoms of what was considered to be a cerebral growth. The symptoms, however, were not sufficiently severe in themselves to make it seem advisable to operate for the removal of the tumor. The operation was done with a view to relieving the pressure, and this was accomplished by the removal of a considerable portion of bone. The patient no longer suffers from the severe paroxysms of pain. We should, therefore, bear in mind the value of trephining in cases of brain tumor, even though we have no idea of re- moving the tumor. Regarding the first case reported in the paper, he dif- fered a little with the author, in saying there were no localisation symptoms; for, although there were no positive ones, there were negative ones—cer- tain psychical disturbances, so that she would forget what was said to her, and her vocabulary became reduced to a very few words. There were also disturbances of mentality, pointing, though not positively, to trouble in the frontal lobe. DR. F. W. Ross, of Chemung county, said that he only desired to em- phasise the remarks made by the author, regarding cases which seemed to be almost hopeless. He recalled two cases of traumatism in the frontal region, in which it was decided that an operation was almost useless; yet at the operation, a large clot was removed from the brain, and the patients recovered with only loss of the function of one eye. Within the past week, a man who had received a very severe crushing injury in the frontal region, Was Sent to the hospital, twelve hours after the accident. He had been at- tended during this interval by a surgeon from outside. On admission, his 166 NEW YORK STATE MEDICAL ASSOCIATION. pulse was almost imperceptible, and he was unconscious, but his respira. tions were fairly regular. The speaker re-opened the original wound, and found it full of dirt ; there was a depression of the parietal bone. Tre- phining was performed, the depressed bone elevated, and the blood clots cleared out. This man died, and the speaker felt that the untoward result was largely due to the negligence of the first surgeon ; for, in all cases of injury to the brain, we should operate promptly, and as carefully as though we fully expected the patient to recover. THE PRESIDENT said that when we considered the few recoveries which took place, as compared with the numerous operations which have been performed for epilepsy, we must certainly admit that the results are not very brilliant, but they are still sufficiently encouraging to warrant con- tinued efforts in this direction, in the hope that the experience so gained may lead to still better results. As had been said, the great obstacle to success is the habit of epilepsy, unless that habit is directly produced by the pres- sure of spiculae of bone, or something of that character. He thought, also, that many of the cases which had been claimed as successes, had been re- ported too soon after operation, and that results which, at first, seemed to be most brilliant, would ultimately prove to be far different. The only conclusion to be drawn, however, is the one given in the paper, viz.:--the necessity of continuing the bromide treatment, with especial attention to dietetics; for, as a rule, physicians are careless as to this matter of diet, and the physician himself is often responsible for the continuance, or the severity of the fits. He recalled the case of a yonng man who had the status epilepticus, and had such continued fits that his friends were called in to see him die. After coming out of this status epilepticus, the speaker had inquired into his diet, and had learned that he was inclined to eat everything that was on the table, and to eat excessively. After restricting him to a milk diet, there was no return of the 8tatus epilepticus, and even the epileptic fits decreased markedly in number, and his whole general condition improved. The treatment with the bromides was of course con- tinued, and he is now in a far different condition from that previous to the restriction of his diet. DR. JoHN CRONYN, of Erie county, said that the remarks of the pre- ceding speaker on the subject of prematurely reporting these cases, had recalled to his mind the first case which he believed had been operated upon for traumatic epilepsy. In 1846, the then professor of physiology and anatomy at the University in Toronto, performed an operation on a young man who was an epileptic maniac in the asylum. A cicatrix was found pressing upon the cortex, and was removed. For seven and a half years afterwards, he remained perfectly well, and was intelligent. At the end of this time, he was returned to the asylum as bad as before the opera- tion. This goes to prove that immediate improvement is not to be relied upon as a proof of the permanency of the cure. This subject is still 8wö judice, but the operation should not be abandoned until the matter is definitely settled. A PLEA FOR THE EARLY EXTIRPATION OF TUMORS. By John W. S. Gouley, M. D., of New York County. Movember 16, 1892. At what period of the development of a tumor is its extirpation justifiable . The answers to this question for a long time have been divided between early and late sur- gical intervention and non-intervention. Some surgeons, at home and abroad, have favored and do now favor early extirpation even in the case of benign tumors, but many advise non-interference so long as tumors are small, painless, stationary, or of slow growth. The observations of experienced clinicians indicate that malignant tumors sometimes have a long period of latency, and that they often begin as benign tumors, which are stationary for years or grow very slowly, and then increase with the greatest rapidity. Such seems to be the progress of some of the mammary tumors, notably certain adenomata, which occasionally lead astray the medical adviser respecting prognosis; for, the diagnosis having been made and the tumor growing slowly, its removal is condemned, or deferred until perhaps the disease has already become malignant. The recent ad- Vances in pathology and in surgical procedures, are very likely to induce the majority of surgeons to modify their views in relation to the indication for operative inter- Vention. - If it were generally known among intelligent people that many innocent tumors sooner or later become malig- nant, and that malignant tumors often simulate benign tumors, and remain quiescent for a great while, the suf- ferers would unhesitatingly consent to the removal of 168 NEW YORK STATE MEDICAL ASSOCIATION. these morbid growths in their inception, long before the possible advent of serious mischiefs, or when the cure might be effected by minor operations which would leave the smallest scars, especially in such parts as the face, neck, arms, or hands. - In the discussion of the initial question, the following points will be considered: (1) The relative frequency of malignant and benign tumors; (2) The liability of the transformation of benign into malignant tumors; (3) The impropriety of delaying operative interference ; and (4) The advantages of early operations. 1. The testimony of careful observers tends to show that the malignant exceed the benign tumors in frequency, and also that many malignant tumors remain stationary and seemingly harmless for one, two, six, eight years, or even for longer periods, then increase rapidly, and soon contaminate the system. Several modern writers have analysed tumors on a sufficiently large Scale to give some notion of the relative frequency of malignant and benign tumors. Mr. W. R. Williams's analysis of 11,100 cases of tumors shows fifty-three per cent. to be can- cerous, and of these, twenty-four per cent. to be cancers of the breast. Dr. S. W. Gross cited 649 cases of mam- mary tumors. Of these 649 tumors, 587 were malignant and only 62 were benign. Of the 587 malignant tumors, 530 were carcinomata and 57 were sarcomata. Of the 62 benign tumors, 48 were inomata, 2 were adenomata, and 12 were cystomata. This excess of malignant over benign tumors noted by Dr. Gross corresponds with the observations of nearly all pathologists; but the propor- tion of adenomata stated by him is very small as com- pared with the experiences of other observers, although he afterward spoke of 5 adenomata examined by himself and of 13 examples which he had collated, making 18 additional cases. Among Mr. Williams's 11,100 tumors are 280 cases of breast adenoma to 68 cases of breast Sar- coma, and 1,439 cases of breast carcinoma—in all, 1,781 cases, with about sixteen per cent. of adenomata ; while EARLY EXTIRPATION OF TUMQRS. 169 among Dr. Gross's cases there are 587 malignant tumors and 20 adenomata, making in all 607, with only about three per cent. of adenomata. - Sir Astley Cooper, who first described adenomata of the breast under the name of “chronic mammary tu- mors,” regarded this disease as common, and reported a series of illustrative cases in his work on the breast. These were cases of circumscribed adenomata. “upon, rather than in the breast,” the diffuse adenomata being those which are viewed as so rare by Broca and other writers. Is it not possible that this great rarity of dif- fuse adenomata may be more apparant than real, and that many of the excised carcinomata may at one time have been diffuse adenomata ? This question can be definitely settled only when great numbers of breasts shall be excised much earlier than heretofore, or as soon as the first traces of disease can be discerned. If, then, it should be shown that diffuse adenomata are very frequent instead of being very rare, it would be fair to infer that most of the tumors formerly excised as carci- nomata had probably begun as diffuse adenomata, and that something like prophylaxis of carcinomata might be effected by the early excision of diffuse adenomata. In such cases the entire breast would necessarily be re- moved, while in circumscribed adenomata the breast would be saved. Respecting the age of individuals affected with adeno- mata as compared with that of cancerous subjects, Broca has compiled a very interesting table of cases reported by Lebert, Velpeau, Bauchet, and Rouyer. This table Comprises 152 cases of tumors. Of these 152 cases, 62 Were cancers of the breast ; 90 were adenomata, and of the 90 adenomata, 70 were of the mammary, 11 of the parotid, and 9 of the palatine glands. Before the age of twenty there were 6 cases of mammary adenoma, 8 cases of parotid adenoma, 3 cases of palatine adenoma, and no case of mammary cancer. From the age of twenty to twenty-five there were 17 cases of mammary 170 NEW YORK STATE MEDICAL ASSOCIATION. adenoma, 1 of parotid, and 1 of palatine adenoma, and no case of mammary cancer. From the age of twenty-six to thirty there were 9 cases of mammary adenoma, 1 of parotid and 1 of palatine adenoma, and 1 case of mammary cancer. From the age of thirty-one to forty there were 20 cases of mammary adenoma, 5 cases Of parotid adenoma, 3 cases of palatine adenoma, and 12 cases of mammary cancer. From the age of forty-one to fifty there were 15 cases of mammary adenoma, 1 case of parotid and 1 case of palatine adenoma, and 21 cases of mammary cancer. From the age of fifty-one to fifty- five there were 3 cases of mammary adenoma, none of parotid or of palatine adenoma, and 12 cases of mam- mary cancer. Beyond the age of fity-five there were no cases of mammary, parotid, or palatine adenoma, but there were 16 cases of mammary cancer. Among the interesting features of this table are the following: There are in it no cases of cancer up to the age of twenty-five, 1 case between twenty-six and thirty, and 12 cases between thirty-one and forty, so that up to the age of forty there are only 13 cases of breast cancer to 52 cases of breast adenoma, while from the age of forty-one to fifty-five and upward, the high figures are reversed, and there are 49 cases of breast cancer to 18 cases of breast adenoma. This is in corroboration of the statement of Sir Astley Cooper, and of other observers, that circumscribed adenoma of the breast occurs with greatest frequency in early life—i. e., between the ages of fifteen and thirty, while carcinoma is rarely devel- oped before the age of forty. Mr. Thomas Bryant, in his work on the diseases of the breast, gives the following analysis of one hundred cases of mammary “adenofibroma'' observed by him, illus- trating the ages at which they occur: “Twenty-seven cases were first discovered between puberty and the age of twenty—i. e., during the devel- opmental stage of the breast's life. “Thirty-five cases appeared between twenty-one and FARLY EXTIRPATION OF TUMC) RS. 171 thirty years of age, or during the period of functional perfection. “Twenty-two cases appeared between thirty-one and forty, during the period of its maturity. “Thirteen cases appeared during forty-one and fifty, and 3 cases appeared in women over fifty, or during the period of its functional decline. “Forty-six of these cases occurred in single women, 39 in the married and prolific, 15 in the married and sterile.” The question of the influence of sex upon tumor for- mation need not be discussed, as it is unnecessary to the purposes of this plea, but it may be of incidental interest to state the conclusion arrived at by statisticians, which is that of all cancers, sixty and even seventy per cent. occur in females. Another item worthy of note is the rate of mortality from malignant tumors as compared with other diseases. In the discussion on tumors held during the fifth annual meeting of the New York State Medical Association, Dr. Alfred L. Carroll, formerly secretary of the New York State Board of Health, answered the question, “What is the rate of mortality from malignant neoplasmata as compared with other diseases 3 '' and based his answer upon an examination of the mortuary statistics of the State of New York for the years 1885, 1886, and 1887, and said: “In these three years the deaths from all causes certified in the State at large amounted to 264,161. Of these, 6,262 were reported as due to ‘cancer’—1 in every 42.2, or a little more than two and a third per cent.” Dr. Carroll’s computation gives a percentage of mortality from cancer only a little lower than that of the late Dr. William Farr, which was based upon the anal- ysis of millions of deaths from all causes. Aside from the consideration of the relative frequency of malignant and benign tumors, their discrimination, clinically, is often so difficult that surgeons are justified in advising immediate extirpation, and in relying upon 172 NEW YORK STATE MEDICAL ASSOCIATION. the microscope to insure the diagnosis and establish the prognosis. 2. The liability to the transformation of benign into malignant tumors has long been recognised, but the his- tological demonstration of the phenomenon is modern. It has happened that some tumors have been excised during their transition from the benign to the malignant type, and that this metamorphic process has been verified by microscopical examination of different parts of the growths. But so far it has not been possible to deter- mine the precise time of the beginning of the transfor- mation. The clinical evidence that tumors, retaining the char- acters of benignity for a number of years, often suddenly acquire those of malignity, does not appear to have been questioned, and many surgeons, such as Broca, Werneuil, Richet, Labbé, Klebs, Billroth, Sir James Paget, Mr. Bryant, Dr. Gross, and others, have made valuable con- tributions in the establishment of the law of metamor- phosis of tumors. Among the early observations of the transformation of tumors were those of Sir Astley Cooper, who, in commenting upon “chronic mammary tumors,” said: “Although these tumors are not in their commencement malignant, and they continue for many years free from the disposition to become so, yet if they remain until the period of the cessation of menstruation they sometimes assume a new and malignant action.” While both the diffuse and circumscribed adenomta tend to carcinomatous transformation, those adenomata which contain an excess of fibrous tissue tend to sarcomatous transformation. The existence in the same breast of cir- cumscribed and diffuse adenoma has been verified by Broca. The coexistence too of benign and malignant tumors in the same individual and even in the same Organ has frequently been demonstrated, and examples thereof have been given by several authors. The writer has observed a sufficient number of breast tumors with long periods of latency, to warrant him in thinking that FARLY EXTIRPATION OF TUMC).R.S. 173 most of these may have been Originally adenomata, and that probably many carcinomata begin as diffuse ade- nomata. Benign circumscribed adenomata of the breast recur after extirpation in a considerable proportion of cases, without, however, causing general infection ; but those adenomata that have become malignant are soon followed by general infection, while most of the adeno- mata of internal Organs are malignant from the begin- ning. Modern writers on tumors agree that not only circum- scribed adenomata, which so often remain stationary for a long time, but most of the other benign tumors are liable to become malignant. Thus, warts, moles, and other growths upon the face or body have been observed to undergo cancerous metamorphosis many years after their appearance. The late Dr. A. C. Post cited the case of a patient who had a mole that underwent car- cinomatous transformation forty years after it had been first noticed, and advocated the removal of “morbid growths which seem to be in themselves capable of no harm.” Fibrous tumors are often transformed into Sarcomata. Primary sarcomata are said to be rare, particularly in the breast, for, in the majority of in- stances, they are believed to begin as fibrous tumors which, remaining stationary for variable lapses of time, finally undergo sarcomatous transformation. In myxo- mata and myomata, an accession of sarcomatous element is not infrequent, the tumors so metamorphosed being Commonly named myxosarcoma in the one case, and myOSarcoma in the other case. Lipomata are some- times metamorphosed into myxomata and sometimes into sarcomata. Some years ago the writer extirpated a large lipoma, nearly half of the bulk of which had undergone sarcomatous metamorphosis. It is well known that when mammary adenomata be- become malignant, such epithelial hyperplasia as may Cause carcinoma does not always occur, for it sometimes happens that the regressive metaplasia is in the con- 174 NEW YORK STATE MEDICAL ASSOCIATION. nective tissue framework of the acini and tubes, Sar- coma being the result. This sarcomatous element generally invades the tumor only in part, and consti- tutes a variety and not a new species, as for instance, the so-called adenosarcoma, the malignant transfor- mation occurring in the fibrous tissue, which is, per- haps, already in excess and not among the epithelia of the acini or of the tubes. So long as a tumor retains a comparatively high degree of organisation it remains benign, but when its constituent tissues are disturbed there is apt to be an accession of tissues of a low grade of organisation, and the tumor becomes malignant ; the lower the organisation, the greater the malignity. 3. In setting forth the reasons why it is believed to be improper and unwise to delay operative interference for the cure of tumors, it may be well to include a brief state- ment of the principal methods of general and local treat- ment from time to time employed. Many surgeons, ever since the beginning, of this century, have tried in vain both the general and local treatment of benign and of malignant tumors. The general treatment has consisted in the adminis- tration of mercurial preparations, of potassium iodide, of purgatives, of hemlock, of red-clover tea, of thuya and hydrastis tinctures, of Chian turpentine, or of alka- line solutions, all to no purpose. There is no trust- worthy evidence that a single case has ever been cured by these or by any other drugs. Those who stubbornly rely upon exclusive general treatment in the manage- ment of tumors, only imperil the lives of their patients, for, thus allured, the sufferers temporise until it is too late. Local medication leads to no better end, but is still resorted to by many because it has been advocated by Some eminent surgeons who scarcely imagined what might be the extent of the mischief indirectly caused by this advocacy, although it was not without qualifi- cations, and although most of them had afterward ac- EARLY EXTIRPATION OF T'UMORS, 175 knowledged the failure of local treatment by poultices, plasters, unguents, leeches, ice, etc., and had finally advised excision as the most rational mode of cure. Un- fortunately, by the majority, the first statement only was read, copied, quoted, and acted upon without discrimination. The qualifications were unheeded, the repudiation was unnoticed, the evil of this essentially temporising management increased, and the consequen- ces were disastrous. Plasters, unguents, arsenical pastes, nostrums of all kinds, continue to be used, much to the detriment and suffering of the afflicted. Mechanical compression was for a long time in great vogue, and is even now occasionally employed in the treatment of tumors, and is effected by means of ad- hesive-plaster strips, compressed Sponges, tight bandag- ing, etc. More than seventy years ago, its advocates went so far as to devise special instruments to compress breast tumors. Sir Astley Cooper recorded a case of mammary tumor treated by compression—at first, for several months, with adhesive strips, and afterward with a pressure instrument which “was worn during four months without advantage.” The tumor then increased with great rapidity, and in the course of six months was excised, when it had attained a weight of nine pounds. Broca has resorted to compression in some cases of mam- mary adenomata, and reported their diminution, and even believed that some of them had disappeared after a few Weeks of compression, but the cases were not afterward Observed long enough to decide the question of cure. The effect of compression was supposed to be absorption of the tumors, but there is no proof of such absorption of tumors. Cyst formation is known to be very common in tumors of the breast. Steady compression applied to these tumors sometimes causes a marked diminution of their bulk, and this diminution is generally owing to absorption of the fluid contents of the cysts, while the Solid substance of the tumors remains intact. Soon after the cessation of the compressing force, the cysts fill again, 176 NEW YORK STATE MEDICAL ASSOCIATION. and then the tumor structure is liable to grow with in- creased rapidity. For a century past, eminent teachers have promulgated the idea that so long as a tumor is causing no apparent mischief, and shows no disposition to increase in volume, it should not be excised. This precept, regarded by many as conservative, is commonly followed to the letter in the management of new growths, even by some of the recent writers on the subject. Citations might be greatly multiplied, but brief extracts from two modern teachers will suffice. Dr. S. W. Gross, who advocated without qualification the early excision of breast adeno- mata, seems to have made an exception in the case of fibrous tumors, for he says: “As fibrous tumors are abso- lutely innocent, if their true nature be determined, they may be let alone; but my advice is that they be extir- pated if they begin to grow.” It seems strange that the doctor should have sanctioned temporisation in this case, as he was known to be a strong believer in the lia- bility of the transformation of fibrous tumors into sar- comata. It is often so difficult, at the bedside, to determine the character of small mammary tumors, that the risk of waiting until they begin to increase is such that those countenancing this delay assume an unen- viable responsibility, for sudden increase in bulk of solid tumors is not unlikely to be the beginning of carcinoma- tous or of sarcomatous transformation. Mr. Bryant, in speaking of benign tumors of the breast, says: “It is not, however, necessary to remove every tumor of this kind as soon as it is discovered, for it may grow so slowly, and be so little in the way, as to render its removal a matter of small urgency. . . .” If the law of metamor- phosis of tumors, which fixes no particular time for the beginning of the transformation of benign into malig- nant growths, is valid, the non-intervention implied by Mr. Bryant is scarcely safe. Those who uttered this precept of expectancy, and the others who accepted and followed it, do not appear to have given good reasons FARLY EXTIRPATION OF TUMC).R.S. 177 why a tumor which is stationary and apparently harm- less, but liable to metamorphosis, should not be removed. In accordance with the light thrown of late upon the natural history of tumors, it is proper to inquire if this precept can be regarded as truly conservative. The well-known fact that any solid benign growth is liable to become malignant should be sufficient to induce surgeons to condemn the arbitrary expectancy which is so generally counseled, and which so surely leads to disaster. Even if a particular tumor increases without showing signs of malignity, there can be no advantage in waiting until it shall have attained a great size, as the larger the tumor the more formidable the operation for its removal. The advice that a morbid growth should not be removed because it is stationary and causes no in- convenience, does not seem to be founded on Sound prin- ciples. Because it does not produce present inconvenience gives no surety that it will not, sooner or later, cause the greatest distress, if only from its increase in size or its interference with a vital function ; but the liability to malignant transformation is what is most to be dreaded. Therefore, as a general rule, it may be considered unwise to allow any accessible tumor to so increase in size as to be damaging to the individual, or, if it be stationary, to wait until it is metamorphosed before proposing an Operation for its cure. The true spirit of conservatism is manifested by advising the removal of a morbid growth when it is benign, when it is small, when it is Stationary, when the operation for its eradication is trifling in comparison with what it must be when the tumor has attained a great size, or when the neighboring lymph glands are implicated. The modern improve- ments in inducing anaesthesia, simplifying surgical procedures, and insuring asepticism of wounds, ren- der operations safe as compared with those of former times, so that no serious harm need now be apprehended from the extirpation of most tumors. Morbid excres- Cences of all kinds, being worse than useless to the 12 178 NEW YORK STATE MEDICAL ASSOCIATION. human economy, should be treated like foreign invaders, and removed before they become too mischievous. 4. Some of the advantages of the early extirpation of tumors have incidently appeared in the discussion of the first three points, but their reiteration seems proper in the conclusion of the answer to the initial question. There can be no reasonable doubt of the advantage of excising a small tumor believed to be malignant, even if this be owing only to the ease with which the operation can be executed, or to the slight degree of violence in- flicted upon the parts as contrasted with the magnitude of the procedure needed for the ablation of a growth which has attained great dimensions, or which has in- fected the adjacent lymph glands. For a long time past there has been a prevailing belief that extirpation of a quiescent malignant tumor only serves to stimulate the extension of the disease. But this belief does not appear to have been founded upon trustworthy clinical observations or pathological data. It is undoubtedly true that any incomplete cutting oper- ation upon a malignant tumor, or its partial cauterisation with silver nitrate or arsenic, only serves to stimulate its extension, but complete extirpation, including the adja- cent connective tissue, fascia, and lymphatics, does not leave behind any disease to be extended. Recurrence of the disease in this case would take place after cicatrisa- tion of the wound, and would be by new cell-proliferation and not by extension. External cancerous tumors have been excised, and in the course of a few weeks the patients have died of internal cancer; but in these cases, if the internal had not antedated the external disease, the met- astatic process had surely begun before the operation, and would scarcely have occurred had the tumor been excised five or six months before. The main question, however, relates more particularly to the early excision of benign tumors, of those of doubt- ful character, and of the potentially malignant tumors during the earliest period of their stage of benignity. It EARLY EXTIRPATION OF TUMC).R.S. 179 is in respect to the propriety of early excision of these several tumors that surgeons still differ in Opinion. Since it appears, from analysis of the observations of Surgeons of long and vast experience, that a large proportion of benign tumors in time become malignant, and that most malignant tumors have a stage of benignity, there should be no hesitation in advising the extirpation of these tumors as soon as discovered, and this advice may be regarded as the very essence of conservatism and of prophylaxis. From a purely aesthetic point of view, it is of no little consequence to minimise scars resulting from the excision of tumors of the face, neck, arms, or hands, particularly those occurring in the gentler sex, and this can be best accomplished by the timely removal of such morbid growths as are likely to increase to the extent of greatly disfiguring the patients. It should, however, be noted that almost any scar is better than an ugly tumor. During the spring of 1892 the writer excised a super- ficial, circumscribed, ovoid, and lobulated mammary ade- noma of two years' standing and only an inch and a half in mean diameter, from the upper and inner part of the left breast of a young lady of twenty-one. The wound, two inches in length, healed primarily. The scar is so situated as not to be visible when a low-necked dress is worn. The operation was performed thus early with the view of minimising the scar and with due regard to pro- phylaxis. For many years past the writer, like others, has adopted the practice of excising such tumors as soon as discovered, and he has no doubt that thus many growths have been nipped in the bud, which in time Would probably have become malignant. The naevi that appear upon the faces of infants, though benign, often grow so rapidly as to constitute serious disfigurement, and to require operations which leave extensive scars. If before these little vascular tu- mors COver a space of more than two or three millimetres they are promptly destroyed with the thermo-cautery, 180 NEW YORK STATE MEDICAL ASSOCIATION. the ensuing scar is likely to be almost imperceptible. The operation is completed in a few seconds and the pain is very slight. 4. The greatest mischief arises from temporisation in the case of small epithelial growths upon the lips. The ad- viser, perhaps uncertain as to the nature of the growth, waits until he can be sure of the diagnosis, suggests local remedies or sometimes even cauterisation with nitrate of silver, which causes the most rapid extension of the disease. There is then no doubt as to the char- acter of the growth, for the ambient lymphatics are already involved. The tumor is excised, but too late, and the disease soon recurs. Any tumor of the lip Of doubtful character should unhesitatingly be removed. As a general rule, the subsequent dissection and micro- scopical examination of the tumor shows the operation to have been justifiable. Early excision is the surest means of obtaining a long period of immunity from re- currence. In the experience of the writer, excision of labial epitheliomata has given immunity from recurrence varying from five to sixteen years. In some of the cases the operation was not performed as early as it would now be done, but they were all apparently free from lymphatic involvement. In a case of nasal epithelioma the exact period of immunity could not be determined. The patient was last seen nine years after the operation and was then well. The period of immunity from recurrence of the disease after operation is very variable even in the same species of tumor, and is doubtless influenced by the time of the operation ; the earlier the operation the greater the chances of prolonged immunity. In carcinoma the average period of immunity is stated by some observers to be three years and a half, and by others seven years. The extremes are three months and forty years. The writer has reported cases in which the periods of immunity varied from seven to forty years. A little reflection upon these facts naturally leads to a cautious FARLY EXTIRPATION OF TUMC) PS. 181 prognosis in a large proportion of cases. As soon as a tumor recurs, when it is still small, painless, and apparently harmless, it should be extirpated. The moral effect of this timely operation is generally good, bodily comfort is thereby promoted, and life is pro- longed. It is therefore wise to operate as often as the tumor recurs. Dr. Valentine Mott reported a case of recurring “malignant sarcoma’’ of the side that had been extirpated fifteen times in twenty-three years. For the first twenty years eight operations were performed upon the man, and the intervals of freedom from the disease averaged three years. During the remaining three years of his life seven operations were performed, and the intervals averaged four months. Dr. S. W. Gross recorded a case of recurring sarcoma excised by his father twenty-three times in four years. The woman was alive and in good health ten years and nine months after the last operation. Mr. Bryant cites a case of lipoma over the left hip, “atrophic carcinoma, '' of the left breast, and sarcoma of the right breast in a Woman sixty-four years of age. He removed the right breast, and in about six months there was a recurrence of Sarcoma in the scar. In the course of four years and a half from the first operation the disease had recurred in all sixteen times, and sixteen operations were performed for its cure. At last accounts the patient’s general con- dition was good. The carcinoma of the left breast and the lipoma of the hip were not excised. The annals of Surgery of all countries contain reports of cases of undoubted malignant tumors, after whose excision the periods of immunity from recurrence have varied from ten to thirty-five years. Malignant tumors of long bones or of their periosteum, such as sarcomata, demand the most prompt and radical Operations. Nothing less than the amputation of a limb offers the slightest chance for any prolongation of the period of immunity from recurrence of the disease. Cir- Cumscribed tumors, however, in the soft parts of a limb 182 NEW YORK STATE MEDICAL ASSOCIATION. may sometimes be enucleated without impairing the usefulness of the limb ; and, if the operation be per- formed at the earliest period of the manifestation of the disease, there may be no recurrence for a long time, or there may be a permanent cure, as in the case of a benign fibrous tumor. According to the observations of many experienced surgeons, the average duration of life is a little less than three years from the first appearance of the tumor in cases of breast carcinomata that have not been subjected to any treatment. Does this not indicate the wisdom of prompt action in the great majority of cases, since the shortest average duration of life after operations which were not performed during the stage of benignity of the tumors is three years and a half, and since it has been shown that early operations afford the best chance for many years of immunity from recurrence % Very large tumors are now rarely seen in comparison with the great numbers recorded before the introduction of ether, nitrous oxide and chloroform as anaesthetic agents. The dread of surgical operations was formerly so great that patients were ready for the use of any means proposed rather than the knife, although many of the modes of treatment employed were cruel in the ex- treme, far exceeding any torture that could have been inflicted with cutting instruments. At length, when every method of cure failed and the tumor had attained great dimensions or was in a state of ulceration, the knife was used as the last resource, sometimes success- fully, but generally without avail. The excision of breast tumors of fifteen and twenty pounds weight, and of fatty tumors of twenty and thirty pounds, was not an uncommon operation. Fibrous tumors weighing one hundred pounds and more were then often excised. Thanks to the several modern modes of inducing anaes- thesia, the patients of to-day need have little fear of the knife, for they are assured that they will be rendered insensible to pain during and for a time after operation. JARLY EXTIRPATION OF TUMC)RS. 183 O The surgeon, conscious that he is inflicting no pain, is then able to give his whole attention to the work in hand, and performs the operation in accordance with the recent improvements in surgical procedures and with the best modes of insuring asepticism of the wound. The categorical answer to the initial question is, that at the earliest period of the development of any acces- sible tumor its complete extirpation is not only justifi- able, but should be regarded as an eminently conservative and equally humane act, The results of the examination of the four points pro- posed for consideration in the discussion of the initial Question, may be summarised as follows: 1. Malignant tumors exceed benign tumors in fre- Quency. 2. The malignant tumors comprise epitheliomata, Sar- comata, and internal adenomata. 3. Among the bening tumors, myxomata and external adenomata often recur after excision, but do not infect the system. 4. There is no solid benign tumor that may not become malignant. 5. No means are known by which can be ascertained the precise time of the beginning of metamorphic action in tumors. 6. Most malignant tumors have a stage of benignity. 7. Excision of potentially benignant tumors in the early epoch of their stage of benignity is likely to effect a permanent cure, or, at least, to prolong greatly the period of immunity from recurrence of the disease. 8. In the excision of malignant tumors, the greatest Care should be taken to remove as much of the ambient tissues, including fasciae and lymph glands, as is com- patible with good judgment. 9. General treatment of tumors has no value except as an adjuvant of a surgical operation, and is often indirectly injurious, leading the patient to expect a cure 184 JWE W YORK STATE MEDICAL ASSOCIATION. by persevering in the use of drugs, and thus allowing the disease to make rapid progress toward a fatal end. 10. Local treatment of tumors, by means of escharotic plasters, pastes, or powders, is the most fruitful in evil of all the devices for the torture of the afflicted. The plaster, paste, or powder causes the greater part of the tumor to slough, but there is enough left behind for the most rapid extension of the disease. The effect of the escharotic is, therefore, only to till a soil where new growths sprout like so many seed cast upon rich loam. 11. Compression is delusive in the case of tumors con- taining cysts, and is directly hurtful by exciting the rapid growth of most tumors. 12. Expectancy, even in the case of benign tumors, is as unwise as meddlesome medication. 13. There should be no waste of time in endeavoring to make a precise diagnosis of a particular morbid growth, for, after its excision, the microscope reveals the nature of its constituent elements, and assists in the establishment of the prognosis, which is the question of greatest importance to the sufferer. 14. What is known of the great fatality of tumors of long Standing, should induce surgeons to advise the com- plete removal of all accessible morbid growths as soon as detected, no matter how seemingly trivial or harmless; Such as, Small glandular, fatty, fibrous, and vascular tumors, wens, warts, moles, etc. 15. As soon after excision, and as often as a tumor recurs, it should be removed, so long as there is any possibility of insuring cicatrisation of the wound, even by skin-grafting. 16. Medicinal treatment after the excision of malig- nant tumors, is of much value, even if it consists only in the administration of reconstituent medicines. DISCUSSION. DR. CHARLES PHELPs, of New York county, said that it seemed to him one of the curiosities of medical science, that demonstrated facts should be made the subject of discussion. He did not think there was any I) ISO/USSION. 185 question about the transformation of tumors being a thoroughly estab- lished fact, and this being the case, there should be no question about the propriety of the early extirpation of all tumors, especially in consideration of the fact that with our present methods of antiseptic surgery, very few operations in the whole range of surgical procedures are, in themselves, at all dangerous. The experience of each could doubtless furnish many instances where the removal of tumors has been neglected with disastrous results, and he could not see how any surgeon of experience could believe, teach, or practice, that tumors should be allowed to grow to a certain size before their removal. There is no more danger of extension because of the thorough removal of the original growth, than there would be if it had been allowed to remain. Dr. Gouley's paper was exceedingly important and valuable, and one likely to be of service to the profession at large, who were still sufficiently conservative to cling to the old idea, that while tumors are causing no disturbance they should be left alone. DR. Josh PH BRYANT, of New York county, said it was the duty of every One dealing with malignant growths, to embrace this opportunity, after the forcible presentation of the subject by the author, to express them- Selves, not only as to their own belief on the matter, but to solemnly pledge themselves to act on the proposition. There can be no question that if the diagnosis were made more promptly, and less sentiment regarding the presence of tumors in the human economy, were exhibited, both by their possessors and by their family physicians, the death-rate following opera- tions on such growths would be very greatly decreased. Every one who has been in practice any length of time has met with this feeling, and has Seen the strenuous efforts made to keep the fact of the presence of a tumor a Secret. Unfortunately, the physician too often encourages this senti- ment, instead of urging the person to have the tumor removed, if it be at all accessible. Quite recently he had advised an exploratory incision in the case of a young lady with a mammary growth, the exact measures to be adopted at the time of operation, to depend largely upon the physical Characteristics of the tumor and its association with the gland. Of course the young lady objected strongly to the removal of the tumor, because she feared permanent disfigurement, but when assured that the history of the grOWth did not indicate malignancy, and that probably only a portion of the gland would require removal, she submitted gracefully; the growth Was removed, and found to be an adenoma. If this had been permitted to go on, the chances are that it would have become, in time, actually malig- nant, and eventually the whole breast would have been sacrificed. Again, a lady came to his office with a large, fibrous tumor located in the lower end of the femur, between the quadriceps and the bone. It was removed, and found to contain six small isolated spots of beginning sarcomatous change. When this change began no one could tell, but it is probable that it commenced at that time when the history showed there had been an in- crease in the rapidity of growth. When one considers our ignorance of the time when constitutional infection takes place, it is evident that great risks 186 NEW YORK STATE MEDICAL ASSOCIATION. are assumed by delaying operation. He would not say that we should at Once remove small naevi or “mother's marks,” in infants, as we know that such growths often rapidly disappear of themselves; but in the event of their increasing in size, he would certainly remove them as soon as he could convince the parents of the propriety of such a procedure. The earlier malignant growths are removed, the more certain their permanent expul- sion from the system ; and the later they are removed, even though this appears to be thoroughly done, the Sooner will be their return, and the more malignant will be the secondary manifestations. He desired to ex- press his approval of the paper, and to say that every physician who has patients with tumors, should avoid aiding them in concealing the fact, and should never enter into any sentimental consideration about whether they are, or are not malignant, but advise at once and most emphatically the prompt removal of the growth. REMAIRKS ON A NEW METHOD OF INTES- TINAL ANASTOMOSIS. By BENJAMIN M. RICKETTs, M. D., of Cincinnati, Ohio. Movember 16, 1892. (From the Stenographer's Notes.) Dr. Ricketts said that in a paper read by Dr. J. P. Murphy, of Chicago, before the Mississippi Valley Medical Association, three weeks ago, the author de- scribed a new method of making intestinal anastomoses, both lateral, and end to end, and of performing cholo- cystotomy by the use of a little “button” which he had devised for this purpose. The idea involved in its construction is taken from a popular form of glove fast- ening, in which one portion fits into the other, like a plug into a socket. In the device under consideration, this “plug’’ is, of course, made with a central opening. It is made in sets, of three different sizes, by Haussman & Dunn, No. 220 Madison street, Chicago. A button of the proper size is selected, and the gut clamped with a pair of phimosis forceps, secured with rubber bands. This prevents the escape of the intestinal contents. The gut is then simply puckered up around the button, by means of a thread, one-half of the button being thus Secured in each portion of gut, so that when the portions of gut are joined together, this button is on the inside, and can therefore slough away, and escape through the intestinal canal. Dr. Murphy began operating according to this method, last April. He has successfully per- formed one operation on a woman, for gall-stones, leav- ing the stones, in the bladder, and allowing them to pass Out afterwards. The gall-bladder will contract, and expel them, so that there is no danger of their being left there. 188 NEW YORK STATE MEDICAL ASSOCIATION. Since the reading of this paper, the speaker had been engaged in experimenting with the button upon dogs. Two weeks ago, he made an end-to-end anastomosis of the colon, in a large mastiff, and he had brought enough of the gut from this animal with him, to enable him to demonstrate the method of doing the operation. He thought this method would revolutionise this kind of surgery, and would also be extremely useful in cholo- cystotomy, as instead of occupying from two to two and a half hours, it could be done in a few minutes, and thus much shock avoided. The button, which he had with him, was made of brass, but of course it could be made of aluminium, or other suitable metal. Dr. Ricketts then demonstrated the method of using the button in making an end-to-end intestinal anasto- mosis. A REPORT OF SOME CASES OF COMPOUND DEPRESSED FRACTURE OF THE SKULL. By GEORGE D. KAHLO, M. D., of Indiana. November 16, 1892. It was my intention when accepting the invitation of your Association to present a paper before this meeting, to make simply a clinical report of the cases of compound depressed fracture of the skull which came under my care, during a service as house-surgeon at the Harlem Hospital, New York. Through the courtesy of Drs. T. H. Manley and C. B. White, visiting surgeons at the hospital mentioned, I have, however, been permitted to embody in this report statistics regarding all the cases Of this kind which have been treated at that institution since its opening in 1887. I have endeavored, therefore, to make these histories as brief as is commensurate with an accurate statement of the symptoms which they pre- Sented, and will conclude with a few remarks upon what appear to me to be the special points of interest to be gathered from all. CASE I. A boy, seventeen years of age; admitted to the hospital May 25, 1891. While standing on a scaffolding supported from the top of a two-story building, he fell to the ground, a distance of about ten feet, pieces of the broken cornice and bricks striking him as he fell. At the time of his admission, there was complete loss of consciousness, but he was not Comatose. There were signs also of quite a profuse haemorrhage from the right ear, but the bleeding had entirely ceased. A large haematoma was found covering nearly the whole of the right side of the skull, and there Were two Small scalp wounds, each about a quarter of an inch in length near the seat of the lower and posterior angle of the parietal bone. There Was no paralysis, the pupils were equal and responded quickly to light. Palpation of the scalp gave distinct crepitation over a considerable area. After the administration of an anaesthetic, and shaving and cleansing the Scalp, I made a semicircular incision, its convexity downwards, extending from about the centre of the coronal suture to a point corresponding with 190 NEW YORK STATE MEDICAL ASSOCIATION. the articulation of the occipital with the parietal bones. Upon elevating the periosteum, I found a fracture radiating in every direction, and involv- ing almost the entire right parietal bone; it extended anteriorly to a point just above the supra-orbital arch of the frontal bone, posteriorly and below, into the mastoid process and petrous portion of the temporal bone. There was another line of fracture extending upward and backward into the upper and posterior angle of the parietal bone of the left side. There were in all seven different fragments, two of which were entirely detached; one at the lower and anterior portion of the parietal bone, rectangular in shape, measuring about three-fourths by one and one-half inches, and the other, just above and posterior to it, triangular in shape, about an inch in its longest and three-fourths of an inch in its shortest diameter. The latter was depressed at its lower and posterior border about one-fourth of an inch ; the others, with two exceptions, were in their normal positions, and these were slightly elevated upon one side. With a periosteal elevator, the depressed fragment was elevated and removed, and where there was any over-riding of the edges, these were adjusted to the normal contour of the skull. The other fragment which was detached, owing to its large size, I allowed to remain in the position in which I found it. The dura mater had not been injured at any point, and after irrigating the parts with sterilised water, and the introduction of a few strands of horse-hair for drainage, the wound was sutured together with silk, taking up the perios- teum with the scalp. A rubber ice-helmet was now applied. A few hours later, his condition, which, up to this time, had been one of great restless- ness, changed to that of active delirium. He tossed his head about, cried out incessantly, and became more and more maniacal during the next three days, and required to be restrained in bed throughout the whole of the first week. After the third day, there were no manifestations of violence, but he talked constantly, night and day, and in a very rambling and incoherent manner, evidencing the most varied delusions and hallucinations. At times he seemed to recognise friends who visited him, but he was not at all rational. The dressings were changed the day following his admission, and the drainage removed. Fresh dressings were also applied at frequent intervals thereafter, sometimes as often as three or four times a day, on account of the great restlessness of the patient. The wound healed by first intention, and all dressings were discontinued after the eighth day. Beyond the treatment already mentioned, calomel was occasionally administered and the catheter was passed at regular intervals during the five days in which there was retention of urine. The greatest difficulty was experienced in controlling the delirium. He was given potassium bromide in twenty- grain doses, at intervals of three hours, with no apparent effect, and mor- phine, unless administered hypodermically and in large doses, was scarcely more efficacious. I next tried a hypodermic injection of one-eighth of a grain of hyoscyamine. The first dose showed no effect whatever, but on repeating it after an interval of four hours, I was much astonished at the sudden development of what at first appeared to be serious symptoms of the toxic effect of the drug. The pupils were widely dilated, there was a FRACTURES OF THE SHOULL. 191 dark-red efflorescence on the skin, a rapid pulse, marked increase in the frequency of respiration and in the delirium. I immediately administered a hypodermic injection of one-sixth of a grain of morphine, which was fol- lowed in a short time by a quiet sleep of about four hours, and a gradual Ces- sation of the symptoms mentioned. The following day I ordered a mixture containing in each dose twenty grains each of sodium and ammonium bro- mide, and five minims of the tincture of opium. This was repeated every four hours, and gave the best results. The dose was gradually reduced and the intervals extended, until the fourteenth day, after which no seda- tive of any kind was found necessary. His condition at this time was that of acute dementia. He would sit up in the ward and appear quite rational at times, but would quickly return to his rambling talk. He was then put upon a general tonic, and his condition, both mental and physical, showed signs of daily improvement until the date of his discharge, which was on the seventeenth day. It was not until about a week later that his mental faculties were entirely restored. Since that time, with the exception of an occasional headache for the first few weeks following his discharge, he has suffered no ill effects from the injury. CASE II. A boy, seven years of age. He fell from a third story win- dow to the pavement, a distance of about thirty feet. When admitted, he was unconscious, and there were signs of a profuse haemorrhage from the right ear, but there was no paralysis or inequality of the pupils. There was a scalp wound about one inch in length, two inches above, and on a line with the right external angular process of the frontal bone, through which the fracture could be distinctly felt. An anaesthetic was adminis- tered, and, after shaving the scalp, I enlarged the wound to about double its original length, and then made a second incision of about equal length, at right angles to it, beginning at its posterior angle and extending upwards towards the median line. Upon lifting the flap, I found a fracture beginning about one and a half inches above the centre of the right orbital ridge, extending back through the frontal and parietal bones for about two inches, making a curve downwards toward the ear in its course, and then turning abruptly in the direction of the median line to a point about one-fourth of an inch from it. The only point of depression Was at the lower and posterior angle of the inner fragment, which was depressed fully one-third of an inch. I then chiseled away a small por- tion of the outer fragment, and with a periosteal elevator, raised the de- pressed fragment until both were on the same plane. The wound was then irrigated with sterilised water, two strands of coarse catgut being intro- duced for drainage, and then closed with interrupted silk sutures which in- cluded both the scalp and periosteum. The ear was packed with iodoform gauze, and the usual surgical dressings applied. The application of an ice- Cap Was the only treatment he received beyond the re-dressing of the wound, Which was done on the fourth and eighth days; after this, no dressings were required, as the wound had healed by first intention. The patient returned to consciousness immediately after coming out of the ether. The second 192 NEW YORK STATE MEDICAL ASSOCIATION. day, there was marked ecchymosis over the right eye, and a day or two later, it was noticed that he had developed internal strabismus of the same eye. He had no rise of temperature, and his convalescence was rapid and uneventful. He was discharged on the eleventh day. CASE III. A man, thirty-eight years of age, was struck by a brick which had fallen from the fourth story of a building, a distance of about forty-five feet. The blow knocked him down, but he quickly regained his feet, and at the time of the arrival of the ambulance surgeon, presented no symptom of fracture. There was a lacerated wound about two and a half inches in length, extending transversely across the vertex near the articulation of the occip- ital with the parietal bones. A triangular fracture was easily made out, its apex pointing anteriorly. The sides of this triangle were each about one and one-fourth inches long, and the base line about three-quarters of an inch in length. The latter corresponded to the line of articulation of the occipital and parietal bones, being about one-fourth of an inch anterior to it ; the other two sides were in the right and left parietal bones respec- tively, crossing the great longitudinal sinus in their course, but involving rather more of the right side than the left. There was a depression of fully one-fourth of an inch at the apex of the triangle, but none at the base. Dr. Manley, who saw the case at the time of admission, inclined to the opinion, that as the fracture was immediately over the longitudinal sinus, thus involving some risk from haemorrhage, and there was an entire ab- sence of constitutional symptoms, operative interference, at least for the present, was inadvisable. Accordingly, nothing was done beyond shaving the scalp, and applying dressings, the wound being kept open by packing with gauze. The patient was allowed to go home the same day, and he returned at intervals to be dressed. The wound, however, did not entirely heal, and there remained a small sinus through which a slight amount of purulent matter continued to discharge. About three months later he re- turned to the hospital for an operation, which was performed by Dr. Man- ley, under local anaesthesia, produced by injecting into the soft parts one hundred and twenty minims of a one per cent. Solution of cocaine. An in- cision was made, two and a half inches in length, extending from the upper portion of the occipital bone on the left side, to the right parietal bone ; this was crossed by a second incision, at right angles to it, of about equal length, the fistulous opening in the scalp marking the point of inter- section of the two incisions. Necrosis had taken place in the depressed fragment, and had extended to the adjacent bone. The depressed frag- ment was now removed, and the borders of the parietal bone which had become involved, were chiseled away until only healthy structure was visible. The external wound was closed, catgut inserted for drainage, and the patient discharged on the same day, with instructions to return to the hospital to have the wound dressed. He has since entirely recovered. I wish especially to emphasise the following points in connection with the histories of the foregoing cases. FRACTURES OF THE SHOULL. 193 In the first case, the extent of the injury, the duration of the delirium, the toxic effect produced by the admin- istration of hyoscyamine, and the rapid subsidence of these symptoms on the administration of morphine, are points of special interest. In the second case, the restora- tion of consciousness and disappearance of all symptoms immediately following the operation, the development of ecchymosis and internal strabismus, and the rapid re- covery, are the important features. In the last case, the marked depression of bone without any symptoms of cerebral compression, and the prompt healing of the wound after the removal of the necrosed bone, three months subsequent to the injury, are worthy of note. I wish also to call attention to the fact, that in the second and third cases there was an entire absence of symptoms of concussion following the use of the chisel, and that in all three cases only sterilised applications were employed. At the close of this article will be found a statistical table of the fifty cases of compound depressed fracture of the skull which have been treated in the hospital. Of these, 43 occurred in the male, and 7 in the female. 16 were 10 years old or under, 17 between 10 and 20, 6 between 20 and 30, 9 between 30 and 40, and 2 over 40. The frontal bone was involved in 20 cases, The parietal in 25 cases, The occipital in 10 cases, and The temporal in 14. In 9 cases, there was also fracture at the base. 18 were on the left side, - 27 were on the right, and in 5 both sides were involved. In 18 cases the fracture was compound and depressed. In 26 it was comminuted. 5 were gun-shot injuries, and 1 was a stab wound. The dura, or brain substance, was involved in 20 cases, and paralysis Was only present in 6; in 3 of which it was a primary, and in 3 a secondary Symptom. 13 194 NETW YORK STATE MEDICAL ASSOCIATION, Of the total number, all but 6 were operated upon ; in 18 the chisel was employed, in 10 the trephine, and in 1 the Hey’s saw. The 15 remaining cases were comminuted fractures, the fragments of which could be adjusted with the use of the periosteal elevator or forceps, and did not involve the loss of bone tissue. Thirty-two of the number recovered, which would show a mortality of 36 per cent., or, exclusive of the 9 cases in which there was also a fracture of the base, this would be reduced to 18 per cent. Of the cases in which there was no injury of the dura or brain substance, the rate was 263 per cent., and of those in which one or both of these formed a complication, it was 50 per cent. In no single instance is it recorded in the history, that death could be directly attributable to the operation itself, and only one of the 6 upon which no operation was attempted, recovered. The points which have especially impressed me in the compilation of these statistics and the conclusions to be drawn from them, I would state as follows: 1st. The comparatively slight danger of the operation itself if proper antiseptic precautions are observed. Roberts' says that “the rate of mortality should not be greater than in amputations of the finger through the metacarpal bone.” - 2d. The necessity of early operation in all recent cases of compound depressed fractures of the skull, whether there be symptoms of compression or not, unless there is shock or some other contra-indication. Stimson” states that “the percentage of recovery in early opera- tive interference is high compared with tardy operation,” and cites a case similar to the last one whose history I read, in which there was injury to the great longitudinal sinus without brain symptoms. This he treated by im- mediate trephining, and the removal of about three square inches of bone, with perfect recovery. Erichsen,” in speaking of this class of cases says, with one excep- tion he has never seen a case recover in which a com- pound depressed fracture of the skull occurring in the adult, has been left without operation—one is included in the foregoing tabulation. • * Roberts: Operative Surgery of the Brain, page 15. * Treatise on Fractures, page 248. - * Moses Gunn : Transactions Am. Surg. Assn. Vol. I., p. 85. FRACTURES OF THE SHOULD. 195 I scarcely need call to your mind the many evil conse- quences of procrastination in these cases, for it is familiar to you all, that the injury to the internal table is in a vast majority of cases greater than that to the external, and I quote from Briggs," as saying that “the great danger in depressed fractures is not compression, but in- flammation set up by displaced fragments of bone;” and Erichsen” also says “the presence of depressed and spicu- lated fragments pressing upon the dura mater must inevitably and speedily induce encephalitis.” Besides this, there is in a large proportion of cases, necrosis of the fragments, and, occasionally at least, the formation of Osteophytes at the line of union between them. To the teachings of the authorities mentioned, might also be added another quotation from Roberts,” in which he says: “Without a knowledge of the true state of af- fairs, treatment is empirical; and the risk to subsequent mental health or to life, is too great to permit reliance on empirical treatment when a knowledge of the true condition is obtainable with the slight danger that per- tains to antisepsic surgery.” One point which has im- pressed me in the history of the foregoing cases and in Studying those in the table, is the absence of symptoms of compression. This is often cited as the indication for operative interference, and while believing of course that the presence of such symptoms would point most emphat- ically to the necessity for operation, I do not think that their absence should in any way be regarded as contra- indicating it. 3d. With reference to the different operations em- ployed in the condition under consideration, it will be remembered that in eighteen cases elevation of the de- pressed bone was performed by the use of the chisel, and In ten with the trephine. The rate of mortality in these Cases Was eleven and one-ninth per cent. in the former, and * Annals of Anatomy and Surgery, Vol. II., p. 69. * Ibid. * Roberts: Operative Surgery of the Brain, page 23. 196 NEW YORK STATE MEDIOAL ASSOCIATION. forty per cent. in the latter, although, as I have said, in no single instance do the hospital records give as the cause of death, the operation itself. As may be inferred from this comparison, my own preference is for the use of the chisel. This opinion is of necessity largely the result of my own experience, but I would quote the following au- thorities for the position taken : Gerster' expresses the opinion that “the trephine is al- ways an inadequate instrument, and that its use is fraught with danger to the dura.” He employs the chisel and replaces the removed chips. The substitution of the chisel for the trephine was also strongly advocated by the late Professor von Volkmann.” The objection is offered by the opponents of this instrument, that its use, especially when the force is applied with the mallet, is very apt to produce serious symptoms of concussion, and in proof of the severity of this plan it is claimed that, “while the force of one blow may be insignificant, the result of a number in succes- sion is proportionate to the aggregate of all.” Keetley * states that this objection only holds good in old people with very atheromatous arteries ; and I beg again to direct your attention to the entire absence of this symp- tom in the history of the cases which form the subject of this paper. No note of any such unfavorable conse- quence is made in any of the hospital records in which this operation has been performed. Leaving out this objection, I think it will be granted that it at least possesses the advantage of minimising the extent of bone tissue to be removed, and in my opinion, its use in inexperienced hands is attended with less difficulty and with less danger of injury to the dura. When there is much comminution of the frag- ments, and these can be easily replaced with the forceps or periosteal elevator, this plan of treatment would of 1 N. Y. Med. Journal, Feb. 21, 1891. * Berliner klinische Wochenschrift, Dec. 16, 1889. ° Med. Press and Circular, London, Dec. 31, 1890. FRACTURES OF THE SHOULL. 197 course recommend itself to all. In those cases where the object is to cut a hole of considerable size in the skull, as in operations for tumor of the brain, epilepsy, etc., the trephine is obviously the proper instrument to be employed; but in the vast majority of cases of linear fracture with depression, I believe that a very small piece may be chiseled from one fragment which will enable one with the periosteal elevator or other instrument to elevate the depressed portion with scarcely any loss of bone tissue; and Ithink it is especially indicated in those cases in which it is only necessary to cleanse the fissure from any septic material which may have obtained lodg- ment there. In conclusion, permit me also to say a word with refer- ence to the advantages of an aseptic over an antiseptic operation. The tendency of the present day to use sterilised water and sterilised dressings in preference to antiseptics is, I think, especially applicable to brain surgery; for, with careful cleansing, the wound may usu- ally be made almost aseptic, and there is less danger of irritation to the dura. I would, however, make an exception in those cases in which, from the nature of the injury, there seemed to be a special liability to the development of Suppuration, and, of course, in latent cases in which this condition already exists. ź H -: p3 ºf 3 P 2 3 SIDE OF § o º #: SEX. AGE. BONES INVOLVED. HEAD. CHARACTER, PARALYSIS. º : z \operation. RESULT. 2 * : 3 z. o sº tº Male. . . | 2 |Frontal. . . . . . . . . . . . . . . Right. Comminuted (also fracture base)|Absent. . . . . . . Yes. |None. . . . . . . Died. Female. || 3 |Parietal and Frontal. . . & & & & & & Left hemiple- gia. Disap- peared (after 5 weeks)....| Yes Chisel . . . . . . Recovered. Male. . . | 3 |Temporal, Parietal and * - Occipital. . . . . . . . . . . & C Comminuted. . . . . . . . Absent... . . . . . { { PerioSt’l ele Vator. . . . . Died. Male. . . 4 [Parietal. . . . . . . . . . . . . . . Left. Compound depressed & 4 No. 6 & Recovered. Female.| 4 |Occipital... . . . . . . . . . . . & & Compound depressed (also base). . . . . . . . . “ { { & 6 Died. Male ... 4 |Frontal. . . . . . . . . . . . . . Right. Compound depressed £ & { % Trephine. ..] Recovered. Female...| 4 & & Left. Comminuted. . . . . . . & & Yes Periost’l ele- Vator . . . . . Died. Female... 4 & 4 Right. Comminuted (also base). . . . . . . . & & No. |None . . . . . . Died. Male. . . | 5 |Frontal and Parietal. . . & & Comminuted . . . . . . . . & & Yes. Periost’l ele- vator... . . . . Recovered. & 6 7 Temporal, Parietal and Frontal * * g e º ſº & & Comminuted (also base) . . . . . . . . & & No. Hey’s saw. .. & & 4 & 7 |Frontal and Parietal...] Right. Compound depressed|Internal stra- bismus se c- - Ondary. . . . . . & & Chisel. . . . . . Recovered. É Male. . . Female.. Male. . . Female.. Male. . . & & Temporal, Parietal and Frontal. . . . . . . . . . . . . . Parietal . . . . . . . . . . . . . . Parietal and Temporal Occipital and Parietal. Frontal. . . . . . . . . . . . . . . Occipital and Parietal.. Frontal, . . . . . . . . . . . . . . Frontal and Parietal... Temporal. . . . . . . . . . . . . Frontal. . . . . . . . . . . . . . . Parietal and Temporal. Parietal. . . . . . . . . . . . . . Frontal, Parietal and Temporal. . . . . . . . . . . Temporal and Frontal. Occipital. . . . . . . . . . . . . . Frontal and Parietal... Temporal and Occipital Right & Left & & Left & Right Right. Left. Right. Left. Left. Right. Right & Left Right. ( & & 4 Left. Right. Left. Left. Comminuted. . . . . . . . Compound depressed Compound depressed Comminuted. . . . . . . . Compound depressed Comminuted. . . . . . . Comminuted (also base). . . . . . . . (Also base and other injuries). . . . . . . . . . Comminuted © o 'º e º 'º e Compound depressed Comminuted. . . . . . . . Gun-shot. . . . . . . . . . . Compound depressed Comminuted. . . . . . . . Compound depressed Comminuted tº º ſº gº tº e º º & 4 & 4 Compound depressed Gun-shot... . . . . . . . . Stab wound. . . . . . . . . Right. Compound depressed Internal stra- bismus se c- Ondary . . . . . Absent... . . . . . Absent. . . . . . . Abscess of brain. No. Yes. Trephine.... PerioSt’l ele- Trephine... . Periost’l ele- Vator. . . . . & 4 4 & Chisel... . . . . & & Vator. . . . . Trephine. . . . Chisel. . . . . . Trephine. . . . Periost’l ele- Vator. . . . . Trephine. . . Chisel. . . . . . Trephine. . . . Periost'l ele- Recovered. Died. Recovered. Died. Recovered. Died. Recovered. Died. Died. Recovered. 4 & & 4 & 4 Died. Recovered. & C & 4 ( & Died. Recovered. & & Died. Recovered. § H 4 gº tº ; : Så ### p: F. SEX. AGE. BONES INVOLVED. * CHARACTER. PARALYSIS. à Q : 2 |OPERATION. RESULT. 2 * : 3 : o 3 pd Male 23 |Frontal. . . . . . . . . . . . . . . Right. Compound depressed|Absent . . . . . . No. 1Chisel. . . . . Recovered. & 4 25 |Temporal. . . . . . . . . . . . . Left. Comminuted ... . . . . . & & Yes. Periost’l ele- Vator. . . . . Died. { { 28 Temporal and Parietal. & & Comminuted. . . . . . . . & & No. Trephine....| Recovered. & & 28 |Frontal . . . . . . . . . . . . . . ( & Gun-shot. . . . . . . . . . . Nasal primari- ly; secondary - ptosis. . . . . . Yes. Chisel... . . . . & ( & & 32 |Occipital and Parietal...] Right. Compound depressed|Absent ....... No. None . . . . . . . & 6 & 4 33 Temporal. . . . . . . . . . . . . & 6 Gun-shot... . . . . . . . . . & & Yes. Chisel. . . . . . “ (, { % 34 |Frontal. . . . . . . . . . . . . . . & C Comminuted. . . . . . . . § { No. Trephine . . . { { & & 35 |Temporal. . . . . . . . . . . . . ( & & 4 & & Yes. |Forceps.. . . . { % { % 36 Temporal, Frontal, Pa- rietal, Occipital . . . . . Left. Comminuted (also base). . . . . . . . . • & & Chisel. . . . . . Died. { { 38 Parietal. . . . . . . . . . . . . . . Right & Left|Compound depresse & 4 No. { % Recovered. * { 39 & & Right. Comminuted. . . . . . . { { O. & & 6 & { { 39 & & Left. Compound depressed & & Abscess of brain. |None. . . . . . . Died. & 4 40 |Frontal. . . . . . . . . . . . . . . Left. Gun-shot....... . . . . . & & Yes. Chisel. . . . . . Recovered. & 5 51 Parietal. . . . . . . . . . . . . . . Left. Comminuted. . . . . . . . Right hemiple- - gia secondary No. & & & & & 4 60 & & 4 Comminuted (also base). . . . . . . . Right hemiple- gia primary.| Yes. |None... . . . . Died. THE ACHIEVEMENTS OF AMERICAN SUR- GERY. By FREDERIC S. DENNIs, M. D., of New York County. November 16, 1892. MR. PRESIDENT AND GENTLEMEN OF THE NEW YORK STATE MEDICAL Association : My first and pleasing duty this evening is to acknowledge with profound re- spect the distinction which has been conferred upon me by this Association. To be selected as the orator of the evening is an honor which the writer most keenly ap- preciates. In thinking over something to say upon this anniver- sary, it has occurred to me that no subject could be chosen so peculiarly fitted to this occasion, and so well adapted to this Association and to the time in which we live, as a review of the achievements of American sur- gery. At no time, and at no place has this subject ever been fully discussed with these limitations. The advance of Surgery in general has been reviewed from time to time in connection with medicine; but an attempt to consider the advance of surgery, which is purely Ameri- Can, and to trace its influence upon the nations of the World, is a subject which is worthy our consideration. The debt of gratitude which the world owes to Ameri- Can Surgery is great, and though much has been done by other nations older than America, I shall endeavor to demonstrate that American surgery eclipses all other na- tions of the world in regard to original research, in the introduction of new methods of treatment, in the perfec- tion of older methods, in the inauguration of a complete ambulance system, and, finally, in regard to tangible results. The subject is vast, the study of it is fraught With great interest, and the result of the investigation is most gratifying. 202 JNEW YORK STATE MEDICAL ASSOCIATION. Before considering in detail any of the triumphs of American surgery, it is necessary to bear in mind the im- portant fact that our country is but still in its infancy as compared with other countries, and, therefore, any com- parison might appear greatly to the disadvantage of the younger country; but, nevertheless, taking into consider- ation this most important fact, the writer will endeavor to prove that the achievements of American Surgery chal- lenge the admiration of the world. In these days of Columbian celebration, the rise and progress of the American nation from 1492 down to the present time, has been studied and recognised and eulo- gised. The achievements in every walk of life, the innu- merable inventions, the wonderful discoveries, the mag- nificent results, have all been considered, and the sum total is unparalleled in the history of nations. In a period of four hundred years, great work has been accomplished, and to-day we stand before the gaze of the world as a nation exemplifying the truest type of Chris- tian civilisation. While all this progress has been reviewed and considered during the period of the four hundred years, the work of American surgery can only be reviewed during the past one hundred years, since previous to that time American surgery was character- ised by no discovery, or distinguished by no invention, or known by any tangible results. The Science of surgery in this country made no im- pression upon the world until the beginning of the pres- ent century, and the mighty works which it has wrought during the present century, command respect and esteem from every quarter of the globe. When the nineteenth century had dawned upon us, in the long list of brilliant men who had made the surgery of the world famous, the name of no American appeared upon that honor scroll ; but from colonial days down to the present time the names of Americans shine forth in bold relief. What our country has achieved within this period of time is a worthy subject for our study and reflection. ACHIEVEMENT'S OF AMERICAN SURGERY. 203 Without doubt, the progress which American surgery has made, is due in great part to the dissemination of her medical literature, to the formation of medical libraries, to the organisation of hospitals and laboratories, and to the foundation of medical schools. Let us consider for a moment this subject, since its importance demands attention. The great dissemination of medical literature is made apparent by a reference to Billings's statistics, which show that in the United States, at the beginning of the Revolutionary War, there was only one medical book, three reprints, and about twenty pamphlets by American authors; while to-day there are over six thousand medical books and reprints, and innumerable pamphlets. There are over three hundred and fifty books and pamphlets written and published annually by American writers, to say nothing of over five thousand journal articles con- tributed each year by our countrymen. In surgery, there were only three books by American authors prior to 1844, while to-day the surgical writings by American authors fill the shelves of every library upon the face of the earth. It has been demonstrated that in Surgery alone, in 1879–80, there were written forty-five Surgical books, and one thousand seven hundred and Seventeen journal articles. This is almost twice as many Surgical books as were written in England during the Same period, and many more journal articles. It can, perhaps, be made even more forcible, by stating that in 1879–80, there were written ten thousand three hundred and thirty-four medical books and journal articles in the United States, while during the same time in England, the other English-speaking nation, there were written Only seven thousand four hundred and seventy-six books and pamphlets. In addition to this, many of our medical text-books have been translated into other languages and have been adopted as standard text-books in foreign medical Schools. In 1879–80, there were published more medical journals and transactions in the United States 204 NEW YORK STATE MEDICAL ASSOCIATION. than in Great Britain, France, Germany, Italy, or Spain, and during these two years the total number of original articles in medical journals, and transactions, exceeded those of any other nation in the world. The wide dis- Semination of medical literature has been one important factor in the advancement of surgical knowledge in the United States. At the beginning of the Revolutionary War, there was one public medical library. It belonged to the Pennsyl- vania Hospital, and it contained about two hundred and fifty volumes ; to-day, there are over one hundred thousand medical works in medical libraries in the United States. At that time there were no hospitals, no laboratories, no training-School for nurses, no medical colleges; to-day hospitals crowd every city and large town, while over a million dollars have been devoted lately to the establishment of laboratories. There are Over a hundred organised training-schools for nurses. At that time there were in the United States about two hundred medical men in practice, who had graduated from foreign schools; to-day, there are nearly one hun- dred thousand medical men distributed throughout the length and breadth of this vast country, who are gradu- ates of our own medical schools. At that time there were two medical schools in the embryo; to-day there are Over one hundred medical schools in the United States. At that time there was one quarterly medical journal; to-day America has the largest proportion of monthly medical journals of all the nations of the world, and nearly twice as many of all kinds as England, the other English-speaking nation. One of the best instances illus- trating the progress of American medical journalism, is the enterprise of the MEDICAL RECORD in cabling the entire transactions of an International Medical Congress for the benefit of the American medical profession. At that time there was scarcely a medical society in exist- ence, to-day there are over one hundred recognised and well-established State and County medical associations. ACEIIETVEMENT'S OF AMERICAN SURGERY. 205 At the beginning of the Revolutionary War there was not a single medical museum in this country ; to-day there are over twenty large, well-organised medical museums, containing in the aggregate, Seventy thousand gross specimens, and for the maintenance of which over $70,000 is expended annually, or one dollar a year for the preservation of each specimen. This fact alone is a convincing proof of the progress which American sur- gery has made, since the establishment and use of a medical museum is an index of the thoroughness of sur- gical teaching and practice. In 1820, Sidney Smith, the great literary genius of his day, made use of the following phrases in the Edinburgh Review) : “Americans have done absolutely nothing for the sciences. . . . In the four quarters of the globe, who reads an American book? . . . What does the world yet owe to American physicians or surgeons Ž What new substances have their chemists dis- covered ''” I shall take this remarkable passage and transpose it so as to form the different heads of my address this evening, and thus reply to this challenge of Sidney Smith. It will be my endeavor to demonstrate, that American surgery, as a science, has done much to contribute to the welfare of the human race instead of “absolutely nothing.” I shall show that many nations of the world “read American books; ” and, finally, I shall point out what “new substances their chemists have discovered,” and what the world owes to “Ameri- can physicians and Surgeons.” In reviewing the progress of surgery in general, there are two things which must not be overlooked, since they have been instrumental in bringing about this great utopia in surgery. The first is the introduction of anaesthetics, which has eliminated shock, and the second is the intro- duction of antiseptics, which has eliminated sepsis. The Science of surgery has thus eliminated the two great Causes of death after surgical operations, viz., shock and Sepsis. A new era now dawned upon the profession and 206 MEW YORK STATE MEDICAL ASSOCIATION. the field of operative surgery was vastly widened, the results were made uniformly certain, and new operations were performed which hitherto were considered outside the pale of legitimate surgery. These two beneficent discoveries thus form the two pillars to the triumphal arch. In the pursuit of our subject, it is most pertinent at this point to inquire into the influence that this coun- try has exercised in effecting these two great reforma- tions. . 1st. The Introduction of Anaesthetics.=This great event has cast a widespread influence upon the progress of surgery. In 1842, Crawford W. Long, of Georgia, re- moved a tumor with the patient under the influence of an anaesthetic. No further attempt was made until 1844, when Wells had a tooth extracted while insensible with nitrous oxide gas. Morton, at the suggestion of Dr. Jackson, anaesthetised a patient on October 16, 1846, while Dr. J. C. Warren removed a tumor from the patient’s neck. From this time on, anaesthesia, hitherto a dream, now became a living reality. This is neither the place nor the time for a discussion as to the merits of the three men whose names are in- timately associated with this great discovery. To Jack- son, Morton, and Wells, in alphabetical order, the pro- fession is indebted for this great boon to suffering humanity. For our purposes to-night the work of each of these men is duly acknowledged. No other nation has succeeded in establishing a claim to this honor. It rightly belongs to us, and the influence of this dis- covery has had a most important bearing upon the rise and progress of surgery. This discovery has been the great divide, toward which, and from which, all the advances in surgery throughout the civilised world have been accomplished. It is but fair to claim that all the influences emanating and flowing from this discovery, should be attributed to it, and since this concession is granted by the world, the progress which surgery has made from decade to decade, owes its origin to an AOHIEVEMENTS OF AMERIOA.W SURGERY. 207 American discovery. That it is possible to conceive that anaesthesia might have been born in Some other country, if its birthplace had not been here, is readily admitted, but since this great agent for the relief of pain was dis- covered here, to us properly belongs all the credit which flows from it. There is one sad event connected with the greatest discovery for suffering humanity, and that is the melan- choly termination of the life of each of the three men associated with the discovery. Jackson died insane; Morton died without worldly means; Wells became a pauper, and was arrested in New York city as a crim- inal, for throwing vitriol. He was sent to jail, and there committed suicide by cutting his femoral artery. The tragic termination of life in the case of Jackson, Morton, and Wells, men to whom the world owes a lasting debt of gratitude, is in marked contrast to the beneficent, grand, and glorious work to which their discovery has led. It is interesting to note in this connection, that Sir Edward Jenner, the discoverer of vaccination, was awarded $225,000 for his discovery, by an act of Parliament, while by no act of the United States Government has anything been done to perpetuate the memory of these three men. The physicians of Hartford have erected a statue to Wells, and to them are due the grateful thanks of a nation, for their interest in preserving the memory of their fellow-townsman. It is not possible to form an intelligent estimate, or eVen an adequate conception of the sum total of human suffering and distress which has been prevented by the introduction of anaesthesia. This American discovery is the greatest contribution to surgery which has been made by any nation in the world. To Sidney Smith's interrogatory, “What new substances have their chem- ists discovered 7” the answer comes thundering down the ages—the greatest discovery of any chemist in the World, is the American discovery of a substance to pro- duce anaesthesia. 208 NEW YORK STATE MEDICAL ASSOCIATION. 2d. The Introduction of Antiseptics.-This wonder- ful discovery, which has so largely influenced the prog- ress of Surgery, belongs to no one nation exclusively. In France, Pasteur made the discovery that putrefaction was due to the presence of micro-organisms. In Scot- land, Lister made the application of this science to surgery, and to him is due immortal praise. In Germany and in the United States, the further application and the perfection in the technique were made. The subject of antisepsis, therefore, has been an evolution in which all countries have taken a part, and the complete consum- mation of which has been participated in by all nations. There are some remarkable facts connected with the early surgery of this country as foreshadowing the introduc- tion of antiseptics. For example, absolute cleanliness was a characteristic feature of Mott's surgery. He was scrupulously careful about washing his hands imme- diately prior to performing any surgical operation, and every instrument was thoroughly washed just before use. The employment of animal ligatures in this coun- try anticipated their general adoption as an essential part of antiseptic technique of the present day. Dorsey, in 1844, successfully ligatured large blood-vessels with buckskin and catgut ligatures, and after him Hartshorne employed ligatures made of parchment. Jameson used ligatures made from deer-skin. The use of the germicide, as an antiseptic, was want- ing ; still the American surgeons in early times, cer- tainly employed some of the meams which to-day include an important part of antiseptic technique. With this introduction, and also with a reference to the influence of the discovery of anaesthetics and anti- septics upon American Surgery, Ishall consider, in tracing the progress or the achievements of American surgery, 1st, Surgery of the Bones and Joints; 2d, Surgery of the Vascular System ; 3d, Surgery of the Great Cavities. of the Body; 4th, Surgery of the Genito-urinary Sys- tem; and finally miscellaneous operations and other ACHIEVEMENTS OF AMERICAN SURGERY 209 topics which cannot properly be classified in the other departments of Surgery. 1st. The Surgery of Bones and Joints.-The man- agement of fractures has brought out the wonderful mechanical ingenuity which is a characteristic of the American mind. The application of the plaster-of-Paris bandage in the treatment of fractures is one of the great- est improvements of the century. To the perfection of its technique, Fluhrer's work deserves special commen- dation. The use of flexible, narrow strips of tin or zinc in the management of fractures, was devised by Fluhrer in 1872, with the object of securing immobility of the fractured bones. The strips are not designed to act as rigid supports, although incidentally, by their width (one-quarter of an inch), they oppose edgewise resistance to angular motion, when passing through or near an axis of motion. Their principal effect is by virtue of their inextensibility; not shortening or lengthening under strain, when bandaged to the limb in the principal planes of motion. They are roughened on each side by per- forations, so that they may be securely held in position by the retaining bandage. They are not designed to Serve as an accessory strengthening of an immovable Splint ; the strips themselves are the splint. The plas- ter-of-Paris or other material incorporated in the retain- ing bandages, gives to the provisional effect of the strips, durability, which, of course, cannot be obtained by a simple bandage. In the application of the strips, the limb, in simple fractures, is first neatly and evenly covered with some material over which is applied a compressing plaster-of- Paris bandage. The strips, placed in proper position relative to the planes of motion, are bandaged to the limb as far as the site of the fracture, and, from their flex- ibility, adapt themselves to the varying contour of the limb. The fragments are then accurately adjusted in position, and as soon as the bandage is carried up the limb, firmly retaining them in relation to the upper 14 210 NEW YORK STATE MEDICAL ASSOCIATION. fragment, the immobility of the fragments is secured. In this procedure, the adjustment of the fragments in position is accomplished, while the outlines of the limb, the principal guide to a correct co-aptation of the bones, are unobscured by dressings, and the frag- ments are immobilised in the shortest time. In the treatment of fractures of the shaft of the femur, special apparatus is necessary in order to properly apply the strips, and for the construction of the pelvic portion of the permanent splint. The antiseptic treatment of Open wounds, having prac- tically brought compound fractures into the class of simple fractures, so far as relates to their treatment with permanent apparatus, has thereby widened the range of usefulness of the strips by the extension of their appli- cability to the treatment of these injuries. In compound fractures, the wound having been antiseptically treated, the covering of the limb is made by an even sheet of antiseptic material. The sterilised strips are retained by another layer of this bandage. The fragments having been thus immobilised in correct co-aptation, while the outlines of the limb are distinct, the antiseptic dressing can then be increased in bulk to meet the necessities of the wound. The work of Dr. James L. Little in the use of plaster- of-Paris bandages must not be overlooked, since he uti- lised this dressing for various fractures, and perfected several dressings for special fractures, notably the pa- tella. This plan has superseded all the clumsy methods in vogue in other countries. Time will not permit of a discussion of the manifold ways that this dressing can be employed in the different fractures. It will suffice to mention the present method of treatment of fractures of the thigh, in order to afford the best illustration of the growth and development of the plan now generally ac- cepted. If we start with Desault's splint, which was crude and unsatisfactory, the first change that occurred Was ACHIEVEMENTS OF AMERICAN SURGERY. 211 Physick’s modification, which consisted in making De- sault's splint, which reached only to the crest of the ilium, extend above to the axilla, and downward below the foot, with a perinaeal band for extension and counter- extension. In 1819, Daniell, of Georgia, introduced the weight and pulley. In 1851 Buck still further modified Physick’s splint, so as to do away with the perinaeal band, and accomplished extension of the limb by the weight and pulley, after the manner of its present use. This was a great improvement in order to overcome shortening. Van Ingen, in 1857, suggested the elevation of the foot of the bed, to permit the body to act as a counter-extending force. The co-aptation splints were used by Buck, in 1861, so that the present complete and perfect method is one that is the result of evolution, the consummation of which has been accomplished by the work of American surgeons. In 1827, Nathan R. Smith adopted the principle of suspension in the treatment of fractures, and the use of the sand-bag was introduced by Hunt, of Philadelphia, in 1862. Infracture of the clavicle, Sayre has originated a dress- ing, which is not only unique, but which is accepted as the simplest, most reliable, and most satisfactory of all the different forms of apparatus. Moore has also de- vised a very useful dressing for fracture of the clavicle, consisting of the figure-eight (8) bandage. Physick suggested the two angular splints for treating fracture of the lower end of the humerus, and Gunning and Bean, the inter-dental splint in the treatment of the fracture of the lower jaw. Dr. Oscar H. Allis first called attention to the patho- logical condition found in fractures of the lower end of the humerus, and suggested new principles in the treat- ment, to prevent deformities. In 1881, Mason devised a new method of treating frac- tures of the nasal bones bypassing a curved needle under the fragments, and elevating them. In the treatment of fracture of the patella by the use 212 INE/W YORK STATE MEDICAL ASSOCIATION. of the metallic suture, American surgery can claim the operation, as far as priority is concerned, since Rhea Earton wired a fractured patella in 1834, McClellan in 1838, Cooper, of San Francisco, in 1861, and after him, Logan and Gunn. While American surgery cannot justly claim the priority of this operation, as practiced by Lister with the modern aseptic technique, she can at least lay claim to having brought the operation to its present perfected technique, and can point to the fact that here, in New York, the operation has been per- formed more times than it has been throughout the dif- ferent countries of the world. In this city, the patella has been wired over a hundred times by Phelps, Fluhrer, McBurney, Bull, Dennis, and others, and while the operation is not one to be commended universally, it is an operation yielding brilliant results in suitable cases, and in the hands of aseptic surgeons. The first time that fractures of the lower jaw were treated by the metallic suture, was by Kinloch, of South Carolina. In the management of un-united fractures, American surgery stands pre-eminent. In 1802, Physick passed a Seton between the ends of an un-united fracture of the humerus. In 1830, or twenty-eight years after the oper- ation, Physick obtained the specimen. The use of the metallic suture was first successfully tried in 1827, by J. Rearney Rodgers, in a case of un-united fracture of the humerus. Perforation of the ends of the bones in an un- united fracture of the tibia was accomplished in 1850, by Detmold. In 1852, Brainard introduced the operation of drilling the fragments. In 1857, Pancoast used the iron screw to accomplish the same object. In the management of compound fractures American surgery has achieved remarkable results. The largest tabulated collection in the personal experience of One surgeon, is the list by the writer, of one thousand cases of compound fractures, with a mortality from Septo- pyaemia of one-seventh of one per cent. The best pub- AOHIETVEMENT'S OF AMERICAN SURGERY 213 lished reports from Europe, are from Billroth, whose mortality in compound fractures was three per cent. No better idea of the onward march and steady progress of American surgery can be formed, than by a consider- ation of the fact that, before the days of antiseptic Sur- gery, the death-rate was as high as sixty-eight per cent. in the major fractures, and that now the mortality has been practically reduced to zero. The ingenuity of American surgeons cannot be better illustrated, than by demonstrating to this audience a splint made by Dr. Cotting, of Roxbury, Mass. Dr. Cotting is a retired surgeon, who is now over eighty years old, but who has kindly furnished me some inter- esting facts in regard to the manufacture of, and use of, splints for fractures. Dr. Cotting amused himself, one day recently, in making this splint, such as was in vogue years ago in New England. This splint is a model of Yankee ingenuity, and one perfectly adapted to the treatment of fractures. Besides the perfect adaptability of the splint, its essential characteristic is, that it is simple, and can be made by anyone, at any time, and in any place. The perfect simplicity becomes apparent, when it is considered that this splint itself was made from a fragment of a piece of a millinery box, the iron from a tub-hoop, the rivets from ordinary tacks, the cloth and wadding from remnants in the house, and the paste from flour and water. All of these requisites can be found in any city house, or in a log-cabin in a remote Wilderness. The application of the iron was effected, by using as an anvil the head of a hatchet, struck into a block, and a common house claw-hammer to rivet the tacks, the holes for which were driven by a sharp- pointed nail. Dr. Ira Allen, of Roxbury, Mass., about half a century ago, suggested the use of iron in the con- Struction of splints, and Dr. Cotting, at that time, made Splints such as the one now on exhibition. This splint has lightness, strength, and Simplicity, and possesses at the same time every advantage that can be possibly 214 NEW YORK STATE MEDICAL ASSOCIATION. claimed for any splint. This splint affords comfort to the patient, and is capable of adjustment to any fracture or to any diseased joint. The true germ of every useful splint of the present day, is found contained in this model. - In 1878, Pilcher first pointed out the correct pathology and treatment of fractures of lower end of radius. Before dismissing the subject of fractures, the work of Frank H. Hamilton must not be overlooked, since he did more to systematise and to perfect the treatment of fractures in general, than any other American Surgeon. The work of Stimson likewise deserves the highest tribute of respect. The saw devised by Shrady for per- forming a subcutaneous section of the bone, is an in- strument worthy of the highest commendation. Exci- sion of the superior maxillary bone with the exception of the orbital plate, was first performed by Jameson, in 1820. The complete excision of the superior maxilla was first performed in this city by David L. Rodgers, in 1824. Excision of the inferior maxilla was first partially and successfully made, “without known precedent, or pro- fessional counsel or aid,” by Deadrich, of Tennessee, in 1810. Jameson exsected nearly the entire inferior max- illa in 1820, Mott exsected one-half of the jaw in 1821, and Ackley in 1850; and Carnochan, in 1851, excised the entire bone. Excision of the os hyoides was per- formed for the first time, by Dr. John C. Warren, in 1803. Excision of the wedge-shaped piece of bone from the tibia and fibula, with osteoclasis of the bones, to cor- rect a deformity by an osteotomy, was performed by Dr. John C. Warren, in 1820. In 1835, Barton devised an operation which is still practiced for the relief of angular anchylosis of the knee. The entire clavicle was excised successfully for necrosis for the first time in 1813, by Mc- Creary of Kentucky. The entire clavicle was again ex- cised successfully for the first time, formalignant disease, by Mott, in 1828. The entire scapula, three-fourths of the clavicle, and the arm were excised for the first time, and AOHIEVEMENT'S OF AMERICAW SURGERY. 215 also successfully, by Dixi Crosby, in 1836. This same operation was repeated by Twitchell in 1838, by Mac- Clellan in 1838, and by Mussey in 1845; and since then to the present time, the operation has been performed about twenty-five times throughout the world. The en- tire scapula and the clavicle were removed successfully, six years after an amputation at the shoulder-joint, by Mussey, in 1837. Two-thirds of the ulna were excised successfully by Butt, of Virginia, in 1825, and the olec- ranon by Buck, in 1842, while the entire ulna was excised by Carnochan, in 1853. The same operator ex- cised the entire radius in 1854. Both radius and ulna were excised by Compton, of New Orleans, in 1853. Excision of the coccyx was first performed by Nott, in 1832, for the relief of severe and persistent neuralgia. Excision of a portion of the rib by the trephine, for affording drainage in empyema, was first performed by Stone in 1862, and excision of a part of one or more ribs for the same purpose, was first performed by Walter, of Pittsburgh, in 1857. Removal of a disk of bone for drainage in non-traumatic, diffuse, acute, suppurative Osteomyelitis, was done in 1798 by Nathan R. Smith, Who anticipated Brodie in the performance of this opera- tion. Brodie's operation had reference to circumscribed abscess of bone. Besides these excisions for necrosis, suppuration, and malignant disease, much credit is due to American sur- gery for the part it has played in subperiosteal surgery. One of the most remarkable specimens is the reproduc- tion of the inferior maxilla by Wood, in 1856. This jaw Was exhibited by Dr. Wiggin at the Berlin Congress of Surgeons, in 1877, and Langenbeck, the authority on Subperiosteal surgery, said, “that he did not believe a Corresponding preparation really existed anywhere,” and remarked, that “there was not another such specimen in the whole of Europe.” This was indeed a fitting tribute, from one of Europe's greatest surgeons, to the genius of one of America's greatest operators. Wood 216 JNETW YORK STATE MEDICAL ASSOCIATION. has also succeeded in reproducing many other bones in the body by the application of the same principles of subperiosteal surgery. These Specimens form a unique group, and are carefully preserved in the museum which bears his name. Thus it is evident, if the first success- ful excision of the superior and inferior maxillae, the hyoid bone, the entire clavicle, the entire scapula, the ulna and radius, the coccyx and ribs; also trephining for relief of osteomyelitis and the most perfect specimens of reproduced bone, be subtracted from the sum total of operative surgery upon the bones, there is little left which is not the offspring of American surgery. In the surgery of the joints, American Surgeons have since accomplished brilliant results. In the management of dislocations, they have contributed much to the sum total of our knowledge. Physick was the first to per- form venesection to cause muscular relaxation, in Order to reduce a dislocation. This was a most valuable means, to which resort was made prior to the introduc- tion of anaesthetics. McKenzie and Smith, in 1805, reduced a dislocation of the shoulder of six months’ standing, by the employ- ment of venesection. This patient had been to England, and all attempts at reduction had failed, and upon his return to Baltimore, the reduction was effected by re- laxing the muscular system by blood-letting ad dele- quium animi. This plan is now abandoned since the introduction of anaesthetics. John C. Warren excised the head of the humerus, to restore the usefulness of it after an unreduced disloca- tion of the shoulder-joint. Wood practiced tenotomy with great success, in order to reduce difficult dislocations of the major joints, and also for dislocation of the peroneal tendon. Before dismissing the subject of tenotomy, it is stated in Cooper’s “Dictionary of Surgery,” that Gibson, in 1842, divided the straight muscles of the eye for the relief of strabismus, several years before Dieffenbach, of Berlin. ACHIEVEMENT'S OF AMERICAN SURGERY 217 In 1826, Dixi Crosby demonstrated the causes of failure to reduce the dislocation of the thumb, and showed that forced extension and pressure upon the base of the dis- located bone would effect a reduction. In 1855, W. W. Reid published his method of reduc- ing dislocation of the hip by manipulation, to which must be added the contributions of Smith, Gunn, Bige- low, and Stimson. In 1856, Dugas pointed out a most important diagnos- tic sign, of great value in dislocation of the shoulder. Bigelow pointed out two obstacles to reduction in hip- joint dislocation. Sayre is the American surgeon who is entitled to the honor of having established Orthopaedic Surgery as a separate school of Surgery in this country. In the inflammatory affections of joints, American surgeons have advanced the principles which to-day are considered sound, and which are universally adopted. Physick insisted upon absolute rest of an inflamed limb. Harris, in 1825, first insisted upon fixation and extension in the management of inflamed joints. Later on the principle of fixation and extension was modified, so as to permit the patient to be up and about ; Subsequently this principle was carried out in the ankle and knee joints by an instrument devised by Sayre, and in the hip, by an instrument first invented by Davis, of this city, previous to 1860, and since modified and improved by Sayre. There are other splints employed which are most use- ful, notably those of Taylor, Shaffer, Ridlon, A. M. Phelps, Gibney, and others; while the work of Whit- man, Willard, Judson, Vance, Reginald, Sayre, and Townsend, in this department of surgery, merits the highest consideration. The invention of the plaster-of- Paris jacket by Sayre, for the treatment of Pott's dis- ease, in 1874, is one of the most important surgical discoveries of the century. This same apparatus he devised for the treatment of lateral curvature. These 218 NEW YORK STATE MEDIOAL ASSOCIATION. cases of Pott's disease, which hitherto were consigned to a distressing death, are now permanently relieved of their sufferings, and are in many cases entirely cured. - Excision of the hip-joint was performed as a syste- matic operation, and successfully, for the first time in this country, by Sayre, in 1854. To this same surgeon is due the credit, of suggesting and carrying into execution, the principle of free drainage in cases of empyema of joints. In hydrops articuli, Martin, of Boston, in 1853, Sug- gested equable uniform compression by means of an elastic bandage, and Sayre has applied the same prin- ciple by using compressed sponges. Martin, in 1877, also employed the elastic bandage for the cure of chronic ulcers of the leg. In 1826, Barton divided with a saw the great trochan- ter and the neck of the thigh, to relieve anchylosis of the hip-joint; in 1830, Rodgers removed a disk of bone; and in 1862, Sayre perfected the operation and introduced a new principle, by removing a plano-convex wedge of bone between the two trochanters, and making rotund the end of the lower fragment, in order to form a new and artificial joint. In 1835, Barton removed a cuneiform wedge just above the condyle, fractured the bone, and made the limb straight, to relieve angular anchylosis of the knee-joint. This operation is practically the Osteotomy of the pres- ent time. In 1840, Carnochan first operated for the relief of an- chylosis of the lower jaw, by subcutaneously dividing the masseter muscle. In forcing open the mouth after tenot- omy of the muscle, he accidentally fractured the bone, thus producing a false joint until the fracture united. Carnochan conceived then the idea of excising a wedge- shaped piece from the jaw, and establishing a false joint. For the relief of this distressing condition, in 1873, Gross excised the condyle and a portion of the neck of the bone, and in 1875, Mears excised the coronoid and condyloid processes, together with the upper half of the ramus. ACHIEVEMENT'S OF AMERIOA.W SURGERY. 219 Wood, in 1876, cured a patient with fracture of the cervical vertebra, associated with paraplegia and brachial paralysis, by the use of the plaster-of-Paris jacket. The patient, though completely paralysed, made an excel- lent recovery, and was able to resume his work as a carpenter. 2d. Surgery of the Vascular System.–In the surgery of the vascular system American operators have made most valuable contributions. The innominate artery was ligated for the first time in the history of surgery, by Valentine Mott, of this city, on May 11, 1818. The operation was performed for the cure of aneurysm, and the patient died. The operation was essayed for the second time by Hall, of Baltimore, in 1830, and again by Cooper, of San Francisco, in 1859. Both of these cases terminated fatally. The artery was finally tied successfully, for the first time, by Smyth, of New Orleans, on May 9, 1864. This last operator tied also the vertebral in the same patient, for the first time. Thus, it is evident that the ligature of the innominate artery was first performed in this country, and it was first ligated successfully in America. And the artery has never been ligated anywhere else successfully but in this country. Mott tied one hundred and thirty-eight large arteries for the relief of aneurysm ; and no other surgeon in the World has ever ligated so many vessels. The primitive carotid artery was ligated for the first time successfully, for primary haemorrhage, by Cogs- Well, of Hartford, Conn., on November 4,1803. Abernethy is credited with tying the primitive carotid first in 1798; but his case died. The first successful case, therefore, of ligature of the primitive carotid for primary haemor- rhage, was in America, and Cogswell had no knowledge of Abernethy’s unsuccessful attempt. Again, the primi- tive carotid was first tied successfully for secondary haemorrhage by Amos Twitchell, of Keene, N. H., in 1807, eight months prior to Sir Astley Cooper's famous 220 NEW YORK STATE MEDICAL ASSOCIATION. case, which was supposed until lately to be the first upon record. The primitive carotid was first tied in its con- tinuity successfully, for the cure of aneurysm, by J. Wright Post, on January 9, 1813. This same surgeon again repeated the operation successfully on November 28, 1816. - The two primitive carotids were first tied in their continuity successfully, within a month’s interval, by Macgill, of Maryland, in 1823. Mott tied both carotids simultaneously in 1833, for malignant disease of the par- otid gland. In 1823, Davidge first tied the carotid artery for fungous tumor of the antrum. The primitive and internal carotids were first tied simultaneously by Gurdon Buck, of New York City, in 1857, and again by Briggs, of Nashville, in 1871. The internal carotid was tied successfully, above and below, for secondary haem- orrhage, by Sands, in 1874. Carnochan tied both caro- tids for the first time, for elephantiasis arabum of the neck and face, in 1867. The subclavian artery in its third portion was first tied successfully, for the cure of aneurysm, by J. Wright Post, of New York City, in September, 1817. The sub- clavian artery in its first position was ligated for the first time by J. Kearney Rodgers, in 1845. The case died, and the vessel was not tied successfully until 1892, when it was done by Halsted, of Baltimore. The operation was for the cure of aneurysm, and the sac was dissected out by the removal of the clavicle. This is the only case in which the ligation of the subclavian on its tracheal side has ever been successful, although unsuccessful attempts have been made in other countries. - The primitive iliac artery was first tied in America by Gibson, of Baltimore, in 1812. The ligation was for the arrest of haemorrhage following a gun-shot wound. The patient died after the thirteenth day. Valentine Mott tied the artery successfully for the cure of aneurysm, On March 15, 1827. In 1880, Sands first tied the primitive iliac for aneurysm of the left external iliac, by first ACHIEVEMENTS OF AMERICAN SURGERY. 221 performing a laparotomy, and securing the vessel by this procedure. The internal iliac was first successfully tied for the cure of an aneurysm, by Stevens, in 1812, and again suc- cessfully by Mott, in 1827, and by White, in 1847. The two internal iliacs were first tied simultaneously for the cure of double gluteal aneurysm, by the writer, in 1886, upon a patient of Carpenter, of Boonton. In this case, a laparotomy was first performed. The patient died of uraemia. The same operator has since tied suc- cessfully the internal iliac for the cure of gluteal aneu- rysm, for the first time by laparotomy, as a first step in the operation ; and also the internal pudic branch of the internal iliac artery for the first time successfully out- side the pelvis, for the arrest of secondary haemorrhage in the perinaeum. The external iliac was tied successfully in 1811, by Dorsey, and again successfully by Post, in 1814. In 1794–95, Post placed a ligature around the femoral artery for the cure of aneurysm, and the patient was cured. Onderdonk, in 1813, tied the femoral artery suc- cessfully for acute phlegmonous inflammation of the knee-joint, and Rodgers did the same operation with suc- cess in 1824. Carnochan, in 1851, tied the femoral artery for the first time for the cure of elephantiasis arabum, thereby inaugurating a new principle of treatment. In May, 1821, Jameson ligated the externaliliac artery, and Davidge, who settled in Baltimore in 1796, shortly after this, first ligated the gluteal artery. Thus, it has been shown that the ligation of the innom- inate, the subclavian both in the first and third portion, the primitive carotid, both primitive carotids simultane- Qusly, primitive and the internal carotids, the primitive iliac and the internal iliac, have all been tied for the first time successfully in America; and further, that the primitive carotid was first successfully tied for primary haemorrhage, and also for Secondary haemorrhage, and the primitive and internal carotids simultaneously tied 222 NEW YORK STATE MEDICAL ASSOCIATION. for traumatic aneurysm, and the internal carotid for secondary haemorrhage, and both internal iliacs simul- taneously, in this country. In the surgery of the arteries there seems little left to the credit of any other country. In addition to the various ligations already mentioned for the cure of aneurysm, a variety of compression, known as digital pressure, was carried into practice by Jonathan Knight, of New Haven, in 1848. There are many modi- fications of digital pressure. Wood utilised the bag of shot, which was suspended over the patient, and by this means, the pressure was effected by it, instead of by the finger. In 1874, Stone, of New Orleans, first cured a traumatic aneurysm of the Second portion of the subcla- vian artery, by digital pressure upon the third portion of the vessel. Martin, in 1877, suggested the use of the elastic ban- dage in the treatment of varicose veins, and Dr. Charles Phelps the method by the multiple ligature of the veins from the ankle to the Saphenous opening. He applies some thirty ligatures to the limb, and the results of his operation have been most satisfactory. There has been much diversity of opinion as to whom the credit belongs for the introduction of the Esmarch bandage. In the public clinics of the Jefferson Medical College, at the time of an amputation, the elder Pancoast and Gross rendered the limb bloodless by elevating it, and by the application of a roller bandage. This was done before a tourniquet was applied. The value of this procedure was not published, and to Esmarch is due the credit of having adopted the principle, with the modifi- cation of the elastic bandage, and having published it abroad for the benefit of the profession. In 1874, Woodbury, of Philadelphia, suggested digital pressure of the common iliac, with the hand introduced through the sphincter; and Wyeth has devised a method of controlling haemorrhage during amputation of the hip- joint, which deserves mention. ACHIEVEMENTS OF AMERICAN SURGERY. 223 3d. Surgery of the Great Cavities of the Body—Sur- gery of the Cranial Cavity.—In cerebral surgery, Ameri- can surgeons have accomplished excellent work; but this is not the place or the time to review the entire field of brain surgery. Within a few years great progress has been made in this department, but that part which has reference to the work of American surgeons only concerns us this evening. Trephining for the relief of epilepsy was performed by Dudley, of Kentucky, prior to 1828, with sixty per cent. of permanent cures. Dr. Mason Warren trephined a child for epilepsy in June, 1849, for the relief of acci- dental idiotism. A case of cerebral abscess was opened by Detmold in 1855, and pus evacuated from the lateral ventricle. The lateral ventricle itself was opened by Dennis, in 1889, for the purpose of removing a blood-clot in a case of traumatic haemorrhage. There was no wound of the soft parts, or fracture of the bone, to indicate the place to trephine, and the diagnosis of cortical haemor- rhage was made before the operation. This is a unique case in the annals of surgery. The brain substance itself has been explored by Fluh- rer, who was the first to locate a pistol-ball within the brain, by the use of his special probe. He extracted the bullet by a counter opening made with a trephine. He had also located by means of the probe, and extracted, a bullet, which was embedded in the substance of the brain, two and three-quarter inches. This operation was followed by complete recovery. In the removal of cerebral tumors, American surgeons Cannot establish any claim for priority, and but little for originality; but they can at least establish claim for hav- ing had many cases of this nature, since nearly one-third of all the cases operated upon have been by American Surgeons. The work of Weir, Keen, Roswell Park, Mills, Hearn, McBurney, Birdsall, Bullard and Bradford, Mar- koe, Curtis, Charles Phelps, Deaven, Bryant, Lloyd, and Hun deserve the highest commendation. American sur- 224 NEW YORK STATE MEDICAL ASSOCIATION. gery would be ungracious not to acknowledge the work of Starr, Mills, Seguin, Putnam, Spitzka, Gray, McDon- ald, Sachs, Dana, Janeway, and Clymer, since these neurologists have prepared the way for the work of the surgeons. Trephining for traumatic meningeal haemor- rhage, for pachymeningitis interna haemorrhagica, and other like conditions, have been employed by surgeons, who have reported the result of their operations. In all probability, the most important medical event which has ever happened in this country, or in the world, was the conception, development, and birth of ovariot- omy. To Dr. Ephraim McDowell, of Danville, Ky., be- longs this great honor. In 1809, he was the first to per- form this unique and Original operation, which has made his name immortal. The far-reaching influences which have proceeded from this step are incalculable. Dr. McDowell is finally recognised as the originator of not only one of the greatest operations in surgery, but also as the author of an operation, the influence of which has made it possible to develop the present wide field of abdominal surgery. McDowell's work will live in the memory of thousands in this land, and will be honored, the world over, as long as time endures. In 1821, Dr. Nathan Smith performed ovariotomy in Connecticut, and without the knowledge that it had been performed by McDowell; Smith dropped the pedicle into the abdominal cavity, and thus made a great advance in McDowell's operation. In 1823, Alban G. Smith also performed an ovariotomy in Kentucky, and David L. Rodgers, in New York, in 1829. All these cases of ovariotomy were successful. It was seven years after this last American operation, before ovariotomy was first performed in England, and nearly fifteen years be- fore ovariotomy was first performed in France. In 1870, T. Gaillard Thomas first devised and performed success- fully a vaginal ovariotomy. In 1872, Dr. Davis, of Pennsylvania, performed successfully the same opera- tion; he was followed in 1873 by Gilmore, of Alabama, and in 1874, by Battey, of Georgia, and later by Sims. ACEHIEVEMENTS OF AMERICAN SURGERY. 225 In 1872, Battey performed his first oëphorectomy, “with a view to establish at once the change of life for the effectual remedy of certain otherwise incurable mala- dies.” This is an operation also of purely American ori- gin, and has contributed much to the relief of human suffering. - r It has been urged, that while to an American surgeon the credit is honestly due for the first performance of an ovariotomy, other nations have perfected the operation, and that more credit is due to-day to other nations for the best results. Let us see how this statement accords with facts. In 1857, the question of ovariotomy was brought up for discussion at the French Academy of Medicine, and only one surgeon considered the operation as sometimes justifiable. Up to that time there had been in America, ninety-seven ovariotomies, with thirty-four per cent. mortality; in Great Britain, one hundred and twenty-three operations, with forty-three per cent. mor- tality; while in Germany there had been forty-seven Operations, with seventy-seven per cent. mortality. Amer- ican surgeons, therefore, not only obtained the best re- Sults up to that date, but no American surgeon to-day will concede that our results are inferior to those ob- tained by surgeons in any other country at the present time. Among American surgeons who are now contribut- ing to the success of ovariotomy, may be mentioned, Thomas, Lusk, Polk, Wylie, Mundé, Goddell, Kelly, Homans, Price, Janvrin, Leidy, and Dudley. Few men can realise the influence of McDowell’s first OVariotomy upon the whole field of abdominal surgery. It is indeed a sublime thought to consider, that a man Was found with the courage of his convictions to do what no man had ever done, and to operate within the noise of the infuriated mob beneath his windows. This mob Would have lynched him if Mrs. Crawford had died. Having escaped the angry mob, he was pointed out as a murderer by his fellow-colleagues, and was condemned by the highest scientific authorities in Europe. In Amer- 15 226 NEW YORK STATE MEDICAL ASSOCIATION. ica, therefore, under such circumstances and under such conditions, the birth of the greatest operation in surgery occurred—an operation destined to save in the future millions of human lives. The disapproval of this great operation of McDowell’s, by the press, by the profession, and by the laity was pro- nounced. The Medico-Chirurgical Review, speaking of McDowell’s achievement, says: “A back settlement of America, Kentucky, has beaten the Mother Country, nay, Europe itself, with all the boasted surgeons thereof, in the fearful and formidable Operation of gastrotomy with the extraction of diseased ovaries.” All this vitupera- tion was hurled at McDowell, but time, as the great arbi- ter, has demonstrated that what was said in sarcasm, has become a transcendent and mighty truth. The noble character and the true grandeur of McDowell’s nature, and his high and lofty ambitions, are illustrated by the fact that he had performed three successful ovariot- omies, operations never before undertaken by man, with- out heralding the victories as triumphs of his personal ambition. In the early days of ovariotomy, McDowell and Na- than Smith, the Atlees, Dunlap, Peaslee, Kimball, Sims, and Thomas, have established and brought to the front an operation, against which the most bitter and scathing invectives have been aimed. These great men, who have placed this operation upon a firm basis, deserve the grat- itude of a nation, and of the world, since they have thrown a flood of light upon this dark region of surgery, which is now illuminated by the work of recent opera- tors, whose successes are simply miraculous. The operation of hysterectomy is one that was per- formed very early in the history of this country, since it has been ascertained that in 1813, Joseph Glover, of South Carolina, removed the entire uterus, and the patient made a complete recovery. This operation OC- curred just four years subsequent to McDowell’s first ovariotomy. Dr. J. Briggs also repeated the operation ACHIEVEMENTS OF AMERICAN SURGERY. 227 in 1830, and Dr. J. M. Briggs is said to have performed the same operation previous to 1830, the exact date of which is unknown. Polk, of this city, has performed hysterectomy with the largest percentage of recoveries. In 1759, John Bard operated for extra-uterine preg- nancy, and in 1791, the operation of gastrotomy for the same condition was successfully carried into execution by William Baynham, and again successfully in 1799, by the same surgeon. Since then, the operation has been performed frequently. In 1816 John King, of South Carolina, removed a living child, in the case of an extra- uterine pregnancy, by opening into the pelvic cavity by the side of the vagina, and extracting the child with forceps. In 1824, Jameson first incised the cervix uteri, and in 1870, T. Gaillard Thomas, and in 1876, Skene, of Brook- lyn, both successfully performed gastro-elytrotomy. In 1862, Emmet described a new operation in gynaeco- logical surgery for the relief of lacerated cervix. This Operation has contributed much to the relief of suffering in those cases which hitherto baffled medical skill. He also devised an operation for prolapsus of the uterus in 1869, one for displacement of this organ in 1874, one for lacerated perinaeum and rectocele in 1882, and one for the purpose of exploring the bladder on removing ure- thral caruncle by a button-slit in the urethra. To our countryman, J. Marion Sims, is due the great honor of perfecting, in 1852, the operation for the cure of vesico-vaginal fistula, and while the operation itself Was not first executed in this country, it was so im- proved and perfected here, that to-day, the operation of Sims is the one universally practiced. Nathan Bozeman has also devised an operation for the relief of this condi- tion, by operating in the knee-chest position, with instru- ments especially devised by himself. This operation has Prevented much suffering and distress, which before the Perfected operation of Sims, was considered as practically *nourable. The same surgeon also devised, in 1856, the 99eration for prolapse of the uterus, and in 1857 for 228 JWEW YORK STATE MEDICAL ASSOCIATION, the relief of vaginismus, and perfected the technique of amputation of the cervix in 1859. t In closing this brief sketch of American gynaecological Surgery, it is obvious that it was an American Surgeon to whom the honor of first performing ovariotomy is due. Sir Spencer Wells is said to have added twenty thousand years to the lives of British women, and by the same process of reasoning, Ephraim McDowell, the Kentucky frontier surgeon, has already added hundreds of thou- sands of years to the lives of women throughout the world. Our country has achieved its most brilliant triumphs in this department of Surgery, and to American surgeons belong the honor of not only first performing nearly every important surgical gynaecological Operation, but also of perfecting the technique of the less important Surgical procedures. A most worthy compliment to American gynaecological surgery is the fact, that one of Great Britain’s most famous ovariotomists sent his son to Our Shores to study and to perfect himself in gynaeco- logical Surgery. The Operation of Caesarean section has met with un- usual success in this country. Lusk has operated five times, with three successful results; the fourth case died of intestinal obstruction, consequent upon a pelvic ab- scess, due to Pott's disease; and the fifth died also of Pott's disease. Kelly has performed the operation five times, with four successful results. Thomas has oper- ated with success; also Jewett, of Brooklyn; Price and Noble, of Philadelphia; Garrigues, Coe, and Grandin, of New York. Gibson performed Caesarean section twice upon the same patient; once in 1835, and again in 1837. The patient recovered from these operations, and lived to the age of seventy-five. Kelly devised a new opera- tion for the relief of retro-displacement of the uterus. The operation was modified by Krug, in 1890, and also by Dudley, of New York. E. C. Dudley, of Chicago, has de- vised an operation for antero-displacements, and the same Operator has also improved the Alexander operation. ACHIETVEMENT'S OF AMERICAN SURGERY. 229 Newman devised his operation for shortening the round ligaments in September, 1888. Outerbridge, in 1889, devised a speculum for dilatation of the cervix in cases of Stenosis, when sterility exists. Laparotomy was performed by Dr. Wilson, in 1831, for the relief of an intussusception. The patient was a negro slave, and had suffered from intestinal obstruction for seventeen days. The abdomen was opened, and the intussusception found; it was then drawn out and re- leased, and the patient made a complete recovery. In 1792, Physick devised an operation for the cure of artificial pouches in the alimentary canal. In 1809, Physick was the first to ligate the eperon, where an artificial opening had been made in the intestine on account of pathological changes. In 1847, Gross urged the excision of a section of the intestine, with suturing of the divided ends, with a view to establish the continuity of the canal, but the patient refused; in 1863, Kinloch, of South Carolina, accomplished this result. In 1834, Luzenberg laid open a strangulated hernia, found it gangrenous, excised the mortified section of the intestine, stitched the serous surfaces, and the patient fully recovered. This same surgeon suggested, in 1832, exclusion of light to prevent pitting in small-pox. The operation of laparotomy for the treatment of pene- trating gun-shot and stab-wounds of the peritonaeal cav- ity, was the work of American surgery. Gross, in 1843, and Sims, just before his death, suggested this method, but these gentlemen never practiced it. It remained for Dr. W. T. Bull to make the practical application of the method, and to him is due the credit of this great ad- Vance in Surgery. It is a source of national pride, that laparotomy in penetrating wounds and visceral injuries of the abdomen, was conceived, developed, and perfected in America. The wide-spreading influence of this oper- ation is felt in abdominal surgery, and much of the present advance is the result of Bull's surgery. The Work of Senn and Abbe in intestinal anastomosis also deserves the highest praise. 230 NETW YORK STATE MEDICAL ASSOCIATION. The operation for the relief of acute appendicitis is clearly traced to the work of American surgeons. In 1843, Willard Parker, and later Gurdon Buck, did much to explain the nature of these iliac inflammations; and Sands cleared the way for the perfected operation of McBurney, which aims to prevent these dangerous peri- tonaeal inflammations, and to prepare the wound for aseptic healing. Sands first operated with success, after perforation had taken place, and general peritonitis was present. To McBurney is due great credit for the per- fection of this operation, which is now recognised throughout the world as the best, safest, and most scien- tific way of managing these varieties of Suppuration, hitherto so fatal. The operation of removing the appendix vermiformis during the quiescent period, between relapsing attacks, was suggested by Treves, of London, although the ap- pendix was successfully removed in this country by the writer, in 1887. In this case, the appendix was diseased, Owing to adhesions to an ovarian tumor. The first and only successful case of laparotomy for the relief of perforation of the intestine during the prog- ress of typhoid fever, was performed in this country, and to Dr. Weller VanHook, of Chicago, is due the credit of having first established an operation for the relief of these cases, which hitherto were fatal. Still another important discovery must not be over- looked, and that is Senn’s insufflation of hydrogen as an infallible test in the diagnosis of visceral injury of the gastro-intestinal canal, in penetrating wounds of the ab- domen. Senn has also made other valuable contributions to abdominal surgery, and his work entitles him to the gratitude of the profession. - Laparotomy for the relief of purulent peritonitis, was performed by Mears, of Philadelphia, in 1875. This case was among the first, if not the first, where the peri- tonaeal cavity was opened for the express purpose of washing it out, and draining it like any abscess cavity. ACHIEVEMENTS OF AMERICAN SURGERY. 231 The work of Abbe, Hartley, Curtis, McCosh, Briddon, Lange, Stimson, Morton, and Vanderveer, deserves great commendation. In the surgery of the liver, American surgeons have distinguished themselves. In 1867, Dr. Bobbs, of In- dianapolis, was the first surgeon to perform the mod- ern operation of cholecystotomy, which he did success- fully, and removed fifty biliary calculi from an incision into the gall-bladder. He was followed, in 1868, by Dr. J. Marion Sims, who removed sixty stones from the gall- bladder. To Tait, however, belongs the great credit of perfecting the technique of this operation, and he stands, to-day, pre-eminently the authority upon hepatic surgery. Excision of biliary calculi by incision into the umbilical vein, was performed by Dr. John C. Warren, of Boston, in the early part of the present century. In the surgery of the spleen, American surgeons have a record of which they need not be ashamed. In review- ing the literature of splenectomy, the case of Zaccarelli, in 1549, may be excluded, Sir Spencer Wells says, as apocryphal. The next authentic case is one by Quitten- baum, of Rostock. This splenectomy was performed in 1826, and the patient died. But in 1801, a quarter of a century previous to this case, Dr. Joseph Glover, of Charleston, S. C., removed nearly the entire spleen and Some Omentum, and ligated a branch of the splenic artery. This was not, however, an extirpation of the Spleen for any pathological condition. The spleen was also removed for gun-shot wound, by Dr. Alston, of Texas, about 1863, and the patient recovered. What little has been done in the surgery of the pancreas has been done by American surgeons. The literature of the subject is contained in an elaborate brochure by Senn. There have been only four cases of cysts of the pancreas diagnosticated, and these were operated upon success- fully by Senn, Tremaine, Bull, and Bozeman. 4th. Surgery of the Genito- Urimary System.–In the department of genito-urinary surgery, a great advance 232 MEW YORK STATE MEDICAL ASSOCIATION. has been made by the invention of instruments to facili- tate and improve the technique. * The cystoscope is an American instrument, having been invented by Dr. John D. Fisher, of Boston, in 1824, while Civiale and Heurteloup did not invent their instruments until 1827. The cystoscope of to-day is one which has been evolved from the general principle of Fisher’s endoscope. Dr. W. K. Otis has perfected the urethro- scope by the addition of a new electric lamp. Klotz has also devised a cystoscope, which is in use at the present time. Dr. F. T. Brown has devised a most useful urethral speculum for the purpose of making topical applications to the canal. The Gross urethrotome, Powell’s urethral dilator, the dilating urethrotome, and the urethrotometer of Otis, are instruments deserving of mention. The work of Bumstead and of Van Buren, in this department of surgery, has already a world-wide reputation. - The operation of nephrectomy for the relief of malig- nant disease of the kidney, is of American origin, since it was first performed by Wolcott, of Milwaukee, in 1860. British surgeons give the credit of this operation to Simon, of Heidelberg ; but he did not perform his opera- tion until 1869, or nine years after Wolcott’s operation. Nephrectomy was first performed in America for gun- shot wound of the kidney, by Keen, in 1887, and again two months later, for the same condition, by Willard, and still again for the same cause, by Price, successfully, in 1888. The first successful operation for the relief of extro- version of the bladder, was performed in this city by Dr. A. L. Carroll, on April 13, 1858. Pancoast performed this operation successfully the same year, and Ayers, in 1859. All of these cases ante-date the British success of Woods and Holmes, although there are two operative failures reported by Cook and Lloyd, in London, in 1851. Lapar- otomy for rupture of the bladder was successfully per- formed by Walters, of Pittsburgh, in 1862; but to Sir William MacCormac is justly due the credit of establish- ing this operation. . ACHIEVEMENTS OF AMERICAN SURGERY 233 In the plastic surgery of the urethra, another brilliant triumph has been made by American surgeons. In 1892, Dr. Samuel Alexander succeeded, for the first time in the history of genito-urinary surgery, in a case of complete epispadias in the female, in making a new urethra, the retentive powers of which were perfect. There have been twelve cases, in all, of complete epispadias, in none of which heretofore has the urine been completely under the control of the patient. In 1795, Physick did an internal urethrotomy by a concealed lancet, and Alexander Stevens, in 1817, was the first surgeon in this country to perform external perinaeal urethrotomy. He revived an operation which had fallen into desuetude, at the close of the last century, because of the great mortality which attended it. Prior to 1840, the operation was performed in this country by several surgeons; notably, in 1820, by Jameson ; in 1823, by Rodgers; in 1829, by Warren ; and later, by several sur- geons connected with the New York Hospital, among whom may be mentioned Hoffman, Post, and Watson; and also by Alden March, of Albany, and Wood, of New York City. Without doubt the operation has reached its present state of perfection through the labors of Gouley, who suggested the whalebone guide, the tun- neled catheter staff, and the beaked bistoury. The oper- ation of Fluhrer, with his instruments, which are marvels of mechanical skill and precision, has still further im- proved the technique of external perinaeal urethrotomy. The operation of supra-pubic prostatectomy was first performed in this country by Belfield, in October, 1886. This operation has been greatly improved upon by the use of Gouley’s prostatectome, which facilitates the re- moval of the gland. In lithotomy, American surgeons have achieved bril- liant results. McDowell did thirty-two lithotomies in Succession without a death. Dudley performed one hundred consecutive operations without a fatal case. In 1846, Willard Parker removed a calculus from the blad- 234 METW YORK STATE MEDICAL ASSOCIATION. der by producing a recto-vesical fistula, and subsequently performed this operation for the cure of chronic cystitis. In 1861, Dr. Bozeman did this same operation to relieve a chronic cystitis in the female. Physick did his first Operation for stone in 1797, and in doing it, wounded the internal pudic artery. This accident led to the inven- tion of his needle for carrying a ligature around deep- Seated vessels. In 1836, this same operator removed over One thousand calculi from the bladder of Chief Justice Marshall. These brilliant results in lithotomy are most remarkable, when it is considered that there was a time, in the medical history of this country, when a patient actually made the pilgrimage across the Ocean, in order to secure the services of a surgeon to perform lithotomy. In lithrotrity, American surgeons have obtained re- sults which compare favorably with the work of lithot- rotists of other countries. Keyes has made Some great improvements in litholapaxy, thereby reducing the mor- tality of the operation. Among these may be mentioned the evacuating tube, the alteration in the mechanism, and other improvements in the technique of the operation. To Henry J. Bigelow, of Boston, is due the credit of having made important changes in the technique of lith- otrity. In 1878, Bigelow pointed out the important fact that a calculus could be crushed, and the debris removed, at a single operation. This was a great step forward, and litholapaxy of to-day is an operation of American origin, since Bigelow devised a lithotrite for crushing the stone and an evacuator for washing out the bladder. Bigelow’s operation has been performed by Keegan fifty-nine times in children, with one death ; and by Freyer, forty-nine times, without a death. This, the American operation of litholapaxy, has certainly won for itself a fixed place in the annals of surgery. 5th. Miscellaneous Operations.—There are many mis- cellaneous operations in surgery which are purely of American origin, or they have been so improved in tech- nique as to be properly claimed as American. The scar- ACHIEVEMENTS OF AMERICAN SURGERY. 235 ification of the infiltrated mucous membrane in Oedema glottidis, as suggested by Buck, and the removal of polypi from the larynx by the same surgeon, who was the first to do this in America, and the second in the world, are worthy of record. Frank Hamilton, in 1854, was the first to transplant skin for the repair of ulcers. This operation he termed anaplasty. In October, 1842, Sayre made a free incision into the chest in a case of empyema, and the patient made a good recovery. Forty years ago, in a case of empyema, Oc- curring in a tuberculous patient from the rupture of an abscess into the pleura, Sayre raised the query—would we not be justified in tapping as soon as the effusion is discovered 3 In 1850, Dr. Henry I. Bowditch suggested and prac- ticed paracentesis thoracis. Dr. Morrill Wyman, un- aware of Dr. Bowditch’s operation, performed the same Operation. For a long time in this country, as well as in Europe, paracentesis thoracis was condemned ; but at last the operation has advanced to the stage of full acceptance by all surgeons. It is almost impossible to estimate the number of lives saved by this operation, but it is very great, and this operation forms an enduring monument to the fame of these American physicians. In 1844, John Watson performed oesophagotomy for the relief of organic stricture of the oesophagus, and in 1886, Richardson demonstrated the accessibility of the entire length of the oesophagus by digital examination, either by gastrotomy or oesophagotomy. In 1823, Milton Antony removed a diseased rib and a large portion of lung tissue, and evacuated a lung abscess. This is one of the first operations upon the lung. In the surgery of the eye, much has been accomplished by specialists, but they have done very little original Work. The revival of old operations, the improvement in the technique of existing ones, and the magnificent results obtained by Agnew, Noyes, Knapp, Bull, Loring, 236 NEW YORK STATE MEDICAL ASSOCIATION. Kip, Callan, and Roosa, characterise this department of Surgery. The introduction of cocaine as an anaesthetic, by Koller, then of Vienna, but now of this city, is one of the most important discoveries of the century, as is also Dr. Leonard Corning's remarkable discovery of a method of prolonging the cocaine anaesthesia, by making pressure in such a way as to retain the drug within prescribed limits. The discovery that water may act as a local anaesthetic, was made in 1885, by Halsted, of Baltimore. In the surgery of the ear important work has also been accomplished. The removal of the ossicles by Sexton and Burnett, the removal of the stapes by Blake, the operation for correction of prominent auricles, by Keen and Monk, the invention of the artificial leech by Bacon, and the operation of trephining the mastoid cells, as per- formed by Crosby, Alfred Post, Agnew, Buck, Knapp, Roosa, Gruening, and Pomeroy, are among the chief Operations. In the surgery of the nerves the work performed by Americans is most commendable. In 1869, Warren, of Baltimore, excised the head of the humerus to re- lieve severe brachial neuralgia produced by pressure of the dislocated head upon the plexus. In 1876, Mears subcutaneously divided the humerus, and thus produced a false joint. In 1871, Sands excised a piece of the brachial plexus for the relief of persistent neuralgia of a traumatic character. In 1856, Carnochan excised the second branch of the fifth cranial nerve beyond Meckel’s ganglion, for the relief of tic-douloureux, and two years later, Pancoast performed the same operation in the pterygo-maxillary fossa. In 1863, Gross removed the inferior maxillary branch of the same nerve. In 1873, Morton dissected out the perinaeal nerve for in- tense neuralgia of the parts to which it is distributed. This same operator cut out nearly two inches of the Sciatic nerve to relieve elephantiasis, in a patient upon whom he previously had performed Carnochan's Oper- ACHIEVEMENTS OF AMERICAN SURGERY. 237 ation of ligation of the femoral artery. S. W. Gross, for the first time in the history of surgery, excised nearly two inches of the spinal accessory nerve, and performed tenotomy of the sterno-cleido mastoid muscle, to cure torticollis. In 1870, Dr. Sayre pointed out the relation between paralysis and peripheral irritation as observed in congenital cases of adherent prepuce. The telephone is an American invention, which has been applied to practical surgery. The author reports a case of an intubation-tube which had by accident fallen into the trachea, and which was removed by him, as soon as the lodgment of it was made certain by the telephone needle-probe devised by Girdner, of this city. Amputations.—In this department of surgery, America has nothing of which to be ashamed. She has not only taken the initiative in the more important amputations, but she has perfected methods devised by eminent sur- geons in other countries. The first successful primary amputation at the hip-joint was performed by a Kentucky surgeon named Brashear, in 1806. The amputation was successfully repeated by Mott, in 1824. Nathan Smith, in 1824, was among the first, if not the first, to success- fully and systematically amputate at the knee-joint, and the technique of this operation has been perfected by Markoe and Stephen Smith, of this city. The first suc- cessful amputation of the ankle-joint in this country was performed by Gross, in 1851. The operation had been performed in 1842, by Syme, in Scotland. The first sys- tematic amputation at the shoulder-joint was performed by Richard Bayley, in 1762. The same operation was also performed by John Warren, in 1781. The first suc- Cessful amputation of the arm, with the clavicle and Scapula, was performed by Dixi Crosby, in 1836. Amos Twitchell and MacClellan performed the same operation Successfully in 1838. Triple simultaneous amputations have been successfully performed by Ashhurst, Ruckie, Stone, Reid, Koebler, and others; while Wallace has Successfully performed a quadruple amputation. These 238 NEW YORK STATE MEDICAL ASSOCIATION. are among the curiosities of surgery, and illustrate the preservation of human life, in face of the greatest danger. Thus it is evident that American surgery has not only taken the initiative, but has successfully performed many of the major amputations; and when the number of them is considered, what has been left for other countries to claim in regard to this special field of operative surgery'. In the invention of prothetic apparatus, the ingenuity of the American mind has discovered a most wonderful field of operation, since in no country can be found the mechanism displayed in the aluminum manufacture of artificial limbs. I know of patients who can walk well, and even run, with two artificial limbs, and of one with artificial hands, who is employed as a pharmacist, and is able to weigh medicine on the most finely adjusted balance. Staphylorrhaphy was performed by Dr. John C. War- ren, in 1820. The same year, it is just to state, the oper- ation was performed in France, by Roux, but Warren had no knowledge of Roux's method. It has been also stated that this operation had been previously executed in Poland; but no authentic statement is extant as to who the surgeon was, or at what place or time the operation was performed. - Myotomy of the masseter muscle was first performed by Schmidt, of New York, and he was followed by Mut- ter, of Philadelphia. Both of these operations preceded the work of Dieffenbach and Fergusson. Excision of the tonsil was placed upon a safe and per- manent basis, by Dr. Cox, of New York. This surgeon invented, in 1820, an instrument which included the ton- sil in a ring, and then cut it by a ring-shaped knife. The guillotine principle, applied to the tonsillotome, was an improvement upon this instrument. Previous to 1820, the method of Desault was in vogue. This consisted in tying off the tonsil, and permitting it to separate by a process of Sloughing, which occupied six days. The evolution of the present guillotine tonsillotome is ACHIEVEMENTS OF AMERICAN SURGERY. 239 one of great interest. Dr. John C. Warren, of Boston, about 1835, attempted to remove the tonsils of Mr. Caleb Eddy's boy, and the instrument worked so unsatisfac- torily that Mr. Eddy remarked to Dr. Warren, at the completion of the operation, that this crude instrument was “Sullivan’s Machine,” and that he would make one for him, better adapted to the purpose. In order to ap- preciate this terse and sarcastic remark, it is necessary to recall some historical facts. In the old Salem canal, the grass grew so luxuriantly that it impeded the progress of the slow canal boats; and Mr. Sullivan, the superintendent, devised a machine, known afterward as “Sullivan’s Machine,” which con- sisted of a sort of Scythe, which was set upon a frame, and attached to the stern of the canal boat. As the canal boat was hauled through the waterway, the grass was supposed to be cut by the blade swung from the stern of the boat. As a matter of fact, the grass was simply pushed down in front of the knife, instead of being cut by it. Mr. Caleb Eddy, appreciating the mechanical defects of this cutting apparatus, suggested placing the knife at an angle, and then the grass was cut down as the boat Was dragged through the canal. The guillotine tonsil- lotome of the present day owes its efficiency to this in- cident. I have been very much surprised to find how many Surgical instruments have had a similar origin. The American mind is wonderfully prolific in invention, and has adopted, improved, and perfected many a sur- gical instrument from the mechanics of every-day life. In the departments of the throat and nose, American Surgery has accomplished excellent results. The opera- tion for the relief of catarrh by the use of the saws in- Vented by Bosworth, and by Bucklin ; the removal of polypi by the snare, devised by Jarvis ; Curtis's method of curing nasal stenosis by the nasal trephine; the im- provement of Elsberg's forceps by Beverley Robinson, all deserve the highest commendation. In 1866, Cheever, of 240 NEW YORK STATE MEDICALL ASSOCIATION. Boston, was the first surgeon to remove a carcinomatous tonsil by an operation through the neck. The work of Bosworth, Lincoln, Delavan and Chapman in this depart- ment, also deserves special commendation. Tiffany, in 1878, removed successfully a naso-pharyngeal polypus, by first depressing temporarily the two upper jaws, having performed a prophylactic tracheotomy. The operation of intubation is one that reflects great credit upon American surgery. The dyspnoea of laryn- geal stenosis depending upon the pressure of a pseudo- membrane, or a stenosis the result of a chronic inflam- matory thickening, are relieved by the introduction of a tube through the mouth into the larynx. This is not the place or the occasion to enter into the merits or demerits of intubation of the larynx as compared with trache- otomy; suffice it to say, that the awful dyspnoeal dis- tress among children suffering from croup or diphtheria has been in a large measure relieved, and the mortality of the operation, based upon 806 cases, is 27.4 per cent. This mortality is the result obtained from a list of the cases furnished by many operators, while individual operators have obtained as high as thirty-eight per cent. of recoveries. Few can realise the wide-spreading in- fluence of this operation for the relief of one of the most dreadful of diseases. To Dr. Joseph O'Dwyer the en- tire profession owes a debt of gratitude. “The perse- verance, ingenuity, and originality shown in perfecting the method merit our admiration.” Finally, I heartily indorse the Sentiment expressed by Dr. Ingals, and join “in acknowledging the nobleness of the profession at large, which tolerates no secret method, but generously donates to mankind every improvement in the healing art. Among the latest, but not the least, may be classed intubation, rightly considered as one of the great ad- vances of medical discoveries.” In considering this great discovery and invention by Dr. O'Dwyer, the long list of brilliant operators who have perfected and demonstrated the success of the Oper- ACHIEVEMENTS OF AMERICAN SURGERY. 241 ation, deserve recognition, among whom may be men- tioned Dillon Brown, who has intubated six hundred and sixty-eight cases, with a little over thirty per cent. Of recoveries; Waxham, Huber, Eichberg, Montgomery, Gay, McNaughton, Pyne, and others, who have per- formed many intubations with brilliant success. In the investigation of malignant tumors American surgeons have displayed great ability. The early work of Warren, of Boston, was among the first attempts to systematically collect and study neoplasms from a clinical point of view. The writings of Gross upon tumors de- mand more than a passing notice, while the contributions of Shrady and of Mudd to cancer of the tongue, are most exhaustive. The results after operation for carcinoma of the breast, afford an example of what has been accom- plished in this country, for the permanent recoveries have now reached over thirty per cent., while fourteen per cent. represents the best results in Great Britain. In sarcoma the results are even more favorable. J. Collins Warren’s method of examining a part of a tumor before operation by his special instrument, is most useful and ingenious. The work of White, in the surgery of the spinal cord, of Watson, in concussion of the cord, of Westbrook, in tapping the ventricle of the heart, of Gerster, Pilcher, and Fowler, in the perfection of antiseptic technique, of Dawbarn, in hypodermatic injection of serum in large blood-vessels, as a substitute for transfusions—all de- Serve special commendation. The writings of Agnew and Ashhurst, which have widely disseminated surgical literature, the investigations of Jarvis White upon the Subject of asymmetry of limbs, the work of Yale, in tuberculosis of joints and bone, and of Ranney, in the ºy of the nerves, also deserve most honorable men- lC)11. In plastic surgery, American operators have been most Successful in their work. The formation by Pancoast of a nose from the forehead, by the modified Indian method, the building of a nose from the phalanx by Sabine, and 16 242 NEW YORK STATE MEDICAL ASSOCIATION. the treatment by Mutter of cicatrices after burns, are all operations illustrating the versatile genius of the Ameri- can mind. The plastic surgery of the mouth has been advanced by Goodwillie, whose results in this depart- ment of surgery have been presented to the profession. In the invention, perfection, and manufacture of Surgi- cal instruments, America eclipses the world. It was my intention to collect for the purposes of practical demon- stration, a sample of every surgical instrument invented and made by Yankee ingenuity; but I was informed that Over One hundred thousand dollars would not cover the expenses of such an outlay. I have, therefore, been obliged to abandon that project in full, and have arranged to show as many as possible of the modern instruments of purely American invention, in order that the members of this Association can form some general idea of the credit to which our country is entitled for their share in the armamentarium of the surgeon. It is certainly a most praiseworthy fact, that there is no operation in all Surgery which cannot be performed by instruments invented in this country and manufactured by American artisans. This statement embraces a wide field, and an examination of the array of surgical instruments will convince anyone of the correctness of this opinion. It is but a short time since the French imported surgical instruments were almost a necessity; but nowadays the most perfect and precise instrument is made in our own country, with steel which eclipses that of any other nation. For work- manship, for precision, for lightness, for durability, for strength and beauty, the work of American artisans is superior to those of any other country. The impartiality of our countrymen has enabled us to seize upon the best from wherever it emanates. Ameri- can surgeons have gleaned the harvest from all nations. During our colonial days, Great Britain and France were foremost in the achievements of surgery, but their feelings of hated rivalry and national jealousy precluded the pos- sibility of their adopting anything good from one another. AOHIEVEMENT'S OF AMERICAN SURGERY. 243 In late years, this same spirit pervaded France and Ger- many. The want of reciprocity has hindered the advance of surgery in both of these rival nations. As an illustra- tion of this statement, I may cite the fact, that in 1823, the writings of the great French surgeon Desault had not yet been translated for the use of English surgeons, while at that time, Dr. E. D. Smith, of South Carolina, was engaged in the translation of this work for the ben- efit of American surgeons. In the great triangle of nations, formed by England, France and Germany, the good of each remained within its own domain. America, on the other hand, eagerly seized upon all the good from these and other nations, and she appropriated to her own use all principles, theories, discoveries, inventions, and knowledge, and utilising these factors, she has made her onward march illustrious. With the wonderful adaptability of the American mind, with its easy susceptibility in its early plastic condition, these impressions have been made, and their results in surgery are as enduring in their potential influence, as the ocean which separates us from the Old World. Finally, gentlemen, this brief review of the early and present achievements of American Surgery, demonstrates the fact, that our country has nothing of which to be ashamed in estimating her share in the evolution of this great science. Our contributions to surgery, in general, are now matters of record for the study of all nations. If what America has accomplished in the past be elimi- nated from the sum total of the surgical work of the World, there is little left to the older nations. There are many things which explain the prominent position which America has taken in the consummation of this great work. Chief among them may be men- tioned the innate courage which our Puritan ancestors DOSSessed. The same undaunted bravery which spurred the Puritans to cross the great unknown ocean, and to Settle in the primeval forest for the purpose of exercising their liberty, stirred them to great efforts on behalf of 244 JNETW YORK STATE MEDIOAL ASSOOIATION. Surgery, and made them fearless and bold. The self- reliance of the early settlers in this country, and their manly independence were characteristics necessary to win Success in the art of surgery, without which Ameri- can Surgery would never have obtained the high place it now holds in the estimation of the civilised world. MEMORANDA, PRACTICAL AND SUGGESTIVE. By H. D. DIDAMA, M. D., of Onondaga County. November 16, 1892. (a) EARLY ASPIRATION IN PLEURITIS. Many cases of pleuritis, especially of the dry form, where the quantity of effusion is small, get well with little or no treatment. The patients, in these instances, are usually blessed with excellent constitutions, and a habitual vigor, which is elastic. In other cases, where the attack is more severe, recovery also occurs under the use of cathartics, diuretics, sudorifics and blisters, with Or without total abstinence from water or other bever- age; but convalescence is tedious, and recovery often incomplete. Furthermore, in a large percentage of cases, the therapeutic management just indicated fails entirely to Secure a favorable termination, so that the thoughtful medical attendant is sometimes perplexed to determine whether the unsatisfactory course is due wholly to the malignancy of the disease, or in part to the imperfection of the treatment. The consensus of modern medical opinion, as expressed in books, is that after giving the remedies a fair oppor- tunity, and a reasonably generous time to secure the absorption of the pleural effusion, if the desired object is not accomplished, or if the amount of the transudation rapidly becomes so great as to imperil the life of the patient, the effusion should be partially removed by the Operation of peracentesis. The limit of this probation- any period, and the danger-symptoms and signs which should be manifest before instrumental interference is justifiable, are variously set forth by different authors. If the flatness on percussion does not extend well above the nipple, and if dyspnoea be not very severe, ten days, 246 NEW YORK STATE MEDICAL ASSOCIATION. to four or more weeks, would fairly cover the period of waiting and watching proposed by conservative experience. . - For several years, a minority of physicians, including the writer, have pursued a different course, with more satisfactory results. They do not regard active cathar- sis, diuresis, or diaphoresis as an essential or important part of the treatment. Anodynes and strapping are em- ployed while the pain is severe, and tonics, such as qui- nine, iron, and strychnine, are administered, if the patient —as he often, and she usually—is in a weak condition ; and then, when with mitigation of pain, and some sub- sidence of fever, percussion shows that fluid is present, even if the amount does not exceed an estimated half- pint, aspiration is performed. The diagnosis is verified, and the depth of the trocar puncture determined, by the hypodermic needle ; clean- liness of skin and instruments is secured; and the oper- ation, at this early period, is done while the patient is in a sitting posture. No effort is made to leave a portion of the effusion to be removed by absorbents. As a rule, which has scarcely an exception in the practice of the writer, a repetition of the operation is not needed ; the lung expands, normal respiratory sounds reappear, and the friction fremitus returns with exaggerated distinct- ness. More or less pain or discomfort is felt in the af- fected side, but convalescence is rapid and unattended with great prostration, and the recovery is complete. The experience of the writer has been reasonably exten- sive. He has had at least forty original cases, where he has performed aspiration early ; and the outcome has been such that he has no inclination to resort to any other treatment now known to him. He has been called to a considerable number of cases where a diagnosis of a hep- atised lung, or enlarged liver, or malign tumors had been made, and also in consultation to several cases where an early and correct diagnosis had been made, and the most vigorous antiphlogistic and eliminative treatment had MEMORANDA, PRACTIOAL AND SUGGESTIVE. 247 been pursued from the outset. In these cases, and in these only, has he found the cautions laid down by the authorities important. In some instances, the lung, crowded or retracted to the upper part of the chest, had become imprisoned by adhesions, and even carnified, so that it could not expand; while the heart was pushed or drawn over, so that its pulsations were palpable and visible at the right of the sternum. Only a portion of the fluid could be removed without exciting violent fits of coughing, and not unfre- quently, after a few days, a repetition of the operation was demanded. In a few instances, where some of the patients were young and previously healthy, pyothorax was present, apparently, because an early operation had been performed, owing to the reliance on authorised medication, or because a faulty diagnosis had been made. The supporting and alleviating treatment of pleuritis, combined with early thoracentesis, seems to possess the following positive and negative advantages: It is easily and safely done ; it does not add to the local inflamma- tion, but actually relieves and shortens it ; it is not debilitating ; it removes, in a few minutes, a quantity of fluid which could not be removed through the skin, kid- neys, and bowels in many hours, days, or even weeks; and it does all this without causing weakness and slow recovery ; it prevents that carnification of the lung, and those tender adhesions, which in late aspirations eventu- ate in deformity of the chest, and haemorrhage into the pleural cavity; it prevents congestion of the lung on the unaffected side, and injurious dilatation of the right ven- tricle; it probably secures exemption from empyema In many cases; and, if it be true (as some active writers vehemently claim) that every case of pleuritis is tuber- cular, then this treatment, like the prompt removal of the fluid in tubercular ascites, is decidedly the most efficacious in preventing or arresting general bacillary infection. In short, it averts death, and safely, easily, Promptly and permanently cures the patient. 248 NEW YORK STATE MEDICAL ASSOCIATION. (b) MINERAL WATERS, CRUDE AND REFINED. An examination of the analyses of the various mineral waters of the United States, and elsewhere, seems to warrant the following statements: 1. Many of the waters, like those of Saratoga, Carls- bad and Crab Orchard, contain a cathartic salt in such quantity that from half a pint to a quart of the beverage will act as an efficient laxative. One excellence of these purgatives, is that they can be taken daily for an in- definite period without injury. 2. The activity of a salt designed to move the bowels is much impaired by excessive dilution. A Saline Solu- tion, whose specific gravity is less than that of serum, passes largely by Osmosis into the blood and out through the kidneys, instead of drawing water from the circula- tion and acting as a laxative. 3. Many, indeed most, of the really valuable natural, crude, mineral springs contain ingredients which in Quantity or quality are detrimental. The famous Sprudel spring, and many others, whose active principle is Glauber's Salt, have too large a percentage of lime. The Saratoga waters possess too much sodium chloride, as well as calcic salts. The aqueous beverage now indulged in by Syracuse people at home (soon to be displaced by the sparkling and bright Skaneateles Lake water) is decidedly hard, but it contains only two and a half grains of lime salts in a pint, while the Congress and Hathorn contain respectively more than twelve and fourteen grains. Apropos of these waters, it may be re- marked, that the Congress has nine grains of carbonate of magnesia, and fifty grains of common salt in a pint, and the Hathorn has but three more grains of the mag- nesium salt and thirteen grains more of the sodium chloride; yet the genial and reverend Theodore Cuyler, who summers at a sanitarium in Saratoga, ventures the assertion, that “Hathorn water is as pungently drastic as high Calvinism ; but the Congress Spring has a some- MEMORANDA, PRACTIOAL AND SUGGESTIVE. 249 what milder quality—about like the modified Calvinism recommended by the Revision Committee. Congress water is about the right thing after all for a regular morning potation.” 4. An ideal, artificial, refined mineral water, which shall not contain objectional ingredients, and which shall possess, in a concentrated form, all desirable qualities at a reasonable price, can be manufactured by any capable chemist. Lithia Springs contain the material from which their name is derived, in such minute quantity, that a person must imbibe one or two gallons of the water to obtain a medium dose of the medicine. The Virginia Buffalo Lithia Springs have but two grains of lithium salt, and thirty-nine grains of lime, in a gallon ; while an artificial lithia water (called, funnily enough, “Hudor water”) contains sixty grains of lithia in a gallon, with all useless and faulty substances left out. So that this One gallon, therefore, of this artificial product is equal to a barrel of the Virginia water, when lithium is required Or desired, and is immensely superior to the crude natural variety. 5. But it is well enough to remember that no salt of lithium is equal in its solvent power over uric acid to the same quantity of citrate of potassium. 6. Waunted Springs which, like the Poland, and Others, contain hardly any appreciable amount of any mineral (the Poland having a total of about three grains to the gallon, two-thirds of this being lime and silica) may still be beneficial if used in the enormously large Quantities directed and urged by their proprietors. Their location may be where the air is invigorating and germless; where the weary invalid is liberated from the Care of business, relieved to some extent of the deceitful- neSS-certainly of the plethora—of riches, and flushed out every few hours with an amount of fluid for which he never dreamed he had a capacity. Divesting himself of prejudice, he would probably find that an equal quan- 250 NEW YORK STATE MEDICAL ASSOCIATION. tity of pure water at home would (so far as the water is concerned) be equally beneficial; and it is well to con- sider that the pecuniary condition of the average patient will not allow the luxury of a distant journey, and a board bill of five dollars a day. 7. The notion that the natural heat of the earth imparts to water any virtue which could not be derived from solar or stove heat, has no scientific or experimental foundation. Watrium iodidum is known to be a potent weapon in the armamentarium of the Hot Springs medi- cine-man. The writer has never sent a patient to the National Calidarium, but he has treated with satisfaction several who have returned unbenefited from that popular, but Somewhat compromising resort. (c) COUGHING MADE EASY IN BRONCHIECTASIS. A few years ago, at Skaneateles Junction, there resided an old lady who had been for many months troubled with a cough which her friends regarded as consumptive. The cough was severe enough at all times, but twice or thrice in twenty-four hours, there were violent, long-continued paroxysms, attended with copious and extremely foetid expectoration. I recognised, as you all would, bronchiectasis. The patient had not derived much benefit from the cod-liver oil and numerous cough medicines which she had taken faithfully in great abundance. Her appearance did not denote the existence of tuberculosis ; and, under a change of treatment, relief was afforded, the paroxysms ceased, and the offensive odor disappeared. Recently, Mrs. H., of C., about thirty-five years of age, came under my observation. She had had bronchial catarrh for a year and a half, and a few slight haemor- rhages. After a time, the cough became paroxysmal, and during these violent fits, which lasted without sensible mitigation from sixty minutes to three hours, the copious MEMORANDA, PRACTICAL AND SUGGESTIVE. 251 expectoration was so offensive that the windows had to be kept open. The disease was thought to be tubercu- lous, or cancerous ulceration, or gangrene of the stomach; for vomiting was of frequent occurrence, and the odor of the vomited material was also, as the patient expressed it, “enough to knock anybody down.” At my first visit, the patient was found weak and ema- ciated, but without the tuberculous or cancerous facial expression. The scent of the expectoration fairly justi- fied the description given. The history showed that enough food was taken, but that two or three times a day it was all vomited, and that these vomiting spells coincided with the severe spells of coughing. There was some diarrhoea, but the odor of the alvine discharges was entirely unlike that of the vomited material. There was no gastralgia, and no tenderness in the epigastric region. The diagnosis, of course, was uncomplicated bronchiectasis, and the rationale of the symptoms was Obvious. If the stomach had been involved, the stools Would have possessed the peculiar odor of the sputa. Nausea and vomiting, which were excited by the violent Coughing and the repulsive smell, increased mechani- cally the amount of the putrid material expectorated, and this, mingled with the ejected food, perfumed the Whole mass, and led to the mistaken diagnosis of gastric ulceration or gangrene. - Proper explanations were made, and encouragements given to the intelligent patient, and a therapeutic plan Was instituted, which included tonics of iron, strychnine, Venice turpentine, Santal, et cetera, and the use, with a Steam atomiser, of a deodorising spray. Perhaps the most important element in the treatment of this case, and the one at the Junction, was the emphatic and iterated direction to cough downwards. The usual and proper information was given to the patient, that a pocket was formed in the tubes of the lungs, and that when this pocket became filled and run- ning over, as it did two or three times a day, the 252 NEW YORK STATE MED TO AL ASSOCIATION. unpleasant and irritating material caused the terrible fits of coughing. The walls of the pocket, it was further explained, were so thick, that even the most violent and long-continued attacks could not compress them enough to empty the pocket entirely, and so a portion of the putrid matter remained to contaminate future collec- tions. Now by lying in bed, or on the lounge, the patient was told, with one hand on the floor and the head almost reaching there, the pocket would be inverted, and the fluid would run out almost of itself, and its expulsion would be hastened by a short spell of coughing. The direction was given not to wait until the pocket became wholly filled again, but to anticipate this period by inversion four or five times daily. The injunctions were obeyed; the result was favorable. In five minutes, the pocket was emptied more com- pletely than when she had formerly “coughed her head off” for an hour or longer; the odor disappeared, vomiting and diarrhoea ceased, the flesh came back; and to-day, with the exception of a slight cough, and a few mucous râles in the left infra-axillary region, the grate- ful patient, who rides twenty miles to town every two weeks for inspection, is decidedly convalescent. It is proper to add, that the idea of coughing down hill was derived from a small pamphlet, published nearly fifty years ago by the poet N. P. Willis, who claimed that he had cured himself of consumption by this origi- nal device, and by horseback exercise. In all proba- bility, his supposed consumption was bronchiectasis, but his suggestion is none the less valuable ; and the writer of this paper has known great, even if temporary, relief and comfort to be obtained by this gravity treat- ment, in cases of phthisis, when large cavities, and excessively annoying coughs existed. Only a week before this annual meeting, I was invited to See a patient who had a cavity in the right infraclavic- ular region, capacious enough to hold a teacupful of muco- pus. He discovered that, while lying on his right side, he MEMORANDA, PRAOTICAL AND SUGGESTIVE. 253 could sleep three or four hours with but little disturb- ance, but that if—after this period of repose—he turned upon his left side, a brief fit of coughing ensued. If he attempted to sleep, lying on his left side, the cough was incessant, and the Sputa Only moderate in amount. Every one present can see without explanation, that while in one position the Secretion accumulated, exciting in the nerveless pocket little or no cough, till the reser- voir was filled, and that on turning over, the irritating material ran out by gravity into the sensitive bronchi, and produced an easy cough, sufficiently prolonged to secure thorough evacuation; in the other position, on the left side, there was a continual dripping from the abscess cavity, and a wearing cough which banished sleep. Two mornings ago, as I learn, the patient, after a prolonged sleep, which lasted all night, turned upon his left side. The large amount of pus which had been permitted to accumulate during this long period, poured out suddenly into the tubes, and produced strangulation and almost instant death. It is respectfully submitted that this facilis descensus treatment might be so beneficial in some cases of real or Supposed gangrene of the lung, communicating with a bronchus, that pneumonectomy might be unnecessary. (d) THE INSURANCE SPONGE. The Sponge is an animal; that question is settled; the Vegetarians have ceased to claim it. Like the vanquished party in the recent presidential contest, they surrendered reluctantly, but they surrendered. “In its simplest form,” so the naturalists inform us, “the sponge is homologically a single animal with the internal structure and function of a colonial organisation.” There are many Varieties of sponge: the spongia equina is the horse sponge of the bath-room; the spongia dura is the hardhead found in America; the cup sponge and glove sponge are fine Species used in surgery. All these are marine varieties. 254 NEW YORK STATE MEDICAL ASSOCIATION. “None of them seem to be truly parasitic—that is, capable of living upon the substance of other animals.” But there are land sponges. These also are single animals, with the structure and function of organised colonies. Unlike the sea sponges, these land lubbers are truly, and with emphasis, parasitic, that is, they do actually live upon the substance, the juices, the circula- ting medium of other animals. The tramp is a Sponge—a combination of Spongia dura and spongia eſ/wina. He has facial petrifaction united with the peripatetic propensity of the walking delegate. A sponge possesses the property of enormous absorp- tion and retention ; but of its own volition it disburses nothing. Firm compression is necessary to secure dis- gorgement. Spongia cerebriform is is a common enough species, but Spongia corda—the sponge with a heart—is an exceedingly rare, but not inconceivable variety. This, by natural gradation, brings us to the subject under consideration. A Life Insurance Company is a sponge. It belongs to the family of octopeda or millipoda. It has a head- centre ; grasping arms, which extend to immense dis- tances; agents as suckers; and medicine-men as ten- tacles or feelers. Through its agents it sucks into its colonial meshes such an enormous surplus of nutriment, that it permits its chief sucker to retain fifty per cent. of the premium blood drawn from the veins of each newly captured victim ; while its corpulent head-centre ap- propriates an amount of this same vital fluid, which, if transmuted into coin, would equal from ten thousand to Seventy thousand ducats annually. The tentacles decide as to the sanitary condition of the victims. They receive scanty pabulum for their services, which are, or should be, of the greatest value. The judgment of other medical men (especially those of recognised prominence) as to the ability and fitness of the tentacles, is constantly sought by the head-centre. The opinion desired may be of immense importance ; it MEMORANDA, PRACTICAL AND SUGGESTIVE. 255 may ensure success, or ward off disaster; but the insur- ance octopus Sponges the Opinion ; he disgorges no ducats; he emits not even a worthless thank. He propounds, in a circular, a series of questions as to the age of the tentacle whom he purposes to employ, when and where he was educated, his qualifications as a diagnostician, the acuteness of his senses, especially his hearing, the amount of his business; his shrewdness, his mental and moral integrity, his ability to resist the allurements of the willing victim, and the anxious sucker ; his social and professional Standing ; and then he craftily pretends that the valuable time spent in answering fully these and many more Searching questions, is for the sole benefit of the proposed tentacle ; while at every moment he knows that the pretense is a false one, and employed. Only to excuse Sponging the wished- for information from the meek and complaisant physician. More than this. He is guilty of the contemptible meanness of promising that if the friendly tentacle shall be maligned and betrayed, the gratuitous betrayal will be guarded sacredly as “confidential.” In the good time coming, slowly coming, some insur- ance millipod may, by evolution or compulsion, emerge from his spongy condition. Then he will send with his circular questions, not only the generous two-cent post- age Stamp, but a suitable fee for careful answers ; then he will frankly acknowledge the truth, that the infor- mation sought is for the protection of the organisation ; then he will be independent enough and shrewd enough to proclaim, that whatever other associations may sneak- ingly do, his company is able and willing to pay, and actually does pay, for all services rendered. When this salutary transformation shall have been effected, the busy doctor will no longer throw, with resentful disgust, the insurance circulars into the waste basket; but he will regard himself as the compensated agent of a cordate and honorable association, which deserves respect and success, and whose interests he will gladly seek to promote. ACUTE PLEURISY. By FRANK S. PARSONs, M. D., of Northampton, Mass. November 17, 1892. The intelligent classification of an inflammatory affec- tion of a serous membrane, and especially of the pleura, is not an easy task. The terms “acute,” “subacute,” and “chronic,” which have been applied to diseases of that nature, are often subjects of much criticism, no matter from what pathological lesions, or symptomatic indications, they may be derived, and I can only hope that I shall not fall into the common error of making them more intricate. The term acute pleurisy indicates an inflammatory condition of the serous membrane lining the pleural cavity, in which the height of the disease is attained in a few days, ten at the most, and accompanied by an appre- ciable rise in temperature. It may be dependent on pre-existing disease or lesions, or it may be an idiopathic disease. Pathology.—Hyperaemia, or congestion of the blood- vessels within the serous and subserous connective tissue, causing swelling, redness, and oedema of the pleura, is the first noticeable lesion of acute idiopathic pleurisy. This congestion may be at first localised, and rapidly extend, or it may, from the first, be quite general. Soon the smaller and weaker capillary vessels rupture, pro- ducing ecchymosed spots over the membrane, and, at the same time, infiltration of the subserous connective tissue occurs, with proliferation and detachment of epithelial cells. As the process progresses, the pleura appears studded with fine granulations, in which appear embryonic cells. A CUTE PLEURISY. 257 These tend to organise the newly formed connective tissue into firm fibrinous bands, which are often found stretching across the pleural cavity, in old cases, and which constitute the so-called neo-membranes. Finally, the congested serous membrane pours out a fluid, resembling in all respects the plasma of the blood except that it is more dilute. Red blood corpuscles and leuco- cytes are to be found in the liquid, but in simple sero- fibrinous pleurisy, the red globules are not in sufficient numbers to cause any marked discoloration. “Inflammation,” says M. Germain Sée,” “is a struggle for life and not a destructive process; it is essentially a vital phenomenon eminently reactionary against a mor- bid agent.” He believes that micro-biology teaches that inflammation is a strongly exaggerated physiological process, a general struggle of the Organism against microbic invaders. “The first step in this process,” says he, “is leucocytosis, or the exaggerated production of white blood corpuscles in the blood; and the second, called phagocytosis, is the absorption and destruction of micro-organisms by these leucocytes, showing the de- fensive action of the latter. The French supporters of the germ theory of disease, believe that when microbes have penetrated the organ- ism, the leucocytes increase, and that the condition which brings them to the blood, carries them to the point of excitement. In acute inflammations there are three stages of de- Velopment: first, vascular dilatation ; secondly, activity and proliferation of endothelium ; thirdly, exudation, With diapedesis of leucocytes. As a consequence of these three stages, it is claimed, a great afflux of phagocytes takes place towards the point of attack, both in puru- lent, as well as catarrhal inflammations. , Purulence is considered no exaggeration of inflamma- tion, but due primarily to the action of the streptococcus or Staphylococcus; and, although great numbers of * Bulletin de L'Académie de Médicine, May 10, 1892, p. 680. 17 258 NEW YORK STATE MEDICAL ASSOOIATION. phagocytes may be found, their defensive action is much harassed by their deadly enemy, the pus germs. We may conclude from the foregoing, if we are to accept this doctrine, that inflammation is a physiological process to develop phagocytes against microbes. Anatomically, the pleura is a great lymphatic Sac, con- tiguous with the arterio-pulmonary system, and natur- ally deriving its serosity from that source. According to the eminent French teacher, M. Guerin,” “pleurisy is nothing else than lymphangitis.” “If one injects the pulmonary artery,” says Guerin, “with colored liquid, it will be found that the liquid will appear in the polygonal ramifications of the lym- phatics of the pleura.” Moreover, he has practiced on the cadaver, injecting bullocks' blood in the same manner, and finds that he obtains a serosity from the pleura, which, if much force be used in the process of injecting, becomes bloody, or red in color. If, on the other hand, he injects a colored liquid in a subject who has suffered and died from pleurisy, there will be found no coloring matter in the meshes of the lymphatics, except those which have not been affected by the inflammatory pro- CéSS. If this be true, we can readily see that when from some cause the lymphatics of the pleura become congested and Swollen, and the natural channels for the lymph impeded, an oedematous condition of the subserous con- nective tissue will arise, due to forced diapedesis of the Serosity, and will cause the fluid to ooze from all parts into the cavity. If, then, the lymphatic stoppage be complete enough, and the force behind sufficiently strong, there will be more or less diapedesis of red blood corpuscles also, hence the haemorrhagic pleurisy. If we find leucocytes in the lymphatic exudation, does that not offer the best explanation of the formation of pus : * Bulletin de L'Académie de Médicine, April 26, 1892. AOUTE PLEURISY. 259 It has been stated that the serosity of acute pleurisy does not differ materially from the plasma of the blood; if drawn off, it will coagulate, often spontaneously ; if beaten or whipped, it will show a deposit of fibrin ; and the constituents are the same as the plasma of the blood, differing only in their relative proportions. From the fact that the aspirating needle often becomes clogged with fibrinous flocculi, it is argued by M. Lanceraux," that these flocculi clog the openings of the lymphatics, and by the thrombi thus formed produce a mechanical hindrance to the exit of the effused fluid. Hence, in some cases, according to this author, “one must wait for the disintegration and absorption of the clot, before any diminution of the quantity of the fluid by nature takes place.” I can see no reason for the opinion held by some authors, that every pleurisy is dependent on lesions of pre-existing maladies, and especially on tuberculosis. Aetiology.—In considering the causation of acute pleu- risy, one must of necessity admit that from an aetiolog- ical point of view there are two general classifications: those which are and those which are not due to any pre- existing disease. - At the present day, there are many and diverse opin- ions concerning the production of idiopathic pleurisy ; in- deed, there are those who would go so far as to say that all pleurisies are tubercular in origin, and, hence, second- ary, but this seems to me to be going farther than our pathological researches would warrant. I doubt not, if the chests of many persons, who to-day are in good health, and have never been aware of having had pleu- risy, were opened, we would find various traces of old adhesions and other lesions of former pleurisies. It must be admitted, therefore, that neither the microbe nor any other one causative factor, will account for all Cases of acute pleurisy. * Bulletin de L'Académie, de Médicine, May 31, 1892, p. 661, et seq. 260 NEW YORK STATE MEDICAL ASSOCIATION. While it is difficult to state with certainty that pleu- risy originates in perfectly healthy persons, because latent pathological lesions cannot be appreciated, we know that it does occur in persons who to all appear- ances are in good health. M. Sée maintains that the aetiology of acute pleurisy is always due to microbes, and that cold is simply a stimulus to the activity and development of the micro- Organisms. Netter” claims that all forms of pleurisy are of microbic origin, but that the microbes producing them are of many different kinds. M. Bechamp" says: “Microbes do not have so much importance in acute pleurisy as some would have them,” and he is certain that pleurisy may exist independently of tuberculosis, from the fact that although at the age of thirty he was seized with acute pleurisy, and treated by the usual bleeding, blistering, and purging, he is still alive at the age of seventy-six, and has not developed tuberculosis. Furthermore, in support of this, both he and Dieulafoy state, that many persons live ten or fifteen years, or even longer, after the operation of thoracente- sis, and do not develop tuberculosis. That exposure to cold has a tendency to excite inflammations, and with them acute pleurisy, there can be no doubt ; but whether it causes pleurisy directly through its influence on the nerve centres, or whether it acts simply as a stimulus to organised germs, through whose activity the disease originates, is still a much mooted question. M. Tresbot" does not doubt that acute pleurisy in horses is the direct result of an exposure to cold ; and he says: “Ordinarily there is nothing in common between sero-fibrous pleurisy in the horse, and tuberculosis and that it is impossible to class sero-fibrous * Bulletin de L'Académie de Médicine, May 10, 1892. * British Medical Journal, June 2, 1890. * Bulletin de L'Académie de Médicine, June 7, 1892, p. 793. * Bulletin de L'Académie de Médicine, May 17, 1892, p. 758. AOUTE! PLEURISY. 261 pleurisy in the horse with an eruptive fever; or indeed, with any periodic disease.” On the other hand, M. . Lanceraux' asserts, that “pleurisy should be rightly classed among the infectious maladies, and exposure to cold is nothing but an occasional exciting cause.” If we should accept the pathological views of M. Guerin, already mentioned, we might easily explain the congestion of the blood-vessels by peripheral irritation, and reflex action of the vasomotor nerves from exposure to cold ; but this would not explain why such excite- ment should be directed to the pleura in particular. In a paper on “The cause of syncope in pleurisy,” M. La Borde” has shown by experiment on animals, that it is possible to produce a sero-fibrous pleurisy in a few hours, by the action of cantharidin injected into the blood. This leads me to ask, Is the causation of acute primary pleurisy ever governed by the ingestion of cer- tain articles of food just previous to an exposure to cold ; and would the combination of these two factors be sufficient to direct the inflammatory action towards the pleura ; Purulent pleurisies are originally of micro- bic origin, or are secondary to other diseases. Age and debility are also important factors in their production. It is doubtful if simple sero-fibrous pleurisies ever turn to the purulent form without outside interference. Secondary pleurisies occur from a variety of causes, mostly from diseases microbic in origin. While it may be rare to have pneumonia occur without some localised extension of inflammation to the pleura, it is doubtful if a general acute pleurisy, secondary to pneumonia, will be found without numerous pneumococci. In the same manner, the causation of pleurisy, during an epidemic of typhoid fever, influenza, malarial fever, rheumatism, or kindred diseases, is undoubtedly due to the same influences which govern the co-existing disease. *Bulletin de L'Académie de Médicine, May 8, 1892. * Bulletin de L'Académie de Médicine, May 17, 1892, p. 709. 262 NEW YORK STATE MEDICAL ASSOCIATION, It is well known that pleurisy of an acute type may be Secondary to tuberculosis; but, there is considerable difference of opinion as to the percentage of cases arising from this source. M. Sée claims" that sixty-eight per cent. of all pleurisies are due to this cause. This seems high, or else persons entirely recover from tubercular pleurisy more often than from any other form of tuber- culosis. Dr. G. G. Sears reports” four hundred and fifty cases of pleurisy, thirty-nine per cent. of which developed tubercular disease. Others claim that not more than twenty per cent. of pleurisies are of tubercu- lar origin. Symptomatology.—M. Lanceraux, and other French observers, consider acute pleurisy to be a well-defined cyclical malady,” because its lesions are always found unchangeable, and its evolution is as constant as that of pneumonia or typhoid fever. It may be classified, according to its pathological changes, into three periods of evolution : (1) A period of seven days, at the end of which the effusion reaches the limit of its advance; (2) a period of seven days during which the pathological lesions and the amount of effu- sion appear to remain stationary ; (3) from the fifteenth to the twenty-first day of the disease, during which time an absorption of the inflammatory products, and of the effusion, occurs. Of course these divisions cannot be made absolute, but we may confidently expect, at the end of the first period, in uncomplicated cases, that there will be no further effusion of fluid. Each of these three stages has its respective symptoms, but there is no marked transition from one to the other. In a majority of cases, the first period of acute pleurisy is ushered in with a chill, a more or less marked rise of temperature, and pain in the affected side. 1 Bulletin de L'Académie de Médicine, April 19, 1892. * Boston Medical and Surgical Journal, Feb. 25, 1892. *Bulletin de L'Académie de Médicine, May 3, 1892. A CUTE PLEURISY. 263 The pyrexia will generally determine the intensity of the inflammation ; the temperature seldom rises above 102° or 103°F. unless the pleurisy is secondary to Some other disease. The pain is usually circumscribed, Sharp and lancinating, and is increased on motion, So that the respiratory movements are restrained as far as pos- sible by the patient. A dry, hacking cough is generally present, but the pain it occasions calls for efforts at its suppression. After a few hours, when the effusion ap- pears, the pain moderates, or disappears. The pulse is generally firm, and between 100 and 120. As the disease progresses, dyspnoea is often developed, and is most commonly due to an abundant effusion, to compression of the lung, or to displacement of the heart. Oedema and congestion of the lungs, capillary bron- chitis, and rheumatic difficulties sometimes Occasion dyspnoea when very little fluid can be found in the cavity. Irregularity of the pulse and cyanosis are grave symp- toms, largely dependent on displacement or weakness of the heart. Syncope may, also, be occasioned in various ways. The reflex action of pain is one of its chief causes, as may be shown experimentally by electrifying some peripheral Sensory nerve. Again, when the fluid fills the pleural Cavity, and is suddenly drawn entirely away, the reac- tion which follows may cause syncope. Physical Signs.—On inspection, there is restricted motion of the affected side, dependent in the early Stages on pain, and later, on the accumulated fluid. In left side effusions, there is frequently displacement of the heart beat to the right of the normal line. On palpation, vocal fremitus is lost over the fluid, and, if the effusion be large on the right side, the liver may be felt to be displaced. On percussion, we find, at first, dullness over the lower posterior portions of the chest, then flatness, as the effusion appears and advances. Above the fluid, the 264 JNETW YORK STATE MEDICAL ASSOCIATION. percussion note remains dull, while at its level, and below, it is flat. It will be remembered that the level of the fluid is not a hydrostatic one, but from the elasticity of the lung, the level assumes a shape resembling the letter S. Over the sound lung the vesicular resonance is more or less exaggerated. Dullness is apt to remain for a considerable time after the effusion has been absorbed. On auscultation, the respiratory murmur is enfeebled or absent, for the same reasons and in the same progres- sive manner as the loss of resonance on percussion occurs. Friction sounds are sometimes heard at the beginning of the disease, but are more common at the close of the third stage. - Treatment.—In considering the treatment of acute pleurisy we must recall its aetiological classification into primary and secondary pleurisies. In a recent discussion on the treatment of pleurisy, the eminent French author, M. Hardy," said, that acute pleurisy of sero-fibrous nature was no better treated to- day than it was fifty years ago; and, except in purulent forms, no better results were obtained now than then, the death-rate at present being ten per cent., the same as in the days of our forefathers. This statement may astonish some of us who have been taught to look upon acute pleurisy as a not very fatal disease ; however, some statistics would seem to bear out this opinion. Let us, then, first consider the modern methods of treatment, and later, compare them with those practiced in the early part of this century. The modern medical treatment of acute pleurisy con- sists chiefly in the administration of antiseptics, anti- pyretics, and evacuants. Dr. Charles Talamon” has recently called attention to the action of salicylate of sodium in pleuritic effusions, claiming that it promotes the rapid absorption of the 1 Bulletin de L'Académie de Médicine, May 31, 1892, p. 776. * New York Medical Journal, Jan. 2, 1892. AOUTE! PLEURISY. 265 fluid. He thinks it has a direct action on the inflamed pleura, for Rosenbach has proved by experiment that the salicylates may be found in the serous cavities of the body after their ingestion by the mouth in doses of ten to twenty grains. Whether its beneficial action is due to its antiseptic properties, or to its diuretic action, is still an open question. That Salicylate of sodium may be of use when the pleurisy is secondary to rheumatism there can be no doubt ; but to depend on its success as a germicide in the primary form, would be hazardous. However, the salicylates certainly meet the indications for an antiseptic, antipyretic, and diuretic. The practice of injecting a solution of salicylic acid, or other antiseptic, into the pleural cavity to combat the microbes in the effusion, has been suggested, but the treatment seems harsh and uncalled for, unless employed in connection with surgical methods for the treatment of empyema. Antipyretics in acute pleurisy are only indicated, as such, when the fever rises to 101° or over, and as the fever seldom remains so high for any length of time, their use is quite restricted. Quinine may be advantageously employed in pleurisy depending on malarial poisoning, and as a tonic during Convalescence. Antipyrine, or the other coal-tar derivatives, may be useful in cases accompanied by hyperpyrexia ; but none of these measures are calculated to reach the cause of the disease, or modify its pathology. The evacuants are administered in acute pleurisy with a view to reduce the amount of effusion. Here the diuretics are the most important. Digitalis may support a Weak heart, but its action on the pleuritic effusion is Small. Milk is often used as a diuretic, but is of doubt- ful efficacy, except as a food. Drastic or saline purgatives and sudorifics, not only fail to reduce the quantity of fluid in the chest, but are often dangerous. 266 NEW YORK STATE MEDICAL ASSOCIATION. The chemical composition of ascitic fluid is quite differ- ent from that of the serous effusion of pleurisy; the latter is not simply serum from the blood, but blood plasma. Of late, in the excitement of bacteriological investiga- tions, the profession have been content to disregard the teachings of their ancestors, and the good old methods in vogue at their time. We have regarded these diseases as cyclic in nature; maladies which must run their regular course in spite of all abortive treatment ; sicknesses which are caused by micro-organisms over which we have no control; hence, we must fold our hands and content ourselves with relieving pain until such time as the particular germ has loosened his grasp. This is the ‘‘ expectant treatment” of to-day, and this is the treatment eminent authorities hold out to us for acute pleurisy. - “The expectant treatment,” says M. Peter,” “is the do-nothing treatment, and this is what many bacteri- ologists practice. . . . . No physician has a right to practice inactivity in these cases, when so much can be done towards curing pleurisy if energetic treatment is begun early.” To allow a patient to become weakened by pain and suffering, because pleurisy is a cyclic disease and should terminate spontaneously in two or three weeks; or, be- cause the pathological conditions are such that, by deferring active measures, one may with impunity puncture the chest and draw off a litre of fluid, is treat- ing the wrong end of the disease. A physician should strive to diminish the intensity of a malady, if, indeed, he cannot shorten its duration. What are the indications for treatment in acute pleurisy % Briefly, they are, the relief of pain, the re- duction of fever, and the arrest of effusion; or, in other words, to treat the cause. Our ancestors had a rare knowledge of these indications when they applied bleed- * Bulletin de L'Académie de Médicine, April 26, 1892. AOUTE! PLEURISY. 267 ing and localised vesications, which at once relieved the pain and reduced the fever, and there was little or no serous effusion found in their cases. By these methods the pathological lesions were affected, and the cause of the pain and fever reached. Laennec said, in 1819, “If a plethoric subject had pleurisy, he required bleeding.” While it is undoubt- edly true that the pendulum of exsanguination in inflam- matory diseases oscillated too far in the early part of this century, and to the detriment of many ; is it not also true that, at the present time, it has swung too far the other way, and “expectant treatment” is employed to the detriment of many ? I believe the antiphlogistic treatment is indicated now in just as many cases of acute pleurisy, as in the days of Our forefathers. That the treatment may be carried too far, I do not deny ; the judicious use of it at the right time is the essential point. Pain is quickly relieved by the revul- sive methods; probably by the removal of the congestion and its baneful influences. At the present time, Opium, in Some form, is employed for the relief of pain; but does it lessen the congestion causing the pain, or simply dull the sensibility to pain' - Revulsives and antipyretics both lower the fever, but Will the antipyretic drugs alter the pathological condition Within the pleural cavity ? Farther on in this disease we often employ puncture of the chest to draw off the fluid ; but, have we not allowed the malady to reach that point by neglecting at the beginning to treat the cause efficiently M. Peter goes so far as to say “that by revulsive methods, early employed, one is able to prevent the serous effusion in many cases; to arrest it, if the secre- tion has begun to form ; and, finally, to absorb it, if a small amount has collected.” Andral and Bouilland” Cite thirty cases, in one year, treated antiphlogistically, * Bulletin de L'Académie de Médicine, April 26, 1892. 8 Ibid. 268 NEW YORK STATE MEDICAL ASSOCIATION. with one death, a mortality of three per cent. Of seventy cases reported" in 1891, treated after the modern methods, there were seven deaths, a death rate of ten per cent. from acute pleurisy. How should revulsion be employed in these cases 2 Bouilland used to bleed twice, and afterwards apply wet cups and a large blister. One might employ wet cups and vesication more mildly, with equal success. M. Peter” says: “What is remarkable in these cases is the toleration of the system to these large bleedings ; the rapidity with which the pain ceases, and the local symptoms of pleurisy diminish.” On the other hand, M. Sée” says: “Bleeding, after doing so much harm, is springing up again insidiously in many diseases ; it has no theoretical basis, and is little better than empiricism.” Can we learn anything from nature as to the treat- ment of acute pleurisy % The inflammatory process irritates the intercostal nerves, and causes pain; but in consequence of this inflammatory action, evolves a fluid which acts as a sedative to the injured nerves, and little by little the pain subsides. As this fluid closely resem- bles the plasma of the blood, is it not fair to assume that nature bleeds her patient in the early stage of pleurisy % It is generally held that blisters are useful adjuvants to scarification, but some believe that cantharides pre- dispose to the transformation of serous effusions into purulent ones, especially in tuberculous patients. There is no positive way to identify purulent pleurisies from the serous variety except by explorative puncture, but the indiscriminate use of the exploring needle—ten or a dozen times, as recommended by some *—is to be condemned. * Bulletin de L'Académie de Médicine, April 26, 1892. 8 Ibid. * Bulletin de L'Académie de Médicine, April 19, 1892, p. 597. *Archives of Pediatrics, May, 1892, p. 353. AOUTE! PLEURISY. 269 Thoracentesis.--This operation, though always to be deplored, is often urgently demanded. That aspiration, as first practiced by Bowditch, and later, elaborated by Dieulafoy and others, is a simple and harmless operation, there can be no doubt ; but as practiced by the majority of general practitioners, with no special attention to the cleanliness of trocar or aspirator, it is a very dangerous operation. All that is essential to the safety of the operation is thoroughly aseptic instruments, especially the aspirating needle, and some little skill in manipulation. It has been held by some that after the operation has been performed two or three times, a sero-fibrous effu- sion becomes a purulent one. This may be SO. I do not deny that it often happens, but it is rather the fault of the operator and his unclean instruments. As a rule, aspiration should not be performed in simple sero-fibrous pleurisy until after the third week of the disease, and then only as the fluid tends to remain stationary and unabsorbed, unless there is urgent need of interference to save life. If the cause of the non-absorption of the fluid is, as Suggested by M. Lanceraux, a stoppage of the lym- phatics of the pleura by the formation of fibrous thrombi in their orifices, we must wait until a disintegration of the clot takes place before the fluid will be absorbed, and no amount of aspiration will hasten the process of natural absorption until that time has expired. This period of disintegration is about the twenty-first day of the disease. However, there are times previous to this period, when life is threatened by the accumulation of fluid in the pleural cavity to such an extent as to com- press vital organs, When this occurs, it becomes necessary to draw off a Certain amount of fluid by aspiration, in order to relieve the distressing symptoms. When the fluid has accumulated, has progressed to Such an extent that there is dyspnoea, more or less 270 NEW YORK STATE MEDICAL ASSOCIATION. cyanosis, flatness on percussion over most of the affected side, sometimes associated with bulging of the inter- costal spaces, the patient is already in great danger. There is no infallible guide to the best time for operating in these cases, but percussion furnishes the most reliable test, for by it we may arrive at an approximate estimate of the quantity of fluid contained in the pleural cavity. When the line of flatness has reached the second rib on either side the chest, Dieulafoy estimates the quantity to be about 2,000 grammes, and states that it is time to operate. If, with this, there is dyspnoea and some cyanosis, the operation should be immediately per- formed. If, as often happens after the early operative interfer- ence, the fluid should re-accumulate, and the distressing symptoms return, a second Operation would be impera- tive, and probably later on, others would follow. Only so much of the fluid should be removed in these cases as will render the patient more comfortable, or remove any danger of immediate collapse. The removal of the entire amount of effusion at Once has caused Sud- den death, due to the congestion produced by the sudden return of the compressed and distorted lung to its normal position. Therefore, the fluid should be withdrawn gradually through a fine needle, and not more than a third, or perhaps a half of the total quantity of fluid in the chest cavity removed at once. It is better to perform the operation several times in this manner than to have a fatal issue from the evacua- tion of too great a quantity at once. In purulent pleurisies, no time should be lost in evacu- ating the pus, observing the same precautions necessary, if by aspiration, as in serous effusions. In children with purulent pleurisies, repeated aspirations are advisable before resorting to more severe surgical methods; but in adults, if a re-accumulation of pus occurs after One aspiration, it is usually better to treat the empyema AO: UTE! PLEURISY. 271 as one would an abscess cavity, and establish free drainage. Finally, I wish here to suggest a method of treatment of pleuritic effusions, which I must frankly state is at present only a theory. I refer to the employment of electrolysis to cause absorption of pleuritic effusions, just as it is used in the treatment of serous effusions elsewhere. The operation might be appropriately called “electrocentesis.” I have not found any literature on the subject, but we know electrolysis has been employed quite commonly in Other serous effusions, such as hydroceles or other cystic tumors with great benefit, in many instances, and why should it not be equally beneficial in the serous effusion of pleurisy % Electricity hastens the absorption of fluid in cysts; first, by its power to transform the watery elements into gases, and secondly, by its direct stimulating effect on the lining membrane of the sac. Is there any reason to expect a different result from a similar use of electricity in pleuritic effusions? The technique of the operation would consist in thrust- ing an electro-puncture needle into the effusion, applying to the chest wall a clay electrode attached to the negative pole of a galvanic battery, and in using a current strength Of thirty to fifty milliamperes. Care should be taken that the needle be not thrust farther than just into the fluid, so that we get only an action on the effusion and the costal pleura; otherwise We might electrify some vital organ with very unpleasant results. From this application of electrolysis, we might reason- ably expect more or less coagulation of fibrinous matter, and absorption of the fluid portions of the effusion, in proportion to the strength of the current, and the length of time the current is allowed to pass. This method of treatment would probably benefit those Cases in which thoracentesis for any reason could not 272 NEW YORK STATE MEDICAL ASSOCIATION. safely be performed, those in which there had been repeated re-accumulation of fluid after aspiration, and, finally, those of secondary nature, particulary those of a tuberculous character. All the usual antiseptic precau- tions should, of course, be observed. DISCUSSION. DR. F. W. HIGGINs, of Cortland county, said that in not a single case which had come under his observation had he considered there was an in- dication for venesection. This practice was theoretically good in strong and robust people, but in the cases he had seen, the onset of the disease had usually been insidious and without much pain; in Short they were not of the sthenic type. He had been interested in the theory propounded in the paper, that there must be some systemic cause not yet discovered, and he was encouraged to believe that investigations in this direction would yield good practical results. DR. H. D. DIDAMA, of Onondago county, said that he had heard nothing in the paper which had made him change the views which he had expressed on the previous evening in favor of early aspiration in pleurisy. Why not draw off the fluid when the acute symptoms subside, instead of waiting from two to six weeks 2 Those who practice late aspiration are the ones who have chronic cases of pleurisy, with carnification of the lung, in many instances; and if the lung be much compressed, the other lung must do the work, and this will lead to congestion and much subsequent trouble. By early and complete aspiration, the lung is permitted to expand immediately, and it is not necessary, as in the later operation, to use a very fine needle for fear of producing severe symptoms. It was long ago ascertained that diuretics, and diaphoretics, and cathartics, and blisters are not useful in pleurisy, and yet these remedies are used still by many. Tonic treatment from the start should be the rule; it is only occasionally that sthenic cases are met with. Anstie recommended the administration of the tincture of the chloride of iron in all cases from the beginning, and he found that he had much better results from this treat- ment than by the use of antiphlogistics. Strapping is a good treatment after awhile, but anodynes, antipyretics, or other depressants are not needed. DR. JoHN CRONYN, of Erie county, indorsed all that had been said by the preceding speaker. Plethoric individuals might be benefited by bleeding, and the asthenic by cupping. When he was eighteen years of age, he had pleurisy, and as venesection was then in vogue, he was bled, and after- wards thirty leeches and a blister were applied ; yet in spite of all this, he still lived and enjoyed good health. In the early years of his practice, when he bled freely, and gave large doses of opium with calomel, he had DISCUSSION. 273 scarcely any trouble with his cases of pleurisy, and he still held that as soon as there is evidence of the subsidence of the acute inflammation, the fluid should be removed, otherwise it would probably lead to a tubercular, or at least to a chronic pleurisy. DR. N. B. SIZER, of King's county, recalled a case in which he had performed venesection at the Roosevelt Hospital. A man who had been working for several hours in ice-cold water, suddenly began to shiver; his temperature rose rapidly, and within a few hours he was delirious and suffering from dyspnoea and severe pain in his chest. On admission to the hospital, there were the usual signs of beginning pleurisy on each side, and he was actively delirious. Venesection was performed, and all the symp- toms promptly subsided, and he was discharged from the hospital on the fifth day. THE PRESIDENT remarked that the author's idea of promoting absorption by the use of electricity was novel to him, and he hoped to hear in the future a report on this method of treatment. 18 A CITNICO_PATHOLOGICAL STUDY OF INJURIES OF THE HEAD, WITII SPECIAL REFERENCE TO LESIONS OF THE BRAIN SUBSTANCE. By CHARLEs PHELPs, M. D., of New York County. Movember 16, 1892. Two years ago I read before this association, in the course of a general discussion upon cerebral surgery, a very brief paper upon cerebral contusions. Since that time a very considerable number of cases of serious in- juries of the head, almost all of which have involved lesion of the brain substance, have come under my ob- servation. They present so many points of interest and importance that I have ventured to ask renewed atten- tion to an extension of the same subject. In no depart- ment of surgery are more problems yet unsolved, and in no department are the results of careful study likely to be of more absorbing interest or of greater professional value. Attention has been largely directed to cerebral localisa- tion, and to certain surgical procedures founded upon the indications it has afforded. Such operations upon the brain have been conspicuously successful, and have been justly reckoned among the triumphs of modern Surgery. When guided by the disclosures of physiological experi- ment and aided by the application of recognised aseptic laws, operations upon the brain have been devised and Successfully executed, which in the immediate past would have been not only impossible but incredible. It is equally true that these operations are still limited in number and application. The instances in which brain lesions can be accurately defined and located, and after- &TUDY OF INJURIES OF THE HEAD. 275 ward made subject of operation with reasonable prospect of success, are comparatively infrequent. The lesions which are of such nature, so well defined in outline, or so situated, in view of demonstrated localisation of brain function, that their diagnosis can be made with reason- able certainty, are few enough in the first instance ; those which are within reach of the surgeon’s knife are fewer still ; and those in which the patient ultimately survives constitute but a small proportion of the origin- ally scanty number. It is not strange, however, that operations which invade the very penetralia of the human organism should fascinate by their audacity, and that, when successful, they should dazzle the modest workers in more prosaic fields of labor. It is also possible that the ardor with which the diagnosis and relief of local leisons of the brain have been pursued, in the light of functional localisation, may tend to distract attention from those general pathological conditions which are of So much greater frequency. The study of cerebral topog- raphy, moreover, has been so much more effectively prosecuted by the physiologist than by the pathologist, that perhaps the results of clinical and pathological Work have been practically if not theoretically under- rated. It is certainly proper at the present time to more generously supplement physiological experimentation by both ante-mortem and post-mortem observations made upon the human subject. For this purpose, cerebral traumatism, which this series of cases illustrates, affords peculiar advantages, since death results from the estab- lishment of lesions in a previously healthy brain, and Since it presents itself with sufficient frequency for pur- poses of comparison. The cases which I propose to subject to analysis are one hundred and twenty-four in number, and, with two or three exceptions, have been previously unreported. They have occurred mainly in my service in two hospi- tals, and in the last two years. They include all cases of *Juries of the head which I have seen during the time 76 AVEW YORK STATE MEDICAL ASSOCIATION. Specified, and if they are preponderatingly of one charac- ter, they are probably still representative of the whole class to which they belong. Wounds of the scalp have not been included, because they are not only surgically insignificant, but have no necessary relation to the deeper- Seated injuries which it is proposed to consider. In a previous paper upon a subject of an entirely different character, I found it convenient to abstract the histories. of the Several cases upon which it was based. I pursue the same course in the present instance in order to afford a means of verification of such conclusions and general- isations as I may establish, and at the same time to make record of a large amount of material which may be of Service hereafter to students of the same class of injuries. I shall not attempt a reading of these histories, but shall leave them to appear in the archives of the Association for future consultation. They are arranged in accord- ance with the nature and result of the primary injury. FRACTURES AT THE BASE. CASE I. Male, forty-five years of age ; fell in the street ; admitted to alcoholic ward; wild delirium, requiring mechanical restraint; haemor- rhage from left ear; wound in posterior parietal region ; high temperature ; coma; death in forty-eight hours. Necropsy.—Fracture at the base, with complete separation of the left temporal bone into its constituent parts—squamous, petrous, and mastoid. Slight laceration of left parietal lobe at a point corresponding to seat of external injury. At a corresponding point upon opposite parietal lobe there was extensive laceration 3% x 1% inches in diameter. CASE II. Male, forty years of age; said to have fallen from his truck; no superficial injury; delirium, which was considered alcoholic; refused treatment; delirium continued next day, and he committed suicide by drowning. Necropsy.—Fracture at base extending from left parietal eminence to foramen magnum. Superficial laceration of right temporo-sphenoidal lobe by contre-coup. These two cases have been previously reported. CASE III. Male, fifty years of age; fell from steps to sidewalk; scalp wound in right posterior superior parietal region; haemorrhage from right ear, and later from right nostril; coma; stertor; rigidity of all the limbs ;. left pupil dilated. In twelve hours complete left hemiplegia supervened, STUDY OF INJURIES OF THE HEAD. 277 and haemorrhage from right ear renewed. Stertor and rigidity disappeared, and left pupil became normal. Unconsciousness and incontinence of urine continued from time of admission till death from asthenia at the end of six days. Mecropsy.—Fracture at base, beginning at point of injury and extending through right petrous portion and middle fossa to apex of opposite petrous. Lacerations of left frontal and right temporo-sphenoidal lobes inferiorly and laterally. Thick clot over left frontal and temporal lobes laterally, growing thinner as it extended toward base and vertex. Whole brain intensely hyperaemic. - CASE IV. Male, twenty-two years of age; cause of injury unknown ; compound depressed fracture external to right parietal eminence; semi- comatose, irrational, articulation indistinct ; respiration continued slow and irregular for three days. The depression was found on trephining to be of the external table only. Two days after admission, complete paralysis of extensors of right hand, paresis of right arm, and right facial paralysis, involving both mouth and eyelid. All these paralyses afterward varied in degree from time to time, and the mental condition varied from rationality to noisy delirium. He was usually restless, and became un- conscious for two days before death. Temperature on admission, 101°, and remained above 100° for a week. Then declined to 99°–– during another week. Two days before death it rose steadily from 103° to 109°. Died in forty-five days. Necropsy.—Fissure extending from point of depression into right middle fossa. Subacute arachnitis and excessive cerebral hyperaemia; Surface of brain at point of fracture unchanged, but beneath it was a large cavity containing reddish semi-fluid material, and brown detritus from Subcortical laceration. CASE W. Male, thirty-five years of age; cause of injury unknown ; Scalp wound over occipital protuberance ; patient under influence of drink; Would not answer questions; grew stupid, and in three hours became unconscious ; mechanical restraint necessary. Temperature soon after admission was 102°, and in ten hours became 105°, receded to 101.8°, and then rose steadily to 106.6°. He died twenty-nine hours after admission. Necropsy.—Haematoma covered whole calvarium. No fracture of ver- tex, but a slight fissure existed along the posterior border of the right petrous portion of temporal bone from contre-coup. Thin coagulum and fluid blood covered upper surface of both cerebra (meningeal contusion). Lacerations of under surface of left frontal (large) and temporo-sphenoidal, of inner border of right frontal, and of under surface of right temporo- Sphenoidal lobes. The last was as large as a hickory nut. CASE WI. Male, thirty-eight years of age; knocked down by a blow upon the head from a club ; scalp wound in right parietal region. He was stupid, and could not answer questions coherently. Left pupil slightly dilated and eyes directed slightly to the right. Next day incoherent, delirious, and had delusions and muscular tremor, pupils irregular, pulse 2.78. NEW YORK STATE MEDICAL ASSOCIATION, frequent and intermittent. Temperature on admission 108°, five hours, later 102°, rose to 106.2°. Died in twenty-four hours. Mecropsy.—Linear fracture through whole length of right parietal, right occipital, and petrous portion of temporal bone into middle fossa. Consider- able laceration of under surface of left frontal and temporo-sphenoidal lobes. CASE VII. Male, forty-five years of age ; fell upon the sidewalk, striking the back of the head. Admitted after twenty-four hours. Oedema under and about an old cicatrix behind the right ear, and underneath this. an extensive comminuted fracture. Two pieces of bone were removed and one elevated, and a large, firm epidural clot extracted as far as possible. The patient was in a condition of stupor; pupils irregularly dilated ; artic- ulation difficult; muscles generally rigid ; gait ataxic when he attempted to walk; sensibility diminished, and urine incontinent. His condition improved for four days after operation ; temperature decreased, mental condition became clearer, and muscular rigidity lessened. There was copious serous discharge from the right ear, followed by right facial paral- ysis. On the fifth day temperature rose from normal, muscular rigidity again increased, and he again became stupid. The next day he became unconscious, and in an hour's time he had eighteen general convulsions, and died the following morning. His temperature did not exceed 98.8° ill the fifth day. On the morning of his death it was 105°. Mecropsy.—Fracture at the base. The whole central portion of the occipital, from the foramen magnum upward, and posterior portion of both parietal and right temporal bones, forming an irregular circle two inches and a half to three inches in diameter, were broken into large frag- ments, two of which had been removed during life. The mastoid and outer part of the petrous portion of the right temporal bone could be re- moved by the fingers with the use of very little force. This line of frac- ture ran through the tympanic cavity, so that, after removal of the outer fragment, the carotid canal and aqueductus Fallopii could be seen in the section filled with coagula. A large epidural clot was situated beneath the occipital fracture, extending half an inch beyond its margin. A large sub- dural clot filled the right inferior occipital fossa, extending, to the foramen magnum. The cavity of the posterior part of the great longitudinal sinus. was occupied by a thrombus, and its walls were infiltrated with blood. There was a large, partially decomposed thrombus in the torcular Her- ophili, extending through the right lateral into the petrosal sinus and inter- nal jugular vein. The whole internal surface of the dura beneath the seat. of the external haemorrhage was lined by a firmly coagulated clot, with an inflammatory exudation around it. A portion of the surface of the right occipital lobe posteriorly was softened, showed minute haemorrhages, and was torn away in the removal of the dura. The meshes of the pia mater over a large part of the parietal and occipital lobes posteriorly Were distended with slightly turbid serum. There was a small laceration on the under surface of each frontal lobe, and a larger one, three-quarters of an inch in diameter, existed in the right cerebellum at a point corresponding to the site of the thickest part of the subdural haemorrhage. STUDY OF INJURIES OF THE HEAD. 279 CASE VIII. Male, seventy-six years of age; cause of injury unknown ; admitted to alcoholic ward, and transferred to surgical service same day. Patient unconscious from the time he was found in the street. Stertor; muscles rigid on both sides; both pupils very strongly contracted, the left one the more so. Scalp oedematous in right parietal region. Fissure, extending from posterior and inferior part of right parietal into occipital bone, discovered by incision. There was no change in the general symp- toms up to the time of death, two days and six hours after admission. The left pupil continued to be the more strongly contracted, and muscular rigidity more strongly marked on the right side. Consciousness was not regained. Temperature on admission, 100:4°; rose steadily to 103-8°; post-mortem, 102°. Necropsy.—Fracture at base extended to right jugular foramen, and then turned backward to foramen magnum. Slight epidural and consid- erable subdural haemorrhage at point where fracture began. Slight Serous effusions into pia. Thrombus in torcular Herophili, extending into right occipital sinus and through petrosal sinus into jugular vein. The whole inferior surface of the brain covered with blood. Superficial laceration along the anterior border of left temporo-sphenoidal lobe from median line outward. Large clot could be seen bulging outward, behind a thin corti- cal layer, along the whole length of external border of left frontal lobe. Well-marked lacerations upon anterior border of both frontal lobes, and also upon their inferior surfaces along the longitudinal fissure. Optic Chiasm surrounded by a clot, which extended backward as far as anterior border of the pons Warolii. Upon section along external border of left frontal lobe, a clot of great size was disclosed, which occupied almost the Whole substance of the left frontal and temporo-sphenoidal lobes, from the third frontal convolution backward. This haemorrhage had broken through into the lateral ventricles and thence into the occipital lobes, which were also filled with great pools of fluid blood. CASE IX. Male, forty years of age; fell into the hold of a vessel; Semi-conscious when found; haemorrhage from both nostrils and from right ear; regained consciousness next day; four days later, delirious and irritable; back of neck rigid ; abdomen retracted. Cheyne-Stokes respira- tion supervened. Temperature for seventy-two hours, 99-2° to 99.8°; fourth day, 103.2°; fifth day, 104.8°. Death at end of five days. Mecropsy.—Contusion over right mastoid revealed on raising the scalp. Fracture at base in three fissures; extending from this point, two (fine) *Cross petrous portion, and a third connecting them posteriorly across occipital bone. Deep linear laceration, extending across inferior surface of right cerebellum, near outer border. Subdural haemorrhage over whole left Serebrum, superiorly and laterally; most copious in middle lateral region. Laceration of antero-inferior border of left frontal lobe. White substance of left cerebrum much congested, and with punctate extravasations throughout its extent. * CASE X. Female, eight years of age; fell two stories; partially uncon- *8; left hemiplegia, and haemorrhage from left nostril; depressed 280 NEW YORK STATE MEDICAL ASSOCIATION. fracture over left frontal eminence. Patient became irritable, and the bone was elevated an hour later. Died within twenty-four hours. Necropsy.—Coronal suture separated on the right side. A fissure ex- tended through right parietal eminence and another through frontal bone. Base fractured across body of sphenoid into left middle fossa. Other fissures through right middle and anterior fossae, external to orbital plate. Epidural haemorrhage on left side anteriorly and in temporal region. Lacerations in right frontal lobe and in right fissure of Rolando, and in left temporo-sphenoidal lobe. CASE XI. Male, twenty-nine years of age; fell fifteen feet into the hold of a vessel and struck on his head. Coma, stertor; left pupil markedly dilated and right pupil contracted; paraplegia, haemorrhage from left ear and nose and under left conjunctiva, and contusion over left eye. Died in five minutes after admission. - Necropsy.—Epidural haemorrhage, blood still fluid. Fracture extend- ing downward and forward from behind left parietal eminence, across petrous portion, through middle fossa, transversely across anterior fossa, and terminating at inner extremity of lesser wing of right sphenoid. Slight cortical haemorrhage on left side, and slight lacerations of under Sur- face of left frontal and temporo-sphenoidal lobes. CASE XII. Female, twenty-three years of age ; jumped from fifth story window. Contusions of left hip and shoulder and over right parietal eminence; slight haemorrhage from nose and left ear; temperature, 99.4°; incontinence of urine and faeces; right hemiplegia. Death in two days. Mecropsy.—Fracture extending from right parietal eminence to foramen magnum, of right petrous portion entire length, and of left petrous for two inches; laceration of left parietal lobe beneath parietal eminence. CASE XIII. Male, forty-six years of age ; fell five stories. Coma, stertor, pupils normal; pulse and respiration normal. Death in five days. Necropsy.—Contusion over right parietal eminence; fracture extending from this point downward and forward, anterior to petrous portion, and through sella turcica; subarachnoid haemorrhage over both hemispheres laceration of under surface of left temporo-sphenoidal lobe. CASE XIV. Male, fifty years of age; knocked down by a blow in the face and fell upon the back of his head. Patient became unconscious, but shortly afterward walked to the hospital; contusion over right parietal eminence; dazed; no other symptoms; walked home ; had severe pain in the head for three hours after the injury, then became gradually uncon- scious till four hours later, when coma was complete, and death occurred at the end of another hour. Necropsy.—Wound of lip and contusion of forehead; very fine fissure of external table, beginning in right inferior occipital fossa and running across right petrous portion; slight epidural haemorrhage about the middle of the fracture; upon left side, large subdural extravasation upon lateral border of parietal and frontal lobes, extending upward and also downward into middle fossa; also some extravasation into pia and several slight STUDY OF INJURIES OF THE HEA. D. 281 contusions of brain substance ; skull thin, and angles and processes upon its inner surface unusually sharp and prominent. CASE XV. Male, forty years of age ; cause of injury unknown. Coma ; respiration slow and full ; right pupil dilated, left contracted ; re- flexes lost; had been seen to move the left side ; pulse became slower and breathing more labored. Died in nine hours and a half. AWecropsy.—Contusion in left parietal region; fracture from this point extending by two fissures into anterior and middle fossae ; large epidural haemorrhage from rupture of left middle meningeal artery ; slight lacera- tion of left parietal lobe at point where fracture began, and another upon lateral border of right temporo-sphenoidal lobe. CASE XVI. Male, fifty-five years of age ; fell upon the street. Uncon- scious; respiration labored; left pupil slightly dilated; slight haemorrhage from left ear; slight rigidity of left side. He was still stupid upon admis- sion, but could give his name. Temperatue, 99°. Dilatation of left pupil and rigidity of left side increased, and afterward there was complete par- alysis of left lower extremity, while left arm remained slightly rigid ; left hemiplegia was finally complete. He died in twenty-one hours. Temper- :ature, 101°2°. Necropsy.—Contusion of scalp over left occipito-parietal suture; skull thin ; stellate fracture, originating about the centre of left parietal bone; fissures extending upward, across base of occipital and along the upper border of petrous portion of temporal bone into the middle fossa; sub- dural haemorrhage covered right hemisphere ; under and lateral surfaces of right temporo-sphenoidal lobe extensively lacerated; under surface of both frontal lobes lacerated along the median fissure; these lacerations were recent. Upon the under surface of the left temporo-sphenoidal lobe there Was a deep laceration, irregular in outline, but about an inch in its several diameters; there were also small and deep lacerations upon its anterior border and upon the under surface of the left frontal lobe. All these lacerations upon the left side extended through the cortex, contained no recent clot, but were covered with a grayish-yellow viscid substance, and Were bounded by a considerable area of yellow softening. They evidently antedated the final and fatal injury. Section of the brain disclosed marked hyperaemia. CASE XVII. Male, fifty years of age; cause of injury unknown. Un- 90nscious; pulse, 66; respiration full and slow ; right pupil dilated, the left contracted, neither one responding to light ; he had been seen to move º: left side of the body; stertor supervened, and death occurred in eleven Tholl|rS. Wecropsy.—Contusion of left parietal region disclosed by incision ; two fissures originated from this point, one extending into the anterior and the other into the posterior fossa; large epidural clot from rupture of left middle meningeal artery; general contusion; hyperaemia. Case XVIII. Male, thirteen years of age; fell two stories. Haemorrhage from right ear; unconscious; irritable when disturbed ; consciousness 282 NEW YORK STATE MEDICAL ASSOCIATION. regained in thirty minutes; pulse 78, intermittent; temperature, 98°; de- pressed fractures below right temporal ridge; elevated next day; three fissures, one backward, one forward, and one downward ; dura incised ; only subarachnoid haemorrhage; temperature, 101-8°. Next day patient irritable and somnolent ; urine incontinent; temperature slightly increased (102°). On second day after operation he was delirious, and temperature rose steadily till evening, when it was 105'4°. On the third day the skin was hot, and he was very restless and sensitive to external impressions; his pupils were moderately dilated and reacted slowly. From this time he was in deep coma; temperature varied from 104°-H in the morning to 105°–H in the evening till death occurred on the evening of the Seventh day, when it was 106'5°. Necropsy.—Skull thin. No pus in the wound or in the small brain cavity which had been disclosed by the ante-mortem operation when the depressed bone was elevated. Subdural haemorrhage in the opposite (left). occipito-parietal region. An effusion of thick green pus beneath the arachnoid covered the lateral and superior surfaces of the right occipital and parietal lobes, but did not extend forward to within an inch of the cranial opening left by the ante-mortem operation. A subdural effusion of similar thick green pus was co-extensive with the whole right inferior occipital fossa. There was a deep laceration, an inch in diameter, upon the lateral border of the left temporo-sphenoidal lobe, which involved the subcortical tissue. At a point directly beneath the opening left by the removal of the depressed bone, there was a cavity in the brain substance as large as a hickory nut, which opened by its whole extent upon the cerebral surface. As this surface was intact at time of operation, the cavity must be ascribed to a direct subcortical contusion, not involving the superficial laceration, and to a subsequent giving way of the cerebral cortex under the influence of arterial pulsation, and in the absence of the normal repressive force exerted by the skull and dura. The whole brain substance and meningeal vessels were intensely hyperaemic, and there were numerous minute extravasations from general contusion. There was no meningeal or ventricular serous effusion. A fissure extended from the central point of fracture through the petrous portion of the temporal and inferior occipital fossa to the foramen magnum. CASE XIX. Male, nineteen years of age; fell three stories through a hatchway ; unconscious; irritable when disturbed ; pulse, 80; tempera- ture, 100°; profuse haemorrhage from left ear, which continued twenty- four hours, and was then followed by serous discharge. At the end of twenty-four hours patient was still unconscious, pupils were largely dilated and movable, and he had general convulsive movements, most marked in the right leg. During the second day coma was more profound and gen- eral convulsive movements ceased, but he had one prolonged general convulsion, which was repeated on the third day, the movements being most violent on the left side. The left pupil continued from the first day to be more contracted than the right. Died in three days and six hours. Temperature continued to rise from time of admission, and reached 107'2". STUDY OF INJURIES OF THE HEAD. 283 Necropsy.—Large haematoma in substance of left temporal muscle. Fracture extended from left squamous portion of temporal bone into mid- dle fossa, and by a wide fissure along the anterior border of the petrous portion to the sella turcica. Large epidural and subdural clots in left middle fossa, Right cerebrum covered by a thin subdural coagulum. In the left middle fossa diffuent brain substance clung to the dura as it was removed. Large and deep laceration of the lateral border of the left tem- poro-sphenoidal lobe and of the lateral border and contiguous inferior surface of the right temporo-sphenoidal lobe. Small and deep laceration at junction of right parietal and occipital lobes. All these lacerations extended into the subcortical tissue. CASE XX. Male, sixty-two years of age ; cause of injury unknown ; found unconscious in an ice-wagon with his head lying on a cake of ice. Contusion of left parietal region, and both eyes much ecchymosed. Sub- conjunctival haemorrhage at outer part of left eye. Muttered incoherently when disturbed. Slight temporary rigidity of right arm. Testless and irritable all day, and roused sufficiently in the evening to give a name and address, both of which proved to be incorrect. Condition underwent little change till death—at the end of seven days and seven hours. Temperature high on admission — 100°; in forty-eight hours, 104.8°; seventy-eight bours later it receded to 101:2°; in forty-eight hours more it varied from 101° to 102°-H, and then rose steadily to 107°–H at the time of death. Necropsy.—Skull thin ; fracture of left anterior and middle fossae, ap- parently beginning with a comminution of orbital plate of left frontal bone about its centre. At this point two or three small fragments were dis- placed upward with fine divergent fissures. One fissure ran outward and upward into left squamous portion of temporal bone; another ran back- Ward from the crista galli through the bodies of the ethmoid and sphenoid, through the optic foramen and along the anterior border of the petrous portion; and the third ran through the right optic foramen into the Squamous portion of the right temporal. The optic nerves were uninjured. There was a little blood extravasated over right occipital and lower part of right parietal lobes. The left frontal lobe was completely excavated by a laceration which was bounded everywhere by a thin layer of unaltered Cortex, except inferiorly, near the anterior border, where it was covered in only by the meninges. It was separated from the ventricle by a thin Septum of brain substance. This cavity contained commingled blood, clot and brain detritus. There was also a laceration of the anterior two- thirds of the external lateral border of the right cerebellum, and an extrav- agation the size of a robin-shot existed in the centre of the right corpus striatum. There was no clot anywhere at the base of the brain, and no further lesions. CASE XXI. Male, twenty-seven years of age; fell seventeen feet into the hold of a Vessel, striking his face and stomach. Thirty minutes later an Officer found him lying upon the dock, unconscious and bleeding from * mouth and nose. In the interval which had elapsed he was said to 284 NEW YORK STATE MEDICAL ASSOCIATION. have been excited and abusive. He was seen upon the dock, and twice afterward during the night at the station-house, by ambulance surgeons, who refused to take him to a hospital, because, in their opinion, he was simply drunk and in no want of surgical treatment. The next morning he was taken to court by two policemen. He was then conscious, and, in their inexpert opinion, rational. He was unable to stand or walk, and was carried between them on their arms into a street-car and into court. He was duly sentenced for intoxication, but by an inspiration of somebody he was halted on his way to the Island, and placed in the alcoholic ward at Bellevue. A little later he was transferred to a surgical ward. At that time he was weak, his pulse slow, and respiration labored. There was much ecchymosis of the eyes, and the lids could be separated only with great difficulty. There was subconjunctival haemorrhage of both eyes, and the arms were rigid, more especially the right. Pupils normal. The patient soon grew restless, and had muttering delirium, incontinence of urine, and Cheyne-Stokes respiration. Temperature, 1048°. Depressed fracture easily felt in right frontal bone. The same afternoon he was trephined, and the fracture found to be stellate, with a depression an inch by half an inch in diameter. The inner table was driven through the dura. Pulse and respiration temporarily improved, but he grew weaker, and died eight hours after admission to the ward. Temperature, 106°. Necropsy.—I am indebted to the report of Dr. W. T. Jenkins, late of the coroner's office. There was a linear fracture in the temporal bone, three inches long, extending upward and backward from the anterior margin. There was a stellate fracture in the frontal bone to the right of the median line and an inch above the superciliary ridge. On the inner surface of the skull the fracture extended across both orbital plates, through the ethmoid and body of the sphenoid bone, and on both sides through the anterior fossa and through the left middle fossa nearly to the petrous portion of the temporal bone. The nasal bones were also fractured. These fractures were nearly all comminuted. There was no considerable haemorrhage in the cranial cavity. The upper surfaces of both hemispheres were lacerated, especially at seat of fracture. CASE XXII. Male, thirty-nine years of age ; fell from mizzen-top to deck, and struck upon right temporal region; admitted half an hour later; unconscious, and bleeding from right ear; stertorous breathing; pulse full and bounding; lacerated wound in right parietal region. He had pulmo- nary oedema, for which he had already been bled from the arm by the ship's surgeon. Died in two hours. Necropsy.—Haematoma over whole right side of the head. Six multiple fissures of the base involving both sides and all the fossae. The primary fissure, of five which were connected, began as a wide fissure behind and a little to the left of the foramen magnum, and narrowed to a hair's breadth as it ran forward to the right superciliary ridge. A sixth, and entirely independent fissure, ran backward from the crista galli on the left side through the optic foramen to the sella turcica. There were slight lacera- tions of the under surface of both frontal and right temporo-sphenoidal STUDY OF INJURIES OF THE HEAD. 285. lobes, which occasioned slight Subdural haemorrhage. On the upper and ateral surfaces of the hemispheres, especially the left ; and at the base, an epidural haemorrhage of larger size existed in the inferior occipital fossae, land pressed upon the pons and medulla. CASE XXIII. Male, forty years of age ; found at foot of cellar stairs, unconscious and restless, with a large lacerated scalp wound, which had bled freely, and with several wounds of the face. When admitted to the alco- holic ward on the diagnosis of ambulance surgeon of another hospital, was still unconscious. The Scalp wound was in the parieto-occipital region, to right of median line, and the most extensive face wound was over the right malar bone. As he did not “clear up,” he was transferred to a surgical ward four days afterward. He was then nearly comatose, quiet unless dis- turbed, his pupils normal, and respiration slow and regular. Temperature, 102.2°; pulse, 96. Temperature next day was 104.6°, 103.6°, and 106°; and on the morning after it was 105° and 107°, when he died without further symptoms, five days and a half after reception of injury. Necropsy.—Fracture at base, through petrous portion of left temporal bone, extending to foramen magnum. Laceration of left temporal and frontal lobes, with cortical haemorrhage. CASE XXIV. Female, thirty-eight years of age; habitual criminal; jumped from the third tier of the Tombs Prison to the flagging below, thirty feet or more ; punctured wound in left occipito-parietal region; un- conscious; haemorrhage from left ear; pupils moderately dilated, more especially the left ; and vomiting persistent. Temperature, 98.9°. The next morning the patient was conscious, rational, and the haemorrhage had nearly ceased. In the evening she was slightly delirious, and the follow- ing day required mechanical restraint till quieted by sedatives. Both pupils became widely dilated, the left still continuing more dilated than the right, and they were only slightly responsive to strong artificial light. This ocular condition continued till her death. The abdomen was painful and Swollen. Her mind remained clear, but apathetic, till the sixth day, When she fell into a stupor. On the same day all the extremities became paretic and partially anaesthetic. Up to this time the muscular power had been normal. The paresis and anaesthesia were most marked on the right side. The pulse was rapid, quick, and feeble. A day later the left foot and right hand were less paretic, and her mind was clear, but the senses blunted. She answered questions slowly and after an interval, and com- plained of pain in the head. On the eighth day she was restless and irrit- able, and had some right facial paralysis, while power in the left foot and right hand was still further improved. The ninth day she was delirious and unconscious. On the eleventh day she no longer moved or spoke, and paid no attention to an explorative incision. On the fifteenth day she died from asthenia. The temperature remained below 100° till the close of the fourth day, when it rose to 103°. After that it varied from 100° to 102°–H, usually was 101°-i-till the twelfth day, when it rose to 104°, and was from 108° to 104.5° till she died. 286 NEW YORK STATE MEDICAL ASSOCIATION. Necropsy.—Head large and unsymmetrical, and skull thick. No lesion of the scalp or of the bone before removing the calvarium. The occiput was disproportionately large, and the right occipital fossae were much larger than the left. The left, middle and anterior fossae were rather larger than the right. A fissure began at a point in the squamous portion of the left temporal bone, beneath the external wound, and, passing through the anterior surface of the petrous portion, terminated in the optic foramen. This fissure was not open, but the fragments were quite movable. There was no epidural haemorrhage, but pressure was made upon the facial nerve by interosseous haemorrhage as a result of the frac- ture. There was no meningitis, and scarcely the usual amount of Serum in the meshes of the pia. There were slight lacerations upon the under Sur- face of the right temporo-sphenoidal lobe, and one somewhat larger upon its external border, from which a moderate amount of blood had spread upward over the occipital lobe, barely reaching the parietal. Upon Sec- tion, the cerebral vessels were found to be distended with blood, which flowed from the puncta vasculosa. The veins could be seen in congeries and filled with coagula. The brain substance was softened and Oedematous, so that the serum followed the knife. The ventricles were distended with serum. Subsequent microscopic examination of the brain tissue in the recent state disclosed no inflammatory changes. There was a considerable extravasation of blood behind the peritonaeum on the right side, but no injury of the viscera. There were no serous effusions in the cavities of the body, and no chronic visceral lesions. CASE XXV. Male, thirty-seven years of age. Cause of injury un- known ; scalp wound in right posterior temporal region ; hemorrhage from right ear; mental condition stupid, but consciousness retained ; in continence of urine and faeces. The patient had been drinking to excess. On the next day he had active delirium, with tremulous muscles and delu- sions, and intervals of semi-unconsciousness. On the sixth day there was general muscular rigidity, stertor, and muttering delirium. The right pupil was slightly contracted, with slight serous discharge from right ear and slight right facial paralysis. Unconsciousness followed. On the eighth day there were two slight convulsions involuing both arms, the face, and eyes. The face was drawn to the right and the eyes turned upward. Paralysis of right arm and face succeeded, and a little later the surface temperature of the left side was found to be 102°, while that of the right side was normal. Rectal temperature, 105.6°, which soon de- clined to 104.8°. Death two hours later. Post-mortem temperature, 106°. The temperature varied from 100° to 102° till fourth day, then from 108° to 104° to last day, when it was as noted above. Necropsy.—Fissure across petrous portion of right temporal bone. Large subarachnoid serous effusion. Thin cortical layer of blood cover- ing whole of parietal and occipital lobes on both sides of the brain. Men- ingeal vessels congested. Brain structure everywhere oedematous. Mi- nute vessels filled with coagula. Fluid blood in anterior cornu of left lateral ventricle. Laceration of upper and outer surface of right frontal STUDY OF INJURIES OF THE HEAD. 287 lobe, and upon upper and outer surface and posterior border of left occipi- tal lobe. A third laceration existed at the base of the brain upon either side of the median fissure of the cerebellum. Neither of these lacerations was larger than a walnut, and neither involved a rupture of the meninges, though they all reached the surface of the brain. CASE XXVI. Male, twenty-three years of age; thrown from a wagon. The ambulance surgeon found him dizzy and feeling ill. He had no other symptoms except a scalp wound in right temporal region, After admission to hospital he was entirely conscious and dictated a letter. There was haemorrhage from right ear and nostril. Temperature, 100°. No other symptoms. Soon afterward he vomited blood copiously and became un- conscious with stertor, and died in four hours from time of admission. Necropsy.—Depressed fracture of right frotal bone an inch from median line and just anterior to coronal suture, triangular in form with apex extending to superciliary ridge. One fissure, originating in this depression, ran through right orbital plate, and greater and lesser wings of sphenoid, into middle fossa ; another one ran through Squamous into petrous portion of temporal bone, terminating upon its anterior surface. There was an epidural clot extending over lateral aspect of right frontal lobe into the middle fossa. This portion of the frontal lobe was much flattened and compressed. There was no subdural haemorrhage and no superficial lacer- ation of the brain. There was a small effusion of blood in the meshes of pia on either side of the medulla, behind the pons, parallel to the anterior columns. The whole brain was hyperaemic, with a multitude of punctate extravasations, and the minute vessels were filled with coagula. Upon Section, a number of extravasations were found in the substance of the pons, mainly in the transverse fibres, but some in the longitudinal fibres of the crura. The smaller ones were of the size of a robin-shot. The largest one was half an inch long by a quarter of an inch wide, and was just below the surface on the right external border of its inferior surface. CASE XXVII. Male, thirty years of age; cause of injury unknown ; unconscious ; coma continued till death ; haematoma of scalp at vertex; ecchymosis at base, right side; slight haemorrhage from right nostril; Stertor; pulse, 130, irregular and weak ; temperature, 94°; rose to 102° Some hours later; both eyes protruded and both pupils were dilated, left pupil most markedly so; some rigidity of right side; died same day, eight Or ten hours after admission to hospital. Necropsy.—Fracture through petrous portion of right temporal into the occipital bone and into middle fossa. No fracture of vertex. Epidural clot in right inferior occipital fossa. Thin subdural clot over both frontal lobes, especially over left, extending nearly to fissure of Rolando. Small *Ceration of left frontal lobe on its under surface near anterior border. CASE XXVIII. Female, forty-five years of age; fell ten feet upon her head; Scalp wound in right parietal region; temperature, 98.8°. Twenty *utes after admission left lower extremity became paretic, patellar re- flexes lost. Three days later temperature suddenly rose from 99%+ to 102°. 288 NEW YORK STATE MEDICAL ASSOCIATION. Next day patient became delirious. Evening temperature, 105.2°; fol. lowing morning, 106°. Death five days after reception of the injury. Necropsy.—Fracture beginning in squamous portion of right temporal bone, extended through both anterior fossae, involving greater wing of right sphenoid and both orbital plates. Subdural clot, the size of a pigeon’s egg, Occupied the left middle fossa. Laceration of inferior sur- face of left temporo-sphenoidal lobe. CASE XXIX. Female, sixty-six years of age ; found unconscious at foot of cellar stairs; supposed to have been thrown down. Scalp wound in left inferior temporal region ; left malar bone fractured and left side of face much contused ; coma, stertor, and frothing at the mouth ; moist bronchial rāles; right pupil dilated, left pupil invisible from ecchymosis; right upper extremity anaesthetic and soon became paralysed ; tempera- ture, 101-6°. Three hours later the patient was apparently moribund. On the following day she was conscious and rational, and the paralysis and anaesthesia had disappeared ; the pupils were normal; urine incontinent ; temperature, 99°--. For a week's time her condition remained practically unchanged, except that her temperature gradually rose to 108°, and in the last three days gradually fell to 100°, and that the subconjunctival haemorrhage increased. Her mental condition was apathetic, and she could be rarely induced to make a mono-syllabic answer to a question asked. On the eighth day she suddenly became unconscious. Her tem- perature rose to 104.8°, and within two hours fell to 102.8°. She became weaker and died during the ninth day, her temperature having again risen to 106°. Ten minutes post mortem it was 105.2°. Mecropsy.—An open fissure extended through both tables of the bone from a little above and to the left of the external occipital tubercle to the left foramen lacerum posterius. There was moderate subarachnoid serous effusion. There was an apparent laceration on the median aspect of the left frontal lobe, the real character of which only became obvious upon further examination. The interior of both frontal lobes was disorgan- ised and destroyed, having been broken down by subcortical laceration. On the left side the clot was very solid, and the external layers of fibrin on its inferior aspect were partially decolorised. It had broken through into the anterior part of the lateral ventricle and also through the cortex on the median surface, involving for a space of half an inch the motor arm area, and the sensorial centre below it in the gyrus fornicatus. It was this which at first sight seemed to be an independent lesion. The clot in the right frontal lobe, which was of equal size, had nowhere broken through the cortex or into the lateral ventricle. There was no cortical haemorrhage, although there was a deep laceration on the posterior border of the left cerebellum. The interior of the brain generally was softened and reddened in patches. CASE XXX. Female, fifty years of years of age; no history; admitted as case of apoplexy. Small lacerated scalp wound in left posterior parietal region ; slight haemorrhage from both nostrils; patient unconscious ; STUDY OF INJURIES OF THE HEA. D. 289 movements sluggish; left pupil dilated, right contracted; incontinence of urine and faeces; face flushed ; visible pulsations of carotids; fine linear fracture running toward the base discovered by incision ; temperature, 101°; at night, 101-8°; next day, 101-2° to 101°; then rose steadily to 106.8° on the next day, when death ensued, three days and a half after ad- mission, without consciousness having at any time been regained. Post- mortem temperature, 109°. On the last day of life, sensitiveness of the corneae was markedly diminished and sensation was evidently blunted all over the body. Necropsy.—A fissure extended from left of occipital protuberance through posterior fossa and petrous bone to foramen ovale. There was a large, firm subdural clot, three fluid ounces by measurement, in the anterior fossae, and a slight subdural haemorrhage into right posterior fossa around the foramen magnum. A deep laceration extending below the cortex, on the under surface of the left cerebellum, made an excavation three-quarters of an inch broad from the posterior nearly to the anterior border. Another extensive laceration deeply excavated the inferior portion of the right frontal and extended into the external border of the right temporo- sphenoidal lobe. Haemorrhage from the latter laceration reached the ver- tex anteriorly and filled the fissure of Sylvius. Another laceration existed in the middle portion of the gyrus fornicatus, filled with brain detritus and coagulum, and extended through the cortex. This was oval in form and half an inch in diameter. There was some general contusion of both hemispheres, most marked in posterior portions. CASE XXXI. Male, forty-five years of age ; thrown from a horse and Struck upon his head. He was temporarily unconscious, but on the arrival of the ambulance was able to stand, and said he felt very well. He again became unconscious on his way to the hospital. His pupils were Contracted and his pulse barely perceptible. He suddenly became cyanotic and died twenty-five minutes later. Necropsy.—Haematoma of scalp in left occipital region; blood fluid ; stel- late fracture of calvarium with centre in left upper occipital region, and With fissures extending downward into foramen magnum, forward into middle fossa, and upward and laterally ; epidural clot in occipital region; Subdural haemorrhage in inferior occipital fossa compressing the medulla; extensive subarachnoid haemorrhage over temporo-sphenoidal and frontal lobes on both sides, with laceration of inferior surface of right frontal and temporo-Sphenoidal lobes, and in slighter degree of same region on the left side. CASE XXXII. Male, thirty-four years of age; struck by a brick falling from the fourth story. Compound, comminuted, depressed fracture of the right parietal bone extending into the base; haemorrhage from right ear; patient conscious and without general symptoms; temperature, 100.4°, and became normal; depressed bone elevated; no injury of dura. After twenty-three days subcortical abscess of brain developed, with left hemiplegia and anaesthesia. Dura incised and abscess evacuated. Died sixteen hours later. Temperature, 108°. 19 290 NEW YORK STATE MEDICAL ASSOCIATION. Necropsy.—Fissure through whole length of anterior surface of right petrous portion of temporal bone; no superficial cerebral laceration ; sub- Cortial abscess cavity of small size, which had been evacuated ante-mortem through the angular gyrus. This case is fully reported in the New York Medical Journal, March 29, 1890. CASE XXXIII. Male, thirty-three years of age ; cause of injury un- known. Consciousness lost and never regained ; scalp wound in left posterior parietal region; haemorrhage from left ear; both pupils dilated, but the right contracted later; pulse, 60 ; muscles relaxed and later became rigid. Death in twelve hours. Temperature on admission, 99-6°; later, 98-6° to 100°4°; one hour post-mortem, 101-2°. Wecropsy.-Semicircular fracture of squamous portion of left temporal bone, with fissure extending into anterior surface of petrous portion ; deep, well-defined laceration, laterally and posteriorly, of left temporo-sphenoidal lobe, from which a thick clot extended over the occipital region; brain in all its parts excessively hyperaemic ; on section, the surface was repeatedly bathed in blood as it was each time wiped away; no punctate extravasation Or coagula in minute vessels. CASE XXXIV. Male, forty years of age ; said to have fallen down one flight of stairs. Scalp wound in right occipito-parietal region ; haemor- rhage from the nose and later occurrence of haematemesis; unconscious- ness; stertor; pulse, 96 and full; respiration, 18; temperature, 100°; pupils normal till just before death, when they dilated; restlessness; incontinence of urine ; temperature rose gradually to 102°6° one hour ante-mortem. Died in fourteen hours. Necropsy—Linear fracture in right parietal bone and extending through middle fossa and greater wing of sphenoid ; small epidural clot and larger subdural clot beneath the site of fracture ; dura ruptured ; cortical lacera- tion an inch and a quarter by three-quarters of an inch in anterior and in- ferior part of right parietal lobe; another laceration involved anterior half of middle temporal convolution on the same side. The whole brain Very hyperaemic, most markedly so on left side posteriorly. In almost the exact centre of the left cerebellum there was a laceration about the size of a pea filled with fluid blood. CASE XXXV. Male, forty years of age; fell six stories. Abrasion about left eye; unconscious; pulse and respiration too rapid to be counted ; temperature, 101°; both pupils strongly contracted ; rigidity of both lower and the right upper extremities; temperature in articulo mort?8, 100'4”--; two hours post mortem, 99°-H and pupils dilated. Necropsy.—No superficial injury upon any part of the body except the :abrasion noted. An extravasation of blood existed below the scalp, COVer- ing the whole left parietal region. Separation of coronal suture, left side, from about its middle point, extending outward and terminating in a fissure which, in the middle fossa, divided into two lines, one lost in the greater wing of the sphenoid, the other at the petro-mastoid junction. No epidural or subdural haemorrhages. Cortical haemorrhages from menin- STUDY OF INJURIES OF THE HEAD. 291 geal contusion—one covering left frontal and parietal lobes superiorly and laterally, another covering right parietal and occipital lobes on either side of their junction. No laceration on the surface of the brain, or in any part, except one three-eighths by one-fourth of an inch in the left corpus striatum, subcortical, and at junction of middle and posterior thirds. Excessive general hyperaemia. - CASE XXXVI. Male, sixty-five years of age ; fell into the hold of a vessel; haemorrhage from the ears and into subconjunctival tissue; con- scious for twenty-four hours; both pupils dilated ; temperature high ; died in twenty-four hours. CASE XXXVII, Male, sixty years of age ; knocked down by a truck; scalp wound in right posterior occipital region. A linear fracture run- ning backward and downward was discovered by incision. Patient un- conscious and restless. Pupils contracted ; pulse, 66; very slight move- ments of right side of body; no facial paralysis; spoke only in monosylla- bles. In a short time right hemiplegia became complete, pulse Weaker, temperature lower, and there was a slight general convulsion lasting about ten seconds. Four hours later coma was profound, pupils Small and irresponsive, pulse and respiration very irregular, and restlessness ceased. The patient was trephined over left motor area. The fissure was found to extend downward behind the mastoid. Epidural haemorrhage disclosed, and, after incision of dura, subdural haemorrhage. He died three hours later, and eleven hours after reception of injury. CASE XXXVIII. Male, forty years of age; cause of injury unknown; contusions behind both ears; free haemorrhage from right ear, and during the night from both ears and mouth ; pupils contracted ; pulse full and Slow ; breathing labored ; temperature, 99.2°; became 105°. He did not regain consciousness, and died six hours after admission. CASE XXXIX. Male, twenty years of age; fell thirteen feet; large haematoma in left posterior parietal region ; unconscious; oozing from left ear and nose; pupils contracted, and eyes turned persistently to the right; mouth drawn slightly to the right; breathing irregular; vomiting free; extremities cold and muscles relaxed ; urine incontinent; tempera- ture, 99.5°. Soon after admission haemorrhage from nose ceased, but con- tinued from the ear. Patient could be roused partially but with difficulty, became restless, and moved his right side rather less freely than the left. Temperature, 101°. Two hours after admission breathing became stertorous, and tonic spasms, beginning in the right arm, became general. Two at- tacks of opisthotonos followed, and ceased after thirty minutes. Left Pupil became the larger, while the right eye still turned to the right on *posure. Temperature, 105°; pulse, 96; respiration, 32, and of the Cheyne-Stokes Variety. An hour later coma was profound, with slow and Stertorous respiration. Temperature, 106.6°. Respiration became *Sufficient, four to the minute, and face cyanotic. Death occurred in four hours. Pupils post-mortem were widely dilated. 292 NEW YORK STATE MEDIOAL ASSOCIATION. CASE XL. Male, thirty years of age ; fell three stories to the pave- ment; four ribs fractured on the right side; contusion over right eye, and slight right subconjunctival haemorrhage; unconscious; skin cold and moist ; pulse, 120; temperature, 100°. Pulse became weaker and respiration more labored, and death ensued in five hours and a half after reception of injury. No pulmonary symptoms. - CASE XLI. Male, forty years of age ; cause of injury unknown ; ex- tensive contusion over right parietal region; haemorrhage from right ear and nose; unconscious ; stertor ; died in four hours and a half. CASE XLII. Female, forty-seven years of age ; fell on the street in a convulsion during a debauch ; had other convulsions before admission; left side of head and eyelid much contused ; mental condition stupid ; pupils normal ; breathing stertorous ; pulse, 108; convulsions continued during the day and night ; no interval of consciousness. During the morning a severe haemorrhage occurred from the mouth without previous Warning. In the afternoon pulse and respiration became frequent. The blood which came from the mouth was bright in color, non-aerated, and Said to be more than eight ounces in amount. The next day the convul- sions were diminished in frequency and were general, but more severe in the right arm. No initial symptom noted. Both arms were rigid and head constantly turned to the right. There were in all twenty-three con- vulsions. Death occurred in thirty-eight hours. Temperature, one hour after admission, 102-4°; morning of next day, 105.6°; later, 107.4°, 106.2°, 107.8°–the last, one hour before death. CASE XLIII. Male, seventeen years of age ; fell one story ; large haematoma on left frontal region ; unconscious till death ; haemorrhage from nose, mouth, and left ear, and under conjunctiva of both eyes; pupils equally dilated ; slight convulsive movements of right side SOOn terminating in right hemiplegia, with rigidity of left side; death from pulmonary oedema occurred in five hours; temperature one hour before death, was 105'4°. CASE XLIV. Male, thirty-seven years of age ; jumped from a fourth- story window to the street while drunk; lacerated scalp wound in left posterior parietal region, and fissure running from it into posterior fossa ; both pupils widely dilated ; patient loud and abusive in language ; slight left facial paralysis; incontinence of urine; pulse, 118, soon becoming irregular and almost imperceptible. The patient became quiet, and a little later comatose. Temperature, 97.6° by rectum. Three hours after admission he had three clonic spasms of right arm at varying points. Died in six hours after admission while under ether, given for reduction of a dislocated hip. CASE XLV. Male, thirty years of age ; struck by a falling ladder ; haemorrhage from mouth and nose, and blood and brain matter exuded from the right ear; both eyes protruded, the right eye the more so; both pupils contracted and irresponsive to light; right facial paralysis; respira- STUDY OF INJURIES OF THE HEAD. 293 tion stridulous. Right pupil soon began to dilate slowly. Temperature, 100°; pulse, 93. Patient remained unconscious till death, two hours after injury. CASE XLVI. Female, thirty-five years of age ; fell down stairs; admitted next day, still unconscious ; ecchymosis in left posterior parietal region; haemorrhage from left ear; left eye protruded; left pupil dilated. Temperature, 101° ; pulse, slow. Vomiting profuse. Next day paresis of whole right side; urine incontinent ; Some pulmonary oedema. On the third day rigidity of the muscles of the back of the neck. Haemorrhage from the ear continued a week, lessening in amount and becoming Serous in character. Patient continued unconscious till death, at the end of ten days, from asthenia. Temperature ranged from 100° to 102° till the morn- ing of the eighth day, when it suddenly rose from 101° to 103°. From this time it rose, with morning depressions, steadily to 107.4° on the day of her death. CASE XLVII. Male, thirty-five years of age; cause of injury unknown ; found unconscious ; Small haematoma on left temple ; haemorrhage profuse from both ears; evidence of previous haemorrhage from both nostrils; pulse scarcely perceptible; stertor; pupils both equally dilated; complete relaxation of limbs, and no response to peripheral irritation. Left facial paralysis was developed two hours before death, which occurred in six hours without restoration of consciousness. Temperature on admission was 98.6°, rose to 99°-H; pulse, 64 to 128; respiration, 24. CASE XLVIII. Male, twenty-four years of age ; fell down stairs; wound over right eye ; haemorrhage from right nostril; coma ; stertor; pupils contracted ; temperature, 98°5°; pulse, 120; no paralysis or muscular rigidity ; reflexes normal; fracture of left thigh. Clonic spasm of left side five hours after admission. Death in ten hours after reception of injury. Hourly temperature, 100°, 101°, 102-4°, 102-4°, 103°, 104.4°, 105°, 106’4”. Thirty minutes post-mortem, 108-8°. CASE XLIX. Male, four years of age ; fell two stories, striking the back of the head; small scalp wound just above external occipital protu- berance; large haematoma above each ear; profuse haemorrhage from both ears and mouth, and haematemesis; depressed fracture could be felt beneath the wound ; unconscious; right pupil dilated ; neither pupil responsive ; slight rigidity of muscles of right side. Temperature, 100.8° ; pulse and º very rapid ; respiration became Cheyne-Stokes. Died in four OUITS. CASE L. Male, fifty-nine years of age ; fell two stories through an elevator and struck his head; contusion about right ear and nose ; uncon- scious for ten days; haemorrhage from right ear and nose and under right Conjunctiva ; stertor; pupils irregular. At the end of a week restless, and required to be kept in bed by an attendant. Discharge from ear Straw-colored. At the end of two weeks patient entirely conscious. Ten days later he walked a little and began to recognise people, and after another ten days he was mentally recovered. 294 NEW YORK STATE MEDICAL ASSOCIATION. CASE LI. Male, thirty-three years of age ; thrown from a truck and received a blow upon the head ; scalp wound in left temporal region; pro- fuse haemorrhage from left ear; pupils regular. He was semi-comatose, but conscious and rational next day, and two days later became delirious. Haemorrhage from the ear ceased on the sixth day, delirium continued a week, and vertigo for upward of three weeks. No further symptoms were developed. CASE LII. Male, thirty-five years of age ; struck on the head by a brick falling eight stories; not made unconscious; compound, comminuted, depressed fracture at right temporo-parietal junction; squamous portion of temporal much comminuted, and one large fragment driven into the brain ; haemorrhage from right ear and nostril; right pupil contracted ; little or no shock. He recovered with some deafness remaining in right ear. CASE LIII. Male, thirty-five years of age; fell down stairs while drunk; coma; stertor; haemorrhage from left ear, which continued twenty-four hours; pupils contracted. Regained consciousness in twelve hours. Five days later, left facial paralysis, both upper and lower face involved, and food accumulated between cheek and jaw; ptosis, etc. No loss of sense of taste. He entirely recovered from paralysis, and suffered only from occasional vertigo. CASE LIV. Male, nineteen years of age ; thrown from his horse while riding, and struck on the back of his head; contused wound in right occipital region ; profuse haemorrhage from right ear; pupils contracted; unconscious till after his removal to his house, a distance of two miles. He then had severe nausea and vomiting, and was somnolent for several hours. The next morning his pulse and temperature were normal, and he suffered from severe pain in the head, which continued for three days. Haemor- rhage from the ear ceased at the same time. There was no rise at any time in pulse or temperature. At the end of ten days there was still some pain and tenderness on deep pressure just above and behind the ear. His recovery was complete. CASE LW. Male, forty-four years of age ; said to have fallen and been struck by a plank ; admitted to alcoholic ward, and next day trans- ferred to surgical service when he had partially recovered consciousness. The left upper and lower extremities which had been rigid, had become hemi- plegic and anaesthetic. There was an abrasion of the nose, a contusion of the left eye, and a haematoma of the right posterior parietal region. Three days later the left hemiplegia had become complete; movements from the bowels were conscious but involuntary; bladder controlled ; temperature. 99°. His mental condition had been unchanged since he recovered con- Sciousness. He answered questions rationally, and never varied in his ex- planation of the manner in which his injury had been received. He talked constantly and rambled in his speech. Upon incision, an open fissure Was disclosed, which ran obliquely across the right parietal bone, from the an- terior Superior angle, and into the occipital as far as it could be Conven- ently traced. There was no depression. A large opening was made STUDY OF INJURIES OF THE HEAI). 295 through the bone by trephining and use of the rongeur. An epidural clot was found to extend from the coronal suture in front to the superior occipital fossa behind, and from the median line to the middle fossa, and was an inch and a half in thickness in its central portions. This clot, when removed, measured four ounces and a half by volume, and left a large cavity, the result of cerebral compression. The dura was apparently uninjured. As haemorrhage was free from some inaccessible point beneath the bone, the cavity was temporarily packed with gauze. Two hours after the opera- tion he could move the left leg. Twelve hours later there was sensation in the left arm. The next day sensation was perfect, movements of the left arm still restricted, and movements of the bowels occurred which were con- trolled. Temperature, 98°5°. The second day the brain had regained the volume it had lost by compression, and his mental condition was apparently normal. In four days he was in all respects entirely well, except for his external wound. CASE LVI. Male, twenty-three years of age ; thrown from his horse and sustained a depressed fracture of the left frontal bone two inches above the orbit. Partial loss of consciousness; haemorrhage from nose and mouth ; pupils normal; skin pale and moist, and extremities cold; two or three hours later projectile vomiting and haematemesis. There was slight ecchymosis of the left upper eyelid before the vomiting ; after it both eye- lids became excessively ecchymotic, and at the same time the outer half of the left conjunctiva became filled with blood. The temperature was usually about 99°, never above 100.5°. He had temporary amblyopia, and no other results followed. CASE LVII. Male, forty-five years of age; knocked down and beaten about the head; lacerated scalp wounds in left fronto-parietal region; Coma; haemorrhage from both nostrils; pupils normal; pulse, 100. He recovered partial consciousness in one hour, and became excessively irri- table; full consciousness returned next day, and he was removed from the hospital. CASE LVIII. Male, twenty-six months of age ; fell four stories; ex- tensive Scalp wound in right occipital region ; repeated vomiting; haemor- rhage from right ear. Three hours later he became restless, had clonic Spasms upon the right side, and gradually lost consciousness. There was apparent complete right hemiplegia; movements of the left side were easily induced ; pulse, 130 and weak; breathing stertorous. Conscious- ness gradually returned within twelve hours, and no paralysis remained. There were no further symptoms. tº CASE LIX. Male, thirty years of age; fell from elevated railroad to sidewalk, striking upon left side of head and face; contusion over left eye; semi-conscious; haemorrhage from right ear; pulse and respiration slow. The next day patient recovered consciousness enough to discover that he had become blind in the left eye. He responded slowly to questions and slept most of the time. Ophthalmoscopic examination of the left retina Was negative. The left pupil would not respond to direct exposure to 296 NEW YORK STATE MEDICAL ASSOCIATION. light, but would contract with the other pupil on simultaneous exposure. In the opinion of Dr. P. A. Callan, the blindness was due to pinching of the optic nerve by a fracture involving the optic foramen. Fifteen days later Dr. Callan found commencing atrophy of the optic nerve. Eight days after the injury there was partial left facial paralysis, and the tongue deviated to the right. He complained of pain over the left eye and be- hind the right ear. A slight sero-sanguinolent discharge began to flow from both ears, continued for some days, ceased, and reappeared from the right ear. Temperature on admission was 99°, rose to 100°, and afterward varied, usually from 99° to normal. The patient, a man of unusual intelligence, stated, after his recovery, that for five weeks after his accident he was unable to recollect the attend- ant circumstances or anything that happened about that time or afterward; that his mental condition was one of great confusion. After that period his memory was restored and his mental confusion disappeared. His re- covery was ultimately complete, with the exception of loss of sight of the left eye. The diagnosis made was ; Fracture of the frontal bone, commencing on the left side, extending through the anterior fossae and through the right middle fossa and petrous portion, involving the left optic foramen and lacerating the pre-frontal lobe. CASE LX. Male, forty-seven years of age ; knocked down by a blow, and his head struck heavily upon the pavement ; slight contusion upon lip and over right eye; pulse, 72; temperature, 100:2°; unconscious; stertor; pupils normal ; soon became delirious and was unable to articulate. He remained in a condition of stupor and delirium for ten days; required me- chanical restraint. He was unable to articulate, and was dysphagic; at- tempted to drink his urine. His mental condition and power of articula- tion then improved for two weeks, though he developed left facial paralysis, involving lower face; dysphagia disappeared. There was then an interval of a few days, when he was irritable, restless, and disposed to wander about the ward at night. His temperature varied from 100° to normal, and was usually at the higher point. From this time he became Quiet and conversed intelligently, though his mind wandered. He had no recollection of his injury, of what preceded it, or of anything that occurred afterward. He failed to recognise his location or to appreciate his sur- roundings. His memory of more distant events was better, but still defective. His laugh was vacant, and there was some perceptible loss of power on the left side. He continued in a demented condition and inci- dentally a dipsomaniac till his removal to an insane asylum within the last month, two years after the injury. CASE LXI. Male, twenty-two years of age; fell two stories and struck right side of the head and face and right shoulder; contusions of those regions and fracture of acromion; unconscious; haemorrhage from right ear, and four hours later from the nose; regained consciousness in five hours; haemorrhage from ear ceased in three days; temperature, 101° to 100”; normal after four days. STUDY OF TWJURIES OF THE HEAD. 297 CASE LXII. Male, twenty-two years of age ; fell three stories; contu- sions of right side of head, face, and eye; haemorrhage from right ear and mouth; unconscious; pulse slow and full (60); breathing labored; tempera- ture, 101°; pupils normal. Respiration soon became easier, but the patient was irritable and restless. He did not regain consciousness for five days, during which time he continued to be irritable when disturbed, and was not wholly rational for five days longer. Toward the end of the second week his articulation became thick, and right lower facial paralysis became evident. At the same time a swelling without discoloration of the left side of the face, which had been present since admission, perceptibly increased, but soon afterward disappeared. The facial paralysis persisted, and the difficulty of articulation increased. His mental condition varied, but pro- gressively deteriorated. There was slowness of perception and hesitation in expression. His laugh was silly and his manner vacant. There also seemed to be a sensory aphasia at a late period. In reply to questioning about the manner of his accident, he would talk about taking a basket of clams from Koster & Bial's. He might say “Koster & Bial's,” but was quite likely to say “Koster and clams.” At the beginning of the second month there was a sudden change. His mind in a day became clear ; he knew where he lived and that he was in a hospital. He conversed ration- ally about his accident and how it occurred. He lost his delusions and rested quietly at night, though his speech was still a little indistinct and his facial paralysis had not entirely disappeared. Temperature after the third day was rarely above 99° and oftener below it. His recovery was ultimately complete. . CASE LXIII. Male, forty years of age; fell down five steps of a stair- Way ; walked home ; haemorrhage from right ear; had two convulsions next day and was then taken to the hospital; haemorrhage from the ear still continued; stupid ; muttering; two other convulsions, most marked On the right side, followed by mild delirium throught the night. No pre- vious history of epilepsy or excesses in drink. Temperature, 101:2°. Three days later patient was still stupid, said little and that incoherently, and was delirious. Temperature had ranged from 101-2° to 100.6°. He Was transferred to Bellevue, and there became wildly delirious for three days, and then quiet and rational. Temperature, 98.8°. No further his- tory noted ; no other Symptoms. - CASE LXIV. Male, forty-two years of age ; cause of injury unknown. Semi-conscious and drunk; haemorrhage from right ear which continued eight days; membrana tympani ruptured ; violent mania for two days and mild delirium two days longer; temperature, 100°. Four days after- Ward he suffered pain in the head; had occasional delusions; his mental Processes were slow, and his tongue deviated to the right; urine and *ces incontinent. In the second week he became rational and only Occasionally soiled the bed. His tongue still deviated. At the end of a *9th he no longer had symptoms; even the deafness had improved. Temperature second day, 103°; gradual decline to 99° in four days. After Seventh day habitually normal to 99°. 298 NEW YORK STATE MEDICAL ASSOCIATION. CASE LXV. Male, forty years of age; fell down a gang-plank. Un- conscious ; haemorrhage from both ears, more from the right ; pulse, 100; temperature, 100°. After some hours consciousness returned and he was able to speak. Delirious through the night. On the next day his tongue deviated to the right ; pupils dilated, left more so than the right; mind still clouded ; temperature, 99.6°. Four days later he was rational. No further symptoms. CASE LXVI. Male, twenty-three years of age; walked out of a window while sleeping, and fell three stories to a stone pavement below, striking an iron fence on the way down. He remained unconscious for fifteen or twenty minutes. On admission, there was a wound of the external right ear. While this wound was being dressed a very profuse serous discharge began from this ear and continued for several days. Pupils and respira- tion normal; severe vertigo, aggravated on attempting to rise or on open- ing his eyes; he vomited several times; pulse, 90 ; temperature, 99°. On the fourth day he had upper and lower incomplete facial paralysis which continued for a week's time. On the eighth day he had three epileptiform convulsions, and one on the next day. The head and eyes were first turned to the right, then the arms, and finally the legs were involved. On the twentieth day he began to have severe pain in the right ear, and as the mastoid region later became swollen and inflamed, it was trephined for exploration, with negative result. The temperature but once exceeded 99°. The mastoid inflammation disappeared at once after trephining. Recovery was complete. CASE LXVII. Male, fifteen years of age ; kicked in the back of the head by a horse. No apparent external injury ; profuse haemorrhage from right ear; was moaning and restless; became delirious after a few hours; afterward irrational and incoherent ; irritable ; temperature, 100°; delirious or irrational for five days; temperature, 100° to 102° ; removed from hospital in two weeks; temperature, 99°; still had delusions. CASE LXVIII. Female, six years of age; fell two stories to pavement; unconscious ; lacerated wound over right eye and haematoma ; contusion of face ; severe haemorrhage from mouth and nose, and haematermesis ; subconjunctival haemorrhage in both eyes; pupils dilated ; stertor; respiration frequent ; temperature 99°; reflexes lost; incontinence of urine and faeces; surface irritation caused violent convulsions; initial Symptom in the eyes, continued twenty-four hours; also haemorrhage from nose and mouth. After that time all the symptoms disappeared, and patient was out of bed on the tenth day; temperature rose in three hours from admission to 103.2°; fell to 98.6° on the second day. CASE LXIX. Male, four years of age; struck by some falling object : contusions over left frontal and right parietal eminences; haemorrhage from mouth, nose, and both ears, and continued from left ear for five days; unconscious; left pupil dilated; left facial paresis; temperature, 99"; somnolent forty-eight hours, but rational when roused ; incontinence of urine and faeces; temperature, 100° on second day and 100:4° on third STUDY OF INJURIES OF THE HEAD. 299 day; did not get below 100° till tenth day; pulse usually 120; symptoms gradually disappeared. CASE LXX. Male, forty years of age ; fell one story to pavement, striking back of his head ; scalp wound in right occipital region; haemor- rhage from left ear; left pupil dilated; soon became normal; unconscious; partially restored in ambulance; on admission, restless and delirious; temperature, 99.4°; pulse, 60; respiration rapid ; moved right side only ; incontinence of urine and faeces. Temperature ranged during the first week' from 100°–H to 101°; then became 99°–H in the morning, and at end of second week became normal ; pulse varied from 62 to 54; required con- tinuous mechanical restraint for four days, and at night for one month. His mind underwent the typical changes (see remarks on diagnosis), and became ultimately completely restored. - FRACTURES OF THE VERTEX. CASE LXXI. Male, fifty-two years of age ; fell backward and struck back of his head, at the same time fracturing his left patella. At the hos- pital to which he was taken, his head injury did not attract attention. He was delirious on the second day and had a convulsion on the fifteenth, and his condition was attributed to the alcoholic habit. Six months later the patella was wired for non-union. His muscular rigidity under the anaes- thetic was notable. His temperature the day following the operation was 99° until one o'clock P. M. Half an hour later, and without premonition, he had an epileptiform convulsion which began in the face and became general, and was followed by wild delirium. He had two other similar Convulsions, also followed by wild delirium, and the last by a temperature of 103°. The kidneys acted freely and the urine was normal. The wound of operation was the seat of primary union. The temperature was normal On the next day and so remained for fifteen days. At that time an attempt Was made to coapt the fragments of the patella, which he had torn asunder in his convulsions and delirium. This failed, and there was some subse- Quent Suppuration which elevated the temperature for the next ten or tWelve days to 99°-- and to 102°. The wound was then healed and the temperature again became normal. At each dressing great muscular rigidity and tonic spasm had been noted in the affected limb (left). Just One month from the previous attack convulsions recurred, and were fre- Quently repeated for thirty-six hours. They were all marked by the same characteristics. Each one was preceded by great restlessness. In about fifteen seconds this was followed by wide dilatation of both pupils. The *uscles of the left side of the face began to twitch and the eyes deviated to the left. The muscular spasm extended to the other side of the face, then to the left arm and leg, and finally became general. The whole con- Vulsion lasted about thirty seconds. During the day the deviation of the *ft eye became permanent. The tendon reflexes were markedly increased. After the convulsions ceased he became delirious, and died nine hours later. 300 WEW YORK STATE MEDICAL ASSOCIATION. At the time of the seizure his temperature was 101'1", in twelve hours it became 102°, in twenty hours 104°, in twenty-four hours 104.8°, and after- Ward fell to 104°. AWecropsy.—The knee-joint of operation was found to be free from in- flammatory complication, and the wound practically healed. A depression was discovered in the skull just above the external occipital protuberance in the median line. This was confined to the external table and no lesion of the brain existed beneath it. At the opposite extremity, however, of the antero-posterior diameter, there was a circular laceration upon the an- terior border of the right frontal lobe, and another laceration existed upon the under surface of the left frontal lobe, upon the middle of the second and third orbital convolutions, an inch and a half by an inch in diameter. A still larger laceration of the base, at least three inches and a half by an inch and a half in diameter, existed upon the right temporo-sphenoidal lobe, involving a little of the first, and almost the whole of the second and third convolutions. All these lacerations were distinctly limited, softened, and of a brownish color, showing the considerable time which had elapsed since they were inflicted. The whole right temporo-sphenoidal lobe was greatly atrophied, indurated and pigmented. The pia, was thickened over each laceration. CASE LXXII. Male, forty years of age; cause of injury unknown; found unconscious in bed; contusions of forehead and left upper eyelid ; pupils regular and fixed ; right facial paralysis; both arms and right leg rigid ; pulse, 96; respiration, 36. Twenty-four hours later, right arm paralysed, but still rigid ; could not determine whether right leg was para- lysed ; pulseless; died in thirty hours; temperature at admission, 102’6”; twenty-four hours later, 105°. Mecropsy.—Haematoma over whole left parietal region. Linear fracture across whole length of parietal bone just above temporal ridge, recurving upon itself posteriorly for a little distance. Large epidural clot beneath the fracture, compressing and flattening the whole left hemisphere, and forming an oblique plane. General contusion of the whole brain, which was hyperaemic and studded with minute extravasations. CASE LXXIII. Male, twenty-eight years of age; received a blow upon the head from a falling elevator (lift); compound comminuted fracture of right frontal bone; wound filled with clot and brain tissue ; opening in the skull an inch and a half by half an inch in diameter. After cleansing the wound a cavity was left in the frontal lobe as large as a Mandarin Orange. The patient was semi-conscious, but mental condition soon be- came normal. Pulse, 68; temperature, 100:2°. Womited frequently. At the end of twenty-four hours he was rather heavy and somnolent, but could be easily roused, and was rational. Two hours later he was found in a comatose condition, with a temperature of 105.4°, and died soon after- ward, twenty-seven hours from the time he received the injury. Necropsy.—Two large fissures ran backward on either side of the skull, one terminating in the parietal and the other in the occipital bone. There STUDY OF INJURIES OF THE HEAD. 301 was no epidural haemorrhage. An irregularly shaped piece of the internal table was detached and rested upon the brain just above the cavity noted, but nearer the median line, and a subdural clot three inches in diameter and half an inch thick was situated just posterior to it upon the right frontal lobe. There was slight cortical haemorrhage in the left occipital region. There was no lesion at the base. The cavity made by laceration of the frontal lobe extended nearly to the lateral ventricle. The whole brain, in- cluding the pons, optic thalami, and corpora striatà upon both sides, and the cerebellum, was streaked with minute coagula, Some of which, an inch in length, could be teased from the vessels. CASE LXXIV. Male, thirty-two years of age ; fell thirty feet into the hold of a vessel, striking upon his back. Unconscious ; pulse and respi- ration slow ; stertor ; no other symptoms. Condition resembled that of alcoholic coma. Next morning the temperature was 101-6°; evening, 101°8. On the second day, A. M., 103-8°; M., 104.2°; P. M., 105.4°. Right hemi- plegia and both eyes turned to the left. Pupils normal. Pulse feeble and rapid. Respiration inadequate from pulmonary oedema. Still unconscious. On the third day temperature, A. M., 106’4”. Death in sixty hours. Mecropsy.—Separation of coronary suture from right frontal eminence to its left external extremity. Not much epidural haemorrhage. Lacera- tion of posterior extremity of left temporo-sphenoidal extending into occip- ital lobe. Consequent subdural haemorrhage of moderate amount, involv- ing left motor area and occipital lobe to the base. Another laceration existed on the posterior border of the left cerebellum. General contusion. CASE LXXV. Male, thirty-two years of age; fell from his truck. Con- tusion of left parietal region ; unconscious ; irritable when disturbed ; temperature 99°; pulse 60 and full ; coma continued for about a week With temperature from 99% to 100°, then a period of irritability and mild delirium which lasted two weeks longer. Mental condition after the first tWO Weeks apathetic and weak. He answered questions rationally when Spoken to, but rambled in his speeeh. He recognised his friends, but Spoke only when spoken to and had some delusions. At the end of a month he was transferred to Mount Sinai Hospital, and died there. Necropsy.—Fracture found in left occipito-parietal region. Laceration. CASE LXXVI. Female, twenty-three years of age ; suicidal gunshot Wound through right temporal fossa; median line of vertex presented a °onical elevation; haemorrhage considerable; patient unconscious with Stertor; coma became more profound; temperature fell to 95°; pulse rapid ; death in four hours. Accropsy.-Scalp infiltrated with blood. Bullet entered frontal bone a little above and external to right eye, penetrated the brain, passed inward, *PWard, and backward, and impinged upon the inner surface of the skull, *little to the left of the median line in the middle parietal region. It ele- wated two little triangular pieces of bone which remained attached to the P*ranium. The bullet then fell back into the brain. It had entered at the anterior extremity of the fissure of Sylvius, traversed the right frontal 302 NEW YORK STATE MEDICAL ASSOCIATION. lobe, just below the cortex and parallel to its curve, and then passed a little backward and across the longitudinal fissure below the longitudinal sinus, into the left parietal lobe ; after fracturing the left parietal bone and falling back into its cerebral track as noted, it rested about half an inch below the surface. The skull was very thick, and fissured from the point where the bullet entered. There was little intracranial haemorrhage. CASE LXXVII. Male, twenty-six years of age ; homicidal gunshot wound in right temporal fossa; patient unconscious; pupils normal; general muscular twitching ; coma became profound, and death followed in twelve hours. Necropsy.—Bullet entered just behind external angular process of right frontal bone, traversed the right hemisphere nearly in its antero-posterior diameter, just above corpus callosum, impinged upon inner surface of the occipital bone, and, rebounding through the opening in the dura, fell into the inferior occipital fossa. Considerable subdural haemorrhage. CASE LXXVIII. Male, forty-two years of age ; suicidal gunshot wound in right temporal fossa; patient unconscious; pulse, 70; no other symptoms. He soon regained consciousness, and was rational, but his mental processes were sluggish. He had syphilitic laryngitis and aphonia. Temperature, 99°. An attempt was made to remove the ball next day, the opening in the bone at about the right temporo-frontal junction having been enlarged by the trephine. The track of the ball could be traced about two inches and a half forward, downward, and inward, at which distance a piece of bone, carried inward by the ball, circular and comprising both tables, was discovered and removed. Considerable brain matter oozed out during this exploration. The ball was not found. No reaction followed the operation. The patient lived thirty days. His urine and faeces were voided freely, but without attracting his attention. The discharge of brain matter from the wound gradually diminished. At the time of his death the external wound had almost entirely healed. The most notable symp- tom in his condition was hebetude. He remained rational but quiet, list- less, and taking no notice of people or things, and without interest in what went on about him, with occasional intervals in which his mind seemed brighter. The temperature ranged from 100°–H to 103.6°, and was usually above 101°. * Mecropsy.--The ball entered the brain about the middle of the third right frontal convolution, and passed nearly transversely through the centre of both frontal lobes, and lodged just behind the ascending arm of the fissure of Sylvius on the left side, in the upper portion of the island of Reil. Its track passed just above the anterior horn of both lateral Ven- tricles, and above the corpus callosum, just involving the calloso-margi- mal convolutions. On the left side the track was sharply defined, and formed a cavity five-eighths by seven-eighths of an inch in diameter Con- taining the ball surrounded by clot and brain detritus. This was separated by the median fissure from the cavity on the right side, from which the bone was extracted during life. Between the two cavities was a minute piece of bone. STUDY OF INJURIES OF THE HEAD. 303 CASE LXXIX. Female, eight years of age; fell three stories; conscious; shock; compound comminuted depressed fracture of left frontal bone, with laceration of brain and meninges; restless and delirious; died on the third day; temperature on admission, 100:2°; rose to 104.6°. Necropsy.—Cavity in left pre-frontal lobe filled with clot and brain detritus. No considerable intracranial haemorrhage. General contusion of brain substance with coagula in minute vessels. CASE LXXX. Male, fifty years of age ; cause of injury unknown ; un- conscious; pulse and respiration rapid ; temperature, 100°; both pupils dilated ; died in four hours. Necropsy.—Simple fracture of left temporal bone, squamous portion. Deep laceration of right temporo-sphenoidal lobe, also of anterior border of left temporo-sphenoidal, smaller and shallower. Whole superior surfaces of both hemispheres covered by cortical haemorrhage. CASE LXXXI. Male, sixteen years of age ; struck on the head by an iron wrench ; scalp wound ; depressed fracture at right parieto-occipital junction ; trephined and elevated ; no general symptoms; walking case ; no injury of dura ; no subsequent symptoms. CASE LXXXII. Male, thirty years of age; struck on the head ; com- pound depressed fracture of left temporal bone at parietal junction ; tem- porarily unconscious ; afterward dazed ; agraphia. Trephined and bone elevated next day ; agraphia continued eight days; sensory aphasia on the third day. Temperature on admission, 99°; next day, 103°; second day, 103-8°; became normal on eighth day; afterward varied from 99° to 102°; for twenty days; did not again become normal till thirtieth day. CASE LXXXIII. Male, thirty-three years of age; blow from a cleaver; fragment of outer table of left frontal cut off and left hanging by the periosteum, including the frontal eminence; condition irritable; wound healed in four days; no subsequent symptoms. CASE LXXXIV. Female, two and a half years of age; fell down stairs; Compound depressed fracture of left parietal bone just posterior and external to frontal eminence ; wound lacerated and contused. Three days later, convulsion occurred, and she was admitted to hospital. Wound Suppurating and sloughy. No general symptoms. Bone elevated. Highest temperature, 102°. Discharged in twenty-eight days; readmitted fourteen days later; subdural abscess; hernia cerebri; abscess in brain °Vacuated ; hernia subsided, and patient discharged. CASE LXXXV. Female, forty-two years of age; struck with a ham- * Weighing eight pounds; several lacerated and contused wounds of the Scalp, and a depressed fracture of the posterior inferior part of the *ight parietal bone one-half by three-fourths of an inch in diameter, with a fissure running forward ; haematoma over right malar bone and a contu- Sion of the back of the neck; patient conscious, rational, and restless; 304 NEW YORK STATE MEDICAL ASSOCIATION. pulse, 120 and full ; temperature, 99°; third day, 100°; fourth day, 104°. Trephined and elevated ; some epidural clot removed ; dura tense and not pulsating, and was incised ; small amount of blood and serum escaped ; wound healed at once, and temperature fell gradually to 99° in the next four days. Six months later, I was told by Dr. S. Douglass that he had seen her at about that time. She was very nervous and excitable, and complained that she was confused and “wrong in her head" ever since her discharge. CASE LXXXVI. Male, thirty-eight years of age ; was struck by a bottle in middle of forehead ; he was dazed, but able to walk; compound depressed fracture of right frontal bone extending into orbital plate, and frontal sinus opened. Trephined and a piece of bone, an inch and a half square, with a sharp edge, which had penetrated the cerebral substance, was removed. The superior longitudinal sinus was torn, and haemorrhage was controlled by pressure against the bone with one blade of a Langen- beck's forceps. Sutured in position till the third day. The patient for a time was irritable and delirious, requiring mechanical restraint. The temperature was very uniform, varying only from 99% to 100°, when it became normal. CASE LXXXVII, Male, forty years of age ; knocked down by a blow upon the head. When he recovered consciousness he walked into the hospital. Compound depressed fracture posterior to left frontal eminence, and piece of inner table driven in. Dura uninjured. No general symp- toms. Temperature, 101° to 102” for six days, when it suddenly dropped from 101° to normal. CASE LXXXVIII. Male, fourteen years of age ; fell two stories; tem- porarily delirious from fright and excitement, and then recovered and walked home ; depressed fracture in right frontal bone near coronal suture; elevated ; no subsequent symptoms. CASE LXXXIX. Male, thirty years of age; gunshot fracture of right frontal, one inch above the zygoma, ; considerable haemorrhage from wound and beneath the conjunctiva; right eye protruded so much that the lids could not be closed ; no mental symptoms; temperature, 99.5° to 104.5"; next day temperature 104°. The bullet-opening in the skull was enlarged by the trephine, several loose pieces of bone removed, and the bullet felt near the optic foramen. The eye was then removed and the bullet CX- tracted through the orbit, the dura having been first incised. The roof of the orbit was found to be much comminuted. Temperature remained high, and delirium and illusions continued for three days. The wound suppurated rather freely for the first month, and the patient often suffered from headache, which was always relieved by changing the dressings. He remained in the hospital for two months and was then discharged entirely well. The temperature for the first ten days was 102” to 103°; for the next twenty days, 100° to 101°; for the next ten days, 100°; and the next ten days, 99° to 99"—H·. - STUDY OF INJURIES OF THE HEAD. 305 CASE XC. Male, eighteen years of age; blow upon the head from a hammer ; conscious; compound fissured fracture in left parietal region ; no depression ; no Symptoms. CASE XCI. Male, twelve years of age; ran into an iron post ; compound depressed fracture of right frontal bone, encroaching upon coronal suture in temporal region ; slight escape of brain-substance; elevated piece of bone three-quarters of an inch in diameter; no general symptoms of cere- bral injury. Had no subsequent symptoms, except for a single day fol- lowing the operation, when he responded slowly to questions. CASE XCII. Male, thirty-five years of age ; blow upon the head from an earthen mug ; compound fissured fracture of external table of posterior part of left parietal bone; no general symptoms. CASE XCIII. Female, thirty-seven years of age ; struck by a brick falling from a roof; compound depressed fracture of right parietal bone, three-quarters of an inch from median line, double comminuted. One fragment removed and the other elevated. No general symptoms either before or after the operation. CASE XCIV. Male, sixteen years of age ; thrown from a horse ; com- pound depressed fracture of left frontal bone, just above superciliary ridge; conscious and irritable ; temperature, 99.8° ; pulse, 60, full. A piece of bone, an inch and a quarter by half an inch, completely separated and driven in upon the dura, was elevated and removed under ether. Had no Subsequent general symptoms except temperature, which for ten days Was usually from 99° to 100°, and a somewhat irritable mental condition. CASE XCV. Female, seven years of age ; fell one flight of stairs over the banisters; struck her head ; unconscious; vomited. Became dull and stupid on the second day; next day admitted to hospital. Haematoma in left parietal region, and linear fracture, discovered by incision, confined to left parietal bone. Temperature, 99°. No subsequent symptoms. CASE XCVI. Male, thirty-two years of age; stabbed in the forehead With a pocket knife. Three days later no general symptoms. Tempera- ture, 99" to 100° ; pulse, 76. After incision, the knife blade could be seen broken off at the level of the surface of the bone, an inch and three-quarters above left supra-orbital ridge, and an inch and a half to left of median line. A button of bone, which included the knife point in the centre, was re- moved by the trephine. The point had penetrated the brain a quarter of * inch. Dura incised and closed by suture. No subsequent symptoms. CASE XCVII. Male, twenty years of age ; knocked down by a blow from a heavy stick ; unconscious; linear fracture from just above left *P*ciliary ridge, extending into parietal bone, and incised wound. No 8°neral Symptoms. CASE XCVIII. Male, thirty-one years of age; struck by a shower of bricks; Compound depressed fracture of right parietal bone. Trephined, *d loose fragment of inner table, half an inch square, removed. No 8°neral symptoms, 20 306 NEW YORK STATE MEDICAL ASSOCIATION. CASE XCIX. Male, twenty-six years of age; fell thirty-five feet from a scaffold; had been temporarily unconscious. A fragment of the right parietal bone, near its upper posterior angle, including both tables, had been torn out and was missing, two inches by one inch and three-quarters in diameter. The inner table was comminuted, and fragments pressing upon the dura were removed. No fissures. Dura uninjured. No disorders of sensation or other general symptoms. Temperature, 99° to 100°-H. CASE C. Female, forty-five years of age ; fell down stairway at elevated railroad station ; unconscious. Admitted after five days. Haema- toma over left eye, which had been incised ; fissure, extending into frontal sinus, could be detected through the incision. The only general symptom was occipital headache for some days after the injury was received. CASE CI. Male, eight years of age; kicked by a horse; compound depressed fracture of right frontal bone, just above frontal sinus and near the median line. Elevated on the fourth day. Dura uninjured. Opening in the skull which remained was three-quarters of an inch in diameter. Had no previous general symptoms. Temperature, from 99° to 99.8°; after the operation, rose in twenty-four hours to 108°, and in forty-eight hours to 104°. In the next five days it fell gradually to 99° and remained 99°–H for ten days following. Once during this time—on the fifteenth day— some serum escaped from the wound at the time of dressing. On the twen- tieth day some laudable pus escaped, also at the time of dressing, and a probe was carried two inches and a half into the frontal lobe parallel to the orbital plate. The next day the dura was incised to the extent of the cranial opening, and from two to three ounces of laudable pus evacuated. The probe could be carried backward two inches and a half parallel to the cranial wall on the external aspect of the hemisphere, as well as two inches and a half parallel to the orbital plate. The temperature at this time was 99.2° and pulse 96. There were no general symptoms, except a little mental dullness or apathy and slight right lower facial paralysis. His general con- dition was also becoming asthenic. The cavity was irrigated and drained by tube. Temperature rose next day to 102°– ; became normal in a week. Facial paralysis entirely disappeared in ten days. Discharge ceased during the third week. Mental condition became normal, and nutrition rapidly improved after the first few days. There was a fungus, not larger than a hazel-nut which spontaneously disappeared. The external wound Was entirely healed in little more than a month, and no symptoms of any kind remained. INJURIES OF THE ENCEPEIALON. CASE CII. Male, forty-one years of age; fell upon his face; contusions most marked on left side of face and eyes; violent delirium for two days. Temperature, 103° to 104°. On the sixth day again became delirious, and later unconscious and violently responsive to irritations. Temperature was at no time below 100°, and was 103° just previous to death, which occurred at the end of six days. STUDY OF INJURIES OF THE HEAD. 307 Necropsy.—Haematoma and small scalp wound in right parietal region. Thin cortical coagulum over left occipital lobe, extending into median fis- sure. Subarachnoid serous effusion. CASE CIII. Male, sixty years of age; pushed down three steps of a stairway, and sustained minor superficial injuries. No head symptoms till the fourth day, when he had four convulsions. There was one the next day, and afterward they occurred with increasing frequency till his death on the eighth day. Each one began by twitching of the muscles of the face, with the head and eyes turned to the left, and these extended to the left arm and finally to the left hand. The right side was not involved at all. Temperature on admission, 100°; in twelve hours, 103°. From this time it varied from 103° to 104° till six hours before his death, when it became and continued 105°. Mecropsy.—No lesion of scalp or skull. Subdural haemorrhage over whole right cerebrum, and extensive laceration of right temporo-sphenoidal lobe. CASE CIV. Male, thirty-two years of age; fell upon the sidewalk; scalp wound in left occipito-parietal region. Admitted to hospital ten hours later. Conscious and rational, but dazed, and with extreme muscular tremor. Two hours afterward the patient had a general convulsion. From this time, during periods of about six hours, there would be a suc- cession of convulsions, with intervals of unconsciousness or delirium, fol- lowed by an equal period during which he would remain quiet and rational. The convulsions were all general from beginning to end, without recog- nisable initial symptom. Died in two days. Necropsy.—Scalp wound, as previously noted. No lesion of skull. Cortical haemorrhage on the right side of the vertex, from anterior border of frontal lobe to posterior fissure of Rolando, and covering the temporo- Sphenoidal lobe laterally and at the base. Deep laceration of right frontal lobe, through the cortex, upon anterior and lateral borders, and extending Well into the parietal region. CASE CV. An unknown man was found in the street, leaning against a fence in an upright position, dead. Necropsy.—Haematoma over right side of the vertex; no lesion of the skull; blood fluid and viscera generally much congested; area of contusion and laceration over greater part of left frontal and temporo-sphenoidal lobes; subdural haemorrhage over whole left hemisphere. CASE CVI. Male, thirty years of age; found unconscious, and sup- Posed to have jumped or fallen from a second-story window. Wound over right eye and fracture of the nasal bones; coma profound ; stertor; pupils contracted. On the two following days the temperature rose pro- gressively from 101°-H on admission to 104.5°; pulse full, respiration rapid. Patient could be roused by pressure on supraorbital nerve. On the third day still deeper Coma, dysphagia, continued irritability, and restlessness, *d temperaturestill 104.5°. Death at end of four days; temperature, 107-4°. 308 NEW YORK STATE MEDICAL ASSOCIATION. JMecropsy.—No lesion of skull; no meningeal lesions; small cortical haemorrhage over posterior part of left parietal lobe, and small laceration of brain at parieto-occipital junction ; both cerebra hyperaemic. CASE CWII. Male, forty years of age; fell down stairs. Admitted to alcoholic ward and transferred to surgical service next day. Slight scalp wound above right ear; comatose, but later could be roused sufficiently to tell his name ; temperature, 103°4°; restless ; hyperaesthetic ; pneumonia discovered ; died next day. - Necropsy.—Left lung pneumonic ; lower lobe in second stage, upper lobe in first stage ; no lesion of the skull; dura mater adherent to the calvarium ; the left hemisphere on its upper surface was completely covered by an organised false membrane, which also dipped into the median fissure and covered its internal surface. This membrane was divisible posteriorly into two layers; it was thin anteriorly, but fully an eighth of an inch in thickness in its posterior part ; its upper surface was smooth, non-adherent, and comparable in appearance to a section of raw beef; its inferior or cerebral surface was smooth, velvety, non-adherent, and could be raised without injuring the arachnoid ; it did not dip into the sulci ; it was traversed by minute vessels and studded with some fifteen or twenty grayish, caseous, and partially calcareous nodules, vary- ing in size from that of a robin-shot to that of a buckshot. Similar nodules were found in the basilar vessels, which were generally atheroma- tous. No recent lesion of the brain was discovered, except general con- tusion indicated by moderate hyperaemia and some capillary extravasa- tions. - His wife subsequently stated that he had never lost a day's work by reason of sickness, and that he had never had even temporary loss of con- sciousness or paralysis. CASE CVIII. Male, fifty-seven years of age ; fell from his cab ; un- conscious; large haematoma over left parietal region; respiration slow and stertorous; double facial paralysis and cheeks flapping; complete right hemiplegia and anaesthesia ; temperature, 99°. Trephined over left motor area; dura pale, tense, and bloodless; no brain pulsation. After incision of dura, serum escaped freely, and the quantity increased when the head was so turned as to drain from the base. No blood clot found, Tempera- ture at time of operation had risen to 103.4°; six hours later it had fallen to 98-6°. The patient had regained consciousness and could articulate, and gave his name and address. Hemiplegia not relieved. After twelve hours, pulsation in the brain returned and he could speak rationally and intelligently, though with difficulty. Two hours later still, he had a slight convulsion, and death followed in four hours. The temperature remained at 98.6° after the operation for fourteen hours, and it then rose steadily to 104°6° just previous to death. The lower face continued para- lysed and the respiration became frequent and insufficient. Necropsy.—No lesion of skull; laceration of external border of right cerebellum anteriorly, from which clot had formed about circle of Willis STUDY OF INJURIES OF THE HEAD. 309 upon anterior part of pons and in transverse fissure in front of left cere- bellum ; the vessels were atheromatous ; the interior of the left occipital lobe was filled with clot which had completely broken down its structure ; the left lateral ventricle was filled with blood which had broken through the septum into the right lateral ventricle and also communicated with the blood cavity in the occipital lobe. CASE CIX. Male, sixty-three years of age ; struck by some part of the machinery of his engine ; no general symptoms; temperature, 100°; wound in posterior parietal region in median line and curving to the right ; contusion over left parietal eminence ; temperature second day, 103.2° ; delirious in the night; temperature third day, 101.8° to 101°; headache; fourth and fifth days, temperature, 103.4° to 103°; no general symptoms; sixth day, temperature, 106’4”, pulse, 140; restless and irritable, but rational; weaker; died on the eighth day; temperature last two days from 105° to 105'2°; post-mortem temperature, 104°. A few hours pre- vious to death there was muscular rigidity of all the extremities, most marked on right side and especially in right arm. There was perforating ulcer of the cornea. Mecropsy.—No lesion of skull or meninges; no haemorrhage; no lacera- tions; cortex of brain and meninges hyperaemic ; brain substance moder- ately oedematous and minute vessels filled with coagula; this condition involved corpora striata, optic thalami, pons, and cerebellum, and was most pronounced on left side and at the base; no minute extravasations; both lateral and both inferior petrosal sinuses were filled with decolorised thrombus, extending into jugular vein on the right side; the thrombus Was colored only near the torcular Herophili. CASE CX. Male, sixty years of age ; fell two stories to the sidewalk. Contusion of left eye and slight contusion just above it ; temperature, 101'4”; delirium ; pupils and respiration normal; pulse, 114. Later symp- toms: patient very irritable; cried out and tried to getaway when touched, but replied rationally to questions; incontinence of urine and faeces; delirium continued; died on the fifteenth day; temperature rose to 103.2° On the fifth day and then fell very gradually to 100°. The day before death it was 103.4°, was 103.8° five hours ante-mortem, and 104.2° one hour post-mortem. General symptoms remained unchanged. Wecropsy.—No fracture; subarachnoid haemorrhage over both hemi- Spheres, forming a sheet which was thickest about occipito-parietal junc- tion on both sides; some subarachnoid serous effusion in left frontal region; 8èneral contusion, which was most marked on left side; hyperaemia and punctate haemorrhages. CASE CXI. Male, forty-five years of age; cause of injury unknown; found unconscious in the street and admitted to hospital after forty-eight hours; contused wound in right parietal region ; muttering stupor; rigidity of left arm; right hemiplegia, which was incomplete, but most marked in *ight arm; pulse, 60; temperature, 101*. On the third day the rigidity of the left arm was increased, and the paralysis of right arm was complete; 310 NEW YORK STATE MEDIOAL ASSOCIATION. paralysis of right leg was nearly so; coma absolute; pulse, 128; tempera- ture, 105°. Trephined over motor area and incised the dura. Pulsation of brain absent at first, but soon returned in some degree. His movements became freer, and he began to utter articulate sounds. Signs of sensibility increased ; pulse, 108; temperature still 105°. Died next day. Mecropsy.—Moderate subacute arachnitis over anterior two-thirds of upper surface of right cerebrum ; laceration of left temporo-sphenoidal lobe, excavating and filling with clot its whole interior structure. The haemorrhage extended downward around the circle of Willis and upward upon the cerebrum, mainly upon the occipital, but also in patches upon the frontal and parietal lobes. CASE CXII. Male, sixty years of age; found unconscious in bed ; seemed to be in perfect health when he retired to his room on the previous evening. He was heard moaning; no evidence of injury could be dis- covered ; stertor; pupils normal; rigidity of right side ; pulse 120 and weak; temperature, 100°. On the next day the right side was less rigid ; the second day he was comatose; temperature, 103°2°, and he died. Mecropsy.--No lesion of scalp or skull ; large amount of serum under the arachnoid. There was a very soft elliptical area of disintegrated brain tissue an inch and a half by three-quarters of an inch in diameter upon the anterior part of the left occipital lobe, near the median fissure. There was a similar area, smaller in size, on the under surface of the same lobe, but with disintegration less advanced, and containing a clot not yet decolorised. There was a red, firm clot beneath the latter, and deep in the substance of the cerebellum, of more recent formation. The temporal artery was ather- Omatous, but none of the basilar arteries was diseased. CASE CXIII. Male, thirty years of age ; fell down stairs; conscious- ness was lost, and only partially restored. He fell out of bed that night, and again the next day, striking each time upon his right side. Admitted to hospital that evening. No external evidence of injury except slight contusion over crest of right ilium. Rational, but slow to respond to questions; left pupil slightly dilated ; temperature, 99°. The follow- ing day he again fell out of bed, and again the day after, always on the right side, and there was a constant tendency to move to the right side of the bed, which was quite level. Some left paresis and some difficulty in Swallowing, which he referred to the left side of the throat ; transient facial paresis. The amount of paresis and the condition of the left pupil varied from day to day. His mental condition deteriorated ; he was stupid, rambling in talk, delirious, apathetic, and had delusions. At first urine, and later facces, were voided unconsciously. His temperature for ten days was 99%+; it then began to rise and was 100°-|- to 101°; pulse usually from 84 to 96, and respiration nearly normal. On the fifteenth day he was trephined Over the right motor leg area, and a small subcortical cavity dis- covered, from which half a drachm of yellowish fluid was removed. This fluid was subsequently found to contain numerous leucocytes. There was no marked change in his symptoms after the operation. Temperature was STUDY OF INJURIES OF THE HEAD. 311 a trifle lower—99° to 100°–till the eleventh day, when it rose to 104°, fell the next day to 100°, and rose again to 104°, when he died from asthenia on the twenty-eighth day after his admission. Necropsy.—Large subarachnoid serous effusion compressing frontal lobes. General cerebral hyperaemia and many minute vessels filled with coagula. The brain substance around the Small cavity discovered during life was softened, stained a reddish-gray color, and it contained minute extravasations. CASE CXIV. Male, twenty-nine years of age ; was found unconscious in Central Park. He was taken to a hospital, sent to court charged with intoxication, and afterward admitted to Bellevue, still unconscious. Small contused wound in right frontal region ; pupils slightly dilated ; complete left hemiplegia and hemianaesthesia ; slight left facial paral- ysis; temperature, 106°; pulse, 140; respiration accelerated ; convulsions shortly after admission, which were repeated at frequent intervals; initial symptom on the mouth and face ; arms and legs gradually involved ; trephined over junction of right arm and leg areas by house surgeon; result negative ; temperature two hours later, 107.4°, and three hours later still he died in a convulsion. The ventricle was aspirated in the operation ; temperature forty-five minutes post-mortem, was 109.4°. Necropsy.—Brain and meninges excessively hyperaemic ; a small tumor as large as a pea was found in right lower face area; the surrounding brain tissue was disintegrated, forming a small cavity; no haemorrhages; tle viscera were generally soft and congested. CASE CXV. Male, thirty-seven years of age ; was found at the bottom of a stairway with his feet uppermost ; unconscious; pupils contracted ; muscular rigidity, especially marked in the legs; pulse rapid ; stertor; died in two days without having regained consciousness. CASE CXVI. Male, twenty-six years of age; thrown out of a wagon and struck his head ; unconscious, but conscious on admission; contusion in left parietal region; became irritable, and later comatose; died sud- denly five hours afterward. CASE CXVII. Male; struck by a cleat falling from aloft aboard ship; large haematoma covering whole right side of the head; unconscious; slight rigidity of left side; pulse full and slow ; died in fifteen minutes after admission. CASE CXVIII. Male, thirty-two years of age; struck with a shovel; Contusion of the right posterior parietal region; pulse full and slow ; tem- perature, 100°; pain in back of the head; dilatation of left pupil; rigidity of flexor muscles of the arms; somnolence and restlessness. After twenty- four hours patient became stupid and mildly delirious ; left pupil widely dilated; urinated unconsciously; left arm only moved when irritated ; Sensation slightly more acute on right side; dysphagia marked; left pupil irresponsive to light. His condition varied from time to time for the first *W9 weeks; left pupil more or less dilated and more or less irresponsive to 312 NETW YORK STATE MEDICAL ASSOOIATION. light; mind obscured and apathetic ; some ptosis of left eye. After that time his mind became clear, and he could intelligently describe the man- ner in which he received his injury. Paralysis of the left external rectus; optic nerve and retina normal; perforation of left tympanum and puriform discharge; some left facial paralysis. He was discharged at the end of two months. His ptosis and external strabismus had disappeared, and there was only a perceptible trace of the paralysis of the lower face. His left hemiparesis and anaesthesia were no longer noticeable. He was dull and stupid, which his family said was his normal condition. CASE CXIX. Male, twenty-five years of age ; fell from a truck, strik- ing his forehead ; unconscious for twenty-four hours; slightly delirious for two days; pain in frontal region after that time; temperature, 100°, followed by mild dementia, which continued till his discharge. CASE CXX. Male, twenty-one years of age; fell sixty feet down an embankment; unconscious; afterward, violent delirium lasting a week; then admitted to the hospital, still delirious, but more quiet ; suppurating scalp wound external to right frontal eminence ; bone exposed ; also double fracture of right inferior maxilla. The following day he had eleven epilep- tiform convulsions within two hours. Each one began with twitching in right hand and arm, extending to left arm and then to both legs, and finally a general convulsion was established. Face not much involved, but eyes deviated to the right. After these attacks he remained unconscious for one hour; the right arm was then found to be anaesthetic, and with the right leg paretic. The next day he had one similar attack, but he was more rational afterward and recognised his paretic condition. On the next day he had six convulsions within a little more than two hours, each one beginning on right side of the face and extending to right side of the body before becoming general, and the right arm was paralysed for five minutes afterward. In the next few hours he had six others, one of which was confined to right side of the face. He was then trephined over left face area and the opening freely en- larged. Dura tense and incised, but no lesion discovered. He was then trephined through the exposed bone on the right side without result. No further convulsions occurred. The next day he was entirely rational, and it was discovered that he was aphasic. Some difficulty in articulation pre- vious to the operation was ascribed to the fractures of the jaw. He had both motor and sensory aphasia. Called his own name McNannold. He was discharged at the end of a month. His wounds were entirely healed, right arm still paretic, and mind clear. He had some hesitancy in Speech, and the selection of words required a little time. His temperature ranged from 99% -- to 101° during his whole convalescence. CASE CXXI. Male, twenty years of age; cause of injury unknown ; unconscious for a short time; scalp wound in left parietal region near the mesial line, and a large haematoma just behind it in posterior parietal region. He had no general symptom, except nearly complete paraplegia with flaccid muscles and somewhat increased reflexes. There Was no STUDY OF INJURIES OF THE HEAD. 313 evidence of specific disease, and it was possible to verify the fact that no paralysis had existed previous to this recent injury. He was discharged at the end of six weeks and could walk fairly well. The diagnosis was corti- cal haemorrhage from direct contusion of the brain, extending from left motor leg area across the median line into the corresponding area on the right side. CASE CXXII. Male, twenty-one years of age ; cause of injury un- known ; found unconscious. Committed as drunk and disorderly, and sent to Bellevue as a case of alcoholism. He again became unconscious and was constantly crying out, but always a single phrase. He was rest- less and hyperaesthetic, and the muscles of both sides were generally rigid. There was a slight Scalp wound in right temporal region; incision dis- closed no fracture. The day following he was more quiet and the muscles were less rigid. Partial paralysis of the lower left face was developed. He became rational, but apathetic. Then there were two days more of active delirium, after which he again became quiet, but had delusions. He was coherent in speech, though voluble, loquacious, and silly. He had Sensory aphasia and agraphia, and his memory of recent events returned ; he thought, however, he was born in September, 1891—two months before. In notation, at dictation, he interpolated figures, thus—in writing 495, he wrote 490005. He could write two figures correctly, but not more. After his discharge he returned to the hospital some months later, and was noisy and excitable. Subsequent inquiry at the station-house made it probable that he was not intoxicated at the time of his arrest. He remained unconscious from early evening all night. When he was finally roused he made strenuous efforts to speak. He was only able to say “Peter,” his first name, which he repeated again and again, and evidently strove to give his last name. Temperature, 100:2° on admission ; from 100° to 101° for five days, then normal. After that time averaged 98.5° to 99.5°. CASE CXXIII. Male, twenty-one years of age; cause of injury unknown ; found unconscious in the street ; contusion of left eye and Wound over superciliary ridge. On admission, he looked about with a Vacant stare, but could not be induced to speak. Next day he had delu- Sions and failed to recognise his family. His subsequent symptoms were all mental. Memory of recent events lapsed. Never spoke except when disturbed, then answered questions intelligently but mechanically. For three nights he became violently delirious, and attacked his neighbor in the next bed; then he became quiet again, and began to manifest some in- terest in what passed about him. Two weeks from the time of his admission his condition suddenly improved, and he began to remember Some things which immediately preceded his injury. For the ensuing two Weeks it was mainly noticeable that he never suggested or carried on any Sustained conversation, and that he laughed much and without due cause * the next and final two weeks of his continuance in the hospital, he *sed to laugh inordinately or causelessly, and his memory seemed to be restored in reference to matters up to the time he was hurt, and since his 314 NEW YORK STATE MEDICAL ASSOCIATION. recovery of consciousness. The only abnormal indication in his appear- ance was a slightly weak expression in his face. Temperature on admission, 99.2°; afterward from 99° to 101°. CASE CXXIV. Female, seventeen years of age ; fell three stories through a hatchway; contusion of left occipital region; no fissure found on incision. She was unconscious, with muscular rigidity of all the ex- tremities, and was irritable when disturbed. She moved the right arm and left leg only. Temperature, 100:2°. Delirious on the fourth day, and noisy and excitable for several days afterward. There was left paresis and dilatation of left pupil on the tenth day, and at the same time incontinence of urine and faeces which continued eight days. Temperature was 100°–H for the first five days, 99° – for next five days, and then became normal. It rose on the thirteenth day from 99% to 103°5°, and on the next day to 104.5°. For the next ten days it was usually from 102° to 103°, at which time she was removed from the hospital. She subsequently recovered. She was of bad constitution, had inherited syphilis, was deaf, and had interstitial keratitis in both eyes, with loss of sight in one from opacity of COI’Ilea. The following cases of idiopathic lesion are added to illustrate simulated traumatism : a. Male, fifty-five years of age ; fell upon the sidewalk, and, after rising and walking a short distance, fell again. Upon admission he had a small wound in the median line of the frontal region. He smelled strongly of Spirits and was ascertained to be of intermperate habits. He was uncon- scious from the time he fell until he died, seven hours later. He was rest- less, and upon irritation had muscular spasm of both lower and upper extremities. He had incontinence of urine and faeces, dilated pupils, and Cheyne-Stokes respiration. No paralysis. , Temperature, 103.4°, 104°, and 105°. It was subsequently learned that the scalp wound was received two days previously, and that the spirits of which he smelled so strongly had been spilled upon him in an effort to restore him to consciousness before admission. Necropsy.—Chronic meningitis with great arachnoid opacity, but no serous effusion. Basilar arteries extremely atheromatous. Both lateral ventricles enormously distended with very bloody serum. Clot extended through each posterior cornu. The right optic thalamus was swollen with clot which also filled the third ventricle. b. Male, seventy-one years of age ; said to have accidentally fallen from a chair four days previous to admission ; no loss of consciousness; Subse- quent delirium ; required mechanical restraint till his death, twenty-four hours later; pupils contracted ; posterior cervical muscles rigid ; hyper- aesthesia; retention of urine; temperature, 102°, 102°,+, 103°; pulse, 90 to 114. Necropsy.—Abrasion of the nose. Duramater adherent to the calvarium, and arachnoid to the brain. Little serous effusion. Some opacity of the arachnoid. Meningeal and cerebral vessels hyperaemic. Cortex softened. STUDY OF INJURIES OF THE HEAD. The result of an analysis of the preceding cases may be expressed in a brief SUMMARY. I. Fractures of the Base, - - sº Recovered, - - – 21 Died, gº - - - 49 Number of necropsies, - sº mºs II. Fractures of the Vertea, -*. - Recovered, * - – 21 Died, - tº- - - - 10 Number of necropsies, - - III. Encephalic Injuries without Fracture, - Recovered, - - - - 7 Died, a- --> - - 16 Number of necropsies, - * . - Total number of recoveries, - - 49 © ( & 4 { % deaths, - - 75 Total number of necropsies, - INECTROPSIES. I. Fracture of the Base. Involving posterior fossae, - 6 & middle fossae, - - middle and anterior fossae, middle and posterior fossae, anterior and posterior fossae, all fossae, - - Total number involving middle fossae, & 4 & 4 “ posterior fossae, anterior fossae, Complications. Laceration and resulting haemorrhage, { % “ general contusion, - meningeal contusion, & 4 & 4 { % { % & 4 124 70 35 31 10 23 13 58 sº : cº • * * * * & 3.16 NEW YORK STATE MEDICAL ASSOCIATION. Laceration and thrombi, haemorrhages, - 2 { % “ epidural haemorrhages, - 6 { % “ meningeal contusion, epi- dural haemorrhages, - 1 { { “ general contusion, epidural haemorrhages, - 1 Contusion and abscess, s - - 1 General contusion and epidural haemor- rhage, * - * - 2 Meningeal contusion, - * - 1 35 From direct violence, - ºm - 31 “ contre-coup, - sº - 4 II. Fracture of the Vertea. Involving frontal bone, sº - 4 C & parietal bone, - tº- - 1 { % occipital bone, - - 1 & 6 parietal and occipital bone, - 1 ( & parietal and frontal bone, - 1 € 4 temporal bone, - * - 1 * 9 Complications. Laceration and resulting haemorrhage, - 5 “ “ general contusion, - 2 { % “ atrophy, * - 1 “ meningeal and general contusion, 1 General contusion and epidural haemor- rhage, * - tº - 1 10 III. Injuries of the Encephalom, without Fracture. Varieties. Laceration and resulting haemorrhage, - 5 { % “ meningeal contusion, - 2 ( & ‘‘ general contusion, - 1 Meningeal contusion, - tº - 1 General contusion, - - - - 2 STUDY OF INJURIES OF THE HEAD. 317 General contusion and thrombi, - <--> & 4 and meningeal contusion. - <--> In Fifty-eight Wecropsies. Laceration and resulting haemorrhage, - & 4 { % © ( & C { % “ general contusion, - sº “ meningeal contusion, * “ epidural haemorrhage, - thrombi, and haemorrhages, sº general, and meningeal contu- Sion, *-*. - - and atrophy, sº - * meningeal contusion, epidural haemorrhage, - - General contusion, -- - Meningeal contusion, - * = General contusion and epidural haemor. rhage, General contusion and thrombus, - - { % C & ‘‘ meningeal contusion, Subcortical contusion and abscess, - - Total number of cases in which injury was received by Contre-coup alone, gº * *-*. Direct violence alone, sº – * Contre-coup and direct violence, - * Unknown, wº- -> º Unrecorded, $º - º * Pseudo-injuries. Apoplexy, . ** * º Arachnitis, - *E* sº | 1. :3 : : 10 : : 318 JNETW YORK STATE MEDIOAL ASSOCIATION. In the majority of instances the subjects were males in adult life. Vocation, the blundering helplessness of ine- briety, and the homicidal passion, sufficiently account for the influence of age and sex in the production of these injuries. Fractures.—It is a noteworthy fact that so many in- juries of the head—nearly sixty per cent.—involve frac- ture at the base. I have ranked as basic fractures all those which have involved that region, even though be- ginning at the vertex, because it is upon the implication of the base that all the so-called characteristic symptoms depend. In fact, fractures of the skull which do not begin at the vertex are exceptional. I have found upon necropsic examination but four cases in which fracture at the base was not continuous with a fissure extending from the point upon the vertex at which the violence was inflicted. These four, which began and ended in the base, were evidently from contre-coup. That they were the result of violence acting directly upon the ver- tex was proved by the history of the injury, as well as by existent wound, contusion, or fracture. In neither one was there the slightest reason to suspect that the force was transmitted through the spinal column. The greater frequency of fractures which extend to the base, when compared with those which are confined to the ver- tex, depends simply upon the fact that, under ordinary circumstances, the physical properties of bone are such that force, even when of crushing character, will not expend itself wholly upon the point of impact, but will extend to a considerable distance. That the fissure extends from vertex to base, and not from base to Ver- tex, is proved, even in the absence of a history, by the mute evidence of the superficial injury, and by the nar- rowing of the fissure as it passes downward. The ex- planation of the fact that fracture through the middle is more frequent than through the other fossae is equally simple. The experiments of Aran have shown that when any part of the vault is subjected to violence it is the STUDY OF INJURIES OF THE HEAD. 319 corresponding part of the base which suffers. It follows that the central or parietal region is the one most ex- posed to violence, and it is corroborated by the results of post-mortem examination. Four cases, aside from those produced by contre-coup, are of special interest simply as fractures. The first is a separation of the temporal bone into its constituent parts —squamous, petrous, and mastoid—in an adult male, the result of an apparently inadequate cause. The specimen was shown to this association two years ago. The second was a comminuted fracture of nearly the whole occipital, the posterior part of both parietal, and the right temporal bones, in which the fragments were com- pletely detached from each other. This, like the first, was occasioned by a fall in the street, and was accom- panied by extensive injuries of the brain, sinuses, and membranes. The patient recovered partial conscious- ness, and lived for a week’s time. The third involved all the fossae on both sides from a fall from the mast- head, and the patient survived two hours. This case I believe to be the first on record in which all the fossae Were involved in fracture. The fourth case was a wide Separation of the coronal suture on both sides, occurring in an adult without concomitant fracture. The most practical comment to be made upon fractures of the skull is that in themselves they are absolutely un- important. It is only by their complications, immediate Or remote, that they involve danger to life. COMPLICATIONS OF FBAOTURES. The complications of fracture are haemorrhages, thromboses, lacerations, contusions, and paralyses. Their derivatives are meningitis, abscess, and atrophy. All of these may be produced directly from injury to the en- 9ephalon without fracture, with the exception of one form of haemorrhage. If epidural haemorrhage ever 900urs without the intervention of fracture, I have never 320 NEW YORK STATE MEDICAL ASSOCIATION. seen it in necropsies, or had reason to suspect it in re- covering cases. Fractures of the skull without complication are not only without importance or consequences, but they are devoid of symptoms. A simple fissure of the posterior fossa would probably be unsuspected, for symptomatic cervical ecchymosis is of the rarest occurrence. A simple fracture of the vault is often overlooked in the absence of pressure symptoms. In fracture at the base, dis- placement of the fragment does not occur, or is insuf- ficient to occasion trouble, and when the patient sur- wives, union, of course, is without provisional callus. The very general existence of complications, however, often of the gravest character, has given fracture of the base vicariously both an importance and a symptoma- tology. The encephalic lesions which complicate fracture in- clude all those which occur independently, and there- fore may be considered at once, from a double point of view, as complications and as primary injuries. HAIEMORREIAGES. Epidural haemorrhage is perhaps the most character- istic complication of fractures. In moderate quantity from the Osseous or smaller meningeal vessels, it is the usual source of the diagnostic haemorrhages from the ears, nose, or mouth, and into the orbital and Subcon- junctival tissues. In large amount, and as a source of danger, it is derived from the larger meningeal vessels, notably from the middle meningeal artery. In at least two, and possibly four cases, it was the immediate cause of death. In a third, involving fracture at the base, life was saved by operation, although the clot removed measured four ounces and a half by volume. Such a case is in evidence that the brain-tissue is really suscept- ible of compression. STUDY OF INJURIES OF THE HEA D. 321 Subarachnoid or cortical haemorrhage is ordinarily derived from laceration of the cortical substance, and is often the direct cause of death, as well as of certain of the precedent symptoms. From a laceration at the base, whether of the frontal or temporo-sphenoidal lobe, it may cover the whole Superior surface of one or both hemi- spheres, and cause various localising symptoms which accompany or precede those of facial pressure. From a laceration of the occipital lobe or cerebellum, it may cause immediate death from compression of the medulla ; or the haemorrhage from the torn vessels of the brain, even in extensive laceration, may be insufficient to seriously modify symptoms or hasten the fatal termina- tion. A moderate amount of cortical haemorrhage from rupture of the vessels of the pia is also one of the results of meningeal contusion. Subdural haemorrhage I have found most frequently to depend upon rupture of the arachnoid and escape of blood from the meshes of the pia mater into the arach- noid cavity. In a smaller number of instances its source has been in the meningeal vessels. In a recent case there Was rupture of the dura mater, and the blood was of epidural origin. Cortical haemorrhage, however, is, of all others, the one most frequently encountered. The majority of lacerations reach the surface of the cortex, and superficial haemorrhage results. THROMBOSIS OF THE SINUSES. The occurrence of thrombi in the sinuses of the dura mater and base of the skull in three cases, under varying Circumstances, is not in all of them susceptible of ade- Quate explanation. In the first case, which, like the Second, involved fracture at the base, the posterior part of the skull was Subjected to crushing violence. There Was extensive epidural clot, large subdural clot which filled the right inferior Occipital fossa, and a firm cortical *ot beneath the seat of fracture surrounded by an in- 21 322 NEW YORK STATE MEDICAL ASSOCIATION. flammatory exudation. The surface of the posterior part of the right occipital lobe was softened and the seat of minute extravasations. There were small lacerations of the inferior surface of both frontal lobes, and one of con- siderable size in the right cerebellum, beneath the thick- est part of the subdural extravasation. The wall of the posterior part of the superior longitudinal sinus was infiltrated with blood, and the cavity occupied by a thrombus. A second large and partially decomposed thrombus was situated in the torcular Herophili, and ex- tended through the right lateral and petrosal sinuses into the jugular vein. In the second case a simple fissure extended from the right parietal bone into the posterior fossa, terminating in the jugular foramen. There was slight epidural and considerable subdural haemorrhage at the origin of the fracture. There were several lacera- tions in the anterior part of the brain, and on the left side the interior of the temporo-sphenoidal and frontal lobes was excavated and distended by a clot from a haemorrhage, which had also broken through into the lateral ventricles and occipital lobes and filled them with fluid blood. There was cortical haemorrhage at the base, which had surrounded the optic chiasm and extended to the anterior border of the pons. The thrombus occupied the torcular Herophili and extended through the lateral and petrosal sinuses into the jugular vein. In the third and final case there was no fracture, intracranial haemor- rhage, or laceration. There was, however, general con- tusion, with moderate oedema and distention of the minute cerebral vessels with coagula. This condition extended to the corpora striata, optic thalmi, pons, and cerebellum, and was most pronounced at the base and upon the left side. The thrombus was decolorised, and Occupied both lateral and both petrosal sinuses. It ex- tended into the right jugular vein, and was colored only near the torcular Herophili. I have detailed all the accompanying lesions, though I do not believe that they were all related to the formation of the thrombi. In the STUDY OF INJURIES OF THE HEAD. 323 first case the infiltration of the wall of the sinus points to its laceration by direct violence as the first step toward the coagulation of its contents. The portion of the sinus in which it began was, moreover, directly beneath the point at which sufficient violence was in- flicted to comminute the skull, to rupture its membranes, and to cause localised inflammation in connection with the haemorrhage. The surrounding inflammation might, at first sight, suggest an inflammatory origin, but the absence of inflammatory products in the sinus wall cor- roborates the view I have taken. It is more difficult to account for the thrombus in the second case. There is no positive evidence, but a possible clew exists in the termination of the fissure in the jugular foramen. It may be that some injury done to the vein led to the beginning of thrombosis at this point. It had no evi- dent relation to the other intracranial lesions which can aid in Solving the problem. In the third case, the throm- bus was the only localised lesion, and again a different and conjectural explanation must be sought. There was general contusion and general thrombosis of the minute Cerebral veins. It is impossible to assume either that Venous canals of such size should have primarily par- ticipated in the effect of a general contusion, or that the obstructing coagula should have extended secondarily into the sinuses. It might more naturally be assumed that the thrombus, which was already decolorised, was an antecedent lesion which had led to the venous obstruction and oedema of the brain tissue. There was, however, no indication of previous disease, and the man Was at his work when struck down by the blow which Caused his death. These cases are pathologically in- dependent of each other, and may have no significance * Symptomatology or treatment. In another case I Suspected thrombosis of the internal jugular vein, on *Count of an oedema of one side of the face and neck, but his recovery precluded a confirmation of my suspi- ClOI). * 324 NEW YORK STATE MEDICAL ASSOCIATION. I am unacquainted with any similar instances of trau- matic thrombosis of these sinuses. They were uncon- nected with pressure or any inflammatory process within or without their walls, or with any dyscrasia of the pa- tient. In the first and second cases I have been able to suggest an explanation ; in the third case I am still with- out definite Opinion. LACERATIONS. Lacerations and contusions of the brain are unques- tionably first in frequency and importance among all the injuries of the head. They play a part in all fatal cases, and dominate the symptoms in almost all cases of recov- ery. Even when death is the immediate result of haem- orrhage or inflammation, or when, though life be saved, the mind is lost, they still ride behind. In every fatal case, with fracture or without, where necropsy has been permitted, one at least of these lesions has been found to exist. In every one in which necropsy has been de- nied, as well as in every case of recovery, the interpreta- tion of the symptoms in the light of what has been dis- closed by previous post-mortem examination, has pointed to the same conditions. They do not occur, however, with equal frequency. While in fifty-eight cases there were forty-eight with lacerations, there were but thirty with marked contusions; or, differently estimated, there were twenty-eight cases of laceration without noticeable contusion, and but ten of contusion without laceration. The lacerations may be single or multiple ; they may be confined to the cortex, or extend a variable distance into the subcortical structure; they may originate subcorti- cally and completely disintegrate the interior of a lobe without encroaching upon the cortex, or they may reach the pia; they may lacerate the pia and rupture the arach- noid, with or without diffusion of haemorrhage, or the membranes may remain intact. In a large proportion of cases the laceration will be with well-marked diffusion of haemorrhage. Topographically, there is no lobe or STUDY OF INJURIES OF THE HEAD. 325 convolution which may not be wounded. It will be seen from the necropsies recorded, that the base of the brain, especially upon the frontal and tempero-sphenoidal lobes, suffers most seriously and most frequently, and that the interior of the frontal lobes is oftenest the site of extensive destruction. Several cases will be noted in which the haemorrhage from a lacerated frontal lobe has broken through the lateral ventricles into the posterior regions of the brain. I present a specimen of small laceration in almost the exact centre of the cerebellum (Case XXXIV.). I have no record of laceration of the optic thalami, fornix, velum interpositum, or corpus cal- losum, though such injuries have been described. I also present a specimen of laceration of the pons (Case XXIV.). Instances of the laceration of the corpora striata and gyrus fornicatus are included in the series (Cases XX., XXIX., XXX., XXXV.). The general ap- pearances of these lacerations have been noted by previous writers under the name of contusions, and they require but cursory mention. As they present themselves in the cortex, they are simply lacerated wounds contain- ing more or less coagulum with underlying shreds and granular detritus of brain tissue. After the removal of the coagulum the bottom of the wound is usually pulta- Ceous, and stained with blood or of a grayish color. Some- times the peripheral brain tissue is softened and dotted With miliary extravasations, and sometimes it is of nor- mal consistence and appearance. It is rarely the case that there is not some resulting haemorrhage which in- filtrates the pia, perhaps trivial in amount, perhaps suf- ficient to thickly cover the base or vertex, and the lat- eral aspects of the brain. The wound may be circular, oval, or irregular in outline, not larger than a pea, or Covering the whole extent of the inferior surface of the temporo-sphenoidal lobe. In case of subcortical lacera- tion, the lesion may be a simple extravasation of blood *to the deeper brain tissue, as small as in the specimens from the pons and central cerebellum which I have just 326 NEW YORK STATE MEDICAL ASSOCIATION. exhibited, and either as harmless as it is trivial in extent, or of deadly import. In another instance, as in more than one of the necrologies which I have just recorded, the whole internal structure of both frontal lobes may be disintegrated and destroyed ; and when the clot and mangled brain have been turned out, nothing but the cortical shell remains. . The subsequent changes which these wounds undergo are not numerous. If of considerable size, death ensues in the majority of cases before sufficient time has elapsed to permit any change of importance. The end to be hoped for, as in any wound with loss of tissue, is cicatrisation. In an experience in the dead-house lasting over many years, it has not been my fortune to meet with an instance of such reparative process, yet I have seen many cases of recovery where I am positive lacera- tion had existed. There is a remarkable illustrative specimen in the Museum of St. George’s Hospital, quoted by Mr. Hewitt, in which two large lacerations of the cerebrum, occurring without fracture, had cicatrised after many years. The cerebral surface was excavated, and the pia and arachnoid were carried over the depres- sion, leaving a cavity filled with loose areolar tissue and serum. The man’s intellect had been clear, and he had suffered no cerebral symptoms. If the patient survives, the process of reparation is evidently slow. In certain cases in which old lacerations were discovered after death from more recent injury, there was no contraction of the wounds and no in- flammatory changes of importance had begun. The edges of the wounds were slightly rounded, and the coagula which they contained were softened, and their color had become rusty or yellow. In necropsic cases of recent laceration, an interval of from a few moments to one day, or several, has probably elapsed. The appearances are practically the same whatever the interval may have been. There is no tendency to meningeal or visceral inflammation in any STUDY OF INJURIES OF THE FIEAD. 327 cases which I have observed, with the exception of the occasional formation of abscess from subcortical laceration. As in the case of general contusion, with profuse oedema and death after fifteen days, no inflam- matory changes have been discovered, even upon careful microscopical examination. In an exceptional case (Case VII.), the temporo-sphenoidal lobe had been seriously lacerated, and after the lapse of six months was the seat of interstitial inflammation and atrophy. CONTUSION. Contusion may be regarded as occurring in three forms—general and limited, affecting the brain ; and meningeal, involving the membranes. The limited form may be either cortical or subcortical. Any two or all three of these may coexist in the same case. Limited contusion of the brain differs from laceration as a contusion elsewhere differs from a wound. There is no palpable solution of continuity in the brain fibres, and Consequently the haemorrhagic extravasation can only be minute in quantity and of punctate or miliary form. In reparation, only absorption, not cicatrisation, is required, and recovery should occur in the major, and not, as in laceration, in the minor proportion of cases. It is there- fore less frequently met with in post-mortem observa- tions. As in cortical or subcortical laceration, either form of limited contusion occasionally results in abscess. In the subcortical forms it may be difficult or impossible to determine which one of the two is the responsible lesion. I have very carefully described such an abscess In a case reported in the Wew York Medical Journal, March 19, 1890, and included in the present series. This abscess, which complicated fracture at the base, and two others complicating compound fracture of the ver- tex, comprise the small proportion of cases which rep- "esents the danger of this form of inflammation. In the case first mentioned, though fracture at the base 328 NETW YORK STATE MEDICAL ASSOCIATION. existed and made it technically one of that class, there was also compound fracture of the vertex in connection with which the abscess was formed. So we may properly consider all the abscesses as complicating the latter form of fracture. In all three cases the dura was carefully examined at the time of accident and found to be unin- jured, and after an interval of more than two weeks without the occurrence of meningeal inflammation, the abscess was developed. In each the external wound had been healthy and had nearly closed. These data seem to prove that suppurative inflammation of the brain sub- stance is the result of primary injury of the brain itself, and not secondary to meningeal inflammation extended from the point of fracture. The time for cortical and meningeal suppurations passed with the coming of aseptic methods, and at the same time hernia cerebri practically disappeared from the field of surgery. These cases, however, show that compound fractures still sustain a relation to deep abscess. It is not dependent upon the extent of the attendant laceration or contusion, for that is likely to be as great under other circumstances. It is more probably due to exposure, for, though uninjured, the dura and cortex may not be impervious to atmos- pheric influences. The explanation of this subcortical suppuration is, at all events, neither more nor less difficult than that of subcutaneous suppuration upon the surface of the body. The dogmatic assertion that traumatic abscess of the brain never occurs except there has been wound of the scalp or fracture of the skull is erroneous. Though the cases which I record here conform to this proposition, I am cognisant of at least two cases which do not. One was a small parietal abscess which I saw Some years ago; the other an abscess of enormous size in the frontal lobe from a blow received in the ball-field, without the occurrence of superficial injury of any sort beyond moderate contusion. The latter specimen is still in the Museum of the Carnegie Laboratory. The important fact in connection with cerebral abscess at the STUDY OF INJURIES OF THE HEA. D. 329 present day is, that it occurs from direct brain lesion independent of injuries of the scalp, skull, or meninges. General confusion of the brain is more frequent than the limited form, but much less frequent than laceration. I am accustomed to recognise it in three post-mortem conditions: General hyperaemia, with or without oedema, punctate or miliary haemorrhages, and throm- bosis of the minute cerebral vessels. They occur separ- ately or together. Examples of each are afforded by the necropsies I have described, and the appearances they present are sufficiently indicated in the enumeration of post-mortem conditions which I have made. I will only refer to two very recent cases (Cases XXXIII. and XXXIV.) as well-marked instances of excessive general hyperaemia from general contusion accompanying lacer- ation, and to one other (Case XXIV.) in which death was due to general contusion with oedema. The very mod- erate hyperaemia, which often exists in connection with other lesions, I have not specially considered, though it may be of Serious importance. Meningeal confusion, as a distinct complication, occa- Sions haemorrhage and inflammation. Its relation to general contusion of the brain is not closely defined. The two conditions occur together or separately, and Severity of One, when they are coincident, is not always proportionate to that of the other. I may instance as illustrative of this uncertain relation two cases—the one of oedema to which I but just now referred, in which the brain tissue was sodden and the ventricles distended With serum, while the meningeal vessels were but slightly congested and the subarachnoid Spaces notably dry; the other, my single case of acute arachnitis to Which I shall refer later, in which the whole subcortical tissue was very markedly hyperaemic and the smaller vessels filled with coagula. I do not regard simple *ningeal hyperaemia as other than a factor in the more *Portant lesion of laceration or general contusion, With which it may happen to be associated. 330 NH|W YORK STATE MEDICAL ASSOCIATION. Haemorrhage is of frequent occurrence. The vessels of the pia are ruptured and the blood is effused ordina- rily in a rather thin sheet over one or both hemispheres, but may present itself in patches scattered over any part of the brain. When the haemorrhage is more profuse and the clot thicker, it can probably be traced to its source in a cortical laceration. The coexistence of both forms of cortical haemorrhage is not infrequent. If the fact be fully recognised that cortical haemorrhages of traumatic origin, unconnected with cortical laceration, and without fracture as well as with it, are the result of meningeal contusion, the subject will not require further COmment. - Traumatic arachnitis, so far as these records show, does not result from direct injury transmitted through fracture of the skull, nor from an inflammatory process propagated from a cortical laceration. This complication was once supposed to be the great danger to be feared from injuries of the head, and when death ensued it was always charged with the fatal result. An examination of the fifty-eight post-mortem observations I have made, discloses only seven cases in which it was possibly pres- ent, and only five in which it was positively determined. Two of these occurred in connection with fractures at the base, and the remainder in simple injuries of the brain in which no fracture existed. One of the former was an acute arachnitis; the other six were characterised by a Subarachnoid serous effusion. They all negative the theory of direct violence, or of an extension of a prior inflammatory process. The acute arachnitis (Case XVIII.) was localised in the right and left occipital regions, while the attendant fracture and subcortical lesion were in the parietal region of one side, and separated from it by an interval in which there was no purulent effusion. General contusion was also pres- ent. In the case of subacute arachnitis which compli- cated a fracture at the base (Case IV.), the depressed portion of the fracture which was in the vertex Was STUDY OF INJURIES OF THE HEA. D. 331 confined to the external table, the local lesion was subcortical, and there was evidence of general contusion. In the five other cases, in which there was more or less evidence of Subacute arachnitis, there was no fracture at all; in three there was no laceration, but general contusion or cortical haemorrhage from meningeal contu- sion ; in one of the other two the subarachnoid effusion was localised on the opposite side of the brain from the site of the laceration ; and in the other, and last of the series, the lacerations were old and considerably antedated the immediate cause of death. There can be no doubt that all of these were the result of menin- geal contusion. Paralysis.--Another complication which has been Supposed to have been a direct result of fracture is paralysis from bony compression of the cranial nerves. This condition is represented in a single case. In this there was compression of the optic nerve. There was fracture extending through both anterior fossae, involv- ing the left optic foramen, and pinching the optic nerve at that point (Case LIX.). Loss of sight was immediate, and Ophthalmic examination showed the condition of the nerve and eye to be normal. Subsequent examinations discovered progressive atrophy. The patient recovered, but loss of sight was permanent. In other cases in which loss of function occurred in parts to which cranial nerves are distributed, as elucidated by post-mortem examina- tion, the cause was found to exist in lesion of the Cortical centres or in compression of the nerve by blood effused into its intra-Osseous canal of exit. There is so little displacement in fracture of the base that such instances as the one detailed are probably of great infre- Quency. CONTRE-COUP. I have called attention to the fact that fractures are usually the result of direct violence, expending its force upon the vertex or transmitted in continuity to the base, 332 NEW YORK STATE MEDICAL ASSOCIATION. and that fractures by contre-coup are exceptional. Lac- erations and contusions of the brain, on the contrary, are almost invariably produced, either wholly or in part, in this way. In the minority of cases in which some encephalic lesion exists directly beneath the point at which violence has been inflicted, there has usually been further and more serious damage done to the brain in Some distant part. There has been either laceration or general contusion discovered in each case subjected to post-mortem examination. If the cases of gunshot laceration are excluded, and also those of general con- tusion in which a question might arise as to the kind of violence to which the lesion should be ascribed, there are only five instances in which the violence inflicted was exclusively direct. It is almost safe, therefore, to assume in any given case that if a lesion of the brain exists, it has been produced by contre-coup at a distance from the seat of direct injury. A careful examination of the cases cited shows this distant point to be al- most always upon the opposite side of the brain, and confirms all previous observations that it is likely to be at the base, in the middle or anterior lobe. The reasons which have been adduced to explain the frequent occur- rence of brain injury by contre-coup, and its seat by preference, have no relation to these necropsies and need not engage our consideration. (JONOUSSION AND COMPRESSION. All traumatisms involving brain symptoms were for many years classified as cases of concussion or compres- Sion. The classification was undoubtedly simple and of easy comprehension. If the intracranial space was di- minished by the intrusion of bone, serum, extravasated blood, or pus, it was compression. Otherwise all Symp- toms were referred to a hypothetical vibration of the brain within the skull, a merely functional disorder produced by violence. Twenty years ago Mr. Prescott STUDY OF INJURIES OF THE HEAD, 333 Hewitt described several forms of contusion, in which he included lacerations, and questioned the occurrence of concussion as a distinctively pathological condition without the existence of anatomical change. Previous to this time several observers had noted structural changes in certain fatal cases, but had not regarded them as either necessary or invariable. Some years later Bergmann, in a clinical lecture, admitted the existence of both concussion and compression, with an aetiological difference, and insisted upon their clinical identity. He attributed concussion to a direct injury from a single impulse, modified by the elasticity of the skull, by which the brain suffered a diffuse disturbance of nutri- tion without appreciable lesion. He considered it a suspension of cortical activity, followed by a stimula- tion, and eventually by a depression of the medulla. He recognised it as occurring in three degrees: 1. In- volving paralysis of the cortex only ; 2. Paralysis of the cortex and stimulation of the medulla ; 3. Paralysis of both cortex and medulla, with brief and unobserved medullary stimulation. Cortical paralysis was indicated by unconsciousness; medullary stimulation by slowness of pulse and increase of arterial tension; and medullary paralysis by rapidity of pulse and decreased arterial tension. In compression, he regarded the brain condi- tion as being identically the same, and manifested by the same symptoms, but due to change of cranial ca- pacity and not, as in concussion, to change of cranial form. Finally, he considered diagnosis as only possible by the duration of the symptoms. This clinical lecture was admirably translated by Dr. John C. Schapps, late house surgeon at St. Vincent's Hospital, and appeared in the Annals of Surgery in 1882. The views of Bergmann, of which I have presented a résumé, are of great weight and authority, and probably represent the cumulation of thought and observation up to that time. I do not know that very much of importance has been added Since. I am quite in accord with his opinion that con- 334 NEW YORK STATE MEDICAL ASSOCIATION. cussion and compression should be regarded as One, but would go further, and, having consolidated the two, would abolish them both together, so far as they are terms used to express a pathological condition. The difficulty with all explanations of concussion is that, of necessity, they are largely theoretical. To account con- clusively for unseen pathological changes, or to authori- tatively deny their existence, requires that the syllogism be very carefully constructed. In this instance, in every fatal case where the clinical history has corresponded to that of recovering cases, a carefully conducted necropsy has revealed organic lesion. In all cases that have been cited to prove that no post-mortem lesion exists, not one has been observed with sufficient exactitude to make it of the slightest statistical value. There is nothing in analogy to warrant at the present time the assumption that any fatal disorder terminates without involving structural change. Even disorders of the nervous sys- tem, long considered functional, have with closer inves- tigation fallen more and more into line with Organic diseases. It is tenable ground, therefore, to hold from both negative and positive post-mortem observation, as well as from general analogy, that brain injury produces struc- tural change with the same certainty that it occasions palpable symptoms. If the terms concussion and com- pression be used to indicate a group of symptoms, or a variation of pathological condition, it is objectionable, both on the score of propriety and as being likely to lead to erroneous diagnosis. If they be discarded, the form of injury the patient has suffered in a given case—as lacer- ation, general contusion, or fracture with haemorrhage —is more likely to be accurately determined than if at- tention be directed solely to a symptomatic condition that may not clearly exist. If unconsciousness and vari- ation of pulse be accepted as the sole pathognomonic and invariable conditions of traumatism, there will still remain many cases of uncertain status. Examples may be cited from the foregoing necrologies in which, from the STUDY OF INJURIES OF THE HEAD. 335 earliest moment at which the patient could be reached, there was neither unconsciousness nor a typical variation of pulse. There can be no doubt, however, that uncon- sciousness is one of the earliest and most constant symptoms of serious brain injury. The opinion that consciousness resides in the cortex as a whole, and that unconsciousness is paralytic or inhibitory, is confirmed by the negative results of physiological experiment and by the artificial production of cerebral anaemia. It may properly be regarded, therefore, as symptomatic of brain injury with diffuse effect, but not necessarily of diffuse injury. The primary retardation and subsequent acceleration of the pulse which have been experimentally proved to be attributable to medullary lesion, are not as constant, and are consequently of less symptomatic im- portance. In a majority of cases, at the first moment assistance can be rendered, the pulse is accelerated as it would be in serious injury of other parts of the body. The ambulance service is exceedingly rapid, so that if the retardation of the pulse is so evanescent a symptom, it has no great practical diagnostic value. The temperature, which has not heretofore received attention as an important factor in the genesis of symp- toms or in the diagnosis and prognosis of brain injuries, Seems to me of primary importance. Analysis of the temperatures which have been re- Corded in these histories, confirms the impression which I formed early in my study of these cases—that an eleva- tion of temperature was an early, continuous, and very Constant symptom in all classes of head injury. I have a record of temperatures in 45 cases in which the diag- nosis was confirmed by necropsy, as well as in 10 other fatal cases and in 28 cases of recovery, a total of 83 out of 124 altogether. I think there can be no doubt of the propriety of including the cases of death without ne- Cropsy and the recoveries, since the diagnosis was in each well established. I have a definite recollection that * a Considerable number of other cases in which the 336 NEW YORK STATE MEDICAL ASSOCIATION. temperature was carefully observed and recorded, but in which the charts were unfortunately lost, that the aver- ages were not essentially different. Four cases, which proved to be fatal, were admitted with subnormal temperatures—from 94° to 98°. In two, a subsequent rise in temperature was immediate, con- tinuous, and very considerable; in the other two, death ensued in a few hours without reaction ; in all the pulse indicated medullary paralysis, and the lesions were afterward found to be extensive and severe. In six other cases, the patient was not admitted to a surgical ward till the second day or later after the reception of the injury, so that the first temperature taken could not be considered primary, but in each case it was then notably elevated—from 101° to 104-8°. In one recovering case of fracture of the base with epidural haemorrhage, it was normal, and never exceeded 99°. In the remain- ing seventy-two cases, without exception, the temper- ature on admission was above normal. In the majority it exceeded 100°, and ranged all the way from 98.8° to 106°. It would be difficult to trace a relationship be- tween the character or location of the lesion and the comparative elevation of temperature. The increase was usually progressive, without much recession, and the maximum was reached usually just before death, but sometimes afterward. The highest temperatures at- tained were 109° in one case, 108° in one, 107° + in eight, 106° -- in ten, and 105°,+ in nine ; in other words, in twenty-eight cases it was above 105°. In eleven other cases it ranged from 104°-H to 103°-H. In three cases the post-mortem temperature was 108-8°, 109°, 109.4° respec- tively. Sufficient data have been given to thow that in probably no condition, except insolation, is the temper- ature so uniformly high as in cases of encephalic lesion. Unconsciousness, as an early symptom, sometimes fails without apparent explanation in cases in which brain injury is undoubted. A variation of temperature, there- fore, is the one invariable symptom, and if the patient STUDY OF INJURIES OF THE HEAD. 337 has rallied from immediate shock, it is always an eleva- tion. Perhaps, like the retardation of the pulse, de- pression of temperature may always be the primary change, but, if so, like the primary pulse change, it is too evanescent to be practically diagnostic. In many trivial head injuries elevation of temperature is abso- lutely the only symptom ever recognised. The symptoms should be rated in order of constancy—elevation of temperature, unconsciousness, and acceleration of pulse. Since this elevation of temperature is a constant phe- nomenon, whatever the nature of the lesion or wherever situated, it would seem to be due to an affection of the cortex as a whole, and not to special lesions of localised heat centres. To this extent it might be comparable to experimental results in the attempt to discover cortical centres for Organic functions. To what degree and in what manner the demonstrated heat centres are im- plicated in the general cortical change, is not within the Scope of this paper to discuss, nor within my province or Competency to determine. The primary effect of brain injuries may therefore still be attributed to an affection of the cortex in its totality, in accordance with Bergmann’s view, but manifested by tWO symptoms in place of one—an invariable variation in temperature and a nearly invariable loss of conscious- ness. There is no reason to doubt that the medulla is next involved, and the effect of its stimulation and sub- Sequent paralysis have been too thoroughly demonstrated to admit of question. The diagnostic value of the symp- toms it affords, however, has not been apparent in these histories. I have not quoted the pulse records, because they have not been sufficiently characteristic to justify the DeCeSSary expenditure of time and labor. The post-mortem observations disclose in every in- stance grOSS lesions in one or more regions of the brain or its membranes, which give a material basis for the Symptoms which preceded death, whatever may have been the intervening processes which connected the 22 338 NEW YORK STATE MEDIOAL ASSOOIATION. structural change with its outward manifestations. It is for this reason that I would exclude the terms concus- sion and compression from systems of classification and descriptive histories of cases. SYMPTOMATOLOGY. The symptoms of injuries of the head, excluding those which are casual and without diagnostic significance, are fairly numerous. Fracture at the base has two symp- toms peculiar to itself, and fracture of the vertex has also two; the others are common to both forms of fract- ure and to purely encephalic injuries. Those peculiar to fracture at the base are, serous discharges from the ears or nose, and haemorrhages from the ears, nose, or mouth, and into the orbital, subconjunctival, or cervical subcutaneous tissue. The characteristic symptom of fracture of the vertex, aside from a possible local serous discharge, lies in its perception by sight or touch. The symptoms of encephalic injuries, as a class, whether they occur independently or as complications of fracture, are superficial injuries; peculiarities of temperature, pulse, and respiration; unconsciousness; delirium ; irritabil- ity; paralysis; muscular rigidity ; convulsions; anaes- thesia and hyperaesthesia ; pupillary changes; and, in a late stage, dementia. Other symptoms, as cephalalgia, vomiting, vertigo, incontinence of urine and faeces, are frequent, but of less clinical value. The haemorrhages, serous discharges, and visual or tactile detection of fracture are pathognomonic. The haemorrhages occurred in twenty cases and the Serous discharge in one, and the necropsy in each confirmed the indication the symptom had afforded. In the fourteen cases in which they were absent, the line of fracture in each was found to be such as to preclude the escape Of blood during life through any of the recognised chan- nels. The direct evidence of fractured vertex was pres- ent in five cases, including three of gunshot wound. STUDY OF INJURIES OF THE HEA D. 339 There were simple contusions, large haematomata, or wounds, perceptible in fifty out of the fifty-eight cases. These superficial injuries were of great importance, not only by affording positive proof that violence had been suffered in cases where unconsciousness of the patient and absence of history rendered such confirmation es- sential, but by indicating the point at which it had been inflicted. - Sufficient has been said of variations of pulse and tem- perature and of unconsciousness, and little need be added in regard to peculiarities of respiration. In the majority of cases it was simply rapid or normal, and the chart records have not been transcribed for the same reason that they were omitted in the case of the pulse. It was occasionally slow, in some instances not more than seven or eight in the minute, sometimes irregular or stertorous, Sometimes of the Cheyne-Stokes variety, and in two or three instances dependent in character upon the presence of pulmonary oedema. As in case of the pulse symptoms, I have been struck by the habitual absence of distinctive respiratory indications of medullary implication in Serious cortical disturbances. * Delirium, or some form of mental impairment, is of rather frequent occurrence. It sometimes replaces un- Consciousness as the earliest noticeable symptom, and Sometimes appears as a much later manifestation. It may be violent and simulate alcoholic mania, or it may be mild and coexist with stupor. The most characteris- tic form of mental disorder which I have encountered in Cases of head injury is that of nocturnal delirium, with more or less mental disturbance by day, and in time lapsing into permanent dementia as a termination, or Sequel, of the traumatic lesion. It may follow at once ºpºn recovery of consciousness, or it may succeed active delirium. At night the patient often requires mechani- Çal restraint, while during the day he answers questions intelligently, is coherent in his speech, and may appear entirely rational. His memory, however, is defective, 340 NEW YORK STATE MEDICAL ASSOCIATION. or wanting altogether, in regard to all the circumstances attending his injury. He has delusions and fails to recognise his surroundings. He is prone to drink his urine, and is often apathetic. His mind may finally become clear, his memory of lost events return, and his mental recovery be complete. In other cases his con- dition becomes one of dementia, and some degree of mental impairment is permanent. Such a condition as I have described I presume is not novel to the alienist, but I note it as a special characteristic of injuries of the brain substance, not as a Sequel, but as a symptomatic condition of recent lesion. Another allied symptom is the sensitiveness to external irritations observed in cortical lesions. It seems to be not only a hyperaesthesia of the cutaneous surfaces, but also a marked mental irritability. There is not only exaggerated muscular movement from slight irritations and disturbances, but the patient manifests great vexa- tion and impatience, though apparently unconscious. It is not usually followed by muscular spasm. Convulsions, muscular rigidity, and muscular tremor may also be classed as irritative symptoms. The first and Second occur in a considerable number of cases, a majority of which prove fatal, and upon necropsic ex- amination, disclose haemorrhages and extensive lacera- tions, and possibly general contusion. In the case of atrophy of the temporo-sphenoidal lobe, already de- scribed, convulsions were exceedingly severe; but they followed operation, and a single one occurred fifteen days after the original injury, so that it is by no means certain that there was any aetiological connection between the lesion and the symptom. It is fair to assume that they are always evidence of serious lesion, even when recovery follows. The few instances of mus- cular tremor were in men addicted to drink, but not intoxicated, and who died from the effects of extensive structural changes. Paralysis and anaesthesia, general and local, are reC- STUDY OF INJURIES OF THE HEA. D. 341 ognised indications of traumatic, not less than of idio- pathic, affections of the encephalon. In the present series of cases they have occurred perhaps oftener than indi- cated in the histories, since in so many instances con- sciousness never returned. In this condition, paralysis of the extremities and certain of the local paralyses— facial, ocular, or even glosso-pharyngeal—can be recog- nised ; but many others, as well as sensory disturbances, remain hidden. The multiplicity of lesions, which is the rule rather than the exception, is confusing. In testing cutaneous sensibility the results are sufficiently contra- dictory and unsatisfactory even under more favorable conditions. Yet, despite all these difficulties, in two cases of lesion of the gyrus fornicatus the observations were productive of some result. In three cases of con- jugate deviation, the necropsies afforded more or less satisfaction according to the view taken of the location of the cerebral centre. In a general way, however, while traumatisms may in some instances be of service in the Solution of various unsettled questions in cerebral local- isation, such cases will probably continue to be excep- tional. The fact that defined lacerations are so largely situated at the base of the brain, out of the region in which func- tional areas have been located, still further diminishes the chances that traumatism will aid much in perfecting Cerebral topography. It is none the less important, in all cases of profound unconsciousness, to examine criti- cally for such forms of paralysis as are undoubtedly recognisable, as well as for those, the discovery of which is likely to be more problematical. Pupillary changes are valuable positive evidence of or- ganic injuries, but are less important as negative signs. In a minority of fatal, as well as of recovering cases, I have found the pupils to be abnormal—either variable, unsymmetrical, dilated, or contracted. Unilateral dila- tation is probably the most frequent deviation from the *Ormal condition, and is likely to be associated with 9ther and more decisive symptoms. 342 NEW YORK STATE MEDIOAL ASSOOIATION. I shall not stop to consider casual or remote general symptoms, though, in connection with others more characteristic, they sometimes acquire a value which is not intrinsic. Vomiting, and incontinence of urine and faeces are among the most constant symptoms encoun- tered in head injuries; but the one is not less frequent in peritonitis and pregnancy, and the other is quite as common in a great variety of functional and organic dis- orders of the brain which have no relation to traumatism. There can be no doubt, however, of the value of such indications when they occur under circumstances which render traumatism probable, either by the history or by the concurrence of more directly suggestive symptoms. In the same connection, occipital headache might be mentioned as so general in recovering cases of fracture of the base with epidural haemorrhage, as to assume almost diagnostic importance. I have not specifically noted in the various cases the symptoms which were not manifested, but with the exception of temperatures, when unmentioned, they may be regarded as absent. The results of head injuries have been sufficiently indi- cated as recovery, death, and dementia. DIAGNOSIS. The diagnosis of injuries of the head, as a class, is always of interest, is usually practicable, and under some circumstances is one of the most important in the domain of surgery. Grievous error has entailed equal disgrace upon the surgeon and suffering upon the patient. These lesions are to be distinguished first from all other morbid conditions, especially from those involving loss of consciousness or delirium, and, secondly, they are to be discriminated from each other. It is unnecessary to enumerate or consider all those diseases which may simulate their symptoms. The one of primary and para- mount importance, and which demands most earnest and STUDY OF INJURIES OF THE HEAD. 343 careful attention, is the coma produced by alcohol. Its importance cannot be overestimated, not only because it is the one with which the condition of traumatic coma is most likely to be confounded, but because error in diagnosis inflicts so much unnecessary suffering, addi- tional danger, and possible disgrace upon the patient, while it places the most serious responsibility upon the surgeon. The number of instances in which injuries of the brain have been mistaken for alcoholic coma, and the patient left to die in the cells of a police station, or committed to the alcoholic ward at Bellevue, or even sent from a police court to a term of imprisonment, is inex- cusably great. A large proportion of such cases which came into my service at Bellevue, previous to the past year, were transferred from the alcoholic ward. It is a pleasure to acknowledge that within the year great progress has been made in the acquisition of knowledge among those who render first aid to the injured, even to the extent of realising that an unconscious man with a Scalp wound is not necessarily drunk, and that even a drunken man may be so seriously injured as to require hospital treatment. Unconsciousness and the existence of Superficial injury of the head should, in any case, arrest attention and awaken suspicion of brain lesion. Coma ought not to be ascribed to alcohol, except by the strictest process of exclusion. Symptoms which are most likely to characterise different forms of head in- jury should be sought seriatim. It should be remem- bered, finally, that, even if the patient be intoxicated, this circumstance should strengthen rather than allay Suspicion of traumatism. I believe the temperature affords the means of absolute diagnosis. I have shown, from the histories I have recorded, and upon which this paper is founded, that Variation of temperature in head injuries is invariable, and that in the exceptional instances in which it is de- Pressed, the severity of associated symptoms will take them out of the Category of doubtful cases. In alcoholic 344 JNEW YORK STATE MEDICAL ASSOCIATION. coma, the temperature is subnormal, and I have found this rule to be absolute. The one case which seemed to be exceptional was reported to me as having a temper- ature of 100°. Investigation proved it to be the result of petit 'mal from Opium Smoking in a young prostitute of the Chinese quarter who had not yet become accustomed to her mode of life. I have made some observations to determine the exact temperature in alcoholic coma. I have succeeded in obtaining upward of twenty cases in which coma was more or less profound, and the temper- ature ranged from 96° to 98°, with a usually full and slow or normal pulse, and the depression of temperature was directly proportionate to the depth of the coma. I had expected at the present time to have collected a larger number of cases, but I have found my opportunities un- expectedly limited. Whetherit be the quality of whiskey, or the moral tone of the lower stratum of society which has improved, I know not, but examples are no longer to be had for the asking. I believe, however, the absolutely uniform results in this number of cases makes it more than probable that a larger number in the future will corroborate the conclusion which has been reached. In the diagnosis of apoplexy or non-traumatic cranial haemorrhage, I have found that the observations of Bourneville coincide with those more recently made. They show that in the commencement of the attack the temperature is subnormal, that it then becomes normal, and remains at that point if the patient recovers, but if he dies, it rises to a marked degree. In twenty-three cases taken from an accessible record, of which seven proved fatal, the temperature in two of the latter rose to 102° and 104°; in all the others, fatalities included, the highest temperature was 100°-H. This is in marked Con- trast to traumatic lesions in which the temperature Con- tinues to rise from the depression, if one existed, and remains elevated while the result remains in abeyance. A case which suggests the occasional difficulty in the diagnosis of idiopathic from traumatic lesion is that STUDY OF INJURIES OF THE HEAD. 345 (Case CVIII.) of the man previously quoted, who was seized with an apoplectic effusion into his lateral ven- tricles and one occipital lobe, and fell from his cab, causing a cerebellar laceration. There is still another in this series very like it, in which a man after an apoplec- tic seizure fell backward, and, like the first, lacerated his cerebellum. In both cases the previous history was known and it was possible to diagnosticate both lesions. It is unnecessary to refer to uraemic coma, Opium narcosis, hysteria, etc., as the diagnostic problems they present are elementary. The active delirium which may occur in the period im- mediately succeeding the reception of a brain injury, is sometimes very difficult to distinguish from that which results from alcoholic excess. The difficulty may be further increased by the fact that the subject is of known intemperate habits, and very likely intoxicated when first brought under observation. In those cases in which delirium is the first symptom noted, and probably re- places unconsciousness (as in Case I.), the condition be- Comes very deceptive. In this instance we are not aided by the temperature, which is almost always elevated in alcoholic delirium, and the elevation may be, and often is very great. I have within a few days seen a case in Which, with quite extensive superficial injury of the head, there was alcoholism to the verge of delirium, a high temperature, a previous history of epilepsy, and present epileptiform convulsions followed by facial paralysis. The diagnosis, which excluded brain injury and Which proved to be correct, was made from observa- tion of the course of the temperature for the first few hours. I am aware of no Single diagnostic sign Upon Which dependence can be placed, and yet I have *Ver seen a case in which it was not possible to make the distinction between the two forms of mental disturb- *nce. There are few head injuries in which there are *ot at least one or two characteristic symptoms which *n be detected if sufficient care be exercised in the 346 NEW YORK STATE MEDICAL ASSOCIATION. examination of the case. It seems to me that there are differences even in the character of the delirium which may be recognised though not easily formulated. The diagnosis from each other of the several injuries which may be inflicted upon the cranium and its con- tents, is fraught with difficulties. The lesions are likely to be multiple and the symptoms to be equally referable to either one of their number; the symptoms of circum- scribed lesion are often lost in those from a diffuse character, and similar results constantly ensue from totally different causes. A more exhaustive study is therefore requisite of the diagnostic value of individual symptoms in their relation to each other, and to estab- lished structural changes, than I have yet been able to undertake. There are, however, well-established facts, as well as strong diagnostic probabilities, which are likely to multiply and to make diagnosis possible in an increasing number of cases. Thus, it is well known that certain haemorrhages positively indicate a definite fracture at the base. A trivial injury of the vertex, and One or two general symptoms may suggest its whole extent and complications. Again, paralysis of an extremity in a recent head injury will positively determine some lesion of a definite portion of the parietal cortex on the opposite side. In the absence of depressed fracture, and with the knowledge that occurrence of laceration or limited contusion at this point is unusual, the ascription of the paralysis to haemorrhage becomes justifiable. These conclusions are legitimate and founded upon positive knowledge and logical inference combined. There can be no doubt, I think, that greater diagnostic significance will attach to individual symptoms in the light of further pathological observation. As an ex- ample, the present series of necrologies seems to show that the peculiar mental conditions I have described are usually preceded by lesion of the brain tissue, and if it be of the membranes, that it is meningeal contusion with inflammation. I have insisted upon the importance of STUDY OF INJURIES OF THE HEA. D. 34? temperature in the recognition of head injuries as a class. I am not at present prepared to raise the question of its diagnostic relation to individual lesions. PROGNOSIS. The prognosis may be first considered from the numer- ical results. The total number of cases is one hundred and twenty-four, of which forty-nine recovered, or nearly forty per cent. The fractures at the base number seventy, of which twenty-one recovered, or exactly thirty per Cent. The popular belief, and possibly the general profes- Sional impression, is that this fracture is a peculiarly fatal accident. I have already expressed the opinion that fracture at the base is devoid of danger except for its complications, but it is so often attended with grave lesions of the brain and meninges that it is not strange that by a species of metonymy it should come to stand for the traumatism as a whole. - It is difficult to estimate the comparative danger of the Several lesions, from the fact that they are so generally multiple, and altogether conspire to bring about the fatal result. It is also true that the severity rather than the form of lesion is to be made the basis of prognosis. It may be, therefore, of no great practical importance to attempt to infer from the necropsies the relative respon- sibility of individual lesions in causing death in each instance. So far as I may judge from comparisons of Symptomatology with post-mortem appearances, when Opportunity has been afforded, I believe death has di- rectly resulted in fully fifty per cent. from laceration and attendant haemorrhage. In the remainder it might be chargeable to epidural haemorrhage, contusion, ab- *SS, or arachnitis, though doubtless in every case some other lesion was contributory. The prognosis made from initial symptoms must depend "Pon their general severity and upon the extent to which 348 NETW YORK STATE MEDICAL ASSOCIATION. the vital powers are implicated. It sometimes happens that the patient survives when the obvious extent of the lesion has made recovery seem practically hopeless. A fracture through both middle fossae, and one, probably both, anterior fossae, might well put an end to hope, and yet such a case (Case LXIX.) did recover. I find that none of my patients have lived in whom the temperature has risen to 105°, but in more than one that degree was approximated. I am not at all certain it might not exceed 105° consistently with recovery. A very high tem- perature, or disturbance of respiration at an early period, or muscular rigidity, is always calculated to excite the gravest apprehension. The late prognosis presents no difficulties, but it ceases to be of professional interest. TREATMENT. I propose to confine whatever I may have to say in regard to treatment, to questions of operation. I omit all reference to medication, as it involves matters of detail for which time is wanting. I premise only a brief men- tion of what may be properly designated adjuvants in general treatment. The necessity of shaving the head, which is conceded in cases with symptoms of marked severity, is equally existent in every case in which there seems to be a possibility of intracranial injury. It per- mits the discovery of diagnostic contusions which are SO Often disclosed only upon post-mortem examination. It relieves the brain, in some cases at least, of a superin- cumbent and thermogenetic weight, which is positively contraindicated and is a factor of appreciable influence. It facilitates the use of the ice cap, which in cases of high temperature and delirium is an appliance of the highest therapeutic value. I have found it so effective that I desire to emphasise its importance. I have sometimes been compelled to maintain its use for a length of time, as whenever it was discontinued the temperature again increased and delirium returned. The resort to a simple STUDY OF INJURIES OF THE HEAD. 349. form of mechanical restraint is often requisite for the mere purpose of retaining the patient in bed. It inci- dentally becomes at the same time a means of quieting nervous excitement and of husbanding physical strength. Trephining may be regarded with less apprehension by the timid since the advent of aseptic methods. Its pro- priety may now be decided simply in view of its probable advantage, or its more probable futility. It may be counted quite as safe as the use of the exploring needle in suspected abscess, and safer than explorative laparot- omy. I should not deem it necessary to insist upon this point were it not that I am so often surprised by denials of what I had taken to be conceded facts. If, as I am in- formed, the temperature rises to a high degree after craniectomy or trephining in children, it is so foreign to my experience in traumatism that I am constrained to attribute it to other causes than to simple perforation of the cranium. I have often found it, on the contrary, to be followed by a depression of temperature when no result had been attained beyond the mere removal of the button of bone. The incision of the dura, or the further exploration of the brain, might be differently regarded, for while trephining, done with due regard to time and method, could hardly inure to the serious disadvantage of the patient, uncalled-for and injudicious interference With the intracranial contents might be positively harm- ful. This possibility is not a contra-indication to going further after trephining, if its propriety becomes evident. In such cases I have always found the temperature to rise as it does in injuries of the brain generally. In the small abscess which I incised through the angular gyrus, it rose, in the sixteen hours which preceded death, from 102.2° to 108°. In the very large abscess in the frontal lobe, upon which I operated only last month, the temperature rose from 99.2° in twenty-four hours to 102.2°, and recovery is even now complete. I should ex- pect an elevation of temperature in any case, but I should not expect any serious results from incision of the dura 350 MEW YORK STATE MEDIOAL ASSOCIATION. or brain per se. So far as subsequent danger or in- convenience from hernia cerebri is concerned, I may repeat a statement previously made, that in the Surgery of to-day it has ceased to be an intimidation to the surgeon. I am quite of the same mind with those surgeons who believe that this operation should be done in every de- pressed fracture where elevation and thorough explora- tion cannot be otherwise accomplished. I believe with them that the absence of general symptoms does not relieve the surgeon from the responsibility of operation. This view was held by my former preceptors, the late Dr. James R. Wood and Dr. J. W. S. Gouley, at a time when to hold such opinion was almost an opprobrium. It commended itself to my judgment then as it does now. It is doubtful if such an operation has been known to do harm when it has failed to do good. It is certain that harm has come in more than one instance when, because of the absence of general symptoms, it has been neglected. It is impossible to tell in a depression of the external table of moderate or perhaps insignificant extent, what more extensive comminution of the internal table may not exist. It is this possibility of even the smallest bony spicula penetrating the brain and causing serious nervous disturbance in the indefinite future, that demands thorough examination of every cranial fracture. It should be held obligatory on precisely the same grounds as the examination and cleansing of a wound in the external soft parts. The observance of such precau- tion is free from danger; its neglect may lead to either present or future serious complications. If the depressed fracture is simple orits existence is in doubt, there should be no hesitancy in making a suffi- ciently free incision to determine the exact cranial Con- dition. It is of very common occurrence that a large haematoma exists in connection with diagnostic Symp- toms of intracranial injury, and that there is no other means than this of acquiring knowledge which may be STUDY OF INJURIES OF THE HEAD. 351 of vital importance. If the result is nugatory, the inci- sion, made under aseptic conditions, will be closed by primary union. It is certainly better to have made many fruitless incisions than to have allowed a single life to be jeopardised by an undiscovered fracture. In case the fracture proves to be a simple fissure, a different rule of conduct will obtain. The probabilities will be against the existence of depression of the inner table, and after the fissure has been traced, with or with- out incision, as far as practicable, or till it has become narrowed to a line, the wound should be closed. If, however, the general symptoms should indicate com- plication, further exploration may become proper and necessary. The indications for trephining are wanting at the present time in the great majority of cases which involve intracranial lesion. If the existence of epidural haemor- rhage is evident, and its location is accessible, the pro- priety of operation is unquestioned. If the existence of circumscribed lesion of the brain can be inferred from local paralyses, anaesthesia, or muscular rigidity, or from the initial symptom of convulsion, I think the pro- priety of operation may be assumed. In the greater number of cases, those in which only symptoms of diffuse lesion can be recognised, the use of the trephine is en- tirely empirical and without justification, unless under- taken for special reason. If, in time, lacerations at the base come to be diagnosticated with reasonable certainty, it may then be proper to inquire whether their exposure by the trephine or otherwise, disinfection, and drainage Would be practicable and advantageous. The accidental result of trephining, in at least two or three cases, suggests its employment on purely medico- legal grounds. I will instance the case (Case CVIII.), already quoted as an example of mixed idiopathic and traumatic lesions, of a man who fell from his cab after * apoplectic effusion and secondarily lacerated his cere- bellum. He was paralysed, anaesthetic, and absolutely 352 WEW YORK STATE MEDICAL ASSOCIATION, unconscious. He was trephined, and a large amount of serous fluid drained away from the surface of the brain. His temperature fell in six hours from 103.4° to 98-69. He became conscious, could articulate, spoke rationally and intelligently, and gave his name and address. At the end of fourteen hours his temperature again rose, and he died. The possibilities of such a case are not less practical than dramatic. The instances I have encoun- tered of such transient returns to consciousness have been sufficiently prosaic and unimportant. The very next, perhaps, might disclose a criminal and avenge the crime. In any one of the many homicidal assaults in which the victim is found unconscious and the assailant has escaped unknown, I believe it to be legitimate to trephine for this direct purpose. Even temporary resto- ration of the mental faculties might suffice the ends of justice. The prospect of success is certainly not alto- gether chimerical, for I have cited a case in which just such a hypothetical result was absolutely attained. The general principles of operative interference in cra- nial fractures and encephalic injury may be recapitulated and formulated as follows: Incision of the scalp, tre- phining, incision of the dura mater, and perforation of the brain, severally or together, should be resorted to without fear or hesitation when indicated. Incision of the scalp and trephining are devoid of danger and are always justifiable for exploration, which in itself consti- tutes an indication. Incision of the dura mater, and incision or perforation of the brain are more serious procedures, and should be made only when positively indicated by the general symptomatology. I have sketched as rapidly and systematically as pos- sible in this paper the conclusions to be derived from the series of histories and necrologies by which it is pre- ceded. So far as they are confirmatory of previous ob- servations, they will have the value which attaches to in- dependent study. If in any particular they differ from accepted teaching, the inclusion of the historical data CORRIGENDA At page 284, Case XXII., for “Six multiple " read “Multiple fissures of the base (six in number).” At page 290, third line from top, for “cortial" read “cortical.” At page 298, Case LXVI., and wherever else in the paper the words occur, for “trephined ” read “trepanned ” and for “trephining ” read “trepanation.” At page 304, fourth and fifth lines from the top, instead of “next four days’ read “in the four days ensuing.” At page 313 Case CXXII., for ‘‘ thus ” read “as.” At page 321, eighth line from the top, for “facial,” read “fatal.” At page 336, eleventh line from the bottom, instead of “ in Other words " read “or.” At page 338, eleventh line from the bottom, for “less" read “lesser.” At page 346, ninth line from the top, after “from " add “one Of.” At page 349, thirteenth line from the bottom, for “positively harmful" read “ of positive disservice.” STUDY OF INJURIES OF THE HEAD, 353 will make it easy either to verify their truth or to refute their error. I beg to acknowledge my indebtedness to the courtesy of my colleagues, Dr. J. W. S. Gouley and Dr. F. S. Dennis, and also to the successive house surgeons at Bellevue and St. Vincent's Hospitals, for their intelli- gent co-operation in the work of observation. 28 THE AETIOLOGY OF GASTRIC ULCER. By CHARLEs G. STOCKTON, M.D., of Erie County. November 17, 1892. The mucous membrane and the deeper structure of the stomach may, from a variety of processes, suffer loss of Substance, and properly enough these may be called ulceration. Thus, from traumatism, corrosives, scalding fluids, from tuberculosis, syphilis, scurvy, or from serious blood changes, from extensive burns, from continued pressure and other causes disturbing nutrition of the part, ulceration may take place. However, for an ulcer, Occurring most often in young women; which is usually round, having about it healthy mucous membrane; its margin being abrupt and clean cut, so that in old cases it has a distinct punched-out appearance (as Rokitansky aptly describes it); generally found alone, but occa- sionally having one or two companions; located, as a rule, on the posterior wall near the pylorus, and often near the lesser curvature; almost invariably associated with an excessive secretion of hydrochloric acid, and not infrequently with anaemia; which is called the simple, the solitary, the round, the perforating, the peptic ulcer, and the ulcer of Cruveilhier, there has been suggested no cause which is satisfactory, or which answers allim- portant requirements. It is not to be supposed that one can draw an uninter- rupted and perfectly visible line of separation between true round ulcer and all other forms of gastric ulceration. It is probable that in many instances the processes are so intermingled and confused that even the fullest knowledge of the facts would leave differentiation in- complete. Still, this fact must not be lost sight of, that THE AETIOLOGY OF GASTRIO ULOER. 355 in the classical “round ulcer” no theory of aetiology so far suggested has proved to be altogether satisfactory. But before discussing this part of the subject, your attention is invited to what we know of the causes of gastric ulcer in general. It is widely believed that the bacilli of tuberculosis, passing through the stomach, may invade the intestinal mucous membrane, and yet, this organism, while not destroyed by the gastric secretion, has not been shown to be a cause of local trouble in the stomach. Notwith- standing this, there are now reported numerous authen- ticated instances of tubercular disease of the stomach," and occasionally extensive ulceration of the mucosa is See Iſl. Syphilis, according to histological examinations made by Guozot,” has been shown to be the cause of ulcer, and Heller” thinks that syphilis plays an important rôle in Congenital ulcer, of which a number of cases have been reported. The disintegration of neoplastic tissue can scarcely be considered as ulceration of the stomach, although it is Well known that cancer often finds its seat in the place of a preceding ulcer. Albertoni," however, reports an ulcer complicated with adenoma of the stomach, and believes that the ulcer resulted from a previous growth of this nature. Turner" describes a circumscribed super- * Musser. Tuberculosis of Stomach. Philadelphia Hospital Reports, 1890, I., 117–124. Hebb. Tubercular Ulcer of Stomach. Westminster Hospital Heports, London, 1888, III., 155–158. Coats. Tuberculosis of Stomach. Glasgow Med. Jour., 1886, 53–61. Choosuek. Ueber Tuberculose des Magens. Wien. Med. Bl., 1882, W., 197 and 233. Kºhl Tuberculose Magen. Geschwilre. Kiel, 1889. Guozot. Contribution à l'étude des maladies syphilitique de l'esto- mac. Bordeaux, 1886. 8 Heller, Quoted by Steinman. Einige Fälle von Magengeschwilre und Jugendlichen Alter. Kiel, 1890. Albertoni. Jour. de Med. de Chir. et de Pharm. Bruxelles, 12, 20, 1890. Turner. Trans. Path. Soc., London, 1884–5, XXXVI., 191. 356 ME}}W YORK STATE MEDICAL ASSOCIATION. ficial slough of the gastric mucous membrane of a man suffering from pyaemia following a fracture of the tibia, and similar cases resulting from septic emboli are reported at long intervals. I have seen erosions of the gastric mucosa resulting from extravasations of the blood into its substance, in cases of purpura and scurvy, and, according to Wales," such lesions, and even distinct ulceration, are rarely absent in the latter affection. Quioroza” reports cases of gastric ulcer resulting from dysentery, puerperal septicaemia, and typhoid fever, and the author believes that the affection is the direct result of numerous diseases of the body. An interesting and ingenious explanation of the affec- tion is that given by Wiktorowsky,” who maintains that from chronic catarrh, the establishment of the chronic interstitial process, up to perforating ulcer of the stomach is but a continuous chain; but proof of this theory is wanting. Nevertheless, Peter* and others hold that round ulcer is the result of a preceding gastritis, and the increased local temperature is mentioned as evidence in that direction. It will be remembered that Cruveilhier” held to the inflammatory origin of the disease. There has been a general acceptance of the views expressed long since by Virchow, that the ulceration follows haem- orrhagic erosions resulting from disturbances of the cir- culation; that “the interruptions of the circulation are for the most part due to morbid conditions of the gastric vessels, and particularly to a haemorrhagic necrosis of the mucous membrane.” This hypothesis at once opens a wide avenue for causative factors, and if it were not for * International Surgery, Wol. I., p. 292. * Études sur l'ulcere gastro-duodenal d'origine infectieuse. Paris, 1888. - * Verhältniss der entzündlichen Processe zu den Ulcerosen im Magen Virchow's Arch. f. path. anat. Berlin, 1883, XCIV, 542. * Le Bul. Medical. Paris, July 12, 1890. * Cruveilhier. Anatomie Pathol. du corps humain, Tome I., livraison X., p. 1. THE AETIOLOGY OF GASTRIC ULCER. 357 certain reasons, hereafter to be mentioned, the attempt to point out a special process in the development of the ulcer described by Cruveilhier would be profitless. It is most natural and sensible to suppose that, given a haemorrhagic necrosis of the mucosa, and the presence of the active gastric juice, the part would become digested, and the typical excavation, so well described by Roki- tansky, would appear. This position is substantiated by clinical observations, post-mortem discoveries and labo- ratory experiments, so that one cannot deny that ulcers are thus established. . In 294 cases, Berthold' found diseases of the circula- tory apparatus in 170, while Steiner reports such changes in 71 cases out of a total of 110, finding particularly endocarditis, end-aortitis, endarteritis. Thrombosis in Various parts was demonstrated 48 times. Litten” saw a perforating ulcer with a thrombus in the splenic artery, and Janeway” describes a like case, where the ulcer was directly due to a fibrinous plug found in the gastro- epiploic artery. Provost and Cotard produced ulcerative changes in various parts of the alimentary canal by intro- ducing tobacco-seeds into the aorta, and other similar experiments are on record ; and, as might have been expected, Letulle” claims to have established the infec- tious origin of the gastric ulcer. By experimental means, haemorrhagic necrosis, and later ulceration have been produced in dogs by several investigators. Ritter" succeeded by poking a dog's Stomach with a cane, and Decker reports like results after feeding hot gruel to dogs. Quincke relates experiments on dogs with gastric fistulae, in which the mucosa Was injured by pinching, excision, or tying off small por- * Statistischer Beitrag zur Kenntniss des Chronischen Magenge- Schwires. Berlin, 1883. * Berlin Klin. Wochenschr., 1880, XVII., 693. * Trans. N. Y. Path. Soc., 1877, II., 1. - * Revue Generale de Clin, et de Pharm., 1888. * Z'tSchr. f. Klin. Med. Berlin, 1887, XII., 592. 358 NETW YORK STATE MEDICAL ASSOCIATION. tions, by thermal irritation, and by caustics. . The ani- mals showed no subsequent distress, and the digestion was not impaired, but the ulcers disappeared after from four to twelve days, although the repair was delayed materially by rendering the dogs anaemic by bleeding. Von Sohlern' thinks that the vegetable diets, by in- creasing the proportion of potash salts in the blood, act against the formation of ulcer, and mentions the infre- Quency of the disease among vegetarian people. Silber- man” repeated these experiments with modifications, and reached the conclusion that ulcer might be caused by arterial anaemia, venous hyperaemia, portal stasis, cir- cumscribed haemorrhages, or reduced alkalinity, and sug- gested that the hyperacidity of the gastric juice might depend upon the lowered alkalinity of the blood. Ulcers following blows on the abdomen in dogs" and men “are reported, and it is well known that the condi- tion is often seen after severe external burns." Localised pressure, as a cause, is mentioned by Ras- mussen," and M. Pettit" has recently described a fatal case which apparently arose from pressure and rubbing exercised by a bony protuberance on the inside of the lower end of the sternum. - Zielinski, of Warsaw, in a recent paper,” considers, as a cause of gastric ulcer, the narrowing of the lumen of the vessels of the stomach from traction made by enter- Optosis. Duodenal ulcer not infrequently follows external scalds and burns,” and occasionally also the stomach is the seat of like lesions;” and severe injuries of various kinds, * Am. Jour. Med. Sciences. Philadelphia, April 1, 1889. * Deutsche Med., Wochenschr. Berlin, 1886, XII., 592. * Ritter Z’tschr, f. Klin. Med. Berlin, 1887, XII., 497. * Wittneben. Ulcus ventriculi traumaticum. Hanover, 1886. * Pitt. Tr. Path. Soc., London, 1886–7, XXXVIII, 140. * Centralb. f. d. med, W’ssensch. Berlin, 1887, XXV., 162. 7 Le Bul. Med., Paris, September 4, 1892. * The Satellite, January, 1892. ° (See Holmes' Surgery.) 19 Pitt. Tr. Path. Soc., London, 1886–7, XXXVIII, 140. THE A.ETIOLOGY OF GASTRIO ULOER. 359 experimentally made upon animals," have been followed by haemorrhagic necrosis in various parts of the body and in the stomach, by ulcers. Precisely how these changes are brought about is not clear, and it is therefore not surprising that, as Niemeyer has suggested, the nervous system may be a possible fac- tor in the process. Indeed, it was with this in mind, that Ebstein made the experiments just alluded to, which were a part of a series of investigations undertaken to show the relation which existed between certain severe injuries and gastric ulcer. Repeating the well-known experiments of Schiff, Ebstein reached somewhat different conclusions; but in the main, both these investigators agree that certain parts of the central nervous system (optic thalam. pedunc. cerebri.) are competent to establish ſulcus ventriculi. Similar results followed a half section of the spinal marrow, and any great and often repeated irritation of the sensory nerves led to quite uniform changes in the gastric mucosa. Talma” was able to pro- duce ulcer by exciting spasm of the muscular coat of the stomach through prolonged stimulation of the left vagus. He suggests that the so commonly present hyperacidity may thus affect the pneumogastric. Apparently this throws light upon the mystery of the relation between external burns and ulcer, and is, at any rate, highly sug- gestive of a possible nervous cause operating in clinical Ca,SéS. Whatever the exciting cause, the lowered alkalinity of the blood, on the one hand, and the excessive acidity of the gastric juice, on the other, are generally acknowl- edged to be active contributing causes. Pavy" teaches that the normal alkalinity of the blood successfully op- poses ulcer, by preventing the auto-digestion of the Stomach. This self-preservation on the part of that * Ebstein. Arch. f. Exper. Path., Vol. II., p. 183. le. Nederlandsch. Tijdschrift. voor Geneeskunde. Amsterdam, No. 24, * Guy's Hospital Report, 1868. 360 MEW YORK STATE MEDICAL ASSOCIATION. Organ has been shown not to be dependent upon this condition, however, since Samuelson made the blood neu- tral, and yet the stomach continued to resist its own secretions. This fact throws discredit upon the theory So long and Securely taught by Cohnheim', and we must now conclude that in such investigations as those of Sil- berman” the resulting ulcers were from some other change in the blood besides the mere lowering of its alkalinity. The views of Ewald” that the blood changes, to be Operative, must be such as lower the resistance of the living cell, are more acceptable. There is apparently a close relation existing between the lowered alkalinity and the hyperacidity. The intimacy of the relation, pointed out by Pavy, has been acknowledged by many. Grime" quotes fifty-three cases Of ulcer, all of which had hyperacidity, and concludes that it is due to the preceding chlorosis, and that with these two conditions present, the slightest injury to the mucous membrane may form the focus of an ulcer. Riegel,” and his students, insist that a great excess of hydrochloric acid is the invariable accompaniment of gastric ulcer, and while this accords with my own ex- perience, and undoubtedly is true of the classical ulcer, there are undoubtedly cases, as shown by Ewald" which are not only without hyperacidity, but even show hypo- acidity. The importance of the acidity in delaying the healing is, as Riegel states," very great, and that it has a marked influence in establishing the lesion is most probable; but the fact remains, that the ulcer may exist and persist without hydrochloric acid, just as it may ap- pear in those who have not an antecedent anaemia. In view of the foregoing facts, necessarily stated in- * Allgemeine Pathologie. * Deutsche Med. Wochenschr. XII., Jahrgang., p. 497. * Diseases of the Stomach. * Lehre vom Ulcers ventriculi rotundum und dessen Bezichungen Zur Chlorose. Amberg, 1890. * Zeitcher. f. Klin. Med. Bd. 12, S. 434. * Diseases of the Stomach, p. 230. 7 Deutsche Med, Wochenschr. Berlin, 1886, XII., 929. THE A.ETIOLOGY OF GASTRIO ULOER. 361 completely and with brevity, it seems justifiable to Sup- pose that while ulcerative processes, dependent upon tuberculosis, syphilis, pyaemia, scurvy, and other Serious dyscrasias, may proceed in the gastric mucosa, and while simple anaemia with lowered alkalinity of the blood as- sists the process, and hyperacidity of the gastric contents greatly favors the change, there must still be some other, as yet unknown cause, which, in a certain group of cases, leads to the local necrosis, besides the accidental changes from thrombi and emboli, such as have been cited above. The reasons for this claim are: 1st, that the affection shows itself particularly in adolescence, or before mid- dle age, when there is the least probability of vascular changes; 2d, that it appears most frequently in women, who are less often subjects of arterial diseases than men ; and 3d, because the ulcer selects for its site, with re- markable frequency, the lesser curvature and posterior wall of the stomach near the pylorus, a portion of the economy which is not often invaded by emboli, and a region of the stomach especially rich in anastomosing vessels. In a large number of cases, Buchmüller' found over 93 per cent. at the posterior wall near the lesser curva- ture, and no certain cases under fifteen years of age. In the Berlin statistics not one case was found under the tenth year, and the greatest number between the twen- tieth and thirtieth years. It is occasionally congenital,” and one altogether exceptional case was found in a man Said to be one hundred and twenty years old.” Greiss' found from three to five times as many scars in women as in men, and over 90 per cent. appeared on the pos- * Pathol. Anatomie des Ulcus ventriculi et duodeni. Würzburg, 1889. * Goodhart. Trans. Path. Soc., London, 1880–81, XXXII., 79. Also Hecker, Monatsschr, f. Geburtskunde, VII. Also Steinman, Einige Fälle von Magengeschwilr im Jugendlichen Alter. Kiel, 1890. * Eppinger, quoted by Welch, Pepper's System, Vol. II., p. 489. * Greiss. Statistik, des runden Magengeschwilrs. Kiel, 1891. 362 JWH}W YORK STATE MEDICAL ASSOOIATION. terior wall near the lesser curvature; and although many of these appeared in middle, and a few in advanced life, the beginning of the trouble was doubtless in earlier life, as Leube has pointed out." Statistics abound in similar statements, as may be learned by consulting Welch’s splendid monograph in Pepper’s System of Medicine. From the foregoing facts, namely—the propensity shown by the affection to select a certain site in females, and to appear in early life—it has naturally led to the Suggestion that this form of ulcer may take its origin in Some unknown but definite neuropathic change, trophic, VaSO-motor, or both. It has seemed to me remarkable that this view has not gained more adherents, since by no other evident hypothesis can these points in its natural history be explained. In reflection on the matter, it has occurred to me that Somewhat analogous processes are to be witnessed in other parts of the body, and that by using these as illus- trations, some insight into the pathology of round ulcer may be gained. For instance, the well-known proclivity Of herpetic eruptions to attack particular points, under especial conditions, is brought forward; and attention is called to this common disease, which, depending upon nerve abnormality, is found not only upon the skin, but upon the mucous membrane of various parts, including the mouth and throat, with a view to asking whether it might not select for its appearance the pyloric end of the stomach, and thus lead to ulcer. Again, there is something most suggestive in that ex- traordinary disease known as idiopathic haematoma auris, which is seen not infrequently in the insane : which invariably appears in the concha, rapidly reaches maturity, and disappears only after destruction of tissue and marked cicatricial deformity. It is interesting to note that the affection has been seen occasionally in those * Ziemssen’s Cyclop., Wol. VIII., p. 203. THE ALETIOLOGY OF GASTRIO ULOER. 363 having no mental disease, or other known disability." In a recent paper on this subject, Dr. H. G. Matzingar re- fers to the complex nerve Supply of the ear, with especial reference to the sympathetics, and concludes that othe- matoma is a neuropathic affection, seen generally, but not invariably, in those suffering from central nerve dis- ease, in which the sympathetic system is seriously in- volved. Why might not some similar process have for its local expression the posterior wall or lesser curvature of the stomach near the pylorus, than which no part of the economy has a more complicated and involved in- nervation ? One is led also to think of the striking manifestations in that curious affection, Raynaud's disease, with its predilection for the fingers and toes; with its advancing steps of Syncope, asphyxia, and necrosis of the parts. It is not impossible that asphyxia of certain spots of the gastric mucosa may occur from analogous causes, what- ever they may be, and the tissue thus put to a disadvan- tage, Would be well calculated to suffer erosion from the active gastric juice. If Morvan’s disease is not found to be a phase of syrin- go-myelia, it also might be advanced as an instance of local necrosis, something like that which may appear in the stomach. - - A few years ago I saw at the clinic of my colleague, Prof. Roswell Park, a case of intense interest—a neurotic girl, who had a series of painful and persistent ulcers along the forearm and leg, following the tracts of certain nerves. The parts bordering the ulcers were uninvolved, and in every way healthy; the ulcers themselves suc- ceeded the appearance of limited gangrenous spots; they Yère deep, with abrupt walls, and were exquisitely sensi- tive. They had for years resisted treatment by very able men. Those on the arm were permanently cured by Dr. Park, by a thorough stretching of the external cuta- * Dr. Sparling. Med. Record, November 9, 1891. 364 NEW YORK STATE MEDICAL ASSOOIATION. neous nerve. There was something about the appear- ance of these ulcers which reminded one of the typi- cal round ulcer of Cruveilhier, and it does not seem to me absurd to suppose for the latter a somewhat similar Origin. Now, in concluding this view of the subject, it appears natural to assume that the stomach, like other parts, may suffer loss of substance from a variety of causes, but as regards simple round ulcer, it must have a more precise and definite aetiology. Unquestionably, the impoverished condition of the blood, leading to lowered resistance of “the living cells,” and the persistent presence of hyperchlorhydria, must of necessity put the tissues to severe strain ; but there is wanted yet another factor. The object of this paper is to suggest that, by the influence of Some process analogous to herpes, or to idiopathic haematoma auris, or to Ray- naud’s disease, or to herpetic gangrene,—some distinct and persevering nerve perturbation, we may best explain the recognised, but unaccounted for feature of the clin- ical history as to location, age, and sex. DISCUSSION. DR. ZERA LUSK, of Wyoming county, said that in the early years of his practice, a gentleman came to him complaining of a burning Sensation in the epigastrium, and of indigestion. A diagnosis was made of gastric ulcer. About two years later he was accidentally struck in the stomach by the handle of a plow, and from the violent symptoms then present, a diagnosis was made of rupture of the stomach. The man died, and owing to certain domestic troubles it was deemed best to have an inquest, and a coroner's jury was impaneled. An autopsy was made, and it was found that the contents of the stomach had escaped into the abdominal cavity, and examination of the stomach showed two round ulcers about one inch apart—one nearly through the walls, probably as a result of the blow from the plow, and the other a complete rupture, large enough to admit the finger. THE EXAMINATION AND COMMITMENT OF THE PUBLIC INSANE IN NEW YORK CITY. By MATTHEw D. FIELD, M.D., of New York County. November 17, 1892. As it has been suggested that the method of examina- tion and commitment of the public insane in the city of New York would be of interest, I have been induced to write this paper. After the passage of the law of 1874, Chap. 446," the Commissioners of Public Charities and Correction of New York City appointed special examiners in lunacy, * $ 1. No person shall be committed to or confined as a patient in any asylum, public or private, or in any institution, home or retreat for the Care and treatment of the insane, except upon the certificate of two phy- Sicians, under oath, setting forth the insanity of such person. But no per- Son shall be held in confinement in any such asylum for more than five days, unless within that time such certificate be approved by a judge or justice of a court of record of the county or district in which the alleged lunatic resides, and said judge or justice may institute inquiry and take proofs as to any alleged lunacy before approving or disapproving of such Certificate, and said judge or justice may, in his discretion, call a jury in each case to determine the question of lunacy. § 2. It shall not be lawful for any physician to certify to the insanity of any person for the purpose of securing his commitment to an asylum, un, less said physician be of reputable character, a graduate of some incorpo- rated medical college, a permanent resident of the State, and shall have been in the actual practice of his profession for at least three years. And Such qualifications shall be certified to by a judge of any court of record. No certificate of insanity shall be made except after a personal examination of the party alleged to be insane, and according to forms prescribed by the State Commissioner in Lunacy (State Commission in Lunacy), and every such certificate shall bear date of not more than ten days prior to such Commitment. $8. It shall not be lawful for any physician to certify to the insanity of *Y Person for the purpose of committing him to an asylum of which the Said physician is either the Superintendent, proprietor, an officer, or a reg- ular professional attendant therein. 366 NEW YORK STATE MEDIOAL ASSOCIATION. whose duty it should be to examine all cases who should come under the care of the department, and, in proper cases, make certificates of lunacy, and present the same for approval before a judge of a court of record, as required by the law, when the adjudged lunatics were sent with such certificates to the asylums of the department. This method has continued in vogue till the present day, except that formerly the chief examiner held the posi- tion of City Physician, and had charge likewise of the city prison. Such was the condition of affairs when I was appointed examiner in lunacy for the department of Public Char- ities and Correction, in November, 1882, my senior being Dr. William L. Hardy, the prison physician. Within the year, Dr. Hardy was relieved of all duties in the depart- ment save those of examiner in lunacy, and Our func- tions became, and have continued, independent. Upon the death of Dr. Hardy in April, 1886, my present asso- ciate, Dr. Allen Fitch, was appointed. In the earlier days there was no special place for the reception of the alleged lunatic, and he was examined wherever he might be, in prison or hospital. Then all the suspected insane were sent to Bellevue Hospital and placed in “the cells.” These were two wards in the basement of the building, one for males and the other for females. In these wards were received not only the supposed lunatics, but all alcoholics, violently delirious, and refractory patients in the hospital, and frequently criminal patients were sent there too for safe keeping. I remember very well visiting “the cells” when an interne of the hospital, at the time when all classes were received. I was called as a surgeon, to see a wretched woman who had received a fracture of the arm in a drunken brawl, and who had been committed there as an alcoholic. It was at night, and the light was dim, and a little child scarcely more than three years of age was clinging to the skirts of its mother, who was sodden with liquor. As I examined the arm of the drunken mother, EXAMINATION AND COMMITMENT OF INSANE 367 the beautiful, innocent, pleading face looked up to me for mercy for her mother, and I could not but be gentle with her for the child’s sake. I thought if the mother would only look upon the child with but a tenth part of that humanity and sympathy with which the child looked up to me, what a different aspect the case would assume. While this was taking place I could hear on all sides the shrieks of fear from those in the delirium of alcohol, and these cries continually excited the lunatic. Long before this time the Commissioners of Public Charities and Correction had recognised the necessity of separating the insane from the alcoholic, and their per- sistent application had obtained an appropriation for the erection of a separate pavilion for the reception of the supposed insane. . The year 1879 saw the completion of the present recep- tion pavilion for the insane at Bellevue Hospital. This pavilion, erected on the grounds of the hospital, is a one- story brick building, divided by iron doors into two wards, one for males and one for females. Each side has a corridor, lighted and ventilated from above, and con- tains eight rooms for patients, besides an examination room and a kitchen. The former contains record and history books and a medicine and instrument chest ; in the latter not only is the food received from the general kitchen of the hospital, but special diet is prepared, as the resident physician may direct; and here also the Carving is done, and all dangerous knives are kept. One room is set apart as a linen closet, where the bedding and necessary clothing for the patients are kept. There is also a lavatory, bath-room, and closets, separated from the Ward by a passage which is ventilated and lighted by Windows on either side, as well as by windows on either side of the closets. The only criticism which can be made concerning the pavilion is, that it might contain more sleeping-rooms, and patients might be retained longer under observation without overcrowding. The Cells were, and still are, under the care of the house staff, 368 NEW YORK STATE MEDIOAL ASSOOIATION. the medical staff dividing the service in looking after the cells. When the pavilion was first established it was placed under the same care, the house physician having the supervision of the cells also having the care of the insane admitted to the pavilion. The examiners passed on the mental condition, and the propriety of commit- ment or discharge, while the treatment of the patient in the pavilion rested with the house physician, who had no special training in the care of the insane, and who had already sufficient work to care for the patients in his regular service, where his interest and heart really were. The oversight of the alcoholic and insane was an extra and entirely secondary duty of a busy physician. Soon after my appointment in November, 1882, Dr. Henry W. Wildman, who had had several years' experi- ence as assistant physician at the asylum on Ward's Island, was appointed permanent resident physician at I3ellevue Hospital, in charge of the pavilion for the in- S&I16). Dr. Wildman resigned in October, 1887, and was suc- ceeded by Dr. Stuart Douglas, who had been assistant physician at the City Asylum for over six years. Dr. Douglas is still the resident physician. In 1885 the general oversight of the pavilion was placed under the charge of Dr. A. E. MacDonald, the general superintendent of the New York City asylums. You may now ask, whence come the patients? The majority of those received at the pavilion are committed to the care of the Commissioners of Public Charities and Correction by the police justices, for examination as to their sanity. The usual term for such commitment is five days—why five days, nobody seems to know, except that such has been the custom, and that length of time is usually sufficient for the purpose. The police justices commit for examination regarding Sanity, such persons as manifest evidences of insanity, VIZ. . 1st. Those persons who are arrested for petty offenses, EXAMINATION AND COMMITMENT OF INSANE 369 the nature and manner of the occurrence indicating an unbalanced mind ; 2d, those persons who interrupt public meetings, or divine service, or who preach or orate in public places, their conduct appearing to be irrational; 3d, persons making complaint before police justices, at police stations, or other courts, to the District Attorney or other public officials, of wrongs and persecutions, Or of claims which appear to be imaginary ; 4th, where citizens complain of persons who annoy them upon what seem to be irrational pretenses ; 5th, persons who may be found by the police wandering about the streets in an aimless or purposeless manner, or acting in a strange manner, or who are unable to give a rational account of themselves ; 7th, those who have attempted suicide ; and 8th, those persons who are brought before a public magistrate, where the charge or testimony would warrant the suggestion that the individual might be insane and irresponsible. It is not infrequent for police justices to commit per- Sons for examination and to indorse across such commit- ment—“To be returned to court if found not insane.” In fact, police justices endeavor to be just, and to commit no person for lesser crimes, when evidence is produced to indicate insanity and irresponsibility, until the question of Sanity has been passed upon by the city examiners. In cases of grave crime they commit for trial, leaving the Court of higher jurisdiction to determine the question of Sanity and responsibility. The Superintendent of the Poor, acting for the Com- missioners, in cases which are made public charges, and Where evidence is furnished that such person is insane and requires care and treatment as an insane person, gives permits for admission to the pavilion for examina- tion. The examining physician for the department, where admission is sought to some hospital, and where his examination leads him to suspect insanity, gives per- ºits for admission to the pavilion, for special examina- tion regarding the applicant's sanity and fitness for 24 370 NEW YORK STATE MEDICAL ASSOCIATION. admission to the city asylums, or other institutions of the department. A certain number of patients are brought by ambulance from residences, where the statement of friends or conduct of the patient leads the ambulance Surgeon to conclude that the patient is insane. Some are Sent directly from police stations, without a commitment from a police justice. These are usually excited, vio- lent, or so sick that the police feel they are not justified in retaining the individual at the police station for the time required to obtain the formal commitment. A few cases are admitted by the resident physician, where patients are brought by friends with letters from the family physician, or where the patient comes volun- tarily, or consents to temporary restraint. Where the patient is violent, dangerous, or very sick, the resident physician feels justified in admitting to the pavilion without the formality of a commitment by a magistrate ; in other cases, it is his habit to recommend an application to some police justice for formal commitment. Patients are transferred from the regular wards of Bellevue Hospital and from the alcoholic ward, but only after the examination and approval of the resident physi- cian of the pavilion, who indorses the card with his sig- nature before the transfer is made. Patients are received from other hospitals and institutions when brought to Bellevue by ambulance. - I have gone into this subject of admission to show the precautions which are taken to prevent the temporary de- tention of any improper case in the examining pavilion. When cases of insanity develop at other hospitals or institutions in the care of the Department of Public Charities and Correction, by order of the general Super- intendent it is the duty of the resident physician of such institution or hospital to report the same to the exam- iners in lunacy in writing, together with a history of the case, and a statement that in his opinion the patient is in such physical condition as to justify his or her trans- fer to the asylum. The examiners are directed to visit ExAMINATION AND COMMITMENT OF INSANE 371 such patients at the various institutions where they may be, and pass judgment on the question of sanity and the propriety of commitment to some of the city asylums. The examiners prefer to make their visits separately, and to arrive at independent conclusions, though they have subsequently to unite in a dual certificate. Under the present dual certificate we are in the habit of dividing the work, and while one examiner makes out the cer- tificates for the males, the other does so for the females; we alternate each month. The first examiner, after the completion of his exami- nation, makes out, if he considers the patient insane, a certificate, and makes oath to it before a notary public, leaving the certificate in the notary’s charge. The second examiner, if of the same opinion, signs the certificate prepared by the first examiner, with such additions as his examination may lead him to make ; then makes Oath before the same notary, who acknowledges the certificate, and in this form it is presented to the judge for ap- proval. Should the two examiners disagree, as some- times occurs, the case is referred to the resident physi- cian, whose opinion decides the disposition of the case. Discretion is exercised by the examiners, and by the resident physician, in regard to the discharge of patients to the care of friends and relatives. If the friends show a disposition and ability to care for the patients, they are usually discharged to their care, if they sign a contract agreeing to properly provide for them. If the patient be decidedly dangerous to himself and others we usually insist that arrangements be made with some institution for his proper care and treatment. All that is required is a reasonable assurance that both the patient and the Community will be properly guarded. When once the patient is lodged in some institution the examiners consider their responsibility ended. Of Course, improper commitment or discharge would be still ghargeable to them; beyond that, they could hardly be held responsible. The examiners stand between the 372 NETW YORK STATE MEDICAL ASSOCIATION. patient and the community; they must guard the welfare of the patient, consider his right to enjoy liberty and the pursuit of happiness, and at the same time, they must guard and protect the community. - A patient should be committed to an institution for the insane for the following reasons: 1st. As the best means to insure recovery. Wealthy patients may be as well or better treated at home, where the home can be constituted an asylum for a single pa- tient. In most of these cases, the only advantage gained is the avoidance of the name asylum, and the benefits accruing from the order and discipline of such an insti- tution outweigh in very many cases all the advantages of home treatment. In public cases, this mode of treat- ment is usually out of the question. 2d. For the patients’ safety and well-being, they must be protected against themselves and their own acts. They must be guarded from suicide, self-mutilation, and acts which result from a failure to appreciate their sur- roundings—e.g., playing with fire, turning on gas, inter- fering with poisonous or dangerous substances, expos- ing themselves to heat and cold, walking into dangerous places, and incurring the thousand-and-one risks which demented persons are ever apt to do. Very many, being unable to support themselves, suf- fer, when at large, from lack of food, clothing, and shelter, and are constantly being brought to the pavilion in the most wretched condition. These patients are usually fairly well off under supervision, and conduct themselves well in asylums. Many have to be protected from ex- travagance and waste of property, the result of delusion Or lack of appreciation. 3d. For the protection of the community. The public demands protection from acts of violence, and from the dangers arising from the purposeless acts of the insane, which threaten the public as well as themselves. Ladies have a right to walk the streets without being accosted, annoyed or frightened by lunatics, who fancy the ladies EXAMINATION AND COMMITMENT OF INSANE. 373 are in love with them ; and the husband should be per- mitted to enjoy his home without interruption and threats from an insane person who imagines the wife is in love with him, and that the husband has cheated him of his rights. The lunatics who believe themselves kings, queens, presidents, and heirs to thrones and property are always dangerous, as well as those who have de- lusions of persecution. Those who have hallucinations, especially of hearing, are dangerous, for they are influ- enced by their hallucinations. The voices which direct the lunatic may never make him dangerous to the Com- munity, but who can tell what the next communication may be God may tell an Abraham to slay his son, and never stay his hand. Simple Simon has wandered through the streets for a generation, and is being jeered at by the boys, as their fathers did before them ; but to-day he turns, and with club or stone dashes out the brains of Some innocent boy. It is now generally acknowleged to be the duty of the community to care for the insane who have not friends with means or the disposition to do so. Public and newspaper criticism are largely due to igno- rance, and a tendency to jump at conclusions without fully inquiring into the method and care exercised, not Only in the examination and commitment of the insane, but their treatment in public institutions. I believe that the citizens of New York City can take pride in the methods employed in the examination and Commitment of public insane, and the provision for the Care of patients during such examination. The recep- tion pavilion is in every respect a hospital, with a resi- dent physician, and competent and trained attendants. Unnecessary detention at police stations and prisons, and the mingling of the insane with the criminal class, is avoided. All patients transferred from the pavilion to the asylum are accompanied by attendants of their own Sex, Who remain with them until they are turned over to the care of the asylum authorities. Opportunity is af. forded in very many cases to obtain a history of the 374 NEW YORK STATE MED TOAD ASSOCIATION. patient, and to consult with friends and allow them the privilege of providing for the patients in other institu- tions, if they have the means and disposition to do so. The Superintendent of the Poor, Mr. William Blake, visits the pavilion daily, and institutes investigation to ascertain if the patients are proper public charges, and if they be properly charged to New York county. The following table will show the number of patients received during the past four years, and their disposi- tion : - # 4 || ##| || 5 || || } { ; F : gº 2. ; F = p3 Q SEX, É ##3 || 4 || ### à É à || 3: ". . ; ; 35 # . ſº 3 || 3 || || 3: | # 3 | # § - || 35 | P: * Male | 997 || 650 | 87 || 135 | 109 8 * |Female | 854 || 616 || 36 | 104 87 11 Male | 1,075 641 || 139 87 | 198 16 * |Female | "s43 | 625 46 63 93 12 Male | 1,066 || 658 || 71 | 193 135 12 * |Female | "sg0 | 601 || 37 70 103 14 Male | 1,138 || 724 56 187 || 144 16 * | Female | 866 | 671 23 54 100 17 TOTAL. 7,669 5,186 495 893 969 106 Total commitments - sº s gº 74.09 per cent. & & & 4 to city asylums - - 67.62 “ “ 6 & & 4 Other ( & tº- tº 6.47 “ “ { { & © transferred to other institutions, 11.64 “ “ £ g ( & discharged - & - 12.63 ‘‘ ‘‘ ( & & & died - tº * 1.38 ‘‘ ‘‘ The percentage of discharges, when I was first made examiner, was over thirty-three per cent, but owing to the greater care exercised in the admission of improper cases to the pavilion, this percentage has gradually diminished So that although the number of admissions has de- creased but slightly, the number of improper admissions has lessened very much. This is due very largely to the EXAMINATION AND COMMITMENT OF INSANE. 375 oversight of a competent resident physician with in- creased power. In conclusion, I would state that every precaution is exercised to prevent improper admissions to the recep- tion pavilion, and that the examiners try to obtain his- tories from friends of all patients, as to previous condi- tion and conduct, and use this as independent evidence in determining the true mental condition of individuals who are presented to them for examination. We cannot but take pride in the fact that very seldom is a case reg- istered at the asylum as “not insane” (I believe but three times in ten years), and never to my knowledge has a discharged patient committed any outrage against the community in that time. The nearest approach to this was, when a mother was discharged to the care of a daughter, and six weeks later both committed suicide. In One other case, a man was sent to the alms-house, and Some weeks later got into the river and was drowned. Whether this was a suicide, or the act of a demented person, is still a question. A large number of alms- house inmates are mildly demented, and are acknowl- edged to be so. These are the only evidences known to the Writer, of misjudgment in the past ten years. A female reporter was once sent to the asylum, and much newspaper comment thereby aroused, so that the examiners cannot now appear in court without the ques- tion being asked them—“You once pronounced a sane person insane, did you not ?” We are fallible. When We are called upon to examine a criminal where there is known to be a reason for simulating insanity, we are naturally suspicious, and view the case in that light; but Why should we look upon every admission to the pavilion With suspicion and consider every person an impostor The individual person referred to was duly committed by a police justice for examination, and the matron of a Home came and gave a history of irrational conduct on the part of the patient, and alleged the existence of suffi- °lent delusions to induce her to make the charge of 376 NEW YORK STATE MEDICAL ASSOCIATION. . insanity before the committing magistrate. That person's conduct was irrational while in the pavilion, as it was before the examiners; she expressed inability to appre- ciate her surroundings, and would give no account of herself, and acted an inability to do so. There was no more reason to disbelieve her conduct and answers than that of any other patient. From her assumed conduct she could not be cast upon the street, and no name could be obtained of any friend, to whom she could be turned over, or who could give any history of her. She was simply a demented person to be cared for until friends should appear, or until she should recover from her apparent demented condition. The examiners of lunacy in New York City are called upon to pass judgment upon about two thousand cases each year. This number embraces individuals from every land under the sun. I have not unfrequently visited the pavilion and found ten patients on a side, not a single one of whom was able to speak the English language, and for some of these it was impossible to find any inter- preter. I can remember once one of the Commissioners of the department tapped me on the shoulder, and point- ing to a Chinaman, said: “Don’t send him to the asy- lum, for no one will be able to say when he has cleared up.” It must be borne in mind that most patients com- mitted to the pavilion grasp the nature of the place, and are at once on the defensive, and deny their delusions. Even demented patients seem to grasp the situation, and those who speak but little English at once deny their ability to speak any but their native language. We work under such disadvantages, yet we strive to be just, not only to the patient, but to the community. DISCUSSION. THE PRESIDENT asked if the author thought the matron of the Home had intentionally deceived him in the case of Nelly Bly. DR. FIELD replied in the negative, and said she was honest, but was herself deceived. DISCUSSIOW. 377 THE PRESIDENT said he had a practical knowledge of the class with which the author, as examiner in lunacy, had to contend. Some of the in- dividuals committed to the State Hospital for the Insane, in Buffalo, are unable to speak English, and no one can be found, in many cases, who is able to interpret for them. To add to the difficulties of the situation, their actions, even when sane, are often very different from what we are ac- customed to observe in others. For instance, a Polish woman may assume a sitting posture on the floor, cover herself with her dress, and show an utter indifference to the usual proprieties of her sex ; and this may continue for days and months together. Under such circumstances, it is quite difficult to say when these people get better, if they have been insane, and oftentimes it is only by diligently questioning their friends that one is enabled to obtain a history of their true condition. The statis- tics presented by Dr. Field, showing such few errors in their commitments, are worthy of the highest commendation, for they evince a skill in diagno- sis, far superior to ordinary practice in the diagnosis of disease. The methods employed in New York City for the care of the insane are a cause for congratulation, for they evidence a high state of public feeling in regard to the interests of all concerned. DR. FIELD said that the chief object in writing his paper was to advo- cate the establishment of such reception pavilions in other places; for so far as he knew, no other city in the United States had such a pavilion. It is not a difficult matter for any large city to have a pavilion of this kind connected with some hospital, thus taking these poor unfortunates away from the surroundings of station-houses and like places. The reception pavilion is also of material assistance to the examiners, as during the inter- vals of their visits, the conduct of the patients is carefully observed by skilled attendants. THE PRESIDENT remarked that the Commission in Lunacy rarely visited Buffalo without bringing up this question of the erection of a pavilion for the insane, and the question of the erection of such a reception pavilion in every county seat had also received consideration. DR. L. J. BROOKS, of Chenango county, asked what proportion of the diagnoses, made by physicians in the various counties who were not experts, were found to be wrong after the arrival of the patients at the asylum. THE PRESIDENT replied that there were two common sources of error, Viz.: first, certain alcoholic cases, who were seen while under the influence of liquor; and secondly, cases of the morphia habit, in which there seemed to be an actual necessity for commitment and restraint, for their own good, but where, after awhile, they cannot be pronounced absolutely insane. The first error can be avoided in many cases by keeping the patient at home for several days under proper supervision. At the asylum, only one or two each year are generally reported as “not insane,” and most of these occur in criminal cases, frequently after an investigation by the Court ; Sometimes after a report from the jury. In the present reports to 378 NEW YORK STATE MEDICAL ASSOCIATION. the Commission in Lunacy, the asylum authorities are oblige to state the number of cases “not insane,” the number of the victims of the morphia habit, and the number of inebriates. The two cases reported last year as, “not insane,” had been sent from the jail after a judicial decision as to their insanity. The ordinary physician rarely makes a blunder in certi- fying to cases of lunacy, and the speaker said his sole reason for referring in his address to the diagnoses made by the general practitioner, was to raise, if possible, the standard still higher, and to secure a more intelligent. preparation of papers of commitment. DR. F. W. Ross, of Chemung county, said that there was less reason. for general practitioners making such mistakes, than the regular examiners in lunacy, as the former were usually appointed, in these cases, by the court, to make an examination, and usually obtained a correct history ; while the examiners in lunacy commonly know nothing previously about the case, and those brought to them for examination represent all nationali- ties and languages. DR. J. C. HANNAN, of Rensselaer county, said that in his neighborhood there was a woman who had a drunken husband. When this man would return from his debauches, he would abuse his wife, and he finally threatened to send her to an insane asylum. This went on for a year or two, when the husband employed two local physicians to examine his wife, and these men pronounced her insane, a commitment was made. out, and she was sent to a very well-known institution in the State. She remained there six or seven months. Her sister came to the speaker and asked him if he had any influence with the physicians of this institution, as her sister was not in the least insane, and was constantly writing to her to: try and get her out. After six or seven months, she was discharged as Sane. In view of these facts, he would like to know why this woman was detained, if she were not insane when admitted to the institution. Since her discharge from there, she had nursed a patient for him, and she appeared both physically and mentally in a normal condition. THE PRESIDENT replied that the fact of her being discharged as same was prima facie evidence that she was insane when admitted. Again, there might have been much more in her history than was known to the speaker, but which the physicians in the institution had learned subse- quent to her admission. MITRAL STENOSIS IN PREGINANCY. By ZERA. J. LUSK, M.D., of Wyoming County. November 17, 1892. The question of matrimony among women having un- mistakable organic disease of the heart, can admit of but one answer, and that, emphatically in the negative. Rarely is a physician’s consent or advice sought by the contracting parties, for the very reason, in the first place, that nearly always the disease is unsuspected, as there are no rational signs denoting a perverted state of health; and Secondly, if there were, the young Juliet would prefer taking the chances of married life, rather than the Opprobrium of ultimately evolving into that state which bears the euphonius title of “old maid.” Under the subject of cardiopathia and pregnancy, Dr. Parvin' quotes Jaccoad as asking the question : “Has the patient suffered from the cardiac lesion ?” If she has never suffered, he sees no reason to forbid marriage, but adds: “Her social condition must be considered. If she has to work during pregnancy, then much is to be feared ; but if she can be properly cared for, follow medical advice, and pass the last half of her pregnancy in almost absolute rest, she may marry.” Jaccoad further relates a case in his private practice, where a young lady had for eighteen months ardently desired to marry, and that, had a negative answer been given, mortal Syncope might have followed. The fallacy of such an argument is too apparent. The chances of mortal syncope following a refusal to permit marriage, would be more favorable than syncope attend- * “Annual of the Universal Med. Sciences.” 380 NEW YORK STATE MEDICAL ASSOCIATION. ing the cardiopathic in the pregnant state. The aug- mented duties of the married woman, the painful con- Sequences following pregnancy and maternity, and the alarming infant mortality, should be sufficient to dis- Suade the most sanguine, and to clear all doubts about entering the married state. It would be a great error to assume that a woman could safely marry, if not suffering at the time from the valvular disease. If stenosis of the mitral valve be present, serious trouble will certainly develop as soon as the heart is called upon to perform the increased work incident to the last months of preg- nancy. The demands upon the maternal system begin about the six month, and subsequent to this time, great changes continually occur. The enormous development Of the gravid uterus with its intricate vascular apparatus, as well as the growing foetus, call for an increased amount of blood, the normal constituents of which are undergoing change, the solids being proportionately diminished. While there is an augmented supply of blood, “the frequency of the pulsation of the heart re- mains unchanged. For this alternate contingency, dila- tation of the cavities becomes a necessity, and for the same reason, arterial tension is increased.’” It is evident that the heretofore weakened heart must begin to show evidence of overwork. Mitral stenosis is essentially a disease of women and children, and the majority of cases owe their origin to the rheumatic diathesis. It is sometimes dependent on a form of chorea resulting from neurotrophic disturb- ances. Loomis” asserts that such cases are confined to children, and recover after a few years. Duroziez” dis- Courages the theory that mitral stenosis, pure and simple, is of rheumatic origin, and records eight cases occurring in children, but adds: “They were subject to rheumatic attacks later in life.” * Lusk's Treatise on Midwifery, page 98. * Pepper's System of Medicine, Wol. III., page 666. "Annual of the Universal Medical Sciences, Vol. I., 1888, page 192. MITRAL STENOSIS IN PREGINAWOY. 381 The object of this paper is not so much to discuss the aetiology of mitral stenosis, as to consider the manage- ment of such cases in actual practice. They are almost always emergency cases, desperate in character, and demanding the best energy and most prudent manage- ment from the physician. Fortunately they are of rare occurrence. In the last eighteen years I have had up- wards of twelve hundred cases of labor, and out of this number only two of mitral stenosis. There has been the usual number of those who gravely assert that they have heart disease and cannot take anaesthetics; also of those whose physicians have accepted their statements with- out making careful physical exploration, yet in whom a careful examination fails to discover the physical signs of cardiac disease. Sir Andrew Clark' describes six hundred and eighty-four cases of valvular disease occur- ring in his private practice, in the year 1887, and says “that in a large majority of these cases the disease was unsuspected.” The symptoms of mitral stenosis are few, They are described by Loomis as “mainly characterised by a loud churning, grinding, or blubbering presystolic murmur. It is of longer duration than any other cardiac murmur, On account of the time required for the blood to pass through the narrowed and obstructed orifice. It ends With the commencement of the first sound. The apex beat being synchronous with the purring thrill, the mur- mur is heard with its maximum intensity a little above the apex beat.” CASE I. On May 5, 1890, I was called to see Mrs. R-, a primipara, thirty-one years of age, well developed, and weighing about one hundred and thirty-five pounds. Her environment was all that could be wished. I Was informed by her husband that she was seven and a half months ad- Vanced in pregnancy, and that she had been unusually well until about a *onth before, when she began to have more or less nausea, and to suffer from obstinate Constipation. I learned that her brother, who was a grad- uate of the University Medical College of New York, but not at present *&^ged in the practice of medicine, had occasionally seen and advised her. * Ibid, page 667. 382 NEW YORK STATE MEDICAL ASSOCIATION. Indeed, up to this time no other medical aid had been sought. I found her sitting up ; her face was pale, and there was almost constant retching, with occasional vomiting of whitish mucus tinged with bile. The stomach re- jected everything taken, even water; her pulse was rapid and weak; res- pirations hurried, tongue moist, and covered with brown fur ; breath Offensive ; bowels had not moved for several days. She also complained of sleeplessness. I advised an enema of warm Soap and water, a sinapism over the epigastrium, and cracked ice as required. I also gave her, every fifteen minutes, one teaspoonful from a mixture consisting of fifteen drops of the fluid extract of ipecac to one-half glass of water. In my experience this has often relieved the distressing nausea of pregnancy when other remedies have failed. To the question whether she had any heart disease, she gave a negative answer, and said if her bowels could only be relieved she would be all right. I also left a powder of sulfonal to procure sleep. On the following day her husband informed me that the enema had given a negative result, but that the nausea had been relieved and she had rested better, and was more cheerful. I was requested to consult with her brother, Dr. Gouinlock, whose idea of the case was that “she has been wearing very tight-fitting corsets, and is now paying the penalty.” As he considered her symptoms due to pressure of the gravid uterus on the other organs, he could suggest nothing to relieve her condition. I advised com- pound cathartic pills to move the bowels, and a dessert-spoonful every two hours of a mixture of one teaspoonful of bi-tartrate of potash in a glass of water. I did not see her at this time, and not again until Friday evening, the 8th, when I was hastily summoned. She was in bed; countenance pale and pinched; pulse 130, rapid and weak; respirations, 38; constant retching, marked dyspnoea, no oedema of the extremities. I advised a hypodermic injection of one-fourth of a grain of morphia and one one-hun- dred-and-fiftieth of a grain of atropia; but Dr. Gouinlock informed me that the family were very susceptible to morphia, and objected to giving more than one-tenth of a grain. I considered that her condition of extreme prostration required more heroic treatment, and advised the doctor to re- peat the dose until complete quiet was secured. No examination of the heart was made at this time; patient was very restless, tossing about in bed. Urine showed no trace of albumen. Dr. G. was left in charge during the night. I was hastily called again about one A. M. because Mrs. K– had “a sinking spell.” On my arrival I found her in extreme collapse; no pulse at the Wrist, respirations slow and intermittent. I learned that she had continued to be restless up to a few moments before the attack, and that suddenly the body became rigid, and she had a general tonic spasm. The heart was now beating tumultuously, and nothing but a churning sound could be heard. At this juncture Dr. M. D. Mann, of Buffalo, N. Y., was summoned by special train, and arrived in about two hours. In the meantime I had administered chloroform with the result that the color had gradually returned to the face, the heart action had become more steady; the pulse appeared at wrist, and when spoken to the patient moved her eyes. On examination of the heart, there was a loud presystolic mur- MITRAL STENOSIS IN PREG WA. WCY. 383 mur, with an occasional clacking Sound ; on palpation, a distinct “purring thrill” was communicated to the hand. Digitalis and brandy were given hypodermically. Under this treatment her condition continued to improve and things began to look more hopeful, when suddenly the eyes were drawn upward and the head backward, and the whole body remained in a tonic spasm for about two minutes. Respiration was apparently sus- pended; the beating of the heart became loud and tumultuous; cold per- spiration again appeared upon the face and extremities, and she had every appearance of rapidly sinking. However, the muscles soon began to relax, and under chloroform inhalation the heart became less tumultuous and the color returned to the face. At this time I made a vaginal examination and found the os dilated so as to easily admit the middle and index fingers. Under chloroform, I dilated the cervix still more. Dr. Mann then arrived, verified my diagnosis, and continued the treatment. About four A. M. there was another spasm, lasting about one minute. She rallied slowly from this. Dr. Mann continued the dilatation sufficiently to permit the application of the Tarnier forceps, and soon delivered a still-born male child. The mother did not rally, but gradually sank, and expired about five A. M. CASE II. Mrs. H., a well developed primipara, twenty-nine years of age, had had one miscarriage at three and a half months two years before, She was poor and obliged to work. She was seven months advanced in pregnancy, and had done well up to two weeks before, when she had “a fainting spell,” as she termed it, followed by nausea and vomiting, which had continued up to the time I was called. She had also been troubled with a hacking cough. Her tongue was covered with a moist brown fur; the breath was very offensive ; bowels constipated ; the pulse 140 and ir- regular. She also had dyspnoea and sharp precordial pain. On palpation, there was a distinct purring thrill communicated to the hand, and diffused OVer apex ; there was no increased area of dullness. Near the apex there Was a loud and prolonged presystolic murmur, and the apex beat was Synchronous with the purring thrill. Dr. Loomis' holds that mitral steno- sis depends upon the existence of two physical signs, viz.: “The purring thrill, and a loud, long, blubbering presystolic murmur.” The os was found sufficiently dilated to easily admit the index finger. She was put to bed, an enema prescribed, and one-sixth of a grain of morphia with One One-hundred-and-fiftieth of a grain of atropia given hypodermically. She was also given brandy and digitalis hypodermically, and on the fol. lowing day, aromatic spirits of ammonia by mouth. On the morning of the 13th, there was dyspnoea, the pulse was 120, the temperature 99° and the heart's action less tumultuous. She continued to improve and on the *5th I discontinued daily calls. I advised them fully of her condition, and of the necessity of her keeping quiet. I was again hastily summoned on the night of the 6th of January, and was informed by messenger that she had been doing some light work, and found her in complete collapse; no 1 Pepper's System of Medicine, 3d vol., page:667. 384 NEW YORK STATE MEDICAL ASSOCIATION. pulse at wrist, respirations rapid, and every indication of impending dis- solution. Brandy and digitalis were given Subcutaneously, and chloro- form by inhalation. Under the influence of the chloroform, reaction was soon established. She had three slight attacks of syncope during the night, but each time the inhalation of chloroform was followed by an ameli- oration of the distressing symptoms. I saw her several times on the 26th, and instructed the nurse about giving chloroform, if syncope threatened. On the morning of the 27th the nurse reported that the patient had slept some during the night, and had had only one attack of fainting. Her pulse was 126, respirations 32, temperature 99°, and she complained of a good deal of nausea and dyspnoea. She said she had felt no foetal move- ments for two or three days. The os was found dilated so as to easily ad- mit two fingers; there was a vertex presentation, but no evidence of foetal life. In the evening her pulse was weaker, respirations 40 and labored, and her temperature 99°8. The nurse reported that the patient had had slight chills during the day. The OS was found already dilated to two inches, and in about two hours there were regular uterine contractions. Stimulants were given every two hours, and with the aid of a little chloro- form I dilated the cervix, and delivered with forceps a female child, which had evidently been dead for several days. After the tenth day convales- cence proceeded satisfactorily, and she was able to be about and attend to household duties in about six weeks. Now, in the first place, both of these patients had had attacks of rheumatism in childhood, but were not aware of the existence of any cardiac lesion. The first patient, suspecting that she had heart disease, had said that she would not allow herself to be examined for that trouble. I did not examine the heart at my first visit ; I should have done so. “Experience sometimes teaches dear lessons.” It matters not what the condition of the pregnant woman, or at what period the physician is called, he should always examine the heart, and so be pre- pared for any emergency, or be in a position to prevent, if possible, any complications arising from the existence of a cardiac lesion. I was dissuaded from examining her heart by the assurance that she had no such trouble, and attributed her prostration to lack of sleep and to the obstinate vomiting. The cases of Sir Andrew Clark prove the fallacy of accepting the statement of patients. Secondly. I believe that the only safe treatment prior to the fifth month, when mitral stenosis is present, is the production of abortion. Dr. Mann, who was present, MITRAL STENOSIS IN PREGA WA WCY. 385 * fully concurred in this opinion. In both cases there was no impairment of health before the sixth month. It is at this time that heart weakness begins, and even if the pregnancy be allowed to proceed, the chances are that the foetus will not survive the last two months. Children, whose mothers are the victims of cardiac disease, are often imperfectly developed, and are predis- posed to untimely death. Thirdly. The salutary effects of chloroform, cautiously administered so as not to produce full anaesthesia, were most perceptible. In both cases, the chloroform, when thus administered, temporarily improved the pulse and color of the face, and gave an opportunity for other and more permanent medication. Fourthly. If the sixth month is already past, the patient must remain at perfect rest, under the constant Care of a physician, and her husband or the nurse in- Structed in the use of chloroform. In answer to various questions, Dr. Lusk said that he had used the word “syncope” in lieu of the word collapse. He had meant to say that the patient was in collapse. At this time there were only churning sounds of the heart to be heard, but as soon as the inhalation of chlo- roform began, this tumultuous action was greatly dimin- ished, and her general condition improved very rapidly. This good effect was noticed after each inhalation of chloroform. The second patient was not so strong as the first one, yet there was a decided improvement when she Was Only sufficiently under the chloroform to feel the Stimulating effect. DISCUSSION. PR. F. W. Ross, of Chemung county, said that he could not accept the author's conclusions in regard to premature labor, for there is fully as much danger in abortion as in allowing a woman to go on to full term. He *alled one case of undoubted mitral stenosis which gave him much cause for ºnxiety when he first saw her at about the sixth month of pregnancy. Not Wishing to induce premature labor, he only cautioned her to notify 25 386 JNETW YORK STATE MEDICAL ASSOCIATION. him immediately when labor began. When she notified him, he promptly dilated the os, and by the aid of forceps, without assistance or anaesthesia, delivered her of a living child, and she made a good recovery. Two and a half years later, he attended her in her third pregnancy. As soon as the pains began, he was summoned, and at once dilated the OS, and again, without anaesthesia or medical assistance, delivered her of two living chil- dren. She also made a good recovery from this confinement. One should be careful about suggesting the induction of premature labor in any case of cardiac disease, for, as a rule, these cases do well, even though present- ing quite an unfavorable appearance. DR. JoHN CRONYN, of Erie county, said that the histories of the cases reported showed that, when young, they had suffered from rheumatism. The long continuance of a condition like rheumatism must necessarily be attended by hypertrophy of the right auriculo-ventricular opening on that side, and mitral stenosis. The author did not mean “syncope,” but a condition of collapse occurring with an irritable heart; and the reason the chloroform acted so favorably was because it allayed this irritability. He could endorse the whole treatment, except the use of digitalis. Digitalis is a peculiar drug, and in mitral stenosis, with hypertrophy, he did not think it was a good medicine. It did no harm in the author's case, because he gave it along with brandy. 3. DR. F. W. HrggiNs, of Cortland county, said that not long ago he had had an interesting case in which abortion had occurred spontaneously five days previously. When he first saw her, there was evidence of heart- failure, but he could not detect any “thrill” or other evidence of mitral Stenosis, and he made a diagnosis of fatty heart. In his opinion, the latter months of pregnancy are the more dangerous, and, therefore, if labor can be induced while the patient is still strong, the result is more likely to be Satisfactory. In the case referred to, the woman was very anxious for a child, and she was allowed to go on until the sixth or seventh month, when labor came on spontaneously; yet, for a long time after her confinement, her life was in great danger. DR. LUSK, in closing the discussion, said that he stated in his paper that about the sixth month there is an augmented supply of blood, and a greater demand made upon the heart, due to the development of the foetus, and, therefore, this is the most dangerous period. The physician who first as- sisted him said that his wife had mitral stenosis, yet, although she had had a baby every year for ten years, the speaker could not discover, on examina- tion, any of the symptoms or signs of valvular trouble of the heart. Dr. Mann said to him that he always recommended the induction of premature labor where there was evidence of mitral stenosis, and though the mother might live, the chances were one hundred to one against the child. DR. S. T. ARMSTRONG, of New York county, called attention to the fact that the author had particularly emphasised the evtent of the stenosis. He was at present treating a lady who had been under observation for the past ten years. Mitral stenosis existed before her first pregnancy, and, although DISCUSSIOW. 387 she has been pregnant five times, the degree of stenosis is but little more than it was when she first came under observation. She is not now under treatment with cardiac tonics, and has never taken digitalis, so that had abor- tion been attempted in her case, it would have served no good purpose. The circumstances of the patient must of course not be overlooked. They were such in his patient as to subject her at no time to any strain or anxiety. She has been seen in consultation by several obstetricians, who agreed that there was no indication for the induction of labor. Her last child is now a healthy boy about sixteen months old. He had considered the case worthy of narration, because it had been under observation for so long a time. In some other cases, he had given chloroform without any more hesitation than for any general surgical procedure. He agreed thoroughly with Dr. Cronyn in condemning the use of digitalis, and in recommending brandy. DR. LUSK said that he could not say that he got any effect from the dig- italis in this emergency case; the good result was probably due to the brandy and the Strychnia. THE USE OF ELECTRICITY IN MIDWIFERY. By OGDEN C. LUDLow, M.D., of New York County. November 17, 1892. It requires no very great stretch of imagination to fancy the more conservative among you saying to them- selves, as they glance at the title of this paper: “I sup- pose some young enthusiast is going to try to make us believe that electricity is capable of doing almost any- thing in midwifery, and that our time-honored drugs and instruments must be thrown aside, and Our Obstetric out- fit reduced to a battery and a few electrodes.” If there be any such here to-day, let me relieve their minds at once by stating that it has been the aim of the author to avoid the rosy-hued descriptions so often indulged in by writers upon the medical uses of electricity, and to con- fine his paper to a concise and scientific statement of some points which his own experience has led him to think may be of practical interest to his fellow prac- titioners. There are many occasions on which the resources of the obstetrician are taxed to the utmost, and Our Science has not yet become so exact that we can say, with cer- tainty, that this or that remedy will be the appropriate one for a given case. Even the physician of large ex- perience, who has learned to make the most of what is at hand, cannot afford to ignore any measure, however trivial, which has been found helpful in practice; and it is hoped, therefore, that the value of electricity in mid- wifery will be judged, not by theory, but by the actual test of experience. It is not an agent which will suit every case, or which can be applied according to mathematical rules; like other therapeutic measures, it THE USE OF ELECTRICITY IN MIDWIFERY. 389 frequently fails, but, nevertheless, it possesses certain important advantages which, in the opinion of the writer, entitle it to a permanent place in the recognised resources of obstetric art. Whenever the generic term “elec- tricity” is employed in this article, it is to be under- stood that it refers to faradisation, as this form of elec- tricity is by far the most useful, as well as the most con- venient for Our purpose. For convenience in description, its more important uses may be considered under three heads, viz.: I. Its sedative action. II. Its oxytocic action. III. Its power to prevent and to control uterine haemorrhage. I. Its Sedative Action.—Happily, public opinion no longer considers it improper to attempt to relieve the sufferings of the parturient woman, and those physicians who still persist in withholding remedies which are known to mitigate the pangs of childbirth, do so, not because they believe that woman is doomed “in sorrow to bring forth children,” but from a deep conviction that the administration of such drugs is not for the best good of their patients. At our last meeting, I took occa- Sion to express myself as heartily in favor of the judi- cious administration of chloroform in most cases of labor, but I recognise that chloroform has some disadvantages, and I am sure that all of us would gladly welcome any agent which, while exerting a marked sedative effect, Would not interfere with the progress of labor, or tend to produce post-partum haemorrhage. Such an agent is to be found in the faradic current of electricity, but you will be disappointed if you expect it to exhibit this action in every case. I regret very much that my own experience With faradisation does not permit me to endorse the claims made for it by Dr. W. T. Baird, of Texas. In an article written by him, and published in the American Journal of Obstetries in 1885, he says that the suffering can be as effectively relieved in the painful parts “as 390 NEW YORK STATE MEDICAL ASSOCIATION. we would dare to relieve it with anaesthetics for any great length of time,” and adds that he has never known of a case in which it has failed to give all the relief demanded by the patient. This is pretty strong lan- guage, and is only applicable to some of the more strik- ing cases which have come under my observation. In his experience with electricity in midwifery, the writer has met with the same uncertainties and disappointments which characterise the action of other remedies, and he has thus far been unable to formulate rules which would be of much assistance in determining which cases are most appropriate for its use. In Saying this, however, he does not wish to be understood as implying that it is more difficult of application than such remedies as chlo- roform, morphine, and chloral; but only that in this field, as elsewhere in medicine, empiricism must play an important part. - Dut, you ask, what are the special advantages, then, of electricity over other remedies' In the first place, it is useful where chloral or morphine is contra-indicated on account of idiosyncrasy or debility, or where it is not considered prudent to push these drugs any further. It is also available where the stomach is too irritable to re- tain medicine, and where it is inconvenient or impracti- cable to resort to rectal administration. Faradisation, unlike morphine or chloroform, does not interfere with the progress of labor by stopping “the pains,” but, On the contrary, excites more powerful and efficient uterine contractions, at the same time that it quiets the general nervous irritability. It also possesses the distinct ad- vantage of not favoring uterine relaxation and haemor- rhage, and its use, therefore, does not complicate sub- sequent operative procedures under anaesthesia, should these be demanded. The manner in which the faradic current produces sedation has long been a fruitful subject for specula- tion, yet, up to the present time, but little is definitely known about it. The older writers compared its action THE USE OF ELECTRICITY IN MIDWIFERY. 391 on the nerves to that of counter-irritants upon disease processes; or, in other words, they claimed that, by pro- ducing a profound impression upon the nerves of sen- sation, it prevented them, for the time being, from trans- mitting the sensation of pain. More recently we have been told that it probably causes anaesthesia by pro- ducing a sort of rapid inward percussion upon the nerves. That the number of vibrations of the current have much to do with its anaesthetic effect has been admirably shown in a recent paper, read by Dr. William F. Hutch- inson, of Providence, before the American Electro- Therapeutic Association. He has had constructed an in- duction apparatus, in which the usual spring vibrator has been replaced by a metallic ribbon, which may be readily adjusted to vibrate in unison with any desired note ; and his experiments upon the human subject with the current from this apparatus have brought out the re- markable fact that, when this ribbon sounds the note of C major, or is vibrating about thirty-two thousand times per minute, the maximum anaesthetic effect is obtained. So marked was the anaesthesia that he was enabled, in one instance, to open a felon without causing the patient any pain whatever. I mention these experiments, not only because they throw some light on the action of the faradic Current upon the sensory nerves, but because they show plainly that we cannot expect to obtain this exceedingly useful effect of the current from every little induction apparatus which we may happen to employ. II. Its Oaytocic Action.—If there be one action of elec- tricity more certain than another, it is its power to evoke and stimulate uterine contractions; hence, in every case of tedious labor in which the delay is due to feeble or infrequent contractions of the uterus, or where, owing to slight disproportion between the foetal and maternal parts, unusual muscular exertion is required to deliver the child, faradisation is indicated, and will usually - render efficient aid. Not infrequently the exhibition of its sedative action is immediately followed by a distinct 392 NEW YORK STATE MEDICAL ASSOCIATION, advance, thus showing that, in practice, its Sedative and oxytocic actions cannot always be separated. In persons of sensitive temperament, a slight benumbing effect, whether produced by drugs or by faradisation, is suffi- cient to encourage the patient to “bear down '’ more vigorously, and so make better use of the “pains” of the second stage. One of the most beneficent properties of electricity is exhibited in what may be termed its “steadying effect” on “the pains,” by which is meant that the uterine contractions, when severe and almost incessant, are made less frequent and more efficient. It is just here that one appreciates the importance of that rest which is afforded the uterus when the contractions are of the regular rhythmical type seen in a perfectly normal labor. - Notwithstanding all that has been written and said against the danger of administering ergot to hasten labor, there are not a few practitioners who persist in this prac- tice. To these physicians, as well as to those who are often sorely tempted to use it in this way, but who have moral courage enough to refrain, I would recommend a trial of faradisation. The action of ergot is slow, and un- certain in degree ; faradisation produces its effect instan- taneously, and the amount can be accurately gauged. Ergot exerts its influence for a variable length of time, which is entirely beyond control; faradisation acts upon the uterus for just so long a period as the operator de- sires—it can be instantly checked, and as quickly re- sumed. Ergot produces a tonic cramp of the uterine muscle, which unnecessarily exhausts the mother, and is dangerous both to her and to the child ; faradisation produces a steady, rhythmical contraction of the uterus, which allows a proper interval of rest to the uterine muscle, and closely imitates Nature’s method. In no class of obstetric cases does electricity possess such sig- nal advantages over other and better known measures as in that in which a safe, speedy and certain oxytocic agent is indicated. I say” “indicated,” because there THE USE OF ELECTRICITY IN MIDWIFERY. 393 are many cases, besides those due to simple inertia of the uterus, in which such an agent is desirable. Thus, there is often a slight narrowing of the pelvis, or the foetal head is unusually large, or is abnormally Ossified, causing a tedious labor, and yet, at the commencement, it is im- possible to say whether or not delivery can be safely effected without instrumental aid. Under such circum- stances, it is true conservatism to make an effort to ac- complish delivery without resorting to instruments or to an operation, and this is especially so when that effort does not involve any additional risk. No evidence has yet been brought forward to show that electricity, as ordinarily applied, is harmful, either to mother or child, so that one has nothing to lose and everything to gain from a trial of its oxytocic properties. Faradisation is likely to prove very useful in those Oc- casional cases in which the induction of labor becomes imperative. On account of the comparative rarity of this procedure, only one such case has come under my personal observation in which this agent was so em- ployed, but, in this instance, its action was so admirable as to place it far in advance of the methods usually recommended. In cases of inevitable abortion and mis- Carriage, it is also an extremely valuable agent; but this will be again referred to in considering its action in the third stage of labor. * III. Its Power to Prevent and to Control Uterine Haem- orrhage.—Under this head will be considered more par- ticularly its usefulness in the third stage of labor. As in all cases where uterine inertia already exists, or is likely to be present, there is danger of haemorrhage in the third stage. The indication is to employ such treatment as Will place the uterus in the best possible condition to Prevent such a mishap. The usual practice is to do little *9te in the way of prophylaxis than to guard against undue exhaustion of the patient, and to avoid emptying the uterus too rapidly. The best authorities advise *śainst the use of ergot until it is certain that the second 394 NEW YORK STATE MEDICAL ASSOOIATION. stage of labor will be completed within a very few minutes, and many prefer waiting until the child is delivered before administering this remedy. The writer prefers the latter plan, and is of the opinion that the giving of ergot a short time before delivery is often responsible for difficulty in removing the placenta. This objection does not apply to the use of electricity, for, as has been already stated, the contractions of the uterus which it produces are entirely under the control of the operator. Among the more common causes pre- disposing to post-partum haemorrhage may be men- tioned rapid emptying of the uterus, and the use of chloroform to the point of producing profound an- aesthesia. Where there is imperfect contraction of the uterus after the delivery of the placenta, or where post-partum haemorrhage is imminent or is actually present, faradisation is very useful, and when the haem- orrhage is not excessive may be all that is required. I do not wish to be understood as advocating its use in the face of an alarming haemorrhage, to the exclusion of well recognised methods of treatment, for this might mean the loss of valuable time, and, perhaps, even of a life; but, if the electrical apparatus be in readiness beforehand, as it should be, it will be found a valuable adjuvant to other methods, just as a hypodermic injec- tion of ergot may give temporary aid after the obstetri- cian has removed any portions which may have been retained in the uterus, and when, perhaps, a few precious moments would otherwise be lost while hot water for a douche was being brought to the bedside or its tempera- ture was being adjusted. Electricity is also useful in aiding the expulsion of the placenta. Most obstetricians will be able to recall cases in which, owing probably to fat abdominal walls, or, still more commonly, to distension of the bowels with gas, the placenta has been delivered only after considerable manip- ulation, which has left the abdomen sore and tender. By calling electricity to our aid, we shall be able, in most THE USE OF ELECTRICITY IN MIDWIFERY. 395 cases, to expel the placenta with scarcely any manipula- tion of the abdomen, and with a trifling loss of blood. Analogous to the assistance rendered by electricity in the third stage of labor, is its action in cases of abortion. Here, it may be resorted to with good effect, saving much time and annoyance, both to patient and physician, by doing away with the necessity for prolonged manipula- tions, and so diminishing both the dangers and the dis- comforts attendant upon such accidents. For instance, in those cases of early abortion, occurring in women in whom the cervix is high and the ostium vaginae quite small, it need hardly be said that the removal of the contents of the uterus is often attended with much difficulty, yet it is just under such conditions that fara- disation does yeoman service ; for it not only causes the expulsion of the contents of the uterus, but also guards against One of the most common complications, i. e., haemorrhage. From what has been already said, one would very nat- urally and properly infer that electricity would be useful in cases of sub-involution, and while this is true, the limits of this paper prevent a consideration of this, and such kindred subjects, as the use of faradisation to stimulate the Secretion of milk, or for the relief of the vomiting of pregnancy. It has been the object of the writer, thus far, to give a general idea of what may be expected from faradic elec- tricity in obstetrical practice. It remains now to con- sider briefly, a few illustrative cases, and then take up Some practical points regarding the technique of its ap- plication. As some of the following cases were observed in hos- pital practice, jointly by Dr. Irwin H. Hance and myself, I am indebted to him for some of the clinical notes: CASE I.—A good SEDATIVE AND OxYTOCIC ; PROMPT CONTROL OF POST- PARTUM HAEMORRHAGE AFTER FORCEPS DELIVERY. Ipara; tWenty-eight years of age. The first stage lasted twenty-one hours, and the pains were fifteen or twenty minutes apart. At the begin- 396 NEW YORK STATE MEDICAL ASSOCIATION. ning of the second stage faradisation was begun, and was kept up almost continuously for forty minutes. The pains were then more vigorous, and came on about every five minutes, yet the electricity produced a marked Sedative effect, which was commented upon both by the patient and the nurse, although I had been careful to refrain from saying anything about. the severity of the pain. The current was then applied for some little time longer, but only during the pains, which became somewhat less frequent. again, but still quite strong. The head was obstructed at the pelvic floor, and after waiting a considerable time, the forceps were applied under full chloroform narcosis, and delivery effected in twenty-five minutes. The tonic contraction of the uterus was not very good after the delivery of the placenta, and there was a small gush of blood, which was instantly checked by the application of the electrode. CASE II.-A GooD SEDATIVE AND oxyTocIC. II para; twenty-two years of age. The first stage was characterised by almost constant knagging pains, and after some hours, although the patient was quite plucky, she became very nervous, and her pulse rose to 120 beats per minute. At the time of beginning the faradisation, the os was about two and a half inclues in diameter, thick, and unyielding, and the head of the child was quite high in the pelvis. In from three to five min- utes it was evident that the patient was suffering much less, although the uterine contractions were frequent, short, and sharp. In a few minutes more the os was fully dilated, and the head on the perinaeum, and the child was delivered in half an hour. The electricity was applied at inter- vals during this period until just before the delivery of the head. The patient had become quite calm, her pulse had been reduced to 104, and was of better quality, and the uterine contractions were much more regular and effective. CASE III.-A GooD SEDATIVE AND OXYToCIO ; USEFUL IN THE THIRD STAGE ; EFFECT OF WARYING THE INTERRUPTIONS IN THE CURRENT, Ipara; twenty-five years of age ; a large and strongly built woman. The dilatation of the os was very slow, so that thirty-six hours after the first pains began, it was only about two inches in diameter. Seven hours later, notwithstanding the use of several hot vaginal douches, and the evacuation of considerable liquor amnii, the os was not much larger, and the pains were irregular, short, and inefficient. The full strength of the current from a large faradic battery was then applied in the usual way, and after about fifteen minutes of almost continuous application, the pains had become more regular and frequent, and had increased in severity, yet the patient was much quieter, and expressed herself as experiencing much less pain. The application of the current lasted for half an hour. After this, the progress was more decided, and the os was fully dilated in a little less than four hours. There was slight obstruction to the descent of the head in the pelvis, so the forceps were applied, aud the head soon delivered by gentle intermittent traction. There was some little difficulty in delivering the placenta, and its expulsion was followed by more than the usual THE USE OF ELECTRICITY IN MIDWIFERY. 397 amount of bleeding, and although this was checked by ergot and hot douches, the uterus remained flabby. The faradic current was again ap- plied for about five minutes, with the result of causing a firmer contraction of the uterus, and preventing further haemorrhage. In this case, it was found that the most work could be obtained from the current with the least inconvenience to the patient, by adjusting the contact-breaker So as to make very fine interruptions during the intervals of the pains, and changing to coarse interruptions as soon as the uterus began to Contract. CASE IV. —PROLONGED FIRST STAGE FROM RIGID OS ; FARADISATION FAILS BOTH AS AN OXYTOCIC AND A SEDATIVE , CEILOIRAL SUC- CEEDS. Ipara; twenty-one years of age. She had pains at short intervals for four days before any dilatation of the os was evident. When the os had reached two inches in diameter, there was scarcely any further progress. The uterine contractions occurred every three minutes, and were very strong, but with each pain the os would dilate to nearly the full size, and then contract to its former size when the pain subsided. During the night the patient received three hot vaginal douches, and thirty grains of chloral, but with little benefit. A strong faradic current was then applied, almost continuously for fifteen minutes, and then only during the pains, for fifteen minutes more. The uterine contractions then became very severe, and re- Curred every two minutes, but there was no advance and no sedation, and the faradisation seemed to cause so much discomfort, that it was stopped. During the next four hours, the patient received three hot vaginal douches, and thirty grains more of chloral. She then came pretty well under the influ- ence of the drug, and at the same time, it was noted that the child's head Was lower, and that the cervix was receding. The progress of the labor from this point was uninterrupted, and the child was born two hours later. This case is worthy of special notice, not only because of the failure of electricity to accomplish good results under conditions which seemed theoretically to be pecu- liarly appropriate for its use, but because it also shows that the writer does not wish to convey the impression that electricity will accomplish wonders in every case. Contrast this case with the following: 9ASD V-good oxytocic Action, AND some sedation; chlor:AL FAILs. ſpara; twenty-eight years of age. The first stage was quite slow, the 9s being only about one inch in diameter at the end of twenty-four hours. º Cervix was thin for a long time before the os dilated, and the head was 9W down in the pelvis, but the pains were not very strong. Chloral failed 398 NEW YORK STATE MEDICAL ASSOCIATION. to assist the dilatation. The faradic current was applied continuously for twenty minutes, and produced some sedation. The second stage began fifteen minutes later, and was completed in half an hour. CASE WI.-MARKED SEDATION, ALTHOUGH NO EFFECT UPon THE Os; PELVIC CONTRACTION ; FORCEPS DELIVERY. Ipara; twenty-five years of age. After being in the first stage for twenty-four hours, suffering severely, it was found that the os was only about two inches in diameter, and its margins quite thick. There were severe uterine contractions every five minutes, and hot douches and mor- phine had given no relief. Faradisation was employed continuously for thirty minutes, with the effect of producing more efficient uterine contrac- tions at longer intervals, and causing the entire disappearance of the knag- ging pains in the back and hypogastric region. After the second stage was reached, it became evident that the mother would require assistance, so the forceps were applied, and delivery effected. This case is presented in order to show that even in the presence of pelvic deformity, relief from pain may be obtained by the use of electricity, when morphine in appropriate doses has failed. In view of the fact that, in such cases, it is probable that an operation under an anaesthetic will ultimately be required, it is obvious that it is safer to apply electricity, than to administer chloral or chloroform. . CASE VII.— INDUCTION OF LABOR IN FIFTEEN MINUTEs, BY FARA- DISATION. This patient, a primapara, thirty-one years of age, with a decidedly phthisical family history, had suffered for a long time previous to her pregnancy, from gastritis, and had been further debilitated during preg- nancy, by persistent nausea and vomiting. After her admission to the hospital she rejected all stimulants and food, with the exception of a little milk and carbonic acid water. In view of her wretched and somewhat precarious condition, it was decided after consultation that, as the Com- puted time of her confinement had arrived, it was not advisable to wait any longer, and that labor should be at once induced. On the day she had expected to be “sick,” there were no uterine contractions, and no indica- tions of the onset of labor; the os only just admitted the tip of the finger, the vertex presented in the L. O. A. position, and the foetal heart Was beating strongly. The patient was very weak, and excessively nervous and apprehensive. The electrodes were applied in the usual manner OVer the sacrum and abdomen, and the strength of the faradic current adjusted so as to be slightly disagreeable, but not painful. While the current W* being applied, Dr. Hance attempted digital divulsion of the OS. The first uterine contraction occurred four minutes after applying the current, and THE USE OF ELECTRICITY IN MIDWIFERY. 399 several others followed in rapid succession. At the end of twelve minutes from the beginning of the application the OS had dilated sufficiently to ad- mit two fingers. Faradisation was then stopped for a few minutes. In twenty-five minutes from the beginning of the seance the os admitted three fingers and was quite dilatable, and the pains were returning regu- larly at intervals of three or four minutes. In the next twenty-five minutes the current was applied only during the uterine contractions. The pains were now only two minutes apart, the mother was much more com posed, and her pulse was 68, regular, and fairly good. Labor being now well established, faradisation was discontinued. The first stage lasted four hours, and the second only thirty minutes. CASE WIII.—ExPULSION OF THE PLACENTA BY ELECTRICITY; LESS THAN THE USUAL BILEEDING. Ipara; twenty-one years of age. The faradic current was applied only during the pains near the termination of the second stage, and was then omitted for about five minutes, until the umbilical cord had been ligated. On again closing the circuit, the uterus promptly contracted, and in a moment the placenta was forced into the vagina. Although chloroform had been administered sparingly during the last few expulsive pains, the delivery was attended with practically no haemorrhage. About three years later I attended the same lady in confinement with her second child. The first and second stages together only occupied a little over two hours, chloroform was given in the same way during the last fifteen minutes of the Second stage, and faradisation was not employed at all. There was considerable more blood lost than at her first confinement, when the elec- tricity was used, but the amount still did not exceed that found in many normal deliveries. CASE IX.-HOUR-GLASS CONTRACTION ; ADHERENT PLACENTA ; FARA- DISATION FAILS. Ipara; thirty-three years of age. After applying the current for a reasonable time, it was found that the expulsion of the placenta was hin- dered by a contracted ring in the lower segment of the uterus, and also by the placenta itself being adherent. An examination of the placenta after delivery showed its cotyledons to be unusually large and soft. No ergot had been administered. CASE X.—PLACENTA EXPELLED ; IMMEDIATE ARREST OF A SLIGHT POST-PARTUM HAEMORRFIAGE. - iº Ipara; twenty-five years of age. An application of the faradic current * the usual way caused the prompt expulsion of the placenta from the uterus into the vagina, and then, very gentle downward pressure with the electrode resulted in the placenta being immediately forced outside of the vulva. Just after stopping the current there were a few gushes of blood from the uterus, but this haemorrhage ceased immediately on closing the circuit again, and after a few minutes the uterus remained firmly con- tracted without artificial aid. 400 NEW YORK STATE MEDICAL ASSOOIATION. The foregoing cases are representative ones, and have been selected with the object of showing what electricity can do and what it cannot do in the practice of mid- wifery. Looking over those cases, of which I have pre- served careful notes, and in which electricity has been employed with a specific object in view, I find that in twelve cases in which faradisation was employed for its sedative and oacytocic effects, its sedative action was shown in eight, and its oxytocic action in nine cases. In twenty out of twenty-seven cases, in which it was em- ployed in the third stage of labor, it materially aided the expulsion of the placenta, and in three out of four cases of moderate bleeding, occurring immediately after delivery, it promptly checked the flow and produced firm uterine contraction. . No doubt by this time some of you have been thinking that this employment of electricity in midwifery is pretty in theory, and, perhaps, useful in hospital practice, or where there are more facilities for using electrical appar- atus than ordinarily fall to the lot of the general practi- tioner, but that it is of very doubtful application to the every-day routine of practice. I hope to show that such is not the case, and that the effects described in this paper may be obtained without the use of any elaborate, expensive, or cumbersome apparatus. I find no objec- tion to the treatment on the part of the patients or their friends. On the contrary, they are gratified at the effort the physician makes to relieve the suffering, and are not slow to compare this practice with the more common One of sitting at the bedside and turning a deaf ear to the patient's pleadings. Do not misunderstand me on this point. I am no advocate of “meddlesome midwifery,” but I do believe that the accoucheur should stand ever ready to assuage the sufferings of childbirth whenever this can be done with safety to the mother and child; and while leaving much to Nature, he should be Con- statly on the alert to see when art can aid her. If in a Severe and prolonged case of labor we can safely reduce THE USE OF ELECTRICITY IN MIDWIFERY. 401 the patient's sufferings and conserve her failing strength by causing the pains to come at longer intervals, and then to do more efficient work, it is certainly our duty to do so. Chloral, we know, will accomplish much under such circumstances; but let us not forget that electricity may do as much, or more, and with even less risk to our patients. The needful appliances are, a portable faradic battery, two or three electrodes, and the necessary conducting cords. It is all important that the battery should be so constructed as to require very little attention while in operation, and also when not in use. It is desirable that the contact-breaker should be capable of nice adjustment, so that the current may be “made ’’ and “broken’’ evenly ; and just here, I would say that it would be a great advantage to the obstetrician to have the usual contact-breaker replaced by the new “singing rheotome” which Dr. Hutchinson has devised for the purpose of making very rapid vibrations. This instrument, as I have already said, has only just been brought to the notice of the medical profession, but I feel quite con- fident that had I had it at the time I was attending the cases described in this paper, the sedative effects of the current would have been still more remarkable. As, in a general way, it may be said that a current from a coil of coarse wire is the most appropriate for stimulating muscular fibre to contraction, and that from a fine wire coil most suitable for producing sedation, it is desirable to have the faradic apparatus provided with such coils. Where, however, one desires to have a very small battery Which can be carried in the coat-pocket or in the obstet- ric bag, some of these refinements must be sacrificed to portability. A very useful machine of this class is the One known as “the Smith & Shaw Closed Cell Battery.” It is not nearly so dirty and wasteful as the well-known Gaiffe pocket-battery, and is in every respect a much more efficient instrument. The current is sufficient for most cases, but even the coil with two cells of battery, is, 26 402 NEW YORK STATE MEDICAL ASSOCIATION. in exceptional cases, hardly strong enough. It can be carried about charged, so as to be ready for use at a moment’s notice. Each charge is sufficient to run the battery for a number of hours, and its renewal is quickly and easily effected. The best method of applying the current to the patient is with the positive pole to the sacro-lumbar region, and the negative pole to the abdomen. Fairly good work can be done with two sponge electrodes applied to the abdomen on either side of the uterus, but this method is not so convenient or so effective as the One first described. The only precaution necessary in regard to the position of the electrodes is to place them so that the current will not pass through the head of the child. The method described will avoid such a danger in vertex cases, but where the breech presents, it is better to apply one pole to the sacro-lumbar region, and the other to the nape of the neck. For the lumbar electrode, I use a small copper plate, to which is attached the conducting cord from the positive pole of the faradic machine. The portion of the cord near the plate should be covered with rubber tubing, so that it may be easily cleaned. When the electrode is to be applied, it is laid upon a strip of roller bandage and a thin sheet of wet absorbent cotton is wrapped around both the plate and bandage. The bandage is then fas- tened around the patient like a belt, and serves to retain the electrode in contact with the skin and in proper posi- tion, even though she be rolling about the bed. It matters not if the electrode be soiled with the discharges, for the rubber-covered cord and the copper plate are easily cleaned, and fresh absorbent cotton and bandage are used for each case. Unless very powerful currents are required, the best abdominal electrode is the Opera- tor's hand, as he is kept constantly informed concerning the strength of the current, and more important than all, he can keep the uterus in his grasp. This will be pal- ticularly appreciated by any one using faradisation in THE USE OF ELECTRICITY IN MIDWIFERY. 403 the third stage of labor, for with an ordinary sponge electrode, it is a very easy matter for the uterus to relax and escape around one or the other side of the electrode. Where the hand is used, the Operator takes an Ordinary sponge electrode in one hand, while the other is applied to the abdomen, Or, the conducting cord from the nega- tive pole is connected to a metal band fastened to his wrist. The objections to this method of application are the weariness it produces in the Operator's hand and arm, and the fact that if the current be sufficiently strong to be effective, it is very disagreeable to some persons who are especially susceptible to its influence. The best sub- stitute for the hand is a flat sponge, insulated at the back with a piece of sheet rubber. In Selecting such an electrode, it is important to see that the back is very flexible. Another method is to connect the negative cord with a small metal ball, which is placed in the centre of a large Sponge. The Operator can then grasp the Sponge with the naked hand, or can protect his hand with a rubber glove. Before beginning the application one should always be Careful to see that both electrodes are well wetted with Warm water, that the strength of the current is reduced to the minimum, that the contact-breaker is adjusted to Work smoothly, and that the current is turned off from the electrodes. Both electrodes are then placed in Position, the current turned on, and its strength very gradually increased until it is distinctly perceptible to the patient, but causes no pain. The circuit should be kept closed for ten or fifteen minutes, when the sedative effect should be evident. When this is once obtained it IS only necessary to keep the circuit closed during the Pains. When used for its oxytocic effect the current should be strong enough to be disagreeable without *ing decidedly painful, and should be applied inter- *ittently in imitation of the normal rhythmical con- "actions of the uterus. When it is desired to employ electricity in the third stage of labor to facilitate the 404 NEW YORK STATE MEDICAL ASSOCIATION. delivery of the placenta and to encourage firm uterine contraction, the circuit should be closed as soon as the child is delivered, and a mild current applied to the uterus. Unless it is evident that this will cause the expulsion of the placenta prematurely, the current need not be broken. If the uterine contraction be sluggish the strength of the current should be rapidly increased, when there will usually be a sudden and powerful con- traction sufficient to expel the placenta. It must be remembered that adipose tissue is a very poor conductor of electricity, and that, therefore, in women with fat abdominal walls, the results are likely to be very dis- appointing unless powerful currents are employed. To recapitulate: (1). The necessary apparatus is neither complicated nor troublesome. (2). The application of electricity in cases of midwifery requires no special technical skill, and is, therefore, applicable to the needs of the general practitioner. (3). Electricity exhibits its sedative effect in parturi- tion sufficiently often to make it worthy of trial where the physician is reluctant to administer chloral or chloroform. (4). Electricity assists labor by increasing the force and efficiency of the natural uterine contractions. It is prompt and reliable, and is entirely under the control of the Operator. (5). The use of electricity in the third stage of labor aids the expulsion of the placenta, and diminishes the risk of haemorrhage. - In conclusion, the writer ventures to express the belief that every physician who may be induced to give electric- ity a fair trial in his obstetric practice will find in it a valuable ally, but one which no more deserves to be Con- sidered infallible than do the other remedial agents at Our command. THE RóLE OF MICROBES IN DISEASE. By N. B. SIZER, M.D., of Kings County. November 17, 1892. At a former meeting of this body, I had the honor to discuss the “Ptomaines,” or “Leucomáines.” By your favor I am again permitted to address you upon the present state of our knowledge of microbes as causes and accompaniments of disease. - The word “microbe” means any minute living thing ; while the words “bacterium,” “bacillus” and “coccus” refer to the shape of the organism as being like a rod or staff, or berry-shaped. There is a general misapprehension, even in our pro- fession, regarding the nature of bacteria. Bacteria and their congeners are not animals, although they may be close to the border-line of the two kingdoms; they are undoubtedly vegetables, although mobility is one of their characteristics. As we study our subject we shall see that microbes do harm, not so much by the local irritation due to their presence in the tissues, as by excreting, during their life, poisons called “leucomáines.” Some of these substances are, Weight for weight, twenty to thirty times as poison- OuS as Strychnia or aconitia. These virulent bodies are called “leucomáines” when formed in living bodies; when set free after death by the microbes of putrefaction they are “ptomâines” (Greek— Pºoma, a corpse). A general name applied to them all is “toxine,” or “animal alkaloid.” It is to their absorption that the symptoms of most bacillary diseases are due. Anthrax (“wool-sorter's disease,” “charbon,” “milz- brand”) is common in herbivora, and is transmitted by 406 WEW YORK STATE MEDICAL ASSOCIATION. them in various ways. When infection occurs through a scratch or bite, an early resort to excision or the cautery may destroy the germs before systemic infection has occurred. Sometimes dust loaded with spores is inhaled by those who handle dry hides, hair, and wool from infected beasts. Here the lungs contain the primary foci of infection, and very little can be done for the unfortunate victims. This disease has been an awful scourge, France at one time losing millions of sheep and cattle every year, and yet the most skillful veterinarians were absolutely helpless. Although, as I have said, the herbivora are very suscep- tible to this disease, the carnivora generally are immune ; but if, for example, rats are temporarily fed on a veget- able diet, they will become as susceptible to anthrax as rabbits, but will again become proof against this disease when fed exclusively on flesh. Fowls are almost entirely immune, probably because their temperature is naturally high, for if we reduce the bodily temperature two or three degrees centigrade, for a few hours, by keep- ing the legs and lower part of the body in ice-water, they may be successfully inoculated with this disease. Pollender seems to have first seen the bacilli in 1849, in the blood of cattle. One year later Davaine redis- covered them and was first to demonstrate their meaning, which he did in 1863–4, before the Academie Française, where he proved that the blood of sick beasts was full of these germs, and that inoculation of a minute frag- ment of dried or fresh blood was followed by rapid death, the blood of the inoculated animal being the habitat of myriads of the characteristic rods of charbon, which were plainly visible under the microscope. Pasteur has made thousands of pure cultures, and finds progeny as vigorous as the parent stock, even to the hnndredth successive generation. The microbe is “aerobic,” or lives on oxygen, like animals, and the power of infection resides wholly in the rods, as filtered cultures are harmless. THE RóLE OF MICROBES IN DISEASE 407 The Sudden deaths in certain microbic diseases are fully explained by what we know of their wonderful powers of reproduction ; thus, certain species divide once every hour. At this rate the total progeny in twenty-four hours would be 16,777,220, or almost seventeen millions, and at the end of forty-eight hours, 281,500 millions; and at the end of a week a row of fifty-one figures would be needed to express their numbers An average oacillus is a cylinder one-five hundredth millimeter long by one one-thousandth millimeter wide, and one cubic-millimeter (a space only the one-twenty- fifth part of an inch high, wide and deep) will comforta- bly contain about 633,000,000 of them. At the end of the twenty-four hours the progeny of one such microbe will occupy only one-fortieth part of the cubic-millimeter, but after forty-eight hours it will need 442,570 such cubic-millimeters to hold them, or say half a litre. If Our Oceans cover two-thirds as much space as the land, and average one mile in depth, the cubic-contents will be about 928 millions of cubic miles. By a short calcula- tion it is easy to show that the number of microbes present at the end of about five days, and expressed by a row of fifty-one figures, would require so much space that they would fill all our terrestrial oceans up to the brim— almost a thousand millions of cubic miles | We need not wonder, then, that in anthrax, with the blood full of countless myriads of microbes which feed On Oxygen, these mischievous parasites consume so much of the vital gas that it is abstracted from the blood more rapidly than the lungs can replace it, and that, therefore, the poor patient has urgent dyspnoea, cyanosis, and a Subnormal temperature, and dies of asphyxia. { { One of Koch’s most useful discoveries was that of the resting-spores” of anthrax. These are highly refrac- tory bodies which are developed in the rods and have ºnormous vitality, even resisting prolonged immersion * Strong alcohol, long boiling, complete dryness and Putrefaction, while the rods succumb to them all. 408 NEW YORK STATE MEDICAL ASSOCIATION. Spores are not found during life, but develop in the rods during the early stages of putrefaction, and take their place, so that dried blood containing these spores may be as virulent as fresh blood containing the rods. A dead body, full of spores, continues to be a source of contagion for an unlimited time, owing to the earth- worms which feed on the remains and leave their “casts” on the surface of the ground for the wind and rain to scatter the spores over the herbage, and so communicate the infection to grazing animals. Pasteur has succeeded in so attenuating the bacilli by starvation that gradual inoculation renders animals im- mune to anthrax. No wonder, then, that France has showered such wealth and honors upon Pasteur, for, aside from the human suffering and death thus averted, this discovery saves six or eight millions of francs to France every year. CHOLERA ASIATIC A. The cholera germ is a “spirillum,” and when broken up into its component parts, is found to be a thickish, slightly curved, mobile bacillus ; hence its sobriquet, “comma bacillus.” Its mobility, when free, is due to its long flagella, growing from one end only ; by means of this it sculls its way through liquids. It was first found by Koch, in India. The photograph I now present, amplifying the bacillus about 1,000 diameters, demonstrates the flagellae admir- ably; you will note that some bacilli have two of them, while in others they are bifid. The “rice-water” dejecta contain these microbes in such immense numbers that they have been called a “pure-culture” of the B. Cholerae Asiaticae, but in the later stages the microbes penetrate into the mucous membrane and tubular glands of the intestines. It is safe to say that we have cholera only when the “comma” microbe is present; it is absent in all other THE RöLE OF MICROBES IN DISEASE. 4.09 conditions, no matter how apparently “choleriform '’ the symptoms. Other curved bacilli are abundant in the mouth, but cultivation proves at once that they are not the true cholera bacilli. The lower animals, so far as we now know, are usually immune. In the Hamburg epidemic, last summer, the microbe was found growing abundantly in the city water, and in the soil wherever cases of cholera had appeared. In cultures the bacilli grow in colonies of several hun- dreds, adhering end to end, and so twisted as to produce a “spirillum,” that is, a spiral colony, like a cork-screw in shape, having from ten to fifteen complete spires or coils. The “comma” shape is caused by each individ- ual retaining the slight curve which it had while living in its colony. These “spirilla” are curious sights indeed, as they slowly propel themselves along by revolving each upon its axis, just as a cork-screw works its way through a cork. You see, therefore, that the cholera spirillum is the original screw-propeller, and long antedates Ericsson. It has of late been suggested that the B. Coli Com- Tnumis may be a sort of quiescent form of the “comma” microbe. IERYSIPELAS. This is a bacillary disease, because certain cocci are always found in the tissues. They are extremely abun- dant in the newly-attacked oedematous parts, have been isolated and cultivated, and when pure cultures have been inoculated, have successfully reproduced the disease in both men and animals. After inoculation the classical Symptoms develop after an incubation period of from fifteen to sixty hours. ..This germ is a streptococcus (i. e., growing in chains like a string of beads), which is always present in *mmense numbers, especially in E. Vagrams. A drop of Serum from the peripheral oedema is the best place to 410 NEW YORK STATE MEDICAL ASSOCIATION. look for them, the oedema being due to the fact that they are so abundant as to literally cause thrombosis of the lymph spaces. DIPEITHER.I.A. Microbes were seen in diphtheritic exudates as long ago as 1868 by Oertel, Bahl and Hueter, and Ziemssen wrote! “It is not diphtheria if the microbes be absent l” Klebs and many others have isolated and grown pure cultures, and have, by inoculation, caused a rapid growth of the cocci all over the body. Chickens and cats often die of a similar disease during epidemics of diphtheria in human beings. GON ORR][[OE A. This is caused by Neisser’s “gonococcus,” described in 1879. It has been found in pus from the urethra and vagina, and from ophthalmia neonatorum, but never in pus from other sources, or in simple leucorrhoea, or ure- thritis; so that, if present in abundance, the nature of the case can no longer be doubtful. In certain German obstetric charities, ophthalmia ne- onatorum formerly appeared in about eight to twelve per cent. of all the newly born ; but since the adoption of systematic ante-partum disinfection of the maternal va- gina, and the careful cleansing of the conjunctival Sur- face in the babies as soon as born, with the instillation of a weak silver-nitrate solution, this disease has been much less frequent. Thus, in a clinique of eight Or ten thousand accouchements per annum, where formerly there were from eighty to one hundred and twenty cases of ophthalmia neonatorum each year, there has not been a single case in the last three or four years. RARIES. Pasteur's researches in rabies are well known, so that it is sufficient here to say that careful cultivation has 1 Vol. I., p. 590. THE Róſ, E OF MICROBES IN DISEASE 411 produced a very concentrated fluid, known as “labora- tory virus,” which is six or eight times as virulent as the ordinary virus of “street rabies.” By repeated in- oculations with this virus, and by drying the spinal cords of the animals so treated, the virus becomes suffi- ciently attenuated to use for protective inoculations. The following statistics show what has been done: The deaths from rabid dog-bites average 25 to 35 per cent., but out of 10,992 persons inoculated by Pasteur during 1886–91, only 62 succumbed, or slightly more than one-half of one per cent. Of wolf-bites in the head, always very fatal, 82 per cent. die. Pasteur had under his care nineteen Russian peasants thus bitten ; of these, three died before the inoculations were completed; the other sixteen at last accounts remained well. What can be nearer a specific than this 2 MALARIA. This whole class of complaints has been ascribed to the presence in the body of the B. Malariae, a discovery of Klebs and Tommasi-Crudeli; though our own Salisbury, I believe, claims that honor. Doubtless more than one organism may exist, for it Seems generally agreed by those who have seen it that the dreadful “Roman Fever” of the Campagna, which has made a desert of what was once the most productive and beautiful region of Italy, differs essentially from Such cases as we commonly observe in this country. LIEPROSY. Leprosy has been admitted definitely into the class of bacillary affections because the B. Leprae is found con- Stantly present in the tubercles. This bacillus was dis- °ºvered by Hansen, in 1879, and many successful cases of inoculated lepra have been published. MEASLES. The bacterium of Cozé and Feltz, so far as we know, *ms always to be present in this familiar disease. It is 412 NEW YORK STATE MEDICAL ASSOCIATION. an extremely minute, very mobile microbe, which is found in immense swarms in the rapidly fatal so-called “malignant’’ types, and in very small numbers in the milder cases. Pure cultures have been made and inoculated, and although the lower animals do not seem very susceptible, a few successful cases have been reported. PLEURO-PINEUMONIA. This often occurs epidemically among animals, under the familiar name of the “Epizootic.” As human beings Often coincidently suffer, I do not hesitate to mention it here. The parasitic microbe of this disease was seen first by Williams, about 1852. This was probably the first bacillary disease in animals to be purposely propagated for the sake of the acquired immunity, as this was done in New York and vicinity more than thirty years ago, in the time of the famous “swill-milk?” panic. PNIEUMONIA. This is now admitted to appearin a distinctly infectious form, and all such cases have been proved to be caused by the presence of the pneumo-coccus of Friedländer. This germ is constantly found in the lungs in all cases of acute croupous pneumonia, and is also believed to be the cause of various suppurative processes independently of pneumonia, e.g., primary ulcerative endocarditis, purulent cerebro-spinal meningitis, and certain severe cases of purulent otitis. When present in the pus from Such cases, a cautious prognosis should be given, as owing to the wandering habits of these cocci, they in- vade the lymph channels, and infect the mastoid cells, and even the meninges. According to Goldenburg, this pneumococcus is to be found in fifty per cent. of all healthy mouths, and in a!! mouths for weeks after pneumonia. It is easy to see how THE RöLE OF MICROBES IN DISEASE 413 they can migrate to the frontal sinuses, by the tuba Eustachii to the ear, and through the lymphatics to the brain cavity. I am often asked, why, then, do we not all get pneu- monia ; and why does it so often apparently follow a severe chill after exposure ? I answer, no seed, however good, grows if the soil be not adapted to it; and exposure to cold and wet will lower our resistance to the invading pneumococci in the same way that chilling the legs of a fowl will render it susceptible to anthrax. IRELAPSING FFVER. The spirillum of relapsing fever was discovered by Obermeier in 1868. It lives in the vascular system, and during the pyrexia the blood is full of them ; but they disappear instantly and completely as soon as deferves- cence occurs. These facts show us that the fever is due to the presence in the blood of a brood of these spirilla and to the absorption of the “toxine’’ which they excrete. When the brood dies the toxine ceases to be formed, defervescence ensues, and the patient suddenly recovers. This microbe has been grown, pure cultures produced, and monkeys inoculated there with, with the result of reproducing the fever with all its peculiarities. SC AIRLATIN A. Definite proof of the bacillary origin of scarlatina is not yet at hand, but it is all but settled. RAIBBIT SEPTIC AIEMIA. I mention this disease, though not a human ailment, from its curious history and the light thrown by it upon other pathological conditions. It was discovered accidentally by Sternberg, in Sep- tember, 1880, and by Pasteur in December of the same year. It was found that a few drops of healthy human Saliva injected into a rabbit would produce a rapidly 414 NEW YORK STATE MEDICAL ASSOCIATION. fatal form of septicaemia, due to the presence in the saliva of the “B. Cuniculicidus ; ” and wonderful to relate, rabbits previously inoculated with any other microbe, no matter what, were totally proof against the Saliva bacillus ! Some saliva is very fatal, a couple of drops killing in forty-eight to sixty hours; usually life is prolonged for three or four days. Pure cultures are much more virulent because stronger in microbes; but if filtered, the filtrate being germ free is absolutely innocuous, thus proving the microbes to be the cause of the disease. - Now for the practical application of this knowledge. It is well known that the venom of serpents is derived from a gland, similar in all respects to our salivary glands, and that, therefore, the venom is saliva, more or less modified by development. Do not the results of a snake-bite explain, not only these cases of Saliva-Septicaemia, but also the frequent deaths and more frequent amputations following that most dangerous injury, a “man-bite,” the analogue, as I take it, of Serpent poisoning . SYPHILIS. As a germ disease, syphilis is still doubtful, but the famous “fuchsine bodies,” once called “artefacts,” are now supposed to be parasitic. The great obstacle to success is the difficulty of cultivating any microbes thus far found, for man alone seems susceptible to inocula- tion. TU BERCULOSIS. We have at last returned to the faith of our fore- fathers, and to-day consider consumption, in One sense, an infectious disease. In 1882, Koch announced his discovery of the tubercle bacillus, not at all to the surprise of pathologists. Since then, by sterilising the sputa of phthisical persons, isolating bad cases, and forbidding these patients to THE RóLE OF MICROBES IN DISEASE 415 disseminate their sputa broadcast, after the time-honored fashion, the mortality from this disease in the German army has been reduced to one-quarter the former rate. The air of rooms where consumptives live, is full of microbes, and the dust adhering to the walls has been found loaded with the B. Tuberculosis, so that a few particles thereof, injected under the skin, or blown into the lungs of animals, will soon cause death from that disease. Our ideas of “scrofula.” have been greatly modified ; what were formerly called “strumous joints’’ are found to be nests of bacilli, and the same is true of many en- larged glands, all caseous deposits, and lupus nodules. Diagnosis and prognosis now largely depend upon what the microscope reveals, and in this connection I may mention that Ehrlich’s method of starving the tubercle bacilli is the easiest and most certain. Out of 2,509 cases of Supposed phthisis, observed some years ago, the tubercle bacillus was found in 2,417. I need say little of “Tuberculin.” If this “toxine’’ does no more than act as an “indicator” in lupoid dis- eases, it deserves immortality as being unique in the history of medicine. TETANUS. This awful disease is especially frequent in the tropics, Where, especially in India, half the babies succumb to trismus nascentium before the end of their second week of life. . It is caused by Nicolaier's bacillus, found everywhere in cultivated soil, in stables, and on and about horses. For this reason, the majority of those affected with tetanus are stablemen or drivers. Horses are very subject to tetanus, and often contract it from human beings. It is supposed that the ground is kept infected by manuring it. Many cases follow a wound where dirt has been rubbed in, so that it is probably not so much ”/8/y nails as dirty nails which are likely to infect Wounds, and cause tetanus. 416 IVEW YORK STATE MEDICAL ASSOCIATION. The same microbe is present in trismus nascentium, as Beumer has isolated it, and caused tetanus by inocu- lation. The microbe resembles that of rabies, the virus residing mostly in the bulb and cord. It can be similarly atten- uated, and is also most active after sub-dural inoc- ulation. - The rule of contagion is: man to man, very seldom ; from animals to man, very often ; man to animals, often; from soil to men and animals, very often. TYPHOID FEVER. The stools in typhoid fever abound in Eberth’s B. Ty- phosus, which thrive in water, and in hundreds of cases have thus infected the water supplies of cities and towns, causing the death of thousands. The terrible epidemic at Plymouth, Pa., is still fresh in our minds, where too few were left to care for the sick or to bury the dead. So far as now known, most animals are immune. The bacillus abounds in Peyer’s patches, the mesenteric glands, and on the mucous membrane of the small intes- times, and is always present in this disease. Hence, intestinal antisepsis is, in my opinion, the best treat- ment; and phenol, or preferably, salol, should be the antiseptic agent selected. This treatment, in a series of seventy-five cases, was followed by prompt deferves- cence, and a disappearance of all faecal odor from the stools. The alkaloid which is produced is “Typhotoxine,” and this, by its systemic intoxication, causes the fever and the various typhoid degenerations. A filtered cul- ture contains no germs, but its repeated injection into a rabbit produces fever and other symptoms, and after death the intestinal glands are found to be congested. If the typhoid bacilli are mixed with a rabbit's food he sickens, and at last dies, with all the physical and ana- tomical signs of typhoid fever. THE RöLE OF MICROBES IN DISEASE 417 VARIOLA AND WACCINIA. We cannot, as yet, cultivate these germs outside of the body, but when we do succeed in obtaining pure cultures, the last support will be taken away from that criminal folly—anti-vaccination. WELOOPING COUGH. Paulet discovered his microbe in 1867, cultivated it, sprayed the culture into the tracheae of rabbits, and pro- duced the characteristic spasmodic cough of pertussis. Tschamer, of Gratz, repeated these tests, inhaled the spores himself, and in eight days whooped violently, and his sputum was found to be full of the growing colonies. Many others have repeated these experiments with the same results. This explains the good effect of phenol, in sprays or when administered by mouth, and also the benefit derived from inhaling the fumes from a gas- house. YELLOW FEVER. Sternberg is somewhat doubtful as to the microbe of this disease, but Freira and Carmona are more confident, the latter naming his organism. “Peronospora Lutea,” and both of them claiming very successful results from inoculations with attenuated cultures. MICROBES IN SURGERY. Pyaemia is a general invasion of the body by the pus Cocci, while septicaemia is a systemic intoxication pro- duced by the absorption of the toxines or leucomáines Set free by the microbes of decomposition. Puerperal fever is often due to contagion, and always to sepsis When it arises spontaneously, set up usually by putrid matter in the uterus and vagina. “Latent Gonorrhoea,” the specialty of the late Dr. Noeggerath, though often ridiculed by old fashioned Practitioners, “who never owned a microscope and Wouldn’t know a germ if they saw it,” to quote Dr. Noeggerath’s own words to me, is an excellent example 27 4.18 NEW YORK STATE MEDICAL ASSOCIATION. Of what damage a few dangerous spores may do in the life of a previously healthy woman. There can now be no doubt that this is the cause of a great deal of pelvic disease. Osteomyelitis is caused by its special germ, already cultivated by Pasteur and reproduced in animals, while malignant Oedema is due to Koch’s “B. Oedematis Mo- ligmi,” and “Swine-fever’’ to Klein’s “B. Pneumo-em- teritis,” while the “Madura Foot,” of India, has a well marked special organism, named from its discoverer, “Chronypha Carteri.” - Actinomycocis, the “big head” or “big jaw” of our cowboys, is due to the growth in the body of the fungus “actinomyces,” whose spores are found on herbage gen- erally, but which are harmless until they gain entrance through a wound. Men have taken it from picking their teeth with a stem of grass or straw, and thus wounding the gums. “Chronic Leucorrhoea,” is always accompanied by the “micrococcus albicans Amphes” of Bumm, who has made pure cultures, and by inoculating them in the vaginae of monkeys has reproduced the disease. In operative surgery, how important are the microbes | Pyaemia, hospital gangrene, and half-a-dozen other pests, Once the surgeon’s perpetual dread and nightmare, are now seldom seen, and experience has taught that if the microbes are kept out of wounds they heal without pain, fever or suppuration, and all sorts of major operations may be done with the almost certain prospect of speedy recovery. Our immense canning and refrigerating industries de- pend on the discovery that fermentation and decompo- sition are due to micro-organisms, and that all that is needed to preserve food indefinitely is to keep out the germs. Nowadays ships leave New Zealand with thirty thousand carcasses of sheep aboard; refrigerating ma" chines, at work day and night, keep the hold at or below the freezing point, and mutton can in this way be THE RöLE OF MICROBES IN DISEASE 419 delivered in London Or Liverpool in prime condition, and sold to consumers at about half the price of English- grown meat. - Let us now consider Some of the recent accessions to our knowledge of microbes, and their relations to disease. We find that B. Tuberculosis is far from being a hardy plant; its cultivation is tedious, and it is easily killed, even by a bright light. This explains why the best-lighted rooms in barracks and prisons have less than their proper average of cases of phthisis, and vice versa. For years the fact that many simple exploratory laparotomies in cases of tubercular peritonitis have been followed by recovery, has remained a mystery. But it is a mystery no longer—the light was too much for the bacilli, and caused their death. Exploratory incision is now deliberately done in these cases, an incandescent lamp being introduced in order to thoroughly expose all the viscera to the bright light. In my former paper* I have discussed the question of poisonous food “toxines”, so fully that I shall only refer now to “Tyrotoxicon.” This has been proven to be the cause of cholera infantum, and arises from fer- mentation of milk in dirty bottles, nipples and tubes. For years many of the more enthusiastic bacteriologists in this part of the State have been getting excellent re- Sults in cholera infantum by the administration of half a milligramme of the bichloride of mercury every three hours. At the end of seventy-two hours we expect to find that 75 to 85 per cent. of our cases have assumed the character of a simple diarrhoea. The green stools of nursing children are almost a pure culture of the microbes of “Tyrotoxicon.” I must not forget the phagocytes, or wandering cells, whose duty it is to devour the disease microbes which invade the body. Thus, in a diphtheritic exudate we find on its surface almost a pure culture of the Klebs- Loeffler bacillus; in the deeplayers we find very few, but * Trans. N. Y. S. Med. Assn., Vol. W., p. 102. 420 JNEW YORK STATE MEDICAL ASSOCIATION. plenty of phagocytes stuffed full of half-digested bacilli. The “toxine'' of these microbes is a powerful poison, and causes the well-known nerve-cell degenerations, whence arise multiform paralysis and frequent heart failure. All these have been produced in a rabbit by the continued injection of the “toxine,” although not One microbe was present in his body. The curious fact has been noted that a microbe, harm- less in itself, may become fatal if injected in company with another equally harmless microbe. Again, if we poison an animal by one “toxine,” he is made thereby Subject to quick death from an inoculation of the same microbe. This shows why people already ill with typhus fever, or tuberculosis, are so apt to have multiple ab- cesses, for they become infected with the common sup- puration cocci found in the air. All our mucous cavities swarm with disease germs, but they are kept off by the intact epithelia and the vigilant phagocytes. If we weaken these guardians, a local disease first appears; and if the phagocytes be too few, or are weakened by previous disease or constitutional inheritance, systemic infection follows. The moral is, keep the skin clean and free from cracks, cuts, and other solutions of continuity; clear out harm- ful microbes by normal alvine evacuations. Headache and bad taste in the mouth, so constantly present with torpid liver and bowels, are due to “toxines” absorbed from the intestine. You will find that attacks of furun- culosis can be quickly cured by brisk laxatives and keep- ing the intestinal tract aseptic for a few days. Ana- logous to this is Sir Andrew Clark’s discovery that chlorosis is a “toxine” poisoning—a “stercoraemia,” as he calls it—due to chronic constipation. So you see the old saw has yet teeth to it, which bids us keep our heads cool, our feet warm, and Our bowels soluble; though we give its ancient wisdom a new namº and now call it “applied bacteriology l’’ ABDOMINAL HYSTERECTOMY FOR MYOMA. By FREDERICK A. BALDWIN, M.D., of New York County. Movember 15, 1892. In the latter part of June, Dr. Sinnett brought to me Kate W., born in the United States, single, twenty-five years of age. Her family history was good. Five years ago she began to have pain in the right iliac region, beginning ten days before menstruation, and ceasing as soon as the flow was established. This continued every month up to the time of the Operation, the pain during the past year being more severe, and the flow of blood more profuse. She was under medical treatment more or less during this time, but without relief; she was losing flesh, and complained of being tired. Upon examination, we found the uterus enlarged, the Sound entering the cavity four and one-half inches, and by palpation a growth could be readily made out. The diagnosis at this time was a fibro-cystic tumor of the uterus. The patient was informed that an operation would have to be done, and its serious character fully explained to her. She was put on tonic treatment and sent to the Country for the summer. She returned on September 5th, looking and feeling much better. On examination it was found that the tumor had increased about twenty- five per cent. during the previous nine weeks, so im- mediate operation was advised. Accordingly she en- tered St. Elizabeth's Hospital on September 12th. On the following day she was examined by Dr. S. J. Walsh, Pr. J. H. Sinnett and myself, when we concluded that a hysterectomy Would have to be performed. That evening 422 NETW YORK STATE MEDICALL ASSOCIATION. she was given a purgative, and as this did not act sufficiently, she was given a laxative pill the next night and a bath of bichloride of mercury the next morning, For her breakfast a bowl of bouillon was given at seven o’clock. All the instruments used during the operation had been previously boiled for twenty minutes. At eleven o’clock on the morning of September 14th, Dr. Sinnett etherised the patient, and the parts were then shaved, and made thoroughly aseptic. She was placed in the Trendelenburg posture, and with the assist- ance of Dr. S. J. Walsh, and Dr. Valentine Mott, the operation was begun by making the usual median inci- sion, three inches in length ; the abdominal cavity was opened, and the fingers passed around the tumor. There were no adhesions, but it was found necessary to enlarge the incision to six inches. The tumor was then brought outside the abdomen, and wrapped in towels wrung out of a hot Thiersch’s solution ; the intestines were covered with flat sponges and pads of gauze moistened with the same solution, and these were frequently changed dur- ing the operation. s An elastic ligature was placed around the cervix, and a transfixion pin passed just above it. The tubes were ligated and cut, and the uterus removed. There was quite a free haemorrhage from the broad ligaments, which was controlled by continuous sutures of catgut. The patient became so weak at this time that a hypoder- mic injection of whiskey was given, and this was re- peated eight or nine times during the operation. A V-shaped section was taken out of the stump, and the cervical canal obliterated by the thermocautery; the sides of the stump were then brought together with sutures of twisted silk. On removing the elastic ligature and pin, there was slight bleeding from the stump, which was controlled by sutures of silk. The pedicle Was dropped back. As the patient was suffering greatly from shock, the abdominal cavity was hurriedly, but thor- oughly, washed out with hot Thiersch's solution, a glass ABDOMINAT, HYSTEREOTOMY FOR MYOMA. 423 drainage tube introduced, and the cavity filled with the same hot solution and Sewed up in this condition with silver wire Sutures. The condition of the patient was such that I did not feel warranted in taking the time to bring the peritonaeum and fascia together with buried sutures. She was wrapped in hot blankets and placed in bed with bottles of hot water around her. It was then two hours since beginning the ether, and the amount of ether used was five-eighths of a pound. The shock was extreme ; radial pulse imperceptible, and the patient in a condition of collapse. She was given one-quarter of a grain of strychnia, one-hundredth of a grain of atropine, and one-sixth of a grain of morphine hypodermically, and an enema of one ounce of whiskey and two ounces of hot water. For the next three hours free stimulation was continued, and she improved slightly. At half-past four o’clock her pulse was 138, respira- tions 15; and at this time, three ounces of red fluid were taken from the drainage tube. One hour later her condition was so much better, that a small quan- tity of hot water was given by the mouth ; and at Seven o’clock, whiskey and hot milk were given by the rectum, but were not retained, and patient had a Small stool. As she complained of great thirst, hot Water was given in small quantities by the mouth at frequent intervals. At nine o’clock, her temperature was 101.5°, pulse 136, respirations 20. The urine was drawn by catheter, and One and a half ounces of red fluid taken from the tube. At ten o’clock she was bright and cheerful; at eleven o'clock she voided urine. She was then perspiring; her temperature was 101.5°, pulse 134, respirations 20. Six drachms of lighter colored fluid were taken from the "be. She complained of pain in the wound, and was 8 Wen one-sixth of a grain of morphia hypodermically. She passed a comfortable night, and at seven o’clock in *morning had a movement from the bowels. Her tem- 424 JNEW YORK STATE MEDICAL ASSOCIATION. perature was 100.5°, pulse 128, respirations 17. During the day, the fluid was removed from the tube every two hours. She had a full natural movement from the bowels, and took a little whiskey and milk. At six o'clock her temperature was 99°, pulse 112, respirations 15. From this time on, all nourishment was given by the mouth. For the next twenty-four hours she had whiskey and milk, then beef tea, and on the fourth day after the operation, eggs were added to her diet. In the evening the first dressing and tube were removed, and the edges of the wound brought together with plaster and a dressing of iodoform and moist bichloride gauze applied. She slept over four hours during the night, and at nine o’clock the next morning her temperature was 99°, pulse 96, respirations 16. She passed a comfortable day; nourishment was given every two or three hours, and at ten o’clock the next evening her temperature was 100.2°, pulse 104 and respirations 16. For the next eight days, she had an evening temperature ranging from 99.5 to 100°, but after the sutures were removed, it did not go above 99°. She had no distention of the bowels, but as a precau- tionary measure, she was given one drachm of Sulphate of magnesia, which produced the first nausea since the operation. In the morning she was given a Seidlitz powder, and later one drachm of sulphate of magnesia, which she vomited in a few minutes. At eleven o’clock she had three watery movements from the bowels. She continued to do well, and on the ninth day the sutures were removed, and the wound was found to be healed. Another dressing was applied and left on for one week, when it was changed, and the patient allowed to sit up in bed. Three weeks from the day of operation she was allowed to get up and be about the ward, and five weeks from the day she entered the hospital she returned home. On October 26th I examined her, and found the wound in good condition, and the cervix freely movable. She DISCUSSION. 4.25 had increased in weight, and was feeling better than at any time during the past three years. i)uring the fourth week after the operation she com- plained of peculiar sensations in her head, and of hot flashes over her body, sensations she had never expe- rienced before. The tumor, after being washed and drained, weighed four and three-quarter pounds; it was very vascular, and, I think, contained fully three pounds of blood, which would make the weight of the growth between seven and eight pounds. A section of the tumor was sent to the Carnegie Laboratory and examined by Dr. Edmund K. Dunham, who reports as follows: Microscopical examination of the growth from the uterus reveals the structure of a myoma. The appear- ance harmonises with the history of rapid growth, in that the cells appear young and ill-developed ; but I do not think the structure warrants the diagnosis of Sar- coma. There is very little fibrous tissue present, the great bulk of the growth being apparently composed of unstriped muscular tissue. DISCUSSION. DR. H. D. INGRAHAM, of Erie county, wished to congratulate the reader of the paper on the successful issue of his case. In fact, so terrible are these cases of fibroid tumor or myoma that an operation with recovery should always be considered an abundant cause for congratulation. He had removed several fibroids by operation, and had treated a good many of them With electricity, but he had come to the conclusion that aside from stop- ping the haemorrhage, electricity did very little good, and often caused a great deal of harm, notably by causing the formation of adhesions. If a Case of fibroid tumor be amenable to operative treatment, it should be treated in that Way, and the sooner the better. The difficulties attendant "pon Such operations can hardly be exaggerated. He had seen Bantock, of London, work almost three hours over such a case, but he was rewarded by saving his patient's life. & The speaker said he had gone to Philadelphia on the way to this meet- ing, for the express purpose of seeing Dr. Baer, of that city, perform his original Operation for fibroma. The operation which he saw him do was the sixteenth according to this method, and he had already reported eleven 426 JWE W YORK STATE MEDICAL ASSOCIATION. recoveries out of his first twelve operations, the death in the one fatal case being due to shock. Dr. Baer places the patient in the Trendelenburg position, and brings the tumor outside of the abdominal cavity, and pass- ing a curved needle close to the uterus, ligates the broad ligament. (Method of ligation illustrated.) He then dissects down to the cervix and amputates it, and after pulling the peritonaeum over it, and perhaps taking a stitch or two in the peritonaeum, he drops the cervix back into the pel- vis. In the case referred to, not a teaspoonful of blood was lost from the neck of the uterus. Seven or eight hours after the operation his patient. was in excellent condition. The speaker thought this was the best opera- tion of the kind which had yet been devised. DR. JoHN CRONYN, of Erie county, said that in connection with the use of electricity in gynaecology he wished to refer to a case which had come under his observation, in which electricity had led to a fatal termina- tion. The patient had a fungous growth involving about two-thirds of the right side of the uterus, which he advised her not to have removed. She consulted a gynaecologist who, after puncturing the growth with a trocar and examining the contents of the tumor, expressed his willingness to operate if the patient would take the risk. This she declined to do. Although the speaker had cautioned her against submitting to electrical treatment, she went to a gentleman in Buffalo who is fond of using elec- tricity, and allowed him to treat her by electro-puncture, with the result that the tumor rapidly increased in size until it finally ruptured and caused her death three hours after the last electrical treatment. The post-mortem examination showed the abdomen filled with clotted blood, and an enormous. cauliflower growth protruding from the fundus uteri. Recent literature seemed to him to clearly establish the fact that although electricity may be useful in some departments of medicine, it has no place in gynaecology. DR. F. W. Ross, of Chemung county, said that the case just narrated was evidently not a proper one for electrical treatment, but that was no reason for condemning the whole method of treatment. In that case the electricity was, without doubt, improperly applied. All that Apostoli and his followers claim to do is to arrest haemorrhage, reduce the size Of the tumor in many cases, and in general to relieve the symptoms. Personally, he preferred giving the patient the benefit of a trial of electricity before attempting the removal of a large tumor by operation. DR. J. G. TRUAx, of New York county, commended the filling of the abdominal cavity, after the operation, with warm Thiersch's solution, and called attention to the fact that it was so quickly absorbed that there W88. good reason for believing that it lessened shock and favored recovery. He advised irrigating the abdominal cavity with this solution, or with Warm sterilised water, in every case of this kind. ExTRACTION OF STEEL FROM THE INTERIOR OF THE EYE WITH THE EIECTRO-MAGNET. By ALVIN A. HUBBELL, M.D., of Erie County. November 15, 1892. The use of the magnet in removing steel from the eye has been suggested and practiced at various times in the past, but the merit of effectually introducing it and stimulating the profession to examine into its utility, is due, first, to Dr. W. A. McKeown, 1 of Belfast, Ireland, who, in 1874, published his experience with the per- manent magnet, constructed with a tapering point; and to Dr. J. Hirschberg,” of Berlin, who, in 1881, published the results of his experiences with the electro-magnet as most ingeniously adapted to the eye by himself. Since then, various forms of both permanent and electro-mag- nets have been constructed, and every good ophthalmic Surgeon makes one of these instruments an especial part of his armamentarium. The permanent magnet, how- ever, has so little power of attracting iron as compared with the electro-magnet, that the latter has quite superseded the former. Hirschberg's electro-magnet is, perhaps, the form most used at the present time; yet, of all with Which I am acquainted, this is the most cumbersome and unwieldy. It was upon the failure of a Hirschberg magnet in the hands of a friend to serve the purposes desired, together with peculiar circumstances pressing upon me, and a de- * to save a patient’s only eye, that I was led, in 1884, * devise an instrument that seemed to me to be more in *ord with the needs of the case then put into my hands. I submitted the plan for an electro-magnet to a practical * British Medical Journal, vol. I., 1874. * Archives of Ophthalmology, vol. X., 1881. 428 NEW YORK STATE MEDICAL ASSOCIATION. electrician of my city, who made for me the One hereto- fore published in the Buffalo Medical and Surgical Journal for July, 1888. George Tiemann & Co., of New York, have, at my suggestion, recently made Some im- provements in its construction, preserving at the same time the essential features which distinguished the Original. In its new form the core is solid, soft iron, instead of a bundle of wires, and the connecting-posts are enclosed in a hard-rubber mould, which carries a slide by which the electric circuit may be closed when the magnet is being used, and opened when it is not in use. The insu- lated wire surrounds the core in eight layers, and this coil is encased by a light, hard-rubber jacket. Some of the extension-points have been Squared or flattened at their ends, by which more surface of contact is presented, and their holding power increased. The accompanying cut gives an excellent representation of the magnet and extension-points in actual size, as now manufactured by George Tiemann & Co. ELECTRO MAGNET, ACTUAL SIZE. A, A, ends of cords connecting the magnet with a galvanic battery; B, slide.” opening and closing electric circuit; C, end of core tapped to receive the extenSiOD- points. The extension-points, a few of which are shown, may be of any desired length, shape, curve or size. The instrument is 3% inches in length, including the connecting posts, the body being 2% inches long. It is a little less than 3% inch in diameter, and it weighs 3% ounces. In power of attraction it seems equal EXTRACTION OF STEEL FROM THE EYE. 429 to that of the original one which, when connected with an ordinary, single, quart-cell battery, was found by careful tests to suspend 31 ounces of iron with an extension-point % inch long (measuring from the face of the mag- net) and º, inch in diameter at its end; 28 ounces, with one V4 inch long and ſº, inch in diameter; 24 ounces, with one the same length and # inch in diameter; and 18 ounces, with one the same length and ſº, inch in diameter. The power of attraction diminishes very rapidly as the size of the point is lessened, or its length increased. Therefore, in using the magnet, as short and large an extension-point should be selected as is consistent with the case in hand. The length need never exceed 34 inch. The points may be curved or straight and of any shape desired. The electric circuit should always be opened by pushing the slide toward the end receiving the connecting-wires, when the magnet is not being used, as the current heats the wire of the coil if allowed to pass too long. The magnet can be used with any galvanic battery, by not turning on too strong a current ; but the manufacturers supply a cell suitable for the instrument. The advantages claimed for this magnet are : Its great power of attraction, its lightness, its small size, and its shape, most convenient for manipulation. With this instrument I have extracted steel from the interior of the eye in the following cases: CASE I. Michael S., forty-three years of age; boiler-maker, was struck in his left eye, June 18, 1884. The sight, he says, was destroyed at once, and an ophthalmic surgeon enucleated the ball. On the morning of August 27 following, two months after the accident to the left eye, while striking a “set,” a chip of steel flew into the right eye. The eye “watered” some afterwards, but there was very little pain, and the vision was “pretty good.” Attempts were made on the 28th by a fellow-practitioner, to extract the steel through the wound produced by it by means of a Hirschberg magnet, but without success. The doctor declined to make further efforts to get the foreign body, and the patient Was placed in my hands on the evening of August 30. The eye at this time was in constant pain with a “pricking” sensation in its upper part. Vision was reduced to counting fingers. There was considerable lachry- mation, the lids were somewhat swelled, the eye-ball was very red, and the Conjunctiva of the lower part was chemotic. There was a wound two to three millimeters long at the junction of the lower part of the cornea and selera, This was still open, and a bead of vitreous was pressing through it. The pupil was irregular in shape, a piece of iris evidently having been * off in the direction of the wound. The ophthalmoscope showed the * Cases I. and II. have already been published in the Buffalo Medical *d Surgical Journal, July, 1888. 430 NEW YORK STATE MEDIOAL ASSOCIATION. fundus to be greatly obscured by haemorrhage or inflammatory products in the vitreous, and the steel could not be seen. I was assured, however, that it had been seen in the vitreous. The lens appeared to be perfectly transparent, the wound and field of previous operations having been through the suspensory ligament. The case did not present a very hopeful prospect, but as this was the only eye left to him, I was willing to add my efforts to those that had already been made to extract the steel, and, if possible, save at least a little vision. The first thing needful, however, was a good electro-magnet, and this I did not possess, and my only means of obtaining one within a brief time was to have one made. I at once applied to an electrician of my city and suggested to him how one, in my opinion, should be made. At 10 o'clock the next day he had one ready. At 11 o'clock A.M., August 31, just four days after the injury, I pro- ceeded with the proposed operation. The patient being anaesthetised, I dissected back a small triangular flap of conjunctiva from the sclera between the equator of the ball and the ciliary region, and between the external and inferior recti muscles. After the haemorrhage was stopped, I made an antero-posterior incision about three millimeters long, through the sclera into the vitreous. A few drops of straw-colored fluid escaped. Through this incision I introduced into the vitreous an extension-point of the electro- magnet, about one centimeter in length and one millimeter in diameter at its end. I directed the point at first towards the centre of the ball and pos- teriorly, but found nothing. I then directed it forwards, when I both felt and heard a distinct click, which was also heard by the bystanders. On withdrawing the point the steel came with it, firmly held in its magnetic grasp. It was a thin scale about three millimeters in length and one and a half in width. The conjunctival flap was replaced over the incision and sutured at its apex. Very little reaction followed the operation, and both the original and operative wounds healed kindly. After several months the opacities had cleared up in the vitreous, and the patient was able to read No 2 Jaeger at fourteen inches with the aid of + 1.00 D glass. The visual field was considerably contracted—most, however, on the inner side. The ophthalmoscope showed marked choroidal changes, such as are found after choroiditis, and these were numerous, but most marked in the lower and outer parts of the fundus. The patient reads a gread deal and is enabled to earn an independent livelihood. CASE II. April 5, 1888, I was invited by Dr. Frank W. Abbott, of Buffalo, to assist him in the following case: On April 3, Miss A., about twenty years of age, was stitching leather with a sewing machine, when the needle broke and a piece struck her right eye. She applied to Dr. Abbott for advice, not, however, suffering much distress or pain. On examination there was scarcely any evidence of injury, except that the anterior chamber was obscured with blood. A solution of atropia was instilled, and She W* asked to return in two days. At this time I was invited to see the C* ExTRACTION OF STEEL FROM THE EYE. 431 The blood had become absorbed, and the pupil was nearly at its maximum dilatation, thus permitting an easy examination of the fundus. The Oph- thalmoscope showed all the media to be transparent. A piece of the sewing-machine needle could be distinctly seen in the vitreous, projecting from the anterior and inner part of the cavity directly towards its centre. A slight mark could be distinguished externally at the inner cornea-scleral junction, indicating the point of its entrance. It had evidently passed through the iris, and nearly through the ciliary body by which it was now firmly held. The eye was slightly red and irritable. Arrangements were made for an operation on April 6, at which I assisted with my electro-magnet. The patient being anaesthetised, Dr. Abbott excised a piece of conjunctiva immediately posterior to the point of entrance of the needle on the inner side of the ball over the ciliary region The haemorrhage was stopped, first using pieces of ice, but afterwards cotton steeped in hot water, which was much more effective. He then made an antero-posterior incision about three miliimeters long, directly down to the steel, through the sclera and ciliary body into the vitreous cavity. The magnet being in readiness, I introduced a small extension through the incision, and it at once grasped the broken needle, but without loosening it. I held it steadily with the magnet while the doctor enlarged the incision anteriorly until it was entirely disentangled, when it was easily withdrawn, adherent to the magnet. The conjunctival wound was closed by two sutures passed perpendic ularly to the sclerotic incision. The patient was kept quietly in bed a few days with the eye bandaged, and atropia was occasionally instilled. I examined the eye four weeks after the operation, and it appeared to have fully recovered, and vision was, the patient said, “as good as ever.” CASE III. Patrick H. E.,, twenty-eight years of age, boiler-maker, While caulking a boiler, using a hammer and caulking tool, on August 6, 1888, was struck by a scale of iron on the outer part of the cornea of the left eye. He visited an oculist of Buffalo, who examined his eye and told him that there was steel in it. He prescribed for him a two-grain solution of atropia, to be instilled every two hours, and directed him to call in two days. The patient then went to his family physician, who advised him not to Wait so long, and sent him to me. I found a vertical wound in the left 99Thea, One millimeter to the inside of the outer margin and two milimeters long. The iris beneath also had a vertical wound a little shorter and slightly gaping. No foreign body could be seen by an external examina- tion, and with the ophthalmoscope the fundus appeared clear posteriorly; but to its outer side there was a dark, opaque spot behind the region where *iris was wounded. The vision was normal. There was no pain in the *.*, but there was some lachrymation, and the eyeball was reddened. I diagnosed Steel in the eye and proceeded to find and remove it, if possible, With the electro-magnet. I used a small extension-point a little less than * “entimeter in length. After thoroughly cocainising the eye I intro- duced this through the wound of the cornea and iris produced by the 432 MEW YORK STATE MEDICAL ASSOCIATION. foreign body, carefully avoiding the crystalline lens. I passed the point to the depth of about one-half centimeter, when the iron struck it with a distinct click, which was heard by all present. It was firmly held by the magnet, and was drawn out through the wound by a little effort and after enlarging the wound slightly with a knife, the edges of the steel being ragged and catching On the surrounding tissues. The magnet was aided by forceps in the extraction, after the steel was brought to the wound. The steel was a thin scale seven millimeters long and two millimeters wide at its widest part, and weighed one grain. The crystalline lens did not seem to have been wounded either by the passing in of the steel or its removal. The eye was dressed with one to four thousand bichloride solu- tion, and a four-grain solution of atropia ordered to be used every two hours. The eye was considerably inflamed for two days after the opera- tion, but from that time on recovered rapidly, and on September 29 it was well. There was a slight scar of the cornea, and the iris showed a vertical slit at the point of injury. The crystalline lens was dotted with opacities. The vision equaled No. 60 Snellen at four meters, and Jaeger No. 18 slowly at ten inches. The patient was not seen afterwards. In this case the eye was saved, but a traumatic cataract followed which, if successfully removed later, would undoubtedly have given good vision. CASE IV. George C., twenty-nine years of age, blackSmith, consulted me on the evening of August 6, 1890, for an injury of his eye. That after- noon while cutting a bolt with a “cold chisel” a piece of the steel flew off and struck his left eye. I found a vertical wound about four millimeters long just outside of the inner cornea-scleral junction, and the iris was pro- truding through it. The anterior chamber was filled with blood, and the fundus of the eye could not be seen with the ophthalmoscope. No foreign body could be seen upon external examination, but I was of the opinion that a piece of iron had entered the vitreous space. Under cocaine anaesthesia I cut off the protruding iris, and with the electro-magnet armed with an extension-point one centimeter in length and one and one-half millimeters in diameter at its end, I began my search. On introducing the point to a depth of about one-half centimeter it caught the iron with a pronounced click, and on being withdrawn brought it to the corneal wound. I found it to be a large piece of irregular and ragged contour, and it became neces- sary to enlarge the wound a little and assist with forceps before it could be drawn out. The conjunctiva was drawn together over the sclerotic wound by a suture. After instilling a six-grain solution of atropia, the eye was dressed with 1 to 4,000 bichloride solution, and both eyes Were band- aged. The piece of steel was one centimeter long, one-half centimeter wide, and two millimeters in thickness, and weighed seven grains. Some inflammatory reaction followed the operation, but this soon subsided. The pupil was kept dilated by atropia, and the suture was removed on the fourth day. The patient was discharged September 29, with vision equaling No. 24 Snellen at three meters. At this time the media were all clear, but tº fundus showed several spots of choroidal atrophy at its inner side. FXTRACTION OF STEEL FROM THE EYE. 433 CASE W. Michael B., thirty-nine years of age, laborer, consulted me December 13, 1890. Two days previously a piece of steel from a hammer struck his right eye. The eye pained him for a short time, but had since been easy, and at this time was only slightly red. Vision equaled No. 60 Snellen at one meter. The anterior chamber was normal ; pupil normal in size and responded well to light. At the Outer part of the cornea, One millimeter inside of its margin, there was a vertical cut one millimeter in length, nearly healed. The iris showed a minute vertical opening at its outer side, half way between its pupillary margin and periphery, the bot- tom of which appeared whitish. The pupil dilated readily under cocaine, and the ophthalmoscope showed the lens to be slightly hazy at its posterior part, and at its outer and anterior portion was a milky-looking reflection one millimeter wide, starting from the iris-wound and running backwards about four millimeters. Instillations of atropia and boracic acid Solution were used every four hours. December 14, 9 A. M., consultation was held with Dr. Abbott, who agreed with me that there was steel in the eye. Under cocaine I made a vertical incision of the cornea near its outer margin and Over the iris-wound, and introduced through this and the opening in the iris, electro-magnet points of different sizes and lengths, but could not find the steel, although they were passed as deeply into the vitreous as seemed prudent. The eye was then dressed, and atropia and boracic acid solution ordered as before. December 16, the eye was painful and much inflamed. Gave the patient chloroform and made another attempt to find the steel with the magnet, and succeeded, introducing the point through the same wound as before. The steel was very minute in size, being a thin scale, two milli- meters in length and half a millimeter in width. Inflammation, which had already begun, continued, and resulted in panopthalmitis, necessitating enucleation of the ball at the end of four weeks. CASE WI. Fred T., thirty nine years of age, laborer, visited me De- Cember 5, 1891. He stated that the day before, while cutting off a rivet from a salt evaporating-pan with a chisel, he was struck in the right eye by a piece of iron. Upon examination of the eye I found it in- flamed, with a wound in the ciliary region near the outer border of the Cornea, extending obliquely downwards and inwards, and about six milli- meters in length. The iris was protruding between the lips of the wound, and both the aqueous and vitreous chambers were filled with blood. Vision °qualed no perception of light. Under cocaine the iris-protrusion was * off. An exploration was then made with the electro-magnet, using an extension-point one centimeter long and two millimeters in diameters at its end. On passing the magnet about three millimeters into the vitreous and directing it backwards, some stagnant blood flowed out and the iron was ºracted to the magnet with a pronounced click, as is usual in such cases. The piece of iron seemed to lie across the wound, and it was worked down and back With a silver probe, and after a little came out end-wise without *ging the wound. I instilled a four-grain solution of atropia, and dressed the eye With 1 to 4,000 bichloride solution. 28 434 NEW YORK STATE MEDICAL ASSOCIATION. The iron was a thick scale twelve millimeters long by four wide, and weighed three grains. Considerable inflammation followed, the conjunc- tiva becoming chemotic and the eyelids swelled. This subsided, however, in a few days, when he returned to his home fifty miles distant, after which I lost sight of him. CASE WII. William M., twenty-two years of age, boiler-maker, called at my office November 30, 1891, and stated that he had been struck in the left eye about an hour previously with something while caulking a boiler with a hammer and caulking tool. I found some blood in the lower part of the anterior chamber, and there was a cut through the sclera just below and to the inner side of the cornea, extending horizontally inwards and about three millimeters in length. No foreign body could be seen by external examination. The pupil was dilated under atropia, but the ophthalmoscope showed the fundus to be clouded with blood. The patient bad no pain. Vision equaled No. 5 Snellen at two meters. My diagnosis was steel in the vitreous humor. Under cocaine I intro- duced a point of the electro-magnet through the wound, and at a depth 40f not more than three millimeters caught a piece of iron and drew it out by a little coaxing, without the aid of any other instrument. The con- junctiva was drawn together over the sclerotic wound, a solution of atropia was instilled into the eye, and a bichloride dressing applied. The steel was a thin scale about seven millimeters long, one and one- half wide, and weighed one-half grain. The eye recovered without any inflammatory reaction, and at a subsequent examination the vision was found to be No. 5 Snellen at five meters. CASE VIII. Arthur S., twenty-four years of age, machinist, on Janu- ary 14, 1892, while holding a mandrel for another man to strike with a sledge-hammer, a piece of something flew and struck his right eye. He consulted me about four hours after the injury, and I found a clean-cut, vertical wound at the outer margin of the cornea in the Sclera. It was about three millimeters long, and the periphery of the iris was drawn into it, giving the pupil an irregular shape and a displaced position. With a probe, gently used, the iris and pupil were restored to their proper position, when an opening was detected through the iris and suspensory ligament of the lens. The eyeball was red, but the patient complained of very little pain. I could not see the bottom of the fundus with the oplithal- moscope on account of the blood in the vitreous. Vision equaled No. 9 Snellen at one meter. My diagnosis was a piece of iron in the vitreous humor, but on several careful trials with various sized points of the electro-magnet introduced through the wound, I could not find any. Failing in these efforts, I in- stilled a six-grain solution of atropia and applied bandages, with directions to call again the next day. e January 15, 10 A.M.–The eye had been comfortable since last visit, Vision equaled No. 9 Snellen at one and one-half meters. The pupil was dilated, and with the ophthalmoscope I could see at the upper and back I, XTRACTION OF STEED FROM THE EYE. 435 part of the fundus to the right side a black opacity appearing to be about six millimeters in diameter, making positive the diagnosis of steel in the vitreous chamber. The corneal wound had closed and the aqueous humor had re-formed. Atropia was again instilled and the eye bandaged. January 16, the eye was more inflamed. Vision equaled No. 24 Snellen at one meter. Dr. Abbott was called in consultation and agreed with me as to the diagnosis and that another attempt at extraction should be made. After cocainising the eye thoroughly a small conjunctival flap was raised from the sclera on the Outer side of the ball, between the external and in- ferior recti muscles. After the haemorrhage was stopped, a borizontal incision about four millimeters long was made through the Sclera into the vitreous. Through this I introduced a somewhat curved extension-point of the electro magnet, having a length of about one centimeter, and a diameter at its end of one and one-half millimeters. At a depth of about five millimeters the magnet caught the piece of iron, and it was easily brought out. It was a thin scale two millimeters long and one and one- half wide, and weighed about one-fourth of a grain. The conjunctival flap was replaced with a suture at its apex, atropia was instilled, and the eye bandaged. January 17, 11 A. M. He had very little pain during the past twenty- four hours. Pupil was well dilated and vision equaled No. 9 Snellen at two meters. The eye afterwards healed well, but on March 22, vision was lowered to a few of No. 12 Snellen at two meters. The media were trans- parent. CASE IX. John S., twenty years of age, a boiler-maker, consulted me February 21, 1892, with a history that two hours before, while driving a Steel plug into a boiler, a piece of iron struck the left eye. There was a Small wound through the lower lid below the central part of its margin, and one through the sclera a little to the left of the lower margin of the Cornea. Beneath this a small, shiny spot could be seen in the iris. A fine probe showed that the wound extended into the vitreous at this point. Vision equaled No. 36 Snellen at one meter. Under cocaine the electro- magnet was applied, introducing a small point one centimeter long through the original wound, which had been slightly enlarged with a knife. At the depth of about three millimeters the magnet caught the piece of steel, and *fter several attempts it was drawn out. Atropia was instilled and the eye Was dressed antiseptically. The steel was a thin scale about one and one-half millimeters Square. The eye made a rapid recovery, and on May 29, with —3.00 D, vision *qualed No. 18 Snellen at five meters, and the media were transparent. CASE X. William T. G., thirty years of age, a machinist, was brought to me by Dr. A. G. Bennett for consultation August 8, 1892. Sia weeks before he was struck in the left eye with a piece of steel. Vision was *Paired at once. The patient had a druggist look at his eye, but no foreign . °ould be seen. He gave him some “eye water,” which he used and **W* Šave no pain or trouble; but, as the vision did not improve, he ap- Plied to Dr. Bennett a few days ago, who examined him and made a diag- 436 NEW YORK STATE MEDICAL ASSOCIATION. nosis which I consider most commendatory to his judgment and skill as a young practitioner. My own examination simply confirmed his diagnosis. IExternally, the eye appeared perfectly normal, except that a minute hole could be seen in the iris at its inner part near its periphery. The pupil being dilated with a mydriatic, the ophthalmoscope showed a few minute opaque dots in the lens as if ‘‘peppered ” in half a dozen places, but other- wise the media were transparent. Every part of the fundus was normal, except at the macular region. Here, extending from the macula lutea directly upwards was a black line, in length a little less than the diameter of the optic disc, and in width a little more than the diameter of the largest retinal vein. It showed a slight lustre and on each side was seen a white line, evidently the sclera, exposed through the split choroid. Around this was a line of pigment. Peripheral vision was apparently normal, but central vision and that part of the field a little below the centre was lost. At a distance of five meters the central scotoma was about the size of a man's head. I did not take a perimetric chart of the field. By looking a little eccentrally, vision equaled No. 60 Snellen at five meters. There was no doubt in my mind as to the correctness of Dr. Bennett's diagnosis of steel in the retina at the upper part of the macula lutea. What should be done 7 It was agreed that the eye would be better off with the steel out, that very little danger would attend a careful attempt at extraction, and that if the effort was unsuccessful, the eye would not suffer more in the end. The eye, therefore, was thoroughly anaesthetised with cocaine and the proposed operation begun. A triangular conjunctival flap having been raised from the sclera in front of the equator, and between the external and inferior recti muscles, haemorrhage stopped, and a horizontal incision five millimeters long carried by Dr. Bennett through the bared sclera into the vitreous, I placed the patient in a convenient position in which I could use both the ophthalmoscope and the electro-magnet. I used an extension- point one and one-half centimeters long, with end one millimeter in diam- eter, and curved so as to be directed easily towards the macula. With my right hand I introduced this point through the sclerotic incision, and under the clear observation of the fundus with the ophthalmoscope held in my left hand, cautiously passed it through the vitreous to the macular region, lightly touched the black object, and then withdrew the magnet with the offending body on its point. The single attempt secured the coveted trophy. The conjunctival flap was replaced and held by a suture at its apex, atropia instilled, and the eye bandaged. No reaction followed the Opera- tion, and the eye rapidly recovered. The steel extracted was a minute scale, one and one-half millimeters long and three-fourths of a millimeter wide. October 23, 1892.—Eleven weeks after the operation the eye appeared to be normal on external examination, and with the ophthalmOSCOP9, the pupil being dilated with a mydriatic, the lens presented the same appear- ance as before the operation, the vitreous was transparent, and at the macular region at the point from which the steel had been extracted, there EXTRACTION OF STEEL FROM THE EYE. 437 was an area of about the same extent (although a little wider) as seen at the first examination, resembling in disturbance of pigment and color a patch of choroidal atrophy. Vision was the same as before the Operation, but the eye was more sensitive to light. This case, to me, is a most interesting one, and is one among a very few on record in which steel has been successfully extracted from the retina. The injury which the steel inflicted was peculiar in view of its location, and although the vision was permanently impaired by it, the operation of ex- traction did not further lessen it. REMARKS. In this group of ten cases, all that I have seen, it will be noted that in every case the steel was found in Some part of the vitreous space. In every case it had entered near the cornea-scleral junction and passed through the iris and suspensory ligament or ciliary body. In One case it passed through the lower lid first, and then through the cornea and iris into the vitreous. In eight cases it seemed to be resting in the vitreous. In One it was lodged in and held at its outer extremity by the ciliary body, and in one it was imbedded in the retina. The size of the steel varied from a minute scale to a large piece weighing seven grains. In every case but one the accident occurred while striking steel with a hammer, and the steel was propelled with great momentum. One eye was lost by infection, although antiseptic precautions Were taken in this, as in all the other cases. In three cases the first attempt at extraction failed. In one of these a Second attempt through the original wound, and in two through a sclerotic incision, was successful. In the first of these the eye became infected and was afterwards enucleated. The other two recovered with useful vision. In seven cases the steel was extracted through the original Wound on the first attempt. In one the first attempt was by an incision through the sclera and was successful. These Cases only add further and impressive illustra- tions to those furnished by other ophthalmic practitioners of the benefits of the electro-magnet in the class of in- Jºries under consideration. The lesson is that with it in a 8*at majority of the cases in which iron has been driven 438 WETW YORK STATE MEDICAL ASSOCIATION. into the cavities of the eye, this can be saved with more or less vision ; while without it almost every one would be totally lost, and perhaps cause, also, the loss of its fellow eye. In some cases the injury to an eye is so great that no attempt should be made to save it by removing the steel, but it should be enucleated or eviscerated at Once. - In considering the propriety or need of using the electro-magnet, a correct diagnosis is always desirable, but this is often not easily arrived at. The history of the case that in hammering or working iron a splinter has struck the eye, that it has made a wound through its coats, and that the piece was not afterwards found by the patient, makes the presumption very strong that it has entered the eye. As a rule, a minute object striking the eye with sufficient force to cut through its coats is carried on into the non-resisting fluids within by its own momentum. The examination of the eye by oblique illumination and the ophthalmoscope, the pupil being dilated, if possible, sometimes gives negative and sometimes positive information. Steel may be lodged at any point in the cornea, Sclera, iris, or lens, or in the vitreous or inner coats of the eye. Blood and inflammatory exudates and opacities of the cornea or lens obscure the view. But when there is no obscuration, steel is easily recognised by its black appearance, or by its shining lustre from the reflection of the light from the ophthalmoscope or focal illumination. This lustrous reflection often replaces the dark appear- ance of the iron. If the iron is in the vitreous cavity, it will appear, when seen with the ophthalmoscope, Very much magnified in size. The sensations of the patient or the state of vision are of very little value in making out a diagnosis. The diagnosis is positive when the foreign body can be seen ; when it cannot be seen it is probable in different degrees of certainty according to the history of the injury and the character of the wound inflicted. EXTRACTION OF STEEL FROM THE EYE. 439 In using the electro-magnet in a case in which steel has either probably or positively entered the eyeball, it should be made to pass as directly as possible to the supposed or known location of it in lines of least resist- ance, and through an area of least functional value. Sometimes the accident-wound meets these requirements, but oftentimes it does not. If steel has penetrated into the vitreous through the cornea near its margin, and through the iris and suspensory ligament of the lens, there is always great danger of adding further trauma- tism to the parts, and especially to the lens. That part of the ball through which the magnet can be introduced with least danger to important structures and to sight, and at the same time most accessible to every point within the vitreous chamber, is the sclera just in front of the equator of the ball, and preferably in most cases on the outer side between the external and inferior recti muscles. It is better to make the sclerotic incision after dissecting up at the place chosen a small triangular flap of conjunctiva, or excising a piece and stopping the haemorrhage. Had I selected this position for operative procedure in Case W., instead of endeavoring to follow the track of the steel, I have no doubt that I would have found and removed it on the first attempt, and saved the eye. In Cases I. and VIII. the effort to extract the steel through the cornea and iris-wound failed after several trials. But on opening the sclera, as described above, the first introduction of the magnet secured and brought it out. Case X. shows, also, how the magnet-points may be passed directly to the macular region (and, indeed, to any other) with the minimum of operative traumatism to the eye. It is also a forcible illustration of the greater ease and Safety with which a piece of steel imbedded in the coats of the eye posteriorly can be reached, than by *9te extended operative procedures. The early use of the electro-magnet is preferable to Wºlting till pathological processes follow the introduc- 440 NEW YORK STATE MEDICAL ASSOCIATION. tion of the steel. Sometimes, it is true, the eye will tolerate steel for an indefinite period of time, perhaps for years, but this is the exception rather than the rule. By waiting, the steel becomes imbedded in exudates, when the magnet cannot attract it at all, and if the eye does become inflamed, enucleation is then the only safe treat- ment. The proper use of the magnet is usually so suc- cessful when applied early, that it seems to me there is no alternative between immediate operation and delay. The form of electro-magnet, especially of the extension points, is a matter of no little importance. The magnet itself shonld be as light as possible consistent with sufficient attracting power, and of a shape convenieut for handling. The extension points should be as near as practicable to the coil around the core, and no longer than is necessary to reach the supposed location of the steel, and certainly never more than two centi- metres (three-quarters of an inch), and at the ends from one-half to one and one-half millimeters in diameter. The power of attraction diminishes very rapidly as the end is lessened in size or carried further from the coil around the core. Again, the points should not be rounded, but flat at the ends, and also on the sides from the ends backwards for a short distance, as by this a larger surface of contact is presented and the holding power increased. The magnet which has served me so well is constructed upon these principles. In conclusion, I submit this report to emphasise anew the utility and benefits of the electro-magnet in ophthal- mic surgery; to recommend its early employment ; to call attention to a special form of instrument which, I believe, better than some others, fulfills the require- ments needed; and, in addition, to advocate a more general adoption of the sclerotic incision as the safest method of reaching steel when it lies at any point, Sup- posed or known, in the vitreous humor, or the inner coats of the eye, even to the disregard of the original wound in many cases. THE MENTAL SYMPTOMS OF FATIGUE. By EDWARD CowLEs, M.D., of Somerville, Mass. November 16, 1892. The subject of mental symptoms carries with it the suggestion of something vague and difficult of appre- hension. The study of mental disorders is forbidding to the general physician who feels that he has neither time nor patience for it. The present purpose is to contribute something to a better understanding and an easier ap- preciation of the mental symptoms of fatigue, which will be considered under the following heads: (1) the nature of mental symptoms; (2) the physical conditions of fatigue; (3) Some elementary facts of the nervous and mental mechanism ; and (4) the alterations of mental functions that are significant as symptoms. 1. THE NATURE OF MENTAL SYMPTOMS. It has been the fashion to regard this branch of neu- rology as being slow in its progress, having no coherent principles, resting upon an indeterminate basis, and as being unscientific in its classification and therapeutics. Krafft-Ebing admits that the anatomy of the nervous System has so far been incomplete and unsatisfactory in not enabling us to reason from structure to function, as has been done in the relatively simple structure of the vegetative Organs; and that pathology has been disap- Pointing in failing to explain the most marked disturb- *nces of function. But he points to the fact that Psychiatry is one of the youngest of our special sci- *S. He says it seems almost exclusively dependent 442 NEW YORK STATE MEDICAL ASSOCIATION. on itself, and is limited to the direct observation of mor bid mental phenomena; also that it is from the empirical valuation of these phenomena that we are obliged to draw conclusions as to the kind and degree of the func- tional disturbance in the organ of mind. His conclusion is that great progress has been made in the raising of psychiatry to the rank of a natural science with methods. of empirical research. Its direct advancement can be accomplished only by tireless observation and report of clinical phenomena, and thus fixing the facts of the mental life. While mental disease is always brain dis- ease, the course of the processes in mental disorders is discovered through observation, as in any other disease. The hope of gaining a clearer appreciation of mental symptoms lies in the fact that we may observe so much more directly the manifestations of mind, and conse- quently of nervous function, than we can those of any other function of the nervous system. We may study, by the aid of anatomy, physiology, pathology, and physics, an involuntary mechanism like the heart ; or the action of the muscular system as a voluntary mech- anism. In the action of the peripheral apparatus we note the expression of the setting free of central nervous energy, and can trace the conducting path of the motive energy back to motor centres. But we can get no further than to speak of “innervation ” and “inhibition ” with entire ignorance of the way in which nervous substance is stimulated, and augments or controls that which stimulates it into activity. We are conscious that the mode of expression of the active mind through the peri- pheral instruments is indirect. All this is true also of the complex organ of speech, when examined as an organ, and as one of the minor mechanisms of whose anatomy and pathology we may make the most scientific study, as we need to do for a correct interpretation of any change from normal action. But through this organ we hear in the articulate sounds with varied tone, pitch, and inflection, and in the words THE MENTAL SYMPTOMS OF FA TIG UE. 443 which this instrument produces, the direct expression of a function by which brain cells are able to convey to our understanding the largeness and fineness of meaning that is comprehended in the “infinite variety” of the buman mind. This takes us into a field of phenomena that our kindred sciences fail to reach. Instead of lamenting that they do not aid us, it is perhaps more true to say that we do not need their aid in the interpre- tation of these manifestations, which, by a superior mode of expression, convey finer variations of meaning, and make revelations of earlier and slighter departures from normal action than we can get from any other function of the human organism. Moreover, it is given us to make these discriminations, by the natural law of mind, without any need of laborious study and interpretation of the working of an intervening instrument. We hear the expression of thought and feeling in sounds that we come to know, and we need not stop to note the mech- anism of their utterance. From the moment when we are thrust into this noisy world, the articulate sounds of the human voice begin to be familiar to us. Every man makes his way in the world largely by his success in measuring the minds of his fellow-men. We have, by nature, a most intimate common knowledge of variations in mental function; of no science have we a more prac- tical every-day knowledge than of psychology. It is true that we have to discover a way to reduce the data of this knowledge to orderly form, and to recognise the import of commonly observed mental manifestations by observing their correspondence with recognised bodily °onditions. This must constitute a true science of the health and disease of a function which has its own Peculiar character and physiological laws. The nature of mental symptoms, or manifestations of *partures from normal functions, being thus under. stood, we should approach their study with minds free from prejudice, prepared to observe and fix the facts of *h kind of manifestation and array them in the order 444 NETW YORK STATE MEDICAL ASSOCIATION. of their occurrence and relations with each other. The question now comes, can we set up a plain and intelli- gible conception of the normal mental mechanism that will serve as our standard in which to note and localise, as it were, the departures from normal action ? We must begin in an elementary way, and deal first with the slighter variations from conditions of health in the mechanism, and its fullness of power to do what it can do. In the brief time allotted here, the attempt will be made to do little more than to point out a method of observation and study on the basis of some of the prim- ary facts of the mental and nervous mechanism. 2. THE PHYSICAL CONDITIONS OF FATIGUE. The proposition may be laid down to start with, as a working formula, that the organ of the mind is an appar- atus for the storage and discharge of nervous energy, and that all mental symptoms indicate a failure of the mental elements to functionate with normal co-ordi- nation, because of modification of the power to set free nervous energy, due to lack of the discharging force, or the obstruction of it, or to lessened power of control; or as due to excess of stimulation and discharge, which means also relative weakness of inhibitory control. All of these conditions of nervous action may exist together, or side by side, and often do, not only in the most mani- fest of mental diseases, but in the lesser degree of ner- vous fatigue. In fact the key to the understanding of these graver conditions seems to be in the appreciation of the slighter degree of nervous exhaustion always to be observed in normal fatigue. The condition of the Cen- tral organ may be directly observed through the mental symptoms which quickly reflect the variations in nervous force and activity. The correct understanding of these symptoms is essential to the best treatment of nervous exhaustion in all its forms. And this is the soil in which the more serious nervous diseases take root and grow. THE MENTAL SYMPTOMS OF HATIG UE. 445, The bodily conditions of fatigue should first be con- sidered as far as we can know them, and may be studied in their two forms of degrees: (1) normal fatigue, or the condition of wholesome tire from daily physiological use ; and (2) pathological fatigue, or the condition of persistent “impoverishment of nervous tissue in excess of repair,” according to Beard, which constitutes nervous exhaustion or neurasthenia. The mental symptoms are to be studied to their close and direct correspondence with these conditions of fatigue. The effects of fatigue are produced by sufficiently con- tinued exercise in the physiological use of any func- tion, muscular or nervous. The sense of fatigue is com- plex, and may have a central or peripheral source, or both together. In muscular tissue the condition of fatigue depends upon the physiological fact that muscu- lar contraction is in some way or other the result of a chemical change, whereby the latent energy is set free and expended in the mechanical work, with also the setting free of heat. The resultant chemical products are toxic, and obstructive of muscular function unless. they are duly washed away in the blood current ; and time must be given in rest and sleep for this process, as Well as for nutrition and repair. These toxic products. being variously irritant or benumbing, doubtless thus. affect the sensory apparatus through which fatigue is felt. It is evident from this that the condition of mus- cular fatigue has always a dual character—there is direct expenditure of energy, requiring repair, and a toxic element that may be obstructive of function, both that of discharging energy and of taking up nutrition. In nervous substance, the nature of nerve force being unknown, the effects of the passage of a nervous impulse along nerve-fibres are not demonstrable as attended by chemical changes, or loss of normal irritability as a *anifestation of fatigue. But in the central nervous. *8ans it is found that their function is dependent on an * Bowdich, Journ. of Phys., Wol. 6, p. 133, 446 NEW YORK STATE MEDICAL ASSOCIATION. adequate supply of Oxygen, and this implies that “in nervous, as in muscular substance, a metabolism, mainly of an oxidative character, is the real cause of the develop- ment of energy.” In fact we do not doubt that toxic waste products attend upon central nervous activity, and this accords with the biological theory that all function is due to chemical changes taking place within the organism, and that the functional activity of a specialised tissue depends primarily upon the changes in its individ- dual cells. The dual character of all conditions of pri- mary fatigue is evident, as is also the importance of recognising the effects of the self-produced poisonous substances that regularly result from the chemical changes in tissue metabolism within the body, as we are taught by the brilliant revelations of modern chemical physiology and pathology. Normal fatigue from the discharge of tissue energy is therefore shown to be inseparably accompanied by toxic products that contribute to the effects of fatigue. Pathological fatigue represents a further development and persistence of this condition in the organism. Stimu- lation too soon repeated, without giving time for rest and repair, finds nerve-cells in fatigued areas having less power to act because of inanition from deficient rest and nourishment; they are also hindered in action by the incomplete removal of the toxic products of previous action. Then assimilation is further hindered, first, by the lessened nutritive quality of the blood from the presence of non-eliminated toxic materials; and Sec- ondly, by the probable toxic weakening of the cells' power to assimilate the nutrition that is furnished to them. The development of a manifestly morbid condition may be very slow and insidious, or more rapid, according as the balance of the processes of constructive and regreS- sive metabolism are more or less on the side of impover- ishment, exhaustion, and weakness. From the gradually failing elimination, the local inanition may become more 1 Foster, Physiology, 5th Eng. Ed., 1890, pp. 914–918. § THE MENTAL SYMPTOMS OF FA TIG UE. 447 general, and the first results are an increased excitability from weakened resistance and inhibition, with a quick exhaustion of the nervous system under exercise. These are the constant characteristics of neurasthenia. Thus, as Kowalewsky “says, “a locally limited over-strain of a certain part of the nervous system may lead to general exhaustion and neurasthenia.” Hence neurasthenia has been defined by Ziemssen “as “a functional weakness of the nervous system, varying from the slightest degrees in simple localities to entire loss of strength in the whole nervous system.” Arndt * states the characteristics of neurasthenia to be “increased excitability with a ten- dency to rapid fatigue, especially of the muscular sys- tem.” He notes particularly, also, the cerebral irrita- bility, and hyperaesthesia of the cranial nerves, especially those of special senses. The remarkable experiments of Hodge' are most sug gestive as demonstrating the physiological shrinkage and recovery of cell contents in spinal ganglion cells; it is shown that upon stimulation and upon normal exercise, the histological changes of breaking down and building up of cell contents are accompaniments of the physio- logical discharge and re-storage of energy, and as being normally attendant upon fatigue followed by rest. The conditions of the organism in normal and patho- logical fatigue being thus understood, we have a basis for the study of the relation thereto of the mental symp- toms of fatigue. It is agreed by all observers that the Symptoms of nervous exhaustion are mainly suggestive. The objective symptoms need not be dwelt upon here; the °ommonly noted manifestations of increased excitability, irritability and restlessness are readily recognised as *ēpresenting the internal hyperaesthesia so significant of the “irritable weakness” of nervous exhaustion. The * Centralblatt, f. Nervenheilkunde, October, 1890. Neurºshenia, Wood's Monographs, Vol. 1, 1889, p. 534. 4 * Neurasthenia, Tuke's Dict. Psych., Med., 1892, Vol.2, p. 848. 4mer. Jour. of Psychol., May, 1888; May, 1889; and February, 1891. 448 NEW YORK STATE MEDICAL ASSOCIATION. purpose now is to show the significance of a few easily, and in fact commonly, recognised subjective or mental symptoms, which stand as distinctive signs of fatigue. They furnish a ready index of the fatigue and auto- intoxication of nerve and muscle tissues as a guide for diagnosis, prophylaxis and treatment ; and the general symptoms of nervous exhaustion can be understood better and earlier by the proper interpretation of the mental symptoms. 3. SOME ELEMENTARY FACTS OF THE NERVOUS AND MIENTAL MECHANISM. In order to make clear the changes, that we call symp- toms, in the mental manifestations, it is necessary to note some elementary facts in the relations between the functions of the mind and body. While they are very complex in their detail, there are still certain broad gen- eralisations that we could readily grasp but for the difficulty of keeping a number of the elements alike prominent in our minds at the same time, while studying their inter-play. This may be aided, with some exercise of the imagination, by the tabulated diagram here pre- sented. It is designed to represent the nervous and onental mechanism, and to show some of the relations of the inner activities that we call mental, to the body in general, and to the environment. Let us suppose that we can lookinto the region of Con- scious mind as into an enclosed place, and a section being made of it we can see noted thereon, as in the “field of consciousness,” the modes of mental action as they are designated by common agreement. At the other end of the diagram are noted the organs of special sense through which stimuli from the environment start impulses that are conducted along sensory tracts, and produce physical sensations in the sensory centres in the entrance to the “field of consciousness.” When these sensations alº intense enough to pass over “the threshold of the field of § |NERVOUS AND MENTAL MECHANISM : | PH Y s ] C A L F E E 1 | N G - Co N scſo Us A N p SU B-C O N scſo Us | L-J SEnsory L-J SENSORY CENTRES <- 4— SENSORY ORGANS | | NERVES | – ; H l—tt—l l— , -1 | | | 1 t | 1 1. SEWSE PERCEPTION. ! !! | | | H ' (IDEAs) 5 | *; | | | - 2 2 ' Memony tal : ; ; r --- " ---n Lº- | (IMAGINATION ) : | | : ! GENERAL ! SPECIAL g 3. cdºcriving JUDGING º | ! ; : | “..." º ;Reasoning. -> | 1 , ! --~~~~ | || Evg * | 1 * STOMACH, Y | § | % ; +; ! HEART EAR 4. FEELINGS, EMOTions, | 1 t { 4- tº p # I | Lungs ! Nose O tº- | *—, 5 MORAL SENSE. d ; : uscles Mourº | INSTINCTS * | ! : EYC ETC Skirt ſ: t R | | | : t ETC | Erc. º | !!! *-- ºr-- P | 6. WiLLING - ; : ; : : | , anº # ; ; ; : 2 t | | ACTING. > | ! | ! g | W :*: | | | - º | |-} * L-TVEToº Tl- MOTOR CENTRES –). N — MOTOR ORGANS -> _r-l ERVEs T-I T- 3. 450 NEW YORK STATE MEDICAL ASSOCIATION. consciousness,” there is a conscious mental perception of Such sensations, as of sight, hearing, and the like. This is the initial event of the process by which we mentally see, perceive, and know, something in the environment; there is, through Sensory action, the presentation in our field of consciousness, and the perception, of what we call the image or idea of the external thing. But we may immediately remember that we have seen the same object before, and we become conscious of an action of memory, by which we retain impressions previously received, and can recall them by the law of association of ideas. We image them again, or imagine them. Thus a complex mode of mental action arises; there is consciousness, then conscious perception of a sensation, as from the Sense of sight, and memory, acting all together. Hard upon this comes the higher process of ideation or intel- lection, the comparing process, by which we conceive abstract notions of things, judge them by comparison, and reason about them. All these may be included also in the mode of consciousness along with perception and memory, and form parts of a complex process of knowing, or intellection, although we name them as separate actions. Whenever we talk with a man, we gauge and test minutely all these operations of his mind with great practical accuracy. We estimate his mental quality and power; we judge the man by what his mind can do. One of the points of present interest is now before us; as the antecedent fact in the mental process just described, we must premise the state or existence of conscious- ness, without which there can be no mental action. We may say that there is latent consciousness in an unborn infant, that soon after enters upon conscious life ; then consciousness springs into action, and the first percep- tion is likely to be of sensations from the sense of touch. But active consciousness is always attending to Some presentation in its field, to the more or less complete exclusion of other presentations. While the multitude of sensations are thronging into the sensorium through THE MENTAL SYMPTOMS OF FATIG UE. 451 all the organs of special sense, the attention, being fixed upon some intensified perception, excludes all but this intensified one. The same is true of a presentation of memory, or of a process of reasoning; or all these may be involved in a complex object of attention. When- ever, by the action of what we call the attention, we hold in mind a perception, a memory, or the data of a process of reasoning, we are exercising the memory also in the very act of retaining all these elements of the mental process. On the other hand we know that by the atten- tion we can control the memory, by controlling and changing the flow of ideas it recalls; and all this goes to show the inseparable working together of these processes. The attention is a mental element of the greatest interest, and is commonly regarded as meaning a “con- centration of consciousness.” According to Sully it may be defined as the active intensification of consciousness in particular directions. Whatever, at any time, “Occupies the mind,” is for the moment the supreme object of attention. The attention is one with active Consciousness, and is often described as accompanying eVery other mental action. It is a common experience, in revery and in dreams, that a spontaneous flow of ideas is continually passing through the mind; one item follows another in the train of associated ideas through the working of memory and imagination by the laws of habit and association, Without direction or control. The attention is then said to be acting in one of its two forms, and this form is *Pºntaneous attention. It is also called reflea attention, *s it acts by being attracted to the idea or object in the *ind that most interests it, or keeps it on the alert, or Stimulates it. The idea may be intensified in interest by pleasurable or painful feeling, by a desire or a fear. The act itself of attention to such an object of thought, *ses the intensification of it, and tends to keep * Art, Attention. Tuke's Dict. Psych, Med., Wol. 1, p. 106. 452 NEW YORK STATE MEDICAL ASSOCIATION. ideas of kindred nature in the mind ; the mind dwells upon them, is absorbed in them. Voluntary attention is the other form of this mental function ; and this is at the very centre of interest in this inquiry. It is spontaneous attention with the added power of direction and control ; the attention is thus in- separably associated with the will, volition, or control- Ting power. The essential fact is that in voluntary atten- tion lies the mental activity of inhibition ; it is inhibition working through attention. According to Foster, just as physiological inhibition plays its part in the lower mechanisms of the body, so is it important in the whole work of the central nervous system. Also, just as all voluntary muscular actions are under the control of an attending will, so is the directing and concentrating of the attention upon a chosen thought an act of volition. A man controls his own mind by willing his attention, as it were, to be fixed upon some one item or object, in the train of presented ideas, to the exclusion of others. He thinks about what he chooses to think about, and inhibits mind wandering. He may make the most worthy object interesting; this is intensified by holding in mental view its worthiness, and thus the attractions of less worthy interests and emotions are resisted. Sully says it is pre-eminently by acts of attention that all the elaborate work of thought is effected, and that the attention is the great conditioning factor in our intelled- tual life; all great intellectual achievement involves energy of will acting as voluntary attention. The student attains to this power by training and education of his higher mental control; the man who chooses the path of wisdom and rectitude exercises and strengthens his power of voluntary attention by the practice of self-con, trol in inhibiting the impulses of his passions. Thus it. is that voluntary attention is in close relation with tº highest as well as the latest developed acquirements of the mind, in its power to use the force of nervous ener8X to the best effect. It is well known that the late" THE MENTAL SYMPTOMS OF FATIGUE. 453 acquirements are soonest impaired with the abatement of normal energy. w Every exercise of the will in attention is accompanied by the expenditure of energy, and by the “sense of effort” that occurs, particularly when the attention works against Some resisting motive, interest or feeling. This directing and inhibitory control is at its best in the equi- librium of health of mind and body, and therefore it is a most important means of estimating mental health and vigor; mental disorder is commonly attended with dis- turbances of the normal process of attention, as will directly appear in the discussion of mental symptoms. This constitutes one of the points of great diagnostic value. - We have, so far, concerned ourselves in this discussion quite exclusively with the processes of knowing or intel- lection. But we are always conscious of another order of mental phenomena, the feelings, and they are of pleas- ure or of pain, or they may be in varying degrees agree- able or disagreeable. From the lower forms of bodily pleasure and pain, upward in the scale to those aroused by the perceptions of color and music, the feelings are said to be “corporeal.” But the purely mental feeling that always attends upon pleasurable or painful ideas, is inseparable from them. Without ideas there can be no such feeling; and according to its intensity, a feeling of pleasure or pain intensifies the idea it accompanies, and makes it prominent in consciousness, tending to attract *ore strongly, and to hold, the attention. Thus, as has already been shown, there may be an antagonism between Worthy and unworthy ideas and feelings, or in the moral *nse of right and wrong, with need of the inhibitory P9Wer of voluntary attention to choose, control, and guide conduct. This brings out the opposing factors in * Of will, attention, ideas, and feelings. The be i § excited by ideas prompt to action, which may ºubled or augmented by an opposing or consenting 454 NEW YORK STATE MEDICAL ASSOCIATION. Referring now to the diagrams, the relations of these activities are seen to be noted in their natural order. Feeling follows upon intellection, and all the included mental activities are operating in the field of conscious- ness. The outcome of this interplay is in the union of willing with acting at the point where the resultant of the mental forces appears to act upon the motor centres, or stimulate in them the impulses that end in the setting free of muscular motion. Thus the picture of the “nerv- ous circle” is now complete, and shows the working of the nervous and mental mechanism under the stimula- tion of sensations through the special senses. Then con- sciousness, through the attention (these two being gen- eral states, or modes of mental action), knows, or “sees” in the very mind’s eye, the special modes of action which we call sense-perception, memory, reasoning, feeling, and the willing of motor impulses which end in muscular motion. This completes the “circle.” The sensations from the special senses are those of which we are most conscious; they are of high intensity, but we little realise that they are small in volume com- pared with the great inflow of organic sensations of which, in normal conditions, we are not conscious. These organic sensations, that, according to Ribot, give us the sense of body, or of personality, are of low inten- sity but vast in volume; proceeding from every minute part of the tissues and organs of the body, their inflow, along sensory tracts, enters the sensorium beneath the “threshold of consciousness” into the region of sub- consciousness. Their origin is shown in the Sources noted in the fainter letters in the diagram, and their course by the dotted lines. The muscular sense, which is complex in its origin, includes feelings that afford an example of the more pronounced of these organic Sensa- tions. Thus, we get the sense of weight and posture. Again there are those not felt in normal conditions, but, like hunger and thirst, which are general in their origin, may become intensified so that at times there 18 THE MENTAL SYMPTOM'S OF HATIG UE. 455 consciousness of them. There are still others, as in the morbid conditions of hyperaesthesia, and paraesthesia, that appear as pain or a general feeling of misery ; they are vague in character, and their sources often can not be determined. These organic Sensations, and their alterations, are of such a nature that they afford another point in the nerv- ous and mental mechanism of great diagnostic value. In normal states, when all is well with the organism in the equilibrium of health, they constitute the sense of well- being. Here again we have an important means of meas- uring any falling off of nervous vigor; from the slighter alterations of bodily feelings in fatigue to those that Create a persistent sense of ill-being, these changes cause Variations in the emotional tone that are the most sensi- tive indices of the degree of fatigue and exhaustion, both normal and pathological. The emotional tone is thus Seen to be affected in two ways. There may be, in health, all degrees of pleasurable or painful mental feel- ing, between the extremes of exaltation and depression, according to what one has to think about ; in this case a lowered emotional tone from grief or care may be a pass- ing event, or if prolonged, may have a directly debilitat- ing effect upon the organism through the motor tract of the nervous system. The stimulant and depressant effects of the natural emotions upon the circulatory sys- tem and upon bodily health in general, are well enough known. On the other hand, a persistent state of morbid depression of feeling may be no more than the mental ConComitant of bodily ill-being, however it may have been induced. There may be three events in the train: First, undue care, real trouble, and anxiety or grief may initiate a general condition of ill-being, which, in turn, *y be the cause of morbid depression as the third *Vent. The first in this order may be entirely wanting, but the condition of precedent impairment of health and *Wous Vigor must exist from some cause, before the Strictly morbid mental Symptoms can appear. 456 NEW YORK STATE MEDICAL ASSOOIATION. 4. THE ALTERATIONS OF MENTAL FUNCTIONS THAT ARE SIGNIFICANT AS SYMPTOMS. It now remains to describe the special alterations in some of these prominent factors of the mental mechan- ism, and their significance in conditions of normal and pathological fatigue. In normal fatigue it is to be kept in mind, that the dual physical condition is one of the expenditure of nervous energy in work to the immediate fatigue of nerve cells, and the accumulation, locally and in the circulatory system, of toxic waste products; and that the processes of nutrition and elim- ination require time and rest. The mental concomitants of this condition are : A diminished Sense of well- being, or a feeling of fatigue, sometimes amounting to a sense of ill-being, which includes in its complex causa- tion the influence of the toxic elements. The emotional tone is lowered, and there is less vivacity of feeling. There is also lessened mental activity in general. Voluntary attention is fatigued; that is, the mental inhibition is lessened, with diminished control over the attention, and one is conscious of an extra sense of effort in mental work. There is “mind wandering.” The logical pro- cesses work more slowly and with less effect in making comparisons and judgments, and in reasoning to conclu- sions; the tired attention holds on with effort to One member of a proposition, while another slips away. There is a consciousness of mental inadequacy and diffi- culty in keeping awake. This is the common experience of evening tire. Testoration follows upon a due amount of rest, sleep and nutrition, and the somnolence disap- pears when the acid waste products, etc., in the circula- tion are removed. The condition of pathological fatigue is induced when the process of restoration is continuously incom- plete. Then we have to conceive of deficient nutrition and an irritating intoxication as both contributing to the “irritable weakness,” which is a manifestation of the characteristic hyperaesthesia. We may now note the THE MENTAL SYMPTOMS OF FATIGUE. 457 significant alterations of the feelings, the irritability of temper, the weakening of the power of voluntary atten- tion, and the effects of these alterations. The patient may complain of painful or miserable bodily sensations –hyperaesthesia and restlessness—and often of paraes- thesia in various forms. The symptoms may be ana- lysed and classified according to the order of their appearance, and the functions affected. The first order of mental symptoms of pathological fatigue, in the importance and earliness of their appear- ance, may now be noted. These most obvious mental signs are the characteristic depression of feeling, a low- ering of the emotional tone, and a sense of ill-being. The symptoms quickly reflect debilitated bodily con- ditions that are the sources of the “miserable feelings.” These subjective indications are often the only ones of the existing exhaustion in its complex character. Again, they are corroborative of a suspicion of general neuras- thenia when complaint is made of some local functional disorder; in other words, local disorder is often shown to be simply an expression of general neurasthenia, of which the only diagnostic evidence is in the mental symptoms. The second order of mental symptoms, in time of appearance, is usually the persistent decrease of the power of voluntary attention (reflea attention), and 80metimes of memory; there is also the sense of in- adequacy of effort. These symptoms refer to the attention, which acts in a Thore Spontaneous and reflex manner as its control is Weakened; the memory is weakened in its power of retaining and recalling ideas. This lessening of inhibi- tory power, and mental activity in general, shows the abatement of cerebral energy. It does not always appear to the observer, for the reason that the patient may draw "Pon the reserved nervous energy, and put forth more effort in the act of controlling his attention, and succeed IIl doing it. But he is both expending energy more *Pidly in so doing, and is conscious of the need of 458 WEW YORK STATE MEDICAL ASSOCIATION. increased effort ; he will usually readily confess it on being questioned. This consciousness finally amounts to the very characteristic sense of inadequacy. This symptom of weakened voluntary attention is also an early one, and is very diagnostic. The patient will often complain that he cannot keep his thoughts on his work or business, or has to read over again what he reads, and can not remember it. One patient said “I can not sense it;” and another, “I can not centre my mind on what I try to do.” A third order of symptoms may now arise, and it is an interesting fact that they grow out of the other two orders, and are their logical consequence; these are ſmorbid introspection, retrospection, and apprehension (worry and hypochondria). These symptoms, when manifestly developed, mark a graver degree of fatigue. The emotional tone being low- ered, the patient in a state of depression of feeling is prone to “look upon the dark side of things.” Ideas are intensified that are accompanied by painful feelings, which are thus in harmony with the prevailing emotional tone. There being also a lessening of nervous energy in voluntary attention, it cannot inhibit the intensified painful ideas and feelings, and there is consequently worry about the present, past, and future. The Vague fear arises of being unable to meet the requirements of the future. The increasing sense of present inability gives intensification to the characteristic sense of inade- quacy noted by Beard as being so prominent. There is one other set of symptoms to be mentioned as constituting a fourth order. While those previously noted are purely mental, these are partly so, but relate chiefly to alterations that cause peculiar bodily effects, and are often manifest to the observer. These symptoms are: changed organic sensations, physical and mental £rritability, and restlessness ; diminished sens?!?0° quess, dullness and languor. There is apparent irregularity in these changes of THE MEWTAI, SYMPTOMS OF FATIG UE. 459 bodily feelings and their manifestations—the intensify- ing of some and the lessening of others. Arndt says: “It is clear that the increased hyperaesthesia, which a degenerating nerve at first presents, can not last long, and that soon decreased excitability, bluntness, paresis, or whatever we call fatigue or exhaustion, must take its place.” - There is not alone hyperaesthesia, with the external signs of irritability and restlessness, but there is much diminished sensitiveness. Some cases are altogether of the latter character, and many present both conditions at the same time, in Some particulars. It may be a ques- tion of the different effects of variations in the toxic waste products. While chemical physiology and pathol- Ogy do not yet enable us to ascribe sensory and motor disorders definitely to the influence of poisons produced Within the organism by its own activity, it cannot be doubted that both the conditions of nervous irritability and those of dullness, languor, and stupor, may be so Caused. It is certain that such external manifestations may be caused as the direct expression of defective functional activity in cerebral centres that are the source of the nervous energy which innervates and controls both the somatic and mental mechanisms. The study of physical expression which Darwin raised to the dig- nity of a new science, shows that while there is certain Voluntary control over it, still the manifestations in the muscular movements of expression, whether occurring in the face or the extremities, have a direct automatic dependence upon interior states of the central nervous System, which are thus externally reflected. The inflow of 9 ganic sensations to the senorium has its complement * the constant, regular and subconscious transmission * nerve force from central cells to the muscular peri- P*Y. This accords with Gowers' statement that every *ture of the brain concerned with sensation proper is *cted directly or indirectly with a part concerned * Loc. cit, 460 NEW YORK STATE MEDIOAL ASSOCIATION. with motion ; and, in regard to the unstable condition of brain cells in disease, when the equilibrium between the discharge of energy and the inhibition of it is disordered, “the discharge may depend on the production of force within being increased in excess of the resistance, or on the resistance being duly lessened.” In the common forms of insanity are seen the most pronounced expressions of excessive or diminished cen- tral activity, and this applies alike to innervation and inhibition, whether mental or somatic. In the belief of the writer' it is possible to detect important variations in the several elements of mental activity in normal fatigue and nervous exhaustion. For example : the letting down of mental power in voluntary control, with the conse- Quent lessened inhibition of verbal expression of grief and worry, or excitability and aggressiveness. Bancroft” has made an instructive application of the physiological principles of expression, to the study of facial expression of the emotions in insanity and of expression in posture, etc., as the results of habit in automatic muscular action. His work gives definite value to the clinical use of photog- raphy in the physical expression of mental changes. All such clinical studies of mental symptoms demon- strate the value of precise appreciation of the changes in the elementary mental activities. It is common to observe, in mania, either excessive, uninhibited, mental and motor activity, or the quite normal control of the latter, along with the gravest deficiency of mental inhi- bition. Again, there is excessive nerve-muscular activity, or tension in fixed attitudes, in the mental and motor expression of painful emotion in melancholia, and in consequence of lessened inhibitory will power; and still again, all expression may be abolished in the real mental stupor of melancholia and mania. This abolition may *Pathological Fatigue or Neurasthenia (the Shattuck lecture, 1891, Mass. Med. Soc.) Amer. Jour. Insanity, July and Oct., 1891. *Automatic muscular movements among the insane, Amor, Jour. */ Psych., Feb., 1891, THE MENTAL SYMPTOMS OF FATIG UE. 461 also be due alone to the fact that, while perception and ideation are quite normal, the power to give expression to them is diminished or lost, either in the failure of the mental function of willing, or of excitability in the motor centres. A man at the McLean Asylum, who was apparently in profound stupor, afterwards said: “I wanted to answer you, but couldn’t make my jaws go.” A woman who would stand in a fixed position for hours with almost entire loss of muscular movement and ex- pressionless face, could respond to kind words only by directing her eyes, and they would fill with tears. When she was well, the next year, she gratefully told what had been said and done to her. The apparent stupor is often mistaken for the real condition. These discriminations of the mental processes being once established, they have the highest therapeutic value in their preventive application. Hence the thesis of this paper: the importance of an early appreciation of the mental symptoms of normal fatigue that tends to nervous exhaustion, for they are prodromic of its graver forms. Moreover, the recognition of the significance of changes in the motor and sensory manifestations, in the direction of languor as well as irritability—anaesthesia as well as hyperaesthesia—is of the first importance in the difficult task of managing convalescence from true neurasthenia. The “irritable weakness,” includes the liability to quick exhaustion of the small increments of hervous energy that have been slowly gained, and there- With the speedy reduction of sensory, as well as motor power, to the degree of “bluntness,” as Arndt has stated it. Pathological fatigue, or nervous exhaustion, being shown to be a condition in which there is direct and °onstant relation between physical disorder and mental Symptoms, these should be noted, together with both the *rease and the blunting of sensitiveness, in any compre- hensive definition of the disease. It may therefore be *fined as follows: Neurasthenia is a morbid condition of the nervous System, and its underlying characteris- 462 NEW YORK STATE MEDICAL ASSOCIATION, tics are ea cessive weakness, and irritability or languor, with mental depression and weakened attention. This method of analysis into four orders of symptoms is applicable to all cases of neurasthenic disorder of the physiological activities involved, from the passing over of normal into pathological fatigue, in the simplest forms, to the gravest manifestations of emotional dis- turbances, disordered attention, and sensory and motor irritability and languor. The symptoms included in the first three orders are regarded as purely mental ; those characterised in the fourth order, while referring to the well-marked development of changes in sensitiveness and activity of bodily functions, imply the necessary association with them of the mental symptoms before noted. These changes of bodily sense and activity may be detected, in the slighter degrees, in the earlier stages of neurasthenia. The value of the practical application of these discriminations in diagnosis may now be illus- trated by describing some of the special ways in which certain symptoms must be interpreted. By this method of analysis we may readily estimate the significance of the symptoms of depression of feeling, of weakening of voluntary attention, and of worry. But there are certain more subtle effects of the mixed condition, usually found, of hyperaesthesia and anaesthesia. One of the most striking special symptoms which the foregoing considerations point out and may serve to ex- plain, is a paradoxical one, but one most commonly pre- sented for clinical observation. The sensory function by which the complex normal feelings of fatigue are appreciated, may itself be over-exercised to exhaustion. There is tire of the power to feel the tire. This condi- tion may be called fatigue-anaesthesia, and, beginning with the early stages of pathological fatigue, there is usually some degree of it. Every physician has ex- perienced this when, after a night of anxious profes- sional work, , with loss of sleep, he has a day of excit. able alertness of mind and body, and there is a Sense of THE MENTAL SYMPTOMS OF FATIGUE. 463 nervous strain, with, perhaps, undue mental facility and physical irritability. Many hours sleep may be gained in the following night, but instead of feeling refreshed he has a sense of malaise, languor and fatigue. The real fatigue was greater the day before, but he could not feel it as such. It is not until the Second day after the excessive effort that he has recovered his exhausted power to feel the fatigue. In a lesser degree this fatigue- anaesthesia becomes a constant accompaniment of the neurasthenic condition. Over-worked women, profes- sional and business men “work on their nerves,” and say they “don’t feel tired, and nothing is the matter.” They “feel better” when actively exercised in their customary labors. This condition comes on insidiously, and is a most dangerous One. The patient is neuras- thenic before anybody suspects it. With the impair- ment of the natural fatigue-sense the mental effect is that he will not believe even his physician’s diagnosis of “fatigue.” He is, therefore, prone to look for some other reason for his sense of ill-being and inefficiency ; and finds, in retrospection, cause for Self-reproach and helplessness in the future. Fatigue-anaesthesia manifests itself in connection With another special symptom peculiar to conditions of “fatigue,” that of “morning tire,” sometimes called “morning misery.” Extreme examples of this are seen in the victims of dissipation. In ordinary cases of pathological fatigue it is a persistent symptom; the patient is likely to awake in the early morning unre- freshed by a fair amount of sleep, and often in the depths of depression. The physical signs of exhaustion are then more manifest. These symptoms represent the truth as to his neurasthenic condition. After breakfast he feels better, and by the middle of the day the stimulation of the daily interests and press of business has apparently restored his good feeling. At the close of the day he is comfortable and cheerful, laughs at his morning fears, * is prone to over-do himself in recreation or evening 464 NEW YORK STATE MEDICAL ASSOCIATION. work. That day’s experience is regularly repeated. Each night he rests enough to recover Some of the feel- ings that attend upon “fatigue,” but he often does not recognise it in the absence of the true fatigue-sense. A still further blunting of this sense is caused by the ill- timed stimulation of unwisely continued effort. Along with the restlessness of his “irritable weakness,” there is a fictitious sense of well-being because of the tempor- ary abolition of the sense of ill-being, as in mild intoxi- cation by alcohol. In the management of convalescence from neurasthenia, or of cases that would get well if they could be man- aged, there is nothing more discouraging than the succes- sion of relapses that they undergo. Such patients, having been subjected to rest treatment, may be fat enough and maintain a fair degree of comfort when effort is kept within the limits of pathological fatigue. They complain of tire and various discomforts upon a little effort, which must be made in order to gain by physiological use the strength to make it. It seems a never-ending process; Some patients cannot abide its slowness, and make effort too soon ; others resist great persuasion to make enough. But some event may occur that excites desire or a sense of duty. The undue quickness of response to the stimu- lation of interest and attention is to be recognised as an evidence of irritable weakness. The apparent ease and unwonted Zest of the effort is not a manifestation of real power; it means that there is a speedy blunting of the sense of fatigue. The reaction of exhaustion and mental misery that follows shows the real weakness and the need of unfailing patience and discretion. Most patients of this class have to be taught how to recognise the mental and physical signs of fatigue peculiar to themselves, other than the normal feeling of it. They must also be taught that some degree of fatigue thus manifested must be regularly incurred as wholesome tire. But both patient and physician must be guided alone by indi: vidual experience and judgment as to the amount of THE MENTAL SYMPTOMS OF FATIG UE. 465 effort. Feeling is often a misleading guide for doing or not doing. Many neurasthenic people are plied with recreation to “distract the attention,” and go on journeys in search of health, when it is not stimulation, mental or physical, that is needed, but rest. The physician may save many a patient from such a final strain, that would precipitate a break-down, by recognising the fact that his apparent ability to do things without fatigue, when the mental signs of it are present, is the strongest indi- cation that he has reached a dangerous degree of nervous exhaustion, marked so plainly by loss of the fatigue-Sense. In such cases, after a course of rest treatment, which must often be more or less modified, exercise becomes most important, in the form of gentle bodily effort and mental stimulation by recreation in gradually increased amount. The guide to the limitation of exercise is to be found in its effects, such as the slight return of restless- ness and insomnia at night, and the mental and bodily discomfort liable to appear on the following morning. Exercise may be pressed to the extent of not causing these effects; it promotes nutrition, and excretion of Waste products, the free action of the skin, etc. The physician will look to the therapeutics of tonics and nutrition, with careful attention to all the forms of elimination. But while he is doing this, the successful treatment of neurasthenia means the careful recognition of all its signs. The earliest indications for diagnosis, and the clearest for treatment—and often the only ones are the mental symptoms. It is the conditions of fatigue that are to be treated, and the study of the Wºrking of the fatigue-sense affords the safest and surest guide, although its Signs are so often negative. A cor- Tect, and fine appreciation of what the mind can do °nters into our commonest knowledge and experience, * We use the most familiar words to describe its Oper- ations. This paper has been written with the hope that it may be a help to the Systematic observation of some of 80 466 JNE W YORK STATE MEDICAL ASSOCIATION. the commonest and most valuable of clinical indications, both for prevention and cure. DISCUSSION. DR. GEORGE M. GoulD, of Philadelphia, was invited to open the dis- cussion. He thanked the Association for so courteously and unexpectedly calling upon him to participate in the discussion. As he listened to the paper, he could not but think that the author had been stealing the results of all his own cases for the past few years, and had epitomised the generalisation of what had been the outcome of his own observation. Physicians are prone to look upon organic factors as being the cause of disease, but, to him, the cause of disease is simply abnormal physiology. If we can get at the morbid physiology, so to speak, of the disease, we shall very often reach the root of the trouble. Turning to his own-special department of medicine for illustrations, he said that he had had bundreds of cases of disease of the eye which exemplified fatigue, hyperaesthesia, and abnormal actions of the mind itself, due to what is called “eye-strain.” The subject of eye-strain had received more than its share of attention, yet neurologists still fail to grasp the true significance of incipient mental disease, from the simple fact that they fail to perceive the morbid action of the physiology of the peripheral organs. Mind is only formulated vision, and all thinking is only an act done in pictures. If vision is abnormal in its action, it certainly must throw an irritational strain upon the mind, and an excessive stimulus goes into the cerebral centres which control vision and thinking, and sets up there an abnormal cerebral action. Every act of our mind and brain tries to translate it into cerebral products of vision. This results in a strain, which is more than the subject can stand. This is a general statement. The speaker assented cordially to the scheme presented by the reader of the paper. He had met with many illustrations where this everlasting eye-strain, especially in young women, results in nervous- ness and irritability of the mind, and in morbid products of intellec- tion, which finally result in hysteria. He believed that it even went further, and resulted in gastric disorder and in anaemia. Strange as this may seem, he thought observations directed to this point would sustain his statement. A case in point was that of a gentleman Who for twelve years had been tormented by various symptoms of mental trouble; his mind seemed to be giving way, and for several years he had to fight against suicide, but being a strong-willed man, he controlled this feeling. The gastric symptoms and various troubles of intellection and memory supervened, and he felt, as he expressed it, that if he “could only get behind his eyes” he might in some way do himself good. An examination of his eyes showed such a frightful, unsymmetrical astig”. tism, as to render his vision as much a source of irritation as if he had tried to lift a hundred-pound weight with a crippled arm. His Vision W&S a constant source of worry to the brain, and the brain in trying to interpret DISCUSSION. 467 these symbols of sensation was required to constantly act abnormally. It was not equal to this task, yet was compelled to do it, and so the man went on from bad to worse. This case was only a recent one, but he had had many similar ones, and they served to illustrate the philosophy of the mind which had been so beautifully set forth in the paper. DR. JAMES W. PUTNAM, of Erie county, said that he had been much interested in the paper, and in the discussion. He emphasised the im- portance of not forgetting that the impressions we receive come from very many different sources, as many sources as we have organs and special senses. To find the cause of the mental fatigue, we must seek in every avenue through which the mind receives impressions, and must make it a routine practice to examine a patient from his head to his feet, before making up our minds as to the location of the cause. Of course Dr. Gould, being an ophthalmologist, sees many cases of eye-disease, but the dermatologist sees many chronic cutaneous affections which are sending more or less annoying impressions to the brain, and in a large proportion of these cases, neurasthenia is the result of this irritation. Again, a man with stone in the bladder will suffer considerable nervous exhaustion, and so will a man suffering from haemorrhoids, and a child with a congested and inflamed prepuce. We must remember, also, that there are certain conditions of the blood which bring about nervous exhaustion. Habits of life may also have a similar result, as, for instance, in the various func- tional neuroses from occupation, such as writer's cramp, and telegrapher's Cramp. Many patients, after consulting an oculist and receiving full and Satisfactory correction for their errors of refraction, recover from their nervous exhaustion, and remain so for a certain length of time; but hav- ing once been victims of nerve exhaustion, there seems to be a certain instability of the cerebral health, and they are, therefore, apt to relapse, and to suffer from analogous symptoms, due probably to overwork. He had frequently seen patients with defective vision, and with no lithic acid in the blood, and no sugar in the urine, nevertheless become exhausted because they were not receiving a sufficient variety of impressions, their Work being, so to speak, too “humdrum,” so that it produced what might be called a “local neurasthenia.” DR. H. S. WILLIAMs, of New York county, said that not many years *89, a Very different view was taken of the mind from that now held. He W* taught, for example, that one department of the mind could operate independently of the other, and that, consequently, a person who had tired out one portion by studying mathematics constantly, could rest himself *Y studying another subject, as, for instance, geography. Now, this is to a certain extent true, but the general exhaustion of the mind includes the general functions of the mind ; and this extends, also, as the reader of the paper has shown, to the body. It was also taught formerly that a Person occupied with physical labor, when fatigued in body, could rest himself by 9°Cupying his mind; but those who have tried this, know it is not a Satisfactory way of Securing rest. The best way to develop the 468 NEW YORK STATE MEDIOAL ASSOOIATION. mind is not by developing physical fatigue, but by keeping the body in a healthy condition. It must not be forgotten that some individuals have such an inherent capacity for work, that an amount of physical exercise which would completely exhaust another one's mind, is only a stimulus to them. The mind, of course, cannot operate unless the body be in health; but if the body be fatigued, this fatigue will extend to the mind and render intellectual effort impossible. DR. E. M. MooRE, of Monroe county, had listened to the paper with great interest; but it was so distinctly metaphysical, that he had found some difficulty in following the author's line of thought. He only wished the author had gone one step further, and told us what the mind is. DR. E. D. FERGUSON, of Rensselaer county, remarked that probably the old definition here still held : “What is meant by the mind 7” “No matter.” “What is matter 7” “Never mind.” A REVIEW OF SOME INJURIES OF THE UPPER EXTREMITY. By E. M. MooRE, M.D., of Monroe County. November 16, 1892. When asked by your committee to prepare an address on surgery, I assented upon condition that I might re- capitulate my work on the upper extremity, which, in my opinion, represented certain corrections and additions to our antecedent knowledge. The dictum of Solomon that “there is nothing new under the sun,” receives frequent confirmation in the prosecution of our re- searches. An observation is made and recorded, and not attracting attention at the time, is forgotten until it is again observed by some One possessing no knowledge of the earlier observations. I do not know that I have been especially unfortunate in this respect. Whatever further reading may show in relation to the conditions I am about to describe, it has thus far been remarkably free from the annoyance of the discovery of correspond- ing antecedent observations. But this is not a matter of much moment. The real interest lies in the relation of the condition expressed, and the current belief and practice of the profession. The views I shall offer you are original with me, and I have had to sustain a polemic on behalf of most of them. An extensive experience has confirmed me in my belief of their correctness. I will at first call your attention to fractures of the clayicle. Whatever peculiarity there may be in my rationale of the causes of the displacement and difficult *ctification of this fracture by the methods usually em- ployed, I may say that the conclusions arrived at were Purely the result of ratiocination. These were confirmed by subsequent experience, and have not undergone any *ification since their first announcement. 470 NEW YORK STATE MEDIOAL ASSOCIATION. First, then, as to the methods usually employed for the purpose of rectifying the displacement incident to these fractures. As every surgeon knows, these consist in the use of a fulcrum in the axilla over which the humerus is moved as a lever, so as to throw out the shoulder and draw the fractured ends into apposition. There are various methods of handling the arm. We have the quilted bandages of Boyer, the shawl of Liston, the sling of Fox, as well as many other forms, but the rationale is the same in all of them. The other general plan consists in the use of some form of the figure-of-eight bandage. Dr. Sayre has proposed, as you all know, an adhesive plaster dressing. The arm is held to the side ; then a Strip of plaster is carried around the arm near the axilla, and the other end drawn around the body to pull the shoulder backward. I regard this as a great advance over the methods by the axillary pads and the figure-of- eight bandage. But it fails of a better result by not making the clavicular fibres tense, which can only be accomplished by carrying the elbow backward. Neither does it move the scapula around the thorax toward the spine, as surely and as far as by the action of the shoulder bandage, combined with the backward position of the elbow. After the publication of my paper, I learned that a fractured clavicle had been treated by carrying the forearm behind the back. It had occurred to me that this would fulfill the indication, but it was rejected because of its painful character. The symptoms of fractured clavicle are very constant. The shoulder goes downward, inward and forward, in obedience to the action of gravity, the shape of the thorax and the tonic power of the pectoral muscles; and as a sequence of this altered position, the inner frag- ment almost surely rides the outer one. It is of this common condition only that I speak. º It is well known that the treatment of this fracture 18 conducted generally upon two plans, with a great variety IWJURIES OF THE UPPER EXTREMITY. 471 of modifications of detail. One is by the use of the axillary pad, which is the fulcrum for the humeral lever; the other is by the figure-of-eight bandage, which draws the shoulders backward by a band passing around the axilla. There are other plans, but these prevail. The tension of the clavicular fibres is the chief indi- cation for rectifying the déformity. There are other considerations, however, among the principal of which is the position of the scapula. When we place a patient in a chair, and, standing behind him, seize the upper part of the arms near the shoulder and draw them back- ward, the replacement of the fractured ends becomes perfect, almost with certainty. But when, with more force, we use the axillary pad or figure-of-eight bandage, the restoration is so rare that many surgeons assert its impossibility. I criticise the axillary pad, because it en- sures the relaxation of the clavicular fibres of the great pectoral. If this results from its action, we lose the antagonism of the sterno-cleido-mastoid, and therefore no matter how high we elevate the shoulder, the end of the inner fragment will be the bigher. But if the shoul- der is carried backward, and the clavicular fibres of the pectoral muscle are rendered tense, the riding, inner fragment will be brought down, thus securing perfect apposition. This results from the well known treatment by recumbent posture, and from the attitude in the chair, as above described. * The attachment of the great pectoral to the humerus, it will be remembered, is quite peculiar. The muscle makes a half turn upon itself and is inserted for a full inch-and-a-half along the bicipital groove, the thoracic fibres running to its upper, and the clavicular to its lower Pºrt. It must be obvious that the tension of the fibres in the same muscle will vary according to the position of the humerus. If the arm is carried backward, it moves from the shoulder joint as the fulcrum, the lower por. tion of the muscular insertion describing the larger Circle, thus involving a greater tension of the clavicular 472 NEW YORK STATE MEDICAL ASSOCIATION. fibres. By this tension we antagonise the sterno-cleido- mastoid muscle, and if the shoulder be carried back far enough, the apposition will be perfect, provided no inequality of the fractured surfaces prevents, which will often happen in oblique fractures even when the length is fully obtained. Before presenting a plan of treatment, I will criticise, in the first place, the axillary pad. As the large end of this pad is placed upward, it operates of course upon the humerus just at the border of the axilla. Its ration- ale is that of a fulcrum for the humerus as a lever. The motion on the fulcrum, if a mathematical line, is nil. The pad is opposite the attachment of the clavicular fibres of the pectoral muscle. At the point of their insertion there is no motion, no matter how much force we may use. The shoulder is thrown out as far as the thoracic fibres of the pectoral muscle will allow. The upper end of the bicipital groove is the point of insertion for these fibres, which are put upon the stretch, because it is removed from the fulcrum. The clavicular fibres of the pectoral are relaxed, and kept so, and the Sterno- cleido-mastoid draws up the inner fragment. I also criticise the figure-of-eight bandage for produc- ing a similar relaxation of the clavicular fibres of the pectoral muscle. This bandage acts upon the lower border of the muscle, which is composed entirely of thoracic fibres, and the more tightly it is drawn, the more will it curve its axillary border, and incidentally shorten it. The fibres of the clavicular portion are not bent, and of course not shortened. Thus they are inevitably relaxed by the drawing in of the humerus. It will therefore be seen that, in the effort to carry the shoulder out by the axillary pad, or backward by the figure-of-eight bandage, the condition of tension of the thoracic, and relaxation of the clavicular fibres of the pectoral muscle results. The indication, therefore, to be fulfilled, is to reverse the action, and by carrying the humerus backward, make tense the clavicular and IWJURIES OF THE UPPER EXTREMITY. 473 relax the thoracic fibres of the pectoralis major muscle. This motion is at the shoulder-joint as a pivot. The ten- sion of the pectoral fibres is now reversed—the lower portion of the bicipital groove is moved through a greater circle than the upper, and the clavicular fibres are rendered tense in proportion to the distance the humerus is carried back. No plan that leaves the humerus perpendicular can make the clavicular fibres tense. The scapula must also be moved as near the spine as can be borne, for the obvious reason that the thorax is the most salient at this part, and a sliding of the Scapula thus produces a movement of the shoulder backward and outward. As it goes back it rises. I also make criticism upon the effect of the shawl, Fox's or Dessault's band- age, in their operation on the scapula. If the hand be placed upon the inferior angle of the scapula and the shoulder raised, keeping the humerus perpendicular, it will be seen that the scapula moves forward upon the thorax at its lower border. This criticism, however, does not obtain with reference to the figure-of-eight bandage. This is in the wrong direction, and although it is the lower angle, it nevertheless allows the whole scapula to Come forward, and thus shorten the broken clavicle. The obvious indications in the treatment of this frac- ture, therefore, consist in the use of any bandage or posture that will carry the humerus backward and hold it toward the side. The effect of carrying the arm back- Ward is to move the scapula toward the spine, thus ful- filling the first important indication. But besides this, as Stated above, the clavicular fibres are rendered tense by this attitude, and thus the only remaining indication ls fulfilled. Some aid may perhaps be obtained by lift- ºng the shoulder from the elbow, but this is subordinate. In order to obtain the results stated I have resorted to Various devices; but to treat fractures well we must be * to find our appliances in every house, and after Imuch experimenting I use a shawl or piece of cotton 474 NETW YORK STATE MEDICAL ASSOCIATION. cloth, which, when folded like a cravat, eight inches in breadth at the centre, should be about two yards long. Placing this at the centre across the palm of the surgeon, he seizes with his hand the elbow of the patient, which corresponds with the broken clavicle. The two ends of the bandage hang to the floor. The one falling inward toward the patient is carried upward, in front of the shoulder and over the back, making a spiral movement in front of the shoulder. This is intrusted to an assist- ant. The outer end is then carried across the forearm, behind the back, over the opposite shoulder and around the axilla. This meets the other end, which may be carried under the axilla and over the shoulder of the opposite side, thus making the figure-of-eight turn around the sound shoulder. This twist, it will be seen, makes also the figure-of-eight turn around the elbow of the affected side. I therefore style the bandage : “THE ELBOW FIGURE-OF-EIGHT.” The forearm should be sustained by a sling which raises it to an acute angle, in order that gravity may assist in moving the whole arm backward. This is best done by a simple strip three or four inches wide, which may be pinned to the shoulder. Any tendency on the part of the shawl to slide from the shoulder may be arrested by a pin thrust in at the crossing. The bandage at the elbow is kept in place by folding the upper part that fits the arm and securing it by a pin. This makes a sort of cup for the elbow. The bandage is worn with ease, except on the sound shoulder, which is vexed by the pressure of the Ordinary figure-of-eight. It will be observed that the shawl, as it passes in front of the arm, does not press on the axillary border of the pectoral muscle, and therefore avoids the objection of the ordinary figure-of-eight. At it passes over the fore- arm, and over the opposite shoulder, it lifts up the arm like the ordinary shawl bandage. INJURIES OF THE UPPER EXTREMITY. 475 476 NEW YORK STATE MEDICAL ASSOCIATION. Additional evidence of the correctness of the views herein stated, is to be found in the fact that dislocations of the clavicle are almost surely retained by it while the patient keeps the erect posture. This, I think, cannot be said of any other plan. Nothing but absolutely full extension can retain the luxated surfaces at either end Of the clavicle. The word perfect is one of doubtful application to any repair of fracture. But we use the term, and I think it may be correctly applied to all fractures that are brought to a correct line and unembarrassed by redun- dant Ossific deposits, as in the Osteophytes so common in fractures of the neck of the thigh bone, or the union that takes place with a parallel bone, as sometimes occurs in the forearm. By the figure-of-eight from the elbow the whole length of the bone is attained, and the frag- ments brought into line. Most of the cases, if carefully watched, show a perfect result when measured by the standard above delineated. I find it necessary to see the patient for a period of one or two weeks, tightening the bandage daily. At the end of this time, the adjust- ment is apt to be complete, or nearly so. The fractured ends do not inosculate, but nature remedies this defect. Closely associated with these considerations as a whole, we may speak of the luxations of the clavicle. These are not common; many surgeons have spent a life- time without meeting a single one. The authors dis- pose of their management very summarily. They simply recommend the use of a clavicle bandage. The diagnosis is easy. Whether at the sternal or the acromial end, they are readily reduced by seizing the arm below the shoulder and drawing it backward. The moment this traction is relaxed, the tension of the muscles, added to the weight of the limb, produces consecutive luxation. It is perfectly palpable that the least shortening of the clavicle will throw the bone out of place in either of the dislocations mentioned. I have not been able to learn from any surgeon of a complete and satisfactory result INJ URIES OF THE UPPER ExTREMITY. 477 in his treatment, except in two cases, one treated by Dr. McGraw, of Detroit, and another by Dr. Pancoast, of Philadelphia. But both were placed in the recumbent posture and strictly confined to bed. One had a thick band carried under the axilla and tied to the bed-post. As you all are aware, the recumbent posture has long been considered the only sure mode of rectifying frac- tures of the clavicle. But only young females who dread the deformity will submit to this treatment. I have now collected eighteen cases, treated with the patient in the erect posture, by men widely separated from each other, and with absolutely perfect results in most of the cases. This would be impossible but for the fact that the rotation of the Scapula On the thorax throws out the acromion, and secures the full length of the clavicle. The position attained by the use of the bandage, is also favorable to the rectification of most, and perhaps all of the fractures of the scapula. These injuries are not frequent. The most common among them are those where the lines run across the body. I have met with but two of these, one was in a gentleman who was thrown from his berth by the lurch of the ship on his voyage from Europe to New York. He fell under the care of the late Prof. Carnochan, who treated him with Boyer's apparatus for fracture of the clavicle. His suffering Was intense. After remaining in the city for a fortnight, he reached his home, and I changed the bandages for Fox's pad and sling, but without any marked relief. His recovery was very slow. The next case occurred after the bandage had been used by another physician, from Whom I first received the intimation of its bene- ficial application. The fracture was in a German laborer, and he had passed a week of pain before coming under treatment. The relief from the bandage was im- "ediate and marked, but not so great as I think it Would have been if employed at the beginning. The first recipient of benefit from this bandage was a railroad 478 JNETW YORK STATE MEDICAL ASSOCIATION. laborer living in a hut near the border of the track. While walking alongside the road he was struck on the scapula by the projecting frame of a passing locomotive, and sent headlong into a ditch. Another laborer living close by, moved him into his cabin, and placed him upon a lounge, from which he could not be induced to stir for any purpose, the posture and absolute quiet being his only relief. A young physician from a neigh- boring town was summoned, and after getting the man into a sitting posture with much trouble, he dressed the fracture. In reporting the case to me a few days later he compendiously stated it thus : “I found the fracture of the body of the scapula very readily, its line running across it below the spine ; but I did not know what to do, so I applied your bandage for fractured clavicle. The relief was immediate, so much so that he stood up and walked to his own home, which was about half a mile distant.” This surprising statement of my young friend induced me to use it as stated above. I think a little reflection will convince any one of the correct rationale of such relief. The movement of the scapula toward the spine will bring it into closer apposi- tion with the thorax, which thus becomes the natural splint. But besides this, every muscle attached to the exterior of the Scapula, is relaxed except the Supra- spinatus, which being above the spine, can have no effect upon the fracture. The infra-spinatus, teres major and minor, as well as the sub-scapularis, are relaxed by Carry- ing the elbow backward. Of the muscles attached to the scapula and the thorax, it is evident that the rhom- boideus is relaxed, and the elevation of the bone, as the result of the bandage, also relaxes the levator anguli scapulae. The serratus magnus is placed upon the stretch, and being attached to the whole base of the scapula holds it steady as it is carried backward between the two forces. Of fractures of the neck of the scapula I am not sure that I know anything. Theoretically, I suspect the plan INJURIES OF THE UPPER EXTREMITY. 479 of carrying the elbow backward would bring the sepa- rated fragments together. One day while in Jackson, Michigan, I was walking in company with a physician, who suddenly stopped on meeting a man, and Com- menced questioning him with reference to the condition of his shoulder. The patient pronounced it very satis- sactory. Turning to me the doctor remarked, “I made a diagnosis in this case of fracture at the neck of the scapula, and I treated it with your bandage, making no change as the relief was so good.” - I have, as you perceive, shifted the responsibility of suggesting a sort of panacea for the ills of the broken scapula, but I am not quite done with its uses. I had a friend who always insisted that the position secured by it, was the most comfortable one for retaining the head of the humerus in its socket after the reduction of a dis- location at the shoulder joint. But I never employed it for this purpose in my own practice, preferring to stuff the axilla with a compress, and throw a bandage around the humerus. But about two years since a man was brought to me who had been successively in the hands of two surgeons. The first one had undoubtedly re- duced the bone to its place in the glenoid cavity, and had attempted to keep it from the consecutive luxation Which every surgeon knows is so easy after the reduc- tion has been made at this joint. But the patient was so uncomfortable the next day that he applied to another Surgeon, who did nothing. The patient then came into my hands. I recognised the injury as one well known but very rare, a luxation of the head of the humerus on the dorsum scapulae. Manipulation easily replaced the bone, and I proceeded at once to retain it in place by filling the axilla with cotton and throwing a bandage *Qund the thorax and arm. But during the handling, a little shock was felt, and the head of the humerus had Pºssed out on to the dorsum scapulae. My interest was *Oused, and I again reduced the bone, and found that if the humerus were brought in a line with the thorax 480 NEW YORK STATE MEDICAL ASSOCIATION. perpendicularly, it slipped out. This Irepeated, and thus the failure of the surgeon who first reduced it was ex- plained. Here was a dilemma. The experience of my friend, above alluded to, came to my mind. The elbow was carried backward, the clavical bandage applied, and all trouble was at an end. Of the fractures of the superior end of the humerus, I speak only of those that follow the line of the epiphyseal junction. About twenty years since I had an experience that led to a new exposition of the pathology, and a simple and quite perfect method of treatment. Permit me to read Some of my paper : Great confusion has existed, and still exists, as regards the exact nature of fracture of the humerus through the line of its superior epiphysis. After the very clear state- ment of symptoms that has been given by Sir A. Cooper, Prof. R. W. Smith, and Prof. Frank Hamilton, one would hardly suppose that error of diagnosis would oc- cur; but it does occur and constantly. I think this results from the fact that a clear conception of the change of position has not been put forth, and more than this, and growing out of it, no method that secures reduction of the fracture has thus far, according to my knowledge, been proposed. If there had been a good method, especially if it were connected with its ration- ale, the eaſperimentum crucis would have been present to clear up doubt of diagnosis as well as rectify deform- ity. We must, therefore, look to the configuration of the epiphyseal junction, to explain the position of the bones, after the separation. Taking the head of a bone from a subject ten years of age parted by maceration, We find the angle made by the junction of the plane, pro- jected through the anatomical neck (and which makes about two-fifths of the whole surface) with the plane, passing below the tuberosities, measures about one hun- dred degrees. gº “The development of the humerus,” says Gray, “is INJURIES OF THE UPPER EXTREMITY. 481 EXPLANATION OF PLATE. Fig. 1 represents the head and part of the shaft of the humerus, from a boy ten years of age, and is photographed life-size. These have been separated by maceration, and replaced. Fig. 1 gives a profile of the bone re- garded from its external aspect. The dotted line, A, indicates the ana- tomical neck. The epiphyseal line, B, is seen to cor- respond with the anatomical neck along nearly one-half of its length, and diverges nearly at a right angle below the tuberosi- ties. º; 3 represents the same bone in the position it retains after fracture along the epiphyseal line. The smaller facette of the superior diaphyseal surface is locked with the larger facette of the correspond- ing surface of the head. Fig. 3. 482 JWEW YORK STATE MEDICAL ASSOOIATION. by One Ossific point for the shaft, one for the head, and One for the greater tuberosity. At birth the shaft is Ossified nearly in its whole length, the extremities re- maining cartilaginous. Between the first and second years, the centre for the tuberosities makes its appear- ance, usually by a single Ossific point, sometimes another for the lesser tuberosity, which does not appear until after the fourth year. By the fifth year, the centres for the head and tuberosities have enlarged and become joined, so as to form a single large epiphysis.” The constancy of the symptoms makes this fracture differ from most that occur. The projection of the angle of the diaphysis, making the singular appearance about One or two inches below the acromion, according to the age of the patient, and the shortening of the humerus from half to three-fourths of an inch, will render the diagnosis so plain that the difficulty should not be mis- taken for any other injury. But it is constantly mis- taken, and the mistake is acted on, severe and protracted extensions being made to reduce relaxation. A little irregularity is found on the surface, but the plane is pretty accurate. On the surface of the head is found a depression into which, if the shaft is moved in- ward about one-fourth of its breadth, there is a coapta- tion, which arrests the movement of the bones, and which also fixes the shaft at the point which Smith and other observers have described. The change of coaptation in the facettes explains the constancy of the symptoms SO regularly noticed, by which the projection forward of the diaphysis replaces the rotundity of the head. This change has a little analogy to dislocation of the knee laterally, by which the external condyle of the femur is jumped, as it were, into the cup on the internal condyle of the tibia, and retained by the tension of muscles. The posterior facette of the diaphysis, by the force of the blow and action of the muscles, becomes fitted to the anterior facette of the head. Of course, in such injuriº as fractures, the muscles are apt to acquire their greatest INJURIES OF THE UPPER EXTREMITY. 483 tension at the moment of separation. Those that act in the direction of the shaft press upward. The head is set upon the shaft at an angle, and if there were no other cause, they would have a tendency to roll the now mova- ble head upon the glenoid surface. But besides the muscles, parallel with the shaft, there are those attached to the tubercles, whose traction would now roll the head so as to produce dislocation of the facettes. This posi- tion throws the superior edge of the diaphysis forward, and then retains it there. It is the observation of all, that traction will cause the deformity to disappear. That traction does not produce reduction, is also equally evi- dent, for the reason that it does not remain in place after it appears to be reduced. I think, however, that the re- lief of the deformity by traction is not as great as ob- servers have thought. When extension is made, the head will undoubtedly work on the projecting angle of the diaphysis, and the tense deltoid, pressing the shaft back, will restore the rotundity of the shoulder. But the reduction of the luxated surface does not take place, and the cessation of the extension finds the capsular muscles ready to roll the head over and project the diaphysis forward. In consequence of the very common error of diagnosis, and the belief that a luxation is present, the attempt at reduction is made by exten- sion. The evidence of the mistake in supposing that restoration had occurred after extension, is quite com- plete, for no one claims that the appearance of reduction is permanent, the symptoms recurring as soon as the extension ceases. In view of such a displacement, the natural mode of reduction would seem to be one that would carry the Giaphysis backward, and thus restore the corresponding facettes to their normal positions. This I succeeded in doing, not by extension, but by carrying the humerus Jºrd and upward. The head will roll upon the glenoid surface in any motion of the arm until restrained by its Capsule. While the humerus is still back of the 484 JNETW YORK STATE MEDICAL ASSOCIATION. central line of the body, the head is rolled upward, and long before the humerus is brought up perpendicularly, the capsule at the lower border of the head has become tense, thus holding it firm ; while the humerus being drawn up and restrained by its muscles, slides the diaph- ysis backward, producing a coaptation of the corre- sponding facettes. If these facettes have changed their position, or rather if one is entirely thrown forward, and the internal facette of the diaphysis is brought and re- tained in contact with the external One of the head, it must be obvious that when the shaft is hanging perpen- dicularly, the head must be rolled in such a position that the arm, if there were no fracture, would be nearly at right angles with the body. Of course the head will roll around in any direction, in consequence of the lock of the surfaces, unrestrained by any influence except the capsule. By a firm grasp of the thumb on one side, and the fingers on the other, the head may be so far restrained as to enable one to elicit crepitus. This hold is not secure enough to answer the necessities of reduction ; but when the head is rolled over until the capsule becomes tense, the restraint will become perfect, if the force be applied in a direct line. A very slight extension of the humerus will now pre- serve the relation of the two surfaces. While this mod- erate extension is maintained, the arm can be brought down to the side, all deformity having disappeared; in short, a reduction of the fracture has been accom- plished. From these statements, it becomes apparent, that this fracture possesses many of the characters of a luxation. The bones after separation are moved into and retained in a definite place in obedience to definite forces. A fracture in other than an epiphyseal line is, as a matter of course, irregular at its surfaces; and while We may find that a general law may govern fractures at Cer- tain points, we also find frequent variations incidental to the form of the surfaces. No better illustration of this INJURIES OF THE UPPER EXTREMITY. 485 truth can be found than in the fractures immediately below, that is to say, at the surgical neck, for in these it is well known that the usual displacement is that of the shaft inward, in obedience to the pectoralis major and latissimus dorsi. But even in this fracture, there are numerous cases where the obliquity of the surfaces has caused a reversal of the usual relation. The admission is made by all that no plan of treatment is likely to succeed, and that the characteristic deformity appears upon the removal of dressings; but I have found no difficulty whatever in the use of Swinburne’s exten- sion plan. The axillary border has been sufficiently firm to bear the extension necessary, and the axillary band by passing over the head of the humerus assists in exten- sion. I find the pressure is not sufficiently great to dis- turb the axillary nerves; indeed, the method leaves nothing to be desired, and the facility with which it may be applied and worn renders it quite perfect. In every Case it has entirely succeeded; but I think it can do this Only when reduction has occurred. It has been my fortune to see but a single case at its Commencement, and that after severe and unsuccessful attempts at reduction. Two others having been un- Successfully treated, or not treated at all, were restored by me at periods of time varying from two to three weeks after the accident. It is well known that fractures Separated after adhesions have formed, are not quite as easily retained as those which are recent. The swelling and the accommodation to new positions are circum- stances that aggravate the difficulties. Yet in each of the three cases just mentioned there has been a perfect *sult. The restoration to full use was accomplished in less than thirty days; for the adhesive process is rapid, and, where we do not delay for Osseous deposit, the use of the arm is soon possible. "he following cases confirm the correctness of the º as Well as illustrate the rationale of displace- Iſlent. 486 METW YORK STATE MEDICAL ASSOCIATION. John Duff, fourteen years of age ; September, 1868. Fell from a loaded wagon, striking on the right shoulder. He was seen two hours after the accident by a well-instructed physician, who committed the error of diag- nosis formerly alluded to, in regarding the case as one of dislocation. Violent traction must have been made, for two men pulled at the arm but when the extension ceased the deformity reappeared, although the supposed luxation was believed to have been reduced. This having failed, it was renewed the next morning, in consultation with another physician. The patient was then sent to me the same day. The characteristic symptoms were present as already detailed. It is also to be noted that on rotating the arm before reduction there was no crepitus until the head was grasped firmly. The bandage and splint were worn during the period of four weeks. The restoration was absolutely perfect, and so remains, as proved by a recent examination. Nelly Coates, sixteen years of age. Fell from a height of about six feet, striking on the shoulder in front. The patient was seen immediately by the family physician, but he did not recognise any displacement. Four- teen days later she was seen by another physician of great experience, but, on examination, he also thought there was no displacement. The patient still suffering, a third physician was called, who thought there was luxation. I saw the case seventeen days after the accident. The symp- toms, as detailed in the résumé, were all present. It was treated by first. reducing the displacement, and the application of Swinburne's dressing, which was worn about two weeks. A year afterwards the arm was examined, and the result was so perfect that no difference in form or motion could be discovered. Charles Bunnel, six years of age ; on March 15, 1873, fell, as it was thought, on his shoulder. He was seen by Dr. C. Hammond, of Monroe county, on the day following, who diagnosticated luxation, but, On making further examination while the patient was under the influence of ether, he “found the movements of the shoulder perfect ;” and getting no crepitus supposed the deformity resulted from ecchymosis. At the end of two weeks the swelling had subsided, and the prominence Was more marked. At this time (March 18, 1873) I saw the patient for the first time. The boy was the unfortunate subject of infantile paralysis, which had occurred between the first and second year, and affected the arm which was broken. My views had been pretty well settled before, but now I had a case, which, though not quite, was almost as capable of demonstrat- ing the facts, as an autopsy. I need not remind the profession of tº shrunk muscles and lax skin that invest the bone in such cases. As * usual, there was some muscular power ; but while in the strong and healthy there is much diminution of utility in the arm, in this patient the little he possessed was gone, and hence its restoration became a matter of unusual interest. The adhesion of the bones was readily broken up by carrying the arm upward. The muffled crepitus was obvious, and the restoration perfect. Three months afterwards, Dr. Hammond in a note tº me remarks, that the “restoration is complete in every respect.” INJURIES OF THE UPPER EXTREMITY. 487 Aesoſºme.—1st. The symptoms of this fracture are striking and uniform. The shaft of the humerus is so inclined as to carry the elbow a little backward and Out- ward, while the superior end of the shaft is brought forward, so as to make a prominence less rounded than the head, and lower down. This is usually found about an inch and a half below the acromion (the distance varying a little with the size of the youth) and near the coracoid process. The curved line from the acromion down to this projection has a long sweep, instead of the small sphere of the natural head. This appearance is pathognomonic, and may be safely trusted in diagnosis, without insisting upon crepitus, which, as in other epi- physeal fractures, is not clear and sharp, as when the fracture is of bone, but is muffled. When the arm is moved gently, and without grasping the head, the pecu- liar lock of the surfaces is sufficient to cause the head to rotate, and thus the timid practitioner fails in getting his pathognomonic sign; but if the head be firmly grasped, it can not only be felt in the glenoid cavity, but can be held sufficiently firm to get this muffled crepitus by rotating the humerus, or by carrying the elbow in- Ward and thus rubbing the two surfaces on each other. In addition to these striking symptoms we may add the fact of a shortening of half an inch or a little more in the length of the humerus. When the two shoulders are inspected from behind, the impression produced on the mind of the surgeon is that described as sub-luxation, for there is a slight flattening of the shoulder. The breadth of the shoulder is also increased when seen in profile. The motions of the arm are somewhat circum- scribed. The ability to carry it upward and forward, as Well as upward and outward, is impossible much be- yond a right angle with the body. . 2d. The reduction of the fracture is effected by carry- i. the arm forward and upward to the perpendicular Ile. * The retention is effected by moderate extension 488 NEW YORK STATE MEDICAL ASSOCIATION. while bringing the arm down to the side, maintaining this slight extension until dressings for the purpose of continuing it are applied. Swinburne's method fulfills the indication easily and perfectly. 4th. Even if not restored, the arm soon becomes useful, and nature gradually rounds off the prominence of the diaphysis, and elongates the capsule at the lower border, allowing the upward motions to improve. Professor Robert Smith acknowledges the difficulty of rectifying the fracture, and quotes Mr. Tyrell as suc- ceeding by dressing the fracture with the arm extended from the body. But this, in his experience, was an exceptional case. The extraordinary projection which Professor Smith figures in his book is so remarkable that once seen it can never be forgotten or mistaken. This is the only form he speaks of, and it is very rare. I think it accounts readily for the general ignorance of surgeons on this topic. I have photographs of two such cases, and they confirm the correctness of Smith’s engraving, which I had formerly thought to be an artist’s exaggeration. The deltoid in these cases is split, and the end of the diaphysis comes forward under the skin. (See portrait.) The finger can be put into it as in a cup. But in by far the larger number of cases the diaphysis remains covered by the deltoid, and thus the sharp edge is thickly covered and the shoulder presents the appearance of moderate flattening. Every case of this kind that has been sent to me was regarded by the attending Surgeons as a sub-luxation, and unsuccessful attempts at reduction had been made. - As regards the management of fractures and disloca- tions of the elbow, I may say that I have found the diagnosis of the lines of fractures often very difficult, owing to a moderate ecchymosis. As a teacher, I looked around for some method which would be entirely safe pending the clearing up of the diagnosis, and also for One that could carry the cure to a successful conclusion. Some teach that the extended position is the proper One, on INJURIES OF THE UPPER EXTREMITY. Photograph of a young man sixteen years of age, the end of the diaphysis having penetrated the deltoid muscle. 489 49() NEW YORK STATE MEDICAL ASSOCIAT ION, the ground that it enables the patient to maintain a good carrying power ; but I have found that by this treatment the use of this marvelous member is reduced to the mean position of a mere hook for burdens. The old rule in the after-treatment of luxation of the elbow, of placing the forearm at right angles to the arm, is one that we cannot abandon on any terms. I have seen several cases where there was an epiphyseal fracture of the lower end of the humerus, which was mistaken for a dis- location—an error that even a good surgeon may make, because the forces inducing displacement are precisely the same in both injuries. The tissue does not produce the sharp grating of an ordinary fracture, and even with a dislocation there is some crepitus as the bones go into place. In dislocation, the reduction soon after the acci- dent is very easy, and therefore does not differ percepti- bly from the muffled crepitus of an epiphyseal fracture. All authorities agree that, after a reduction of the luxa- tion of both bones of the elbow backward, the forearm should be kept at right angles to the arm ; but this is necessary only for a short time, just long enough to allow of the repair of the capsule. In a case of fracture, if the arm be liberated from the sling at the end of this short period of time, it gradually drops down to the angle of 135°, which is the compromise between the flexor and extensor muscles. It then becomes firmly united in this false position. The case is aggravated where the extension is made by splints. The numerous modes of fracture of the lower end of the humerus, the epiphyseal, that of the external and internal condyle, as well as that of the neck of the radius, are more or less obscure of diagnosis. The fractures of the olecranon are so easily diagnos- ticated that no error can be made in them. That they should be treated in the extended position requires nº assertion. For fractures of the internal condyle, it seems to me that the rectangular position, and even one of " acute angle looking upward, is the proper method, INJURIES OF THE UPPER EXTREMITY. 491 because it relaxes the muscles which originate from the broken fragments. Now, as I regard the knife-and-fork function as much more important than the carrying One, my effort in elbow injury is to see that the hand can be carried up to the neck on the side opposite to the broken arm, knowing that gravity is pretty sure to bring the forearm down. I have found the same position efficient in the treat- ment of fractures of the external condyle. In them the muscles of origination are tense if the forearm be placed at right angles to the arm. Such a contradiction in theory with correspondence in results should be ex- plained. For this purpose I experimented upon an arm of a boy ten years of age, which had been amputated at the shoulder-joint. I cut down through the tissues in a line with the fracture of the external condyle, merely split- ting the muscles so as to allow the introduction of the points of a pair of bone-cutters, with which I made a fracture. On moving the forearm up and down, it was found that the fragment was drawn close up to the shaft When the forearm was carried up, in consequence of a well- known anatomical condition. You will remember that the fascia over the external condyle is very dense, like a broad tendon, and is inserted along the external line of the humerus. This, when tense, makes the most perfect of splints. Fracture of the neck of the radius is one of the rarest. It is obvious that it is our first duty to relax the biceps muscle by bringing the forearm to the rectangular posi- tion, or even to an acute angle. Let me Say here a few words with reference to the dislocations of both bones of the radius and ulna back- ward. Every surgeon knows with what ease the reduc- tion is made when the luxation is recent, and what difficulty attends it when a few weeks have elapsed before it is undertaken. It is also easy to recognise the reduction when made, for the anatomical points are very marked. In the county of Livingston, some years since, 492 NEW YORK STATE MEDICAL ASSOOIATION. four law suits were brought because of an alleged non- reduction of such a luxation. It was bitterly contested by the surgeon in attendance, who was perfectly sure of the reduction, and of this fact I was quite as certain as the surgeon himself. But at the end of two months it was also manifest to every one that the luxation was complete. Only one inference was possible—consecutive luxation had occurred. Consultation of the authorities furnished no information. It is not necessary to say anything of these trials, but it is significant that, even in the limited area of western New York, two other cases should appear to show how easily consecutive luxation of these bones may occur. In one of these cases the Surgeon placed the arm on a pillow, with the forearm at right-angles to the arm, and the swelling and pain were So great for several days that no manipulation was undertaken. The swelling also served to obscure the consecutive luxation, and the surgeon was blinded to the fact that there was any re-luxation in consequence of his firm conviction that he had reduced the bones to their proper place. Even if the forearm had been placed at right-angles to the arm and laid on a pillow, the muscles would slowly but surely bring it down to the angle of 135°. The question to be solved was the angle at which the luxation would be reproduced, but no light whatever was thrown upon the subject by surgical writers. An- other case was brought forward where the arm was placed on a pillow for the night, and at the morning visit a re-luxation was discovered. It was again reduced, and the forearm being retained by a splint at right-angles to the arm, no further trouble was experienced. After appearing as a witness on the first trial, I reduced a similar luxation in a young woman. The bones went into place easily. I then carried the forearm out to an estimated angle of 135°. The luxation occurred at Once: This patient was nineteen years of age. At a later period I reduced a similar luxation occurring in a man about forty years old, but the re-luxation did not appear when INJURIES OF THE UPPER EXTREMITY. 493. the forearm was carried out to the angle above described. In neither case was there any evidence of a fracture of the coronoid process. These observations prove that consecutive luxation will sometimes follow when the natural relation of the muscles is allowed full play. I have alluded above to my desire as a teacher to de- vise some correct method for the early stages of fractures of the elbow, and thus give the time necessary for correct diagnosis and subsequent treatment. With reference to the luxation of both bones backward at the elbow joint, the necessity of following the common advice of authors to place the forearm at right-angles to the arm, is obvi- ously correct. It is my judgment that in all fractures except those of the olecranon, or of the ulna just below the articulation, the same position should be taken. But if the fractures are treated in any fixed position there is apt to be more or less interference with the motion of the forearm. The least tilting of the fragments may inter- fere with full extension or flexion. Every surgeon prac- tices passive motion, more or less. But my method, which I believe to be original, and which I have practiced So long, Secures all the advantages of passive motion and Something more. At the end of about ten days I change the angle a little by the application of side splints of trunk boards, or their equivalent. At the end of two days another set is fitted at a more acute angle, and again another set at the end of two more days. The patient should now be able to carry the hand up to the neck on the side opposite the injured elbow. Two days later the reverse movement is made, and continued down nearly, but not quite to, the position of extreme exten- Sion. The arm is carried upward and backward as before. The change of position is so little at a time that it does not interfere with the union, and the frag- ºnents are moulded into place or out of the way. tº of the fracture of the radius at its lower end near the 19nt which receives so much elucidation from the obser- Vations of Professor Colles, I may say, that I have 494 NEW YORK STATE MEDICAL ASSOCIATION. departed widely from the views heretofore entertained by the profession and still mostly held by it. Professor Colles found surgeons constantly blundering in supposing that when this fracture was present they were either dealing with a sprain complicated with blood clots, or with a dislocation of the wrist. This latter error is not now often made, but was formerly quite frequent. At the last meeting of the Surgical Association, Dr. Roberts, of Philadelphia, wrote an elaborate paper on this subject. He sent to the Fellows a series of ques- tions especially referring to the treatment of the fracture. He also solicited the general experience as regards the results, especially with reference to the pain and stiff- ness that so often occur. I must confess that their state- ments make rather dismal reading. A great variety of splints had been used, but the results were very nearly similar. Dr. Roberts seems to draw the same conclusions that I do, viz.: that splints and confinement are worse than useless. He places a band of adhesive plaster around the wrist, but unless this is drawn too tightly for the comfort of the hand, I cannot see in it anything but a placebo. But his method is an advance, for he first very carefully rectifies the deformity, which is usually neglected, and abandons the use of Splints. When he shall have gone a little further, and held the ulna up by the weight of the limb pressing it into its place, the method will be complete. I propose no general criticism of Dr. Roberts’ paper; the oft-quoted Saw about the play of Hamlet, with the Prince of Denmark left out, is strictly applicable to it. My first paper on this topic was a description of a single case, that of Mary Tumey, which drew my atten- tion to the subject in a new light. This paper was pub- lished in 1870, and read before the New York State Society. In it I made the statement that the displaced ulna, which had been observed in most cases by every surgeon, was really the displacement of luxation. Pº. Hamilton regarded this as merely producing a stra” INJURIES OF THE UPPER EXTREMITY. 495 upon the ligaments. Benjamin Bell said there was a dislocation, but founded his opinion upon the obvious displacement which every one recognises. Sir Astley Cooper, however, found the luxation by autopsy, and gave a plate of it, but his description is very meagre. My work is of a kind that I think has not been trav- ersed. My paper is upon “a luxation of the ulna not heretofore described.” Notwithstanding Cooper’s state- ment, I still think the claim is correct. Malgaigne also recognises a dislocation of the ulna in connection with Colles' fracture. He quotes Bouchat, who, in studying the luxation of the ulna upon the cadaver, found, as I have done, that the radius will usually break before the styloid process of the ulna gives way. My second paper was written in 1880, and read before the New York State Medical Society. In this paper Isay: It is now just ten years since I read a paper before this society upon “a luxation of the ulna not heretofore described.” The claim of originality in a matter of this kind, at this late day, was too great to be readily admitted, and it is a mild statement to say that it was received with incredulity. It will be recollected that my observation was founded on one case only, that of Mary Tumey, who sprang from a third-story window in a paroxySm of mania, and was instantly killed, making a few respirations for about twenty minutes. Both Wrists were broken, and the spine opposite the second and third dorsal vertebrae was crushed. The examina- tion of one wrist revealed, to my astonishment, the peculiar break and entanglement which I have described. Amazed at the result, which was not comprehended in its fullness at first, I proceeded to the dissection of the other wrist, and found precisely the same condition, with the exception of the line of fracture of the radius; one being nearly transverse, and the other quite oblique. The luxation of the ulna presented the same form of *Pure of the lateral ligament, from the styloid process, With the same entanglement of the annular ligament. 496 IVEW YORK STATE MEDICALL ASSOCIATION. To my report it has been replied that there have always existed irregular luxations that were not to be regarded as capable of classification. A regular luxation, so called, is one where the joint surface that is separated from its proper connections, is held in its abnormal but definite position, in obedience to definite forces. People. do not often spring from third-story windows, and this case, like the cause, is abnormal. This cavil, more specious than just, served to satisfy the conservative, and check further inquiry. The fract- ure of the radius close by the joint is one of the most common, and usually occurs from a fall upon the level ground, or from a step. This presents often very great, and heretofore insurmountable difficulties of restoration. Since the observation of the case of Mary Tumey, I have had far greater success in the management of these fract- ures, for I have relied upon the relation of the two con- ditions that I found in the autopsy of Mary Tumey, and that resulting from a fall on the level surface, as being similar, in consequence of the similarity of the appear- ance of the wrist. I, nevertheless, quite agree that We must not insist upon appearance, and diagnosis founded upon it, without proof from dissection. Now, patients do not die from the circumstance of falling over on the hand. The combination of circumstances that would destroy life, and leave us with a definite force of this kind, must recur at very remote intervals of time. Great violence must occur in the cases where we can get autopsies, although the force at the wrist might not be more than common in Colles’ fracture. The doctrine I have taught my classes for the last ten years may be succinctly stated. The fall comes upon the palm of the hand, and the radius which sustains the full force of the strain gives way at a point near the Wrist. The line of fracture is usually an oblique one, starting from a point on the anterior aspect of the radius, n° the articulation, and running backward and upward, making the posterior surface of the lower fragment INJURIES OF THE UPPER EXTREMITY. 497 longer than the anterior. It is seldom more than an inch from the joint, rarely so far. But the line of fracture is very various, sometimes simple and nearly transverse, but often comminuted to the last degree. The luxation of the ulna exists in more than half of the cases. I now feel quite sure, though I cannot demonstrate it by dis- section, that a proper observation of the relation of the head of the ulna to the carpus will make a just diagnosis of its luxation or non-luxation. The force of the fall may be just balanced by the strength of the radius, but in the nature of such accidents this would not often be the case. In most, there would be some force still to be borne. Upon what structures does this fall ? The radius instantly, on fracture, ceases to afford resistance, the hand is carried still further back, and then comes the strain on the attachments at the end of the ulna. It will be remembered that the ulna does not articulate with the wrist, but there is a distinct synovial cavity between its head and a strong membrane called the triangular fibro- cartilage. The membrane takes an origin from the rim and side of the radius, and covering the head of the ulna, is inserted in the pit at the root of the styloid process. As the hand, with its broken fragment of the radius, is forced backward, the strain is often sufficient to rupture the connection between the two bones or to break the ulna near the head. I have seen this double fracture twice only. The rupture takes place at the weakest point, which is its insertion in the pit at the root of the Styloid process. But this is not the Only resistance. The Styloid is held to the carpus by the internal lateral liga- ment, which takes a very firm hold upon the end and radial surface of the styloid. This also gives way, and usually does so in a peculiar manner—viz., by pulling off the surface of the bone, which proves to be weaker than the ligament. Thus the remaining styloid is brought to an edge like a gouge-chisel, and is shortened about one- half. When these resisting forces are disposed of, the end of the ulna, now laid bare, is pressed against the 32 498 NETW YORK STATE MEDICAL ASSOOIATION. posterior annular ligament, and is apt to become engaged upon it either by a fold, or, what is more likely, by splitting its fibres and hooking upon it. If very great violence has been used in the production of these lesions, the head of the ulna will be driven forward through the annular ligament and skin, thus producing a compound luxation. These opinions were urged by me upon the profession, chiefly in consequence of the autopsy of Mary Tumey, but also from the very greatly improved results of treatment founded on those views. But Iwaited for further proof with no little impatience. The next case that goes to confirm the views I have brought forward, was one that proved the luxation by thrusting the head of the ulna through the skin. I report the case: - John O’Hara, forty years of age, a laborer in a lumber yard, fell from a lumber pile eleven feet high, striking with his outstretched hand on a plank roadway. The force was so great as to break the radius just above the wrist, also at its middle, and to dislocate it forward at the elbow. As might be supposed, the radius was much shortened. The ulna was freed from its attachments, as has been described, and pushed through the skin. In this condition the case was presented to me. I removed the end of the ulna with a saw, dressed the fracture, and reduced the luxation at the elbow. The patient made a slow recovery, but finally obtained very good use of the arm. This bone I now present. Fig. 1. FIG. 1–1, Styloid shortened by fracture; 2, tags of triangular *. cartilage at the root of the styloid; 3, smooth articulating surface at the end of the ulna. INJURIES OF THE UPPER EXTREMITY. 499 It is absolutely as first found. This adds another, now the third case, where the triangular fibro-cartilage and lateral ligament were torn off in precisely the same man- ner; the two in Mary Tumey being only engaged in a rupture of the posterior annular ligament and skin. But it will be remembered that the two in Tumey’s case were only accompanied with the ordinary fracture of the radius at the lower end, and Only one fracture in each arm. Where the luxation of the ulna was compound, the radius was enormously shortened by two fractures and luxation at the elbow. A case like O’Hara's has the full value of an autopsy, for the end of the ulna is in our hands, and the fracture can be diagnosticated without failure. I think, in view of the fact that the fractures in the case of Tumey were only of the ordinary character of those styled Colles', with a good deal of the peculiar deformity, that the mode of luxation found here may be fairly concluded to occur from apparently slighter forces, but which are suf- ficient to break the bone. But I now present you a specimen which, in a singular Way, leaves no chance for argument or cavil with refer- ence to the ability of the apparently moderate force to produce the luxation I describe. I am indebted for this to my friend, Dr. Thos. Collins, of Rochester, who was called to see a farmer, who, attempting to get out of his Wagon, Slipped from the hub, falling upon his hand. pon examination, the radius was found to be broken, and the ulna was protruded through the skin. An attempt Was made to reduce the luxation, but to his sur- prise and that of his counsel, Dr. J. F. Whitbeck, it was found impossible to reduce it. Therefore it was sawed of and the fracture dressed. (I might add at this point that he made a good recovery, acquiring as good use of the arm as before the latter accident.) I now present this specimen. Upon inspection, it will be seen that it presents a very extraordinary appearance. The shaft of the ulna is apparent, but the side and part 500 NEW YORK STATE MEDICAL ASSOCIATION. of the end is covered with as fine a specimen of eburna- tion as it is possible to produce. The extremity of the ulna exhibits, instead of a smooth articulating surface, a rough one, made up of ruptured tags of cicatricial tissue. FIG. 2.-1, End of ulna, sawed surface : 2, crust of eburnated bone. FIG. 3.−1, Styloid short and smooth, rounded by time ; 2, tags of mem- brane attached to and obliterating articular surface; 3, crust of eburnated bone. Inquiry revealed the fact of an antecedent fracture of the radius sixteen years before. The case, as rendered by Dr. Collins, is as follows: Jacob Winslow, seventy-five years of age, received the injury as above described, October 25, 1873. In the year 1857, while walking in a saw-mill yard, he stepped on a slab and fell over on his hand, producing Colles' fracture. The mode of treat- ment at this time is unknown. There can be but one inference from this case. We have, by the complete disappearance of the articulating surface, unmistakable proof of antecedent luxation. The eburnation also shows the effect of long and severe friction upon the side, the result of the severe and pro- tracted labor of a farmer's life. The return of the luxa- tion was attempted, but in vain, in consequence of the extreme projection of the ulna, due to the antecedent accident. Several years elapsed without further proof derived from autopsy. But another case, resembling Mary Tumey's, occurred on the 11th of October, 1879. Morris Huntington, fifty-six years of age, a painter, fell from the roof of a three-story house, through a tree, to the side-walk. He was at once taken to the City IWJURIES OF THE UPPER EXTREMITY. 501 Hospital, but only lived a few hours. A fracture of the wrist was observed, but he was so nearly moribund that it was not interfered with. I was invited, by the kind- ness of the staff, to make the autopsy. This was done by simply removing the skin from the posterior surface of the wrist, extending to the sides, thus coming at Once upon the annular ligament. The end of the styloid chisel protruded through a rent in the ligament. This was carefully touched by Drs. Whitbeck, Montgomery, Little, Langworthy, Ely, Mallory and others. It was precisely, in all its details, as before observed, and as I described it ten years since. The next move in the dissection was the removal of the skin on the anterior aspect of the arm, and the di- vision of the muscles and tendons down to the bones. These were then lifted up just far enough to see the end : --> -: S >: N É = : F S = S º:* : : - . … * it S º: : ; : S - *. º 2: ; : S → S º : . - * * E N § : B. - : S = N - & #. E : : S > S - ------- : : tº: : S = S ," ſº º B - E. S. $P S ** º: *:::: #: -- Ss. - N s: --- ~ * - > S > S •º …; E = E= ± = E: S3- S §§ ÉÉ, #### = $S § - = ###, S㺠= <= Sº S § : E.: E > S S sº : -* -> E - Sº S º Śā --- E - sº S : &: -: E--> * Š à. §: NS . º::=. y N Assis A. . º Tº $ $ S$ 2 ºf is sº º S plmſ º' W . ºf . , sº . SS - Ø 4. *ss, . . ; º *~ § th f º §§ * * º ºsºs awm ... ºn Sº §§ ; :"º * - M. N. B. In both fi Fig. 4. gures the hand is uppermost. —Posterior aspect of wrist.—1, wrist-joint; 2, comminuted frag- *ents of the end of the radius ; 3, shaft of the radius; 4, styloid process of ulna, pricking through the an Fig. 5.—Anterior aspect of w lage, unusually long ; nular ligament. rist.—1, tag of the triangular fibro-carti- 2, articulating surface of the head of the ulna. 502 NEW YORK STATE MEDICAL ASSOCIATION. of the ulna. The triangular fibro-cartilage was torn out at the pit of the styloid, and the internal lateral liga- ment torn off with the end of the styloid, as in the other cases. I now present you this specimen in its wet state. The rent and luxation can be seen, and the styloid chisel is almost precisely the same in shape as that of O'Hara's. This case confirms all previous observations. It would not unlikely have been a compound luxation, but for the fact that the ulna was broken about three inches from the wrist, for the radius presents a condition of extraor- dinary comminution. Luxations of the ulna have been noted heretofore, but they have been regarded as irregular, and as having no definite character. In the discussion upon this topic at the meeting of the American Medical Association, held at Buffalo, I took the ground that for every compound luxation of any joint we will have a large number of simple ones. In the absence of statistics, which are not possible, I asseverated the round number of fifty. I repeat it on the ground that it could not be an exception to all our observations of other joints. A distinguished author replies that this could not be said of dislocation of the astragalus. But I rejoin that there is no analogy. The only analogue of the tarsus is the carpus. The ulna is a long bone, and must find its analogue among the long bones. It requires very great violence to pro- duce a compound luxation at any place. Less force produces the simple luxation, and this we have Very often with Colles’ fracture. Thus far my paper has referred only to the evidence bearing on the question of the existence of luxation of the ulna at the lower end—evidence that is purely demonstrative and beyond the reach of argument. But I feel justified in adding some inferences of observation on the living subject. In my previous paper I called attention to the position of the tendon of the extenso" carpi ulnaris. It runs alongside of the head of the ulna and behind the styloid. When the luxation does not IWJURIES OF THE UPPER EXTREMITY. 503 exist and the fracture does, the head of the bone main- tains its relation with the tendon but little disturbed. When, however, the luxation does occur, the tendon will appear to lie over the head. I feel quite sure that this does not result from any twist of the hand carrying the fragment of the radius. The dead tissue presents the tendon curved out of its place. In the living, under muscular contraction, this would be a straight line and lie over the head of the ulna. I find also, in what I deem cases of luxation, a mobility of the end of the ulna incompatible with the integrity of the ligamentous appa- ratus. Every observer has recognised a difference of the form of the wrist in different cases. Some are curved backward—the genuine silver-fork shape; others have the hand carried more laterally. My convictions are that those that present the wrist well curved back are more apt to be those of luxation of the ulna with fract- ure, but the lateral bend implies generally shortening of the radius from fracture without luxation of the ulna. In my previous paper I proposed a form of traction and circumduction which is intended to disentangle the ulna and carry it up in its place between the tendons of the extensor carpi ulnaris and extensor minimi digiti. I by no means wish to say that this is always necessary, for the great point should be not to relax any effort until Complete restoration has taken place. The gentle hand- ling that is ordinarily employed in the management of the fracture is out of place here. Great force is often necessary to restore the symmetry of the parts. We must keep in mind that a luxation is to be reduced, and should not cease our traction until the end is attained. Besides, the muscles will produce consecutive luxation instantly if the parts are not held firmly until the dress- ing is complete. a:ºx-tº-5- L-zºt Fis - | # , , \ 2. , Wºlf h" ſº liff ſh ºſmºs ;"| º - iſſiſſiri mrmy FIG. 6.—Position of roller compress. 504 NEW YORK STATE MEDICAL ASSOCIATION. I find, as a rule, that a strong pull, with the head of the ulna resting against my knee, and the hand of the patient curved downward is sufficient to bring the bones into their proper place. But it requires great force in some cases. Effort at the rectification of the luxation and fracture should not be abandoned until the end is attained. If the fracture is simple and transverse, it is usually retained in its place with ease, but if it be com- minuted or even oblique, displacement is apt to occur at once. Therefore the dressing should be completed before any relaxation of the retentive apparatus is allowed. - With the thumb of the surgeon under the ulna, the hand beneath, and the fingers upon the back of the wrist holding with great firmness, I apply my dressing. This, it will be remembered, consists of a simple roller from half to three-quarters of an inch in diameter and two inches long. This is to be carefully placed under the ulna, abutting against the pisiform bone and slowly dis- placing the thumb. Then a strip of adhesive plaster of FIG. 7.-Roller, with adhesive strap applied. the same width is drawn, with as much force as it will bear, around the wrist and pinned to prevent relaxation. The band of plastered cloth is carefully adjusted so that the distal edge is brought around on a line with the end of the radius. It is manifest that this bandage will grasp the broken fragment, and hold it to the end of the ulna. The rule, of loose dressing at first, is distinctly violated for a purpose. I repeat that I draw it as firmly as I can, often breaking the plaster cloth. The dressing is entirely completed by the use of a sling which must not be more than three inches wide. This must be placed over the roller, and is made of this width to Cause INJURIES OF THE UPPER EXTREMITY. 505. the whole bearing to come on the roller, which is both compress and splint. The hand is brought down and allowed to hang naturally. Thus its weight and that of the forearm is used to press the ulna upward into its proper place. If all this is successfully accomplished, the broken fragments of the radius are easily kept in place. The full length of the arm is maintained if the ulna does not fall down, and the tendons that run over the back of the wrist are so closely parallel as to make the best possible splint. I do not continue so gross a viola- tion of the primary rule in dressing fractures, as to retain the bandage in its tight condition ; but, after six hours, cut it by thrusting one blade of a pair of scissors FIG. 8.-Colles' fracture; dressing complete. inder it on the back of the wrist, dividing it completely. * few hours of such retention seem to be sufficient. The meagreness of the appliance has startled some Who have attempted its use. But any addition that I *Wºmade has injured it. I find there is a strong dis- Pºsition on the part of the patient to lift up the hand 606 NEW YORK STATE MEDICAL ASSOOIATION. with the sound one. With unintelligent patients this is often troublesome, and a splint of thin iron, such as hoop iron, bent so as to come over the back of the wrist and hand, and bound upon the forearm but not upon the hand, will guard against this error. I am careful not to bind the hand to it, for I desire the constant action of gravity. The position can be maintained, even in the recumbent posture. The slight motion in the joint which will necessarily be produced by allowing it to hang freely, prevents the stiffness that is so often a very seri- ous inconvenience after the treatment of this fracture. There is another question to be answered: How good are the results & My experience has been considerable, as my professional brethren have shown me their cases when treated after my method. When there is much comminution there will be some absorption of the bone. This will produce a slight deflection. But if the fracture is transverse, deformity can hardly be said to exist. As in other luxations, the union of the ligaments is apt to result in their elongation, making, when the cure is per- fected, a certain laxity and mobility of the head of the ulna after the fracture is perfectly firm. When the fracture is transverse, I have removed the bandage at the end of two weeks, but in other cases the treatment has been extended to four weeks. I would remark that the reputation of the pistol-shaped splint, Bond's, Levis’s, and most others, can be explained. If great pains is taken to restore the parts, the flexed posi- tion of the hand will have a tendency to keep the restored ulna in place, especially if suitable compresses are used. These can be well adjusted in Bond's and Levis’s splints. Moreover, in those cases in which there is no luxation, the results are apt to be good in the fixed position, for the full length is obtained because the ulna is not dis- turbed. Where luxation occurs, the muscles have a Con- stant tendency to displace the ulnar head, which, when slipped downward in the least, is apt to remain. I there. fore prefer gravity to any fixed splint ; for the Comº INJURIES OF THE UPPER EXTREMITY. 507 presses, even if applied tightly, will yield, and any relax- ation of the retentive force is apt to be accompanied with displacement. Moreover, by my simple dressing, the parts are under view without its derangement. I would urge the profession to banish the fear of its use as leading to disaster, with the full conviction, founded on the experience of my friends, that once understood and practiced, no other would be thought of. Since this paper was written, my observation has been extended. I have refractured many forearms brought to me by medical men. I never hesitate in this matter, and do not recollect a single case in which there was any cause for regret. Those that have remained displaced are usually such as have been retained in their mal- position by the splints. Great stiffness and pain are the common results, with the fingers so fixed as to give the hand the appearance of a claw. When the luxation and fracture have been reduced immediately after the accident, the pain rapidly disappears as a result of the rectification. The suffering so often witnessed in those who have this fracture, is due to displacement; indeed I have never Seen it occur in cases that were properly rectified. But When after a continuance of the erroneous position for a few months the refracture is made, it does not relieve the pain at once; on the contrary, it is aggravated for a time in consequence of the new traumatism. After reduction of the fracture and the accompanying luxation in recent cases, I trust to the weight of the hand, which naturally hangs down, to retain the frag- ºnents of bone in their place. For this purpose no splint “an be devised so well fitted as the tendons which run 9Wer the back of the wrist. But when the hand has been thrown back for a period of weeks or months, its *ght is not sufficient to cause it to hang down. This Position of the hand is necessary to assure the carrying Of the head of the ulna up into its place. I therefore strap into the palm of the hand a pound of shot, having, While the patient is under ether, bent the hand well 508 NEW YORK STATE MEDICAL ASSOCIATION. down. At the end of two days there will be no tendency on the part of the hand to rise, and the weight may be removed. The question has been asked if stiffness of the fingers and wrist occur, with this method of treat- ment. The answer is definite—it does not. When they are not confined by splints, they will be moved, and in consequence of these movements the wrist and fingers will have a gentle, passive motion. The time necessary for treatment is only about half of that which is usually employed—two or three weeks in recent cases, and four or five in refractures. If the bone be comminuted, I advise a longer period of treatment. I have again broken the lower end of the radius more than six months after the original fracture ; indeed I have treated one in this manner that was fractured three years before, and with much benefit. But the absorption of bone so shortens the radius that the deformity is not relieved. I there- fore make it a rule not to operate in this manner more than six months after the injury. • A great many cases can be improved by another Opera- tion. On measurement it will be found that most of them present half an inch shortening of the radius. This is easily made out by using an ordinary carpenter's square, placing the arm and forearm upon it so that the elbow is in its angle. The styloid processes of the ulna and the radius should be opposite each other, and the difference when there is a fracture can be easily read by this method. - - There is also another kind of deformity at the point of injury. The breadth of the forearm is increased by one- fourth or one-third of an inch. In consequence of the shortening of the radius the ulna is pressed forward and downward against the side of the wrist when it is lux- ated. This usually gives rise to great pain. It is also asserted that a nerve filament is rendered tense. By re- secting the end of the ulna and removing half an inch the bone is made of the same length as the radius. ! know of but two cases that have been thus treated, and INJURIES OF THE UPPER EXTREMITY. 509 both with charming results. One was by my own hands and the other by another surgeon by my advice. The operation should have a wide application until better methods of primary treatment are more general. It will be recollected that I have stated that the inju- ries known as Colles’ fracture may be, as Professor Colles states, confined to a break of the radius; but my belief is that the connections of the ulna are usually rup- tured as above described, so that its head and styloid process press against the posterior annular ligament. If the unexpended force be a little greater than in such a case, the ligament becomes ruptured by the point of the styloid, or has even the whole head thrust through it. If the radius be broken in another place at the same time, or if it be dislocated at the elbow, it may be so shortened as to allow the head of the ulna to go through the skin. These opinions are the result of a careful study of cases by autopsy. I have expected when making such examinations to find some of them presenting a simple fracture, but this has never been my lot. Professor McGraw cites an autopsy of this kind. But in several cases Ihave found the triangular fibro-cartilage ruptured, and in six of the cases the internal lateral ligament was torn off. After reduction the treatment that holds the head of the ulna up in its place is applicable to all these forms of injury, for it places an unbroken parallel bone in its proper relation to the wrist. I find the attachments to the ulna are less likely to be ruptured in hard-working men than in persons who do not labor. I refractured a radius that had been broken at this place in a laborer While the ulna was still in its normal position. He was disabled by the pain from displacement, but the opera- tion gave complete relief. I cannot close my paper without speaking of my method of dressing the phalanges when they are broken. Most authors seem to consider these fractures insignifi- *t, but this is not my opinion. The great value of the fingers to Workingmen, and perforce to all men, should 510 NEW YORK STATE MEDICAL ASSOCIATION. make us careful to Secure exact apposition, and to use the neatest Surgical appliances. The usual custom is to dress these fractures with straight splints of wood, thus carrying the fingers out in a straight line. This puts the flexor tendons on the stretch, which will of itself cause the passing of fragments and interfere with proper mo- tions of the joints. I have for a long time dressed all these injuries in the semi-flexed position, which relaxes the strong flexors. The retentive apparatus should also bear a proper rela- tion to the size of the member to be treated. For this purpose I employ upon the broken phalanges a strip of tin half an inch wide, bent to correspond to the joint so as to make a close fit and give perfect support. In bandaging, a broad strip of either cloth or adhesive plaster is inappropriate. Adhesive plaster should be cut into strips less than a quarter of an inch in width, and these should be wound straight around the finger and splint, lapping over each other for one-half of their width. This plan provides for smoothness without re- verse turns. The end of the finger should be held by an assistant and drawn upon so as to get its full length. The bandaging should vary from the surgical rule and should be applied firmly for a few hours, or even for the first day, after which it may be split down by inserting the blade of a pair of scissors under it and cutting through its whole length. The adhesion of the plaster is sufficient to retain it, and any swelling is relieved by its sliding over the surface. It is particularly in compound fractures that We See remarkable results from antiseptic surgery. Ithink one of its most striking and generally useful applications is in the repair of a hand torn in pieces by machinery. Formerly the mode of dressing I have described Was applicable to cases where the hand was so injured. The parts would be brought together and poultices applied, if the bandage of adhesive plaster was not cut ; but sloughing and necrosis were common, and often after INJURIES OF THE UPPER EXTREMITY. 511 much delay amputation became necessary. Now, with clean hands we devote half an hour or more to Searching out with the nail brush and Soap and water the minutest speck in the creases of the begrimed skin and wounded tissue, after which we apply our antiseptic, and at last stitch the torn tendons and nerves. The theoa is sutured over the tendons, and the skin over all. A proper dress- ing is now applied, and usually no splinting is required, the united tendons causing the fingers to take the Semi- flexed position. But it may be necessary to add splint- ing. The plan I have proposed may be rendered as anti- septic as any of the other dressings. The tin may be. most thoroughly purified by passing it through the flame of an alcohol lamp, and the strips of adhesive plaster can also be rendered aseptic by the same method, and still not destroyed. FRACTURE OF THE PATELLA TREATED BY CONTINUOUS EXTENSION: PATIENTS NOT CONFINED TO BED. By Jose,PH. D. BRYANT, M. D., of New York County. JNovember 16, 1892. Two varieties of treatment of fractured patella are generally recognised, the mechanical and the operative. It is not my intention to allude to the latter method, except in a general way; nor, in fact, to the devices of the former plan except as they may be employed to illustrate the method of treatment that I present. The indications to be met in the treatment of this fracture are the stereotyped ones that are applicable to all fract- ures, namely, the reduction of the fragments and the holding of them in place until a proper degree of union ensues to permit of the removal of the retaining forces. In fracture of the patella the uppermost fragment is drawn upward by the influence of the quadriceps extensor muscle, while the lower is somewhat displaced downward by means of the non-muscular tissues attached to it. Ordinarily, crepitus can be easily elicited between the fragments, provided the attempt be made before the for- mation of the firm blood-clots that become closely con- nected with the broken surface of the bone within a few hours after fracture. The failure of the medical attend- ant to obtain crepitus at this time should be attributed to the presence of these clots rather than to the influence of the stretched aponeurotic tissues connected with the upper surface of the patella. The presence of these clots and their influence in separating the fragments are frequently and easily demonstrated during the operative technique of wiring the patella for fracture. FRACTURE OF THE PATELLA. 513 The steps necessary for the reduction are, first, the extension of the leg and the elevation of the limb to secure complete relaxation of the quadriceps extensor muscle ; second, the drawing together and retention of the fragments in position until some form of union insures sufficient strength to properly maintain them in place. It is hardly necessary for me to describe the various instrumental means heretofore employed to effect the reduction and retention of the fragments in this fracture. It is sufficient to say, however, that their basis-action consists in extension applied directly or indirectly to the upper fragment, and the holding of the lower fragment upward in position. The extension is represented in these cases as applied to the upper frag- ment and to the thigh, and also to both of these parts simultaneously. It is manifest to one familiar with the relationship of the tissues composing the thigh, that extension applied to the thigh alone can exercise but little other restraining influence on muscular contraction than that dependent on coaptation pressure, because the dense fascia lata intervenes between the muscles of the thigh and the integument to which the extension is ap- plied. However, when extension-apparatus is applied to the upper fragment of the patella with sufficient firmness to meet the indication, then, indeed, some command of the quadriceps muscle is secured. But even in this instance the inequality, severity, and direction of the pressure necessarily brought against this fragment, together with the absorption of the surrounding soft parts incident to the pressure, quickly render its influence insecure and migratory, unless constant and tedious, not to Say painful attention be given to the case. In my judgment, the feature most commendable in the Wiring method is this: It permits patients to move around on crutches within a few days, thereby relieving them of the tedium and depression of long confinement. Of the mechanical appliances permitting patients to be at Once about on crutches, plaster-of-Paris, applied in 33 514 NEW YORK STATE MEDICAL ASSOCIATION. the form of a thigh or hip spica, extending down to cover the foot, with an oblique patella-traction arrange- ment of the bandage at the knee, is most often selected. With this method, even in a very few days, the limited direct-extension influence that the splint exercises on the upper fragment disappears, owing to the shrinkage of the limb, and in part to the pressure of the splint itself. The coaptation-influence on the tissues of the thigh, exercised by the splint at the time of its applica- tion, is soon much lessened on account of the same shrinkage. I have quite often witnessed the treatment of this fracture with the plaster-of-Paris splint when little attention was paid to the tissue-changes following its application, even up to final recovery ; and candor compels me to state that in these cases the results were quite as satisfactory in all respects as in cases treated more actively and with seemingly better philosophy. I have often remarked that the results of the treatment of fracture of the patella with a plaster-of-Paris spica were much more convincing of the fact of how little treatment the fracture required than of the efficiency of this par- ticular method. However this may be, it is surely a great desideratum to employ a means that, while it holds the fragments as well as possible by mechanical meas- ures, still subjects the patient to as little confinement as if wiring of the patella had been done. The plan that I have employed with some interruptions, for a number of years past, can be divided for the sake of simple elucida- tion into five separate steps. A'irst step. The first step consists in the application to the leg of a plaster-of-Paris splint, extending from the base of the toes up to and partly around the lower fragment. The splint is firmly applied to the limb a sufficient time in advance of the succeeding steps to permit of its becoming thoroughly hardened. It is care- fully rounded at the lower extremity, so as to press into position and hold there the lower fragment. Its func- tions can be said to be threefold: 1st. It serves to protect FRAOTURE OF THE PATELLA. 515 the foot of the patient from the pressure of the rubber extension, which acts from this part of the limb. 2d. It confines in place the lower fragment, and the pressure upward of the splint due to the elastic force of the extension transmitted through it to the foot, retains the upper border of the splint in proper relationship to the lower fragment. At all events, any diminution of pres- sure on the part of the splint in this situation can be readily supplemented by the introduction of suitable pads between it and the lower fragment of the patella. 3d. It affords attachment to the lower end of the sup- porting rod or brace, intended to maintain complete extension of the limb while acting as a posterior support. Second step. The features of the second step are quite as strongly expressed by the illustration representing it as words can define them." This step consists in the application to the thigh of an extension-apparatus fash- ioned after the manner of the well-known Buck’s exten- sion, which reaches from the perinaeum to the upper border of the upper fragment. It is confined in position by the ordinary muslin roller. The adhesive element of this appliance terminates a little below the knee in a loop at either side, through which may be passed the rubber extending cord, or to which may be connected hooks for the convenient attachment of the rubber cords or bands that are to pass around the bottom of the splint, and by means of which the extension is made and maintained. The broad, triangular adhesive Strips to which the extension loops are sewed are con- fined in position at the sides of the thigh by means of simple roller bandages. Moderate extension is then made on the loops by means of the rubber cords, in order to draw as far as possible downward the soft tissues of the thigh and the upper fragment of the patella. While the extension is thus being made, the roller bandage intended to hold the adhesive plaster strips in place is CoVered by plaster-of-Paris rollers from the upper to the * Illustrations not reproduced.—ED. 516 NEW YORK STATE MEDICAL ASSOOIATION. lower limits of the adhesive plaster extension, and so fashioned as to control the upper fragment in the most serviceable manner while extension is in action. The object of this plaster-of-Paris addendum is, first, to aid in holding the primary dressing of the thigh in a firm position ; Second, and principally, to afford an upper Support for the extending rod or splint to be placed behind the limb, and to aid, also, in confining the upper fragment of the bone in proper relationship to its fellow, as will appear in the succeeding step. The second step meets the following indications: First, it coaptates the tissues of the thigh, thereby exercising a controlling influence over muscular contraction, and is the agent causing extension of the integument and the subcutaneous tissue. Second, it makes direct extension of the quadriceps through its firm application to the upper fragment of the fractured bone and the tissues immediately above and around it. Third step. This step consists in strapping the frag- ments of the patella in such a manner as to draw them well together and properly maintain them in position. These strips of plaster are fastened in position behind to a wooden support or brace, about two inches in width, one inch in thickness, and extending from near the upper border of the thigh portion of the splint to the lower part of the splint surrounding the leg. These adhesive strips should be applied cautiously, so as not to irritate the integument, and also to prevent either of them from being drawn downward between the fragments of the broken bone. If this accident happens, greater separation of the fragments ensues, and union of a Ser- viceable kind is much delayed, and may be defeated. These strips can be applied with greater care, Conven- ience, and effectiveness, if traction be made away from the median line of the thigh. - Fourth step. This consists in fastening the posterior support or brace in proper position, and fixing it there by means of plaster-of-Paris rollers carried around it and FRACTURE OF THE PATELLA. 517 the upper and lower segments of the splint where they lie in contact with each other. These bandages harden quickly, and thus incorporate the posterior support firm- ly with their structure, forming an interrupted plaster- of-Paris splint, with a posterior connecting brace. Fifth step. The posterior support in the illustration' is unusually thick, being composed of wood. A Small iron rod on each side of the posterior surface of the limb will answer much better for many reasons, and is less cumbersome. The posterior support should be placed against the posterior surfaces of the plaster splints pre- viously described, and confined there by fresh plaster rollers while the extension force is in action. These band- ages are represented as carried around the limb from the extremities of the support to the contiguous borders of the underlying plaster splints. As already mentioned, the hardening of these newly applied bandages incor- porates the posterior support with the plaster-of-Paris Structure so firmly that an unyielding common apparatus is formed. The object of this support is obvious to any One. It serves to keep the limb extended, thus prevent- ing undue traction on the fragment of the quadriceps muscle, and it affords attachment to the adhesive plasters that confine the fragments of the patella in proper position. Leather collars, properly fashioned and padded, passing around the limb above and below the patella, and drawn firmly toward each other by means of leather straps, as figured in the text-books, may be employed instead of this method of strapping. In either instance the hamstring tendons should be carefully pro- tected from undue pressure by the interposition of some soft suitable material. After the apparatus is completely and suitably applied, the patient may be permitted to Walk around, but the limb during this time should be flexed somewhat on the trunk by means of a long sling extending from the foot, which it supports, and carried 9Ver the neck of the patient. The employment of this * Not reproduced. 518 NEW YORK STATE MEDICAL ASSOCIATION. expedient will flex the entire limb considerably on the trunk, and thereby cause greater relaxation of the Quadriceps extensor muscle, and also obviate the in- fluence on the upper fragment of the involuntary con- traction of the muscles that are associated in the effort of locomotion. TIII. ADVANTAGES OF THIS APPLIANO.E. The following advantages appear to me to be quite clearly defined : . 1. It apposes the fragments of the patella from the first as well as any other non-operative appliance can accomplish this purpose. 2. It maintains them in position better than any mechanical means yet employed, unless the patient be confined in bed and a constant and tedious scrutiny be exercised by the physician in charge. 3. It permits the patient to be up and around sooner and more comfortably than any non-operative method of treatment yet employed. I have thus far treated nine cases by this method, with results equal to those of any other non-operative method, and with much more comfort to the patients. Like all methods, this one, too, has its fallacies. It is important to regulate the degree of elastic extension in accordance with the requirements of each particular case. If greater extension be employed than is essential, the straps by means of which the extension is secured may be torn Or drawn away from their fastenings. At all events, great discomfort will be caused. It is proper to say, however, that a degree of extension may be employed which will be readily withstood by the straps at the earlier period of their application, which is out of all proportion to the requirements of the case, and at a later period would promptly cause slipping of the adhesive straps. In One instance, as a matter of experiment alone, I applied a degree of elastic traction to a case equivalent to forty FRACTURE OF THE PATELLA. 519 pounds. It may be thought, perhaps, that the applica- tion around the thigh of the plaster-of-Paris casing, and introduction of the posterior support connecting the two portions of the splint, will interfere with the extension influence applied to the thigh itself. This, however, is not the case, as the extension acts independently of the incasing plaster, while at the same time the incasing plaster serves to confine the adhesive strips properly in position. If the interval between the plaster splints corresponding to the knee and popliteal space be not thoroughly and carefully covered, either with straps, cotton, or bandages, pain and Oedema will, for obvious reasons, take place there. After the adhesive strips are properly applied to the patella, the intervals between the splints, behind and in front, should be filled in with layers of absorbent or other kind of cotton, and bandaged closely in place. At the time the posterior support is placed in position, cot- ton or other suitable material for exercising moderate pressure should be interposed between it and the pos- terior surface of the knee, before the patella-retaining straps are applied, as then this material can be drawn firmly into place. As before remarked, the fragments should be carefully and properly strapped, and great Care exercised in the application of the straps, else one of them may be drawn between the fragments, and before its discovery may cause greater separation and interfere with the union. * Finally, it is necessary that the plaster splints should be kept firmly apposed to the underlying surfaces, Which, of course necessitates their being cut up quite Soon after their application. The cutting up can be easily done by means of an ordinary knife after the manner usually employed in other forms of splints of a similar nature. If a proper portion of the splint be removed in the line of incision, the splint can then be firmly drawn in place around the limb by means of an ordinary mus- lin roller. 520 NEW YORK STATE MEDICAL ASSOCIATION. In presenting to your consideration this method of treatment of fractures of the patella, I do not claim any originality as to the application of extending force in this manner to the thigh, as I recall distinctly having seen, while an interne in Bellevue Hospital in 1870, a similar extension applied to the thigh for fracture of the patella by Dr. Stephen Smith. However, in that in- stance the patient was kept in bed, and no effort was made to control the lower fragment by means of a plaster splint or by the influence of the extension employed in making traction upon the upper fragment. I have not, however, as yet seen or learned of the treatment of fracture of the patella by a method in any way con- templating the use of extending influence associated only with the limb itself, the introduction of a posterior stiffening Support, and non-confinement of the patient in bed. WINTER CHOLERA IN POUGHKEEPSIE. By JAMEs G. PortEous, M. D., of Dutchess County. (Read by title November 17, 1892.) For twelve years, and an uncertain period before that time, there has been in Poughkeepsie, an epidemic of diarrhoea, which both the medical profession and laity are accustomed to call Winter Cholera. It usually begins in December and lasts into March with varying intensity, and is much more severe in cold weather ; but even in a warm open winter like that of 1889–90, it prevailed to a moderate extent. Last winter it appeared to be more Severe and widespread than formerly. An attack of winter cholera usually begins with slight nausea, at times accompanied by chilly sensations, more or less pain in head, back, and extremities, thin grayish discharges from the bowels, occurring, in severe cases, as often as every half hour. If unchecked it soon takes on a flaky appearance, is not unfrequently tinged With blood, and is attended with considerable pain in the bowels, just before and during an evacuation. There is often slight general tenderness over the abdomen, and Sometimes moderate tympanites. The temperature does not often rise above 101° or 102° F. ; the tongue is Coated with a white or yellowish fur; the pulse is rather Small and rapid, and there is an almost entire loss of ap- petite. When uncomplicated, recovery ensues, but it is often tedious, and the disease is prone to recur. The pathological condition is as yet unknown. Non-residents, as a rule, are much more susceptible to the disease than residents of the city. A few years ago, during a Convention, numbering about two hundred, I should judge that over one-half of the delegates were affected by the disease. 622 NEW YORK STATE MEDICAL ASSOCIATION. Winter cholera, as a rule, is readily checked by small doses of mercurial chalk, and some opiate, as Tully pow- der, but is very likely to return ; astringents do not con- trol it very well. The principal point of interest in a disease like this, which causes a great deal of suffering and loss of time, is its cause. My own opinion is, that the cause lies en- tirely in the city water. Many of the physicians in Poughkeepsie deny this, though I have never known them to assign any other cause. The water supplied to Poughkeepsie is taken from the Hudson River, 28,000 feet above the outlet of the city sewers, and 18,000 feet below the outlet of the sewer from the Hudson River State Hospital for the Insane. The city has about twenty-three thousand inhabitants, and a number of factories, and the insane asylum has over five hundred inmates. The pumping station for the water works is on the same side of the river as the city and asylum, and being between their sewers, whichever way the tide is running, sewage is likely to be carried to the intake pipe, which takes the water from under, and about four feet inside the face of the dock used to land coal. From here it is pumped into the filter-beds, where it is passed through two feet of sand, eighteen inches of gravel, and two feet six inches of broken Stones. - Notwithstanding the enormous growth of algae in the filter-beds in the summer, this filtering, aided by the vegetable growths in the river, and the action of the Sun and air, appears to purify the water sufficiently to pre- vent disease; but as soon as the ice forms in the river and filter-beds, winter cholera invariably begins. The proof that it is the river water rests almost entirely on clinical facts; bacteriological and chemical examina- tions do not positively account for it. In reply to an inquiry addressed to H. Lyle Smith, Health Officer of Hudson, he says of that city: “Winter cholera prevails regularly, beginning in January and continuing until WINTER CHOLERA IN POUGHREEPSIE. 523 spring. There is no doubt in my mind that the cause lies in the river supply, as it was an unknown factor in our disease list before the river water was introduced.” Dr. Joseph D. Craig, of Albany, in an address read before the Medical Society of the County of Albany, speaking of the use of river water contaminated by sewage, SayS: “The Schenectady type of diarrhoea began about the first of December, and continued till about the middle of March. Furthermore, rivers contaminated with sewage and covered with ice, are more dangerous as sources of water supply, through insufficient ačration of the con- tained water, than when open. “Among men engaged as boatmen during the Summer, and as ice-cutters during the winter, and drinking river water at all seasons, it was distinctly observed that such men were free from diarrhoeal disease in the summer, but were largely affected in the winter.” The winter cholera or diarrhoea of Poughkeepsie is Of the same severe type described by Dr. Craig, as caused by the use of river water at Schenectady, Cohoes, Albany, and West Troy. During the winter of 1890, a young lady from one of the towns of Dutchess County came to Poughkeepsie for the winter. In a short time she was attacked by winter Cholera, and for four days was treated by the usual remedies, but grew constantly worse, until the evacua- tions reached an average of two each hour during twenty- four hours. These discharges were thin, offensive, and tinged with blood. During these four days she was allowed to drink city water; then I sent water from a cistern at my house, and this was used for her drink and In preparing her food. During the first twenty-four hours the diarrhoea was very much diminished, during the second twenty-four hours medicine for the diarrhoea Was Omitted, but cistern water continued, and at the end of that time the diarrhoea had ceased. During the entire Winter two days' use of the city water would bring a 524 NEW YORK STATE MEDICAL ASSOCIATION. return of diarrhoea, which would as promptly cease on leaving it off. A gentleman and his wife came to Poughkeepsie for the holidays, taking their daughter from Wassar College to a hotel in town. The second day all three were down with violent diarrhoea, but a change of water promptly relieved them. The daughter had not suffered from diarrhoea at the college before, the water there being taken from a Spring. During about four years that I was consulting physi- cian at Vassar College, I never knew of a case of winter cholera which could not be traced to the use of city water, although the college is less than two miles from the city. One morning last winter, a whole family, mother, two daughters, nurse, and servants, were taken ill the same morning. They stated that they did not use city water for drinking or cooking, but on inquiry, it was learned that for two days the cistern pump had been frozen, and they had used the city water. A return to the cistern water relieved them promptly. A strong, active mason called me for a severe attack of winter cholera. I gave him three or four Tully's powders to relieve pain, and told him to change from city to cistern water. Three days after I was recalled, and was surprised to find him still in bed with diarrhoea. as bad as ever, notwithstanding he said he had used no city water. Investigation showed that he had changed to soda water manufactured from the city water. Thirty- six hours' use of cistern water enabled him to return to his business. In my own family, where we use cistern water en- tirely for drinking and cooking, none of the family or servants ever has winter Cholera. Amusing cases sometime occur. A family who be: lieved the city water perfectly good, but who never used it, called me to see a friend from out of town who Was visiting them, and was taken quite violently with diar- WINTER CEIOLERA IN POUGHKEEPSIE. 525 rhoea. The lady of the house said: “Now, my friend's illness cannot be caused by the city water, as we never use it.” “Why,” said her friend, “it can, for I have drank two glasses from the faucet every night on retir- ing.” Such cases can be furnished every winter, well marked, easily traced, and as easily cured by change of water, but it would be useless to multiply them here. Now, what is it in the water which causes such a diar- rhoea. ? Evidently the sewage, or some product of it. Frankland says, “That chemical analysis cannot dis- cover the noxious ingredient or ingredients in water pol- luted by infected sewage or animal excreta, and as it cannot thus distinguish between infected and non-infect- ed sewage, the only perfectly safe course is to avoid altogether the use for domestic purposes of water which has been polluted with excrementitious matter. “This is more to be desired because there is no practi- cable process known whereby water once contaminated by infected sewage can be so purified as to render its domestic use entirely free from risk.” The following is a chemical analysis made last Feb- ruary for the Superintendent of the Water Works, by T. M. Brown, Ph.D. The nitrates appear to have been very little, if at all diminished by filtering, while the nitrites were diminished one-half. On the 10th of February last, while the river was cov- ered with ice, three samples of water were collected at the pumping station and forwarded to Thomas M. Brown, Ph.D., of the Massachusetts Institute of Tech- nology, for chemical analysis. Sample No. 1 was taken from the inlet basin of the filter-beds; Sample No. 2 was taken from the outlet of the west filter-bed, which had been cleaned a day or two previous; Sample No. 3 was taken from the outlet of the east filter-bed, which had not been cleaned in six or seven weeks. For results of these analyses see page 526. § SAMPLES COLLECTED AND FORWARDED FEBRUARY 10, 1891, EXAMINED FEBRUARY 11, 1891. (Parts in 100,000.) APPEARANCE. ODOR. RESIDUE ON EWAPORATION. AMMONIA. * . I ºf * & Turbid-| Sedi- || 8 3 |}: #| 3 | Change on 5 § No. * * - Cold. | Hot. || 3 | # 5, 6 $3 tº a º Free O ity. ment. 3 ë 34: É Ignition. ââ Darkens with .0020; .0126 peaty and Dis- | Very somewhat dis- 1 Distinct Consid- tinctly faint or agreeable clayey. erable. .25 || musty. none. 7.10 | 1.15 5.95 odor. *.0086 2 | Slight | Very Darkens with .0070 clayey. slight. .20 | None. None. 7.10| 0.80 (6.30 peaty odor. .0000|*.0060. Very 3 | Slight | Very faint or Darkens with . 0074 clayey. slight. .25 | None. none. 7.15 0.90 6.25 peaty odor. }:0000%.0066 The residue on evaporation was obtained from the water after filtration through paper in the laboratory. The Second determination of albuminoid ammonia, in each sample marked with star, is obtained from water which has been filtered through paper in the laboratory. ---i .08 . 12 § 3; #|g #4. #5, a § 2; § 2; ã, tº # ă ă ă 80 ºr q> 5 *#|É *ālā ā;|5 ##|-3 = Ž Z|z 2 & #|& "3|8 É .0420 .0002. 3.80 0.20 .45 .0400 .0001| 3.70 || 0.30 .37 .04001 .0001 3.80 i0.20 | .39 TWINTER CHOLERA IN POUGEIKEEPSIE. 527 On the 17th of February five samples were collected and forwarded to the same person for similar analysis. Sample No. 4 was taken from the Hudson River at a point one hundred feet out from the space of the pump- ing station dock, thirty-four feet below the surface of the water, and twelve feet above the bottom of the river. Sample No. 5 was taken from the Hudson River at the face of the pumping station dock, nine feet below the surface of the water, and about nine feet above the bot- tom of the river, being at or near the end of the inlet to the pumping well. Both these samples were taken just after high water. The river was covered with ice. Sample No. 6 was taken from the intermediate or outlet chamber of the filter-beds after the water had passed through the beds. Sample No. 7 was taken from the reservoir on College Hill. Sample No. 8 was taken from the drink- ing fountain at the Soldiers’ Fountain. For results of these analyses see page 528. The superintendent, in commenting on this, says: “A comparison of these analyses with those made on May 1st of last year, shows, in the recent samples, a very slight increase in the chlorine, and a considerable increase in the nitrates. The nitrites of the river water are the same, but are present in very small quantity in the filtered water. “The free albuminoid ammonia and organic matter represented by loss on ignition are all less.” The conclusion reached by Superintendent Fowler is “that no harmful or important change is indicated by the chemical analysis.” How he reached that conclusion I do not know. Frankland says: “River water should be considered dangerous water if, on inspection, any part of the pre- Vious contamination be traced to the direct admission of SeWage Or excrementitious matters.” Here there can be no question of the admission of sewage; the real ques- tion is, does the filtration render it safe? Frankland says: “Other epidemics, such as dysentery § SAMPLES COLLECTED AND FORWARDED FEBRUARY 17, 1891, EXAMINED FEBRUARY 18, 1891. (Parts in 100,000.) APPEARANCE. ODOH. RESIDUE ON EYAPORATION. AMMONIA. | 3 |# g;| = g|... g;|, g;| = , • * – 13. , is 3 |#|ä, älä, älä, äläisälä, ä No.] Tºrbid-| Sedi: | 3 || Cold. | Hot. 3 zāā § | Change on Free, £3 || 3 |É ##|É ## äää ### §5 # ity. ment. 3 É 3 *f; | * Ignition. 3.5 |F : ; ; ;|É Ālā. #3 ° à H Prº 3 || O Z, Z |z| Z E : ~! 4 |Distinct.|Consid— Very Distinct- 0.136 erable faintly ly 9.00) 1.25 |7.75|Darkens with .18 .0400 .0002. 3.80 0.70 | .46 earthy. .20 musty. mouldy. peaty and dis- agreeable *.0086 Dis- odor. .0042 Consid- tinctly 5 |Distinct.] erable Faintly vege- - earthy. .25 earthy. table. 9.25| 1.40 |7.85|Darkens with .0114.14 .0480 .0002 4.00 || 0.80 .50 peaty odor. .0026 6 | Very | Very Very | None. 7.60) 1.25 |6.35|Darkens with *.0068.13 .0680 .0001| 4.00 0.80 .31 slightly slight. faintly peaty odor. .0000 clayey. .10 earthy. 7 | Very Very Very slightly slight, .20 | None. faintly clayey. - vege- w .0080 table. 6.70] 0.95 |5.75|Darkens with *.0062]. 12 .0480 .0001 || 3.80 0.80 .34 peaty odor. .0000 .0078 8 || Very | None. .20 | Very | None. 6.90 0.95 |5.95|Darkens with *.0062]. 12 .0480 .0001| 3.80 || 0.70 | .35 slightly faint or peaty odor. .0000 .0042 clayey. In One. * .0028 The second determination of albuminoid ammonia, in each sample marked with star, is obtained from water which has been filtered through paper in the laboratory. WINTER OHOLERA IN POUGHKEEPSIE. 529 and diarrhoea, are also probably propagated by drinking water, but the evidence is here neither so abundant nor conclusive as it is in the case of cholera and typhoid fever,” and although the improvement of excrementally polluted water by filtration may reasonably be consid- ered, on theoretical grounds, to afford some feeble pro- tection against the propagation of epidemic diseases by water, no trustworthy evidence can be adduced in sup- port of such a view. On the 13th of October, 1892, I had a bacteriological examination made of two samples of water, No. 1 taken from the river alongside the dock at the pumping-station, and No. 2 taken from a tap in my office. The examina- tion was made by Dr. Edward K. Dunham at the Carne- gie Laboratory, and is as follows: Sample No. 1 was examined in duplicate for the number of viable bacteria contained in one cubic centimetre. The figures were 39,809 and 40,608, respectively, or an average of 40,209. This is, of course, an enor- mous number. But when we consider the length of time which elapsed between the collection and examination, it is altogether likely that there Was a multiplication of the species originally present. There were a number of various species of bacteria present, but I could find none of the usual forms found in putrefying substances, or any of the species common in faecal matter or sewage. I, therefore, attach little sanitary importance to the mere number of bacteria present, and am inclined to think favora- bly of the water for household use. - Sample No. 2 contained, in two portions of 1 c.c. each, 15,096 and 15,092 respectively, an average of 15,094. The number of species was less than in Sample No. 1, the vast majority being of but a single variety not uncommon in water, and not injurious. This water strikes me as being preferable to the other, but I see no reason to question the safety of either. Yours very truly, EDWARD R. DUNHAM. The report on sample No. 1 was rather a surprise to me, even at this season, when there must be sewage in the river; and this report is given to show that, at this Season, the examiner did not detect much trouble with the unfiltered water. From the clinical facts and the *Crease of nitrates and nitrites, in the winter over that in May, I am still unable to come to any other conclusion 34 530 NETW YORK STATE MEDICAL ASSOOIATION. than that the river water is the whole cause of winter cholera ; that the danger must increase with the increase of Sewage incident to a larger population, and that event- ually Hudson River towns will be obliged to find some other supply than the river water. SUGGESTIONS RELATING TO IMPROVEMENT OF QUARANTINE. By STEPHEN SMITH, M. D., of New York County. (Read by title November 17, 1892.) The continued presence of cholera in Western Europe and the recent arrival in New York harbor of several steamships on which the disease appeared during the voyage has awakened a new interest in the quarantine defences of this country. And this interest has been greatly intensified by the occurrences on the arrival of these vessels at the port of New York. They demon- strated the total incapacity of the most important guarantine in the United States to meet the emergencies that may arise at any time when travel and commerce are unimpeded. The apprehension which now prevails that there will be a recurrence of the epidemic in the Seaport towns of Europe next season, and that the quarantine at this port will prove ineffectual, both in its appointments and management, to prevent the introduc- tion of the pestilence into this country, will doubtless lead to efforts to secure State and national legislation, designed to remedy existing defects and evils. Whatever efforts are made should be based on principles established by Sanitary science and recognised by the medical pro- fession. It seems eminently proper, therefore, that this Association, representing the profession of the State in Which the chief quarantine is located, and by which it Was established, is maintained, and managed, should at this time consider this great public health question, and express an opinion which will tend to guide legislative action. In this view the following paper has been pre- pared. 532 NEW YORK STATE MEDICAL ASSOCIATION. The question of improving the quarantine of New York may be considered, first, in respect to the enlarge- ment and perfection of the present establishment; and, secondly, with reference to supplementing or supersed- ing it by a national quarantine. The propriety of endeavoring to place our present quarantine in condition to meet the demands that may be made upon it early in the next season may be seen when we consider its construction and surroundings. The establishment is located on two artificial islands in the harbor. They were constructed at great expense by the State, owing to the intense opposition of the people to the former location on Staten Island. This opposition was so violent that the former buildings were burned, and the Legislature passed an act forbidding the location of quarantine on Staten Island and on Long Island. There was, therefore, no other alternative left to the State but to construct these islands. Like all work of this kind the construction proceeded slowly, and the expense was very great. When finally completed, the quarantine consisted of two islands of limited capacity, one for the care and observation of well persons removed from in- fected ships, and the other for the care and treatment of the sick. Provision was made for but a single conta- gious disease. The capacity of these islands was for the proper care of a single infected steamship, with not to exceed one thousand passengers—of whom two hundred and fifty might be “suspects,” and seven hundred and fifty well, but who had been residents of this so-called infected ship. The arrival of two or more such ships in quick succession would, as was proved in September last, create such a congestion as would render it impossible to remove the well from the ships. The travelling public must not only be subjected to great hardships under such circumstances, but they would be exposed to the danger of contracting the disease prevailing on shipboard while at quarantine. The only method of rendering our quarantine adequate SUGGESTIONS RELATING TO QUARANTINE. 533 to meet the demands of the increasing travel and com- merce at this port is to enlarge its area. There should be ample surface area to extend its accommodations to a limit equal to the largest demand that can be made upon the establishment. But how is this enlargement to be effected ? It is impossible to occupy any part of the shores of the bay belonging to the State, or any part of Long Island, for the purposes of a quarantine. Not only does the law forbid such occupation, but public opinion is so firmly fixed and determined that it will be im- possible to secure necessary legislation to that end. The only method of enlargement is, therefore, by increasing the capacity of the present islands, or by the creation of new islands. It is only necessary to state these facts to prove that there is no possibility of relief from the pres- ent situation by attempting to improve adequately the present quarantine. The State will never be induced to incur the expense necessary to such an undertaking. Nor, indeed, should it be required to create and main- tain a quarantine of the dimensions and cost which will meet the present and future wants of the country. This is an obligation which now devolves upon the national Government, and it should be required to assume that Obligation at once. Fortunately, all of the conditions are favorable for the immediate organisation and equipment of a national quarantine at this port. Sandy Hook, which belongs to the general Government, is, according to recent advices and events, immediately available for such purposes. There are ample unoccupied lands which afford the necessary area for such an establishment, whether to meet present or any future requirements. The location can be thoroughly adapted to the wants of commerce, the anchorage is good, and the surface area and soil are all that could be desired for the arrangement and con- struction of the necessary buildings. Here can be created * Station for infected ships which will admit of the *mmediate removal of the sick and well from on ship- 534 MEW YORK STATE MEDICAL ASSOCIATION. board, whatever their numbers may be. The sick can be taken to hospitals adapted for a variety of contagious diseases, and the well or “suspects' can be separated into any required number of isolated groups in pavilions, where they may have every convenience necessary to their comfort and health. Here also can be warehouses for the reception, cleansing, disinfection and ventila- tion of every form of baggage and every variety of cargo. And, finally, here can be maintained, in a state of con- stant efficiency, every agency essential to the rapid cleansing of an infected ship. With such a station in this harbor there would be no need of any proclamation of a twenty days’ quarantine for the purpose of restrict- ing immigration. Nor would there be prolonged deten- tion of passengers for observation, nor the withdrawal of ships from commerce for long periods for proper disin- fection. Two questions will naturally arise in the minds of those who may not be familiar with recent national legislation in relation to the quarantine system of the United States: 1, Is it practicable to secure the location of a national quarantine in this harbor ? and, 2, if such a quarantine is established will it not conflict with the State establish- ment 7 The first question seems to be already answered in the affirmative. The Government has taken the initiative, and laid the foundations of a station that can rapidly be enlarged and adapted to supply every want and condition of the most perfect modern quarantine establishment, and in time to meet any emergency during the next Se2SOJOl. It may be objected that the camp created on Sandy Hook by the Government is a temporary expedient to meet an emergency, and that a permanent quarantine cannot be secured without legislation by Congress that would involve contention and delay. Happily, this is not true; but, on the contrary, the creation of a quarantine in New York Harbor and its complete equipment by the SUGGESTIONS RELATING TO QUARANTINE. 535 general Government would be simply an extension of the policy which it has pursued for the last decade. A brief review of the course which the Government has followed during that period in regard to the protection of the United States against the introduction of contagious and infectious diseases, will show not only that the establishment of a national quarantine at New York would be in accordance with its present policy, but will prove that the Government is under obligation to create such a station for the benefit of the commerce of the North Atlantic coast. In 1880 the National Board of Health, after the sup- pression of the great epidemic of yellow fever of 1878–79, in the Mississippi Valley, began to inaugurate methods of preventing in the future the introduction of conta- gious and infectious diseases into this country. A care- ful inspection was first made of the quarantines of the United States, which, at that time, were all State and municipal Organisations. It appeared from this inspec- tion that our seaboard and Gulf quarantines were, with One or two exceptions, utterly worthless. As a rule they Were maintained as a part of the local or State political machinery, with no pretense even of performing any useful public service. The best establishments were deficient in area, in buildings, and in appliances for the proper treatment of infected ships. The plan adopted by the National Board to meet the exigencies found existing was to supplement these local Quarantines by a series of national quarantines, called Refuge Stations. These stations were to be, and have been, located at such points along the coast as would be nost convenient for infected vessels bound to ports in the vicinity. In pursuance of this policy stations have been created for the Gulf ports, One at Chandeleur Islands, and another at Key West ; for the South At- lantic ports one is located at Blackbeard Island, Sapolo Sound, off Savannah; for the Middle Atlantic ports, one * at Cape Charles and another at the Delaware Break- 536 NETW YORK STATE MEDICAL ASSOCIATION. water. In the same manner for the Pacific ports, there is one at San Diego, another at San Francisco, and a third at Port Townsend, Puget Sound. The only part of Our Seaboard that has not been supplied with these stations is the North Atlantic. . These Refuge Stations form a series of exterior quaran- times, which are at all times to be maintained in a state of the greatest efficiency. They occupy isolated posi- tions, generally insular, and have ample areas admitting of any necessary isolation of passengers and their segre- gation into groups. They are to be fully equipped with every appliance required for the quick restoration of an infected ship to its service. In practice, any infected or suspected vessel bound for a port in the district in which a national quarantine is located, would first proceed to this station and perform quarantine before it attempts to enter the port of destina- tion. No local quarantine officer should allow such a vessel to enter the port which does not bring a certificate of having performed quarantine and been satisfactorily cleansed and disinfected at the national station. This quarantine system finds its best illustration in England. The coast of that country is divided into quarantine districts, and for each district there is a single well-equipped Government quarantine. To this station every infected vessel must proceed and perform quarantine before it attempts to enter any port of the district. The great value of this system is seen in the thorough protection which it affords a country against the introduction of a foreign pestilence. It creates two lines of defences, an exterior, where the infected vessel and passengers receive prompt and efficient care and treatment, and an interior, at which every vessel, whether infected or suspected, is intercepted and turned back to the Government quarantine. Again, it insures at proper places along the entire coast thoroughly efficient quarantines, always ready for, and capable of meeting any emergency. The importance SUGGESTIONS RELATING TO QUARANTINE. 53? of this fact will be recognised when we examine local quarantines in the absence of any alarm in regard to an epidemic. With rare exceptions they are allowed to go to decay, owing to the great cost of maintaining them in a state of efficiency. Perhaps the quarantine at this port has been more liberally sustained by the State than any similar establishment in the United States, and yet when a cholera-infected ship suddenly entered the har- bor in 1887 it was wholly unprepared for the occasion. Though the next legislature granted a large appropria- tion, and very extensive additions and improvements were made, yet on the arrival of the recent cholera ships much of its equipment was found too defective to be of any service. In regard to the relation of the local to the national guarantines it is apparent that they should act in har- mony. There should be no friction. The local quaran- times should continue to immediately guard their respec- tive ports against the introduction of any infections or contagious disease, and two or three might perhaps be relied upon to quarantine vessels having the milder. forms of these affections on board, but they should de- pend upon the national establishment to care for vessels bringing cholera or yellow fever, or to meet any emer- gency. If any legislation by Congress were necessary to place the national quarantine stations in their proper posi- tions, it would only be necessary to pass a law dividing the seaports into quarantine districts, and require every infected or suspected vessel, bound to any port, to per- form Quarantine at the national station for the district in Which the destined port is located. The same pur- Pose Would be accomplished if Congress would pass the following section of a bill reported by the Committee of Commerce and Manufacture to the House of Represent- atives, as early as May 7, 1796: “Be it enacted, etc. The President of the United States be, and is hereby authorised to direct at what 538 NEW YORK STATE MEDICAL ASSOCIATION. place or station in the vicinity of the respective ports of entry within the United States, and for what duration and particular periods of time, vessels arriving from foreign ports and places, may be directed to perform quarantine.” + The quarantine at the port of New York, in the event of the creation of a national station at Sandy Hook (or, indeed, in any event), ought to be placed under the juris- diction of the Health Department of the city of New York, which should be made responsible for its proper management. Its officers and employees should be ap- pointed by that department, and the chief officer should be the Sanitary Inspector of the Port. The laws relating to the government of quarantine should be repealed, and 1 One of the most vigorous supporters of this bill was Mr. Smith, of South Carolina. He said: “If this question be a mere question of acqui- escence in the State laws there might be a propriety in the Federal Gov- ernment overlooking those laws; but it was essentially connected with the powers of Congress on an important subject. He had been surprised to hear gentlemen assert that this subject was not of a commercial nature. The gentleman from Virginia had said diseases were not articles of im- portation, or, if they were, they were contraband, but gentlemen must know that importations of all kinds were under the regulation of Congress, and contrabands as much as any other. Consider how epidemics, im- ported, affect the United States at large. They do not merely affect the city where first imported, but they obstruct the commerce of all others; they not only embarrassed the commerce, but injured the revenues of the United States. Another point of view in which it had an effect : the laws regulating the collection of imports were counteracted and obstructed by the laws regulating quarantine, and would any gentleman say that a State legislature had the power to contravene the act of the Federal Govern- ment, to obstruct all of the laws by which it collects its revenues. It had been said that this subject could be better considered in each individual State than we could possibly settle it. Who are we? Are we a foreign government 7 Gentlemen had already forgotten their arguments on former occasions when speaking of the power of the House; they could then do anything and everything, and the people looked up to them alone for Prº- tection. If the subject was vested in the General Government it Was their business to protect the health of their fellow-citizens as much as their property; because if the performance of quarantine was neglected, such neglect naturally tended to affect the lives as well as the revenue and Coº merce of the citizens throughout the United States. He, therefore, thought it a subject perfectly within the Federal jurisdiction.” SUGGESTIONS RELATING TO QUARAWTINE. 539 the Health Department should be authorised to make such rules and regulations relating to the inspection of vessels, their proper care, and the details of administra- tion of this sanitary Service of the port, as it may from time to time deem necessary. Such a change in Our quarantine establishment would of itself be an immense improvement, for it would be brought under the imme- diate supervision of a department which has a vital in- terest in its efficient and Successful management. THE LIMIT OF RESPONSIBILITY IN THE INSANE. By JoHN SHRADY, M. D., of New York County. Movember 17, 1892. In consideration of the present topic, reference is to be had not so much to the psychological as to the legal aspects. In its discussion, the subject is to be applied to the view in the gross—just as it should be when the decision is to be made to the jury, who, after all, put the final construction upon the value of the facts. As a lawyer once remarked to me, the “law might not be synonymous with justice, but it is the nearest approach to it.” The individual involved in the consideration must needs be taken as the exemplar of what was likely to be done under similar circumstances, yourself being the subject. Now, for the purpose of more fully stating the argu- ment, let the suspect be studied as regards motive with the concomitant sequences of acts, where the personality of the culprit has been made exchangeable with One's own self. The limit of responsibility is quite difficult to fix, since many circumstances, with their value as affecting individual results, must be studied. What would be regarded as harmless or inconsequential in one individ- ual, may not be otherwise than direful or significant in another. Clews, upon which detectives lay so much stress, come in for their proper value; mental behavior and general habits much more. There may be in the minds of the jury all kinds of explanations, ranging from eccentricity to madness. There may be present SuS- picions of malingering, outbursts of temper, or a down- right set purpose of revenge; there may be discussions upon the presence or absence of remorse, congenital mental defects, temporary delusions that life Was tº jeopardy; there may be much criticism of facts, much RESPOWSIBILITY IN THE INSANE. 541 averaging of expert Opinions, and much confusion in the matter of technical interpretations. Let it be borne in mind that no attempt is made in this thesis to call up for deliberation the question of testa- mentary capacity, for the reason that too wide a scope must needs be given, and too many judicial charges cited. As in criminal cases, decisions in those having reference to bequests involving undue friendship at the expense of unimpeachable heirship, must be arrived at upon the merits of individual cases. As interesting as this field is, it is, as has been suggested, too wide for present pur- poses. Decisions, though erroneous in point of doctrine and opinion, Subserve the One purpose of settling ques- tions for the benefit of that community, which, after all, does not much care to occupy itself with the grievances of others. If precedents are many, and cases have been numerous or of startling magnitude, the court-room may be crowded, but the whispering mob seeks after the sen- sation merely. Much stress has been very justly laid upon the irresist- ibility of the will-power, or rather that the individual has become inexplicably the subject of circumstances OVer which he has no control. In fact, to make the Statement adjustable to the ordinary intellect, it were Well to take into account the ready belief of by-gone Centuries or epochs, that the subject was possessed of a daemon, which stalked the earth, alert for an entrance through a point of least resistance, the conception being that an accident confronted the community of which the maniac was only a part, and contributed to the catas- trophe in a manner which could not by any known pre- “aution be provided against. The irresponsible agent Was prominent, and the act became merely a part of the *tastrophe. The penalty required discussion, but the Culprit escaped through the convenient loophole of a doubt for his eSpecial benefit. But has the Community no rights or immunities that its P* must be continually threatened A Certainly not, 542 NEW YORK STATE MEDICAL ASSOCIATION. exclaims a vigilante, for these lapses, of necessity, must call for constant adjustment, and we are compelled to interrupt the usual business of Society for the mere sen- timent of perhaps saving a worthless life—for the as- sumption of a burthen which, at the last, does not pay even the cost of transportation. Society, too, in its pitiless way, allows but few obstacles to its progress as well as very little embarrassment of its machinery. The individual in its way may go down with a shriek, but the mangled corpse is soon removed because of its in- utility and unsightliness. Great indeed, however, must be the crime, and indisputable the evidence before the juryman convicts. He dreads the possibility of a mis- take, the fallibility of testimony, and the coloring of prejudice. He may question the ability of the judge, the propriety of his charge, and the purity of his motives. “The consciousness or knowledge of right and wrong” has long been held to be the legal test of responsibility, to which the higher law of humanity has added the more sweeping qualification of the loss or absence of self- control. Out of these definitions, for they have the force of such, is to be eliminated the trick of the mind of reasoning from false premises. The deduction, so ram- pant in mediaeval times, which phrased itself in the royal morals in the expression that “the king can do no wrong,” evidently can have no place in the logic of the situation. With the conceded obliquity there need be no conclusion that there were delusions of grandeur. At the bottom of the paternal form of government is a kind of hero-worship, contrived more for the convenience of the ruler than for the practice of justice among the people. It was the temper of the times, which enforced the submission, while of the popular mass, Some Welº sincere believers, others secret doubters. The king merely drew around his person the circle of a mysti" wand, at first to awe into obedience, but later to apºlº gise for his vices. Now, above the king is the limitatio" of constitutional law, extending from dethronement to RESPOWSIBILITY IN THE INSANE. 543 , decapitation. History has furnished many examples of both methods of disposal—methods which have been stamped by Succeeding generations as being both un- merciful and undeserved. They were, however, only the lessons of a moving drama, now toned down, and serving, like the red-shawled figure in the sombre land- scape, to guide toward still deeper gloom. Law at the present time takes more cognisance of in- dividual rights, and in juxtaposition of the rights of the state is more careful in the adjustment of the rights of both. The nature of an uncontrollable impulse has been happily expressed by a very emotional lunatic, who rounded up her career by suicide. “My intellect is all right—it's Only my feelings that are at fault.” Uncon- trollable impulse, then, is entitled to consideration by the jury in the case of the murderer, but deliberative plan- ning, never, unless it be that overmastering delusions were present and the victim in propria persona with Opportunities to beckon on to the crime, suggested the ease with which the deed might be done. But even here, qualifications come in to balk a summary verdict, the prisoner getting the benefit of the doubt. Thus the Community is more likely to suffer than the individual— the asylum, rather than the prison, or very distant chair, gallows, or guillotine, being the portion of the culprit. But, should an outraged community, driven at last to balance its books and summarise its assets, drum-head Court-martial the suspect, and hurry him to execution, the criminal community must content itself with a dying Speech or maudlin confession. Thus both are avenged. Besides the powerlessness of the will, absence of mem- 9*y is to be regarded as a feature of the non compos *** condition, for here comes the instant conclusion that facts have made no impression and the faculty of *lºgical reasoning is gone. Without these mental attributes there looms up the assumption that an appre- *tion of the corelative adjustment is gone, that the mind cannot keep books even by single entry. Drunk- 544 JNEW YORK STATE MEDICAL ASSOCIATION. enness, notwithstanding the legal theory that the indi- vidual takes a voluntary risk, is an instance of a mania, transitoria in its acute form ; punishment is apt to fol. low Swiftly and surely with all due form of law, while the influential criminal, after having been discharged cured from an asylum, resumes his position in society with the added flavor of the romance. Society is tolerant as long as the antics of the lunatic are harmless, amus- ing, and on the safe side of eccentricity. But let the patient—and this is the most convenient designation— give the freest play to his moods of violence, straightway it becomes alarmed, and puts itself upon the defensive. Then laws are enacted to preserve its autonomy, and in its comprehensive attempts to cripple its forceful mem- bers, tyrannises over the few. Again, if the suspect be really overcome by some in- scrutable power, hypnotic in action, and demoniac in expression, does society gain in an economic sense ; has it added to its ranks even a reformed straggler ? Let it not be understood that in the argument cruelty is in- tended; merely that just a moiety of political economy is taken into account. Popular clamor may condemn, but it does not always convict ; it may be provost mar- shal rather than judge ; the reversal of judgment may be read to the deaf ears of the corpse, and the attainder upon the property remains only to be removed, and that only for the convenience of passing title. The alleged culprit is dead, and society views the remains with Com- mendable indifference. Emotional supremacy out of the question, that inde- scribable mental element, denominated intuition, with its impossibility of being imparted or delegated, not Con- sidered, the powerlessness of the will, with all its subter- fuges against self-betrayal accorded its true weight, and the mere opinions of experts upon hypothetical cases are eliminated, after summing up the value of the proº and cons, why should the key of memory be thrown OVer the fence before it was inserted into the lock' SOME PERSONAL OBSERVATIONS AND REFLEC- TIONS UPON ALCOHOLISM, THE EFFECTS OF ALCOHOLIC ABUSE UPON POSTER— ITY, AND THE TREATMENT OF ALCOHOLISM. By H. ERNST SCHMID, M. D., of Westchester County. November 17, 1892. I do not know of any topic which is of greater im- portance than this to the individual, the family, and even to the nation at large. Alcoholism far exceeds in interest, magnitude, and wide-reaching consequences, morphinism or any allied vices. He who lives under the Constant influence of an opiate, will become conspicu- Ously obnoxious to those surrounding him only when deprived of the enslaving drug. In the majority of in- stances, he will commit acts of selfishness and cruelty Only when impelled by the bitterest misery to secure, at any hazard, the means of purchasing more opium or Cocaine, or whatever special form of anodyne or opiate to which he may be particularly attached. According to my, not small experience, when sup- plied sufficiently with all he craves, beyond being a social nuisance, he is comparatively harmless. But how different With the man who drinks to excess In many instances he becomes a brute, and acts brutally toward Strangers, friends, and relatives. In order to criticise, or select intelligently, a plan of treatment adequate to the greatness of the subject, it is but proper to Contemplate first the way in which alcohol damages the System. Of course, I speak of the damage Wrought by its abuse. 35 546 JNETW YORK STATE MEDICAL ASSOCIATION. The effectively-intoxicating part of all alcoholic bever- ages is called ethyl-alcohol, and by pharmacologists is properly ranked with the poisons; but, in common with other drugs of the same class, it is, in Suitable cases, pre- scribed by physicians, for, when a physician orders brandy in the form of cognac, his patient thus takes about 55 per cent. of ethyl-alcohol. When he orders Malaga wine (a favorite prescription for children in cer. tain countries), the little one gets from 17 to 28 per cent. of the same alcohol, and in lager beer, from 3 per cent. to 5 per cent. It has often amused and astonished me at the same time, when I have heard it said that lager beer is a non- intoxicating drink; for, the man who imbibes ten glasses of it, often but an ordinary feat, drinks about half a glass of pure ethyl-alcohol. This substance is carried into the blood, chiefly through the intestinal veins, and to some extent through the chyle-vessels. It speedily passes through the walls of the vessels, and the richer an organ is in blood, the more of the alcohol it imbibes. The rapidity with which the entrance of alcohol into the system is effected, is truly astonishing, for, in only a few minutes after it is swallowed, it can be found in the venous and arterial blood and in the main trunk of the lymph-vessel system. Again, the brain is the first Organ to absorb this poison from the blood, and, hence, also the first in showing its effects. It is thought that the action upon the nerve-centres is atomic or molecular in character. If the excess in drinking be slight, and of short duration, this atomic union will occur in a Very loose manner, so that the alcohol must soon let go itS hold again, so to speak; but where severe and protracted indulgences are practiced, the chemical affinities of the nerve elements are paralysed, and their life finally alto- gether destroyed. Next in order comes the heart, whose action is quickened, while the tension of the arterial walls and the blood pressure is lessened. The blood it self is not changed by the alcohol. OBSERVATIONS ON ALCOHOLISM. 547 * Upon the digestive function alcohol exerts a peculiar influence. Small doses, diluted, stimulate and increase the secretion of the gastric juice; whereas, large amounts interrupt, delay, or entirely suspend it. Competent observers maintain that any quantity at all, if taken during the process of digestion, produces the latter effect. According to almost all observers, tissue-change is decreased by the use of alcohol. The breathing, at first accelerated, gradually grows slow, and the excretion of carbonic acid is lessened. The temperature of the body is affected only by large doses, which lower it. A great expenditure of warmth is caused by the dilatation of the vessels of the skin, by paralysis of the muscles, and by a reduction of the oxidising processes in the tissues. A study of the intoxicating and, hence, destructive effects of alcohol upon the child, furnishes a guide to the proper treatment of alcoholism in the adult. The child shows far more clearly its powerful effect on the nervous system. The first stage is almost always one of excita- tion, though this is occasionally absent in the child, as Well as in the adult, either on account of a large dose being taken, or because of individual susceptibility. This stage of excitation is marked by a great sensitive- neSS to external excitants, and by most active muscular unrest, often progressing to light muscular spasms of a clonic or general tetanic character. In the next stage, the child becomes deeply depressed; there is a relaxation of nerves and muscles, resembling paralysis. In this Coma-like condition, it may lie from twelve to thirty-six hours, being roused with difficulty, and only for a few iminutes at a time. Occasionally, I have said, there is an absence of the first period of excitement, and then the rapidity of the absorption of alcohol is exemplified by its almost lightning-like action upon the central ner- VOuS system. once saw a man drink a full goblet of whiskey, and * less than five minutes, a second. A third was *ttempted, when all at once the glass fell from his hands, 548 NEW YORK STATE MEDICALL ASSOCIATION. and he lay senseless upon the floor. He was ill for weeks at the doctor's house. During the first week of September I was called to see two cases of alcoholism which were to be treated at the Keeley Institute. Both, however, arrived in so terrible a condition, that I was sent for to see if they could be roused from the almost coma-like state in which the last drink had placed them. It was impossible. One expired within fifteen minutes of the time I first saw him, and the other within two hours. The latter presented a very interesting point. He was pulseless, unconscious, insensitive to any touch; his feet and hands were cold. I gave him hypodermatic injections of brandy, and he reacted. In an hour he was perfectly conscious, answering all questions, but he lived only about two hours from the time I made my first visit. I mention these cases on account of the interest- ing deductions to be drawn from them. We should always bear in mind when prescribing alcohol for a child, that it not infrequently produces convulsions in the infant; and furthermore, that even very small doses of it act only transiently, as a vivifier and apparent strengthener of the nervous system ; even then, such effects are soon followed by relaxation. In reality, alcohol only transiently benumbs the feelings of weariness ; and finally, in larger doses, produces a momentary, but never an enduring strength. It is, therefore, indicated medicinally only in that pathological condition which approaches collapse, and in which there is a frequent and small pulse. In such cases, alcohol may serve to “tide over,” by causing temporarily a slower, fuller, and stronger pulse. We should also never forget, that in tea and coffee, more particularly the former, we have the agents, par eacellence, which raise and sustain strength in muscular and mental labor. The wife of Lieutenant Peary, lately returned from a most successful North-Pole expedition, informed me that tea almost always, coffee rarely, was their beverage. Alcº: hol some time ago was excluded from the quartermaster's OBSERVATIONS ON ALCOHOLISM. 549 department of Northern expeditions. It is a mistake . on the part of any practitioner to direct even the smallest doses, long continued, of alcohol in water or milk, to be given with a view to imparting strength. This it will not do, but will disturb the natural course of digestion by inducing chronic irritation of the mucous membrane of the stomach. Chronic and intractable gastric catarrh, enlargement of the intestinal lymphatics, rapid loss of weight and strength, and in a few instances, cirrhosis of the liver, are some of the pathological changes following long-continued use of even small doses of alcohol. But what are these effects compared with those wrought upon the central nervous system of the child? They are not surprising, when we recall to mind the grave and constant anatomical lesions which develop in the cere- bro-spinal system of the adult alcoholist. The very delicate nerve-elements of the child are still in a very active state of development—i. e., more full of blood than later in life—the meninges are therefore very prone to congestions, to dangerous serous effusions, and to in- flammations. For these reasons, alcohol must affect the child a great deal more injuriously in this, the most im- portant organ. From its baneful influence often arise epilepsy and chorea. That, in many cases, this is the Cause, is recorded by thoughtful and investigating physicians, and has been proved by the happy cure of these dreadful nervous disorders as soon as its use was discontinued. . I cannot resist alluding with a deep-felt word of warn- Ing, to the pernicious practice of allowing and even prescribing for nursing-women the systematic use of alcoholic drinks, with a view to producing a greater flow of milk for the baby; it is often advised by the family Physician, and the hired wet-nurse stipulates as her *ight, a certain daily allowance of beer or whiskey in the shape of milk punch. Can a sadder mistake be made "hese same men who allow or advise the practice, are doubtless Opposed to the use of so-called swill-milk, 550 IVEW YORK STATE MEDICAL ASSOCIATION. which means milk from cows fed on distillery grain, by the eating of which they are kept in a chronic state of mild intoxication. But opposed as they are to the em- ployment of swill-milk for adult or child, they help to produce in the human female a similar Swill-milk for the poor infant. Competent and close observers have dis- covered a connection between this habit of the mother and the development in the children afterwards of true imbecility, and even idiocy. Of all the effects upon the nervous system of the child, however, the most distressing and far-reaching is that upon the moral power, upon the morality of the being. Alcohol paralyses this. The youth, who, so to speak, was alcoholised as a child, gives free rein to his pas- sions; his will-power stands at Zero ; neither dissipa- tions nor crimes have any terror for him at the very first meeting ; and he not infrequently ends his career as a suicide. Neurasthenia is a growing evil, even amongst the school children. Think how one admires, almost as a curiosity, a really fresh, sound, healthy child. As head of Our local Board of Education for many years, I have given more than usual attention to the young in my district, and I have been astonished to find how many pupils at the age of twelve to fifteen, complain of headache, palpitation of the heart, insomnia, and bad feelings generally—or perhaps they are dull and indifferent to everything, and evidence great weakness of memory, unnatural sleepiness, and easily induced exhaustion. Parents of such unfortunate and uninteresting and non-progressive children are very apt to lay all the short-comings of their poor children to the fault of the much-suffering teacher. What must be the effect of all such lesions if allowed, unchecked or unremedied, to go on into adolescence and manhood? I think far beyond the wretchedness with which it burdens the entire life of such an adult, is to be considered the inheritance it bequeaths to the children. OBSERVATIONS ON ALCOHOLISM. 551 Heredity is an unquestioned fact at this age. We know that qualities of the parents reappear in the child. A child whose father died before it could recognise or remember him, will often exhibit the same peculiar gait in walking. If, occasionally, the child will escape such inheritance, the grandchild may have it. Some families, from generation to generation, inherit mathematic or artistic capacity. If virtues and great traits are inher- ited, why should not defects, dispositions to diseases of body or mind, or of both be also inherited . There is no question that the drunkenness of parents can and does entail the love for drink upon the offspring, or it may at least very decidedly imperil life and health. When we reflect on the fact, that inheritance makes the good or bad quality or defect of the parent stronger in the Offspring, this matter assumes a far graver aspect. The craze for drink, the so-called acute alcoholism, alcoholic mania, dipsomania, delirium tremens, chronic alcoholism, specific alcoholic psychoses—all are classed with mental disorders. As such they can descend to the children. Dipsomania can be transmitted from father to child, or else the effect of such defect in the father may produce an otherwise injured mentality in the off- Spring. It is astonishing how early this was recognised, for Plutarch uttered this startling sentence: “Ebrii 9?gnſunt ebrios”—Drunkards beget drunkards. The following facts have been collected, all pointing in this same direction: 1. A man became a drunkard after middle life; chil- dren born to him before his degradation remained free from the vice of drunkenness, while those born after- Ward, became drunkards. 2. Erasmus Darwin states that diseases inherited from drunkards descend to the third and fourth generation, until, finally, the family dies out. - 8. Another observer Says that of ninety-seven children Of drunkards, Only fourteen remained free from some defect. 552 NEW YORK STATE MEDICAL ASSOCIATION. 4. Still another maintains, that fifty per cent. of the idiots and imbeciles of great cities are the children of drunkards. 5. The children of drinkers inherit the same or a larger predisposition to nervous disorders than those of nervous or really insane parents. They suffer most frequently in infancy from convulsions and epileptiform diseases. 6. Districts known as “drinkers' districts” in Europe furnish far fewer good recruits for military service. 7. A law was made in Sweden against drunkenness, 7. e., making it a punishable offence, and since then the number of persons unfit for military service on account of undersize and general weakness has grown much smaller. 8. A distinguished specialist on children’s diseases observed ten families of drinkers, and ten of temperate parents for a period of twelve years. The ten drinker- families produced in those twelve years fifty-seven chil- dren. Of these, twenty-five died in the first weeks of life, of weakness, of convulsive attacks, or of oedema of the brain and membranes; six of them were idiots; five were stunted in size, and were of real dwarfish growth : five, when older, became epileptics; one, a boy, had grave chorea, ending in idiocy; five had inherited dis- eases and deformities, such as chronic hydrocephalus, hare-lip, and club-foot; two of the epileptics mentioned became, by inheritance, drinkers. Only ten, therefore, of all these fifty-seven, or 17.5 per cent., showed, during youth, normal disposition and development of body and mind. The ten temperate families produced in the twelve years sixty-one children. Of these, five died in the first weeks, of weakness; four, in the later years of childhood, had curable nervous affections; two only showed inherited nervous defects. The remaining fifty, or fully 81.9 per cent., were normal in every way, devel- oping well in body and mind. My friend, Dr. Wandenburg, has kindly furnished me with a list of forty-four patients treated by him for alco: holism. On examining the notes carefully, I find that OBSERVATIONS ON ALCOHOLISM. 553 twenty-five of them had ancestors, or, any rate, relatives, who drank. Of ten of them, there was no previous his- tory obtainable. These, very likely, ought to be added to the twenty-five, as it appeared from certain signs that they merely did not wish to expose their family his- tories. It is a curious but very general fact, that there exists a sort of instinctive tendency in the members of a family to hide from others, as well as from themselves, anything which would tell of a defect by a faulty nervous inherit- ance — I mean an inheritance of defects in the central nervous system. Men do not like to acknowledge the controlling effect of such a fate, and they often instinct- ively take pains to refer diseases which are unmistakably inherited, to very ordinary, accidental, and always differ- ent causes. To try to obtain information in such matters from family members is too frequently a fruitless under- taking. They will often throw impediments in one’s way, even leading one into wrong paths. And yet to make a proper diagnosis and prognosis in nervous dis- eases, one must try to learn not only the history of his patient, but also the diseases which are prominent in his family. But to return to my Wandenburg statistics: Four mothers and sisters are consumptives; one has a father Who is very nervous and smokes incessantly; one has an asthmatic grandfather. Only three have a family record Which seems free from all defects. Eleven of them showed consumption or some lung difficulty in their families; one had insanity on the mother's side, and of 9ne, the father's sister was insane; of one, the uncle and aunt on the father's side were insane, and one had in- Sanity in two aunts on the father's side. There was insanity in the father of one, induced by drink, and in * instance the paternal grandfather drank heavily and * father moderately. In one case the paternal grand- *ther drank hard and died of apoplexy ; the great- §randmother was Consumptive, and the mother paralytic. 554 NEW YORK STATE MEDICAL ASSOCIATION. In four instances the grandfathers drank heavily, though the fathers were free from the vice. All these researches only point the more strongly to the importance of ascertaining the best methods, if there exist any, to stop the disease and its ravages. The establishment of a so-called Keeley Institute at the village where I reside, has brought to my mind with more than common emphasis the subject of the treatment of alcoholism, craze for drink, or dipsomania. It is to be deplored that the State has not created special laws for the legal commitment of drunkards, and erected suitable institutions in which these unfortunates could be confined, treated, and kept until not only well of a debauch, but until their will-power had been re- established. The only institution near New York for the treatment of drunkards is not calculated to do all this. There, they are simply helped over a spree, and set afloat again as soon as sobered and restored to sleep and appe- tite. Nothing is done to help them improve or recreate their moral strength, which, after all, is the great point to be attained. I have sent alcoholic habitués to the insane asylum. This, also, is not a proper place for them, and besides, one has often to strain points to bring such cases before the Commissioners in Lunacy in Such a way that they will allow them to be received in an asy- lum for the insane. The Keeley system, which I have had much oppor- tunity to observe, has something in it which none of the formerly established institutes have ever shown. It tries to reach the mind, and hence to establish on a new basis the dethroned will-power. This is done, first of all, by an appeal to the patient's honor. And the great Success which in the beginning seemed to follow this method of cure was unquestionably due to the fact that the ma" jority of the earliest patients were of the very best class, men of intelligence, who were willing and anxious to be cured. These patients helped themselves by their desire to be helped. Then, there existed a sort of brotherhood OBSERVATIONS ON ALCOHOLISM. 555 among them — a feeling of kindliest interest in each other’s improvement. A later arrival on expressing him- self still miserable, after a few days’ treatment, was strengthened by older patients saying, “It was so with me too, but a few more days will help you.” Then, sure enough, in a few days the later arrival would all at Once say to himself: “Well, Isee these others gave up alcohol ; I can do so, too,” and he would do it, and then every day carried him farther away from the beverage, and left him feeling better and better. Then, although his mind cured him, being impressed with the idea that Some secret, subtle means had been used to produce this bene- ficial work, he cherished a growing belief in the marvel- ous effects of this treatment. It goes without saying, that I by no means advocate the secret manner in which the Keeley system is prac- ticed. It is wonderful, nevertheless, to note the many Successful cures made by it. What helps to increase in the eyes of the public this success, is the ingenious way in which Dr. Keeley himself dismisses his cured patients, or “graduates,” as he strangely misnames them. Every evening—such is the practice at Dwight—the graduates of that day are requested to step into Dr. Keeley’s pri- Vate office before departing, to receive his final lecture. There he tells them : “Now, gentlemen, remember, I have filled your bodies with a poison inimical to alcohol. If in the next four weeks you return to your old prac- tice of drinking it, this poison which I have introduced into your bodies will kill you, by meeting alcohol within You. If you abstain for four weeks, but begin to digress from your present abstemious life, after the fourth week the same poison will make you seriously ill.” This is * ingenious plan to make his cases tell on the com- *nity, for the patients, after their return to their res- Pºtive homes, will be closely watched at first by the Pºple around them. But four weeks' escape, and no *pse into dissolute habits takes place. Interest begins t * e gº ° "ag; a four-weeks' wonder becomes tiresome, and 556 NEW YORK STATE MEDICAL ASSOCIATION. after another four weeks of continued steadfastness it ceases to attract attention. The best impression is thus left on the minds of the people as regards the Keeley treatment, and Dr. Keeley’s clever parting lecture has brought forth the desired fruit. The great object of my address to you is to rouse this Association into action, to urge it to petition the Legis- lature to pass the laws I have alluded to, and to vote money for the erection of a building dedicated solely to the restoration of drunkards. There is no need of bring- ing forward plans for effecting this restoration until a movement in the direction indicated has been crowned with success. I feel very strongly on the subject. The deep sympathy which a drunkard’s condition calls forth should impel us all to forward the good work. The establishment of institutions of this kind will be, in the end, of immense benefit to the public treasury. Only reflect on the labor power thus saved to the Common- wealth ! The skillful mechanic (and how often are the best given over to drink 1) will be restored to his family, perfectly confident again, and willing to be the bread- winner as of yore. The unfortunate who, during a crazy spree, has threatened perhaps the lives of people, will no longer go to jail to expiate a sentence in complete idleness, but will speedily be cured of his debauch, and at Once carry on remunerative labor in one of these institutions. It is sad to watch our present system. I will give you just one experience of mine. A few months ago a prisoner was brought into our jail in a most terrible condition—crazed by drink, with his face beaten into a pulp during self-provoked rows, and unwilling to be controlled in any way. The attending physician found him chained close to the floor of the cell, as dangerous and violent as a wild beast. A hypoder- matic injection of morphine restored him to his former quiet, and he was soon brought before the court and sº tenced to a certain term of imprisonment in the county jail. When the time of his release drew near, the judº OBSERVATIONS ON ALCOHOLISM 557 who had sentenced him requested me to examine him as to his mental condition, for the behavior of the man dur- ing his trial had led the judge to fear he was insane. I visited him at once, and found him a most intelligent, wide-awake man, who only a year ago had given himself up to drink, and had ever since lived in constant alco- holic excitement. Deprived of drink, he had perfectly recovered, and felt ashamed of his condition. The jail was not only not the place for him, but it was most detrimental to his moral condition. Thrown into close contact there with criminals of all shades, while his mind was still weakened from the long-continued and exces- sive use of alcohol, the former drunkard was in immi- ment danger of becoming a future criminal. There are people who have no patience with drunkards, just as there are those great masterpieces of virtue who can- not understand how one can ever be led by passion’s wild demands from the straight and practical road, whose every step is well calculated beforehand, and arranged in an undeviating routine system. But such people are possessed of natures which cannot be tempted—cold and Self-contained individuals, their virtues are to my mind no virtues at all, for they have never to sustain an on- slaught of the evil one. To them I do not turn for co- Operative sympathy, but to those scarred in many a bat- tle, won or lost. And it is scarcely necessary that I should portray for such, the many ways in which excel- lent men or women may become almost unconsciously enslaved by alcohol. Look around you, and see how many homes have been destroyed; how much happiness undermined ; how *uch of grief planted in the hearts of men and women by the unfortunate victims of alcoholic excess ; and then yOu will join in doing this great work in which my whole heart's energies are enlisted. After reading the paper, Dr. Schmid moved that a °9mmittee be appointed with power to endeavor to secure 558 NEW YORK STATE MEDICAL ASSOCIATION. the passage of a bill through the legislature, which would make legal the commitment of drunkards and morphin- ists to suitable institutions, and to petition the legisla- ture to make a sufficient appropriation for the erection of asylums devoted exclusively to the treatment of alco- holists and morphinists. Dr. H. D. Didama, of Onondaga county, suggested as an amendment, that a committee be appointed to take into consideration this question of the legal commitment of inebriates, and report on it at the next meeting. As thus amended, the motion was then put to vote, and carried. - The president appointed on this committee the follow- ing: Dr. H. Ernst Schmid, of White Plains, N. Y., and Drs. E. F. Brush and William D. Granger, of Mount Vernon, N. Y. DISCUSSION. DR. NELSON. L. NoFTH, of Kings county, considered the subject im- portant, and an appropriate one for action by this Association. We all know the way in which drunken people are thrust into jail and other places, and it certainly behooves medical men to think of these matters soberly and earnestly. These unfortunates are to be found everywhere, and they should be cared for in just such a place as suggested by the author. THE PRESIDENT thought we should consider well the difficulties in the way of legalising the commitment of these people. To what institution shall they be committed ? Neither the lunatic asylums nor the jails Want them, but he knew of no other places to which they could be committed except to private institutions; and in this connection he would remind the Association that Binghamton was formerly an institution of that kind, and proved to be such a complete failure that the State took it, and Con- verted it into an institution for the treatment of the chronic insane. DR. GEORGE Douglas, of Chenango county, said that he had been 9” of those who had contributed money to that institution for the sake of hav- ing the experiment tried, and as the President had said, it proved an utter failure; and others who had had a similar experience would probably * him out in the statement that such institutions were failures because theº" no manhood in these poor inebriates. He did not wish to discourage efforts at reclaiming these unfortunates, but only to point out the obstacles which had already been encountered; for, although his hairs were 8*Y with seventy years, he could not forget that from his earliest childhood his father had brought him up to abominate drinking habits. CLIMATOLOGY IN ITS RELATION TO DISEASE. By S. J. MURRAY, M. D., of New York County. JNovember 17, 1892. Being obliged a few years since to seek a more con- genial climate on account of my own health, I was led to a more thorough consideration of the subject of climate in its relation to disease. Climate we know is a fixture; the weather may change, climate does not. The people of the world are to-day beginning to learn that the great- est destroyer of human life has its remedy in climate. There never was a time in the world’s history when the advice of a physician was more eagerly sought for by the better classes, than at the present time, not alone on those subjects which pertain strictly to medicine, but on everything pertaining to their general welfare. On this account, our responsibilities, as physicians, are very great, and hence the necessity of our being qualified to meet the demand. The time is not far distant when the duty of the physician will be rather to instruct the peo- ple how to live so as to avoid disease, than to treat dis- ease; and the great object of this paper is to emphasise the importance of giving intelligent advice sufficiently early to save the life of the patient. Our first duty, then, consists in the proper education of the human race with a view to avoiding disease. To what extent are we as physicians responsible for so much *ase? It has been fashionable of late to attribute disease largely to the poor little microbes, which have been at- tacked in all conceivable ways; but still they move and have a being, and existin as great a variety and number as *Ver. While I believe them responsible for many dis- * I do not attribute as much to their agency as has 560 NEW YORK STATE MEDICAL ASSOCIATION. been claimed by some. We are greatly indebted to the bacteriologists of the present day for their many valuable discoveries, but the question here arises, how much bet- ter are we prepared to treat the diseases caused by germs, from Our having made the discovery of their existence # Professor Koch made a wonderful discovery when he found the tubercle bacilli; but with all his knowledge he has failed to discover an agent which will destroy these bacilli without killing the person whom they attack. We do not know of anything by which the farmer can kill the weeds, but not the potatoes in his field; and in like manner, we can hardly expect to find an agent capable of killing the tubercle bacilli without injuring the human body. So we are obliged to seek a remedy for many diseases in a change of climate, and therefore every practicing physician should possess some knowledge of climatology. I have frequently met patients with advanced phthisis, away from all the comforts of home and its surround- ings, dying in a strange land, sustained only by hope, and the fact that they were carrying out the advice of their physician, who had not taken the trouble to look sufficiently into the matter to qualify himself to decide the important question, as to which particular climate or locality was most suited to his patient’s case. I wish I could adequately picture to you in words the many sad scenes I have witnessed. It is indeed a Very easy thing for the doctor, who probably knows that all hope is ended, and a fatal termination not very far dis- tant, to say to his patient, “Go to Europe, Australia or Southern California.” The poor unfortunate patient is at once inspired with hope, his weakened frame is sus- tained by will-power, and yet he scarcely reaches his destination before nature gives way. A long journey.” a surprising tax on the strength of even a healthy person. I am strongly opposed to the method adopted by ma"). of recommending places in a general Way, regardless of CLIMATOLOGY IN ITS RELATION TO DISEASE. 561 their individual characteristics. The benefits and dan- gers of the climate of a heaſth resort cannot be arbitra- rily stated, for the climatic conditions which constitute life to one invalid or class of invalids may be inimical to the well-being of another. There are, it is true, certain conditions equally desirable for all classes of cases, such as purity of the atmosphere and of the water, hygienic surroundings, and other circumstances, and these should be carefully considered in all cases. Residence in a suitable climate is an almost indispen- sable factor in the treatment, prevention, and cure of many forms of disease. Thus we constantly see invalids about us whose condition is critical, until they remove to a suitable climate, when their malady is cured, or, at least, so alleviated that life is prolonged for years, and they again become active, useful members of society. But some of these cases only continue to improve as long as they reside amid these congenial surroundings. The prescriber of climate must learn to individualise his prescriptions, not alone in regard to the disease, but more particularly in regard to the temperament of the patient and the nature and stage of his malady. When Contemplating a change of residence for an invalid, we are of course to keep in mind other equally important Conditions, such as rest, clothing, cuisine, nursing, con- genial company, avoidance of the excitement of fashion- able resorts, sanitary surroundings, etc. The latter, from my OWn Observation, receive about the least attention of them all. In many of our so-called health resorts, they have not the least conception of what constitute good Sanitary conditions; the water-closets are located very *the house, and the slops from the kitchen are thrown out of the door or window, upon the ground, without any *image but that which nature provides. This state of things exists, year after year, until the whole soil about the premises becomes thoroughly saturated. The place in other respects may be healthy enough, but if the house in Which the patient stops has improper drainage, little will 36 - 562 INEW YORK STATE MEDICAL ASSOCIATION. be gained by change of climate. It must also be remem- bered that a person with quiet tastes will not enjoy a gay place, and vice versa. Again, if one with moderate means visits an expensive place, the worry about pecuniary affairs will probably neutralise the good effect of climate. It is a matter of great importance for the invalid to seek the benefits of a change of climate at a sufficiently early stage of his malady to be really helpful. Nothing is more pitiful than to see a dying patient, or one who cannot be relieved or improved, expend his Small store of strength in a fruitless journey, and exchange his many home comforts for the discomforts which have to be endured by the sick when traveling. There are, however, many persons affected with chronic and incurable dis- eases, whose sufferings may be alleviated, and whose life may be prolonged by a residence in a suitable climate, and such should be encouraged to make a change. I shall make no attempt to describe transatlantic resorts, for our own country affords a sufficient variety and range of climatic conditions to meet the wants of any case where change of climate is desired. It seems wholly unnecessary for Americans to seek relief at the various resorts abroad, when in our own land they may enjoy an equally good, or even a Superior climate at the health resorts of the Adirondack Mountains, Southern Cali- fornia, Colorado, Asheville, N. C., the Cumberland range of mountains in Tennessee and Kentucky. While it is true that the Alps and the Pyrenees afford many attrac- tions, the resorts of Colorado and the Rocky Mountains compare very favorably with them in every respect. Many of the famous European Spas are but prototypes of more or less noted mineral springs in this country, which are numbered by hundreds. If our American people would more generally seek health in our own sanitaria, the value of these places would soon be appreciated, and their fame become widespread. For the American, the health stations of his own land are preferable, in that while he is seeking benefit from the change of climate, he CLIMATOLOGY IN ITS RELATION TO DISEASE. 563 is among his own countrymen, with familiar customs, language and diet, a truly important factor in the treat- ment of many diseases. In speaking of resorts, you may notice that I mention the Adirondacks first. I do this because of my personal knowledge of this region, and because I believe it more nearly, than any other section of our country, combines all that is desirable in a health resort to make it the most famous in the world. Another important advantage is its accessibility. In Southern California may be found many delightful seaside resorts. The most Southern of these resting-places is San Diego, situated only about fifteen miles from the Mexican border. It is a beautiful, flourishing city, and has the finest harbor on the Pacific coast, south of San Francisco. The climate is wonder- fully bracing and equable, the mean temperature being 62°, seldom rising to 80°, or sinking below the freezing point. The air is particularly dry, and free from the fogs found further north along the coast. The aver- age annual rainfall is about ten inches. The dry, spring-like climate all the year round has induced many invalids to locate here with their families, and, in time, they have been restored to health, and have become per- manent residents. Near here, across the harbor, is situated, on a peninsula, a new resort known as Coronado Beach. It has a fine sandy beach, and good surf bathing the entire year. This place is destined to rival other re- Sorts along the coast. For those who require a greater altitude, there is prob- ably no better place than the range of Rocky Mountains which passes through Colorado, for here is where they attain their greatest altitude, many peaks reaching a height of 13,000 or 14,000 feet above the sea-level. The mountain region of North Carolina, and the adjoining parts of South Carolina, Tennessee and Georgia, have many desirable resorts. The country has a delightfully Salubrious climate, in many respects similar to that of the White Mountains. It has an average elevation of 564 JNETW YORK STATE MEDICAL ASSOCIATION. 2,000 feet above the sea-level, and some of the peaks at- tain a height of 6,000 feet. Asheville, N. C., is in the centre of this region, and here the hotels are desirable and the scenery beautiful. It has a cool, dry climate, and is a favorite all-the-year-round resort. I wish now to call your attention to the Cumber- land range of mountains in Tennessee. I spent nearly two years in this region, and from personal observation can assure you it is well worthy of your consideration. I have witnessed here some wonderful recoveries. The late Dr. E. M. Wight has left a valuable contribution on this subject in an article startlingly entitled “A People Without Consumption,” in which he refers to the inhabitants of the table-land of Tennessee, on the Cum- berland plateau. He says: “During the ten years I had practiced medicine in the neighborhood of the Cum- berland table-lands, I often heard it said that the people of the mountains never had consumption. Such infor- mation came to me in such a variety of ways that I deter- mined I would investigate the matter. The observations extended over a period of four years, and were made with great care and with as much accuracy as possible, and to my own astonishment and delight I have become convinced that pulmonary consumption does not exist among the people, natives and residents, of the table- lands of the Cumberland Mountains.” In the perform- ance of the work which enabled Dr. Wight to arrive at this conclusion, he had the assistance of more than twenty physicians who had practiced for many years on the mountains. The facts seem all the more startling when one considers the diet of the native residents of the mountains. They live almost wholly on corn-bread, bacon, and coffee; all food is eaten hot, and coffee usually accompanies all three meals, and is drank with- out sugar or cream. A large majority of the adult population use tobacco in some form, the men in chew- ing and smoking, the women in smoking and dipping snuff. They very seldom have dyspepsia, and they never O'LIMATOLOGY IN ITS RELATION TO DISEASE. 565 grow fleshy after childhood, though nearly all the chil- dren are ruddy in appearance. Now, what classes of cases are mostly benefited by change of climate 7 I would answer, pulmonary phthisis, catarrhal affections of the respiratory organs, asthma, hay-fever, neurasthenia, debility, rheumatism, Bright's disease, hepatic disorders, scrofulous affections, and ma- larial troubles. In my experience, a pure, clear, dry, cool, rarefied atmosphere, with good electrical conditions, and plenty of sunshine, is desirable for most phthisical cases. Such a climate may be found in the Adirondacks. A mild and moderately dry climate is well adapted for some phthisical cases, and such a climate may be found in Southern California amid the most delightful sur- roundings. Of all the charming resorts in this region, San Diego and Coronado Beach deserve to be mentioned first, but Santa Barbara and Los Angeles are not far behind. Catarrhal affections of the respiratory organs are very favorably influenced by a change of climate, some cases being benefited by the dry, rarefied atmosphere of high altitudes, which stimulate the absorption of inflamma- tory products, while other cases are relieved by a resort to the Sulphur and Salme Mineral Springs. Sea air is especially applicable in some cases, and pine forests are also very helpful in certain cases. Few conditions are more favorably influenced by cli- mate than asthma, but it is a malady presenting so many forms that it is difficult to lay down any definite rules as to climate. Hay-fever is markedly relieved, if not com- pletely cured, by a residence in Southern California. The White and Rocky Mountains are also suitable places. Those suffering from nervous diseases more often re- quire change of scene, with congenial surroundings, than change of climate. Debility, though not in itself a dis- tinct disease, is a definite condition. These cases require the tonic, invigorating air of the mountains and sea. Rheumatism needs a climate free from sudden changes 566 NEW YORK STATE MEDICAL ASSOCIATION. of temperature, one with an abundance of sunshine, Sandy soil, and a high altitude; in short, perpetual spring. The nearest approach to this exists in Southern California. Sufferers from Bright's disease, hepatic, scrofulous and malarial affections all require about the same cli- matic conditions, namely: the bracing air of the sea and the mountains, with the use of alkaline and Salme min- eral waters. In a word, the paramount considerations for the promotion of health are abundance of pure air, sunshine, and outdoor exercise. Without these, no climate will restore the sufferer to health, but with them, wonderful results may be obtained. PEL WIC VERSION. By T. J. McGILLICUDDY, M. D., of New York County. Movember 15, 1892. The subject of version might, with advantage, be en- tirely re-written, for the text-books in use to-day give but a portion of the important facts connected with it, and it would well repay our writers on obstetrics to again carefully study and review this whole subject. I would divide version into three classes, which may be named in the order of their desirability and impor- tance as follows: (1) cephalic, (2) pelvic, (3) podalic. This is the ideal classification, and there can be but little doubt that it is the correct one. Pelvic, or breech ver- sion, is mentioned by some writers on obstetrics, but it is generally considered as synonymous with podalic ver- Sion, and the indications for its employment are not by any means well understood. Cameron, in the American, System of Obstetrics, says: “As the foetal ovoid has but two poles, the cephalic and the pelvic, the foetus must be turned to one or the other of them. When it is turned to the head the operation is called cephalic ver- Sion; when turned to the breech, pelvic version. Podalic Version, or turning to the feet, is a variety of pelvic ver- Sion, and should be classed as such.” The Operation of pelvic version has not yet been prop- erly described, and its advantages are known only to a Very few ; hence it has seldom been performed manually. Obstetric works rarely even refer to it, and if they do, half a dozen lines are considered sufficient space to devote to a description of it. This systematic neglect of Such an important operation seems to me a most unfor- tunate error, and one which should have been corrected long ago by practical obstetricians. 568 NEW YORK STATE MEDICAL ASSOCIATION. Spontaneous pelvic evolution (Figs. 1, 2, 3) is said to be of quite common occurrence, and I think it would be much more frequently observed if special attention were directed to it, and if obstetricians were not so prone to interfere with Nature’s methods. It is more easily ac- complished when pregnancy has only advanced to the seventh or eighth month, and it is possibly more common at this time than later on in pregnancy, when the child is larger. Welpeau cites one hundred and thirty-seven Fig. 1. Fig. 2. Fig. 3. cases of spontaneous evolution. Where the child is dead, and the shoulder low down in the pelvis, the uterine contractions, aided by the anatomical conditions present, readily cause the spine to become doubled on itself an- teriorly, for, the abdomen having no bony structure, and the spinal column no spinous processes in front, anterior flexion is easily effected. Spontaneous pelvic evolution is a more common occurrence than spontaneous cephalic evolution. The latter is quite rare, and is due to the same factors operating in the opposite direction. In spontaneous pelvic version the breech presents, while the head and trunk pass toward the fundus. This is of much more frequent occurrence than the preceding, but it cannot take place when the uterus is retracted and moulded to the foetus. The natural mechanism of PEI, VIO VERSION. 569 spontaneous pelvic evolution can be readily imitated by art, because artificial efforts tend to supplement and assist the natural ones; indeed, they follow in the line of Nature's method of delivery. Pelvic version in these cases is simply the imitation artificially of spontane- ous pelvic evolution, and is especially indicated in transverse presentations. This method of delivery, how- ever, has seldom been attempted by artificial means. According to Kleinwachter, it is indicated in cases where the pelvis lies nearer the inlet than the head does, and where cephalic version would be difficult, or impossible. It may be performed by external manipulation alone, but is more easily accomplished by the combined method. When this method is chosen, the fingers of the obstetri- cian should be inserted in the child’s groin, or over the crest of the ilium (Fig. 4), and the breech drawn down ºsts sºs NSR, Sº St. S. S. - N. § Fig. 4. into the pelvic basin. The operation of extraction can then be easily performed if the child be small; or, if large, and it has been decided not to wait for the natural delivery, the forceps may be applied to the breech. Spontaneous expulsion, as a result of the uterine con- tractions, may take place in transverse presentations Where the shoulder presents, and the body is fairly 570 JNETW YORK STATE MEDICAL ASSOCIATION. engaged in the pelvis. Denman cites several cases in which this has occurred, but we should not think of depending upon nature to effect delivery in this way. Where artificial delivery has been resorted to under these circumstances, it has been the custom heretofore to perform podalic version, but instead of this, I would recommend the performance of pelvic version. Its ad- vantages over podalic version in cases of transverse pres- entation may be summed up as follows: (1) It is a much simpler operation, as it simply con- verts the case into an ordinary breech presentation. 4. Fig. 5.—Pelvic Version. (2) It necessitates the introduction into the uterus of the fingers only, whereas podalic version requires the introduction of the whole hand and arm. (3) It is only necessary to move the child sufficiently to draw down the breech, while in most cases of podalio PEI, VIO VERSION. 571 version the body of the child must be made to rotate around the whole cavity of the uterus. (See Figs. 5, 6.) (4) There is much less risk of rupture of the uterus. (5) The operation is attended with much less shock. (6) For the foregoing reasons, the mortality for both mother and child is much less than in podalic version. : sº . : ! Fig. 6.—Podalic Version. Now, in podalic version (Fig. 6) the body and head must ascend to the fundus before delivery begins, thus making the circuit of the interior of the uterus. This does not occur in pelvic version, for the breech is drawn down at once, and in doing this it does not traverse, at the most, Imore than one-fourth of the circuit of the literine cavity. If the uterus be strongly retracted over the body of the child, podalic version is extremely 572 NEW YORK STATE MEDICAL ASSOCIATION. hazardous, both on account of the profound shock which it produces, and the great liability to uterine rupture. Podalic version is often of doubtful utility, and the writer firmly believes it has been elevated to a position which it does not merit. It is often employed for con- ditions in which the forceps or pelvic version is indicated, and its performance in cases where there is thinning of the lower segment of the uterus has been responsible for many deaths from shock, or from uterine rupture. In cases of transverse presentation, where the child is alive and movable, and no great force is requisite, ce- phalic version (Fig. 7) should be attempted in the inter- \ Fig. 7.-Cephalic Version. vals of the pains, while the uterus is thoroughly relaxed by means of morphia or chloroform. If this fails, it Will usually be found that pelvic version is practicable. If an examination during the last month of pregnancy shows that the presentation is not cephalic, it should be made so, and if during labor the presentation is found to be neither cephalic nor pelvic, the child should be immediately turned so as to make the case one of cephalic or pelvic presentation, and then this position PEI, VIO VERSION. 573 carefully maintained. In turning the child, the pressure should be made in such a way as to shorten the long axis of the foetal ovoid, and to place it in proper relation to the pelvis. Pressure should be made, therefore, exter- nally upon the head and breech, thus producing flexion, and approximating the two poles of the foetus. If this external manipulation be not successful, the external hand should be made to press the head and shoulder of the foetus upward, not too strongly, while the inter- nal hand draws down the breech. If much force be required, the breech may be drawn down by the thumb and two fingers of the Operator grasping the foetal pelvis, with their extremities on the iliac crests, or in the groins (see Fig. 4). After the completion of version, if immediate extraction be indicated, it may be accom- plished by continuing to make traction with the hand, or by using for this purpose the forceps, fillet, blunt hook, or, in some cases, my compression forceps. All this may seem very radical, but it is in the line of prog- ress. It is important not to confound version and ex- traction, for they are two distinct operations, and each has its own special indications. Pelvic version is especially useful in those unfavorable cases in which the arm presents, with the shoulder pressed well down into the pelvis, where the liquor amnii has been discharged, and the uterus is retracted on the child’s body. Here podalic version is usually out of the question. Podalic eatraction certainly has advan- tages which should be borne in mind, but it must not be Confounded with podalic version, which has been recom- mended for so many different conditions. The recent additions to our knowledge, derived from abdominal palpation, and the other improvements in obstetrical Science, lead me to believe that it is far from being a panacea for all obstetrical ills; indeed, I think that it is rarely necessary. In a pelvis of fair dimensions and with a child of moderate size, pelvic version is not a difficult Operation, and when carefully performed, there will 574 NEW YORK STATE MEDICAL ASSOCIATION. rarely, if ever, be any need for decapitation or eviscer- ation. The following case, which is illustrative of a large class, will, I think, serve to show the indications for pelvic version : Mrs. W., twenty-five years of age ; the wife of a physician. Her first pregnancy was normal, and nothing unusual occurred during the second pregnancy until the ninth month was reached, when an accidental blow on the abdomen caused slight uterine haemorrhage, which lasted for a few days, and was followed by labor, pains. On examination, her husband found a dorso-anterior transverse presentation, which he attempted to rec- tify under chloroform by performing podalic version. Owing to the de- velopment of some alarming symptoms, he desisted, and gave her some Magendie's solution, to quiet the pains, pending my arrival. I found the patient well narcotised, and the uterus completely retracted on the body of the child. The patient had had more or less pain for two days. The left arm of the child and about two feet of the umbilical cord protruded from the vulva. The hand and arm were bluish and swollen, and the cord was cold and pulseless. Owing to the retraction of the uterus, and the moulding of it to the body of the child, ordinary podalic or cephalic ver- sion was, of course, inadmissible. As the head of the child lay toward the right, I introduced my right hand, slipped my fingers into the child’s groin, and brought down the breech, following Nature's method. I was in this way able to quickly and easily effect delivery. (Fig. 5.) DISCUSSION. DR. OGDEN C. LUDLow, of New York county, said he had had no per- sonal experience with pelvic version, and had hitherto held the opinion that its sphere of usefulness was quite limited, being confined to those cases in which the pelvis was relatively large; but, taking into consideration the great flexibility of the vertebral column in the foetus, together with the as- surance of the author, that this method of delivery is quite easy, it seemed worthy of more extended trial. He had been particularly impressed by the author's statement as to the limited arc the foetus describes ºn uté?'0 during the performance of pelvic version, as compared with that described in podalic version, and this alone would be a decided point in favor of pelvic version, as it greatly diminishes the tendency to shock and to rupture of the uterus. - DR. M. C. O’BRIEN, of New York county, said that apropos of What the author had said about prompt delivery, he would like to relate a Case in which, for the time being, he was puzzled to know just what to do. A young woman, twenty-eight years of age, was leaning out of the window, when the amniotic fluid suddenly escaped, and strong uterine contractions DISCUSSION. 575 set in within an hour. Examination per vaginam showed the foetus to be lying in an abdomino-anterior position, so that the hand, cord and foot all presented at once. During this examination there was a sudden snap, and a gush of blood, showing that the umbilical cord had ruptured. The end of the cord was grasped by the finger and thumb, and an effort made to perform bimanual version, as the child's life was in great danger, and speedy delivery was demanded. With some difficulty, owing to the violent contractions of the uterus, one foot was made to slip down alongside of the right wrist. This was grasped, and slight traction made until the umbili- cal cord could be reached with the left hand. Then, after changing hands, as the external One was cramped, the Stump of the umbilical cord was grasped in the left hand, and with the right hand gently pressed into the groin of the child, he was able to deliver the child without bringing down the other foot. On delivery, the child cried lustily. The stump of the cord was transfixed with a needle, and tied. The delivery of the placenta was followed by the discharge of many large clots of blood, showing that the placenta had been partially separated at the time of the rupture of the cord. She would have delivered herself, in all probability, as sixteen months before he had arrived at her bedside just in time to see the breech of the child come into the world ; but in this case a moment's hesitation would have sacrificed the child’s life. The child was certainly delivered by pelvic version. SHOULD WE TREAT FEVER, 7 By S. T. ARMSTRONG, M.D., of New York County. (Read by title November 17, 1892.) It is almost unnecessary to offer any excuse for pre- Senting for your consideration so familiar a topic as is fever, because, as frequently as it is encountered in the routine of our daily work, it is nevertheless surrounded by some of the most abstruse problems in medicine, when we consider its etiology and treatment. More than six hundred different names are given under the caption “Fever,” in Foster’s Encyclopaedic Medical Diction- argy; and although many of these may be appellations for the same disease, still their number affords an idea of the multifarious phases in which fever is encountered. Pathologists and clinicians have not yet agreed regard- ing the cause of the manifestation of fever in the animal organism. The late Austin Flint, in an address delivered before the Ninth International Medical Congress," said that “an essential fever is an excessive production of heat in the body, induced by a special morbific agent Or agents, and due to excessive oxidation, with destruction of the tissues of the body, and either a suppression or a considerable diminution in the production of water.” He intentionally ignored the causative influence of the nervous system. W. H. Welch showed in his Cartwright Lectures” that the most frequent cause of fever was some substance that exerted a pyrogenic effect when intro- duced into the circulation, so that it could act in Some way upon the nervous system. Welch considered that if 1 The Medical News, September 10, 1887. * The Medical News, April 7, et seq., 1888. SHOULD WE TREAT FETVER 9 57.7 it was assured that these substances incited directly in the blood and tissues chemical changes that led to an increased production of heat, it was even then necessary to have recourse to some action that was exercised upon the nervous system, in order to satisfactorily explain the phenomena of fever. Samuel' defines fever as an eleva- tion of temperature that is evoked in consequence of a lesion of the heat-centres. Donald Macalister, in his work on the nature of fever, expressed the Opinion that physiological and pathological experiments had showed that pyrexia depended upon an impairment of the inhibi- tory force, by which the heat-producing process is kept within normal physiological grounds, that is, impaired thermotaxis; upon an increased activity of the process by which the heat is naturally formed, that is, exalted thermogenesis; and upon a more or less complete failure of the process by which heat is discharged, that is, a failure of thermolysis. If we accept this latter explana- tion and each year’s discoveries add force to the reasons now existing for such acceptance, the infection of the blood by any organic product is simply the means of reaching the nervous centres, thereby producing the phenomena of fever. It must be stated that this theory is not universally accepted, Professor Årnaldo Cantani believing” that fever is an acute alteration of organic metabolism, with increase of tissue combustion, thus agreeing with Flint, though overlooking Welch’s warn- ing that even with this theory, it was necessary, in the last analysis, to have recourse to the action of the heat- Centres. Most clinicians accept fever as the principal index of the course of an infective process in the animal organism; and the question must be decided, in each case of fever, Whether the infection is autogenetic or heterogenetic. we know that certain poisons, such as strychnine, vera- trine, nicotine, and picrotoxine, will produce fever when * Real Encyclopädie der gesammten Heilkunde, article “Fieber.” "Transactions of the Tenth International Medical Congress, Vol. i., p. 152. 37 578 NEW YORK STATE MEDICAL ASSOCIATION. given in certain doses. In certain digestive disturbances the peptones formed during digestion may gain access to the general circulation, and produce an autogenetic in- fection fever, analogous to the ferment fever Hildebrandt has produced in dogs by the subcutaneous injection of pepsin. Vaughan and Novy have called attention" to this intra-organic formation of poisons, and they em- phasise the importance of the subject by saying that “a man may drink only chemically pure water, eat only that food which is free from all adulterations, and breathe nothing but the purest air, free from all organic matter, both living and dead, and yet that man’s ex- cretions would contain poisons.” They consider that it is unimportant whether the proteid molecule is broken up by organised ferments (bacteria), by unorganised fer- ments (the digestive juices), or by those unknown agen- cies that induce metabolic changes in the tissues, for, in all cases poisons, differing in quality and quantity ac- cording to the proteid that is acted upon, will be formed. These poisons produce the autogenous fevers known as fatigue, exhaustion, thermic, non-eliminative, nervous, and hysterical fever. Whatever cause may produce the fever, there is always an increased temperature that physiologists have shown is due not merely to a diminution of the loss of heat, but chiefly to an increased production of heat, as calorimet- ric observations have proved. Increased heat production alone would be insufficient to raise the temperature of the body if there were a compensating increase of loss of heat; but this compensation is wanting in fever, and it has been designated the most characteristic feature of the febrile condition. Besides the ataxia of the thermal centres, there are increased metabolism, as is evidenced by the augmented excretion of carbon dioxide, of urea, and the other urinary products; great frequency in the number of the heart-beats, and in the respiration; dimi- nution of the digestive activity and intestinal move- * Ptomaînes and Leukomaînes, Philadelphia, 1891. SEHOULD WE TREAT FE VER 2 579 ments; and general disturbances of the organic func- tions. * From this resumé of the febrile phenomena, it may be deduced that pyrexia, as seen by the physician, is the expression of certain pathological processes that inter- fere with the physical and mental welfare of the person affected, and that consequently demands treatment. When those interested in the history of medicine read the works that served to illuminate and instruct our pre- decessors of the first half of this century, and learn there- from the then prevalent practice of starving the fever patient, they will entertain a high regard for Dr. Graves, whose teaching assisted in securing the abandonment of this practice, and who said the only epitaph he desired was: “He fed fevers.” And while there may be una- nimity of opinion regarding this point, the physician is confronted in this fin de siècle by another problem that Cannot but be an absorbing one, for there are those who urge, though they may not seek epitaphic renown, that there should be no treatment for fever per se. Are we to throw, so to speak, our antipyretics to the dogs' Is fever a beneficial organic reaction to the metabolic and haemic changes produced by the causative agent of the disease? Osler, in his recent work on the Practice of Medicine, says: “Fever alone is not hurtful, but it is difficult to differentiate the effects of fever and of the poisons circulating in the blood. It is not impossible, as Some Suppose, that the fever may be directly beneficial; still, high and prolonged pyrexia is undoubtedly dan- gerous, and should be combated.” And Lyman in his more recent work on the Practice of Medicine, says: “The elevation of temperature that marks the course of fever is not an unmixed evil, yet it is customary to attempt its reduction.” Each of these authors seems to have accepted the fever process as explicable by the seemingly fantastic German theory of the day, that fever * in the nature of a reparative process. In just what Way it is reparative we are not informed; and it is as 580 NEW YORK STATE MEDICAL ASSOCIATION. impossible to say with our present knowledge, in exactly what way fever accomplishes any useful purpose, as it was when Welch published his classic study on the sub- ject of fever. The conclusion formulated by Austin Flint in the address heretofore referred to, that “the abstraction of heat by external cold, and the reduction of temperature by antipyretics administered internally, without affect- ing the special cause of the fever, improve the symptoms which are secondary to the pyrexia,” expresses the practice and belief of most physicians. Reference has been made to the influence of certain alkaloidal poisons in increasing the temperature, pre- sumably in consequence of their effect upon the heat- centres. But recently Dr. E. Maurel has published" a series of experimental researches on the action of these alkaloids on leucocytes, and he finds that the toxic action of the alkaloids on the animal economy is in the ratio of its destructive action on the leucocytes. For example, five centigrammes of Strychnine will immediately kill all the leucocytes in one hundred grammes of human blood, while two centigrammes of that drug will effect the same result in the same quantity of blood in several hours. Five centigrammes of atropine would also instantly kill the leucocytes in one hundred grammes of human blood; although in the blood of the hare, an animal that eats belladonna with impunity, the alkaloid was almost with- out effect upon the leucocytes in the strength of tWO grammes of atropine to one hundred grammes of blood. Pilocarpine kills the leucocytes in human blood in a dose of ten centigrammes to one hundred grammes of blood. These experiments forcibly demonstrate the important relation existing between the leucocytes and the func- tions of the organism, and give force to Metschnikoff's theory of the relation between phagocytosis and im- munity from disease. If these drugs that may produce fever are toxic to the leucocyte, should our treatment of 1 Bulletin de Thérapeutique, 1892, czzii., p. 259. SHOULD WE TREAT FETVER 2 581 fever have in view the preservation of the leucocyte under the best conditions, because in fever we have poisoning by animal rather than vegetable alkaloids? The experiments that were made with the product of the tubercle bacillas are not so old that we have forgot- ten the fever that soon followed the hypodermatic injec- tion of a small quantity of tuberculin. The injection of the product of the cholera spirillum is also followed by fever, a result that is subsequent to the hypodermatic injection to the products of several of the infectious microörganisms. Such a fever, though usually enduring only a few hours, may be sustained by repeated injections of the toxine product employed. It is therefore apparent that the microörganism causes fever by the production of its leucomaine or toxine, rather than by the presence of the organism itself in the body. It is possible to adduce further evidence of the influence of the increased toxicity of the blood in producing disturbances of the thermal centres, just as an analogous autogenetic increase of the toxicity of the blood-serum causes disturbances of the convulsive centres. The recently published experiments of Bouchard have shown, that during puerperal convul- Sions the urine is diminished in quantity, and that it is less toxic than usual, so that no effete products that should be excreted, are retained in the animal organism. Dr. Chambrelent has proved" the latter statement to be a fact, by supplementing Bouchard’s experiments with the urine, by those he made with blood-serum that he also Obtained from women suffering with puerperal eclampsia. Chambrelent's results showed that the poisonous prop- erties of the serum were constantly related to the gravity of the case, so that increased autogenetic infection aug- mented the severity of the convulsions. . The high temperature of fever cannot exercise a fatal influence on the specific microörganisms with which we are acquainted, because they develop most favorably at a temperature of from 35° to 40° C., so that the usual * Lancet, September 24, 1892. 582 JWEW YORK STATE MEDICAL ASSOCIATION. febrile temperatures are best suited to their growth. This would seem as if fever were more useful to the micro- than to the animal organisms. Robert Koch regards temperature as the most important factor in the process of attenuation of the microörganisms, the temperature effect being aided perhaps by certain products of tissue- change in the bacilli. That these latter products are the more important in producing this attenuation, is shown by the existence of the cholera spirillum, the typhoid bacillus, and other specific microörganisms in the tissues of persons affected by those infectious diseases, after all febrile phenomena have ceased. The brothers Klemperer have shown that in animals inoculated with the pneumococcus, temperatures varying from 40° to 41° C. were reduced to normal in twenty- four hours after the injection of serum from another animal that possessed immunity from pneumonia. They believed that the pneumococcus generated in the animal organism a product that they called pneumotoxine, that produced elevation of temperature; the pneumotoxine in its conflict with the leucocytes generated an anti- pneumotoxine that neutralised both the pneumotoxine and the pneumococcus. They injected the blood-serum of persons convalescent from pneumonia into six pneu- monic patients, and in from six to twelve hours subse- quently, there was a decided fall of temperature that remained normal in two of these patients. - Metschnikoff, Golgi," Gamaleia,” and Laveran” agree that fever acts like artificial heat in increasing the activ- ity of the leucocytes, so that the parasitic elements be: come more easily their prey than they do in an individual in whom the temperature is normal. Metschnikoff' states. that in relapsing fever the febrile access lasts during the free life of the spirilli in the blood, and ceases when these parasites become the prey of the leucocytes. 1 Phagocytisme dans le Paludisme. * Annal. de l’Instit. Pasteur, 1888, p. 229. * Traité des Fièvres palustres. 4 Annal. de l’Instit. Pasteur, 1887, p. 329. SHOULD WE TREAT FE VER 3 583 Here again we see the disposition to make the fever a reparative process; and yet clinical and experimental facts do not wholly warrant the deduction. In the ex- periments of the Klemperers, above cited, the fever was insufficient to increase the leucocytic activity to a degree that disposed of the pneumococcus and prevented the formation of more pneumotoxine. It had been proved that the latter by itself caused fever; therefore, it is a justifiable inference that the persistence of fever for from six to twelve hours after the injection of the serum from the pneumonic convalescents, was due to the pneu- motoxine present in the blood at the time the injection was made ; and the subsequent decrease in temperature was caused by the destruction of the pneumococci by the serum, and consequent cessation in the formation of pneumotoxine. In paludal poisoning the fever persists or recurs as long as Laveran’s haematozoa are in the blood. Quinine has no special influence in inciting leucocytic activity, at least as a principle applicable to all diseases. Yet the administration of quinine, by destroying the specific Or- ganism of paludal disease, ends the fever that never plays the rôle of a reparative process therein. Opposed to this deduction are the experiments of Alexander" that showed that the number of spirilli in re- lapsing fever increased when the temperature of the affected person was lowered by antipyrin. Wagner” showed, as Pasteur had shown before him, that fowls exposed to cold became capable of acquiring charbon ; he considered that this occurred in them because the leucocytes lost a portion of their activity, and he was able to produce the same effect by lowering the tem- perature of the fowls by antipyrin. Professor A. Rovighi, in the reports of the results of his experiments made to determine the influence of * Bresl. firzt. Zeitschr., 1884, Nov. 11. * Ann. de l’Instit. Pasteur, 1890, p. 571. * Le Mercredi médical, August 3, 1892. 584. NEW YORK STATE MEDICAL ASSOCIATION. artificial elevation and depression of temperature upon the course of infective processes, stated that he inocu- lated rabbits with human saliva that was poisonous for these animals; he placed some of them, together with uninoculated rabbits, in a thermostat in which the tem- perature oscillated between 36° and 40° C. Other inocu- lated rabbits were kept in ordinary cages, while still others were placed in cold chambers and in cold baths, in which their temperature did not exceed 40° C. Death occurred earlier in the latter animals than in those in the thermostat; in fact, these latter died more slowly than those in the ordinary cages. But if the temperature of the rabbits in the thermostat exceeded 43° C., death occurred quickly. Elevation of temperature occurred much more rapidly in the infected than in the uninfect- ed animals in the thermostat. The loss of weight was much greater in the animals kept in a lower than in those in a higher temperature. At the point of inoculation in the latter, there was an abundant fibrinous exudate COn- taining a large number of leucocytes, while in the re- frigerated animals the exudate was sero-purulent and less rich in leucocytes. The blood of the animals in the thermostat was much more toxic than that of those re- frigerated, evidencing an increased formation of toxines in the former ; though cultivations succeeded better if made from the blood of the refrigerated animals, because it more frequently contained the living microörganism. Rovighi also inoculated rabbits with mouse septicaemia; and those to which he subsequently gave acetanilid rapidly succumbed to a considerable decrease of tem- perature, while those placed in a thermostat and in- fected in the same way, presented no other morbid phenomenon than an induration at the point of inocu- lation. He also found that rabbits and guinea-pigs inoculated with charbon, survived longer if kept at a high than at a low temperature, the charbon bacillus appearing later in the blood of the former than in that Of the latter. SHOULD WE TREAT FE VER 2 585 Walter published" the results of experiments on the effects of artificial elevation of the temperature of the body on the course of infection with the pneumococcus, in which he found that high temperature prevented its passage into the blood. While it appears to follow from these experiments, that an elevation of temperature to a certain degree exer- cises a favorable influence upon the infected animal, and that a lowering of temperature increases the intensity of the infective processes, it must be remembered that these are extraneous influences, while fever is an intrinsic influence. The observations of Röhrig and Kuntz, Colo- Santi and Kukler, Theodor, and others, have shown that gaseous exchange, and particularly tissue-oxidation in febrile animals, are much more intense in those exposed to cold than in those kept in thermostats. Yet these results are at variance with clinical facts, for, it cannot be denied that the best results in treating typhoid fever have been obtained by the use of cold baths that keep the temperature below 40° C.; and if these increase the intensity of the febrile process and of tissue-oxidation, We are led to believe that the patients of those who use them, recover in spite of, rather than on account of, the treatment that is only useful in increasing the elimination of toxic products. The researches at Penro have shown that karyokinesis and the regeneration of tissue are affected much more rapidly at a temperature of from 34° to 38° C. than at a temperature of from 7° to 12° C. But it has not been shown that karyokinesis and tissue-regeneration are af. fected at a temperature of from 38° to 40° C., as well as at the lower temperatures that antipyretic treatment en- deavors to Secure, and never does that treatment seek to reduce the temperature below 37.2° C., at which, experi- ºnent has shown, these processes are most effectively per- formed. If the statements that “fever alone is not hurtful,” or *Archiv für Hygiene, 1891, Bd. xii., p. 329. 586 NEW YORK STATE MEDICAL ASSOCIATION. that “fever is not an unmixed evil,” are based on the production of artificial fever in animals by inoculation, it is necessary to remember that in the latter, such a fever only reaches a temperature of from 18 to 4°F. above the normal temperature of the animal. And if based on the fever produced by prolonged confinement in thermostats kept at high temperatures, the animal’s temperature in such instances was only 4° to 5° F. above the normal. Such rises of temperature are not regarded with any alarm when they occur in man ; but while we may not look upon them as intrinsically hurtful or evil, they cer- tainly cannot be regarded as beneficial or good. A fair analogy to the treatment of moderate rises of tempera- ture is that of the treatment of pain. Each condition is indicative of irritation of certain portions of the nervous system ; and though it has been maintained that pain is beneficial, it is the popular plan to relieve it at Once whenever it appears, subsequently attending to the dis- turbing factor, of which the pain was the index. So, I believe, we should deal with fever; relieve it by suitable antipyretics whenever it appears, and then give those remedies that will eliminate the exciting cause. In this review of the question, whether it is desirable to relieve pyrexia by the administration of antipyretics, the following points have been held in view : 1. That fever is the expression of some disturbance of the thermal centres. 2. That while this disturbance may be traumatic, it is usually the result of the existence in the organism of certain autogenetic or heterogenetic (infectious) prod- ucts, that have the same affinity for the thermal Centres that certain vegetable alkaloids have for certain cerebral Centres. gº 3. That fever does not exercise any beneficial effect in limiting an infectious process; this is a fact that has been known clinically for years, by the occurrence Of cases of infectious diseases that pursued their usual course without any rise of temperature. SHOULD WE TREAT FETWER 9 587 4. That it is the general experience of clinicians that the relief of fever exercises a beneficial influence on the general condition of the patient, though the apyrexia does not indicate that the cause of the pyrexia has been removed. 5. That in many febrile conditions the causative prin- ciple has produced a thermotoxic paresis that is at once relieved by some suitable antipyretic. 6. That in continuing the employment of antipyretics we are not losing sight of the possibility of obtaining, either synthetically or derivatively, compounds, that will, when administered in the specific diseases, have the same inhibiting influence on the further development of the microörganisms of those diseases, that certain alex- ins, toxalbumins, or toxines possess. The action of such compounds should be as specific in each infectious dis- ease, as is the action of quinine in paludal fevers. BRIEF COMMENTS ON THE MATERIA MEDICA, PHARMACY, AND THERAPEUTICS OF THE YEAR ENDING NOVEMBER 1, 1892. ALPHABETICALLY ARRANGED. By E. H. SQUIBB, M.D., of Kings County. (Read by title November 17, 1892.) No other preface is needed than to repeat the introduc- tion of last year, that the aim of this brief commentary is to give a short, compact digest of the prominent cur- rent literature of the professions of pharmacy and med- icine. There has been no attempt made to treat the Sub- ject exhaustively by noticing every article written upon, but an effort has been made to give only such informa- tion as will be of some interest to readers, both in the way of furnishing a ready index of passing articles in Materia Medica and Pharmacy, and also as an abstract of what has been accomplished in Therapeutics during the year past. + The alphabetical arrangement is intended, of course, to aid in easy reference to any individual article. Acacia, or true gum Arabic, is now obtainable again by reason of the somewhat more settled condition of Egyptian affairs and the reopening of the Soudan—the chief source of our supply. It is just a little over ten years since the true gum ceased to find its way freely to our market. The cessation of this supply called forth an abundance of very fair gums from many quarters, in- cluding some localities from which it had never been even suspected good gum could be furnished. Still they were all inferior to the true gum Arabic. Many gum substi- tutes were manufactured and processes devised for rendering the gums soluble, which were obtained from MATERIA MEDICA, PHARMACY. THERAPEUTICS. 589 localities where plenty could be procured, but if taken as found, were useless because insoluble. None of these, however, could take the place of the true gum for many pharmaceutical and mercantile uses. We should now be able to have in future not only more satisfactory “gum drops,” but more elegant, useful, and cheaper preparations into which the true gum enters. Acetanilid (Antifebrin), prepared by the action of strong acetic acid upon aniline, still retains its position as an effective and reasonably reliable hypnotic and analgesic. Its antipyretic action continues, as last year, to be less reliable, and at times has produced a sub- 'normal temperature. Dr. H. E. Garrison, of Dixon, Ill., reports satisfactory results in the treatment of all cases of scarlet fever for more than two years past." Its use still furnishes many toxic symptoms. It is reported that during the last epidemic of influenza in Sweden, there were a great many poisoning cases—all recovering, however. This was largely due to the pro- miscuous and extravagant abuse of the drug. It fortunately continues to act well, almost univer- Sally, when given to children, but in all cases overdosing must not be practiced. Acid Agaricic (Laricic Acid) is gradually growing in usefulness, particularly among continental and English |practitioners, although still little is published concerning it in our own country. Its effect appears to be very Pronounced in checking most forms of sweating. The night-sweats of pulmonary tuberculosis continue to be effectually abated by it, and its use has been extended to cases of sweating in other affections. - As reported from some quarters, it appears to be necessary to obtain the acid from the true white agaric from the Polyporus officinalis (Agaricus albus), and not from the “fly agaric” or Muscarine (Agaricus Mus- Caria), as Dr. C. Basil Richards, of Tottenham, England, * N. Y. Med. Record, Wol. 42, p. 481. 590 NEW YORK STATE MEDICAL ASSOCIATION. believes what has been noted by others, that the action from the latter is exactly opposite. Dr. Richards has found the true acid very valuable in checking persistent Sweating from any cause, and in mentioning its marked effects in the sweating after influenza, he takes occasion to state that he has had only one case in which it failed throughout an experience of over two years. He men- tions the article he used as agaricin, but this is a term formerly applied to the agaricic acid which Martindale found to contain about three per cent. of the physiolog- ically inert Agaricol. The term agaricin, although less exact, is still retained by some. Acid Camphoric is deservedly gaining in popularity with the medical profession, both here and abroad. It has not only been in increasing use in the affections before alluded to, but has been used largely just as aga- ricic acid, the article last spoken of, in the treatment of sweating from various causes. The fact of its being very quickly and abundantly eliminated by the urine has been emphasised by nearly every writer, and attention is called to the necessity of giving it not more than two hours before the expected sweating is to occur, in order to Ob- tain effective results; and then relief, either partial or complete, may be looked for almost universally. Dr. James Wood, of Brooklyn, has had a number of very successful results in cases of tuberculosis where the sweating was profuse. He recommends giving it dry On the tongue as the best method. His article deserves reading." Good results continue to multiply from its use as an intestinal disinfectant. Acid Carbolic (Phenol) still holds prominence over its many and increasing rivals. The reddening of the acid still occurs, is still unaccounted for satisfactorily, and still continues to show no deleterious effects from this small amount of color. None of the synthetical methods which gave alleged promise of remedying this defect, 1 The Medical News, Wol. 60, p. 293. MATERIA MEDICA, PHARMACY. THERAPEUTICS. 591 have accomplished the desired result, nor can they Com- pete at the present time in economical manufacture with the extraction from the coal-tar products. During the past year a new series of derivatives of this acid has been produced from essential oils, and patented in Germany; they are claimed to be odorless, tasteless, neutral in reaction, and to cause no irritation. These derivatives when obtainable will have to be closely studied thera- peutically, and we may then hear of them under some new trade name which has not been applied as yet. Increasing beneficial results have been obtained from carbolic acid when used as a local anaesthetic in den- tistry, subcutaneously in some severe cases of tetanus, and in the form of subcutaneous injections of a strong solution into the region of a joint—close to the Synovial membrane—in cases of articular rheumatism. Acid Cresotic (Paracresotic Acid) has increased in medicinal value in the past year, as is evident from the accumulating favorable results from continental observ- ers. Practically nothing has been published as yet in this country. Abundant evidence now goes to prove what was pretty well established a year ago, that it is abso- lutely necessary that the paracresotic acid only be used. In the form of the sodium paracresotate, it has proved itself a safe and reliable article to use, especially with children. Professor Demme has employed this salt in the Jenner Hospital in Berne, and his records show good results in acute articular rheumatism, catarrhal pneu- monia, gastro-intestinal catarrh, and typhoid fever. As an antipyretic, it was found to be inferior to salicylic acid, but it was better tolerated by the digestive organs, and did not produce the congestion salicylic acid some- times causes. In the typhoid fever cases it checked the diarrhoea very markedly. Young adults may be safely given as much as 4 grammes (60 grains) daily. Acid Hydrocyanic Diluted (Prussic Acid) has still failed to be permanently preserved from decomposition, either by the use of various solvents, other than distilled 592 JNETW YORK STATE MEDICAL ASSOCIATION. water, or by the addition of preservatives. Scrupulous cleanliness in the mode of preparation and in the con- taining packages, alone gives fairly satisfactory results for at least a year. Acid Pyroligneous (Crude Acetic Acid), sometimes called Wood Winegar, is the crude product obtained from the destructive distillation of wood. It is a dark- brown liquid, almost black, the color depending largely upon the amount of tar contained in it, with a charac- teristic, not unpleasant, smoky odor. The tar would, of course, be practically insoluble in water simply, but the acetic acid present renders it perfectly soluble, and the whole product will permit of very considerable dilution with water before the tar is precipitated. This solution of the tar, no doubt, lends additional efficiency to the product. - Some attention has been paid during the past few months to this acid, with the idea of increasing its use as a disinfectant. From the acetic acid and other anti- Septic hydro-carbons which it contains, it should prove Of positive value, whilst from its great abundance, as a by-product, wherever wood is burned for the charcoal and wood spirit, it is everywhere accessible at very low cost. The fact that it can be used with perfect safety, and that it is always at hand when needed, will make it the more acceptable should its efficiency be proven. Acid Salicylic is still under critical investigation, particularly by the pharmaceutical chemist. A year ago the impurities were alluded to, and the marked differ- ence in therapeutic effects between the “natural” and the “artificial” acid. It was argued by some that there was so great a difference between the two that the “artificial” should be interdicted, as there was little chance of being able to bring the latter to the purity of the “natural.” It has now been proven by two English chemists, after careful experiments on the melting points of the two acids and their fractionation from the stable silver salt, that cresotic and other allied acids can be MATERIA MEDICA, PHARMACY, THERAPEUTICS. 593 completely separated from the “artificial” acid. It is then shown to have identical properties with the “natu- ral.” It now only remains for the objectors to the “artificial” acid to prove that the adverse therapeutic effects claimed are caused by these allied acids occurring in the “artificial” product, to give satisfactory and sufficient cause for insisting on the use of the far more expensive “natural” product. Although at times there have been many almost decisive reasons, given by ap- parently convincing therapeutic results, for taking this step, still the fact has not become sufficiently well estab- lished yet to offer for sale only the much more costly article, as the above proof has not yet been substantiated by close clinical observations. Acid Tartaric has recently been studied by M. Gen- resse, a French chemist, in the direction of discovering, if possible, the exact method of its formation in Nature. The London Lancet" gives a condensed abstract of his observations, showing the simple way in which it may be Synthesised, and it may be of passing interest to repeat the substance of the abstract here. He starts with gly- Oxalic acid—an acid found in gooseberries, grapes and other fruits—and acting upon it with nascent hydrogen liberated from a mixture of zinc dust and acetic acid, Obtains eventually tartaric acid, or rather the optically inactive form of it known as recemic acid, equal mole- cules of the dextro and laevo varieties being apparently produced. Upon examination of the formulae of gly- Oxalic and tartaric acids, it will be readily seen that the latter simply contains two molecules of the former joined together by two atoms of hydrogen, so that it is merely a question of bringing the two molecules together by hydrogen to produce the latter. It is well known that oxalic acid is formed most readily in vegetable tis- Sues, and is closely related to glyoxalic acid. Having regard, therefore, to the reducing tendencies which are known to characterise chlorophyll, it is not improbable * Vol. I. for 1892, page 764. 38 594 NEW YORK STATE MEDIOAL ASSOCIATION. that the natural building up of tartaric acid may be thus explained. Agathin (Salicyl-Aldehyde-o-Methyl-Phenyl-Hydra- zone) is a new synthetic compound discovered by Dr. Israel Ross, of Frankfort-on-Main, Germany, and found applicable in neuralgia and rheumatic conditions. It is prepared by the condensation of Salicyl aldehyde with a-methyl phenyl hydrazin. It occurs in Small, faintly green, plate-like crystals, without Smell or taste, and insoluble in water. It is recommended in doses of 325 to 650 milligrammes (5 to 10 grains) two or three times a day. It is necessary to wait a few days after continuous administration for beneficial action to manifest itself. Dr. E. Rosenbaum has had very favorable results in an obstinate case of sciatica. Other observers also report favorably in articular rheumatism. The maximum dose apparently produces headache for a limited period. The reports all come from Germany exclusively, as none of this compound has yet appeared in this country Or elsewhere. Amido-Eugenol Acetate is about the newest anaes- thetic introduced—originating from a German chemical firm, who have, of course, patented the process of manu- facture. Apparently this firm has deviated in this case from the usual practice of giving a short name to their compound for every-day use. It comes in the form of a fine powder prepared by the action of a solution of ammonia in alcohol upon eugenol-aceto-ethylic ether. It appears to be a local anaesthetic to mucous membrane. It is simply a novelty at this time, awaiting its fate. Amylene Hydrate (tertiary Amyl Alcohol) has not received altogether as favorable reports as a year ago. The Journal of Mental Science gives the results of four- teen cases of chronic epilepsy treated with this drug by Dr. Dunn. Although at first beneficial effects appeared to follow its use, it really seemed to have no advantage whatever over the bromides, which were used in parallel cases; and, again, the bromides were much cheaper. MATERIA MEDICA, PEIARMACY. THERAPEUTICS. 595 Analgen (Ortho-Oxy-Ethyl-Ana-Mono-Acetyl-Am- ido Quinoline) is one of the most recent analgesics. The chemical name is here purposely extended to an extreme by hyphens to assist in deciphering the component parts as well as to aid in the effort of pronunciation. It orig- inated from the almost universal source of such organic compounds—from Germany. Its synthetic composition was thought out before actual production of the Com- pound was attempted, and knowing the activity of the combining agents, the aim was to produce a substance of high physiological power by introducing a definite group of molecules having known pyretic action. The process of its production is too technical to be of interest here. It is a white crystalline powder in the form of delicate needles, only slightly soluble in water. It has been tried in 1 gramme (15 grains) doses in various rheumatic affec- tions with gratifying results, but it will have to make a history for itself. Antikol is a very new proprietary antipyretic mixture, which consists of 75 per cent. of acetanilid, 17.5 per cent. of Sodium bicarbonate, and 7.5 per cent. of tartaric acid. The proprietors charge from five to six times the price of the separate ingredients, and trade on the newness of the name and the prevailing gullibility of the public to further the sale of their mixture. Antinervin—the mixture of 50 per cent. of acetanilid, 25 per cent. of salicylic acid, and 25 per cent. of ammo- nium bromide—is now reported to have a much wider field of usefulness than a year ago. Observers give good reports from England, Germany and Italy. In Glasgow, Scotland, it attracted much attention in the recent epi- demic of influenza. It nearly always relieved the pains in the back and head, and rapidly reduced the fever. It Produced copious perspiration and no unfavorable effects. Pr. G. Laurenti, of Italy, now summarises his own Personal experience: 1. It can be used with advantage ºn all forms of abnormal excitement of the nervous Sys- tem, whether to subdue neuralgia or as a general nerve 596 JNEW YORK STATE MEDIOAL ASSOCIATION. Sedative ; 2. in rheumatism it may be used, and seems undoubtedly indicated as a drug comprising in itself antirheumatic, antipyretic, and analgesic properties; 3. Its low price and feeble toxicity, together with the evi- dence already given, render it a useful addition to our list of remedies. Practically nothing has been written upon it in this Country during the past year, and it may be hoped that a good reason may be furnished to account for this inattention in that we obtain fully as Satisfactory results by administering the ingredients in proper proportions made up into an extemporaneous prescription, or other- Wise dispensed separately. Antipyrin (Analgesin) has considerably decreased in demand during the past year by reason of its own deriv- atives possessing some properties superior to it. But aside from this, its too popular use has continued to show so much abuse of it in the way of producing toxic Symptoms, that physicians and the public both show very properly a tendency to avoid its use. Unfortu- nately, toxic cases have been numerous during the year past, and apparently are somewhat on the increase, or rather the proportion of them may be greater. As it is now some eight years since this then new Syn- thetic compound with such a trivial name was patented and introduced by a German manufacturer, it may be of Some interest to recall its composition. Dr. Knorr was the first to give us some particulars on the subject, and although the question is replete with technicalities, the brief outline attempted here many will be willing to follow. Dr. Knorr found that antipyrin was one of a series of derivatives from a hypothetical base called chimizin. These derivatives are products of the action of di-acetic ether upon one of the hydrazines. If then one molecule of phenyl-hydrazin be taken and acted upon in the cold by one molecule of di-acetic ether, the elements of water are eliminated and the residue COm- bines to form phenyl-hydrazin-di-acetic ether, which MATERIA MEDICA, PHARMACY. THERAPEUTICS. 597 upon heating to 100° C., parts with the elements of ethylic alcohol and is converted into methyl-oxy-chini- zin. This latter possesses the properties both of base and acid, but still contains an atom of hydrogen easily replaceable by an alcohol group, and the compound then loses its acid character and is converted into the base di-methyl-oxy-chinizin or antipyrin. Some writers still have extravagant ideas of its being a cure-all, but they are greatly in the minority. Again, it is still a mooted question whether small or large doses give the best results, but as it does not appear to bear any relation whatever to the ailment treated, but rather to each individual observer's habitual practice, the ques- tion is far from being settled. Several series of cases of pertussis during the year have yielded well to its administration in the hands of such men as Drs. E. Feer and Amos Sawyer, of our own country, but the experience of Dr. W. A. DeWolf Smith, of New Westminster, B. C., is rather against its use." Dr. E. B. Gleason, of Philadelphia, has made quite a good record with it for the past three years “As a Local Application in Inflammation of the Mucous Mem- brane of the Upper Respiratory Tract.” Experiments continue to be repeated and extended to Confirm its destructive action upon the bacillus of diph- theria. Outside of the body the conclusion seems pretty clearly drawn that it does destroy the bacillus in about forty-eight hours. Dr. Charles Leroux adds his favorable results to those already on record from its uses in cases of chorea. He has succeeded in forty-one out of sixty cases. Antipyrin Will finally settle down to a moderate and selective use from which we may look forward to and confidently ex- pect to have very definite and beneficial results. e Antise ptin is an article which was introduced some time ago as a definite chemical compound called iodo- * The Medical News, Vol. 60, p. 48. * N. Y. Med. Jour., Wol. 56, p. 482. 698 JNEW YORK STATE MEDICAL ASSOCIATION. boro-thymolate of zinc, but it has now been pretty clearly demonstrated to be simply a mixture of Zinc Sulphate e º e e e & tº 85 parts, Boric Acid . ſº e e e º e 10 “ Zinc Iodide * * e g º ę * 2} “ Thymol . . . . . . . 2; “ Apparently little interest is manifested in the article. Antiseptol (Cinchonine-Iodo Sulphate) has been only Occasionally heard from the past year, but undoubtedly many practitioners have made good use of it without thinking it worth while to make any definite statement. We have had one personal report from this country— that of Dr. Hugh Hamilton, of Harrisburg, Penn., who has had very gratifying results (as an iodoform substi- tute) for more than sixteen months. It is to be hoped that Dr. Hamilton will publish his results. Apiol, the green oleoresin obtained from the fruit of Our common parsley (Apium Petroselinum), has of late Varied much in its physical properties—particularly in its color, density, and action to various solvents—and rarely have the samples been equivalent to the article as origi- nally proposed by Joret and Homolle many years ago. To this fact may be due some of the disappointing results now noticed when using it in the treatment of amenor- rhoea and dysmenorrhoea. The cause of the variation is not yet explained. Aristol, (Annidalin)—the iodoform substitute—is not so much in demand, principally on account of the increased call for its rivals, dermatol, europhen, sozoiodol and the like. Probably at the present time its largest consump- tion is by the rhinologists in affections about the nose and pharynx. In limited applications the dermatologists still cling to its use. It has the advantage over dermatol in being soluble in oil and ether. In the treatment of chancroids the profession still seems to be somewhat divided as to its efficacy. Dr. T. Edmund Günts now reports from his two years' use that, in the treatment of venereal ulcers it MATERIA MEDICA, PHARMACY. THERAPEUTICS. 599 should not be employed in the form of ointment, or otherwise than dusted directly upon the ulcer, followed by a drop of olive oil, which obviates that thick, brown condition formed when mixed with the oil before appli- cation. As fast as the solution of the aristol occurs, absorption goes On, and effectual results are obtained. The solution in oil of sweet almonds, hypodermically injected in the treatment of pulmonary tuberculosis, gives some satisfaction, no doubt, but sufficient time has not yet elapsed, and the cases are far too few to enable a just conclusion to be drawn at present. It apparently gives its best results in the primary and secondary stages, and the injections cause no pain and no inflammation, eschar or induration. Arsenite of Copper (Scheele's Green) has been in increasing use for the year past in treating diarrhoea, dysentery, cholera infantum and all gastro-intestinal irritations. Very various results are reported — many quite conflicting. In general it may be concluded so far, that the claimed success may be largely attributed on the One hand to the older and well-tried remedies which have been so frequently used in conjunction with it, and on the other to the hygienic and dietetic treatment which is SO rationally found to be the necessary accompaniment. Self-limitation as well, of course, must receive much Credit for many of the so-called cures. Asaprol (6-Naphthol-a-Mono-Sulphonate of Calcium) is probably one of the very newest antiseptics. It is a White scaly powder, readily soluble in water and obtained by the action of heated sulphuric acid on pure g-naph- thol, and then a calcium salt made with the resulting acid. It has been pretty much confined to the locality of its origin–Paris. Its introducers, Drs. Stackler and Dulief, together with Dujardin-Beaumetz, are about the only ones who have experimented with it in much detail, and practically nothing is actually known about it in this °ountry as yet. They advocate its use internally in the treatment of gout and rheumatism of all degrees—partic- 600 NEW YORK STATE MEDICAL ASSOCIATION. ularly acute articular rheumatism; in typhoid fever and influenza. The growth of the bacilli of Asiatic cholera, herpes tonsurans, typhoid fever and anthrax has been retarded, if not wholly arrested by this agent. We probably will hear further from this article later. Aseptol (Ortho-Phenyl-Sulphonic Acid) is the name given by Hueppe to a sulphonic derivative of carbolic acid and obtained by mixing in the cold equivalent parts of carbolic and sulphuric acids. It is a thick, reddish liquid, quite volatile and readily soluble in water. Although its odor is like that of carbolic acid, it is less caustic and more antiseptic, and from its less irritating property it has been given internally in large doses. It has not supplanted carbolic acid so far, however, although it has now had several years to fulfill the original expec- tations. Assafoetida has been recently recommended in cases of habitual abortion. The London, Laºcet' states as fol- lows: “Dr. Turazzo gives it in pills containing a grain and a half as soon as it becomes clear that a new preg- nancy has commenced. At first only two pills are pre- Scribed, but later on the number is gradually increased to ten daily. The treatment is continued until the labor is over, and then the daily dose is gradually diminished. By this method cases, where as many as five successive abortions had occurred, have been successfully treated, and where in one instance a miscarriage appeared to be imminent during the seventh month, it was averted, and the patient was delivered at full term.” Atropine continues to find successful use in cases of lead poisoning. Previous good reports are on record, and now F. Rowland Humphreys, L. R. C. P., of Queens- Crescent, Haverstock Hill, London, adds five to his pre- vious successful result. He uses about 4 milligramme (1+r grain) of sulphate of atropine and 324 milligrammes (5 grains) of iodide of potassium. It appears from his 1 Vol. II. for 1892, p. 320. MATERIA MEDICA, PHARMACY, THERAPEUTICS. 601 experience that atropine in full doses relieves the colic and the pain in the head in the most rapid manner, keeps the bowels open freely, assists in the return of the bodily powers, and aids, directly or indirectly, in the removal of the lead by the iodide of potassium. On the Continent, during the year past, atropine has had an increasing use as a haemostatic. It has been used with good effect hypodermically in from # to 1 milligramme (+++ to ºr grain) doses in profuse metror- rhagia after abortion, or of obscure origin, and in phthi- sical haemoptysis. It may require as many as four injections, but rarely more, to produce a cessation of the flow. It appeared to act well in some of the cases where ergot and plugging had been tried in vain. Only trifling dilatation of the pupils was noticed. Benzanilid (Phenyl-Benzanide) is an antipyretic closely allied chemically and therapeutically to acetan- ilid, and suggested by Dr. Kähn Some five years ago as especially adapted to the treatment of children. Experi- ments were made at that time with a series of anilids, but Only benzanilid, acetanilid, and salicylanilid were found effective, the benzanilid presenting an advantage over acetanilid in the absence of objectionable auxiliary action following its administration. It is produced by boiling together equivalent quanti- ties of benzoic acid and aniline, and occurs as a white Crystalline, odorless powder with a slightly caustic taste, and practically insoluble in water. It is given to chil- dren in initial doses of 100 to 600 milligrammes (14 to 9 grains). It is comparatively little heard of now, but Occasionally some observer has a sufficiently successful Series of cases to warrant making a report. This is the Case With Dr. Luigi Cantu, who gave it in 5 cases of typhoid fever, 12 of rheumatism, 4 of pneumonia, 3 of neuralgia, 3 of Sciatica, 2 of malaria, 1 of chorea and 1 of tetanus—pushing the dose to 1 and 2 grammes (15 and *0 grains) and even in some cases to 4 and 6 grammes (60 and 90 grains). He regards it as a simple antipyretic, 602 NEW YORK STATE MEDICAL ASSOCIATION. and to have little other influence on the course of a dis- €3.Sé. Benzol (Benzene of the English)—obtained by the dis- tillation of coal-tar—has been making a very favorable record for itself for the past year in the treatment of pertussis and of influenza, and two interesting papers' occurring together, giving the results in the treatment of influenza by benzol and carbolic acid, are of note in this connection. They are both by English observers who have treated many cases. One of them, Dr. William Robertson, of Newcastle-on-Tyne Throat and Eye Hos- pital, while speaking especially of his very favorable results in influenza, mentions incidentally that he has employed benzol in the treatment of pertussis “with unvarying success for years,” and observers from all Quarters pronounce it a reliable pulmonary antiseptic. It has been found effectual in destroying pediculi capitãs or pubis, and, if fire be carefully avoided, is most convenient and cleanly. A single application is, as a rule, sufficient. From Germany we hear that Dr. Putter, Jr., has met with success in treating simultaneously twenty-seven cases of supposed trichinosis with benzene (benzol), fol- lowing it with a brisk laxative. His deductions are not altogether convincing, however, for he is not positive that the portion of the pork eaten by each was impreg- nated, although that tested afterwards proved to be full of trichinae, and supposing the patients did swallow Some of the trichinae it does not follow that they necessarily lodged in the alimentary tract. Nevertheless, Dr. Putter is so convinced that his treatment was effectual, that he Strongly recommends it in all such cases. Benzonaphthol (6-Napthol Benzoate) is one of the new antiseptics introduced by MM. Yvon and Berlioz, of Paris, as a substitute for Betol, as the salicylic acid pres- ent when the latter compound splits up in the intes- tines, affected the kidneys harmfully. To avoid the use * Brit. Med. Journal, Vol. 1 for 1892, p. 171. MATERIA MEDICA, PHARMACY. THERAPEUTICS. 603 of salicylic acid entirely, benzoic acid was chosen to combine with the ſº-naphthol to form this new com- pound. It occurs in small, dull, white, odorless and tasteless crystals, practically insoluble in water at ordinary temperatures. Dr. Gilbert’s trials with it in the Paris hospitals showed it to have very decided diuretic power in addi- tion to its antiseptic properties in the intestines. Mr. Dominici carried on a series of experiments, under Dr. Gilbert, on guinea-pigs, thereby establishing the follow- ing conclusions, which need further experience to sub- stantiate them: - It is very slightly toxic ; Its antiseptic power is comparable with that of the other substances employed in promoting intestinal anti- Sepsis ; It promotes diuresis and diminishes the toxicity of the urine ; The portion of it which is absorbed is easily and rapidly eliminated by the kidneys; A dose of about 250 to 500 milligrammes (4 to 8 grains) Suspended in syrup and water suffices in the majority of CàSéS. Benzosol (Benzoyl Guaiacol) occurs in small color- less, odorless, and almost tasteless (slightly aromatic) Crystals, practically insoluble in water. The increasing use of guaiacol in the treatment of pul- monary tuberculosis has caused further attention to be 8TVen to the preparation of the wood-tar products obtained by fractional distillation, and a short time ago this benzosol was brought forward as a powerful anti- septic and antipyretic. It is prepared either by convert- *8 guaiacol into a potassium compound, purifying and heating With a definite quantity of benzoyl chloride, or *8ain by heating guaiacol with benzoic anhydride (ben- zoic acid). In administration, the gastric juice splits up this com- Pºnd into its constituents, and liberates the effective 604 JNE W YORK STATE MEDICAL ASSOOIATION. guaiacol under conditions that avoid the unpleasant taste of the latter, and that reduce the local irritation which otherwise results. It has been used repeatedly in in- cipient pulmonary tuberculosis, but owing to the pleth- ora of remedies recommended for this affection during the last year or two, it has not received the prominence it may now assume. It has also been used successfully wherever creasote is applicable. Bromamide, the new antipyretic bromine compound of the anilid group, containing 75 per cent. of bromine, has received some careful attention from Dr. Augustus Caillé, of New York City, who carried on a series of experiments with it in the German Hospital for five con- secutive months. It is a very stable compound, occurring in neutral, colorless, nearly odorless, tasteless, needle-like crystals, insoluble in water. Dr. Caillé administered it in doses of 650 milligrammes to 1 gramme (10 to 15.5 grains), to healthy adults, pro- ducing a slowing of the pulse without Sweating, and in doses of 65 to 200 milligrammes (1 to 3 grains), to chil- dren from one to three years of age without untoward symptoms, in cases of “typhoid fever, acute articular rheumatism, chronic rheumatic arthritis, chronic nephri- tis, acute fibrinous pneumonia, rheumatic fever with acute endocarditis, general and localised dropsy due to hepatic, renal, or cardiac disease, and diverse forms of neuralgia; and special attention was given to a possible antipyretic, diuretic, diaphoretic, anti-neuralgic, and sedative action of the drug.” He now makes his Pre- liminary Report,” giving a compact detail of his nine cases. It appears to have “the power of reducing the temperature in most cases of febrile disease from 1" to 2.5° F., without the excessive sweating as produced with other antipyretic drugs.” He very rightly feels encour- aged from his trials, and thinks they “warrant further experiments, especially in other forms of disease.” 1 N. Y. Med. Journal, Vol. 55, p. 208. MATERIA MEDICA, PHARMACY. THERAPEUTICS. 605 Bromides, and particularly the most largely used potassium bromide, still have their drawbacks in use. Bromism, and the ill-effect of the alkaline base, are often too soon established, and administration has to be dis- continued. Expedients have repeatedly been tried to avoid these disadvantages, and it is now recommended from France to use the strontium salt as an alternate. M. Germain Sée records some successful results with strontium bromide in the treatment of thirty-two cases of gastric catarrh. In all, obvious improvement was noted. In epilepsy, also, this salt gave good results. M. Féré confirms the above, and especially in epilepsy, where he used both the strontium and calcium salts. Again, with all the bromides, the effect is by no means universally beneficial, and some observers place the cause to neglect of early attention. Better results are obtained by Poulet if the bromide be combined with either cala- bar bean, belladonna or digitalis. The treatment must be continued for several months to a year. M. Féré maintains that after repeated large doses of the bromides the alimentary tract is in a condition of Sepsis, which prevents the assimilation of the salt, and therefore he would recommend the use of some intestinal antiseptics, as ſº-naphthol and sodium salicylate, com- bined with the bromide to thus remove the intolerance so frequently noticed. His prescription is: Potassium Bromide, & g . 6 grammes (90 grains.) /3-Naphthol, . * * gº . 4 “ (60 “ ) Sodium Salicylate, . . . 2 “ (30 “ ) ſº Mix and divide into three doses, giving one dose three times daily. Féré claims this not only to be preventive but curative treatment. Bromoform is now well prepared by the action of sodium hypobromite on acetone (made by the dry distil- lation of acetate of lime). Caution must again be em- Phasised in the selection of this article, as it should * * clear, colorless liquid, with an agreeable odor and SWeetish taste. If the liquid has color it should be 606 NEW YORK STATE MEDICAL ASSOCIATION. rejected, as it denotes decomposition, and therefore is treacherous. - It still has an increasing use in the treatment of per- tussis, with comparatively few failures. It apparently simply aborts the paroxysms, and probably reduces their number somewhat, but has little other effect on the regular course and duration of the affection. Increasing doses must not be pushed too far, especially in children, as toxic symptoms have manifested themselves in more than one case. The late Prof. P. W. Bedford, of New York City, recommended the use of glycerin as a perfect Solvent, which water is not, and suggested the following prescription, which has been a serviceable one : Bromoform, º -> º © 1.0 cc. (16 minims.) Alcohol, . o º º - 7.5 cc. ( 2 fluidrachms.) Glycerin, . º e & . 45.0 cc. (12 & 4 ) Tinct. Cardamon. Comp., . º 7.5 cc. ( 2 ( & ) Inhalations of bromoform have been used with Some success both here and in England in the treatment of diphtheria—particularly in recent epidemics. The topical application recommended some two years ago by Dr. S. Solis-Cohen, of Philadelphia, continues to meet with some favor in cases of ozaena, and tuberculous and other ulcers of the larynx. It acts as a deodoriser, disinfectant and analgesic. Calcium Chloride added to a fibrin-ferment Solu- tion forms a combination which is suggested as a new styptic. It has been tried successfully upon animals by Dr. A. E. Wright, of Dublin, to possibly increase the coagulability of the blood in the vessels in cases of haematophilia, aneurism and internal haemorrhage. He has not pushed his trials in man and unfortunately does not intimate that he intends to do so, but the whole sub: ject is interestingly treated, and deserves more extended attention." Camphoid is the name suggested by Mr. William Martindale, of 10 New Cavendish street, London, W., 1 Brit. Med. Journal, Vol. II. for 1891, p. 1806. MATERIA MEDICA, PEIARMACY, THERAPEUTICS. 607 England, for a new substitute for Collodion, recently recommended by him, consisting of One part of pyroxy- lin (soluble gun cotton), 20 parts of camphor and 20 parts of dilute alcohol. He publishes the following note: 1. “It is known that iodoform is soluble (1 in 10) in Rubini’s solution of camphor, composed of equal parts by weight of camphor and dilute alcohol. This requires fixing on the part to which it is applied. I therefore added 1 part of pyroxylin to 40 of the Solution, and found it dissolved readily. Applied to the skin this preparation dries in a few minutes and forms an elastic opaque film, which does not wash off. The excess of camphor seems to volatilise, and as it disguises the odor of the iodoform its solution forms a useful vehicle for applying this drug. Pyroxylin dissolves readily in the simple solution of camphor, and this forms a cleanly basis for the application of many medicaments to the skin, such as carbolic acid, salicylic acid, resorcin, iodine, Chrysarobin and ichthyol. . . . . .” Cantharidin treatment of tuberculosis has appar- ently not met with much substantial success on the Whole during the past year. The conservative opinion of foreign practitioners may be pretty fairly summed up in the conclusions arrived at by F. Coccia in his careful trial of Liebreich's treatment by the use of potassium Cantharidinate : 1. The injections are very painful, and the method is therefore difficult of application in the case of patients Who have to continue at their work ; * Doses of ſº, of a milligramme (ºr of a grain) are not dangerous in any class of cases ; 8. Doses of + of a milligramme ( s#W of a grain) are ºfficiently dangerous to be contra-indicated in cases of *Vanced pulmonary tuberculosis; * The injections, when frequently repeated during a long period of time, cause physical prostration and *ious mental depression; 1 The Pharm. J Ourn, and Trans., 3d series, Vol. XXII, for 1891–92, p. 831. 608 NEW YORK STATE MEDICAL ASSOCIATION. 5. In the last stage of the disease the treatment is absolutely inadmissible ; 6. In incipient cases the injections may be used with the view of modifying the bronchial mucous membrane and the expectoration, and relieving cough ; 7. The night sweating and the general condition may be favorably influenced by the treatment in the early Stage ; 8. The injections have no effect on the fever, and hae- moptysis seems to be made more frequent by them ; 9. Neither the pulmonary lesions nor the bacilli are in any way modified by the treatment, and 10. Tuberculous ulcers in the larynx are not affected, except that in the very early stage they show a slight tendency to become cleaner. Prof. Liebreich attempts to answer his critics and to learn from their criticisms, and thus pushes on his investigations with characteristic persistency, evidently intending to leave no stone unturned to accomplish his life object. We trust, for the welfare of humanity, that his pertinacity may eventually succeed. He is now trying the sodium salt, with which he obtains satisfac- tion so far, especially in cases of lupus. Castoria, which has been so profusely advertised on almost every available square inch of house and fence surface unprotected by the warning “Post no Bills. under Penalty of the Law,” has been counterfeited () by some obtrusive intermeddler with lucrative Com- mercial interests, by producing like results with a mixture of Fl. Ext. Alexandria Senna, Fl. Ext. Levant Wormseed, Fl. Ext. Peppermint, Fl. Ext. Anise Seed, Wintergreen Oil, Rochelle Salt, Sodium Bicarbonate, White Sugar, Molasses, Alcohol and Water—the alcohol being very nearly one-third, the Senna about One- sixth, the molasses about one-twelfth each by mºº ure, and the “sugar two ounces by weight.” " originator of Castoria may claim that this concoction is not at all the true article, but nevertheless “ children MATERIA MEDICA, PHARMACY. THERAPEUTICS. 609 cry for it” as loudly as for his, and what more can one ask Chloralamid (Chloral Formamide) continues to be used in about the same line of affections as a year ago, but its employment has become more general. Its purely hypnotic effects are still pronounced and well recognised in the same class of cases as before noted. Its more extended use shows that it has a much larger range of usefulness than its rivals chloral, paraldehyde or Sul- phonal. Its marked characteristics, which are being recognised and taken advantage of every day, first of not requiring an increased dose after continued use, and second of definitely establishing the habit of sleeping by its systematic use so that the habit is well kept up after administration has been discontinued, are inestimable qualifications. During the past year it has been found especially valuable in cardiac asthma, and renewed claims for its Superiority in sea-sickness have been prominent, although not by any means conclusive. It is true that there have been some disappointing results reported this year, as well as last, but they are Comparatively few, and we may very safely say in general, that in chloralamid we continue to have a safe and reasonably reliable hypnotic. Chlormethyl (Mono-Chlor-Methane) is a remedy to be used in the treatment of neuralgias of all kinds, and it is rather surprising we have heard so little of it during the past year—at least from the Continent—after such a favorable report made by Steiner a short time ago. It is Put up in copper siphon bottles in a fluid condition Produced by pressure, and in using it a jet of the fluid is P*mitted to strike the painful region. It not only pro- duces a local decrease of temperature of the part, but it relieves the pain by diminishing the excitability of the *Sory nerves. Steiner used it successfully in extreme * of ischiatic neuralgia, and strongly advocated its ºnore general trial. 39 610 MEW YORK STATE MEDICAL ASSOCIATION. Chloroform in particular, and anaesthetics in gen- eral, are still paramount questions under discussion in the old country, generally, but especially in England, as the Germans have “trod on their toes” a little by pre- senting to the professions of medicine and pharmacy a brand of chloroform which is claimed to be so much purer than any other known, that it is the only article to be used in order to avoid the unfortunate results which have followed the administration of chloroform of late. This is hard for the Englishman to bear, and immediately the two professions there are put on the defensive to explain away the shortcomings, either of their article or of their mode of administration. Dr. Raoul Pictet, a Swiss chemist, formerly of Geneva, but now of Berlin, Secured a patent in Germany, and sent out from his firm of Raoul Pictet & Co. samples of chemically pure chloro- form obtained by refrigeration in his special apparatus, constructed to produce a temperature from — 20° C. down to —200° C., and applicable not only for chloroform, but for all purposes requiring these low temperatures. The specification of this patent is as follows": “It states that the purification is effected in a copper cylinder, Sur- rounded by a jacket hermetically sealed at top and bot- tom and provided with an inlet and outlet pipe. The process is carried out in three stages. First, the chloro- form in the cylinder is cooled down to 80°C. by allow- ing ethyl chloride, ethylene, protoxide of nitrogen, or “Pictet's liquid,’ to evaporate in the jacketed Space Out- side the cylinder, and filtering the cold liquid mass. Foreign bodies crystallising above this temperature are thus removed, and the chloroform is filtered off. The second stage is to solidify the chloroform thus obtained by reducing the temperature of the cylinder to -89° 0. when about two-thirds of it freezes against the sides of the reservoir. The remaining liquid is drained off, and the solid chloroform melted and then run out of.” cylinder for the second time. The product thus obtained *The Chemist and Druggist (London), Vol. 40 for 1892, p. 40% MATERIA MEDICA, PHARMACY. THERAPEUTICS. 611 is finally subjected to distillation at a very low tempera- ture under reduced pressure, the cylinder used in the previous stages of the purification now serving as the receiver. The first and last portions of the distillate are rejected, whilst the intermediate product, amounting to about 80 per cent. of the total, is obtained as ‘chemically pure chloroform.’” Dr. Pictet and nearly all his followers have claimed from the first that his chloroform would not decompose on exposure to light, and that a practically unchangeable liquid is produced by the patented process. Unfortun- ately for his cause, however, one of his own experiment- ers apparently inadvertently explained that it would decompose if the alcohol which was added to preserve it be removed. This was afterwards fully verified by actually producing decomposition in about ten days when freed from the one per cent. of alcohol it contains ; and furthermore additional investigations in Berlin proved that there was no sensible difference between his and any other well purified brand. At a certain spasmodic stage of the discussion great Stress was laid upon the impurities which could be Separated from all brands, and for a time it was thought that a solution of the difficulty found with the anaes- thetic was discovered in this defect; but it has since been clearly shown that this very small quantity of residue Would not only have no effect therapeutically, but any possible effect from such a cause would not produce the pronounced symptoms complained of. Throughout this whole agitation, a marked example is furnished of the perfect indifference foreigners, and par- ticularly the English, show to anything accomplished in the United States. They apparently pay little attention to any Scientific work which has been done here. This * Very noticeable in some of the investigations which have been attempted on this subject in question, for * of that very work has been on record here for forty * back, and it is amusing to notice how many times 612 NEW YORK STATE MEDICAL ASSOCIATION. they announce some wonderful (?) observations which have been known and published here for years. If they showed the true scientific spirit they would acknowl- edge and make use of all available work accomplished from whatever source, beginning their investigations where others left off, and thus gain the glory, if they need such, by improving on and perfecting what had gone before ; but they are apparently so indifferent to this spirit that they go to work at questions which have long ago been taken up, settled and published, in order to Originate for themselves, even though it be old matter. It would seem that definite conclusions as to the relative mortality of chloroform and ether could not be justly drawn at this time any better than last year, as a large proportion of fatalities have occurred either from the use of the particular anaesthetic employed on individuals in whom it was plainly contra-indicated, or from carelessness in administration, and not from impurities in either anaesthetic. This statement is not intended, by any means, to underrate the impor- tance of purity in the anaesthetics, but simply as a protest against hypercritically laying so much stress on the small amount of impurity found. In the direc- tion of impurities, decomposition evolving a chlorine vapor, in the case of chloroform, is the one thing to be recognised in advance, and avoided. This can readily be done by the administrator just before using. It is very unfortunate, as was alluded to here a year ago, under the head of “Ether versus Chloroform,” that not only individual practitioners, but sections of country are so unalterably wedded to their particular anaesthetic that they insist on using it exclusively. Surely some cases are, after even only a rough examination, found suitable for chloroform and others for ether, so that routine practice has its disadvantages. The discussion on anaesthetics at the last annual meeting of the British Medical Association, held in Bournemouth, took a turn decidedly against many of the strongly MATERIA MEDICA, PEIARMACY. THERAPEUTICS. 613 emphasised statements of the Hyderabad Commission, and led to the appointment of a representative Com- mittee to report on the whole subject from a clinical standpoint. * Also the Nyzam of Hyderabad, India, has thought the subject of enough importance to appoint a third Commis- sion to reconcile, if possible, the conflicting views now prevalent, and Dr. H. A. Hare, of Philadelphia, has been asked to undertake the task here. Dr. Hare now desires to receive reports from American practitioners “of any cases in which it was noticed that the heart stopped beating before respiration, or respiration stopped before the heart.” Convallaria Majalis (Lily of the Valley) has by this time reached the stage at which all newly pushed reme- dies arrive if they can stand the strain of over-pushing. Although a remedy long used in Russia for dropsical affections, still its usefulness was not sufficiently empha- sised until it was noted that it might take the place of digitalis. This it still cannot do, but it does offer a very efficient alternate for digitalis in many cases. It is to be hoped that the Revision Committee will recognise it in the forthcoming issue of the U. S. Pharmacopoeia. Creasote obtained for medicinal use only from beech- wood tar, still holds its own in professional popularity in the treatment of pulmonary tuberculosis — largely used, added to or in conjunction with cod-liver oil. Larger doses are now urged than used to be given. In Southern Germany they appear to be very bold and even approach recklessness in the heroic doses employed. Dr. Francis P. Kinnicutt, of New York City, in his Middleton-Goldsmith Lecture for 1892 on “New Out- looks in the Prophylaxis and Treatment of Tuberculosis,” gives the most complete consideration of this subject Which has been reported for some time back. One of his most interesting series of records are those cases treated by creasote and guaiacol. He concludes that large doses * N. Y. Med. Record, Vol. 41, p. 561. 614 NEW YORK STATE MEDICAL ASSOCIATION. apparently possessed no advantages over much smaller ones, and had no greater effect upon hectic and night sweats; that subcutaneous injections of the drug pos- sessed no advantages over administration by the mouth ; that whatever beneficial influence it might exert in pul- monary tuberculosis could be effected with a compara- tively small dosage, and that favorable results could be expected only by its continuance and prolonged employ- ment. In Germany, Dr. Julius Sommerbrodt states that the earlier it is used the better are the results. He therefore has used it in so-called scrofulous children with very good effect. He recommends it in larger doses than usual, as he finds smaller ones are useless, and he continues it for several months. It will thus be noticed that observers differ in some of their conclusions. In France, pertussis and laryngitis accompanying La Grippe have both been treated by creasote with success. Creolin—the coal-tar product — has not gained much in popularity during the past year. A series of compari- sons of the disinfecting values of lysol, creolin and carbolic acid has been carried on, and their value is rep- resented in the order here named. Creolin might have assumed a more prominent place if some quite unfavor- able results had not been reported from its use. Cresol lodide (Ortho-Cresol Iodide) is another of the numerous substitutes for iodoform. Cresol is the promi- nent constituent of crude carbolic acid in varying propor- tions of the ortho-meta and para-cresols. The iodide of the Ortho-cresol is the one found to be efficient as a disin- fectant, especially in nasal and laryngeal affections. It is a fine, pale-yellow powder with a pronounced Odor, but agreeable in comparison with iodoform ; it is insolu- ble in water. All the compounds of cresol are powerful antiseptics, but all have the disadvantage of a very variable composition, of adhering to or rendering slip- pery the operating instruments and hands, and of readily oxidising in the air. These disadvantages apply to all the MATERIA MEDICA, PHARMACY. THERAPEUTICS. 615 various compounds of cresol known as lysol, solveol, Solutol, saprol, etc. This iodide has not been long enough in use to predict its future, but, surely, almost anything is at once seized upon which attempts to supply a satisfactory substitute for iodoform. Dermatol (Bismuth Subgallate)—last year's new sub- stitute (or rather of two years ago) for iodoform—although it has by no means supplanted the latter agent, still has held its own pretty well and finds good use in suitable cases. Considerable attention has been given during the year to comparative observations with this agent and its rivals. Colasanti has made comparative bacteriological experiments on wet and dried cultures with aristol, der- matol, and iodoform as to their microbicide potency. Neither agent apparently had any effect on the microbes in the dried cultures after three days contact, but in the wet ones, dermatol was effective in little more than half the time of the others. One of the most complete investigations upon this agent of late, is that of Dr. Arthur K. Stone, of Boston, communicated in a paper' read at the last annual meeting of the Mass. Med. Society, on “Bacteriological and Clinical Investigations into the New Antiseptic, Der- matol,” which is surely worth reading by those interested in this subject. Doernberger has made good use of a 10 per cent. vaseline ointment of dermatol in the Children’s Hospital at Graz, particularly in moist eczema and burns. In otorrhoea, he still withholds his opinion, but in phlyctenular conjunc- tivitis he finds it useless. Several others quite confirm these results, but Davidsohn gets good results in quite a Series of cases of otorrhoea. The antiseptic property of dermatol is at this time Somewhat in dispute, but its extraordinary desiccating effect is still pronounced and remarked favorably upon by all. * Boston Med, and Surg. Journal, Vol. 127, p. 207. 616 NEW YORK STATE MEDICAL ASSOCIATION. On the whole, then, last year's promises have been quite well fulfilled—except that it has not supplanted iodoform. Diaphtherin (Oxy-Chin-Aseptol) is one of the very newest antiseptics—another of the interminable coal- tar derivatives. Its shorter fancy name comes from Öiaºpffeipo, to destroy, and it is prepared by a process not yet made public, but its composition consists of two molecules of oxychinolin and one of aseptol. It is reported as a yellow powder, with an odor somewhat like carbolic acid, and readily soluble in water and in most of the ordinary solvents. It is little heard of as yet outside of Germany, and although Dr. Kronacher, of Munich, now states that he has been using it successfully for a year in his surgical practice, chiefly in a 1 per cent. Solution, but often in as strong a solution as 50 per cent., still it was not presented to the profession at large until the recent Eleventh Con- gress for Internal Medicine, held in Leipzig, where Prof. R. Emmerich, of Munich, presented a sample and explained its alleged superiority over carbolic acid, corro- sive sublimate, lysol and the like — showing less toxic properties than all, and being a less costly agent than carbolic acid. From its composition it should theo- retically be the most potent antiseptic. It, however, apparently cannot be used to disinfect operating instru- ments, as it attacks even silver and nickel plating (nickel less than others, especially when newly plated)—a dark blackish deposit being formed, which, although not poisonous in its action, still is quite an objectionable feature. Apparently, the 1 per cent. Solution in water, recommended by Dr. Kronacher, is fully strong enough for surgical dressings. It is stated that it is non-caustic, and does not produce eczema. It does stain the hands and nails of a light yellow color, but this is not indelible, and may be easily removed by washing. It is said to have marked bactericidal properties, and its special applica- tions are to burns, ulcers and operating wounds, even of large extent. MATERIA MEDICA, PHARMACY. THERAPEUTICS. 617 From reports at hand, then, it may be stated that it possesses marked antiseptic properties and very few disadvantages. Diuretin (Sodio-Theobromine Salicylate) has increased somewhat in demand since last year, but some of the statements in its favor have to be modified considerably in the light of a year’s experience with an increasing number of observers. Dr. R. Demme, of Berne, Switzer- land, has been the most prominent extensive foreign clinical reporter of its use during the year. He used it in the Berne Children’s Hospital with marked success. In cases of dropsy, where calomel and hot baths were apparently unsuitable, and where the usual diuretics were of little benefit, he met with success. He believes its effects are due to its action upon the renal epithelium. In the severe dropsical stage of scarlatinal nephritis and of mitral disease, it has been of much service, even after digitalis had had no effect. Although he and many others have noted its non-cumulative effect, still he had One case of amyloid degeneration of the liver, kidneys and spleen, in which it caused an erythematous rash, together with a profuse diarrhoea. He does not give much encouragement in using it in children less than one year old. As a dose for children from two to five years of age, he recommends from 500 milligrammes (about 8 grains) up to 1.5 grammes (about 25 grains) in divided doses daily; from 6 to 10 years of age, up to 3 grammes (about 45 grains). The administra- tion was continued in many cases for weeks without either cumulative or diminished therapeutical effect being evident in any way, and the benefit in some of his cases was very striking. In our own country, on the other hand, Dr. H. A. Hare, of Philadelphia, has not met with many favorable results in administering it to adults as a diuretic. He even pushed the dose in one case, that of an elderly man with enlarged Drostate and very concentrated urine, to 7.8 grammes (120 grains) daily, with the result of decreasing the flow of urine instead of increasing it. 618 NEW YORK STATE MEDICAL ASSOCIATION. Dr. E. L. Keyes, of New York City, feels now called upon to retract some of the claims he had conscientiously but modestly believed might be held concerning this agent in “averting urinary or urethral fever,” and as he promised, when he made his previous report, to continue his observations, he feels in justice called upon now to report his failures." He is still studying the matter, and may have something further to say after another year's experience with this and other diuretics. It may be well to again allude to the very unstable condition of this compound, and to caution practitioners not to prescribe it with other things, on principle. It is far better to give it by itself either in the powder form or in solution. In either form it is necessary to keep it well sealed from contact with the air on account of its rapid decomposition. - It may still be considered, then, on trial, for it surely has given a good as well as poor record of itself in many cases, and now that the price has been somewhat reduced, its use may be stimulated thereby. Attention is again called to the great discrepancy in price between the article when bought under its shorter name of diure- tin and under its chemical title of sodio-theobromide- salicylate—the latter, when you insist on having it, cost- ing less than half the former. Moral: always purchase under the latter name. Epidermin is the name given by S. Kohn to a Ger- man preparation (evidently a mixture) to be used as an effectual surgical dressing and artificial skin for wounds and scratches. It is a smooth, milky-white mixture, producing, after spontaneous evaporation, a thin flex- ible pellicle. The exact composition of the compound, as introduced, is not known, but an efficient substitute may be prepared by triturating in a warmed iron mortar 15 parts of melted white wax, with 15 parts of powdered acacia, until a thorough trituration is accomplished ; 15 parts of distilled water and 15 parts of glycerin are * The Medical News, Vol. 61, p. 352. MATERIA MEDICA, PHARMACY. THERAPEUTICS. 619 then mixed and brought to boiling. This is added at Once to the contents of the mortar and the whole stirred constantly until cold. If it is desired to add any medi- cinal property to the pellicle, the medicament should be mixed with glycerin first. Ethyl Chioride (Monochlor-Ethane) has apparently steadily but slowly increased in use ever since M. Mou- net, of Lyons, France, introduced it, put up in the form of small glass tubes, in which it occurs as a colorless liquid with a burning but sweetish taste. It is obtained by passing chlorine gas through an alcoholic solution of zinc chloride to saturation while surrounded by ice, to keep its temperature well down. It is ordinarily gaseous in form, but is easily condensed and introduced into these small drawn-out tubes, and hermetically sealed. The tube is to be broken off at a spot in the narrow extremity marked by a scratch, so that by the warmth of the hand holding it, a small jet of the vaporised liquid is projected on the part to be anaesthetised. It is very inflammable, and therefore must not be used in the vicinity of fire. The above mode of using it is found to be by far the best on account of being always available, and no preparation has to be made up to the moment of using. It has thus gained much favor in France and Switzerland with dentists, and for minor surgical opera- tions, but has not spread much further. Eugenol-Acetamide is a new anaesthetic, patented in Germany, analogous in action to cocaine. The foun- dation element is eugénol (eugénic acid) obtained as an oxidation product from oil of bay, oil of cloves or oil of pimento, but chiefly commercially from oil of cloves. The process of purification of eugénol has been much improved of late, and we therefore should get better results from the antiseptic and anaesthetic effects of not Only eugénol itself, which has been in use for several years past, but also more effectual results from the acetamide compound. The latter is prepared by treat- ing the sodium salt of eugénol with monochloracetic 620 NEW YORK STATE MEDICAL ASSOCIATION. acid to produce eugénol-acetic acid. When alcohol and chlorine gas are added, eugénol-acetic ethyl-ether is formed, which, treated with a strong solution of ammonia, gives eugénol-acetamide. This resulting crys- talline product is rubbed up into a fine powder as being the most effective form for practical use. This is so new an article that few reports have yet been made upon it, but it no doubt will be sought for by those who have used eugénol with success—the dentists and surgeons for minor operations. Euphorin (Phenyl-Urethane)—the antipyretic—has found a very satisfactory field for usefulness since last year in obstetrical and gynaecological cases, and many foreign observers give favorable reports. Dr. L. M. Bossi, who has probably used it more largely in this line than any other, is led to think, after a somewhat extended experience, that it acts both more efficaciously and more rapidly than any other substance hitherto in use, not excepting iodoform. Finally, in general, Dr. C. Curtis summarises his experience after its use in some two hundred clinical experiments and bacteriological researches made in the Pharmacological Institute of the University of Rome: 1. It is a powerful and safe antipyretic. It acts better when the fever is at its maximum and during the period of subsidence, than in the early stage, showing itself in from half an hour to two hours; its effect may last even ten hours. 2. Defervescence is attended with a feeling of warmth and moderate sweating, but when the temperature rises again the accompanying rigor is not severe. 3. It does not cause any serious secondary effects. Sometimes there is a little cyanosis, but never collapse. 4. It can be used in preference to any other antipyretic when a rapid and marked lowering of the temperature is required. 5. It answers fairly well in surgical fevers. 6. It is a most potent antirheumatic. In acute rheu- MATERIA MEDICA, PHARMACY. THERAPEUTICS. 621 matism it is certain ; in chronic rheumatism it is also satisfactory — usually succeeding in cases which have resisted all other remedies. 7. In simple fever the dose is 1.2 grammes taken in from four to five doses. In febrile rheumatic affections from 1 to 2 grammes should be given in twenty-four hours. In chronic rheumatism, 1 gramme in three or four doses. On the average, 1 gramme corresponds to 2 grammes of antipyrin. 8. It has a sure analgesic action in neuralgia, unless when due to a specific cause. 9. It is a powerful antiseptic, being intermediate between carbolic acid and corrosive sublimate. 10. It is one of the most effective disinfectants in thrush. 11. In local applications, it has advantages over iodo- form, iodol, aristol, etc. It is more powerfully antiseptic and less desiccating than dermatol. 12. Used locally in powder or in an ointment with vaseline or lanolin, it is also an anodyne, promoting the healing of wounds and ulcers. It gives excellent results in surgery, gynaecology, diseases of the skin, and syphilis. Europhen (Iso-Butyl-Ortho-Cresol Iodide)—one of the most effective substitutes for iodoform—still gives daily evidence of the very unwise practice of choosing very similar names for very dissimilar agents, as it has been repeatedly shown that more good luck than good management has avoided poisoning results from the confusion in name between this article and Eu- phorin. It is not very difficult to see how readily one might be written for the other in a hurriedly composed prescription. Europhen has had a largely increasing use during the past year in throat and nose affections, in spreading ulcers and in soft sores, with such gratifying results that many claim that it excels iodoform. Reports now come from Cuba that Dr. Juan Santos 622 NEW YORK STATE MEDICAL ASSOCIATION. Fernandez, of the Havana Eye and Ear Clinic, has met with beneficial effects from the use of a 9% to 1 per cent. vaseline ointment in many eye affections. Only one ap- plication to the conjunctiva often proved efficacious in cases where other agents failed. He does not extol euro- phen above its rivals, but finds it sufficiently useful to be of marked service in many cases. Its advantages—a far less disagreeable odor, and free- dom from toxic effects—give it a good claim to rank well with iodoform, and repeatedly call forth expressions of approval from all. Exalgin (Methyl-Acetanilid)—the analgesic—unfor- tunately has had too many cases of poisoning attributed to it since this time last year to much encourage many in a more extended use of it. Several of these cases, how- ever, were due either to popular use (abuse) of it, or it was taken without medical direction. In chorea, it appears to have made a favorable record this year. Dr. Hugo Löwenthal, of Berlin, treated thirty- five cases in all stages of severity. It was particularly applicable when there was considerable mental excite- ment. He found that it was of benefit in the majority of cases, but he cannot attribute a specific action to it. In our own country, Dr. C. L. Dana, however, considers it does possess a specific action in ordinary chorea. He treated sixteen cases with an initial dose of 130 milli- grammes (2 grains), three times a day, and increased if necessary up to about 200 milligrammes (3 grains), five times a day, prescribing also the citrate of iron and qui- nine after meals. Acute anaemia and cyanosis were the only unpleasant symptoms he saw following its use. The average duration of the chorea was five weeks. Dr. John Gordon, of Aberdeen, Scotland, gives a very concise account of some sixty-six clinical cases under his observation.” “In fifty-five cases the action of exalgin was successful in relieving the pain, while eleven cases yielded results that were unsuccessful or doubtful. The * The London Lancet, Vol. 1, for 1892, p. 1173. MATERIA MEDICA, PHARMACY. THERAPEUTICS. 623 benefit of exalgin was most marked in cases of nervous headache, facial neuralgia, intercostal neuralgia, and lumbago. Although the pain-subduing action of the drug may be feeble, it has given in certain cases excel- lent results. Further observations will at last fix its full value as an analgesic, and possibly justify the hope that it may take a valuable, if restricted, place in the group of those bodies which relieve suffering.” Finally, Dr. T. Churton, of Leeds, England, has met with some success in the treatment of exophthalmic goitre, and discusses the poisonous dose in connection with his cases." Exodyne is another one of those compounds put forth by an enterprising stock company to catch the attention of the lovers of novelty, and to win over a share of the harvest accruing to like enterprises. It is urged as an antipyretic in 650 milligramme (10 grain) doses. Dr. Goldmann found it to be another of the now numerous acetanilid mixtures : Acetanilid, . e e © * * & . 90 per cent. Sodium Bicarbonate, . [. * g e . 5 per cent. Sodium Salicylate, . e & e e . 5 per cent. Fuchsine (Rosaniline) is the well-known aniline product occurring in bright iridescent crystals, giving a deep-red solution in water, used in the arts as a dye, and in medical science for staining purposes in histological and bacteriological work. In the process of manufacture in commercial quantities, arsenic is retained in variable amount, which, of course, is objectionable for both internal and external use. When used in medicine, then, arsenic should be carefully eliminated. It has been used internally for albuminuria, and externally in a one per cent. alcoholic solution in five Cases of traumatic erysipelas with successful results in all, after only two applications; but the best results * The London Lancet, Vol. 1, for 1892, p. 1175. 624 NEW YORK STATE MEDICAL ASSOCIATION. reported during the past year have been in throat affec- tions. After a constant use since 1888, Dr. Karl G. Bog- roff, of Odessa, reported over a year ago (and his con- clusions may be repeated here), that— 1. Like all other aniline dyes, it is easily absorbed by the laryngeal and faucial mucous membrane ; 2. Antiseptic fluids, when mixed with it, penetrate into the tissues far more deeply and act much more effectively than when employed alone; 3. When injected into the larynx “the superficial cel- lular elements and intercellular spaces become infiltrated with particles of the aniline dye, and thus a thin protect- ive film is formed, which is impermeable not only by any irritating fluids, but even by gaseous bodies”; 4. In cases of reactive laryngeal inflammation in pul- monary tuberculosis from continual irritation by the dis- charges, the intra-laryngeal injection of a two per cent. watery solution of boric acid saturated with fuchsine, rapidly removes the inflammatory phenomena and relieves the difficulty in swallowing ; 5. It proves similarly beneficial in cases of “faucial mycosis.” Callacetophenon (Tri-Oxy-Aceto-Phenon) is a re- cent and promising substitute for pyrogallol (pyrogallic acid) in most skin affections, and principally in psoriasis. For some time back pyrogallol has attracted some attention in the treatment of psoriasis, but it has prac- tically been abandoned on account of its poisonous qualities. Recently Dr. L. von Rekowski, of Berne, has recommended as its substitute this dye-stuff, gal- lacetophenon—a derivative of pyrogallol, and known commercially by the name of “alizarine-yellow C.” It is prepared by bringing a mixture of 1 part of pyro- gallol, 1% parts of acetic acid, and 1% parts of Zinc chloride to a temperature of 145° C. to 150° C. When pure, it occurs in needle-like crystals, which may be incorporated in a very serviceable ten per cent. ointment, which does not stain linen. MATERIA MEDICA, PHARMACY. THERAPEUTIOS. 625 Foreign dermatologists are using this very successfully at present, and among our own practitioners, Dr. Her- man Goldenberg, of New York City, points out its advantages, and recommends its extended use.” Clycerin Suppositories have met with increasing favor in the treatment of some forms of rectal inertia and weak peristaltic action, particularly of the lower intestinal tract. Many formulas are in use, but the one which gives the best satisfaction, according to Prof. J. P. Remington, of Philadelphia (President of the American Pharmaceu- tical Association), is as follows: Sodium Carbonate, . ſº . 2.6 Grammes ( 40 grains). Stearic Acid, & e d . 5.2 & 4 ( 80 “ ) Glycerin, . ſº g e . 70.0 & g (1080 “ ) Cuaiacol—the beechwood-tar product containing a maximum of 90 per cent. creasote—has been in remark- able demand during the past year. At one time it seemed as if the manufacturers could not supply the unusual calls upon them, and an inferior article was offered for sale with customary failures in expected results. Its use, together with that of its salts, has been largely, if not wholly, confined to the treatment of pulmonary tuberculosis. Of all the agents used for this affection there is probably none which has proved so uniformly beneficial. It has been constantly increasing in favor from its very introduction many years ago, and it is now, perhaps, more generally used for this affection, in every country in the world, than any other agent. The ben- Zoate, salicylate, iodide and carbonate—all have found their use in individual practice, but none of these has been given more attention during the past year than the Carbonate. The irritation produced by guaiacol as well as by crea- Sote is, in some cases, Sufficient to preclude the use of 1 N. Y. Med. Jour., Vol. 55, p. 153. 40 626 NEW YORK STATE MEDIOAL ASSOCIATION. either, and therefore Drs. Richard Seifert and Fritz Hölscher proposed to overcome this difficulty by substi- tuting the carbonate—obtained by passing chlorine and CO2 gases into a mixture of guaiacol and caustic soda. The product is a tasteless and odorless crystalline pow- der, insoluble in water. In a healthy stomach it apparently is not split up—re- maining unacted upon until it reaches the intestine—and therefore it does not disturb the digestion. In an hour after administration it may be detected in the urine. According to the above observers the initial dose to be used is from 20 to 60 milligrammes (about 9% to 1 grain), and increased up to a maximum of 6 grammes (about 90 grains). No disturbance of the digestion, circulation or nervous system was noted from even the maximum dose. Out of four cases upon whom the carbonate was tried, two had taken creasote, and one guaiacol itself with trifling benefit, but were manifestly improved by the carbonate. Again, other cases taking the carbonate reg- ularly and improving, lost in weight and in general con- dition when put upon creasote. Dr. Francis P. Kinnicutt, of New York City, has given us the most complete comparative results that we have at the present time, in regard to this carbonate, guaiacol itself, and creasote." His notes are very full and inter- esting, and were alluded to under the head of Creasote. Haemogallol is the haemoglobin of the blood oxi- dised by the action of pyrogallol, thus furnishing a new compound more easily assimilated, and more readily supplying those ingredients of the blood which are found lacking in such affections as chorea than the ordinary iron preparations so universally prescribed. Professor Kobert, of Dorpat, was the first to give at- tention to this subject, and as far as he has gone he has met with gratifying results. It is a brownish-red powder, and has been patented, which latter condition will unfortunately limit any im- 1 N. Y. Med. Record, Vol. 41, p. 561. MATERIA MEDICA, PHARMACY. THERAPEUTICS. 627 mediate chance it might have of usefulness by reason of the accustomed restrictions of any enterprising firm who gains possession of the patent rights. It is given in doses from 100 to 500 milligrammes (1% to 7% grains), shortly before each meal, in any conven- ient vehicle which will not retard its rapid absorption, or it may be given in capsules. The digestion is not dis- turbed, and the anaemia disappears more rapidly than under the usual form of treatment, although the quantity of iron thus introduced only amounts to about 10 to 15 milligrammes daily. Professor Kobert considers this the great advantage this agent possesses over the usual iron preparations. Of course, too short a time has elapsed since its intro- duction to expect to see reports of much clinical experi- ence, but no doubt we will hear more of this article later. Haemol is a closely allied preparation to haemogallol (just spoken of), and is obtained by the same process, except that the reducing agent used in this case is zinc– presented in the form of a fine dust, and shaken up in the presence of water. By this process, after proper separation, a slight trace of the zinc is retained in the resulting dark-brown, almost black, powder—haemol. The zinc present theoretically appears to act efficiently where there are lesions of the stomach or intestines which tend to break down into ulcers. Given in this compound, the zinc seems to lose its caustic effect, and does not pro- duce nausea. The dose and mode of administering haemol are the same as for haemogallol. Helenin, the white acicular crystals obtained from the root of Inula Helenium (Elecampane Root), which has received some attention from foreign observers in the treatment of tuberculosis, does not appear to pro- gress very rapidly, owing chiefly to the cost of pro- duction. The crude article is a very effective antiseptic and has been much used on the Continent as such. 628 NEW YORK STATE MEDICAL ASSOCIATION. In Spain it is favored as a surgical dressing. Ferran claims that it is more destructive to the cholera bacillus than any other agent. It has been used successfully in OZaena, and internally in malarial fevers, diarrheal troubles and leucorrhoea. Dr. M. Hamonic reports excellent results in the latter affec- tion after internal use. He states, however, that it is a failure locally, as it irritates the vaginal mucous mem- brane. Parisot corroborates Hamonic after its successful employment in twenty-seven cases. The cost has been greatly against it, especially in regard to the pure article, and although Dr. T. J. Boken- ham, of St. Bartholomew’s Hospital, has been very suc- cessful in his experiments on animals, he has not been able to push it very far in his practice, as considerable quantities have to be used and its use has to be continued over an extended period in each case. Dr. Bokenham’s investigations were very carefully made and deserve attention.” Hydrastinin is the oxidation product of Hydrastin, one of the alkaloids found in the root of Hydrastis Canadensis (Golden Seal). It has been used now for about two years with increasing professional popularity, particularly among the gynaecologists. A stimulus to its increased employment has been recently furnished in a reduction of the price, and thus a more extended use may be expected. The hydrochlorate is mostly used, and the salt appears to act as a haemos- tatic, contracting the blood-vessels of the endometrium. It cannot take the place of ergot, as it does not cause contraction in the muscular tissue, and can act most effectually only upon a relaxed uterus, as the blood- vessels are then in a condition free to contract. Although its haemostatic action is very pronounced in over half the number of cases tried, still it appears to be uncertain, and in fact may have no effect whatever, SO that from all the testimony given by a now numerous Set * Brit. Med. Journal, Vol. 2, for 1891, p. 838. MATERIA MEDICA, PHARMACY. THERAPEUTICS. 629 of observers, principally in Germany, it cannot by any means show any advantages over the officinal fluid extract of hydrastis, given in proportionate quantity, which is a small dose, even at the maximum. Hydrogen Dioxide (Peroxide of Hydrogen) has been used much more largely during the year past. The more that is learned, both as to its applicability and as to its mode of preparation and keeping qualities, the more reliable will be the therapeutical results, and the less ad- verse criticism from unnecessary failures will be heard. Its range of usefulness also has been somewhat ex- tended since last year. In illustration, Dr. Altehoefer recommends it as a disinfectant of polluted water. His researches tell him that one part per thousand of water containing sewage or infectious microbes, is quite suffi- cient to destroy the various organisms if left to act for twenty-four hours. Used in drinking water it does not make it in the least unpotable, and the proportion of the agent needed is so Small, that the cost is inappreciable. It has had quite an increasing use as a cleansing agent for foul wounds, abscesses and the like. It is found to be a valuable diagnostic agent in deter- mining the presence of pus, for Stuver found that when injected into a part in which suppuration was suspected, it would indicate its presence by causing an almost imme- diate swelling up of the part. If such a discovered spot was at once cut into, pain was avoided. He treated a num- ber of suppurating buboes in this way with great success. Dr. F. H. Wiggin, of New York City, desires the pro- fession to try it in the treatment of typhoid fever, as he has had one very successful case, in which he “prescribed One ounce of a fifteen volume solution of peroxide of hydrogen to eight ounces of water, to be taken every three hours, by the mouth.” He is fully alive to the fact that his one case cannot prove anything, and there- fore urges others with more frequent opportunities to try it and report their results." 1 N. Y. Med. Record, Wol. 40, p. 658. 630 NEW YORK STATE MEDICAL ASSOCIATION. During the year it has been the chief work of the manufacturing chemists in this line to either improve the process, or to discover some agent to add to the finished product that will render its keeping qualities far better than they are at the present time. The presence of a free acid appears to be absolutely necessary in all solutions of this article, since without this, careful; comparative tests have definitely proven that decomposition is rapid ; but much free acid protects no better than a little, while it renders the solution and its dilutions hurtfully irritant to diseased and sensitive surfaces. Boroglyceride in small proportion acts fairly well as a preservative, but still decomposition occurs, and chiefly upon agitation. Dr. S. S. Wallian, of New York City, has recently intimated that this article can be made stable, and if this be true, he knows more than all the investigators before him, and we think he owes it to the profession to either divulge his method of preparation, or present some of the product for critical tests. If he has suc- ceeded in accomplishing what he intimates, it will be an inestimable boon to the whole community, as this is rapidly coming to be a most important remedial agent in the hands of practitioners in every quarter. lchthyol (Ammonium Ichthyol-Sulphonate) is one of the newer remedies which has been able, since last year, not only to hold its own, but has increased its sphere of usefulness. Among foreign observers, Drs. Klein and S. J. Rad- cliffe now ascribe almost specific properties to it in the treatment of erysipelas. Dr. C. W. Allen, of New York City, continues to give as favorable reports of its use as he made a year ago. It has had its largest use in eczema, erysipelas, and all forms of rheumatism. Its more extended use is reported by Eschen, in the treatment of twenty-five cases of uterine complaints, including metritis, parametritis, and inflammation of the Ovaries. MATERIA MEDICA, PHARMACY. THERAPEUTICS. 631 One fatal case from its use has been reported by Dr. Bergerio, at a meeting of the Turin Academy of Medicine, in which “he was washing out the uterus of a woman, suffering from endometritis, who on the previous day, had had her uterine mucous membrane curetted with a solution of one-third ichthyol to two-thirds glycerin. Almost as soon as the washing out began, she complained of a putrid fish taste in her mouth, the pulse became like what it is in tachycardia, and symptoms of general depression came on which lasted for about twelve hours. Bergerio believes that the rapid absorption could only have taken place through the recently scraped uterine mucous membrane. He stated that it was the first accident of the kind occurring in his hands, in an experience of about one hundred cases, in which he had used this agent in utero-ovarian disease. He did not know whether it was to the ichthyol-sulphonic acid part of the salt, or the base ammonium that the symptoms were due. In discussing the case, Giacosa said toxic symptoms caused by ammonium were referable to the spinal cord, and therefore he had no doubt that, in the present instance, it was the acid part that was respon- sible. Peroni cited the case of a woman under his pro- fessional care to whom he gave as much as 5 grammes (about 75 grains), daily, for prurigo, without any untoward effect, until one day being told that it was obtained from “fossil fish ’’ (?), she was seized with vomiting, headache, convulsions and diarrhoea. Replying to this reflection, Bergerio said the element of suggestion was excluded in his case from the fact that she was ignorant of the nature of the medicament which was being given to her for the first time. lodoform—prepared by the action of chlorinated Soda on acetone in the presence of an iodide—has appar- ently lost little during the past year from the attention paid to its increasing number of rivals. Its great draw- back—an extremely disagreeable, penetrating and per- sistent Odor—has undoubtedly been the means of dis- 632 NEW YORK STATE MEDICAL ASSOCIATION. couraging its use somewhat, but its efficiency is so marked wherever it is applicable that the disagreeable odor is simply endured. The expedients used to dis- guise this odor still accumulate and will continue to be sought after until more desirable results are reached than we possess now. A few prominent expedients out of the many suggested during the past year may be alluded to here : When application is to be made to the skin, Camphoid (spoken of under its proper head) makes a very service- able agent. The volatilisation of the excess of camphor serves to mask the iodoform odor. Terpineol—the chemical name for the perfume Lilacin found in several essential oils—imparts the odor of lilac, and is claimed by some to answer better than all others. A stick of menthol enclosed in a well-stoppered bottle about half filled with iodoform is said to render the latter inodorous after being thus enclosed together for One or two hours. Carbolic Acid, wº wº tº & & g g 1 part. Peppermint Oil, . & tº e * g º 2 parts. Iodoform, tº & o g { } º g . 197 parts. is reported to work effectively. Essential oil of coriander has lately been employed in the proportion of 8 drops to 4 grammes (one dram). It should be thoroughly mixed by trituration. Finally, cumarin (the active constituent of tonka bean), especially that artificially made, is also recom- mended for almost entirely disguising the odor, and for rendering it more agreeable as well by its own aromatic odor. - lodophenin—the combination of iodine with phe- nacetin, containing 50 per cent. of iodine—has been practically unheard from in this country during the past year, and rather flat reports come from abroad. Some favorable results come from the Paris Charity Hospital, but elsewhere observers generally agree with Dr. Siebel’s conclusions that it gives off iodine in excess MATERIA MEDICA, PHARMACY. THERAPEUTICS. 633 too readily and no specific action can be attributed to it which iodine uncombined does not furnish. lodopyrin—the chemical combination first prepared by Dittmar, and obtained by replacing one atom of hydrogen in antipyrin by one of iodine—has not been used as universally as was expected. The observation that its colorless, silky, needle-like crystals were only slightly soluble in cold water, thereby rendering it prac- tically tasteless, and that it was odorless, gave abundant promise of a future for its use, but aside from favorable results in a few cases of typhoid fever reported by Dr. Egmont Munzer in the clinic of Prof. R. R. von Jaksch, little is heard of it favorably. He also reports its use in pulmonary tuberculosis, where profuse diaphoresis was produced in conjunction with rapid reduction of temper- ature to the normal. Theoretically it is split up into its component parts in the stomach. lodozone is the name given by Robin to a solution of iodine in Ozone. The solution appears to be a com- plete one, as no free iodine can be detected. The bene- ficial expectations were first suggested by the well-known value of pure sea air—containing traces of iodine (!). It is recommended to be used as a spray in pulmonary tuberculosis, and on Open wounds. Ipecacuanha has again been alluded to as useful, in cases of obstinate haemoptysis. A well-founded case is now recorded where ergot and gallic acid utterly failed and ipecac was effectual. Its administration must be pushed to the point of producing nausea, as that condi- tion is necessary to produce the desired effect." Jambul (Jamun)—the seeds and bark of the Eugenia Jambolana, a native tree of India—is rather in a mixed state in regard to its proper position as an efficient rem- edy in diabetes. Very conflicting testimony has been reported, both from this and foreign countries; but since the authorisation of the British Medical Association, * Gaillard's Med. Jour., Vol. 53, p. 482. 634 JNETW YORK STATE MEDICAL ASSOCIATION. given to its Therapeutic Committee to investigate it thoroughly, a more strictly scientific turn has been given to more general observations among the profession. Dr. Sidney Martin, 10 Mansfield street, London, W., Secre- tary of the Committee, invites all to coöperate in this inquiry. In keeping with this systematic spirit now awakened, Dr. Thomas Stephenson, F. C. S., of Bombay, read an interesting paper at the recent British Pharmaceutical Conference, held in Edinburgh, in which he very defi- nitely concludes that any preparation of jambul, as the fluid extract, should be made from the fresh seeds, dis- carding the pericarps and avoiding the application of heat. He also finds that a weak alcoholic menstruum exhausts the drug and gives a stable preparation. The conflicting results heretofore reported may have been due to a failure to follow the above plan of prepa- ration, and not due, as some have stated, to the fact that under the name of jambul are known a number of differ- ent plants in India, and thus sophistication practiced. This latter explanation of failure to obtain uniform therapeutical results is refuted by Mr. G. Bidie, of Ros- neath, England, as he states that the Eugenia Jambolana is very widely dispersed and common in most jungles of natural growth, and it would in most cases be more difficult for the dealers to get the spurious than the genuine seeds. At some future date, then, we may confidently look for the results of very definite scientific investigations. Lysol—the saponified product of coal-tar, chiefly com- posed of the cresols—has been widespread in its useful- ness during the past year, particularly abroad. No doubt the cholera epidemic has contributed largely towards its consumption. Notwithstanding its widespread use and undoubted efficacy, it is not the me plus ultra which was claimed for it in the beginning. The conclusions for the year are best summed up by MATERIA MEDICA, PHARMACY. THERAPEUTICS. 635 Cadéac and Guinard, who have made a series of experi- ments with it : It is superior as a microbicide to carbolic acid, creolin, cresyl and other analogous tar-products; It has not, however, any advantages over the antiseptics of established reputation ; It is only really efficacious when used in solutions which may be irritating or caustic ; Although not destined to play a great part in Surgery, it may often be useful in the prophylaxis and arrest of epidemics; It is likely to be particularly serviceable in the disin- fection of premises, privies, ships and stables; It is readily soluble, reasonably active and very cheap. Methacetin (Para-Oxy-Methyl-Acetanilid) is the colorless scaly crystals introduced by F. Mahnert in 1889 and which promises to supersede phenacetin. It derives its name from its analogy to phenacetin. The graphic formulas of these compounds show at a glance the close relationship, but it will suffice here to state simply that methacetin differs from phenacetin only in containing a methyl group in the place of an ethyl group ; phenacetin is oxy-ethyl-acetanilid and metha- cetin is oxy-methyl-acetanilid. It has been used successfully in typhoid fever, all forms of rheumatism, neuralgias, pneumonia, and in pretty much all forms of pyrexia, but from the record of the past year it has not yet equaled the results obtained by either phenacetin or antipyrin. Its use in pulmonary tuberculosis was not favorable, principally on account of the profuse night sweats produced. Its advantages over all the other antipyretics, how- ever, are its lack of poisonous properties and its com- paratively ready solubility in water, being five times more soluble than phenacetin—its greatest rival. Methylene Blue (Tetra-Methyl-Thionine Chloride) —the anilin derivative—not Methyl Blue, has secured a more important place in the attention of observers dur- 636 NEW YORK STATE MEDICAL ASSOCIATION. ing the past year. Formerly the commercial form only was to be obtained, and that consisted of a double chlo- ride of zinc and tetra-methyl-thionine, but by purification’ the zinc was eliminated, and now the agent freed from this should only be asked for. The pure form is seen in small, dark blue, scaly crystals with a copper bronze tinge, soluble in water. Just as Ehrlich and Leppmann previously reasoned that as this dye manifested an affinity for nerve tissue, and especially for the axis cylinders of sensor nerves, it might prove to possess anodyne properties when intro- duced into the system for neuralgias and rheumatic affections, so in like manner the observation that it is the best staining agent for the microbe found in malaria, has suggested that it might act effectively in malarial affec- tions. Thus Guttmann and Ehrlich took up the matter and confirmed the expectation in two cases. Under this treatment there is an increase of urine (colored from a green to a deep blue, depending upon the length of ex- posure to the air), and some strangury noted, but no albuminuria. The faeces do not show the blue color at once, as the methylene blue is apparently present there in a reduced form, for upon oxidation by contact with the air, the blue color is gradually developed. The strangury was treated by giving small doses of powdered nutmeg several times a day. This is apparently a remedy often used in the south of Germany, to relieve the uncomfortable feeling after drinking an excess of new beer. In our own country, Dr. John H. Huddleston, of New York City, has treated three cases of malaria in children successfully with this agent. No relapse followed. Again, Dr. W. S. Thayer, Resident Physician to the Johns Hopkins Hospital, Baltimore, Md., reports' on its value in this affection, giving an account of his seven cases, with temperature charts. He summarises as follows: 1 Bulletin of the Johns Hopkins Hospital, 1891, Vol. 3, p. 49. MATERIA MEDICA, PHARMACY. THERAPEUTICS, 637 1. It “has a definite action against malarial fever, accomplishing its end by destroying the specific organ- ism ; but it is materially less efficacious than quinine, failing to accomplish its purpose in many cases where Quinine acts satisfactorily. 2. The action appears to be rapid, the chills disappear- ing, or the temperature in the remittent cases, falling to normal during the first four or five days; but later, however, if a sufficient number of organisms have re- sisted the drug, they appear to develop again directly under its influence, causing a return of the symptoms.” 3. It “seems to have no advantages over quinine, which would warrant its further use.” From abroad, Dr. G. Mya reports, in the same line of treatment, on nine cases treated in the Ospedale di Santa Maria della Scala, at Siene, giving substantially the same results as those of Dr. Thayer. He even goes further and states that by reason of its uncertainty and the discomfort and even suffering frequently caused when used for this affection, he would express “the most absolute reserve with regard to its practical appli- cability.” Bourdillon details three cases of malaria successfully treated with it, in two of which quinine had previously failed. In using it for other affections, as neuralgia, gonorrhoea, and tuberculosis, he remarks that perhaps it is the malarial form of neuralgia in which it is of most benefit. No effect was produced in tuberculosis, and he even suggests that in doubtful cases it might be em- ployed to distinguish tuberculosis from malaria. Finally, Dr. G. Lava reports on two cases of malaria without success, and concludes as follows: 1. It has no certain effect in this affection even after five consecutive doses ; 2. Its action appears to be limited to a temporary lowering of the maximum temperature, followed, how- ever, later on by exacerbation and by shortening of the period of intermission ; 638 JWEW YORK STATE MEDICAL ASSOOIATION. 3. The plasmodia are not only not destroyed, but not even modified. 4. The enthusiasm of Guttmann and Ehrlich, above spoken of, is somewhat premature. It will thus be seen that opinions differ somewhat as to its use in malaria, although it may be well used at times as an alternate to quinine. Among the other affections in which it has been em- ployed Taube and others have used it successfully as a local application in diphtheria in the form of a ten per cent. solution, and Dr. Joseph N. Henry, of New York City, reported at a meeting of the New York County Medical Association, some months ago, his successful use of it in two patients suffering from chronic cystitis. He presented some of the characteristic blue urine for examination. Monochlorphenol is about the newest preparation suggested for the treatment of pulmonary tuberculosis. It is very little known as yet outside of Italy, where the local physicians have been experimenting with it at the suggestion of its introducer, the chemist Tacchini, of Pavia. It is prepared by the action of chlorine gas upon phenol with the temperature kept low while the reaction is going on. In fact, the completed preparation must be kept at a moderately cool temperature up to the time of using it, for theoretically it is to its extreme volatility that it owes its beneficial effects, as the heavy vapor given off is supposed to be destructive to the bacilli in the lung tissue. It is also recommended to be inhaled for various affec- tions of the respiratory passages, but especially for pul- monary tuberculosis. We shall hope to hear something more definite of the clinical reports before long. Naphthalin (Naphthalene) is a hydrocarbon product formed during the manufacture of ordinary coal gas. When redistilled, it crystallises in colorless rhomboid MATERIA MEDICA, PHARMACY. THERAPEUTICS. 639 plates with a slight tarry odor. It is insoluble in water. It is seen frequently in the form of moulded blocks under such names as Alabastrine and Camphylene for preserving furs and flannels from moths, and also placed in urinals for disinfecting purposes. It has been used also internally for some years past in dysentery, all forms of diarrhoea, and somewhat as a substitute for iodoform, but recently it has received more prominence as a vermifuge and in the treatment of pertussis. A Russian—Dr. Coriander, of Samarcand— many years ago published the fact of its value for taenia and ascarides, but it is only during the past year that another Russian practitioner, Dr. Mirowicz, has called attention to it again, and urged its more general use. He claims for it, not merely that from its very character it excludes the possibility of all unfavorable symptoms, but that it is also thoroughly reliable in its anthelmintic properties. He has given it for all kinds of intestinal worms, and invariably obtained not only prompt but complete results. Tape-worms were removed entire by a single dose of one gramme. Adults are ordered a dose of castor-oil to follow the naphthalin, but for children it is preferable to give both together. Of its use in pertussis, it no doubt will be interesting to some to read what the London Lancet has to say in its Annotations on the published paper of Dr. Chavernac, of Aix: “Many remedies have been vaunted for the cure of whooping-cough, but with little satisfactory results in the great majority of cases. A proposal to add naphthalin to the long list of so-called cures has arisen in the following manner: Dr. Chavernac, of Aix, during a recent epidemic, seems to have allowed his son, who was eighteen years of age, while suffering from the affection, to continue to attend school. One day the lecturer on science heated some substance which gave off very strong fumes, which, though disliked by many Of the boys, had the effect on him of immediately stop- ping a violent attack of coughing. As soon as the win- 640 NEW YORK STATE MEDIOAL ASSOOIATION. dows were opened and the fumes passed away, the cough recommenced as violently as ever. His father having discovered that the fuming substance was merely naph- thalin, had about an ounce of it burnt in the lad’s bed- room, with the result that he breathed a great deal more easily, and only had one slight attack during the night. The next day, being at School, he had several attacks, but they were somewhat less severe than they had been previously. The next night the drug was again burnt in the bedroom, and this second dose entirely cured both the cough and the expectoration, which latter had been rather profuse. The father was then attacked, and in three days cured himself by the same treatment. He subsequently tried it with several of his patients with marked success, and with the concurrence of a friend, who was medical officer to a convent school where the epidemic was raging, he tried it on thirty affected chil- dren. After the naphthalin had been burnt two success- ive nights in their dormitory they were all cured. Two of the nuns, however, found the fumes very irritating, and on these ladies being examined it was discovered that they were both suffering, quite unknown to themselves, from incipient phthisis. From this and some further observations Dr. Chavernac has come to the conclusion that naphthalin is contra-indicated in phthisical persons, and that it may sometimes serve to reveal the existence of totally unsuspected tubercle. It may be remarked that the so-called albocarbon used frequently for enhanc- ing the lighting power of gas is somewhat crude naph- thalin. The method employed by Dr. Chavernac is to place about three-quarters of an ounce in a metal dish surrounded by hot coals. It soon melts, and before long fills the room with white fumes, which he considers by no means unpleasant. The old custom of taking children to gas-works for whooping-cough has gener- ally been thought to depend on the curative effect of gas-tar; but from the above it would appear that the naphthalin which crystallises out in the retorts and MATERIA MEDICA, PHARMACY. THERAPEUTICS. 641 pipes is perhaps really to be more credited with efficacy than the tar.” Since the publication of Dr. Chavernac's paper, Dr. Ivanoff has fully confirmed these results, but insists that the treatment must be more thorough and prolonged. He says he has treated all his cases of pertussis thus for several years past, the results being invariably excellent. He demands, however, that it is absolutely necessary that the patient should inhale the fumes continuously day and night until the treatment is complete. In very severe cases he at times resorts to the use of sodium or potassium bromide internally, in addition to the naph- thalin fumes. Naphthol (Naphthyl Alcohol) is the coal-tar deriva- tive seen in the Sublimed, colorless, shining, laminar, crystalline product, properly known as ſº-naphthol. This has been in use for both internal and external ad- ministration in a great variety of affections for more than a decade. Within the last year or two the a-form—a-naphthol— has also been recommended as a marked antiseptic. It apparently is more soluble and more efficient than £3- naphthol, and possesses about one-third its poisonous properties, but is more irritant. A solution of about 300 milligrammes (about 34 grains) to 1 kilogramme (about 24 pounds) of water has been used to wash out the intestines. Although the use of the two naphthols has been pretty steady from the beginning, they have been superseded somewhat by their near allies and deriv- atives, such as Benzonaphthol, Betol, Hydronaphthol, Iodo-Naphthol, Microcidin, Naphthol Camphor (cam- phorated naphthol) and the like. The latter, although now over two years old, has apparently taken a fresh Start into prominence. This is prepared by heating carefully one part of £3- naphthol with two parts of finely powdered camphor, until a homogeneous melted mass is obtained which is of an oily consistency, insoluble in water. It should be 41 642 NEW YORK STATE MEDICAL ASSOCIATION. kept well stoppered in dark colored bottles, as it readily decomposes on exposure to air and light. Since the first report of its use hypodermically by Dr. Jules Reboul, of Marseilles, France, in the treatment of twenty-seven cases of tuberculous glands, with only six cases which did not show permanent improvement, he has reported to the Paris Société de Chirurgie five more. Out of the whole thirty-two cases, thirteen improved perceptibly, but nineteen improved permanently. David afterwards reported in an inaugural address fifteen cases —Six of which simply improved, but nine improved per- manently. The tuberculous adenitis did not entirely disappear in all cases, but there could be no doubt as to the remarkable improvement and favorable modification of the condition. - Dr. Reboul has since treated five cases of tuberculosis of the testis, with very gratifying results. The treat- ment appears to be perfectly harmless, and acts bene- ficially both locally and generally. It has had an extended use now in irrigating joints, bony cavities, tendonous sheaths, cold abscesses in the pleural and uterine cavities, and also in cases of tuber- culosis of the bladder. All these localities seem to bear well the undiluted fluid. Finally, naphthol and all its derivatives cannot be said to have superseded carbolic acid, although they no doubt will find a permanent place on the list of valuable agents. Orexin Hydrochlorate (Phenyl-Dihydro-Quino- Azoline) a year ago did not give much promise for the future, and it apparently has gained little since that time. To be sure there are several who have re- ported enthusiastically upon its use, but it is contra- indicated in so many ways that its limit of usefulness is necessarily restricted. - - An Italian observer, A. Rizzi, has recently taken up its study, and acknowledges that many conflicting State- ments have been made by different observers as to its action, and that there is a strong tendency to disbelieve MATERIA MEDICA, PHARMACY. THERAPEUTICS. 643 the claims originally made for it. His new research en- courages one to believe that it may be of marked benefit in certain cases of failure of appetite. He employed it first on healthy subjects, and then on those with various gastric disturbances. In the first class he found with Prof. Penzoldt, of Erlangen (spoken of last year), that it caused the appearance of a keen sense of hunger, and produced increase both of the secretory energy and of the peristaltic movements of the stomach. In cases of atonic dyspepsia, complicated or not with chlorosis or anaemia, he appears to have been equally successful with Prof. Penzoldt, and to have obtained some very striking results. He suggests that failure to obtain benefit has probably been due in many cases either to the unsuita- bility of the case, or to the fact that the salt used was not pure. Gastralgia or hyperaesthesia of the gastric mucous membrane should, however, always be taken as a contra-indication to its employment, as in such condi- tions it may do more harm than good by its irritant action. He recommends giving it in the powder form, enclosed in wafers, to be followed immediately by a few swallows of water or broth to prevent it from remaining confined to one locality of the stomach, and thus pro- ducing too much irritation at that spot. Ouabain is a glucoside obtained by extraction from the root and wood of the ouabaio, growing in Africa, and used there as an arrow poison. It is sold in small pearly tabular plates, without odor, only slightly bitter, and completely soluble in boiling Water. - Over a year ago Dr. Gemmell, of Glasgow, published his successful results with it in pertussis, and believes it to be of marked benefit in all stages of the disease. For a child under five years he gave six-hundredths of a milligramme (Tºry grain) every third hour, in Solution. Stimulated by these results, Dr. J. Lindsay Porteous, of Yonkers, N. Y., undertook to test it, and with very gratifying results." *New York Med. Jour., Wol. 54, p. 345. 644 MEW YORK STATE MEDICAL ASSOCIATION. It had been used to some extent as an anaesthetic in the eye, but had not previously been found to be as efficient as cocaine. However, within the past year Dr. Joseph Sailer, of Philadelphia, reports through the Therapeutic Gazette, that he found it superior to cocaine as a local anaesthetic. He has given an instructive series of conclu- Sions based on his experiments on animals, a crude Out- line of which may be of interest here: It causes a slow- ing of the pulse, due to a stimulating action upon the cardio-inhibitory function, and possibly in part to a direct action upon the heart muscle. Along with this action there is a primary vaso-motor spasm, due to an action upon the vaso-constrictor fibres or the muscular coats of the vessels. The slowing of the heart may be SO pronounced in exceptional cases as to overcome the vasomotor spasm and cause a fall of pressure. This is at once followed, first by a great increase in the pulse rate, caused by depression, and secondly, by paral- ysis of the vagi and increase in pressure, due partly to increased heart action, and partly to continued stim- ulation of the vaso-motor system. Finally, the heart muscle becomes paralysed, and the pressure rapidly falls to Zero. Therapeutically it may be classed as a potent emetic, especially when given hypodermically. Defecation is promoted, possibly by increasing the peristaltic action. With great uniformity, it causes increased urination, either by increasing the blood pressure, or by paralysing the sphincter. The temperature of the body does not seem to be affected. Whether this agent will ever be of any practical value, yet remains to be determined. Very small doses give some evidence of a possible action similar to digitalis, but if any great value is to be found in it, it will prob- ably come from its potency as a local anaesthetic, as it appears to be superior to cocaine in this respect. It must be borne in mind, however, that it is an extremely active poison. MATERIA MEDICA, PHARMACY. THERAPEUTICS. 645 Paraldehyde is still hampered by the same objec- tionable features (taste and odor), previously noted, and any progress made towards its more general use during the past year has been in spite of its drawbacks. For the purpose of ready reference, it may be well to repeat here that it is the colorless liquid (at ordinary temperatures), obtained by treating Aldehyde with dilute sulphuric or nitric acid, and aldehyde is the oxidation product of alcohol just preceding the formation of acetic acid. Since paraldehyde was introduced by Cervello, of Palermo, in 1884, it has had a steadily increasing use, there being remarkably few recorded cases of acute poisoning, and a still smaller number of chronic poison- Ing. One case under treatment by Dr. Thos. Mackenkie, of Douglas, Isle of Man, recovered after thirty-four hours of sleep, from a dose of 99 grammes (34 ounces), and furnished “a striking testimony to the safety of paralde- hyde as a hypnotic.” Several cases of tetanus have been successfully treated with it of late, and it has given much benefit in the insomnia of insanity and the milder forms of mania. Most insane asylums now include this agent among their indispensables. Dr. J. Cockburn Syson, of Beith, N. B., has recently given testimony' to its usefulness as a diuretic as well as hypnotic : “In a case of senile arterial degeneration with considerable mental depression, restlessness, marked insomnia, and where there existed a double aortic mur- mur, with a mitral regurgitant and enlarged left ven- tricle,” he was induced to try it “after unsatisfactory results from sulphonal, urethane, chloral, etc.” The insomnia “was most intractable, and of all the hypnot- ics used, with the exception perhaps of opium, paralde- hyde on the whole gave the most satisfactory results, and can be used where it would be decidedly risky to * London Lancet, Vol. 2 for 1892, p. 195. 646 JWH) W YORK STATE MEDIOAL ASSOOIATION. push the older drug.” To sum up, then, this agent “may be looked to as a fairly reliable and safe hypnotic, that its administration is followed by a well-marked stage of excitement, that it does not depress the heart’s action, does not interfere with the appetite or digestion, possesses probably diuretic properties, and induces a sleep which is described as ‘refreshing.’” Pental (Tri Methyl-Ethylene) is the anaesthetic used many years ago, under a slightly different form, con- dition and name, and finally abandoned, but recently restored to usefulness by Prof. J. von Mering, Director of the Medical Policlinic in Halle. It takes its name from having five carbon atoms in its composition. It is obtained by distilling ordinary fusel oil from zinc chloride after digestion with it for twenty-four hours. It is a colorless liquid, very volatile and inflammable. It is insoluble in water, and has an odor resembling mustard. It is administered like chloroform, and requires only 20 cc. (about 54 fluidrachms) to produce in three to four minutes an anaesthesia which, though not deep, is com- plete enough for minor operations, such as extraction of teeth. After administering it in one hundred cases, it was found to be perfectly free from danger, and was fol- lowed by none of the unpleasant after-effects of either chloroform or ether. Even alcoholic subjects take it well. The narcosis produced is not so deep as that after the use of ethyl bromide, but it is far safer. It is not necessary to push its administration to loss of conscious- ness, as loss of sensation is produced before that stage is reached. There are now on record the reports of many observers, each having his series of successful cases. Among them may be mentioned Dr. Weber, reporting 200 ; Prof. L. Holländer, 400 cases of minor operations about the jaw ; and Dr. R. Breuer, of Vienna, with his 120 dental opera- tions. The latter had one fatal case, and there have been a few others reported, but their proportion to the successful ones is extremely small, and it would Seem MATERIA MEDICA, PHARMACY. THERAPEUTICS. 647 that most, if not all, of these fatalities would have occurred with any of the other anaesthetics. A few foreign operators claim that they cannot succeed with it at all, and are at a loss to explain the reason for the success of the majority, but the unsuccessful ones are so comparatively few in number, that they may be recognised practically only so far as to invite investiga- tion for some unusual cause. Phenacetin (Para-Acet-Phenetidin), the acetyl com- pound of phenetidin (the ethylic ether of para-amido- phenol) occurring in shiny white laminar crystals, is well known to every practitioner by this time. Its efficacy is unquestioned, and during the past year it has not only repeated its favorable impression, but has extended its almost unbroken successful course. In the treatment of influenza it has had its largest and most favorable use, giving gratifying results almost invariably. Fatal cases do still occur, but very infre- Quently. It may be useful, although the observations were made over three years ago, to repeat here the results of “The Comparative Value of Antipyrin, Antifebrin and Phena- cetin as Antipyretics,” reported" by Dr. A. Crombie, Surgeon-Superintendent to the General Hospital at Cal- cutta, India, as they are not only none the less true to- day, but have been abundantly confirmed and strength- ened. The result left on Dr. Crombie's mind as the out- come of his observations upon seven consecutive cases were as follows: . “First—As regards efficacy, antipyrin comes first, and there is little to choose between antifebrin and phe- nacetin in the doses in which I have prescribed them. “Second—That as regards safety, the advantage lies With phenacetin. I have never seen a sub-normal tem- perature result from the use of that drug. I have seen Subnormal temperatures as the result of the use of anti- 1 The Practitioner, Vol. 43, p. 266, 648 JNE W YORK STATE MEDICAL ASSOCIATION. febrin, but never collapse, which I have once seen from the use of antipyrin. “Third—As regards rapidity of action, antipyrin, probably on account of its solubility, comes first, anti- febrin second, phenacetin third. The fall after the use of phenacetin is more gradual, and the minimum is not reached for three, four, or even five hours after the administration of the drug. “Fourth—As regards duration of effect the advantage lies with phenacetin. * “Fifth–As regards certainty of action, I would quote them in the same order as that of rapidity—antipyrin, antifebrin, phenacetin. And here let me give a warning against the use of phenacetin tabloids. They are so hard as to be practically insoluble in the stomach, or at least to be so slowly dissolved that a very small quantity of the drug enters and circulates with the blood at one time, not sufficient to affect the temperature. It should be prescribed either in powder or in lozenges which are Soft and friable. - “Sixth-As regards inconveniences, in the climate of India, phenacetin is followed by just as profuse sweating as either antifebrin or antipyrin, and this, to my mind, is the great drawback in the use of antipyretics, patients having to change their clothing once or twice in a night after the use of any of these drugs. Whether or not an antipyretic will yet be found which will be capable of safely reducing abnormal temperature without causing profuse perspiration remains to be seen, but as yet we do not possess one.” - Pheno-Salyl is the name given to a very recent anti- septic introduced by Dr. De Christmas after experiment- ing for some time at Pasteur's Institute in Paris. It is little more than a mere mixture of Carbolic Acid, about * e º tº g , 9 parts Salicylic “ { { *. e e ſº e . 1 part. Lactic & 4 4 & {} ſº * ſº tº . 2 parts, Menthol { { tº gº º g * . Tº part. MATERIA MEDICA, PHARMACY, THERAPEUTICS. 649 The menthol is added to the combined acids heated up to the point of liquefaction. This mixture is soluble in water to the extent of four per cent. Von Yersin finds that it has almost double the anti- septic effect of carbolic or salicylic acid, and is only exceeded by corrosive sublimate. It is especially effect- ive against the bacillus of anthrax. Sufficient time has not yet elapsed for others to report upon it. Phenocoll (Amido-Acet-Para-Phenetidin) has re- ceived increasing attention during the past year, al- though the competition of such previously known and tried agents as antipyrin, acetanilid (antifebrin) and phenacetin have retarded its advance into the position it seems destined to take in the near future. The hydrochlorate is still the salt most used, although the acetate, carbonate and salicylate are now furnished. The acetate is so readily soluble, that it is well suited and recommended for hypodermic use. Dr. Paul Cohnheim reports his conclusions on a series of cases. In five cases as an antipyretic, he found more chilliness and more sweating than with antipyrin. In twelve cases as an antineuralgic, seven of which had in- fluenza, he reports it as equal to any of the remedies used for a like purpose. He proves it useless in hysteria. In two cases of acute rheumatism it proved serviceable, but had no effect in chronic cases. It proved of no use in two cases of bronchial asthma. He urges further trials in neuralgia, especially when due to influenza. Prof. Peter Albertoni has treated thirty-four cases of malarial fever with this agent. Twenty-four were re- ported cured ; in five there was no effect, and in the remaining five the results were doubtful. The dose in each case was one gramme (154 grains) given in powder Or Solution from five to seven hours before the attack. The attacks were aborted after one, or at the most two, doses, but its use was continued for some days to prevent a relapse. .650 NEW YORK STATE MEDICAL ASSOCIATION. Dr. P. Balzer used it in thirty cases in Prof. Eich- horst's clinic in Zurich with satisfactory results in fifteen, which included cases of typhoid fever, pulmonary tuber- culosis, pneumonia and erysipelas. Dr. Rudolph Bum has also made a careful study of the whole subject, but only partially confirms the results of the previous observers. Others also dissent somewhat from the quite prevalent favorable reports, finding its effect on the temperature quite pronounced, but the duration short ; they would look for its proper field for future usefulness in rheumatic and neuralgic affections. Reports from our domestic observers are still meagre. Phenolid is simply one of the now numerous mix- tures containing fifty per cent. each of acetanilid and sodium bicarbonate. Little is heard of it practically anywhere, especially in this country. Piperazin (Di-Ethyline-Di-Amine)—formed by the decomposition of ethylene-di-amine hydrochloride after heating—has had an extended and almost uniformly successful year. During the later months of 1891 a series of experiments were made by Dr. J. F. Holtz, in Schering's Laboratory, On its action upon artificial urinary calculi, composed of uric acid alone, and of calcium phosphate and of ammo- nium urate, resulting in the observation that all of these concretions were readily soluble in a one per cent. Solu- tion within a comparatively short time. In a few of the trials nothing remained but a honeycombed skeleton of the concretion, consisting of solidified mucus. It was very noticeable that the edges of some very sharp pieces dissolved away quite rapidly. Some months after this, Finzelberg recalled attention to these points at a meeting of the Pharmaceutical So- ciety of Berlin, and offered some suggestions as to its administration and practical working, which may be worth noting. He showed that in order to ensure its complete action in dissolving the concretions in the cir- MATERIA MEDICA, PELARMACY. THERAPEUTICS. 651 culation, it is desirable to retain it in the blood for a considerable time. For this reason, then, it must not be given in pill or powder form, but always in solution. As it is capable of dissolving calculi, composed either of single salts or of uric acid itself, a 3 to 5 per cent. Solu- tion may be applied locally within the bladder, for the purpose of dissolving calculi of mixed composition. It was also pointed out by Dr. Hirsch, at the same meeting, that from his experience, a 1 per cent. Solution applied locally to open gouty sores, relieved the pain and reduced the inflammation. There is little doubt but that piperazin will now be used more largely, as the price has been materially reduced. Pyoktanin (Methyl-Violet)—the anilin dye—still continues to furnish confusing, and many times conflict- ing, results. Observer A, for instance, will publish astonishingly favorable results. Observer B will at once rush into print stating he cannot see how A got such re- sults, as he has been trying the antiseptic on similar cases, and has rarely seen even improvement. Observer C then comes to the rescue of A, and so on, so that if the favorable and unfavorable reports were arranged in tabu- lar form, they would not come far from balancing. The oculists have apparently found good use for pyok- tanin in a limited class of cases, and among others Dr. Flavel B. Tiffany, of Kansas City. He seems to think it especially indicated in deep-seated affections of the eye, especially those of the uveal tract. The laryngologists have met with some success in treating the upper air-passages. Dr. R. P. Lincoln, of New York City, has used it pretty generally in the dis- eases of that locality, and also with many other prac- titioners in diphtheria. With some of the observers’ results, however, it might be difficult to discriminate between the beneficial effect of the corrosive sublimate used and that of the pyoktanin. . It has been used quite generally, particularly abroad, 652 NEW YORK STATE MEDICAL ASSOCIATION. as an injection into malignant tumors, with very diverse results. One successful observer in Paris goes so far as to conclude his remarks with the statement that it may well be discarded entirely “as one of so many remedies which fill druggists’ shops without any advantage to medicine.” Pyridin | e º and may be mentioned here for little else than Pyrodin to call attention to the striking similarity in name— differing only by the vowel in the second syllable. Pyridin has been known for some years as a remedy for the dyspnoea of asthma and in angina pectoris. It is a colorless, liquid, alkaloidal base, forming crystalline salts with acids, and obtained principally from the tar oils by the destructive distillation of bones. It is heard little of in this country. Pyrodin is the name given to an impure hydracetin (acetyl-phenyl-hydrazin), a coal-tar derivative. It oc- curs in the form of a white powder with alleged antipy- retic properties, but the results are so uncertain and variable that it is little sought after. Pyrozone is the name given by a well-known manu- facturer to a concentrated solution of hydrogen dioxide in ether. It professes to contain about 50 per cent. Of the dioxide, and is a very potent and efficient oxidiser, intended for external use only. It has abundant appli- cations known to most surgeons. Quickine is the trivial, thoroughly unscientific, and catchpenny name given to a so-called “new antiseptic, antipyretic and antizymotic.” It consists of one part of pure carbolic acid, two-hundredths of a part of corrosive chloride of mercury, and one-thousandth of a part of a mixture of alcohol and water, and manufactured by a process of “dynamisation and potentialisation that guarantees to the medical profession the absolute ac- curacy and uniformity” of the product (!!!). The enter- prising firm pushing this article has adopted the very MATERIA MEDICA, PHARMACY. THERAPEUTICS. 653 reprehensible custom, now all too common, of making use of the name of some well-known practitioner, who in the majority of cases, is totally averse to such pro- ceedings, to indirectly promote their end by quoting some article or isolated sentence of his to attract the at- tention of the hasty reader, whereas probably the author has not the remotest idea of even the existence of such a product. The loudly professed and much exalted liberty of our good land is, in more ways than one, now rapidly being extended to unwarranted license, and all without appar- ent check or redress. Resopyrin is occasionally heard of. M. Portes, some time ago, called attention to it as being the name given to the compound consisting of resorcin and antipyrin mixed in solution in proportion to their chemical equiva- lents. It occurs in colorless, oblique rhombic, prismatic crystals, soluble in alcohol and insoluble in water. Although it has been known for some years now, it has not met with very general use. Resorcin—one of the phenol derivatives—has not Only held the position attained for itself a year ago, but has steadily increased in favor by reason of the many excellent results which have been added to its list. It is accumulating much favor in the treatment of diarrhoea of children, and the various forms of gastritis. Pope recommends it in cases of gastric ulcer. Its analgesic property is so marked here that the stomach is enabled to tolerate food. He has also given it in cancer of the stomach with some advantage. Reports have been very favorable regarding its action in producing quiet sleep in general nervous excitability, and in the insomnia of typhus fever and pulmonary tuberculosis. In pruritus, apparently, the beneficial effect is quite marked in the majority of cases, and the relief lasts for SOme hours. Tymowski recently speaks highly of it, as he reports 654 NEW YORK STATE MEDICAL ASSOCIATION. having used it since 1884, applied locally to tuberculous and other ulcerations of the larynx, in diphtheria, ton- sillitis, pharyngitis, chronic rhinitis, etc. He uses solu- tions of increasing strength up to a supersaturated solution in cases where the ulcers are crateriform in shape and are foul at the base. The application is quite painless. Moncorvo, of Rio de Janeiro, again calls attention to his continued success in the treatment of pertussis, by applications of this agent, to the peri-laryngeal mu- cous membrane. By his method of application, which he gives in detail, as he claims the technique is impor- tant to secure favorable results, he affirms that he has established a perfect prophylaxis for children compelled to live with those who are suffering from the same affection, has aborted an attack at the outset in twenty- four hours, and has cured well-marked cases in from nine to fourteen days. Retinol (Resinol) — obtained by distillation of Bur- gundy pitch—still continues to be used quite largely as a solvent for many agents whose effects are enhanced by the antiseptic property it furnishes. Dr. E. Desnos, a French observer, is one of the most recent who reports gratifying results from solutions of Salol in Retinol—varying all the way from 5 to 10 per cent., used in certain cases of subacute cystitis. The peculiarity of this solution is that it will remain in the bladder, in diminishing quantity of course, after six or eight urinations. It has produced prompt relief in many obstinate cases where other agents were of no avail. Safrine is the fictitious name given to Safrol (to be alluded to next), imported into this country as artificial oil of Sassafras. Under such a name it has no medicinal uses, but when mixed with citronella or cassia oil and a small quantity of cedar-wood oil for preservative pur- poses, it is extensively used, in the proportion of One *Annales de la Policlinique de Paris for June, 1892, p. 265. MATERIA MEDICA, PHARMACY, THERAPEUTICS. 655 part to one thousand, by our household soap manufac- turerS. Safrol is the principal constituent of Sassafras oil— giving to it its characteristic odor. It is, however, now obtained in much larger quantities from camphor oil. This camphor oil is exported in large quantities from Japan, and is a waste by-product in the production of crude camphor. It is also exported to some extent from the Islands of Formosa and Borneo. The Chinese have used camphor oil for some time as a rubefacient in rheumatism, and possibly this fact alone led to the closer study of its constituents whereby safrol was isolated by Schimmel. Safrol has not by any means a general use, being little known in this country, but it has been used apparently with good effect in 1 to 2 cc. (16 to 32 minims) doses as an anodyne in subacute rheumatism. By far its largest use now, however, is in an industrial way—to disguise the odor of the fatty bases in soap making. Salicylamide was first prepared by Limpricht by treating oil of gaultheria with saturated ammonia water. It has since been made, but not preferably, from methyl Salicylate, the artificial oil of wintergreen. - Dr.W. R. Nesbitt, of Toronto, Canada, has now report- ed the results of his experiments with it, and has obtained it pure in the form of perfectly colorless, thin, trans- parent, plate-like crystals, moderately soluble in water. It is quite tasteless, and leaves a grittiness in the mouth. It is recommended as a substitute for salicylic acid, having the several advantages of tastelessness, of greater Solubility, of acting more promptly and in smaller doses, and of greater analgesic properties. The doses given were from 195 to 325 milligrammes (3 to 5 grains) several times a day. Clinical reports are yet Wanting. Salipyrin (Antipyrin Salicylate) is not yet obtainable in this country, and all that has been seen of it here has 656 JNETW YORK STATE MEDICAL ASSOCIATION. been brought over personally. There appears to be the same conflict which existed a year ago between the rival patentees of this and antipyrin, which prevents its free introduction here. From foreign reports of its use, it continues to have a varied career. Many claim that they obtain effects from its use in the different forms of rheumatism and in influ- enza which are more favorable than those obtained from either of its constituents; but as the fact of its being a very loose combination at best has been still further con- firmed, there would appear to be no good reason what- ever for not administering the antipyrin and the salicylic acid in conjunction, in proper doses to suit each individ- ual case, with decided advantage of cheapness in favor of this plan, as only about half the dose is necessary. From careful consideration also of the reported favorable re- sults, there would appear again no reason for not obtain- ing as good results after the administration of the two constituents in the proportion of about two parts of antipyrin to three of salicylic acid—to be varied some- what, according to indications in each case. It is to be hoped that some observers will be induced to report on such use of the constituents in comparison with salipyrin itself. Salol (Phenyl Salicylate), notwithstanding the many unfavorable reports and toxic effects noted from various sources, has made very substantial progress into a more favorable recognition than looked probable for it this time last year. It has been generally taken for granted on theoretical grounds that salicylic acid, when heated rapidly, is con- verted chiefly into carbonic and carbolic acids. Wierp and Ernert take exception to this, as they find by heating salicylic acid up from 160° to 240° C., excluding the air, it is converted into salol, water and CO3. Finding that they could produce salol in quantity quite equal to that indicated by theory, they patented the method. The toxic effects noticed at times may be met, accord- MATERIA MEDICA, PHARMACY, THERAPEUTICS. 657 ing to Dr. Chlapowski, by administering sodium sul- phate, or (if not at hand) any other sulphate. Drs. Lardier and Pernet recommend it in dysentery, and Dr. Weber says that it is superior to any other rem- edy in infantile diarrhoea. Dr. Mensi also confirms this use of it. Dr. S. Rush Ketcham, of Philadelphia, speaks of the dark staining of the children’s diapers, often noticed, as due to the carbolic acid developed after ad- ministering Salol. The very conflicting reports from its use in cholera have not by any means been so numerous as last year. Much more has been accomplished than heretofore, and yet there are a few observers who cannot yet understand how the reported favorable results are obtained. Dr. I. A. Mitropolsky speaks favorably of it in over fifty cases of cholera. Dr. W. Loewenthal is also a be- liever in it, and mentions that in the recent cholera epi- demic on the Phillipine Islands the results were surpris- ingly good, as Dr. F. J. Gonzales, of Salvador, claims to have treated fifty-three cases with but three deaths. Dr. Ph. Pégon reports good results from equal parts of a heated mixture of camphor and salol when used for suppurations of the middle ear. There is apparently no pain and no irritation set up. - Dr. E. Mansel Sympson, Surgeon to the Lincoln County Hospital, England, makes good use of salol in the treat- ment of chronic cystitis." It is much quicker in its action upon the urine than benzoate of ammonium, as in a day Or So, Ordinarily, the urine loses its foul odor and alka- linity and becomes clear. Gonorrhoea and genito-urinary troubles still continue to be benefited. Dr. B. Arnold, of Stuttgart, Germany, also reports much benefit from its use in any acute or chronic Catarrh of the bladder, and even goes so far as to Compare it favorably with any other agent used for a like purpose. 1 Practitioner, Vol. 48, p. 427. 42 658 METW YORK STATE MEDICAL ASSOCIATION. As theoretically salol is not dissolved in the alimentary canal until it reaches the pancreatic fluid, Dr. Le Ceppi has suggested its use as a pill-coating. To carry out this design, M. Yvon offers the formula: Salol, $ © g g tº e ſº tº o Gm 2. 0 Tannin, . o e & e e © © e 0.5 Ether, e tº g tº 10.0 The pills should be carefully varnished with this so- lution several times until a uniformly thick coating is obtained. Salophen (Acetyl-Para-Amido-Salol) is a new pat- ented synthetic product manufactured by the F. Bayer & Co. color works in Elberfeld, Germany. It is pre- pared at the start by mixing equal parts of para-nitro- phenol and salicylic acid. After a complicated process it is presented as a complete product in small, thin, laminar crystals, odorless, tasteless, and with a neutral reaction. It is practically insoluble in water. - The object intended to be attained in introducing this compound was to obtain an agent which would not pro- duce the unfavorable effects which have been thought to result from the elimination of carbolic acid when salol splits up in the intestines. The gastric juice has no ef- fect on salophen, but it is split up when it reaches the pancreatic fluid into salicylic acid and acetyl-para- amido-phenol, which latter passes on with little further change, and can be almost wholly accounted for in the faeces and urine. Up to very recently salophen has been used only in isolated cases by foreign observers in minimum doses of four to five grammes (60 to 75 grains) during a day— chiefly in acute rheumatism. Frohlich recently reports that in not one out of thirty cases of acute rheumatism did this remedy fail. Like the other salicylates he finds it cannot prevent relapses. He finds it can be given in large doses and for a long period without unfavorable effects. In chronic cases it is not nearly so efficacious. It has only very slight antipyretic action. MATERIA MEDICA, PHARMACY. THERAPEUTICS. 659 In our own country, Dr. W. H. Flint, of New York City, has made an interesting study of it in six hospital cases with very gratifying results." He “concludes that we possess in Salophen a remedy equally potent as the other salicylates to control the symptoms of acute rheu- matic arthritis, but devoid of their tendency to weaken the heart’s action, to disturb the stomach, and to pro- duce albuminuria and smoky urine. Whether these claims for Salophen to superiority over the other deriva- tives of Salicylic acid be well founded remains to be definitely decided by accumulated statistical evidence.” He finally expresses the “purpose to conduct a series of experiments as soon as suitable opportunities present themselves, with a view to ascertaining whether salo- phen may be made available for the purpose of securing intestinal antisepsis.” A more extended use is now looked for. “Sanitas.” Disinfecting Fluid (an unscientific trade name) has been more widely used during the past year as an external disinfectant and for surgical operations generally. It is an aqueous solution of turpentine, which has been oxidised by exposure to air. It contains some camphor in solution, thymol, hydrogen dioxide and a small pro- portion of camphoric acid. The proportion of the latter, however, is so small that it is hardly proper to claim, as some do, any special efficiency of the Fluid as due to this acid. The Fluid has many combined advantages. It is a good oxidising agent and antiseptic, is not poisonous, and does not soil clothing when poured upon it. Saprol (so-called “Disinfection Oil’’) is another new disinfectant recently brought out. It is a dark-brown, oily mixture, composed of the crude cresols in a great excess of the liquid hydrocarbons obtained from the re- fining of petroleum. This latter addition has the effect, 1 N. Y. Med. Jour., Wol. 56, p. 121. 660 NEW YORK STATE MEDIOAL ASSOCIATION. by thus reducing the specific gravity of the mixture, of rendering it so light that it will float as an oily film on water and give up its soluble parts as disinfecting agents to the offending fluid, leaving the remainder of the oily film floating on the surface to prevent the escape of dis- agreeable odors and the spreading of infecting spores. An unfortunate drawback to its more general use is its inflammability. Laser has looked into its properties, and finds that urine and faeces impregnated with micro-organisms like the bacilli of cholera and typhoid fever, can be effectu- ally sterilised by the application of about one per cent. of saprol. It is cheap and can be well and economically used on a large scale in barracks, prisons and Schools, provided care be taken about proximity to fire. Laser seems to have established the important point, of great ultimate practical utility, that sewage treated with it still retains its value as a manure. Sodium Tetraborate is the name which has been given to the comparatively new preparation obtained by the combination of equal parts of Sodium diborate (borax), boric acid and water. Heat is applied to com- plete the reaction, and upon cooling, the new Salt (?) is found to be neutral, thus apparently verifying the forma- tion of an entirely new compound. This salt (?) was introduced to furnish a more soluble form of boric acid, as it has been well known for some time that the solubility of boric acid was greatly in- creased by simply adding borax. It is at once recommended to be used wherever boric acid is applicable, and it has so been used ; but Menz finds upon investigation that it has the disadvantage of forming hard crusts on dressings, and that these irritate abraded surfaces. This compound may yet find a place for itself and claim more recognition than it has thus far received. Solutol is one of the newest disinfectants belonging to the same class as Creolin, Lysol and Saprol. MATERIA MEDICA, PHARMACY. THERAPEUTICS. 661 It was introduced with the idea of usefully disposing of the by-products in the manufacture of carbolic acid. The enterprising firm in Radebeul, near Dresden, which has held from the first Kolbe's patent for the manufac- ture of salicylic acid from carbolic acid, having reaped all the benefit they could from the patent, which has expired, now present this soluble form of cresylic acid (cresol). Cresol itself being insoluble, and therefore practically of little use as an effective disinfectant, Sodium cresylate was added to produce that result. Solutol is thus an alkaline solution of sodium cresylate in an excess of cresol. It is not suited therefore for surgical dressings or like uses on account of its caustic alkalinity. It is, however, of marked utility for very general and copious use in the household, hospital and morgue for effectually disinfect- ing water-closets, sinks, infected bed clothing, sputa and deleterious discharges of all kinds. It is especially effec- tive in the preservation of the cadaver. Solveol is another useful disinfectant analogous to Creolin, Lysol, Saprol and Solutol. It is another soluble form, like solutol, of cresylic acid (cresol), but is ren- dered so by the presence of sodium cresotate in place of Sodium cresylate. Its most striking qualification is its lack of that caus- ticity present in solutol. It is a dark-colored, nearly Odorless liquid, with a neutral reaction, and soluble in water in all proportions, even giving a clear solution in our ordinary hard waters. It possesses a great advantage over creolin and lysol in not exhibiting that greasiness so noticeable in these two. In contradistinction to solutol it is especially appli- Cable to surgical uses—a one-half per cent. Solution being used in surgical dressings and a one to twelve for the Spray apparatus. It is claimed that its antiseptic prop- erties are far superior to those of carbolic acid, a half per cent. Solution being more active than a two per cent. Solution of carbolic acid. 662 NEW YORK STATE MEDICAL ASSOOIATION. Somnal, the liquid hypnotic (made by the union of chloral, alcohol and urethane) which was beginning to receive a decided recognition from those who were not expecting too much from it, has come to stay. Its drawback, if it may be called such, has been, and will continue to be its failure to be a general hypnotic, applicable in all cases of insomnia, and those who expect this of it will be repeatedly disappointed; but if all will admit its applicability to certain classes of cases, favor- able results may reasonably be expected in such cases in almost every instance. Dr. O. M. Myers, of Rochester, N. Y., has recently made a careful and interesting experimental and clinical study' of its physiological and therapeutic action, and gives a summary which may very fairly be taken as the present standing of Somnal: “Its sedative and somnifer- ent action is strikingly efficacious in the insomnia occur- ring during convalescence from acute disease. Where an adynamic condition exists, it must of course be used with caution. In whooping-cough, Spasmodic laryngitis, asthma, “nervous cough,” and chorea, it possesses de- cided sedative properties. A great element of safety is that the action of somnal, so far as I have observed, is never out of proportion to the amount ingested, nor does it act in a cumulative or other unexpected manner. The drug appears to possess little or no influence over insom- nia due to acute inflammatory conditions.” Sozal is the name applied to another very recent anti- septic. It is the aluminum salt of para-phenyl-sulphonic acid (sozonic acid), which latter is made from carbolic and sulphuric acids, as described under the head of Sozo-Todol. It is very soluble in water and keeps well. It occurs in crystals with an astringent taste and slight carbolic acid odor. It is recommended for surgical dressings. It is a rather weak antiseptic, and more experience and trials are needed before it can come into more general use. 1 N. Y. Med. Record, Wol. 41, p. 286. MATERIA MEDICA, PHARMACY. THERAPEUTICS. 663 Practically nothing has been heard of it in this coun- try, and very little of it in the old country as yet. Sozo-lodol (Di-Todo-Para-Phenyl-Sulphonic Acid) is another of the already numerous German antiseptics, now patented in this country, but which has been far less known here than abroad, where it has been used for about six years. An outline of the production of this agent may be of sufficient interest to mention here : About two parts of crude carbolic acid (phenol) are added very slowly to one part of strong sulphuric acid. The reaction raises the temperature to about 110°C. and continues for two or three days, when para-phenyl-sulphonic acid (SOZonic acid) is formed. Any excess of carbolic acid is removed, and then iodine is added to form this Sozo-iodolic acid (sozo-iodol). It contains about 54 per cent. of iodine, 20 per cent. of carbolic acid and 7 per cent of sulphur. The ammonium, lead, mercury, potassium, Sodium and zinc salts of this acid are the agents mostly employed, being recommended as substitutes for iodoform on account of their complete lack of odor. The sodium salt, however, is the one most favored so far, and is seen in bright needle-like crystals, somewhat prismatic in form. A five to ten per cent. solution of this salt in water is found to be about the most suitable limit. Sozo-iodol and sozo-iodolates have been used in almost every affection for which iodoform is applicable. In fine powder it has been effectively used insufflated into the nasal cavity and the larynx. Dr. K. Witthauer has recently employed the mercury Salt, as an emulsion, an insuftlating powder, and an Ointment, with apparently good effect. Nothing much has been heard from our own practi- tioners as yet. Spermin still claims attention from a few enthu- siastic neurologists, but it has gained no place in the estimation of conservative and rational observers. 664 NEW YORK STATE MEDICAL ASSOCIATION. Styracol—the cinnamic ether of guaiacol—has made no progress since last year, and little has been heard of it either as an external antiseptic, in internal use in pul- monary tuberculosis or in chronic catarrhs of the bladder, stomach and intestines, from all of which something was confidently expected by this time if expectations were to be realised. Sulphaldehyde –the new hypnotic of last year (obtained by the action of sulphuretted hydrogen on ethylic aldehyde)—has been little heard of either in this country or abroad during the past year, and unless it is being tried privately without reporting results, it may practically be classed as dead. - Sulphaminol (Thio-Oxy-Di-Phenyl-Amine) is a new German antiseptic, introduced last year to replace iodo- form on account of its lack of any odor. It is obtained by the reaction between the salts of meth-oxy-di-phenyl- amine and sulphur, and is seen as a light yellow powder insoluble in water, and without taste or odor. Theoreti- cally it is supposed to be decomposed into carbolic acid and sulphur compounds by the digestive fluids. - It acts after a fashion in checking suppuration in some cases, and this may be said to be its chief claim, if any, to recognition. It has been insufflated into wounds and into the nasal fossae and sinuses of that region with some reported beneficial effect. A Polish practitioner, Wojtaszek, has now carried out experiments on rabbits to test the claims of the intro- ducer, and he finally “concludes that sulphaminol is devoid of any physiological action. As regards its alleged antiseptic properties, they also seem to be about 77,77.” Very few reports have been made upon its use during the past year. Sulphonal (Di-Ethyl-Sulphon-Di-Methyl-Methane)— produced by the oxidation of a mixture of ethyl-mercap- tan and acetone—has been widely extending its sphere MATERIA MEDICA, PHARMACY. THERAPEUTICS. 665 Of usefulness during the past year, and has lost few of its enthusiastic advocates. Particularly gratifying results are noticed after its employment in mental diseases of pretty much all classes. The insane asylums throughout the world are now large users of it, and pretty generally give favorable testimony. It appears to be of special value in acute melancholia and insanity. There are a few who claim, on the other hand, that at times it exhibits a decided cumulative action. It is folly to claim, as some feel disposed to do, that it is void of disagreeable results. One can hardly fail noticing untoward effects, especially in cases where much physical prostration is present. It has been stated that it is looked upon with such suspicion in Turkey that it has been interdicted throughout the Empire by Imperial decree. Surely caution should still be studiously observed in its use, and the more so as its more frequent employ- ment would tend naturally to render us quite oblivious to its drawbacks and peculiarities. Fatal cases are still being reported, but they are not by any means in pro- portion to the increased number of successful ones. As a striking contrast to this, Dr. Ernst Neisser reports that a fifteen-year-old boy took 100 grammes (34 ounces) of the fine powder at one dose with a copious supply of water to wash it down. He slept continuously for five days, but did not assume full consciousness un- til the seventh. On the ninth day he left the hospital in apparent good health. This case naturally should not be taken as a precedent. Dr. S. Grover Burnett, of Kansas City, Mo., has made, and is still making quite a systematic study of its pres- ent sphere of usefulness, and is continually looking for new fields for it to occupy. He reports the results of his Observations on four cases studied particularly to ascer- tain the hypothesis to work upon in accounting for the loss of reflex after large or continued doses. His obser- 666 NEW YORK STATE MEDICAL ASSOCIATION. vations deserve reading by those who are at all interested in this line of research." Finally, the majority of the conclusions reported up to this time are that, although by no means a perfect hypnotic, sulphonal takes a very important place in the treatment of sleeplessness and restlessness generally. Sulphune (so-called “Pure Liquid Sulphur.”) is a preparation introduced by a Western firm as a “cure- all” for “diphtheria, ulcerated throats, open sores and ulcers, skin diseases, rheumatism and other affections,” which proves to be little else than an aqueous solution of some of the higher sulphides of sodium and potassium saturated with sulphur. Sulphides of calcium and mag- nesium are present in small amounts, probably as im- purities. . The great imposition upon the public, however, is the charge of $1.00 for a half-ounce vial of the product in a pasteboard case with printed explanations, when the whole get up of the thing should bring in a handsome profit at a selling price of 25 cents. It has not been as yet fully “sprung” on us here in the East. Terebene is produced by the action of strong sul- phuric acid upon oil of turpentine and repeated distil- lation to purify it. The latter part of the process has in many cases proved tedious, and therefore ineffectual by reason of the manufacturer's anxiety for too speedy results. - It is far from being simple in composition, for it con- sists of camphene, cymene, borneol and terpilene. It is a light yellow liquid with the pleasant odor of newly-cut pine wood. It is practically insoluble in water, but may be emulsified. It has been used for years as a very decided and agreeable antiseptic, disinfectant and deo- doriser, and has lost nothing thus far in usefulness. A five per cent. solution makes a very serviceable surgical 1 N. Y. Medical Journal, Wol. 55, p. 406. MATERIA MEDICA, PHARMACY. THERAPEUTICS. 667 dressing, and its vapor, inhaled directly or through an atomiser, acts well in bronchial affections and even in pulmonary tuberculosis. Thilanin is the name given by Seibel to a sulphuret- ted lanolin—a new product. It is produced by allowing sulphur to act on lanolin, and contains three per cent. of sulphur. It is a yellowish-brown substance of very much the appearance of Vaseline. It is devoid of irritating properties, and has been beneficially used by the dermatologists in most forms of eczema, in acne, and in the many affections usually treated by ichthyol and thiol, which latter it is designed to replace. More extended use is necessary before very decided opinions can be expressed. Thiol-the German artificial ichthyol—has now been in use somewhat over two years, and has made some progress in its favorable results during the past year. It is still used in the two forms of purer powder or scales, and in the less pure liquid. The latter is about one- third the cheaper because not purified, and therefore is much oftener used. The liquid form is, again, much cheaper than the natural ichthyol. The gynaecologists have now come to be about the largest users of the article, although the dermatologists are not far behind them. The reports in its favor still continue to be that it causes no pain, burning or other irritation, does not cause bleeding from eroded parts, promotes rapid absorption of effusions, and has advan- tages over the natural ichthyol, besides being painless and almost without odor, and that the stains produced on linen are easily removed. Thiophene is a hydrocarbon first pointed out by Victor Meyer as occurring in all commercial benzenes (from coal-tar). It is isolated from these by active agita- tion with about one-tenth of the volume of concentrated Sulphuric acid. Thiophene itself has been little used therapeutically, but its compounds, both lead and sodium thiophene- 668 NEW YORK STATE MEDICAL ASSOCIATION. sulphonate and thiophene di-iodide, have been reported on favorably by Dr. Edward Spiegler in Professor Kapose's clinic in Vienna. The above lead and sodium salts are of service in all forms of prurigo made up into the form of ointments. Little irritation is produced, and the lead salt acts slower than the sodium. The thiophene di-iodide, occurring in small crystalline plates insoluble in water, has been well used as a sub- stitute for iodoform, and Dr. August Hock, of Vienna, speaks well of its use clinically in the powder form in all wound dressings, where it seems to retard the formation of pus and to prevent exuberant granulations. It is also of much service when applied by means of a gauze con- taining ten per cent. The odor of such a gauze is not only agreeable, but it acts as a deodoriser to suppurating wounds, compound fractures, mastitis and caries of bone, and in this it is far superior to iodoform. Eczema complicating prurigo is better treated with this iodide than with naphthol. Surgeons here have paid compar- atively little attention to it, but no doubt more will be heard of it later. Thymacetin is a new analgesic remedy introduced by Hoffmann, of Leipzig. It bears the same relation to thymol that phenacetin does to phenol, and is a white Crystalline powder, sparingly soluble in water. Only a small quantity has as yet been available for physiological tests, and therefore the reports are quite limited, and little is known definitely of its action. Dr. F. Jolly, of Berlin, however, read a paper recently giv- ing his results after administering it to both the lower animals and man. No definite results have yet been obtained as to its antipyretic properties, but as an anal- gesic and hypnotic it has shown something favorable. In seven cases of migraine it had no beneficial effect, al- though in other forms of headache it gave as good results as phenacetin. In twenty-six cases of paralysis and de- lirium with insomnia it produced quiet sleep in sixteen, and had no effect in ten. The average dose required to MATERIA MEDICA, PHARMACY. THERAPE UTICS. 669 produce the sleep was 500 milligrammes (7% grains). The secondary effects noticed, were acceleration of the pulse and a complaint of fullness, beating and noises in the head. Surely further trial is needed before any very definite conclusions can be drawn as to its usefulness or fitness for recognition among the great number of like remedies. Trional ſº g and are two comparatively new hypnotics Tetronal allied to sulphonal, which have been more or less on trial for somewhat over three years. They are yet far from widely known, and very little is reported on them in this country. They are produced by processes which are too techni- cal to be reproduced here, but it may suffice to mention that in 1889 Dr. T. Lauder Brunton reported on his in- vestigations on the relation of chemical constitution to physiological action, and thus led up to other investiga- tions in this line. Among these was a report on the physiological action of the disulphones, to which group sulphonal and these two belong. It was found that only those compounds containing ethyl groups were physio- logically active, and the hypnotic activity increased with the number of such groups. In Sulphonal there are only two ethyl groups; in trional there are three, and in tetronal there are four, as the etymology of the latter two names indicate, and the hypnotic effect was found to increase just in that proportion, tetronal requiring Only half the quantity to produce the same effect as sul- phonal. Dr. Ernst Schultze, of Bonn, Schaefer, of Jena, and the Italian A. Ramoni, have all reported favorably and at length on the use of both these newer agents in series of cases. Both agents are found to be superior to sul- Phonal and chloral in being more prompt and vigorous, in that the patient awakes more easily and generally no unpleasant after-effects like nausea, vomiting and loss 670 JNEW YORK STATE MEDICAL ASSOCIATION. of appetite follow, although occasionally there is slight digestive disturbance, and in that the action is more rapid. They both have a marked hypnotic and sedative effect, but tetronal has more sedative action. Trional acts more surely and promptly in the sleeplessness accompanying the different forms of neurasthenia and organic brain affections, and the sleep is more lasting and sound. Therefore, it may be classed by some as superior to tetronal, although it has less of the hypnotic ethyl group in its composition. However, the sleep from either lasts about six to eight hours, and is not generally interrupted by dreams. No effect is produced in sleep- lessness due to pain, and no untoward symptoms follow the discontinuance of either. Tuberculin (Parataloid) has had very considerable attention paid to it in a much more quiet way during this past year. The disappointed ones have dropped it completely, and only those who love this kind of re- search have pushed on with Professor Koch himself to perfect it if possible. In October last Professor Koch published his third communication on the subject, dealing chiefly with his chemical results, but he also gave at last the long waited for and promised method of preparation. After reading it carefully, it is very evident to all bacteriologists that there was little need for having kept the process secret so long, as his method of procedure had been known and practiced by others before him, and although he must have realised this fact if he did any current reading on his subject at all, he gives the recognised investigators no credit whatever, but rather takes all workers to task for not accomplishing the results he would expect from them. Dr. W. Hunter is one of those who has made probably the greatest step in advance in the preparation of the fluid, but whose work, however, has been wholly ignored by Koch. Dr. Hunter published his observations last year, and now sufficient time has elapsed to see the im- MATFRIA MEDICA, PHARMACY. THERAPEUTICS. 671 provement in clinical results obtained from experimen- tation with his “A,” “B” and “C” modifications. It may be well to repeat here that “modification A ’’ is the albumose precipitate thrown down from tuberculin by the addition of ten times its bulk of alcohol. The alcoholic filtrate left is the “modification C.” “Modifi- cation B” is the solution obtained after isolating all the salts from “modification C'' by precipitation with am- monium sulphate and dialysis. Numerous experiments upon cattle have been con- tinued both in France and England with directly opposed results. Hospitals, dispensaries, and a few individual physi- cians have experimented with the agent with very diverse conclusions. The Hospital for Consumption and Dis- eases of the Chest, at Brompton, England, reports its results in cases of pulmonary tuberculosis and lupus. It was used systematically for four months, during which time thirty patients were treated with it, and the conclusions reached were : “That the tuberculin did not favorably influence the course of the disease in the majority of cases; that in some the effects were detri- mental; and that even in the stationary and improved cases it was difficult to ascribe any distinct improve- ment to the injections which might not have been equally attained under the treatment ordinarily employed in the hospital.” It is reported that its further use in the military hos- pitals of Russia has been absolutely forbidden on account of both negative and injurious effects produced. On the other hand, Dr. J. W. Springthorpe, of Mel- bourne, Australia, publishes a second report of his experience during three months with the use of Hunter’s modification and with the ordinary fluid for more than nine months, and concludes that “it seems probable that the end will be, not the abandonment of the lymph, but the elaboration of different modifications, each with a Wide though somewhat different sphere of usefulness, and 672 NEW YORK STATE MEDICAL ASSOCIATION. each, when properly used, operative and valuable beyond all precedent in the treatment of tubercular disease.” In our own country many prominent observers have not only abandoned its use, but positively discounte- nance its employment in any case. Dr. Francis P. Kinnicutt, of New York City, however, pushed his investigations in nineteen cases of pulmonary tuberculosis treated in St. Luke's Hospital during last winter with Hunter’s modifications. He concludes by stating in substance that, although the number of cases treated were very much too small to justly express a posi- tive opinion in regard to its being a specific, still they were sufficient to indicate the decided desirability of con- tinuing investigations into its apparently specifically beneficial effects. Tuberculocidin (Alexin) is the name given by Dr. E. Klebs, of Zurich, to his new preparation of tuberculin obtained by treating the crude tuberculin with platinum chloride. By such treatment the alkaloidal bodies are precipitated, leaving a solution which differs from the original by that much abstraction at least, and this elon- gated name is given by Klebs On account of its supposed antagonism to the tubercle bacilli itself, resulting in its degeneration. This new derivative itself may be thrown down from the solution as a precipitate by the addition of alcohol, but it is usually retained in the form of solu- tion for ready use. Detter results have been obtained now in many ways and by several observers from this modification than from the tuberculin of Koch. Klebs claims from his experiments upon animals that he has observed complete regression of an apparently advanced tuberculosis, and the sooner employed the better the result. He reports on the treatment in man of seventy-five cases upon which he feels ready to give his conclusions: Fourteen may be classed as cured, forty-five as improved, fourteen unim- proved ; and two died. The severest cases were among the unimproved. MATERIA MEDICA, PHARMACY. THERAPEUTICS. 673 These results are surely very encouraging, but after the many failures already on record, observers will Con- tinue to be sceptical as to the claim of tuberculin Or any derivative being completely curative. * Tumenol is another comparatively new compound closely allied to ichthyol. It is obtained by treating the unsaturated hydrocarbons of mineral oils with concen- trated sulphuric acid. There are several compounds formed by a more or less extended treatment, not of moment here, known as “Commercial Tumenol,” “Tu- menol-Sulphone” (Tumenol Oil) and “Tumenol-Sulpho- nic Acid,” varying somewhat in their physical proper- ties, and therefore applicable to somewhat different cases. The first is a dark-brown almost black fluid, the second is a thick, dark-yellow, syrupy fluid with a bitter taste, and insoluble in water, and the third is a dark Odorless powder, with a peculiar slightly bitter taste and readily soluble in water. One is reminded strongly of ichthyol by these preparations, and yet the former con- tains, from the nature of the products used in its prepara- tion, much more sulphur than these latter compounds. Prof. A. Neisser, of Breslau, now reports to the Ger- man Dermatological Society his results with these com- pounds for the past two years. The “Commercial Tumenol” was in general found to be most efficacious and somewhat the cheapest form. Aside from a most generally used ointment excipient, the tincture was most Serviceable. He finds that unlike ichthyol, which de- pends for its action on the sulphur in its composition, the tumenols rather owe their therapeutic action to their powerful reducing properties. Their action appears to be chiefly superficial. Almost universal success follows its use in all forms of pruritus—particularly when the tincture is used. Moist eczemata are specially benefited, and good results are generally obtained when used in erosions of all kinds, excoriations and superficial ulcerations. Although it may act well in some deep ulcerations, still it does not 43 674 NEW YORK STATE MEDICAL ASSOCIATION. possess this property as markedly as ichthyol. Neither is it at all anti-parasitic in its action. It is not at all of service in erysipelas, which ichthyol, or better thiol, is. Little has been reported concerning it in this country as yet. - Urethan (Ethyl Carbamate), which was brought into prominent notice about the middle of the year 1885 by the interesting and extended researches of Dr. O. Schmiedeberg, Professor of Pharmacology in the Uni- versity of Strassburg, “On the Pharmacological Action and Therapeutic Application of some Ethereal Salts of Carbamic Acid,” we hope may still be of sufficient interest to recall here an outline of its preparation. Commercial ethyl chloro-carbonate is treated with ammonia water, shaking the liquid, after neutralisation, with ether, wash- ing the ethereal extracted portion with water and distill- ing off the ether, when the ethyl carbamate is left in the flask—to be finally dried over sulphuric acid. Since last year, it has been reported from some quar- ters that this agent is “practically dead now.” This is unfortunate if true, but can hardly be true. It is a mild hypnotic at best, and therefore possibly more may be expected from it than justly should be. There are now so many not only very active and prompt, but powerful and treacherous hypnotics in use, that this mild, moder- ate, and safe one is possibly put into the background to allow its more robust and vigorous rivals to occupy the field, widely extended by remunerative advertising and the too prevalent desire for novelty. Urethan is such a safe and effective hypnotic to give children that it would be undesirable, to say the least, to retire it completely. Weights and Measures by the Decimal (Metric) System are in decidedly better favor now than at this time last year. Much attention has been given to the subject not only by individuals, but by societies—both medical and pharmaceutical—to further its progreSS. Scientific workers in all branches are presenting the MATERIA MEDICA, PHARMACY, THERAPEUTICS. 675 subject to the public in all possible aspects to render a trial use of it more inviting and easier of accomplish- ment. The English are pushing the matter vigorously, and in no more marked way than by their “New Decimal Association (Established to promote the adoption of the Decimal System of Weights, Measures and Coinage in the United Kingdom).” They have a long list of their prominent countrymen in their association in full Sym- pathy with the work. They are wide awake to the stern fact that their foreign trade and interests will insidiously slip away from them if they do not join the fast increas- ing number of those who have adopted this system per- manently; and the United States are in the very same predicament, with possibly the slight advantage in their favor of having a coinage well fixed in that system already. China is one of the latest nations about to See the wisdom shown by their neighbors in Japan by throw- ing over the old English system. “The countries which have now already adopted this system represent a popu- lation of 420,000,000.” It has been pointed out by some objectors that there are so many new terms to be learned that it is confusing, but it should be recollected that about two-thirds of the names usually given in the complete decimal tables are Seldom used, even in France, and are surely not needed in general use. In Germany only nine names are learned and used for general every-day use. The Revision Committee of the United States Pharma- Copoeia are about completing their work, and physicians and pharmacists should surely be ready for the approach- ing edition with a reasonably clear knowledge of the System to be used there exclusively. DERMIC AND HYPODERMIC THERAPEUTICS. By S. F. RogFRs, M. D., of Rensselaer County. (Read by title November 17, 1892.) [ABSTRACT.] It is our purpose in this paper to consider the skin as a medium for introducing medicines into the system. A study of the anatomy and physiology of the skin, and its relations to the underlying tissues, shows why our fore- fathers in medicine looked upon it as a desirable avenue for the entrance of their medicaments. The skin not only serves as a protection for the deeper tissues, but is an important organ of excretion and absorption. Its anatomical structure shows clearly that it is one of the four exits of water from the body. On theoretical grounds there is every reason to believe that the internal organs can be reached by medicines absorbed through the skin, and there is abundant clinical evidence to establish this theory as a fact. How often have we all seen the constitutional effect of mercury produced by its application to the skin as an ointment ; and how often, too, has cod-liver oil proved a boon to humanity, and bridged over a critical period, by supplying through the skin the nutriment which could be obtained in no other way ? I have found it the most readily assimilated of all fats, and for our present purpose, the therapeutic agent par eaccellence. In cases of typhoid fever in which the administration by the mouth of the mildest cathartic might give rise to alarming symptoms, I have found that the dermal method of administering castor-oil has often given fair results. But it is not my purpose to enumerate all the remedies which may gain entrance into the system DERMIC A. WD BIYPODERMIO THERAPEUTICS. 677 through the skin ; I desire rather to insist on the methods of administration. Local diseases and injuries have always been treated largely by local applications, and their use by the regular profession has furnished an avenue for the entrance of quackery into nearly every household. In enteritis, peritonitis and pneumonitis, I never think of doing without local treatment; and, indeed, the people have come to look upon the poultice as an almost indispen- sable part of the treatment of pneumonia. Turning now to the subcutaneous cellular tissue, we find that absorption through this channel is ordinarily very rapid. It may be retarded experimentally * by section or galvanisation of the sympathetic. But aside from the influence of the nervous system, it is to be remembered that the rate of absorption is in direct proportion to the solubility of the substance. The local action of some remedies induces inflammation, and so interferes with absorption ; and, again, Some substances prevent absorption by coagulating the albumen of the tissues. This latter action is sometimes sought for, as for example, in malignant pustule when we endeavor to limit the formation of pus by peripheral injections of iodine. The hypodermatic injection of water as a substitute for morphine has found some followers in the profession, and Dr. Pollak actually quotes a case of Sciatica cured by the injection of ice-water. 1 Claude Bernard, 1872, pp. 285–287. SOME RECENT EXPERIENCE IN RENAL - SURGERY. By E. D. FERGUSON, M. D., of Rensselaer County. November 17, 1892. Statistics may or may not have value. Reports of in- dividual experience may or may not possess interest. Still we are in a measure dependent upon numerical con- siderations in our estimate of the probabilities of the effects of certain procedures. This mathematical method cannot be vigorously applied to move or stay our hands in surgical intervention, but it seems fairly applicable in those cases in which general considerations would indi- cate a notable hazard from interference—to those classes of cases in which our average shortening of life may equal or eacceed any increase we may induce. This may be applied particularly to the class of cases of which I am about to give examples, for renal surgery has not entirely passed its tentative period, the details certainly being debatable. Recognizing the not unnatural tendency, which has developed from safer surgical technique, to cut our way through a tangle of morbid processes, it is manifestly the part of wisdom occasionally to put the question, cut bono, and seek the answer in an estimate of the probable ultimate results rather than in the simple issue of life or death as immediately related to our operative measures. Some of our bold and brilliant operations might not stand the test of such a tape-line, particularly in the domain of malignant diseases of internal Organs, and in that more recently assaulted portion of the human anatomy—the brain. RECENT EXPERIENCE IN RENAL SURGERY. 6.79 The cases I have to report present features and acci- dents that impressed me as possessing sufficient interest to warrant my putting them on record. The first case:—A woman, aged about 40, consulted me the last of May, 1891. She had been residing in the city of New York, and her trouble had been variously diagnosticated as consumption, malaria, uterine disease, etc. She was greatly emaciated, had irregular chills and some fever, evidently of a septic origin, but the presence of a large amount of pus in the urine without corre- sponding vesical symptoms, and a moderately movable but enlarged and tender right kidney, taken in connec- tion with a negative result from examination of the other organs, rendered the diagnosis sufficiently com- plete to justify interference. She was sent to her former home in Plattsburgh, it being the most satisfactory place to her for the rather prolonged confinement to her room and bed likely to follow operative work, and on June 23, 1891, I operated. The delay was due to her inability to at Once accept an operation, and the attendant preparations. The lumbar incision was, of course, selected, and the kidney was found largely distended with pus, in fact, it was practically converted into a cyst, the amount of pus being estimated at from twelve to sixteen ounces, but the kidney had not been fixed by peri-renal inflamma- tion. The incision into the kidney was amply sufficient to allow of a thorough exploration by means of the finger and probe, and no calculus was found. The absence of condensation of the peri-renal tissues would have rendered the removal of the Organ a com- paratively easy matter, but the profoundly weakened condition of the patient would have rendered this major proceeding quite hazardous at the time of the Operation ; but the decision was in a measure influenced by the fact that a quite common conclusion seemed to have been reached that it was safer and better to do a secondary 680 NEW YORK STATE MEDICAL ASSOCIATION. operation for nephrectomy rather than to remove the Organ as a primary Operation, and so the kidney was allowed to remain. Drainage by rubber tubes was pro- vided, and the patient remained under the care of Dr. E. M. Lyon, of Plattsburgh. Her fever subsided promptly, irrigation was regularly practiced, her appetite returned, slowly a fair degree of strength returned, her urine was nearly free from pus, and she was in every way apparently progressing favorably. In December she came to Troy to be under my care, and soon after I found some phosphatic deposits, apparently in the pel- vis of the kidney—or the deeper portions of the sinus, but from the fact that they were of a scale form led me to hope that the deposit was limited, and that with irri- gation, probe, spoon, and forceps I might get rid of them. After a few weeks, failing to find any more, I hoped that I had been successful. During February, 1892, she contracted the prevailing influenza, and suffered from a violent and persistent cough, which after a few days seemed to develop some mischief in the right renal region, for pain returned with tenderness, and after a short time it was evident that cellular inflammation was extending deeply in the direc- tion of the psoas muscle toward the brim of the pelvis. While unable to determine with certainty the method of development of this complication, I was inclined to attribute it to separation or tearing at the cortical portion of the kidney where the sinus wall was attached, allow- ing thus infection in the peri-renal tissues. The extreme violence of the cough would render this plausible. The fever associated with this new focus of inflammation, to- gether with the bronchial trouble, made profound inroads on her strength and rendered any serious operative meas- ure extremely hazardous; but as she was now manifestly sinking rapidly, she wished the chance that might come from opening up the new focus of suppuration, and the removal of the kidney if thought best. The progress of the Suppuration downward had been such as to compress RECENT EXPERIENCE IN REWAL SURGERY 681 the colon by means of inflammatory exudation and puru- lent collection, so that severe attacks of colic became frequent, and were evidently associated with the move- ment of the intestinal contents in the region of the Caput coli. The involvement of that portion of the bowel was anticipated from the local condition and the symptoms, and the expectation was confirmed a day or two before the operation by the appearance of a faecal odor in the pus discharging from the sinus—for this pocket opened into the sinus, but could not be entered for purpose of drain- age. On April 21st the operation was done. The outlook was very unpromising, for she had again become ex- tremely emaciated, and her pulse rate was from 130 to 140. On opening down to the locality of the disease, it was found that the pus pocket had extended to the brim of the pelvis and communicated with the colon, as shown by seeing and hearing the escape of intestinal gas, as well as the olfactory evidence. In order to afford any chance for recovery, it seemed necessary to remove all sources of a continuation of the inflammation, and to do this I decided to remove the kidney. I can readily understand why operators have been obliged to stop the operation without completing the nephrectomy—all anatomical landmarks are gone, the finding and isolating the kid- ney, or what remains of it, from the surrounding dense inflammatory exudate is a trying procedure, which can- not be accomplished by any preconceived plan, but must be managed as seems best in the individual case. After a time the kidney was isolated and removed. The haem- Orrhage from the pedicle was not profuse, but it required Several ligatures before it was controlled, and then to make it more probably secure, the actual cautery was applied; the wound was packed with iodoform gauze and the patient put to bed, in quite a profound degree of Shock, and external warmth applied. In the course of the removal of the kidney several phosphatic concretions were found, but most of them Were lost in the irrigations; but in the shrunken kidney 682 NEW YORK STATE MEDICAL ASSOCIATION. which I show can be felt in one calyx a collection of such concretions, which illustrates how readily they may be overlooked, for I did not discover them until I had examined it several times. I also show one of a nest of calculi and a fragment of a larger concretion. The future history of the case is what renders it particularly interesting to me. I had met anuria following renal and other operations several times, and it was antici- pated as probable in this case. The shock gradually passed off, and the time came for an investigation rela- tive to the secretion of urine, but none was found. Twenty-four hours passed, no urine; the prognosis very grave. Thirty-six hours—no urine, the breath of a urin- ous odor, mental faculties becoming sluggish. Forty hours—still no urine, a notable stupor, the prognosis unqualifiedly unfavorable, for I had never seen the func- tion reëstablished after suspension for such a length of time in a surgical case; but at about forty-four to forty- six hours a little urine came ; it rapidly increased, and in a day or two from three to five pints were secreted daily. Though for a few days her life seemed in an equipoised balance, improvement finally was manifest, there was a complete subsidence of fever, the pulse fell to about 90, and the ligatures came away on the ninth day. The granulation process proceeded so rapidly that at the end of two weeks the deep portions of the wound had so filled as nearly to obliterate the pocket at the side of the colon, the site of the ligatures was covered in, the general functions were well performed, and she was in every way comfortable on May 13th, the twenty-third day after the operation. The wound had so far filled in with new tissue that I proposed to begin the process of strapping it on the following day, when a telephone message late at night brought me the unexpected intel- ligence that she had died within a few minutes from secondary haemorrhage from the renal artery—an event which I had feared in the early stages of the case, but had come to regard as quite improbable. RECENT EXPERIENCE IN RENAL SURGERY. 683 The second case was the wife of a physician, and her first trouble resulted from a fall several years before I saw her, when there was an injury from a nail to the tissues adjoining the urethra. An irritable urethra re- mained. During the winter of 1890–91 I first took charge, and found her suffering from a probable pyelitis of the left kidney. There was a free amount of pus in the urine, considerable renal pain, and notable constitu- tional symptoms. With rest in bed and the free use of water the pus disappeared nearly entirely from the urine, and her general health became good, but as the urethra was sacculated and very sensitive just within the meatus, I finally did a “button-hole” operation on it in the summer of 1891, and with a few careful appli- cations of nitric acid to the hypertrophied tissue lining the anterior urethra through the button-hole opening, she became quite comfortable and gained in flesh and strength So as to consider herself as nearly recovered. Sud- denly this favorable progress was interrupted by a recur- rence of the pyelitis, and after a few weeks a tumor could be felt in the left renal region. The constitutional symp- toms were marked, the fever was high, the emaciation rapid, so that about Christmas, 1891, I did a nephrotomy Opening through quite normal renal tissue, but evacuat- ing several ounces of pus. An exploration of the interior of the kidney by the finger and the full use of the probe failed to discover a calculus. With the exception of Some trouble from the drainage tube, it being more diffi- cult to maintain drainage where the kidney has not been notably thinned by a large distention, she progressed very satisfactorily, and was soon free from fever and pain, had a return of appetite, and gained flesh so as to be quite plump in her figure, while her color acquired a healthy appearance. During March, however, pain in the kidney returned, and though drainage was well maintained, it was appar- ent that new mischief was present in the kidney; the fever and chills, the rapid emaciation and the severe pain 684. JNETW YORK STATE MEDICAL ASSOCIATION. in the left renal region, while a free secretion of urine by the bladder and the sinus still continued, led to the con- clusion that disseminated foci of suppuration existed in the kidney. The diminution of her strength was so rapid that a fatal issue was apparently not very remote, and she, realising fully the nature of the case, practically re- quested the removal of the kidney. I neglected to state that at the nephrotomy there had been a suppression of urine for something over twelve hours after the opera- tion, so that at the nephrectomy, after fully considering the immediate and the remote risks, it was decided to use chloroform. The operation was arranged for April 22, 1892, and just after I had made the incision through the skin, the heart ceased to beat, and another case was added to the list of those dying from cardiac syncope under chloroform. After diligent efforts at resuscitation had been made and it was apparent that life was extinct, with the consent of her husband, I completed the incis- ion and soon recognised what would have been a very troublesome complication in completing the operation, viz., a horseshoe kidney. While it is possible that the diseased element of the compound organ might have been removed by ligature of the connecting band, it is not probable, in view of the continuity of renal tissue through the connecting portion, that the patient could have Sur- wived more than a few days. The last case carries the lesson that very profound sys- temic effects may be induced by moderate changes in the renal structure; for, as will be seen by the specimen, but little change had been produced; there was a moderate pyelitis and a few small collections of pus in the renal substance, none larger than a small bean. In both these cases the pus contained in the urine had been examined for tubercle bacilli with negative results, and the foci of suppuration in the horseshoe kidney Were also examined with the same result. The apparent preference for a nephrectomy secondary to a nephrotomy seems to me a doubtful surgical canon RECENT EXPERIENCE IN REWA I, SURGERY. 685. to apply in all cases. In the case of the horsehoe kid- ney, had it not been for the malformation and the lethal effect of the chloroform, the removal of the kidney would have presented little trouble; but in this case the kidney structure was but slightly changed at the nephrotomy. In the first case, however, the kidney had been prac- tically converted into a pus sac, and there was slight ground to expect much function from it, and yet a very large amount of urine escaped daily from the sinus from the time of the operation until its removal. It could have been removed at the time of the nephrotomy, and I think I should have removed it, in spite of the general opinion against such a procedure, had the patient not been in such a feeble condition. In a similar case I should be disposed to do so, and yet only a few weeks ago I did a nephrotomy in which I allowed the kidney to remain on account of the feeble condition of the patient. He has progressed fairly so far, but the disease was a pyelitis and pyelo-nephrosis due to cystitis, due in turn to a traumatic stricture, and the cystitis not being entirely relieved, while the pyelitis had placed him in imminent danger, I felt that the lesser operation was all that was justifiable under the circumstances. He may improve so as to recover a fair degree of health without a nephrectomy; but should a nephrectomy become neces- sary, I should doubt its utility, from the fact that the changes in the peri-renal tissue from the peri-renal in- flammation, as shown by the sac-like condition of the kidney at the time of the operation, would render the procedure extremely difficult, possibly impracticable. Those who have not undertaken the removal of a kidney where there has been chronic peri-renal inflammation, so as to cause the ordinary anatomical and usually easily Separable layers of envelopes to be condensed into one mass with the Organ itself, can form but little conception of the difficulties of the procedure. It is quite possible that this class of cases may show that operations pro- duce a greater aggregate shortening than lengthening of 686 METAV YORK STATE MEDICAL ASSOOIATION. life, and so on any true view of the office of surgery should be allowed to pass on without interference. Ne- phrotomy alone is so simple a procedure that it will be justifiable in a large number of cases, for it will usually prolong life, and may occasionally cure, but in the oper- ation itself I feel that should the renal tissue be exten- sively destroyed, and the patient’s condition will justify the longer and more severe operation, it will occasionally be justifiable to remove the organ as a primary procedure. THE TREATMENT OF NEGLECTED CASES OF ROTARY, LATERAL CURVATURE OF THE SPINE. By REGINALD H. SAYRE, M.D., of New York County. November 15, 1892. The correct treatment of lateral curvature consists in never allowing a case to get into the condition of those I shall describe to you this evening. After the patient has become as distorted as those whose pictures I shall show, it is impossible to remove the deformity, and your efforts will simply be directed towards making the patient as free from distress as possible, and in concealing instead of remedying the deformity. These cases all begin very insidiously. One of the worst cases that I ever saw was said by her physician to have lateral curvature at a time when the mother—so she wrote me—could not believe that anything was the matter with this child’s spine ; and yet, in after years, when the case came to me for treatment, she was one of the most distorted cripples I have ever seen. When a mother brings a little child to you and asks if there is anything the matter with its Spine, do not glance at it hurriedly and Say, “There is nothing the matter with it; she will grow out of all that,” but strip the child to the hips, and let her stand in her own natural, easy attitude, giving her time to accustom herself to her surroundings, and allow her muscles to relax. In a few moments you will notice a dropping of one shoulder, and that the space between the body and the arms is not the same on both sides. When first in the presence of the physician these children very often hold themselves quite erect for a few moments, but after the first feeling 688 NEW YORK STATE MEDICAL ASSOCIATION. of strangeness has worn off, and their muscles grow a little fatigued, they will allow themselves to drop into the position which they habitually assume at home, and then, and not until then, is the slight deformity apparent. Let the child then stand in front of you, hold its legs between your knees, and, while its knees are straight, let it bend forward and try to touch the ground with its fingers. In this position, the scapulae fall forward and the contour of the back becomes visible (Fig. 1), so that slight degrees of rotation are thus perceptible which escape observation while the child is in the upright post- ure. This rotation is often more appreciable to the hand than to the eye. In a certain number of cases you will find that the starting-point of a lateral curvature is a deformity of the last lumbar and first Sacral vertebrae, and that the spine cants constantly to the right or left at the lumbo-Sacral junction. In some cases, the deformity is more apparent in front than in the back. You will notice a prominence of one hip, the flesh, at times, sinking in quite sharply above the iliac crest, although the deformity in the back is scarcely discernible. Among the earliest evidences of rotation, is the in- equality, which almost always exists, in the distance from the umbilicus to the two nipples. This is fre- Quently observed before any marked change in the back has taken place. You will also usually find that the breast on the side of the convexity is smaller than that on the side of the concavity. I have seen So many cases of bad lateral curvature, where the mothers told me that they noticed an in- equality in the two sides of the child when it was still young, but that on consulting a physician they were told that the child would “grow out of it,” that I feel I cannot too strongly impress upon you the necessity of observing these cases closely, and the importance of taking measures to straighten these incipient curves. TREATMENT OF LA TERAL CUR VATURE. 689 Rest assured, also, that if the child has a slight curve, it will not “grow out of it” as it grows older, but rather grow into it, and that when it comes to puberty, it will have so decided a change in the ribs and vertebrae that it will be impossible ever to wholly rectify the deformity. Fig. 1. The generally received opinion that lateral curvature develops between the ages of twelve and sixteen years, is largely due to the fact that girls have their clothes fitted more accurately at this time, and that in consequence, a curve that has been present for a number of years is first recognised – very possibly by the dressmaker—at this period. Moreover, the increased bone growth which 690 NEW YORK STATE MEDICAL ASSOCIATION. takes place at this age, causes the deformity to pro- gress much more rapidly in a few months than it may have done in the same number of preceding years. I believe that rickets is a much more prominent factor in the production of lateral curvature than is usually believed. We all recognise those marked cases of rickets in which the bones of the entire skeleton are more or less deformed, but I feel convinced that many of the lateral curvatures are due to a primary mal-nutrition which manifests itself in unequal growth of the bodies of the vertebrae, instead of finding its expression in the lower extremities, as is usually the case. The fact that these girls may be stout and well-nourished at the time they come to you for treatment, does not invalidate this statement, for after the active period of rickets has passed by, the subject may develop into a robust, healthy individual, simply bearing marks of his earlier disease, and it is a frequent occurrence to see stout, healthy men with aggravated bow-legs and other rickety deformities. In other cases, anterior poliomyelitis is the starting- point for lateral curvature. I do not mean those cases where there is a general involvement of the muscles, which passes by, leaving one side paralysed, but those milder cases in which the deeper muscles of the spine are involved, possibly to such a slight extent as to escape our observation, while yet establishing a want of equilibrium in the muscular supports of the spine sufficient to determine a lateral curvature, and one which will be most resistant to treatment. In some of the cases I shall describe this evening these conditions have been present, and in others the curvature has been consecutive to mal-formation of the ribs, to pleurisy with adhesions, or to other complications which we do not find in the true “idiopathic lateral curvature,” So-called. As I have said before, the most effective treatment for lateral curvature consists in preventing it, as, after the TREATMENT OF LATERAL CURVATURE. 691 occurrence of rotation and marked bone changes it is im- possible by any system of treatment ever to restore perfect symmetry. Some years ago I wrote more fully on this subject of “prevention.” But even in these badly distorted cases, although we cannot restore symmetry, we can render the patients vastly more comfortable, and can to a certain extent reduce their deformity. One of the great factors in causing rotary lateral curvature of the spine, after the equilibrium between the muscles of the trunk has been destroyed, that is, after the normal curves of the spinal column have been dis- turbed by some adventitious circumstance, is the super- incumbent weight of the head and shoulders; and no one can see many cases of lateral curvature without being forcibly struck by the difference in the contour of the body in the erect and prone positions. A patient who looks very crooked while standing, will often present a fairly symmetrical appearance while lying flat upon the face. In this spine which I now show you (Figs 2 and 3), which is a model devised by Dr. Judson to illustrate the action of the spinal muscles in causing rotation of the vertebrae, you will perceive that when I press the button there is a double curvature of the spine, like a letter S, accompanied by rotation of the vertebrae, one upon the other (Fig. 2), and you will notice that as long as I keep my hand pressed upon this button, and so represent the Weight of the head and shoulders pressing the spine more and more out of the perpendicular, my efforts to correct the curves by lateral pressure simply serve to change the long curves into a number of small ones, and that the spine is not made straight until I release the button and allow the two ends of the S to recede from each other (Fig. 3), or, in other words, take the weight Of the head and shoulders off the spine, and allow it to * New York Medical Journal, November 17, 1888. 44 692 NEW YORK STATE MEDICAL ASSOCIATION. º • * º * º ºf . §§2. º gº 3. § W. º | ºff % º *ś & º ºf 3. º º' anº º Q_º & 2 & ºt º & º ) Sº, , ; Zº & º º & º º º ||| *% | ſ' z. º . º : 22 3% ºf - º º &: º º: Af º: º D º 3tº tº - 2/3 & 2. ź º g º 22 2 |=Nº. #|##$º become straight. As soon as I pull on this spine, I Straighten it. The practical application of this principle is of the greatest assistance in eliminating the curves of the lateral curvature. The amount that one of these badly distorted spines will stretch while the patient partially suspends herself by means of a head-swing and pulley is surprising to one who has not measured it with a standard, and One of the most important problems that presents itself to us in the treatment of these cases is to find a suitable means of retaining the improved position gained by this self- Suspension. In my own experience, nothing has been so satisfactory for this purpose as a plaster of Paris jacket, and patients who have been wearing for many years a great variety of apparatus, applied by different gentlemen of large experi- ence, tell me that they find the corset more comfortable than steel braces; and as they increase in health and vigor as well as in height, as shown by actual measure- TREATMENT OF LATERAI, OUR VATURE. 693 ment, under treatment by suspension and plaster of Paris corsets, I am convinced of the superiority of this method of treatment over other mechanical means which simply serve to make lateral pressure against the ribs. In order to be effective in reducing the rotation of the spine, which in these cases is the most serious element t * 4.3 ° Fig. 4.—The arrow a shows the proper position for the application of force in reducing rotation of the vertebrae; the 'arrows b b show the improper direction. in the production of deformity, vastly exceeding in im- portance the lateral deviation of the spine, it is necessary that the force be transmited to the ribs in a direction away from the spinal column, and not towards it, as you Will see by the accompanying diagram (Fig. 4). If the 694 IVEW YORK STATE MEDICAL ASSOCIATION. force be directed as the arrow a points in Fig. 4, its tendency is to twist the vertebrae towards the straight position, whereas, if it impinges against the ribs, as shown by the arrows bb, it tends to curve the ribs more and more, and rotate the vertebrae in the wrong direction. This second result is what practically takes place in all portable, mechanical devices I have seen, which aim to push the ribs into a straight position. They do not practically carry out the principle which they are theoretically supposed to embody, and the force which is required to press these ribs into position is so great, if concentrated at a single point, as in these mechanical devices, that the pressure is more than can be endured by the skin, without damage ; and I, therefore, prefer to straighten the spine, as far as is practicable, by partial self-suspension, then to apply a plaster of Paris jacket while the patient is twisted as far as possible into the correct position, and thus distribute the pressure equally over the whole trunk. In this way I find that I can support the weight of the body with much greater com- fort to the patient, and much more efficiency than by metallic straps and pads. I have often compared this to pulling out an accordion and then preventing the accor- dion from collapsing by means of plaster of Paris. It has been objected to this principle that it practically does not keep the accordion from collapsing, so, with a view to settling this point, I have measured a number of extremely bad cases of lateral curvature before treat- ment and after they were supported in the plaster of Paris jacket. CASE I. E. O., fourteen years of age, whose picture I now pass around, is a very striking example of improvement. When first seen she was four feet eight and an eighth inches high. A plumb-line dropped from the chin went outside of the right foot in front, and behind ; a line from the nape of the neck passed one inch to the left of the inner border of the left scapula. In front, the left nipple lay to the right of the plumb-line dropped from the chin. After one month's exercise she measured four feet nine and a quarter inches in her corset, a gain of one and an eighth inches in one month. In three months' time she measured, TREATMENT OF LATERAL OUR VATURE. (395 \ 'º N | ſº | | i - | | / ** % # 3." º % | t ſ - | | •mūll) ºr * > y | }} } \ ºf Nas }* \s MIM]\\\\ \\\\\\º e Fig. 5. Fig. 6. without the corset, four feet nine and a quarter inches, and with the corset four feet ten and an eighth inches, being an increase in height of two inches made by suspension and kept by the corset. Her first corset is shown in Fig. 5, and her sixth corset in Fig. 6. CASE II. N. H., fourteen years of age. On October 3rd, 1891, she measured four feet six and three-quarter inches; after suspension, four feet Seven and three eighth inches. This gain in height from the first suspension was never entirely lost, as on the 5th of October she measured, before stretching, four feet seven and an eighth inches, after stretching, four feet Seven and a half inches. On October 7th she measured, after stretching, four feet seven and five-eighth inches. On October 12th, in her jacket, she measured four feet seven and seven-eighth inclies. On October 23rd a new jacket was applied, and in that she measured four feet eight inches, being a gain in less than one month of one and a quarter inches. This patient has one of the most distorted lateral curvatures I have ever seen. The deformity was congenital, and may possibly have been produced at birth, as it was a transverse presentation. When the child was six years of age she had pneumonia, followed by empyema on the right side. An in- cision was made between the ribs, and the pus evacuated. There seems to be an absence of ribs on the right side. The lower ribs project down below the crest of the ilium, and between them and the upper ribs is a W- shaped gap, through which the liver can be distinctly felt. It is possible that, instead of there being an absence of ribs on this side, they are so Crowded together as to give the impression that the full number is not present. The mother thinks that these ribs were torn apart at the birth of the child. 696 MEW YORK STATE MEDICALL ASSOCIATION. CASE III. C. M., fifteen years of age. On September 24th, 1891, height five feet one and one-eighth inch. On October 15th, height five feet one and seven-eighths inches. Gain in three weeks, three-quarters of an inch. CASE IV. E. N., fourteen years of age. On July 7th, 1891, height four feet eight inches. On July 30th, height four feet nine and one-half inches. Increase in three weeks, one and one-half inch. After stretching, height four feet ten and one-quarter inches. - August 5th, height in plaster of Paris corset, four feet ten and seven- eighths inches, an increase in less than a month, while supported by his corset, of two and seven-eighths inches.” CASE W. W. K., fifteen years of age. On February 13th, 1891, four feet nine and seven-eighths inches. After suspension, four feet ten and five-eighths inches. February 14th, suspended night and morning; height this evening, after suspension, four feet eleven and one-quarter inches, a gain in one day of one inch and three-eighths. - February 20th, applied plaster of Paris corset. Patient has been exer- cised daily and suspended ; height to-day, before suspension, four feet ten and one-quarter inches; after suspension, and with corset, four feet eleven and three-quarter inches. February 24th, before suspension, without jacket, four feet eleven and five-eighths inches; after suspension, with jacket, five feet one-quar- ter inch. March 2d, before suspension, without jacket, five feet one-eighth inch ; after suspension, with the corset, five feet one-quarter inch, being an increase in height in less than a month, of two and one-quarter inches in actual height, and two and three-eighths inches in his height when the corset was applied. CASE WI. K. M., thirteen years of age, April; 19th, 1892. Height be- fore suspension, four feet four and three-quarter inches; after suspension, four feet five and three-eighths inches. In October, height, without corset, four feet, six and three-eighths inches; with corset, height four feet seven and one-half inches. (See Figs. A, B, C, D, E, F, G.) CASE WII. R. W., seventeen years of age. On September 28th, 1892, he came to me wearing a metal support, which was designed to make lateral pressure against his ribs, and which, from its construction, seemed to me to be more efficient in compressing than in elongating his spine. I re- quested his father to take the boy’s height in his brace in my office, and he measured four feet eight inches; on removing his brace he measured four 1,This patient was shown after reading the paper. He measured without his corset five feet one inch. A new plaster of Paris corset was then put on him, and he then meas- ured five feet two and seven-eighths inches, an increase of one inch and seven-eighths. TREATMENT OF LATERAL OUR VATURE. 697 feet eight and five-eighths inches. He was then suspended, and after suspension, measured four feet eight and seven-eighths inches. This is not the first case I have seen in which the patient was more crooked in his ap- paratus than when left to nature. This patient suspended himself daily until October 10th, when a plaster of Paris corset was applied, and in it he measured four feet nine and one-eighth inches, being an increase in two weeks' time of one inch and one-eighth of his height in his plaster corset over his height in his iron brace. CASE VIII. H. R., nineteen years of age, had spinal meningitis at the age of three years which left him paralysed in various muscles of the trunk and lower extremities. During convalescence he was allowed to sit in bed propped up by pillows, and so developed a lateral curvature. He was treated with a plaster of Paris corset and by braces for some time, when his mother, becoming dissatisfied, sought other advice, and for years he wore iron spinal braces of diverse kinds. After a length of time, he came under observation once more, this time with an aggravated lateral curva- ture, as you see in this photograph. His muscles are incapable of holding the trunk upright, without artificial support, and I have tried wood, leather and silicate jackets on him, but he says he prefers plaster of Paris. I thought he looked much taller in his corset, and so wrote, asking him to have his height taken, and send it to me. To day I received the following letter : - “YALE UNIVERSITY, \ November 14th, 1892. , “Just received your letter, and in reply would say that when I got my new jacket on for the first time, I knew from the feeling there must be a large difference in my height for I no longer felt a little man, but rather that I had been drawn out by weight at bottom and pullies at top, to an enormous height ; so, being anxious to know the exact fact, I measured myself accurately and found to my great delight, as well as surprise, that with my new jacket on (also shoes) I was five feet nine inches—how's that for a stretch 7 Taking off my jacket, my height (with shoes) is five feet Seven and one-eighth inches, making a clear gain of one and seven-eighths inch. I now have hopes of reaching six feet some day by a good stretch. “P. S. Since I received your letter, I have measured again with the Same result.” CASE IX. Emma D., twenty years of age. On March 23d, 1886, She measured four feet six inches. - March 30th. Patient has been suspended twice daily for a week; to-day a plaster of Paris corset was applied ; height in corset, four feet eight and one-eighth inches, an increase in height of two and one-eighth inches, and a decrease around the waist of four and one-half inches. September 27th, height, without corset, four feet seven inches. October 1st, new corset applied ; height in it, four feet nine and one- eighth inches. (See Figs. H, I, K, L.) This patient was a most aggravated case of lateral Curvature following infantile paralysis at the age of eight years, which gradually passed off, leaving a few of the 698 NEW YORK STATE MEDICAL ASSOCIATION. muscles of the trunk impaired. From the age of nine she had always worn braces of some description, and had grown steadily worse during this time. You will notice in this case, as in all the others, that a marked increase in height takes place at the first few suspensions, but that after the initial gain the subse- quent increase in height is only trifling. Of course, in the younger patients, the increase in height which is ob- served after the lapse of several months is attributable, in part, to the natural growth of the body, but in a woman of twenty the latter factor does not enter into consideration, and she is only one of a number of cases in which similar increase in height has been noticed. I was long ago struck with the very great change made in the spines of these patients by self-suspension, but it was not until I had carefully examined the heights of a number, both before and after suspension, and with and without corsets, that I realised the enormous difference made by treatment, the increase in many instances being so great that I should have been inclined to discredit the observation had I not made it personally. In one case, with great distortion, in which there was a marked presystolic and systolic murmur at the apex of the heart, with great shortness of breath on exercise, and pain in the right side on coughing, I noticed that while the patient was suspended in the swing, the pulse beats dropped from 140 to 122, from 144 to 116, from 122 to 100, from 100 to 86 on various occasions. Every time I noted the pulse, it was from 18 to 28 beats slower while suspended than when the patient was down; and with the jacket applied, while it was not so slow as during sus- pension, it was much less rapid than when the jacket was not on—from 6 to 20 beats slower. This I attributed to the fact that the heart was not so compressed, and was therefore in better condition to perform its functions. She noticed herself that her breath was not so short, and that she was much better able to take exercise while supported by the corset. Severe lateral curvature, showing effect of self- suspension and gain in height of five-eighths of an inch retained by plaster of Paris corset. FIG. A. FIG. C. FIG. B. FIG. D. FIG. E. ' , , \, , , , , Fig. G. FIG. F. Severe lateral curvature following infantile paralysis, showing gain in height of three and one-eighth inches from self-suspension retained by plaster of Paris corset. Fig. K. FIG. L. TREATMENT OF LATERA L OUR VATURE. 699 I have noticed a similar slowing of the pulse in other cases, but never to so marked an extent, and I have often had patients remark the greater ease of breathing and the relief of pain in the side while supported by their COrsetS. - While self-suspension, in the manner I have indicated, is a most useful means of diminishing the curvature of the spine, it is not practicable for a patient to suspend herself for a long period of time; and, in many cases, I am accustomed to add to self-suspension, Suspension by means of a weight and pulley attached to a chin-piece, which is fastened to the patient’s head while she lies on her back on an inclined plane which is slightly convex. The father of one of my patients has devised a most beautifully constructed folding couch to be used for this purpose, and which I show here. It is capable of being taken apart and carried in a trunk, so that this treatment can be constantly employed even during the summer while the patient is away from home. In correcting the rotation which, as I have before re- marked, is a vastly more prominent element in the pro- duction of deformity than the lateral deviation of the Spine, I find great benefit from having the patient lie face downward upon the floor or a firm table covered with a thick rug, while I make strong pressure upon the projecting scapula, pushing in a direction forward and away from the central line of the body, so as to rotate the vertebrae towards the median line (Fig. 4a). In some cases I allow the patient to lie for half an hour in this position with a sand-bag weighing twenty or thirty pounds resting upon the shoulder, if it can be placed so that the Weight falls in the proper direction. To correct rotation, Dr. Beeley, of Berlin, has devised a frame in which the patient leans forward, with the elbows resting upon a couch, while the back is parallel with the floor—very much in the position of a boy playing leap- frog–while a strap passes across the back, sustaining a heavy weight at its end. The objection to it is that the 700 NEW YORK STATE MEDICAL ASSOOIATION, weight instead of twisting the spine around in the proper direction acts to compress the ribs laterally, which objec- tion Schede has recently tried to overcome in an apparatus of his devising, by attaching the weight to broad bands of adhesive plaster which are secured to the walls of the chest. By these he endeavors to twist the spine around a perpendicular axis, while the hips and shoulders are held immovably fixed by means of iron props extending from a circular frame which passes around the patient. I have had no personal experience with Schede's apparatus or with that of Bradford, which is designed to accomplish very much the same purpose, but I have been able with my hands to produce this twisting of the spine. In Bradford’s apparatus the patient is partially suspended by the hands and arms, the pelvis being firmly fixed on a chair by means of a large screw. Pres- sure is made against the chest walls at different points by means of padded screws which pass from a circular band of iron which encircles the thorax, at some distance from it, and is firmly fastened to two uprights passing from the chair. In correcting the rotation of the spine, any apparatus of this sort must pass to the floor for a base of support ; and all the machines which have been designed to rotate the upper part of the thorax, while the machine takes its point of origin from the pelvis or thighs, are futile, and are lacking in the mechanical power to perform the work they are called upon to do. All that any machine fastened to the body can do is to retain the improved position which is gained by manipulation or force applied from some fixed point outside the body, and to obtain this improved position I am fully convinced that appara- tus in the form of a corset, which completely encircles the body, is preferable to those appliances which make prºssure merely at certain points. The material of which this corset is to be made is not of vital importance, provided it is light and strong and not impervious to the air. I personally prefer the plaster TREATMENT OF LATERAI, OUR WATURE. 701 of Paris corset as being perfectly efficient and vastly easier to construct than anything else. The wood corset of Waltuch, if properly made, is as firm as the plaster jacket and a little lighter; but as usually constructed, it does not retain its shape, but warps, and when exposed to the heat of the body is very apt to separate into its component layers. The leather jackets, I have found, are also apt to curl up along the edges, and in summer time frequently acquire a disagreeable odor. The same is true of those made of rawhide. The silicate of soda jackets are lighter than those of plaster of Paris, but have the objection that they retain the perspiration on the body, and act more or less as a poultice. The wire corset is very much cooler than anything else, and, in certain cases, is probably the most comfortable retentive appliance, but in others it does not retain the increase in height so well as a more solid material. In one of the cases I report this evening, who is now wearing a wire corset, the height is seven-eighths of an inch less than while she wore one of plaster of Paris. The great objection, however, which I would urge against all these forms of appliance is the difficulty with which they are constructed. A plaster of Paris corset has, first of all, to be made, in which a cast is made, and Over the latter the leather, felt, wood, paper, celluloid, Water-glass, or wire corset is constructed, requiring either the services of an instrument-maker or the expenditure of a great deal of time by the physician himself, and to those who are not living in the large business centres, all of these appliances are much more difficult to manufact- ure than the ordinary plaster of Paris corset. In cases of marked distortion, and for small children, these second Casts do not fit so accurately as those made directly on the body. Properly made, the latter, for a girl of six- teen, should weigh from two and a half to two and three Quarters pounds, or, if very heavy, three pounds; and Yet I have frequently seen plaster corsets which weighed from ten to twelve pounds. If the best dental plaster 702 JWEW YORK STATE MEDICAL ASSOCIATION. be used, and well rubbed by hand into the meshes of crinoline from which the sizing has been previously re- moved by washing, and care be taken not to roll the bandage too tightly or to put in too much plaster of Paris, a corset ought never to weigh more than four pounds for the largest person ; and those who complain of want of success, and produce corsets like the one I here show you, should only blame themselves for inabil- ity to learn the proper manner of making a plaster of Paris corset. - You see that this one is like a section of the wall of a house. It is almost solid plaster throughout, and in- capable of being bent, and is not shaped to the patient’s figure. On the other hand, I occasionally meet with corsets which seem to consist almost wholly of crinoline, contain no plaster of Paris in the meshes, and are as useless as a handkerchief tied around the body. Or- dinarily, it is the failure to use plaster of Paris properly which makes physicians resort to felt and leather. In putting the jacket on, it is important in these greatly distorted cases that the patients should be sus- pended some little time before the corset is made, in order to gain as good a position as possible. Just before beginning the application of the bandages, the patient may come down and rest for a few moments, if the neck be tired, and then stretch up to the fullest extent pos- sible. The physician sits behind the patient and grasps her legs tightly between his knees so as to steady the pelvis, and then applies the bandages, beginning at the waist, and passing from left to right in the ordinary cases of lateral curvature in which the right shoulder is prominent, as putting the bandages around the body in this direction tends to remove the rotation. It is often desirable to have an assistant push the prominent shoulder forward, and hold it in this position, untwist- ing the rotation as it were, while the jacket is applied. It is always best to have an assistant in front of the patient to keep the bandages smooth as they are applied, TREATMENT OF LATERA L OUR VATURE. 703 and rub the layers together very thoroughly. The bandages should be put, one at a time, in water of about blood-heat, end up, the length of time required to put on one bandage being about the proper time during which the next one should soak. For padding the hips, I use piano felt, made by Alfred Dolge, 120 East Thir- teenth street; it costs $1.50 per pound. This quality is too thick to be used for padding unless split in two. The knitted shirts which are put on next to the skin, and on which the best jackets are made, are knitted for me by the Lawson Company, 783 Broadway, and come down to the knees. The end of the shirt is reversed after the jacket has been trimmed out, and is stitched along the upper edge, thus completely covering in the plaster of Paris. The ordinary Jersey-fitting underwear can be used for this purpose in case of necessity. Between the jacket and the skin, I slide a thin piece of tin, two inches wide, as I can cut the jackets down much more easily and quickly with this protection, and it also adds greatly to the patient’s feeling of security. In growing girls and adult females, it is necessary to put pads over the breasts; except in the case of very thin people or little children, the “ dinner pad” is usually not neces- sary. It takes from twelve to fifteen minutes to com- plete a plaster jacket. As soon as the jacket is made, it is cut down in front on the piece of tin which passes down the median line of the body, and is then removed. In almost all cases, a thin slice is taken off each edge, as, except in very thin persons, it is impossible to draw the bandages quite tightly enough in the waist without making wrinkles; and the addition of the kid which covers the edge of the jacket, also makes it a little too large unless this slice be removed. The edgets of the jacket are then brought together, and retained in posi- tion by an ordinary roller bandage. If the weather be Very damp, the jacket may be laid near the fire to dry; in ordinary weather, this is not necessary. The next day, the patient suspends herself again, and 704 NEW YORK STATE MEDICAL ASSOOIATION. the corset is put on, and fastened with a roller bandage. It is then trimmed out under the arms and over the front of the thighs until the patient can move her arms and legs with comfort. After the jacket has been trimmed out, and the end of the shirt reversed over the plaster of Paris, the shirt is stitched to itself along the free border of the corset. The front edges are bound with kid pasted over the stitching, and a piece of leather con- taining hooks, such as are used upon shoes, is sewed with an awl and ºliº ºš waxed thread along each edge of the ºf corset, the stitching passing through ºf and through the plaster of Paris. ) ; (Fig. 7.) Additional strength is given : A to the jacket if this leather be wide º enough to cover a thin strip of corset ºffl steel, half an inch wide, which is \s(* placed under it. In exceptional sº cases of great deformity, it is some- Fig. 7. times necessary to fasten a strip of thin steel on the outside at the point where most strain is thrown. If the cases be very badly deformed, it is expedient to put padding inside of the shirt when it is reversed, in order to make the jacket as symmetrical as possible, and thus avoid the necessity of padding the clothes. The corset having been made while the patient is stretched out, it should always be applied to the patient in this position. For this purpose, the patient is pro- vided with a pulley-wheel and head swing at home by which she can suspend herself in the morning, while the corset is applied by some member of the family, and re- tained in position by lacings joining the hooks on the front of the jacket. The lacing should pass first around the two central hooks at the waist, and then run down to the bottom, be reversed, and pass up again to the top. Applied in this manner, the corset fits better than if the lacing is begun at either end. It is a mistake to cut cor- sets down in two places, as I have frequently seen done TREATMENT OF LATERAL OUR VATURE. 705 and the corset should not be made so stiff as to render it impossible to remove it unless it is cut in two places. I show you here two little plaster of Paris jackets which have been made over a tumbler; the tumbler then being removed, the open end of the box has been covered with more plaster of Paris bandages. In the end of each box is a hole which admits the stem of a tobacco pipe. One of these boxes is varnished, and the other has been left unvarnished, as all plaster of Paris jackets should be. You will notice that when I blow smoke through the pipe into the unvarnished box, the smoke passes through the plaster of Paris on all sides; while, when I blow smoke in a similar manner into the varnished box, it re- mains inside, showing that this box is impervious to air. As I have seen, in medical journals, articles advising the application of shellac to plaster jackets in order to render them more durable, I wish to draw your attention to the folly of this procedure, as a jacket thus rendered impervious to air becomes a poultice. In one instance, which came under my father's observation, the whole epidermis peeled off on the removal of a solid plaster jacket which had been coated in this manner. - The same objection, the impermeability to air, applies to the silicate of soda and leather jackets, unless they are punched full of holes. Some of these cases of great distortion, especially those dependent on paralysis, require artificial support as long as they live, but others may have their muscles developed to Such an extent that they can dispense with artificial aid. The following are among the exercises I have found most useful in these cases. They may be repeated three times each at the commencement, and later on a greater number of times, stopping short of fatigue in all cases. In beginning the exercises a mat or thick shawl is laid On the floor and the patient lies prone, the arms at right angles to the trunk, palms down, face turned to the Convex side, and the back as straight as possible (see Fig. 8). The patient supinates the hands, throws the 706 ME W YORK STATE MEDICAL ASSOCIATION. scapulae well back, raises the hands from the floor, and lifts the trunk, while the surgeon holds the feet down (see Fig. 9). This is repeated three times; later on it can be done oftener. The breath should not be held during any of these exercises, but the patient should breathe naturally. If necessary to secure this, make them count out loud while exercising. With the hands behind the head, the patient raises the elbows from the floor, and raises the trunk as before, the feet being held by the surgeon (see Fig. 10). With the hands behind the head and the elbows raised, the body is swayed toward the convex side, the patient trying to “pucker in ’’ the bulging ribs and not to bend in the lumbar concavity. The feet are fixed as before. With the arm on the side of the convexity under the body, the other arm over the head, the heels fixed, the patient raises the trunk from the floor. Sometimes the arm on the side of the concavity is put on the opposite buttock (see Fig. 11), while the patient raises the trunk (see Fig. 12). Sometimes the arm on the convex side is put on the buttock (see Figs. 13 and 14), and in cases of marked lordosis, with great stooping of the shoulders, both hands are put on the buttocks while the patient raises the trunk. TREATMENT OF LATERAL OUR VATURE. 707 The patient now lies on the back, arms at the sides, palms up, and lifts first one foot in the air, while the surgeon makes resistance graduated to the patient’s Fig. 9. power; repeated, say, five times. The same is done with the other foot, and then with both. The feet are next ſº "... - WWN ~ - } \ 㺠º 2-ºº:Z aſº-Zºzz,223) -: Ž% ->É º SSºº [- Eig. 10. Separated and then brought together once more while the Surgeon resists. Each leg then describes a circle, first from within out, then from without in. 45 708 NEW YORK STATE MEDICAL ASSOCIATION. ** &^ tº sº Ns “f*$2. N sº Fig. 11. If there is special weakness at the ankles, with a ten- dency to flat-foot, the patient flexes the foot and extends it against resistance, and turns the sole of the foot toward its neighbor, the surgeon resisting ; and it is then forcibly everted again by the surgeon, the patient resisting. - The patient now lifts the arms from the sides, passing perpendicularly to the floor till they are stretched as far beyond the head as possible, and then, going at right angles to the trunk and parallel with the floor, returns them to the sides, palms up. Fig. 12. When the heels are held, the patient rises to the sit- ting position, hands at the sides; then she rises from the floor with the hands behind the head and the elbows at right angles to the trunk. TREATMENT OF LATERA L OUR VATURE. 709 The patient now stands with the heels together, toes turned slightly out, hands behind the head, elbows at right angles to the trunk (see Fig. 15); then rises on tip-toe, bends the knees and hips, keeping the back as straight and erect as possible, and rises up once more. With the arm on the concave side high above the head, the arm on the convex side at right angles to the body (see Fig. 16), she rises on tip-toe, bends the hips, knees, el * h. •--> - - sº ºs, -º/* ** sºs ss=s= T- * * Fig. 14. and ankles So as to Squat, then rises and stands. All this time care must be taken to push the body as straight as possible, and gradually educate the patient to hold it So without Wriggling during these movements. Let the patient practice walk- ing in these positions, both on the flat foot and tip-toe, and also Step high, as if walking up- stairs. With the palm of the patient’s hand on the convex side against the ribs, pushing them in, the hand on the con- Cave side, she pushes a slight Žiž º Weight up in the air, while the | / | body swings so as to straighten - | ** .." # * AN º *W \\ Out the curves. Fig. 15. 710 JNETW YORK STATE MEDICAL ASSOCIATION. Sit behind the patient, fix her thighs with your knees, while she holds both arms above the head and bows toward the floor, keeping her knees stiff while you keep her ribs as straight as possible with your hands. With the arm on the concave side across the top of the head, and the arm on the convex side around in front of the abdomen, the patient bends to the convex side through the ribs and not through the waist (see Fig. 17). The patient sitting with the back toward the surgeon, the latter pushes one hand against the most projecting part of the convexity, and, with the other hand passed under the shoulder of the concave side, straightens out the curve as much as possible, the hand on the “bulge” acting as a fulcrum in Straightening the curve. The patient sits on a stool in front of the surgeon, who fixes the pelvis with his knees. The patient then twists the projecting shoulder to the front while the surgeon holds the elbows, which are at right angles to the trunk, the hands being behind the head, and makes resistance. TREATMENT OF LATERA I, OUR WATURE. 711 In the same position the patient swings forward and back, Swinging through the hips, keeping the back stiff, and not bending in the waist. - The patient pushes in the ribs on the convex side with the hand, and pushes up with the hand on the concave side, the same as when standing. She also lifts the arm on the concave side up at right angles with the body while holding a weight. In cases of round shoulders, wind- mill motions of both arms and to-and- fro movements of the head against re- sistance are advisable. The patient lies prone on the couch, all the body above the waist projecting from it, while the surgeon holds the feels. With the hands behind the head, the elbows thrown back, the body is bent toward the floor, then raised up ; later on, resistance is made by the surgeon. The patient lies on the concave side and rises up later- ally. The patient lies with the convexity on the edge of the couch, and hangs off as far and as long as possible. One of the best exercises for removing the curve is for the patient to place the head in a collar attached to a cross-bar above the head suspended from the ceiling by a compound pulley and rope. The patient now grasps the rope as high up as possible, and pulls up hand over hand until the toes iust touch the floor (Figs. D and E). While hanging thus she takes three deep, full, slow in- spirations and expirations. While she is hanging thus the surgeon corrects the rotation by pushing the ribs with one hand while he steadies the pelvis with the other. Another good thing is for the patient to have a belt passing around the pelvis, with a handle at each side. Holding these in the hands, she straightens the arms out, and the spinal column is thus stretched and straightened much in the same way as by self-suspension. Fig. 17. 712 NEW YORK STATE MEDICAL ASSOCIATION. The patient stands bent forward as if playing leap- frog, her hands on a chair, while the surgeon, with one hand under the shoulder on the convex side and one hand on the projecting ribs, corrects the rotation. It is advis- able to steady the patient with the knee while doing this. In keeping a record of cases, I find that photography is a great help, and I also make use of tracings of the thorax, taken while the patient is bending forward with the arms drooped toward the floor. These tracings can be taken either with a piece of flexible lead tape or with this machine, invented by Dr. Beeley, of Berlin, which consists of a number of steel rods, sliding loosely upon each other, whose points conform to the outlines of the trunk when the apparatus is pressed upon the back at right angles to the long axis of the body, and held per- pendicular to the floor, after the manner of the machines used by hatters in getting an outline of the head. By means of a lever, the steel rods are then locked in posi- tion, and the machine is laid upon a piece of paper placed on a thin sheet of felt ; then, with a little roller, the teeth on the under surface of the steel rods are pressed into the piece of paper, forming a line which gives the outline of the back at the level where the instrument was applied. By taking the outline of the trunk at each vertebra, in this manner, the difference in outline of the trunk at different portions and at different times can be recorded; and such tracings, taken at intervals of Several months, serve as excellent records of the progress of the case. This method is, however, very much more tedious than photography, and I employ the latter most frequently. The following method of taking an outline of the entire circumference of the thorax has been recommended and employed by Dr. Mary Putnam Jacobi ; it gives a cross Section of the body at any given point. A piece of flexible metal tape, provided with a hinge in the centre, is passed around the body at any desired point, and made to closely conform to the contour of the thorax. It is then removed by opening the hinge, laid TREATMENT OF LATERAL OUR VATURE. 713 upon a smooth table, the ends of the tape being brought into the same position they occupied when on the body, and plaster of Paris mixed with water to the consistence of cream is poured into the space enclosed by the tape until it is completely filled to the upper edge of the lat- ter. When the plaster of Paris has set, the tape is removed, leaving a thin slice of plaster of Paris, which represents accurately a transverse section of the body at the point at which the tape is applied. In these sections which I show you, and which were made in this manner, the rotation of the spine is very conspicuous, and the sharp angle of the ribs is clearly brought out. I have marked on these sections the line corresponding to the antero-posterior and lateral diameters of the body, and the sections through the mid- dorsal region show excellently the great increase of one oblique diameter and diminution of the other, with prom- inence of the right scapula; while the section through the lumbar region shows the exact reverse of this condition. These sections show very clearly the very adverse cir- cumstances under which the heart and lungs labor in performing their functions in advanced lateral curvature, and no one can perform per- cussion or auscultation on one of these chests without being struck with the unusual num- ber of abnormal sounds. Dis- orders of digestion are also of very frequent occurrence, and many of the cases suffer from severe neuralgias, due to pres- sure on the intercostal nerves as they emerge from the fora- mina of exit between the vertebrae. Here is a preparation which shows very clearly the great 714. NEW YORK STATE MEDICAL ASSOCIATION. compression which sometimes takes place between the ribs, and also how the bodies of the vertebrae may be rota- ted around the perpendicular axis of the body, almost to a right angle (Fig. 18). You will observe that the lumbar and cervical vertebrae in this preparation are in the same plane, while those in the dorsal region are rotated at an angle of 85°, and the ribs are so compressed against the bodies of the vertebrae that one wonders how the lungs managed to expand at all. The rotation in this case was So sharp that during life the projection was mistaken by a number of gentlemen who examined him, for an antero- posterior curvature of Pott's disease, the angles of the ribs being mistaken for the spinous processes of the Vertebrae. In exceptional instances, where the ribs are so twisted as to press against each other or against the crest of the ilium, it may be necessary to resect one or more ribs in order to give relief from pain in some cases, and in others, to avoid caries from pressure. While I formerly thought that many of these cases were so distorted that it was useless to attempt to treat them, I have, in a number of instances, yielded to their solicitations, applied plaster of Paris jackets, and com- menced a system of exercise, with so much benefit to them that I have now changed my mind, and have come to the conclusion that I have yet to see a case of lateral curvature so bad that it cannot be rendered more Com- fortable by treatment. If we can make these miserable cripples less unsightly, can help them to conceal their deformity, or can relieve it, even in a moderate degree, the result is well worth the time and trouble spent upon them. JDISCUSSIOW. 715 DISCUSSION. DR. DOUGLAS AYREs, of Montgomery county, asked for the author's opinion regarding paper jackets made over plaster casts. DR. SAYRE replied that the paper jacket was used about a dozen years ago by Dr. Vance, of Louisville, and while it possesses the merit of great lightness, it has the disadvantage of being impermeable, like the shellac and plaster of Paris jackets, and of being very difficult to make. Jackets may be made of paper, celluloid, wire, or wood, but the wire jacket must be given the preference on the score of coolness, although it does not give quite as good support. Thus, the girl whose picture he had just shown, gained three and a half inches in about one year while wearing the plaster of Paris jackets. She then changed to a wire jacket, and with this on she measured seven-eighths of an inch less than when wearing the plaster jacket. Notwithstanding this, it was so much cooler that she preferred to wear it. The construction of the wire jacket demands the services of a skilled mechanic, and hence it is not so well adapted for use in country practice. The objection to all jackets made over a second cast is that the imprint is not so sharp, just as the hundredth imprint from an engraving is not as sharp as the first impression. Even slight variations are quite important in the treatment of children. The wood and paper jackets are lighter than the plaster of Paris ones, but they must be punched full of holes. There are objections to all the various forms of jackets : plaster of Paris softens; leather curls, and sometimes softens; wood warps, and wire rusts, even though nickel plated. For steady, every-day use he preferred the plaster of Paris jacket to all the others. In answer to questions from DR. FERGUSON, Dr. Sayre said that the life of a plaster jacket when it is not necessary to make changes for alteration in the figure, depends very largely upon the patient. In making a plaster jacket, he ordinarily employed about twelve bandages three inches wide, and about fourteen yards long ; he generally used about five or six layers of the crinoline, and rubbed the layers together well with his hands to prevent the jackets from crumbling to pieces. MEMOIR OF ABRAM DU BOIS, M. D. BY SAMUEL S. PURPLE, M. D., OF NEW YORK COUNTY. With a portrait. Read November 17, 1892. On the twenty-ninth day of August, 1891, Dr. Abram Du Bois, of the city of New York, died. He was one of the founders of the New York State Medical Association, and a distinguished member of the medical profession. He was cut down by the grim messenger, like a shock of corn ripe in its season. It is a wise custom, fragrant with Sweet influence, that makes it a duty, at our annual meetings, to halt for a brief period from our scientific labors, and pay a dutiful tribute to the memory of departed members, to enumerate their virtues and commemorate their labors. To the personal friends of Dr. Du Bois but little can be said which will add to the sum of their recollections of his generous impulses and many virtues, but there are those here who to-day are enjoying the fruits of his wise counsels and the benefits of his earnest and indefatigable labors, and who are not familiar with the events of his life. On Dr. Du Bois' paternal side he was of French Huguenot descent, his first ancestor in America being Jaques Du Bois, father of Peter Du Bois, who was born in Holland in 1674, and came to America the same year with his parents, and finally settled in Wiltwyck, now Kingston, N. Y. He married Janneke Burhans. The subject of our sketch was a descendant of Jaques Du Bois in the fifth generation, and was the fourth son of Coert Du Bois and Mary Thorn. He was born in Red Hook, Dutchess County, N. Y., on the fifth day of April, 1810. Shortly after his birth his parents removed to Rhinebeck, where he remained until he was fifteen years old. He was then sent to a private School kept by a Mr. Holcomb at Granby, Ct., where he was fitted for col- lege. In 1827-28 he entered the sophomore class of Washington (now Trinity) College in Hartford, Ct. He was graduated in arts from that in- stitution in 1830, and returned then to Rhinebeck, where he commenced the study of medicine under the direction of Drs. Platt and Nelson. In 1832, by the advice of Dr. Nelson, he came to this city and entered the office of Dr. John Kearny Rodgers, as a pupil. He found in Dr. Rodgers an able teacher and a kind and ever valued friend. It was to him, as he once said to me, that he was largely indebted for the success he afterwards attained. He always remembered this kindness, as shown in his request to his OWn family shortly before his death. In 1832 he entered as a student the College of Physicians and Surgeons, then located in Barclay street, and in which his preceptor was demonstrator || | | | | | | | |- T , T% | ſae ſºſ ſae % ſ. } % ·# T , T % | | | T W | ||| || ſ. , |( |( |() ) ſae. --~~~~ --~~~~ ------ --- MEMOIR OF ABRAMſ DU BOIS, M. D. 717 of anatomy. He received the degree of doctor of medicine from that insti- tution in 1835. It was during the last two years of his pupilage that he discharged the duties of an assistant to Dr. Benjamin Ogden, who was then resident physician of Bellevue Alms House Hospital. In the July following his graduation, with the advice of his friend and preceptor, he sailed from New York for Paris, where he followed with diligence and commendable assiduity the clinics of Louis, Andral and Chomel, in medicine, and Welpau, Lisfranç and Sichel, in Surgery. He returned to New York in the month of December, 1836, and shortly after, he and his former associate, Dr. D. L. Eigenbrodt, received the appointment of assistant resident physicians to Bellevue Hospital, which was still under the care of Dr. Ogden. Soon after entering upon their duties in that hospital, Dr. Ogden was appointed resident physician of Bloomingdale Asylum for the Insane, and while nom- inally retaining the position of resident physician, he relinquished the duties and compensation incident to the office, to Drs. Du Bois and Eigenbrodt. He often said that this appointment was of the greatest value to him, as it afforded him ample opportunity for testing, in daily practice, the views of Louis and other distinguished teachers of Paris. During this second residence in Bellevue an epidemic of typhoid fever prevailed in this city, and the wards of the hospital were filled with pa- tients suffering from this disease. The physicians of the city, he told me, named it jail fever, ship fever, and camp fever, and their treatment con- sisted in bleeding, and in administering calomel, James powder, spiritus mindereris, etc. Dr. Du Bois and his associate, Dr. John A. Swett, who was also his fellow student while in Paris, advised that a long, narrow, two story building on the hospital grounds, which had been formerly used for small-pox cases, be converted into a fever ward. This building was thoroughly fumigated, cleansed and refurnished, and all typhoid cases were transferred at once to it. The treatment in vogue at that time was changed to the following: Cold sponging, cooling effervescent drinks, plenty of fresh air until the fever had subsided, and then small doses of quinine, with more nourishing food and stimulants. Under this treatment the mortality greatly diminished, and it continued to do sountil the epidemic ceased. As an evidence of the virulence of the epidemic, it may be said that Dr. Du Bois and Dr. Swett were both attacked with the disease, but recovered. He has often told me that the experience in the treatment of diseases he acquired during his residence in this hospital was of the greatest service to him in after years of practice. On retiring from the manage- ment of the hospital, the commissioners of the Alms House, in appreciation of his valuable services, presented him with a valuable case of Surgical in- struments, accompanied by appropriate resolutions. On the eighth of November, 1838, he married Catharine M. Brinkerhoff, of Fishkill, N. Y., who proved a most worthy and loving companion, and who with two sons and one daughter, mourn his departure. Dr. Du Bois, Owing to his close relations and intimate friendship with Dr. Rodgers, became strongly interested in ophthalmic medicine and surgery, and While in Paris listened attentively to the lectures and clinics of Jules Sichel, the 718 NETW YORK STATE MEDICAL ASSOCIATION. most eminent practitioner and teacher of ophthalmic medicine of that day. In his preceptor's more important operations upon the eye, he was his as- sistant, and these relations led to his appointment in 1843 as surgeon of the New York Eye Infirmary, then under the direction of Drs. Delafield, Rodg- ers and Wilkes, and located at 47 Howard street, New York. It was here that I made his acquaintance in 1844, while attending the clinic of the In- firmary. It was my privilege, as well as pleasure, to listen there to his teachings and to observe the results of his skillful treatment. As surgeon, secretary, trustee and vice-president he served this institution faithfully for forty-eight years, or up to the time of his death. He ever felt a warm and enduring interest in the institution, as evidenced by his large contributions toward its support and development, which interest has been most gener- ously continued by the surviving members of his family. Dr. Du Bois held numerous offices of honor and trust in the profession and society. He was consulting surgeon to the New York Institution for the Blind ; consulting surgeon to the Northern Dispensary; consulting phy- sician to the Home for Incurables; honorary fellow and benefactor of the New York Academy of Medicine; honorary member of the New York Medical and Surgical Society; founder of the New York State Medical Association ; founder of the New York County Medical Association; mem- ber of the Saint Nicholas Society; life member of the New York Historical Society; benefactor of the New York Society for the Relief of Widows and Orphans of Medical Men ; honorary member of the New York Physi- cians' Mutual Aid Association; honorary member of the American Ophthal- mological Society ; life member of the Charity Organisation Society, and life member of the Huguenot Society of America. In the formation of the library of this last named society he contributed liberal and important aid. We have said that Abram Du Bois became a pupil of Dr. John Kearny Rodgers, and here permit me to say a few words of this honorable member of the profession. He was one of the most accomplished surgeons and skillful physicians who has graced the profession of this city. He was the grandson of that eloquent, popular and devout clergyman of this city, the Bev. John Rodgers, D. D. His father was Dr. John R. B. Rodgers, a graduate in medicine of the University of Edinburgh in 1785, a distinguished patriot and surgeon of the American Revolution, and Professor of Obstetrics in the first medical school established by Columbia College. A son of this worthy sire was John Kearny Rodgers, who early became a favorite pupil of that skillful and renowned surgeon, Dr. Wright Post, the Professor of Anatomy in, and President of the College of Physicians and Surgeons of New York. He was graduated in arts at Princeton College, N.J., in 1811, and in medicine in the College of Physicians and Surgeons of New York in 1816; he was also Demonstrator of Anatomy for his preceptor, house surgeon of the New York Hospital, and for many years surgeon of the same. He visited London in 1817, and became a pupil of the London Eye Infirmary, then lately founded by Dr. J. C. Saunders. It was here that he and the late Dr. Edward Delafield imbibed and formulated those ideas that led to the final establishment of the New York Eye Infirmary in 1820, of MEMOIR OF ABRAM DU BOIS, M. D. 719 which he was the leading Surgeon for more than thirty years. As an oper- ator he was distinguished for ease, dexterity, and skill, and his operation of ligation of the left subclavian artery within the scalenus muscle, for aneurism, in October, 1845, was one of the surgical sensations of the day, and brought honor to him from the surgical world ; it was the crowning glory of his surgical career. He was in an eminent degree truthful in all his habits, a man of sterling integrity, and a bold and earnest advo- cate of conservative surgery, believing most firmly in the truth of John Hunter's remark, that “When the surgeon takes up the knife he lays down his science.” He abhorred quackery in all its forms, both in and out of the profession—hence we find him an early advocate in 1846 of the forma- tion of the New York Academy of Medicine, which was instituted in 1847 by “men good and true” for the expressed purpose of reorganising the medical profession and purifying it from quackery in its various forms. His name leads its list of charter members, as mentioned in that instru- ment, granted by the Legislature of New York in 1851. If alive, there would be no doubt where he would stand to-day—his position would be that advocated so firmly and adhered to so nobly by his worthy pupil, Abram Du Bois. Dr. Du Bois possessed a generous and active philanthropy. He was ever watchful of the needs of the profession, ever ready to extend a gener- ous aid towards supplying means that would advance the good of the pro- fession. When in 1876 the New York Academy of Medicine had, after years of zealous labor, purchased a building and furnished the requisites for a medical home, pledged for the improvement of the profession; and when the rapid growth of the institution caused thereby had extended be- yond the funds and means at its command, Dr. Du Bois, observing the wants of the institution, although not a member, volunteered, unsolicited, gifts which, in the aggregate, amounted to nearly fifteen thousand dollars, and which led to improvements that greatly increased the usefulness of the institution. But these generous gifts served as incentives for further bene- factions, and at the time of the secession of the New York State Medical Society in 1882, he had nearly completed plans for erecting a fire-proof building for the Academy, at his own expense ; and to-day, but for that dis- astrous movement, the institution would have been the better by, at least, One hundred thousand dollars. And now it becomes my duty to speak of Dr. Du Bois’ zeal and labor in helping to found this Association, an institution in which he ever felt a deep and abiding interest. When, in the month of February, 1882, fifty-two medical men, more zealous than wise, severed abruptly the relations of the greater part of the organised profession of the State of New York from affiliation with their brethren of the United States, and when in February, 1883, ninety-five in an aggregate vote of two hundred could not restore the desired affiliation, thereby confirming a great disaster, and bringing disre- pute upon the good name of the profession of this State, Dr. Du Bois, in keeping with his life convictions on the subject of the relations of special- ism to the general practice of medicine, became a member of the Central 720 WEW YORK STATE MEDICAL ASSOCIATION. Council which was formed in this city, and which formulated the plan that led to the final organisation in 1884 of this honorable Association. His wise counsel and his active labors did much to facilitate and hasten the desired results which we here enjoy to-day. He ever watched with an earn- est and appreciative interest the scientific work of this Association, and so long as his health permitted, was present at its annual meetings. At the annual meeting of 1891 the Association passed resolutions of respect to his memory. Dr. Du Bois, we have intimated, was a man of strong convictions, and in the quiet discharge of what he believed to be duty, his courage never failed. He was of a generous and noble nature, ever ready to defend the right with his whole soul, and to extend unseen aid to the needy and un- fortunate of the profession. His benefactions to various objects of public and private charity, and to medical organisations were, during the last eighteen years of his life (and I violate no confidence of the living by de- claring it), more than seventy-five thousand dollars. We have made allusion to his convictions on the relations of specialism to the general practice of medicine. Like Dr. Thomas Addison he dreaded becoming a specialist, for it savored of quackery. He looked upon the in- troduction of specialism, as his keen foresight comprehended its antagonistic propensities to manly relations between the family physician and his par tient, as detrimental to a community of interests, and as most likely to be subversive of the best interests of harmony in the profession. What has the development of its workings in modern times proved ? The answer comes rolling in from over the length and breadth of our land—“the loss of confidence of the community in medical honor, and a gradual and steady diminution of courtesy in professional relations.” These results he pre- dicted with unerring certainty, and with an earnest and commendable zeal he labored with us, until prostrated by his fatal sickness, to diminish, if not prevent, their disastrous effects. MEMOIR OF M. CALVIN WEST, M.D.” BY THOMAS M. FLANDRAU, M. D., ONEIDA COUNTY. Death, always solemn, is rarely more startling and impressive, than when a prominent man...in full health and vigor is suddenly stricken down. The city of Rome was greatly shocked by the announcement on the 20th October last, that Dr. M. Calvin West, the subject of this brief sketch, had been thrown from his carriage and that his life was despaired of. Within thirty-six hours from the occurrence of the accident he was dead. Possess- ing a fine physical development, unusual strength and activity, and almost uninterrupted health, it was difficult to realise that he could not recover, and that his familiar figure was never more to be seen. The ancient and awful admonition of Notker, was again most painfully verified ; “Media wita in morte sum us,” “In the midst of life we are in death.” Dr. West was born in Rome, September 11, 1834. His father, John West, was a successful farmer residing many years in that town. The family was of English extraction, and had early settled in the State of Vermont. The doctor received an academic education and graduated at the age of eighteen. In 1857 he began the study of medicine in Hagers- town, Indiana, with an uncle. Dr. Calvin West took the regular course of instruction at the University of Michigan, at Ann Arbor, and obtained his diploma in 1860. He commenced to practice his profession in Indiana, and was a member of the Wayne County Medical Society of that State, of which organisation he was also President. In 1861 he removed to Floyd, in this county, and in 1863 to Rome, where he resided till his death. He was for many years a member of the Oneida County Medical Society, of the New York State Medical Association, of the New York State Medical Society, and was a permanent member of the American Medical Associa- tion. In 1861 Dr. West was united in marriage to Miss Felicia H. Williams. She and their four children survive him. Possessing a mind of excellent power, a quick and clear judgment, great energy, and an agreeable address, he rapidly advanced to the front rank of his profession, and to his death held a large practice, extending through many of the northern towns of this county. There are few physicians who possess more completely the confidence of their patients than he did, and few Will be more widely missed or more sincerely mourned. His activity and Capacity for affairs led him into many business enterprises. He was long a director in the Central National Bank of Rome, and a stockholder in Rome's Various manufactories. He was ever ready to contribute liberally to what- ever would forward the progress of the city. For several years he was a 1 Read at the meeting of the First District Branch, July, 1892. 722 MEW YORK STATE MEDICAL ASSOCIATION. member of the Board of Education of Rome, and was for ten years physi- cian to Oneida County Almshouse and Asylum, but though strong in his political convictions, which were those of the Democratic party, he was not an aspirant for elective office. The laborious character of the practice of medicine in the country and smaller cities leaves little time for literary pursuits, and it was only in early life that he was able to write on professional subjects or read papers before medical societies. An article on “Hypodermic Injections,” of much prac- tical merit, was published by him in the Cincinnati Lancet. I do not know of any late contributions to the journals. If not a frequent writer, he was always well read in the literature of medicine, keeping fully abreast of the times; and while not willing to abandon the established results of the experience of the past, was ready to accept and apply the discoveries of the present, which with wonderful originality add continually to the science of disease and to the armamentarium for its cure. In his intercourse with the profession, Dr. West was always frank and courteous, and the many members of it, who have come in contact with him in consultation, will testify to the honorable treatment received from him. Strong in all his convictions, he was strong in his faith in the prin- ciples and doctrines of the regular faculty, having no tendency to any form of empiricism. Deeply must all regret that one so capable by culture and long experience of doing good to his fellow-men could be taken away in the full development and fruitage of a successful career. We can only explain such mysteries by a reference to that highest power, who con- trols every incident of the Universe. MEMOIR OF MYRON N. BABCOCK, M. D. 1 BY T. B. REYNOLDs, M. D., OF SARATOGA COUNTY. MR. PRESIDENT AND GENTLEMEN OF THE ASSOCIATION : It becomes my melancholy duty at this time to communicate the fact that since our last gathering, death, the inevitable, has penned to the ever-increasing necro- logical record the name of a distinguished brother, one who will be greatly missed by the profession in general, and his many friends in particular. He was one of the most prominent and influential founders of the New York State Medical Association, of which this Second District Association is a part or branch. Dr. Myron N. Babcock passed away quietly, peacefully, and contentedly at his Ballston avenue residence in Saratoga Springs, Saturday, May 21, 1892. It was the sunset of his useful life, and the chapter of his existence closed while the day was merging into night; and as the curtain of gloom was lowering about the household, there were gathered about him ministering loved ones—wife, son and daughter. For about two years he had not enjoyed good health, but still he continued his professional duties, and it was not until a few weeks previous to his demise that his con- dition became serious and he realised that the beginning of the end was not far distant. He was a most heroic sufferer, and without a murmur pat- iently awaited the result—dissolution. Eminent as both physician and surgeon, his many years spanned an active life, and his memory, like the many beautiful floral emblems of springtime, when he took his departure, will always be fragrant with the many deeds so kindly, generously and unostentatiously performed by him. Dr. Babcock was the oldest practis- ing physician of the village, which for more than fifty years had been hon- Ored by his cheerful presence, valued counsel and skilled attention. Oc- cupying a dignified and praiseworthy position at the head of the profession he so faithfully and devotedly honored, he furnished a shining example, and one that commands both our admiration and commendation. Dr. Babcock possessed an exalted nobility of character, sterling integrity, strong convictions and generous impulses. The younger members of the profession always found him a wise counsellor and most devoted friend and brother, ever prompt to assist. They, with others, will cherish his mem- Ory. Dr. Babcock was born in West Berkshire, Vt., in 1819. He studied medi- cine at Vermont Medical College in that State, and was admitted to prac- tice. Subsequently he resumed his studies in New York city, where he practiced for a brief period. Afterwards he located in Schuylerville, where 1 Read at the meeting of the Second District Branch, 1892. 46 724 JNE W YORK STATE MEDICAL ASSOCIATION. he remained only a short time. In 1853 he made Saratoga Springs his home, and was for many years associated with the late Dr. R. L. Allen, the firm name being Allen & Babcock. Dr. Babcock leaves a widow, whose maiden name was Blanche W. Shaw, and two children, Dudley C., and Grace S. Babcock. The funeral took place from the family residence on the Tuesday following the demise. Rev. Dr. Alexander Proudfit officiated. MEMOIR OF LUCIEN DAMAIN WILLE, M.D.” BY AUSTIN FLINT, M. D., OF NEW YORK COUNTY. “LUCIEN ANTOINE DAMAINVILLE was born in Erie, Pennsylvania, November 27, 1839. He died December 15, 1891, at the age of fifty-two years and eighteen days. A pupil of the Collège Louis-le-Grand, he was always among the first in his class, and almost always took the first prizes. “At the age of fourteen years it was thought to make an artist of him on account of his taste for music. With this intention he was made to enter the Conservatoire de Paris. His father, fearing for him this career, decided that he would return to America, and he finished his education, already quite advanced. At the age of seventeen years he was sent to Dr. Hamil- ton, under whose direction he studied medicine. He accompanied him to New York and passed his examinations brilliantly in Brooklyn, where he received his diploma of Doctor of Medicine. He always assisted Dr. Hamilton in his operations and in his lectures in Brooklyn, and finally went as his assistant-surgeon to the War of Secession. “His Character.—His uncle says that he always did him honor, and that he never had a reproach to make to him ; that he never regretted an hour, even five minutes that he had charge of him. Dr. Hamilton said to his father (who asked him what he thought of Lucien) that he had taught many young men in his life, but that few had been so intelligent and had given him so much satisfaction. “This is all I have to say about my poor child.” I have translated literally this touching memorandum received from the aged mother of the late Dr. Damainville, whose sole dependence he was. Dr. Damainville was never married, perhaps for the reason that he felt it his duty to devote his life to the care of his mother and sister. I write this brief memoir with more than ordinary feelings of friendship for its subject. In the fall of 1858, Dr. Damainville, then a young medical student, assisted me at the first lecture I ever gave. He continued to act as my assistant during the session of 1858–59 at the Medical Department of the University of Buffalo. In 1860 he was graduated in medicine at the Long Island College Hospital. The records of the War Department show that he was mustered in as an assistant-surgeon, New York Volunteers, June 18, 1861, and as surgeon, November 27, 1862. He was mustered out, June 4, 1863, after service in the Sixth Corps, Army of the Potomac. He Was again mustered in as assistant-surgeon, Second New York Veteran Cavalry, November 9, 1863, and as Surgeon, August 10, 1864. After serv- ice in Mississippi and Louisiana, he was finally mustered out, November 8, 1865. After his discharge from military service, Dr. Damainville began practice in the city of New York, and acted as assistant to Dr. Frank H. Hamilton. He was for many years one of the surgeons of the French * Read at the Eighth Annual Meeting of the Fifth District Branch, May 24, 1892. 726 JWEW YORK STATE MEDIOAL ASSOCIATION. Hospital of the City of New York, and recently one of the attending sur- geons to the Class of Genito-Urinary Surgery, Bureau of Medical and Sur- gical Relief for Out-door Poor, Bellevue Hospital. He was appointed police surgeon, New York city, in 1885, and assigned to the Thirty-third and Thirty-fourth Precincts. On the retirement of Dr. Varian he was transferred to the Thirty-second and Thirty-fifth Precincts. He removed to Kingsbridge and became associated in practice with Dr. Varian in the spring of 1890. Dr. Varian writes me that, “He made many friends in his district, and was accumulating a large practice about him, and if he had been spared a few years would have had one of the most lucrative practices in this city.” The duties of Dr. Damainville as a police surgeon involved much labor and exposure, often in severe weather. After an unusually hard day's work, when he had been for many hours exposed to cold and wet, he had a severe chill, followed by a circumscribed pneumonia, with low delirium. After a few days he improved considerably, but without much diminution in temperature. The characteristic appearance of typhoid fever afterward became developed, and he died of exhaustion, December 15, 1891. Dr. Damainville was endowed with an eminently artistic temperament, which probably interferred somewhat with his success as a practitioner. He was not only an accomplished violin virtuoso, with a purity and volume of tone, as well as technique, which would have given him a high rank as a professional performer, but a perfect reader and a thorough musician. In- deed, in his early struggles in New York, he supplemented his professional income by giving lessons to orchestral players and occasionally performed at public concerts. He was so jealous, however, of his status as a phy- sician, that he concealed his work as a musical performer and teacher, and never appeared as such in this city. His exquisite musical organisation and accomplishments, with tastes more or less Bohemian, in the best sense of the term, led him to seek the Society of artists, and he enjoyed the ac- quaintance of our best resident and visiting musicians, especially Vieux- temps, with whom he was on terms of close friendship. With such tastes and acquirements, it must often have been difficult for him to forego artistic reunions for the dry work of ordinary practice. Dr. Damainville contributed little to professional literature. Educated in France, he never acquired complete command of the English language. Nevertheless, he was a good practitioner, a careful, self-reliant and skillful surgeon, and devoted to his profession. At an age when most men of his ability and experience should have long since passed the struggles and dis- couragements of professional life, he was on the threshhold of material Suc- cess, and was building up a lucrative practice when he was taken away in the full enjoyment of health and strength. He had just sent his mother to visit her native land, which she had not seen for more than half a century, thus realising for her the dearest wish of her declining years. It is a melancholy satisfaction to pay this small tribute to one Whose professional career I have followed from the first ; an honorable physician, a good son, a charming companion, a true and devoted friend. MEMOIR OF NATHANIEL CLARK HUSTED, M. D. BY RICHARD B. COUTANT, M. D., OF WESTCHESTER COUNTY. Born October 22, 1825. Died November 19, 1891. The time intervening between these dates measures the mortal existence of our former associate, NATHANIEL CLARK HUSTED, whose memory we are assembled to honor and to receive honor from. The character of a man's life is determined by his inborn qualities and inclinations, modified by the purposes and habits which have been de- veloped by education and environment. In the life that we are about to consider there was a happy blending of those forces, resulting in a well-poised organisation, which fitted its pos- sessor for earnest, skillful, sustained work, and made him through his mental activity and his integrity a leader among men. The Husted, or Hustis family, as the name is sometimes written, was of Dutch origin, and some of its members were among the first settlers of Connecticut. Robert A. Husted witnessed the deed which conveyed the present towns of Stamford and Greenwich from their native owners to the white pioneers of 1640, just twenty-five years after the discovery of that part of the continent. In another instrument, executed about the same time, the name of Angell Husted appears for a similar purpose. These men acted with authority from the New Haven Colony, and were distinguished personages in the early history of New England. Thirty years later Angell Husted was one of the twenty-seven proprietors of this region, and the name has been a prominent one in the annals of Greenwich and its vicinity from that time to the present. Among recent representative members of the family may be mentioned Jabez W. Hustis, of Westchester, one of the trustees of the University of the City of New York; James W. Husted, of Peekskill, whose ability is too well known to require comment ; John A. Husted, for years an attorney and counsellor-at-law at Tarrytown, N. Y.; Nathaniel W. Husted, lately one of the leading business men of the same place; Jarvis P. Husted, M.D., of New York city; Nehemiah Husted, a prosperous farmer and a selectman of Greenwich, Conn.; Harvey P. Husted, of White Plains, stenographer to the Westchester County Court; and Nathaniel Clark Husted, the subject of this sketch. The characteristics of the Husted family are a close-grained, fine-fibered Organisation, fitted for persistence and endurance, making its members by nature capable, self-reliant and painstaking men and women of good habits, industry, and thrift, whose faults are mainly exaggerations of their natural endowments. Dr. Husted boasted of a double line of descent from this 728 NEW YORK STATE MEDIOAL ASSOCIATION, stock, his father being Nathaniel Husted, the son of a revolutionary soldier of the same name, and his mother, Mary E., daughter of Amos Husted. His career, as we shall see, exemplified the family traits and did ample credit to his origin. . N. C. Husted was born in the family homestead at Round Hill, Fair- field County, Conn. He was the second of a family of six children, four of whom, Jarvis N., Emily, Sarah Griffin and Ruth Knapp still survive. During the first twelve years of his life young Husted was inclined to be delicate, having suffered from the various diseases of childhood in a severe form. On this account he was excused from manual labor and from regu- lar attendance at school. As his feebleness of body did not encourage him to indulge in sports requiring activity and strength, he acquired a fond- ness for books, and laid the foundation of a taste for literature which in- creased with his age, and was the chief solace of his later years. At the age of thirteen he was put steadily at school, where he began the study of the classics. In his fifteenth year he was placed under the care of the Rev. Chauncey Wilcox, at Quaker Ridge, in his native town. This gentleman was an accomplished scholar and teacher, and a man of excellent character as well, who considered it his duty to instil into the minds of his pupils the principles of moralty as well as of scholarship. Dr. Husted always spoke of him with affectionate regard, and ascribed to him the awakening of the aspirations which led to his advancement in life. At the early age of seventeen he was prepared to enter college, but the money necessary to defray his expenses was lacking, and he determined to earn it by teach- ing school. At this period he was very frail, and being harassed by a severe cough, the future did not seem very bright to him, and his friends expected his rapid decline. His first engagement was at North Castle, N. Y., where he became intimately acquainted with Dr. Mackay, in whose family he boarded. The doctor took a warm interest in the young peda- gogue, cured him of his cough, and undoubtedly spoiled his college career by encouraging him to study medicine. After a year and a half of hard work at North Castle, he was induced to open a select school at Stanwich, Conn. Having made this a success, he disposed of it to other parties and returned to North Castle for another year, after which he wended his way to the village of Rye, where he taught for six months. During this en- gagement he registered himself as a student in medicine with Dr. Sands, of Portchester. His next school was at Colaburg, now Croton Station, on the Hudson, where for six months he continued his reading with Dr. Caleb W. Haight. In the summer of 1848 he gave up teaching, and located in Pleasantville, where he devoted his entire time to the study of his profes- sion under the same preceptorship. In the Fall of this year he matriculated at the Medical Department of the University of the City of New York, and came under the personal influence of such men as Valentine Mott, Granville S. Pattison, Samuel H. Dickson, John W. Draper, Martin Paine and Gunning S. Bedford. At the close of the session Dr. Haight obtained a position for his student at the Westchester County Alms House, where his duties combined the functions of resident physician and head nurse. This term of service MEMOIR OF NATHANIEL CLARK HUSTED, M. D. 729 proved to be one of the most eventful periods of his life. Ship fever was epidemic at the time, and nearly two hundred cases occurred in the institu- tion to mark its ravages. At a time when the young interne was thor- oughly exhausted by attention to his duties, he succumbed to the disease, and for weeks his recovery seemed impossible. Thanks, however, to the skill and care of Dr. Haight and the other visiting physicians, he finally began to Inend, and later in life dated his permanent improvement in health from this illness. No sooner had this epidemic subsided than cholera made its appearance, causing a number of deaths; and in the Fall, smallpox broke out and spread rapidly among the inmates. In October, feeling much richer in practical knowledge of disease, he renewed his rela- tions with the University, and on the 8th of March, 1850, received his de- gree of “Doctor of Medicine.” In April he opened an office at 353 Sixth Avenue, having scarcely money enough to pay for his sign, and neither books, instruments nor apparatus to aid him in his work. He found a boarding place near his office with Wm. B. Riker, the well-known drug- gist, who showed his appreciation of his lodger's talent and pluck to such a degree, that, coupled with his own exertions, he felt it prudent, so great had been his success, to marry when a year had passed. Dr. Husted was now twenty-six years of age. He had by his earnest endeavors overcome many of the disadvantages of his youth, and Saw before him the certainty of success in his calling. For over a year he had been engaged to Miss Mary J. Palmer, of New York city, and we can easily fancy his joy as he contemplated the step he was about to take, marking as it did his advance in happiness as well as in prosperity. They were mar- ried as he had planned, but alas for huſman hopes, ere a year had passed he laid his wife and new-born child in a single grave, and returned to his desolate home to begin life over again, broken in spirit and thoroughly un- fitted for the duties he had to perform. Rallying from his depression by degrees under the stimulus of enforced Work, he devoted himself more earnestly than ever before to the science as well as to the art of his calling, and came to be so favorably known in the district in which he lived that he was considered the leading practitioner there, and began to be well known outside of its limits. As his life broad- ened and his burdens multiplied, he felt more and more in need of com- panionship and of the comforts of a home, and when a suitable time had elapsed he was married to Miss Deborah Fairchild, the daughter of Benja- min P. Fairchild, Esq., of New York city, who survives her husband, hav- ing proved the wisdom of his choice by nearly forty years' devotion to his interests. - For two years after his marriage Dr. Husted resided near his Sixth Avenue office, but in 1855, yielding to the solicitations of many influential patrons, he moved to Forty-second Street between Eighth and Ninth Avenues, and opened an office there. For the next ten years he devoted his entire time and energy to the practice of his profession, with the most fortunate results, becoming as well and as favorably known to the profes- Sion of the city as he was among the laity. He associated himself with all 730 NEW YORK STATE MEDICAL ASSOCIATION. the leading medical societies of the city and of the State, and was promi- nent famong those who took an active part in their proceedings. In 1862 he volunteered for surgical service in the United States Army hospitals, and was sent by the Surgeon-General of the State to Fortress Monroe, where he spent several weeks in company with Drs. Willard Parker, J. R. Wood, Stephen Smith, A. C. Post, T. M. Markoe, Alden March, Robert Watts and others from New York State, ministering to the wounded brought there from the battlefields of Virginia. In 1866 Dr. Husted’s father and mother, who had continued to reside upon the old homestead at Greenwich, died within a week of each other after brief illnesses, and the shock, coupled with the effect of his over- doing, enforced him to retire temporarily from work. A little before his parents' death he had taken Drs. White and Dumond, who had passed the period of their pupilage in his office, as his assistants, and relinquishing his practice into their hands, he removed to the country for rest and recrea- tion. His purpose was to give up work for a year, but he returned to the city before the vacation he had planned had expired, and with Dr. Charles Bliss as his associate he opened an office in Fifty-first Street, and remained there until his old office was vacated at the end of the year. In April, 1871, he removed to West Fifty-sixth Street, and in the following month entered into equal partnership with Dr. Bliss, with whom he remained as- sociated until the Spring of 1878, when on account of permanent failure of health he retired from metropolitan practice and established himself at Tarrytown. Diabetes mellitus, the disease from which he was suffering, had been diagnosed by himself in November, 1877, and for a year his de- cline was so rapid that his case was pronounced hopeless by the best authorities, and he had constantly before him the expectation of speedy death. Failing to secure relief from the treatment of the disease in vogue at the time, the doctor began experimenting himself, and finally discovered a combination of remedies which in connection with a rigid diet produced an improvement in his symptoms, and eventually freed him from the dire effects of his disease. As soon as he began to mend his old activity reas- serted itself, and in a short time he established a large office practice, mak- ing something of a specialty of diabetes and renal diseases, and before he realised the consequences, he was again absorbed in general practice and working with his old-time energy and success. The wide circle of his pro- fessional acquaintance caused him to be called long distances in consultation and to perform operations, and patients often came to his office from points fifty miles away. In addition, he visited his office in the city once or twice a week, where his old-time friends thronged about him and availed them- selves of his counsel, years after they had ceased to employ him at their homes. On Thanksgiving Day, 1878, the Semi-Centennial of the Methodist Episcopal Church at Round Hill, Conn., was celebrated, and Dr. Husted, whose ancestors were largely instrumental in establishing it, delivered the historical address, and afterward prepared the volume published by the church in commemoration of the affair. MEMOIR OF NATHANIEL CLARK HUSTED, M. D. 731 At the meeting of the New York State Medical Society, held at Albany in February, 1879, Dr. Husted was elected vice-president of the Society, and read a paper on diabetes, which was favorably received. A fortnight later he read a similar paper before the Westchester County Medical So- ciety, at Sing Sing, and was given a place upon the list of honorary mem- bers of the Society. In July of this year he revived the memories of his youth by attending the convention of the New York State Teachers' Asso- ciation, held at Penn Yan, and was made a member of the same. In the Fall he was made President of the Board of Health of Tarrytown, and was elected one of the trustees of the Westchester County Historical Society. About the same time he began to take an interest in the affairs of the Syra- cuse University, and later he was made a member of its Board of Managers. In June, 1880, he received the honorary degree of M. A. from the Wes- leyan University at Middletown. Early in the summer of 1880, Dr. Husted became interested in the pro- posed celebration of the capture of Major André. at Tarrytown. He was made corresponding secretary of the organisation, and the wonderful suc- cess of the affair was largely due to his untiring efforts. The United States Government and the State were represented, and over sixty thousand peo- ple attended the exercises. The preparation of the volume relating to the celebration devolved upon the corresponding secretary, and he made it one of the best of the many records of such affairs published at the time. In July, 1881, the doctor visited Europe as a delegate from the Ameri- can Medical Association to the International Medical Congress held in Lon- don, and embraced the opportunity of making himself familiar with as much of foreign life and scenery as the limited time at his disposal would allow. On January 1st, 1883, thirty-four years after his first term of service in that institution, Dr. Husted was appointed one of the visiting physicians to the Westchester County Alms House, and continued to be a member of its medical staff until the time of his death. The work engaged in there Was greatly to his liking, as it constantly reminded him of his younger days and their associations, and at the same time brought him into contact with a class whose misfortunes awakened his warmest sympathy, and whose necessities called forth his highest skill. In April of the same year his only daughter was married to Dr. Frank E. Russell, of New York city, a young man of fine promise in his profes- Sion, whom he welcomed into his family with the same affection that he Would have bestowed upon a son had one been born to him. In June, 1884, the Faculty of Syracuse University bestowed upon Dr. Husted the honorary degree of LL.D., in recognition of his scholarly attain- ments and of his valuable services to the institution as one of its trustees. For several years a growing conviction of the uncertainty of the pres- ent life and of the desirability of preparing for the life to come, had dis- turbed the doctor's somewhat materialistic views, and finally turned him to * Saving faith in Christ. On February 1st, 1885, he united with the Methodist Episcopal Church at Tarrytown, and the same evening noted in 732 JNEW YORK STATE MEDIOAL ASSOCIATION. his journal, “The happiest day of my life.” Very naturally, in his new found joy, Dr. Husted's thoughts turned to the place where his forefathers worshipped, and for years the Methodist Church at Round Hill was a place of pilgrimage to him and an object of his benefactions. His interest there centered in the Sunday-school, and never a Christmas passed that he was not the Santa Claus of the occasion, in spite of bad health or unpleasant Weather. Dr. Husted spent many years in collecting a library of general litera- ture, making his selections according to his own taste, from the old and the new ; caring more for solid reading than for light, and more for the matter of books than for the covers that inclosed them. A wisely selected medical library kept pace with his general one, and whenever he shut his office door upon the world, he had at his command between eight and nine thou- sand books to amuse himself with or to work among. In the Fall of 1886 the United States Government established a Pension Examining Office at Tarrytown, for the convenience of claimants in Rock- land County and along the lines of the Hudson River and Northern Rail- roads. Dr. Husted filled the position of president of the board to the time of his death, a period of five years. The doctor was the warm friend of all honest claimants, but the uncompromising foe of all dishonest ones. It is related that after a certain examination he was beckoned out upon his piazza by a veteran whose disabilities were a myth, and there offered a bribe for a favorable report upon his case. A noise as if the house was fall- ing called the rest of the board to the window in time to see the claimant pick himself up at the bottom of the steps, and limp away followed by the doctor's execrations. After a while it began to be noticed at some of the meetings of the board that the president's interest flagged; that he sat down in the midst of his work, and that he occasionally retired from the room. Later he con- fessed to attacks of neuralgia in the chest, accompanied by feelings of pros- tration. These attacks gradually increased in frequency and severity, until activity became a burden and even rest had no charm. A diagnosis of angina pectoris from imperfect nutrition of the heart, which had been made at an early date, was confirmed by the highest medical authorities, and no hope of cure was entertained. All remedies were tried, and all, with the exception of those which afforded relief at the time of the attack, Were tried in vain and abandoned. As there was no help in repose and there Was diversion in work, the poor sufferer kept about, doing more than he was able to, until the end came quickly and he was translated to a life of more abundant joy. In appearance Dr. Husted was somewhat under medium height, but he was deep-chested and broad-shouldered, and gave an impression of great vital force if not of muscular strength. His head was large, the broW being high and wide, and his cranial capacity was much greater than the average. The expression of his face was kind but strong. His manner was genial, and he was inclined to sociability, easily winning the friend- ship and confidence of his patients. In matters of difference he W88 MEMOIR OF NATHANIEL CLARK HUSTED, M. D. 733 unyielding, and equally tenacious of purpose, allowing no obstacle to thwart him that perseverance could overcome. His every instinct was honest, and all his intentions were good. Man-like, his convictions were some times at fault, but this was due to imperfect judgment, not to perversity, and when convinced of error he was always ready to make amends. Dr. Husted was domestic in his habits, preferring his home and the compan- ionship of his family, his library, and a few chosen friends, to anything that society could give. The following lines of Shelley, found inscribed in one of his books, give a key to his taste in this particular: “I love tranquil solitude, And such society As is quiet, wise and good.” Being of a studious habit Dr. Husted was well read in his profession, and was alive to all its improvements, fertile in resources, prompt in action, thoroughly to be depended upon. His knowledge of practical therapeutics was something marvelous, so accurately could he apply a remedy from his vast armamentarium to the relief of a particular symptom or disease. His skill in surgery was greater than that of most all-round practitioners, and during his career he performed a majority of the opera- tions of general surgery, and many others requiring special knowledge and skill. Obstetrics, however, was his favorite branch of practice, and in his days of activity he performed every operation known to it, from Caesarean section down. A forceps of his invention possesses many ad- mirable features, particularly an exaggeration of the pelvic curve to facil- itate delivery at the superior strait. Dr. Husted's studies extended beyond the lines of medicine, and he was Well informed in literature and in science. History had a particular fas- cination for him, and books relating to it were his delight. Being absorbed in active work he found but little time to write, but in addition to the vol- umes and papers referred to above, he read essays before the United States Hay Fever Association, the Microscopical Society of New York, and the New York State Medical Society, and contributed reports of cases to vari- ous medical journals. The office of a practitioner of marked ability has always an attraction for students of medicine, and Dr. Husted's was no exception to the rule. He acted as preceptor to the following physicians: Drs. J. C. Dumond, Edward White, G. Frazer, James Sullivan and Warren Chapin, of New York City; Dr. W. A. Miner, of Sing Sing, and Dr. C. P. Freeland, of Kansas. Dr. Husted was a member of and in many cases served as an officer in the following societies: The American Medical Association, the New York State Medical Society, the New York State Medical Association, of which he was one of the founders; the New York County Medical Society, the New York Academy of Medicine, the United States Sanitary Association, New York Gynaecological Society, New York Obstetrical Society, New York Pathological Society, New York Microscopical Society, Connecticut 734 NEW YORK STATE MEDICAL ASSOCIATION. State Medical Society, Westchester County Medical Society, New York Historical Society, Tarrytown Historical Society, Monument Association of the Capture of André, the New York Statistical Society, and the United States Hay Fever Association. To the very few who knew Dr. Husted intimately he unfolded a rich- ness of nature totally unknown to the outside world, betraying suscepti- bilities and emotions, and sometimes a gayety, even, which, added to his more solid attributes, made him a most charming companion and a model friend. To those few his individuality was unique, and his place can never be filled. - MEMOIR OF JAMES FERGUSON, M. D. BY G. R. MARTINE, M. D., OF WARREN COUNTY. DIED of paralysis, October 27, 1892, at his home in Glens Falls, N. Y., Dr. James Ferguson, aged seventy-four years. He was born in Kortright, Delaware County, N. Y., in 1818, and was graduated from the Medical College in Castleton, Vermont, in 1841. He commenced practice in North Blenheim, but removed to Glens Falls in 1852, where he continued his practice until disabled by sickness shortly previous to his death. He was married at North Blenheim to Miss Cornelia Hager in 1843. His wife still survives him. Of two children, Walter J., and Margaret E., the latter is still living. Walter J. died a few years since. Dr. Ferguson was a man of fine physique, of well balanced mind, of unostentatious, but kindly sympathies. As a physician he was sound in judgment, careful and attentive in practice, never giving needless pain by words or remedies. His medical labors extended over a wide field, marked by success, proving his life one eminently useful to the community in which he lived. MEMOIR OF WILLIAM CHACE, M. D. BY THos. D. STRONG, M.D., OF CHAUTAUQUA COUNTY. HE was born January 4, 1833, at St. Catharine's, Canada, where he ob- tained his literary education. In 1858 he graduated at the College of Physicians and Surgeons, New York City, and at once commenced his practice at Mayville, Chautauqua connty, N. Y., where he spent the re- mainder of his life, engaged in active medical work. Early he took a prominent place in his profession, and year by year rose in the esteem of his brother practitioners, occupying a most desirable position among the best medical men in Chautauqua county. In all emergencies he was a power, and his level head and steady hand never failed him. Towards the profession his bearing was always high toned and honorable. With disgust he looked upon all unprofessional ways. Self-sacrifice in behalf of his patients and friends was a marked charac- teristic, and especially to the poor was he faithful. Though under a severe attack of influenza, he visited in the evening a patient for whom he was anxious, and the next day, December 27, 1891, he died of heart failure. His practice was large and remunerative. He leaves a wife and four sons—the eldest of whom, Wm. C. Chace, is a practicing physician in Buffalo, N. Y. He was a vestryman in the Episcopal church. His social qualities surrounded him with a large circle of friends, who, with his brother physicians, most heartily unite with his family in mourning his loss. He was a founder of New York State Medical Association. REPORTS OF THE DISTRICT BRANCHES. FIRST DISTRICT BRANCEI. THE eighth annual meeting of the First District Branch was held at Stanwix Hall, Rome, on Wednesday, July 20, 1892. The meeting was called to order by the President, W. D. Garlock, M.D., at 11.30 A. M. - There were present fifteen Fellows and three invited guests. The minutes of the last meeting were read and approved. The Treasurer then read his report, showing a balance of $5.00 from last year, disbursements of $6.00, and a collection of $12.00 at this meet- ing, leaving a balance of $11.00 in the treasury at present. The report was accepted and adopted. Dr. W. H. Robb presented a case of multiple cerebral sclerosis, which was examined and commented upon by several. The President then read an address on general medicine, which was listened to with manifest interest. Dr. E. D. Ferguson then spoke of the difficulties of operations in old and large non-reducible umbilical herniae, and gave some experience in renal Surgery, with specimens. Dr. Douglas Ayres read a paper on “Puerperal Eclampsia.” Dr. W. H. Robb then read a paper on “The Use of Electricity, as Ex- emplified in a certain case of Uterine Fibroid.” This was followed by a paper by Dr. J. B. Harvie, on Endometritis, in which he advocated thorough curetting after dilatation. Drainage he did not consider essential. The Secretary then read a paper on “Typhoid Fever; its Causation and Therapeutical Management.” Dr. T. M. Flandrau presented a Memoir of Dr. M. Calvin West, which Was referred to the State Association for publication in the Transactions. On motion it was decided to hold the next annual meeting at Little Falls, in the month of July, 1893, the day to be determined by the Presi- dent and Secretary. The present secretary and Executive Committee were then continued for another year. - W. D. GARLOCK, President. EZRA GRAVES, Secretary. SECOND DISTRICT BRANCH. THE Second District Branch of the New York State Medical Association met pursuant to call at Schenectady, June 23, 1892, for its eighth annual meeting. The meeting was called to order by the President, Dr. McDonald. Twenty-five members were in attendance. The minutes of the last annual meeting were read and approved. The Secretary spoke of an error he had made in the printed programme of the meeting, in which the title of a paper to be presented by Dr. W. W. Seymour had been omitted. Dr. Van Zandt read the report of the Committee of Arrangements, which was received and adopted. Dr. Seymour was given permission to present his papers first, as he was obliged to return to Troy in answer to a telegram. He accordingly read a report of “A Successful Case of Total Extirpation of the Womb for Cancer,” and a paper on “Trendelenburg's Posture in Abdominal and Pelvic Surgery,” with report of cases and exhibition of apparatus. - After the discussion on these papers, the President, Dr. McDonald, read a paper entitled, “The Diagnostic Aid of Anaesthesia in Fractures and Dislocations.” Dr. Hodgman, of Saratoga, presented a report of a case of appendicitis, in which an operation was performed, the appendix removed, and the patient died in a few hours. A post-mortem examination revealed no obstruction of the intestine, death being due to shock occasioned by rupture of the abcess. Dr. T. B. Reynolds reported the death of Myron N. Babcock, one of the founders of the Association, and moved the appointment of a committee to draft suitable resolutions. The President appointed as such committee Drs. T. B. Reynolds, W. H. Hodgman, G. F. Comstock, W. E. Swan, of Saratoga Springs, and Dr. I. G. Johnson, of Greenfield, who subsequently reported the following which was adopted unanimously : WHEREAs, Death has inscribed upon the necrological roll of our associa- tion, the name of one of its most distinguished members, Dr. Myron N. Babcock, who passed away at his Saratoga Springs home Saturday evening, May 21, 1892, and who was one of the founders of the New York State Medical Association, of which this Second District Association is an auxiliary; therefore, be it ReSolved, That this Association take this means of paying tribute to the exalted memory of one whose record as a physician covered over half a PROCEEDINGS SECOND DISTRIOT BRANCH, 739 century, and during the better portion of his active and useful life stood at the head of the profession in the village that was honored by his presence; and Resolved, That this Association also points with pride to the fact that our departed brother possessed preeminent ability in the broad field in which he had been such an active worker, and that he was a shining example to the profession which he adorned, and that he was always ready and willing to counsel and assist his younger medical brethren. Resolved, That by his sterling integrity, nobility of character, generous impulses and other eminent characteristics, as well as his devotion as a husband, father, and a citizen, the memory of the departed reflects great credit on the Association, the members of which unite in extending words of condolence to the family in their bereavement. Resolved, That the above preamble and resolutions be given to the press for publication. The next paper was by Dr. H. E. Mitchell, and was entitled, “Why Oculists Should Treat Nasal Diseases.” Dr. J. P. Marsh then read a paper entitled, “Haemorrhage from the Normally Implanted Placenta.” Dr. J. B. Harris then read a paper with the title, “Endometritis, with Treatment by Curetting and Washing out the Cavity.” The next paper was by Dr. Ferguson, on “Some Recent Kidney Sur- gery,” with a report of two cases, and the presentation of post-mortem specimens, one being a “horseshoe” kidney. Dr. S. W. Houston reported a case of Hydramnois. On motion, the Executive Committee was retained another year. The thanks of the Association were voted the Local Committee for their successful efforts for the entertainment of those attending the meeting. Resolved, That when the meeting adjourn it be to meet at Saratoga, June 22, 1893. Adjourned. GEO. E. McDONALD, President. CHARLES H. BURBECK, Secretary. 47 THIRD DISTRICT BRANCEI. The eighth annual meeting of the Third District Branch, N. Y. S. M. ASSociation, was held in Owego, at Ahwaga Hall, June 16, 1892. In the absence of the President, the meeting was called to order at 10:30 A. M. by the Secretary. Dr. J. G. Orton was called to the chair, and presided over the meeting until the arrival at noon of the President, Dr. L. J. Brooks. The following members registered : W. L. Ayer, Ely Van de Warker, Leroy J. Brooks, F. W. Higgins, J. G. Orton, Dwight Dudley, of Maine, Broome County; R. A. Seymour, H. C. Rogers, John E. Beers, L. H. Hills, George M. Cady, F. W. Ross, C. W. Greene, C. L. Squires, Elias Lester, William Fitch, J. H. Chittenden, E. Lester, F. G. Seaman. New members: C. L. Stiles, Owego ; A. J. Harris, Camlor; George B. Lewis, Owego, all of Tioga County. The following invited guests were present : Drs. Morrow, of Warren; Glover, Knapp and Burr, of Newark Walley; Barrett and Lounsbery, of Owego ; Brown, of Elmira; Chittenden, of Allison; and Bassett, of Bing- hamton. The President appointed the following Nominating Committee : L. H. Hills, Binghamton; F. W. Ross, Elmira; H. O. Jewett, Cortland; F. G. Seaman, Seneca Falls; George M. Cady, Nichols; William Fitch, Dryden. The Nominating Committee reported, through its chairman, L. H. Hills, that they would recommend the next annual meeting to be held in Elmira; that Dr. C. L. Squires be made Secretary, and that the following gentlemen constitute the Executive Committee : H. C. Rogers, Bingham- ton; W. R. Laird, Auburn; F. W. Ross, Elmira; F. W. Higgins, Cort- land; W. B. Morrow, Walton ; F. O. Donohue, Syracuse; J. J. Sweet, |Unadilla; H. C. Lyman, Sherburn; B. T. Smelzer, Havana; Elias Lester, Seneca Falls; William Fitch, Dryden; John K. Leaming, Coop- erstown ; M. Cuvana, Oneida. The next order of business was the President's address, but in the absence of that officer the Secretary moved the by-laws as to the order of business be suspended, and at once proceed to the reading of papers. The first paper read was by Dr. F. W. Ross, of which the following is an abstract : CEIRONIC RECURRING APIPENDICITIS, The recent investigations and brilliant operations for the relief and cure of appendicitis have created a new era in the surgery of the digestive tract and its appendages. What the function of this troublesome little rudiment- ary third stomach may be no one has attempted to prove or explain. PROCEEDINGS THIRD DISTRIOT BRAWOBI. 74.1 I believe that all operations for appendicitis should be performed just as soon as the diagnosis is positively made, and there is the least tendency to suppuration or indication of grave trouble at McBurney's point, for the chances are many times in favor of there being a lesion of the appendix— in fact many go so far as to doubt the existence of typhilitis, peri- and para-typhilitis, in the sense in which we formerly understood these terms, and lay most of the blame to the appendix. Here is where all the contro- versy arises. The general practitioner who has had many cases of typhºlitès 8tercoralis which have recovered cannot understand why the surgeon finds so many cases of appendicitis. When there has been a case of what has been considered as a suppurative typhilitis, which has pointed and been opened, or aspirated, and a cure followed, we are not certain that the appendix was not the seat of the mischief. Recent investigations in the pathology of these conditions about the head of the large intestines tend to throw the preponderance of evidence against the appendix, which is the real seat and origin of the trouble. The following is an illustrative C8 Se . J. W. H., merchant, good habits and family history, forty-five years of age, had always been of spare build and Sedentary habits, and was inclined to be constipated. I first saw him in December, 1890, for what I diagnosed at the time as a mild attack of typhilitis. After keeping quiet for two weeks he returned to his business. In August, 1891, he had a severe attack of pain in the right inguinal region, slight elevation of temperature, and a small tumor in the right groin, which was firm, hard and smooth. It gradually disappeared entirely in about six weeks, but he had only been about his business for about two weeks when the trouble returned. He remained quiet two or three weeks, returned to business for four or five weeks, but again had a relapse, characterised by quite sudden pain at McBurney’s point, uneasiness, and a distinct tumor, as before, which was not very tender; there was slight constipation, but no obstruction. The tumor gradually disappeared in about two weeks, only to return suddenly after a week. This was repeated eight or nine times up to April 13, 1892. Hoping against hope for a cessation, and satisfied that at least an explora- tion was necessary, I took him to New York and consulted Dr. W. T. Bull, who advised an exploration, but expressed doubts as to my diagnosis of appendicitis. He thought it might be cancer of the gut ; he had never seen the appendix as low down as in this case. I argued that it could not be a malignant growth and completely and entirely disappear, and so sud- denly return. At the operation, which was in St. Luke's Hospital, an incision was made directly over the tumor, and the caput coli brought to view. The appendix was found enlarged and twisted upon itself, and bound to the omentum and gut by plastic adhesions. The lumen of the tube was obstructed in two places. The tissues, as if erectile in structure, seemed capable of distention, and the bowel, filling with gas from below, Would raise the mass in position, thus forming, through the thin abdom- inal walls, a well marked and easily felt tumor. The appendix was loos- ened from its adhesions and ligated close to the head of the caecum, and 742 NEW YORK STATE MEDICAL ASSOCIATION, the cavity thoroughly sponged out. The wound being thoroughly clean it was immediately and permanently closed. The patient has since re- turned to his home completely recovered. The paper was discussed by Drs. Hills, Jewett, Lester and Higgins. Dr. C. L. Squire, of Elmira, then read a paper on “The Natural His- tory of Diphtheria" (not furnished to the Secretary). Dr. H. C. Rogers read a paper on “Typho-Mania”— The motor agitation, the psychic exaltation, the whole picture of simple acute mania is familiar. Typho-mania, on the other hand, is an unusual brain disease, an acute delirious mania, in which the reductions sink to the most profound depths. If to excessive restlessness, trembling and tottering, persistent sleep- lessness, incessant loquacity, wild delirium, and absolute incoherence of thought and speech—symptoms connoting an acute delirious mania—be superadded, rise of temperature—a symptom found nowhere else in mania —a rapid, feeble, easily compressed pulse ; marked diminution, or even suppression, of urine ; loss of control over the sphincters; prostration, so great that the patient lies helplessly on his back rocking from side to side— we have the clinical outline of typho-mania. In simple acute mania, violent though the storm may be, the brain meets the demands upon it, and eliminates through its vascular system the increased products of tissue metamorphosis. The delicate lymph-connect- ive system, enveloping so intimately the brain cells, remains passive as in health. In tpyho-mania the brain cannot meet the demands upon it. The ceaseless activities of innumerable cells, their tremendous molecular inter- changes, throw more debris into its vascular system than can be eliminated through those channels. The lymphatics spring to the rescue, and, taxed beyond measure, swell with effete products. Herein lies the essential pathology of typho-mania. Typho-mania is overwhelming. Unless immediate relief be at hand, exhaustion and somatic death soon end the scene. As to this relief, with chloral, paraldehyde, and allied drugs, we accomplish something ; perhaps, can Sooth the struggling cells and check the accumulating debris. But this is very doubtful. Moreover, it is not so much the subduing of the vös a tergo, as it is the establishing and main- taining of a free escape for the results of the vis a tergo, which confront us as the main indication; and we accomplish far more by taking up the remedy of one, Dr. Langrode, over whose exploits in Gil Blas, we doubt- less all have laughed—water. With it, in the form of generous colon baths, we stimulate and flush the kidneys, eliminate through them the debris from the lymph-connective system, and let the surcharged brain wash ēt- Self. Under this line of treatment I can bear witness to the most gratifying results. Under it I have seen the psychosis promptly rise to the level of simple mania, and pass off. Dr. L. H. Hills then read a paper on “Insanity in its relation to crime,” but no copy was furnished. Dr. E. Van de Warker then read an instructive and practical paper on PROCEEDINGS THIRD DISTRIOT BRANCEI. 743 “Chronic Uterine and Pelvic Pain,” and treated the subject from a thera- peutical standpoint. By invitation, D. M. Totman, of Syracuse, read a report of a case of double osteotomy for correction of deformity resulting from Colles' fracture. Also by invitation, Dr. E. G. Drake, of Elmira, read a paper on “A Study on the Identity of Diphtheria, Membranous Croup and Follicular Tonsillitis ‘’— Evidence of a fixed law upon the question of identity or non-identity in the diseases, diphtheria, membranous croup and follicular tonsillitis does not appear to stand out conspicuously in the pages of our modern, or moderately ancient history. Contributors of eminence, of enviable position in the medical world, are numerous, and theories likewise, both for and against the question, but it is a striking, a singular, and a significant fact, that those who believe them to be one and the same disease, with a variety of manifestations, provide time, space and special classification for them under distinct and separate titles. After quoting the opinions of many well recognised authorities, the writer continued : Many of the older members of the profession, who had abundant oppor- tunities for studying the membranous croup when diphtheria was unknown and where it did not exist, recognised the clinical and pathological differ- ences between the two affections. From 1775 to 1850 the cases of mem- branous croup occurring in this country, as well as Great Britain, were local in character, the lesions being confined for the most part to the upper air passages, and causing death by suffocation. Septic symptoms were not observed, nor did the disease appear to be contagious. Diphtheria was quite unknown, and many practitioners with large opportunities for obser- vation never saw a case of the disease. The record of mortality from croup and diphtheria in Philadelphia during the past forty years is both interesting and instructive. From 1846 to 1859 the annual mortality from croup varied from 111 to 312. No deaths from diphtheria during that period were recorded. From 1860 to 1879 the annual death rate from croup ranged from 185 to 455, while that from diphtheria was from 110 to 708. Is it possible that the 3,078 deaths recorded as due to membranous croup during those thirteen years previous to 1859 were all caused by diphtheria, while not a single fatality from that malady was reported in the city during that time 2 Had the croup of these days been diphtheritic, surely the other forms of diphtheria must also have existed. The history of the advent of diphtheria into the city of New York is likewise interesting. Previous to 1858 only three deaths were recorded as being due to diph- theria during the present century. While the deaths from croup ranged from 338 to 378, those from diphtheria varied from 5 to 2,329. Dr. Smith thus remarks: In the first years after the introduction of diphtheria, the deaths assigned to croup so greatly outnumbered those of diphtheria, as in 744 NEW YORK STATE MEDICAL ASSOCIATION. 1858 when 5 died of diphtheria and 478 of croup, that it is evident that most of the cases of croup in those years were attributable to other causes than diphtheria. It is strange that for three-quarters of a century an affection so grave and characteristic in its manifestations as is diphtheria should have repeatedly occurred in the practice of thousands of intelligent physicians solely as a local lesion of the larynx without presenting one of its most prominent features, namely, septicaemia. After making due allowance for the unavoidable errors of statistics, the above data would seem to furnish pretty strong evidence in the support of the correctness of my vision—namely: that pseudo-membranous laryngitis may not always be due to the diphtheritic poison. The words of Dr. Gay, referred to earlier, would express my idea pretty well. Unless primary (membranous) and secondary (diphtheritic) croup are separate and distinct affections as regards their aetiology—or in other words, unless pseudo-membranous laryngitis under certain circumstances arises from other causes than the contagion of diphtheria—it must be admitted that either the character of the disease has changed very greatly during the past thirty years, of which there is little or no evidence, or the observations of the older practitioners were imperfect and untrustworthy. But the one great distinction which is pathological and which is ques- tioned, though it would seem of great importance, is the difference in the exudation, that of membranous croup lying upon the surface of the mucous membrane, while the other is imbedded in it. In diphtheria we recognise a disease epidemic and eminently contagious, of an asthenic type from its very commencement. An exudation forms upon the tonsils, spreading upward and downward, with a tendency to form upon distant surfaces, e.g., blisters; the throat emitting an intensely disagreeable odor; it occurs at all ages, and paralysis is a prominent sequel. On the other hand, croup is found to be a sporadic disease, doubt- fully if at all contagious, and of rather asthenic character at first. In it the larynx and trachea are the parts first attacked, the tendency to spreading is far less marked, there is no accompanying odor, it is exclusively a disease of childhood, and paralysis is not a sequel. In diphtheria, albuminuria is almost always present ; it is not present in membranous croup. In diph- theria the glands of the neck are swollen and tender ; in croup they are not. The argument against this is that the mucous membrane of the larynx has no communication with the superficial cervical glands, and as an example, attention is called to the fact that in cancer of the pharynx the cervical glands are always enlarged, while in cancer of the larynx they are seldom, if at all, affected. In answer to the statement that paralysis follows in diphtheria, we are met with the argument that it is rare in croup because nearly all of the cases terminate fatally, and that paralysis is occasionally met with. Membranous croup generally begins as an ordinary cold, more or less cough, hoarseness and fever. The throat is usually sore, and the cough is rather harsh and metallic and attended with very little expectoration. In diphtheria, we have a prodromal stage of a day or two, during which the PROCEEDIWGS THIRD DISTRIOT BRANCH, 745 patient feels somewhat indisposed, has slight fever, and may complain of somewhat painful deglutition—more marked when swallowing fluids than solids—some headache and occasional vomiting. This would pretty fairly represent the early stages of the two affections, and to a casual observer they would appear identical. An inspection of the fauces in the early stages of membranous croup is likely to reveal little Save congestion and perhaps a thin exudation, confined for the most part to the tonsils. In the diphtheritic variety, the exudation is seen early, and is more abundant, Spreading over more surface, frequently being upon the uvula, soft palate, cheeks and nares. At this time the fever is usually marked, the glands of the neck Swollen and tender, and the membrane, instead of appearing as a Whitish gray, is of an ashy-gray color. In membranous croup there is an entire absence of these symptoms, and instead, a persistent hoarseness, increase of the metallic breathing, and at about the time Septic symptoms are well developed in diphtheria, dyspnoea occurs in membranous croup. With the ashy-gray exudation we do not get the same train of prodomal symptoms that we find with the whitish-gray exudate, nor do we find the same tendency to implicate or extend to the larynx. In the author's experience, the whiter the deposit, the greater the tendency to extend to the larynx. Thus it would seem plausible that there is a wide distinction between membranous croup and diphtheria, both in the early and latent stages, as well as in the character of the membranes; that a disease of the follicles of the tonsils is not necessarily diphtheria is shown by the fact that the deposit in the former is pulpy and can be wiped from the surface of the mucous membrane, and does not come off in strips, with the usual result to the underlying membrane, as in diphtheria; the patches are never prominent, are usually more circumscribed, and dip down into the lacunae, or rather project from the crypts upon the surface of the tonsils. This paper was discussed by Drs. Ross, Seymour, Lester, Greene and Dudley. The drift of opinion was that diphtheria and croup were identical dis- 63SeS. At this time the President arrived, took the chair, and read his address. A recess was now taken for dinner, which was furnished at the Ahwaga House, by the members of the Association. The afternoon session was opened by the presentation of the Orton Prize Essay. Dr. J. G. Orton introduced the reader of the paper as fol- lows: MR. PRESIDENT : It is my pleasure to report to this Association that the Essay entitled “The Control of Scarlet Fever,” has been awarded the prize I had the honor to offer at our last meeting. I am also pleased to announce that the author of this Essay is Dr. F. H. Higgins, of Cortland, and that the Committe of Examination considered it as not only entitled to the prize, but as worthy of special commendation as a paper in the line of popular sanitation. 746 NEW YORK STATE MEDICAL ASSOCIATION. ORTON PRIZE ESSAY. 1 THE CONTROL OF SCARLET FEVER. By F. H. Higgins, M. D., Cortland, N. Y. WHEN an ambush is unmasked the fear of it is gone. Diseases were mysteries; they were dispensations of Providence ; they were punishments to be submitted to. So long as the cause was unknown, and no method of prevention recommended itself, it was the part of philosophy to endure Stoically what could not be cured. By the revolution in our knowledge of the contagious diseases brought about by the germ theory, this position is radically changed. It is within the last decade that a sure basis for our belief in the bacterial origin of disease has been reached. But already so much has been made clear that tame submission to epidemic is criminal. The first struggle against such diseases as scarlet fever, diphtheria and measles, was a defensive one. Long ago it was found that after such a malady had gained an entrance into the system, almost nothing could be done to arrest its course until its force was spent. In spite of a vast amount of experimentation, this fact still remains true. After one of these contagious diseases has once developed, good nursing may help the stricken One, but we are entirely unable to reach the fons et origo in his case. There is something, however, that we can do. One of these attacks is as much an accident as to be struck by a rifle ball. It is the result of an extraneous cause acting upon the system. The feeble and the strong are equally liable. The earliest efforts of physicians and friends were confined to serving as an ambulance corps to care for the wounded. Then, as some idea of the direction of the invisible arrows was obtained, defenses began to be erected. By isolation, diseases were not allowed to spread so rapidly from one to another until whole families and communities were laid low. Common observation had taught us this before the microscope had clearly revealed Our enemies to us. Now, by the great increase in the exactness of our knowledge, we may begin an aggressive warfare. We are just beginning to reach that import- ant principle that the best defense is an attack. We are just finding out that there is a possibility of annihilating such diseases as scarlet fever SO that we need fear its ravages no more. If such an end shall be reached, it is essential that not only physicians, but every member of the community, shall know the plan of attack and assist in carrying it out. * In the first place, it needs to be thoroughly, radically, and once for all understood that scarlet fever is a contagious disease, and that when any case occurs, it has been contracted from some other case, either directly or indirectly. 1 This essay was awarded the prize (a complete set of the Medical and Surgical His- tory of the War), offered by Dr. J. G. Orton, of Binghamton, in aid of popular Sanitary Science. PROCEEDINGS THIRD DISTRICT BRA. WOBI. 747 Generally by careful investigation this can be shown. Cases do occur, however, in which the connection cannot be discovered. When we re- member that the contagium is something unappreciable to the ordinary senses; that momentary contact with a garment that has been worn by a person who has had the disease is sufficient to cause it ; that the disease does not manifest itself until some days after it has been received into the system ; that it can be carried by the milk we drink, caught in a street car from one just recovering, or brought by a well person from the sick room, it is little Wonder that in some cases an exact statement of the cause cannot be given. There was a time when farmers explained the appearance of thistles on a piece of new ground by spontaneous generation, and when frogs were thought to come from clouds. After all the world had con- ceded that animals and plants such as these came from an ancestor like themselves, there still remained scientific men, who believed that the micro- scopic life which always appears in standing water or organic infusions, was of spontaneous origin. The careful experiments of Pasteur, repeated many times by scientific men everywhere, have shown that in every case the development of living organisms, even of the minutest and simplest kinds, is owing to the presence of germs carried thither by the air or some other medium. The ordinary kitchen operation of canning is an every day ex- periment proving the same thing. If mould appear in the fruit, no woman explains it by chance or by development inside the can, but knows that the cover has become loose, and outside air, germ laden as it is, has gained entrance there. Precisely the same is it with the germ of scarlet fever. We may be sure if we find it present that it came from somewhere. How did the first case originate 7 We know as little about this as about the origin of life anywhere else ; but this we know : snakes, tigers and Eng- lish sparrows will not develop spontaneously if we can get rid of those now On hand. We need have no fears, then, that our labors of extermination may be frustrated by the disease all at once appearing de novo. Although there is still some dispute as to the exact appearance and Scientific name of the disease germ of scarlet fever, something may be stated. It is probably a bacillus. These bacilli are long, narrow, rod-like germs, often in chains by attachment end to end. It has been called provisionally bacillus Scarlatinae. It has been cultivated and grown outside the body on the serum of ox blood. We know some of the conditions most favorable to its growth, and what substances are prejudicial to it. This part of our knowledge is still fragmentary, but owing to the zealous work of micro- Scopists, is rapidly increasing. By comparing what has been learned by direct observation of this germ with what we positively know of its con- geners, a very clear idea of its behavior may be obtained. After the entrance of the germs into the system, about three days are devoted to their multiplication before they have reached a sufficient num- ber to produce any visible effect. This time may vary according to the number and activity of those introduced ; then languor and vomiting are followed by red throat and strawberry tongue; this soon by a bright red 748 NEW YORK STATE MEDICAL ASSOCIATION. rash. At the first stage of the disease every part of the system is reached by the germ and may give it off to someone else. The germs floating in the breath and in the exhalations from the body may carry the disease, but not a long distance. It has been discovered that one must come as near as three feet to receive the disease at this time. This is contagion by personal contact. It rarely occurs. Fortunately it does not occur at all until after the fever is plainly manifest. It is like a rattle-snake, and gives fair warn- ing before it strikes. It is very different from measles in this respect, for this is most dangerous to others when the child is first coughing and no rash has yet appeared. During the height of the disease it is said that the bacill: Scarlatinae cannot be found. It would not be safe to say that the disease was not then, to any degree, contagious, but with careful isolation it certainly can be kept from spreading. It is after the height of the fever has passed, and the little one in a fair way to being well again, that the danger is greatest. Now the skin is flaking off in shreds and scales all loaded with the germs, seeking new fields to conquer. The skin is the peculiar location of the dis- aase, and from it the contagion spreads. It is not now by exhalations in- nocuous at arm’s length, but by floating scales bearing the bacilli upon them like warriors in their chariots. These lodge in clothing, propagate themselves in milk, and are even transported by the mails for hundreds of miles. It indeed appears like one of the labors of Hercules to follow and destroy these myriads; and so it is. But to prevent their escape is not so desperate an undertaking. When the lid to Pandora's box was raised, by no possibility could all the evils there contained be recaptured or sub- dued. In the past we have been as foolish as she. By simply keeping the skin greased, the far and wide dissemination of the disease during convalescence may be stopped. By adding to the un- guent some substance detrimental to the germ, and not harmful to the patient, such as thymol, or eucalyptolor carbolic acid, the safety is rendered nearly absolute. A small amount of oil of eucalyptus in lard or sweet oil makes almost an ideal preventative of danger at this period, and is rather beneficial than otherwise to the sufferer. So confident are some practitioners in the efficacy of systematic unctions to prevent contagion that they do not hesitate to allow intercourse with other members of the family, even while the desquamation is going On. But it is not wise to trust to this alone. Before the patient is restored to society he should be given a final, thorough bath ; especial attention should be paid to the hair and any place that might afford lodgment to the bacteria. With a final greasing and clean clothing throughout, he may return to the family or to School. It would be a grave oversight, however, to carefully disinfect the patient and neglect to destroy all the contagium in the bedding and room which he occupied. It is to simplify this part of the work that it is so much bet- ter at the commencement of the disease to put the bed into a bare room. In such a room, with no lurking places under carpets and behind curtains, our enemy stands but poor chance in a hand to hand conflict with such PROCEEDIWGS THIRD DISTRIOT BRANCH, 749 modern weapons as carbolic acid, corrosive sublimate and boiling water. These germs are weak individually ; they are strong only in numbers. Let one case in an ordinary family illustrate just how we may get rid of Scarlet fever there. The oldest boy in a family of four had just begun to attend the public school. Some of the Scholars had scarlet fever about their clothes and gave it to our little friend, for which, in my opinion, an action for damages would be perfectly justifiable. As soon as the rash began to appear, a bed- room upstairs was emptied completely. A bed, stand, and two wooden chairs were allowed in the room, with a small stove. A sheet dampened with carbolic acid water was hung over the door. The mother or nurse attending him was directed to go to the other parts of the house as little as possible. If obliged to leave the room, she was to wash and change her gown. After the fever subsided and peeling commenced, the child was well greased all over twice a day. At the end of about three weeks, although four weeks is the rule, he was well washed, especially the hair, greased, dressed in clean clothes, and allowed to go down stairs. The bedding was thrown out the window on a low roof, and allowed to air all day. It was then boiled in chlorine water made by adding two ounces of white vitriol and four ounces of salt to the gallon of water. The room was washed and mopped with corrosive sublimate in the proportion of one dram to the gallon of soft water. If there should be any nooks or corners, or any material in the room that could not be reached with the scrubbing brush, then sulphur should be burned. It must always be accompanied by steam, and used in large amounts. The proportion recommended by Dr. Edson, health officer for New York City, is three pounds for each one thousand cubic feet, used for two hours. An ordinary ten by twelve bedroom contains about one thousand cubic feet. The dish containing it should be set in a pan of boiling water in the middle of the room, a little alcohol poured over it and lighted ; then the room closed tightly and left for two hours. There is no danger, but some kinds of goods will be bleached by it. It must not be forgotten that fresh air and sunlight are death to these germs, and are two of our best weapons. In this case that has just been detailed, not one of the little brothers or sisters took the scarlet fever, nor did any case arise from it. At that par- ticular point scarlet fever was annihilated. That the fortunate result was due to care, not luck, was illustrated in less than a month, when this little one broke out with chicken-pox. While Scarlet fever is the most terrible scourge of childhood, chicken-pox is the mildest. So the children were allowed to play together, and as a result, as might have been expected, it affected them all. The means taken to limit the spread of scarlet fever in this case are no more than can be easily car- Tied out by any ordinary family. It is certainly less trouble than to nurse another child through the sickness. The happy results when the plan, simple as it is, is well carried out, certainly justify the effort. The details in each house may be varied intelligently, provided we are acquainted with 750 NEW YORK STATE MEDICAL ASSOCIATION. the object to be attained, and the means adequate. For we fight not as one that beateth the air now that we know as much of the habits and nature of the germ as if it were a visible enemy. Diseases of foreign importation, as the plague, cholera and yellow fever have been held at bay by such means as these. Is it not time to plan a campaign against some of our intestine foes? The inducements to such action are certainly strong enough. At least one-ninth of all the cases of deaf-mutism are owing to scarlet fever. Of the large number of cases, deaf in one ear, perhaps one-half are due to the same cause. A large contingent of cases of kidney affections date back to scarlet fever. A chronic sore throat is often the result of the disease. The number of deaths directly due to it is excelled by none of the child- ren’s diseases. The excuse given for allowing children to catch the measles—that they had better have it and done with it—cannot apply here. Scarlet fever is most severe and dangerous in younger children; older persons escaping altogether. These is no other contagious disease whose habits are better understood or that can be more easily arrested in the present state of our knowledge. Whatever excuse there may be in allowing all other fevers to spread a their own sweet will, there is none for scarlet fever. When we shall be successful in subjugating this, the armament and ex- perience obtained may be hopefully turned to such lurking enemies as diphtheria. That so general and horrible a disease as small-pox has been thoroughly controlled by vaccination, has ever since been an inspiration in the efforts to obtain similar results in others. But although thousands of experiments have been made, no vaccine has yet been discovered for the disease under consideration. Pasteur's inoculation for hydrophobia is promising, a yellow fever inoculation is being investigated, and there is still a ray of hope in Koch’s consumption cure. But none of them is yet beyond the experimental stage. Enough has been found out to warrant the hope that some virus may be discovered which, introduced into the system, shall for- tify it against these diseases. Possibly some phagocyte may be found which shall defend the system of a child from the scarlet fever germ. But these studies are after all working at the wrong end of the prob- lem. An attack is the best defense. We do not in this age erect high walls around our cities, but place cannon there. Soldiers do not encase themselves in steel armor, but depend on their guns and the generalship of their leaders to defend them. We may better strike the enemy than to spend all our time manufacturing improved breast plates. Can such a campaign be practically carried out 7 There are doubtless difficulties. If there were not, it would not have now been left unaccom- plished. Nor is there any other way to surmount them than by steady persistence in some well directed plan. It must be as Grant captured Petersburg. Convinced that our forces are superior to those that are against us, we must move on the enemy and fight it out on this line if it takes all summer. PROCEEDIWGS THIRD DISTRIOT BRAWOH. 751 Paradoxical as it seems, one of the most perplexing difficulties is the occurrence of mild cases of the disease. Although the disease is one of the most malignant known, a large proportion of the cases are of a very mild type. The child does not complain, the rash is very slight, and the whole case is managed by the mother as “Scarlet rash ;” or perhaps a doctor is called in and does not like to frighten the family, and so calls it scarlatina. Scarlatina means nothing less than scarlet fever, and “Scarlet rash ’’ given to a neighbor’s child, may be fatal scarlet fever as well as if caught from the most Severe Case. Isolation, cleanliness, inunctions and antiseptics are just as important in these light cases as in any, if the disease is to be stamped out from among us. Fortunately, at least for general interests, selfishness alone will lead to a proper care of these cases if the whole matter is properly understood. No physician who has seen the dropsies, rheumatisms and running ears resulting from the neglect of these mild or unrecognised cases of scarlet fever, can conscientiously fail to warn his families of the results of such laxness. As the public generally come to understand medical matters better, as they are doing, these light cases will be better cared for. It should be thoroughly and generally understood that a “scarlet rash” is a snake in the grass, both to the patient and to the community. Certain epidemics of scarlet fever, especially in England, have been thought to originate from cows afflicted with a disease of similar nature. If this be so, it would seem to complicate the situation very materially. If new centres of infection may appear at any time from contact with the lower animals, then there is some excuse for despairing of ever ridding ourselves of this scourge. The result of all the investigations on the Hen- don outbreak, however, seems to be that the disease among the cows was not scarlet fever. It is more likely that in such cases the milk becomes in- fected from some cause after it is drawn, and that is a matter which we may and should control. Criminal proceedings are none too severe for a milkman who will allow a case of scarlet fever in his family to communicate the disease to all the children on his route through the medium of the milk. Another practical difficulty in securing general co-operation is the cases which occur in indigent families. With only one room in the house, with Only one fire and no possibility of getting another, with no conveniences and no help, the task of carrying out the prophylaxis described, simple as it is, looks impossible. Many times with such conditions the physician abandons all attempt to separate the sick from the well, with the inevitable result that all the children in the family are affected, with more or less fatal result. The neighbors' children follow, and from them a local epidemic. Pessimists among physicians and health officers point to such occurrences and Say all efforts are hopeless. To them the idea of overcoming the disease looks as Utopian as the decree of a king to abolish death in his domains. But would it not be policy for the government to take charge of such Cases, and do for them what the families themselves cannot do 2 Does not the loss to the State now resulting from the devastation of the disease 752 NEW YORK STATE MEDICAL ASSOCIATION. more than counterbalance, on a money basis alone, all the expenditure which would be involved in combating it 2 It is true that in poverty stricken homes no adequate measures for pre- venting the spread of disease to the families about, or to the children of the same public school, can be depended on. But if an officer were ap- pointed in each town or ward, with sufficient authority and compensation, the thing could be done. Either by supplying proper nurses, or taking the case to a hospital, such care could be given that the rest of the family could be spared and the community at large not imperilled. In all this work, too, the object would not be simply to protect certain individuals at certain localities, but to know that the spread of the disease itself was checked. It will add much to the enthusiasm with which conscientious physi- cians and families now endeavor to meet the disease, to know that the same work is being done all along the line. By a general oversight it should be possible to trace a steady and rapid decrease in the amount of scarlet fever in the land. What louder call on the knight-errantry of the nineteenth century than to endeavor to destroy this hydra-headed monster that has been devouring our children ? SUMMARY. The cause and transmission of scarlet fever is now sufficiently under- stood to enable its spread to be controlled. By concerted action and State supervision, it is possible to rid our country of this one disease. The factors favorable to such a result are: 1. The disease is seldom given during the first stages or when it cannot be recognised. 2. Immunity extends to within three feet of the patient, in the first stages. 3. The spread of the disease is due almost entirely to the epithelial scales exfoliated from the skin. 4. The danger from this exfoliation can be controlled. 5. Simple rules carried out render safe the room in which the patient has been confined. 6. A general destruction of the disease germs wherever they manifest themselves, will soon greatly diminish its prevalence and the difficulty of its control. The difficulties which beset the practical carrying out of such a general campaign are : 1. The neglecting of mild cases, which must be met by more general education and stricter reports to health officers. 2. The possibility of new centres of infection from lower animals, although this is rare and doubtful. 3. The lack of definite information on the subject, which must be met through the public press. 4. The occurrence of the disease in homes of poverty, where means for its suppression will not be carried out by the family. These cases must be cared for by the State, which can well afford to do it. PROCEEDINGS THIRD DISTRIOT BRANCH, 753 The last paper was by Dr. J. G. Orton, and was entitled “An Inter- cranial Lesion; Ante-Mortem Localisation; Autopsy.” A lady about fifty years of age, while at the seashore near New York City in June, 1890, was suddenly seized, without former cerebral symptoms except headache, with left hemiplegia (face, arm and leg) but without complete loss of consciousness, and without marked sensory disturbances of previous clonic spasms, and without other speech derangement than the usual dysarthria of hemiplegia; but after being removed to her boarding place in New York, she exhibited mental confusion, and at times, con- siderable delirium. She was placed under treatment by competent physi- cians, who diagnosed at One time cerebral haemorrhage, at another, a tumor, and at still another, a possible abscess. Improvement of the paresis fol- lowed in a few weeks, but the mental symptoms did not disappear. She had a good appetite, and was able to go out of doors for a walk, and at times seemed quite herself; but there soon supervened a second attack in which paresis became worse in the same parts as before. I learned this history of the case from her attendants. In the early part of August she was removed to Binghamton, and came under my care. On the day of her arrival she readily knew me, and could talk quite well. She was, however, easily confused as to her surround- ings; tongue clean, bowels regular, appetite good, pulse 80, temperature 100°, pupils normal, body well nourished. She had so far recovered from the paralysis of the left side as to use her limbs fairly well, and sensation was nearly normal. On my visit to her the next day, she was unable to help herself and could only utter a few inarticulate sounds, but evidently understood what was said to her, as was indicated by squeezing with her right hand when requested. The left side was completely paralysed ; the tongue could be protruded, but the eye-lids could not be opened wide. Coma gradually increased until these movements were also abolished, and paraplegia was fully established. A third nerve paresis of the right side was evinced by the ptosis, position of the eye-ball and dilatation of the pupil. The stupor was quite Continuous, although she could be partially aroused long enough to take liquid food if carefully given. She made no effort to move the extremities or tongue on request ; possibly there was a slight effort to squeeze with the right hand on being thoroughly aroused. Sensibility seemed normal to painful impressions, such as pricking ; but tactile sensibility could not be determined. The superficial (skin) reflexes were preserved in the lower extremities. The knee-jerks were present, but were more active on the left side. There was some contraction of both the left arm and leg; no quick clonic movements, but slowly increasing and relaxing tonic spasms, when She would also frequently moan and cry out. The facial movements ex- hibited slight facial paresis (cerebral type); deglutition was as in states of partial coma. The pupils responded to light sluggishly, the left more than the right, but would suddenly dilate when she was moved or aroused. There was no persistent conjugate deviation, but the eyes would move about, sometimes resting to one side, sometimes to the other. The fundus 754. JNE W YORK STATE MEDICAL ASSOCIATION. appeared under the ophthalmoscope normal; there were no signs of optic neuritis or atrophy. About the first of October, there appeared a discharge of pus from the right ear, and also from the mouth. This continued for three weeks, and then gradually ceased. This circumstance naturally led to the suppo- sition of a possible abscess either in the mastoid cells, or even intercranial, and the subject of surgical interference was discussed. As this case had continued so long, and its true nature unrecognised, or rather the intercranial lesion unlocalised to my satisfaction, I had taken pleasure in inviting several of our local physicians to examine the case ; but our consultations did not result in any very positive views as to the exact location of the intercranial lesion. In order to settle, if possible, the advisability of resorting to surgical measures, I asked that a neurologist be called in consultation, and accordingly, at my suggestion, the late Dr. W. R. Birdsall, of New York City, visited the patient on the 24th of December, 1890. He made an exhaustive examination, and after his return home wrote me a letter from which, with your permission, I will quote freely, and I am sure you will be pleased with the light which he throws upon the case, and his positive opinion in regard to the impossibilities of relief from surgical interference. It will also be interesting to see how his diagnosis has been remarkably corroborated by the autopsy. In this connection it is indeed sad for me to record the sudden death during the past week of this comparatively young but already dis- tinguished physician, justly eminent as a neurologist. Dr. Birdsall said in his letter: “The sudden onset of the first attack without former local, sensory or motor disturbances, and the complete hemiplegic character of the attack (face, arm, leg and dysarthria) without occular symptoms, pointed to a lesion of the right internal capsule—being too extensive for a cortical lesion—probably an arterial lesion concerning whose nature, whether from haemorrhage, embolism, thrombosis or occlu- sion, could only be inferred from the probabilities in favor of the different causes of these states. The second attack would have to be considered as of a similar nature to the first, but its location not easily determined ; the prolonged coma was the most difficult thing to account for, the probable view being a large area of softening from extension into some area not giving rise to sensory or motor phenomena, though the rapid accession of the coma may have masked many symptoms. “The third nerve (right, crossed paresis) pointed to an intercranial peduncular lesion ; such lesions, however, are more frequently due to neoplasms than to disruption from haemorrhage or the products of soften- ing. The prolonged coma is also more consistent with tumor or abscess than with arterial disease, but the character of the first attack and the ab- sence of optic neutritis are opposed to either tumor or abscess, nor Was there any history of deafness or former ear disease. The subsequent dis- charge of pus fom the ear opposite the paralysed side again raises the question of abscess, but the nature of the attack is strongly opposed to ab- scess. The examination of the ear shows a large perforation which has PROCEEDINGS THIRD DISTRIOT BRANCH, 755 destroyed more than one-half of the tympanum. There were no signs of active suppuration, and no thickening of the walls of the canal indicating bone disease. The patient has doubtless had an abscess of the middle ear as an intercurrent affair not connected with the intercranial trouble. Ten- derness over the mastoid could not be elicited ; which test, however, is of little value when so much stupor is present. “I can see no warrant for surgical interference concerning the ear trouble The cessation of the discharge of pushad no effect on the cerebral symptoms. “From the history of the patient since the second attack, and the examination recently made, I should say there is but little change as regards the motor, Sensory and reflex phenomena. There is an increase in the tonic spasms or attacks of general rigidity which supervene when she is not in a proper position, and which are bilateral. There is no rigidity of the neck, and no vomiting. The third nerve paresis is not as marked as earlier in the course of the disease, but is still present. There are still traces of facial paresis. The knee-jerks are more active, the left preponderating. Elbow jerks are present, right and left. The fundus occuli does not show any signs of choked disks or optic neuritis, but the disks are decidedly changed in color. They present a degree of whiteness which must be considered atrophic, but without signs of former optic neuritis. To a feeble light the pupils do not react, but to a strong electric light they react sluggishly. “From the history of this interesting case and the examinations which have been made of the patient, I am of the Opinion that there has been an arterial occlusion followed by softening, involving the right internal capsule and afterward other deep seated and central portions of the brain. There can, therefore, be no warrant in my opinion for intercranial surgery, and no justification for attempting to remove the products of cerebral softening. The indications of a localised cortical lesion are not evident.” The prognosis of this case was of course unfavorable, and treatment could afford nothing in the way of repair of damage done to completely occluded arteries, or restore function to softened areas of cerebral tissue. The patient died on the 9th of March, 1892, nearly two years from the date of her first attack, apparently from congestion of the lungs. At the autopsy, sixty hours after death, kindly performed by Doctors Moore and Rodgers, of Binghamton, we found the inner surface of the skull smooth and free from any signs of disease. The dura mater and pia mater were normal in character. The convolutions and superficial vessels were also normal. There were no evidences of disease of the mastoid. We found an area of sclerosis involving nearly the entire right cuneus; an area of softening of a considerable portion of the interior of each thalamus (certainly three of the four ganglia of the right side); the greater portion of the right lenticular nucleus, and also some of the fibres of the adjacent posterior segment of the right internal capsule. All other portions of the brain seemed normal in character. After the transaction of some miscellaneous business, the Association adjourned. L. J. BROOKS, President. 48 W. L. AYER, Secretary. FOURTH DISTRIOT BRANCH. The eighth annual meeting was held at the Hotel Iroquois, Buffalo, on Tuesday, May 10, 1892. The morning session was called to order at 11 A. M. by the President, Dr. J. B. Andrews. The minutes of the previous meeting were read by the Secretary, and were approved. President Andrews read the annual address upon the subject, “Inebrie- ty—a Vice, a Crime, or a Disease ?” - The Treasurer presented his annual report, showing a balance on hand of $35.28. Upon motion of Dr. Putnam, the report of the Treasurer was adopted. The Secretary moved that the order of business be changed, and that we proceed with the scientific programme. Carried. The first paper was presented by Dr. James W. Putnam, and was entitled, “Brain Tumor, With Report of Cases.” Dr. Wm. H. Bergtold, who had made the autopsy in one of the cases referred to, presented the specimen to the Association. Dr. C. C. Frederick then read a paper upon the subject, “Why is Intra-Uterine Irrigation so Often Ineffectual in Puerperal Septicaemia 7” The paper was discussed by Drs. Stockton, Parmenter and Hayd. Dr. John C. Parmenter next read a paper on “A Case of Gun-Shot Wound of the Brain.” The paper was discussed by Drs. Putnam, Phelps and O’Brien. The President requested the members present from each county to select a member of the Nominating Committee. AFTERNOON SESSION. The meeting was called to order by the President. The Nominating Committee presented their report, and the following named Executive Committee was duly elected for the ensuing year: J. A. Stephenson, M. D., Scio, Alleghany County. S. J. Mudge, M. D., Olean, Cattaraugus County. Nelson G. Richmond, M. D., Fredonia, Chautauqua County. C. C. Frederick, M. D., Buffalo, Erie County. M. W. Townsend, M. D., Bergen, Genesee County. F. H. Moyer, M. D., Moscow, Livingston County. R. M. Moore, M. D., Rochester, Monroe County. W. Q. Huggins, M. D., Sanborn, Niagara County. F. D. Wanderhoof, M. D., Phelps, Ontario County. PROCEEDIWGS FOURTET DISTRIOT BRAWOH. 757 John H. Taylor, M. D., Holley, Orleans County. Jeremiah Dunn, M. D., Bath, Steuben County. Darwin Colvin, M. D., Clyde, Wayne County. A. G. Ellinwood, M. D., Attica, Wyoming County. William Oliver, M. D., Penn Yan, Yates County. Dr. G. W. Goler, of Rochester, presented the ovaries and tubes from a prostitute, thirty-one years of age, showing interstitial changes in the tubes due to gonorrhoea, the invasion of which occurred sixteen years before death. The tubes were atrophied and presented nodules of cicatricial tissue, occluding their calibre at various points. The fimbriae were not invaginated, but their stunted remains formed a canal covered in by peri- metritic adhesions directly continuous with the ovary. The ovaries were small and markedly cystic. Dr. F. W. Bartlett reported the successful treatment of a large number of cases of acute dysentery by flushing out the lower bowel with a stºry solution of bichloride of mercury, using about two quarts at blood tem- perature. He had also used similar treatment in eighteen cases of typhoid fever, and had had no fatalities in this disease since beginning this treatment. Dr. C. C. Frederick spoke in favor of flushing the colon in dysentery and all forms of entero-colitis, and in cholera infantum. In all cases he had met with favorable results, Upon motion, the meeting adjourned. J. B. ANDREWS, President. WM. H. THORNTON, Secretary. FIFTH DISTRICT BRANCH, The eighth annual meeting of the Branch was held at 315 Washington street, Brooklyn, on Tuesday, May 24, 1892. In the absence of the President, the morning session was called to order by the Secretary at 11.30 A. M. On motion, Dr. W. T. White was called to the Chair. The Secretary read the minutes of the last meeting, which were approved. The report of the Committee of Arrangements was read and ordered On file. - - The Chairman appointed Drs. W. G. Russell and J. R. Wanderveer to act with the Secretary as Registration Committee. The next order of business was the President's Address, but as Dr. Van Hoevenberg had not yet appeared, the meeting proceeded with the order. There were no reports of delegates. There was no formal report from the Executive Committee, but the Secretary read the minutes of the committee for the past year. These were approved as read. The Treasurer's annual statement was then read and approved. Under the head of Report of Special Committees, the Committee on Necrology reported that there had been five deaths among the Fellows of Our District since the last annual meeting—two of whom were founders : Dr. David Matthews, Dr. Abram DuBois, Dr. N. C. Husted, Dr. Lucien Damainville, Dr. Rutson Maury. There was no unfinished business. Under new business, the Secretary announced that he had received programmes of the Seventh Annual Meetings of the Second District Branch, to be held in Troy on June 25, 1891, and of the Third District Branch, to be held in Binghamton on June 18, 1891, also for the Eighth Annual Meeting of the Fourth District Branch, to be held in Buffalo On May 10, 1892. - The biographical sketches were then called for. In the absence of Dr. Flint, the Secretary read Dr. Flint's memoir of the late Dr. Lucien Damainville. As Drs. Purple and Coutant were not present with their sketches, Dr. McLeod was called upon to read his re- marks on the late Dr. David Matthews. As some very recent data had been obtained in regard to the life of Dr. Matthews, Dr. McLeod asked PROCEEDINGS FIFTH DISTRIOT BRANCH, 7.59 permission to retain his sketch until he had perfected it. The Secretary announced that, according to the custom, these sketches would be referred to the Committee on Necrology of the State Association for publication. As Dr. Rutson Maury had died so recently, there had not been sufficient available time to secure any extended remarks, but the Secretary read the following newspaper clipping, which might suffice for the present : “Dr. Rutson Maury died at 9.30 A. M., Thursday, May 5, 1892, at St. Luke's Hospital, from pneumonia. He was taken sick from overwork on the Fri- day before, and removed to the Hospital. “He was born on August 15, 1865, at Milton, N. C. Son of the late William Lewis Maury of the United States and Confederate States navies, he attended Grammar School No. 40 in New York City, and was gradua- ted from the College of the City of New York in 1884. The same year he entered Bellevue Medical College, and was finally graduated at the head of his class. He was the first student in the college who ever received a per- fect mark in everything in his final examinations. After going through the Bellevue Hospital course, he became associated with Dr. Lusk, and was his assistant up to his death.” The scientific papers were then taken up. Dr. John Blake White's paper was called for, but as he was not present it was announced to be called up during the afternoon session. Dr. T. H. Burchard next read his exhaustive paper on “The Therapeu- tic Efficacy of the Saratoga Mineral Waters.” Discussed by Drs. Newman, McCollom, McLeod, Paine, and the following invited guests : Drs. E. H. Bartley, M. C. O’Brien, J. R. Goffe and E. Reynolds, and closed by the author. The Secretary here stated that all the papers read would be published. Choosing a Nominating Committee to nominate members for an Execu- tive Committee for the ensuing year was then in order. The Secretary called off each county in the District in alphabetical order, and the Fellows present from each county named the Fellow to represent that county on the following Momčnating Committee : Dutchess County, I. D. Le Roy. Kings County, J. D. Sullivan. New York County, J. G. Truax. Orange County, M. C. Conner. Putnam County, G. W. Murdock, Queens County, None present. Richmond County, F. U. Johnston. Rockland County, None present. Suffolk County, Walter Lindsay. Sullivan County, None present. Ulster County, None present. Westchester County, Nome present. The committee was then requested to meet during the coming inter- mission. Adjourned for lunch at 1.40 P. M. 760 NEW YORK STATE MEDIOAL ASSOCIATION. The afternoon session was called to order at 2.45 P. M., Dr. W. T. White still in the chair. The Scientific work was immediately resumed by Dr. J. E. Janvrin reading his paper on “The Limitations for Waginal Hysterectomy in Ma- lignant Disease of the Uterus.” Dr. George Tucker Harrison opened the discussion by reading from notes. Dr. Alex. J. C. Skene, as an invited guest, was called upon, but as he could not be present he sent his apolo- gies and his remarks written out, which the Secretary read in full. The paper was further discussed by Drs. A. F. Currier and J. R. Goffe, both invited guests, and finally closed by the author. Dr. J. R. Wanderveer next read his note on “Retention of Menstrual Blood from Imperforate Hymen.” Discussed by Drs. Janvrin, Harrison, Minard and Burchard, and closed by the author. By special request, Dr. S. E. Milliken was permitted at this time to demonstrate Bassini's Operation for the radical cure of Hernia. Colored plates were used, so arranged as to make the demonstration clear. Dis- Cussed by Drs. Armstrong, Harrison, Burchard and A. F. Currier (guest), and then closed by Dr. Milliken. Dr. W. D. Granger's paper was then called for, but as he had to leave before it was called, he desired to have his paper read by title—“Voluntary Patients in Asylums for the Insane.” Dr. S. W. Smith was next called upon for his paper, but he had pre- viously begged to be excused, as he was called away. Dr. S. T. Armstrong then read his paper on “Brown-Sequard’s Par- alysis Resulting from Syphilis.” No discussion. Dr. J. B. White was now called upon to read his paper, which had been postponed from the morning session on account of his absence. Owing to the lateness of the hour he begged to be excused. The scientific business having been completed, the Nominating Com- mittee made its report as follows : For Member of Faecutive Committee to represemi– Dutchess County, I. D. LeRoy. Rings County, J. D. Rushmore. New York County, T. H. Manley. Orange County, M. C. Conner. Putnam County, G. W. Murdock. Queens County, E. G. Rave. Richmond County, F. U. Johnston. Rockland County, Wm. Gowan. Suffolk County, W. D. Woodend. Sullivan County, W. H. DeKay. Ulster County, H. Wan Hoevenberg. Westchester County, H. E. Schmid. On motion, the report was accepted and approved, and the committºº discharged. PROCEEDIWGS FIFTH DISTRICT BRA. WCH. 761 The chairman then called for a meeting of this new committee immedi- ately after adjournment, but it was seen that there were only two of the committee present, therefore a meeting could not be held. Adjournment was then declared at 5 P. M., to meet next one year from this date. The register showed 42 Fellows, 3 delegates from the Kings County Medical Association, and 9 invited guests present. H. WAN HOEVENBERG, President. E. H. SQUIBB, Secretary. *º-mºs EXECUTIVE COMMITTEE. A called meeting of the Executive Committee was held at 315 Wash- ington street, Brooklyn, on Tuesday, May 24, 1892. In the absence of the President, Dr. Van Hoevenberg, Dr. White was asked to act as temporary chairman until the President arrived, and the meeting was called to order at 10.15 A. M. Present—Drs. W. T. White, M. C. Conner, F. U. Johnston, I. D. Le Roy, G. W. Murdoch, W. G. Russell, E. H. Squibb. Seven members present, six absent (one vacancy). The Secretary read the minutes of the last meeting, which were adopted. The Secretary reminded the members of a circular vote dated February 20, 1892, which had been taken to choose a Committee of Arrangements for this meeting, and gave the result of that vote as 12 in the affirmative, no reply from one and no reply from another on account of a vacancy. The full committee consists of 14. The report of the Committee of Arrangements was then read as fol- lows: REPORT OF THE COMMITTEE OF ARRANGEMENTS FOR THE ANNUAL MEETING, 1892. The undersigned committee have little to report in regard to their ef- forts for this meeting, as the arrangements and contracting terms through- out were so satisfactory last year, that they have presumed to simply repeat them in all particulars. The hour of 11 A. M. was decided upon for opening the morning session. Respectfully submitted : J. D. RUSHMORE, M. D., Chairman. J. C. BIERWIRTH, M. D. T. M. LLOYD, M. D. WM. McCOLLOM, M. D. R. M. WYCKOFF, M. D. H. WAN HoHVENBERG, M. D., President, e E. H. SquEEB, M. D., Secretary, } Ev-Officio. On motion, the report was accepted. The Chairman then appointed Dr. W. G. Russell to act with the Secre- tary as Registration Committee, and stated he would appoint the third member later. 762 JNETW YORK STATE MEDICAL ASSOCIATION. The Secretary announced that there had been five deaths among the Fellows of our District during the year: Dr. David Matthews, on July 9, 1891. Dr. Abram DuBois, on August 29, 1891. Dr. N. C. Husted, November 19, 1891. Dr. Lucien Damainville, December 15, 1891. Dr. Rutson Maury, May 5, 1892. The Secretary then read the note of resignation received on June 5. 1891, from Dr. James W. Guest, owing to his removal to Kentucky, and stated it had been accepted according to the By-laws. The Treasurer next read his itemized expenses and his annual state- ment as follows: . TREASURER's ANNUAL STATEMENT, MAY 26, 1891, To MAY 23, 1892. Fifth District Branch New York State Medical Association, with E. H. Squibb, Treasurer. Dr. Cr. To balance as per | By rent of meeting rooms . . $10.00 statement, May 26, 1891, $97.06 || Catering... . . . . . . . . . . . . . . . . 60.00 Assessments collected... . . . . 48.00 | Postage... . . . . . . . . . . . . . . . . . 11.00 Interest. . . . . . . . . . . . . . . . . . . . 68.95 | Printing. . . . . . . . . . . . . . . . . . 4.50 Balance, cash on hand. . . . . . 123.51 $209.01 $209.01 PERMANENT FUND ACCOUNT. - * Ch". To total amount of fund By investment in railroad as per statement, May bonds (5% interest). . . $830.00 26, 1891. . . . . . . . . . . . . $1,000.00 | Balance on hand at inter- Contributions to fund to est. . . . . . . . . . . . . . . . . . 260.00 date. . . . . . . . . . . . . . . . 90.00 $1,090.00 $1,090.00 The cash book and vouchers were presented for verification, and the Chairman appointed Dr. F. U. Johnston to audit the accounts. The time and place for the next meeting was then discussed, and it was finally decided by vote that the next meeting, the ninth annual, would be held in Brooklyn, on Tuesday, May 23, 1893, as provided for by the By-laws. The following names were read as those to be guests of our present meeting : Invited by request of Dr. Janvrin— Dr. John Byrne, of Brooklyn. Dr. Charles Jewett, of Brooklyn. Dr. A. J. C. Skene, of Brooklyn. Dr. H. C. Coe, of New York City. Dr. C. Cleveland, of New York City. Dr. A. F. Currier, of New York City. Dr. J. R. Goffe, of New York City. PROCEEDIWGS FIFTH DISTRIOT BRANCH, 763 As delegates from Kings County Medical Association : Dr. F. C. Raynor. Dr. Jonathan Wright. Dr. L. A. W. Alleman. Dr. E. Reynolds. Dr. R. H. Sullivan. Dr. W. P. Beach. On motion, a cordial welcome was extended to the gentlemen, and they were invited to full privileges of the floor. In regard to the publication of the papers to be read at this meeting, the Secretary was instructed to adopt the same plan as followed for the past two years. The Treasurer was next authorised to send out assessment bills as heretofore for $1.00 to all those Fellows who have not joined in the Per- manent Fund scheme, as dues for 1892, and to append to each bill the usual slip inviting voluntary deposit to exempt from future assessments. |Upon recommendation, the five Fellows who had very recently joined our Association were exempted from assessment for the ensuing year. The Secretary was directed to continue to act as the Committee on Necrology. Dr. Johnston here reported that he had found the Treasurer's figures correct, and the committee then passed approval on the Treasurer's Statement. The committee had no formal report to present to the General Meeting this year, and the Chairman declared the meeting adjourned at 10.45 A. M. E. H. SQUIBB, Secretary. EINGS COUNTY MEDICAL ASSOCIATION. ANNUAL REPORT. Officers of the Kings County Medical Association : President, T. M. Rochester, M. D. Vice-President, R. M. Wyckoff, M. D. Recording Secretary, F. C. Raynor, M. D. Corresponding Secretary, H. C. Riggs, M. D. Treasurer, P, H. Squibb, M. D. Elected Members of the Evecutive Committee : E. R. Squibb, M. D., Term expires January, 1894. T. M. Lloyd, M. D.. Term expires January, 1895, Jonathan Wright, M. D., Term czpires January, 1896. J. D. Rushmore, M. D., Term expires January, 1897. In furnishing this report it is the desire of the Association to present a series of abstracts from the minutes of the stated meetings for the year 1892, such as will show in concise form the quality and quantity of the scientific business transacted for that time. The one or more papers pre- sented at each meeting have been valuable and interesting, and have, in most instances, evoked free discussion and interchange of opinion and ex- perience scarcely less important in their benefits than the communications which called them forth. The attendance at the meetings has been fairly representative of the Association's membership, and denotes a constant and steadfast interest in the life and work of the Association. STATED MEETING, JANUARY 12, 1892. At this, the forty-third stated meeting of the Association, the President, Dr. J. D. Rushmore, occupied the chair. The papers of the evening were “Appendicitis,” by Dr. W. H. Big- gam, and a “Report of a Case of Laryngeal Growth,” by Dr. F. C.Raynor, STATED MEETING, FEBRUARY 9, 1892. The President, Dr. J. D. Sullivan, in the chair. The following memorial note was adopted by the Association respecting the death of their late fellow-member, Samuel Curtis Robinson, M. D. : “This Association has learned with profound regret of the loss by PROCEEDIWGS KINGS COUNTY ASSOCIATION. 765 death of one of its early and most attentive members in the person of Dr. S. C. Robinson, and has ordered that a minute expressive of their esteem and regret shall be framed for permanent record. “In the death of our late Fellow we have lost one of the earliest advo- cates of the purposes of this organisation. While not an active practitioner of medicine and not prominent in public discussion of medical questions, he was thoroughly interested in matters bearing upon life insurance, health protection, and the progress of therapeutics, and was an eminently clear and logical judge in discussions of these questions. ‘‘ Dr. Robinson was a native of Guilford, Connecticut, born there in September, 1830. He was prepared by his father for Yale College, from which institution he graduated in his twenty-second year. In 1855 he was granted his degree of M. D. at the Medical Department at New Haven. After taking an additional course at the College of Physicians and Sur- geons, New York, he traveled in the West and engaged in medical prac- tice. He returned to New York and for a few years held the position of surgeon on one of the transatlantic steamship lines. During the war he served on the government transport McClellam and others. In 1865 he again resided in New York, and for several years occupied the position of medical examiner for the North American and other life-insurance compa- nies. In 1867 he married the only daughter of the late Dr. James H. Henry, of Brooklyn, in which city he has ever since resided. His wife, one son and one daughter, survive him. “. He died after a short illness, December 20, 1891. “Resolved, That this Association keenly regrets the untimely loss of their associate member, and will feel the absence of his sincere counsel and co-operation, and most feelingly sympathise with the members of his family in their sorrowful bereavement. [Signed] W. * §:º | Committee. The paper of the evening was by the Retiring-President, Dr. J. D. Rushmore, on “Anaesthesia with Ether.” STATED MEETING, MARCH 8, 1892. The President, Dr. J. D. Sullivan, in the chair. The paper of the evening was on “Approximate Estimation of Urea in Urine,” by Dr. E. R. Squibb. Dr. Charles A. Doremus and Dr. E. H. Bartley, as guests of the Associ- ation, discussed the paper. STATED MEETING, APRIL 12, 1892. The President, Dr. J. D. Sullivan, in the chair. The papers of the evening were “On the Treatment of Diabetes Melli- tus,” by Dr. H. C. Riggs, and an abstract of a paper of Hirschberg's on “Diabetic Retinitis,” by Dr. L. A. W. Alleman. 766 NEW YORK STATE MEDICAL ASSOCIATION. STATED MEETING, MAY 10, 1892. The President, Dr. J. D. Sullivan, in the chair. The papers of the evening were by Dr. W. H. Bennett on “Dust and a Polluted Atmosphere as Prime Factors in the Causation of Chronic Naso- Pharyngeal Catarrh : with some Remarks on Deviations of the Nasal Sep- tum and Treatment; ” and by Dr. E. R. Squibb, on “Solutions of Dioxide of Hydrogen or Peroxide of Hydrogen.” STATED MEETING, JUNE 14, 1892. The President, Dr. J. D. Sullivan, in the chair. Dr. Thomas H. Manley, of New York, read the paper of the evening on “The Therapeutic Value of the Mercurial Salts in General Surgery.” A vote of thanks was tendered by the Association to Dr. Manley for his valuable and interesting paper. STATED MEETING, NOVEMBER 9, 1892. After the summer intermission, and the omission of the regular October meeting because of the Columbus celebration, the Association held its fif- tieth stated meeting on Wednesday evening, November 9th. The President, Dr. J. D. Sullivan, in the chair. Dr. Adolph Wilber presented a specimen of a foetal sac thrown off by a woman two months pregnant, in which examination failed to detect a foetus. The paper of the evening was by Dr. T. M. Rochester, on “The After Treatment of Haemorrhage.” STATED MEETING, DECEMBER 13, 1892. The President, Dr. J. D. Sullivan, in the chair. Dr. Jonathan Wright read the paper of the evening on “Nasal Sprays and Douches.” T. M. ROCHESTER, M. D., President. H. C. RIGGS, M. D., Corresponding Secretary. NEW YORK COUNTY MEDICAL ASSOCIATION. ANNUAL REPORT. This report is respectfully presented to the State Association as a record of the scientific work of the organisation in the County of New York. The promotion of the science and art of Medicine, and the co-operation of the State and County organisations, are the objects desired in its presentation. IN THE DEPARTMENT OF SURGERY.—At the meeting October, 1891, DR. FREDERIC S. DENNIS presented some surgical cases of special interest. 1st.—A case of non-traumatic acute suppurative Osteo-myelitis. 2d.—One of non-traumatic acute suppurative arthritis of the knee-joint, of gomorrhoeal origin. 3d.—One of aneurysm of the iliac artery, with enormous distention of the limb. This was on the right side, and followed an aneurysm of the left popliteal artery which was cured by compression with an Esmarch bandage, the patient being under the influence of ether for one hour and a half. Dr. Dennis then described three cases of stab wound of the abdomen in which laparotomy was performed and recovery resulted. Finally he exhibited two cases of undescended testicle. In each a truss was worn, and it was hoped that the desired result would be obtained without a resort to operation. These several cases were brought in ambulances to the place of meeting, and, in lieu of discussion, Dr. Dennis's remarks in answer to the many questions of the members were most instructive and useful to all interested in surgery. At the meeting in December, 1891, DR. WON DONHOFF read a paper on “Tracheotomy Without the Use of the Tube.” The author said that for Seventeen years he had in ordinary cases performed tracheotomy without using the tube or canula. He did so to avoid the difficulties and dangers attending the introduction and removal of the canula. The opening into the trachea is kept open by ligatures—one on each side—which are fastened together behind the neck. Very little after management was required. The paper was discussed by Dr. Truax and others. At the meeting March 21, 1892, was presented the subject of “New Ideas in Bandaging,” by DR. DANIEL BROWN. The doctor demonstrated a Substitute for the ordinary roller bandage, which consisted of the applica- tion of cheese cloth stretched over sheets of cotton, which, with a large needle and coarse strong thread, was drawn snugly together ; if more 768 JWH’W YORK STATE MEDICAL ASSOCIATION. pressure is desired another Seam may be made with gores. In case of gathered breasts it may be made to fit neatly, and is capable of forming a very meat and comfortable jacket. One of the advantages of this bandage is that a nurse or unskilled helper could easily be instructed to apply it, and it is less likely to slip down than the roller bandage. It also allows of greater freedom of movement. At the meeting May 16, 1892, DR. THOS. H. MANLEY read a paper, being “A Few Notes on the Morbid Anatomy, Pathology and Treatment of Umbilical and Ventral Herniae of the Congenital and Acquired Types.” This paper was a very full and interesting description of the various con- ditions of which it treats, and of the choice of various lines of treatment. It was discussed by Drs. Milliken, Sayre, Von Donhoff, H. B. Tucker, and De Garmo. The discussion was closed by Dr. Manley. On the same evening, DR. S. E. MILLIKEN gave a short description of Bassini's operation for inguinal hernia. DR. A. B. JUDSON then read a paper on the subject of the “Treatment of Congenital Club-Foot.” Dr. Judson confined himself to the considera- tion of two or three important points, viz.: Early treatment, i.e., while in arms; the first twelve months are the most important in the history of the case. It should be placed in such a position that its own motion would tend to correct the deformity. In the apparatus an upright bar should be used, which may be bent as the foot gradually assumes the correct position. This paper was discussed by Drs. L. A. Sayre, S. E. Milliken, and Won Donhoff, and closed by Dr. Judson. In addition to these scientific subjects a paper was read by Dr. C. B. MEDING on the subject of “Physician Heal Thyself.” The characteristics of this paper may be better shown by reading some of its sentences. “Two factors are sureto force the medical profession to higher ground, whether it will or no—first, an universal mental advance; second, the growing strength of public opinion.” “Public opinion, a consequence and an index of public education, affects us in common with all others, by stripping the profession of every unearned honor.” “Every profession has had to change its basis, not, alas ! without the loss of many misled conservatives. Priests are now spiritual pastors, not confessors; lawyers are advisors, not pugi- lists; physicians must be teachers, not semi-magicians.” “But while med- icine is growing into the dignity of a science, we must not forget that it is, always has been, and ever will be an art. It is an art because it must be thought, and thinking is an art.” “Astronomy leaped when men hunted for stars of destiny; physics found advance in heat, light, water, Sound, and to-day in electricity, by exaggerated applications of the same to the body; chemistry is at present devoted to remedy seeking ; and the various studies of psychology, philosophy, etc., find their grandest use in appli- cation to disease. Then should not the physician be as capable a master 88 possible 2—remedies are slaves.” “Probably after this age of bacteriological research, surely some time in the future, will come the age of the study of the human mind.” PROCEEDINGS WEW YORK COUNTY ASSOCIATION. 769 “It is an age of advance; true, but all progress is not advance. ‘To ad- vance,’ says Emerson, “something of the old must forever mingle with the new,’ and that something is a thoughtful resumé, a brief but particular condensation. For the healing of ourselves, then, a considerate following of present demands; attention to the details of modern research and discovery without necessarily an absolute surrender to the same ; a wise moderation in praise, an ability to instruct, an education to prepare us for such duties.” “These are the medicines we need, and it is the duty of this—of every Society to urge, aye, to enforce the wholesale manufacture and wide dis- tribution of these remedies.” - “We must teach : Therapy is not the open sesamé to the glorious heaven of health, but knowledge ; not expressed in an incomprehensible terminology, but told in plain truth ; knowledge of right and wrong, of habit and surroundings, of the Hippocratean trio : air, water and places. Such is the golden gate to the throne of true greatness to which we of all men have a God-given right.” DISEASES OF THE Nos.E AND THROAT.—At the meeting November 16th, 1891, DR. J. W. GLEITSMAN read a paper on “A New and Simple Method of Lessening Reaction After the Use of the Galvano-Cautery for Nasal Hypertrophies.” The subject was thoroughly explained and illustrated, and the desirability of lessening reaction justified. This paper was dis- cussed by Drs. Quinlan, Tyndale, Friedenburg, and Mac Gregor, and closed by Dr. Gleitsman. DISEASES OF THE EYE were presented in two papers, one by DR. OPPEN- HEIMER, at the same meeting. Subject : “Sympathetic Ophthalmia and Other Causes of Permanent Blindness.” The author of the paper presented statistics of blindness in different parts of the world, and especially as ap- plied to the city of New York. Much could be done by the general prac- titioner in giving due attention to injury or disease of one eye before the Other became affected. The paper was of great practical importance, and was discussed by Drs. Hepburn, Friedenburg, Wan Fleet, Agramonté, Cocks, and the Chair, and discussion was closed by Dr. Oppenheimer. At the meeting April 18th, 1892, DR. N. J. HEPBURN read a paper on “Foreign Bodies in the Eye.” This paper was brief, but comprehensive. “If foreign bodies are loosely attached to the conjunctiva or cornea, a probe armed with a piece of cotton will usually bring it away. If it be firmly attached, a needle or sharp pointed instrument will be required. If the particle should be sharp, or hot, it becomes serious, and removal is difficult. Attempts at extraction should be preceded by the application of a few drops of a two per cent. solution of cocaine. If firmly embedded, it should be drawn out with forceps. When it enters the eyeball it becomes more serious, and its removal requires the careful consideration of the ophthalmic surgeon. The electro-magnet may also play an important part.” * 770 ME}|W YORK STATE MEDICAL ASSOCIATION. SKIN DISEASE.-At the meeting December 21st, 1891, a paper was read by DR. L. DUNCAN BULKLEY on the “Non-Contagiousness of Leprosy.” In this paper the history, diagnosis and etiology were all taken into con- sideration with a view of showing its relation to contagion. The author concluded with presenting the following results of his study : “1. There is no warrant for the popular terror surrounding the name ‘leprosy' as a disease. 2. The disease is not contagious in the ordinary acceptation of the term as applied to such diseases as smallpox, Scarlatina or syphilis. 3. Leprosy is probably due to the presence of a bacillus. 4. There is strong reason to suspect that it may first be introduced into the system by food, and especially fish. 5. There is evidence that when acquired the dis- ease may, under favorable conditions, be transferred from one person to an- other. 6. Heredity probably accounts for a share of the cases, but the dis- ease is not necessarily transmitted by inheritance. 7. Inoculation with leprous matter may be the means of conveying the disease when all the conditions are favorable. 8. There are far more and greater reasons for the restriction of syphilis and tuberculosis by isolation and segregation, than for the necessity of these regulations in regard to leprosy.” This paper was discussed by Drs. Fernandez, L. S. Seaman, J. H. Tyndale, and closed by Dr. Bulkley. PRACTICE of MEDICINE.—At the meeting February 15th, 1892, DR. AUSTIN FLINT read a paper on “Urinary Analysis,” exhibiting a portable case for clinical examination of urine. Dr. Flint showed the utility of the case by testing several samples of urine for albumen, sugar, etc. He said that if an absolutely reliable test was required, the urine for examination should be gathered for at least twenty-four hours. He then gave a number of tests approximately reliable in every case of urinary analysis. The principal advantage of the apparatus was that within a few minutes an analysis could be made at the bedside. Discussion by Drs. H. M. Biggs and C. A. Doremus. In connection with the discussion, Dr. Joseph N. Henry exhibited two specimens of urine, from two separate patients, which were colored by the internal administration of methylene blue for the relief of chronic bladder disease. - On March 21st, 1892, DR. J. LEWIS SMITH presented the subject of “Recent Investigations relating to the Prevention of Diphtheria and Scarlet Fever.” Dr. Smith related many interesting facts in connection with the contagiousness of these diseases. He believes it always originates from the presence of a specific microbe, and while relying on throat disinfection, he has little faith in sulphur for that purpose. A strong solution of corrosive sublimate or a five per cent. Solution of carbolic acid, is better. When ex- amining the patient the physician should place himself either to one side or behind, not in front. While smallpox is thoroughly controlled in this city, it is impossible to gain the same control of these two diseases. This paper was discussed by Drs. Leale, Tyndale, Nye, and Koplik. PROCEEDINGS WEW YORK COUNTY ASSOCIATION. 771 At the April meeting a paper was read by DR. J. HILGARD TYNDALE on “Chronic Adhesive Pleurisy, Inflammatory and Tubercular.” “All pathological conditions in the lung, other than tumors and surgical lesions, can be classed under two headings, viz.: mechanical hindrances to respira- tion, and tubercular infiltration.” The paper was taken up with the various conditions occurring, and with the treatment, which consists of three parts, viz.: 1. Internal remedies. 2. Hypodermic medication. 3. Surgical procedures. These three are the same whether the disease is inflammatory or tubercular. Iodine and mercury, sodium salicylate, arsenic and the hypophosphites are internal remedies. Iodine is best for hypodermic use. The paper was discussed by Drs. Gibier, Leale, White, and J. G. Truax, and closed by Dr. Tyndale. On June 20th, 1892, DR. J. BLAKE WHITE presented a paper entitled, “Observations on the Hypodermic Use of Gold and Manganese in Tuber- culosis, with Reports of Cases.” The author of this paper gave very strong reasons for his estimate of the value of these remedies, and expressed him- self thus: “If we have, as my experience leads me strongly to believe, antidotal remedies in the preparations of gold and manganese, we are approaching that much desired stage in the therapeutics of tuberculosis when we can look with greater certainty to masterful aid from medicine in combating this dread destroyer of human life.” This paper was dis- cussed by Drs. MacGregor, Tyndale, and F. J. Quinlan, and closed by Dr. White. OBSTETRICS.—At the same June meeting a paper was read by DR. T. J. McGILLICUDDY, entitled “Notes on Conservative Obstetrics, with Exhibition of New Instruments.” The instruments presented were Dr. McGillicuddy's traction forceps and anti-craniotomy forceps. The author of the paper spoke of conservative in contra-distinction to destructive midwifery, and explained in eatenso the modus operand of his forceps. With this, he stated some cases where they proved useful in saving the lives of children. DR. BELL, of Glasgow, Scotland, being present, was invited by the President to take a seat upon the platform and to open the discussion, which he did. After this, the discussion was continued by Drs. Geo. T. Harrison, James Stafford, C. A. Von Ramdohr, and C. D. Meding. Discus- sion was closed by Dr. McGillicuddy. At the meeting May 16th, 1892, the subject of “Nervous Disease” was treated of in a paper by DR. R. HARCOURTANDERSON, on “Graphospasmus, or ‘Writer's Cramp.’” The author described several varieties. He considered that the subject had not received from the profession the attention it deserved, and that its presence was an evidence of reduced witality, and might be the precursor of serious trouble in the nervous system ; he believed the source of the trouble was in the cerebellum. After defining several plans of treatment, he exhibited an apparatus which he had devised, and by means of which the affected muscles could be rested. 49 772 NEW YORK STATE MEDICAL ASSOCIATION. It may thus be seen that in the form of papers and discussions thereon we have had formal dissertations on “Surgery ; ” “Diseases of Throat and Nose; ” “Skin ; ” “Practice of Medicine ; ” “Obstetrics,” and “Nervous Disease.” In addition to these, pathological specimens have been shown at almost every meeting. Specially among these may be noticed two specimens presented by DR. THos. H. MANLEY — one from a case of inguinal hernia, and one from a ventral hernia in a female suffering from uterine fibroids. A specimen was presented by DR. Von DoNHoFF, i.e., a benign tumor of the breast, a result of mastitis. This tumor he lately removed. After removal, the neighboring glands, which had become enlarged, regained their usual size ; and the patient's general health, which had been deterio- rated, was fully restored. A specimen was presented by DR. Dw1GHT L. HuBBARD,-a “mon- strosity’ delivered at eight months, in which there was a lack of develop- ment of pelvic and external genitals, and with undivided lower extremities. It may not be uninteresting to know something of the working of an Association aside from that which is strictly scientific. At the meeting October 19, 1891, on motion of DR. NoLL, the following resolution was adopted, viz.: Resolved, That it is the sense of the New York County Medical Associa- tion, that the Legislature of this State should secure all land constituting the Adirondacks for a State park, acquiring such land either by purchase or condemnation proceedings; and be it further l Itesolved, That a copy of these resolutions be transmitted to the Legis- ature. These resolutions were duly sent to the Legislature by the Secretary. The Association has also appointed a Committee on Legislation, consist- ing of DRS. T. H. MANLEY, A. D. RUGGLEs, and S. S. PURPLE. DR. C. A. LEALE, President of St. John's Guild, invited the members to send patients, where parents were too poor to pay for medical attendance, to the New York Hospital for Sick Children, opened by the Guild at 157 West Sixty-first street. This was heartily approved, and commended to the attention of all. Transmitting the request of the Grant Monument Association that the medical profession should join in making contributions, the President made the announcement and requested co-operation, which was cheerfully given. At the request of the President, DR. MANLEY made a report in regard to the recent meeting of the American Medical Association in Detroit, and suggested the preparation of a statement in regard to the representation of the profession in New York State in the Association. DR. FERDINAND KING, editor of the Doctor's Weekly, kindly offered to send a copy of such statement to every member in the State. DRS. TRUAX and MANLEY were appointed as a committee to prepare the statement, which was done. PROCEEDINGS NEW YORK COUNTY ASSOCIATION. 773 The meeting in January is devoted to the election of officers and the reading of annual reports. At that meeting the following officers were elected : President, S. B. W. McLEOD, M. D.; Vice-President, WM. T. WHITE, M. D.; Corresponding Secretary, AUGUSTUs D. RUGGLEs, M. D.; Record- ing Secretary, P. BRYNBERG PortER, M. D.; Treasurer, JoBN H. HINTON, M.D.; Member of Executive Committee, Won BEVERHOUT THOMPSON, M.D. At the February meeting the President, DR. McLEoD, delivered the annual address. The general subject of the address was : “The Difficul- ties Attending the Practice of Medicine at the Present Time, and the Duties of the Physician in View of These.” After enumerating some of the diffi- culties, the address closed with an exhortation to the members of this Association to unite heartily in the performance of the great work before the medical profession of the United States. The Association continues to increase and harmony to prevail. The membership at the end of June, 1892, was eight hundred and nine (809). We feel it to be our duty to the living to report our progress, and strive for still greater results. To the dead—to honor their memory and place on record their unforgotten names. DRs. GOODMAN, DAMAINVILLE, BEDFORD, HILTON, EMBREE, MooRE, MAURY, MOLLER, SEARING, SMITH, DONLIN, and TAYLOR, have served their day and generation, and left the world in peace and hope. S. B. W. McLEOD, President. PROCEEDINGs. NINTH ANNUAL MEETING OF THE NEW YORK STATE MEDICAL ASSOCIATION, HELD AT THE MOTT MEMORIAL HALL, 64 MADISON AVENUE, NEW York CITY, NovKMBER 15, 16, and 17, 1892. FIRST DAY, TUESDAY, Nov. 15, 1892. MORNING SESSION. The meeting was called to order at 10.30 A.M., by the PRESIDENT, DR. JUDSON B. ANDREws, of Erie county, The report of the Committee of Arrangements was presented by the Chairman, D.R. JoHN G. TRUAx, and, upon motion, it was accepted and adopted. (See page 15.) The SECRETARY then moved the postponement of the President's Address until after the routine business had been transacted. Carried. The annual report of the Council was then read by the SECRETARY. On motion, the report of the Council was received and adopted. The SECRETARY moved, in accordance with a communication in the report of the Council, that a committee of five be appointed to meet a committee of the American Medical Association ; this committee to be appointed by the PRESIDENT during the present session. Carried. The SECRETARY then moved that a committee of three be appointed by the PRESIDENT to report before the close of this meeting upon some plan relative to the creation of a delegateship for affiliated organisations in the State of New York. He said that this would result in increasing the number of delegates who would be sent from the State to the American Medical Association. Carried. The reports of the various District Associations were then read by title. PROCEEDINGS. 775 AFTERNOON SESSION. The meeting was called to order by the PRESIDENT. The SECRETARY announced the appointment of the following Nomi- nating Committee : First District, DR. Doug LAs AYREs, DR. A. P. DoDGE. Second District, DR. E. M. Lyon, D.R. G. R. MARTINE. Third District, DR. GEORGE Doug LAs, DR. JAMES HENCHLEY. Fourth District, DR. T. D. STRONG, DR. F. H. Moy ER. Fifth District, DR. J. W. S. GoulBy, DR. R. C. WAN Wyck. At large, DR. JOHN CRONYN. EVENING SESSION. The evening was occupied with the reading of scientific papers. SECOND DAY, WEDNESDAY, Nov. 16, 1892. MORNING SESSION. The meeting was called to order by the PRESIDENT. The following committee was appointed by the PRESIDENT to meet a similar committee from the American Medical Association : DR. E. M. MOORE. DR. D. COLVIN. DR. M. W. TownsEND. DR. J. G. TRUAX. - DR. E. D. FERGUSON. The PRESIDENT appointed the following committee to consider the creation of a delegateship for affiiliated organisations in the State : DR. A. L. CARROLL. DR. T. D. STRONG. DR. E. D. FERGUSON. The following committee to examine the TREASURER's accounts was ap- pointed : DR. DOUGLAS AYRES. DR. JoBIN CRONYN. DR. WILLIAM GOVAN. AFTERNOON SESSION. The meeting was called to order at 2 P. M. by the WICE-PRESIDENT, DR. L. J. BROOKs. The session was devoted to the reading and discussion of scientific papers. EVENING SESSION. This session was opened by the delivery of the “Address on Surgery,” by DR. FREDERIC S. DENNIS, of New York County. After the reading and discussion of a paper by DR. H. D. DIDAMA, the Association ad- journed to partake of a collation. 776 NEW YORK STATE MEDICAL ASSOCIATION. THIRD DAY, THURSDAY, NovKMBER 17, 1892. MORNING SESSION. The meeting was called to order by the PRESIDENT. The SECRETARY presented the report of the Nominating Committee. Report of the Nominating Committee. For President : S. B. W. McLEOD, of New York County, Fifth Dis- trict. For Vice-Presidents : R. N. CooDEY, Oswego County, First District. J. C. HANNAN, Rensselaer County, Second District. N. JAcobson, Onondaga County, Third District. Z. J. LUSK, Wyoming County, Fourth District. For Secretary and Treasurer : E. D. FERGUSON, Rensselaer County. For Chairman of the Library Committee : J. W. S. Gouley, New York County. For Members of the Council : First District, A. P. DoDGE, Oneida County. Second District, J. B. HARVIE, Rensselaer County. Third District, M. CAVANA, Madison County. Fourth District, F. H. MoyFR, Livingston County. Fifth District, A. L. CARROLL, New York County. The PRESIDENT-ELECT appointed JoHN SHRADY, New York County, as member of the Council at large. Upon motion, this report was accepted. It was moved and seconded that the SECRETARY be instructed to cast an affirmative ballot for the list of officers as read. Carried. These gentlemen were then declared elected. It was moved and seconded that the members of the committee appointed to meet the committee of the American Medical Association, be empowered to appoint alternates in case of their inability to attend. Carried. DR. J. LEWIS SMITH, of New York County, presented an invitation from the New York Foundling Asylum for the Association to inspect that institution any day during the week of meeting, between the hours of two and four in the afternoon. The Committee on By-Laws made the following report : It is suggested that ARTICLE II., Section 6, of the Constitution, should be amended as follows: In addition to the foregoing Fellows of the Association, delegates not being Fellows of the New York State Medical Association may be sent from medical organisations throughout the State in affiliation with this Association, in the proportion of one delegate for each ten members of said PROCEEDIWGS. 777 subordinate organisation. Such delegates shall serve for the annual meet- ing next succeeding their appointment; they shall be entitled to vote on all questions not involving a change of the Constitution and By-Laws, and shall not be chargeable with any fee or due, though they may secure a copy of the Transactions of the meeting at which they served, at the cost of extra copies to regular Fellows. No medical organisation can be entitled to send delegates unless its Constitution and By-Laws are in harmony with those of the State Association, the same having been approved by the Council of this Association; nor shall it be subordinate to any other State medical organisation. - Under the rules, no action can be taken on this report until the nex annual meeting. AFTERNOON SESSION. The meeting was called to order by the PRESIDENT. The Committee on Treasurer's Accounts reported that they had ex- amined the same and found them correct. On motion, the report was accepted. After the reading and discussion of the papers, the PRESIDENT, DR. ANDREWs, expressed his thanks for the courtesy exhibited by the Associa- tion to him, and the honor conferred upon him, both of which he should never forget. He then introduced the newly-elected PRESIDENT, DR. S. B. W. McLEOD, of New York County. DR. McLEOD expressed his regret at seeing DR. ANDREWS retire from the Chair, and that this interesting meeting should so soon have come to a close ; nevertheless, he said, in the process of evolution, even presiding officers must change, and while it had been the retiring President's pleas- ant duty to see the members assemble and to bid them welcome, it was his less pleasant duty to see them disperse and to bid them farewell. The minutes were then approved. On motion of the SECRETARY, the ninth annual meeting of the Association was declared adjourned. E. D. FERGUSON, Secretary. ANNUAL REPORT OF THE COUNCIL, AND MINUTES OF THE SESSIONS OF THE COUNCIL, FOR THE YEAR 1892. The ninth annual meeting of the Council was held in its rooms in the Mott Memorial Library, on Tuesday evening, November 14, 1892. The meeting was called to order by the Secretary at 8.30 P. M. Present : Drs. Brooks, Carroll, Douglas, Ferguson, Gouley, Harvie, Jewett, McCollom, Strong, Truax, Van Hoevenberg, and Wilson. In the absence of the President, Dr. Van Hoevenberg, Vice-President for the Fifth District, took the Chair. The Secretary reported the following applicants for Fellowship in the Association, as having been appointed by circular vote since the last meet- ing of the Council, viz.: W. B. Webster, Michael F. Phelan, John L. Andrews, Henry Smith Williams, A. Reading Gulick, Charlton R. Gulick, Joseph E. Baynes, John E. Weeks, Leonard S. Rau, W. B. De Garmo, M. Christopher O’Brien, F. H. Daniels, Wm. E. Swan, Andrew T. Weeder, John F. Fitzgerald, John C. Fisher, Thomas P. Scully, J. O. Davis, J. S. Parent, Charles F. Town- send, Electra B. Whipple, Allen A. Jones, Bernard Cohen, W. H. Berg- told, Percy Bryant, Charles F. Howard, H. C. Abrams. The following applicants were appointed Fellows, viz.: Franklin D. Clum, Clarence G. Campbell, Eden W. Delphey. The Treasurer then submitted his annual report as follows, viz.: The Treasurer is gratified to be able again to show an increase in the balance in the treasury, the net increase in the funds of the Association amounting to $692.10, being a somewhat larger increase than was made the year before. Nearly $500 was collected from those in arrears for dues of two or more years, and dues were paid by quite a number who had re- *Ceived remission for arrears for illness or financial embarrassment, a fact which is very gratifying to the Treasurer and creditable to the Association. While the events for the future do not admit of prophecy, the Treasurer is persuaded that there are good grounds to anticipate a still more favor- able showing at the next annual report, but he feels the importance of a continuance for some time of the plan of accumulating a reserve fund. AWWUAJ, REPORT OF THE COUNCIL, 779 ANNUAL REPORT OF THE TREASURER FROM OCTOBER 15, 1891, To NovKMBER 1, 1892. BECEIPTS-GENERAL FUND. Balance from last report, . . . . . . . . . . $1,085.01 Dues, . . . . . . . . . . . . . . . . 2,733.00 Initiation fees, . . . . . . . . . . . . . 180.00 Sale of Transactions, . . . . . . . . . . . 80.00 —— $4,078.01 - DISBURSEMENTS. Sundries, including printing the Transactions, . . $2,232.60 Postage stamps, . . . . . . . . . . . . . 99.41 Expressage and freight, . . . . . . . . . . 68.89 —— 2,400.90 Balance in the general fund November 1, 1892, . . . . $1,677.11 LIBRARY AND BUILDING FUND. Balance from last report, . . . . . . . . . . $2,482.41 Interest, , , . . . . . . . . 100.00 — 2,582.41 Total funds in treasury November 1, 1892, . . . . . $4,259.52 The report of the Treasurer was accepted and approved. On motion, the Secretary and Treasurer were authorised to remove from the list of Fellows such names as persistently and without adequate reason neglected to pay arrears of dues. The Secretary then presented the REPORT OF THE COMMITTEE ON PUBLICATIONS. Volume 8 of our Transactions, containing 780 pages of printing, was issued within a reasonable time after the closing of our annual meeting, and, though a few typographical errors, as in paging, etc., escaped the proof-reading of the editor and the printer, still, on the whole, it is felt, in view of the rapidity with which the work was done and the many things to do, that indulgence can be asked and expected for the defects. The increased size of the volume added over $200 to the expenses con- nected with the printing and distribution, but fortunately the treasury was able to meet that increase without a diminution of its met balance. The subscriber, while glad to have been able to discharge the duties and receive the honor of the editorship of the Transactions, feels that his strength will not allow of his undertaking the work for the ensuing year. [Signed] E. D. FERGUson, Chairman. The Secretary then read the EIGHTH ANNUAL REPORT OF THE LIBRARY COMMITTEE OF THE NEW YORK STATE MEDICAL ASSOCIATION. Movember 14, 1892. This eighth annual report of the Library Committee indicates an in- crease of ninety-one (91) volumes. The number of volumes given in the 780 NEW YORK STATE MEDICAL ASSOCIATION. last report being eight thousand nine hundred and twenty-one, this addi- tion of ninety-one (91) volumes makes a total of nine thousand and twelve (9,012) volumes at present in the library, which is open to the Fellows of the Association, to other physicians, to medical students, and to non- medical persons. J. W. S. Gouley, M. D., Director of the Library and Chairman of the Library Committee. On motion, the report was accepted and adopted. NOTES BY THE SECRETARY. Since our last annual meeting certain events have occurred regarding our relations to the American Medical Association, which, in some partic- ulars are only matters of history now, and do not call for comments on our part other than to commend the judicious and truly conservative action of the national organisation on what seems to us as fundamental principles in its own and our plan of constitution. In connection with the appointment of delegates to the American Medical Association, it became necessary this year for me to emphasise the fact that our Association is the only medical organisation in the State of New York entitled to representation in that body. While our doors are open to all regular physicians who would be qualified to act as delegates, still it may not be good taste or even justice on our part to insist that no other means shall exist, if it can be done with a proper care for the interests of all concerned. The only method would be the creation of a system of representation in the State Association on the part of local organisations in affiliation with us—as the King's County and New York County Associa- tions, they being authorized to send delegates in a certain proportion to their membership, and from those not already Fellows of the State Asso- ciation. Such delegates can have full or limited rights during the year of delegateship in the State Association, but such privilege would give the local organisations authority to send delegates to the American Medical Association. I would suggest that the subject be referred to a committee to report at present meeting of the Association. On motion, the suggestion of the Secretary in reference to the proposal to provide for delegates from organisations within the State in affiliation with the State Association, was approved, and the subject was referred to the Secretary to suggest a plan of procedure. The following communication from the Permanent Secretary of the American Medical Association was read, viz.:- DEAR DOCTOR: At the session held in Detroit, June, 1892, it was Resolved, That a committee of five be appointed by the President of this Association, who shall be instructed to meet a like committee from the State Medical Society of New York, and the State Medical Association of New York, for the purpose of adjusting all questions of eligibility of members of said State Medical Society of New York, to membership in this Association; said committee to report at the next annual meeting of this Association. Yours truly, WM. B. ATKINSON. Please acknowledge. A WNUAL REPORT OF THE COUNCIL. 781 Committee: N. S. DAVIs, Chicago; JoHN H. RAUCH, Chicago; WM. T. BRIGGS, Nashville; DUDLEY S. REYNoLDs, Louisville; WILLIs P. KING, Kansas City. The following communication was then read : PHILADELPHIA, May 20, 1892. DEAR SIR : At our session held this day in Harrisburg, the following resolutions were adopted : Resolved, That the Medical Society of the State of Pennsylvania hereby expresses its highest disapprobation of the practice of giving certificates or testimonials to secret preparations alleged to be of medicinal virtue, and calls the attention of the affiliated county societies to the fact that such action on the part of members of the said societies is in derogation of the dignity of the profession, and in violation of the letter and the spirit of the Code of Ethics of the American Medical Association and of this Society. Resolved, That this Society likewise expresses its disapprobation of the practice of inserting advertisements of secret preparations in the columns of medical journals, such action being an insult to the intelligence of the profession, and a degradation of journals indulging therein to the level of the patent medicine almanac. Especially to be condemned is the action of the Journal of the American Medical Association in admitting such adver- tisements. ReSolved, That copies of these resolutions, duly attested by the Per- manent Secretary, be sent to all county societies in affiliation with this Society, to the American Medical Association, to State medical societies in affiliation therewith, and to the publishers and editors of American medical journals. Yours respectfully, WM. B. ATKINSON, Permanent Secretary. On motion, the foregoing resolutions were indorsed. A communication from the Fless & Ridge Printing Co., relative to the printing of the Transactions, was received, and referred to the Committee on Publications with power relative to the proposal. Drs. James B. Murdock and James McCann, of Pittsburgh, Pa., were nominated for non-resident Fellowships by Drs. Gouley, Carroll, and Truax, and, on motion, they were appointed. A bill of Angell's Printing Office, to the amount of $73.83, for printing the Programme, was then audited, and the Treasurer directed to pay the S8, D16. On motion, the Council adjourned, after approving the minutes. E. D. FERGUSON. Secretary. The new Council met in its room in the Mott Memorial Library, at 4 P. M., on Thursday, November 17, 1892. Present : the President, Dr. McLeod, and Drs. Carroll, Cavana, A. P. Dodge, Ferguson, Gouley, Hannan, Z. J. Lusk, Moyer, Strong, and Truax, 782 NEW YORK STATE MEDICAL ASSOCIATION. On motion, the members of the Council for the Fifth District were con- stituted the Committee of Arrangements for the next Annual Meeting, with power to add to their number. On motion, the sum of $100 was directed to be added this year to the $100 which the Association gives annually to the Trustees of the Mott Memorial Library. - The following applicants were appointed Fellows, viz.: Frank R. Baker, John T. Cahill, Charles E. Congdon, E. G. Drake, George A. Him- melsbach, O. A. Holcomb, James F. Huntley, Dennis L. Shea, John Eliot Shrady, Won Beverhout Thompson, J. C. Wanderveer, Frederick Holme Wiggin. The members of the Council for the Fifth District were appointed the Committee on Publications, with Dr. O. C. Ludlow as Editor of the Transactions, and the Secretary was authorised to expend $100 in editorial work connected with the printing of the Transactions. A bill of the Angell Printing House for $7.50 was audited and approved. After approving the minutes of the session, the Council adjourned. E. D. FERGUSON, Secretary. LIST OF FELLOWS. BY DISTRICT AND COUNTY. FIRST OR NORTHERN DISTRICT. FRANKLIN COUNTY. Founder. Gillis, William. Fort Covington. 1 |FULTON COUNTY. Original. Blake, Clarence R. Northville. Founder. de Zouche, Isaac. Gloversville. Drake, D. Delos. Johnstown. Edwards, John. Gloversville. 4 HAMILTON COUNTY. McGann, Thomas. Wells. 1 HERRIMER COUNTY. Casey, J. E. Mohawk. Douglass, A. J. Ilion. Garlock, William D. Little Falls. Original. Glidden, Charles H. Little Falls. Green, H. H. Paine's Hollow. Original. Potter, Vaughan C. Starkville. Original. Sharer, John P. Little Falls. Original. Southworth, Mark A. Little Falls. Original. Young, John D. Starkville. 9 784 NEW YORK STATE MEDICAL ASSOCIATION. Founder. Founder. Original. Original. Original. Original. Original. Founder. Original. Original. Original. Original. Original. JEFFERSON COUNTY. Abell, Ira H. Antwerp. Crawe, J. Mortimer. Watertown. Johnson, Parley H. Adams. w 3 LEWIS COUNTY. Crosby, Alexander H. Lowville, Douglass, Charles E. Lowville. Joslin, Albert A. Martinsburgh. Kelly, John D. Lowville. Kilborn, Henry F. Crogham. 5 MONTGOMERY COUNTY. Ayres, Douglas, Fort Plain. Caldwell, Nathan A. Hageman's Mills. French, S. H. Amsterdam. Graves, Ezra. Amsterdam. Johnson, Richard G. Amsterdam. Klock, Charles M. St. Johnsville. Leach, H. M. Charlton City, Mass. Parr, John. Buel. Parsons, W. W. D. Fultonville. Robb, William H. Amsterdam. Rulison, Elbert T. Amsterdam. Simons, Frank E. Canajoharie. Smyth, Arthur W. H. Amsterdam. 13 ONEIDA COUNTY. Armstrong, James A. Clinton. Babcock, H. E. New London. Bagg, Moses M. Utica. Barnum, D. Albert. Cassville. |Blumer, G. Alder. Utica. Bond, George F. M. Utica. Booth, Wilbur H. Utica. Brush, Edward N. Towsen, Md. Churchill, Alonzo. Utica. Clarke, Wallace. Utica. Dodge, Amos P. Oneida Castle. LIST OF FELLOWS. 785 Douglass, James W. Booneville. Ellis, J. B. Whitesborough. English, G. P. Booneville. Flandrau, Thomas M. Rome. Fraser, Jefferson C. Ava. Fuller, Earl D. Utica. Gibson, William M. Utica. Holden, Arthur L. Utica. Original. Founder. Original. Hughes, Henry R. Clinton. Hunt, James G. Utica. Euhn, William. Rome. Munger, Charles. Knoxboro. Nelson, William H. Taberg. Palmer, Henry C. Utica. Palmer, Walter B. Utica. Phelps, George G. Utica. Porter, Harry N. Washington, D. C. Quin, Hamilton S. Utica. Reid, Christopher C. Rome. Hussell, Charles P. Utica. Scully, Thomas P. Rome. Sutton, H. C. Rome. Sutton, Richard E. Rome. Swartwout, Leander. Prospect. Tefft, Charles B. Utica, West, Joseph E. Utica. *West, M. Calvin. Rome. 38 OSWEGO COUNTY. Bacon, Charles G. Fulton. IBates, Nelson W. Central Square. Cooley, F. L. Oswego. Cooley, R. N. Hannibal Centre. DeWitt, Byron. Oswego. Huntington, John W. Mexico. Johnson, George P. Mexico. Marsh, E. Frank. Fulton Todd, John B. Parish. 9 ST. LAWRENCE COUNTY. Cook, Guy Reuben. Louisville. 1 * Deceased. 786 NEW YORK STATE MEDICAL ASSOCIATION. Founder. Founder. Founder. Original. Founder. Founder. SECOND OR EASTERN DISTRICT. ALBANY COUNTY. Abrams, H. C. Newtonville. Bailey, Theodore P. Albany. Haynes, John U. Cohoes. Peters, Samuel. Cohoes. Rulison, L. B. West Troy. Sabin, William B. West Troy. Van Vranken, Adam T. West Troy. Witbeck, Charles E. Cohoes. Zeh, Merlin J. West Troy. 9 CLINTON COUNTY. Dodge, Lyndhurst C. Rouse's Point. Holcomb, O. A. Plattsburgh. Lyon, E. M. Plattsburgh. 3 COLUMBIA. COUNTY. Original. Benham, John C. Hudson. Bradley, O. Howard. Hudson. Clum, Franklin D. Cheviot. Fritts, Crawford Ellsworth. Hudson. Original. Lockwood, J. W. Philmont. Original. Smith, H. Lyle. Hudson. Wedder, George W. Philmont. Wheeler, John T. Chatham. Founder. Wilson, Thomas. Claverack. Woodruff, R. Allen. Philmont. Woodworth, T. Floyd. Kinderhook. 11 ESSEX COUNTY. Founder. Barton, Lyman. Willsborough. Church, Charles A. Bloomingdale. Original. D'Avignon, Francis J. Au Sable Forks. Original. LaBell, Martin J. Lewis. Original. *Pollard, Abiathar. Westport. Original. Rand, Hannibal W. Keene. Original. Riley, Andrew W. Au Sable Forks. Original. Robinson, Ezra A. Jay. Original. Turner, Melvin H. Moriah. 9 * Deceased. LIST OF FELLOWS. 787 Original. Original. Original. GREENE COUNTY. Conkling, George. Durham. Getty, A. H. Athens. Howland, George T. Athens. EIuestis, W. B. Kiskatom. Selden, O. G. Catskill. Selden, Robert. Catskill. 6 RENSSELAER COUNTY. Original. Founder. Original. Founder. Original: Founder. Founder. Original. Founder. Founder. Founder. Founder. Original. Original. Original. Original. Founder. Founder. Founder. Original. Allen, Amos. Grafton Centre. Allen, Charles S. Greenbush. Allen, William L. Greenbush. Baynes, Joseph E. Troy. *Baynes, William T. Troy. Bissell, James H. Troy. Bonesteel, H. F. Troy. Bonesteel, William N. Troy. Bontecou, Reed B. Troy. Boyce, Elias B. Averill Park. Burbeck, Charles H. Troy. Burton, Matthew H. Troy. Cahill, John T. Hoosick Falls. Cooper, William C. Troy. Crounse, Andrew C. Melrose. Dickson, Thomas Gordon. Troy. Ferguson, E. D. Troy. Finder, William. Troy. Greenman, C. E. Troy. Hannan, James C. Hoosick Falls. Harvie, J. B. Troy. Heimstreet, Thomas B. Troy. Houston, David W. Troy. Hull, William H. Poestenkill. Keith, Halbert Lyon. Upton, Mass. *Lamb, Milton M. Lansinburgh. Lyon, George E. Troy. Lyons, Edward L. Troy. Magee, Daniel. Troy. Marsh, James P, Troy. Mitchell, Howard E. Troy. Nichols, Calvin E. Troy. Nichols, William H. West Sand Lake. Phelan, Michael F. Troy. Rogers, S, Frank. Troy. * Deceased. 50 788 NEW YORK STATE MEDICAL ASSOCIATION. Founder. Founder. Original. Original. Founder. Founder. Original. Original. Founder. Original. Founder. Original. Founder. Original. Original. Founder. Original. Original. Rousseau, Zotique. Troy. Seymour, W. Wotkyns. Troy. Skinner, Smith A. Hoosick Falls. Tompkins, Fred J. Lansingburgh. Traver, Richard D. Troy. Ward, R. H. Troy. - 41 SARATOGA, COUNTY. Allen, Henry J. Corinth. *Babcock, Myron N. Saratoga Springs. Comstock, George F. Saratoga Springs. Crombie, Walter C. Mechanicsville. Curtis, P. C. Round Lake. Dunlop, John J. Waterford. Gow, Frank F. Schuylerville. Grant, Charles S. Saratoga Springs. Hall, William H. Saratoga Springs. Hewitt, Adelbert. Saratoga Springs. Hodgman, William H. Saratoga Springs. Hudson, George. Stillwater. Humphrey, J. F. Saratoga Springs. Inlay, Erwin G. Conklingville. Johnson, Ianthus G. Greenfield Centre. Keefer, Charles W. Mechanicsville. Kniskern, A. C. Mechanicsville. McEwen, Robert C. Saratoga Springs. Moriarta, D. C. Saratoga Springs. Murray, Byron J. Saratoga Springs. Palmer, F. A. Mechanicsville. Parent, J. S. Birchton. Preston, John R. Schuylerville. Reynolds, Tabor B. Saratoga Springs. Rice, George. Mechanicsville. Sherer, John D. Waterford. Sherman, F. J. Ballston. Smith, F. A. Corinth. Stubbs, Roland H. Waterford. Swan, William E. Saratoga Springs. Swanick, A. A. Saratoga Springs. Sweetman, J. T., Jr. Ballston. Thompson, Amos W. Saratoga Springs Warney, Miles E. Saratoga Springs. Webster, W. B. Schuylerville. Zeh, Edgar. Waterford. 36 * Deceased. IIST OF FELLOWS. 789. Original. Original. Original. Original. Original. SCHENECTADY COUNTY. Fuller, Robert. Schenectady. Hammer, Charles. Schenectady. McDonald, George E. Schenectady. McDougall, R. A. Duanesburgh. Reagles, James R. Schenectady. Van Zandt, Henry C. Schenectady. Weeder, Andrew T. Schenectady. 7 SCEIOHARIE COUNTY. Hagadorn, William. Gilboa. Ringsley, Henry F. Schoharie. 2 WARREN COUNTY. Original. *Ferguson, James. Glens Falls. Original. Fitzgerald, David J. Glens Falls. Martine, Godfrey R. Glens Falls. 3 WASEHINGTON COUNTY. Lambert, John. Salem. Long, Alfred J. Whitehall. 2 THIRD OR CENTRAL DISTRIOT. BROOME COUNTY. Founder. Original. Original. Allen, S. P. Whitney's Point. Chittenden, Joseph H. Binghamton. Dudley, Dwight. Maine. Ely, Henry Oliver. Binghamton. Farnham, Le Roy D. Binghamton. Farrington, John M. Binghamton. Forker, Frederick L. Binghamton. Fitzgerald, John F. Binghamton. Greene, Clark W. Chenango Forks. Hills, Lyman H. Binghamton. Hough, F. P. Binghamton. Ingraham, Charles W. Binghamton. Enapp, W. H. Union Centre. * Deceased. 790 MEW YORK STATE MEDICAL ASSOCIATION. Founder. Founder. Original. Founder. Original. Original. Founder. Original. Original. Original. Original. Original. Original. Original. Original. Original. Meacham, Isaac D. Binghamton. Moore, William A. Binghamton. Orton, John G. Binghamton. Pierce, Edward A. Binghamton. Pierson, G. E. Kirkwood. Place, John F., Jr. Binghamton. Putnam, Frederick W. Binghamton. Race, W. F. Kearney, Neb. Richards, Charles B. Binghamton. Rogers, Harris C. Binghamton. Seymour, Ralph A. Whitney's Point. Slater, Frank Ellsworth. Binghamton, Wagner, Charles Gray. Binghamton. Wells, E. H. Binghamton. 27 CAYUGA COUNTY. Allison, Henry E. Auburn. Kenyon, M. Moravia. Laird, William R. Auburn. Sawyer, Conant. Auburn. Tripp, John D. Auburn. 5 CHEMUNG COUNTY. Brown, Charles W. Washington, D. C. Drake, E. G. Elmira. Ross, Frank W. Elmira. Squire, Charles L. Elmira. Wales, Theron A. Elmira. 5 CHENANGO COUNTY. Blair, Louis P. McDonough. Brooks, Leroy J. Norwich. Copley, Herman D. Bainbridge. Douglas, George. Oxford. Guy, John D. Coventry. Hand, S. M. Norwich. Hayes, Philetus A. Afton. Johnson, Leonard M. Greene. Lyman, Elijah S. Sherburne. Lyman, H. C. Sherburne. Packer, Thurston G. Smyrna. Smith, Samuel L. Smithville. IIST OF FELLOWS. 791 Original. Founder, Founder. Founder. Original. Original. Original. Original. Original. Founder. Founder. Founder. Thompson, R. A. Norwich. Van Wagner, L. A. Sherburne. Williams, George O. Greene. 15 CORTLAND COUNTY. Bradford, George D. Homer. Clark, DeWitt. Marathon. Didama, E. A. Cortland. *Green, Caleb. Homer. Halbert, M. L. Cincinnatus. Hendrick, Henry C. McGrawville. Higgins, F. W. Cortland. Jewett, Homer O. Cortland. Kenyon, Benjamin. Cincinnatus. 9 DELAWARE COUNTY. *Allaben, Orson M. Margaretville. Drake, James B. Hancock. Morrow, William B. Walton. Smith, George C. Delhi. Travis, Edward M. Masonville. 5 MADISON COUNTY. Birdsall, Gilbert. N. Brookfield. Burhyte, O. W. Brookfield. Cavana, Martin. Oneida. Carpenter, Henry W. Oneida. Drake, Frank C. Oneida. |Huntley, James F. Oneida. Nicholson, A. R. Madison. 7 ONONDAGA COUNTY. Aberdein, Robert. Syracuse. Allen, Henry B. Baldwinsville. Brown, Ulysses H. Syracuse. Campbell, A. J. Syracuse. Dallas, Alexander J. Syracuse. Didama, Henry D. Syracuse. * Deceased. 792 WEW YORK STATE MEDIOAL ASSOCIATION. Original. Original. Original. Founder. Original. Founder. Original. Founder. Original. Original. Founder. Original. Founder. Original. Original. Founder. Original. Original. Original. Donohue, Florence O. Syracuse. Earle, George W. Tully. Edwards, Amos S. Syracuse. Edwards, George A. Syracuse. Elsner, Henry L. Syracuse. Flanigan, John R. Syracuse. Frazee, A. Blair. Elbridge (Altoona, Pa.) Hatch, C. A. Syracuse. - Head, Aldelbert D. Syracuse. Jacobson, Nathan. Syracuse. Rneeland, Jonathan. South Onondaga, Magee, Charles M. Syracuse. McNamara, Daniel. Syracuse. Munson, W. W. Otisco. Parsons, Israel. Marcellus. Saxer, Leonard A. Syracuse. Sears, F. W. Syracuse. Stephenson, F. Halleck, Syracuse. Van de Warker, Ely. Syracuse. Whitford, James. Onondaga Valley. 26 OTSEGO COUNTY. Barney, C. S. Milford. Church, B. A. Oneonta. Ford, M. L. Oneonta. Leaning, John K. Cooperstown. Martin, John H. Otego. Merritt, George. Cherry Walley. Sweet, Joseph J. Unadilla. Sweet, Joshua J. Unadilla. 8 SCEIUYLER COUNTY. Ring, James K. Watkins. Roper, P. B. Alpine. Leffingwell, E. D. Watkins. Smelzer, Baxter T. Havana. Stewart, F. E. Watkins. Woodruff, E. Gerald. Watkins. 6 SENECA COUNTY. Bellows, George A. Waterloo. Blaine, Myron D. Willard. LIST OF FELLOWS. 793 Founder. Original. Original. Founder. Founder. Lester, Elias. Seneca Falls. Pilgrim, Charles W. Willard. Seaman, Frank G. Seneca Falls. Welles, S. R. Waterloo. 6 TIOGA COUNTY Ayer, W. L. Owego. Cady, George M. Nichols. 2 TOMPRINS COUNTY. Beers, John E. Danby. Biggs, Chauncey P. Ithaca. Fitch, William. Dryden. Flickinger, John. Trumansburg. 4 Original. Original. Original. Founder. Founder FOURTH OR WESTERN DISTRICT. ALLEGEIANY COUNTY. Stephenson, James A. Scio. Wakely, Benjamin C. Angelica. 2 CATTARAUGUS COUNTY. Eddy, John L. Olean. Lllsworth, Victor A. Wellsville. Lake, Albert D. Gowanda. Mudge, Selden J. Olean. Tompkins, Orren A. East Randolph. 5 CHAUTAUQUA COUNTY. Ames, Edward. Kalamazoo, Mich. Bemus, Morris N. Jamestown. Bemus, William Marvin. Jamestown *Chace, William. Mayville. * Deceased 794 JNETW YORK STATE MEDICAL ASSOCIATION Founder. Founder. Dean, Harmon J. Brocton. Richmond, Nelson G. Fredonia. Rolph, R. T. Fredonia. Strong, Thomas D. Westfield. - 8 Founder. Original. Original. Original. Original. Original. Original. Original. Founder. Original. Original. Original. Original. Founder. Original. Original. Founder. ERIE COUNTY. Andrews, Judson B. Buffalo. Atwood, H. L. Collins Centre. Banta, Rollin L. Buffalo. Bartlett, Frederick W. Buffalo. Bartow, Bernard. Buffalo. Bergtold, W. H. Buffalo. Boies, Loren F. East Hamburgh. Briggs, Albert H. Buffalo. Brown, George L. Buffalo. Bryant, Percy. Buffalo. Burghardt, Francis Augustus. *Burwell, George N. Buffalo. Cohen, Bernard. Buffalo. Congdon, Charles E. Buffalo. Cronyn, John. Buffalo. Dagenais, Alphonse. Buffalo. Daniels, Clayton M. Buffalo. Dayton, C. L. Buffalo. Dorland, Elias T. Buffalo. Fell, George E. Buffalo. Fowler, Joseph. Buffalo. Frederick, Carlton C. Buffalo. Buffalo. Gould, Cassius W. Buffalo. Green, Stephen S. Buffalo. Greene, DeWitt C. Buffalo. Greene, Joseph C. Buffalo. Greene, Walter D. Buffalo. Harrington, D. W. Buffalo. Hartwig, Marcell. Buffalo. Hayd, Herman E. Buffalo. Heath, William H. Buffalo. Himmelsbach, George A. Buffalo. Howard, Charles F. Buffalo. Hoyer, F. F. Tonawanda. Hubbell, Alvin A. Buffalo. Hunt, H. L. Orchard Park. Ingraham, Henry D. Buffalo. Jackson, William H. Springville. * Deceased, IIST OF FELLO WS. 795 Original. Original. Original. Original. Founder, Founder. Original. Founder. Founder. Original. Original. Original. Johnson, Thomas M. Buffalo. Jones, Allen A. Buffalo. Lapp, Henry. Clarence. Long, Ben. G. Buffalo. Macfarlane, William A. Springville. McPherson, George W. Lancaster. Murray, William D. Tonawanda. Park, Roswell. Buffalo. Pettit, John A. Buffalo. Phelps, William C. Buffalo. Pohlman, Julius. Buffalo. Putnam, James W. Buffalo. Rochester, DeLancey. Buffalo. Stockton, Charles G. Buffalo. Strong, Orville C. Colden. Taber, R. C. Tonawanda. Thornton, William H. Buffalo. Tremaine, William S. Buffalo. Trull, H. P. Williamsville. Twohey, John J. Buffalo. Wall, Charles A. Buffalo. Wheeler, Isaac G. Marilla. Whipple, Electa B. Buffalo. Willoughby, M. Buffalo. Wyckoff, Cornelius C. Buffalo. 63 GENESEE COUNTY. Andrews, Lewis B. Byron. Crane, Frank W. Corfu. Jackson, Albert P. Oakfield. Prince, Alpheus. Byron. Stone, Frank L. Le Roy. Townsend, Morris W. Bergen. 6 LIVINGSTON COUNTY. Briggs, Wm. H. Hemlock Lake. Brown, J. P. Tuscarora. Dodge, Frank H. Mount Morris. Jones, George H. Fowlerville. Eneeland, B. T. Dalton. Menzie, R. J. Caledonia. Moyer, Frank H. Moscow. 7 796 NEW YORK STATE MEDICAL ASSOOIATION. Original. Original. Original. Original. Original. Founder. Founder. Original. Original. Original. Original. Original. Original. Original. Founder. Original. Founder. Founder. Original. MONROE COUNTY. Backus, Ogden. Rochester. Briggs, C. M. Fairport. Buckley, Charles. Rochester. Buckley, James. Rochester. Burke, John J. A. Rochester. Curtis, D. F. Rochester. Dunning, J. D. Webster. Fenno, Henry M. Rochester. Goler, George W. Rochester. Gray, John P. Rochester. Hovey, B. L. Rochester. Jones, S. Case. Rochester. Maine, Alva P. Webster. McDougall, William D. Spencerport. Moore, Edward M. Rochester. Moore, Edward M., Jr. Rochester. Moore, Richard Mott. Rochester. Nold, John B. Rochester. O'Hara, Thomas A. Tºochester. Pease, Joseph. Hamlin. Reitz, Charles. Webster. Schopp, Justin H. Rochester. Snook, George M. Parma. Stockschlaeder, P. Rochester. 24. NIAGARA COUNTY. *Clark, Simeon T. Lockport. Eddy, George P. Lewiston. Huggins, William Q. Sanborn. 3 ONTARIO COUNTY. Allen, Duncan S. Seneca. Allen, James H. Gorham. Bentley, Francis R. Cheshire. De Laney, John Pope. Geneva. Hicks, W. Scott, Bristol. Nichols, H. W. Canandaigua. Simmons, E. W. Canandaigua. Wanderhoof, Frederick D. Phelps. 8 * Deceased. LIST OF FELLOWS. 797 Original. Founder. Original. Founder. Original. Original. Original. Original. Founder, Founder. Original. Original. Original. Original. Original. Original. Original. ORLEANS COUNTY. Bailey, William C. Albion. Chapman, James. Medina. Curtis, Daniel. Jeddo. Taylor, John H. Holley. Tompkins, H. C. Knowlesville. 5 STEUBEN COUNTY. Chittenden, Daniel J. Addison. Dunn, Jeremiah. Bath. Ellison, Metler D. Canisteo. Fowler, Thomas B. Cohocton. Gilbert, Horatio. Hornellsville, Hubbard, Chauncey G. Hornellsville. Hunter, Nathaniel P. Jasper. Jamison, John S. Hornellsville. Perry, Nathaniel M. Troupsburgh. Wallace, Edwin E. Jasper. 10 WAYNE COUNTY. Arnold, J. Newton. Clyde. Brandt, J. S. Ontario Centre. Colvin, Darwin. Clyde. Horton, David B. Red Creek. Ingraham, Samuel. Palmyra. Landon, Newell E. Newark. Nutten, Wilbur F. Newark. Sprague, John A. Williamson. Sprague, L. S. Williamson. Young, Augustus A. Newark. 10 WYOMING COUNTY. Ellinwood, A. G. Attica. Fisher, John C. Warsaw. Hulette, G. S. Arcade. Lusk, Zera J. Warsaw. Palmer, George M. Warsaw. Rae, Robert. Portageville. Rudgers, Denton W. Perry. 7 YATES COUNTY. Oliver, William. Penn Yau. 1 798 INEW YORK STATE MEDICAL ASSOCIATION. Original. Original. Original. Founder. Founder. Original. Founder. Founder. Founder. Founder. Original. Original. FIFTH OR SOUTHERN DISTRICT. DUTCHESS COUNTY. Baker, Benjamin N. Rhinebeck. Barnes, Edwin. Pleasant Plains. Barton, Thomas J. Tivoli. Bates, Xyris T. Poughkeepsie. Bayley, Guy Carleton. Poughkeepsie. Bird, J. S. Hyde Park. Codding, George H. Amenia. Cramer, William. Poughkeepsie. Fletcher, Charles L. Wing's Station. Hicks, Edward E. Poughkeepsie. Julian, John M. Moore's Mill. Rittredge, Charles S. Fishkill-on-Hudson. Leroy, Irving D. Pleasant Valley. Porteous, James G. Poughkeepsie. Pultz, Monroe T. Stanfordville. Van Wyck, Richard C. Hopewell Junction. Young, John. Fishkill-on-Hudson. 17. Founder. Original. Original. Original. Original. Original. Original. KINGS COUNTY. Alleman, L. A. W. Brooklyn. Baker, Frank R. Brooklyn. Baker, George W. Brooklyn, E. D. Beardsley, William E. Brooklyn. Bell, A. Nelson. Brooklyn. Benton, Stuart H. Brooklyn. Bierwirth, Julius C. Brooklyn. Biggam, William H., Jr. Brooklyn. Brundage, Amos H. Brooklyn. Conway, John Francis. Brooklyn. Coffin, Laurence. Brooklyn. *Creamer, Joseph. Brooklyn, E. D. Creamer, Joseph, Jr. Brooklyn, E. D. Criado, Louis F. Brooklyn. Feeley, James F. Brooklyn, E. D. Gardiner, William F. Brooklyn. Hughes, Peter. Brooklyn. Hull, Thomas H. Brooklyn. Ilgen, Ernst. Brooklyn. Jenkins, John A. Brooklyn, E. D. Jewett, F. A. Brooklyn. Leighton, Nathaniel W. Brooklyn. Little, Frank. Brooklyn. *Deceased. LIST OF FELLOWS. 799 Original. Original. Original. Original. Original. Original. Original. Founder. Original. Founder. Original. Original. Founder. Founder. Original. Original. Original. Founder. Original. Original. Original. Original. Founder. Lloyd, T. Mortimer. Brooklyn. Lung, Jesse B. Brooklyn. McCollom, William. Brooklyn. Minard, E. J. Chapin. Brooklyn. Newman, George W. Brooklyn. North, Nelson L. Brooklyn. Ostrander, George A. Brooklyn. Paine, Arthur R. Brooklyn. Pray, S. R. Brooklyn. Price, Henry R. Brooklyn. Raynor, F. C. Brooklyn. Reed, Henry B. Brooklyn. Richardson, John E. Brooklyn. Risch, Henry F. W. Brooklyn. Rochester, Thomas M. Brooklyn. Rushmore, John D. Brooklyn. Russell, William G. Brooklyn. Segur, Avery. Brooklyn. Shepard, A. Warren. Brooklyn. Sizer, Nelson Buell. Brooklyn. Squibb, Edward H. Brooklyn. Squibb, Edward R. Brooklyn. Steinke, Carl Otho Hermann. Brooklyn. Sullivan, John D. Brooklyn. Thwing, Clarence. Brooklyn. Waterworth, William. Brooklyn. Wieber, George. Brooklyn. Williams, William H. Brooklyn. Wyckoff, Richard M. Brooklyn, 52 NEW YORK COUNTY. Adams, Calvin Thayer. New York. Agramonte, E. W., New York. Allen, S. Busby. New York. Allen, Thomas H. New York. Andrews, John L. New York. Arango, Augustin. New York. Arcularius, Lewis. New York. Armstrong, S. T. New York. Arnold, Edmund S. F. New York. Arnold, Glover C. New York. Baldwin, F. A. New York. Ballou, William R. New York. Bermingham, Edward J. New York. Biggs, Herman M. New York. Bozeman, Nathan. New York. 800 IVEVW YORK STATE MEDICAL ASSOCIATION. Original. Original. Original. Rozeman, Nathan G. New York. Broderick, William P. New York. Bryant, Joseph D. New York. Buchanan, Alexander. New York. |Bull, Charles Stedman. New York. Bull, William T. New York. Burchard, Thomas H. New York. Original. Founder. Original. Original. Original. Founder. Original. Original. Original. Founder. Original. Original. Original. Founder. Founder. Original. Campbell, Clarence G. New York. Carroll, Alfred Ludlow. New York. Carter, H. Skelton. New York. Chauveau, Jean F. New York. Chrystie, T. M. Ludlow. New York. Collins, Stacy B. New York. Comfort, John E. New York. Conover, William S. New York. Conway, John R. New York. Curry, Walker. New York. Dallas, Alexander. New York. *Damainville, Lucien. Kings Bridge. Daniels, F. H. New York. Davis, J. Griffith. New York. Davis, Robert C. New York. De Garmo, W. B. New York. Delphey, Eden W. New York. Denison, C. Ellery. New York. Denison, Ellery. New York. Dennis, Frederic S. New York. de Quesada, Gregorio J. New York. Du Bois, Matthew B. New York. Dudley, A. Palmer. New York. Dunham, Edward K. New York. Pastman, Robert W. New York. Einhorn, Max. New York. Eliot, Ellsworth. New York. Prdmann, John F. New York. Farrington, Joseph O. New York. Eield, Matthew D. New York. Flinn, Thomas W. P. New York. Flint, Austin. New York. Flint, Austin, Jr. New York. Flint, William H. New York. Fogg, John S. New York. Foster, George W. New York. Frankenberg, Jacob H. New York. Furman, Guido. New York. Gleitsmann, J. W. New York. Goldthwaite, Henry. New York. * Deceased. LIST OF FELLOWS. 801 Founder. Original. Founder. Founder. Founder. Founder. Founder. Founder. Founder. Original. Original. Founder. Gouley, John W. S. New York. Grauer, Frank. New York. Gray, Joseph F. New York. Gulick, A. Reading. New York. Gulick, Charlton R. New York. Hammond, Frederick Porter. New York. Harrison, George Tucker. New York. Haubold, H. A. New York. Hepburn, Neil J. New York. Hillis, Thomas J. New York. Hinton, John H. New York. Hodgman, Abbott. New York. Hogan, M. K. New York. Holmes, Martha C. New York. Hubbard, Dwight L. New York. Hubbard, George E. New York. Hubbard, Samuel T. New York. Jackson, Charles W. New York. Janeway, Edward G. New York. Janvrin, J. E. New York. Jenkins, William T. New York. Judson, A. B. New York. Remp, William M. New York. King, Ferdinand. New York. Kneer, F. G. New York. Knipe, George. New York. Leale, Charles A. New York. Lewis, Robert. New York. Little, Albert H. New York. Lockwood, Charles E. New York. Ludlow, Ogden C. New York. Lukens, Anna. New York. Lusk, William T. New York. Lynch, Patrick J. New York. MacGregor, James R. New York. Mackenzie, J. C. New York. McBurney, Charles. New York. McGillicuddy, T. J. New York. McGowan, John P. New York. McIlroy, Samuel H. New York. McLeod, Johnston. New York. McLeod, S. B. Wylie. New York. McLochlin, James A. New York. McNamara, Laurence J. New York. Manley, Thomas H. New York. Marshall, Francis F. New York. *Matthews, David. New York. * Deceased. 802 MEW YORK STATE MEDICAL ASSOCIATION. Original. Original. Original. Original. Original. Original. Founder. Original. Original. Original. Original. Founder. Original. Original. Founder. Original. *Maury, Rutson. New York. Meier, Gottlieb C. H. New York. Miller, William T. New York. Milliken, S. E. New York. Miranda, Ramon L. New York. Mitchell, Hubbard W. New York. Moran, James. New York. Mott, Walentine. New York. Murphy, John. New York. Murray, Sandford J. New York. Newman, Robert. New York. Nicoll, Henry D. New York. Obendorfer, Isidor P. New York. O’Brien, Frederick William. New York. O'Brien, M. Christopher. New York. Ochs, Benjamin F. New York. Oppenheimer, H. S. New York. Oppenheimer, S. New York. Palmer, Edmund J. New York. Parsons, John. New York. Perry, John Gardner. New York. Phelps, Charles. New York. Pooler, Hiram A. New York. Porter, P. Brynberg. New York. Pritchard, R. L. New York. Purple, Samuel S. New York. Ransom, H. B. New York. Rau, Leonard S. New York. Read, Ira B. New York. Ricketts, Benjamin M. Cincinnati, Ohio. Roth, Julius A. New York. Ruggles, Augustus D. New York. Sabine, Gustavus A. New York. Sanders, E. New York. Sayre, Lewis A. New York. Sayre, Reginald H. New York. Seaman, Louis L. New York. Shaw, Henry B. New York. Shea, Dennis L. New York. Shrady, John. New York. Shrady, John Eliot. New York. Shunk, Albert. New York. Silver, Henry M. New York. Simmons, Charles E. New York. Smeallie, James A. New York. Smith, J. Lewis. New York. * Deceased. LIST OF FELLOWS. 803 Original. Original. Founder. Founder. Original. Founder. Founder. Founder. Founder. Original. Original. Founder. Founder, Smith, Samuel W. New York. Smith, Stephen. New York. Spicer, Walter E. New York. Thomas, T. Gaillard. New York. Thompson, Won Beverhout. New York. Tiemann, Paul E. New York. Truax, J. G. New York, * Tucker, Carlos P. New York. Van Fleet, Frank. New York. Vincent, Ludger C. New York. Won Dönhoff, Edward. New York. Wallach, Joseph G. New York. Walsh, Simon J. New York. Ward, Charles S. New York. Warner, Frederic M. New York. Warner, John W. New York. Weeks, John E. New York. Weston, Albert T. New York. White, Charles B. New York. White, J. Blake. New York. White, Whitman W. New York. White, William T. New York. Wiener, Joseph. New York. Wiggin, Frederick Holme. New York. Williams, Henry Smith. New York, Williamson, Edward A. New York, Woodend, William E. New York. Wyeth, John A. New York. 183 ORANGE COUNTY. Conner, Milton C, Middletown. Davis, J. O. Howells, *Hunt, James H. Port Jervis. Potts, E. Port Jervis. Swartwout, H. B. Port Jervis. Townsend, Charles E. Middletown, Vanderweer, J. C. Monroe. Wanderweer, J. R. Monroe. 8 PUTNAMI COUNTY. Murdock, George W. Cold Spring. Young, William. Cold Spring. 2 * Deceased. 51 804. NEW YORK STATE MEDICAL ASSOCIATION. QUEENS COUNTY. Original. Burns, William J. Roslyn. Original. Rave, Edward G. Oyster Bay. - 2 RICHMOND COUNTY. Founder. *Johnston, Francis U. New Brighton. Johnston, Henry C. New Brighton. Martindale, F. E. Port Richmond. Walser, William C. Port Richmond. 4 ROCKLAND COUNTY. Founder. Govan, William. Stony Point. 1 SUFFOLE COUNTY. Original. Chambers, Martin L. Port Jefferson. Hamill, Edward H. Newark, N. J. Hulse, William A. Bay Shore. Original. Lindsay, Walter. Huntington. Founder. *Woodend, William D. Huntington. 5 SULLIVAN COUNTY. Original. Bennett, Thomas W. Jeffersonville. Crocker, Edwin. Narrowsburgh, DeKay, William H. Parksville. Johnston, N. B. Barryville. McWilliams, F. A. Monticello. Original. Munson, J. A. Grahamsville. Piper, Charles W. Wurtsborough. 7 ULSTER COUNTY. Original. Chambers, Jacob. Kingston. Original. Hoorn Beek, Philip Du Bois. Wawarsing. Founder. Hühne, August. Rondout. Original, Hühne, Frederick. Rondout. Original. Van Hovenberg, Henry. Kingston. Ward, John J. Ellenville. 6 * Deceased, LIST OF FELLOWS. 805 WESTCHESTER COUNTY. Acker, Thomas J. Croton-on-Hudson. Original. Banks, George B. Hartsdale. Original. Brush, Edward F. Mount Vernon. Original. Coutant, Richard B. Tarrytown. Dunham, Theodore. Irvington. --- Original. Furman, J. Henry. Tarrytown. Granger, William D. Mount Vernon. Original. Huntington, Henry K. New Rochelle. Founder. *Husted, Nathaniel C. Tarrytown. Original. Lyons, G. A. New Rochelle. Original. Schmid, H. Ernest. White Plains. Small, John W. New Rochelle. Original. Southworth, Richmond Joseph. Yonkers. Original. Wells, William L. New Rochelle. 14 *Deceased. SUMMARY OF FELLOWSHIP BY DISTRICT, First District, & * * * e tº * * ſº & 84 Second District, . g * * g & tº e * . 129 Third District, e gº e . gº * & e e . 125 Fourth District, . e g * e wº e e g . 159 Fifth District, te g e e º e g e & . 301 Non-resident, * gº & & & * & * © o 2 Total Fellowship, * & {º g © * * . S00 ALPHABETICAL LIST OF FELLOWs. Abell, Ira H., Antwerp, Jefferson Co. Founder. Aberdein, Robert, Warren and Fayette Sts., Syracuse, Onondaga Co. Original. - Abrams, H. C., Newtonville, Albany Co. Acker, Thomas, J., Croton-on-Hudson, Westchester Co. Adams, Calvin Thayer, 8 W. 33d St., New York, New York Co. Agramonte, E. W., 267 W. 45th St., New York, New York Co. *Allaben, Orson M., Margaretville, Delaware Co. Original. Alleman, L. A. W., 64 Montague St., Brooklyn, Kings Co. Allen, Amos, Grafton, Rensselaer Co. Original. Allen, Charles S., Greenbush, Rensselaer Co. Founder. Allen, Duncan S., Seneca, Ontario Co. Original. Allen, Henry B., Baldwinsville, Onondaga Co. Founder. Allen, Henry J., Corinth, Saratoga Co. Allen, James H., Gorham. Ontario Co. Original. Allen, S. Busby, 164 E. 89th St., New York, New York Co. Allen, S. P., Whitney’s Point, Broome Co. Allen, Thomas H., 52 W. 45th St., New York, New York Co. Allen, William L., Greenbush, Rensselaer Co. Allison, Henry E., Asylum for Insane Criminals, Auburn, Cayuga Co. Ames, Edward, 123 E. Lovell St., Kalamazoo, Mich. Founder. Andrews, John L., 323 E, 86 St., New York, New York Co. Andrews, Judson B., State Hospital, Buffalo, Erie Co. Founder. Andrews, Lewis B., Byron, Genesee Co. Arango, Augustin, 125 E. 36th St., New York, New York Co. Arcularius, Lewis, 121 E. 25th St., New York, New York Co. Original. Armstrong, James A., Clinton, Oneida Co. Armstrong, S. T., 166 W. 54th St., New York, New York Co. Arnold, Edmund S. F., 64 Madison Ave., New York, New York Co. Original. Arnold, Glover C., 115 E. 30th St., New York, New York Co. Arnold, J. Newton, Clyde, Wayne Co. Founder. Atwood, H. L., Collins Centre, Erie Co. Original. Ayer, W. L., Owego, Tioga Co. Original. Ayres, Douglas, Fort Plain, Montgomery Co. Original. Babcock, H. E., New London, Oneida Co. Original. * Deceased, ALPEIABETICAL LIST OF FELLOWS. 807 * Babcock, Myron N., Saratoga Springs, Saratoga Co. Founder. Backus, Ogden, 67 S. Fitzhugh St., Rochester, Monroe Co. Original. Bacon, Charles G., Fulton, Oswego Co. (Retired list.) Bagg, Moses M., Utica, Oneida Co. Original. (Retired list.) Bailey, Theodore P., 95 Eagle St., Albany, Albany Co. Founder. Bailey, William C., Albion, Orleans Co. Original. Baker, Benjamin N., Rhinebeck, Dutchess Co. Baker, Frank R., 540 Bedford Ave., Brooklyn, E. D., Kings Co. Baker, George W., 540 Bedford Avenue, Brooklyn, E. D., Kings Co. Founder. * Baldwin, F. A., 329 W. 23d St., New York, New York Co. Ballou, William R., Oakland Heights Sanitarium, Asheville, N. C. Banks, George B., Hartsdale, Westchester Co. Original. (Retired list.) Banta, Rollin L., 330 Elk St., Buffalo, Erie Co. Original. Barnes, Edwin, Pleasant Plains, Dutchess Co. Original. Barney, Charles S., Milford, Otsego Co. Original. Barnum, D. Albert, Cassville, Oneida Co. Bartlett, Frederick W., 523 Delaware Ave., Buffalo Erie Co. Original. Barton, Lyman, Willsborough, Essex Co. Founder. (Retired list.) Barton, Thomas J., Red Hook, Dutchess Co. Bartow, Bernard, 220 Franklin St., Buffalo, Erie Co. Bates, Nelson W., Central Square, Oswego Co. Bates, Xyris T., Poughkeepsie, Dutchess Co. Original. Bayley, Guy Carleton, Poughkeepsie, Dutchess Co. Original. Baynes, Joseph E., 2419 5th Ave., Troy, Rensselaer Co. *Baynes, William T., 2419 5th Ave., Troy, Rensselaer Co. Original. Beardsley, William E., 101 Taylor St., Brooklyn, Kings Co. Beers, John E., Danby, Tompkins Co. Founder. Bell, A. Nelson, 291 Union St., Brooklyn, Kings Co. Bellows, George A., Waterloo, Seneca Co. Bemus, Morris N., Jamestown, Chautauqua Co. Bemus, Wm. Marvin, Jamestown, Chautauqua Co. Benham, John C., Hudson, Columbia Co. Original. Bennett, Thomas W., Jeffersonville, Sullivan Co. Original. Bentley, Francis R., Cheshire, Ontario Co. Original. (Retired list.) Benton, Stuart H., 1063 Bergen St., Brooklyn, Kings Co. Bergtold, W. H., 56 Allen St., Buffalo, Erie Co. Bermingham, Edward J., 7 W. 45th St., New York, New York Co. Bierwirth, Julius C., 187 Montague St., Brooklyn, Kings Co. Biggam, William H., Jr., 1095 Dean St., Brooklyn, Kings Co. Original. Biggs, Chauncey P., 14 E. Seneca St., Ithaca, Tompkins Co. Biggs, Hermann M., 58 E. 25th St., New York, New York Co. Original. Bird, J. S., Hyde Park, Dutchess Co. Birdsall, Gilbert, North Brookfield, Madison Co. Original. Bissell, James H., 2187 5th Ave., Troy, Rensselaer Co. * Deceased. 808 NEW YORK STATE MEDICAL ASSOCIATION: Blaine, Myron D., Willard, Seneca Co. Blair, Louis P., McDonough, Chenango Co. Original. Blake, Clarence R., Northville, Fulton Co. Original. Blumer, G. Alder, State Hospital, Utica, Oneida Co. Original. Boies, Loren F., 286 Howard Ave., Buffalo, Erie Co. Original. Bond, G. F. M., State Hospital, Utica, Oneida Co. Bonesteel, H. F., Mill St., Troy, Rensselaer Co. Bonesteel, William N., Mill St., Troy, Rensselaer Co. Founder. (Re- tired list.) Bontecou, Reed B., 82 4th St., Troy, Rensselaer Co. Original. Booth, Wilbur H., 172 Genesee St., Utica, Oneida Co. Original. Boyce, Elias B., Averill Park, Rensselaer Co. Dozeman, Nathan, 9 W. 31st St., New York, New York Co. Founder. Bozeman, Nathan G., 9 W. 31st St., New York, New York Co. Bradford, George D., Homer, Cortland Co. Bradley, O. Howard, Hudson, Columbia Co. Brandt, J. S., Ontario Center, Wayne Co. Briggs, Albert H., 267 Hudson St., Buffalo, Erie Co. Original. Briggs, C. M., Fairport, Monroe Co. Briggs, William H., Hemlock Lake, Livingston Co. Original. Broderick, William P., 272 Willis Ave., New York, New York Co. Brooks, Leroy J., Norwich, Chenango Co. Original. Brown, Charles W., 902 14th St., N. W., Washington, D. C. Original. Brown, George L., 121 Franklin St., Buffalo, Erie Co. Brown, J. P., Nunda, Livingston Co. Brown, Ulysses H., 312 Warren St., Syracuse, Onondaga Co. Brundage, Amos H., 609 Madison St., Brooklyn, Kings Co. Original. Brush, Edward F., Mount Vernon, Westchester Co. Original. Brush, Edward N., Shepperd Asylum, Towsen, Md. Original. Bryant, Joseph D., 54 W. 36th St., New York, New York Co. Original. Bryant, Percy, State Hospital, Buffalo, Erie Co. Buchanan, Alexander, 358 W. 30th St., New York, New York Co. Original. Buckley, Charles, 127 E. Main St., Rochester, Monroe Co, Original. Buckley, James, 127 E. Main St., Rochester, Monroe Co. Original. Bull, Charles Stedman, 47 W. 36th St., New York, New York Co. Original. Bull, William T., 35 W. 35th St., New York, New York Co. Burbeck, Charles H., 91 First St., Troy, Rensselaer Co. Founder. Burchard, Thomas H., 7 E. 48th St., New York, New York Co. Original. Burghardt, Francis Augustus, 632 Elm St., Buffalo, Erie Co. Burhyte, O. W., Brookfield, Madison Co. Burke, John J. A., 65 East Ave., Rochester, Monroe Co. Original. Burns, Wm. J., Roslyn, Queens Co. Original. Burton, Matthew H., 754th St., Troy, Rensselaer Co. Founder. *Burwell, George N., 130 Pearl St., Buffalo, Erie Co. Original. *Deceased. ALPHABETICAL LIST OF FELLO WS. 809 Cady, George M., Nichols, Tioga Co. Cahill, John T., Hoosick Falls, Rensselaer Co. Caldwell, Nathan A., Hageman’s Mills, Montgomery Co. Campbell, A. J., 332 Warren St., Syracuse, Onondaga Co. Campbell, Clarence G., 36 W. 33d St., New York, New York Co. Carpenter, Henry W., Oneida, Madison Co. Original. Carroll, Alfred Ludlow, 30 W. 59th St., New York, New York Co. . Carter, H. Skelton, 130 E. 24th St., New York, New York Co. Original. Casey, J. E., Mohawk, Herkimer Co. Cavana, Martin, Oneida, Madison Co. - *Chace, William, Mayville, Chautauqua Co. Founder. Chambers, Jacob, Kingston, Ulster Co. Original. - Chambers, Martin L., Port Jefferson, Suffolk Co. Original. Chapman, James, Medina, Orleans Co. Founder. Chauveau, Jean F., 31 W. 60th St., New York, New York Co. Original. Chittenden, Daniel J., Addison, Steuben Co. Chittenden, Joseph H., Binghamton, Broome Co. Founder. Chrystie, T. M. Ludlow, 216 W. 46th St., New York, New York Co. Original. Church, B. A., Oneonta, Otsego Co. Church, Charles A., Bloomingdale, Essex Co. Churchill, Alonzo, 189 Genesee St., Utica, Oneida Co. (Retired list.) Clark, Dewitt C., Marathon, Cortland Co. Original. *Clark, Simeon Tucker, Lockport, Niagara Co. Original. Clarke, Wallace, 136 Park Ave., Utica, Oneida Co. Clum, Franklin D., Cheviot, Columbia Co. Codding, George H., Amenia, Dutchess Co. Founder. Coffin, Lawrence, 473 Bedford Ave., Brooklyn, Kings Co. Cohen, Bernard, 540 Niagara St., Buffalo, Erie Co. Collins, Stacy B., 106 E. 35th St., New York, New York Co. Colvin, Darwin, Clyde, Wayne Co. Founder. Comfort, John E., 1315 Franklin Ave., New York, New York Co. Comstock, George F., Saratoga Springs, Saratoga Co. Founder. Congdon, Charles E., 1034 Jefferson St., Buffalo, Erie Co. Conkling, George, Durham, Greene Co. Original. Conner, Milton C., Middletown, Orange Co. Conover, William S., 237 W. 132d St., New York, New York Co. Founder. Conway, John Francis, cor. Buffalo and Union Sts., Brooklyn, Kings Co. Original. Conway, John R., 130 Lexington Ave., New York, New York Co. Cook, Guy Reuben, Louisville, St. Lawrence Co. Cooley, F. L., 210 First St., Oswego, Oswego Co. Cooley, R. N., Hannibal Centre, Oswego Co. Cooper, William C., 81 3d St., Troy, Rensselaer Co. Original. Copley, Herman D., Bainbridge, Chenango Co. *Deceased. 810 NEW YORK STATE MEDICAL ASSOCIATION. Coutant, Richard B., Tarrytown, Westchester Co. Original. Cramer, William, 136 Mansion St., Poughkeepsie, Dutchess Co. Founder. Crane, Frank W., Corfu, Genessee Co. Original. Crawe, J. Mortimer, Watertown, Jefferson Co. Founder. *Creamer, Joseph, 154 Hewes St., Brooklyn, E. D., Kings Co. Creamer, Joseph, Jr., 168 N. 6th St., Brooklyn, E. D., Kings Co. Criado, Louis F., 147 Fort Green Place, Brooklyn, Kings Co. Crocker, Edwin, Narrowsburgh, Sullivan Co. Crombie, Walter C., Mechanicsville, Saratoga Co. Original. Cronyn, John, 55 W. Swan St., Buffalo, Erie Co. Founder. Crosby, Alexander H., Lowville, Lewis Co. Crounse, Andrew C., Melrose, Rensselaer Co. Curry, Walker, 21 E. 61st St., New York, New York Co. Original. Curtis, Daniel, Jeddo, Orleans Co. Curtis, D. F., 95 South Ave., Rochester, Monroe Co. Curtis, P. C., Round Lake, Saratoga Co. - Dagenais, Alphonse, 473 W. Virginia St., Buffalo, Erie Co. Original. Dallas, Alexander, 65 W. 36th St., New York, New York Co. Dallas, Alexander J., 48 Warren St., Syracuse, Onondaga Co. Founder. *Damainville, Lucien, 3007 Broadway, New York, New York Co. Daniels, Clayton M., 868 Main St., Buffalo, Erie Co. Original. Daniels, F. H., 126 W. 126th St, New York, New York Co. D'Avignon, Francis J., Au Sable Forks, Essex Co. Original. Davis, J. Griffith, 132 W. 12th St., New York, New York Co. Davis, J. O., Howells, Orange Co. Davis, Robert C., 150 E. 128th St., New York, New York Co. Dayton, C. L., 246 Dearborn St., Buffalo, Erie Co. (Retired list.) Dean, Harmon J., Brocton, Chautauqua Co. Founder. De Garmo, W. B., 56 W. 36th St., New York, New York Co. DeKay, William H., Parksville, Sullivan Co. De Laney, John Pope, Geneva, Ontario Co. Delphey, Eden W., 339 W. 59th St., New York, New York Co. Denison, Charles Ellery, 124 W. 13th St., New York, New York Co. Original. Denison, Ellery, 124 W. 13th St., New York, New York Co. Original. Dennis, Frederic S., 542 Madison Ave., New York, New York Co. Founder. de Quesada, Gregorio J., 307 W. 28th St., New York, New York Co. De Witt, Byron, Oswego, Oswego Co. Original. de Zouche, Isaac, Gloversville, Fulton Co. Founder. Dickson, Thomas Gordon, Troy, Rensselaer Co. Didama, Emory A., Cortland, Cortland Co. Didama, Henry D., 112 S. Salina St., Syracuse, Onondaga Co. Founder. Dodge, Amos P., Oneida Castle, Oneida Co. Dodge, Frank B., Mount Morris, Livingston Co. Dodge, Lyndhurst C., Rouse's Point, Clinton Co. Founder. *Deceased. ALPHABETICAL LIST OF FELLOWS. 811 Donohue, Florence O., 410 Warren St., Syracuse, Onondago Co. Original. Dorland, Elias T., 86 N. Division St., Buffalo, Erie Co. Original. Douglas, George, Oxford, Chenango Co. * Douglass, A. J., Illion, Herkimer Co. Douglass, Charles E., Lowville, Lewis Co. Douglass, James W., Booneville, Oneida Co. Drake, D. Delos, Johnstown, Fulton Co. Drake, E. G., 312 W. Church St., Elmira, N. Y. Drake, Frank C., Oneida, Madison Co. Drake, James B., Hancock, Delaware Co. Du Bois, Matthew B., 156 Broadway, Manhattan Life Ins. Co., New York, New York Co. Original. I)udley, A. Palmer, 640 Madison Ave., New York, New York Co. Dudley, Dwight, Maine, Broome Co. Dunham, Edward K., 347 Lexington Ave., New York, New York Co. Dunham, Theodore, 347 Lexington Ave., New York, New York Co. Dunlop, John J., Waterford, Saratoga Co. Original. Dunn, Jeremiah, Bath, Steuben Co. Original. Dunning, J. D., Webster, Monroe Co. Original. Earle, George W., Tully, Onondago Co. Eastman, Robert W., 170 W. 78th St., New York, New York Co. Original. Eddy, George P., Lewiston, Niagara Co. Eddy, John L., Olean, Cattaraugus Co. Edwards, Amos S., 1506 N. Salina St., Syracuse, Onondaga Co. Original. Edwards, George A., Catherine and Lodi Sts., Syracuse, Onondaga Co. Original. Edwards, John, Gloversville, Fulton Co. Einhorn, Max, 107 E. 65th St., New York, New York Co. Eliot, Ellsworth, 48 W. 36th St., New York, New York Co. Original. Ellinwood, A. G., Attica, Wyoming Co. Original. Ellis, J. B., Whitesborough, Oneida Co. Ellison, Metler D., Canisteo, Steuben Co. Original. Ellsworth, Victor A., Wellsville, Cattaraugus Co. Elsner, Henry L., 308 N. Salina St., Syracuse, Onondaga Co. Founder. Ely, Henry Oliver, Binghamton, Broome Co. Original. English, G. P., Booneville, Oneida Co. Erdmann, John F., 141 W. 34th St., New York, New York Co. Farnham, LeRoy D., Binghamton, Broome Co. Farrington, John M., Binghamton, Broome Co. Farrington, Joseph O., 1991 Madison Ave., New York, New York Co. Feely, James F., 296 Lorimer St., Brooklyn, E. D., Kings Co. Fell, George E., 72 Niagara St., Buffalo, Erie Co. Fenno, Henry Marshall, 77 W. Main St., Rochester, Monroe Co. Ferguson, E. D., 1 Union Place, Troy, Rensselaer Co. Founder. *Ferguson, James, Glens Falls, Warren Co. Original. (Retired list.) Field, Matthew D., 115 E. 40th St., New York, New York Co. * Deceased. 812 NEW YORK STATE MEDICAL ASSOCIATION. Finder, William Jr., 2 Union Place, Troy, Rensselaer Co. Founder. Fisher, John C., Warsaw, Wyoming Co. Fitch, William, Dryden, Tompkins Co. Founder. Fitzgerald, David J., Glens Falls, Warren Co. Fitzgerald, John F., State Hospital, Binghamton, Broome Co. Flandrau, Thomas M., Rome, Oneida Co. Flanigan, John R., Syracuse, Onondaga Co. Fletcher, Charles L., Wing's Station, Dutchess Co. Original. Flickinger, John, Trumansburg, Tompkins Co. Flinn, Thomas W. P., 137 E. 28th St., New York, New York Co. Flint, Austin, 60 E. 34th St., New York, New York Co. Founder. Flint, Austin, Jr., 252 Madison Ave., New York, New York Co. Flint, William H., 37 E. 33d St., New York, New York Co. Founder. Fogg, John S., 602 Tremont St., Boston, Mass. Ford, M. L., Oneonta, Otsego Co. Forker, Frederick L., Binghamton, Broome Co. Foster, George W., 109 E. 18th St., New York, New York Co. Fowler, Joseph, 31 Church St., Buffalo, Erie Co. Fowler, Thomas B., Cohocton, Steuben Co. Frankenberg, Jacob H., 142 E. 74th St., New York, New York Co. Fraser, Jefferson C., Ava, Oneida Co. Frazee, A. Blair, Altoona, Pa. Frederick, Carlton C., 64 Richmond Ave., Buffalo, Erie Co. French, S. H., Amsterdam, Montgomery Co. Fritts, Crawford Ellsworth, Hudson, Columbia Co. Fuller, Earl D., 66 Varick St., Utica, Oneida Co. Fuller, Robert, Schenectady, Schenectady Co. Furman, Guido, 125 W. 73d St., New York, New York Co. Original. Furman, J. Henry, Tarrytown, Westchester Co. Original. Gardiner, W. F., 1756th Ave., Brooklyn, Kings Co. Garlock, William D., Little Falls, Herkimer Co. Getty, A. H., Athens, Greene Co. Gibson, William M., 187 Genesee St., Utica, Oneida Co. Gilbert Horatio, Hornellsville, Steuben Co. Gillis William, Fort Covington, Franklin Co. Founder. Gleitsmann, J. W., 46 E. 25th St., New York, New York Co. Glidden, Charles H., Little Falls, Herkimer Co. Original. Goldthwaite, Henry, Fifth Avenue Hotel, New York, New York Co. Goler, George W., 54 S. Fitzhugh St., Rochester, Monroe Co. Gould, Cassius W., 1428 Main St., Buffalo, Erie Co. Gouley, John W. S., 324 Madison Ave., New York, New York Co. Founder. Govan, William, Stony Point, Rockland Co. Founder. Gow, Frank F., Schuylerville, Saratoga Co. Granger, William D., Bronxville (Vernon House), Westchester Co. Grant, Charles S., Saratoga Springs, Saratoga Co. Founder. Grauer, Frank, 326 W. 46th St., New York, New York Co. ALPFIABETIOAL LIST OF FELLOWS, 813 Graves, Ezra, Amsterdam, Montgomery Co. Original. Gray, John P., 270 Alexander Ave., Rochester, Monroe Co. Gray, Joseph F., 326 W. 31st St., New York, New York Co. *Green, Caleb, Homer, Cortland Co. Founder. Green, H. H., Paine's Hollow, Herkimer Co. Green, Stephen S., 384 Swan St., Buffalo, Erie Co. Greene, Clark W., Chenango Forks, Broome Co. Greene, De Witt C., 1125 Main St., Buffalo, Erie Co. Original. Greene, Joseph C., 124 Swan St., Buffalo, Erie Co. Founder. Greene, Walter D., 444 Elk St., Buffalo, Erie Co. Original. Greenman, C. E., 575 1st St., Troy, Rensselaer Co. Gulick, A. Reading, 30 W. 36th St., New York, New York Co. Gulick, Charlton R., 30 W. 36th St., New York, New York Co. Guy, J. D., Coventry, Chenango Co. Hagadorn, William, Gilboa, Schoharie Co. Original. Halbert, M. L., Cincinnatus, Cortland Co. Hall, William H., Saratoga Springs, Saratoga Co. Original. Hamill, Edward H., 302 6th Ave., Newark, New Jersey. Hammer, Charles, Schenectady, Schenectady Co. Hammond, Frederick Porter, 157 E. 115th St., New York, New York Co. Hand, S. M., Norwich, Chenango Co. Hannan, James C., Hoosick Falls, Rensselaer Co. Founder. Harrington, D. W., 1430 Main St., Buffalo, Erie Co. Original. Harrison, George Tucker, 221 W. 23d St., New York, New York Co. Original. - Hartwig, Marcell, 34 E. Huron St., Buffalo, Erie Co. Harvie, J. B., 6 Clinton Place, Troy, Rensselaer Co. Founder. Hatch, C. A., 110 E. Onondaga St., Syracuse, Onomadaga Co. Original. Haubold, H. A., 225 E. 72d St., New York, New York Co. Hayd, Herman E., 78 Niagara St., Buffalo, Erie Co. Hayes, Philetus A., Afton, Chenango Co. Haynes, John U., 103 Mohawk St., Cohoes, Albany Co. Head, Adelbert D., 322 S. Salina St., Syracuse, Onondaga Co. Founder. Heath, William H., 415 Pearl St., Buffalo, Erie Co. Heimstreet, Thomas B., 14 Division St., Troy, Rensselaer Co. Original. Hendrick, Henry C., McGrawville, Cortland Co. Founder. Hepburn, Neil J., 369 W. 23d St., New York, New York Co. Hewitt, Adelbert, Saratoga Springs, Saratoga Co. Hicks, Edward E., Poughkeepsie, Dutchess Co. Hicks, W. Scott, Bristol, Ontario Co. Original. Higgins, F. W., Cortland, Cortland Co. Hillis, Thomas J., 51 Charlton St., New York, New York Co. Hills, Lyman H., Binghamton, Broome Co. Original. Himmelsbach, George A., 30 12th St., Buffalo, Erie Co. Hinton, John H., 41 W. 32d St., New York, New York Co. Founder. Hodgman, Abbott, 141 E. 38th St., New York, New York Co. Founder. *Deceased. 814 NEW YORK STATE MEDICAL ASSOCIATION. Hodgman, William H., 109 Caroline St., Saratoga Springs, Saratoga Co. Founder. Hogan, M. K., 226 W. 34th St., New York, New York Co. +Holcomb, O. A., Plattsburgh, Clinton Co. folden, Arthur L., 116 South St., Utica, Oneida Co. Holmes, Martha C., 75 W. 126th St., New York, New York Co. HoornBeek, Philip Du Bois, Wawarsing, Ulster Co. Original. (Retired list.) Horton, David B., Red Creek, Wayne Co. Hough, F. P., Binghamton, Broome Co. Houston, David W., 44.2d Street, Troy, Rensselaer Co. Original. Hovey, B. L., 34 N. Fitzhugh St., Rochester, Monroe Co. Founder. Howard, Charles F., 1458 Main St., Buffalo, Erie Co. Howland, George T., Athens, Greene Co. Hoyer, F. F., Tonawanda, Erie Co. Founder. Hubbard, Chauncey G., Hornellsville, Steuben Co. Hubbard, Dwight L., 344 W. 33d St., New York, New York Co. Hubbard, George E., 257 W. 52d St., New York, New York Co. Hubbard, Samuel T., 27 W. 9th St., New York, New York Co. Founder. Hubbell, Alvin A., 212 Franklin St., Buffalo, Erie Co. Hudson, George, Stillwater, Saratoga Co. Huestis, W. B., Kiskatom, Greene Co., Huggins, William Q., Sanborn, Niagara Co. Hughes, Henry R., Clinton, Oneida Co. Hughes, Peter, 275 Berry St., Brooklyn, Kings Co. Hulette, G. S., Arcade, Wyoming Co. Hühne, August, Rondout, Ulster Co. Founder. Hühne, Frederick, Rondout, Ulster Co. Original. Hull, Thomas H., 55 Lee Ave., Brooklyn, Kings Co. Hull, William H., Poestenkill, Rensselaer Co. Hulse, William A., Bay Shore, Suffolk Co. Humphrey, J. F., Saratoga Springs, Saratoga Co. Hunt, H. L., Orchard Park, Erie Co. Hunt, James G., 5 Gardner Block, Utica, Oneida Co. Original. *Hunt, James H., Port Jervis, Orange Co. Original, Hunter, Nathaniel P., Jasper, Steuben Co. Huntington, Henry K., New Rochelle, Westchester Co. Original. Huntington, John W., Mexico, Oswego Co. Huntley, James F., Oneida, Madison Co. *Husted, Nathaniel C., Tarrytown, Westchester Co. Founder, Ilgen, Ernst, 369 Herkimer St., Brooklyn, Kings Co. Original. Ingraham, Charles W., Binghamton, Broome Co. Ingraham, Henry D., 405 Franklin St., Buffalo, Erie Co. Ingraham, Samuel, Palmyra, Wayne Co. Original, (Retired list.) Inlay, Erwin G., Saratoga Springs, Saratoga Co. Jackson, Albert P., Oakfield, Genesee Co. Founder. Jackson, Charles W., 168 W. 81st St., New York, New York Co. *Deceased. ALPEIABETICAL LIST OF FELLOWS. 815. Jackson, William H., Springville, Erie Co. Jacobson, Nathan, 430 S. Salina St., Syracuse, Onondaga Co. Original. Jamison, John S., Hornellsville, Steuben Co. Original. Janeway, Edward G., 36 W. 40th St., New York, New York Co. Founder. Janvrin, J. E., 191 Madison Ave., New York, New York Co. * \. Jenkins, John A., 271 Jefferson Ave., Brocklyn, E.D., Kings Co. Original. Jenkins, William T., I09 E. 26th St., New York, New York Co. Jewett, F. A., 282 Hancock St., Brooklyn, Kings Co. Jewett, Homer O., Cortland, Cortland Co. Founder. Johnson, George P., Mexico, Oswego Co. Johnson, Ianthus G., Greenfield Centre, Saratoga Co. Original. Johnson, Leonard M., Greene, Chenango Co. Original. Johnson, Parley H., Adams, Jefferson Co. Original. Johnson, Richard G., Amsterdam, Montgomery Co. Original. Johnson, Thomas M., 418 Main St., Buffalo, Erie Co. Original. *Johnston, Francis U., New Brighton, Richmond Co. Founder. Johnston, Henry C., New Brighton, Richmond Co. Johnston, N. B., Barryville, Sullivan Co. Jones, Allen A., 436 Franklin St., Buffalo, Erie Co. Jones, George H., Fowlerville, Livingston Co. Jones, S. Case, 39 N. Fitzhugh St., Rochester, Monroe Co. Joslin, Albert A.,, Martinsburgh, Lewis Co. Judson, A. B., 38 E. 25th St., New York, New York Co. Julian, John M., Moore's Mill, Dutchess Co. Keefer, Charles W., Mechanicsville, Saratoga Co. Keith, Halbert Lyon, Upton, Mass. Relly, John Devin, Lowville, Lewis Co. Kemp, William M., 267 W. 23d St., New York, New York Co. Kenyon, Benjamin, Cincinnatus, Cortland Co. Kenyon, M., King's Ferry, Cayuga Co. Original. Kilborn, Henry F., Croghan, Lewis Co. King, Ferdinand, 315 W. 58th St., New York, New York Co. King, James K., Watkins, Schuyler Co. Kingsley, Henry F., Schoharie, Schoharie Co. Original. Kittredge, Charles S., Fishkill-on-Hudson, Dutchess Co. Founder. Klock, Charles M., St. Johnsville, Montgomery Co. Knapp, W. H., Binghamton, Broome Co. Kneeland, B. T., Dalton, Livingston Co. Kneeland, Jonathan S., Onondaga, Onondaga Co. Founder. (Retired list.) Kneer, F. G., 236 W. 51st St., New York, New York Co. Knipe, George, 354 W. 24th St., New York Co. Kniskern, A. C., Mechanicsville, Saratoga Co. Kuhn, William, Rome, Oneida Co. LaBell, Martin J., Lewis, Essex Co. Original. Laird, William R., 98 Wall St., Auburn, Cayuga Co. Original. *Deceased, 816 NEW YORK STATE MEDICAL ASSOCIATION. Lake, Albert D., Gowanda, Cattaraugus Co. *Lamb, Milton M., Lansingburgh, Rensselaer Co. Lambert, John, Salem, Washington Co. Landon, Newell E., Newark, Wayne Co. Original. Lapp, Henry, Clarence, Erie Co. Leach, H. M., Charlton City, Massachusetts. Original. Leale, Charles A., 604 Madison Ave., New York, New York Co. Founder. Leaning, John K., Cooperstown, Otsego Co. Founder. Leffingwell, E. D., Watkins, Schuyler Co. Leighton, N. W., 143 Taylor St., Brooklyn, E. D., Kings Co. Original. Le Roy, Irving D., Pleasant Valley, Dutchess Co. Founder. Lester, Elias, Seneca Falls, Seneca Co. Founder. Lewis, Robert, 19 E. 38th St., New York, New York Co. Lindsay, Walter, Huntington, Suffolk Co. Original. Little, Albert H., 158 W. 20th St., New York, New York Co. Little, Frank, 114 Montague St., Brooklyn, Kings Co. Lloyd, T. Mortimer, 125 Pierrepont St., Brooklyn, Kings Co. Original. Lockwood, Charles E., 59 W. 36th St., New York, New York Co. Lockwood, J. W., Philmont, Columbia Co. Original. Long, Alfred J., Whitehall, Washington Co. Long, Ben G., 1408 Main St., Buffalo, Erie Co. Ludlow, Ogden C., 210 W. 135th., New York, New York Co. Lukens, Anna, 1068, Lexington Ave., New York, New York Co. Lung, Jesse B., 382 Marion St., Brooklyn, Kings Co. Original. Lusk, William T., 47 E. 34th St., New York, New York Co. Founder. Lusk, Zera J., Warsaw, Wyoming Co. Lyman, Elijah S., Sherburne, Chenango Co. Original. Lyman, H. C., Sherburne, Chenango Co. Original. Lynch, Patrick J., 216 E. 13th St., New York, New York Co. Lyon, E. M., Plattsburgh, Clinton Co. Founder. Lyon, George E., 1915 5th Ave., Troy, Rensselaer Co. Original. Lyons, Edward L., 298 4th St., Troy, Rensselaer Co. Lyons, G. A., New Rochelle, Westchester Co. Original. Macfarlane, William A., Springville, Erie Co. MacGregor, James R., 1125 Madison Ave, New York, New York Co. Mackenzie, J. C., 432 W. 22d St., New York, New York Co. Magee, Charles M., West and Seymour Sts., Syracuse, Onondaga Co. Magee, Daniel, 1163d St., Troy, Rensselaer Co. Original. Maine, Alvah P., Webster, Monroe Co. Manley, Thomas H., 302 W. 53d St., New York, New York Co. Founder. Marsh, E. Frank, Fulton, Oswego Co. Marsh, James P., 1739 5th Ave., Troy, Rensselaer Co. Marshall, Francis F., 56 W. 56th St., New York, New York Co. Martin, John H., Otsego, Otsego Co. Original. Martindale, F. E., Port Richmond, Richmond Co. Martine, Godfrey R., Glens Falls, Warren Co. Original, *Deceased. AIPHABETICAL LIST OF FELLOWS. 817 *Matthews, David, 73 E. 54th St., New York, New York Co. *Maury, Rutson, 252 Madison Ave., New York, New York Co. McBurney, Charles, 28 W. 37th St., New York, New York Co. McCollom, William, 195 Lefferts Place, Brooklyn, Kings Co. Original. McDonald, George E., Schenectady, Schenectady Co. Original. McDougall, R. A., Duanesburgh, Schenectady Co. McDougall, William D., Spencerport, Monroe Co. (San José, Cal.) McEwen, Robert C., Saratoga Springs, Saratoga Co. Founder. McGann, Thomas, Wells, Hamilton Co. McGillicuddy, T. J., 776 Madison Ave., New York, New York Co. McGowen, John P., 137 E. 28th St., New York, New York Co. McIlroy, Samuel H., 330 Alexander Ave., New York Co. McLeod, Johnston, 247 W. 23d St., New York, New York Co. McLeod, S. B. Wylie, 247 W. 23d St., New York, New York Co. Founder. - McLochlin, James A., 410 E. 10th St., New York, New York Co. Original. McNamara, Daniel, 243 W. Genesee St., Syracuse, Onandaga Co. Original. McNamara, Laurence J., 126 Washington Place (West), New York, New York Co. Original. McPherson, George W., Lancaster, Erie Co. McWilliams, F. A., Monticello, Sullivan Co. Meacham, Isaac D., Binghamton, Broome Co. Meier, Gotlieb C. H., 210 E. 53d St., New York, New York Co. Menzie, R. J., Caledonia, Livingston Co. Original. Merritt, George, Cherry Valley, Otsego Co. Original. Miller, William T., 310 W. 27th St., New York, New York Co. Original. Milliken, S. E., 157 Madison Ave., New York, New York Co. Minard, E. J. Chapin, 243 Quincy St., Brooklyn, Kings Co. Orignal. Miranda, Ramon L., 349 W. 46th St., New York, New York Co. Original. Mitchell, Howard E., 84 Fourth St., Troy, Rensselaer Co. Founder. Mitchell, Hubbard W., 747 Madison Ave., New York, New York Co. Original. Moore, Edward M., 74 S. Fitzhugh St., Rochester, Monroe Co. Founder. Moore, Edward M., Jr., 74 S. Fitzhugh St., Rochester, Monroe Co. Original. Moore, Richard Mott, 74 S. Fitzhugh St., Rochester, Monroe Co. Original. Moore, William A., Binghamton, Broome Co. Moran, James, 352 W. 51st St., New York, New York Co. Moriarta, Douglas C., Saratoga Springs, Saratoga Co. Morrow, William B., Walton, Delaware Co. Mott, Valentine, 62 Madison Ave., New York, New York Co. Moyer, Frank H., Moscow, Livingston Co. Original. Mudge, Selden J., Olean, Cataraugus Co. Munger, Charles, Knoxborough, Oneida Co. Munson, J. A., Woodbourne, Sullivan Co. Original. Munson, W. W., Otisco, Onondaga Co. Original. *Deceased. 818 IVEW YORK STATE MEDICAL ASSOCIATION. Murdoch, James Bissett, 4232 Fifth Ave., Pittsburgh, Pa. (Non-resident.) Murdock, George W., Cold Spring, Putnam Co. Founder. Murphy, John, 219 E. 37th St., New York, New York Co. Original. Murray, Byron J., Saratoga Springs, Saratoga Co. Original. Murray, S.J., 133 W. 87th St., New York, New York Co. Original. Murray, William D., Tonawanda, Erie Co. Original. Nelson, William H., Taberg, Oneida Co. Newman, George W., 234 Leonard St., Brooklyn, Kings Co. Newman, Robert, 68 W. 36th St., New York, New York Co. Original. Nichols, Calvin E., 25 First St., Troy, Rensselaer Co. Founder. - Nichols, H. W., Canandaigua, Ontario Co. Founder. Nichols, William H., West Sand Lake, Rensselaer Co. Founder. Nicholson, A. R., Madison, Madison Co. Original. Nicoll, Henry D., 51 E. 57th St., New York Co. Founder. Nold, John B., 165 North Ave., Rochester, Monroe Co. North, Nelson L., 627 Bedford Ave., Brooklyn, Kings Co. Original. Nutten, Wilbur F., Newark, Wayne Co. Oberndorfer, Isidor P., 1037 Lexington Ave., New York, New York Co. Original. O’Brien, Frederick Wm., 234 E. 112th St., New York, New York Co. O’Brien, M. Christopher, 161 W, 122d New York, New York Co. Ochs, Benjamin F., 773 Lexington Ave., New York, New York Co. O'Hare, Thomas A., 157 State St., Rochester, Monroe Co. Original. Oliver, William, Penn Yan. Yates Co. Oppenheimer, H. S., 49 E. 23d St., New York, New York Co. Oppenheimer, S., 533 E. 120th St., New York, New York Co. Orton, John G., Binghamtom, Broome Co. Founder. Ostrander, George A., 61 Greene Ave., Brooklyn, Kings Co. Packer, Thurston G., Smyrna, Chenango Co. Paine, Arthur R., 99 Lafayette Ave., Brooklyn, Kings Co. Original. Palmer, Edmund J., 1842 Lexington Ave., New York, New York Co. Palmer, F. A., Mechanicsville, Saratoga Co. Palmer, George M., Warsaw, Wyoming Co. Original. Palmer, Henry C., cor. Genesee and Hopper Sts., Utica, Oneida Co. Palmer, Walter B., 30 South St., Utica, Oneida Co. Parent, J. S., Birchton, Saratoga Co. Park, Roswell, 510 Delaware Ave., Buffalo, Erie Co. Parr, John, Buel, Montgomery Co. Parsons, Israel, Marcellus, Onondaga Co. Founder. Parsons, John, Kingsbridge, New York, New York Co. Original. Parsons, W. W. D., Fultonville, Montgomery Co. Pease, Joseph, Hamlin, Monroe Co. Original. Perry, John Gardner. 48 E. 34th St., New York, New York Co. Perry, Nathaniel M., Troupsburgh, Steuben Co. Original. Peters, Samuel, 86 Mohawk St., Cohoes, Albany Co. Founder. Pettit, John A., 519 Swan St., Buffalo, Erie Co. Original. Phelan, Michael F., 339 Congress St., Troy, Rensselaer County. ALPEIA BETIONAL LIST OF FELLOWS. 819 Phelps, Charles, 34 W. 37th St., New York, New York Co. Phelps, George G., 239 Blandina St., Utica, Oneida Co. Phelps, William C., 146 Allen St., Buffalo, Erie Co. Pierce, Edward A., Binghamton, Broome Co. Pierson, George E., Kirkwood, Broome Co. Pilgrim, Charles W., State Hospital, Willard, Seneca Co. Original. Piper, Charles W., Wurtsborough, Sullivan Co. Place, John F., Jr., Binghamton, Broome Co. Pohlman, Julius, 539 Niagara St., Buffalo, Erie Co. *Pollard, Abiathar, Westport, Essex Co. Original. (Retired list.) Pooler, Hiram A.,, 34 Gramercy Park, New York, New York Co. Original. (Retired list.) Porteous, James G., Poughkeepsie, Dutchess Co. Founder, Porter, Harry N., 1910 Harewood Ave., Washington, D. C. Founder. (Retired list.) Porter, P. Brynberg, 8 W. 35th St., New York, New York Co. Original. Potter, Vaughn C., Starkville, Herkimer Co. Original. Potts, E., Port Jervis, Orange Co. Pray, S. R., 523 Bedford Ave., Brooklyn, Kings Co. Original. Preston, John R., Schuylerville, Saratoga Co. Original. Price, Henry R., 485 Franklin Ave., Brooklyn, Kings Co. Prince, Alpheus, Byron, Genesee Co. Pritchard, R. L., 72 W. 49th St., New York, New York Co. Pultz, Monroe T., Stanfordville, Dutchess Co. Founder. Purple, Samuel S., 36 W. 22d St., New York, New York Co. Founder. Putnam, Frederick W., Binghamton, Broome Co. Founder. Putnam, James W., 388 Franklin St., Buffalo, Erie Co. Original. Quin, Hamilton S., 171 Genesee St., Utica, Oneida Co. Race, W. F., 115 W. 25th St., Kearney, Nebraska. Original. Rae, Robert, Portageville, Wyoming Co. Original. Rand, Hannibal W., Keene, Essex Co. Original. Ransom, H. B. (in 'care S. W. White and Co.), 36 Wall St., New York, New York Co. Rau, Leonard S., 72 W. 55th St., New York, New York Co. Rave, Edward G., Oyster Bay, Queens Co. Original. Raynor, F. C., 163 Clinton St., Brooklyn, Kings Co. Read, Ira B., 66 E. 126th St., New York, New York Co. Reagles, James, Schenectady, Schenectady Co. Original. Reed, Henry B., 12 Verona Place, Brooklyn, Kings Co. Reid, Christopher C., Rome, Oneida Co. Reitz, Charles, Webster, Monroe Co. Reynolds, Tabor B., Saratoga Springs, Saratoga Co. Founder. Rice, George, Mechanicsville, Saratoga Co. Richards, Charles B., Binghamton, Broome Co. Founder. Richardson, John E., 127 S. Oxford St., Brooklyn, Kings Co. * Deceased, 52 820 NEW YORK STATE MEDICAL ASSOCIATION. Richmond, Nelson G., Fredonia, Chautauqua Co. Ricketts, Benjamin M., 137 Broadway, Cincinnati, Ohio. Original. Riley, Andrew W., 207 S. 16th St., Omaha, Neb. Original. Risch, Henry F. W., 521 3d St., Brooklyn, Kings Co. Robb, William H., Amsterdam, Montgomery Co. Founder. Robinson, Ezra A., Geneva, De Kalb Co., Ill. Original. Rochester, De Lancey, 469 Franklin St., Buffalo, Erie Co. Rochester, Thomas M., 326 DeKalb Ave., Brooklyn, Kings Co. Rodgers, Harris 6., 1 Wall St., Binghamton, Broome Co. Rogers, S. Frank, 31616th Ave., Troy, Rensselaer Co. Original. Rolph, R. T., Fredonia, Chautauqua Co. Roper, P. B. Alpine, Schuyler Co. Ross, Frank W., 251 Baldwin St., Elmira, Chemung Co. Original. Roth, Julius A., 308 E. 79th St., New York, New York Co. Rousseau Zotique, 99 2d St., Troy, Rensselaer Co. Founder. Rudgers, Denton W., Perry, Wyoming Co. Ruggles, Augustus D., 239 W. 14th St., New York, New York Co. Rulison, Elbert T., Amsterdam, Montgomery Co. Original. Rulison, L. B., West Troy, Albany Co. Rushmore, John D., 129 Montague St., Boooklyn, Kings Co. Founder. Russell, Charles P., 198 Genesee St., Utica, Oneida Co. Russell, William G., 27 McDonough St., Brooklyn, Kings Co. Original. Sabin, William B., 1425 Broadway, West Troy, Albany Co. Founder. Sabine, Gustavus A., 8 E. 24th St., New York, New York Co. Original. Sanders, E., 126 E. 82d St., New York, New York Co. Sawyer, Conant, Auburn, Cayuga Co. Founder. Saxer, Leonard A., 514 Prospect Ave., Syracuse, Onondaga Co. Original. Sayre, Lewis A., 285 Fifth Ave., New York, New York Co. Founder. Sayre, Reginald H., 285 Fifth Ave., New York, New York Co. Schmid, H. Ernst, White Plains, Westchester Co. Original. Schopp, Justin H., 127 E. Main St., Rochester, Monroe Co. Scully, Thomas P., Rome, Oneida Co. Seaman, Louis L., 18 W. 31st St., New York, New York Co. Seaman, Frank G., Seneca Falls, Seneca Co. Sears, F. W., 326 Montgomery St., Syracuse, Onondaga Co. Segur, Avery, 281 Henry St., Brooklyn, Kings Co. Founder. Selden, O. G., Catskill, Greene Co. Original. Selden, Robert, Catskill, Greene Co. Original. Seymour, Ralph A., Whitney’s Point, Broome Co. Seymour, W. Wotkyns, 105 3d St., Troy, Rensselaer Co. Founder, Sharer, John P., Little Falls, Herkimer Co. Original. Shaw, Henry B., 21 E. 127th St., New York, New York Co. Shea, Dennis L., 116 Waverly Place, New York, New York Co. Shepard, A. Warner, 126 Willoughby St., Brooklyn, Kings Co. Original. Sherer, John D., Waterford, Saratoga Co. Original. Sherman, F. J., Ballston, Saratoga Co. Shrady, John, 149 W. 126th St., New York, New York Co. ALPEIABETICAL LIST OF FELLOWS. 821 Shrady, John Eliot, 149 W. 126th St., New York, New York Co. Shunk, Albert, 232 W. 22d St., New York, New York Co. Silver, Henry M., 39 7th St., New York, New York Co. Simmons, Charles E., 742 Lexington Ave., Brooklyn, Kings Co. Simmons, E. W., Canandaigua, Ontario Co. Founder. (Retired list.) Simons, Frank E., Canajoharie, Montgomery Co. Sizer, Nelson Buell, 336 Greene Ave., Brooklyn, Kings Co. Original. Skinner, Smith A., Hoosick Falls, Rensselaer Co. Original. Slater, Frank Ellsworth, Binghamton, Broome Co. Small, John W., New Rochelle, Westchester Co. Smeallie, James A., 12 W. 40th St., New York, New York Co. Smelzer, Baxter T., Havana, Schuyler Co. Smith, F. A., Corinth, Saratoga Co. Smith, George C., Delhi, Delaware Co. Smith, H. Lyle, Hudson, Columbia Co. Original. Smith, J. Lewis, 64 W. 56th St., New York, New York Co. Original. Smith, Samuel L., Smithville Flats, Chenango Co. Smith, Samuel W., 24 W. 30th St., New York, New York Co. Original. Smith, Stephen, 574 Madison Ave., New York, New York Co. Original. Smyth, Arthur W. H., Amsterdam, Montgomery Co. Snook, George M., Parma, Monroe Co. Southworth, Malek A., Little Falls, Herkimer Co. Original. Southworth, Richmond Joseph, 1220 36th St., N. W., Washington, D. C. Original. Spicer, Walter E., 41 N. Moore St., New York, New York Co. Sprague, John A., Williamson, Wayne Co. Original. Sprague, L. S., Williamson, Wayne Co. (Retired list.) Squibb, Edward H., 148 Columbia Heights, Brooklyn, Kings Co. Founder. Squibb, Edward R., 152 Columbia Heights, Brooklyn, Kings Co. Founder. Squire, Charles L., 409 E. Church St., Elmira, Chemung Co. Steinke, Carl Otho Hermann, 220 17th St., Brooklyn, Kings Co. Original. Stephenson, F. Halleck, 101 Warren St., Syracuse, Onondaga Co. Stephenson, James A., Scio, Allegany Co. Original. Stewart, F. E., Watkins, Schuyler Co. Stockschlaeder, P., 186 South Ave., Rochester, Monroe Co. Stockton, Charles G., 436 Franklin St., Buffalo, Erie Co. Stone Frank L., Le Roy, Genesse Co. Strong, Orville C., Colden, Erie Co. Strong, Thomas D., Westfield, Chautauqua Co. Founder. Stubbs, Roland H., Waterford, Saratoga County. Original. Sullivan, John D., 74 McDonough St., Brooklyn, Kings Co. Sutton, H. C., Rome, Oneida Co. Sutton, Richard E., Rome, Oneida Co. Swan, William E., Saratoga Springs, Saratoga Co. 822 NEW YORK STATE-MEDICAL ASSOCIATION. Swamick, R. A., Saratoga Springs, Saratoga County. Swartwout, H. B., Port Jervis, Orange Co. Swartwout, Leander, Prospect, Oneida Co. Sweet, Joseph J., Unadilla, Otsego Co. Original. Sweet, Joshua J., Unadilla, Otsego Co. - Sweetman, J. T., Jr., Ballston, Saratoga Co. Taber, R. C., Tonawanda, Erie Co. Taylor, John H., Holley, Orleans Co. Original. Tefft, Charles B., Room 20, Arcade, Utica, Oneida Co. Thomas, T. Gaillard, 600 Madison Ave., New York, New York Co. Founder. Thompson, R. A., Norwich, Chenango Co. Thompson, Amos W., Saratoga Springs, Saratoga County. Thompson, Von Beverhout, 111 W. 43d St., New York, New York Co. Thornton, William H., 572 Niagara St., Buffalo, Erie Co. Thwing, Clarence, Sitka, Alaska. Tiemann, Paul E., 161 W. 104th St., New York, New York Co. Todd John B., Parish, Oswego Co. Tompkins, Fred J., 1282d Ave., Lansingburgh, Rensselaer Co. Tompkins, H. C., Knowlesville, Orleans Co. Founder. Tompkins, Orren A., East Randolph, Cattaraugus Co. Original. Townsend, Charles E., Middletown, Orange Co. Townsend, Morris W., Bergen, Genesee Co. Founder. Traver, Richard D., 144th St., Troy, Rensselaer Co. Original. Travis, Edward M., Masonville, Delaware Co. Tremaine, Wm. S., 217 Franklin St., Buffalo, Erie Co. Founder. Tripp, John D., Auburn, Cayuga Co. Original. Truax, J. G., 17 E. 127th St., New York, New York Co. Trull, H. P., Williamsville, Erie Co. . Tucker, Carlos P., 43 W. 26th St., New York, New York Co. Founder. Turner, Melvin H., Moriah, Essex Co. Original. Twohey, John J., 170 E. Utica St., Buffalo, Erie Co. Wanderhoof, Frederick D., Phelps, Ontario Co. Original. Wanderveer, J. C., Monroe, Orange Co. Wanderveer, J. R., Monroe, Orange Co. Van de Warker, Ely, 104 Fayette Park, Syracuse, Onondaga Co. Founder. Wan Fleet, Frank, 158 E. 81st St., New York, New York Co. Van Hoevenberg, Henry, Kingston, Ulster Co. Original. Van Vranken, Adam T., 1603 3d Ave., West Troy, Albany Co. Original. Van Wagner, L. A., Sherburne, Chenango Co. Van Wyck, Richard C., Hopewell Junction, Dutchess Co. Original. Van Zandt, Henry C., Schenectady, Schenectady Co. Original. Warney, Miles E., Saratoga Springs, Saratoga Co. Wedder George W., Philmont, Columbia Co. Weeder, Andrew T., Schenectady, Schenectady Co. Won Dönhoff, Edward, 210 W. 4th St., New York, New York Co. ALPHABETICAL LIST OF FELLOWS, 823 Vincent, Ludger C., 52 W. 26th St., New York, New York Co. Wagner, Charles Gray, State Hospital, Binghamton, Broome Co. Wakeley Benjamin C., Angelica, Allegany Co. Original. Wales, Theron A., Elmira, Chemung Co. Original. Wall, Charles A., 306 Hudson St., Buffalo, Erie Co. Wallace, Edwin E., Jasper, Steuben Co. Wallach, Joseph G., 7 W. 82d St., New York, New York Co. Original. Walser, William C., Port Richmond, Richmond Co. Walsh, Simon J., 9 E. 129th St., New York, New York Co. Ward, Charles S., 30 W. 33d St., New York, New York Co. Founder. Ward, John J., Ellenville, Ulster Co. Ward, R. H., 534th St., Troy, Rensselaer Co. Warner, Frederic M., 66 W. 56th St., New York, New York Co. Warner, John W., 107 E. 72d St., New York, New York Co. Waterworth, William, 3 Hancock St., Brooklyn, Kings Co. Webster, W. B., Schuylerville, Saratoga Co. Weeks, John E., 154 Madison Ave., New York, New York Co. Welles, S. R., Waterloo, Seneca Co. Wells, E. H., Binghamton, Broome Co. Wells, William L., New Rochelle, Westchester Co. Original, West, Joseph E., 171 Genesee St., Utica, Oneida Co. *West, M. Calvin, Rome, Oneida Co. Weston, Albert T., 226 Central Park West, bet. 82d and 83d Sts., New York, New York Co. Wheeler, Isaac G., Marilla, Erie Co. Wheeler, John T., Chatham, Columbia Co. Whippler, Electa B., 491 Porter Ave., Buffalo, Erie Co. White, Charles B., 107 W. 72d St., New York, New York Co. White, J. Blake, 1013 Madison Ave., New York, New York Co. White, Whitman W., 1024 Park Ave., New York, New York Co. Founder. White, William T., 130 E. 30th St., New York, New York Co. Founder. Whitford, James, Onondaga Valley, Onondaga Co. Original. Wieber George, 181 South 5th St., Brooklyn, Kings Co. Original. Wiener, Joseph, 1046 5th Ave., New York, New York Co. Founder. Wiggin, Frederick Holme, 55 W. 36th St., New York, New York Co. Williams, George O., Greene, Chenango Co. Williams, Henry Smith, Randall's Island, New York, New York Co. Williams, William H., 207 17th St., Brooklyn, Kings Co. Original. Williamson, Edward A., Westchester Road, Westchester Co. Willoughby, M., 1335 Main St., Buffalo, Erie Co. Wilson, Thomas, Claverack, Columbia Co. Founder. Witbeck, Charles E., Cohoes, Albany Co. *Woodend, William D., Huntingdom, Suffolk Co. Founder. Woodend, William E., 171 E. 116th St., New York, New York Co. Woodruff, E. Gould, Watkins, Schuyler Co. Woodruff, R. Allen, Philmont, Columbia Co. *Deceased 824 NEW YORK STATE MEDICAL ASSOCIATION. Woodworth, T. Floyd, Kinderhook, Columbia Co. Wright, Theodore Goodell, Plainville, Hartford Co., Conn. (Non-resi- dent.) Wyckoff, Cornelius C., 482 Delaware St., Buffalo, Erie Co. Founder. Wyckoff, Richard M., 532 Clinton Ave., Brooklyn, Kings Co. Founder. Wyeth, John A., 27 E. 38th St., New York, New York Co. Original. Young, Augustus A., Newark, Wayne Co. Original. Young, John, Fishkill-on-Hudson, Dutchess Co. Original. Young, John D., Starkville, Herkimer Co. Original. Young, William, Cold Spring, Putnam Co. Founder. (Retired list). Zeh, Edgar, Waterford, Saratoga Co. Zeh, Merlin J., 1521 Broadway, West Troy, Albany Co. Of 164 Founders, 116 remain on the list ; of 286 Original Fellows, 228 remain on the list. Total Fellowship, 800. RETIRED FELLOWS. Charles G. Bacon, Fulton, Oswego County (1891). M. M. Bagg, Utica, Oneida County (1891). George B. Banks, Hartsdale, Westchester County (1892). Lyman Barton, Willsborough, Essex County (1890). F. R. Bentley, Cheshire, Ontario County (1891). William N. Bonesteel, Troy, Rensselaer County (1890). Alonzo Churchill, Utica, Oneida County (1890). C. L. Dayton, Buffalo, Erie County (1891). *James Ferguson, Glens Falls, Warren County (1891). Philip DuB. Hoorn Beek, Wawarsing, Ulster County (1891). Samuel Ingraham, Palmyra, Wayne County (1890). Jonathan S. Kneeland, Onondaga County (1890). *Abiathar Pollard, Westport, Essex County (1890). H. A. Pooler, 34 Gramercy Park, New York, New York County (1892). H. N. Porter, Washington D. C. (1891). E. W. Simmons, Canandaigua, Ontario County (1892). L. S. Sprague, Williamson, Wayne County (1891). William Young, Cold Spring, Putnam County (1891), * Deceased. NON-RESIDENT FELLOWS. James Bissett Murdoch, M.D., 4232 Fifth Ave., Pittsburgh, Pa. Theodore Goodell Wright, M.D., Plainville, Hartford County, Conn. HONORARY FELLOWS. Sir John Simon, 40 Kensington Square, London, England (1890). CORRESPONDING FELLOWS, William Goodell, M.D., 1418 Spruce St., Philadelphia, Pa. (1890). Henry O. Marcey, M.D., 116 Bolyston St., Boston, Mass (1890). DECE ASED FELLOWS. YEAR of , NAME. AGE. County. PLACE OF BIRTH. DATE OF DEATH. MEDICAL COLLEGE. GRAD- UATION. Adams, John G. (F)+ . . 77 ||New York . . |New York City . . . . June 19, 1884. Coll. Phys. and Surg., N. Y. . 1830 Allaben, O. M. (O)* . . . . 83 |Delaware . . . . . . . . . . . . . . . . . . . . . . . . . . Nov. 27, 1891. . . . . . . . . . . . . . . . . . . . . . . . . . . . . tº e º e Andrews, John S. (O) . , | 61 |Kings . . . [Bristol, Conn. . . . . Jan. 3, 1889. Univ. City of New York . . 1849 Ashton, Isaiah H. . . . . 39 Westchester . Philadelphia, Pa. . . . [Feb. 16, 1889. University of Pennsylvania . 1870 Avery, George W. (F) . . . 61 |Chenango . . Earlville, N. Y. . . . . [Nov. 1, 1888. Albany Medical College . . . 1850 Ayres, Alexander (F) . . 74 |Montgomery . Oppenheim, N. Y. . . . Aug. 27, 1886. Castleton, Vt. . . . . . . 1842 Babcock, Myron N. (F) . . 73 Saratoga. . . West Berkshire, Vt. . . [May 21, 1892. Vermont Medical College Barker, A. M. (O). . . . . 37 |Erie . . . . Kendall, Orleans Co., N.Y. Dec. 6, 1887. University of Buffalo . . . 1877 Bathgate, James (O) . . . 65 |New York . . New York. . . . . . March 27, 1891. Coll. Phys. and Surg., N. Y. . 1846 Baynes, William T. (O) . . . . . Rensselaer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Bemus, William P. . . . 63 |Chautauqua . Chautauqua Co. . . . . [Sept. 19, 1890. Berkshire Medical College . . 1847 Blakeman, William N. (O). 85 |New York . . Roxbury, Conn. . . . . Aug. 10, 1890. Yale . . . . . . . . . 1832 Bucklin, Daniel D. (O) . . 70 Rensselaer . . [Brunswick, N. Y. . . . April 19, 1890. Albany Medical College . . . 1846 Budd, J. Henry (O) . . . . 45 Ontario . . . United States. . . . . [Feb. 25, 1890. Buffalo Medical College . . . 1875 Burwell, George N. (O) . . . . . [Erie . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . University of Pennsylvania . e tº e e Case, Mary W. . . . . . 33 Rensselaer . . |New York State . . . . [Aug. 19, 1889. Women’s Med. Coll., Phila. . 1882 Chace, William (F) . . . 58 Chautauqua . St. Catharine's, Canada . Dec. 27, 1891. Coll. Phys. and Surg., N. Y. . 1858 . Church, Allen S. (F) . . . . 62 |New York . . Great Barrington, Mass. . [Oct. 24, 1884. Castleton, Vt. 1848 Clark, Alonzo . . . . . 80 ||New York . . Chester, Mass. . . . [Sept. 13, 1887. Coll. Phys. and Surg., N. Y. . 1835 º Clark, Simeon T. (O) . . ... [Niagara . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . e e e Coit, William N. (F). . . 52 Clinton . . . |Plattsburgh, N. Y. . . [Aug. 4, 1886. University of Pennsylvania. . 1856 Collins, Isaac G. (F) . . . 53 Westchester Granville, N. Y. . . . . [Dec. 18, 1885. Albany Medical College . . . 1858 DECEASED FELLOWS. • e º e e a e e s e t e e s e e s e e s a e º e * * * * * * * * * * * * * * 1 (F) Founder. 8 (O) Original Fellow. 1851 1860 1880 1852 1850 1840 1860 1829 1835 1848 1858 1864 1878 1841 1833 1845 1855 1861 1836 1846 1849 1856 1844 1878 1850 1869 1877 Collins, Thomas B. (O) . Cooper, William S. (F) . Cornell, F. O. (O). Cotes, J. R. . Creamer, Joseph . Cruttenden, Albert G. Damainville, Lucien . . Davidson, John (F) De La Mater, S. G. (F) . Du Bois, Abram (F) . Eager, William B. (O) Earll, George W. (F). Edgerly, Edward F. (F) Elder, Jennie S. tº ſº Ferguson, James (O). Flint, Austin (F) & ºt Flood, Patrick Henry (O) Fox, Eli . . . . . . Fuller, Winfield S. (O) . Garrish, John P. (O) . Gay, Charles C. F. (F) . Gray, John Perdue (F) . Gray, John W. (F) Green, Caleb (F) Griswold, Gaspar (O) Guernsey, Desault (F) Hall, H. C. (O). Hall, John E. (O). 61 70 29 54 75 52 91 73 81 65 53 50 32 74 73 72 57 48 76 66 61 53 73 29 55 41 38 Monroe . Rensselaer . Montgomery . . |Batavia, N. Y. Genesee . Kings Ontario . New York . Queens . Schenectady New York . Orange . Onondaga . Essex Onondaga . Warren . New York . Chemung . Herkimer Monroe . New York . Erie . Oneida . Livingston . Cortland New York . Dutchess Broome . Albany . . Mendon, N. Y. . . Scotland . Covington, N. Y. . Erie, Pa. tº e . |New York City . . . . Bethlehem, Alb. Co., N.Y. . Red Hook, N. Y. . Orange Co. . . . |Mottville, N. Y. . Moriah, Essex Co. . . Syracuse, N. Y. . , Kortright, N. Y. . Petersham, Mass. . Pennsylvania . Columbia, N. Y. . Walworth, N. Y. . Pittsfield, Mass. . . Half Moon, Pa. . . America tº tº . |La Fayette, N. Y. . . |New York City . |America • * * . |New Marlboro’, Mass. . Glenville, N. Y. . . . tº gº tº º e º 'º º tº º e º e º 'º e º gº ſe e º 'º New Brunswick, N. J. Wilton, N. Y. . Feb. 17, 1888. . |May 26, 1890. . |Dec. 3, 1884. . |March 20, 1884. tº º $ tº e º º ºs e º 'º e º º . June 7, 1890. . |Dec. 15, 1891. . Dec. 26, 1884. June 23, 1888. . Aug. 29, 1891. . Jan. 18, 1890. . July 8, 1890. . June, 23, 1889. . |Feb. 2, 1889. . Oct. 27, 1892. . |March 13, 1886. . |March 12, 1886. ... [Oct. 13, 1890. . Jan. 13, 1888. . April 1, 1891. . |March 27, 1886. . |Nov. 29, 1886. . April 17, 1886. . |May 10, 1893. . |March 4, 1886. . Dec. 9, 1885. . |June, 1, 1887. Nov. 3, 1886. Jefferson Med. Coll., Phila. Albany Medical College Albany Medical College Med, Dep. Univ., Buffalo . Coll. Phys. and Surg., N. Y. . Willoughby Univ., Ohio Long Island Coll. Hosp. Lic. N. Y. St. Med. Soc. Albany Medical College Coll. Phys. and Surg., N. Y. . Coll. Phys. and Surg., N. Y. . Buffalo Medical College. Albany Medical College. Med. Dept. Syracuse Univ. Castleton, Vt. e e º º Harvard Medical College Geneva Medical College. Med. Dept. Univ. City of N. Y. Coll. Phys. and Surg., N. Y. . Jefferson Med. Coll., Phila. Berkshire Medical College . University of Pennsylvania University of New York Geneva Medical College. & Bellevue Hospital Med. Coll. . Coll, Phys. and Surg., N. Y. . University of New York Albany Medical College DECEASED FELLOWS.— Continued NAME. AGE. County. PLACE of BIRTH. Hamilton, Frank H. (F) 73 ||New York . . [Wilmington, Vt. Higgins, Seabury M. (O) 67 |Onondaga. . . |Brewster, Mass. . . . Hinds, Frederic J. (O) 32 Washington . East Greenwich, N. Y. Hollister, Edwin O. (O). 41 |Ontario . . |Batavia, N. Y. Hunt, James EI. (O) . 66 |Orange . & e º 'º sº e º e s = e s e º ºs º e º & tº e º ºs e e Husted, N. C. (F). * ... Westchester . Round Hill, Conn. . Hutchison, Joseph C. (F) 60 |Kings . |Old Franklin, Mo. . Hyde, Frederick (F). 80 |Cortland . Whitney Point, N. Y. . Johnston, Francis U. (F) 66 |Richmond . . New York City . , King, James E. (O) 66 Erie . . Warren, Pa. . . g Knapp, Edwin A. (O) 67 |Onondaga . . New York State Knapp, John H. (O) . 67 |Cortland . |New Fairfield, Conn. . Lamont, John Campbell, 47 |Wayne . . . [Edinburgh, Scotland . Lauer, Eugene (O) e 40 ||New York . . [Germany . Lester, Sullivan W. (O) . 40 ||Rensselaer . . Niantic, Conn. Linsly, Jared (F) . 84 ||New York . . [Northfield, Conn. Matthews, David . ... New York . . . . . . . . . . . . . . . . . . . . . . . . . . Maury, Rutson . . . . . . . . . New York . . . . . . . . . . . . . . . . . . . . . . . . . McClellan, Christopher R. . 73 ||Kings . |Maryland . McTammany, George H. . 31 |Rensselaer . . Troy, N. Y. McTammany, Wm. F. (O). 36 Rensselaer . . Troy, N. Y. DATE of DEATH. . Aug. 11, 1886. Dec. 9, 1889. . April 26, 1887. ... [Oct. 8, 1887. * * * * * * * * * * * * * > . Nov. 19, 1891. . |July 17, 1887. ... [Oct. 15, 1887. . Nov. 20, 1892. . Jan. 21, 1888. . Dec. 7, 1890. . April 30, 1886. . Dec. 13, 1887. ... [Oct. 31, 1886. . Jan. 5, 1890. . July 12, 1887. July 9, 1891. April 1892. . Jan. 13, 1887. . |April 12, 1891. . July 21, 1888. YEAR of MEDICAL College. GRAD- UATION. University of Pennsylvania 1835 University City of New York 1848 Bellevue Hospital Med. Coll. . 1876 Bellevue Hospital Med. Coll. . 1874 Bellevue Hospital Med. Coll. . 1872 University City of New York. 1850 University of Pennsylvania 1848 Fairfield Medical College 1836 Coll. Phys. and Surg., N. Y. . 1852 Buffalo Medical College . 1848 Geneva Med. Coll. . . 1851 Chenango County Med. Soc. 1843 } Geneva Med. Coll. . * 1861 Med. Dept. Univ. City of N. Y. 1862 Giessen and Marburg . . . . 1868 Med. Dept. Univ. City of N. Y. 1881 Coll. Phys. and Surg., N. Y. . 1829 University of Maryland . . 1835 Albany Medical College . 1884 Bellevue Hospital Med. Coll. . 1880 1859 1832 1884 1851 1836 1837 1850 1862 1851 1830 1848 1862 1848 1856 1876 1848 1860 1852 1846 1877 1854 1847 1857 1848 1886 1874 1864 1877 Moore, Joseph W. (F) Morrell, Isaac Pask, William (O). Peck, M. R. (O) Pollard, Abiathar . Pomeroy, Charles G. (F) Pryer, Wm. Chardavoyne (F) Purdy, Isaac (O) e Reynolds, Rufus C. (F). Ring, William (F). Robinson, Joseph W. * Rochester, Thomas F. (F) . Sabin, Robert Hall (F) . Sayre, Lewis Hall (F) Schoonmaker, E. J. (F). Skiff, George W. (O). Slack, Henry (F) . Slocum, J. O. (F) Smith, David M. Smith, Joseph T. (F) Smith, Marcellus R. (O) Sprague, William B. (F) Squire, Truman Hoffman . Steele, Charles G. . . . Steinführer, Gustavus A.(F.) Stevens, Frederick P. (O) . Stevenson, William G. . 47 79 55 62 90 '71 54 57 79 63 49 63 56 38 65 53 57 65 35 60 74 55 66 27 37 31 44 |Albany Chemung . Erie Warren Essex Wayne. Westchester Sullivan Monroe Erie Steuben Erie Albany New York Seneca . New York Dutchess . Onondaga . Yates Ontario Cortland Genesee Chemung . Erie New York Rockland . Schenectady . Troy, N. Y. Cornish, Maine ... [England . . . Sand Lake, N. Y. . |Bridgewater, Vt. ... [New York New York City Walkill, N. Y. * Columbia, Herkimer Co. United States Angelica, N. Y. . |Rochester, N. Y. . Saxton’s River, Vt. New York City Ulster Co., N.Y. . Pike, N.Y. Albany, N.Y. . Pompey, N. Y. New York City Farmington, N. Y. Taylor, N.Y. . Pavilion, N. Y. Russia, Herkimer Co. Buffalo, N.Y. . Germany Ithaca, N. Y. . Troy, Ohio . . Jan. Aug. 19, 1889. . Jan. ... [Dec. . Feb. . |Mar. Sept. 9, 1886. Sept. 8, 1887. Aug. 24, 1884. April 4, 1884. April 15, 1893. . Dec. 14, 1887. Sept. 24, 1888. Dec. 6, 1885. Dec. 22, 1886. . |April 20, 1887. . Jan. 4, 1887. . |May 24, 1887. Dec. 4, 1888. 2, 1890. 28, 1890. 10, 1886. 3, 1885. Dec. Mar. Mar. 9, 1890. Dec. 11, 1890. NOV. 12, 1888. July 2, 1890. Dec. 4, 1884. Feb. 3, 1888. 19, 1891. 16, 1891. 27, 1889. Castleton, Vt. . . . . Bowdoin Medical College . Med. Dept. Univ. Buffalo Albany Medical College Castleton, Vt. . . . . . Ontario County Med. Soc. . } Jefferson Medical College Coll. Phys. and Surg., N. Y. Castleton, Vt. . . . . . Fairfield Med. College, N. Y. University of Buffalo Buffalo Medical College University of Pennsylvania Albany Medical College Bellevue Hospital Med. Coll. Geneva Medical College Univ. City of New York . Albany Medical College Castleton, Vt. . . . . . Bellevue Hospital Med. Coll. Jefferson Med. Coll. Phila. Geneva Medical College University of Buffalo Coll. Phys. and Surg., N. Y. University of Buffalo Coll. Phys. and Surg., N. Y. Bellevue Hospital Med. Coll. Bellevue Hospital Med. Coll. DECEASED FELLOWS-Concluded. NAME. Sutton, George Samuel . Taylor, Isaac E. (F) . Van Dusen, Melville E. Vaughn, Frank O. (O) . Webb, Edwin (O) West, M. Calvin White, Francis W. Willis, A. B. . . . . Winship, Cornelius A. (O). Wood, Charles S. (F) * Woodruff, William D. (F) Young, Oscar H. (O) YEAR OF County. PLACE OF BIRTH. DATE of BIRTH. MEDICAL College. GRAD- UATION. Dutchess . . Louisville, N. Y. . Sept. 6, 1888. Coll. Phys. and Surg., N. Y. 1859 New York . |Philadelphia, Pa. . . Oct. 30, 1889. University of Pennsylvania 1834 Steuben . Wheeler, N. Y. . June 15, 1891. Med. Dept. Univ. Mich. . 1879 |Erie ... [Buffalo, N. Y. . . . [Mar. 18, 1891. Med. Dept. Buffalo Univ. iº 1880 Queens . Devonport, England . . Jan. 29, 1890. Coll. Phys. and Surg., N. Y. 1825 Oneida . . |Rome, N. Y. . . Oct. 20, 1891. Michigan University . . 1860 New York. . |New York City Oct. 9, 1889. Univ. City of New York . 1855 Schenectady . Coeymans, N. Y. . May 10, 1891. Albany Medical College 1870 Rensselaer Litchfield, Conn. Feb. 14, 1888. Albany Medical College . 1858 New York Litchfield, Conn. . Feb. 1, 1890. Jefferson Med. College, Phila. 1851 Suffolk . Portsmouth, Wa. . |Mar. 10, 1893. University of Pennsylvania 1855 Delaware . Pennsylvania Jan. 21, 1889. Jefferson Med. College, Phila. | 1876 IND EX Abdominal hysterectomy for my- oma, Dr. F. A. BALDWIN, 421. Address of welcome, Dr. J. G. TRUAx, 15. of the president, 18. Address on surgery, Dr. FREDERIC S. DENNIS, 201. Alcoholism, some personal observa- tions and reflections upon ; the effects of alcoholic abuse upon posterity ; and the treatment of alcoholism, Dr. H. E. SCHMID, 545. Alienist and the general practitioner, Dr. J. B. ANDREWS, 18. American surgery, achievements of, Dr. FREDERIC S. DENNIS, 201. ANDREWS, JUDSON B., president's address, 18. operations for epilepsy, 166. acute pleurisy, 273 examination and commitment of insane, 377, 378. cominitment of drunkards and morphinists, 558. Antiseptic injections in obstetrics, Dr. D. CoIVIN, 86. Appendicitis, chronic recurring, Dr. F. W. Ross, 740. Appendicitis, recent cases of, Dr. N. JACOBSON, 64 ARMSTRONG, S. T., should we treat fever ? 576. mitral stenosis in pregnancy, 386. AYRES, DOUGLAS, puerperal eclamp- sia, 98. paper jackets for lateral curva- ture, 715. BABCOCK, MYRON N., memoir of, 723. BALDWIN, FREDERICK A., abdom- inal hysterectomy, 421. Brain surgery, clinical contribu- ſº to, Dr. Roswell, PARK, Branch, First, officers for 1893, p. 4, report of, 737. Second, officers for 1893, p. 4, report of, 738. Third, officers for 1893, p. 4, report of, 740. Fourth, officers for 1893, p. 5, report of, 756. Fifth, officers for 1893, p. 6, report of, 758. BROOKS, L. J., examination and commitment of insane, 377. BROWN, CHARLES W., paraplegia, 130. BRYANT, JosLPH. D., treatment of fractures of the patella, 512. early extirpation of tumors, 185. BULL, C. S., tumors of the orbit, 105. CHACE, WILLIAM, memoir of, 736. Cholera, winter, in Poughkeepsie, Dr. JAMES G. PortEous, 521. CHRYSTIE, T. M. LUDLOW, muscu- lar traction for hip disease, 60. Climatology in its relation to dis- ease, Dr. S. J. MURRAY, 559. COLVIN, DARWIN, antiseptic injec- tions, 86. Committee of arrangements for 1891–92, 2. report of, 15, Coughing made easy in bronchiec- tasis, Dr. H. D. DIDAMA, 250. Council, annual report of the, 778. COUTANT, RICHARD B., memoir of . athaniel Clark Husted, M. D., 27. COWLEs, EDWARD, the mental symptoms of fatigue, 441. CRONYN, JOHN, operations for epi- lepsy, 166. , - acute pleurisy, 272. mitral stenosis in pregnancy, 386. abdominal hysterectomy for my- oma, 426. DAMAINVILLE, LUCIEN, memoir of, 725. Dºº, LDEN W., appendicitis, 7 puerperal eclampsia, 104. DENNIS, FREDERIC S., address on surgery, 201. 832 INDEX. erence to lesions of the brain Substance, DR. C H A R L E S PHELPs, 274. Histº F. W., acute pleurisy, mitral stenosis in pregnancy, 386. Orton prize essay—the control of scarlet fever, 746. HUBBELL, ALVIN A., extraction of Steel from the eye with electro- magnet, 427. HUSTED, NATHANIEL CLARK, me. moir of, 727. Identity of diphtheria, membranous Croup, and follicular tonsillitis, a study on the, Dr. E. G. DRAKE, 743. INGRAHAM, H. D., ectopic preg- nancy, 77 abdominal hysterectomy for my- Oma, 425. Insane, examination and commit- ment of the public, in New York city, Dr. MATTHEW D. FIELD, 365. Insane, the limit of responsibility in the, Dr. JoBIN SHRADY, 540. Insurance sponge, the, Dr. H. D. DIDAMA, 253. Intercranial lesion ; ante-mortem localisation; autopsy. Dr. J. G. ORTON, 753. Intestinal amastomosis, Dr. BEN- JAMIN M. RICKETTS, 187. JACOBSON, NATHAN, appendicitis, 64 JANvrin, J. E., cancer of the uterus, 92. ectopic pregnancy, 84. KAHLo, G. D., compound depressed fracture of skull, 189. Rings County Medical Association, annual report, 764. Lateral curvature of the spine, treatment of neglected cases of rotary, Dr. R. H. SAYRE, 687. List of Fellows registered at the ninth annual meeting, 10. of presidents, 7. e of delegates and invited guests, 14 Dermic and hypodermic therapeu- | tics, Dr. S. F. RogFRs, 676. DIDAMA, H. D., memoranda, prac- tical and suggestive, 245. acute pleurisy, 272. District Branches—see Branch. Diphtheria, membranous croup and follicular tonsillitis, identity of, Dr. E. G. DRAKE, 743. DOUGLAS, GEORGE, commitment of drunkards and morphinists, 558. DRAKE, E. G., identity of diph- theria, membranous croup and follicular tonsillitis, 743. DU BOIS, ABRAM, memoir of, 716. Electricity in midwifery, Dr. O. C. LUDLOW, 388. Eye, extraction of steel from, with electro-magnet, Dr. A. A. HUB- BELL, 427. Fatigue, the mental symptoms of, DR. EDWARD COWLEs, 441. FERGUSON, E. D., recent experience in renal surgery, 678. pneumotomy for abscess of lung, 38 treatment of rotary lateral curva- ture, 715. FERGUSON, JAMES, memoir of, 735. Fever, should we treat f Dr. S. T. ARMSTRONG, 576. FIELD, MATTHEW D., examination and commitment of the insane, 365. FLANDREAU, THOMAS M., memoir of M. Calvin West, M. D., 721. FLINT, AUSTIN, memoir of Lucien Damainville, M. D., 725. Fracture, compound, depressed, of skull, Dr. G. D. KAHLO, 189. Fractures of the patella treated by continuous extension ; patients not confined to bed, Dr. J. D. BRYANT, 512. Gastric ulcer, aetiology of, Dr. C. G. STOCKTON, 354. GOULD, GEORGE M., the mental symptoms of fatigue, 466. GoulBY, JoHN W. S., early extir- pation of tumors, 167. HANNAN, J. C., examination and commitment of insane, 378. Head, injuries of. A clinico-patho- logical study, with special ref- of Fellows by district and county, 783. of Fellows alphabetically, 806. of deceased Fellows, 826. INDEX. 833 of honorary Fellows, 824, of corresponding Fellows, 824. of non-resident Fellows, 824. of retired Fellows, 824. LUDLow, OGDEN C., electricity in midwifery, 388. pelvic version, 574. LUSIK, ZERA. J., mitral stenosis in pregnancy, 379. gastric ulcer, 364. MANLEY, THOMAS H., lesions of the ankle-joint, 39. MARTINE, G. R., memoir of James Ferguson, M. D., 735. Materia medica, pharmacy, and therapeutics of the year ending November 1, 1892, brief com- ments on, Dr. E. H. SQUIBB, 588. Maternal impressions, the question of, Dr. H. S. WILLIAMS, 135. MCGILLICUDDY, T. J., pelvic ver- Sion, 567. Membranous croup, diphtheria, and follicular tonsillitis, identity of, Dr. E. G. DRAKE, 743. Memoirs— MYRON N. BABcock, M. D., 723. WILLIAM CHACE, M. D., 736. LUCIEN DAMAINVILLE, M. D., 725. ABRAM DU BoIS, M. D., 716. JAMES FERGUSON, M. D., 735. NATHANIEL CLARK HUSTED, M. D., 727. M. CALVIN WEST, M. D., 721. Memoranda, practical and sugges- tive, Dr. H. D. DIDAMA, 245. Microbes, the rôle of in disease, Dr. N. B., SIZER, 405. Midwifery, the use of electricity in, Dr. O. C. LUDLow, 388. Mineral waters, crude and refined, Dr. H. D. DIDAMA, 248. Mitral stenosis in pregnancy, Dr. Z. J. LUSIK, 379. MOORE, E. M., injuries of the upper extremity, 469. lesions of the ankle-joint, 58. appendicitis, 75. ectopic pregnancy, 84, 85. th; ºnal Symptoms of fatigue, 68. MURRAY, S. J., climatology and disease, 559. Muscular traction for hip-joint dis- º Dr. T. M. L. CHRYSTIE, New York County Medical Associa- tion, annual report, 767. NORTH, NELSON. L., the commitment of drunkards and morphinists, 558. obº, M. C., pelvic version, 574. Officers and council for 1891–'92, 1. 1892–'93, 3. of the branch associations, 4. ORTON, J. G., an intercranial lesion ; ante-mortem localisa- tion ; autopsy, 753. Orton prize essay—the control of Scarlet fever, 746. Palliative treatment of cancer of the uterus and its adnexa, not amen- able to radical operative meas- ures, Dr. J. E. JANVRIN, 92. Paraplegia, Dr. CHARLEs W. BROWN, 130. PARK, ROSWELL, brain surgery, 146. PARSONS, FRANK S., acute pleurisy, 256 Patella, fractures of, treated by continuous extension ; patients not confined to bed, Dr. J. D. BRYANT, 512. Pelvic version, Dr. T. J. MCGILLI- CUDDY, 567. PHELPs, CHARLEs, injuries of the head, 274. early extirpation of tumors, 184. Pleurisy, acute, Dr. F. S. PARSONs, 256. Pleurisy, early aspiration in, Dr. H. D. DIDAMA, 245. Pneumotomy for tubercular abscess, Dr. J OHN B. WHITE, 30. PORTEOUS, JAMES G., winter cholera in Poughkeepsie, 521. Pregnancy, ectopic, Dr. H. D. IN- GRAHAM, 77. Pregnancy, mitral stenosis in, Dr. Z. J. LUSIR, 379, Poºngs, ninth annual meeting, 74. Puerperal eclampsia at the seventh month ; suggestions as to treat- ment, Dr. DOUGLAS AYRES, 99, PURPLE, SAMUEL S., memoir of Abram Du Bois, M. D., 716. PUTNAM, JAMES W., brain surgery, 165 the mental symptoms of fatigue, 834 INDEX. Quarantine, suggestions relating to improvement of, Dr. STEPHEN SMITH, 531. Renal surgery, some recent expe- rience in, Dr. E. D. FERGUSON, 678. REYNoLDs, T. B., memoir of Myron N. Babcock, M. D., 723. RICKETTS, BENJAMIN M., intestinal anastomosis, 187. RoGERs, H. C., typho-mania, 742. RogFRS, S. F., dermic and hypo- dermic therapeutics, 676. Ross, FRANK W., appendicitis, 74. brain surgery, 165. examination and commitment of the insane, 378. mitral stenosis in pregnancy, 385. abdominal hysterectomy for my- oma, 426. cº recurring appendicitis, 740. & SAYRE, REGINALD H., treatment of neglected cases of rotary lateral curvature, 687. Scarlet fever, the control of, Dr. F. H. HIGGINS, 746. SCHMID, H. ERNST, and posterity, 545. SCHRADY, JoHN, responsibility in the insane, 540. SIZER, NELSON B., microbes in dis- ease, 405. acute pleurisy, 273. Skull, compound depressed fracture of, Dr. G. D. KAHLO, 189. SMITH, SPEPHEN, improvement of quarantine, 531. alcoholism SQUIBB, E. H., materia medica, pharmacy and therapeutics for 1892, 588. Steel, extraction of from the eye with the electro-magnet, Dr. A. A. HuBBELL, 427. STOCKTON, CHARLES G., gastric ul- cer, 354. STRONG, THOMAs D., memoir of William Chace, M. D., 736. Traumatic osteo-arthritic lesions of the ankle-joint, Dr. THOMAS H. MANLEY, 39. TRUAx, JoHN G., address of wel- come, 15. pneumotomy for abscess of lung, 38 abdominal hysterectomy for my- oma, 426. Tumors, a plea for the early extir- pation of, Dr. JoHN W. S. Goul, EY, 167. Tumors of the orbit. Nineteen cases illustrating a previous paper, Dr. C. S. BULL, 105. Typºmania, Dr. H. C. RogFRS, 742. Upper extremity, a review of some ºries of, Dr. E. M. MooRE, 69. WEST, M. CALVIN, memoir of, 721. WHITE, JoHN B., pneumotomy for abscess of lung, 30. WILLIAMS, H. S., maternal impres- sions, 135. paraplegia, 134. th: ºnal symptoms of fatigue, 67. MAN 2 3 1917 ſ UNIVERSITY OF |||ſiliſiiiii 3 9015 07477,6785 a- s . ſae ;&% ſae tºgae ºº!!!