trigram

This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

trigram	frequency
as well as	1259
the presence of	1068
in order to	896
in this study	708
one of the	664
the development of	621
the effect of	573
in the presence	551
the use of	484
the treatment of	479
the effects of	464
based on the	444
results suggest that	439
the synthesis of	437
the role of	431
found to be	431
the present study	422
the expression of	405
the activity of	403
due to the	401
involved in the	389
the aim of	379
activity of the	374
was found to	373
the formation of	369
on the other	361
it has been	357
in the present	350
the other hand	349
to investigate the	345
a series of	336
compared to the	332
the number of	331
the production of	321
these results suggest	312
a number of	299
role in the	294
of this study	287
for the treatment	283
we found that	281
is one of	274
of the most	263
in vitro and	261
study was to	260
a variety of	259
this study was	259
in patients with	258
can be used	253
the mechanism of	250
been shown to	248
isolated from the	248
an important role	247
in addition to	246
according to the	242
in terms of	239
as a result	236
and in vivo	234
have shown that	230
were found to	229
important role in	227
vitro and in	224
has been shown	222
the regulation of	222
to determine the	221
to be a	216
suggest that the	213
the activation of	213
analysis of the	212
to that of	210
aim of this	210
an increase in	209
showed that the	209
part of the	208
the level of	207
mechanism of action	205
by means of	205
as compared to	203
the results of	200
to study the	199
well as the	198
responsible for the	198
used as a	195
of the protein	194
graduate school of	193
structure of the	192
of the peptide	191
the importance of	188
the inhibition of	183
there is a	183
shown to be	183
antiviral activity of	181
was used to	181
changes in the	179
wide range of	178
results indicate that	178
antimicrobial activity of	177
the case of	176
is involved in	174
the structure of	174
in response to	174
are involved in	173
in the brain	173
the absence of	173
the growth of	173
the most potent	170
we investigated the	169
the influence of	168
in the treatment	167
most of the	167
the amount of	167
in this work	167
of mannich bases	166
in the case	165
some of the	164
to evaluate the	163
was supported by	162
in contrast to	162
be involved in	162
of these compounds	161
a wide range	161
mannich bases of	160
results showed that	158
increase in the	158
the ability of	157
and in the	156
have been reported	154
effect on the	153
cancer cell lines	152
found in the	152
this work was	152
was carried out	152
related to the	150
the ability to	149
used for the	149
found that the	149
school of medicine	148
such as the	148
in which the	148
than that of	148
of action of	148
associated with the	148
observed in the	147
for the synthesis	147
used in the	146
to be the	145
activity in the	145
in the same	145
the design of	144
the most active	144
has been reported	144
mode of action	143
a role in	142
it was found	142
activation of the	142
the addition of	142
antibacterial activity of	141
reactive oxygen species	140
is associated with	140
a and b	140
effect of the	139
of the enzyme	139
for the development	138
the active site	138
we examined the	137
with respect to	137
in the absence	135
effects of the	135
the identification of	135
be used as	133
the application of	133
a result of	132
the levels of	132
the in vitro	132
depending on the	132
known to be	131
compared with the	130
will be presented	130
in the development	130
that of the	130
is based on	130
be used to	130
play an important	130
central nervous system	129
biological activity of	129
were able to	128
the interaction of	128
the fact that	128
neurons in the	128
was used as	128
the basis of	127
been reported to	127
in combination with	127
the most common	127
we show that	126
in the regulation	126
contribute to the	126
was observed in	126
was found that	126
the majority of	125
and in vitro	124
expression of the	124
due to its	124
and characterization of	124
amino acid residues	124
is known to	124
will be discussed	123
were used to	123
was shown to	122
due to their	122
the control group	122
to understand the	122
the function of	121
is the most	121
of the compounds	120
the first day	120
at the same	119
cells in the	119
that can be	119
resulted in a	119
more potent than	118
seems to be	118
properties of the	117
has been used	117
the binding of	117
in the range	116
the release of	116
presence of a	116
is an important	116
the study of	116
were carried out	116
of the two	116
revealed that the	115
of the cell	115
has also been	115
herpes simplex virus	114
which is a	114
because of the	113
on the basis	113
was determined by	112
role of the	112
in comparison to	112
the range of	112
the control of	112
these results indicate	111
well as in	110
a range of	110
which can be	110
large number of	110
the end of	110
we conclude that	110
the amino acid	110
present in the	109
are known to	109
at the c	109
the surface of	109
we have shown	109
of the human	109
is essential for	109
a decrease in	109
their ability to	108
presence of the	108
the relationship between	107
of patients with	107
aim of the	107
are able to	107
the most important	106
in the study	106
proved to be	105
there was no	105
the process of	105
show that the	105
the impact of	105
has not been	105
the plasma membrane	104
supported by the	104
inhibition of the	104
the rate of	103
understanding of the	103
to identify the	102
position of the	102
the detection of	102
mechanisms of action	102
results show that	101
the pathogenesis of	101
the antiviral activity	101
in the rat	101
work was supported	101
shown that the	101
indicate that the	101
be used for	101
expressed in the	101
the nature of	100
of amino acids	100
the analysis of	100
this study is	99
studies showed that	99
play a role	99
for the first	99
a combination of	99
in a dose	99
the concentration of	99
when compared to	98
was to investigate	98
it was shown	97
of psoralea corylifolia	97
be used in	96
were treated with	96
a set of	96
have been used	96
of the present	96
the discovery of	96
the introduction of	96
function of the	96
studies have shown	95
have been shown	95
antiviral activity against	95
the same time	95
we aimed to	95
the induction of	95
to increase the	95
led to the	94
antifungal activity of	94
is required for	94
the purpose of	94
is able to	94
there is no	94
nature of the	93
to improve the	93
of a new	93
present study was	93
in the control	93
inhibitory activity against	92
demonstrated that the	92
in recent years	92
the interaction between	91
a large number	91
the lack of	91
it is possible	91
all of the	91
characterization of the	91
study is to	91
in the last	90
were isolated from	90
on the surface	90
member of the	90
be due to	90
the first time	90
data suggest that	90
were determined by	89
a total of	89
compared to control	88
inhibitory activity of	88
indicated that the	88
it can be	88
did not show	87
a concentration of	87
plays an important	87
the results showed	87
bases derived from	87
the antibacterial activity	87
derived from the	86
different types of	86
the generation of	86
the biological activity	86
it is a	86
we have developed	86
studies on the	86
is responsible for	86
focused on the	85
this study we	85
mannich bases derived	85
differences in the	85
to inhibit the	85
to elucidate the	85
the action of	85
our results suggest	85
of essential oils	85
the th day	85
antioxidant activity of	84
evaluation of the	84
to assess the	84
but not in	84
at the end	83
as a model	83
of the peptides	82
a mixture of	82
at a concentration	82
of a novel	82
to examine the	82
similar to that	82
the involvement of	82
was shown that	81
reported to be	81
in vivo and	81
materials and methods	81
for treatment of	81
of the c	81
was found in	81
decrease in the	80
end of the	80
the efficacy of	80
in the human	80
and can be	80
to be more	80
amino acid sequence	80
to the first	80
of the n	80
the combination of	80
to reduce the	80
the course of	80
the preparation of	80
have been identified	80
the increase in	79
the evaluation of	79
were found in	79
been found to	79
binding to the	79
is known about	79
were observed in	79
a group of	79
was the most	79
may contribute to	79
appears to be	79
the possibility of	79
have been found	78
the central nervous	78
have also been	78
we report the	78
rna chaperone activity	78
obtained from the	78
could be used	78
are associated with	77
effects on the	77
in the first	77
the cell membrane	77
there was a	77
to be involved	77
suggested that the	77
region of the	76
we showed that	76
based on a	76
the present work	76
and mg kg	76
amino acids and	75
is the first	75
regulation of the	75
results indicated that	75
this is the	75
we have previously	75
components of the	75
members of the	75
has been found	75
be able to	75
in the cell	75
in the literature	74
dependent on the	74
the risk of	74
a member of	74
in case of	74
of the study	74
the frequency of	74
results of the	74
phase peptide synthesis	74
inhibitory effect of	74
the determination of	73
have been developed	73
be related to	73
and evaluation of	73
interaction with the	73
been shown that	73
hepatitis c virus	73
for this purpose	73
carried out in	73
of the essential	72
the immune system	72
led to a	72
be responsible for	72
development of new	72
from the marine	72
the study was	72
was isolated from	72
in this context	72
were used for	71
oxidative stress and	71
in the pathogenesis	71
suggests that the	71
depends on the	71
to play a	71
study of the	71
signi fi cantly	71
in comparison with	71
a dose of	71
suggesting that the	71
and biological evaluation	70
the mechanisms of	70
the molecular mechanisms	70
little is known	70
the cell surface	70
university of tokyo	70
some of these	70
of mg kg	70
and it is	70
investigation of the	70
synthesis and biological	70
were shown to	70
of the same	70
may be a	70
is expressed in	70
mechanism of the	70
in our study	69
department of physiology	69
the degree of	69
are responsible for	69
active site of	69
for the production	69
the compounds were	69
activity of a	69
a key role	69
it is also	69
which is the	69
antibacterial activity against	69
development of a	69
formation of the	69
change in the	68
required for the	68
the activities of	68
considered to be	68
addition to the	68
of the major	68
did not affect	68
the synthesis and	68
phenolic mannich bases	68
activity against the	67
biological evaluation of	67
an increase of	67
at position of	67
also known as	67
we developed a	67
activities of the	67
was used for	67
been used to	67
to interact with	67
similar to the	67
key role in	67
gene expression in	67
is thought to	67
lead to the	67
at a dose	66
is a major	66
in the hippocampus	66
breast cancer cells	66
in the central	66
the stability of	66
be associated with	66
it is known	66
of these peptides	66
inhibitory effect on	66
new class of	66
no effect on	66
stability of the	66
essential for the	65
none of the	65
to those of	65
use of the	65
to analyze the	65
with ic values	65
in relation to	65
is used to	65
some of them	65
science and technology	65
of reactive oxygen	65
can also be	65
marine natural products	65
was able to	65
thought to be	65
the changes in	65
by using the	65
characterized by a	65
is important for	64
of our study	64
we studied the	64
findings suggest that	64
of the target	64
as shown in	64
we analyzed the	64
the most effective	64
the results suggest	64
were used as	64
activity of these	64
determination of the	64
formation of a	64
found to have	64
the onset of	63
comparison of the	63
national institute of	63
to the control	63
in vitro activity	63
for the design	63
the distribution of	63
the wild type	63
located in the	63
the antioxidant activity	63
because of their	63
the loss of	63
significant increase in	63
is characterized by	63
low molecular weight	63
the potential of	63
oral administration of	62
aim of our	62
the results obtained	62
in our laboratory	62
to be used	62
is related to	62
a significant increase	62
and its derivatives	62
belongs to the	62
here we report	62
crystal structure of	62
we have recently	62
the increase of	62
in presence of	62
of the viral	62
activity in vitro	62
carried out by	61
of natural products	61
the university of	61
ic value of	61
structures of the	61
blood samples were	61
the type of	61
day compared to	61
have not been	61
caused by the	61
an in vitro	61
than in the	61
ic values of	61
between the two	61
it is not	61
a family of	60
tumor necrosis factor	60
the context of	60
in situ hybridization	60
we were able	60
are the most	60
amino acids in	60
results suggested that	60
of pomegranate juice	60
the potential to	60
for the detection	60
and on the	60
were obtained from	60
were analyzed by	59
we are currently	59
of the virus	59
the existence of	59
important for the	59
importance of the	59
were the most	59
as the most	59
human immunodeficiency virus	59
development of the	59
at the n	59
of this work	59
leads to the	59
the proliferation of	59
as a consequence	59
were synthesized by	59
leading to the	59
was associated with	59
the extent of	59
with regard to	59
with an ic	59
that have been	59
has been demonstrated	59
that there is	58
of the proteins	58
isolated from a	58
was detected in	58
information on the	58
were tested for	58
of the amino	58
residues in the	58
was measured by	58
the essential oil	58
cell death in	58
results in the	58
to clarify the	58
reduction of the	58
serve as a	58
dose of mg	58
and that the	58
before and after	58
to characterize the	58
method for the	58
is a potent	58
was added to	58
increase of the	57
added to the	57
the antimicrobial activity	57
acts as a	57
in the past	57
the mannich reaction	57
together with the	57
the most promising	57
were detected in	57
the in vivo	57
due to a	57
interact with the	57
the accumulation of	57
we propose that	57
the search for	57
followed by a	57
expression in the	57
of punica granatum	57
signi fi cant	57
when compared with	56
resulted in the	56
studies of the	56
by using a	56
molecular mechanisms of	56
to have a	56
is possible to	56
in the field	56
associated with a	56
as a potential	56
and biological activity	56
of a series	56
of cordyceps sinensis	56
consistent with the	56
is a key	56
we have investigated	55
synthesis of a	55
in the context	55
synthesis of the	55
had no effect	55
detected in the	55
oxidative stress in	55
the characterization of	55
comparable to that	55
of the membrane	55
to the presence	55
that it is	55
and antimicrobial activity	55
of gene expression	55
reported that the	55
broad spectrum of	55
we have identified	55
of the activity	55
mg kg day	55
linked to the	55
purpose of this	55
a crucial role	55
is due to	55
only in the	54
of antimicrobial peptides	54
in the formation	54
is important to	54
data indicate that	54
the sequence of	54
is mediated by	54
basis of the	54
of reference drug	54
is known that	54
of the cells	54
of amino acid	54
control of the	54
with that of	54
attached to the	54
and found that	54
from psoralea corylifolia	54
was applied to	54
parts of the	54
we used the	54
high levels of	54
is composed of	54
the cytotoxicity of	54
of the first	54
in the liver	53
correlated with the	53
to test the	53
showed the highest	53
it should be	53
m g ml	53
corresponding to the	53
hepatitis b virus	53
was confirmed by	53
of the active	53
i and ii	53
biological activities of	53
to the development	53
have demonstrated that	53
to be an	53
a new class	53
levels of the	53
surface of the	53
may lead to	53
of the disease	53
the form of	53
in the mouse	53
indicating that the	53
could be a	53
solid phase peptide	53
was performed by	53
academy of sciences	53
protective effect of	53
were performed in	53
each of the	53
diseases such as	53
the reduction of	53
composition of the	53
expression levels of	52
analysis revealed that	52
are present in	52
part of a	52
a reduction in	52
than reference drug	52
it is well	52
and synthesis of	52
the essential oils	52
there were no	52
in the form	52
to explore the	51
in some cases	51
of the compound	51
vivo and in	51
of more than	51
reduction in the	51
activity of some	51
were exposed to	51
sequence of the	51
in escherichia coli	51
significantly higher in	51
on the cell	51
that in the	51
leads to a	51
these findings suggest	51
in the future	51
and function of	51
the need for	51
the reaction of	51
was assessed by	51
as in the	51
insight into the	51
able to inhibit	51
has been proposed	51
the incidence of	50
used as an	50
to develop a	50
has been developed	50
the fi rst	50
group of the	50
is regulated by	50
the seeds of	50
ability to inhibit	50
antifungal activity against	50
western blot analysis	50
cancer cell line	50
activity of mannich	50
characterization of a	50
the position of	50
many of the	50
more active than	50
the current study	50
to the cell	50
the result of	50
included in the	50
we have used	50
the inhibitory effect	50
in the synthesis	50
we have found	50
belonging to the	50
based on these	50
of the three	50
appear to be	50
it is important	50
with a high	49
university graduate school	49
be considered as	49
protein kinase c	49
be useful in	49
be the most	49
interaction of the	49
designed and synthesized	49
have been isolated	49
of in vitro	49
higher than that	49
of the test	49
potent inhibitors of	49
to the formation	49
antimicrobial activity against	49
wide variety of	49
have to be	49
differences between the	49
department of chemical	49
be attributed to	49
aimed to investigate	49
in a variety	49
in the early	49
is used as	49
used to treat	49
and development of	48
modification of the	48
the investigation of	48
been associated with	48
a consequence of	48
analysis was performed	48
contrast to the	48
a panel of	48
in the adult	48
recent studies have	48
as compared with	48
and of the	48
in vitro studies	48
is caused by	48
crucial role in	48
tested for their	48
has been suggested	48
antibacterial and antifungal	48
results of this	48
our results show	48
stimulation of the	48
the ratio of	48
contributes to the	48
physical activity and	48
on the first	48
were synthesized and	48
the incorporation of	47
the performance of	47
were measured by	47
were significantly higher	47
of this enzyme	47
influence of the	47
inhibitory effects of	47
here we present	47
been isolated from	47
the time of	47
we used a	47
knowledge of the	47
activity was observed	47
the size of	47
of the main	47
as a novel	47
more than of	47
likely to be	47
important roles in	47
the conversion of	47
the isolation of	47
peptides and proteins	47
positive and gram	47
to form a	47
which could be	47
as determined by	47
has to be	47
as amine reagents	47
of the tested	47
state of the	47
the united states	47
the hydrolysis of	47
mutations in the	46
learning and memory	46
major role in	46
in vitro anti	46
no significant difference	46
as a new	46
cells of the	46
one or more	46
by the presence	46
may play a	46
we have studied	46
of the new	46
was performed using	46
to be effective	46
and has been	46
antimicrobial activities of	46
was investigated by	46
insights into the	46
were used in	46
site of the	46
the value of	46
inhibitors of the	46
the replication of	46
of the gene	46
induced by the	46
component of the	46
we have also	46
is well known	46
point of view	46
we present the	46
an inhibitor of	46
higher than the	46
of them are	45
step in the	45
university school of	45
a part of	45
the first step	45
of the plant	45
characteristics of the	45
applied to the	45
length of the	45
in this series	45
have investigated the	45
the cells were	45
institute of technology	45
seem to be	45
are used in	45
there is an	45
that the presence	45
study was supported	45
resulting in the	45
and inhibition of	45
these compounds were	45
a wide variety	45
in the process	45
the quality of	45
known about the	45
as part of	45
activity against a	45
and some of	45
have been studied	45
the results indicated	45
p and p	45
can be applied	45
smooth muscle cells	45
its ability to	45
binding of the	45
shown to have	45
we demonstrated that	45
but also in	44
the last years	44
could not be	44
in the blood	44
of eucalyptus camaldulensis	44
and may be	44
and identification of	44
of the brain	44
concentrations of the	44
which may be	44
out of the	44
in the current	44
allowed us to	44
genes involved in	44
for use in	44
the inhibitory activity	44
group at the	44
at room temperature	44
li et al	44
the possibility to	44
and the other	44
amino acid sequences	44
not only in	44
as inhibitors of	44
the rhizomes of	44
that has been	44
tandem mass spectrometry	44
pomegranate fruit extract	44
also in the	44
in the active	44
that of reference	44
psoralea corylifolia l	44
levels in the	44
action of the	44
the structure and	44
structure and function	44
molecular weight of	44
were incubated with	44
results demonstrate that	44
the length of	44
structural and functional	44
a critical role	44
of the different	44
a broad spectrum	44
was evaluated by	43
regions of the	43
expression level of	43
may be involved	43
this class of	43
work was to	43
concentration of the	43
were subjected to	43
which has been	43
at least one	43
synthesized a series	43
a class of	43
proven to be	43
analysis showed that	43
the mode of	43
a model of	43
been used as	43
in accordance with	43
results revealed that	43
implicated in the	43
of physical activity	43
of the patients	43
removal of the	43
an attempt to	43
the secondary structure	43
cell proliferation and	43
because of its	43
department of chemistry	43
the tested compounds	43
were divided into	43
molecular dynamics simulations	43
the interaction with	43
relationship between the	43
respect to the	43
is crucial for	43
may be useful	43
domain of the	43
the concept of	43
in agreement with	43
the synthesized compounds	43
the crystal structure	42
the hypothesis that	42
the modulation of	42
we present a	42
breast cancer cell	42
these data suggest	42
an ic value	42
were obtained by	42
mediated by the	42
data on the	42
this type of	42
of biological activities	42
in the second	42
result of the	42
in spite of	42
potent and selective	42
order to investigate	42
were performed on	42
the spinal cord	42
the contribution of	42
half of the	42
two types of	42
synthesis of novel	42
need to be	42
is present in	42
proteins involved in	42
on the activity	42
influence on the	42
in the developing	42
be useful for	42
of the rat	42
was studied in	42
severe acute respiratory	42
those of the	42
been used for	42
of the interaction	42
compared to that	42
in animal models	42
is necessary to	42
was expressed in	42
is dependent on	42
needs to be	41
values in the	41
to obtain the	41
the objective of	41
surface plasmon resonance	41
the results were	41
activities in the	41
to bind to	41
of the complex	41
based on their	41
a major role	41
been used in	41
the percentage of	41
of the dna	41
is the major	41
design and synthesis	41
was performed in	41
activity and the	41
it was also	41
peptides derived from	41
in this review	41
the age of	41
this work is	41
were investigated in	41
during the first	41
correlation between the	41
present study we	41
for the study	41
and activation of	41
higher in the	41
in the following	41
ability of the	41
can lead to	41
the composition of	41
under the control	41
the field of	41
are essential for	41
and it was	41
than those of	41
the cell cycle	41
acute respiratory syndrome	41
close to the	41
this work we	41
a decrease of	41
our results indicate	41
we observed that	41
a reduction of	40
size of the	40
well as a	40
difference in the	40
have been synthesized	40
at the level	40
the antifungal activity	40
here we show	40
the biosynthesis of	40
nitric oxide synthase	40
it was observed	40
interest in the	40
the management of	40
a source of	40
children and adolescents	40
studies have been	40
appeared to be	40
a period of	40
to reference drug	40
and as a	40
in a single	40
activity against m	40
prostate cancer cells	40
investigated the effects	40
used to determine	40
expressed in e	40
attributed to the	40
aim is to	40
was induced by	40
were more potent	40
the structures of	40
is part of	40
levels were measured	40
synthesis and in	40
are used as	40
of a single	40
to enhance the	40
was designed to	40
the effectiveness of	40
is that the	40
of a protein	40
a review of	40
application of the	40
of chemical engineering	40
we suggest that	40
from patients with	40
high degree of	40
brain science institute	40
were identified by	40
we have been	39
the uptake of	39
wang et al	39
characterized by the	39
as one of	39
the enzyme activity	39
we demonstrate that	39
department of molecular	39
the possibility that	39
are expressed in	39
kg body weight	39
been reported that	39
to obtain a	39
simplex virus type	39
with the use	39
indicates that the	39
potential of the	39
were determined in	39
have developed a	39
lee et al	39
were compared with	39
by mass spectrometry	39
levels were significantly	39
similar to those	39
significant differences in	39
have been described	39
on the use	39
to determine whether	39
more than one	39
the properties of	39
interaction between the	39
the results show	39
was observed for	39
spinal cord injury	39
reported in the	39
in vitro antiviral	39
of the total	39
increased in the	39
with those of	39
interactions between the	39
in vivo studies	39
in cell culture	39
of the a	39
small number of	39
have found that	39
pharmakologie und toxikologie	39
of the synthesized	39
is supported by	39
carried out on	39
the kinetics of	39
compounds were tested	39
in this way	39
identification of the	39
roles in the	38
the group of	38
of these proteins	38
are found in	38
of at least	38
pomegranate seed oil	38
was investigated in	38
considered as a	38
lower than that	38
there are several	38
of the molecule	38
is necessary for	38
and the lowest	38
level of the	38
in most cases	38
values of the	38
from a marine	38
in the production	38
most of them	38
were investigated by	38
to reveal the	38
to be active	38
investigated the effect	38
conclude that the	38
enzymes involved in	38
necessary for the	38
the toxicity of	38
were prepared by	38
along with the	38
at least in	38
the rest of	38
inhibit the growth	38
the yoghurt sample	38
and for the	38
majority of the	38
not affect the	38
of them were	38
are thought to	38
ketonic mannich bases	38
punica granatum l	38
we report that	38
difference between the	38
affected by the	38
human umbilical vein	38
in the series	38
better understanding of	38
critical role in	38
broad range of	38
in the course	38
in breast cancer	38
found to inhibit	38
in an attempt	38
in the number	38
a function of	38
reported to have	38
are characterized by	38
of all the	38
has been identified	38
compared to those	38
was inhibited by	37
that may be	37
in the nucleus	37
a lack of	37
the aromatic ring	37
of molecular biology	37
results in a	37
were expressed in	37
in this case	37
in the n	37
in regulation of	37
performance liquid chromatography	37
in physical activity	37
for in vitro	37
of the molecular	37
of the antimicrobial	37
c and c	37
its interaction with	37
to be able	37
the interactions between	37
risk factor for	37
the removal of	37
the protein was	37
a significant decrease	37
are based on	37
to compare the	37
factors such as	37
is a novel	37
national institute for	37
molecular mechanism of	37
of these two	37
for this reason	37
which have been	37
department of biology	37
of the genus	37
the basis for	37
and the results	37
polymerase chain reaction	37
potent inhibitor of	37
was higher than	37
we focused on	37
of the central	37
of the native	37
in mammalian cells	37
in the plasma	37
for the activity	37
but it is	37
all of these	37
with the same	37
is similar to	37
the content of	37
distribution of the	37
was identified as	37
is used for	36
been implicated in	36
we found a	36
not show any	36
of the resulting	36
the change in	36
replacement of the	36
the nervous system	36
significant reduction in	36
traditional chinese medicine	36
with the aim	36
from the seeds	36
can be obtained	36
for the preparation	36
have been investigated	36
it was demonstrated	36
these results are	36
belong to the	36
the goal of	36
compared to other	36
has led to	36
of the p	36
by measuring the	36
significant decrease in	36
in living cells	36
be applied to	36
compounds have been	36
umbilical vein endothelial	36
in aqueous solution	36
to form the	36
the degradation of	36
resistant staphylococcus aureus	36
was performed on	36
at mg kg	36
is likely to	36
the occurrence of	36
activity compared to	36
kim et al	36
been found in	36
used as the	36
the metabolism of	36
the decrease of	36
to control the	36
in the primary	36
cells in vitro	36
the leaves of	36
will be used	36
the problem of	36
at the time	36
of the corresponding	36
used to study	36
act as a	36
modulation of the	36
it is necessary	36
and amino acid	36
is a common	36
identified as a	36
inhibitor of the	36
determined by the	36
were evaluated by	36
mrna and protein	36
are required for	36
this is a	36
carried out using	36
is believed to	36
can be found	36
in the design	35
is a highly	35
significant difference between	35
is to investigate	35
has been observed	35
as an alternative	35
were included in	35
examined the effects	35
as shown by	35
inhibitory effects on	35
of oxidative stress	35
the last decade	35
in the heart	35
neural stem cells	35
in this process	35
structure of a	35
agreement with the	35
from the same	35
leading to a	35
specificity of the	35
to measure the	35
the molecular mechanism	35
extract of the	35
according to their	35
produced by the	35
radical scavenging activity	35
for the identification	35
response to the	35
the selection of	35
fold increase in	35
evaluated for their	35
to the high	35
be noted that	35
human breast cancer	35
compounds in the	35
in complex with	35
may not be	35
of the receptor	35
the substitution of	35
been suggested that	35
and mg ml	35
studies revealed that	35
study on the	35
was to evaluate	35
by western blot	35
the side chain	35
one of these	35
the replacement of	35
molecular docking studies	35
was to determine	35
in the expression	35
by addition of	35
study showed that	35
and treatment of	35
in the group	35
our results showed	35
the construction of	35
binding site of	35
the results indicate	35
involvement of the	35
has been studied	35
with the control	35
which in turn	35
form of the	35
aim was to	34
production of the	34
presence or absence	34
we describe the	34
profile of the	34
the sensitivity of	34
yang et al	34
essential oils and	34
the severity of	34
the efficiency of	34
and antimicrobial activities	34
significant difference in	34
widely used in	34
in this presentation	34
was performed to	34
play important roles	34
or absence of	34
was obtained by	34
the most abundant	34
studies were performed	34
cleavage of the	34
its role in	34
treatment of the	34
in a similar	34
activity in a	34
the administration of	34
information about the	34
and antiviral activities	34
of the binding	34
in a mouse	34
by increasing the	34
demonstrate that the	34
resulting in a	34
a subset of	34
the correlation between	34
any of the	34
of which are	34
a potent inhibitor	34
is a member	34
there are no	34
was significantly higher	34
of science and	34
in the ca	34
we have demonstrated	34
in a concentration	34
receptors in the	34
derivatives synthesis and	34
essential oil of	34
induction of apoptosis	34
amino acids were	34
in another study	34
not yet been	34
a mouse model	34
was based on	34
and oxidative stress	34
liu et al	34
a change in	34
we compared the	34
model of the	34
antiviral activities of	34
is considered to	34
be found in	34
a lot of	34
from the brown	34
play a key	34
are widely used	33
the phenyl ring	33
features of the	33
it could be	33
depend on the	33
the method of	33
in a number	33
the binding site	33
different concentrations of	33
development of novel	33
in cancer cells	33
the cleavage of	33
the progression of	33
our study was	33
the enzyme was	33
to be associated	33
was reported to	33
the separation of	33
compounds isolated from	33
as amine reagent	33
department of pharmacology	33
was determined in	33
encapsulated in sodium	33
comparison with the	33
the specificity of	33
and antifungal activities	33
has recently been	33
the prevention of	33
the design and	33
solid phase synthesis	33
against herpes simplex	33
the site of	33
to the standard	33
was followed by	33
is found in	33
probably due to	33
findings indicate that	33
caused by a	33
could be detected	33
carried out to	33
in view of	33
are needed to	33
concluded that the	33
an example of	33
to an increase	33
proteins in the	33
activity against gram	33
we hypothesize that	33
induced diabetic rats	33
similar results were	33
identifi cation of	33
our understanding of	33
the understanding of	33
is a very	33
as a potent	33
referred to as	33
were obtained in	33
of bioactive compounds	33
for production of	33
by the addition	33
quality of life	33
was also observed	33
antimicrobial potential of	33
rest of the	33
be important for	33
been reported in	33
both in vitro	33
can be easily	33
we also found	33
to be responsible	33
been identified as	33
secondary structure of	33
well known that	32
significantly increased in	32
in the s	32
according to our	32
participate in the	32
order to determine	32
is an essential	32
prior to the	32
basis for the	32
amino acids are	32
is very important	32
we have designed	32
can be detected	32
was observed that	32
no significant differences	32
the expression level	32
of some new	32
secondary aliphatic amines	32
fact that the	32
of the other	32
are the main	32
of the drug	32
we are now	32
its effect on	32
the series of	32
of the primary	32
were characterized by	32
design of new	32
not affected by	32
apoptotic cell death	32
order to obtain	32
was comparable to	32
the amplitude of	32
on the expression	32
may be due	32
assessment of the	32
with and without	32
of inhibition of	32
as a source	32
cells were treated	32
a component of	32
from the rhizomes	32
it may be	32
respiratory syncytial virus	32
followed by the	32
we have synthesized	32
resonance energy transfer	32
tumor cell lines	32
previous studies have	32
plays a role	32
the viability of	32
have been proposed	32
of the anti	32
the pattern of	32
but did not	32
substitution of the	32
resistant strains of	32
a role of	32
of escherichia coli	32
natural and synthetic	32
mechanism by which	32
in the cells	32
on the structure	32
the dynamics of	32
bind to the	32
as a function	32
as it is	32
were evaluated for	32
used in this	32
was studied by	32
the results suggested	32
on the same	32
extract of p	31
been demonstrated that	31
be explained by	31
gaba a receptors	31
vascular smooth muscle	31
have been widely	31
protective effects of	31
the presence or	31
potent than reference	31
in the mannich	31
of medicinal plants	31
range of biological	31
serum levels of	31
the presence and	31
primary and secondary	31
molecular mass of	31
human cancer cell	31
may be used	31
concentration in the	31
and have been	31
is also a	31
and at the	31
target for the	31
are presented in	31
b and c	31
the pathophysiology of	31
significantly higher than	31
not only the	31
were tested against	31
expression of a	31
of the b	31
high level of	31
lead to a	31
we believe that	31
have studied the	31
also able to	31
is required to	31
ranging from to	31
balb c mice	31
at least two	31
in a study	31
was not affected	31
gene expression of	31
chemical synthesis of	31
isolation and characterization	31
seeds of psoralea	31
are capable of	31
terminus of the	31
may be an	31
the amino acids	31
mannich bases and	31
of antiviral activity	31
was determined using	31
many of these	31
investigate the role	31
in this regard	31
of the structure	31
faculty of medicine	31
a library of	31
of the reaction	31
results demonstrated that	31
is not a	31
on the th	31
discussion and conclusion	31
world health organization	31
comparison to the	31
to the n	31
synthesis of new	31
for in vivo	31
study was designed	31
and could be	31
expressed in a	31
are important for	31
oil encapsulated in	31
cell cycle arrest	31
evaluation of their	31
native chemical ligation	31
we observed a	31
a loss of	31
to be highly	31
useful in the	31
samples were taken	31
they can be	31
widely distributed in	31
by inhibiting the	30
the measurement of	30
should be noted	30
growth inhibition of	30
are considered as	30
cell growth and	30
to the target	30
in a recent	30
by flow cytometry	30
has been a	30
a and a	30
was obtained from	30
the host cell	30
measured by the	30
on the contrary	30
a systematic review	30
of biologically active	30
mouse model of	30
which is an	30
faculty of science	30
decreased in the	30
pomegranate juice consumption	30
shows that the	30
antioxidant activities of	30
results were obtained	30
in hepg cells	30
and related compounds	30
activated protein kinase	30
presence of an	30
and biological activities	30
protein in the	30
was analyzed by	30
the characteristics of	30
with the addition	30
proteins have been	30
with the highest	30
taking into account	30
identified in the	30
but also the	30
the secretion of	30
induced oxidative stress	30
mannich bases were	30
vein endothelial cells	30
was evaluated in	30
to the production	30
growth of the	30
these compounds are	30
was achieved by	30
and increased the	30
was demonstrated that	30
the family of	30
of silver nanoparticles	30
of the product	30
were performed to	30
wild type and	30
nuclear magnetic resonance	30
it is worth	30
interacts with the	30
minimum inhibitory concentration	30
amino group of	30
can be considered	30
antitumor activity of	30
elevated levels of	30
among the most	30
conflict of interest	30
value of the	30
size exclusion chromatography	30
gene expression and	30
recent advances in	30
of cancer cells	30
active than the	30
influenced by the	30
that these compounds	30
to establish the	30
of naturally occurring	30
also found that	30
mechanisms of the	30
known as the	30
in the protein	30
of the world	29
involved in this	29
chemical composition of	29
of the effect	29
of these enzymes	29
has been described	29
increased expression of	29
synthesized and evaluated	29
in the hippocampal	29
higher than in	29
quality of the	29
previously reported that	29
in our previous	29
data show that	29
review of the	29
the magnitude of	29
and antiviral activity	29
samples were collected	29
only a few	29
approved by the	29
of the four	29
were added to	29
this suggests that	29
to explain the	29
may be related	29
changes of the	29
significant increase of	29
the significance of	29
to be important	29
the assembly of	29
of cells with	29
the ic values	29
be effective in	29
of coumarin derivatives	29
japan we have	29
ic values in	29
search for new	29
optimization of the	29
was accompanied by	29
various types of	29
zhang et al	29
a model for	29
the maintenance of	29
to act as	29
by western blotting	29
is critical for	29
for their ability	29
on the presence	29
are used to	29
we will discuss	29
of the parent	29
free radical scavenging	29
the phosphorylation of	29
even in the	29
binds to the	29
can be achieved	29
class of compounds	29
and there is	29
for the control	29
were collected from	29
of nitric oxide	29
is a well	29
time course of	29
in the membrane	29
min mg protein	29
and antioxidant activities	29
and activity of	29
involved in a	29
increased levels of	29
in the united	29
essential oils of	29
shown in table	29
is reported to	29
resulted in an	29
the potency of	29
department of anatomy	29
activated protein c	29
the gene expression	29
and absence of	29
by binding to	29
of the s	29
can be a	29
light on the	29
a role for	29
supported by a	29
the emergence of	29
a high degree	29
the catalytic activity	29
hydrolysis of the	29
inactivation of the	29
after h of	29
cells and the	29
of peptides and	29
have focused on	29
by inhibition of	29
of lipid peroxidation	29
in the aminomethyl	29
we will present	29
of the effects	29
is possible that	28
are likely to	28
in line with	28
disruption of the	28
limited number of	28
all of them	28
of human rhinovirus	28
the comparison of	28
cytotoxic effects of	28
in the food	28
a small number	28
for the formation	28
this effect was	28
bacteria and fungi	28
to prevent the	28
the conformation of	28
in the body	28
mesenchymal stem cells	28
were evaluated in	28
those in the	28
by solid phase	28
may have a	28
and expression of	28
the standard drug	28
at low concentrations	28
in rats with	28
a recent study	28
an overview of	28
molecular biology and	28
is not clear	28
was also found	28
and prevention of	28
is essential to	28
and with the	28
in all the	28
shown in fig	28
well as to	28
this indicates that	28
a signi fi	28
in the c	28
for detection of	28
is still a	28
that could be	28
that the activity	28
to better understand	28
crucial for the	28
mitochondrial membrane potential	28
was increased in	28
remains to be	28
compared with those	28
an essential role	28
investigate the effect	28
the results are	28
to create a	28
we find that	28
play a crucial	28
the authors declare	28
both in the	28
in this respect	28
the peptides were	28
of pharmaceutical sciences	28
use of a	28
is a promising	28
in clinical trials	28
we report on	28
been carried out	28
has been investigated	28
mutation in the	28
molecular basis of	28
means of the	28
a broad range	28
been identified in	28
we determined the	28
is a powerful	28
to the discovery	28
were associated with	28
studies suggest that	28
compounds such as	28
to modulate the	28
of the genes	28
of the immune	28
shown to inhibit	28
for more than	28
of the antiviral	28
more effective than	28
was evaluated using	28
of the substrate	28
is the main	28
activity has been	28
conformation of the	28
experiments were carried	28
the decrease in	28
might be a	28
the cell wall	28
male and female	28
lactic acid bacteria	28
with the exception	28
of mg ml	28
in this paper	28
mrna expression of	28
of prostate cancer	28
essential role in	28
for inhibition of	28
the exception of	28
of up to	28
order to study	28
did not change	28
was determined as	28
risk factors for	28
of a number	28
focus on the	28
and it has	28
and antibacterial activity	28
the state of	28
decrease of the	28
of the antibiotic	28
their antimicrobial activity	28
against oxidative stress	28
examined the effect	28
of plant extracts	28
for min at	28
cytotoxic activity of	28
be an important	28
the results revealed	28
japan in the	27
in vivo in	27
in vitro study	27
of the control	27
are related to	27
of the plasma	27
be one of	27
well as their	27
in the search	27
portion of the	27
the beginning of	27
exposed to the	27
the assessment of	27
in the left	27
are one of	27
previously shown that	27
of this protein	27
study was conducted	27
is expected to	27
in the activity	27
compared to controls	27
the creation of	27
have reported that	27
during the last	27
the stimulation of	27
huang et al	27
for the prevention	27
a better understanding	27
influenza a virus	27
terminal part of	27
of the host	27
riken brain science	27
as a therapeutic	27
relative to the	27
of a peptide	27
comparable to the	27
highly expressed in	27
with a view	27
activity on the	27
the origin of	27
in vitro assays	27
stages of the	27
in human plasma	27
been observed in	27
extracted from the	27
has been associated	27
programmed cell death	27
the target protein	27
compared with control	27
we hypothesized that	27
were screened for	27
of the process	27
concentration of mg	27
was tested in	27
developed for the	27
of a variety	27
were identified as	27
regardless of the	27
a and c	27
morbidity and mortality	27
inhibited the growth	27
and the most	27
in in vitro	27
tool for the	27
the rats were	27
to the c	27
catalytic activity of	27
against staphylococcus aureus	27
department of biochemistry	27
synthesis and antimicrobial	27
the antimicrobial potential	27
interfere with the	27
functions as a	27
male wistar rats	27
over the past	27
two of the	27
the immune response	27
compounds were evaluated	27
have been obtained	27
the roles of	27
addition of the	27
of particular interest	27
had to be	27
th day and	27
absence of the	27
and to the	27
to develop new	27
a view to	27
to this end	27
antimicrobial activity and	27
in a wide	27
are active against	27
cells treated with	27
was no significant	27
the enzyme is	27
bound to the	27
background and aims	27
the diagnosis of	27
our aim was	27
the molecular basis	27
use in the	27
colon cancer cells	27
closely related to	27
studies demonstrated that	27
work is to	27
pi k akt	27
to the activity	27
observed for the	27
methanol extract of	27
an ic of	27
this may be	27
cd and cd	27
antiviral effects of	27
with or without	27
potent activity against	26
evidence that the	26
these peptides are	26
little or no	26
was characterized by	26
and the resulting	26
a pivotal role	26
in the post	26
are required to	26
is widely used	26
is represented by	26
there are many	26
these results demonstrate	26
of membrane proteins	26
able to bind	26
investigate the effects	26
the utilization of	26
to a lesser	26
cell lines and	26
the order of	26
activity of flavonoids	26
the development and	26
in vitro in	26
as a major	26
chen et al	26
was performed with	26
to be in	26
their effects on	26
the activity and	26
experiments were performed	26
results will be	26
in all cases	26
amino acid composition	26
trypsin inhibitory activity	26
a powerful tool	26
the patients with	26
synthesized by the	26
has become a	26
observed that the	26
of the cellular	26
and analysis of	26
proteins that are	26
tuberculosis h rv	26
after oral administration	26
to play an	26
it is the	26
should be considered	26
to the synthesis	26
have previously shown	26
the concentrations of	26
also found to	26
the reaction mixture	26
inflammatory activity of	26
we report here	26
in the structure	26
well as for	26
antimicrobial properties of	26
performance of the	26
the highest value	26
of the d	26
activation in the	26
could be useful	26
cell lines were	26
to the identification	26
series of mannich	26
were performed using	26
proteins of the	26
by the russian	26
as a marker	26
the evolution of	26
order to identify	26
have been observed	26
in the cns	26
for h at	26
was treated with	26
evidence suggests that	26
be present in	26
to find out	26
in a cell	26
were measured in	26
believed to be	26
be a useful	26
in medicinal chemistry	26
that most of	26
high affi nity	26
could also be	26
to the same	26
of the e	26
we decided to	26
chemical modification of	26
the control and	26
the work was	26
to investigate whether	26
activity in vivo	26
in the host	26
in both the	26
the oxidative stress	26
that they are	26
mg kg b	26
processes such as	26
quantitative analysis of	26
a long time	26
to address the	26
effect of a	26
antioxidant activity was	26
fold higher than	26
and the effect	26
was increased by	26
isothermal titration calorimetry	26
the cerebral cortex	26
was more potent	26
gaba a receptor	26
action of these	26
of some of	26
were studied in	26
of the known	26
as an important	26
the complexity of	26
the reference drug	26
after treatment with	26
of the catalytic	26
been proposed to	26
dynamics of the	26
was monitored by	26
in the cytoplasm	26
our data suggest	26
of influenza virus	26
be concluded that	26
their role in	26
acids in the	26
selective inhibitors of	26
of neurons in	26
to the corresponding	26
modes of action	25
are necessary to	25
has been implicated	25
for a long	25
also been reported	25
the treatment with	25
double mannich bases	25
of this plant	25
of the novel	25
is the only	25
of the recombinant	25
open reading frame	25
the difference in	25
in vitro evaluation	25
has shown that	25
and does not	25
results from the	25
and the presence	25
decline on day	25
after days of	25
a highly conserved	25
activity of this	25
are consistent with	25
by in vitro	25
and has a	25
a significant reduction	25
to be present	25
a comparison of	25
impact of the	25
the affinity of	25
vitro activity of	25
binding properties of	25
the human body	25
mainly due to	25
a new method	25
in the aromatic	25
the appearance of	25
addition of volatile	25
blood pressure and	25
the small intestine	25
is induced by	25
in this research	25
these data indicate	25
the overexpression of	25
their biological activity	25
content in the	25
involved in cell	25
of the initial	25
to each other	25
showed a significant	25
methods for the	25
the prevalence of	25
release of the	25
goal of this	25
were reported to	25
formation in the	25
starting point for	25
different stages of	25
in the cerebellum	25
endothelial growth factor	25
amino acids with	25
the establishment of	25
upper respiratory tract	25
each of these	25
be carried out	25
identification of a	25
has been known	25
biologically active peptides	25
function in the	25
study revealed that	25
are necessary for	25
concentrations in the	25
the migration of	25
activities of some	25
the cause of	25
in hek cells	25
may serve as	25
in a rat	25
resulting from the	25
were grown in	25
during the course	25
peptides and their	25
is also known	25
are reported to	25
the transcription factor	25
properties of these	25
cordyceps sinensis on	25
impact on the	25
the potential for	25
it would be	25
biological activity and	25
order to improve	25
introduction of the	25
be expressed in	25
and protein expression	25
is difficult to	25
we tested the	25
that there are	25
proteins such as	25
this study the	25
there have been	25
the effect on	25
the improvement of	25
affinity for the	25
peptides were synthesized	25
has the potential	25
as the main	25
which are the	25
terminal domain of	25
the transport of	25
derived from a	25
was subjected to	25
comparable to those	25
the initiation of	25
against candida albicans	25