P, 1,403, 534 A it iſ E M A N A C E M E N T of T H E Ordinary Heart Cases sº T H E T R E A T M E N T O F º Pulmonary Tuberculosis D I A G N O S I S. A. N. D. T. R. E. A. T M E N T O F * Typhoid Fever º B Y C T H O O D M D . Formerly Professor of Physiology, American College of Dental Surgery; Lecturer on Electro-Therapeutics; Professor of Mental and Nervous Diseases; Professor of Principles and Practice of Clinical Medicine and Diseases of the Heart in Chicago Homeopathic Medical College; Attending Physician Cook County Hospital 2.959 W A SHING TO N B O U L E V A. R. D. c Hºc A G O L L No is THE MANAGEMENT OF THE ORDINARY HEART - CASES. In reading the United States vital statistics, one is astonished at the great increase in the number of deaths from organic disease of the heart. Strange as it may seem, the greater increase is in the farming and rural districts. When we stop to con- sider that it is the general practitioner who has the care of these cases in their beginning and for the greater part, if not all the time of their illness, we believe that a discussion of the management of such cases will be of general interest. Doctors are but little, if any, different in their lives from men and women in other walks of life. We all get into habits more or less. In the hurry and rush of our general work, we are prone to become more and more routine. And while we know that the physician is less inclined to be routine than his brothers in other walks of life, yet we feel that, to a large extent, all cases of organic heart disease look alike to the general prac- titioner. - If we can bring out in this paper, or its discussion, a few points that will tend to increase and encourage the study of such cases individually, our aim has been ac- complished. - Believing as we do that in order to understand or. ganic heart disease we must not only have a fairly good anatomical knowledge of the heart as well as a fairly good physiological knowledge of its action, but we must 3 also have a fairly good knowledge of the pathology of heart diseases as well as a knowledge of the pathological conditions producing changes in the heart muscle, its valves or their appendices. We therefore beg your in- dulgence while we recapitulate some of the salient patho- logical facts to be remembered. First, diseases of the heart are structural, valvular and functional. Func- tional conditions we shall not consider at this time. Dis- eases of the valves are usually called organic heart dis- eases and very often, after a diagnosis of the valvular condition has been made, no further study is given to the case. - Primary disease of the valves of the heart is confined to the left side. A few cases of congenital valvular disease of the right side are found. The result of an intro uterine endocarditis and are not to be discussed at this time. The order of frequency of valvular lesions of the left side of the heart are: first, mitral regurgitation; second, aortic regurgitation; third, mitrel stenosis; fourth, aortic stenosis. In order to study these conditions in- telligently, we must ascertain first, the valve or valves affected; second, how badly diseased; third, the condi- tion of the heart muscle; fourth, the state of the general nutrition. Diagnosis. It is not our intention to discuss at any length the diagnosis or the diagnostic points of valvular lesions. You all have, more or less, the ability to correctly diag- nose such conditions. We shall, however, briefly review some of the important points. First, the location of the murmur; second, the direction in which it travels; third, its time—whether systolic, presystolic, diastolic, pre- diastolic or late systolic or diastolic—; fourth, the pres- 4 ence of cardiac hypertrophy and of what portion of the heart as indicated by the position of the apex and the cardiac dullness. Heart murmurs are described in various ways—loud, soft, blowing, harsh, musical, etc.;-but the more impor- tant ones are the loud and soft sounds. A loud murmur may be good or bad. It may be good at one time and bad at another. A soft murmur may be good or bad. As a rule, a loud murmur means less than a soft murmur. When a murmur that has been loud and distinct becomes soft it means beginning or ruptured compensation. When a murmur that has been soft and blowing in character in the course of an acute illness of any kind becomes harsh it indicates additional valvular involvement. When the heart sound is distinctly heard with the mur- mur, the lesion is slight. When the murmur replaces the heart sound, the lesion is severe. The study of the pulmonic second sound is of vital importance in forming a correct conclusion of an organic heart disease. In youth and up to 29 years of age, the pulmonic second is more distinct than the aortic second. From 29 years of age to 45 or 50, the pulmonic second and the aortic second become more and more equal. The pulmonic second is most distinct during the first half of this period and the aortic most distinct during the latter half of that time. If one is to train his ear to the proper appreciation of the value of the pulmonic second sound, he must take every opportunity of com- paring it with the aortic second in cases where no cardiac lesion exists. It will be remembered that the pulmonic second sound in health is caused by the recoil of the blood in the pulmonary veins and that the aortic second is caused by the recoil of blood in the aorta, supple- mented by the contraction of the muscular coats of the 5 aorta. Therefore, any accentuation of the pulmonic second sound means increased pressure in the pulmonary circulation. * In valvular lesion the pulmonic second sound shows first, the amount of obstruction to the pulmonary cir- culation, caused by the mitral disease; second, the con- dition of the right ventricle. If a mitral disease exists and the pulmonic second is distinct, it means some lesion of the valve and hyper- trophy of the right ventricle. If the pulmonic second has been distinct and begins to lose its snap, it means loss of tone of the right ventricle. As the greater number of organic heart diseases are lesions of the mitral valve, let us at this time consider these conditions and their management. In the course of an acute illness—such as rheumatism, chorea, pneumonia, typhoid fever, etc.—the pulse should begin to be out of proportion to the temperature, soft and of low tension, some slight cough be present with slight dyspnoea, on lying down. The indications are endocarditis to a greater or less extent. A murmur may or may not be heard. The treatment is first, for the acute condition present; second, general nutritional treatment; third, absolute rest in bed until the pulse is normal, no dyspnoea is present and the pulmonic second sound has assumed its normal tone, or until compensa- tion has taken place, if a mitral lesion has occurred. But, while all cases of mitral lesion—the result of endo- carditis—have such a beginning but few are recognized and by far the greater number of the cases have become chronic when the doctor sees them. . When a mitral lesion has been recognized, there are two questions to be answered. First, is it a chronic lesion the result of a pre-existing endocarditis? Second, 6 is it due to dilation of the mitral orifice or a rela- tive lesion? If the patient has known for some time that he has an organic heart disease, or if there is a history of rheumatism or other acute condition, fol- lowed by a period of dyspnoena and cough with a gradual improvement, it would assist in concluding that the case is a valvular lesion; but if the apex is well to the left of the nipple line and down in the sixth Space, or under the sixth rib, and the pulmonic second sound is accentu- ated, you may be sure it is a chronic lesion. But if the case is from 55 to 70 years old and there is no history of an endocarditis, the apex is only a little to the left of the normal line, the pulse is weak, soft and irregular and the history of the dyspnoea is recent, you may con- clude that the case is one of chronic myocarditis—the result of degenerative changes in the heart muscle. If the apex is to the right of the nipple line or in the nipple line in the sixth or seventh space the impulse heaving in character the pulse water hammered, the mitral lesion is relative secondary to aortic regurgitation whether you hear a diastolic murmur or not. If the case is a chronic valvular lesion, the first ques- tion to solve is in what stage is it? Is it in the stage of compensation or is compensation partly or altogether broken? If the pulse is fairly full of fair volume, fairly regular, there is no cough or dyspnoea—except on ex- traordinary exertion—the pulmonic second is distinct and no edema of the feet or ankles exist, you may say that compensation is good. The next question to answer is what is the extent of the lesion? Or how badly is the heart crippled? If the murmur is well defined and the first sound of the heart as heard at the apex, not replaced by the murmur, and the apex is only a little to the left of the nipple line and 7 the pulmonic second is litle accentuated, no dyspoena is present and the pulse fair, the lesion is slight. If the murmur is soft and blowing in character and wholly, or to a great part, replaces the first sound at the apex, and the apex is well to the left of the nipple line or even in or beyond the axillary line, the pulmonic second dis- tinctly snappy, the lesion is a severe one. If the murmur is soft, the pulse small and irregular, the finger nails, and often the fingers, blue and cold, the apex impulse tappy, and the second sound at the apex lost and dyspnoea present on slight exertion, the case is one of combined regurgitation and mitral stenosis, whether the presystolic murmur or roll of the stenosis is heard or not. It is to be borne in mind that it is not the amount of hypertrophy present that means perfect compensation, but how well is the normal standing of the circulation being maintained. As a rule, a great amount of hyper- trophy means a severe lesion and a small amount a lesion of less extent and gravity. The management of this particular class of cases is first, forbidding overtaxing of the heart. His watchword is “Go slow. Take things easy.” Avoid excesses of all kinds. Look after the digestion and bowels, regular habits of life. Such cases should be impressed with the importance of reporting to their medical adviser every so often where the condi- tion of pulse, heart’s action and pulmonic second, is to be noted. If the patient is complaining of cough, in- ability to lie down and dyspnoea on exertion with or without edema of the feet and legs and scanty urine, compensation is ruptured to a greater or less degree and the questions to answer are: first, what is the extent of the lesion? Second, what is the condition of the heart muscle? In estimating the extent of the lesion, it must be distinctly determined whether the mitral lesion is regurgitation alone, stenosis alone or a combination of 8 the two. The diagnostic points for stenosis, and regur- gitation combined have been pointed out—if the hands are blue and cold, the pulse small, irregular and weak, the apex not so far to the left, the apex impulse tappy and the aortic second Sound absent at the apex and no mitral murmur present—the case is one of mitral stenosis whether the presystolic murmur or roll is heard or not. If the pulse is of fair volume, but of low tension and irregular, apex well over or in the axillary line, the apex impulse inclined to be wavy under the hand with now and then a distinct impulse and the murmur is soft and blowing and not heard so well far away from the mitral area and the pulmonic second is not at all accentuated, the heart has dilated to considerable extent. If there is edema of the feet and legs, it has dilated enough to stretch the right auriculoventricular opening. The correct management of such a case is of vital im- portance to the future of that heart. Usually the first thing done is to give some heart tonic or stimulant which very often only increases the dilation, when we remember that the dyspnoea, cough, scanty urine, edema of the feet and legs is due to venous engorgement. Is it better to take the whip to the lagging horse or to first lighten his load? We cannot relieve the pulmonary venous engorge- ment without bleeding, but we can the systemic by re- lieving the overloaded liver and bowels—1 to 1% grains of calomel in broken doses, followed by some saline. Then one every hour until 5 or 6-1/6 grain podophyllin granules have been given, will empty the liver and bowels and often stimulate the kidneys and do wonders for the dyspnoea and pulse when it is combined with absolute rest in the semi-prone position. Now, we may give some heart tonic. Arcenicum Alb, arcenicum iode, strophan- thus, spartine, giving 2 or 3-1/6 podophyllin granules each day enough to keep the liver well emptied with light, 9 easily digested food. After a few days, chelidonia may be stubstituted for the podophyllin. If the heart does not respond to these tonics, then the alkaloid caffein may be used. If these remedies do not bring relief from the dyspnoea, edema, irregular pulse, etc., digitalis should be tried. But the writer is convinced that more harm has been done from the use of this drug than good, that it is one of the best, if not the best, heart tonic we have, he believes. But it acts upon the muscle of the heart, producing increased muscular activity. It also acts upon the muscular coats of the aorta and arterial system, pro- ducing contraction of the arteries. Therefore, the blood pressure is raised and the work, required by the heart, is increased. To whip up such a heart that is more or less dilated is dangerous. True, if the heart muscle will stand it, the results are all that can be expected. But the liver and bowels must be relieved first and the reme. dies, spoken of, tried. Then digitalis may be given, watching its effects care- fully and remembering that it requires 24 hours to ob- tain the full physiological effect of digitalis and that, after this time, it continues to act for 24 to 36 hours. In using digitalis we believe one should learn to rely upon one or two preparations and know how to get the best results from them, often failure is due to too small a dose, at other times from too long intervals between doses. If digitalis is used in this class of cases, the fat free, preparation may be given in from 5 to 8 drop doses every 2 to 4 hours. If, after 24 to 36 hours, the urine has increased some in amount, the pulse has slowed down to an extent and the cough and dyspnoea are re- lieved even a little bit, then the drug may be continued and the dose increased to from 8 to 10 drops. If the improvement continues, the dose may be lessened or held, as the case requires. 10 If you are convinced that you have a case of mitral regurgitation and mitral stenosis, it is a grave question whether digitalis ought ever to be used. If it is, it should be in small doses and under careful watching; and on the first symptoms of a thready pulse, or any in- crease in the dyspnoea, it should be stopped. If the . feet and legs are edematous and the abdomen more or less dropsical, the urine very scanty, the pulse small, soft and irregular, the impulse wavy in character, the murmur soft or almost inaudible, the pulmonic second indistinct, the cough and dyspnoea severe, the heart has dilated and compensation is ruptured. It is one of the marvels of the experience of the physician to see the improvement that follows careful and scientific treat- ment of such apparently desperate cases. The manage- ment is first, absolute rest, not in bed until the symptoms are relieved, but in a morris chair or some such chair; second, relief of the hypatic and abdominal venous en- gorgement as much as possible and our experience has been that it is wonderful what can be done, the active principle of eleaterium in 1/20 grain doses every hour until free catharsis occurs; then 2 to 4 doses each day, enough to be given to produce 2 or 3 good, full watery movements in the 24 hours. The medi- cation for the heart requires great care. We are sure that we have obtained the best re- sults by giving these cases strychnine, 1/60, 1/40 or 1/30 of a grain to a dose combined with nitro glycerine; 1/250 to 1/150 of a grain every 2 to 6 hours, with a fair amount of Rhein or Tokay wine or whiskey. Alcohol is not in any sense a heart remedy. It acts upon the vaso motor nerves, dilating the perferal arterials, thus relieving the work on the heart. The nitroglycerine acts in the same way while the strychnine stimulates the heart through the pneumo-gastric. After the pulse has 11 become somewhat more regular, the impulse Iess wavy and the dyspnoea relieved even a little, then some heart tonic may be given—strophanthus 2 to 4 tincture tablets every 2 to 4 hours. If improvement follows after a few days then digitalis may be used with care, for, if the heart will stand digitalis, it is the remedy par excellent— give the preparation you know best and give enough to produce results, watching it closely. But, if the urine is not increased, the pulse better and the dyspnoea relieved some in 36 to 48 hours, the digitalis had better be stopped. The strychnine and the nitro glycerine are to be con- tinued with it. If the heart takes up and the dropsy disappears, the drugs may be gradually withdrawn and the iode of arsenic 2x substituted or the citrate of iron, quinia and stryc 2x given. If no improvement occurs and the dyspnoea becomes severe, even amounting to cardiac asthma with more or less pulmonary edema, then the case is desperate and desperate means must be resorted to. We have seen wonderful relief and beginning im- provement follow bleeding if 8 to 16 ounces of blood is withdrawn from the arm. The results of such a pro- cedure are marvelous and improvement begins at once. Insomnia is one of the most troublesome symptoms in these cases of ruptured compensation and rest becomes imperative. Bell chamomilla, coffee crude, or if this fail, codeine + to $ grain at bed time in broken doses often gives several hours of sleep. If this will not suffice, morphia, 1/6 of a grain hypodermically at bed time, will produce several hours of much needed sleep. The diet in these cases should be very light and easily di- gested. Attention should be given to ventilation, and the skin and everything should be done possible to keep the patient’s mind at ease. - Not all these cases will recover, but many of them will under such management and live for several years. 12 If, however, the case is 55 or older, the feet and legs are edematous, inability to lie down, dyspnoea and cough pulse soft, small and irregular, the impulse under the hand wavy but at times distinct, the apex only slightly downward and to the left of the nipple line, the murmur soft and blowing in character, the pulmonic second dis- tinct but not accentuated, the case is one of mitral regur- gitation, due to chronic endocarditis or endocarditis and myocarditis. The management of such cases is not very satisfactory and the mortality rate high. The liver and bowels should be relieved by the podophyllin or eleaterium 1/20 grain doses, care being taken not to ex- haust the patient; whiskey in liberal quantities, nitro glycerine 1/250 of a grain every 4 to 6 hours, strychnia 1/60 of a grain combined with it. The best remedy for the greater number of these cases is crataegus tinc- ture, giving from 10 to 20 drops every 2 to 4 hours. If it fail to give results, digitalis may be tried (the infusion being the better preparation). It should be used with extreme care. The general nutrition in these cases is always poor and must receive special care. The in- somnia is one of the most troublesome symptoms and must be met in some way; codeine or morphine as has been advised at bed time. The urine often contains a plain trace of albumin, but no casts, no kidney lesion is present, the albuminuria being due to the passive con- gestion of the kidneys and the deficient alcolinity of the blood and should receive no special attention. The management of mitral regurgitation and mitral stenosis in children is often a hard proposition, owing to the difficulty of obtaining absolute rest. One of the grave questions to answer in the manage- ment of mitral lesion is how much exercise can be taken when the patient is apparently in good health? We often 13 hear it said that a well compensated heart is as good as one in which no lesion exists. Such is not the case. If it were true why do such hearts give way? Every per- son with a mitral lesion has a crippled heart and his first duty in life ought to be to see that compensation does not become unbalanced. Therefore, how much exercise these cases can take is a grave question. The rule is often given that when dyspnoea occurs it is time to stop. That is going too far. When dyspnoea occurs even to a slight degree, the right heart is overworked. The best way is that when a person with a mitral lesion begins to get tired, it is time to rest. The amount of exercise must be according to the extent of the lesion. The greater the amount of hypertrophy of the right ventricle, the more care should be exercised in putting any strain upon the heart. In mitral stenosis, the exercise must be very limited. Attention to the general state of nutrition is important. Limiting the amount of liquids taken, is often of great service. See that the liver is active, the digestion good. Iron of some form is usually of great service. If individuals, suffering with mitral lesions, would make it a rule to stay in bed one day a week or go to bed at least two nights a week at 7:30 or 8 and live a moderate life, free from excesses of all kinds, we would have many less cases of ruptured compensation. 14 THE TREATMENT OF PULIMONARY TUBERCULOSIS. Ever since Robert Koch in 1882 established the etiology of tuberculosis, physicians, chemists and lay- men have been endeavoring to discover a remedy or a combination of remedies that will destroy the tubercular bacilli and their ptomaines without destroying living tissue. Kings, princes, individuals and governments have offered large rewards to the successful discoverer of such a remedy, but up to the present time no one has been able to prove his claim to the prize. That tuberculosis should be the cause for such wide- spread research work and the expenditure of so much money in an endeavor to master the Great White Plague is not surprising. In 1900, 111,059 deaths occurred in the United States from tuberculosis, or about one-ninth of the deaths from all known causes—costing the United States in money from a hundred and fifty million to two hundred million dollars. Millions are spent each year on secret cures, nostrums, and so-called specific treat- ment for this disease. Men and women of wealth have spent and are spending vast sums in exploiting cures that were thought to solve the problem. Men promi- nent in the profession have thought several times that the solution was at hand, but the serums, the lymphs, the tuberculin extracts, have all been tried and found want- ing; yet when one makes a careful study of this dreaded disease he is astonished at the results obtained by Nature in her own way. For example, Naget in a study of five hundred bodies dead from all causes, found that tuber- 15 culosis had existed in 97 per cent of the cases. In one year of our own experience in Cook County Hospital, 97 cases were followed to the Morgue, of persons who had died from various causes, and 68 were found to have had tuberculosis at some time in their life. That thousands of cases of tuberculosis, pneumonia, streptococcus, diph- theria, typhoid fever, tetanus and other septic blood dis- eases do recover by Nature’s own process, leads us to hope that some day some one will unlock her secret, and discover what it is that she in her wonderful laboratory, the human body, uses and how she uses it to bring about cures in these diseases. - That there is something that we take into our bodies that can be and is made into a wonderful germicide ca- pable of destroying germ life, and of overcoming the destructiveness of toxins without destroying human tis- sues, we know; and some day the glass that is now dark will become clear. - It would require volumes to report all the so-called cures investigated by us during the past twenty-nine years. It would take much time to discuss the results obtained by different men and different methods of treat- ment, so we shall confine our report to methods that have produced known results. Before discussing the treat- ment, there are a few diagnostic and prognostic points we wish to call attention to, born of experience. There are three principal ways of tubercular invasion. First, the insidious; second, that following a cold, pneu- monia, or bronchitis; third, as a storm. The insidious form comes on with a feeling of general malaise; tired, loss of ambition, poor appetite, restless sleep, irritable, moody. In these cases the early morn- ing temperature is subnormal, 97, 964, 96. This condi- tion may last for several weeks before cough begins. 16 The cough is dry, hacking in character, with little or no expectoration. Careful examination of the chest will show a spot or two in one or the other apices or under the clavicle, most often at the junction of the outer with the middle third or under the lower angle of the scapula. No pronounced dullness is present on percussion; no positive bronchial breathing is to be found, but a posi- tive increased whispered fremitus will be found. The progress of such a case is: Morning temperature sub- normal, evening temperature 99, 99% to 100; morning temperature normal, evening temperature 100 to 101; if the morning temperature remains at or near normal— 98 to 98%—no extension has occurred and no new spots have become infected, and breaking down of the tubercle will occur, with discharge through the bronchi, encapsula- tion and ultimate calcification. If the evening tempera- ture becomes normal for a time and the morning tem- perature is 98 or normal, then the evening temperature again increased to 100 or 101, secondary infection has occurred, streptococcus, pneumococcus, etc. If the early morning temperature again becomes subnormal, a new spot of invasion has occurred. The second form of invasion (that following a so-called cold, bronchitis, or pneumonia): Whenever a supposed cold or bronchitis becomes unilateral, tubercular infec- tion can be strongly suspected, and the whispered fremi- tus will locate the invading spots. An unresolved pneu- monia offers a splendid media for a tubercular infection. The return of a dry, hacking cough with a subnormal morning temperature and an increased evening tempera- ture points to tubercular infection, if there be no effusion. The third form of invasion (the storm) comes on very much like typhoid fever. After several weeks of poor appetite, headache, some cough, the morning tempera- 17 ture is 100 to 102, the evening 102 to 104. The abdomen is distended, the stools are apt to be loose, Sweating often occurs and some mild delirium, and the case is often mistaken for typhoid. But in spite of liquid food and general typhoid treatment the fever persists. The cough is not bad, but is present and most often loose. The Wiedal reaction is negative. But the whispered fremi- tus will positively locate the spots of infection in the chest. In a few weeks the fever subsides to a great ex- tent, and the case runs the typical course of pulmonary tuberculosis. The prognosis of a case of pulmonary tuberculosis de- pends upon the number of points of infection. The greater the number of spots, the poorer the chances are of recovery; yet personal resistance plays a great part in the prognosis. t The three cardinal principles in the treatment of pul- monary tuberculosis are, first, fresh air; second, good food; and third, rest. Fresh Air. So much has been written and said re- garding fresh air in the treatment of this disease, that any additional remarks would seem superfluous, yet a few valuable points gleaned from observation: First, in a dry, comparatively pure air outdoor living gives the best results in most cases, but not in all. If a tuber- cular patient living and sleeping out of doors awakens in the morning tired and languid, try him indoors. Re- member that it is far better to live indoors with open windows screened with cheesecloth to filter out dust, smoke, soot, etc., than to live outdoors in a damp place or breathing dirty, smoky, dusty air. Also remember that a sleeping porch on the second floor or on the roof is much better than a tent on the ground, unless it be in a dry, clear, pure air. Outdoor sleeping on the ground 18 has been and is being overdone; better progress can be made on the porch or in a room with windows open. No case of pulmonary tuberculosis can expect to improve in impure air. That Nature does cure many cases without their sleeping in the open, we know. Food. Here we touch a mooted question. That every patient suffering from pulmonary tuberculosis requires not only good food sufficient to meet the daily expendi- tures of bodily energy, all will admit; and that they re- quire an excess of easily digested and assimilable foods, we all know. The routine egg and milk diet offers the greatest amount of food in the simplest form; but all patients cannot properly digest and assimilate quantities of milk and eggs. Many can manage very good quan- tities if the bowels and liver are well looked after. Others can care for only small quantities. Some can take cream without milk, some can take raw eggs in sherry, in grape juice, lemon juice, malted milk, etc.; but he who orders milk and eggs to all of his tubercular patients will fail. Each case is a law unto itself. We have had good results, even better results, with scraped raw meat in place of too many eggs; rare cooked meats of all kinds; fruits in abundance, especially grapes, oranges and apples. Too much stress cannot be put upon the fact that all tubercular patients have more or less impaired digestion, and special attention must be given to this condition, and that large quantities of un- digested food is harmful, and that no digestive organs will work well unless the waste is properly carried away. Occasional colonic flushings have done much good. There is much difference of opinion regarding the use of wine, whiskey, etc. Where a certain amount of wine or whiskey aids digestion and does not increase tempera- ature or pulse, they do good; they should, however, be 19 taken with the meals only. Oatmeal in any form is a most nutritious food for these cases; it can be taken in large quantities, with milk, in cakes, fried in butter, in bread, crackers, etc. Cornmeal, as hominy with milk or fried in cakes with butter, or as cornbread, and cheese of any kind if acceptable, usually is beneficial. Rest. As fresh air is necessary for the improvement of a tubercular patient, and good food required to fur- nish the energy to combat the disease, so rest is im- perative to conserve tissue waste. We have known many good men, careful, painstaking, who have given their most careful attention to the air and the food their tuber- cular patients received, but failed to obtain results be- cause they neglected the matter of rest. Rest for the tubercular patient does not only mean sitting quietly in the tent or on the porch, getting up to attend to this little need, or that requirement, seeing company, sew- ing, writing letters, and so forth. It means that so long as the evening temperature is above normal, absolute rest is imperative. Sitting in a chair in the tent, well pro- tected from the weather, is all right if the temperature is not above 100 in the evening. If it is, the recumbent posture is imperative; if the best results are to be ob- tained, rest in the recumbent or semi-recumbent posture is to be insisted upon so long as the temperature is above normal. You may have good air, good food and care, in fact every possible adjunct to the treatment, but you will not obtain the best results unless absolute rest is secured. When to permit a tubercular patient to exercise is a Question for thought. Usually when the temperature has been 98 to 99 in the evening for a week or more, some exercise may be permitted, say a walk of one-half to one block. If the temperature goes above 100 after a walk, 20 quiet should be insisted upon for two or three days. If the temperature does not go above a hundred, the walk may be increased a few yards each day, watching the temperature. Should the temperature go above a hun- dred after a walk, too much exercise has been taken. Complications. The most common complications of pulmonary tuberculosis are, first, cough; second, hemor- rhage; third, mixed infection. Often in the early stages of the disease, the cough is the only troublesome symptom, and the doctor is im- portuned to stop the dry, hacking, annoying cough that prevents sleep, racks the body and often results in vomiting. The temptation to use some opiate or cough syrup containing various and Sundry sedatives is strong. We all know that no remedy has been proven that can produce tuberculosis. But we do know that he who carefully studies his Materia Medica and selects his remedy according to the totality of the symptoms in each case will obtain for his tubercular patient the greatest relief for the cough. For instance, a dry, hacking, teas- ing cough with little expectoration, accompanied by rest- lessness, calls for aconite; an explosive Cough in parox- ysms with dilated pupils, for belladonna; a hacking cough with tickling in the throat or trachea, for bryonia; a harsh hoarse cough, for phosphorus; a croupy spasmodic cough, for spongia; a loose cough with a tendency to nausea, for ipecac ; a dry cough worse on lying down, for Hyos; waking up with a croupy cough resulting in a little ropy expectoration, for Kali bichromicum. In the severe cases when the coexisting bronchitis is extensive and the alveolar inflammation large, with large quan- tities of expectoration, some sedative may be required. In these cases we have often found atropine, 1/250 to 1/150 of a grain, one dose at bedtime, gives sleep. Codeine, to 4 of a grain at bedtime; Hyos 1/400; heroin 1/12 at bedtime; steaming, as we will speak of later, often gives results. Hemorrhage. When the tubercle breaks down a small hemorrhage often occurs, from a drachm to an ounce. It usually has ceased to be active before the physician arrives. Ipecac, hamamelis, are usually all that are re- quired, but in those cases where a number of tubercles coalesce and a large blood vessel is destroyed, extensive hemorrhage may occur. The use of from 15 to 30 minims of sterile ergot hypodermically, or one-half an ampule of pituitary extract, will usually control it. The ice bag is not to be forgotten. Mia!ed Infection. We believe that but few of the people who die each year supposedly from tuberculosis do die of tubercular infection, but that the breaking down of the tubercle and the secondary infection with strepto- coccus, staphylococcus, pneumococcus, and so forth, and the resulting septic conditions, is responsible for the fatal termination. It is impossible to prevent secondary infection. The tubercular cavity communicating with the bronchi forms the best possible breeding ground for all kinds of micro- organisms. Therefore the question is how to manage the results of a secondary infection. Pure air helps. Good food assists. In fact these with rest are Nature’s methods. Some considerable experimental work is being done in these cases by artifically collapsing the affected lung by nitrogen injections into the pleural cavity; the results as yet are not very satisfactory owing to many reasons. We believe that inhalations of steam or warm air laden with various sedative mild germicides, as oil of eucalyptus, oil of tar, oil of pine needles, iodine, mer. cury in solution, acetic acid, hydrochloric acid: offers 22 the best method of combating the mixed infections and of relieving the coexisting bronchitis. Personal Ea:perimental Work. For over twenty-five years the writer has been conducting personal experi- ments in the treatment of tuberculosis. After many trials and tribulations he hit upon a preparation of mer- cury made by dissolving bichloride of mercury in beech- wood creosote and treating it with hydrated calcium chloride and powdered albumin, making a peculiar mer- curous mercury. With this preparation, which he called Albumasine, used as a spray douche, and by steam in- halations, we have succeeded in Guring a number of cases of tuberculosis of the nose, throat and larynx. Quite a good many cases of pulmonary tuberculosis also were given this remedy and recovered, but with it was used the best adjunctive treatment known. When cavities exist and mixed infection is present, steaming with this peculiar mercury does much good, but while it can be used hypodermically and intravenous, it does not possess the power of destroying tubercular bacilli unless it comes in direct contact with them. - For several years past we have been experimenting with an iodine preparation made in much the same way. The iodine has given some good results, and we hope to be able to perfect an iodine compound that will be of great service in tuberculosis. It is a well-established physiological fact that the secretions of the suprarenal capsules represent the key to tissue respiration; that they control to a large degree the action of the heart, lungs, liver and so forth; that the oxygen carrying prop- erties of the red blood cells as well as that of the blood plasma depend upon the suprarenal secretion. The suprarenal capsules are controlled by the anterior pitui- tary body through the solar plexus, the splanchnic nerves, 23 and the cerebral, thoracic, ganglia of the sympathetic. The anterior pituitary body governs the suprarenals. Therefore it controls oxidation, and the standard of health is maintained by the pituitary body. The thyroid gland sustains the functional activity of the anterior pituitary. The thyroid secretion is iodine in organic combination. These being facts, iodine is the most important element in the human body; therefore we believe that there is a strong probability that Nature’s unrivaled antitoxin or germicide is some form of organic iodine. For many years it has been known that a sea voyage is very beneficial to a tubercular case. From time immemorial, cod liver oil has been used for these cases, often resulting in cures. High pure air, dry air, and even excessive feeding, mean more iodine. Iodine also favors calcification in the tissue, assists elimination, stimulates absorption; so that we believe that when the secret of Nature’s laboratory is unlocked, iodine will be found to be the normal body germicide. 24 DIAGNOSIS AND TREATMENT OF TYPHOID FEVER. There are but few subjects in medicine more common or more frequently discussed by medical men than Typhoid Fever and there is, perhaps, no acute disease that the physician is called upon to treat that he permits himself to get into so routine a method as he does in treating this disease. The results of the present day methods of treating typhoid fever are so uniformly good and the mortality so far below that of but a few years ago that the physician allows himself to believe that, as his results have been so good for so many years, and his routine treatment so successful he may rest upon his experience rather than study each individual case; but, unfortunately, once in a while a mistake is made in the diagnosis, or what ought to be plain indications for a change in remedies are over- looked, and a life that should have been saved, passes away. Our only excuse for presenting this paper to this society is that typhoid fever still ranks with pneumonia as one of the two most common acute inflammatory dis- eases the human race is at present subject to. Diagnosis. We do not intend to discuss the diagnosis of those typical cases with the characteristic prodromatic symp- toms, or temperature, or epistaxis or diarrhea, rose spots, etc. These are the cases where the novice will rarely fail to make a correct diagnosis even without the 25 3 -> laboratory findings. But it is those atypical cases, that come on in an irregular way without any or but few prodrome, run an irregular course and often become seriously ill because of our failure to make a correct diagnosis. If one will keep in mind the fact that the diagnosis of typhoid fever, except in rare cases, can seldom be made with any degree of certainty before the end of the first week, and often not before the middle of the second week and every suspected case treated as a typhoid, the mor- tality rate of thirty-four and eight-tenths per cent will be materially reduced. Without going into an extensive differential diagnosis of the diseases, let us describe some of the more common affections from which it must be differentiated and per- haps, one or two rare conditions. First. The intestinal form of la grippe. We have all seen many cases of la grippe, which by the end of the first week presented an almost typical picture of typhoid fever. The laboratory findings show the diazo reaction as negative, the wedal reaction not positive, but some clumping of the bacilli are seen; or, perhaps the technique has been faulty and a negative report obtained. Still the clinical picture is so much like typhoid fever that we are loath to abandon our diagnosis. If by the end of the second week the temperature touches the normal in the morning and the skin has remained more or less moist during the course of the disease, the case is one of acute intestinal la grippe; but if the temperature persists after the second week, even if the skin is moist, and the diazo reaction absent and the wedal not positive, a diagnosis of typhoid fever is, in all probability correct, for it should be borne in mind that la grippe and typhoid are often co- existing in the same patient. We do not wish to be mis- 26 understood: we expect to find the wedal reaction present in typical typhoid, but our experience has been that in the exceptional case it is not and, while we appreciate the value of the laboratory findings not only in this dis- ease, but in many others, yet we believe that the labora- tory findings must fit the clinical picture to be confirma- tory evidence. In other words, we hold that in the greater number of the cases laboratory findings should be confirmatory evidence rather than diagnostic. It has been our privilege to see, during the past four years, in consultation, four cases, and one in our own practice of what proved to appendicular abscess mistaken for typhoid fever. In three of these five cases the wedal was reported not positive, but suspicious; in two it was reported as positive. In four of these cases no leukocyte count was made until after three, four and six weeks had elapsed. In the remaining case the white count was made within the first week. It has also been our priv- ilege to see, within the past four years, two cases which had been treated as typhoid fever and perforation was supposed to have occurred; one case was posted and a large appendicular abscess found; the other operated upon for perforation and a large appendicular abscess that had ruptured into the general peritoneal cavity found, drained and recovery occurred. The results of these experiences have taught us that if a case presents any of the ear marks of typhoid fever and the diazo is absent, the wedal negative or not posi- tive, a white blood count must be made. * We have also seen two cases of acute trichinosis within the last four years, diagnosed and treated as typhoid fever for several weeks. Aside from the fact that the spleen is rarely enlarged in trichinosis, and the muscular pains are, as a rule, more pronounced, the two diseases might often be confounded. At present the evidence seems to show that in trichinosis the eosinophales are largely increased. We shall omit considering the differential diagnosis between typhoid fever, septaemia, endocarditis, pneu- monia, empyema and puerperal fever, although we might spend some very valuable time in the consideration, particularly of septic endocarditis; but we will speak of one more class of cases, namely para typhoid. These cases are very much like typhoid fever, but, as a rule much milder and less fatal. A reaction similar to the wedal is obtained with the para colon bacilli. Treatment. The United States Government statistics for 1900 to 1904 show that the average death rate in thirty-eight cities in this country in typhoid was thirty-four and eight-tenths per cent, and that it costs the United States each year $200,000,000.00, yet, when the mortality of the last twenty years is compared with the mortality rate of forty to fifty years ago it shows a marked improve- ment. If Homeopathy had done nothing else in the world but lower the death rate in typhoid fever, Samuel Hahnemann and his followers did not live in vain. We do not mean that all the lives that have been saved have been saved by Homeopathic medicine, but homeopathic physicians have taught and are teaching the medical world that heroic dosing is not only unnecessary in the treatment of typhoid fever, but that the mortality rate is much lower under other treatment. It is in prescribing for our typhoid fever patients that we are apt to become routine and treat the disease rather than the patient. To our mind if the Homeopathic law means anything, it means that we treat the case and not 28 the disease. We have known one most excellent prac- titioner who treated all his typhoids with baptisia, and during one fall lost four cases that ought to have been saved; another who believed for several years that he had a sovereign remedy in echinacea for all cases of typhoid fever, but who had his confidence badly shaken. We have heard many physicians of the dominant school and not a few so-called Homeopaths say that typhoid fever is a toxin and that they did not believe that any medication was of avail in the disease. After nearly twenty-five years of active practice, in which we have had our share of typhoids to treat, and after four years on the Cook County Hospital staff, with a large number to treat, not under the best circumstances possible, we unhesitatingly say that, while typhoid fever is a toxemia, the course of the disease can be often cut short and with- out any doubt the severity can be materially lessened and convalescence shortened. - We believe that it is good practice when called to see a case of typhoid for the first time, if the intestinal tract has not been thoroughly cleansed it should be. We are in the habit of giving one grain of calomel in broken doses, one-fifth of a grain for five doses; then a half an ounce of castor oil. After this is done we may select our remedy. g If the patient is restless, the skin dry and hot, the pulse hard and rapid, the headache tense, ACONITE is the remedy, and we have known a number of cases where the wedal reaction was positive that we felt sure the remedy cut the disease short in two weeks, before suppuration of the intestinal glands occurred. Perhaps no homeopathic remedy is as commonly used in typhoid fever as Arsenicum Alb, yet our experience has been that it is not so often indicated as some others. 29 . If the patient is restless, thirsty for small quantities of liquids, diarrhea serious and often involuntary with a very strong odor, delirium of the negative type, wants to get out of bed—then ARSENIC is the drug. If the tongue is moist, the bowels loose, the patient complains of pain, is sore and complains on being moved and of the muscles and body being sore, ARNICA is the drug. If the lips are cracked and bleeding, the tongue, teeth and gums covered with bloody sordes, AURUM TRIFOLIUM is the remedy. If the pupils are well dilated, the headache frontal, the Sclerotic coats of the eyes injected, the skin dry, backache persistent and delirium marked, BELLADONNA is the remedy. If the tongue is dry, the thirst great and for large quantities of water, the delirium early and about one’s work with a constant desire to go home, frontal head- ache, wants to lie still, diarrhea early and often epis- taxis, BRYONIA is the remedy. If the tongue is brown with a dark red streak down the middle or the whole tongue is red and as if it had been skinned, the delirium of the low muttering type, with a constant inclination to slip down in the bed, BAPTISIA is the remedy. - If the headache is in the occipital region, the skin moist, the pulse full and soft, the temperature not run- ning very high, the backache severe, GELSEMIUM is the remedy. If the tongue is a dirty yellow with red tip and edges, marked, PROTo ToD MURC will do good work. When the delirium is pronounced and the case passes into stupor, with the pupils either contracted or dilated, 30 the jaw dropped, the bowel movements involuntary, OPIUM is the drug. When hemorrhage occurs with a gush of bright red blood PHOSPHORUs has done good work. When the case has reached the third or fourth week and the diarrhea is persistent, two to six movements in an hour, yet the patient seems to be strong, PHOSPHORIC ACID has done good work. If the tongue has the characteristic triangular tip, the abdomen is distended, the rose spots abundant, RHUs Tox. is indicated. If the urine is thick, the tongue smooth and glazed, the backache pronounced ATROPINE is the drug. We do not mean that these are the only remedies indi- cated in typhoid fever, but that they have been the ones most often indicated in our experience and have given us good results. The indications, as given, have been many times proven and are from our own observations. We do not believe in the use of combination tablets of any kind and can see no place for them in typhoid fever. We recognize the trend of the times toward poly-phar- macy and fully appreciate the fact that the Homeopathic physician who can conscientiously use combination tablets will save himself much time and materially as- sist the dominant school of medicine in absorbing us. The two most common and dangerous complications of typhoid fever are, first hemorrhage, and second, per- foration. We will consider the latter first. The mortality rate in perforation is very high. Sur- gical interference may be of service; otherwise every ef- fort possible to sustain the patient is to be resorted to until recovery can be obtained. The treatment of hemorrhage must be prompt and the remedy well chosen. Phosphorus has been spoken of. 31 UNNERs. OF McHIGAN Our own best results have been from hamamelis; we usu- ally give Pond's Extract, one dram every half hour and have seen wonderful results following its use. The use of the ice coil, elevating the foot of the bed and the ad- ministration of strychnine, 30th, hypodermically as often as every two hours for six or eight doses to keep up the heart, either alone or in combination with 120th of atropine (not using more than one or two doses of the atropine). Diet. If we are apt to become routine in our prescribing for typhoid fever, we are more apt to become routine in our directions as to diet. In Cook County Hospital as well as in our own practice, we have learned that a routine diet is not best for all cases of typhoid fever. We per- mit all kinds of strained fruit juices—Orange, lemon, grape fruit, pineapple, grapes, strawberries, cherries, etc.; broths of all kinds, bouillons, plain tomato soups, oyster broth, buttermilk, lactonized milk, koumiss, with plenty of distilled water and an abundance of chipped dried beef and chewing gum to chew. We do not use sweet milk in any quantity. As to the temperature; it is kept as low as possible by sponging or the abdominal coil. If the bowels are con- stipated, enemas of normal salt are used every other day, with a dose of castor oil every four or five days or, if necessary, every day. The so-called stimulants, whiskey, brandy, wine, etc., we have never seen do any good. 32