Contents: no. 1. de Gimbernat, Antonio. A new method of operating for the femoral hernia, transl. from the Spanish... 1795. No. 2. Garnett, T. Outlines of a No. 8. Pearsm, George. course of lectures on chemistry. An inquiry emcerning the history of the One pox,.. 10798. M. 4. Woodville, William Reports of a series of invculations for the variolae vaccinal, or cno pox. 1799. A A No.1. New Method of Operating FOR THE FEMORAL HERNIA, TRANSLATED FROM THE SPANISH OF de DON ANTONIO DE GIMBERNAT,. m SURGEON TO THE KING OF SPAIN. WITH PLATES. TO WHICH ARE ADDED By the TRANSLATOR, QUERIES RESPECTING A SAFER METHOD OF PERFORMING INOCULATION; AND THE TREATMENT OF CERTAIN FEVERS. 55A SOCIETY OF THE COUNTY AC OF DEMY OF MEDICINE OF BROOKLY MEDICA AND LONDON: 80175 LIBRARY Printed for J. JOHNSON, St. Paul's Church-Yard. M,DCC,XCV. KINGS Taubman/Rare Gook Room RD 621 G553 il 70%, 2 fold pl, 8 Hernia - Femoral ADVERTISEMENT. THE fuperiority of Mr. Gimbernat's method of operating for the femoral or cru- ral hernia will not, I believe, be contested. The difference, indeed, appears to me to be exactly this; the patient who is treated ac- cording to Mr. Gimbernat's method will infallibly recover; whereas former modes of operating are well known to have been attended with the utmost danger. This was a fufficient motive for under- taking to tranflate the following tract. I wish my tranflation may raife fome curiofity in our furgeons with regard to the publica- tions of their brethren abroad. English- men in general are difpofed to undervalue the productions of foreigners; and among Jurgeons this propenfity has, I think, been lately [ i ] lately ftrengthened by the example of one ignorant man of fuperior genius. What I have added, I give as mere con- jecture; fhould perfons who have the op- portunity think my conjectures worth put- ting to trial, fome useful knowledge may poffibly be acquired, Had I myself had any fufficient opportunity of trying what I have propofed on the fubject of the fmall- pox, 1 fhould not have offered my obferva- tions to the public in their prefent crude State. T. B. Clifton, June 26, 1795 AN ACCOUNT OF FORMER METHODS OF OPERATING FOR THE CRURAL HERNIA, AND OF THE INCONVENIENCES WITH WHICH THEY WERE ATTENDED. OF F all complaints the true hernia is doubtlefs the most frequent. On careful calculation it has been found that one eighth part of the human fpecies is afflicted with it. (Arnaud in bis preface p. 100.) The majority of infants become ruptured; and many are born fo. Some of thofe that are * This, it muſt be remembered, was written in Spain, where the pernicious practice of fwaddling and tight cloathing is not yet exploded.-T. B cured [ 2 ] cured in infancy, (as almoft all will be if properly treated) relapfe, if not in the prime of life, at leaft in old age, when original hernias are extremely com- mon. The number of thofe that die of this complaint is not inconfiderable, and moft of thoſe who have ruptures, are incapable of performing certain functions of great importance to the ftate; and they gene- rally lead a precarious and valetudinary life. This accident having at all times been fo common and dangerous, it is difficult to fay, why the treatment of it fhould have remained fo long in the hands of perfons without education, and with- out the ſmalleſt acquaintance either with the human body, or the diforder they attempted to remedy. It is only in the prefent century, that well-informed prac- titioners have applied themfelves to this defpifed part of furgery; hence the abo- minable herd of Gelders and Rupture Doc- RANU tors [ 3 ] tors has infenfibly disappeared; and fur- geons have acquired diftinguished honor by the difcovery of various new fpecies of hernia, and of fafe methods of curing them radically. Thefe improvements are entitled to our warmeft approbation. It muft never- theleſs be acknowledged, that this branch of furgery has by no means attained the defirable degree of perfection. The prin- cipal defect lies in the mode of operation, and practitioners are ftill embarraffed to operate with fafety in cafes of the crural or femoral hernia, which prefents fome of the most dangerous cafes. Some, after the herniary fack is opened, advife to cut the fallopian ligament across and forwards; others to cut it outwards, or inwards. Mr. Arnaud, to avoid the danger of thofe methods, invented a blunt hook or curved levator, with which he made an affiftant raiſe the ligament fo as to dilate it, till there was room to return B 2 the [4] the inteftine into the abdomen; a method which may have much affifted Mr. Leblanc in the invention of his famous dilator, though he himself affures us, that he borrowed the hint from Lecat's method of gradually dilating the neck of the bladder in the operation for the ftone. The method invented by Leblanc in 1750, and fince eſtabliſhed by much prac- tice, is doubtless preferable to all others in the inguinal hernia; at firft view it appears fo alfo in the crural hernia. When the ftructure however of the parts concerned in the crural hernia is carefully compared with Leblanc's method, it will be clearly feen that his dilator is not to be recommended. In the inguinal, the aperture which affords paffage to the protruded parts, is formed by two aponeu- rotic bands, equally dilatable and having parallel fibres: fo that were it not for an expanfion of the fafcia lata which unites firmly [ 5 ] firmly with the bands, and ftrengthens their junction, they would feparate on the application of the flighteft force, as far as the fpine of the ilium. This difpofition without doubt induced Mr. Leblanc to fuppofe, as others have fuppofed, that the extremity, which he calls the handle of the ring, (l'anfe de l'anneau,) re- fembles in ſhape the handles of baskets, and that it confifts of fibres, going off from the bands themfelves and forming fpirals round the handle. Hence they have compared this difpofition of parts with that which they fuppofed to exiſt in the foramen of the diaphragm that gives paffage to the vena cava. Anato- mifts however, who have well examined thefe apertures, know that there is not the fmalleft refemblance between them and the rim of a basket. If therefore the dilator of Leblanc be introduced into the inguinal ring, in fuch a manner that when B 3 its [6] its fides are opened, they apply to the bands of the ring, the one will be parted from the other, more or lefs, according to their rigidity and to the force exerted; and in the fame proportion will be ſtretch- ed the fibres of the fafcia lata that traverſe the handle of the ring, whence a dilatation of the ring will inevitably refult. But in the crural hernia, the aperture through which the parts iffue is not formed by two bands, but it is a foramen almoft round, proceeding from the inter- nal margin of the crural arch near its infertion in the branch of the os pubis, between this bone and the iliac vein: fo that in this hernia, the branch of the os pubis is fituated more internally than the inteftine and a little behind; the vein ex- ternally and behind; and the internal border of the arch before. Now it is this border which always forms the ftrangula- tion, and this is the only part contributing to [ 7 ] to form the foramen, that can be extend- ed without danger to the patient; the vein cannot; it might eafily be ruptured; whence would arife an hæmorrhage, that would probably foon terminate with life. In cafe of ftrangulation it would be very dangerous to introduce into this foramen the dilator of Leblanc, on account of the preffure that must be made, on opening it, upon the great iliac veffels, notwithſtand- ing the aponeurotic feptum dividing the foramen from the paffage for thofe veffels; neither could this inftrument at all extend the internal margin of the arch, becauſe it will be cloſe to its infertion, and alfo becauſe all its force is applied, not to its edge as would be neceffary to its extenfion, but along it, fince Leblanc always opens it with the canal of the gorget towards the inteftine: in no other pofition indeed could it be opened, without facrificing the ftrangulated inteftine. B 4 I fhall [ 8 ] I fhall be told perhaps, that Leblanc with his dilator raifes the inteftine a little upwards. But who does not perceive that this elevation is infufficient; befides, the inftrument is very unfit for this pur- pofe; to which it may be added, that if the edge or border, that produces the ftrangulation, were not prevented by its tenfion from being elevated fufficiently, the tenaculum of Arnaud would then be preferable. I will venture to affert, that in the cafes of crural hernia, in which the dilator of Leblanc has been employed, fortunately for the patient, it never was introduced into the foramen; for the foramen was unknown, as alfo the dupli- cature of the crural arch that forms it. Hence Leblanc believed that the fallopian ligament, and cellular fubftance below, formed the ftrangulation of the inteftine. (vide his Operations of Surgery, T.11, p. 141. Paris, 1782.) "The fimple anato- "mical [ 9 ] "mical defcription," fays he, "of the " crural arch, beneath which pafs the 66 parts that form the crural hernia, "fhews that the dilatation may be effec- "ted there, ftill more eafily than in the in- 66 guinal ring. This arch is principally "formed by a ligamentous and aponeu- "rotic band, which is ftretched between "the anterior fuperior fpine of the ilium " and the fpine of the os pubis, in which "it is inferted, becoming narrower to " its infertion: it is called the fallopian or inguinal ligament: beneath it is "cellular fubftance of confiderable width, " which may be preffed fideways by the flighteft force. There are not, as "in the ring, any collateral fibres "which ftrengthen the aperture, 66 66 through which pafs the parts that "form this hernia, hence this paffage is 66 more eafy. If we lift a little the nar- "roweft part of this band, with the "" round [ 10 ] "round part of the dilator, and make a "little preffure on the fides, the aperture " will be opened fufficiently to allow the difplaced parts to re-enter, as experi- ence has fhewn. 66 "Experience and theory concur to " evince, that the dilatation propofed is "juft as poffible in the crural as in the " inguinal hernia; and although Mr. "Arnaud confiders the operation for the " latter as much more difficult and dan- 66 gerous; obfervation has convinced me, "that according to my method, it does "not retain this character." Such an im- perfect defcription of the crural arch be- trays the want of anatomical knowledge of this part: and from the defcription it- felf we may deduce the inutility of the dilator of Leblanc, in the laft mentioned operation; for he himself confeffes that if the fallopian ligament be raiſed a little, and flight lateral preffure be made on the cellular [ 11 ] II cellular texture below, the parts may be eafily replaced. Can there be a ftronger proof, that the dilator of Leblanc has never been introduced, in operations for the crural hernia, into the foramen, where the ftrangulation takes place? I am per- fectly perfuaded, that in all fuch cafes, after the herniary fack has been opened, the parts could have been introduced by the hand alone; fo that the introduction ought not to be attributed to the dila- tor. Leblanc fell into a great miftake, in fuppofing that the cellular texture, and fallopian ligament, form the ftrangula- tion. That he entertained this opinion, appears from his being content with raif- ing the fallopian ligament a little, and making a flight preffure on the cellular fubftance of the fides, parts which never occafion the ftrangulation; for this al- ways depends on the inner edge of the crural [ 12 ] crural arch, of which Leblanc had no knowledge. Leblanc was alfo miftaken in fuppo- fing that the gradual dilatation was more eafily effected there, than in the inguinal ring, and in afferting in confequence, that the operation for the crural hernia was not more difficult, or dangerous, accord- ing to his method, than for the inguinal. Is it not evident from this, that Leblanc was unacquainted with the ftructure of the crural arch, and with the part that forms the ftrangulation? From what I have faid, it follows that all the methods hitherto propofed, are either unneceffary, as that of Leblanc, (in which there is alfo great danger if the dilator be introduced, as was intended, into the foramen of ftrangulation) or elfe attended with great riik, as the best practitioners confefs; fince, if the fallopian ligament be cut acrofs, the pofterior pillar of the inguinal ring [ 13 ] ring is deftroyed without remedy in both fexes, and in the male an important artery will always be cut. This has been clearly fhewn by Ar- naud, who relates that, in confequence of a difpute on this point, an experiment was made in the Hotel Dieu, at Paris, in prefence of three able anatomifts, Ver- dier, Ruffel, and Baffeul. The firft fubject they choſe had a ftrangulated crural her- nia, ftill fubfifting, of which the patient had died. On this fubject Mr. Baudou, firft furgeon to the hofpital, performed the operation in prefence of the reft, with as much caution and dexterity as it is per- formed on the living fubject. He cut the fallopian ligament acrofs and forwards, and eafily reduced the rupture. Mr. Ruffel, who could not believe that the fperma- tic artery would be divided in this me- thod, diffected the part with the utmoſt care, and found the artery really divided. That [ 14 ] That he might not be obliged to give up his opinion, he imputed this to fome ac- cident; he was, however, foon unde- ceived, when he repeated the operation in the fame way on the other fide of the fubject. He found, notwithstanding the precaution with which he operated, that the fpermatic artery was equally divided, though he performed the diffection with his own hand. This artery, when di- vided within the abdomen, occafions an hæmorrhage very difficult to ftop; and even when we fucceed in ftopping it, the miſchief in regard to the propagation of the fpecies fhould be confidered, if the vas deferens be divided, as is frequently the cafe. Laftly, the patient is more than ever liable to relapfes, becauſe when the pof- terior pillar of the inguinal ring is cut, this forms with the crural ring a common aperture, large enough to give paffage to a con- [ 15 ] a confiderable portion of inteftine; the confequence therefore is a much larger hernia than before the operation, as ac- tually happened to a woman on whom Mr. Arnaud operated in this way in 1727. He was profecuted in confe- quence; and he himself confeffes that if the judges had not been very intelligent, he muft have been caft in damages and cofts. Cutting the fallopian ligament oblique- ly outwards, endangers ftill more the life of the patient, for the epigaftric artery will be infallibly divided at its origin. An hæmorrhage extremely difficult, or ra- ther impoffible to ftop, will be produced, yet no external figns of it will be ſeen, and the patient will die in a few minutes, to the furpriſe of the operator, till the cauſe of the unfufpected death, and at the fame time the imperfection of this method, be detected by diffection. If the fallo- pian [ 16 ] pian ligament, as fome have propofed, be cut obliquely inwards, the epigaftric ar- tery will be equally divided, though a little farther from its origin. The risk is the fame; the only difference is that the death of the patient is not quite fo immedi- ate, and the chance of tying the artery is fomewhat greater. Moreover, in all theſe methods the fallopian is cut, which is perfectly uſeleſs, unless the incifion be carried on to the internal edge of the cru- ral arch. Arnaud, with a view to avoid all theſe dangers, invented, as I have mentioned, a blunt tenaculum, which I remember Dr. Hunter fhewed to fome of his pupils, and of which he spoke in his lectures with fmall recommendation. This tenaculum can only raiſe the external edge of the crural arch; it is not however, this, but the internal edge, which forms the ftran- gulation and the inftruments in queftion 2 can [ 17 ] can never reach the internal edge. We may therefore prefume that in all the cafes where Arnaud ufed his tenaculum, the reduction might have been effected by the hand alone after opening the her- niary fack. All practitioners have acknowledged the danger of this operation, although fome writers very flightly obferve by the by, that it is to be performed as for the inguinal hernia, an erroneous and moft dangerous direction, which may be found in Garangeot and Sharp. Arnaud, Pott, and Bertrandi, however, exprefsly avow the difficulty and rifk attending all the methods propofed to their time, and without venturing to decide which de- ferves the preference, they only recom- mend extreme caution to the operator. Dr. Hunter did the fame in 1777, when 'I attended his lectures, without determin- C ing [ 18 ] ing any thing as to the merit of the re- fpective methods. Laftly, Mr. Bell has fpoken of the operation in the following terms. 66 "The membrana adipofa, tendinous. expanfion of the fafcia lata, and her- "nial fack, being all cautiously divided, "if the protruded parts are found in a "fituation proper for reduction, we "fhould immediately attempt to replace "them; and as the fpace below the li- "gament through which they have paf- "fed is confiderable, this may frequent- ly be done without dividing the liga- "ment, merely by preffure properly ap- 66 plied with the hand, while the pa- "tient's body is placed in the pofture we "have already directed in the bubono- "cele, as being beft fuited for favour- *ing a return of the bowels. "When in this manner the contents " of the tumor can be reduced without "the [ 19 ] "the neceffity of dividing the ligament, "the patient is thereby faved from a "great deal of hazard, as from the par- "ticular fituation of the fpermatic vef- "fels, and epigastric artery, with refpect " to this ligament, any cut made into the "fubftance of the latter runs a very 66 great risk of dividing one or other of "them. * "The fpermatic veffels, as they go " along to pafs out at the opening in the external oblique mufcle, run nearly 66 upon the very edge or border of Pou- part's ligament, almoft through its "whole length, fo that I confider it as 66 impoffible to make a free divifion of "the ligament without cutting them "acrofs.† * The fpermatic veffels run more than an inch along the canal formed by the duplicature of the crural arch, be- fore they pafs out at the inguinal ring, and in this courfe they are joined by the vas deferens. G. + The experiment in the Hotel Dieu is a proof of the utter impoffibility of doing this. G. C 2 << We [ 20 ] "We have been adviſed indeed by "fome, in order to avoid wounding the "fpermatic veffels, which they acknow- << ledge would certainly happen if the "incifion fhould be carried directly up- "wards, to cut in an oblique direction "outwards. In this method they allow "that the epigaftric artery, from the "courfe it ufually takes, may very pro- 66 66 bably be divided. But the risk attend- ing the divifion of that artery they do "not confider as of much importance; " and if the diſcharge of blood, occa- "fioned by any wound that may be "made in it, fhould happen to be con- "fiderable, they fpeak of it as a very (6 eafy matter to take it up with a needle "and ligature, and needles of various fhapes have been invented for this pur- "pofe. Even in emaciated people, " however, it is a matter of much dif- ficulty to reach the epigastric artery, " and 66 [ 21 ] "and in corpulent patients it will be "found altogether impoffible to furround "it with a ligature; fo that the younger "6 part of the profeffion ought to be very "cautious in receiving the directions ufually given upon this fubject. "On reading the remarks of the late "Mr. Sharp upon this point, to fe- 66 66 cure the epigaſtric artery by means of a ligature, one would expect to be the "eafieft of all operations; but the dif- "ficulty which in reality attends it is ઃઃ fuch, as muft convince every one who " has tried it, that Mr. Sharp himfelf "had never put it in practice. 66 "But even, although this accident of wounding the epigaftric artery could "be guarded againft in the moft eafy " and effectual manner, yet I will ven- ec ture to fay, when a femoral hernia is "of any confiderable fize, the diftention "of the ligament thereby produced muft C 3 SO ACADEM MEDICAL AND UNTY OF MEDICINE OF 66 bring KLYN KINGS LIBRARY [ 22 ] 66 bring the fpermatic veffels fo nearly on "a line with the under border of the 66 46 ligament, as to render it altogether im- poffible to divide the one without the "other; and whoever will examine "theſe parts in the ftate we have now "defcribed, will fee that this cannot be "avoided, whether the incifion be car- "ried directly upwards, or even oblique- "ly outwards or inwards. "Some authors, from being fenfible of "the danger attending this part of the operation, have propofed merely to di- "late the paffage, inftead of dividing the 66 ligament; and Mr. Arnaud, a French "writer on this fubject, delineates a curved "levator for the purpofe of fupporting the 66 ligament till the protruded parts are re- "duced. But as we are to fuppofe in every cafe of ftrangulated hernia, that "the paffage through which the parts "have fallen down, is already dilated to nearly [ 23 ] Ce nearly its utmoft poffible extent; in "fuch a fituation to attempt a farther " dilatation without the affiftance of the "knife, would feldom, it is probable, "be productive of any advantage. "A confiderable time ago it occurred "to me, that in this part of the opera- "tion fome affiftance might be derived "from performing it in the following 66 manner, and having fince had occafion " to make trial of it in one cafe where "it anſwered moft effectually, I can now therefore recommend it with fome "certainty. Instead of dividing the 66 ligament in the ordinary way, I only "made an incifion into part of its thick- "nefs. In order to protect the parts " below, I first infinuated the fore-finger " of my left hand * between the gut and * An evident proof that the fallopian ligament, or ex- ternal border of the crural arch, does not occafion the ftrangulation, as all writers have hitherto fuppofed. G. C4 "the [ 24 ] "the ligament; and then with a com- CC mon fcalpel made a cut of about an " inch in length, beginning above, and 66 proceeding to the under border of the "ligament. 66 "The firft fcratch with the fcalpel was very flight; but by repeated "touches it was made to penetrate al- "moft through the whole thickneſs of "the ligament, till at laft a very thin "lamella only of it remained. The 66 finger being now withdrawn, the pro- "truded parts were returned with great "eafe, the ligament at its weakened part, 66 ", yielding gradually as the neceffary pref- "fure was applied for the reduction of "the inteftines. "As in this manner the opening "may be enlarged to any neceffary ex- "tent, and as the fpermatic veffels, and 66 epigaftric artery, are thus effectually "avoided, the operation for this fpecies " of [ 25 ] "of hernia may not only be done with equal certainty, but with the fame de- 66 gree of fafety as for any other kind of rupture. For by not penetrating with "the fcalpel through the whole thick- "nefs of the ligament, under which thefe "blood-veffels lie; they are thereby 66 * kept free from all kind of danger du- "ring this part of the operation; and "the preffure to be afterwards ufed for "the reduction of the protruded parts, "if done in an eafy, gradual manner, as "it ought always to be, can never in- "jure them materially; as blood-veffels " of the fize and ftrength of which theſe are eafily admit of a degree of exten- "fion, much more confiderable than can "be here required." 66 This author was perfectly well ac- quainted with the danger of dividing the * The crural veffels, not the fpermatic and epigastric, lie below the ligament, as will be feen in the fequel. G. fallopian [ 26 ] fallopian ligament in any direction what- ever, and with the difficulty of dilatation without incifion. He was not, however, well acquainted with the duplicature of the crural arch, or with its attachment along the creft of the os pubis; neither had he any exact acquaintance with the foramen, which gives paffage to the parts forming the crural hernia; confequently he could ill underftand what part forms the ftrangulation. Had he known it, he would not have meddled with the fal- lopian ligament, not even with its edge, as he did, doubtlefs fuppofing, that this ligament forms the ftrangulation. This able practitioner nevertheleſs dif- covered a method of operating without dividing the fpermatic or epigaftric veffels. He introduced his finger below the fal- lopian ligament, between this ligament and the inteftine; an evident proof that there was no ftrangulation there: he then made [ 27 ] made a very fuperficial incifion from above downwards into the thickeft part of the ligament to its lower edge; and with- out cutting quite through it, he continued his incifion about an inch. He would naturally reft the back of the fcalpel upon his finger, which ferved as a guide to the inftrument, and at the fame time, as a defence to the inteftine. The inci- fion being continued for an inch, the operator would inevitably cut the internal edge of the crural arch. Now cutting this but for a few lines, gives fufficient room for the eafy reduction of the parts, and there is no neceffity to touch the ligament, as it never occafions the ftrangu- lation: Confidering the place and direction in which the internal edge is divided, we fhall perceive that the epigaftric veffels are much expofed in both fexes, and the fpermatic veffels and vas deferens in the male. [ 28 ] male. I am perfuaded, that an hand lefs dexterous and lefs in practice than Mr. Bell's, could not have avoided dividing them; and as there is left only a thin lamina between the edge of the inftru- ment and the veffels above mentioned, I will venture to affirm, that he will not be equally fuccefsful in all the cafes in which he fhall follow this method. Al- though, therefore, the internal edge of the crural arch will be cut, I would earneſtly diffuade from this mode of operating, on account of the imminent danger attend- ing it. Evidence in favour of the Author's method. I ſhould not propofe my new method with fo much confidence, if I had not in its favour the fuccefsful event of two cafes, in which I practifed it in Barcelona in 1772 and 1773- My patients were female. I regret that my travels have prevented [ 29 ] prevented me from accumulating more facts. Profeffor Torner, however, of Bar- celona, who was prefent at both my operations, has communicated to me two other cafes, in which he followed the fame method. One of his patients was a male, aged 54. The operation was per- formed on the 5th of June 1786, and by the 16th of the next month, compleat recovery had taken place. The other was a nun 68 years of age; the operation was performed on the 23d of Auguft 1788, and the patient was well by the 4th of October. Both theſe perfons are ſtill living. The nun has not been troubled with any hernia fince, though the has worn no trufs. The man wanted no- thing of this kind for a twelvemonth; he then met with a violent accident, and had an hernia in the fame place. Befides thefe four fuccefsful cafes, I am encou- raged to make my method public, by the decided [ 30 ] decided approbation it received from Dr. Hunter, to whom I explained it on a preparation in 1777. As it is, in my opinion, free from all the dangers that have been pointed out, and perfectly eafy to practice, I cannot but flatter my- felf, that every furgeon who puts it to trial, will find it preferable to any hi- therto propofed. Its fafety and fuccefs entirely depend- ing on a perfect knowledge of the part where the accident takes place, I am under the neceffity of premifing an ex- act defcription of the crural arch. This part, although it is fo remark- able, had been little examined, and lefs underſtood by anatomifts, till I demon- ftrated it for the first time in 1768. The ignorance of its true ftructure has occa- fioned fuch a variety of dangerous me- thods; and this is in reality, the reafon why furgery has not made the fmalleft progress 2 [ 31 ] progrefs in the treatment of this acci- dent. Defeription of the Crural Arch. In the lower part of the abdomen, the external oblique mufcle forms a ſtrong and broad aponeurofis. The fibres are parallel; they defcend obliquely from without inwards; and the lower extend from the fuperior anterior fpine of the ilium, to the os pubis, at a little dif- tance from which they open into two bands, or pillars, to form the inguinal ring. In all this tract, the aponeurofis forms a duplicature inwards. This du- plicature, which is more manifeft towards the os pubis, conftitutes a ſtrong whitish cord, which Fallopius fuppofed to be a ligament; and fo it was called, till of late, when it received the name of crural arch, becaufe at the top of the thigh, it has fome diftant refemblance to an arch or vault. This aponeurotic dupli- [ 32 ] duplicature in its infide forms a canal, which is larger towards the os pubis, and lodges the fpermatic veffels. Thefe vef- fels run for a certain fpace through the canal, before they traverfe the inguinal ring, where the canal terminates. Between the ilium and os pubis, the arch is kept fufficiently tenfe by an ex- panfion of the fafcia lata, which unites intimately with it in its whole length, in fuch a manner, that if the expanſion be cut, the arch is confiderably relaxed. In the natural ftate, the tendons of the pfoas and iliac muſcles pafs beneath it, as alfo the great crural veffels, and the lympha- tic coming from the lower extremity. In the difeafed ftate, fome of the parts contained in the abdomen alfo país, and form a tumor at the lower part of the groin. This is what is called a crural hernia. This [ 33 ] This arch offers to our confideration fome peculiar contrivances, little or not at all underſtood, though the knowledge be abfolutely neceffary to a perfect idea of the crural hernia, and to the fafe opera- tion for its cure. When the inferior band feparates from the fuperior to form the inguinal ring, it goes to infert itself in a tubercle of the os pubis, which has been denominated its fpine, and which gives origin to the creft of the fuperior branch of this bone, and is a continuation of the linea ileo-pectinea; moreover this pillar is not only inferted into the fpine by a confidera- ble union of aponeurotical fibres, but the duplicature of the arch being much greater there, it is continued inwards along the creft of the pubis, by means of a re- markable plait or duplicature, confifting of a portion of the aponeurofis. The par- ticular difpofition of this duplicature, ex- tending from below upwards, and its infer- D tion [34] tion from the ſpine to the end of the creft, which makes more than an inch in fome fubjects, is highly worthy of our confide- ration; for without it, we fhould all proba- bly fuffer large and dangerous protrufions of the contents of the abdomen. In con- fequence of this ftructure, the crural arch has two edges; one external, rounded like a cord, thicker towards the pubis, and re- fembling a ligament, as Fallopius actually denominated it; to this adheres the ex- panfion of the fafcia lata: in emaciated perfons, the direction and tenfion of this cord may be felt through the integu- ments. The other edge, which I have cal- led internal, is the termination of the edge of the aponeurofis; it is very thin, and from its origin unites intimately with the aponeurofis that covers the iliac mufcle. This ftrict union, and that of the fafcia lata with the external edge, are moft perceptible from the anterior fupe- rior 1 35 ] rior fpine of the ilium to the neighbour- hood of the crural veffels; hence the crural arch is more flattened and fixed down in all this courfe on the iliac muſcle, ferving it as a band to keep it in its place during its contractions; confequently it is impof- fible that a crural hernia can ever take place in this tract, as fome have fup- pofed. As foon as this intertexture of aponeu- rofis reaches the great fecondary external iliac artery, there is detached from the internal edge of the crural arch a mem- branous expanfion (which is ftrengthened by the tendon of the fmall pfoas muf- cle, when this mufcle exifts,) and in- finuates itſelf behind the great fecondary external iliac artery and vein. This ex- panfion goes to be inferted cloſe to the ex- ternal edge of the pectineus mufcle: more- over, one lamina from it paffes over that mufcle, and is attached to the creft of the D 2 [ 36 ] the branch of the os pubis, where it is united with the duplicature of the arch which terminates in the fame creft. By this union is formed a fpecies of ligament which paffes along the creft, below which the fuperior extremity of the pectineus mufcle is inferted. From this divifion of the crural arch there arifes an aponeurotic fheath at the top of the thigh; it begins at the crural arch itſelf, clofe to the os pubis; fo that the expanfion, which has been defcribed as fent from the internal edge of the arch, and paffing behind the iliac veffels, forms the pofterior part of the fheath, while the anterior is formed by the exter- nal edge of the fafcia lata. The iliac veffels, enveloped in the cellu- lar fubftance of the peritonæum, enter into this fheath in their paffage out of the abdo- men; there are likewife fome glands and lymphatics in it; but the crural nerve always [ 37 ] always paffes without the fheath towards its external and pofterior part. The iliac artery and vein, before they enter into the fheath, fend off the epi- gaftric veffels by its anterior part: theſe veffels "pafs obliquely inwards, between the crural arch and fpermatic veffels, which they appear to embrace on their entrance into the canal of the arch. From the external lateral parts of the iliac vef- fels, after their entrance into the fheath, are fent off the fmall inferior iliac branches, which take their courfe to- wards the fpine of the ilium, clofe to the infertion of the oblique internal and tranf- verfe muſcles, in the bottom of the dupli- cature of the crural arch. In the internal lateral parts of the fheath cloſe to the branch of the os pubis, precifely where the infertion of the dupli- cature of the arch ends, and on the infide of the great fecondary iliac vein, there is D 3 left [ 38 ] left a foramen fufficiently diftinct, almoſt round, at which many lymphatics enter. A lymphatic gland is fometimes fitted into this foramen, and the parts which form the crural hernia always pafs through it, confequently we may properly call it the crural ring. A fingle gland placed in this ring would prevent the iffue of the parts contained in the abdomen; but if a portion of the inteftine fhould flide be- hind, fo as to get out of the cavity, it would be very difficult to diftinguish the hernia at firft. A furgeon not acquainted with the ftructure would be much embar- raffed if he were to attempt the opera- tion. The great iliac veffels occupy the prin- cipal portion of the orifice of the ſheath; the fpermatic veffels clofe a little of the external fide before they enter the canal of the arch. The epigaftric veffels, in their way to the mufculus rectus, cover it fuffi- ciently [ 39 ] ciently in its anterior and internal part. Laftly, fome aponeurotic fibres turn in from the internal edge of the arch; and a few lymphatic glands affift in ftop- ping it compleatly, fo that it is very diffi- cult for the parts contained in the abdo- men to make their way out, except through the crural ring. If the particular ftructure of the crural arch and its tenfion as kept up by the ex- panfion of the fafcia lata be confidered, we fhall clearly fee the reafon why the crural feldom obtains fo great a bulk as the inguinal hernia. We fhall likewife fee why the tumor is regularly round, hard, and flippery; a circumftance that caufes much heſitation and even miſtakes in practitioners of fmall experience. We fhall alſo perceive why the operation is more dangerous, and reduction without operation more difficult. This difficulty has laid practitioners of the greateft credit D 4 under [ 40 ] under the neceffity of performing an ope- ration which they dreaded, becauſe they did not know how to fteer befide the dan- gers that threatened the patient's life. To underſtand the preceding defcription ful- ly, fee the two plates at the end of this tract. Before I proceed to explain the new method of operating without danger, it will be proper to remark that the fymp- toms of ftrangulation are the fame in this hernia as in others, and that they are to be mitigated by the fame means Thefe means belong rather to a compleat treatife on hernias than to the prefent differtation. Nevertheleſs as the reduction ought to be repeatedly attempted before the opera- tion is refolved upon, I fhall lay down a few ufeful rules for effecting the reduc- tion by the hand alone: from my expe- rience and the particular ftructure of the parts, [ 4 ] parts, I think that this fhould not be at- temped in the fame manner as in other cafes of hernia. Method of Reduction without Operation. The patient ſhould be laid on the fide oppofite the hernia, with his body a little bent and fomewhat lower than the pelvis; the head fhould be inclined to- wards the breaft; the thigh on which the hernia is fhould be in a ftate of half flexion, ſo as not to be at all in the way of the operator. The operator fhould ftand clofe by the bed, on the fame fide with the hernia: with the hand next the pa- tient's abdomen, he fhould grafp the tumor at its bafe and upper part, and compreffing it moderately on the fide by his three foremoſt fingers, he fhould, at the fame time, with the other hand puſh the lower end of the tumor upwards and inwards, to direct it towards the crural ring, [ 42 ] ring, for it cannot poffibly be re- duced by any other means. This at- tempt ought to be continued for a long time without intermiffion, provided the tumor is not inflamed; the force, in cafe it be neceffary, fhould be gradually increaſed. But when the patient is fa- tigued, the compreffion and puſhing fhould be difcontinued, without lofing hold of the tumor; which, on the con- trary, fhould be firmly grafped, until the patient is refreſhed and the reduction can be attempted anew. I have fometimes found above an hour neceffary to effect this purpofe; and I have reafon to believe that I have been more fuccefsful than others, who, without attending to the above rules, have contented themſelves with a flight attempt at reduction, for fear of injuring the inteftine. I can aver, that of numerous ruptures which I have treated in this manner, there have [ 43 ] have been very few which I have not been able to reduce; and among theſe are fome which have baffled other prac- titioners; in none of theſe cafes has any bad confequence followed. For although the compreffion and pufhing have been long continued, and great force has fome- times been applied, it has always been gradually increafed. The operator's nails put the patient to great inconvenience if he does not keep them cut cloſe.. I ought to add, that this method will be very in- jurious, if the tumor be inflamed and confiderably painful; and it will be ftill worfe, if the violence of the fymptoms announce inflammation in the inteftine. In thefe circumftances the judicious prac- titioner will not harrafs the patient with ineffectual and perhaps fatal attempts at reduction by the hand, but will proceed directly to the operation. Method [ 44 ] Method of Operating. The patient being placed as for the operation of the inguinal hernia, and the hernial fac being properly laid open, an attempt fhould be made, if the inteftine be uninjured, to replace it by the hand. For this purpofe a little more of the in- teftine fhould be drawn out, becauſe fome- times the incarcerated portion is fo ftrong- ly contracted as not to allow paffage to the matter contained in the part beyond. This is frequently the only impediment to reduction: it is generally to be overcome by bringing to the ring, if poffible, a portion of the inteftine that has remained in the abdomen. This not having fuffer- ed ftrangulation, will not be contracted like that which has fuffered it for hours and days. If the reduction cannot be effected in this way, it is abfolutely neceffary to di- vide [ 45 ] vide the part that occafions the ftrangula- tions. For this purpofe introduce, along the internal fide of the inteftine, a canu- lated or grooved found, with a blunt end and a channel of fufficient depth. This is to be directed obliquely inwards, till it enter the crural ring, which will be known by the increaſed refiftance; as alfo when its point refts upon the branch of the os pubis. Then fufpend the intro- duction; and keeping the found (with your left hand, if you are operating on the right fide, and v. v.) firmly refting upon the branch of the os pubis, fo that its back fhall be turned towards the in- teſtine and its canal to the fymphyfis pubis, introduce gently with your other hand in- to the groove of the found a biftoury with a narrow blade and blunt end, till it enter the ring: its entry will be known as be- fore by a little increaſe of refiftance. Cautiously prefs the biftoury to the end of 2 the [ 46 ] the canal: and employing your two hands at once, carry both inftruments clofe along the branch to the body of the pubis, drawing them out at the fame time. By this eafy operation you will divide the internal edge of the crural arch at its extremity; and within four or five lines of its duplicature, the remainder continuing firmly attached by the inferior band or pillar, of which it is the continuation. This fimple incifion be- ing thus made without the fmalleft danger, the internal border of the arch, which forms the ftrangulation, will be confider- ably relaxed, and the parts will be reduced with the greateſt eafe. By this new method, the operation for the crural hernia, which the moſt cele- brated furgeons have juftly accounted ex- tremely dangerous, is rendered the moft fimple and fafe of all that are practifed in cafes of ftrangulated hernia. The [ 47 ] The fallopian ligament is not at all concerned in this operation; neither can the fpermatic cord or fpermatic artery, much lefs the epigaftric, be divided, for all theſe parts are left at the fhoulders of the found, and far remote from the edge of the biftoury. The fame may be faid of the obturatrix artery, when it arifes from the great fecondary external iliac, though it paffes over the branch of the pubis in its way to the foramen obturator. If by chance any of its fmall branches extend to the duplicature, they are fo very minute that they carry with them no danger. I may fay the fame of ano- ther fmall anomalous artery, that occa- fionally ramifies through this part, fince capillary veffels are never obftacles to ope- rations of furgery. The danger moft to be dreaded, is that of wounding the urinary bladder, which would certainly be expofed, if it were full [ 48 ] full at the time of operation; but it can- not poffibly be wounded if empty. The precaution, therefore, of making the pa- tient evacuate his urine a little before the operation, which was obferved by Garan- geot in fuch cafes, muft by no means be neglected. In pregnancy of four months and up- wards, the uterus may alfo be wounded. To avoid this injury, a biftoury, blunt at the end, is to be employed, like that which Arnaud ufed in the bubonocele. Befides, we must take care not to intro- duce it far, and to have the patient greatly inclined to the oppofite fide. After the operation, a fimple dreffing is to be uſed; no extraneous body fhould be introduced into the incifion; on the contrary, care fhould be taken to bring the lips together, and to keep them fo by means of fome ftrips of adhefive plaifter. Over this dry future let a fimple com- prefs [ 49 ] Upon prefs be laid, flightly covered with an ointment made of white wax and good common oil, that it may not ftick to the ftrips of plaifter, or the lips of the wound. This comprefs fhould extend two inches beyond the future, to prevent the introduction of air, or any body ca- pable of occafioning irritation. the comprefs lay fome lint, which ſhould be kept in its place by other compreffes, and a fimple fupporting bandage like the inguinal, which is commonly fufficient, or by the fimple fpica, if neceffary. The patient is to be kept in the fame pofition, as after the operation for the inguinal her- nia; and he is to maintain equal quiet- nefs, and to obferve the fame diet. The firft dreffing, if nothing new occurs, is to be left on five or fix days at leaft. Another is to be applied exactly like the former, and to be continued as long as poffible; the dry future is to be employed, (unless E [ 50 ] (unless another become abfolutely necef- fary) in order to procure a ſpeedy union. Should any thing unufual occur, the mode of treatment will of courſe be va- ried according to the circumftances. 742 EXPLA- ( 51 ) EXPLANATION of the PLATES. PLATE I, fhews the pelvis vertically divided through its middle, with the two loweft lumbar vertebræ, one of the nates, and a portion of the thigh with its integuments. The interior part of this right half of the pelvis is fhewn for greater dif- tinctnefs. 1. The inferior ramus, or branch, of the os pubis. 2. The tefticle. 3. Section of the corpus cavernofum. 4. Superior ramus, or branch, of the os pubis. 5. The fymphyfis pubis. 6. The duplicature of the crural arch, and its in- ſertion in the creft of the os pubis. 7. The crural ring formed by this duplicature. 8. The epigaftric veffels. 9. Part of the rectus muſcle. 10. Aponeurofis of the abdominal mufcles. II. The vas deferens. 12. The fpermatic veffels, enveloped in cellular fubftance. 13. Great fecondary iliac vein. 14. Great fecondary iliac artery. 15. Crural arch at its origin. 16. Section of the abdominal muſcles. 17. The iliacus muſcle. 18. The creft of the iliums 19. The primary iliac artery on the left fide., 20. The primary iliac vein. 21. The fecondary internal iliac, or the epigastric artery. [ 52 ] PLATE II. The fame fide of the pelvis after the MO operation. 1. Superior branch of the os pubis. 2. Incifion in the duplicature of the crural arch cloſe to the creft of the os pubis, by which the crural ring is widened, and the internal margin of the arch is relaxed confiderably. 3. Section of the abdominal mufcles. 4. The epigaftric veffels. 5. The crural arch. 6. The vas deferens. 7. The fpermatic veffels. 8. The fecondary iliac artery. 9. The fecondary iliac vein. 10. Section of the primary iliac artery. QUERIES QUERIES CONCERNING INOCULATION. BY THE sift of galgheed TRANSLATO R. A N opinion relative to the beft me- thod of performing inoculation, of which it is of great importance to afcer- tain the validity, has been lately advanced by Dr. George Fordyce. (See Tranfac- tions of a Society for the Improvement of Medical and Chirugical Knowledge. John- fon, 1793). According to Dr. Fordyce, the moſt effential circumftance in this operation, is to make a puncture exceed- ingly fmall, and fo fuperficial that if no blood be drawn, the better. This direc- E3 tion [ 54 ] tion is founded upon the fuppofition that the lefs matter is applied, the more mild will be the diſeaſe. The evidence offered by the author in favour of this opinion, is nearly as fol- lows. He inoculated three young ladies belonging to the fame family, by three punctures each. One puncture fuppurated before the two others, in one of theſe cafes; in the two other cafes, the three punctures fuppurated together. In thefe laft, the difeafe was much more fevere. Happening to inoculate a child with five punctures, he remarked that the diforder was very unfavourable. From theſe facts combined with the fuppofition, that when infection has taken place the fubfequent application of matter has no effect, he de- duced the opinion above. The author adds, that he has fince inoculated a great number of perfons by a very fmall punc- ture, and that he has not met with "one cafe [ 55 ] cafe in the ſmalleſt degree unfavourable." It might have been better perhaps, if Dr. Fordyce had affigned the number of pa- tients on whom inoculation had been thus performed. From the well-known experiments of Spallanzani, on artificial fecundation, it had occurred to me, that if it were advan- tageous to introduce a fmall quantity of variolous matter at the time of inocula- tion, this might be done by diluting the matter with water; nor did it appear pro- bable that its power of communicating the fmall-pox would be deftroyed, even by a confiderable quantity of water. The paper of Dr. Fordyce revived this idea, and I communicated it to various practitioners, particularly of furgery, whom I had occafion to meet. I found two who had actually adopted the practice of dilution; and both have obligingly per- mitted E 4 [ 56 ] mitted me to communicate the refult of their experience to the public. As to sdman, sdi bongile had soybe Letter from Mr. WATTE, Surgeon, at Calne, in Wiltshire.moneq To etnemhogye at recibe SIR, wond-flow or mor Calne, May 26, 1795- 2014 I had the honour of receiving your let- ter of the 22d inft. and will faithfully anfwer your queries refpecting the dilu- tion of variolous matter, to the best of my obfervation. About three years ago, I was defired to inoculate fome patients in a neighbouring village; I had only a fmall quantity of moift matter upon a bit of horn. When I arrived, I found about thirty people expecting to be inoculated, and fearing there might not be a fuffi- ciency of fluid matter, I procured fome cold water, and mixing it well with the flat fide of the lancet upon the horn, ino- culated [ 57 ] culated them all. They went through the difeafe fo regularly and favourably, that it ftruck me that the diforder might be rendered milder by this method. An opportunity has fince offered in our town to follow the fame practice, viz. in Sep- tember, 1793, when the poor of the parish were inoculated. I procured the matter from a woman at Bradford, near- ly a goofe-quill full. This matter being very vifcid, was diluted, and divided be- tween myſelf and two other gentlemen, who affifted in inoculating the poor. We inoculated fix hundred and upwards, without any preparation; the diluted gave the diforder with the fame certainty as pure matter; and all the patients re- covered: a few had pretty full crops not- withstanding. Befides the poor, I ino- culated about two hundred patients, who all recovered, except one child about five months old: this child had a red fcor- butic [ 58 ] butic humour all over it, but as it could not eſcape the diſorder in the natural way, it was inoculated. When feized with the eruptive fever, it had a convulfion fit, after which petechia appeared, and it died before the eruption was complete. So that you will pleaſe to obferve, that of eight hundred patients treated by this method, all recovered except this child. Now in inoculating a whole parifh, we have no choice of patients, all ages, and the fickly as well as others, were inocu- lated; but theſe were moftly children, as I affifted in inoculating the whole parish, about twelve or thirteen years ago. In anſwer to the particular heads of your enquiry. First, average degree of dilution? Equal parts of water and mat- ter, fometimes a greater proportion of water. Secondly, number inoculated in this manner? At least eight hundred. Thirdly, deaths? One child of five months [ 59 J ] months old. Fourthly, comparative mild- nefs? The patients went through the dif eafe without any irregular, or dangerous fymptoms; generally a few diftinct puf- tules appeared, which maturated kindly; not more than five or fix out of the whole number had pretty full crops, but thoſe were diftinct. Fifthly, my own obferva- tions? I have fometimes known trouble- fome abfceffes form in the axilla, after inoculation, but I do not recollect one fuch inftance after this practice, or any ill con- fequence to the health of the patients fince; fo that I cannot help thinking but the diforder may be rendered milder and lefs fatal by it. I am, Sir, With great efteem, &c. ALLEN WAYTE. To Dr. BEDDOES. Letter [ 60 ] Letter from Mr. ROLPH, Surgeon, at Thornbury, in Gloucestershire.s DEAR SIR, sicAgreeably to your requeft, I fend you a ftatement of fome facts, which have occurred in the courfe of my practice, from the uſe of diluted variolous mat- ter. In the year 1793, I was called to ino- culate feveral perfons: two of the num- ber had a confluent difeafe, and died; and fome others had it in a violent degree. In thefe inftances, recent matter was uſed.t From theſe unfortunate cafes, I was led to conceive, that by a confiderable di- lution of the matter, the violence of the difeafe might be alleviated. I was not ignorant of the received opinion on this point, but convinced how very erroneous many received opinions are, I was deter- mined [ 6 ] mined to put this to the teft of experi- ment. In the month of March, 1794, an op- portunity offered itfelf. I was called to vifit J. Price, who at that time was fickening of the fmall-pox, and on whom the eruption was juft beginning to make its appearance. To prevent the conta- gion from fpreading, the parish officers had Price removed to the houfe of a poor perfon, who, together with two children, was inoculated. The lancet I had by me was armed with variolous matter, taken in a very early ftage of the com- plaint; this I largely diluted in a little warm water; when, on Sunday, 23d, (the day Price was removed) I proceeded to inoculation, making only one flight fcratch through the fcarf fkin of each perfon. On Tuesday, 25th, there was no ap- pearance of infection; I therefore inocu- lated [ 62 ] lated them a fecond time, with the fame lancet, and in a fimilar mode. Thurf- day, 27th, about noon there was no in- flammation. Apprehenfive now, of their receiving the difeafe in the natural way, I took fome matter from Price, and again inoculated them, but in the other arm. The Sunday morning immediately follow- ing, the children having taken a purging medicine, complained of flight fickness, and in the evening of that day, the puf- tules made their appearance, few in num- ber, and unaccompanied by fever: in the ufual time they came to maturity. I must not conceal, that the parts to which the undiluted matter had been ap- plied were inflamed a little, the day after its infertion, which appearance continued to increaſe in a ſmall degree, but no un- eafinefs was felt in the axilla at any time. Is it likely that the undiluted matter, applied on Thurſday at noon, fhould produce [ 63 ] produce an eruption the Sunday follow- ing? Or is it probable that two perfons ſhould take the difeafe in the natural way at the fame time, and that the eruption in each fhould make its appearance in feven days, after expofure to contagion ? Though there was not the leaft inflamma- tion from the firft, or fecond inoculation, yet every circumftance confidered, I am induced to attribute the diſeaſe to the firft. It may not be unneceffary to ob- ferve, that no perfon in the neighbour- hood was then labouring under the dif- eafe, or had been for fome time before. Price caught it whilft out on a journey. The man and children had not been in the This queftion will, I fuppofe, be generally anfwered in the negative. In Dr. Haygarth's Sketch, there is a ta- ble, from which it appears, that out of eight hundred and thirty-three patients, inoculated at Newcaftle and in Lon- don, not one had any commencement of the eruptive fever before the fifth day. T. B. [ 64 ] the way of contagion, till the day of ino- culation. I have fince availed myfelf of every con- venient opportunity of communicating the complaint in a fimilar mode; par- ticularly to three of my own children and one fervant; two of my children and the fervant had no eruption or fever, and but a flight inflammation in the arm; my other child had a mild difeafe; but neither of them had the leaft uneafinefs in the axilla. The advantages of this mode of inocu- lation have been realized in fo many other inftances, as not to permit me to afcribe it wholly to accident. Wherefore, I am led to conclude, that the more the matter is diluted, provided it remains in fuf- ficient force to produce infection, the better. Should any objection be made to this mode of practice, it muft arife from the uncertainty of the infection taking place in a given time. This ob- jection [ 63 ] jection, I think, except under particu- lar circumſtances, can be of little confe- quence. I have hitherto purpofely omitted faying any thing of the man I inoculated, becauſe I have to obferve, he never received the in- fection, though repeatedly inoculated with undiluted matter, and for days expofed to contagion, living in the fame room with Price, who died of the difeafe. It is worthy of remark, that this man had fome years before a complaint in- cident to cows, and commonly called the Cow Pox; a malady more unpleaſant than dangerous. It is generally received by contact in milking. In the human Species, the complaint is fometimes local; at other times abforption takes place, and the glands in the courfe of the abforbents become indurated and painful. When this is the cafe, I have learned from my own obfervation and the teftimony of fome old practitioners, that fufceptibility to the fmall F [ 64 ] fmall-pox is deftroyed. Some advantage may probably in time be derived from this fact. I remain yours, June 10, 1795. To Dr. BEDDOES. With great refpect, T. ROLPH. It is pretty generally agreed, that in- fants, before the time of teething, ought by no means to be inoculated. Dr. For- dyce, in the paper already quoted, ob- ferves, that, "Of the children who have "died in London of inoculation for "many years, as far as I have been able "to collect, more than two thirds have "been under nine months." The want of that firm connection between the trains of motion, which is eftabliſhed by habit, is I imagine a much more general caufe of mortality among inoculated in- fants than the fymptoms arifing from the protrufion of the teeth; they may and ought [ 65 ] ought to be mitigated by freely lancing the gums. In fome fituations, however, inocula- tion of infants will be preferred as the fmaller evil; and in fuch emergencies, a method of performing the operation fo as to produce a milder difeafe, is of un- fpeakable importance. For the reafons already adduced, I propofe a trial of the following method. I have two objects in view: 1. To enfure the application of a fmall quantity of diluted matter; and 2, to enfure a fuperficial wound. Should more ample experience fhew neither of thefe circumftances to influence the de- gree of feverity of the difeafe, there will not, I fuppofe, be any advantage in the method to compenfate the fmall addi- tional trouble it will occafion. 1. Apply a blifter of an extremely fmall fize, not more than a very fmall fraction of an inch in diameter, over the infertion of the deltoid mfucle. After the fearf kin F 2 bas [ 66 ] has rifen and all pain has fubfided, open the vefication, and let out the liquid. 2. Mix fome variolous matter with ten or twenty times its bulk of water; dip the point of a camel's hair pencil into the di- luted matter, and touch the expofed fkin as lightly as you can. Space and quantity must be determin- ed by experience. From the analogy of fome other animal fluids, it is probable that the addition of feveral hundred times its bulk of water would not deſtroy the power of the variolous matter. I have mentioned the ufual place, but it is poffible that this may not be the moft advantageous for the application of the matter. To fome perfons, the pain arifing from the blifter may occur as an objection; but they will be perfons who have never witneffed the feverity of the inoculated fmall-pox in young infants, and the anxiety and injury to the health of the mother thence arifing. Query [ 67 ] Query concerning Fever. From a fingular, if not an unexam- pled concurrence of teftimony from va- rious quarters of the world, we learn that the ufe of quickfilver has been attended by the moft beneficial effects in certain cafes of fever. According to accounts publiſhed by Dr. Clark, Dr. Wade, Mr. Boag, Dr. Rufh, and Dr. Chisholm, this treatment has been far more fuccefsful than any other of which we have infor- mation. Medical men, who believe that in fevers of a certain kind, and particularly of fuch a violence or malignity as thofe which fell under the care of the authors above mentioned, there occurs a putrid diffolution of the blood, will revolt at the idea of fuch practice. But the greater number of pyhficians feem at preſent to be perfuaded that the term putrid was former- ly uſed at random in medical reaſonings; and [ 68 ] and why in fact ſhould fetid perfpiration or urine be regarded as the fign of a putrid ftate of the blood, any more than offen- five breath? Such however is the baneful operation of falfe theory, that it produces an im- preffion even on the minds of thoſe who reject it. Hence we fhall not yield our affent to the fame evidence in behalf of quickfilver, as would produce full convic- tion with regard to the power of any other drug, that had never been fuppofed to increaſe the fuppofed putrefaction of the fluids. Quickfilver would probably be of effen- tial utility in many fevers, common in this country; and yet one cannot expect that it fhould foon have the trial to which it feems fairly entitled. We fhall perhaps moft fpeedily obtain the advantage it may afford, and prevent the facrifice of many victims to prejudice, if we take pains to inveſtigate the principle on which it ope- 2 rates. [ 69 ] rates. Its operation in fyphilis has been much the fubject of difpute. By fome it has been fuppofed to deftroy the fyphilitic virus, exifting in the body. Enquirers, more on their guard against first appear- ances and hafty conclufions, believe that quickfilver ftimulates to a new mode of action, and fo fuperfedes the effect of the contagious matter. May not its be- neficial effect in fevers depend upon a principle different from either of theſe? Since in fevers the fyftem continually paffes from a ftate of torpor to a ſtate of excitement, may not the increaſed action of the falivary glands tend to keep the whole body in a more equable ftate, and prevent the formation of fever-fits? Sa- livation is ftated to be effential to the cure; and if future obfervation ſhould eſtabliſh the fact, will not my fuppofition be confirmed? Will falivation prevent the return of the fits of intermittents? To [ 70 ] To evince the propriety of attending to new information on the fubject of fever no laborious inveftigation is requifite. Simple infpection of the bills of mortali- ty is fufficient. I do not expect that any perfon, acquainted with the uncertain effi- cacy of the other methods that have been hitherto recommended, will deny that the treatment by quickfilver is entitled to the moſt mature confideration. The object in cafes of fever being to excite fpeedy falivation, does not Mr. Clare's way of applying quickfilver pro- mife to be the most advantageous? In hydrocephalus internus, quickfilver is never, I believe, of fervice, unleſs fali- vation be brought on. At the period when phyficians are often called in, this is a thing very difficult to be accomplish- ed. Ought not therefore the fame me- thod of applying quickfilver to be tried in this diſeaſe? THE END. 16 15 14 13 22 11 17 18 Pl.1. 19 10 20 9 27 8 7 5 درم 3 TY OF THE COUNTY ACADEMY OF MEDICINE OF MED AND LIBRARY OF BROOKLYN KINGS 2 33 5 8 9 10 Pl.2. 3ne