LEATHER-HEAD'S A NEW SYNOPSIS OF NOSOLOGY, FOUNDED ON THE PRINCIPLES OF PATHOLOGICAL ANATOMY, AND OF THE NATURAL AFFINITIES OF DISEASES. BY G. HUME WEATHERHEAD, M.D. MEMBER OF THE ROYAL COLLEGE OF PHYSICIANS, LECTURER ON THE PRINCIPLES AND PRACTICE OF PHYSIC AT THE WESTMINSTER SCHOOL OF MEDICINE, CORRESPONDING MEMBER OF THE ZOOLOGICAL SOCIETY OF LONDON, &c. LONDON: PRINTED FOR S. HIGHLEY, FLEET STREET; CHURCHILL, PRINCES STREET; RENSHAW, STRAND; AND COX, ST. THOMAS STREET, BOROUGH. 1834. TO W. D. WEATHERHEAD, ESQ. MY DEAR SIR, SITUATED as we are in the world, without other family relation than that in which we stand towards one another, I embrace with sincere pleasure the opportunity of dedicating the following Work to you, as a small tribute of my regard ; and remain, My dear Brother, Ever affectionately yours, G. HUME WEATHERHEAD. 9, Upper Bedford Place, Russell Square, 1st May, 1834. 2091 033 INTRODUCTORY REMARKS. THE word Nosology, according to its derivation, simply means a discourse on diseases ; but, by conventional acceptation, it is used to signify their systematic classi- fication. From the earliest periods in the history of medicine, when diseases came to be treated of in books, irregular vestiges of this department of medical science are to be found ; and hence we observe the father of our art, Hippocrates, arranging diseases in groups, founded on some real or supposed analogy between them, or treating of them collectively, as they affect particular organs or parts of the body. As a know- ledge of the nature of diseases became more correct and extended, we find, in later successive writers, greater precision and method in their classification ; but Nosology, as a distinct branch of medical science, takes its origin from a period comparatively modern. Plater, who wrote in the beginning of the seventeenth century, was the first to sketch the penumbra of what is now understood by a synoptical classification of dis- eases. In his work on the Practice of Medicine, pub- lished at Basle in 1602, this author succeeded in making a first step towards a systematic arrangement of dis- eases, especially those affecting the nerves of sense and motion. vi INTRODUCTORY REMARKS. But it was Francois Boissier de Sauvages who com- piled the first professed Synopsis on the classification of diseases. This work appeared in 1731, merely as outlines, which he subsequently republished, after taking above thirty years to complete it, in 1762, under the title of Nosologia Methodica. This illustrious writer's arrangement comprehends ten classes a sub- division which of itself shews its vagueness ; yet our admiration and gratitude are not the less due to Sau- vages for having been the pioneer in this arduous and difficult undertaking ; and to evince how far he ac- complished it, it is only necessary to remark, that he formed several entire classes and orders which have been adopted by every nosologist who has succeeded him. The Synopsis of Linnaeus and Vogel appeared almost immediately afterwards ; the one at Upsal in 1763, the other at Gottingen in 1764, without either of these having made any manifest improvement in the classification. Linnaeus even augmented the nnmber of classes to eleven ; and many of his genera are no- thing more than symptoms, such as anxietas, languor, lassitude, stupor, pruritus, tussis, stertor, delirium, &c. Vogel makes a similar number of classes, and also enu- merates a variety of mere symptoms as diseases, such as nausea, tenesmus, ructus, &c. ; but his definitions are to be admired for their descriptive terseness. Macbride, Sagar, and the illustrious Cullen, followed. Of the first of these writers as a nosologist, little need be remarked, since candour obliges us to say, that he has done nothing to advance pathological classification. Sagar, again, whose work appeared at Vienna in 1776, INTRODUCTORY REMARKS. VH although he makes so many as thirteen classes, shews throughout his work much admirable distinctness and method; and many of his definitions are models of lucid acumen of comprehension. Indeed, it may be observed of the general character of the several systems of noso- logy, up to the time of Cullen, that it was not so much in improving the classification of diseases, as in more accurately separating them from one another, and defining their distinctive symptoms, that any progress was made. Of Cullen we scarcely know whether most to admire the beautiful simplicity and clearness of his method, or the philosophical comprehension of his genius. As Sydenham has so deservedly obtained the appellation of the English Hippocrates, so may we, with equal justice, bestow on this immortal ornament of our pro- fession the title of the Scottish Father of Medicine. Cullen, with that precision of thought which so emi- nently distinguished him, reduced the number of classes to four ; but his methodical arrangement is too gene- rally known to make it requisite to particularise it. Various other Synopses of Nosology have been put forth by different eminent men in England, amongst whom Parr, Young, and Good, are the most noted. It is not my intention, neither would it afford me any satis- faction, to enter into an examination of the principles on which they are founded. It were hypocrisy to pre- tend an unqualified, or even modified, approbation of their several methods, seeing that I have adopted for myself, in this Synopsis, one so very opposite. I may merely observe, that of the three, the system of the last of these writers is the one that most outrages every viii INTRODUCTORY REMARKS. natural affinity; and although Dr. Good makes an objection to Dr. Cullen's arranging itch and broken bones (as he facetiously expresses it) together, it seems he himself saw no incongruity in classing toothach (odontia dolorosa) with prolapsus ani (proctica ex- ania), as species of the first and last genus of his first class and order. Elsewhere we find cataract, amau- rosis, staphyloma, and strabismus, all indiscriminately arranged as consecutive species of the same genus (parapsis). Indeed, throughout the whole work, ex- amples of the same incongruity are to be found ; but such was to be expected, as the unavoidable conse- quence of a synoptical arrangement founded on a sys- tem that could not possibly coincide, in most instances, with affinities either natural or pathological. Medical practitioners, of any experience, have long been aware of the obvious differences between the pathological alterations and terminations that take place when tissues, distinct in their kinds, become the seat of morbid action. The first writer who most impressively pointed out this circumstance, was Dr. Carmichael Smyth ; and the reader will find an ex- cellent paper on this subject in the second volume of the Medical Communications, p. 168, published in 1788 ; but the subject did not entirely escape the no- tice even of the earlier nosologists, for we find Sauvages separating the phlegmasiae into the membranous and parenchymatous. Pinel, some years afterwards, and apparently without the least knowledge of Dr. Car- michael Smyth's paper on the subject, adopted a pre- cisely similar principle in his Nosographie Philoso- phique, in treating of the inflammations as they affect INTRODUCTORY REMARKS. IX distinct tissues, which, in the first edition of his work, was confined to the pathological differences specifically distinguishing the mucous and serous tissues only. It was from this outline, furnished by Pinel, that Zavier Bichat extended the idea to the analysis, natural and pathological, of all the tissues of the body ; and eighteen months after the publication of Pinel's work, his treatise on the membranes appeared, a model of precision, originality, and of philosophical analysis as applicable to disease, hitherto unknown in the develop- ment and illustration of pathological anatomy and phy- siology. Carmichael Smyth and Pinel were the first, as I have already observed, who pointed out the identity of the physiological and pathological characters of similar tissues, though situated at a distance from each other. Yet it is to Zavier Bichat, the John Hunter of France, that is due the distinction of perfecting these new views, by forming them into groups and classing them in systems, each performing its characteristic function in health, and presenting its own peculiar pathological pheno- mena in disease. A persuasion, very generally enter- tained, is, that a minute knowledge of anatomy is neither essential nor useful either to the physician or surgeon. I hope to be able to shew, in the sequel, that this is a mistaken notion ; and that an accurate and intimate acquaintance with the most minute and deli- cate structures of the body, is absolutely required to understand, not less the laws of morbid action than those of natural physiology ; for if we trace the multi- form phenomena, either of health or of disease, up to X INTRODUCTORY REMARKS. their elemental agents, we shall find these to be the ultimate extremities of every active organic structure. The study of the pathognomonic characters of the diseases of particular tissues teaches us to distinguish, by symptoms, when the morbid action extends to another tissue that is contiguous, yet different, as we see when the inflammation of the conjunctival coat of the eye extends to the sclerotic, as well as when it creeps from one organ to another where the tissue is similar, as from the peritonaeal tunic of the under sur- face of the liver to the outer tunic of the stomach, or from the upper surface of the liver to its expansion over the under side of the diaphragm ; and hence the nausea and vomiting in the one case, and the cough and hiccup in the other. But the parts of the animal machine the study of which has thrown most light of late on pathological physiology, are those of the different tissues, in relation, first, to their structure, and afterwards to their func- tions. It is by knowing these that we are enabled to perceive the natural alliance which exists between ana- tomy, physiology, and pathology, and by which we come analytically to connect symptoms with the dis- order or disorganisation of organs, since each tissue, we find, has not only a mode of disease daction peculiar to it, but likewise possesses its own particular sensibilities and irritabilities. For example, exposure to the ex- ternal air causes little comparative uneasiness in the mucous tissues ; the uterus, or the lower portion of the rectum, may prolapse, and remain so without causing any acute pain or inflammation, while the access of INTRODUCTORY REMARKS. XI the atmospherical air to a serous or fibrous structure is altogether different allow it but to enter the cavity of the abdomen, or of a joint, and you have inflammation to a violent degree excited, and pain the most excruciating. Different structures, again, are sensitive to stimu- lants of very opposite kinds. The fibrous structures, for example, such as the ligaments, can bear to be cut with a knife, or cauterised, with perfect immunity from pain ; but they can neither be extended or distended with the same impunity ; while the liver, the lungs, and heart, the hemispheres of the cerebrum and cere- bellum, the ganglions and filaments of the great sym- pathetic all these parts, in a healthy state, are per- fectly insensible to mechanical irritation : they can be cut, stretched, or torn, without causing pain. It is told of Bichat, that he was nonplused one day by a question put to him by a patient he had just operated upon why he should have felt so many dif- ferent kinds of pain in the division of the different parts of the limb which had been amputated why the pain was not the same in the section of the skin, of the nerves traversing the subcutaneous cellular mem- brane, the muscles, the bone, and the marrow? Bichat was compelled to acknowledge his ignorance. Subse- quent reflection on this subject, aided by Pinel's pre- vious attempt at its elucidation, led this comprehensive and original thinker to the discovery that each tissue had its own peculiar vitality, and was endowed with its own particular sensibility the two grand principles on which depend all the phenomena characterising their states both of health and disease. It is to these xii INTRODUCTORY REMARKS. peculiarities that is to be attributed the multitude of words by which we designate pain ; the sensation may be burning, corroding, pricking, itching; it may be excruciating, throbbing, pungent, lancinating, tensive, wrenching, racking, gnawing, tearing, griping ; it may be acute, dull, heavy, or obtuse : all of which, and many more, were it necessary to enumerate them, depend mainly on the nature of the tissue which is the precise seat of the sensation. It is upon these circumstances, too, that the cha- racteristic symptoms of a disease so frequently depend, as well as their tendency to terminate in a particular manner. The pain, as I have already observed, of inflammation of a mucous tissue, is never so acute as when a serous or fibrous membrane forms the seat of the morbid action. The pain attendant on a severe catarrh is not near so violent as that on a slight pleu- ritis ; phlegmonous inflammations are apt to terminate in suppuration ; the fibrous can scarcely be said to do so at all, if not involved in the process by the ulcera- tion of contiguous parts. The identity of all morbid phenomena depending upon conformity of tissue, and of the organic function of parts, though distant and isolated from each other, not only establishes the respective affinities which so many diseases have one with another, but it also illus- trates the connexion between a suite of symptoms set up in the same disease. Gonorrhoea, for example, which is a virulent inflammation of the mucous lining of the urethra, is readily transmitted by contagion to the mucous lining of the eye-lids; and, on the other hand, the matter of purulent ophthalmia, if applied to INTRODUCTORY REMARKS. XH1 the urethra, will produce a like disease in the part. All the leading symptoms of measles, again, are varied affections of the mucous tissues, and the particular manner in which they are grouped forms the specific character of this disease : the suffusion of the eyes, the coryza, the soreness of the fauces, the hoarseness, and cough, are every one of them affections of the mucous membranes; so is the subsequent diarrhoea, when it ensues ; and the eruption itself has its seat in the thin mucous tissue connecting the vessels of the rete vasculosum. Here we have a concourse of symptoms demonstrating the utility of an analytic system of pathology founded on the principles of ge- neral anatomy. It has hitherto appeared an anomaly to many to class with scarlatina that form of it which simply affects the fauces, without being accompanied by any cutaneous efflorescence ; but when it is viewed in 'its real pathological character as a specific disease affecting a particular tissue of the skin, and when we know that this very tissue is prolonged into the fauces, the anomaly vanishes. Scarlatina, in this point of view, does not depart in reality, though it may in appearance, from its essential character ; but remains perfectly true to it, both pathologically and anatomically. It was ignorance of these circumstances that made Cullen class this disease, the malignant sore throat of so many writers, among his incongruous group of the Cynanches. Bichat divided all the functions of life into two great classes, the animal and organic. The first com- prehends those which relate to things external of the body ; the second has reference to the functions which serve to the continually alternating composition and XIV INTRODUCTORY REMARKS. decomposition of the different parts of the body. The brain he made the central organ of the one, the heart of the other. The physiological phenomena ex- hibited by the nerves, the muscular system, and the senses, he especially appropriated to the first ; digestion, circulation, respiration, exhalation, absorption, secre- tion, nutrition, and calorification,* to the second. But a little consideration will soon convince us that this division of Bichat's is more plausible than real, having no foundation in nature ; and its artificial character will be obvious the moment we apply it to the elucidation of disease. Every organic function, it is needless to say, is performed through nervous influence ; and the differences in the phenomena between the animal and organic functions are, therefore, mere modes of one and the same power. 1 hope to make obvious, in the sequel, the pro- priety, as well as utility, of founding Nosology on the properties of the tissues, as far as our knowledge of them goes : the similarity of their several symptoms when diseased, the resemblance in their results or effects, and, above all, the sameness of the principle requisite to be pursued in their treatment, in whatever part of the body the tissue may be situated, all demon- * I may take this occasion to remark, that calorification is, in the strict literal sense of the word, a secretion performed bv the capillary vessels a separation, in fact, of a portion of the caloric, combined in a latent form, from the mass of the blood, in the ac- complishing of which it seems probable the laws of electricity are concerned, since it is known that the blood, in passing from the capillary arteries into the capillary veins, passes from a positive into a negative state of electricitv. INTRODUCTORY REMARKS. XV strate the advantages derivable from a classification taking this principle for its foundation. On referring to systematic, and other writers, on diseases, we have recurring in almost every page occa- sion for surprise at the Protean form that the symptoms of the same disease are described as assuming now present, now absent, sometimes acute, at other times obtuse ; and if we come to examine how this happens, we shall find that it is attributable, in almost every instance, to the morbid action not being seated in the same tissue. This is more particularly observable in the diseases of compound organs ; but in all these cases, on properly locating the seat of the morbid action, all contrariety and contradiction in the symp- tomatology is got rid of at once. It is true the mor- bid action set up in one tissue will, and does fre- quently, extend to a different tissue immediately con- tiguous, and then the symptoms peculiar to each become mixed; but, even in this case, a knowledge of these peculiarities assists rather than confounds the correctness of our judgment as to the nature and ex- tent of the disease ; for it will always be found, that the assemblage of symptoms present was not of simul- taneous appearance, but that a part of them was superinduced on the other; thus shewing the pro- gression of the diseased action by extension or sym- pathy. I have already noticed the different degrees of sensibility and irritability possessed by the different tissues; and the consideration of this circumstance also tends to elucidate morbid phenomena. Disor- ganisations, for example, are most apt to occur in those XVI INTRODUCTORY REMARKS. tissues possessing no great degree of vascularity and little sensibility, or in those which possess more irrita- bility than sensibility. In all these instances, inflam- matory action obtains an irritable character rather than one of intensity and activity ; and such is ordi- narily the case when the diseased action lodges more in the purely sentient properties of the part than in its vascular structure. However, though great vascu- larity be in general accompanied with a corresponding degree of sensibility, this must be received with some modification. Thus, the lips are extremely vascular ; but then it is the skin covering them that is the most sentient part of them ; and hence it is we see these parts obnoxious to subacute inflammatory action of a malignant character, ending frequently in cancerous disorganisation rather than in healthy suppuration; but, with some few exceptions, it may be said that in parts which are equally vascular and sensible, inflammatory action is ordinarily of an acute form, and speedily ter- minates either in resolution, suppuration, or gangrene. The action, in the first case, is more indolent, but more obstinate, and yields less readily to those means known as effectual in controlling inflammation ; and even when entirely subdued to all appearance, it is a species of inflammation readily re-excited. The above is another example illustrating the important fact, that there is no detaching anatomy, physiology, and pa- thology, from each other in a practical point of view and the circumstances likewise indicate how much scope there is for the institution of a system of thera- peutics that shall connect the materiae medicae with the tissues, by shewing, not merely the general effects INTRODUCTORY REMARKS. XV11 of medicines on the common sensorium, but also the local operation of particular medicines on specific tissues. It now becomes necessary to say a few words in explanation of the plan adopted in arranging the fol- lowing Synopsis of Nosology. The author has found that he has been able, by following the natural affinities, to classify all the dis- eases resulting from the derangements proper to the body, spontaneous and incidental, under four principal heads. These form his classes namely, the PHLOGO- TICI, or pure inflammatory diseases ; the H^MAPHAR- MATICI, or those diseases which originate from a miasm or poison entering the healthy blood, and tainting it ; thirdly, the NEUROTICI, which comprehend all those diseases arising from affections of the nervous system, unaccompanied by any apparent structural disorganisa- tion.; while the last class, or the VITIA, comprises all accidental disfigurations, new morbid formations, ex- traneous lodgments, and congenital malformations. The first class, or the pure inflammations, consists of two orders fevers purely inflammatory, produced by the ordinary causes of idiopathic inflammation; and the inflammations of the membranous tissues. The diseases of the first order are few, and of rare occur- rence as idiopathic affections, particularly the first of the species, or Synocha, to institute which it is manifest that the subject of it must be in that perfect state of health in which there exists no morbid predisposition whatever ; so that, when the morbid phenomena are fully instituted, the inflammatory action shall evince no particular local determination a condition of the XV1I1 INTRODUCTORY REMARKS. system so seldom met with, and so difficult to sus- tain, as the habits of society are constituted, that we cannot wonder at the rareness of its occurrence. The diseases of the second order, again, which are infinitely more common, comprehend exactly all those inflammatory affections wherein the general equilibrium of the inflammatory action just spoken of has no existence ; in which, on the contrary, the morbid action is either confined to a particular part, without involving the vascular system generally, or, synocha being present, it is accompanied with some particular local determination, constituting, in fact, the mem- branous inflammations. This order is divided into two sub-orders the one including the inflammations of the tegumentary tissues, both idiopathic and sympa- thetic the other those of the internal membranes. It is this last sub-order that contains such a multi- tude of diseases, which, though all purely inflammatory, yet evince very marked differences in their pathological characters, owing to the great diversity in the struc- ture of the tissues affected. The author, taking Bichat as his guide, has divided these into the mucous, the serous, the fibrous, and the cellular, to which he has ventured to add another, the albuminous; and, although Bichat has many more tissues, the author has found the preceding sufficiently numerous for all useful pa- thological purposes. There is a class of diseases instituted within the body that are strictly humoral in their nature, pro- duced by miasms or poisons being introduced into the healthy blood, either by inhalation or by inoculation purposely performed, or accidentally inflicted. These INTRODUCTORY RKMAHKS. form the author's second class, or the Heemapharma- tici; and, differing as they do in their nature essen- tially from all other diseases, they can only be properly arranged by themselves. This class includes the fevers produced by miasms, whether of a vegetable or animal origin ; likewise all those exanthems occasioned by infection, contagion, or inoculation ; thus limiting the name to those efflorescences that ordinarily occur but once during life ; and lastly, it associates with these, but in a distinct order, the morbid effects of animal poisons, not febrile or exanthematous, which, on enter- ing the healthy blood, attack the vital principle. The diseases of the nervous system, like the Phlo- gotici, are numerous and varied, and form the third class of this synoptical arrangement the Neurotici. I have divided them into four orders. In the first the reader will find those affections which are characterised by -aberrations of the judgment; in the second, the diseases affecting the nerves of sensation ; in the third are placed the diseases proceeding from affections of the nerves of motion ; while the last, the most numerous list of the whole, comprises the diseases of organic function. In none of the nosological systems hitherto published do these form a distinct group, a circum- stance which has necessarily compelled the author to assume a new term to designate the order to which they belong ; and he has fixed upon the Greek word igy^TiJco? to form its denomination. A similar reason has obliged him to find other new names for some of the tribes into which the order is subdivided. The diseases proceeding from the function of sanguification, for example, are ranged under the tribe Hsemapoietici ; XX INTRODUCTORY REMARKS. those ensuing from the state of the circulation he has classed under the Hsemacyclici ; the functional diseases of the appetites form the Orectici ; the tribe Eccritici denotes the disorders of the secretions ; while the func- tional diseases of the womb connected with pregnancy are arranged under the Cyetici. The last three of these tribes do not require any particular explanation ; but as the diseases belonging to the first two have never yet been grouped together as functional diseases, even by implication, a few words may be necessary to ex- plain the author's views of the matter. The function of sanguification is capable of three different conditions : blood may be elaborated in excess, and thus induce not only a morbid predisposition, but a diseased state of the body itself, constituting, in fact, plethora; sanguification, again, may, through a debility of function, be defectively performed, thus constituting the disease called anaemia ; and, lastly, the function may be depraved, and instead of elaborating healthy blood, a corrupt fluid may be the result of the morbid process, and thus give rise to scurvy. All these three conditions of the blood, it may be observed, are not only diseases of themselves, but they embody morbid sequelae that are frequently of a more fatal tendency than the diseased state from which they ensue. Hence it is that we see a foundation laid by the first for secondary apo- plexy, that is, rupture of some of the blood-vessels within the head from engorgement and congestion, or for some violent internal inflammation ; while, in the other two, we find dropsical effusions into various cavi- ties of the body as their very ordinary consequence. The diseases induced from the state of the circu- INTRODUCTORY REMARKS. Xxi lation are not less interesting, and are of still more common occurrence. To the functional diseases of the circulation appertain all sanguineous congestions and fluxes, both active and passive, and their sequelee are perhaps still more fatal than those ensuing from the diseases of sanguification. Apoplexies and palsies are their sequences ; and if the sanguineous fluxes do not of themselves prove directly fatal, they are sure, by long continuance or frequent recurrence, first to induce an artificial state of anaemia, and consecutively to be followed by the sequelae of this state dropsical effusions. The mention of sequelae leads me naturally to re- mark, that diseases are not all primary in their nature, although, in arranging them, nosologists have never yet drawn the proper distinction between them ; on the contrary, a great number of diseases are entirely morbid results of the primary disease, and many are again the sequences of these very morbid results themselves. Each of these the reader will find arranged in the natural order of their sequences in this new Synopsis a method that has not hitherto been adopted by any preceding nosologist. But it may be well to elucidate my meaning more distinctly, by exemplifying it. Let us take sub-acute hepatitis as the primary disease : a common morbid consequence of this is the interstitial deposition of coagulable lymph into its structure, which, on becoming organised, constitutes scirrhus of the liver. This is a sequela of the primary morbid action, but it is not its ultimate result, as we shall see by pursuing the subject a little further. Scirrhosity gives a preternatural solidity and induration to the liver : this naturally presents a constant and powerful XX11 INTRODUCTORY REMARKS. obstruction to the free return of the venous blood from several of the abdominal viscera ; a mechanical haemo- stasis or congestion of necessity takes place in all the branches of the vena porta, which, in order to relieve themselves of the engorgement, force into the exhalants opening into the cavity of the abdomen an undue por- tion of serosity greater than the absorbents can remove, the morbid consequence of which is ascites. Here, then, we have two consecutive morbid sequelae, each constituting a specific disease, the one being the sub- sequelae of the other, besides the primary disease ; in- deed, it not unfrequently happens, that all these three morbid states shall simultaneously co-exist. The fol- lowing, therefore, presents an illustrative diagram of the subsequent synoptical arrangements : Species 1. HEPATITIS. Variety, a. Sub-acuta. Sequela, a. Scirrhus. Sub-sequela, a. Ascites. b. Htemorrhoea intestinalis. a. Recti. The reader will further perceive b. Hcemorrhcea intes- tinalis and a. Recti superadded, by which it is intended to indicate, that sometimes, instead of dropsy being the sequela, as explained above, intestinal haemorrhcea shall be the morbid consequence of the sanguineous engorgement; and the word " Recti" is placed to shew when this proceeds from a particular part of the intes- tines, that is, from the haemorrhoidal veins. This method of indicating the series of sequence and affinity is preserved throughout this Synopsis ; and the INTRODUCTORY REMARKS. XXU1 author has bestowed his utmost attention to deduce them in their proper order and place, so as to present to the reader not merely a correct nosological arrangement as to the nature of diseases in general, but a synoptical diagram, at the same time, of the relation they hold one with another, as consecutive series. The advantages of this arrangement to the younger members of the profession, and to students in medicine in particular, will be obvious, from its placing morbid phenomena before them based on the method of ana- lysis. It is only thus that the natural alliances of diseases can be perceived, by connecting them together according to their pathological character, by which their affinities become obvious and intelligible, instead of classifying them, as has been done hitherto, in a manner wherein their natural relations were so much disregarded. For what can more forcibly exemplify this, than the practice of indiscriminately classing the sequelae and sub -sequelae of diseases as genera or species, among those of a primary nature, to which they are imagined to bear some vague analogical affinity ? The dropsies, for example, are placed, even by the sagacious Cullen, in his order Intumescentiae, among which we find, most incongruously assembled together, Polysarcia, the different chronic morbid enlargements of the viscera, Emphysema, Rickets, &c., and all from the single and indefinite character of tumefaction, being- common to them all. Sauvages goes even farther, and arranges retention of urine along with the dropsies. The class " Dolores," again, among the older nosolo- gists, afforded greater scope for still more inconsistent arrangements; and in later times we find Willan, from b2 XXIV INTRODUCTORY REMARKS. similar inaccuracy in adopting a fallacious criterion of distinction, congregating itch in the same order with small-pox. The principle, again, which Dr. Good adopted, relieved him from all observance of the affi- nities, either natural or pathological ; and when these do coincide with his arrangement, it is altogether attri- butable, as a matter of accident, to the essential nature of the function forming the class and order. It is thus that the arrangement of his Neurotica does not evince the same want of pathological connexion as we are compelled to observe in his classification of the diseases of the " Digestive Function," or among the multifarious and opposite diseases included in the affections of the " Sexual Function." The plan of the following Synopsis, differing as it does in so many respects from any other, has, as a matter of necessity, compelled the author to form and employ some new words, in a few instances ; but, in venturing to do so, he has striven to conform them with the spirit of the accepted nomenclature of the day, and to introduce as few of them as he possibly could. For the most part, the new terms are formed to denote the nature of the new arrangement, and are therefore con- fined principally to the more abstract terms, such as the names of orders, tribes, and genera ; and if, in one or two instances, he has presumed to change the name of a species, it has been solely for the sake of preserving a consistent uniformity, and only then where the term in use was either a solecism or an incorrect application of it with respect to its etymology, or to the pathologi- cal meaning it was employed to convey. No word is more frequently applied improperly by medical writers INTRODUCTORY REMARKS. than one in very ordinary use the word chronic. According to the meaning of its etymon (Agaves), it ought to imply, speaking of a disease, one that has lasted for some time ; for it is manifestly a solecism in language to say of any disease that it was chronic at its commencement ; and yet this is done every day. A person who is affected with one of the species of rheumatism, though it may be for the first time, is said to be attacked with chronic rheumatism. Now, though a disease may by persistence subside into a chronic state, it always begins either in an acute or sub-acute form ; and in the above instance, therefore, the disease is sub-acute rheumatism, not chronic. But this is not the only inaccuracy entering into the acceptation of the word chronic. When employed to denote the last stage of an acute disease, such as that state of debility of the veins remaining after acute conjunctivitis, the latter periods of a catarrh, or of gonorrho?a when the muculent discharge results more from relaxation than inflammation, that I conceive to be its proper applica- tion and meaning ; but the term is abused when it is employed to designate, what it often is, that state of re-excitement to which very many sub-acute inflamma- tions are liable : here, though the disease be of long- standing, its exacerbation cannot be considered of a chronic nature, but only a renewal of the sub-acute morbid action. The name of every disease ought to express, as per- fectly, and in as concise a manner as language will admit, both the nature of the disease and the exact seat of it. Thus the termination itis is now made by convention to denote inflammation ; and when this is XXvi INTRODUCTORY REMARKS. united with the name of the part inflamed, we have the disease accurately signified. It is from such a reason that the author has not hesitated to adopt several very useful words, especially those indicative of several ophthalmic diseases, as blepharitis, dachryo-cystitis, &c. from some of the best German writers ; and in one or two instances he has been induced to alter the nomen- clature, where this was egregiously improper, as in the case of gonorrhrea and haemorrhois, adapting the new term to the general model ; and, in another instance or two, the author has been obliged to form a new word altogether, from none being in existence designating the disease, such as the sub-acute inflammation which affects the tunica vaginalis lining the scrotum and co- vering the testis, the common sequela of which is hydro- cele. But as a general rule of observance, the writer has made it a point to interfere as little as possible with the nomenclature in use; for, though sensible that many names of diseases would not stand the strictest etymo- logical scrutiny in reference to their propriety as appo- site denominations, he is not the less persuaded of the impropriety of introducing any improvement in this respect in any other than the most gradual manner, and, as it were, verbatim. With respect to the signs employed as distinctions,, in the present Synopsis, a few words will suffice to explain their import : the numerals, as will be seen r denote the species, the Greek letters the different va- rieties of the species, and any of the varieties having sub-varieties, such as being epidemic, or having more forms than one, these are indicated by italic letters. The morbid consequences, again, or sequelae, primary INTRODUCTORY REMARKS. XXV11 and secondary, are distinguished after a similar man- ner. Thus, taking perichondritis, or inflammation of the perichondrium, as the species, we observe that there are two varieties of it simple perichondritis, such as may affect the cartilages of the ribs, and synovial peri- chondritis, or inflammation of the inter-articular peri- chondrium. Now this last has three sub-varieties, the syphilitic, the scorbutic, and the scrofulous ; while the varieties of the scrofulous, again, take their denomi- nation from the joints severally, as they may chance to form the seat of the morbid action. The manner in which these several diseases are denoted, the reader will find thus : Sp. PERICHONDRITIS. a. Simplex. /3. Synovialis. a. Syphilitica. b. Scorbutica. c. Scrofulosa. a. Coxendicis. b. Genu, &c, By " General Sequelae" it is intended to signify the secondary diseases common to all the varieties col- lectively ; but when a sequela immediately follows any particular variety, it simply denotes the secondary dis- ease belonging especially to that form, and not to the others that follow. There are diseases, again, that are subsidiary to the sequelae themselves, accruing, in fact, from them : these the reader will find indicated under the denomination of sub-sequelae. The sequelae, for example, of perichondritis are two ; first, absorption of XXVI11 INTRODUCTORY REMARKS. the substance of the cartilage,* by which it becomes thinner, but not ulcerated; and, secondly, ulceration of the cartilage, a common consequence or sub-sequela of which is anchylosis. Vicarious enuresis, in conse- quence of suppression of urine in nephritis, furnishes another example of a subsidiary sequela, where the urine is at times excreted from the skin, or it may be effused into the ventricles of the brain. For the sake of distinctness, the inflammations of the several tissues have been treated of separately ; but it must always be held in mind, that an inflammation commencing in one tissue is extremely apt to involve another, though of a different texture, if contiguous, in the same diseased action. For example, inflammation of the pleura covering the lungs is exceedingly liable to extend to their parenchymatous structure, thus forming pleuro-pneumonitis ; but in such a case the inflammations of the specific tissues have each their dis- * Some have been much inclined to doubt whether cartilage be an organised part of the body, simply from the circumstance that they have not been able to inject it, or to observe vessels in it when evidently diseased ; but both circumstances have little weight, in my judgment, as being conclusive against their vitality, when we give due consideration to the fact of their being not un- frequently partially absorbed without being ulcerated. To mea- sure the limits of vitality by size and vermilion, is graduating the powers of life by a biometer neither accurate nor applicable. Neither can we inject the cornea in its healthy state, or crystal- line lens, and yet disease can do both : so are they also capable of being absorbed, and of having matter (coagulate lymph) deposited within their structure. Is it necessary to ask, or to answer, how, and by what means these effects are accomplished'? Anatomy and pathology go hand in hand in reciprocally elucidating each other, and both must at times be received in evidence circumstantially. INTRODUCTORY REMARKS. XXIX tinctive symptoms ; and therefore, even when an inflam- mation extends its sphere of action into another tissue, we are enabled to detect it by the supervention of a new set of symptoms. The only exception, perhaps, to this law in pathology is when several distinct tissues are wounded by one and the same cause ; then the different sets of symptoms may be nearly simultaneous in their appearance : but this is a circumstance that does not affect the general law, neither can it well mis- lead us. These complications, therefore, are not spe- cially noticed in the following nosological arrangement. To conclude, the writer may be permitted to observe that it cannot be expected he should enter into a full development of so extensive a subject as the present, or elucidate views so important as those embraced by the outline he has barely sketched, in the narrow limits of an Introduction. Suffice it for the present to say, -that such constitute the principles on which his lectures are based. The subject has occupied his atten- tion and thoughts for years ; and he fain would hope, that the prosecution of it will tend to facilitate both the study and the satisfactory illustration of disease, by affording, to the student of medicine in particular, the means of acquiring a just idea of morbid affinities; and by thus associating diseases in a connected series of relations and sequences, a correct knowledge of them will be attained by simplifying the diversity of morbid actions, which otherwise only confuse the understanding by being unconnected! y subdivided, or discordantly grouped. CORRIGENDA. At page 4, insert as a sequela of " PHLOGOSIS CUTANEA" Absorptio ulcerativa (spontaneous excoriation), p. 5. After " suppuratio (apostemd). a. Ulcus," insert as another sequela, b. Synocha remittens (hectic fever), p. 15. After " TARSITIS," insert (psorophthalmia) as a sy- nonym, p. 25. After " PERITONITIS," insert as Sp. 10. VAGINO-TESTITIS. Inflammation of the tunica vaginalis of the testis and scrotum. Sequela. Hydrocele. p. 63. After " hemiplegica," insert as sequelae, a. Dysphagia paralytica. b. Incontinentia urinee. c. Dyspermatismus paralyticus. A NEW SYNOPSIS OF NOSOLOGY. Classis I. PHLOGOTICI. PURE inflammatory diseases. As the particular action constituting inflammation accom- panies, more or less, all the idiopathic fevers arising from miasms, this has induced the writer to commence his Synopsis with the class Phlogotici, in preference to that in which these fevers will be found arranged, and thus avoid the inconve- nience and incongruity of referring to morbid actions and results not previously classified. The morbid phenomena of inflammation appear to be deducible from the equilibrium of action in the circulation being destroyed between the heart and larger arterial trunks and their capillary extremities. In all local inflammations, when the affection is slight, and confined to an unimportant part, observation and experiments have demonstrated that the action of the extreme arteries and veins alone is unduly diminished, the main circulation remain- ing undisturbed. But when the attack is more violent, and the p'art or organ affected performs an office of consequence ia the system, the heart and larger arteries become involved in the morbid phenomena: their action is inordinately in- creased in power and frequency, and thus institutes the accompanying febrile symptoms. B 2 Cl. PHLOGOTICI. Ord. PYRECTICI. Ordo I. PYRECTICI. Fevers purely inflammatory. The rationale of the symptoms in this order of the Phlogo- tici differs from that in which the essential morbid phenomena of inflammatory action are more antithetic, and consist in a general idiopathic inflammatory action of the vascular system, without a local determination to any particular organ. Neither do they originate from any iniasm, either paludal or animal, having previously entered the blood. It is this latter circum- stance that essentially distinguishes the phlogotic or inflam- matory from the hematic or humoral fevers. Genus 1. CONTINENS. Of the continued type. Species 1. SYNOCHA (inflammatory fever). Varietas . Simplex. /3. Biliosa. y. Comitata. Symptomatic of some local inflammation. Sp. 2. EPHEMERA (diary fever). a,. Mitis. /3. Gravis. y. Sudans. Gen. II. REMITTENS. Of a remittent type. Sp. 1. SYNOCHA REMITTENS (hectic fever). This form of Synocha is always symptomatic. Ordo II. MEMBRANACEI. Membranous inflammations. Sub-Ordo A. TEGUMENTARII. Inflammations of the membranous tissues forming the tegumentary laminae. The French anatomists, Dutrochet and Gaultier, have demonstrated that the integuments consist of six distinct laminae : viz. the epidermis, the lamina cornea, the lamina colorata, the lamina albida, the corpus papillare (consisting of the rete vasculosum and the papillae proper), and the corion. Gen. EPIDERMICI. Sp. ICHTHYIASIS. 3 To these tissues, composing the tegumentary parts of the body, the author has added the subcutaneous cellular mem- brane. This tissue, by enveloping the entire body, may pro- perly be considered tegumentary under this view alone ; but, appropriating this arrangement still more strictly, we shall see, if we examine into them, that, in the laws of its morbid phenomena, the subcutaneous cellular membrane corresponds with those of the other tegumentary tissues. Each of these tissues is the more especial seat of specific kinds of cutaneous diseases. I have said " more especial seat," because in tissues so slender and so contiguous, deriving their particular sets of vessels from the same source, one can seldom be affected without involving, more or less, one or more of the others. But while such is the fact, we still see that law in the organic system observed, by which each particular tissue modifies and characterises the morbid phenomena. Tribus I. IDIOPATHICI. Of an idiopathic nature. Gen. I. EPIDERMICI. Inflammations affecting the lamina cornea. It is this lamina of the epidermic tissue which produces and reproduces the nails in man, the scales in fish and ser- pents, the horns in animals, and which is constantly repro- - ducing the epidermis itself. This lamina, in fact, becomes epidermis on losing its vitnlity when exposed to the atmo- sphere. The epithelium, which is but an introversion of the epidermis lining the entire of the primae viae, undergoes a similar change by long-continued eversion, as we sometimes see in prolapsus of the rectum, and of the inner surface of the uterus. Sp. 1. ICHTHYIASIS (Jish-skin disease). a. Simplex. ft. Cornea. Sp. 2. VERRUCA (a wart). Sp. 3. CALLUS. A thickening of any part of the epidermis from hard work, much walking, con- stant attrition, &c. Sp. 4. CLAVUS (a corn). Produced by pressure, embedding an indurated portion of the lamina cornea in the corion beneath. 4 Cl. PHLOGOTICI. Ord. MEMBRANACEI. Sub- Genus PILARIS. Affecting the hair. Sp. 1. PLICA POLONICA. An inflammatory disease affecting the sheath of the hair formed by the lamina cornea. Gen. II. VASCULOSUS. Seated in the blood-vessels of the rete vasculosum. The vessels forming the net-work over the corion do not properly belong to this memhrane, but merely pass through it ; and from the small quantity of tissue connecting them toge- ther, there is no sensible tumefaction when affected with in- flammation j neither does this web suppurate readily, if no other tissue be involved in the action. Sp. 1. PHLOGOSIS CUTANEA* (idiopathic inflam- mation of the skin). a. ab acribus. p. ab ictu insectse. */. ab ambustione.f J. a distensione subcutanea (e. g. ab anasarca). t. Vesicularis (accompanied with vesications). a. a solis calore. b. ab irritantibus. c. a combustura. Gen. III. CORIACEI. Diseases having their seat in the fibro-cellular tissue of the corion. Sub-Gen. A. PROPRITJS. Affecting the corion simply. The corion is a dense areolar web ; and the small degree of vitality it possesses, from its being sparingly supplied with blood-vessels, causes it to be readily chilled ; hence, also, the reason why it suppurates so slowly, and heals so reluctantly. Sp. 1. PERNIO (chilblain). * This affection is ordinarily denominated erythema ; a word which the writer proposes to confine to those sympathetic efflores- cences of the same tissue proceeding from an internal cause. t When accompanied at the same time with excoriation, this becomes a wound (vide Plagx). Gen. COUIACEI. Sp. SYCOSIS. 5 Sub-Gen. B. SEBACEI. Seated in the sebaceous fol- licles of the corion. Acutus. Sp. I. SYCOSIS. a., Menti. ft. Capillitii. Sub-acutus, Sp. 1. ACNA (stone-pock}. . Simplex. ft. Gutta rosea (car bunded face). Sub-Gen. C. AREOLARES. Primarily affecting the adipose cellular packets situated in the areolse of the corion. Sp. 1. FURUNCULUS. . Simplex (boil), ft. Anthrax (carbuncle). a. Comitatus. Symptomatic of the plague. Sub-Gen. D. CORIO-AREOLARES. Affecting both the corion and areolse, (whence the tubercles and thick- ening of the skin). Sp. 1. ELEPHANTIASIS. Gen. IV. SUBCUTANEI. Inflammations of the subcu- taneous cellular tissue. Superficialis. Sp. 1. PHLEGMON. . Communis. ft. Phimotica (phimosis). a. Incarcerans (prepuce irretractile). b. Strangulans (prepuce retracted behind the glans). Sequelge. a. Suppuratio (apostema). a. Ulcus. 6 Cl. PHLOGOTICI. Ord. MEMBRANACEI. b. Mortificatio. a. Imperfecta (gangrana). b. Absoluta (sphacelus). Prof undo,. Sp. 1. PHLEGMON SUBFASCIALIS. a. Communis. p. Paroaychica (whitlow}. Sequelae. a. Suppuratio difFusa. a. Ulceratio fasciarum, tendinumque. b. Apostema psoaticum. c. Sinus. . Fistula. Trib. II. SYMPATHETICI. Diseases affecting sympa- thetically the tegumentary tissues. Excepting the preceding affections of the skin, which are purely idiopathic, and those originating from infectious contact, all the other cutaneous diseases are sympathetic of some acrimony generated idiosyncratically, or otherwise, in the first passages ; and this, by irritating a particular tissue of the intestines, excites by sympathy the morbid phenomena we observe in the corresponding tissue of the skin. Gen. SQUAMOSI. Seated in the lamina cornea, and causing a continual re-production of the epidermis, which keeps separating either in deciduous exfolia- tions, or in branny scales. Sp. 1 . Lepra (leprosy). a. Vulgaris.* /3. Alphoides. y. Nigricans. Sp. 2. PSORIASIS (scaly tetter). ,. Guttata. ft. DifFusa. * The affection of the nails in this disease, independent of other circumstances, shews its seat to be in the lamina cornea. Gen. SQUAMOSI. Sp. PSORIASIS. 7 y. Gyrata. 3. Inveterata. 8. Labialis. . Ophthalmica. u. Scro tails. 9-. Prseputii. t. Palmaria. Sp. 3. PITYRIASIS. d. Capitis (dandrijf). ,3. Rubra. y. Versicolor. S. Nigra. The next lamina, the corpus mucosum, or lamina colorata, does not seem to be especially the seat of any sympathetic cutaneous affection. Gen. II. VESICULOSI. Inflammations of the lamina* albida, in which the extremities of the vessels pour out serosity in form of sub-epidermic vesicles. Sp. 1. POMPHOLYX. et. Benignus. ft. Diutinus. y. Solitarius. This disease is arranged by Willan under the order Bullae ; but, the writer thinks, without any sufficient necessity for establishing the order at all. The difference between vesicles and blebs is this, that in the former, the serosity, being poured out gradually, distends the cells of the vesicles with- out bursting their septa ; but in blebs, the effusion taking place more quickly, and in larger quantity, ruptures the cel- lular septa, and the fluid of many cellules comes to be con- tained in one cell or bulla. Both blebs and vesicles are often seen co-existent, and produced by the same causes. The ap- plication of cantharides affords a familiar example of this fact, in which the fluid from the bleb is evacuated at once by a * The laminae immediately above and below the corpus muco- sum were first pointed out by Cruikshank in a negro who had died of small-pox. 8 Cl. PHLOGOTICI. Ord. MEMBRANACEI. single puncture, whereas it requires several perforations com- pletely to evacuate that of a vesicle. As for the difference in size of the two, that is no sure pathological criterion of dis- tinction. Almost all authors now agree in doubting the exist- ence of any particular disease under the name of pemphigus ; it is therefore omitted in this synoptical arrangement. Sp. 2. APHTHA (the thrush), a.. Lactantium. ft. Adultorum. y. Anginosa. . Maligna. Sp. 3. HERPES. . Phlyctaenodes. /3. Zoster (the shingles), y. Circinatus (the ringworm). . Labialis. t. Prseputialis. . Iris. Sp. 4. RUPIA. . Simplex. /3. Prominens. y. Escharotica. Sp. 5. ECZEMA. . Spontaneum. /3. Mercuriale. y. a frigore. Sp. 6. MILIARIA. . Phlogotica. Supervening in febrile diseases ; the effect of improper stimulant diet and treat- ment, when producing profuse sweating. Sub-Gen. PUSTULOSI. Inflammations affecting the lamina albida, in which it seems probable the vessels of the papillary tissue participate,* forming a puru- lent vesicle (pustule). * The writer is inclined to attribute the purulent nature of the matter to this participation. Gen. VESICULOSI. Sp. IMPETIGO. 9 i The Pustulosi do not appear to the author to require to be ranked as a genus by themselves, but only as a sub-genus of the Vesiculosi, notwithstanding that Willan has drawn so marked a distinction between these two kinds of secretions. It is a mistaken notion to entertain, that the matter we call pus is secreted with the characters which distinguish it : the mat- ter of pus is colourless when first secreted even from an open ulcer, and it is only by a change which it afterwards under- goes, that it assumes the yellow and what is known as the purulent appearance. Van Swieten was the first to prove this by direct experiment. This distinguished physician care- fully wiped off the matter from the surface of a clean healthy ulcer, as fast as formed, with a piece of sponge, and found it, on examination, to be perfectly colourless : the same fact is still more readily observed on an extensive scald. Pustules, if examined in the first instance, will always be found to con- tain a colourless fluid, which becomes yellow only after a time, and as the pustules fill. Again, in the natural cow-pox, the eruption is a pustule ; in the inoculated, it is a vesicle. This circumstance evinces how nearly allied they are in indentity. Indeed, it may be observed, that in almost all the vesicular diseases, the fluid becomes opaque, or changes to a straw- colour, before the vesicle dries up. We therefore see, that the difference between pustules and vesicles is so slight as not to warrant any wide distinction between the diseases they cha- racterise in fact, that they are little more than modes of one another, pathologically considered. Sp. 1. IMPETIGO (humid tetter). a,. Figurata. /3. Sparsa. y. Erysipelatodes. $. Scabida. i. Rodens. Sp. 2. ECTHYMA. at,. Vulgare. /3. Infantile. y. Luridum. 5. Sequelosum. Ensuing in the cachectic state left after measles, small-pox, &c. Gen. III. EFFLORESCENTES. Inflammations of the rete vasculosum, shewing themselves in vivid cuta- neous efflorescences. 10 Cl. PHLOGOTICI. Ord. MEMBUANACEI. Sp. 1. ERYTHEMA. a. Fugax. . Erraticura. y. Marginatum. $. Papulatum. Extending to the cellular tissues of the papillae. t. Tuberculatum. Involving the sebaceous follicles. . Nodosum. Extending to the subcutaneous cellular tissue, accompanied with partial ef- fusions. Sp. 2. ROSEOLA. Involving the papillae, and thus causing the accompanying itching or tingling sensation. a.. JEstiva. /3. Autumnalis. y. Annulata. 2. Infantilis. Usually caused by dentition. . Comitata. Occasionally symptomatic of gout, fever, variola, and vaccinia. Gen. IV. PAPILLARES. Inflammations sympatheti- cally affecting the rete vasculosum and papillae. As anatomy often illustrates the difficult and nicer points of pathology, so does pathology sometimes elucidate, in like manner, the more minute parts of anatomy. As a beautiful example of the latter circumstance, I may here notice, that, though the papillae over the surface generally cannot he shewn in a healthy state of the skin, and their existence, therefore, is admitted more hy analogy than hy actual demonstration, yet when these bodies become the seat of disease, as in measles, strophulus, &c. their existence in almost every part of the skin is made both obvious and palpable. Sub-Gen. A. Peculiar to infants. Sp. 1. STROPHULUS. <*. Intertinctus (red-gum). ft. Albidus. y. Confertus (tooth-rash). $. Volaticus. . Candidus. Gen. PAPILLARES. Sp. LICHEN. 11 Sub-Gen. B. Affecting adults. Sp. 1. LICHEN. . Simplex. /3. Pilaris. y. Circumscriptus. 2. Agrius. i. Lividus. . Tropicus (the prickly heat). . Urticatus. Sp. 2. PRURIGO. Generalis. a.. Mitis. /3. Formicans. y. Senilis. Localis. . Podicis. /3. Pudendi. y. Scroti. 5. Praeputii. ; ,. . t. Urethralis. The local varieties of Prurigo sometimes originate from causes entirely idiopathic ; at other times they are purely sympathetic. The corion does not seem to he sympathetically obnoxious to disease proceeding from the primee vice ; hut it is liable to be involved in the inflammations of the subcutaneous cellular tissue. Gen. V. SUBCUTANEI. Sympathetic inflammatory af- fections principally seated in the serous vessels of the subcutaneous cellular membrane. Sp. 1. URTICARIA (nettle-rash). This disease con- sists of effusions of lymphoid serosity into detached portions of the cellular tissue immediately beneath the corion ; and which, by suddenly distending, and thus irritating, the papillae, causes the itching sensation so commonly attendant on wheals. *. Febrilis. 12 Cl. PHLOGOTICI. Ord. MEMBRANACEI. /3. Idiosyncratica. Sometimes induced by eat- ing mussels, mushrooms, &c. y. Evanida. J. Persians. t. Conferta. . Tuberosa. j. Larvata. Sp. 2. ERYSIPELAS (S. Anthony's fire). Erysipelas consists in an inflammatory affection of the serous vessels of the subcutaneous cellular membrane (whence proceeds the attendant anasarca), ex- tending through the corion to the rete vasculosum (whence the efflorescence), and sometimes to the vessels of the lamina albida (whence the occa- sional vesications).* a. Phlegmonodes. Sequela. Apostema sero-purulens. When the corion has been much involved in the inflamma- tory action, a thickening of this mem- brane is left, which is slow in discussing. (8. (Edematodes. a. Encephalicum. Affecting the cellular tissue of the pia mater. Sequela. Effusio serosa cerebralis. y. Malignum. Sequela. Ulceratio gangrsenosa. 3. Puerperarum (erysipelatous puerperal fever). Sequela. Effusio serosa abdominalis. * Erysipelas appears to partake of the nature both of the ex- anthems and the sympathetic cutaneous diseases. It is often ushered in by a precursory fever, and is at times infectious : it is also as frequently to be traced to some idiosyncratic or sympathetic affection of the primse vise. Gen. VESICULO-PUSTULARES. Sp. SCABIES: J3 t. Neonatorum. Affecting infants in lying-in hospitals. Sequela. Ulceratio gangrsenosa. Trib. III. CONTAGIOSI. Pustular cutaneous diseases not sympathetic, but produced by the absorption of a specific contagion, confining its action to the skin, and inducing eventually no constitutional symptoms or sequelae. Gen. I. VESICULO-PUSTULAKES. Appearing in the form of pustules or vesicles. The morbid action in this genus appears to be seated both in the rete vasculosum and lamina albida ; affecting likewise, in the first species, the nervous ramuscules of the papilla;. Sp. 1. SCABIES (the itch). at. Papuliformis. p. Lymphatica. Both scabies and impetigo exemplify that they may occa- sionally be either vesicular or pustular diseases, affording 'another proof and instance of the little essential difference there exists in any nosological distinction founded on such pathological characters. y. Purulenta. S. Cachectica. Sp. 2. PORRIGO (scald-head, #c.). x. Larvalis (crusta lactea). /3. Furfurans. y. Lupinosa. . Scutulata (ringworm of the scalp). i. Decalvans. . Favosa. 14 Cl. PHLOGOTICI. Ord. MEMBRANACEI. Sub-Ord. B. INTERNI. Inflammations of the internal membranous tissues. Although a doubt may attach to the precision of the ap- propriation of some of the diseases classed under the first sub- order of the Membranacei, or those affecting the external membranous or tegumentary tissues, this uncertainty, we shall find, in no way applies to any of the genera affecting the internal membranes. Gen. I. Mucosi. Inflammations of the mucous mem- brane. Bichat divides the mucous membranes into two systems the pneumo- gastric and the genito-urinary : the first, com- mencing at the mouth and nostrils, lines the air-passages and cells, and likewise the first passages ; the second begins at the meatus urinariusin the male, and after furnishing an inter- nal tunic to the urethra and bladder, ascends by the ureters and lines the cavities of the kidneys ; while in the female it commences at the vulva, and furnishes an inner tunic to the womb as well as to the bladder. Lining thus the great recep- tacles and emunctories of the body, these membranes are almost constantly in contact with extraneous or excre~ meutitious matters. This tissue, therefore, is to be regarded as a sort of sentinel stationed at the barriers of the interior of the system, to perform the same duty within which the skin discharges at its surface : both are emunctories, both are sur- faces of absorption, and both are tegumentary and protective. The peculiar nature and office of this tissue modifies its morbid affections. From the looseness of its texture there is little tension present when it is inflamed, neither is the pain very acute, -or the attendant fever very intense. Its most ordinary termination is an increase of its proper secretion (wmcus) ; and as the mucous membranes, both pneumo-gastric and genito-urinary, are to be regarded strictly as introversions of the cutaneous laminse, we find their diseased states both originating from, and influenced by, the condition and vicis- situdes of the atmosphere ; and hence, also, it is that several of them are of an epidemic nature. Sp. 1. CONJUNCTIVITIS. Inflammation of the con- junctival tunic of the eye.* * The conjunctiva, though covering the surface of the eye, must yet be reckoned one of the internal membranes, proceeding as it does from the inner lining of the palpebrae, and being covered by the eyelids. Gen. Mucpsi. Sp. CONJUNCTIVITIS. 15 Acuta. . Simplex. /3. Catarrhalis. y. Epidemica. 5. Herpetica (pustular ophthalmia, as it has been called). Sequelae. a. Depositio interstitialis. b. Ulceratio. Sub-acuta. . Encanthica. A partial, sub-acute inflam- mation affecting the inner canthic portion of the conjunctiva. Sequela. Pterygium. /3. Indolens (a blight). Sp. 2. BLEPHARITIS.* Inflammation of the inner lining of the palpebrae, attended with a copious puriform discharge. x. Simplex. /3. JUgyptiaca (Egyptian, or purulent oph- thalmia). a. Acuta. b. Sub-acuta. y. Virulenta. Produced by the contagious mat- ter of urethritis virulenta (gonorrhoea). 3. Neonatorum. Affecting new-born infants, caused by the contact of some discharge of an acrid nature in its passage through the vagina. General sequelae. a. Vegetationes granulares. b. Ectropium. c. Polypus palpebree. Sp. 3. TARSITIS. Inflammation of the Meibomian follicles of the tarsus. *. Universalis. Affecting the whole of the tarsus. * From /Sxi^agov, the eyelid. 16 Cl. PHLOGOTICI. Ord. MEMBRANACEI. a. Acuta. b. Chronica. c. Specifica. Proceeding from a scrofulous or syphilitic taint. Sequela. Entropium. Sub-sequela. Trichiasis. ft. Partialis. Confined to a single follicle (hor- deolum, sty). Sp. 4. DACHRYO-CYSTITIS.* Inflammation of the mucous lining of the lachrymal sac. Sequela. Fistula lachrymalis. Sp. 5. OTITIS. Inflammation of the mucous linings of the ear. . Externa. Affecting the ceruminous follicles of the external meatus. The follicles of the mucous tissues secrete, according to their particular situation, fluids differing in their qualities. In the ear, for example, cerumen ; in the skin, sebum ; in the tarsus, a glutinous mucosity ; in the stomach, some have be- lieved that they secrete the gastric juice ; and in the bronchi, intestines, &c. pure mucus. Sequelae. a. Secretio expers. When, from this cause, the remaining cerumen gets in- durated and impacted, a partial or total loss of hearing is a common result. b. Suppu ratio. c. Polypus meatus auditorii. ft. Interna. Inflammation of the mucous lining of the tympanum. Sequelae. a. Ulceratio. b. Caries. * From KU, a tear, and turns, a cyst or sack. Gen. Mucosi. Sp. OTITIS. 17 Sub-sequelee. a. Dysecoea. b. Cophosis organica. Sp. 6. MYCTERITIS* (coryza). Inflammation of the mucous membrane lining the nasal fossae. . Idiopathica. /3. Comitata. Symptomatic of measles, &c. Sequelae. 1 . Polypus narium. 2. Anosmia. Sp, 7. ANTRITIS. Inflammation of the mucous lin- ing of the antrum maxillare. This disease is most frequently occasioned by the irrita- tion of a carious tooth. Sequela. Abscessus antri. Sp. 8. FAUCITIS. Inflammation of the mucous lining of the fauces. English pathologists employ hut one name (cynanche ton- sillaris) to designate two inflammations of very different struc- tures, which, though frequently conjoined, exist not unfre- quently distinct 1 mean the inflammation of the mucous mem- brane covering the tonsils and fauces, and that of the tonsil itself. The author has separated them in this Synopsis, de- noting the one by the name offuucitis, the other by that of tonsittitis. a. Acuta. ft. Subacuta. y. Comitata. Accompanying several of the ex- anthems. Sequelae. 1. Ulceratio ccenosa (sloughing utcera- tiori). 2. Gangrsena. * From fAutcrn^tf, the nostrils. 18 Cl. PHLOGOTICI. Ord. MEMBRANACEI. Sp. 9. GLOSSITIS.* Inflammation of the mucous membrane and follicles of the tongue. . Acuta (idiopathica). p. Subacuta (symptomatica). This state of the tongue accompanies all febrile diseases, as well as most chronic visceral complaints, and is familiarly known by the name of" foul tongue." Sp. 10. PHARYNGITIS. Inflammation of the mu- cous lining of the pharynx. Sp. 11. CEsopHAGiTis. Inflammation of the mu- cous lining of the oesophagus. Sequelae. a. Polypus oesophagi. b. Strictura oesophagi. The parts most liable to this sequela are the cricoid, and cardiac portions. Sp. 12. LARYNGITIS. Inflammation of the mucous lining of the larynx. #. Catarrhalis (raucitas, a hoarseness). Sequelae. a. Dysphonia susurrans. b. Aphonia. /3. Pseudo-membranacea (laryngeal croup}. Characterised by the croupy cough : the two following varieties of croup are without this symptom. Sp. 13. TRACHEITIS. Inflammation of the mucous lining of the trachea. . Catarrhalis. /3. Pseudo-membranacea (tracheal croup). Sp. 14. BRONCHITIS. Inflammation of the lining membrane of the bronchi. . Propria. a. Sicca. b. * From y\uffftt, the tongue. Gen. Mucosi. Sp. BRONCHITIS. 19 Sequela. Phthisis ulcerosa. ft. Pseudo-membranacea (bronchial croup). y. Arthritica. Not an uncommon precursor and concomitant of gout. Sp. 15. CATARRHUS. General inflammation of the mucous membrane of the air-passages, extending into the cells of the lungs. . Vulgaris. ft. Epidemicus (the influenza). y. Senilis. ei. Intestinalis (diarrhoea mucosa). s. Comitatus. Symptomatic of measles, &c. Sp. 16. GASTRITIS. Inflammation of the mucous coat of the stomach. ,. Acuta. a. a causa externa proveniens. b. a causa intus proficiscens. ft. Sub-acuta (dyspepsia). Sequela. Carcinoma pylori. y. Comitata. Symptomatic, in an acute form, of typhus fever, &c. Sp. 17. ENTERITIS. Inflammation of the mucous tunic of the intestines. a. Duodeni (duodenitis), ft. Jejuni (jejunitis). y. Ilei* (ileitis). ^. Coli (colitis dysenteria). a. Acuta. b. Chronica. c. Epidemica. d. Complicata. Dysentery conjoined with typhus or intermittent fever, &c. * This variety is remarkable for the almost total absence of the pain ordinarily attendant on the other forms of enteritis. C 20 Cl. PHLOGOTICI. Ord. MEMBRANACEI. i. Recti (rectitis proctitis hcemorrhois*). a. Acuta. b. Chronica. . Comitata. Symptomatic, like gastritis, of typhus fever, certain of the exanthems, &c. Sequelae of rectitis, or inflammation of the mucous coat of the rectum : Of the Acute Hgemorrhagia. Of the Chronic a. Hsemorrhoea. b. Marisca. c. Fistula in ano. d. Strictura recti. General sequelae. a. Infiltratio. b. Ulceratio. c. Sphacelus. Sp. 18. CYSTITIS. Inflammation of the inner coat of the bladder. . Acuta. /8. Subacuta. y. Chronica (blennorrhcea vesicalis). $. Partialis. Confined to the cervix, and not unfrequently produced by the use of strong injections in urethritis virulenta (gonor- rhoea}, or by the irritation of a calculus. e. Traumatica. Ensuing after the operation of lithotomy, &c. * No name could well be more improper to designate inflam- mation of the inner tunic of the rectum than h&morrhois, since a flux of blood is not at all either an invariable or a necessary symp- tom. The discharge of blood, in the first instance, is usually the consequence of the strong efforts made to expel indurated fxces ; indeed, the force I speak of is very commonly the primary cause of the inflammation itself. When a disposition to inflammation and haemorrhage has thus been laid, by the repeated occurrence of the disease, the lower bowel will often inflame in consequence of a common cold ; and the hasmorrhage, from the same cause, will in time become both habitual and constitutional. Gen. Mucosi. Sp. METRITIS. 21 Sp. 19. METRITIS. Inflammation of the inner tunic of the womb. . Acuta. a. Puerperalis. /5. Subacuta. Sequela. Polypus uteri. y. Chronica (blennorrhcea uterina leucor- rhcea). Sp. 20. VAGINITIS. Inflammation of the mucous lining of the vagina and vulva. . Benigna. /3. Virulenta (gonorrhoea). y. Chronica (blennorrhcea vaginalis). Sp. 21. URETHRITIS. Inflammation of the mucous lining of the urethra. . Benigna. /3. Virulenta (gonorrhoea*}. y. Chronica (blennorrhcea^ urethralis, gleet}. Sequela. a. Strictura organica. a. Dyspermatismus. b. Dysuria. c. Ischuria retentionis. d. Fistula in perineo. Gen. II. SEROSI. Inflammations of the serous tissues. The serous membranes are of two kinds one firm in tex- ture, even, diaphanous, and elastic, as the pleura, perito- neum, &c. ; the other loose and cellular in structure, as the sack forming the chambers of the eye and covering the iris, the parietes of the cells of the cellular membrane, the lamina * The word " gonorrhoea," signifying, as it does, a flux of semen, is obviously an improper name to designate an inflamma- tion of the urethra of a virulent nature attended with a flux of mucns. t From /SXma, mucus, and piu/ri;, a flux. 22 Cl. PHLOGOTICI. Ord. MEMBRANACEI. albida of the cutis, &c. On the open surfaces of all, a lym- pboid serosity is being constantly poured out from the orifices of the exhalant arteries that terminate on their surface, which is as constantly being removed, in a state of health, by the absorbents. The first of these kinds, when inflamed, is at- tended with acute pain and fever ; the pulse varies in the different forms of this disease, being full and hard in pleuritis, small and sharp in peritonitis ; the skin is dry and parched, the symptoms rapid in their progress, and the disease at times characterised by insidious remissions. The morbid terminations of these inflammations, in their acute stage, are albuminous exudations and adhesions; purulent matter is often formed on their surface, or they may terminate iu gangrene ; and, in their chronic stage, they pour out serosity abounding in albumen, and hence readily coagulahle by heat.* Sp. 1. DURA-MENINGITIS (phrenitis^). Inflamma- tion of the serous lamina of the dura mater. Sequelae. a. EfFusio serosa. b. Suppuratio. Sp. 2. ARACHNITIS. Inflammation of the arach- noid membrane of the brain. . Idiopathica. /3. Sympathetica. Sympathetic of irritation of the chylopoietic and assistant-chylopoietic viscera. y. Idiosyncratica. Strumous arachnitis. 5. Comitata. Symptomatic of various fevers. i. Traumatica. Caused by external violence. Sequela. Hydrocephalus. Sp. 3. IRITIS. Inflammation of the serous mem- brane covering both sides of the iris, and lining the anterior and posterior chambers of the eye. " It is this circumstance which particularly distinguishes this effusion from that which is the consequence of dropsy. t This is obviously a very improper name for any disease ; since, according to the pathological meaning now attached to itis, it signifies inflammation of the mind. Gen, SEROSI. Sp. IRITIS. 23 <*. Acuta. ft. Subacuta. y. Symptomatica. Symptomatic of syphilis, scro- fula, &c. Sequelae. a. Depositio interstitialis. Changing the colour of the iris, or closing up the pupil. b. Adhsesio pupillse. a. ad lentem. i . , , , , lAbsoluta-- b. ad corneam. J> n ,. ,. , , \Partiahs. c. ad lentem et corneam. J Sub-sequela. Atrophia oculi. From abolition of the chambers. c. Hydrophthalmia. a. Staphyloma. From the internal pressure producing ulcerative absorption and protrusion of the cornea. d. Hypopyon (apostema of the cham- bers). e. Haemophthalmus (effusion of blood into the chambers'). Sp. 4. HYALOIDITIS. Inflammation of the hyaloid membrane of the eye. Sequela. Glaucoma. Sp. 5. CHOROIDITIS. Inflammation of the choroid tunic of the eye. The inflammation going on in the last two species is either subacute, or so obscure as only to be known by its effects. When universal ophthalmia, as it has been called, takes place that is, when every tissue is simultaneously affected with acute inflammation complete destruction of the organisation ensues, and the ball of the eye not unusually bursts, or staphyloma scleroticum is the consequence. c2 24 CY. PULOGOTICI. Ord. MEMBRANACEI. Sp. 6. LABYRINTHITIS. Inflammation of the serous membranes lining the labyrinth of the ear. Breschetbas lately demonstrated that there are two liquids in the labyrinth, contained in distinct sacs the liquor Cutugni, and another which he has named vitrine, upon the membrane containing which the auditory nerve expands. It is from this structure that this distinguished pathological anatomist draws a beautiful and ingenious parallel between the ear and the eye from analogy ; the membrana tympani answering to the cornea ; the cavity of the tympanum to the chambers of the eye ; the liquor Cotugni to the crystalline humour; and the vitrine to the vitreous humour. Sequelae. a. Hydrops labyrinthi. b. Depositio interstitialis. Causing thicken- ing of the membranes. c. Suppuratio. Destroying the organisation. a. Caries. b. Cophosis organica. Sp. 7. PLEURITIS. Inflammation of the pleura. <*. Costalis. Of the portion lining the thorax. ft. Pulmonalis. Of the part enclosing the lungs. y. Diaphragmatica. Of the part over the dia- phragm. ei. Pericardiaca. Of the outer tunic of the peri- cardium. Sequelae. a. Hydrothorax.* b. Adhaesiones pseudo-membranaceae. c. EfTusio purulenta. Sp. 8. PERICARDITIS. Inflammation of the internal serous membrane of the pericardium. * As there is a marked difference in the nature of the serous effusion occurring in consequence of acute inflammation and that which is poured out in cases of chronic visceral diseases, anaemia from heemorrhagy, &c., the author proposes to call, say, as ex- amples, the one bydrothorax, the other hydrops thoracis hydro- pericaidium, and hydrops pericardii, &c. Gen. SEROSI. Sp. PERICARDITIS. 25 . Propria. Of the inner lining. /3. Cardiaca. Of the part covering the heart. Sequelae. a. Hydropericardium. b. Adheesio ad cordem. a. Pseudo-membranacea. b. Absoluta. Sp. 9. PERITONITIS. Inflammation of the perito- neum. . Propria. Of the part lining the cavity of the abdomen. /3. Gastrica. Of that forming the outer tunic of the stomach. y. Enterica. Of that extended over the intes- tines. J. Epiploica. Of that spread over the omentum. . Mesenterica. Of its duplicature forming the mesentery. . Hepatica. Of that covering the liver. jj. Splenica. Of that covering the spleen. $-. Cystica. Of that forming the outer tunic of the bladder. i. Metrica. Of that spread over the womb. Sp. 10. ARTERITIS. Inflammation of the inner tunic of an artery. Sequelee. a. Dilatatio. b. Absorptio suppurativa. Sub-sequela. Aneurisma. c. Effusio lymphatica. Sub-sequela. Obliteratio tubee. Sp. 11. PHLEBITIS. Inflammation of the inner coat of a vein. . Brachii. Not unfrequently ensuing from bleeding with a foul lancet. 26 Cl. PHLOGOTICI. Ord. MEMBRANACEI. /3. Puerperarum. Occurring after delivery. a. Cruris* (phlegmasia dolens). b. Interna. Affecting the abdominal and thoracic veins. c. Ophthalmica. Attacking the veins of the eye, and quickly disorganising it. Sequela. Suppuratio interna sine ulceratione ve- narum. Gen. III. ALBUMITSTOSI. Inflammations of the albu- minous tissues. The substance of the cornea and lens consists of pure al- bumen, secreted in the former by the vessels of its outer tunic, and in the latter by those of its capsule. It is on this account that the author conceives be is justified in adding a new tissue to those already acknowledged by modern anatomists ; other- wise he would have found it impossible to have classed the diseases either of the cornea or lens, with any degree of pro- priety, among those of any of the other secreting membranes. Sp. 1. CORNEITIS. Inflammation of the cornea. . Tuniculse.f Confined to its outer tunic. /3. Propria. Affecting the cornea itself. Sequelae. , ' T \ (interstitial depositions). b. LeucomaJ v c. Onyx (abscess between the laminae). d. Absorptio suppurativa. Externa. Of its external surface. a. Ulcus corneae. * When the corion is much involved in the inflammation, it is frequently left much thickened. t Mr. Wallace of New York, in a letter to my friend Mr. Mackenzie of Glasgow, has shewn that the membrane covering the outer surface of the cornea is not an extension of the conjunc- tiva, but perfectly distinct from it. \ The author would here indicate the deposition which takes place into the tunicula of the cornea by the word nebula ; and by the term leucoma he proposes to designate that which occurs between the laminae of the cornea. The word albugo, again, might be made to denote a deposition or speck on the conjunctiva. Gen. ALBUMINOSI. Sp. CORNEITIS. 27 Interna. Of its substance. a. Staphyloma. a. Universale (protrusion of the entire cornea). b. Partiale (projecting only at the centre). b. Ruptura cornese. a. Staphyloma racemosum. Sp. 2. LENTITIS. Inflammation of the lens. ot,. Propria. Affecting the substance of the lens. Sequela. CsitaT:a.cta.\enticu\aris(interstitialdepositiori). /3. Capsularis. Affecting its capsule only. Sequela. Cataracta capsularis. Gen. IV. FIBROSI. Inflammations of the fibrous tissues. The fibrous tissues differ from the mucous and serous in being continuous. Taking the periosteum as the centre, we can trace them, without interruption, wherever else fibrous tissue is found. In departing from the bones, it is continued over the most external of the muscles in the form of fasciae and aponeuroses ; it is every where connected with the ten- dons, ligaments, and articular capsules ; it is produced from the under-side of the ischium into the corpus cavernosum of the penis ; it enters into the cranium at its base, through the different foramina, to form the introcranial periosteum or fibrous lamina of the dura mater, and sends down prolonga- tions to constitute the falx and tentorium, or stretching along the optic nerve, it expands itself on the globe of the eye to form the sclerotica. The vascularity of this tissue varies in different parts, vessels abounding in some, as the dura mater and periosteum, few in the aponeuroses, and not to be detected in the tendons : hence it is that diseases are more apt to occur in the two former than in the two latter structures. Another peculiarity of this tissue is, that in a healthy state it is perfectly insensible to any mechanical or chemical irritant ; but if unduly and suddenly stretched by the action of muscles, or by torsion, the pain experienced is intense : this we see in almost all luxations, in sprains, or when violent extension is made on c 3 28 Cl. PHLOGOTICI. Ord. MEMBRANACEI. the ligaments connecting the vertebrae. Extension made from within produces the same effect, as we see in the excruciating pain attendant on orchitis, caused by the inflam- mation distending on all sides the tunica albuginea and its septa. The morbid alterations of this tissue are few, and are de- ducible from the effusion ofcoagulable lymph. This causes thickenings of the different iibrous structures, and not unfre- quently cohesions one with another, or with other contiguous parts. Hence impediments to the free motions of joints (imperfect anchylosis), and to the free action of muscles con- nected with these adhesions, are the ordinary sequelae of fibrous inflammations. Sp. 1 . SCLEROTITIS. Inflammation of the sclerotic coat of the eye. a.. Idiopathica. p. Symptomatica. a. Rheumatica.* b. Scrofulosa. c. Syphilitica. d. Urethritica. Sequela. Staphyloma scleroticum. Sp. 2. RHEUMATISMUS. Inflammation of the fascial, aponeurotic, tendinous, ligamentary, and other fibrous structures. Most writers consider rheumatism to be a muscular dis- ease, deceived, as I conceive, by the pain produced by mo- tion ; but in this respect it is the different tendons, aponeu- roses, fasciae, and ligaments, that suffer by the action, and not the real muscular fibre. Whence else is it that the pain should be felt, in most instances, only about the articula- tions'? Where, again, is the muscular fibre to be found when this disease affects the sclerotic coat of the eye 1 Acutus. Accompanied with fever and tumefac- tion. * It is of practical importance to distinguish this variety of sclerotic inflammation from simple idiopatbic sclerotitis, as the two diseases yield to very different treatment. Gen. FIBROSI. Sp. RHETJMATISMUS. 29 . Articularis. Affecting principally the liga- ments of the joints, and the fasciae and tendons of the muscles connected with their movements. /3. Pericardiacus. Attacking the middle or fibrous coat of the pericardium and valves of the heart. This is usually a metastatic disease. Sub-acutus. Without fever or much sensible tume- faction. . Hemicranialis. Affecting the occipito-fron- talis and temporal aponeuroses; confined, for the most part, to one side of the head. p. Articularis. Like the acute, affecting chiefly the ligaments of the joints, and the ten- dons, fasciae, and aponeuroses of their muscles ; three of which have received specific names, viz. : a. Lumbago. b. Sciatica. c. Arthrosis. y. Tunicee albuginese testis. The author once met with a case of this singular form of rheumatism in a gentleman's gamekeeper. The pain was most excruciating, but ceased as soon as the disease shifted to the joints, leaving the testis without any accompanying or subsequent inflammation. 2. Urethriticus. In this form of rheumatism, as well as in urethritic scle- rotitis, I have repeatedly found stricture to exist in the membranous part of the urethra, which, becoming inflamed by the extension of gonorrhoeal inflammation, seemed to be the latent sympathetic cause of these two diseases. This is another beautiful illustration of the reciprocal sympathies of similar tissues: the membranous part of the urethra is a fibrous texture, as well as the sclerotic coat of the eye ; and rheumatism, we know, is confined in its action to the fibrous structures. I have often had occasion, also, to remark, that a stricture so situated, when inflamed or very irritable, is sure to be rendered more so by severe vicissitudes of the weather ; 30 Cl. PHLOGOTICI. Ord. MEMBRANACEI. and I may add, in conclusion, tbe fact, confirmatory of the opinion I have expressed of the origin of urethritic rheuma- tism, that curing the stricture is the only effectual means of curing the rheumatism ; without attending to which the dis- ease is extremely obstinate ; and when removed, it is exceed- ingly apt to return. General sequela. Depositio interstitial is. Producing thicken- ings and adhesions, and hence contrac- tions, and partial inflexibility of the joints (anchylosis imperfectd). Sp. 3. PODAGRA. Inflammation of a specific nature affecting the synovial structures, particularly of the smaller joints. The writer entertains a persuasion that this disease is connected with some peculiarity of sanguification, either hereditary or acquired, in which there are grounds for sus- picion, that urea, in some form or other, superabounds in the blood. Were this opinion ascertained, the disease would consequently require to be arranged among the Haemapoietici. . Regularis. Affecting the smaller joints, most frequently of the great toe. Sequelae. a. Depositio albuminosa. Impeding the free motion of the parts. b. Secretio et depositio calcis uratis (toft). Producing deformity and loss of ar- ticular power. /3. Larvata. This variety of gout, if it continues its form, not unfre- quently terminates in inducing a fatal apoplexy (hwrix.at t signifying the power of making. $ From u-ffi^, and aiftaraffis , sanguification. 58 Cl. NEUROTICI. Ord. ERGATICI. *. Tonica. Attended with a hypertonic state of the arterial system. Sequela. Inflammatory and hsemorrhagic diseases. ft. Atonica. Vital powers languid, pulse frequent and full, but feeble. Gen. II. HYPOHJEMATOSIS. Defective elaboration of blood. Sp. 1. ANAEMIA (emaciation). A. Inanitorum. ft. Famelicorum. y. Debilium. S. Dorsalis (tabes dorsalis). Sequela. Rachialgia Spermorrhoea. i. Symptomatica. The usual consequence of most chronic visceral diseases. General sequela. a. Hydrops. a. (Edema. b. Anasarca. c. Ascites. No dropsical affection is a purely primary disease : it is either a symptom or a sequela. Gen. III. CACOHTEMATOSIS. Cachectic elaboration of blood. Sp. 1. SCORBUTUS (scurvy). a.. Nautarum. Occurring at sea. ft. Asthenicus. Occurring in towns long besieged, &c. from a spare and unwholesome diet. Sp. 2. PURPURA (spontaneous ecchymosis). M. Simplex. ft. Haemorrhagica. y. Urticodes. 2. Symptomatica (petechice). From a putrid condition of the system, induced by disease. Gen. H^EMOSTASIS. Sp. MYCTERRHAGIA. 59 Trib. II. H&MACYCLICI.* Diseases of the circulation. Gen. I. H^MOSTASIS. f Sanguineous congestions from arterial determinations, or venous debility. ARTERIALIS. Attended with a phlogotic diathesis and hypertonic action of the arteries. Sub-Gen. A. HJEMOSTASIS EPIRRHOICA.J Afflux of blood to a part without sanguineous exhalation. None of the diseases of this sub-genus have received spe- cific names : a determination of blood to the head is one of the most common. Sub-Gen. B. H^EMOSTASIS H^EMORRHAGICA. Deter- mination of blood to a particular organ, with san- guineous exhalation from the arterial capillaries. As the word hgmorrhagia signifies, according to its deri. vation, a bursting out of blood, thus implying impetus or force, the author has limited its employment to denote the active sanguineous fluxes alone ; while, as hamorrhcea signi- fies a flowing of blood simply, and conveys no idea of force or impetus, so this word is used to designate the passive san- guineous fluxes. While endeavouring thus to denote the real pathological difference in the natures of these two morbid phenomena by their nomenclature simply, he has, at the same time, annexed a specific term indicative of the organ whence the blood issues. In the haemorrhagiae the efflux of blood is occasioned by the diathetic tonic action of the capillary arteries, producing sanguineous exhalation ; whereas, in the hasmorrhceae, the sanguineous flux ensues from the engorgement of the ca- pillary veins, produced by their inability to forward their contents. Sp. 1. MYCTERRHAGIA (epistaxis). Hsemorrhagy from the mucous membrane of the nostrils. . Idiopathica. /3. Symptomatica. * From at/tec, the blood, and KvxXas, a circuit. t From olfta, and g9 b. Interlobulare. a. Symptomaticum. y. Pleurae. a. Traumaticum. 2. Pericardii. a. Traumaticum. s. Tympaniticum (tympanitis), a. Abdominale. b. Intestinale. c. Traumaticum. d. Symptomaticum. Symptomatic of dys- pepsia, hysteria, &c. . Uteri (physometra, tympany of the womb). MatericB Calcarecs. Sp. 1. URALITHUS* (calculus, or the stone}, a.. Renalis. a. Arenosus (renal gravel). b. Calculosus (stone in the kidney}. Sequela. Nephritis calculosa. ft. Vesicalis. a. Arenosus (vesical gravel). b. Calculosus (stone in the bladder). Sequelse. a. Dysuria. b. Cystitis calculosa. Sp. 2. PHOSPHOLITHUS (ranuld). Deposition of a phospho-calcareous matter within a salivary duct. (Usually occurring under the tongue.) Materi& Sebacece. Sp. 1. ENCYSTIS.I Tumours formed by secretions of a morbid nature into the sebaceous follicles. <*. Steatoma. * From ovgav, urine, and X&ey , a stone. t From it, within, and xt/W<;, a sac or cyst. 70 Cl. NEUIIOTICI. Ord. EROATICI. /3. Atheroma. y. Meliceris. 5. Molluscum. These tumours diifer essentially from those fleshy forma- tions immediately to be classified, from being merely morbid alterations in the consistence and quality of the sebum, the sac of which is formed by the enlarged follicle itself ; whereas in the sarchexiae, the tumour is a new matter entirely, and the enveloping cyst formed of condensed cellular membrane. Trib. IV. ORECTICI.* Diseases of the appetites. Sub-Gen. I. HYPEKTONICI. In which the appetites are morbidly excessive. Sp. 1. BULIMIA (voracious appetite). . Helluonum. /3. Syncopalis. A constant craving for food as soon as the stomach is empty, accompanied with a fainting sensation. y. Canina. Insatiable appetite, followed by vo- miting shortly after being gratified. 5. Convalescentium. Attendant on convalescence after certain diseases, more especially fevers. I had an opportunity of witnessing this in a remarkable degree after the Walcheren fever. s. Symptomatica. Symptomatic of worms, &c. Sp. 2. SATYRIASIS. Unbridled desire for venery in the male. . Juvenilis. ft. Furens. y. Sympathetica. Excited by prurigo podicis. Sp. 3. NYMPHOMANIA. Immoderate desire for ve- nery in the female. . Salax. /3. Furibunda. * From O^K, the appetite. Gen. CACOPOIETICI. Sp. NYMPHOMANIA. 71 y. ab acribus. S. Sympathetica. Excited by prurigo pudendi, podicisve. The author has purposely excluded both Polydipsia and Adipsia from his nosological arrangement, seeing they are merely symptoms, and not diseases. Gen. II. ATONICI. In which the appetites are mor- bidly defective. Sp. 1. ANOREXIA (want of appetite). x. Idiopathica. From atony of the stomach. /3. Symptomatica. Symptomatic of general de- bility, palsy, all the cachexise, and of most acute diseases. Sp. 2. ANAPHRODISIA (defect of venereal desire). . Asthenica. Usually induced by previous ex- cesses. /3. Symptomatica. Symptomatic of palsy, &c. Gen. III. DIASTROPHICUS.* Depraved or perverted appetite. Sp. 1. PICA (a longing or craving). at,. Chlorotica. Attendant on chlorosis. /3. Prsegnantium. Affecting pregnant women.