bigram

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bigram	frequency
et al	1965
biorxiv preprint	1549
peer review	1549
author funder	1548
copyright holder	1548
version posted	1548
preprintthis version	1539
posted january	1539
preprint https	1499
org licenses	1153
granted biorxiv	1152
international licenseavailable	706
licensemade available	446
international licensemade	446
rights reserved	396
without permission	396
allowed without	396
reuse allowed	396
cell lines	147
amino acids	142
disulfide bond	112
mm nacl	104
hbv integration	97
crystal structure	96
active site	95
amino acid	94
mass spectrometry	90
outer membrane	86
editing frequency	82
nucleic acids	81
fatty acid	79
pi kc	77
fatty acids	76
lipid species	76
mm tris	75
supplementary table	74
mg ml	74
ulk complex	73
ps ta	69
ms ms	69
pc pc	66
au content	66
biol chem	66
saccharomyces cerevisiae	66
lc lipidation	64
signal peptide	64
extended data	64
rna editing	63
ps ps	62
spike protein	62
natl acad	62
acad sci	62
endothelial cells	61
editing sites	61
mol biol	61
proc natl	60
pg pg	58
mitochondrial copper	57
secondary structure	57
cell line	56
rpe cells	56
synuclein filaments	56
biological replicates	55
performed using	55
previously described	55
pe pe	54
state sufb	53
cancer cell	52
supplemental figure	52
li ions	52
ccn scores	50
pi pi	50
electron microscopy	50
room temperature	50
acids res	50
fig ev	49
mm hepes	49
bond formation	49
ddb dcaf	49
kda kda	49
cylc homologs	48
tax bp	48
western blot	47
ccn score	47
edited cytidine	47
nascent chain	47
molecular dynamics	46
disulfide bonds	46
time min	46
cell surface	46
oxidative stress	45
gene expression	45
van der	43
heparan sulfate	43
data collection	43
mol cell	43
sp lege	42
technical replicates	41
training data	41
mm mgcl	41
integration sites	41
integration sequences	41
peptide cleavage	41
icrocystis aeruginosa	40
trigger channel	40
cell biol	40
flow cytometry	39
pa pa	39
gated ion	39
fold change	39
inner membrane	39
stat activation	39
binding site	39
dimer bound	39
mm tcep	39
trypanosoma cruzi	38
supplementary fig	38
de novo	37
cancer type	37
previously reported	37
exclusion chromatography	37
simulated diabetes	37
standard deviation	37
mooring sequence	37
respiratory growth	36
hepes ph	36
em structure	36
cell adhesion	36
aa ca	36
thermo fisher	35
pdb id	35
copper homeostasis	35
binding affinity	35
graphpad prism	35
ca rnc	35
containing mm	35
independent experiments	34
yn ec	34
pdi erp	34
terminal region	34
electronic health	34
fisch erella	33
electron density	33
expression profiles	33
ge healthcare	33
ec ho	33
stat phosphorylation	33
type iii	33
phosphate buffer	33
ion channel	32
sequence alignment	32
general classification	32
breast cancer	32
supplementary figure	32
cancer cells	32
structural basis	32
mathematical models	32
hydrogen bonds	31
plos one	31
escherichia coli	31
subtype classification	31
buffer containing	31
afm images	31
liquid nitrogen	31
stem helix	31
host cell	31
easy kinetics	31
data set	30
different concentrations	30
sulfur starvation	30
endoplasmic reticulum	30
metal ion	30
fisher scientific	30
statistical analysis	30
metal ions	30
formic acid	30
deep learning	30
molecular weight	30
epithelial cells	30
vacuolar ph	30
cs ds	30
lytic polysaccharide	29
epimastigote forms	29
cleavage site	29
cko mice	29
sp le	29
cargo receptors	29
mm dtt	29
anaerobic growth	29
op si	29
nascent chains	29
walls et	29
flow rate	29
way anova	28
generated using	28
dna repair	28
mrna editing	28
min ps	28
wild type	28
taken together	28
thermo scientific	28
protein complex	28
described previously	28
target site	28
cell cycle	28
general ccn	28
binding domain	28
crystal structures	28
data fig	27
isobaric trigger	27
cancer models	27
pk mata	27
hg hi	27
gene essentiality	26
ribosome exit	26
protein synthesis	26
fluorescence intensity	26
gag chain	26
health care	26
pigment epithelium	26
retention time	26
ic values	26
bond introduction	26
three biological	26
mm imidazole	26
na na	26
two technical	26
size exclusion	26
showing mean	26
cell death	25
std dev	25
ms analysis	25
cysteine residues	25
native disulfide	25
tumor type	25
three independent	25
nat struct	25
mm edta	25
density map	25
protein expression	25
ligand binding	25
biological chemistry	25
study jr	25
ray structures	25
error bars	25
selective autophagy	24
western blotting	24
statistical significance	24
protein complexes	24
hsa nascent	24
sp pcc	24
drug prescriptions	24
unit increments	24
tumor types	24
herm alis	24
authors declare	24
genomic features	24
figure legends	24
md simulations	24
supp tab	24
cyano bium	24
per unit	24
regulatory sequence	24
acids research	24
ctd vprmus	24
pan cancer	24
gene induction	23
acta crystallogr	23
tcga pan	23
aeruginosa le	23
author contributions	23
cell proliferation	23
anticodon loop	23
wang et	23
monoclonal antibody	23
see figure	23
blot analysis	23
standard deviations	23
yeast display	23
casp domain	23
molecular biology	23
conformational changes	23
genetic regulators	23
dna duplex	23
cell lysates	23
respiratory syndrome	23
study cen	23
ra ci	23
classical cadherins	22
pixel size	22
calculated using	22
high glucose	22
dna complex	22
wash buffer	22
bo rs	22
results showed	22
data analysis	22
mammalian cells	22
dependent halogenases	22
polysaccharide monooxygenase	22
stdratio values	22
pentameric ligand	22
gp folding	22
rs ki	22
cell biology	22
sp er	22
downstream sequence	22
ci bo	22
genomic dna	22
molecular mechanisms	22
antiviral agent	22
mathematical model	22
chen et	22
experimental data	21
care records	21
final concentration	21
time course	21
mass spectrometer	21
thermofisher scientific	21
em structures	21
bium sp	21
ovarian cancer	21
zinc ion	21
determined using	21
spike glycoprotein	21
highly conserved	21
coronary artery	21
raw data	21
chondroitinase abc	21
supp fig	21
immune system	21
met cysteine	21
membrane recruitment	21
sample buffer	21
er membrane	21
pdi family	21
potential antiviral	21
ss ss	21
struct mol	21
ubiquitin ligase	21
negative control	21
secretion system	21
reducing agent	20
seq classifier	20
directed mutagenesis	20
results show	20
mycobacterium tuberculosis	20
gene pairs	20
hela cells	20
cell types	20
competing interests	20
kanmx met	20
prescription events	20
agent page	20
fi time	20
dynamics simulations	20
mm kcl	20
urease inhibitors	20
free linker	20
ace binding	20
results suggest	20
rpe phagocytosis	19
chase experiments	19
cy st	19
struct biol	19
prion protein	19
helix bundle	19
data availability	19
bars indicate	19
binding pocket	19
ho cy	19
dna binding	19
cells expressing	19
exit site	19
ml min	19
lipid classes	19
rna polymerase	19
acute respiratory	19
phosphorylation kinetics	19
side chain	19
study js	19
first prescription	19
gsh gssg	19
low normal	18
human snm	18
pre complex	18
vitro ubiquitination	18
liquid chromatography	18
jr jr	18
disulfide formation	18
prescription event	18
structure determination	18
atomic force	18
three times	18
beta peptide	18
enzyme kinetics	18
washed twice	18
fatty acyl	18
cell membrane	18
quality control	18
inner domain	18
biophys acta	18
data bank	18
wt vs	18
aa lpmos	18
publicly available	18
purified protein	18
light chain	18
corresponding author	18
two molecules	18
scale bar	18
transcription factor	18
sample preparation	18
data table	18
clinical events	18
attention intensive	18
cancer types	18
human plasma	18
catalytic domain	18
covid moonshot	18
biochim biophys	18
receptor binding	18
severe acute	18
one representative	18
western blots	18
authors contributed	18
base content	18
frameshifting efficiency	18
lipid droplets	17
lysis buffer	17
naturally occurring	17
family enzymes	17
bl et	17
two cytokines	17
com work	17
bronchial epithelial	17
neutralizing antibodies	17
well plate	17
contributed equally	17
zinc finger	17
dwell time	17
yeast cells	17
fi ps	17
nat methods	17
differential expression	17
sili ne	17
aa family	17
thermal stability	17
particle images	17
tandem lesions	17
ta bl	17
legume kai	17
mm phosphate	17
also observed	17
enzyme activity	17
chemostat cultures	17
work bibliography	17
side chains	17
seq data	17
kluyveromyces marxianus	17
lanktoth rix	17
atp atp	17
target proteins	17
affinity chromatography	17
ace receptor	17
editing targets	17
ex vivo	17
artery endothelial	17
force microscopy	17
acta crystallographica	17
affinity purification	17
expression levels	17
endonuclease domain	17
structural insights	16
loaded onto	16
sequence motif	16
positively charged	16
ccn classifier	16
intrinsically disordered	16
nat commun	16
small molecules	16
dna substrate	16
cell viability	16
right panel	16
tris ph	16
gel filtration	16
statistical software	16
enzymatic activity	16
well plates	16
course snapshots	16
proteome profiling	16
apob rna	16
oxidative folding	16
phosphorylated stat	16
random forest	16
retinal pigment	16
cells using	16
binding sites	16
nonheme iron	16
molecular basis	16
salicylic acid	16
seffouh et	16
rbd domain	16
grn status	16
local resolution	16
previous studies	16
log nm	16
scale bars	16
em data	16
cancer research	16
ds chain	16
bibliography http	16
chem biol	16
small molecule	16
supplementary information	16
helicobacter pylori	16
magnetic resonance	16
slide number	16
transcription factors	16
syndrome coronavirus	16
data figure	15
vii secretion	15
kinetic parameters	15
immunodeficiency virus	15
ms lda	15
atomic model	15
drug discovery	15
type ii	15
crl dcaf	15
lung cancer	15
pcag hekgnti	15
decision threshold	15
ha met	15
annu rev	15
stat stat	15
type vii	15
prop gender	15
oxygen requirements	15
cyano bacter	15
bacter ium	15
classification profiles	15
ami gender	15
may also	15
signal peptides	15
cell lysate	15
de la	15
cadherin ec	15
refinement statistics	15
dna double	15
dna damage	15
le ge	15
stationary phase	15
bound dna	15
free fatty	15
monoclonal antibodies	15
human beta	15
cells ml	15
autophagosome formation	15
acid metabolism	15
machine learning	15
ion channels	15
redox state	15
ucsf chimera	15
analysing drug	15
even though	15
sle patients	15
enrichment analysis	15
protein folding	15
ion mode	15
anaerobic conditions	15
yeast strains	15
conditioned medium	15
positive control	15
water molecules	15
dna target	15
page analysis	15
analyzed using	15
dna targets	15
lignocellulosic biomass	15
genome sequencing	15
schematic representation	15
fo ld	14
acid sequence	14
ho co	14
mbl fold	14
data acquisition	14
cell culture	14
legends figure	14
mutant nsclc	14
putative targets	14
sci rep	14
alis wc	14
polymerase ii	14
mm cacl	14
cancer res	14
thermal proteome	14
bound enzyme	14
solution containing	14
nature reviews	14
type diabetes	14
multiple sequence	14
atp mn	14
pqa score	14
life technologies	14
nsclc cell	14
therapydf testtherapydf	14
two groups	14
lipid metabolism	14
imputation model	14
wd wd	14
light chains	14
new england	14
viral entry	14
frameshifting trnas	14
pstat pstat	14
converting enzyme	14
cancer genome	14
mes buffer	14
life sciences	14
transcriptional fidelity	14
mm mg	14
flagellum basal	14
ap site	14
novel coronavirus	14
expression data	14
force field	14
mouse model	14
luo et	14
co cc	14
mm sodium	14
experimental group	14
terminal subunit	14
al es	14
small intestine	14
coronavirus spike	14
state nmr	14
differentially expressed	14
final volume	14
national institutes	14
nuclear magnetic	14
final model	14
mm glucose	14
quadruplet codon	14
tycho nem	14
std signal	14
tht fluorescence	14
elongation cycle	14
family members	14
molecular conformations	14
post complex	14
scan area	14
sustained stat	14
stably expressing	14
cytokine signaling	14
endonuclease domains	14
current status	13
mixed disulfide	13
membrane binding	13
synuclein filament	13
sucrose density	13
damaged system	13
binding proteins	13
low abundance	13
protein concentration	13
sp cells	13
membrane translocation	13
protein structure	13
basal body	13
anal chem	13
tolyngb ya	13
hd domain	13
cell aggregation	13
ray structure	13
lep tolyngb	13
pdb code	13
membrane proteins	13
carboxylate halogenases	13
cerevisiae cen	13
classification scores	13
indicate standard	13
pseudotyped virus	13
ne ne	13
proteinogenic amino	13
cc al	13
sp erm	13
also known	13
cold spring	13
number slide	13
measured using	13
carbon sources	13
attention weight	13
binding time	13
go terms	13
hcl ph	13
ly ng	13
land et	13
protein data	13
supplementary figures	13
apob mrna	13
deephbv model	13
control mice	13
stem cells	13
cytoplasmic domain	13
membrane protein	13
bovine serum	13
spike monomer	13
protein interactions	13
relative nmi	13
dependent cell	13
neural network	13
editing site	13
glutamic acid	13
learning model	13
regression model	13
phylogenetic tree	13
mm mes	13
endonuclease activity	13
state movies	13
broadly neutralizing	13
acid oxidation	13
like motif	13
domain interface	13
buchnera aphidicola	13
normal distribution	13
time points	13
dna substrates	13
also found	13
pearson correlation	13
hepatocellular carcinoma	12
ace activity	12
normal low	12
urease activity	12
iron og	12
signal sequence	12
mol microbiol	12
data show	12
dna lesions	12
determine whether	12
codon position	12
regulatory motif	12
density gradient	12
structural analysis	12
expressing cells	12
formation assays	12
analysis using	12
cartoon representation	12
ms data	12
posterior distributions	12
translation system	12
free tail	12
gene pair	12
pstat via	12
yeast surface	12
movie ev	12
met gene	12
negatively charged	12
intensive regions	12
transfected cells	12
synergistic effect	12
gp th	12
supplementary materials	12
molecular mechanism	12
met ubiquitination	12
protein localization	12
guv tracing	12
erp molecules	12
plasma membrane	12
cytokine receptor	12
nucleotide sequences	12
fi pstat	12
usa department	12
results indicate	12
mica surface	12
density maps	12
differentially essential	12
dna helix	12
signaling pathways	12
attention mechanism	12
sodium phosphate	12
cyanobacterial genomes	12
affinity maturation	12
furin cleavage	12
truncated artemis	12
protein interaction	12
outer segments	12
stat via	12
reference genome	12
hf risk	12
cancer category	12
hydrophobic pocket	12
gender gender	12
al iz	12
dissociation constant	12
structural studies	12
disulfide isomerization	12
essential genes	12
data indicate	12
endosulfatase activity	12
wallin et	12
subtype classifiers	12
van anken	12
sulfur metabolites	12
acs chem	12
electron microscope	12
pnpla gene	12
biological replicate	12
least one	12
mean values	12
substrate recognition	12
ip buffer	12
fluorescence microscopy	12
editing frequencies	12
clinicaldf testclinicaldf	12
cpf subunits	12
vpx vpr	12
gene ontology	12
molecular graphics	12
general tumor	12
natural products	12
left panel	12
binding protein	12
time trajectories	12
reducing sugar	12
classification general	12
time weightage	12
eto treatment	12
see also	12
cancer categories	12
type classification	12
sg repeat	12
nickel ion	12
individual guv	12
endothelial cell	12
cox cox	12
across different	12
large scale	12
mass spectrometric	12
strand break	12
united kingdom	12
ium sp	12
novo sequencing	12
gssg mal	12
iz ed	12
copper levels	12
see table	12
detection reagent	11
mm pmsf	11
mitochondrial respiratory	11
optical density	11
molecular cell	11
ac te	11
signal intensity	11
method using	11
lic ho	11
cell envelope	11
box protein	11
chem soc	11
forest classifier	11
data suggest	11
triplet pairing	11
previous study	11
isomer isomer	11
marxianus cbs	11
fractions containing	11
met met	11
positive cells	11
images showing	11
ray crystallography	11
membrane insertion	11
synuclein polymorph	11
hydrogen bond	11
ligase activity	11
kd values	11
protease inhibitor	11
cell rep	11
ob ac	11
cells incubated	11
host microbe	11
primer extension	11
synthetic lethality	11
target sites	11
cell aggregates	11
human bronchial	11
transmission electron	11
aa time	11
appendix fig	11
dependent genes	11
human monoclonal	11
medcodelist headachecodes	11
distinct molecular	11
loading control	11
korotkova et	11
gastric cancer	11
negative bacteria	11
respiratory chain	11
visual inspection	11
vprmus samhd	11
biological crystallography	11
js js	11
correlation coefficient	11
nat immunol	11
model building	11
microplate reader	11
cpf complex	11
lieber mr	11
titan krios	11
genome atlas	11
induced frameshifting	11
protein disulfide	11
rcsf variants	11
blanc et	11
membrane fusion	11
culture medium	11
iii secretion	11
england biolabs	11
previously shown	11
initial model	11
nmr spectra	11
linear regression	11
zong et	11
genes required	11
intercalation triad	11
pstat levels	11
efret vs	11
large number	11
three different	11
gel electrophoresis	11
mitochondrial function	11
serum albumin	11
migrating proteoform	11
structural biology	11
derived factor	11
research center	11
fibril formation	11
boosting effect	11
single molecule	11
supplementary material	11
binding mode	11
protein levels	11
te riu	11
downregulated genes	11
cco activity	11
cells grown	11
proteomic changes	11
structural features	11
cylc homolog	11
vpr proteins	11
affinity purified	11
ccn classification	11
dna sequences	11
cell host	11
type specific	11
coomassie blue	11
human cells	11
ho sp	11
amyloid beta	11
nm ps	11
finger like	11
main text	11
time point	11
bayesian inference	11
lactate media	11
oxysterol target	11
zinc ions	10
tripeptide formation	10
co production	10
identify genes	10
chain length	10
kinase activity	10
processed using	10
lee et	10
molecular replacement	10
maximal il	10
substrate binding	10
purified using	10
width wrap	10
biological functions	10
er lumen	10
protease inhibitors	10
research council	10
main stem	10
primary human	10
dna methylation	10
different species	10
von heijne	10
cells per	10
lf id	10
mrna levels	10
two different	10
cys residue	10
stat response	10
stranded dna	10
confocal images	10
ya sp	10
cell models	10
human immunodeficiency	10
pathway enrichment	10
biochem biophys	10
lipoprotein sorting	10
genome recoding	10
control group	10
pc pe	10
human li	10
chem int	10
js dh	10
present study	10
nature communications	10
genes encoding	10
oly ng	10
reaction monitoring	10
reference genomes	10
ps pa	10
post complexes	10
widely used	10
yeast deletion	10
independently repeated	10
much higher	10
re gu	10
pe pg	10
gov pubmed	10
scheduled mrm	10
investigated whether	10
translocation insertion	10
multiple reaction	10
per well	10
binding motif	10
pylori urease	10
gene cluster	10
ai ve	10
kd nm	10
bound drdv	10
ace expressing	10
scientific research	10
mbl domain	10
anova followed	10
crystallographica section	10
nos toc	10
van dijken	10
important role	10
protein translocation	10
clustering analysis	10
nd codon	10
growth media	10
wt il	10
treated hsulf	10
rice straw	10
outer segment	10
divergent sequences	10
flask cultures	10
patient derived	10
pg pi	10
inhibitor cocktail	10
entity recognition	10
cko mouse	10
strand breaks	10
date df	10
pylori infection	10
sequences tcga	10
model selection	10
anken et	10
flag ip	10
heavy chain	10
phylogenetic analysis	10
national institute	10
representative result	10
cell proteomics	10
ni es	10
biomass hydrolysis	10
molecular docking	10
available data	10
espb oligomer	10
united states	10
logistic regression	10
flag tag	10
sustained pstat	10
marxianus strains	10
aggregation kinetics	10
containing bgcs	10
substrate specificity	10
disulfide isomerase	10
data processing	10
dna glycosylase	10
main protease	10
accessory proteins	10
light source	10
human ace	10
length protein	10
representative confocal	10
mechanisms underlying	10
phorm idium	10
copper supplementation	10
survival analysis	10
fold induction	10
aa mono	10
restriction factor	10
phys chem	10
calculated based	10
terminal domain	10
rmsd values	10
colorectal cancer	10
mutation status	10
orf protein	10
ubiquitin ligases	10
infection model	10
transcriptome analysis	10
wide range	10
folding intermediates	10
dmso alone	9
length artemis	9
pnpla mrna	9
fred hutchinson	9
three days	9
re ss	9
san francisco	9
posted december	9
classification results	9
rbd binding	9
sigma aldrich	9
photoreceptor outer	9
triggered lc	9
frameshifting trna	9
ocystis aer	9
indicated concentrations	9
cell pellets	9
thermotolerant yeast	9
human cancer	9
medical sciences	9
cell entry	9
structural proteins	9
equimolar mixture	9
casp domains	9
expressing wt	9
open biosystems	9
high insulin	9
dipeptide formation	9
inhibition assays	9
nat rev	9
growth conditions	9
theme bw	9
plos genet	9
pol ii	9
dh drcsf	9
pstat activation	9
classification score	9
ubiquitination assay	9
de saint	9
data point	9
high throughput	9
stepped hcd	9
least twice	9
positive samples	9
culture collection	9
icr ocystis	9
interaction network	9
negative samples	9
type gp	9
er iu	9
biol cell	9
polysaccharide monooxygenases	9
assay kit	9
proportional hazards	9
cells stimulated	9
ct er	9
cells stably	9
type isp	9
pi ps	9
hutchinson cancer	9
schofield cj	9
angew chem	9
data sets	9
helical twist	9
dominant co	9
sf cells	9
receptor assembly	9
making use	9
single particle	9
influenza virus	9
equation used	9
mobile phase	9
neurodegenerative diseases	9
sorting signal	9
lines indicate	9
monomeric spike	9
collision energy	9
restriction enzymes	9
growth factor	9
surface receptor	9
cells nr	9
second metal	9
rpn kda	9
supplemental table	9
ba ct	9
basal bodies	9
differential essentiality	9
cell carcinoma	9
li et	9
catalytic site	9
results shown	9
fusion machinery	9
saint germain	9
internal standards	9
figure ev	9
research network	9
dashed lines	9
imd score	9
inhibitory effects	9
ss io	9
xp re	9
factor dominance	9
pbs supplemented	9
microscopy data	9
image processing	9
catalytic activity	9
negative stain	9
binding interface	9
female cell	9
final buffer	9
ulk kinase	9
thank dr	9
tuberculosis espb	9
synuclein aggregates	9
wasthis version	9
aer uginosa	9
vitro translation	9
wt cells	9
terminal linker	9
signaling pathway	9
human breast	9
sequence similarity	9
cruzi epimastigotes	9
autophagy initiation	9
df testtherapydf	9
disordered linker	9
sulfate proteoglycans	9
snapp et	9
vprmus helix	9
free cysteines	9
experimentally determined	9
dna strand	9
various concentrations	9
type iil	9
plos pathog	9
genome biol	9
surface area	9
dna sequence	9
extension inhibition	9
time window	9
least two	9
bovine coronary	9
rpe il	9
gene set	9
classification heatmap	9
com acnash	9
different lipid	9
control sample	9
smfret experiments	9
clustering methods	9
san diego	9
abasic site	9
enzymatic activities	9
upregulated genes	9
activity assay	9
iron homeostasis	9
cu ions	9
methyl group	9
envelope glycoprotein	9
science foundation	9
mpro active	9
dotted lines	9
first step	9
surface plasmon	9
kai receptors	9
sequence coverage	9
high resolution	9
legecc strains	9
severely oxygen	9
dependent manner	9
running title	9
induction log	9
plasmon resonance	9
sequence homology	9
motion correction	9
functional genomics	9
toc sp	9
enzyme subunit	9
synuclein aggregation	9
shah et	9
porous membranes	9
irf protein	9
data points	8
seq expression	8
negative ion	8
kanmx open	8
particle picking	8
defocus range	8
cprd gold	8
per condition	8
experimental procedures	8
structure analysis	8
squamous cell	8
shake flasks	8
min incubation	8
mpro ligands	8
nabae na	8
median ccn	8
asked whether	8
surface expression	8
confidence interval	8
lipid standards	8
oxygen consumption	8
exposed outside	8
supporting information	8
cells transfected	8
la ri	8
oxidized pdi	8
sphae ra	8
created using	8
determined purity	8
line encyclopedia	8
un id	8
imaging system	8
cul roc	8
specific activity	8
fems yeast	8
single cell	8
allowed us	8
national academy	8
virus production	8
icrocystis sp	8
data represents	8
active sites	8
made use	8
cpt activity	8
residual glucose	8
ligand concentration	8
mm nh	8
quantified using	8
polyclonal antibody	8
strains expressing	8
positive ion	8
gp il	8
patients prescribed	8
stat expression	8
reactions involving	8
sulfur metabolism	8
virus replication	8
dna glycosylases	8
polymix buffer	8
cellular redox	8
aeruginosa pc	8
precursor ion	8
cell rna	8
peck justice	8
nostoc lin	8
units ml	8
model using	8
sds sample	8
protein sci	8
polyclonal anti	8
terminal cysteines	8
molecular perturbations	8
closely related	8
goat anti	8
ethanol evaporation	8
johns hopkins	8
event times	8
nucleotides upstream	8
febs lett	8
oxidizing aa	8
cell type	8
polyacrylamide gel	8
hs binding	8
present address	8
er translocation	8
metabolic pathways	8
growth medium	8
differential gene	8
significant differences	8
change log	8
hi group	8
polyadenylation factor	8
using primers	8
clinical event	8
resting state	8
chem neurosci	8
tumor growth	8
lg unchanged	8
inhibitory effect	8
cell signaling	8
proteome res	8
cellulase cocktail	8
sds micelles	8
distinct roles	8
membrane complex	8
wt artemis	8
healthy controls	8
strains used	8
high levels	8
brilliant blue	8
antibody repertoire	8
damaged complex	8
arrows indicate	8
beta oligomers	8
hairpin opening	8
oh ring	8
lin ckia	8
zoom views	8
associated proteins	8
cysteine point	8
sec translocon	8
cell sci	8
gp gp	8
target recognition	8
based assay	8
mediated knockdown	8
ramachandran plot	8
experiments using	8
derived xenografts	8
nuclease assays	8
yeast res	8
nitric oxide	8
heart failure	8
coomassie brilliant	8
transgenic mice	8
associated protein	8
mchugh pj	8
unmapped headers	8
specific binding	8
negative feedback	8
cy fluorescence	8
energy metabolism	8
visualized using	8
rim pathway	8
idium sp	8
nuclease activity	8
reference manual	8
antibody sequences	8
ace hek	8
next investigated	8
unbound cytoplasmic	8
stop codon	8
standard error	8
secretory proteins	8
yeast species	8
cancer data	8
different days	8
jr pjr	8
cryoem map	8
electrostatic interactions	8
mrna target	8
analysis revealed	8
mm urea	8
id en	8
culture media	8
membrane lipoproteins	8
phosphate binding	8
pe ppe	8
relative abundance	8
endothelial dysfunction	8
newly identified	8
translation reactions	8
genetically engineered	8
hydrophobic residues	8
afm imaging	8
structural analyses	8
buchnera flagellum	8
croco sphae	8
done using	8
peptide constructs	8
washed times	8
pcr products	8
kinetic analysis	8
injection time	8
unknown general	8
control sirna	8
proteomics data	8
spectrometry analysis	8
quadruplet codons	8
conditionally essential	8
dynamic multiple	8
glcns glca	8
triplet anticodon	8
finger motif	8
particle cryo	8
using relion	8
supplementary data	8
based approach	8
sterol uptake	8
two biological	8
ab sciex	8
lb medium	8
serial dilutions	8
cycle arrest	8
open access	8
binary matrix	8
sec complex	8
patient tumor	8
pcr amplified	8
pos incubation	8
fc log	8
nh cl	8
abelein et	8
flanking sequences	8
garces et	8
ligand specificity	8
mediated disulfide	8
drugcodelist amitriptylinecodes	8
life science	8
ms spectra	8
pooling module	8
ehr data	8
octet red	8
helix peptides	8
second step	8
receptor complex	8
expressed genes	8
int ed	8
low ph	8
speed atomic	8
bulk rna	8
min time	8
normal glucose	8
synthetic lethal	8
cys hcy	8
th cells	8
ml pag	8
acid sequences	8
snap frozen	8
pisum sativum	8
experimental conditions	8
cerevisiae strains	8
diamond light	8
relatively low	8
nmr experiments	8
high affinity	8
query sample	8
flag rpn	8
biochemical characterization	8
abrahams jp	8
quantitative analysis	8
flagellum proteins	8
time interval	8
met cys	8
mm licl	8
lege cluster	8
pathogenic species	8
ppe linker	8
codon pairing	8
pseuda nabae	8
signal transduction	8
water interface	8
standard assay	8
based nuclease	8
different cell	8
tandem lesion	8
parameter set	8
dna recognition	8
ions display	8
cells lacking	8
si table	8
vitro reconstitution	8
strict anaerobic	8
strictly anaerobic	8
citrate synthase	8
proper folding	8
factor receptor	8
based proteomics	8
artemis protein	8
also showed	8
terminal regions	8
nr rnr	8
biomedical literature	8
residues involved	8
intramolecular quality	8
tris buffer	8
principal component	8
encoding cylc	8
stat signaling	8
linear gradient	8
rabbit polyclonal	8
terminal signal	8
protein abundance	8
molecular networking	8
open state	8
acid residues	7
em densities	7
protein stability	7
national science	7
charged residues	7
cysteine residue	7
mesh ewald	7
recognition site	7
sequences repeat	7
dna bound	7
gibson assembly	7
marxianus ims	7
diabetes mellitus	7
spring harb	7
gene clusters	7
la te	7
trigger samples	7
signal peptidase	7
complex assembly	7
bulleid nj	7
likely due	7
mm iptg	7
houben en	7
rna processing	7
mouse models	7
cys mutants	7
health record	7
cardiovascular disease	7
thece sp	7
enzyme subunits	7
relative absorbance	7
da nc	7
jiao tong	7
state trnas	7
conformational rearrangements	7
sp nies	7
flow column	7
tandem mass	7
mm potassium	7
head swiveling	7
terminal disordered	7
zhang et	7
following pos	7
bd biosciences	7
filam ento	7
duplication event	7
snapshots shown	7
study pjr	7
cell wall	7
effect size	7
first three	7
biol crystallogr	7
ori ampr	7
pa tk	7
nucleotides downstream	7
basal infoldings	7
res commun	7
sufb uses	7
factor samhd	7
genomics data	7
washed extensively	7
specific grn	7
homologous recombination	7
conformational change	7
glucose media	7
software program	7
reaction mixture	7
zn site	7
two independent	7
biological process	7
mtpp experiments	7
native mass	7
rix sp	7
new york	7
nat cell	7
commercially available	7
tumor suppressor	7
ace complex	7
recombinant proteins	7
huprp protein	7
van den	7
ch oh	7
us cyano	7
based metabolites	7
increased abundance	7
key residues	7
therapeutic strategies	7
internalisation degradation	7
atomic models	7
pdi molecules	7
may explain	7
binding modes	7
infect dis	7
two experiments	7
fetal bovine	7
mycobacterial esx	7
cryptic epitope	7
ml shake	7
total protein	7
model system	7
human prion	7
rnc molecules	7
yeast cell	7
acnash rdrugtrajectory	7
coli cells	7
ha ng	7
pansieri et	7
mitochondrial respiration	7
metabolomics data	7
pdi monomer	7
eluted using	7
ct io	7
ps ka	7
also included	7
melt curves	7
da silva	7
reference spectra	7
spike receptor	7
table containing	7
atlas research	7
synthetic medium	7
remains unknown	7
tk ai	7
aloth rix	7
preprint mailto	7
may interact	7
chro ococcidiop	7
internal standard	7
coq coq	7
eye institute	7
induced motion	7
mouse apobec	7
animal model	7
mass action	7
fc lo	7
dna replication	7
ubiquitination status	7
quaternary structure	7
ff sb	7
rigid body	7
clustering algorithm	7
resolution cryo	7
ugeot ii	7
cyano thece	7
snapshots captured	7
double mutant	7
mouse monoclonal	7
membrane fraction	7
graduate school	7
pdi dimer	7
nucleic acid	7
laboratory evolution	7
intrinsic disorder	7
met genes	7
like protein	7
cys native	7
promoted filaments	7
biologically relevant	7
class averages	7
primary antibody	7
amyloid fibrils	7
uranyl acetate	7
amyloid formation	7
significantly reduced	7
terminal half	7
like domains	7
mutational scanning	7
plos pathogens	7
treated cells	7
ethanol production	7
alis ccmee	7
systems biology	7
channel pore	7
alexa fluor	7
ssn cluster	7
vitro evolution	7
cysteine redox	7
erp gsh	7
ribosomal complexes	7
cprd data	7
individual nucleotides	7
specific prescription	7
healthcare life	7
legecc genomes	7
ion coordination	7
vitiligo patients	7
dna fragments	7
assay buffer	7
disulfide introduction	7
shanghai jiao	7
arbab et	7
tighter binding	7
ento us	7
aggregation assay	7
cytokine responses	7
hb levels	7
binding affinities	7
biological processes	7
limited number	7
prp protein	7
gp ko	7
lol sorting	7
secretion systems	7
cytokine receptors	7
tyr motifs	7
microarray data	7
ultrapure water	7
component analysis	7
simian immunodeficiency	7
chemical structure	7
figure extended	7
two amino	7
engineered mouse	7
tissue cell	7
ss ib	7
em maps	7
nutritional stress	7
reading frame	7
ebs analogs	7
throughput assay	7
whole cell	7
anaerobic workstation	7
results representative	7
preferential orientation	7
cov sars	7
decoding center	7
three replicates	7
min min	7
target genes	7
two major	7
biophys res	7
hydrolysis activity	7
key laboratory	7
ancestral sequences	7
oxygen species	7
proteasomal degradation	7
nm nm	7
du la	7
ring ubiquitin	7
kda met	7
lu st	7
different protein	7
infected cells	7
terminal residues	7
hopkins university	7
healthy control	7
proteolytic cleavage	7
model structure	7
length dhfr	7
comparative modeling	7
molecular simulations	7
intensive sites	7
showed significant	7
alzheimers dis	7
molecular devices	7
previous work	7
free energy	7
nar gkw	7
lit medium	7
pos degradation	7
clinical practice	7
see methods	7
based sequencing	7
using imagej	7
electrospray ionization	7
dual fragmentation	7
un da	7
protein sequence	7
data integrator	7
protein purification	7
particle mesh	7
amyloid aggregation	7
distance threshold	7
identity thresholds	7
samhd restriction	7
cterium lege	7
reactive oxygen	7
stdratio value	7
following manufacturer	7
visualization system	7
spike proteins	7
experiments showed	7
omega fatty	7
representative experiment	7
tag species	7
restriction sites	7
rapid kinetic	7
rm systems	7
indicated times	7
calcium ions	7
overall secondary	7
specific interactions	7
resolution structure	7
using graphpad	7
st er	7
wt rim	7
chemical biology	7
complex recruitment	7
resonance irradiation	7
arabidopsis thaliana	7
covalent inhibitors	7
der laan	7
accessible surface	7
limited conditions	7
ru rc	7
animal models	7
rheumatoid arthritis	7
cells treated	7
data using	7
wb analysis	7
luciferase assay	7
funding acquisition	7
important structural	7
aggregation half	7
kcal mol	7
protein sequences	7
reservoir solution	7
proteomic analysis	7
secondary antibody	7
transcript levels	7
also used	7
cell suspensions	7
fibrillar aggregates	7
molecular cloning	7
bactron anaerobic	7
prescription prodcode	7
values generated	7
virus type	7
bromoenol lactone	7
chain complex	7
nmr data	7
cluster sizes	7
recombinant protein	7
status labels	7
coli strains	7
human body	7
molecular interactions	7
sis sp	7
ab un	7
human umbilical	7
treated biomass	7
nat protoc	7
dna backbone	7
pylori strain	7
significantly enriched	7
molecular level	7
parent ion	7
prescription records	7
recorded using	7
repeated twice	7
copy number	7
potent neutralizing	7
first time	7
rate constants	7
expression patterns	7
sulfur metabolic	7
metabolite levels	7
ionic strength	7
cell res	7
signal sequences	7
chemical structures	7
cultured human	6
parameters used	6
protein residues	6
nmr assays	6
conjugation machinery	6
cell mol	6
curve fitting	6
one day	6
alkaline pre	6
dna rna	6
cytokine stimulation	6
levels induced	6
row names	6
prescription prodcodes	6
minority classes	6
germ cell	6
therapy data	6
gp wt	6
du ct	6
variability analysis	6
endometrial cancer	6
medicinal chemistry	6
triglyceride lipase	6
ap mutation	6
via immunoblotting	6
cell receptor	6
pronk tudelft	6
also supplementary	6
karim et	6
genome res	6
atg pcag	6
methods protein	6
peaks represent	6
ec domain	6
diffusion method	6
rna pol	6
pskai proteins	6
watso nii	6
tetrameric assemblage	6
total il	6
spike trimer	6
protein degradation	6
nat chem	6
high performance	6
hydroxamic acid	6
functional characterization	6
see fig	6
estimated using	6
insect stages	6
sulfur metabolite	6
used immediately	6
afm movies	6
primary antibodies	6
nat prod	6
subunit domain	6
based model	6
analysis identified	6
fold increase	6
final concentrations	6
three variants	6
cleaved gp	6
conserved across	6
hpse treatment	6
study psc	6
acta neuropathol	6
rev biochem	6
mm atp	6
tiiman et	6
exponential phase	6
two additional	6
chagas disease	6
activity assays	6
cystis sp	6
reaction buffer	6
metabolic stress	6
university school	6
exit tunnel	6
pstat kinetics	6
patricia becerra	6
clinical data	6
hs oligosaccharides	6
ro sp	6
non normal	6
mm acetate	6
unphosphorylated stat	6
clinical notes	6
sequence identity	6
cell lung	6
na hpo	6
driver mutations	6
overnight incubation	6
jak stat	6
chain disulfide	6
complexes containing	6
bond angles	6
energy collision	6
nt ia	6
copper metabolism	6
orf proteins	6
better understand	6
internal fatty	6
wide association	6
dna cleavage	6
receptor complexes	6
unchanged regulated	6
oxygen limitation	6
excision repair	6
associated metabolite	6
lipoprotein maturation	6
psc pam	6
reported previously	6
also possible	6
pcr reactions	6
step bleaching	6
gwas central	6
comput chem	6
cytometry analysis	6
native gp	6
es po	6
studies using	6
respiratory syncytial	6
highest ccn	6
induced lc	6
ae ro	6
rm op	6
ng ml	6
catalyzed disulfide	6
sdh sdh	6
host genome	6
species based	6
expression analysis	6
thereby preventing	6
monomeric form	6
tertiary structure	6
living cells	6
autophagosome biogenesis	6
cpf trigger	6
ad pathology	6
also shown	6
protein samples	6
molecular determinants	6
mm palmitate	6
irf sirna	6
complex formation	6
od units	6
reducing conditions	6
human antibody	6
sars coronavirus	6
de villartay	6
elution window	6
sirna irf	6
curr opin	6
containing pure	6
umbilical vein	6
new tools	6
assays using	6
helpful discussions	6
assessed using	6
bayes factor	6
cells expressed	6
parameter values	6
query samples	6
take place	6
ncbi reference	6
tof ms	6
specific hs	6
approved drugs	6
wildtype shown	6
cox js	6
crystallographic screening	6
bipolar disorder	6
binding assay	6
translation elongation	6
rhodopsin degradation	6
tested whether	6
bonded species	6
rpe choroid	6
po ns	6
virus infection	6
variable retention	6
ium lege	6
ra watso	6
proteins detected	6
closed states	6
two enzymes	6
abbreviations used	6
mrna targets	6
gsea reactome	6
systematic review	6
artemis catalytic	6
images taken	6
gp inner	6
closed conformation	6
ii transcription	6
secondary structures	6
ad brains	6
variable loops	6
break repair	6
acyl chain	6
throughput screening	6
three models	6
vein endothelial	6
base pairs	6
go analysis	6
optn triggered	6
accession number	6
ab initio	6
gbp gbp	6
human serum	6
data distribution	6
cholesterol transport	6
nominal magnification	6
target protein	6
research institute	6
preprint http	6
spacer length	6
dna interactions	6
image analysis	6
oxidative phosphorylation	6
pseudotyped viruses	6
em density	6
en tif	6
es se	6
json format	6
competition experiments	6
nucleotides surrounding	6
met binding	6
cnrs umr	6
oxog lesion	6
met protein	6
min post	6
ims kmpdc	6
interaction energy	6
syncytial virus	6
gender ami	6
cov spike	6
beneficial effects	6
functional analysis	6
analytical signal	6
luciferase activity	6
peptide cysteine	6
cellular copper	6
md simulation	6
appropriate fractions	6
iii pks	6
geitler inema	6
viral protein	6
lol system	6
several studies	6
conditional genetic	6
docosahexaenoic acid	6
synthetic recombinant	6
dominant subgroup	6
rabbit reticulocyte	6
attachment factor	6
positive mode	6
results demonstrate	6
amplified using	6
editing activity	6
substantial differences	6
scatter plot	6
go term	6
structural isomers	6
technical triplicates	6
multivariable model	6
buchnera cells	6
proteins involved	6
liquid ethane	6
cysteine pair	6
model performance	6
fourier shell	6
collected using	6
dna complexes	6
total number	6
significantly higher	6
acid levels	6
salt bridge	6
mutual information	6
bayes factors	6
facing dc	6
bond lengths	6
gade malmos	6
filaments derived	6
powell et	6
rich media	6
almost identical	6
ph ae	6
gp signal	6
carbon source	6
light green	6
em analysis	6
time pcr	6
physiological responses	6
hb release	6
sp buffer	6
tumor cells	6
nitrocellulose membrane	6
germain et	6
nl https	6
collision dissociation	6
either side	6
ms spectrum	6
dna mutation	6
purified proteins	6
relative incompatibility	6
core complexes	6
different cancer	6
cancer subtypes	6
point mutants	6
ra patients	6
infrared spectroscopy	6
pichia pastoris	6
dose response	6
zhou et	6
enzymatic assays	6
peptide reads	6
methods section	6
one subunit	6
health records	6
lipid accumulation	6
test wt	6
initial concentration	6
th nucleotide	6
labelled cancer	6
phenol red	6
glucose metabolism	6
nm atg	6
flag complex	6
neurodegenerative disorders	6
fluorescence signal	6
erp pdi	6
national eye	6
ebs oxide	6
gravity flow	6
complementation factor	6
true mbls	6
yeast saccharomyces	6
salt solution	6
coronavirus neutralization	6
lead contact	6
comparative analysis	6
plot showing	6
column volumes	6
line treatment	6
primer pairs	6
testtherapydf prodcode	6
substrate receptor	6
filaments extracted	6
transduced cells	6
piton et	6
proteomics core	6
regulated genes	6
significantly altered	6
robinson et	6
movies showing	6
significantly increased	6
initial structure	6
shell correlation	6
corresponding authors	6
bottom panel	6
sensitized screen	6
regulatory networks	6
exploratory research	6
immunoreactive proteins	6
antimicrobial peptides	6
gender prop	6
zinc fingers	6
loop structure	6
life cycle	6
inema sp	6
buffered saline	6
mg tablet	6
experimental system	6
pos ml	6
mesenchymal stem	6
overall resolution	6
duplex bound	6
ribosomal subunit	6
normal targeting	6
modulated proteins	6
terminal truncations	6
ho coc	6
cell growth	6
globular domain	6
macromolecular structure	6
protein aggregates	6
zn ions	6
viral infection	6
data obtained	6
aggregate clumps	6
temperature treatment	6
cancer peaks	6
key words	6
stat levels	6
rpe gp	6
shared total	6
least three	6
medical history	6
polar residues	6
viral proteins	6
genes dev	6
sirna control	6
white arrows	6
higher efficiency	6
baddock et	6
total volume	6
acidic residues	6
attachment site	6
gu la	6
owen et	6
glucose concentration	6
limited cultures	6
cerevisiae imx	6
light onset	6
dtt dtt	6
genetic dependencies	6
intracellular atp	6
lung tissue	6
tablet oral	6
lipid class	6
sequence information	6
studies showed	6
evaluated using	6
black box	6
formation assay	6
genes downregulated	6
free protease	6
wt gp	6
isolation procedure	6
building tools	6
highly similar	6
used candi	6
patid unlist	6
lc conjugation	6
reduced signal	6
additional clinical	6
derived peptides	6
cysteine oxidation	6
uniform refinement	6
molecule inhibitors	6
atp levels	6
aspergillus fumigatus	6
fl fl	6
lipid research	6
statistical methods	6
silac media	6
cd cd	6
gf column	6
host cells	6
alamar blue	6
freely available	6
espb monomer	6
expanded anticodon	6
lan et	6
pmc articles	6
classification profile	6
acting elements	6
see legend	6
affinity binding	6
nature methods	6
filter pads	6
two steps	6
mm ammonium	6
tif ie	6
dna extraction	6
se nt	6
dotted line	6
ifit ifit	6
accession codes	6
carnitine palmitoyltransferase	6
glutathione metabolism	6
previously developed	6
autophagy components	6
signal anchor	6
tumor samples	6
fold nucleases	6
simulation time	6
recent studies	6
significant increase	6
nature biotechnology	6
obacte rium	6
gbp stat	6
aminobenzoic acid	6
significant difference	6
composite score	6
glcnac glca	6
tested substrates	6
clinical trials	6
ecd tmd	6
life sci	6
elution buffer	6
use cases	6
nitronate monooxygenase	6
radiolabelled products	6
fuzzy matching	6
also revealed	6
exonuclease activity	6
monomer form	6
oxog extrusion	6
receptor chain	6
experiments performed	6
may play	6
surface display	6
oxidative protein	6
protein structures	6
pa pc	6
first drug	6
cytoplasmic phosphorylated	6
multivariable linear	6
genbank accession	6
foreign dna	6
using standard	6
commercial software	6
okumura et	6
early stages	6
similar results	6
cellular processes	6
genomic context	6
neutralizing human	6
proteins present	6
spring harbor	6
genes coding	6
biosynthetic gene	6
elongation factor	6
mg tablets	6
cancer biology	6
repeat peaks	6
outer membranes	6
uses triplet	6
box size	6
methods mol	6
human antibodies	6
foster city	6
showing key	6
study suggests	6
fi la	6
showed similar	6
binding energy	6
dna sequencing	6
regression models	6
real time	6
deep mutational	6
virulence factor	6
met ip	6
mechanistic insights	6
membrane lipoprotein	6
previously published	6
different types	6
core autophagy	6
ori camr	6
low sulfur	6
associated codons	6
co re	6
residues within	6
buffer supplemented	6