This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-002823-n55xvwkf | Alveolar macrophages prevent lethal influenza pneumonia by inhibiting infection of Type-1 alveolar epithelial cells Lethal influenza infection: is a macrophage to blame? |
| cord-006473-ey35h7ry | Disease or diagnosis? |
| cord-102725-k0xhbssu | A Neuro- Lympho- Vascular Component of Multiple Sclerosis and Alzheimer's Disease? |
| cord-006172-ndmf5ekp | What have neurologists learned about complications of 2009 H1N1 virus infections worldwide? |
| cord-005479-wj2xmp8h | Two- weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of young patients with good prognosis( normal LDH) aggressive lymphomas: results of the NHL- B1 trial of the DSHNHL Two- weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of elderly patients with aggressive lymphomas: results of the NHL- B2 trial of the DSHNHL Granulocyte colonystimulating factor or neutrophil- induced pulmonary toxicity: myth or reality? |
| cord-023369-xwclh6ih | Serological evidence for congenital transmission of human herpesvirus 6 Examination of human breast milk for evidence of human herpesvirus 6 by polymerase chain reaction Human herpesvirus 6 and neuroinflammation Human herpesvirus-6 entry into the central nervous system through the olfactory pathway Association of human herpesvirus 6 infection of the central nervous system with recurrence of febrile convulsions Human herpesvirus 6 DNA in cerebrospinal fluid specimens from allogeneic bone marrow transplant patients: does it have clinical significance? |
| cord-005014-qp4rrwr4 | Progressive Borrelien- Enzephalomyelitis Lyme disease, a tick- borne spirochetosis? |
| cord-263530-t9ryky6f | incidence of meningoencephalitis in the absence of CSF pleocytosis Central nervous system infections in the absence of cerebrospinal fluid pleocytosis Cerebrospinal fluid white cell count: discriminatory or otherwise for enteroviral meningitis in infants and young children? |
| cord-349329-f0pbd968 | a postinfluenza pneumococcal pneumonia model Lung epithelial GM- CSF improves host defense function and epithelial repair in influenza virus pneumonia- a new therapeutic strategy? |
| cord-320940-e7ic2pnc | Spain A review of the studies of the cardiovascular health effects of methylmercury with consideration of their suitability for risk assessment Low dose mercury toxicity and human health Mercury and autism: accelerating evidence? |
| cord-021772-5v4gor2v | Clinical and clinicopathological features of non- suppurative meningoencephalitis in young greyhounds in Ireland Cerebrospinal fluid eosinophilia in dogs What is your diagnosis? |
| cord-021772-5v4gor2v | What is your diagnosis? |
| cord-345210-6f8niif5 | The Online Journal of Issues in Nursing Factors associated with preparedness of the US healthcare system to respond to a pediatric surge during an infectious disease pandemic: is our nation prepared? |
| cord-006869-g2q1gpp0 | QI method be used to incrementally add and evaluate individual facets of neuroprotective therapeutic bundles? |
| cord-025251-evnfvc0l | Inhaled therapeutics for prevention and treatment of pneumonia Rapid- response vaccines- does DNA offer a solution? |
| cord-025251-evnfvc0l | influenza virus infection Lung epithelial GM- CSF improves host defense function and epithelial repair in influenza virus pneumonia- a new therapeutic strategy? |
| cord-021452-9rukc80y | an inappropriate standard of care Is the role of steroids in acute spinal cord injury now resolved? |
| cord-298894-t5hyfum3 | Guillain- Barré syndrome associated with SARS- CoV-2 Guillain- Barré syndrome associated with SARS- CoV-2 infection: causality or coincidence? |
| cord-006880-9dgmdtj8 | Patients were asked"do you enjoy life more, about the same, or less than you did before your brain hemorrhage?" |
| cord-285151-zynor0b2 | Are plasma biomarkers of immune activation predictive of HIV progression: a longitudinal comparison and analyses in HIV-1 and HIV-2 infections? |
| cord-307563-almkb3zd | Dependency on glasses/ contact lenses(''How many times a week do you wear your glasses/ contact lenses?''). |
| cord-023748-3kfy36hg | Do penicillins really increase the frequency of a rash when given during Epstein- Barr virus primary infection? |
| cord-023748-3kfy36hg | Does this child have bacterial meningitis? |
| cord-023748-3kfy36hg | The future possibilities of diagnostic testing for the evaluation of febrile infants Rectal versus axillary temperatures: is there a significant difference in infants less than 1 year of age? |
| cord-309476-hel3h25h | : recommandations pour un diagnostic étiologique Infectious encephalitis: Management without etiological diagnosis 48hours after onset Guidelines on the management of infectious encephalitis in adults Should a hospitalized child receive empiric treatment with acyclovir? |
| cord-309476-hel3h25h | In: WHOrecommended standards for surveillance of selected vaccinepreventable diseases WHO/ V&B Metagenomic sequencing complements routine diagnostics in identifying viral pathogens in lung transplant recipients with unknown etiology of respiratory infection Acute encephalitis in the immunocompromised individual Central nervous system infection diagnosis by next- generation sequencing: a glimpse into the future? |
| cord-289861-i6bfuvq1 | Sekhar title: CSF neopterin, a useful biomarker in children presenting with influenza associated encephalopathy? |
| cord-289861-i6bfuvq1 | what have we learnt from the ordeal? |
| cord-266034-811lov8f | A first case of meningitis/ encephalitis associated with SARS- coronavirus-2 Hematological findings and complications of COVID-19 Toxic and acquired metabolic encephalopathies: MRI appearance Immune regulation of antibody access to neuronal tissues Detection of SARS- CoV-2 in different types of clinical specimens How many patients with anti- JEV IgM in cerebrospinal fluid really have Japanese encephalitis? |
| cord-266034-811lov8f | Importance of cerebrospinal fluid investigation during dengue infection in Brazilian Amazonia region Detection of human parvovirus 4 DNA in the patients with acute encephalitis syndrome during seasonal outbreaks of the disease in Gorakhpur Long- term follow- up after treatment of rabies by induction of coma Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system? |
| cord-031907-ilhr3iu5 | Extracellular Vesicle- based liquid biopsy in Acute Myeloid Leukaemia: a reliable source of residual disease biomarkers? |
| cord-258787-n49zrfsp | Where, When, How, and Why? |
| cord-258787-n49zrfsp | in ovarian cancer in mice and humans Granulocyte- colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes Tumor- associated neutrophils: friend or foe? |
| cord-345267-u24g6607 | COVID-19) Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? |
| cord-345267-u24g6607 | Lung epithelial GM- CSF improves host defense function and epithelial repair in influenza virus pneumonia- a new therapeutic strategy? |
| cord-329527-0rlotyz3 | Taxonomy of the order Mononegavirales: update 2016 H1N1 encephalitis with malignant edema and review of neurologic complications from influenza Neurological complications of middle east respiratory syndrome coronavirus: a report of two cases and review of the literature Human metapneumovirus persists in BALB/ c mice despite the presence of neutralizing antibodies Taxonomy of the order Mononegavirales: update 2018 Bronchiolitis- associated encephalopathy in critically- ill infants: an underestimated complication? |
| cord-329527-0rlotyz3 | what have we learnt from the ordeal? |
| cord-328763-hcbs20a0 | Producing GM- CSF: a unique T helper subset? |
| cord-328763-hcbs20a0 | Why did IL-12/ IL-23 antibody therapy fail in multiple sclerosis? |
| cord-291553-j9nn5g70 | Deep sequencing for the detection of virus- like sequences in the brains of patients with multiple sclerosis: detection of GBV- C in human brain GB virus C: the good boy virus? |
| cord-291553-j9nn5g70 | The GB viruses: a review and proposed classification of GBV- A, GBV- C( HGV), and GBV- D in genus Pegivirus within the family Flaviviridae G- pers creepers, where'd you get those papers? |
| cord-291553-j9nn5g70 | chronic fatigue syndrome Lack of GB virus C/ hepatitis G virus sequences in cerebrospinal fluid in patients with central nervous system infections A case- control study of transmission routes for GB virus C/ hepatitis G virus in Swedish blood donors lacking markers for hepatitis C virus infection GB virus C/ hepatitis G virus infection in patients investigated for chronic liver disease and in the general population in southern Sweden Prevalence of GB virus C( also called hepatitis G virus) markers in Norwegian blood donors Seroprevalence of GB virus C and persistence of RNA and antibody A novel T cell evasion mechanism in persistent RNA virus infection Humoral immune response to the E2 protein of hepatitis G virus is associated with long- term recovery from infection and reveals a high frequency of hepatitis G virus exposure among healthy blood donors GB Virus C epidemiology in denmark: different routes of transmission in children and low- and high- risk adults Detection of antibodies to a putative hepatitis G virus envelope protein Antibody to GBV- C second envelope glycoprotein( anti- GBV- C E2): is it a marker for immunity? |
| cord-310299-isdsestc | A first case of meningitis/ encephalitis associated with SARS- Coronavirus-2 Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host- virus interaction, and proposed neurotropic mechanisms Central Nervous System Involvement by Severe Acute Respiratory Syndrome Coronavirus-2( SARS- CoV-2) Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? |
| cord-310299-isdsestc | cord-310299-isdsestc authors: Hosseini, Akram A.; Shetty, Ashit K.; Sprigg, Nikola; Auer, Dorothee P.; Constantinescu, Cris S. title: Delirium as a presenting feature in COVID-19: neuroinvasive infection or autoimmune encephalopathy? |
| cord-015389-vwgai4k9 | C allow a long- term hematopoietic reconstitution and clinical course even if storage is greater than 6 months? |
| cord-015389-vwgai4k9 | Can type of delivery infl uence cord blood units'quality? |
| cord-015389-vwgai4k9 | The disease free survival in this small cohort of high risk patients with t- FL is encouraging but needs longer follow- up Rituximab or not? |
| cord-018034-gx5c9mk8 | The fate of skin monografts transplanted to the brain, to subcutaneous tissue and to the anterior chamber of the eye Tissue- specific migration of lymphocytes: a key role for Th1 and Th2 cells? |
| cord-018034-gx5c9mk8 | brain edema or vascular engorgement? |
| cord-022594-fx044gcd | Does the history of multiple sclerosis go back as far as the 14th century? |
| cord-022594-fx044gcd | The 150-year anniversary of multiple sclerosis: Does its early history give an etiological clue? |
| cord-022594-fx044gcd | When should treatment be initiated in patients with very early demyelinating disease? |
| cord-302435-6nrfipz8 | A unique microglia type associated with restricting development of Alzheimer's disease Do glia drive synaptic and cognitive impairment in disease? |
| cord-302435-6nrfipz8 | The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2 CSF sTREM2: marking the tipping point between preclinical AD and dementia? |
| cord-302435-6nrfipz8 | the missing link in neuroprotection and neurodegeneration? |
| cord-283367-azzy2t1a | A first case of meningitis/ encephalitis associated with SARS- Coronavirus-2 Acute transverse myelitis after COVID-19 pneumonia COVID-19-associated meningoencephalitis complicated with intracranial hemorrhage: a case report COVID-19 and intracerebral haemorrhage: causative or coincidental? |
| cord-283367-azzy2t1a | COVID-19-related Guillain- Barré syndrome different? |
| cord-283367-azzy2t1a | CT and MRI features Encephalopathy in patients with COVID-19:"causality or coincidence? |
| cord-283367-azzy2t1a | The neuroinvasive potential of SARS- CoV2 may play a role in the respiratory failure of COVID-19 patients Tocilizumab- associated multifocal cerebral thrombotic microangiopathy Tocilizumab and multiple sclerosis: a causal relationship? |
| cord-005460-ezrn8cva | Any role of high- dose chemotherapy in mediastinal nonseminoma germ cell tumors? |
| cord-005460-ezrn8cva | Gut microbiota and hematopoietic stem cell transplantation: where do we stand? |
| cord-005460-ezrn8cva | Is it feasible? |
| cord-005460-ezrn8cva | To wash or not to wash? |
| cord-333805-xmqs2ax7 | A Retrospective Multicenter Study Guillain- Barre syndrome associated with SARS- CoV-2 infection: causality or coincidence? |
| cord-333805-xmqs2ax7 | Does SARD- CoV-2 invade the brain? |
| cord-333805-xmqs2ax7 | The management of encephalitis: clinical practice guidelines by the Infectious Diseases Society of America Guillain- Barre syndrome following COVID-19: new infection, old complication? |
| cord-333805-xmqs2ax7 | causative or coincidental? |
| cord-284038-93s3ffoy | A Potential New Neuropsychiatric Condition Triggered by Novel Coronavirus Infection and the Inflammatory Response? |
| cord-284038-93s3ffoy | COVID-19-White matter and globus pallidum lesions: Demyelination or small- vessel vasculitis? |
| cord-284038-93s3ffoy | COVID-19: What do we need to know about ICU delirium during the SARS- CoV-2 pandemic? |
| cord-284038-93s3ffoy | The New England journal of medicine Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? |
| cord-284038-93s3ffoy | Underestimated Opportunistic Pathogens of the Central Nervous System? |
| cord-284038-93s3ffoy | medRxiv Epidemiological, clinical characteristics of cases of SARS- CoV-2 infection with abnormal imaging findings Guillain- Barré syndrome associated with SARS- CoV-2 infection: causality or coincidence? |
| cord-277889-8u685f45 | Could myo- inositol treatment downregulate inflammation and cytokine release syndrome in SARS- CoV-2? |
| cord-277889-8u685f45 | The IL-17 Family of Cytokines in Health and Disease Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus Distinct immune response in two MERS- CoV- infected patients: can we go from bench to bedside? |
| cord-277889-8u685f45 | odd one out or part of the family? |
| cord-277889-8u685f45 | r o o f amplified? |
| cord-014976-546zaoxn | Are peak level measurements of cyclosporin A useful in allogeneic stem cell transplantation? |
| cord-014976-546zaoxn | How much change in quantitative chimerism values is enough for clinical significance? |
| cord-014976-546zaoxn | The case raises a number of important questions regarding the biological implications of chimerism values, such as: 1) is 10% a relative or absolute figure; 2) is there a minimum/ threshold chimerism value for functionality of the graft in these metabolic diseases; 3) do all patients have the same% chimerism interval/ differential and threshold? |
| cord-014976-546zaoxn | Why will an amotosalen- based protocol for extracorporeal photopheresis be valuable? |
| cord-014976-546zaoxn | how to learn from artefacts? |
| cord-006444-eq56zhtd | 10 patients showed antitumor response to immunotherapy: 3 complete remissions( CR) and? |
| cord-006444-eq56zhtd | Are the growth factors simply permissive for these processes? |
| cord-006444-eq56zhtd | Or do they have an inductive role to play in lineage commitment of stem cells and subsequent maturation into phenotypically mature cells? |
| cord-006444-eq56zhtd | The number of activated T- cells defined by the antigens CD38, HLA- DR and CD56 were low or in the normal range, and did not fu~ er decrease during therapy in contrast to the non- activated T- cells.? |
| cord-006444-eq56zhtd | W41/88/ Ha-1- 2 from the Deutsche Krebshilfe and 90.055.1 from the Withe~ m- Sander Stiftung IS GRANULOCYTE COLONY- STIMULATING FACTOR AN ANGIOGENIC FACTOR IN HUMAN GLIOBLASTOMA? |
| cord-006444-eq56zhtd | the high- dose chemotherapy consisted of prednisolone 60rag/ n? p.o. |
| cord-006870-f5w6fw6q | : Are you aware that Medicare can reject critical care charges( 99291 and 99292) can be rejected unless you are listed as a CMS'critical care provider'or as a neurocritical care provider? |
| cord-006870-f5w6fw6q | A management QEEG ADR in Poor Grade SAH: Is it Really Useful? |
| cord-006870-f5w6fw6q | Lumbar puncture in the presence of mass effect? |
| cord-006870-f5w6fw6q | Neurocritical care taxonomy code 2084A2900X? |
| cord-006870-f5w6fw6q | Q3: Are you aware why the NCC taxonomy code was created? |
| cord-006870-f5w6fw6q | Q6: Are you aware of rejection of critical care charges happening at your own institution due to this misclassification? |
| cord-006870-f5w6fw6q | Question( Q1) and( Answers, A1): Are you a neurology or neurosurgery back grounded intensivist who does neurocritical care at your hospital? |
| cord-006870-f5w6fw6q | What is your primary department for revenue collection? |
| cord-005453-4057qib7 | Disclosure: Nothing to declare Can the drugs used before autologous hematopoietic stem cell transplantation have impact on CMV reactivation that results in decreased os in myeloma patients after ASCT? |
| cord-005453-4057qib7 | Disclosure: Nothing to declare In haploidentical transplants is the incidence of acute and chronic GVHD strictly related to the stem cell source? |
| cord-005453-4057qib7 | Disclosure: Nothing to declare P620 Does body mass index( BMI) pose a risk to outcome for pediatric non- infantile patients undergoing hematopoietic cell transplantation( HSCT)? |
| cord-005453-4057qib7 | Disclosure: Nothing to declare Pre- and- post magnetic resonance imaging of hips and knees for detecting osteonecrosis in children undergoing hematopoietic cell transplantation: In whom is it necessary? |
| cord-005453-4057qib7 | Disclosure: Nothing to disclose Is there any impact of the uric acid levels during the preand early post- graft infusion period, on the GVHD occurence and allotransplant outcome? |
| cord-005453-4057qib7 | Do we need to freeze hematopoietic cells for autotransplants in patients with myeloma conditioned with melphalan? |
| cord-005453-4057qib7 | Is fungal prophylaxis necessary in non myeloablative peripheral blood stem cell allogeneic transplantation in the pre- engrafment period? |
| cord-005453-4057qib7 | Is it really GVHD? |
| cord-005453-4057qib7 | Nothing to declare Is mobilization with chemotherapy effect response in the multiple myeloma? |
| cord-005453-4057qib7 | Nothing to declare Is there any association between thrombotic risk factors and veno- oclusive disease in childhood allogeneic hematopoietic stem cell transplantation? |
| cord-022527-a0x6lws3 | : could immunosuppression of the eosinophilic myositis alter the early natural course of the dystrophic disease? |
| cord-022527-a0x6lws3 | Allergic pulmonary inflammation in mice is dependent on eosinophil- induced recruitment of effector T cells Human eosinophils constitutively express multiple Th1, Th2, and immunoregulatory cytokines that are secreted rapidly and differentially Eosinophils: singularly destructive effector cells or purveyors of immunoregulation? |
| cord-022527-a0x6lws3 | Calpain 3: a key regulator of the sarcomere? |
| cord-022527-a0x6lws3 | How Did the Eosinophil's Biology Further Link This Cell Type to Asthma? |
| cord-022527-a0x6lws3 | How does the critical role of redox 49 inform eosinophil function in relation to DAMPs? |
| cord-022527-a0x6lws3 | How might eosinophils contribute to stent- related thrombosis? |
| cord-022527-a0x6lws3 | However, the question remains: are eosinophilic contents biomarkers of restenosis and thrombosis or do they actively contribute to these processes? |
| cord-022527-a0x6lws3 | Should we be cautious? |
| cord-022527-a0x6lws3 | Specifically, do eosinophil activities limit tumor growth through destructive effector functions or do eosinophilderived immunoregulation and tissue repair/ remodeling promote tumor growth and metastasis? |
| cord-022527-a0x6lws3 | The eosinophil- mediated antitumor activity of interleukin-4 Human Eosinophils Exert TNF-{alpha} and Granzyme A- Mediated Tumoricidal Activity toward Colon Carcinoma Cells Selective depletion of eosinophils or neutrophils in mice impacts the efficiency of apoptotic cell clearance in the thymus Eosinophils in health and disease: the LIAR hypothesis NK cells: innate immunity against hematological malignancies? |
| cord-022527-a0x6lws3 | What factor(s) could preelevate ECP levels in individuals who had not yet been exposed to potential allergens contained in DES? |
| cord-022527-a0x6lws3 | What factors related to coronary stents and/or their deployment attract eosinophils to stented vessel segments? |
| cord-022527-a0x6lws3 | eosinophil infiltration of solid tumors is an early and persistent inflammatory host response Eosinophil degranulation: an evolutionary vestige or a universally destructive effector function? |
| cord-009713-sxd4t2tz | And with improvements leads to new interventions, can new assessment lead to new interventions? |
| cord-009713-sxd4t2tz | Can assessments lead to interventions? |
| cord-009713-sxd4t2tz | Can this system be measured for its effectiveness and improved based on feedbacks and results? |
| cord-009713-sxd4t2tz | How reliable is measuring CSF opening pressure under GA? |
| cord-009713-sxd4t2tz | Important questions raised were: Should all obese children with pIIH have access to a specialised obesity service? |
| cord-009713-sxd4t2tz | No. 061 NMDA receptor encephalitis a potential complication of biologic therapy for juvenile idiopathic arthritis? |
| cord-009713-sxd4t2tz | Should CSF diversion surgery be restricted to cases of sight threatening pIIH only? |
| cord-009713-sxd4t2tz | Should all children have dedicated venographic imaging? |
| cord-009713-sxd4t2tz | Should repeat LPs be done for persistent symptoms? |
| cord-009713-sxd4t2tz | What are the information needs of parents whose child is diagnosed with glutaric aciduria type 1 to help preserve neuro- developmental outcome? |
| cord-009713-sxd4t2tz | What are the perspectives and understanding of healthcare professionals including occupational therapists on treatment and care of babies with infantile spasms and early- onset epilepsy? |
| cord-009713-sxd4t2tz | Where LP is not possible should ICP monitoring always be done? |
| cord-022659-chwk2bs4 | ( mean 2 standard error of mean) without U74500A and was reduced to 0.76? |
| cord-022659-chwk2bs4 | 36* 12 yr), and 17 normal controls( 8 male, 9 female; 3 1? 9 yr) on specific neuropsychological( NP) and computer- administered tasks of attentional ability. |
| cord-022659-chwk2bs4 | Differentiated from Alzheimer's Disease? |
| cord-022659-chwk2bs4 | Do these results suggest that whatever causes MS can be eradicated in half of the demyelinating areas by the time of death? |
| cord-022659-chwk2bs4 | Does deprenyl have a symptomatic effect on patients with untreated and L- dopa- treated Parkinson's disease( PD)? |
| cord-022659-chwk2bs4 | Helpers( T4) decreased from 1,436 in controls to 985 in migraine patients, and total?' |
| cord-022659-chwk2bs4 | K, of tumor- free brain was 1.40 to 2.69( mean 1.89? 0.50). |
| cord-022659-chwk2bs4 | Normals completed the battery in 297 i 56, and cognitively declined patients completed the battery in 359? |
| cord-022659-chwk2bs4 | Once deprenyl is started, how long is it before another medication is needed to control symptoms of continued disease progression? |
| cord-022659-chwk2bs4 | PMN- mediated myelin oxidation was 1.89_ t 0.44 without drug and 0.64? 0.10 with drug( p< 0.02). |
| cord-022659-chwk2bs4 | Polyneuropathy: A Chronic Inflammatory Demyelinating Polyradiculoneuropathy Variant? |
| cord-022659-chwk2bs4 | Six months later, 7/24( 29.2%) patients still had low thresholds but the mean MEP/ CMAP ratio had dropped to 24.9? |
| cord-022659-chwk2bs4 | To investigate the effects of lacunar infarction( LI) on cognitive function, we examined 57 LI patients 3 months after stroke( age= 71.6? |
| cord-022659-chwk2bs4 | Twenty were considered to be at increased risk(? 85%), 14 at decreased risk(< 15%), and in 1 individual no modification could be given. |
| cord-022659-chwk2bs4 | We report a married couple, both of Clue to Etiology? |
| cord-022659-chwk2bs4 | We therefore compared 17 TS patients( 9 male, 8 female; mean age 32? 11 yr), 17 ADHD patients( 8 male, 9 female; |
| cord-022659-chwk2bs4 | mean* SD, 0.94? 0.33 and 0.74 |
| cord-022659-chwk2bs4 | well 2 0.6 x lo5 cells; ceramide- treated cells grew to 1.6 X lo5? |
| cord-015021-pol2qm74 | ( 3) Should future clinical trials be based on new classifications of illness such as MODS, SIRS, APACHE III, SAP II, MRM, etc., or should trials be dedicated to specific diseases-urinary tract infections, pneumonia, trauma patients, cardiac surgery and other specific problems, rather than generalized problems of sepsis, the sepsis syndrome and other classifications? |
| cord-015021-pol2qm74 | 3-Is the ACCP classification of sepsis useful at the bedside to select oatients? |
| cord-015021-pol2qm74 | Abnormally high skeletal muscle pO 2 in septic patients and its normalization during recovery: Evidence against tissue hypoxia but for impaired oxygen metabolism of skeletal muscle? |
| cord-015021-pol2qm74 | Administration of exogenous IFN? |
| cord-015021-pol2qm74 | And, finally, how can the participants be sure that the trial will be stopped at the right time, to ensure that no treatment is given to any patient that might be harmful? |
| cord-015021-pol2qm74 | Are all eligible patients being studied, and their results reported? |
| cord-015021-pol2qm74 | Are all the participants truly unbiased about the relative merits of the regimens being studied? |
| cord-015021-pol2qm74 | Before using the model for risk of death in septic patients, is it mandatory to validate it( by calibration, i.e. goodness of fit, and discrin'dnation, i.e., ROC curves) first on a data base using the same definition for sepsis as in the trial and secondly on the placebo group of the trial? |
| cord-015021-pol2qm74 | Can it achives a significant improvement in the septic course, organ dysfunction, and final outcome? |
| cord-015021-pol2qm74 | Conversely, administration of anti- IFN? |
| cord-015021-pol2qm74 | Correlatively the RNI inhibitor MMLA induces in vitro a decrease in the rate of bacterial killing, fxom 78% to 57%, in macrophages triggered with IFN-?+ LPS. |
| cord-015021-pol2qm74 | How can organ dysfunction and/or failure be defined? |
| cord-015021-pol2qm74 | How should we decide which of them should be brought to clinical trial? |
| cord-015021-pol2qm74 | If there is agreement that thin is an appropriate antibiotic protocol, should it not be used in all seriously ill septic patients in the hospital? |
| cord-015021-pol2qm74 | In contrast, GF109203X significantly reduced ICAM-1 expression induced by Interferon- y( IFN-?) |
| cord-015021-pol2qm74 | In fact, the IFN-? and IL-1 induced adhesion of PBMC to cytokine treated HUVEC could be downregulated by the PKC- inhibitor, whereas TNFc~-and LPS- mediated adhesion was not influenced. |
| cord-015021-pol2qm74 | In other words, should we now begin to have clinical trials on specific diseases with causes that are known and can be attacked? |
| cord-015021-pol2qm74 | Interferon-? |
| cord-015021-pol2qm74 | Is like being compared with like-are all the end points and the standards for measuring them clearly defined so that they can not be misunderstood? |
| cord-015021-pol2qm74 | Is there any role for antioxidative therapy in sepsis? |
| cord-015021-pol2qm74 | Is truly informed consent being sought that will satisfy not only the patient's right to choose what happens to him, but also the law of the land? |
| cord-015021-pol2qm74 | MIF secretion also was induced by TNFoc( 1 ng/ ml) and IFN? |
| cord-015021-pol2qm74 | MIF secretion is induced by LPS, TNFc~ and IFN?. |
| cord-015021-pol2qm74 | Macrophages of C57BL/10ScCr mice are incapable of producing interferon-~( IFN~) which we could show to be obligatory for the production of IFN? |
| cord-015021-pol2qm74 | On closer investigation the impaired IFN? |
| cord-015021-pol2qm74 | The IFN? |
| cord-015021-pol2qm74 | The absence of sensitization to LPS in Lps d C57BL/10ScCr mice was identified as being due to their inability to produce interferon-7( IFN?). |
| cord-015021-pol2qm74 | The clinical"take"rate o? cultured epithelial autografts( CEA) has been observed to Increase with transplantation to allodermls, but the reasons for the improved clinical performance have not yet been defined. |
| cord-015021-pol2qm74 | The inability to produce adequate amounts of IL-2, most likely attributable to alterations in the transmission of signals from the cell membrane to the nucleus, results in incomplete proliferative T- cell responses to antigenic stimuli, while a lack of? |
| cord-015021-pol2qm74 | There are reports of nentrophil dysfunction in inflammatory disorders of the skin( 2), Are there dysfunctions concerning the unspecific host defense in SIRS, as well? |
| cord-015021-pol2qm74 | This has not happened, however, and the question is"Why not"? |
| cord-015021-pol2qm74 | This might be due to a preexisting( genetic?) or more likely to an epiphenomenal receptor defect. |
| cord-015021-pol2qm74 | We have investigated the proinflaznmatory oytokine secretion patter~ by PMN in patients following major~hermal or tra~ matic injury and in volunteers fellowinq endotoxemia.? |
| cord-015021-pol2qm74 | What are the definitions? |
| cord-015021-pol2qm74 | What are the issues, then, in 1994, to be dealt with at this symposium and congress? |
| cord-015021-pol2qm74 | What are the mechanisms? |
| cord-015021-pol2qm74 | What is the aplpiieability of study results in typical clinical situations? |
| cord-015021-pol2qm74 | What is the availability of speciftc antibiotics at a participating hospital? |
| cord-015021-pol2qm74 | Will the patient's physicians agree to the protocol choice? |
| cord-015021-pol2qm74 | Will they be helpful in the study and esro of patients? |
| cord-015021-pol2qm74 | Will this contribute to better clinical trials, information basis and better research? |
| cord-015021-pol2qm74 | Will we benefit Oleo from a more precise classification and definition of a non- outjty, a hodgu- podge of human disorders which have charsmeristic.s and manifestations of tissue injury, inflammation and infactian? |
| cord-015021-pol2qm74 | and?-IFN and T- helper-2( Th2) acting principally in inducing antibody formation with a secretion of IL-4, IL-5, IL-10 and TNF-[3 has still to be established within the context of major trauma. |
| cord-015021-pol2qm74 | anti- IFN-?( p<0.05). |
| cord-015021-pol2qm74 | or is it better to use a specific model for each trial? |
| cord-015021-pol2qm74 | ~is s?. |