_ U.S. Department of
nima Health and Human Services

Public Health Service

Resou rees National Institutes of Health

A Research Fifth Revised Edition
1983

Resources Directory

 

 

 

 

 

 
''Please refer all queries on this publication to:
Research Resources Information Center
1776 East Jefferson Street

Rockville, Maryland 20852

301/881-4150

or

Office of Science and Health Reports
Division of Research Resources
National Institutes of Health

Bethesda, Maryland 20205

301/496-5545
''A publication of: :
National Institutes of Health VE f
Bethesda, Maryland 20205 hiipk

Prepared by:
Research Resources Information Center
under contract NO1-RR-9-2114

 

Animal
Resources

A Research aes
. October 1983
Resources Directory

 

U.S. DEPARTMENT OF

HEALTH AND HUMAN SERVICES
Public Health Service

National Institutes of Health

NIH Publication No. 84-1431

 

Celebes macaques at Oregon
Regional Primate Research Center
provide models for a type of diabetes
mellitus that occurs in aging humans.
''Cap fer (Lh

(49 atp
PUBL
''Contents

Introduction
2

Purpose and Organization of the Directory
3

Directory of the Resources
4-46

Primate Research Centers
4

Animal Diagnostic Laboratories
13

Geographic Locations of Primate Research Centers
and Animal Diagnostic Laboratories — A Map
26

Animal Reference Centers
27

Special Animal Colonies and Model Studies
29

Primate Breeding and Resource Projects
35

Information Projects
41

Geographic Index
47
''Introduction

The Animal Resources Program of the NIH Divi-
sion of Research Resources helps meet the
need of biomedical researchers for high quality,
disease-free animals and specialized animal
research facilities. Today the program sup-
ports, via grants and contracts, primate re-
search centers and their field stations, primate
breeding and supply projects, development of
animal models, animal diagnostic laboratories,
and a variety of other animal research projects.

The program comprises two subprograms.
The Primate Research Centers Program sup-
ports seven primate research centers located
across the country, which annually provide over
700 biomedical scientists with specialized envi-
ronments for studying those human diseases
best investigated in nonhuman primates. The
Laboratory Animal Sciences Program improves
animal quality and availability through projects
that study the diseases and environmental re-
quirements of research animals, develops spe-
cific animal models and colonies with special
characteristics, upgrades laboratory animal fa-
cilities, and provides postdoctoral training in
laboratory animal medicine.

The purpose of this directory is to inform re-
searchers of the resources provided by the Ani-
mal Resources Program and where to access
them. Examples of the services and facilities
available at resource sites are: modern analyt-
ical laboratory equipment; surgery, X-ray, and
clinical pathology units; improved animal cages
and holding facilities; materials and techniques
for diagnosis of animal diseases; reference re-
agents and antisera; animal breeding stations,
notably those for nonhuman primates; and se-
lected invertebrate and vertebrate species, in-
cluding specific genetic strains and models in
development.
''Purpose and Organization of the Directory

This publication constitutes a complete revision
of the 1981 edition of the Animal Resources Di-
rectory prepared by the Research Resources
Information Center for the Division of Research
Resources (DRR), National Institutes of Health.
It is one of a series of directories of the special
research resource facilities and services sup-
ported by the DRR throughout the United
States. This new directory is a guide for scien-
tists seeking sources of assistance and collab-
oration involving animals in health research.

The directory entries are organized by type
of resource and, within each type, resources
are arranged alphabetically by title. Each entry
includes the name of the resource; the name,
address, and telephone number of the principal
investigator or resource director; research em-
phasis of the resource; and the services pro-
vided. A geographical index to these animal re-
sources is provided at the end of the directory.
It lists the resources alphabetically by state and
by title within each state and includes the
names of the cities in which they are located
and the page on which each resource entry
appears.
''Primate Research Center

 

 

Title of Resource: Center Director:
Center California Primate Research Center Charles E. Cornelius, DV.M., Ph.D.
and The center is located on a 300-acre tract, 3 California Primate Research Center
Center miles from the main campus of the University of University of California, Davis
: California, Davis. The university administers the Davis, California 95616
Director center and provides its academic setting. (916) 752-0420
Principal Investigator:
Edward A. Rhode, DM.M., Ph.D.
Dean, School of Veterinary Medicine
University of California, Davis
Emphases @ Basic Research Mission: Studies of adverse @ Primate Resources:
of Core effects of the environment on human health; Primate medicine: Maintenance of colony
Research use [cian animal models in biomedical re- health, programs in preventive medicine;
Units searcn. research services such as surgery, radiol-
Current Research ogy, medical procedures, and consultation;
@ Experimental Biology and Medicine: Mecha- domestic breeding; research on spontane-
nisms responsible for jaundice, acquired auto- ous diseases.
immune deficiency, fetal and neonatal immunol- Primate pathology: Monitoring and defining
ogy, and diabetic retinopathy. health problems; research on spontaneous
@ Perinatal Biology and Reproduction: Normal diseases.
and abnormal aspects of prenatal develop- @ Contact Person: Charles E. Cornelius, DV.M.,
ment, with particular emphasis on embryotoxic Ph.D., director, (916) 752-0420; or Andrew G.
effects of certain agents administered during Hendrickx, Ph.D., associate director of re-
pregnancy; primate biobehavioral response search, (916) 752-3045.
and adaptation to the environment on the indi-
vidual, group, and social system levels.
@ Respiratory Diseases: Effects of air pollutants
and disease on the respiratory system; lung
growth and aging; pulmonary immunopath-
ology.
Resources To Outside Investigators —Electron Microscopy: Scanning and
Provided @ Specimens Available: Organs and tissues transmission electron microscopy.

are provided when available; other biological

samples are provided on special request.

Costs of shipping, collection, and processing

are charged to the requestor.

To Collaborating Scientists

e Eligibility: Scientists wishing to conduct re-

search at the center must have their projects

reviewed and approved by the center director

and scientific advisory committee.

e Services: The center's services are available

to collaborating scientists, some on a fee basis

and some without charge. These include:
—Primate Medicine: Preventive medicine
and epidemiologic evaluation; surgery; ra-
diology; therapeutics; specialized medical
procedures.
—Diagnostic Pathology and Clinical Labo-
ratory Services: Bacteriology, biochemistry,
hematology, immunology, parasitology,
pathology, virology.

—Data Services: Colony data-base sys-

tem.

—Animals:
Center Breeding Colony: Macaca fascicularis,
M. mulatta, M. radiata, Papio anubis, P. cyno-
cephalus, Saimiri sciureus.
Center Research Colony: Callicebus moloch,
M. mulatta, M. radiata, Papio anubis, P. cyno-
cephalus, Saimiri sciureus.
''Primate Research Center

 

 

Title of Resource: Center Director:
Center Delta Regional Primate Research Center Peter J. Gerone, Sc.D.
and The center is located on 500 acres near Cov- Delta Regional Primate Research Center
Center ington, Louisiana, 35 miles from the main Tu- Three Rivers Road
: lane University campus in New Orleans. Tulane Covington, Louisiana 70433
Director University administers the center and provides (504) 892-2040 x 201
its academic setting.
Principal Investigator:
John J. Walsh, M.D.
Chancellor
Tulane University Medical Center
Emphases e Basic Research Mission: Infectious diseases, © Parasitology: Biology of filarial infections;
of Core neurobiology, and biochemical research. parasitic diseases of nonhuman primates.
Research Current Research e Urology: Pyelonephritis; cystitis; chronic
Units @ Microbiology: Testing of antiviral compounds; prostatitis and benign prostatic hyperplasia;
experimental infections using Mycobacterium male fertility.
leprae, herpesviruses, cytomegaloviruses, par- @ Contact Person: Center director or Robert H.
voviruses, rotaviruses, coxsackieviruses, and Wolf, DV.M., chief, Veterinary Sciences Depart-
parainfluenza and simian viruses; molecular vi- ment, (504) 892-2040.
rology and basic immunology of infectious dis-
eases and cancer.
e Biochemistry: Glycosidases as related to
sphingolipidoses; glycosidase involvement in
degradation of complex carbohydrates.
e Neurobiology: Neurological effects of pre-
natal radiation and aging; motion sickness
studies.
Resources To Outside Investigators —Pathology: Necropsies, histopathology,
Provided @ Specimens Available: Tissue specimens, or- clinical pathology, bacteriology, hematol-

gans, etc., are provided when available. Costs
are normally assumed by the individual re-
questing the specimens.
To Collaborating Scientists
@ Eligibility: Scientists wishing to conduct re-
search at the center must have their projects
reviewed and approved by the center director,
scientific advisory committee, and the care and
use committee if experimental animals are in-
volved.
@ Services: The center's services are provided
to collaborating scientists on varying bases.
Some are provided without charge, some on a
fee basis. They include:
—Animal Care: General veterinary care of
experimental animals; technical assistance
for procedures involving animals; hus-
bandry and breeding of nonhuman pri-
mates; nursery, surgery, and X-ray ser-
vices.

ogy, Clinical chemistry, electron micros-
copy.

—Parasitology Services.

—Radiation Facility: Cobalt-60 radiation
source.

—Science Information Service: Includes
MEDLINE, SDLINE, CATLINE, and
CANCERLINE.

—Medical Illustrations.

—Animals: Macaca mulatta, M. fascicu-
laris, M. arctoides, Erythrocebus patas,
Aotus trivirgatus, Saimiri sciureus, Pan
troglodytes, Cercopithecus aethiops, Cer-
cocebus atys atys, Papio spp.
''Primate Research Center

 

 

Title of Resource: Center Director:
Center New England Regional Primate Research Ronald D. Hunt, DV.M.
and Center New England Regional Primate Research
Center The center is located on 140 acres in South- Center a
: borough, Massachusetts, some 30 miles from One Pine Hill Drive
Director Boston. Harvard University administers the Southborough, Massachusetts 01772
center and provides its academic setting. (617) 481-0400
Principal Investigator:
Daniel C. Tosteson, M.D.
Dean, Harvard Medical School
Emphases e Basic Research Mission: Infectious diseases, @ Reproductive Biology: Genealogical data
of Core immunology, oncogenic herpesviruses, primate and control of inbreeding; environmental and
Research pathology, behavioral biology, cardiovascular nutritional enhancement of captive breeding
2 diseases, and nutrition. and rearing; production of nonhuman primate
Units Current Research twins; cryopreservation of ova, sperm, and pre-
@ Microbiology: Oncogenic herpesvirus in pri- implantation embryos.
mates; therapeutic approaches to herpesvirus- © Immunology: Spontaneous immunosuppres-
induced lymphoma in owl monkeys. sion: characterization and causes; bone mar-
© Comparative Pathology: Spontaneous dis- row chimerism.
immunodeficiency syndrome; hemolytic anemia lar diseases, nutritional requirements of non-
of owl monkeys; cytomegalovirus-related dis- human primates.
eases of macaques; chronic colitis in marmo- @ Contact Person: Ronald D. Hunt, DV.M., cen-
sets; gastroenteric and neurologic diseases of ter director; or N. W. King, Jr, DV.M., director of
macaques. collaborative research, (617) 481-0400.
@ Behavioral Biology: Behavioral factors in car-
diovascular diseases; specialized research in
hypertension; central control of distribution of
organ blood flow; behavior sequences con-
trolled by drug injection.
Resources To Outside Investigators veterinary hospital, central sterilization and
Provided e@ Specimens: Tissue specimens, organs, cage washing.

blood, skeletal structures, viral specimens, etc.;
animals for approved research provided when
available. Costs are normally assumed by the
individual requesting the specimens.

To Collaborating Scientists

e Eligibility: Scientists wishing to conduct re-
search at the center must have projects re-
viewed and approved by the center director,
executive committee, and scientific advisory
committee. A brochure explaining the collabo-
rative research program is available from the
center.

@ Services: The center's services are available
to collaborating scientists on varying bases.
Some are provided without charge, some on a
fee basis. They include:
—Primate Medicine: Veterinary services,
routine and experimental surgical and
roentgenology services, primate nursery,

—Comparative Pathology: Necropsies,
computerized data retrieval system.
—Microbiology: \solation of viral and bac-
terial agents.

—FPathobiology: Electron microscopy; cy-
togenetics; biochemical analyses of vari-
ous body fluids are performed by collabo-
rators; biostatics.

—Animals: Macaca arctoides, M. cyclopis,
M. mulatta, M. fascicularis, Aotus trivirga-
tus, Saimiri sciureus, Saguinus Oedipus.
Animals with exceptional characteristics
(specially conditioned, exact age, surgi-
cally altered, timed pregnancy, specific ge-
netic characteristics) may be provided
when available.
''Primate Research Center

 

Title of

 

 

Resource: Center Director:
Center Oregon Regional Primate Research Center B. Vaughn Critchlow, Ph.D.
and The center is located on a 230-acre tract at Oregon Regional Primate Research Center
Center Beaverton, Oregon, 12 miles from Portland. The 505 NW. 185th Avenue
; Medical Research Foundation of Oregon ad- Beaverton, Oregon 97006
Director ministers the center and the Oregon Health Sci- (503) 645-1141
ences University provides its academic setting.
Principal Investigator:
Leonard Laster, M.D.
President
Oregon Health Sciences University
Emphases @ Basic Research Mission: Reproductive biol- gallstones in squirrel monkeys; spontaneous di-
of Core ogy and behavior; metabolic and immune dis- abetes and vascular sclerosis in nonhuman pri-
Research eases, mates; human and animal models related to the
. Current Research regulation of antibody synthesis; antirhesus
Units e@ Reproductive Biology and Behavior: Endocri- lymphocyte antibody in suppressing graft re-
nological control of ovulation; factors that con- jection; regulation of immune response by mac-
trol sperm motility; neuroendocrinology; hormo- rophages; melanoma immunology; melaniza-
nal control of parturition; steroid receptors in tion enzymes; role of cyclic AMP in mouse
primate reproductive tract tissues; fetal endo- melanoma.
crinology; placental circulation; smooth and @ Contact Person: B. Vaughn Critchlow, Ph.D.,
skeletal muscle metabolism; physiologic and center director, (503) 645-1141; Harold G.
social factors controlling sexual behavior; re- Spies, Ph.D., associate director for research,
productive behavior and hormones in aging (503) 645-1141.
rhesus monkeys; interaction of the immune and
reproductive systems.
@ Metabolic and Immune Diseases: Therapeu-
tic modification of coronary atherosclerosis; li-
poproteins and atherosclerosis; cholesterol
Resources To Outside Investigators —Pathology: Necropsies, tissue distribu-
Provided @ Specimens Available: Tissue specimens, or- tion, consultation.

gans, etc., are provided when available. Costs
are normally assumed by the individual re-
questing the specimens.

To Collaborating Scientists

e Eligibility: Scientists wishing to conduct re-
search at the center must have their projects
reviewed and approved by the animal care and
assignment committee and the associate direc-
tor for research. A brochure explaining oppor-
tunities for research and training is available
from the center.
e Services: The center's services are available
to collaborating scientists on varying bases.
Some are provided without charge, some on a
fee basis. They include:
—Medical Services: Physiological data
and surgical specimens; cardiology; re-
covery of animals for future projects.
—Radiology: X-rays and interpretation for
animal maintenance, breeding, surgery,
and research projects.
—Colony Operations: Primates, guinea
pigs, mice, hamsters, rats, rabbits.

—Electron Microscopy: Scanning and
transmission electron microscopes.

—Data Processing: Prime 550 computer
with remote terminals; comprehensive ani-
mal information system; consultation and
support on statistical processing; exten-
sive radioimmunoassay support.

—Library: 4,900 books, 9,400 bound jour-
nals, 230 journal subscriptions, MEDLARS
searching services.

—Radioimmunoassay Laboratory: Steroid
and pituitary protein hormone RIA.

—Medical Illustrations and Photography.

—Animals: Galago crassicaudatus, Lemur
fulvus, L. catta, Macaca fascicularis, M.
nigra, M. fuscata, M. nemestrina, M. mu-
latta, Papio anubis, Saimiri sciureus, Ce-
bus albifrons. Includes a large, naturally
occurring troop (over 250) of M. fuscata for
studies in behavior and 800 M. mulatta in
outdoor breeding corrals.
''Primate Research Center

 

 

Title of Resource: Center Director:
Center Regional Primate Research Center at the Orville A. Smith, Ph.D.
and University of Washington Regional Primate Research Center
Cent The center is located in the Warren G. Magnu- |-421 Health Sciences SJ-50
enter son Health Sciences Center of the University of University of Washington
Director Washington in Seattle. Seattle, Washington 98195
(206) 543-1430
Principal Investigator:
Vice-President for Health Sciences
University of Washington
Emphases @ Basic Research Mission: Biomedical re- — @ Cardiovascular Disease and Function: Arte-
of Core search on primates, with special emphasis in rial smooth muscle cell in atherosclerosis; eval-
Research developmental biology, neurological sciences, uating blood-compatible biomaterials; mecha-
: cardiovascular function, disease models, endo- nisms of arterial graft failure; prosthesis for
Units crinology and metabolism, and immunogenetics. aortocoronary bypass; fetal hemoglobin syn-
Current Research thesis.
Core Staff: Primate models of neuropsychiatric @ Disease Models: Methylmercury embryopa-
disorders; primate neuroanatomy; functional re- thy; patterns of ethanol ingestion; venereal dis-
lations between precentral cells and muscle; ease research; experimental allergic encepha-
vestibular and oculomotor interactions; aging in lomyelitis, endometriosis; aplastic anemia.
primates; metabolism of polyunsaturated fatty @ Endocrinology and Metabolism Research:
acids; developmental psychology; central neu- Reproductive physiology; regulation of gluca-
ral control of cardiovascular system. gon; oviductal transport; hypothalamic regula-
Affiliated Staff: tion of metabolic substances; role of somato-
statin in physiology and control of somatostatin
@ Developmental Biology: Respiratory dist’ess Secretion, CNS regulation of fuel mobilization
mate vocalization. and storage; diabetes endocrine research.
@ Neurological Sciences: Structure and devel- Contact Person: Orville A. Smith, Ph.D., center
opment of monkey visual cortex; auditory phys- director, (206) 543-1430.
iology; retinal development.
Resources To Outside Investigators e Services: The center's services are made
Provided e Specimens: Tissue specimens, organs, etc., available to collaborating scientists on varying

are provided when available. Charges for tis-
sues and shipping costs are assumed by the
individual requesting the specimens.

@ Primate Information Center: Bibliographic in-
formation on biomedical research of nonhuman
primates is compiled. Data collations, topical
and current awareness bibliographies (Current
Primate References) are also published.

@ Primate Supply Information Clearinghouse: A
matching service for primates and tissues
available and needed in the United States is
provided, published in the weekly Primate Sup-
ply Bulletin. A registry of primate colonies and
special services is being developed.

To Collaborating Scientists

@ Eligibility: Scientists wishing to conduct re-
search at the center must have their projects
reviewed and approved by the center director
and executive committee and be appointed by
the administrative board.

bases. Some are provided without charge,
some on a fee basis. They include:
—Pathology: Necropsies.
—Central Services: Scientific illustration
and editing; research histology laboratory.
—Primate Colony Division: Primate health
care, surgical procedures, X-ray, electron
microscopy, Clinical laboratory, primate
nursery.
—Bioengineering: Instrumentation devel-
opment, computer programming, animal
records system.
—Animals: Macaca fascicularis, M.
mulatta, M. nemestrina, Papio cynocephalus.

Continued on next page
''Primate Research Center

 

 

 

Resources
Provided

—Collections: 110 timed-gestation (known-
age) M. nemestrina fetuses with X-rays and
anthropometric measurements; 50 abnor-
mal M. nemestrina fetuses: teratogens,
abortions, stillbirths; 2,000 dental casts on
200 M. nemestrina; slides of lung develop-
ment in fetal, known-age M. nemestrina;
development data on 400 macaque infants
including anthropometric measurements,
heart rates, respirations, body tempera-
tures, diurnal activities, fluid intakes, and
weight gains; social behavior develop-
mental data on 500 macaque infants 1 to 7
months old; videotapes of labor and deliv-
ery of 100 M. nemestrina; learning assess-
ment data on 100 M. nemestrina infants;
computerized historical data on 6,500 ani-
mals including 70,000 weights, 22,000
breeding records, 21,000 hematologies,
13,500 disease and necropsy records; and
15 brains from M. fascicularis prepared
histologically.
''Primate Research Center

 

 

Title of Resource: Center Director:
Center Wisconsin Regional Primate Research Robert W. Goy, Ph.D.
and Center Wisconsin Regional Primate Research Center
Center The center occupies a four-story, 30,000- 1223 Capitol Court
. square-foot building on the University of Madison, Wisconsin 53715-1299
Director Wisconsin-Madison campus as well as space (608) 263-3500
in three nearby annexes. In addition, the center a
maintains a 5,000-square-foot breeding re- Principal Investigator:
search facility at the Vilas Park Zoo in another Robert M. Bock, Ph.D.
part of the city. The university administers the Dean
center and provides its academic setting. Graduate School
University of Wisconsin
Emphases @ Basic Research Mission: Primate behavior, ulation and reduction of aggression and ten-
of Core reproduction, and neurosciences. sions in primate groups.
Research Current Research @ Behavioral Endocrinology: Endocrinological
Units @ Reproductive Physiology: Hormonal control regulation of reproductive and social behavior
of implantation and maintenance of pregnancy; in monkeys and rodents; social and experimen-
factors regulating development of ovarian folli- tal factors that modify hormonal influences;
cles; mechanisms involved in initiation of pu- studies of the interaction of social and hormo-
berty; role of the corpus luteum in late preg- nal factors that mediate the development and
nancy; in vitro fertilization in nonhuman expression of individual differences in the dis-
primates. play of sexual and aggressive behavior in rhe-
@ Neurochemistry: Effects of female sex hor- Sus monkeys,
mones on brain chemistry and behavior. . aoe nee oan eee typing for de-
® Gonadotropic Physiology: Developmental eHTINahel OF PAC (GS BNC CiReaSe
changes in the synthesis and release of pitui- associated phenotypes. /
tary hormones related to reproduction. e Experimental Pathology: Structural studies of
Neurophysiology: Control mechanisms of go- the pituitary-hypothalamic axis and of sensory
nadotropin secretion, especially the role of the and autonomic nerves in primates.
hypothalamus and limbic structures in repro- e Primate Ecology: Survey and census of pri-
ductive cycles. mates in Cameroon, West Central Africa.
@ Aging: Changes in hormonal and nervous e Feeding Behavior: Identification of variables
systems associated with aging in nonhuman that influence feeding behavior and body
primates. weight regulation in the rhesus.
@ Behavior of Group-Living Primates: Social s Contact Person: Robert W. Goy, Ph.D., center
behavior, especially behaviors serving the reg- director, (608) 263-3500.
Resources To Outside Investigators —Bioservices: Clinical laboratory tests, in-
Provided © Specimens: Tissue specimens, organs, and cluding assay procedures for adrenal,

10

other biological materials are provided when
available. Costs are normally assumed by the
individual requesting the specimens.

To Collaborating Scientists

@ Eligibility: The center actively encourages
researchers from the midwest region to use its
facilities and services and to conduct collabo-
rative studies. Scientists wishing to conduct
research at the center must have projects re-
viewed and approved by the center director
and research review committee and must have
independent funding to cover costs of the re-
search.

e Services: The center's services are available
to collaborating scientists on varying bases.
Some are provided without charge, some on a
fee (chargeback) basis. They include:

gonadal, and pituitary hormones; surgery;
breeding colony; baseline data service on
reproductive behavior.

—Colony Management: Maintenance and
veterinary medicine; assistance in drug
administration, specimen collection, and
animal handling.

—Computer Services: Colony record sys-
tem and research data processing.
—Photomedia: Art and photographic ser-
vices.

—Library: 5,500 books, 9,500 volumes of
journals, 200 active journal subscriptions.
—Animals: Macaca mulatta (over 1,000),
M. nemestrina. The center maintains a
breeding colony that produces nearly 200
rhesus infants a year.
''Primate Research Center

 

Title of
Center
and
Center
Director

Resource:

Yerkes Regional Primate Research Center
Center facilities include the main building on
the Emory University campus in Atlanta, a
117-acre field research station in nearby
Lawrenceville, and a language research center
in Panthersville, Georgia.

Center Director:

Frederick A. King, Ph:D.

Yerkes Regional Primate Research Center
Emory University

Atlanta, Georgia 30322

(404) 329-7707

Principal Investigator:

Orie E. Myers, Jr., M.S.
Vice President for Business
Emory University

Atlanta, Georgia 30322
(404) 329-6009

 

Emphases
of Core
Research
Units

e@ Basic Research Mission: Neurobiology, be-
havior, pathology and immunology, and repro-
ductive biology.

Current Research

e@ Neuroanatomy: Light- and electron-
microscopic analysis of the organization of sen-
sory and information processing systems, in-
cluding vision, olfaction, spinal cord, and
hypothalamus.

e Neurophysiology: Sensory electrophysiology,
including unit activity, with emphasis on the vis-
ual system. Hypothalamic control and hormone
correlates of aggressive, sexual, and other
social behaviors. Development of remote-
controlled bioinstrumentation to measure hor-
mones.

@ Neuroendocrinology: Relationship of brain to
endocrine activity in motivated behaviors. Ra-
dioimmunological analysis of neuroendocrine
mechanisms controlling pituitary hormone se-
cretion, reproductive cycles, and sexual behav-
ior. Studies of endorphins, opiate receptors,
and neuropeptides.

e@ Behavioral Biology: Environmental and social
determinants of behavior; physiological re-
sponse to drugs of abuse and effects of these
drugs on conditioned behavior and social or-
ganization; relationship between aggressive
and sexual behaviors and levels of naturally oc-
curring hormones; language acquisition in
chimpanzees, and application of methods and
findings to human learning of language and
mental retardation; great ape sexual behavior
and its regulation by hormones; psychobiologi-
cal development of infant great apes; and
maternal-infant relationships.

e Pathobiology: Breeding and measurement of
biological values in rhesus monkeys for space
research; long-term biological effects of irradia-
tion; identification and development of animal
models for human diseases; experimental tera-
tology of oral-facial malformations; epidemiol-
ogy of neoplasia; infectious and parasitic dis-
eases in primates; relationship between
infection, amyloidosis, and reactive arthritis.
Continued on next page

 

Resources
Provided

To Outside Investigators

e@ Specimens Available: Tissue and organ

specimens and body fluids from great apes

and monkeys are provided when available.

Preparation and shipping costs are paid by

recipient.

To Collaborating Scientists

e Eligibility: Research proposals are submitted

to center director and reviewed by director and

scientific review committee.

e Services: The following services are available

at cost to core and collaborating scientists:
—Veterinary Medicine: Health mainte-
nance, clinical diagnosis, radiology, and
medical and surgical treatment.
—Pathology: Routine laboratory diagnostic
procedures, microbial cultures, necropsy,
histopathology, cytogenetics, and diagnos-
tic electron microscopy.

—Immunology: Profiles of lymphocyte
membrane antigens on apes and Old
World monkey cells. Cells and pedigrees
from selected higher ape families.

—In vitro bioassay for LH, and radiorecep-
tor bioassays for prolactin and growth hor-
mones.

—Radioimmunoassays: For glycoproteins
(FSH and LH), polypeptides (prolactin,
growth hormone, and insulin), steroids
(cortisol), LHRH, and oxytocin. Analyses
being developed for the following peptides
and hormones: vasopressin, 17 beta-
estradiol, beta-endorphin, progesterone,
and testosterone.

—Transmission and scanning electron
microscopy.

Continued on next page

11
''Primate Research Center

 

Emphases
of Core
Research
Units

@ /mmunobiology: Investigations of human
tissue-specific and tumor-associated antigens
to establish phylogenetic changes in apes.
These studies include isolation and characteri-
zation of human antigens defined by chimpan-
zee antisera; modification of cell hybridization
techniques to human systems; and definition
and characterization of antigens detected by
nonhuman primate antisera to leukemia and
melanoma cells and to carcinoembryonic anti-
gen and gross breast cystic fluid protein.

@ Reproductive Biology: Development of a non-
human primate model for in vitro fertilization;
studies of cervical mucus composition and its
role in fertility control; sperm membrane physi-
ology related to fertility; endocrine studies of
adrenarche, puberty, and reproductive cycles;
control of pituitary function by catecholamines
and endorphins; regulatory actions of ACTH in

primate reproduction; artificial insemination and
breeding of the great apes; treatment of physi-
ologic impotency; and effects of diet on estro-
gen biosynthesis and metabolism.

@ Contact Persons: Frederick A. King, Ph.D.,
center director, (404) 329-7707; or Harold M.
McClure, D.V.M., associate director for scien-
tific programs, (404) 329-7742.

 

Resources
Provided

12

—Biomedical Engineering: Research in-
strumentation development; bioelectronics;
computer facilities and services.

—Shop: Fabrication and/or maintenance of
test equipment; specialized caging and
components.

—High-Pressure Liquid Chromatography.
—Medical Illustration and Photography.
—Information Services: Includes library.

—Animals: Pan troglodytes, Pan paniscus,
Pongo pygmaeus, Gorilla gorilla, Hylo-
bates lar, Macaca mulatta, M. radiata, M.
nigra, M. nemestrina, M. arctoides, M. fas-
cicularis, Cercocebus atys, Saimiri sciu-
reus.
''Animal Diagnostic Laboratory

 

 

 

Title of Resource: Principal Investigator:
Center Animal Diagnostic and Investigative Gerald L. Van Hoosier, D.V.M.
and Laboratory School of Medicine SB-42
University of Washington
Center Seattle, Washington 98195
Director (206) 543-8047
Coprincipal Investigator:
Ronald F. DiGiacomo, V.M.D., M.P.H.
Resources @ Diagnostic Services: This laboratory is
Provided staffed to provide general competence in
gross, light-, and electron-microscopic pathol-
ogy, microbiology, parasitology, clinical chem-
istry, and hematology. Diagnostic resources
are designed primarily to serve the grantee and
affiliated institutions. However, with approval by
the principal investigator, they are available for
collaboration in investigating laboratory animal
disease problems.
@ Contact Person: Ronald F. DiGiacomo,
V.M.D., M.P.H., (206) 543-8047.
Research e Basic Objectives: To maintain the quality of
Emphasis or research animals through control and diagnosis
Application of disease within research animal facilities at

the University of Washington and affiliated insti-
tutions. To recognize and define abnormal
physiologic conditions and comparative dis-
eases that may be of interest to biomedical re-
searchers.

@ Current Research: Use of immunohisto-
chemical, fluorescent, and ELISA techniques
for more rapid diagnosis of viral infections of ro-
dents; pasteurellosis and syphilis of rabbits; an-
imal models of aging; naturally occurring dis-
eases of nonhuman primates.

13
''Animal Diagnostic Laboratory

 

 

 

Title of Resource: Principal Investigator:
Center Animal Disease Diagnostic and Investigative Patrick J. Manning, D.V.M.
and Laboratory Research Animal Resource
P.O. Box 351
Center Mayo Memorial Building
Director Health Sciences Center
420 Delaware Avenue, S.E.
University of Minnesota
Minneapolis, Minnesota 55455
(612) 376-5097
Resources e@ Diagnostic Services: This laboratory is
Provided staffed to provide general competence in gross
and microscopic pathology, microbiology, par-
asitology, clinical chemistry, hematology, and
selected serology. Diagnostic resources are
designed primarily to serve the grantee and af-
filiated institutions. However, when approved
by the principal investigator, they are available
for collaboration in investigating laboratory ani-
mal disease problems.
@ Contact Person: Patrick J. Manning, D.V.M.,
(612) 376-5097.
Research e@ Current Research: Pasteurellosis of rabbits
Emphasis or with emphasis on the roles of bacterial cell wall
Application lipopolysaccharides as a diagnostic antigen
and immunogen. Pathogenesis of experimen-

14

tally induced gastric bezoars in laboratory rab-
bits. Prevention and treatment of gastric tricho-
bezoars of rabbits. Effect of Mycoplasma
pulmonis infection on immune-mediated experi-
mental arthritis of rats.
''Animal Diagnostic Laboratory

Principal Investigator:

Steven P. Pakes, D.V.M., Ph.D.

University of Texas

Health Science Center at Dallas
5323 Harry Hines Boulevard
Dallas, Texas 75235

(214) 688-3340

 

Title of Resource:

Center Animal Resources Diagnostic and

and Investigative Laboratory

Center

Director

Resources @ Diagnostic Services: This laboratory is
Provided staffed to provide general competence in gross

and microscopic pathology, microbiology,
parasitology, clinical chemistry, and hematol-
ogy. Diagnostic resources are designed pri-
marily to serve the grantee and affiliated institu-
tions. However, with approval by the principal
investigator, they are available for collaboration
in investigating laboratory animal disease
problems.

e@ Contact Person: Steven P. Pakes, D.V.M.,
Ph.D., (214) 688-3340.

 

Research e Basic Objectives: To maintain the quality of
Emphasis or research animals through control and diagnosis
Application of diseases within research animal facilities at

the University of Texas. To recognize and de-
fine abnormal physiologic conditions and com-
parative diseases that may be of interest to bio-
medical researchers.

e Current Research: Pathogenesis, control,
and prevention of murine mycoplasmosis;
pathogenesis, control, and prevention of rabbit
pasteurellosis; chemotherapeutic and immuno-
therapeutic studies of feline leukemia; genetic
susceptibility and resistance to infectious
agents; genetic and environmental influences
on hypertension.

15
''Animal Diagnostic Laboratory

 

 

Title of Resource: Principal Investigator:
Center Animal Resource Support for Biomedical John D. Strandberg, D.V.M., Ph.D.
and Research Johns Hopkins University
Center 720 Rutland Avenue
. Baltimore, Maryland 21205
Director (301) 955-3273
Resources @ Diagnostic Services: This laboratory is
Provided staffed to provide general competence in gross
and microscopic pathology, microbiology,
parasitology, clinical chemistry, and hematol-
ogy in support of animal research and related
clinical problems. Diagnostic resources are de-
signed primarily to serve the grantee and affili-
ated institutions. However, with approval by the
principal investigator, they are available for col-
laboration in investigating laboratory animal
disease problems.
@ Contact Persons: John D. Strandberg,
D.V.M., Ph.D., (301) 955-3273, or Robert J.
Adams, D.V.M., (301) 955-3273.
Research @ Basic Objectives: To maintain the quality of primates; inherited deficiency of the third com-
Emphasis or research animals through prevention, control, ponent of complement in dogs; antibiotic thera-
Application and diagnosis of diseases within animal re- peutic regimens in laboratory rodents; modifi-
Pp search facilities at the Johns Hopkins University cation of urinary bladder carcinogenesis and

16

and Medical Institutions and their affiliates. To
recognize and define abnormal conditions and
diseases of medical interest and use to bio-
medical researchers.

e@ Current Research: Effects of aging on the
central nervous system of nonhuman primates;
investigation of animal models of neurologic
diseases such as hereditary spinal atrophy and
cerebellar ataxia; effects of vasoocclusive de-
vices in swine and dogs; etiology and patho-
genesis of enteric infections of rats and rabbits:
epizootic diarrhea of infant mice and other ani-
mal rotaviruses; retroviral infections of sheep
and goats as “slow’” viral diseases; canine be-
nign prostatic hyperplasia; hematologic altera-
tions accompanying chemical restraint in

leukemogenesis in rodents by retinoids; evalua-
tion of animal and in vitro models for carcino-
genesis risk assessment; a spontaneous model
of mitral valve prolapse in rhesus monkeys; in-
sulin pump implants in diabetic dogs; lympho-
proliferative disease in nonhuman primates re-
ceiving cyclosporin A.
''Animal Diagnostic Laboratory

 

Title of
Center
and
Center
Director

Resource:
Diagnostic Research and Clinical Laboratory
Program

Principal Investigator:

Dennis M. Stark, D.V.M., Ph.D.
Laboratory Animal Research Center
Box 2, Rockefeller University

1230 York Avenue

New York, New York 10021

(212) 570-8535

 

Resources
Provided

@ Diagnostic Services: This laboratory, in con-
sort with Cornell University Medical College,
Sloan-Kettering Institute, and the Animal Med-
ical Center, provides a complete laboratory ani-
mal diagnostic program. The Rockefeller Uni-
versity laboratory is specifically staffed to
provide expertise in microbiology, serology,
virus isolation, pathology, and parasitology. The
laboratory primarily serves the grantee and af-
filiated institutions. Collaborative diagnostic and
research programs related to laboratory animal
science are encouraged with other institutions.

e@ Contact Person: D. M. Stark, D.V.M., Ph.D.,
(212) 570-8535.

 

Research
Emphasis or
Application

e Basic Objectives: To provide diagnostic ser-
vices, prospective and retrospective research
studies in conjunction with disease screening,
sanitization, and diagnostics at Rockefeller Uni-
versity.

@ Current Research: Nonspecific immune en-
hancement studies involving a broad selection
of laboratory animals; development of rapid im-
munodiagnostic assays, post-surgical infection
studies, and clinical case reviews.

17
''Animal Diagnostic Laboratory

Principal Investigator:

C. Max Lang, D.V.M.

Milton S. Hershey Medical Center
Pennsylvania State University
500 University Drive

Hershey, Pennsylvania 17033
(717) 534-8462

 

 

Title of Resource:

Center Laboratory Animal Diagnostic Resource

and

Center

Director

Resources @ Diagnostic Services: This laboratory is

Provided staffed to provide general competence in gross
and microscopic pathology, microbiology, virol-
ogy, immunology, parasitology, clinical chemis-
try, and hematology. Diagnostic resources are
designed primarily to serve the grantee and af-
filiated institutions. However, with approval by
the principal investigator, they are available for
collaboration in investigating laboratory animal
disease problems.
@ Contact Person: C. Max Lang, D.V.M., (717)
534-8462.

Research @ Basic Objectives: To maintain the quality of

j research animals through control and diagnosis
Application. of diseases within the Animal Resource Facility
of Pennsylvania State University. To recognize
and define abnormal physiologic conditions
and comparative diseases that may be of inter-
est to biomedical researchers.
@ Current Research: Effects of acidified water
on immunosuppressed animals; the guinea pig
as an animal model for pregnancy toxemia; en-
vironmental effects of hepatic microsomal en-
zymes; role of Kilham rat virus in respiratory
disease.

18
''Animal Diagnostic Laboratory

ST Ran ga FETT ESS EOE RT SSO A POETS DEE A ES ES

 

 

Title of Resource: Principal Investigator:
Center Laboratory Animal Resource for Biomedical Henry J. Baker, D.V.M.
and Research University of Alabama in Birmingham
Cent University Station
enter Birmingham, Alabama 35294
Director (205) 934-2117
Resources e@ Diagnostic Services: This laboratory is e@ Other Services: Information about new ani-
Provided staffed to provide general competence in gross mal models of human diseases (see Current
and microscopic pathology, microbiology, Research). The resource is also interested in
parasitology, clinical chemistry, and hematol- having other animal models referred to it for fur-
ogy, and has special expertise in mycoplasma ther investigation or development.
infections of rodents. Diagnostic resources are e Contact Person: Henry J. Baker, D.V.M.,
designed primarily to serve the grantee and af- (205) 934-2117.
filiated institutions. However, with approval by
the principal investigator, they are available for
collaboration in investigating laboratory animal
disease problems.
Research e@ Basic Objectives: To improve the quality of @ Current Research: Definition of the patho-
Emphasis or animal research at the University of Alabama in genesis of, and development of improved
Application Birmingham through a sound professional pro- methods for diagnosis and control of, myco-
pp gram of clinical laboratory animal medicine/ani-

mal health evaluation/disease control. To iden-
tify and characterize animal diseases that are
useful models of human disorders. To charac-
terize spontaneous diseases of laboratory ani-
mals and improve methods to detect and con-
trol those diseases that complicate biomedical
research. To provide educational and training
programs in animal experimentation for veteri-
narians training in laboratory animal medicine/
comparative pathology, graduate students in
the biomedical sciences, veterinary students,
and biomedical research technicians.

plasma infections in rodents; discovery, char-
acterization, and maintenance of animal mod-
els of lysosomal storage disease; definition of
the long-term effects of Sendai virus infection of
rats and mice; elucidation of the mechanism of
chronic nephropathy and other diseases com-
plicating the use of rats in research on aging.

19
''Animal Diagnostic Laboratory

SES SL aS TE PEC AVY DLS RE

 

 

Title of Resource: Principal Investigator:
Center Laboratory for Marine Animal Health Charles G. Rickard, Ph.D.
and New York State College of Veterinary Medicine
C-111 Schurman Hall
Center Cornell University
Director Ithaca, New York 14853
(607) 256-5454 X2731
Resources @ Diagnostic Services: This facility in the Ma-
Provided rine Biological Laboratory provides such diag-
nostic services as clinical examinations, pathol-
ogy, microbiology, and epidemiology for a
broad spectrum of marine animals, including
many species of vertebrates and invertebrates.
®@ Contact Person: Dr. Louis Leibovitz, Labora-
tory for Marine Animal Health, Marine Biological
Laboratory, Woods Hole, Massachusetts
02543; (617) 548-3705, X513.
Research e@ Basic Objectives: The research community
j at Woods Hole—including the Marine Biolog-
ponienioo ‘ ical Laboratory, the Woods Hole Oceano-

20

graphic Institution, the National Marine Fisher-
ies Service Laboratory, and others—is pro-
vided with diagnostic assistance and research
collaboration involving many marine species
maintained in research facilities. Several spe-
cies of invertebrates are raised in confined col-
onies, with the goal of developing standardized
laboratory animals.

@ Current Research: Specific diseases in
laboratory-maintained squid (Loligo pealei),
Limulus polyphemus, toadfish (Opsanus tau),
Aplysia, Hermissenda, Capitella, and other
species are in progress. A highly fatal eugle-
noid infection of larval Aplysia californica was
investigated and characterized. Several para-
sitic and bacterial diseases have been identi-
fied and control measures evaluated.
''Animal Diagnostic Laboratory

 

Title of
Center
and
Center
Director

Resource:
Research Animal Diagnostic and
Investigative Laboratory

Principal Investigator:

Joseph E. Wagner, D.V.M., Ph.D.

Research Animal Diagnostic and Investigative
Laboratory

College of Veterinary Medicine

University of Missouri

Columbia, Missouri 65211

(314) 882-681 1

 

Resources
Provided

@ Diagnostic Services: This laboratory is
staffed to provide general competence in gross
and microscopic pathology, microbiology,
parasitology, rodent serology, and genetic
monitoring. Diagnostic resources are designed
primarily to serve the grantee and affiliated in-
stitutions as well as regional users of animals in
human health-related research. Faculty mem-
bers are available for collaboration in investi-
gating laboratory animal disease problems.

® Contact Persons: Joseph E. Wagner, D.V.M.,
Ph.D.; Earl K. Steffen, Ph.D., (314) 882-6811; or
Cynthia Kendall, Ph.D., (314) 882-6811.

 

Research
Emphasis or
Application

@ Basic Objectives: To aid in maintaining the
quality of research animals through control and
diagnosis of diseases within research animal
facilities of the four campuses of the University
of Missouri located in Columbia, St. Louis, Kan-
sas City, and Rolla, Missouri, and other regional
medical research facilities. To recognize and
define abnormal physiologic conditions and
comparative diseases that may be of interest to
biomedical researchers.

@ Current Research: Cytauxzoonosis in cats;
Mycoplasma spp. from rodents; factor XI!
(Hageman) deficiency in cats; intestinal micro-
flora of laboratory animals; applied research on
diagnosis methods, automated data handling;
Salmonella and Pseudomonas infections of ro-
dents; development of ELISA technology for the
agents of Tyzzer's disease (Bacillus piliformis),
Mycobacterium spp., Mycoplasma spp., Sal-
monella spp., Pseudomonas spp; and murine
viruses.

21
''Animal Diagnostic Laboratory

 

Title of
Center
and
Center
Director

Resource:
Research Animal Diagnostic Laboratory

Principal Investigator:

James G. Fox, DV.M.

Massachusetts Institute of Technology
77 Massachusetts Avenue
Cambridge, Massachusetts 02139
(617) 253-1757

Coprincipal Investigator:
James C. Murphy, DV.M., Ph.D.

 

Resources
Provided

e Diagnostic Services: This laboratory is
staffed to provide general competence in gross
and microscopic pathology, microbiology, para-
sitology, clinical chemistry, hematology, and di-
agnostic virology. Diagnostic resources are
designed primarily to serve the grantee and af-
filiated institutions. However, with approval by
the principal investigator, they are available for
collaboration in investigating laboratory animal
disease problems.

@ Contact Person: James G. Fox, DV.M., (617)
253-1757.

 

Research
Emphasis or
Application

22

e@ Basic Objectives: To maintain the quality of
research animals through control and diagnosis
of diseases within research animal facilities at
the Massachusetts Institute of Technology and
other animal research facilities in the greater
Boston area. To recognize and define abnormal
physiologic conditions and comparative dis-
eases that may be of interest to biomedical
researchers.

e@ Current Research: Salmonellosis in cats and
clinical manifestations of the disease in animals
stressed by experimental procedures; the
study of cytomegalovirus-associated insulitis in
diabetic Octodon degus and normative biol-
ogy; epidemiologic studies of Corynebacterium
kutscheri infection in laboratory rats; develop-
ment of ELISA techniques for bacteriologic and
virologic monitoring of rodent colonies; study of
amyloid-induced nephrotic syndrome in labora-
tory rodents; Campylobacter spp. and their role
in enteric disease in laboratory animals; study
of nosocomial outbreaks in veterinary and ani-

mal research environments; development of ef-
fective measures to promote safety and ade-
quate decontamination of the general animal
facility environment when animals are dosed
with extremely potent, toxic, and/or carcino-
genic compounds; evaluation of xenobiotic
contamination, including heavy metals, nitros-
amines, and aflatoxins, in laboratory animal
feeds; pathogenesis of Campylobacteriosis in
man and animals; isolation and characterization
of Campylobacter jejuni toxin(s); role of Cam-
pylobacter jejuni in proliferative bowel disease;
role of clostridial toxins in development of mu-
coid enteropathy in rabbits; pathogenesis and
serologic diagnosis of Corynebacterium kut-
scheri infection in laboratory rats; evaluation of
murine detection of cytomegalovirus antibody
using serological techniques; pathogenesis of
Chlamydia psittaci in poikilotherms; role of
smooth muscle cells in autoimmune vasculitis.
''Animal Diagnostic Laboratory

Title of Resource:
Center Resource for the Study of Laboratory
and Animal Diseases

Center
Director

Principal Investigator:

Robert O. Jacoby, DV.M., Ph.D.
Yale University School of Medicine
375 Congress Avenue

New Haven, Connecticut 06510
(203) 785-2525

 

Resources @ Diagnostic Services: This laboratory is

Provided staffed to provide general competence in
gross, microscopic, and ultrastructural pathol-
ogy, microbiology, parasitology, clinical chemis-
try, and hematology and has special expertise
in viral diseases of rodents. Diagnostic re-
sources are designed primarily to serve the
grantee and affiliated institutions. However, with
approval by the principal investigator, they are
available for collaboration in investigating labo-
ratory animal disease problems.

® Contact Person: Robert O. Jacoby, DV.M.,
Ph.D., (203) 785-2525.

 

Research @ Basic Objectives: To maintain the quality of
Emphasis or research animals through control and diagnosis
Application of diseases within animal research facilities at

pp the Yale University School of Medicine. To rec-
ognize and define abnormal physiologic condi-
tions and diseases that may be of interest to
biomedical researchers.

@ Current Research: Cell receptors for canine
distemper virus; improved serological methods
for detection of murine viral infections; patho-
biology of mousepox, Sendai viral pneumonia,
mouse hepatitis, and rodent parvovirus infec-
tions; genetic factors controlling resistance and
susceptibility to Sendai viral pneumonia; nu-
cleic acid hybridization probes to detect per-
sistent viral infection in rodents; immunosup-
pression induced by murine viruses; canine
model for hypercalcemia of malignancy.

23
''Animal Diagnostic Laboratory

 

 

Title of Resource: Principal Investigator:
Center Resource for the Study of Nonhuman Christopher Jerome, B. Vet. Med.
and Primates Wake Forest University
Bowman Gray School of Medicine

Center Winston-Salem, North Carolina 27103
Director (919) 748-4567
Resources @ Diagnostic Services: Diagnosis and study of
Provided nonhuman primate disease with special em-

phasis on metabolic and degenerative disor-

ders. Information and possible collaboration on

nonhuman primates. The resource staff is inter-

ested in obtaining nonhuman primates to es-

tablish colonies with such disorders as hyper-

tension and diabetes mellitus. Referrals of

primates with congenital heart defects, “failure

to thrive,” dyslipoproteinemia, or obesity are

welcomed.

® Contact Person: B. C. Bullock, DV.M., (919)

748-4567.
Research @ Basic Objective: To find and characterize dis-
Emphasis or ease entities of nonhuman primates that may
Application be useful in biomedical research.

24

@ Current Research: Investigation of diseases
of nonhuman primates, screening of Macaca
fascicularis and Cercopithecus aethiops for di-
abetes mellitus. Metabolic bone disease.
''Animal Diagnostic Laboratory

 

 

Title of Resource: Principal Investigator:
Center University Resource in Laboratory Animal Bennett J. Cohen, DV.M., Ph.D.
and Medicine 010 Animal Research Facility
University of Michigan
Center Ann Arbor, Michigan 48109
Director (313) 764-0277 /0278
Coprincipal Investigator:
Daniel H. Ringler, DV.M., M.S.
Resources @ Diagnostic Services: Necropsy examination,
Provided histopathology, clinical pathology, parasitology,
and bacteriology of laboratory animals. The
laboratory has special expertise in pathology of
aged rats and mice, pasteurellosis in rabbits,
and diseases of amphibians. Diagnostic re-
sources are designed primarily to serve the
grantee and affiliated institutions. However, with
approval by the principal investigator, they are
available for collaboration in investigating labo-
ratory animal disease problems.
© Contact Persons: Bennett J. Cohen, DV.M.,
Ph.D., or Clarence E. Chrisp, DV.M. (313)
764-0277 /0278.
Research @ Basic Objectives: To maintain and improve dures such as an enzyme-linked immunosor-
Emphasis or the quality of laboratory animals through con- bent assay (ELISA) for pasteurellosis in rabbits;
Application trol and diagnosis of diseases in the animal recognition and definition of animal models of
colonies at the University of Michigan and affili- human disease such as herpesvirus, keratitis,

ated institutions. To conduct research in labora-
tory animal and experimental medicine. To en-
hance research training in laboratory animal
medicine.

e Current Research: Investigation and charac-
terization of spontaneous and iatrogenic dis-
eases of laboratory animals, including study of
basic mechanisms of disease caused by such
laboratory animal pathogens as Pasteurella
multocida; prevention of pasteurellosis by vac-
cination; development of new diagnostic proce-

and encephalitis; definition of the spectrum of
spontaneous degenerative and neoplastic age-
associated lesions in SPF strains or stocks of
mice and rats.

25
''Geographic Locations of Primate Research Centers
and Animal Diagnostic Laboratories

 

@ Primate Research Centers
4 Animal Diagnostic Laboratories

26
''Animal Reference Center

ee

Principal Investigator:
Larry E. Mobraaten, Ph.D.
Staff Scientist

The Jackson Laboratory
Bar Harbor, Maine 04609
(207) 288-3371 X235

 

Title of Resource:

Center Cryopreservation of Murine Germplasm
and

Center

Director

Resources @ Reference Services: The repository contains
Provided frozen 8-cell mouse embryos from genetically

defined strains of laboratory mice that are

maintained at the Jackson Laboratory. Embryos

from over 250 different strains are currently
preserved. Breeding pairs of mice are made
available when such mice cannot be obtained
from conventional breeding sources.

e Contact Person: L. E. Mobraaten, Ph.D.,
(207) 288-3371, X235.

 

Research e Basic Objectives: To assure the safe preser-

Emphasis or vation of scientifically valuable strains of labora-

tory mice by establishing a bank of frozen
mouse embryos. At present the program staff
is freezing and storing in liquid nitrogen em-
bryos from selected strains of the more than
700 inbred and mutant strains of mice main-
tained at the Jackson Laboratory. Other objec-
tives are to reduce the necessary number of
different stocks or size of colonies maintained
by conventional breeding procedures and to
retard genetic drift.

e Current Research: Freezing of mouse em-

Application

bryos and recovery of liveborn from frozen em-

bryo storage.

27
''Animal Reference Center

SS SSS

Title of
Center
and
Center
Director

Resource:

Registry of Comparative Pathology

The reference center is located on the campus
of the Walter Reed Medical Center in the Armed
Forces Institute of Pathology (AFIP), Washing-
ton, D.C. The center is administered jointly by
Universities Associated for Research and Edu-
cation in Pathology (UAREP) and by the AFIP
Its registry advisory committee is chaired by Dr.
Dante Scarpelli, professor and chairman of the
pathology department at Northwestern Univer-

Principal Investigator:

Dante G. Scarpelli, M.D., Ph.D.
Northwestern University

303 East Chicago Avenue
Chicago, Illinois 60611

(312) 649-8144

sity School of Medicine, and includes outstand-
ing pathologists who have special experience
and interest in comparative pathology.

 

Resources
Provided

@ Reference Services: The registry maintains
increasing collections of tissue and illustrative
material, all indexed in a “natural language”
computerized file and available for study. Sci-
entists Can use materials for research training,
research, or preparation for teaching. Registry
personnel conduct workshops, symposia, and
short courses; prepare exhibits; and loan study
sets and syllabi. A listing of the registry's study
sets is contained in the List of Education Aids
of the Armed Forces Institute of Pathology. The
registry publishes Comparative Pathology Bul-
letin; Handbook: Animal Models of Human Dis-
eases; and Educational Opportunities in Com-
parative Pathology, U.S. and Foreign Countries.
Principal types of service requests include: ani-
mal models for specific animal species, spe-
cific information about diseases in animals,
methodology, training, and career opportuni-
ties.

® Consultation Available: Consultation is avail-
able on histopathology of all animal cases of
interest from a comparative standpoint, espe-
Cially those that may have implications regard-
ing human disease or models of human dis-
ease. Service is provided to investigators on a
cooperative basis.

© Contact Person: George Migaki, DV.M.,
Armed Forces Institute of Pathology, Washing-
ton, D.C., (202) 576-2452.

 

Research
Emphasis or
Application

28

@ Basic Objectives: To collect, classify, and
study diseases of comparative pathology inter-
est. To utilize knowledge of diseases in many
animal species in order to benefit humanity.
''Special Animal Colony and Model Study

RES TE SESE LSI OE GN it DASE PE SEE EDIT OC LIN TBE EDT ALLE ASE LDL EE LEE BES

 

 

Title of Resource: Principal Investigator:

Center A Laboratory Marsupial for Biomedical John L. VandeBerg, Ph.D.

and Research Director, Genetics Department

Center Southwest Foundation for Research and

. Education
Director PO. Box 28147
San Antonio, Texas 78284
(512) 674-1410

Resources To Outside Investigators smearing, so that the timing of conception can

Provided @ Animals: Juvenile and adult gray short-tailed be determined for experiments requiring timed
opossums (Monodelphis domestica) are avail- pregnancies.
able for sale to qualified investigators. Limited @ Animals: The breeding colony contains ap-
numbers of Virginia opossums (Didelphis vir- proximately 800 adult and juvenile Monodel-
giniana) are also available for sale from time to phis domestica and 18 adult Didelphis vir-
time. giniana. Accurate pedigree records have been
To Collaborating Scientists and Graduate maintained from the time of introduction of the
Students animals into captivity; some pedigrees consist
@ Eligibility: Those wishing to conduct research of seven generations.
at this facility must have their projects reviewed e Contact Person: John L. VandeBerg, Ph.D.,
by the principal investigator. (512) 674-1410.
e Services: Services are provided without
charge to collaborating scientists, or on a fee
basis depending on the extent of the service
required and of the resources available at this
facility. Services that can be provided include
complete animal husbandry, medical care,
pathology, clinical chemistry, anesthesiology,
blood collection, immunization, electrophoretic
analyses, and serologic analyses. We are de-
veloping a method to monitor estrus via vaginal

Research @ Basic Objective: To develop a species of

Emphasis or ce marsupials as an en he conve-

. . nient laboratory animal for biomedical re-
Application saareh,

e Current Research: The marsupial colony is
being used in projects involving nutritional re-
quirements, timing of developmental events,
cytogenetics, immunogenetics, biochemical
genetics, X chromosome inactivation, in-
breeding, chemical carcinogenesis, and repro-
ductive endocrinology.

29
''Special Animal Colony and Model Study

SRDS APS A PRS LT NH

Title of
Center
and
Center
Director

Resource:
Animal Models for Comparative Medical
Research

Principal Investigator:

Gerald A. Hegreberg, DM.M., Ph.D.

Associate Professor

Department of Veterinary Microbiology and
Pathology

Washington State University

Pullman, Washington 99164

(509) 335-6661

 

Resources
Provided

@ Animals and Biological Materials: Animals,
tissues, and other specimens are provided to
the extent available from the following animal
models: the Chediak-Higashi syndrome (CHS)
of cats; myopathy of Labrador retriever dogs:
mucolipidosis in the cat; Ehlers-Danlos syn-
drome of dogs and cats; lysozyme deficiency
of rabbits; myasthenia gravis of dogs; com-
bined immunodeficiency in horses; inherited
prepuberal diabetes mellitus in Keeshond
dogs; several forms of chondrodysplasia of
dogs.

@ Other Services: Information on animal mod-
els investigated by the resource staff (see Cur-
rent Research). The resource staff is also inter-
ested in having other animal models referred to
it for further investigation or development.

® Contact Person: Gerald A. Hegreberg,
DM.M., Ph.D., (509) 335-6661.

 

Research
Emphasis or
Application

30

@ Basic Objectives: To locate animals with dis-
eases homologous or analogous to those oc-
curring in people. To define the disorders. To
do fundamental research on the diseases and
to disseminate the models to the research
community.

® Current Research: The Chediak-Higashi syn-
drome of cattle, mice, and cats; myopathy of
Labrador retriever dogs; mucolipidosis in the
cat; lysozyme deficiency of rabbits; inherited
canine myasthenia gravis; combined immuno-
deficiency disease of foals; inherited feline
tremors; inherited prepuberal diabetes mellitus
in Keeshond dogs; severals forms of chondro-
dysplasias of dogs.
''Special Animal Colony and Model Study

Title of Resource: Principal Investigator:
Center Capture, Maintenance, and Culture of Roger T. Hanlon, Ph.D.

d Loliginid Squids Marine Biomedical Institute
an University of Texas Medical Branch
Center 200 University Boulevard
Director Galveston, Texas 77550

(409) 761-2133

Coprincipal Investigator:
Won Tack Yang, Ph.D.
Marine Biomedical Institute
(409) 761-2133

 

Resources e Animals: The resource is under development.
i Lolliguncula brevis is now locally available for

Provided resident and visiting investigators. Additional
species of squids will be available in the future,
including: Loligo (Doryteuthis) plei, Loligo pea-
lei, and Loligo forbesi.
@ Other Services: Information is available to
advise others how to transport and maintain
live squids. Progress in the culture program
has made it possible to provide squids
(throughout their size and age range) for devel-
opmental and longitudinal studies of the giant
fiber system, synapses in the stellate ganglion,
the eye, etc. This may now be arranged on a
selective basis.
@ Contact Persons: Roger T. Hanlon, Ph.D.,
(409) 761-2133 X3659 or Raymond F. Hixon,
Ph.D., (409) 761-2133 X3660.

 

Research @ Basic Objective: To supply investigators in
Emphasis or neuroscience with adult squids the year round
Application for giant axon preparations and other experi-
mental neurophysiological procedures.
e@ Current Research: Research at the resource
includes investigations of the culture of squids
from hatchlings to adults in the laboratory; envi-
ronmental conditions required for transport and
maintenance of live squids; food requirements
of laboratory-reared and cultured squids; squid
life history; less injurious capture methods;
study of behavior and color changes as tools to
improve maintenance and culture methods.
Current use of squids by institutional research-
ers includes monoclonal antibodies to study
phototransduction and development in the ret-
ina, and anatomy and electrophysiology of the
statocyst organs as comparable models of con-
genital defects in the vestibular system of
mammals.

31
''Special Animal Colony and Model Study

Title of Resource: Principal Investigator:
Center Laboratory Culture of Octopus for Roger T. Hanlon, Ph.D.
and Biomedical Research Marine Biomedical Institute

University of Texas Medical Branch
Center 200 University Boulevard
Director Galveston, Texas 77550

(409) 761-2133

 

Resources @ Animals: The resource is under development.
Provided The species in culture are Octopus joubini, Oc-
topus maya, and Octopus bimaculoides. A lim-
ited number of octopuses, including eggs or
hatchlings, will be available on a selective
basis in early 1984.
@ Other Services: Information on the transport,
maintenance, and culture of octopuses is avail-
able. Information may also be obtained on the
potential uses of octopuses in research, espe-
Cially environmental toxicology, comparative
psychology, genetics, and physiology.
@ Contact Person: Dr. Roger T. Hanlon, The Ma-
rine Biomedical Institute, 200 University Blvd.,
League Hall H63, Galveston, Texas
77550-2772, (409) 761-2133.

 

Research @ Basic Objectives: To develop a reliable and
Emphasis or reproducible methodology for the large-scale
Applicati culture of large-egged octopuses, making |

pplication these well-developed molluscs readily available
for biomedical research.

@ Current Research: Evaluation of each spe-
cies’ tolerance to high-density culture; develop-
ment of simple, reproducible closed seawater
systems; identification and treatment of
disease-causing organisms; water quality toler-
ances; determinations of food preferences and
production of artificial food rations; and evalua-
tion of species’ suitability for various biomedi-
cal applications.

32
''Special Animal Colony and Model Study

EST a PET IS I PI EN EE a ESE

 

 

Title of Resource: Principal Investigator:
Center Mouse Mutant Gene Resource Eva M. Eicher, Ph.D.
and Bar Harbor, Maine 04609
(207) 288-3371 X240
Center
Director
Resources @ Animals: Mice with specific genes in various tion (En), frizzy (fr), furless (fs), fuzzy (fz), gen-
Provided categories, including: 1. Growth and endocrine: eralized lymphoproliferation disease (g/d),
disorganization (Ds), dwarf-J (dw’), hypophos- greasy (Gs), harlequin (Hq), nude (nu),
phatemia (Hyp), hypothyroid (hyt), kidney dis- streaker (nu*"), plucked (pk), rex (Re), scant
ease (kd), little (/it), sex reversal (Sxr), testicu- hair (sch), sparse-fur (spf), tabby (7a), velvet
lar feminization (7fm), tubby (tub). coat (Ve).
2. Neurological and ocular: aphakia (ak), ataxia 5. Pigment: white-bellied agouti (A*), white-
(ax’), blind sterile (bs), cribiform degeneration bellied agouti-J (A*”), white-bellied agouti-15J
(cri), Dickie’s small eye (Dey), ducky (du), gyro (Av'®©), beige-2J (bg), albino-9J (c*,
(Gy), hotfoot-4J (ho¥’), jittery (ji), jolting (jo), dense-2J (d*™), grizzled (gr), leaden (In),
lurcher (Lc), lethargic (/h), myotonia (mto), nu- mocha-2uJ (mh), blotchy (Mo"®), tortoise
clear cataract (nuc), ocular retardation-J (or), shell (Mo"), pewter (Mo*”), ochre (Och),
oscillator (ot), polysyndactylism (Ps), rabbit pink-eyed dilution (p), pink-eyed dilution-J (p’),
(rb), shaker-1 (sh-1), shambling (shm), tumbler ruby-eye 2-J (ru-2"), sepia (sea), slaty (sit),
(tb), tottering (tg), leaner (tg'*), trembler-J tabby (7a), taupe (tp).
(Tr), twitcher (twi). | Mice with chromosomal aberrations:
3. Skeletal: brachypodism-J (bp’), belly spot 1. Inversions: /n(X)1H.
and tail (Bst), droopy-ear-H (de"), head blebs 2. Robertsonian: Rb(16.17)7Bnr, Rb(10.11)8Bnr.
(heb), oligosyndactylism (Os), polysyndactyly 3. Reciprocal-X-autosomal: 7(X;4)37H,
(Ps), rachiterata (rh), sightless (Sig), hairpin tail T(X;11)38H, T(X;16)16H.
(T™), brachyury-2d (7), tailkinks (tk), ulna- 4. Insertional-X-autosomal: 7(X;7)1Ct.
less (U/), vestigial tail (vt). Continued on next page
4. Immunological and hair: balding (ba/), bare-
patches (Bpa), hairy ears (Eh), repeated epila-
Research @ Basic Objectives: To discover new inherited @ Current Research: Physiological and genetic
Emphasis or endocrine, neurological, and immunological analysis of anew recessive mutation causing
Application mutations of the mouse; to maintain as breed- obesity without diabetes; endocrine and ge-
pp ing pairs and preserve as frozen embryos a netic analysis of a new recessive mutation af-

number of established mouse mutations and
chromosomal aberrations; to develop geneti-
cally suitable stocks of new and established
mouse mutations for use in biomedical re-
search; and to make these mutant stocks avail-
able to interested investigators in the scientific
community.

fecting the thyroid gland; immunological and
genetic analysis of a new recessive mutation
causing hair defect and runting; and histolog-
ical and genetic analysis of a new recessive
mutation affecting the cerebellum. In addition,
allelism testing and linkage analysis of a num-
ber of new mutations are being conducted.

33
''Special Animal Colony and Model Study

 

Resources
Provided

5. Reciprocal-autosomal: 7(1;2)5Ca, T(1;7)40H,
T(1;9)27H, T(1;9)5Ei, T(1;13)70H, T(1;17)190Ca,
1(2;3)24H, T(2;4)1Ca, T(2;4)Sn, T(2;4)13H,
1(2;6)7Ca, T(2;8)26H, T(2;8)1Ei, T(2;9)11H,
T(2;11)30H, T(2;16)28H, T(3;17)4Ei, T(4;8)36H,
1(5:12)31H, 1(5;13)264Ca, T(7;15)9Ca,
1(7;18)50H, T(7;19)145H, T(8;16)17H,
1(9;17)138Ca, T(10;18)18H, T(10;13)199H,
1(11;13)3Ei, 1(11;19)42H, 1(13;17)2Ei,
1(16;17)43H.

6. Monosomy: XO.

Several linkage testing stocks and inbred
strains including Mus castaneus, |S/CamEi,
SF/CamEi, SK/CamEi, PERU-Atteck/Ei, and
Mus molossinus.

@ Contact Persons: Muriel T. Davisson or Eva
M. Eicher, (207) 288-3371 X340 or 240.

 

34
''Primate Breeding and Resource Projects

a

Title of
Center
and
Center
Director

Resource:

Baboon Breeding Program

A breeding colony of approximately 300 Papio
cynocephalus anubis housed in a 6-acre corral.
Nuclear colonies of Papio hamaadryas, Papio
papio, and Papio cynocephalus cynocephalus.

Principal Investigator:

William J. Goodwin, Ph.D.

Southwest Foundation for Research and
Education

PO. Box 28147

San Antonio, Texas 78284

(512) 674-1410

 

Resources
Provided

To Outside Investigators

e Animals: Baboons of varying ages will be
available for sale primarily to investigators sup-
ported by NIH grants and contracts.

To Collaborating Scientists and Graduate
Students

@ Eligibility: Those wishing to conduct research
at this breeding facility must have their projects
reviewed and approved by the principal investi-
gator.

e Services: The breeding colony is available
for research activities that do not interfere with
the primary mission of this program.

@ Animals: Approximately 700 Papio cyno-
cephalus anubis, 60 Papio hamaadryas, 35 Pa-
pio papio, and 90 Papio cynocephalus cyno-
cephalus.

e Contact Person: William J. Goodwin, Ph.D.,
(512) 674-1410.

 

Research
Emphasis or
Application

e Basic Research Mission: To produce colony-
bred baboons and to conduct research in pri-
mate genetics, behavior, and colony manage-
ment. Core Staff: Genetics, behavioral studies,
primate medicine, and husbandry. Guest Inves-
tigators and Graduate Students: Primate be-
havioral studies.

35
''Primate Breeding and Resource Projects

(A NE TPIT EE PR HRA Ai TORS LDA Se PE CE TR SRT a a

 

 

Title of Resource: Principal Investigator:
Center Breeding Colony of Galago Elwyn L. Simons, Ph.D.
and Duke University Primate Center
Cent 3705 Ervin Road
enter Durham, North Carolina 27705

Director (919) 489-3364
Resources @ Animals and Biological Materials: The breed-
Provided ing colony currently consists of approximately

65 Galago senegalensis moholi, 65 Galago

crassicaudatus, and 20 Galago garnettii. In the

interest of conserving animals, frozen cadav-

ers, when available, are for sale to investiga-

tors.

@ Other Services: The breeding colony is avail-

able for collaborative noninvasive research

projects that do not interfere with the basic ob-

jectives of the project. A detailed experimental

protocol must be submitted.

@ Contact Person: M. K. Izard, Ph.D., (919)

489-3364.
Research @ Basic Objective: To establish self-sustaining

: colonies of the Ga/ago species named above,
Pea i ed and to determine optimal husbandry tech-
Pp niques to maximize the captive breeding poten-

36

tial of these species.

e@ Current Research: Collection of information
on basic reproductive biology, development of
management techniques to improve reproduc-
tion, and the use of exogenous hormone ther-
apy to improve reproduction. Other research
areas include mother-infant behavior, infant de-
velopment, and infant socialization.
''Primate Breeding and Resource Projects

sense ranean ee IE IE IF AT EY EEE TSE

Title of
Center
and
Center
Director

Resource:
Caribbean Primate Research Center

The Caribbean Primate Research Center has
three locations: complete laboratory and animal
facilities at the Medical Sciences Campus in
San Juan, a 410-acre facility (Sabana Seca)
with gang cages and corrals near San Juan,
and one 40-acre island (Cayo Santiago) lo-
cated near Playa Humacao. More than 2,000
Old and New World monkeys (six species) are
available, with emphasis on rhesus monkeys
Continued on next page

Principal Investigator:

Delwood C. Collins, Ph.D.
Caribbean Primate Research Center
University of Puerto Rico

PO. Box 1053

Sabana Seca, Puerto Rico 00749
(809) 784-0322

 

Resources
Provided

To Outside Investigators

e Specimens Available: Tissue specimens, or-
gans, etc., are provided when available. Costs
of packaging and shipping are normally as-
sumed by the individual receiving the speci-
mens.

To Collaborating Scientists and Graduate

Students

e Eligibility: Those wishing to conduct research

at the center must have their projects reviewed

and approved by the center director and advi-

sory committee.

e Services: The center's services are available

to collaborating scientists. They include:
—Protocol Management: Complete man-
agement of research protocols including
drug administration, manipulation, speci-
men collection, and animal handling.
—Primate Medicine: Veterinary services,
surgery, hematology, clinical chemistry,
and necropsies.

e Animals: Macaca mulatta, M. arctoides, Sai-

miri sciureus, Erythrocebus patas, Cebus albi-

frons, C. apella. Most of the animals are housed
outside either in gang cages, corrals, or a free-
ranging island environment. The free-ranging
island population at Cayo Santiago has 600
free-ranging rhesus of known ages and mater-
nal genealogies. Current research policy for-
bids experimental manipulation of these mon-
keys. Observational studies are stressed.
However, a complete social group of the Cayo
Santiago monkeys has been established in a
two-acre corral at Sabana Seca. This social
group is available for more manipulative stud-
ies.

e Contact Persons: Delwood C. Collins, Ph.D.,
or Matt Kessler, DV.M., for animal studies, (809)
784-0322/6619; Dean Falk, Ph.D., curator,
(809) 753-5219.

 

Research
Emphasis or
Application

e Basic Research Mission: To conduct a

broadly based research program on the behav-

ioral and biomedical sciences using nonhuman

primates. Research with the rhesus and patas

monkeys is emphasized.

@ Current Research:
—Behavior: Behavioral and morphological
ontogeny of locomotion; patterns of ag-
gression and affiliation in free-ranging pa-
tas; dominance and affiliation among free-
ranging patas; population dynamics of
free-ranging rhesus; intergroup variation of
social behavior in rhesus monkeys; social
and ecological determinants of spatial rela-
tionships in rhesus; contextual and genea-
logic specifics of rhesus vocalizations, de-
velopment of free-ranging adolescent male
rhesus; infant rhesus socialization and play
behavior; the female role in mate selection
in rhesus monkeys; social group transfer of

male rhesus monkeys; pair-bonding and
male-female relationships in rhesus mon-
keys; behavioral characteristics of the
aged rhesus; familial support systems for
the aged and reproductively dysfunctional
adult rhesus.

—Endocrinology and Reproduction: Endo-
crine changes of puberty in the rhesus
monkey; seasonal control of ovulation in
the rhesus monkey; mechanism for mainte-
nance of high steroid levels in the New
World monkey; reproductive history of
aged rhesus monkeys; effects of nutrition
on hormones and reproduction,
—Genetics and Morphology: Genetic and
environmental components of skeletal mor-
phological variations in the rhesus; blood
genetics of group structure; bone and eye
Continued on next page

37
''Primate Breeding and Resource Projects

© GRR NNR AS CSE RAD SRRDIESN STN TEs LMR SIO SEER PERI PPR OTC OANA DER ES AB ES I

Title of
Center
and
Center
Director

maintained in social groups. Housing and labo-
ratory facilities are available for short-term ex-
periments conducted by visiting scientists and
students. Behavioral and life cycle research at
Cayo Santiago and Sabana Seca and biomedi-
cal research at Sabana Seca and the Medical
Science Campus are emphasized, and collabo-
rative research with scientists at the Primate
Center is encouraged.

Another important resource of the Center is a
skeletal collection from more than 600 rhesus
monkeys from Cayo Santiago with maternal ge-
nealogies and genetic information. This collec-
tion is curated and maintained in a museum lo-
cated in the Medical Science Center. These
skeletons are available for study at the Carib-
bean Primate Research Center or on loan with
the approval of the director.

 

 

Research
Emphasis or
Application

38

pathology of the rhesus; patterns of os-
teoarthritis in free-ranging rhesus and pa-
tas monkeys; kinematic analysis of loco-
motion in the rhesus.

—Immunology and Microbiology: Evalua-
tion of tetanus vaccines; evaluation of vac-
cines for dengue fevers; evaluation of vac-
cine for schistosomiasis; the rhesus
monkey as an experimental model of my-
asthenia gravis; the rhesus monkey as an
experimental model of the Guillain-Barré
syndrome; the epidemiology of tetanus in a
free-ranging rhesus population; the epide-
miology of SV-40 reactivity in a newly ex-
posed rhesus population.
''Primate Breeding and Resource Projects

 

 

Title of Resource: Principal Investigator:
Center Domestic Bolivian Squirrel Monkey Christian R. Abee, DV.M.
and Breeding Resource Division of Animal Health and Resources
Cent College of Medicine
enter University of South Alabama
Director Mobile, Alabama 36688
(205) 460-6239
Resources To Outside Investigators @ Services: Complete animal husbandry, med-
Provided © Specimens: Tissues and body fluids may be ical care, and pathology services are available
available on a collaborative basis. Such speci- without charge to investigators with approval
mens will be provided on a priority basis to from the principal investigator to use resource
those NIH-sponsored research projects that are colony animals.
related to the objectives of this research effort. @ Animals: The breeding colony currently con-
Costs of packaging and shipping are negoti- tains approximately 320 Bolivian squirrel mon-
ated on an individual basis to be determined by keys of varying ages. Some offspring and re-
the nature of the collaboration. productive culls are available.
To Collaborating Scientists and Graduate @ Contact Person: Christian R. Abee, DV.M.,
Students (205) 460-6239.
© Eligibility: Individuals interested in collabora-
tive studies must provide a protocol to the prin-
cipal investigator. Approval of collaborative
projects will depend upon the relevance of the
proposed project to the objectives of the ongo-
ing research effort.
Research @ Basic Research Mission: To carry out multi- Core Staff: Includes investigators conducting
Emphasis or disciplinary studies of captive reproduction in studies of medical primatology, reproductive
Application the Bolivian squirrel monkey and to provide a endocrinology, data management, primate
resource of laboratory-born and -reared ani- management and husbandry, and primate

mals for NIH-sponsored research programs.

e Current Research: The current research ef-
fort involves characterization of factors that in-
fluence captive reproduction with emphasis on
development of methods to improve reproduc-
tive potential. A multidisciplinary approach in-
corporating behavioral studies, reproductive
endocrinology, medical primatology, and cyto-
genetics is under way at present.

behavioral psychology.

Guest Investigators and Graduate Students:
Guest investigators and graduate students in-
terested in studies of factors influencing repro-
duction of squirrel monkeys in captivity are in-
vited to send letters of interest. These letters
will be considered based on two criteria: 1) the
relevance of the applicant’s interests to the on-
going research effort; and 2) the availability of
resources to meet the needs of the guest inves-
tigator.

39
''Primate Breeding and Resource Projects

 

Title of Resource:

Center Nonhuman Primate Breeding Contract
and

Center

Director

Resources @ Animals: The Animal Resources Program
Provided funds one contract to produce nonhuman pri-

40

mates for NIH grant- or contract-supported re-
search projects. The animals provided include
rhesus and cynomolgus monkeys. By special
arrangement, it is possible to screen the ani-
mals for specific desired characteristics. Re-
quests for animals are reviewed by NIH, which
makes specific allocations from the breeding
project.

© Body Fluids: By special arrangement, it is
also possible to obtain samples of body fluids
and tissues from animals in the breeding col-
ony.

@ Contact Person: Carl E. Miller, DVM., M.PH.,
Animal Resources Program, Building 31, Room
5B59, National Institutes of Health, Bethesda,
Maryland 202085, (301) 469-5175.
''Information Project

Title of
Center
and
Center
Director

Resource:
Institute of Laboratory Animal Resources
(ILAR)

Principal Investigator:

Earl Wayne Grogan, DM.M., M.P.H.
Executive Secretary

Institute of Laboratory Animal Resources
National Academy of Sciences

2101 Constitution Avenue, NW.
Washington, D.C. 20418

(202) 334-2590

 

Resources
Provided

@ Activities: LAR develops guidelines on labo-
ratory animal care and use, and conducts con-
ferences, symposia, and workshops on impor-
tant laboratory animal problems. The institute
publishes /LAR News, a quarterly journal, and
numerous special reports. A list of ILAR publi-
cations on laboratory animals is available. As a
part of the Animal Models and Genetic Stocks
Information Exchange Program, ILAR staff
members answer direct telephone and mail in-
quiries concerning laboratory animals and re-
spond to investigators’ requests on the exis-
tence and location of specific animal models.
ILAR also aids in the relocation of genetic
stocks that cannot be maintained at their origi-
nal sites.

@ Contact Person: Dorothy D. Greenhouse,
Ph.D., (202) 334-2590.

 

Research
Emphasis or
Application

e Basic Objectives: To develop and make
available to the biomedical community scien-
tific and technical information, guidelines, sur-
veys, and directories as a service to improve
the availability, quality, and utilization of labora-
tory animals.

41
''Information Project

Title of
Center
and
Center
Director

Resource:
Laboratory Primate Newsletter

Principal Investigator:

Allan M. Schrier, Ph.D.
Psychology Department

Brown University

Providence, Rhode Island 02912
(401) 863-2511

 

Resources
Provided

@ Reference Services: The resource has pub-
lished Laboratory Primate Newsletter quarterly
since 1962. Major categories of information pro-
vided: care, breeding, and supply of nonhuman
primates for laboratory studies; general infor-
mation and news bearing on research with non-
human primates; requests for research material
or related to specific research problems; and
conservation of nonhuman primates. A Direc-
tory of Graduate Programs in Primatology and
Primate Research is issued annually. Mailing list
is limited to persons who have a legitimate, rel-
atively long-term professional connection with
primate research either directly or in some sup-
portive role. Current issues are free of charge;
back issues are available for $2 each (checks
payable to Brown University).

© Contact Person: Allan M. Schrier, Ph.D., (401)
863-2511.

 

Research
Emphasis or
Application

42

@ Basic Objective: To provide news and infor-
mation that will be of help and interest to per-
sons involved in research with nonhuman
primates.
''Information Project

Title of
Center
and
Center
Director

Resource:
Primate Information Center

Project Manager:

Ms. Maryeva W. Terry

Primate Information Center SJ-50
Regional Primate Research Center
University of Washington

Seattle, Washington 98195

(206) 543-4376

 

Resources
Provided

e Services: The information center has devel-
oped and maintains a bibliographic data base
covering the scientific literature on nonhuman
primates published since 1940, indexed for pri-
mate species and scientific subject. Access to
the contents of this data base is available in a
variety of forms. Custom retrospective bibliog-
raphies cover specific research topics for indi-
vidual primate families, genera or species, or
nonhuman primates in general. Searches may
be restricted chronologically to most recent 5
years, most recent 10 years, 1965 to present, or
1940 to present. Custom monthly bibliogra-

phies provide recent additions to file, selected
by topic and/or primate. An irregular series of
printed bibliographies includes various kinds of
studies involving nonhuman primates. A
monthly title listing with authors’ addresses is
called Current Primate References. Each issue
has primate and author indexes.

® Contact Persons; Behavior and neuroscience
studies: Jean Williams, (206) 543-4376; bio-
medical studies: Benella Caminiti, (206)
543-4376.

 

Research
Emphasis or
Application

@ Basic Objective: To provide a single source
of bibliographic information on biomedical ex-
periments of which nonhuman primates are
subjects and on studies of the animals for
themselves, retrievable by any species.

@ Application of Service: The service is avail-
able internationally. Moderate fees are charged
for all services.

43
''Information Project

 

 

Title of Resource: Project Manager:
Center Primate Supply Information Clearinghouse Ms. Maryeva W. Terry
and Primate Information Center, SU-50
Regional Primate Research Center
Center University of Washington
Director Seattle, Washington 98195
(206) 543-4376

Resources @ Services: The clearinghouse matches re-
Provided search needs for nonhuman primates and pri-

mate materials such as blood samples, tissues,

and cadavers, with resources available from

other institutions. Any needs and availabilities

that are not immediately matched are pub-

lished in New Listings—Primate Supply Infor-

mation Clearinghouse. The clearinghouse also

has a data bank on colonies and other possible

sources of primates and primate materials to

which notices of availability and need can be

referred.

® Contact Person: Thea Sutherland, (206)

543-5178.
Research @ Basic Objectives: To promote conservation of
Emphasis or nonhuman primates by reducing laboratory de-
Application mand on wild populations. To make the best.

possible use of available research primates in

44

the United States by facilitating the sequenced
use of nonhuman primates in biomedical re-
search and to effect speedier communication
between users. Investigators and colony man-
agers are invited to list their animals available
for transfer or to be shared and to consult the
clearinghouse regarding availability of animals,
etc., for new projects.

e@ Application of Service: The service is avail-
able without charge to government-supported
researchers and to other scientists in the
United States using primates in their work. Ser-
vices except New Listings are also available to
scientists in other countries.
''Information Project

ne Ea

Title of
Center
and
Center
Director

Resource:
Registry of Specialized Genetic Stocks

Principal Investigator:

Ralph G. Somes, Jr., Ph.D.
Nutritional Sciences Department U-17
University of Connecticut

Storrs, Connecticut 06268

(203) 486-3632

 

Resources
Provided

@ Reference Services: The International Regis-
try of Poultry Genetic Stocks—A Directory of
Specialized Lines and Strains, Mutations,
Breeds, and Varieties of Chicken, Japanese
Quail, and Turkey (4th edition) describes and
lists the locations of 1,067 genetic stocks from
16 countries. The stocks are of value to geneti-
cists, physiologists, embryologists, and other
biologists. In addition to the descriptions and
listings of the genetic stocks, the Registry also
includes chromosome maps for each of the
three species and categorized listings of all
their Known genetic traits along with gene sym-
bols. There is a section on chicken plumage
color in which the phenotypes are described

and listed according to the E locus alleles, and
the genotypes are presented when known. The
fifth edition of the Registry will be published in
1984. Past and potential new contributors are
invited to submit current information on avail-
able stocks at any time. The Registry is avail-
able for $3 from Storrs Agricultural Experiment
Station Publications, University of Connecticut,
Storrs, Connecticut 06268.

® Contact Person: Ralph G. Somes, Jr, Ph.D.,
(203) 486-3632.

 

Research
Emphasis or
Application

@ Basic Objective: To compile in the form of a
published registry a listing of the various spe-
cialized lines, mutant genes, and breeds and
varieties of domestic chickens, turkeys, and
Japanese quail available in the United States,
Canada, and some other countries. To make
available basic genetic information relating to
these three species to biomedical scientists
who may find them of value as models in vari-
ous studies.

45
''46
''Geographic Index

Alabama

@ Animal Diagnostic Laboratory
Laboratory Animal Resource for Biomedical
Research (Birmingham)
P19

@ Primate Breeding and Resource Project
Domestic Bolivian Squirrel Monkey Breeding
Resource (Mobile)
P. 39

California

@ Primate Research Center
California Primate Research Center (Davis)
P4

Connecticut

@ Information Project
Registry of Specialized Genetic Stocks
(Storrs)
P. 45

@ Animal Diagnostic Laboratory
Resource for the Study of Laboratory Animal
Diseases (New Haven)
P. 23

District of Columbia

@ Information Project
Institute of Laboratory Animal Resources
(ILAR) (Washington)
P41

Georgia
@ Primate Research Center
Yerkes Regional Primate Research Center

(Atlanta)
P41

Ilinois

e@ Animal Reference Center
Registry of Comparative Pathology (Chicago)
P. 28

Louisiana

@ Primate Research Center
Delta Regional Primate Research Center
(Covington)
P5

(a ns eS EE I TE EST RTE STE EE LE SL SARE BE

Maine

e Animal Reference Center
Cryopreservation of Murine Germplasm (Bar
Harbor)
P27

@ Special Animal Colony and Model Study
Mouse Mutant Gene Resource (Bar Harbor)
P. 33

Maryland

e@ Animal Diagnostic Laboratory
Animal Resource Support for Biomedical
Research (Baltimore)
P16

e Primate Breeding and Resource Project
Nonhuman Primate Breeding Contract
(Bethesda)
P. 40

Massachusetts

e Primate Research Center
New England Regional Primate Research
Center (Southborough)
P6

e@ Animal Diagnostic Laboratory
Research Animal Diagnostic Laboratory
(Cambridge)
P. 22

Michigan

e@ Animal Diagnostic Laboratory
University Resource in Laboratory Animal
Medicine (Ann Arbor)
P25

Minnesota

@ Animal Diagnostic Laboratory
Animal Disease Diagnostic and Investigative
Laboratory (Minneapolis)
P14

Missouri

@ Animal Diagnostic Laboratory
Research Animal Diagnostic and
Investigative Laboratory (Columbia)
P21

47
''Geographic Index

SN a PE SE ET

48

New York

@ Animal Diagnostic Laboratory
Diagnostic Research and Clinical Laboratory
Program (New York)
P17
Laboratory for Marine Animal Health (Ithaca)
P20

North Carolina

@ Animal Diagnostic Laboratory
Resource for the Study of Nonhuman
Primates (Winston-Salem)

P24

@ Primate Breeding and Resource Project
Breeding Colony of Galago (Durham)

P. 36

Oregon

@ Primate Research Center
Oregon Regional Primate Research Center
(Beaverton)
P7

Pennsylvania

@ Animal Diagnostic Laboratory
Laboratory Animal Diagnostic Resource
(Hershey)

P18

Puerto Rico

@ Primate Breeding and Resource Project
Caribbean Primate Research Center (Sabana
Seca)

P. 37

Rhode Island

@ Information Project
Laboratory Primate Newsletter (Providence)
P 42

Texas

@ Animal Diagnostic Laboratory
Animal Resources Diagnostic and
Investigative Laboratory (Dallas)
P15

@ Special Animal Colony and Model Study
A Laboratory Marsupial for Biomedical
Research (San Antonio)
P 29
Capture, Maintenance, and Culture of
Loliginid Squids (Galveston)
P 31
Laboratory Culture of Octopus for Biomedical
Research (Galveston)
P32

@ Primate Breeding and Resource Project
Baboon Breeding Program (San Antonio)
P' 35

Washington

@ Animal Diagnostic Laboratory
Animal Diagnostic and Investigative
Laboratory (Seattle)
P13

@ Special Animal Colony and Model Study
Animal Models for Comparative Medical
Research (Pullman)
P 30

@ Information Project
Primate Information Center (Seattle)
P43
Primate Supply Information Clearinghouse
(Seattle)
P 44

@ Primate Research Center
Regional Primate Research Center at the
University of Washington (Seattle)
P8

Wisconsin

@ Primate Research Center
Wisconsin Regional Primate Research Center
(Madison)
P10

*U.S. GOVERNMENT PRINTING OFFICE : 1983 0-421-894/4167
''''''DISCRIMINATION PROHIBITED: Under
provisions of applicable public laws en-
acted by Congress since 1964, no person in
the United States shall, on the grounds of
race, color, national origin, handicap, or
age, be excluded from participation in, be
denied the benefits of, or be subjected to
discrimination under any program or activity
(or, on the basis of sex, with respect to any
education program or activity) receiving
Federal financial assistance. In addition, Ex-
ecutive Order 11141 prohibits discrimina-
tion on the basis of age by contractors and
subcontractors in the performance of Fed-
eral contracts, and Executive Order 11246
states that no federally funded contractor
may discriminate against any employee or
applicant for employment because of race,
color, religion, sex, or national origin. There-
fore, the Animal Resources Program must
be operated in compliance with these laws
and Executive Orders.
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