This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-007101-m0fs2f2a | Is the pig a good model for man? |
| cord-009614-lbjesv8y | How does HIV cause AIDS? |
| cord-002933-zmx4k46v | Why do dengue viruses universally cleave human but not monkey STING? |
| cord-007843-yqdqm4rh | Unique challenges of hepatitis C in infants, children, and adolescents Hepatitis C management simplification from test to cure: a framework for primary care providers Live attenuated influenza vaccine: is past performance a guarantee of future results? |
| cord-004222-z4butywi | priming a broadly neutralizing antibody response to HIV-1 using a germline targeting immunogen Identification of common features in prototype broadly neutralizing antibodies to HIV envelope V2 apex to facilitate vaccine design High- throughput immune repertoire analysis with IGoR Estimating the population size for capture- recapture data with unequal catchability How many different clonotypes do immune repertoires contain? |
| cord-005159-6agnsbyd | Citizenship Studies Vulnerability: What kind of principle is it? |
| cord-016292-o4cw5ufy | a challenge for the veterinary profession Is that a rodent in your luggage? |
| cord-017752-ofzm3x3a | A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma Is cancer dangerous to the immune system? |
| cord-010570-ytv7dwr0 | Does intravenous immune globulin have a role in HIV- infected patients? |
| cord-196608-k4f79dr4 | R&D Systems Covid-19 and angiotensin- converting enzyme inhibitors and angiotensin receptor blockers: what is the evidence? |
| cord-000235-782iew86 | Emerging respiratory agents: new viruses for old diseases? |
| cord-000235-782iew86 | developing evidence for pathogenicity Human bocavirus infection in young children in the United States: molecular epidemiological profile and clinical characteristics of a newly emerging respiratory virus Epidemiological profile and clinical associations of human bocavirus and other human parvoviruses Frequent detection of human rhinoviruses, paramyxoviruses, coronaviruses, and bocavirus during acute respiratory tract infections Human bocavirus: clinical significance and implications Serodiagnosis of human bocavirus infection Human bocavirus: passenger or pathogen in acute respiratory tract infections? |
| cord-010046-7hlgjiqp | tuberculosis H37Rv and its implication in toll- like receptor response Are proton transfer reactions of excited states involved in UV laser desorption ionization? |
| cord-030748-780dcjo1 | Why Are Some Driver Mutations Rare? |
| cord-022381-x15ki4xv | Local production of IgG4 in human colostrum IgD- A mucosal immunoglobulin? |
| cord-015613-ls9qus8y | But which way is forward? |
| cord-015613-ls9qus8y | Is infectious disease generally a matter for concern by conservation biologists? |
| cord-254592-wa5il5go | The Lancet Estimates of Ebola virus case- fatality ratio in the 2014 West African outbreak Current knowledge on lower virulence of Reston Ebola virus Prediction and prevention of the next pandemic zoonosis Host- parasite relations, vectors, and the evolution of disease severity Pathogen survival in the external environment and the evolution of virulence Mechanisms of pathogenesis, infective dose and virulence in human parasites Challenging the trade- off model for the evolution of virulence: is virulence management feasible? |
| cord-254559-3kgfwjzd | Why do farmers and veterinarians not report all bovine abortions, as requested by the clinical brucellosis surveillance system in France? |
| cord-255137-utg8k7qs | The ascension of wildlife rabies: a cause for public health concern or intervention? |
| cord-005872-w1x1i0im | Does elevated nitric oxide production enhance the release of prostacyclin from shear stressed aortic endothelial cells? |
| cord-005872-w1x1i0im | To block or enhance its production during sepsis? |
| cord-016839-cqtpj3m0 | One may ask: why'securitise'intellectual property? |
| cord-016839-cqtpj3m0 | What then, is the relationship between IP and the security of the individual, the state, and the international community? |
| cord-016364-80l5mua2 | A virus( H5N1) infection in cats causes systemic disease with potential novel routes of virus spread within and between hosts Avian H5N1 infl uenza in cats Feline friend or potential foe? |
| cord-016364-80l5mua2 | SARS- associated coronavirus Characterization of a novel coronavirus associated with severe acute respiratory syndrome Unique and conserved features of genome and proteome of SARS- coronavirus, an early split- off from the coronavirus group 2 lineage Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus Animal- to- human SARS- associated coronavirus transmission? |
| cord-010977-fwz7chzf | A pilot study Newly expressed SUR1-regulated NC(Ca- ATP) channel mediates cerebral edema after ischemic stroke Sulfonylurea receptor 1 expression in human cerebral infarcts Does inhibiting Sur1 complement rt- PA in cerebral ischemia? |
| cord-010977-fwz7chzf | Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions Very early administration of progesterone for acute traumatic brain injury Embracing failure: What the Phase III progesterone studies can teach about TBI clinical trials Mitochondria- wide association study of common variants in osteoporosis Genetic association studies in cardiovascular diseases: Do we have enough power? |
| cord-016990-ot1wi3xi | : a review of ten years'experience Pulmonary complications of solid organ and hematopoietic stem cell transplantation Lungs are a major organ site of cytomegalovirus latency and recurrence Spectrum of pulmonary diseases associated with the acquired immune deficiency syndrome Cytomegalovirus- induced alveolar hemorrhage in patients with AIDS: a new clinical entity? |
| cord-016990-ot1wi3xi | How do viral infections predispose patients to bacterial infections? |
| cord-018437-yjvwa1ot | The size and conformation of Kaposi's sarcoma- associated herpesvirus( human herpesvirus 8) DNA in infected cells and virions Characterization of a novel coronavirus associated with severe acute respiratory syndrome Nucleotide sequence of the Kaposi sarcoma- associated herpesvirus( HHV8) Human bocavirus: passenger or pathogen in acute respiratory tract infections? |
| cord-018437-yjvwa1ot | What does virus evolution tell us about virus origins? |
| cord-022955-vy0qgtll | A key question is how is the multi- ubiquitin chain is recognized as a signal? |
| cord-022955-vy0qgtll | Is this brain protease involved in the pathomechanism of multiple sclerosis? |
| cord-023647-dlqs8ay9 | If and Sequence Similarity to Yeast Pt~2 StguCttU'e and Evolution of the 02 Small Nuclear RNA Multigene Family in Primates: Gene Amplification Under Nat-¢wal Selectinn? |
| cord-023647-dlqs8ay9 | Transcription Factors An Element of Symmetry in Ytmst TATA- box Binding Protein Transcription Factor- liD--Consequence of an Ancestra/ Duplication? |
| cord-022393-s26d54ew | A new zoonosis? |
| cord-022393-s26d54ew | In Principles and practices of infectious diseases Laboratory animal allergy in a pharmaceutical company Important animal allergens are lipocalin proteins: why are they allergenic? |
| cord-002728-6oyw5sqv | Environ Microbiol Rep Exploiting gut bacteriophages for human health Characterization of a bacteriophage- derived murein peptidase for elimination of antibiotic- resistant Staphylococcus aureus Ecology of prokaryotic viruses Bacteriophage receptors, mechanisms of phage adsorption and penetration into host cell Comparative( meta)genomic analysis and ecological profiling of human gut- specific bacteriophage φB124- 14 CRISPR targeting reveals a reservoir of common phages associated with the human gut microbiome Dysbiosis in inflammatory bowel disease: a role for bacteriophages? |
| cord-002728-6oyw5sqv | Here a virus, there a virus, everywhere the same virus? |
| cord-002728-6oyw5sqv | What are exosomes, exactly? |
| cord-020764-5tq9cr7o | The three- dimensional question: can clinically relevant tumor drug resistance be measured in vitro? |
| cord-020764-5tq9cr7o | This begs the question how can cell culture, because of its reductionist nature only dealing with a minimal number of variables, help to solve the unknown questions and decipher the components involved in disease? |
| cord-016313-n4ewq0pt | Neuroprotective effect of combined hypoxia- induced VEGF and bone marrowderived mesenchymal stem cell treatment Complete knockdown of CCR5 by lentiviral vector- expressed siRNAs and protection of transgenic macrophages against HIV-1 infection Speci fi c transduction of HIV- susceptible cells for CCR5 knockdown and resistance to HIV infection: a novel method for targeted gene therapy and intracellular immunization Stem cells and reprogramming: breaking the epigenetic barrier? |
| cord-016313-n4ewq0pt | TGF{beta}/ TNF{alpha}-mediated epithelial- mesenchymal transition generates breast cancer stem cells with a claudin- low phenotype Genetically engineered mesenchymal stem cells: applications in spine therapy Hyaluronan and mesenchymal stem cells: from germ layer to cartilage and bone Notch signaling as gatekeeper of rat acinar- to- beta- cell conversion in vitro Transplantation of human bone marrow- derived mesenchymal stem cells promotes Will there be a live- attenuated HIV vaccine available for human safety trials by the year 2000? |
| cord-027885-ua8miwes | The human skin microbiome Supplementation of diet with galactooligosaccharides increases bifidobacteria, but not insulin sensitivity, in obese prediabetic individuals Prebiotic dietary fiber and gut health: comparing the in vitro fermentations of beta- glucan, inulin and Xylooligosaccharide Colorectal cancer cells increase the production of short chain fatty acids by Propionibacterium freudenreichii impacting on cancer cells survival Estrogen and microbiota crosstalk: should we pay attention? |
| cord-027885-ua8miwes | The lung microbiome in health and disease Antibiotic- induced shifts in fecal microbiota density and composition during hematopoietic stem cell transplantation Comparison of the respiratory microbiome in healthy nonsmokers and smokers Average genome size estimation improves comparative metagenomics and sheds light on the functional ecology of the human microbiome Gut microbiota and probiotics intervention: a potential therapeutic target for management of cardiometabolic disorders and chronic kidney disease? |
| cord-253844-y6xdcf20 | SARS coronavirus entry into host cells through a novel clathrin- and caveolae- independent endocytic pathway Targeting the endocytic pathway and autophagy process as a novel therapeutic strategy in COVID-19 The lung macrophage in SARS- CoV-2 infection: a friend or a foe? |
| cord-253844-y6xdcf20 | why 2 meters/6 feet of inter- personal distance could not be enough Consideration of the aerosol transmission for COVID-19 and public health Asymptomatic carriage and transmission of SARS- CoV-2: what do we know? |
| cord-274241-biqbsggu | why bats? |
| cord-255181-du6rqc6i | -a threat under control? |
| cord-255181-du6rqc6i | Wet markets-a continuing source of severe acute respiratory syndrome and influenza? |
| cord-265857-fs6dj3dp | how big? |
| cord-265857-fs6dj3dp | how fast? |
| cord-267149-5twx9y5c | This correlation suggests that TfR1 use is a key determinant in the virulence of clade B viruses, which raises an important question: how easily might clade B viruses circulating in animals gain the ability to use human TfR1? |
| cord-016743-k5plq0ja | Accordingly, the key question that should be asked is:"Is the transdermal route suitable and required for the proposed therapeutic agent?" |
| cord-016743-k5plq0ja | The barrier function of the skin in relation to percutaneous absorption of drugs Formulating for efficacy Antioxidants and skin: an overview Intra- articular drug delivery from an optimized topical patch containing teriflunomide and lornoxicam for rheumatoid arthritis treatment: does the topical patch really enhance a local treatment? |
| cord-016743-k5plq0ja | The iontophoresis of fentanyl citrate in humans Cutaneous vaccination: the skin as an immunologically active tissue and the challenge of antigen delivery Development and evaluation of a microemulsion formulation for transdermal delivery of terbinafine Transdermal drug delivery in pain management Is transdermal drug delivery research still important today? |
| cord-016657-w30hed7w | Are specifi c routes important, or should only destinations be considered? |
| cord-016657-w30hed7w | For instance, is the study interested in the sites where individuals spend their time on a 8.3 Geographic Considerations in Human Movement regular basis( high spatial and temporal resolution) or when they are traveling outside of their home city? |
| cord-016657-w30hed7w | What is the value of travel information( outside of an urban area) that specifi es exactly where people go? |
| cord-288119-3zq8l5z0 | Fields Virology, 5 A new virus isolated from the human respiratory tract Recovery in tracheal organ cultures of novel viruses from patients with respiratory disease Characterization of a novel coronavirus associated with severe acute respiratory syndrome Identification of a novel coronavirus in patients with severe acute respiratory syndrome Identification of a new human coronavirus Phylogenetic and recombination analysis of coronavirus HKU1, a novel coronavirus from patients with pneumonia Human coronaviruses: what do they cause? |
| cord-017675-in9r33ww | Do human rights matter to health? |
| cord-017675-in9r33ww | HIV Risk Behavior? |
| cord-017675-in9r33ww | How much revenue will a pharmaceutical company generate in each of the following scenarios? |
| cord-009792-e2vvi8qo | How far can sequences diverge? |
| cord-009792-e2vvi8qo | How representative are the known structures of the proteins in a complete genome? |
| cord-009792-e2vvi8qo | Predicting structures for genome proteins From protein structure to function Genomic- scale comparison of sequence- and structure- based methods of function prediction: Does structure provide additional insight? |
| cord-272955-kkkrkgg1 | A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequence Neurologic disease due to adenovirus infection Characterizations of adenovirus type 41 isolates from children with acute gastroenteritis in Japan, Vietnam, and Korea Two RT- PCR based assays to detect human matapneumovirus in nasopharyngeal aspirates Severe pneumonia due to adenovirus serotype 14: a new respiratory threat? |
| cord-017527-ylng1us2 | : how aware are Mammalian cell culturists of the problem and how to monitor it? |
| cord-017527-ylng1us2 | A novel coronavirus associated with SARS Cell culture contamination: an overview Improving the biosafety of cell sorting by adaptation of a cell sorting system to a biosafety cabinet Bovine viral diarrhea virus contamination of nutrient serum, cell cultures and viral vaccines Ocular vaccinia infection in laboratory worker A tale of two clades: monkeypox viruses Molecular cloning and disease association of hepatitis G virus: a transfusion- transmissible agent Infection of laboratory workers with hantavirus acquired from immunocytomas propagated in laboratory rats Cross- species transfer of viruses: implications for the use of viral vectors in biomedical research, gene therapy and as live- virus vaccines Henrietta Lacks, HeLa cells, and cell culture contamination CD4-independent infection by human immunodeficiency virus type I after phenotypic mixing with human T- cell leukemia viruses Where all the cell lines gone? |
| cord-017527-ylng1us2 | Brief report, infections of a laboratory worker with simian immunodeficiency virus How long do nosocomial pathogens persist on inanimate surfaces? |
| cord-253548-izya7nws | COVID-19: What can human factors and ergonomics offer? |
| cord-253548-izya7nws | Will human factors restore faith in the GMC? |
| cord-007726-bqlf72fe | Allergic airway inflammation initiates long- term vascular remodeling of the pulmonary circulation Respiratory allergy caused by house dust mites: what do we really know? |
| cord-007726-bqlf72fe | The laboratory mouse A comparative encyclopedia of DNA elements in the mouse genome Principles of regulatory information conservation between mouse and human Of mice and men: aligning mouse and human anatomies Mouse models of human disease: an evolutionary perspective Structure and composition of pulmonary arteries, capillaries, and veins Angiogenesis in the mouse lung Lung cancer perfusion: can we measure pulmonary and bronchial circulation simultaneously? |
| cord-007726-bqlf72fe | The transition from primary culture to spontaneous immortalization in mouse fibroblast populations Studying human respiratory disease in animals-role of induced and naturally occurring models Role of mast cells in allergic and non- allergic immune responses: comparison of human and murine data Allergic airway inflammation induces migration of mast cell populations into the mouse airway Novel site- specific mast cell subpopulations in the human lung Animal models of asthma: reprise or reboot? |
| cord-007726-bqlf72fe | What Does the Future Hold for Mouse Models of Human Disease? |
| cord-264031-0y7xbgun | I deficiency? |
| cord-264031-0y7xbgun | Who is most likely to be infected with SARS- CoV-2? |
| cord-272405-jmwn8pdn | when and why? |
| cord-001427-qw1e5cof | Methicillin- resistant Staphylococcus aureus in animals Does broad- spectrum β- lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gram- negative bacteria? |
| cord-001427-qw1e5cof | The European Union summary report on trends and sources of zoonoses, zoonotic agents and food- borne outbreaks in 2011 Fecal carriage and shedding density of CTX- M extended- spectrum ß- lactamaseproducing Escherichia coli in cattle, chickens, and pigs: implications for environmental contamination and food production Emergence of methicillin- resistant Staphylococcus aureus( MRSA) in different animal species Methicillin- resistant Staphylococcus aureus in food products: cause for concern or case for complacency? |
| cord-001427-qw1e5cof | The components of'One World-One Health'approach Animal associated opportunistic infections among persons infected with the human immunodeficiency virus Biofilms in oral cavity of dogs and implication in zoonotic infections Sensitive populations: who is at the greatest risk? |
| cord-001427-qw1e5cof | The emergence of Lyme disease Vector transmission of Bartonella species with emphasis on the potential for tick transmission Concurrent infection of the central nervous system by Borrelia burgdorferi and Bartonella henselae: evidence for a novel tick- borne disease complex Cat scratch disease and arthropod vectors: more to it than a scratch? |
| cord-016403-id6fjgye | ( 2) Does the composition of the human microbiome vary from one geographical region to another? |
| cord-016403-id6fjgye | : what's in it for us, and why should we care? |
| cord-016403-id6fjgye | For example, an African component of the human microbiome would provide elements to answering important outstanding microbiome questions, among which are included:( 1) Is there a core human microbiome? |
| cord-016403-id6fjgye | From where did the 2009'swine- origin'influenza A virus( H1N1) emerge? |
| cord-276039-nqqwnmwc | The recent discovery of endogenous viruses, and FV in fishes Overviews of pathogen emergence: which pathogens emerge, when and why? |
| cord-270940-acwkh6ed | Have changes taken place in the viruses themselves? |
| cord-270940-acwkh6ed | Molecular evolution and distribution of dengue viruses type 1 and 2 in nature Epidemiology and clinical features of imported dengue fever in Europe: sentinel surveillance data from TropNetEurop Origins, evolution, and vector/ host coadaptations within the genus Flavivirus Diagnosis of tick- borne encephalitis West Nile virus: a growing concern? |
| cord-270940-acwkh6ed | What are the reasons for the appearance of all these emerging and re- emerging viruses? |
| cord-186405-f9m3e31q | A survey What is an affordance? |
| cord-186405-f9m3e31q | Did you mean this object?: |
| cord-186405-f9m3e31q | gaze communication Turn taking for human- robot interaction Extending end- state comfort effect: Do we consider the beginning state comfort of another? |
| cord-002337-8v907g24 | For example, should we interpret high sustained levels of human spillover as evidence of increased risk because of the number of human infections, or as evidence of decreasing risk because of the number of times the strain has failed to achieve sustained transmission? |
| cord-002337-8v907g24 | Granularity of pandemic risk prediction-for what taxonomic level does it make sense? |
| cord-002337-8v907g24 | More deliberate approaches to the design of surveillance systems would also depend on answering the question addressed in Box 2: how different must a virus be from previously characterized viruses to merit separate evaluation of its pandemic risk? |
| cord-002337-8v907g24 | the next generation How sticky should a virus be? |
| cord-286368-kdwh4hgf | : how do they differ from those in seasonal influenza? |
| cord-017225-6ofi6mg5 | A comparison of the health systems in China and India( RAND, information and interdisciplinary subjects series Chian's health care reform: not just a policy failure, carengie endonwment for international peace Universal coverage of health care in China: challenges and opportunities( world health report Social security of labour in the New Indian economy? |
| cord-017225-6ofi6mg5 | A study of China's legal system for food safety A study of the health care right Chinese vs. Western perspectives: understanding contemporary China Food safety becomes national priority, China Daily What is the right to food? |
| cord-017225-6ofi6mg5 | But then who will take care of the patients? |
| cord-017225-6ofi6mg5 | What are Human Rights? |
| cord-017225-6ofi6mg5 | What is the Right to Food?" |
| cord-282878-8qgsq2km | Can We Do More on Glycemic Control? |
| cord-282878-8qgsq2km | The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1 Viral infections in type 1 diabetes mellitus-- why the β cells? |
| cord-280107-tulne0v3 | A problem or Solution for Conservation? |
| cord-270892-ycc3csyh | Explanation and elaboration Ethnobotany and the search for new drugs: Ciba Foundation Symposium 185 Ethnobotany and natural products: The search for new molecules, new treatments of old diseases or a better understanding of indigenous cultures? |
| cord-270892-ycc3csyh | How contagious are common respiratory tract infections? |
| cord-270892-ycc3csyh | How scientific is the science in ethnopharmacology? |
| cord-020756-d9f5fd7x | H5N1 Virus Attachment to Lower Respiratory Tract Importance of conserved amino acids at the cleavage site of the haemagglutinin of a virulent avian influenza A virus Are we ready for pandemic influenza? |
| cord-020756-d9f5fd7x | Molecular characterization of H9N2 influenza viruses: were they the donors of the"internal"genes of H5N1 viruses in Hong Kong? |
| cord-020756-d9f5fd7x | Nonhomologous recombination between the hemagglutinin gene and the nucleoprotein gene of an influenza virus Influenza A pandemics of the 20th century with special reference to 1918: virology, pathology and epidemiology Virus- neutralizing antibodies of immunoglobulin G( IgG) but not of IgM or IgA isotypes can cure influenza virus pneumonia in SCID mice Functional anatomy of human lacrimal duct epithelium Human infection with influenza H9N2 Cocirculation of avian H9N2 and contemporary"human"H3N2 influenza A viruses in pigs in southeastern China: potential for genetic reassortment? |
| cord-020756-d9f5fd7x | Recent human influenza A( H1N1) viruses are closely related genetically to strains isolated in 1950 Human influenza virus hemagglutinin with high sensitivity to proteolytic activation Avian influenza and sialic acid receptors: more than meets the eye? |
| cord-020756-d9f5fd7x | Will vaccines be available for the next influenza pandemic? |
| cord-018354-o6pmuhd8 | How far has the concept of human security permeated East Asian countries so that stakeholders can jointly address the multiple threats described thus far? |
| cord-018354-o6pmuhd8 | What do Asian countries accept, reject, or remodel of the idea of human security born in the UN? |
| cord-018354-o6pmuhd8 | What is the most important element among the components that make up human security? |
| cord-018354-o6pmuhd8 | Whose Norms Matter? |
| cord-018354-o6pmuhd8 | Why does human security not fade out? |
| cord-276218-dcg9oq6y | : why is this situation a PHEIC? |
| cord-017537-ztdz4a2s | Are we many on Earth? |
| cord-017537-ztdz4a2s | Is there enough work for the immune system of each living multicellular organism to distinguish"self"from possibly harmful"not self"? |
| cord-017537-ztdz4a2s | The basic question is: when the new pandemic will strike? |
| cord-017537-ztdz4a2s | There are no longer cases detected in the world population since 1990, but can we destroy the samples of smallpox virus existing in some virology laboratories around the world? |
| cord-017537-ztdz4a2s | Today, how scared should we be of biological and chemical terrorism? |
| cord-277309-kelebqr6 | : what can they teach us about the severe acute respiratory syndrome? |
| cord-277309-kelebqr6 | A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special? |
| cord-277309-kelebqr6 | Current Opinion in Virology 2019, 34:79- 89 Bats as a continuing source of emerging infections in humans Mass extinctions, biodiversity and mitochondrial function: are bats'special'as reservoirs for emerging viruses? |
| cord-271979-a9u494tr | One of the crucial questions in disease emergence is: What environmental or evolutionary changes cause the R 0 of wildlife viruses to rise above 1 in human populations? |
| cord-271979-a9u494tr | Switzerland and Cambridge, UK: International Union for the Conservation of Nature First confirmed dengue-1 fever cases reported from Cameroon Epidemic of yellow fever in North Cameroon in 1990- 1st isolation of yellow fever virus in Cameroon Current topics in microbiology and immunology Four generations of probable person- to- person transmission of human monkeypox AIDS as a zoonosis: scientific and public health implications Transmissible drug resistance in Shigella and Salmonella isolated from pet monkeys and their owners B- virus from pet macaque monkeys: an emerging threat in the United States? |
| cord-283152-wav0d0ws | The FDA- approved drug ivermectin inhibits the replication of SARS- CoV-2 in vitro Coronavirus disease( COVID-19): a primer for emergency physicians New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? |
| cord-252810-rko3e5va | : a review Organogenesis in a dish: modeling development and disease using organoid technologies Regenerative lineages and immune- mediated pruning in lung cancer metastasis Repairing the lungs one breath at a time: How dedicated or facultative are you? |
| cord-252810-rko3e5va | A Kinase for All Pathways? |
| cord-252810-rko3e5va | A cellular census of human lungs identifies novel cell states in health and in asthma Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury Can stem cells be used to generate new lungs? |
| cord-252810-rko3e5va | Lung microvascular endothelium is enriched with progenitor cells that exhibit vasculogenic capacity Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD Type 2 alveolar cells are stem cells in adult lung Single- cell trajectory detection uncovers progression and regulatory coordination in human B cell development Endogenous lung stem cells: what is their potential for use in regenerative medicine? |
| cord-029209-v2w0i2ex | : What Kind of Law Promotes What Kind of Peace?' |
| cord-029209-v2w0i2ex | Can human security make international law more responsive to human need? |
| cord-029209-v2w0i2ex | The question becomes, are the current international institutions and legal system fit for purpose? |
| cord-029209-v2w0i2ex | What Is the Use of International Law? |
| cord-029209-v2w0i2ex | What is human security? |
| cord-293143-1k170shh | Lung infection by human bocavirus induces the release of profibrotic mediator cytokines in vivo and in vitro Human bocavirus: from common cold to cancer? |
| cord-017364-d9zmdm23 | Does severe RSV disease cause asthma? |
| cord-017364-d9zmdm23 | Is there a genetic basis for susceptibility to severe disease? |
| cord-017364-d9zmdm23 | What are the defi nitive mechanisms of immunity in humans? |
| cord-017364-d9zmdm23 | What drives the seasonality of RSV? |
| cord-017364-d9zmdm23 | Why does reinfection occur throughout life? |
| cord-291909-x0sfwqnk | The interaction of human population, food production, and biodiversity protection Is global collapse imminent? |
| cord-291909-x0sfwqnk | trent modelled by the LTG study( 1970- 2100)( LTG) peak health? |
| cord-274520-c674wkmt | : how infectious is it? |
| cord-274520-c674wkmt | Environmental particulate matter induces murine intestinal inflammatory responses and alters the gut microbiome Ambient air pollution correlates with hospitalizations for inflammatory bowel disease Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome Exposure to trafficrelated air pollution and the composition of the gut microbiota in overweight and obese adolescents Long- term exposure to fine particulate matter and incidence of type 2 diabetes mellitus in a cohort study: effects of total and traffic- specific air pollution e gut microbiota: a major player in the toxicity of environmental pollutants? |
| cord-274520-c674wkmt | e respiratory microbiome: an underappreciated player in the human response to inhaled pollutants? |
| cord-018639-0g1ov96t | An interdisciplinary approach to analysing the bushmeat trade in central and west Human demography and reserve size predict wildlife extinction in West Africa Economic and geographic drivers of wildlife consumption in rural Africa Is the best the enemy of the good? |
| cord-018639-0g1ov96t | The historical question of acquired immunodefi ciency syndrome in the 1960s in the Congo River basin area in relation to cryptococcal meningitis Could risk of disease change bushmeat- butchering behavior? |
| cord-018639-0g1ov96t | The threat to primates and other mammals from the bushmeat trade in Africa, and how this threat could be diminished 1 Economic commodity or environmental crisis? |
| cord-018639-0g1ov96t | Why do Mbuti hunters use nets? |
| cord-018639-0g1ov96t | a disease risk worth taking to put food on the table? |
| cord-261466-b9r4cyp7 | A review of the clinical presentation of dientamoebiasis Transmission of Dientamoeba fragilis: pinworm or cysts? |
| cord-261466-b9r4cyp7 | The lack of precise epidemiological data is indicated by'?'. |
| cord-261466-b9r4cyp7 | What is the importance of zoonotic trichomonads for human health? |
| cord-261466-b9r4cyp7 | isolate from a whitewinged pigeon extremely closely related to isolates of T. vaginalis represent a case of human to bird transfer( accession HM016231 in Figure 2)? |
| cord-257494-242k58ll | : How far are we? |
| cord-257494-242k58ll | In light of this scarce resistance mechanisms de novo acquisition, what mechanisms do bacteria naturally develop/ possess against ABPs? |
| cord-257494-242k58ll | Pore formers or metabolic inhibitors in bacteria? |
| cord-257494-242k58ll | Structural relationship between human salivary histatins Zinc and copper bind to unique sites of histatin 5 Is salivary histatin 5 a metallopeptide? |
| cord-025998-1qawjquv | A Tale of Two Hemispheres Ecology of Rickettsia in South America Rickettsia species infecting Amblyomma cooperi ticks from an area in the state of Sao Paulo, Brazil, where Brazilian spotted fever is endemic Environmental parasitology: what can parasites tell us about human impacts on the environment? |
| cord-025998-1qawjquv | Are vibrios in sediment part of a benthic community with its own character istics or do they basically consist of a fraction of a pelagic population reaching the sediment after sedimentation of the particles to which they are attached? |
| cord-025998-1qawjquv | The role of Lymnaea auricularia( Linnaeus) and Lymnaea peregra( Müller)( Gastropoda: Pulmonata) in the transmission of larval digeneans in the Lower Thames Valley Background state leading to arsenic accumulation in the Bengal Basin groundwater What is their actual role in the spread of the virus? |
| cord-025998-1qawjquv | The role of birds in the ecology of West Nile virus in Europe and Africa A short introduction-what is schistosomiasis? |
| cord-025998-1qawjquv | the amyotropic lateral sclerosis/ parkinsonism dementia complex( ALS/ PDC) of Guam have new implications for global health? |
| cord-301935-0qjo94ty | A functional CFTR assay using primary cystic fibrosis intestinal organoids Patient- derived pancreas- on- achip to model cystic fibrosis- related disorders Human Nasal Epithelial Organoids for Therapeutic Development in Cystic Fibrosis Long- term expanding human airway organoids for disease modeling Idiopathic Pulmonary Fibrosis Acute exacerbation of idiopathic pulmonary fibrosis: lessons learned from acute respiratory distress syndrome? |
| cord-256537-axbyav1m | But, what of influenza? |
| cord-256537-axbyav1m | Is it simply that we are more able, with our new technologies, to detect them? |
| cord-256537-axbyav1m | Or are there forces at work that are fostering this trend? |
| cord-256537-axbyav1m | So what explains the apparent increased pace of emergence of new human infections? |
| cord-306535-j26eqmxt | Isolation and morphological characterization Integrative characterization of germ cell- specific genes from mouse spermatocyte UniGene library Comparative and functional analysis of testis- specific genes Genome engineering uncovers 54 evolutionarily conserved and testis- enriched genes that are not required for male fertility in mice Reaching for high- hanging fruit in drug discovery at protein- protein interfaces Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation Catalytic in vivo protein knockdown by small- molecule PROTACs Hijacking the E3 ubiquitin ligase cereblon to efficiently target BRD4 Lessons in PROTAC design from selective degradation with a promiscuous warhead Assessing different E3 ligases for small molecule induced protein ubiquitination and degradation Cell- penetrating peptides: 20 years later, where do we stand? |
| cord-305302-go87uu06 | How can we define such emerging entities? |
| cord-297579-ohpm5ys0 | Where are we now? |
| cord-297579-ohpm5ys0 | ribavirin effectively inhibit Norwalk virus replication in replicon- bearing cells Crystal structures of murine norovirus-1 RNA- dependent RNA polymerase in complex with 2-thiouridine or ribavirin Mechanism of action of interferon and ribavirin in treatment of hepatitis C Ribavirin's antiviral mechanism of action: lethal mutagenesis? |
| cord-298369-66ifwtlp | Do we need to optimize plasma and tissue binding in drug discovery? |
| cord-277076-yvsyo4l9 | Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets Bats, civets and the emergence of SARS Wet marketsÀA continuing source of severe acute respiratory syndrome and influenza? |
| cord-277076-yvsyo4l9 | Interest soon focused on these early index cases: was there any characteristic these patients had in common that could point to a source of their SARS- CoV infection? |
| cord-277076-yvsyo4l9 | Is the fact that the first pandemic of the twenty- first century was quickly contained reason to take comfort in the knowledge that the history of humankind has reached a phase in which biomedical sciences and information technology are able to deal with such threats? |
| cord-277076-yvsyo4l9 | The evolvability of emerging viruses Development of antiviral therapy for severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection Identification of a novel coronavirus in patients with severe acute respiratory syndrome Severe acute respiratory syndrome: Identification of the etiological agent Evaluation of advanced reverse transcription- PCR assays and an alternative PCR target region for detection of severe acute respiratory syndrome- associated coronavirus Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China Bats are natural reservoirs of SARS- like coronaviruses Viral zoonosesÀA threat under control? |
| cord-282628-6uoberfu | How do the virulence factors of shigella work together to cause disease? |
| cord-282628-6uoberfu | What is flux balance analysis? |
| cord-282925-efkb8hc7 | Are we prepared to steer this path together? |
| cord-282925-efkb8hc7 | Melbourne artist Patricia Piccinini( 2020) made this point clearly with her new public art campaign about the bat- boy Are we capable of becoming this kind of posthuman caring hearts? |
| cord-282925-efkb8hc7 | To become a"we"-the missing people? |
| cord-018151-5su98uan | Toward an Anthropology of Viral Hemorrhagic Fevers'Human Extinction and the Pandemic Imaginary Seeing Cellular Debris, Remembering a Soviet Method'Blaming the Rat? |
| cord-018151-5su98uan | Understanding Multiple and Contradictory Human- Rat Relations as Situated Practices Blaming the Rat? |
| cord-018151-5su98uan | What Is an Epidemic? |
| cord-018151-5su98uan | What if infected rats moved from the rural hotspots of the epidemic into urban areas, transforming them into the equivalents of plague- ravaged Bombay on English soil? |
| cord-018151-5su98uan | n't We Got Right to the Tree of Life?','constrast[ed] with images of women afraid of rats; the woman's grip on the rat suggests determination, courage and fury'. |
| cord-018151-5su98uan | the Balance Blaming the Rat? |
| cord-294812-nnlzwaf1 | The aetiology of tuberculosis( translation of Die Aetiologie der Tuberculose( 1882) Sequence- based identification of microbial pathogens: a reconsideration of Koch's postulates The environment and disease: association or causation? |
| cord-294812-nnlzwaf1 | Viral infections in immunocompromised patients: what's new with respiratory viruses? |
| cord-294812-nnlzwaf1 | Viruses associated with pneumonia in adults Emerging respiratory agents: new viruses for old diseases? |
| cord-290548-0wezrr1b | A pandemic warning? |
| cord-290548-0wezrr1b | title: Villains or heroes? |
| cord-104317-t30dg6oj | : next- generation sequencing applied to phage populations in the human gut GB Virus C/ Hepatitis G Virus Infection: A Favorable Prognostic Factor in Human Immunodeficiency Virus- Infected Patients? |
| cord-104317-t30dg6oj | Culture An inquiry into the causes and effects of the variolae vaccinae, a disease discovered in some of the western counties of England, particularly Gloucestershire, and known by the name of the cow pox Coevolution of hosts and parasites Vertical transmission of viruses What is a quasispecies? |
| cord-104317-t30dg6oj | Phage Therapy in the Food Industry Complete nucleotide sequences of four dsRNAs associated with a new chrysovirus infecting Aspergillus fumigatus Mycoviruses: future therapeutic agents of invasive fungal infections in humans? |
| cord-104317-t30dg6oj | Positional cloning of the mouse retrovirus restriction gene Fv1 Rmcf2, a xenotropic provirus in the Asian mouse species Mus castaneus, blocks infection by polytropic mouse gammaretroviruses From ancestral infectious retroviruses to bona fide cellular genes: Role of the captured syncytins in placentation Retroviruses and the Placenta Retroviral gene therapy: safety issues and possible solutions Decade- Long Safety and Function of Retroviral- Modified Chimeric Antigen Receptor T Cells Bacteriophage adhering to mucus provide a non- host- derived immunity Reinventing phage therapy: are the parts greater than the sum? |
| cord-104317-t30dg6oj | Public Health and Medical Uncertainty Current and emerging infectious risks of blood transfusions AIDS pathogenesis: what have two decades of HIV research taught us? |
| cord-104317-t30dg6oj | While the virus has a safe home during persistence, the question arises that if a virus is not replicating, or is present at very low levels, how is it transmitted to the next host? |
| cord-017188-d3xg05ty | Do the diamagnetic( decomposition or transformed) products of a spin trap adduct accumulate to sufficient levels for detection by NMR? |
| cord-017188-d3xg05ty | Does the resultant NMR spectrum allow extrapolation back to a specific radical adduct? |
| cord-017188-d3xg05ty | In vivo evidence of free radical formation in the rat lung after exposure to an emission source air pollution particle Consequences of nitric oxide generation in epileptic- seizure rodent models as studied by in vivo EPR Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content? |
| cord-017188-d3xg05ty | Is cocoa the best beverage? |
| cord-017188-d3xg05ty | The retinal pigmented epithelium is required for development and maintenance of the mouse neural retina Cell- free hemoglobin limits nitric oxide bioavailability in sicklecell disease Low levels of reactive oxygen species as modulators of cell function How many mutations are required for tumorgenesis? |
| cord-017188-d3xg05ty | The roles of neuromelanin, binding of metal ions, and oxidative cytotoxicity in the pathogenesis of Parkinson's disease: a hypothesis Is the incidence of registrable age- related macular degeneration increasing? |
| cord-017188-d3xg05ty | What's the use of generating melanin? |
| cord-005080-r01ii1bu | A new conceptual base for food and agricultural policy: the emerging model of links between agriculture, food, health, environment and society What drives societal collapse? |
| cord-005080-r01ii1bu | Entrapment: global ecological and/or local demographic? |
| cord-005080-r01ii1bu | I may have allowed the emergence of''Spanish''influenza Cholera dynamics and El Niñ o- Southern Oscillation Effects of environmental change on emerging parasitic diseases Malaria's beginnings: on the heels of hoes? |
| cord-005080-r01ii1bu | Millennium Ecosystem Assessment From metaphor to measurement: resilience of what to what? |
| cord-005080-r01ii1bu | Pan African group takes lead against the tsetse fly Lyme disease and the passenger pigeon? |
| cord-005080-r01ii1bu | The new nature of nation- state failure Development as Freedom Changes in life expectancy in Russia in the 1990s Rapid economic growth and the four Ds of disruption, deprivation, disease and death: public health lessons from 19th- century Britain for 21st- century China? |
| cord-005080-r01ii1bu | methodological individualism, rational choice and the political economy of war Geology of mankind Are existing global scenarios consistent with ecological feedbacks? |
| cord-292075-t9z7zqz4 | Quelle sera l'influence du changement climatique sur les diffusions des maladies émergentes? |
| cord-292075-t9z7zqz4 | la voie digestive à partir de la viande de singe mal cuite est- il possible? |
| cord-292075-t9z7zqz4 | épidémique du VIH dans les années 80? |
| cord-309301-ai84el0j | Carcinoma of the gallbladder-- is it a sequel of typhoid? |
| cord-304073-f3iwclkm | Is there an ideal animal model for SARS? |
| cord-304073-f3iwclkm | What is the predictive value of animal models for vaccine efficacy in humans? |
| cord-016293-pyb00pt5 | : Is There Ample Evidence? |
| cord-016293-pyb00pt5 | According to anecdotal evidence when visiting his namesake centre, Sanger asked:"What does this machine do then?""Dideoxy sequencing"came the reply, to which Fred retorted:"Have n't they come up with anything better yet?" |
| cord-016293-pyb00pt5 | According to anecdotal evidence when visiting his namesake centre, Sanger asked:"What does this machine do then?""Dideoxy sequencing"came the reply, to which Fred retorted:"Have n't they come up with anything better yet?" |
| cord-016293-pyb00pt5 | Issues of justice and resource allocation also have been raised: In a time of strain on our health care system, can we afford such expensive therapy? |
| cord-016293-pyb00pt5 | That finding led plant pathologist Roger Beachy, then at Washington University in Saint Louis, to wonder exactly how such"cross- protection"worked-did part of the virus prompt it? |
| cord-016293-pyb00pt5 | When Steve Fodor was asked in 2003"How do you really take the Human genome sequence and transform it into knowledge?" |
| cord-016293-pyb00pt5 | Who should receive gene therapy? |
| cord-320283-nkb9nzyt | Escaping Pandora's box: another novel coronavirus Johns Hopkins Coronavirus Resource Center Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? |
| cord-319044-5otz2w9v | Whence the next pandemic? |
| cord-300793-tuq8z6gm | The challenge of emerging and re- emerging infectious diseases Environmental and social influences on emerging infectious diseases: past, present and future Mortality trends and setbacks: global convergence or divergence? |
| cord-300793-tuq8z6gm | The injection century: massive unsterile injections and the emergence of human pathogens Mortality before and after HIV infection in the complete UK population of haemophiliacs Transmission of West Nile virus through blood transfusion in the United States in 2002 Transmission of West Nile virus from an organ donor to four transplant recipients Cell and molecular biology of simian virus 40: implications for human infections and disease SV40 in human cancers- an endless tale? |
| cord-300793-tuq8z6gm | What have we learnt from SARS? |
| cord-004879-pgyzluwp | A50$ 14- 28 Neutralization rates of TNF- a from eight animal species by a monoclonal antibody against human TNF: implication for receptor action? |
| cord-004879-pgyzluwp | Are these two activities encoded by a single mRNA? |
| cord-004879-pgyzluwp | Do their protein- chemical structure and organisation decipher us certain clues and parts of the path by which they have been selected and derived from a possible primordial reaction centre polypeptide? |
| cord-004879-pgyzluwp | Does the ALEP1 germ- line specific protein have a homologue in the somatic ribosomes? |
| cord-004879-pgyzluwp | However, in the presence of 1000 U/ ml interferon? |
| cord-004879-pgyzluwp | Is membranebound enzyme preferentially associated with a given cellular membrane? |
| cord-004879-pgyzluwp | What is the function of rpS 19? |
| cord-300301-7amiljnm | -where did it come from and where might it go? |
| cord-300301-7amiljnm | European Centre for disease prevention and control swine flu guidelines:'cough hygienically'into your sleeve? |
| cord-300301-7amiljnm | Philos Is exposure to sick or dead poultry associated with flulike illness? |
| cord-035138-7v92aukg | Are We Finally on the Edge of a New Frontier? |
| cord-035138-7v92aukg | Is n't this what the acclaimed Universal Health Coverage( UHC) approach ultimately aims for? |
| cord-035138-7v92aukg | Understanding Questions and Answers about Covid-19 Vaccination Mapping 123 million neonatal Reflections on the Global Burden of Disease 2010 Estimates Disease burden in sub- Saharan Africa: What should we conclude in the absence of data? |
| cord-035138-7v92aukg | What's the point of describing COVID in Argentina merely counting the number of cases, without telling people's stories, without understanding the different human groups, their identities and challenges? |
| cord-035138-7v92aukg | When Will We Have a Vaccine? |
| cord-035138-7v92aukg | cord-035138- 7v92aukg authors: Tognoni, Gianni; Macchia, Alejandro title: Health as a Human Right: A Fake News in a Post- human World? |
| cord-035138-7v92aukg | what then?' |
| cord-312807-8v4r9jij | A comparison of bats and rodents as reservoirs of zoonotic viruses: Are bats special? |
| cord-312807-8v4r9jij | Why has zoonotic tuberculosis not received much attention? |
| cord-256615-gvq8uyfk | How can we be better prepared to identify emerging pathogens early? |
| cord-256615-gvq8uyfk | How many pathogenic viruses remain to be discovered? |
| cord-256615-gvq8uyfk | Is it feasible to predict which animal viruses have the potential to cause disease in humans? |
| cord-256615-gvq8uyfk | The global distribution and burden of dengue Airborne transmission of influenza A/ H5N1 virus between ferrets Role of receptor binding specificity in influenza A virus transmission and pathogenesis Venezuelan equine encephalitis emergence: enhanced vector infection from a single amino acid substitution in the envelope glycoprotein Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come? |
| cord-256615-gvq8uyfk | The human virome: new tools and concepts Human polyomaviruses in disease and cancer Bats and their virome: an important source of emerging viruses capable of infecting humans Overviews of pathogen emergence: which pathogens emerge, when and why? |
| cord-256615-gvq8uyfk | What is the best strategy for identifying and limiting the menace from novel, zoonotic viruses? |
| cord-284711-l1za83w1 | And, third, security for whom? |
| cord-284711-l1za83w1 | Are no- suicide contracts eff ective in preventing suicide in suicidal patients seen by primary care physicians? |
| cord-284711-l1za83w1 | First, protection of what? |
| cord-284711-l1za83w1 | Paper presented at Common Security Forum Conference Concepts of human development and poverty: a multidimensional perspective Human security now: protecting and empowering people Commodities and capabilities Why human security? |
| cord-284711-l1za83w1 | Second, insurance against what? |
| cord-284711-l1za83w1 | The third question concerns security for whom- the entire population or a subset of it? |
| cord-333405-ji58jbct | The origins of acquired immune deficiency viruses: where and when? |
| cord-264408-vk4lt83x | ( l- sIGN) is a receptor for severe acute respiratory syndrome coronavirus Glycomic characterization of respiratory tract tissues of ferrets: implications for its use in influenza virus infection studies Comparative analysis of monkeypox virus infection of cynomolgus macaques by the intravenous or intrabronchial inoculation route Phenotypic changes in langerhans'cells after infection with arboviruses: a role in the immune response to epidermally acquired viral infection? |
| cord-264408-vk4lt83x | A novel model of lethal Hendra virus infection in African green monkeys and the effectiveness of ribavirin treatment Clinical outcome of henipavirus infection in hamsters is determined by the route and dose of infection recent progress in henipavirus research: molecular biology, genetic diversity, animal models Mucosal arenavirus infection of primates can protect them from lethal hemorrhagic fever sArs vaccines: where are we? |
| cord-264408-vk4lt83x | A simple technique for infection of mosquitoes with viruses; transmission of Zika virus Human papillomavirus research: do we still need animal models? |
| cord-264408-vk4lt83x | An unusual hantavirus outbreak in southern Argentina: person- to- person transmission? |
| cord-264408-vk4lt83x | emerg sArs: what have we learned? |
| cord-307320-fxs31d66 | Antibacterial properties of Pseudomonas aeruginosa immunotype 1 lipopolysaccharidespecific monoclonal antibody( MAb) in a murine thigh infection model: combined effects of MAb and ceftazidime Defining the complementarities between antibodies and haptens to refine our understanding and aid the prediction of a successful binding interaction Single- domain llama antibodies as specific intracellular inhibitors of SpvB, the actin ADP- ribosylating toxin of Salmonella typhimurium Genetic and immunological comparison of anti- botulinum type A antibodies from immune and non- immune human phage libraries In vivo neutralization of botulinum neurotoxins serotype E with heavy- chain camelid antibodies( VHH) Shark novel antigen receptors- the next generation of biologic therapeutics? |
| cord-307320-fxs31d66 | Potent neutralization of botulinum neurotoxin by recombinant oligoclonal antibody Markedly prolonged incubation period of hepatitis B in a chimpanzee passively immunized with a human monoclonal antibody to the a determinant of hepatitis B surface antigen Monoclonal antibodies in man that neutralized H3N2 influenza viruses were classified into three groups with distinct strain specificity Antibacterial monoclonal antibodies: back to the future? |
| cord-018017-c8myq6bi | If infections are the greatest threat to human life, they should be critical drivers of evolution? |
| cord-018017-c8myq6bi | In fact, why study anything that is not the most highly impactful area? |
| cord-018017-c8myq6bi | Most prominent was, why study an area of science that has no significant impact? |
| cord-018017-c8myq6bi | On which disease should we focus? |
| cord-018017-c8myq6bi | This question demands a definition, what constitutes high impact? |
| cord-018017-c8myq6bi | What presents the greatest threat to human life today? |
| cord-018017-c8myq6bi | Why not? |
| cord-306056-4jx0u7js | A clinician asks the daughter of a comatose patient,''What would your mother, Mrs. Penelope Smith, have wanted in terms of life sustaining treatment if she were able to speak to us today?'' |
| cord-306056-4jx0u7js | How might the concept of natural kinds bridge the gap between the common sense essentialism of clinicians and the philosophy of medicine? |
| cord-306056-4jx0u7js | Thus, my 4- 1/2 year old nephew asks,''Do I have a splinter, Uncle Danny?'' |
| cord-289626-8oldaa8i | : where are the gaps in our understanding of primate infectious diseases? |
| cord-289626-8oldaa8i | : why is human well- being increasing as ecosystem services degrade? |
| cord-289626-8oldaa8i | Can you judge a disease host by the company it keeps? |
| cord-289626-8oldaa8i | Gap analysis and the geographical distribution of parasites Does the impact of biodiversity differ between emerging and endemic pathogens? |
| cord-289626-8oldaa8i | The ecology of Ebola virus Rapoport's rule apply to human associated pathogens? |
| cord-306904-8iteddug | Properties of the decarboxylated gamma- carboxyglutamic acid protein from calf bone Coordinated transcriptional regulation of Hspa1a gene by multiple transcription factors: crucial roles for HSF-1 Plasma levels of Hsp70 and anti- Hsp70 antibody predict risk of acute coronary syndrome Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology Heat shock proteins in breast cancer progression- a suitable case for treatment? |
| cord-306904-8iteddug | Reconstituted human myosin light chain phosphatase reveals distinct roles of two inhibitory phosphorylation sites of the regulatory subunit, MYPT1 Structural and functional analysis of the GerD spore germination protein of Bacillus species Spores of Bacillus subtilis: their resistance to and killing by radiation, heat and chemicals Germination of spores of Bacillales and Clostridiales species: mechanisms and proteins involved Spore germination How do spores germinate? |
| cord-306904-8iteddug | The deletion of exon 3 in the cardiac ryanodine receptor is rescued by beta strand switching ATPinduced dimerization of the FF epsilon subunit from Bacillus PS3: a hydrogen exchange- mass spectrometry study Crystal structure of the epsilon subunit of the proton- translocating ATP synthase from Escherichia coli Phosphorylation of the cyclin CaPcl5 modulates both cyclin stability and specific recognition of the substrate Principles of CDK regulation Cyclin specificity: how many wheels do you need on a unicycle? |
| cord-279406-wwdqh9qs | 2020, 8, 409 Exosomes and non- coding RNA, the healers of the heart? |
| cord-279406-wwdqh9qs | How are we going to discover new cancer biomarkers? |
| cord-279406-wwdqh9qs | The pathway through LC- MS method development: In- house or ready- to- use kit- based methods? |
| cord-279406-wwdqh9qs | The resurgence of controversy Milk A1 ß- casein and health related outcomes in humans: A systematic review biological properties and other potential effects on human health of ß- casomorphin 7: Current knowledge and concerns A method for identifying discriminative isoform- specific peptides for clinical proteomics application An isoform of AIF1 involved in breast cancer PTEN proteoforms in biology and disease How many human proteoforms are there? |
| cord-279406-wwdqh9qs | What is functional and what is junk? |
| cord-279406-wwdqh9qs | Where did it come from, what is it, and where is it going? |
| cord-330312-1pjolkql | how big? |
| cord-018834-4ligp4ak | -serious adverse events reported worldwide in 1998- 2000 Albumin administration in the acutely ill: what is new and where next? |
| cord-018834-4ligp4ak | : how should you do it and what do the results mean? |
| cord-018834-4ligp4ak | : systematic review of randomised controlled trials Beautiful small: misleading large randomized controlled trials? |
| cord-018834-4ligp4ak | Albumin competitively inhibits glycation of less abundant proteins Impairment of serum albumin antioxidant properties in obstructive sleep apnoea syndrome Review article: albumin as a drug-- biological effects of albumin unrelated to oncotic pressure Serum albumin level as a risk factor for mortality in burn patients Risk factors and prognosis of hypoalbuminemia in surgical septic patients Hypoalbuminemia in acute illness: is there a rationale for intervention? |
| cord-018834-4ligp4ak | Albumin treatment reduces neurological defi cit and protects blood- brain barrier integrity after acute intracortical hematoma in the rat Serum albumin is a specifi c inhibitor of apoptosis in human endothelial cells Early albumin infusion improves global and local hemodynamics and reduces infl ammatory response in hemorrhagic shock Albumin resuscitation for traumatic brain injury: is intracranial hypertension the cause of increased mortality? |
| cord-018834-4ligp4ak | Albumin- beyond fl uid replacement in cardiopulmonary bypass surgery: why, how, and when? |
| cord-018834-4ligp4ak | Post- operative hypoalbuminaemia and procalcitonin elevation for prediction of outcome in cardiopulmonary bypass surgery Albumin supplementation as a therapeutic strategy in cardiac surgery: useful tool or expensive hobby? |
| cord-018834-4ligp4ak | Saline or albumin for fl uid resuscitation in patients with traumatic brain injury Fluid therapy and the use of albumin in the treatment of severe traumatic brain injury Fluid resuscitation in patients with traumatic brain injury: what is a safe approach? |
| cord-018834-4ligp4ak | biochemical properties and therapeutic potential S- nitroso- albumin carries a thiol- labile pool of nitric oxide, which causes venodilation in the rat Nitric oxide and peroxynitrite in health and disease Administration of albumin to patients with sepsis syndrome: a possible benefi cial role in plasma thiol repletion Albumin infl uences total plasma antioxidant capacity favorably in patients with acute lung injury Albumin-an important extracellular antioxidant? |
| cord-317900-05y9re12 | By theorizing uncertainty from the margins, he asks:"What more can we learn from alternative( including non- Western) cultures of uncertainty that construct the world in different ways, through different histories, social imaginaries, traditions of thinking, and everyday practices?" |
| cord-317900-05y9re12 | No Fly Zone? |
| cord-307046-ko3bdvo0 | -Where do you draw the line? |
| cord-307046-ko3bdvo0 | Does this number reflect the true diversity of viruses circulating in the vast territory of northern Eurasia? |
| cord-307046-ko3bdvo0 | alongside viruses for which we have a viable isolate? |
| cord-312434-yx24golq | : what can they teach us about the severe acute respiratory syndrome? |
| cord-312434-yx24golq | and now the 2019-novel CoV: have we investigated enough about coronaviruses? |
| cord-312434-yx24golq | what lessons have we learned? |
| cord-006127-rl7rur2j | A: Animal? |
| cord-006127-rl7rur2j | DG Enterprise Consultation Paper Proposal for a harmonised regulatory framework on human tissue engineered products Amended proposal for a European and Council Directive on setting standards of quality and safety for the donation, procurement, testing, processing, storage, and distribution of human tissues and cells Human tissue engineered products-drugs or devices? |
| cord-006127-rl7rur2j | Including? |
| cord-006127-rl7rur2j | That is, what are its limits? |
| cord-006127-rl7rur2j | What about the use of animal ory? |
| cord-006127-rl7rur2j | What is and is not XT? |
| cord-006127-rl7rur2j | Why has critique run out of steam? |
| cord-006127-rl7rur2j | expectations and the shaping of pharmacogenetics Claims and disclaimers: whose expertise counts? |
| cord-006127-rl7rur2j | such that they have a precise understanding of their regulatory object? |
| cord-006127-rl7rur2j | y[XT regulators in the UK] are very concerned with our groups using mouse fibroblasts, but when I ask them'are n't you concerned about bovine material?', they say that's not part of our remit because the cells are not alive. |
| cord-021113-e4ya7llm | But what about moral or nonmoral actions that are observed? |
| cord-021113-e4ya7llm | Does this mean that God's observation of us would imply that our basic autonomy- and hence our essential nature as persons- is constantly and unjustly violated? |
| cord-021113-e4ya7llm | So how then can the account of privacy invasion justification we have defended be relevant to constitutional accounts of privacy? |
| cord-021113-e4ya7llm | The coherence of theism Is there a god? |
| cord-021113-e4ya7llm | The effectiveness of such an extensive quarantine, however, has since been strongly questioned Privacy and the right to privacy Just looking: Voyeurism and the grounds of privacy Privacy, morality, and the law Philosophical dimensions of privacy: An anthology Privacy, intimacy, and personhood Severe acute respiratory syndrome: Did quarantine help? |
| cord-021113-e4ya7llm | The teachings of maimonides Privacy and control Privacy and perfect voyeurism God and privacy Secrecy, dignity or autonomy? |
| cord-021113-e4ya7llm | What then would morally allow for God's total observation? |
| cord-021113-e4ya7llm | and she does not want to be observed? |
| cord-331584-z43ifmr3 | 367pp Are we ready for pandemic influenza H5N1? |
| cord-307803-rlvk6bcx | How old are the major human pathogens? |
| cord-307803-rlvk6bcx | What are pathogens, and what have they done to and for us? |
| cord-307803-rlvk6bcx | What is the host range of pathogens? |
| cord-307803-rlvk6bcx | Where are the resistance- conferring genes in the human genome? |
| cord-315164-nidgnvvi | A Review of the Evidence Les adénovirus non- humains: Un risque zoonotique? |
| cord-315164-nidgnvvi | Neutralizing antibodies against 33 human adenoviruses in normal children in Rome Are adenoviruses zoonotic? |
| cord-315164-nidgnvvi | nonhuman primate or bat adenoviruses pose a risk for human health? |
| cord-335302-6wsx0jby | How many more might still be undetected? |
| cord-317501-yblzopc3 | Is Mycobacterium tuberculosis a closer relative to Gram- positive or Gram- negative bacterial pathogens? |
| cord-317501-yblzopc3 | The production of a genus- specific recombinant antibody( scFv) using a recombinant potyvirus protease Identification of a putative Crf splice variant and generation of recombinant antibodies for the specific detection of Aspergillus fumigatus Construction of human antibody gene libraries and selection of antibodies by phage display Highthroughput screening of single- chain antibodies using multiplexed flow cytometry Generating recombinant antibodies to the complete human proteome High level transient production of recombinant antibodies and antibody fusion proteins in HEK293 cells Recombinant human monoclonal antibodies to Ebola virus Making antibodies by phage display technology Which are the antibodies to watch in 2013? |
| cord-317501-yblzopc3 | The therapeutic monoclonal antibody market Highaffinity, human antibody- like antibody fragment( singlechain variable fragment) neutralizing the lethal factor( LF) of Bacillus anthracis by inhibiting protective antigen- LF complex formation Tumor necrosis factor alpha drugs in rheumatoid arthritis: systematic review and metaanalysis of efficacy and safety Anti- epidermal growth factor receptor monotherapy in the treatment of metastatic colorectal cancer: where are we today? |
| cord-268378-tcuv255v | But how can that group be certain that the information will not be used against them, by insurance companies, for example? |
| cord-268378-tcuv255v | On the other hand, if beneficial information is gleaned from one group, how is that benefit made available to other groups who were not studied? |
| cord-268378-tcuv255v | So what does understanding our evolutionary history add to our ability to improve human health? |
| cord-268378-tcuv255v | What was the link between removing worms and developing allergies? |
| cord-268378-tcuv255v | When so much data, including genetic information, are being gathered on so many people, how can a participating individual's privacy be protected while simultaneously making the information as widely available as possible( NHGRI 2007)? |
| cord-268378-tcuv255v | Why has n't natural selection made it better? |
| cord-268378-tcuv255v | Why? |
| cord-321835-qn33sx8x | Pyramidal and extrapyramidal involvement in experimental infection of cynomolgus monkeys with enterovirus 71 Enterovirus 71 infection and vaccines Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture Outbreak of febrile respiratory illness caused by adenovirus at a south Korean military training facility: clinical and radiological characteristics of adenovirus pneumonia Adenovirus vaccines Human adenovirus type 7 outbreak in police training center Dramatic decline of respiratory illness among US military recruits after the renewed use of adenovirus vaccines Acute respiratory disease associated with adenovirus serotype 14-four states Severe pneumonia due to adenovirus serotype 14: a new respiratory threat? |
| cord-321835-qn33sx8x | Types of Influenza Viruses Influenza A(H3N2) virus in swine at agricultural fairs and transmission to humans Are people living near modern swine production facilities at increased risk of influenza virus infection? |
| cord-337464-otwps68u | And Segment Forecasts A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody- secreting hybrid cell lines A better cell line for making hybridomas secreting specific antibodies Human monoclonal antibodies: the emperor's new clothes? |
| cord-314372-knhkdlq7 | Correlating low- similarity peptide sequences and allergenic epitopes Non- redundant peptidomes from DAPs: towards''the vaccine''? |
| cord-314372-knhkdlq7 | How many human proteins harbor viral peptide modules? |
| cord-314372-knhkdlq7 | what is the quantitative dimension of shortpeptide sequence sharing between viruses and human proteomes? |
| cord-308201-lavcsqov | A reconsideration of Koch's postulates The Environment and Disease: Association or Causation? |
| cord-308201-lavcsqov | New respiratory viral infections Emerging respiratory agents: New viruses for old diseases? |
| cord-308201-lavcsqov | What's new with respiratory viruses? |
| cord-308201-lavcsqov | authors: Desforges, Marc; Le Coupanec, Alain; Dubeau, Philippe; Bourgouin, Andréanne; Lajoie, Louise; Dubé, Mathieu; Talbot, Pierre J. title: Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? |
| cord-312438-zr9zx7pv | Does the human placenta express the canonical cell entry mediators for SARS- CoV-2? |
| cord-312438-zr9zx7pv | How can pathogens cross the SCT barrier and the VCT to infect the villous stroma? |
| cord-312438-zr9zx7pv | What is trophoblast? |
| cord-312438-zr9zx7pv | how do different pathogens escape or modulate the maternal- fetal host innate immune barrier( ii) why do some pathogens lead to congenital infection but not others? |
| cord-340971-e42g37la | Why? |
| cord-282610-zim7nond | Archaea are interactive components of complex microbiomes Measuring the archaeome: detection and quantification of archaea signatures in the human body Uncovering Earth's virome Bacteriophage transcytosis provides a mechanism to cross epithelial cell layers Does the microbiome and virome contribute to myalgic encephalomyelitis/ chronic fatigue syndrome? |
| cord-282610-zim7nond | Bacteria- tohuman protein networks reveal origins of endogenous DNA damage Extracellular vesicles and viruses: Are they close relatives? |
| cord-282610-zim7nond | IMG/ VR: a database of cultured and uncultured DNA Viruses and retroviruses IMG/ VR Database Triples in Size Persistent elevated expression of cytokine transcripts in ganglia latently infected with herpes simplex virus in the absence of ganglionic replication or reactivation Function and functional redundancy in microbial systems Functional redundancy of soil microbiota-does more always mean better? |
| cord-282610-zim7nond | Stealth Pathogens Parallels between post- polio fatigue and chronic fatigue syndrome: a common pathophysiology? |
| cord-282610-zim7nond | The Jarisch- Herxheimer reaction in syphilis: could molecular typing help to understand it better? |
| cord-282610-zim7nond | The human microbiome project Does blood of healthy subjects contain bacterial ribosomal DNA? |
| cord-030279-pv770doe | Accidents involving dangerous pathogens such as the causative agents of anthrax and bird flu were reported Biosafety in the Balance'Anthrax? |
| cord-030279-pv770doe | Are we sufficiently resilient to cope with the emotional distress, anxiety, shame, stigma and guilt that the awareness of severe medical conditions that we or our closed ones are suffering or likely to develop? |
| cord-030279-pv770doe | Extending Responsible Research and Innovation in Synthetic Biology to New Actors, Research Report for the Wellcome Trust Project'Building Sustainable Capacity in Dual Use Bioethics Secret Project Manufactured Mock Anthrax', The Washington Times Biological Weapons and America's Secret War Global Governance and the Twenty- First Century Technology Converging technologies for Improving Human Performance: Nanotechnology, Biotechnology, Information technology and Cognitive Science Report of the WHO Informal Consultation on Dual Use Research of Concern Biological Threat Assessment: Is the Cure Worse than the Disease? |
| cord-030279-pv770doe | How to account for this discrepancy? |
| cord-030279-pv770doe | Nature News Anthrax letters'attack and the controversy of the US biodefence programme see Jeanne Guillemin Army Suspends Germ Research at Maryland Lab Back to Bioweapons? |
| cord-030279-pv770doe | On the framing of risk in biotechnology, see Geert van Calster,'Risk Regulation, EU Law and Emerging Technologies: Smother or Smooth? |
| cord-030279-pv770doe | Panacea or Pandora's Box?', News Release On the security implications of synthetic biology, see International Council for the Life Sciences Synthetic Biology and Biosecurity Awareness in Europe |
| cord-030279-pv770doe | The Achilles'Helix From Eugenics to Patents Three- Person"Embryos to Combat Genetic Disease', The Guardian Innovative Genetic Treatment to Prevent Mitochondrial Disease, Press Release Three- Parent Embryos for Mitochondrial Disease? |
| cord-030279-pv770doe | Use of Gas against Terrorists during the Moscow Theatre Siege Was Justified, but the Rescue Operation afterwards Was Poorly Planned and Implemented Spasenie zalozhnikov ili unichtozhenie terroristov?', Novaya Gazeta |
| cord-331288-elnwn7l5 | ( Pan troglodytes verus) from Ivory Coast: Evidence for a new STLV-1 group? |
| cord-331288-elnwn7l5 | Why do chimpanzees die in the forest? |
| cord-324295-9c1zxjng | The next big threat to global health? |
| cord-324295-9c1zxjng | What is the potential impact of the Amazon wildfires on vector- borne and zoonotic emerging diseases? |
| cord-308857-otsrexqu | A major question remains open to date,"how can the symptoms of COVID-19 be detected in their early stages? |
| cord-308857-otsrexqu | A more specific question is whether ultra- violet( UV) light can kill coronavirus? |
| cord-308857-otsrexqu | COVID-19: A new digital dawn? |
| cord-308857-otsrexqu | Will 10 million people die a year due to antimicrobial resistance by 2050? |
| cord-308857-otsrexqu | [ 104] asked"Will 10 million people die a year due to AMR by 2050? |
| cord-338468-c0jv3i1t | The trinity of COVID-19: Immunity, inflammation and intervention On the molecular determinants of the SARS- CoV-2 attack Are the universes of antibodies and antigens symmetrical? |
| cord-274756-nnm1n09a | Innate lymphoid cells- how did we miss them? |
| cord-274756-nnm1n09a | The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: Implications for cancer therapy Natural killer cells in cancer immunotherapy Immunotherapy in acute myeloid leukemia and myelodysplastic syndromes: the dawn of a new era? |
| cord-274756-nnm1n09a | What are the mechanisms that lead to a break in tolerance? |
| cord-274756-nnm1n09a | Will immunogenicity limit the use, efficacy, and future development of therapeutic monoclonal antibodies? |
| cord-274756-nnm1n09a | causes and conversion CTLA-4/ CD80 pathway regulates T cell infiltration into pancreatic cancer Molecular interactions of antibody drugs targeting PD-1, PD- L1, and CTLA-4 in immuno- oncology Immunosenescence and its hallmarks: how to oppose aging strategically? |
| cord-274756-nnm1n09a | how"lytic"must they be for therapeutic efficacy? |
| cord-274756-nnm1n09a | plasticity in human autoimmune arthritis is driven by the inflammatory environment Harnessing the plasticity of CD4+ T cells to treat immune- mediated disease Immunological memory: what's in a name? |
| cord-006230-xta38e7j | 2´-deoxy- cAMP in human cell lines: Another second messenger? |
| cord-006230-xta38e7j | > Ser Extra- adrenal glucocorticoid synthesis in the intestinal epithelium: more than a drop in the ocean? |
| cord-006230-xta38e7j | Converging of the classical mitochondria- related pathway in Parkinson and nuclear DNA- repair signaling? |
| cord-006230-xta38e7j | Detoxification by conjugation of glutathione? |
| cord-006230-xta38e7j | Is formaldehyde a good example for a"genotoxic carcinogen"with a threshold mode of action? |
| cord-006230-xta38e7j | The transcriptome analyses of human cells showed that additionally to the 30.000 protein coding sequences the human DNA codes for much more( 450.000?) |
| cord-006230-xta38e7j | possible link between diabetes and cancer? |
| cord-005147-mvoq9vln | -how do we manage the extreme costs of these products, especially in light of the many unsolved issues with respect to effectiveness? |
| cord-005147-mvoq9vln | -what is the influence of antibody generation on clinical effectiveness? |
| cord-005147-mvoq9vln | -what is the natural history and"point of no return"for subgroups of patients within one LSD's? |
| cord-005147-mvoq9vln | > G;p.?) |
| cord-005147-mvoq9vln | And then: what is early? |
| cord-005147-mvoq9vln | Congenital myopathies and congenital muscular dystrophies: Will genetic testing replace muscle biopsy in the near future? |
| cord-005147-mvoq9vln | Disproportioned short stature and multiple anomalies in a patient with a homozygous PIK3C2A mutation-a new ciliopathy? |
| cord-005147-mvoq9vln | Inherited DNA repair mutations: are they modifiers of BRCA1 and BRCA2 penetrance and age at onset of hereditary breast and ovarian cancer? |
| cord-005147-mvoq9vln | Many unresolved questions exist at this stage, including the following:-what is the natural history and"point of no return"for the different LSD's? |
| cord-005147-mvoq9vln | What is the functional role of these ectopically expressed olfactory receptors? |
| cord-031482-atltc10d | : Is there a connection? |
| cord-031482-atltc10d | An incident in DeLand, Fla. in 2018, when a woman being held captive at gunpoint by her abusive boyfriend was able to alert veterinary staff who in turn called the police( Robbins, 2018), brought to national attention what was just beginning to be discussed in professional journals: how should veterinarians and their staffs, the majority of whom now are women( Kelly, 2017), respond to suspected domestic violence in their clientele? |
| cord-031482-atltc10d | Are there animals at home? |
| cord-031482-atltc10d | Are you worried about their welfare? |
| cord-031482-atltc10d | How are they cared for? |
| cord-031482-atltc10d | Social Work in Health Care Arrest and prosecution of animal sex abuse( bestiality) offenders in the United States Cute and cuddly and a whole lot more? |
| cord-031482-atltc10d | The Link between interpersonal violence and animal abuse A study on the relationship of child abuse and pet abuse Animal cruelty and bullying: Behavioral markers of delinquency risk or causal antecedents of delinquent behavior? |
| cord-031482-atltc10d | The pet connection: Pets as a conduit for social capital? |
| cord-031482-atltc10d | They burn brightly, but only for a short time": The role of social workers in companion animal grief and loss Is counseling going to the dogs? |
| cord-031482-atltc10d | When domestic violence arrives at the clinic door: How veterinary staff can respond to abused clients and patients The community context of animal and human maltreatment: Is there a relationship between animal maltreatment and human maltreatment: Does neighborhood context matter? |
| cord-332379-340wczmq | How do general practitioners manage eye disease in the community? |
| cord-332379-340wczmq | Human adenovirus species D types 15, 29, 56, and 69 Association of adenovirus with the microtubule organizing center Endocytosis via caveolae: Alternative pathway with distinct cellular compartments to avoid lysosomal degradation? |
| cord-005068-3ddb38de | Ethics and public health: forging a strong relationship Challenging a well established consent norm?: |
| cord-005068-3ddb38de | Genomic databases as global public goods? |
| cord-005068-3ddb38de | Human genetic research: emerging trends in ethics Human genomic databases: a global public good? |
| cord-005068-3ddb38de | In: Last JM( ed) Maxcy- Rosenau public health and preventive medicine, 12th edn Personalized medicine: elusive dream or imminent reality? |
| cord-005068-3ddb38de | The meaning of''people''in the African Charter on Human and Peoples'Rights Population genetics and benefit sharing Of biotechnology and man Biobanking: international norms Of genomics and public health: building a global public good? |
| cord-005068-3ddb38de | What will it take to reap the clinical benefits of pharmacogenomics? |
| cord-005068-3ddb38de | Will genomics widen or help heal the schism between medicine and public health? |
| cord-005068-3ddb38de | Will international human rights subsume medical ethics? |
| cord-005068-3ddb38de | between biobanks: the case for harmonisation of guidelines and governance Ethics and privacy issues for systems biology application in predictive and personalized medicine Public health ethics: mapping the terrain Germline pharmacogenetics of tamoxifen response: have we learned enough? |
| cord-005068-3ddb38de | cord-005068- 3ddb38de authors: Meslin, Eric M.; Garba, Ibrahim title: Biobanking and public health: is a human rights approach the tie that binds? |
| cord-005068-3ddb38de | the ethical gravity of informed consent DNA synthesis and biological security Extending the reach of public health genomics: what should be the agenda for public health in an era of genome- based and''personalized''medicine? |
| cord-340629-1fle5fpz | Novel human astroviruses: Novel human diseases? |
| cord-016499-5iqpl23p | Antimicrobials for acute otitis media? |
| cord-016499-5iqpl23p | Do rhinoviruses reduce the probability of viral codetection during acute respiratory tract infections? |
| cord-016499-5iqpl23p | Human major group rhinoviruses downmodulate the accessory function of monocytes by inducing IL-10 Rhinovirus- induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness Nasal- secretion leukocyte populations determined by fl ow cytometry during acute rhinovirus infection Expression of intercellular adhesion molecule-1( ICAM-1) in nasal epithelial cells of atopic subjects: a mechanism for increased rhinovirus infection? |
| cord-016499-5iqpl23p | Infl uenza vaccination in the prevention of acute otitis media in children Effi cacy of a pneumococcal conjugate vaccine against acute otitis media Rhinovirus in acute otitis media Temporal relationships between colds, upper respiratory viruses detected by polymerase chain reaction, and otitis media in young children followed through a typical cold season Presence of viral nucleic acids in the middle ear: acute otitis media pathogen or bystander? |
| cord-016499-5iqpl23p | Is acute otitis media a treatable disease? |
| cord-016499-5iqpl23p | So, what do cohort studies, supported by comprehensive PCR- based testing, tell us about asymptomatic virus infections? |
| cord-016499-5iqpl23p | The cold case: Are rhinoviruses perfectly adapted pathogens? |
| cord-016499-5iqpl23p | The common cold: control? |
| cord-016499-5iqpl23p | The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitis Rhinovirus infections of children in hospital; isolation of three possibly new rhinovirus serotypes Do rhinoviruses reduce the probability of viral co- detection during acute respiratory tract infections? |
| cord-016499-5iqpl23p | This feature raises an issue: did the use of older subjects in many common cold studies underplay the pathogenic potential of the HRVs because protective or partially cross- protective antibodies moderated the impact of infection? |
| cord-016499-5iqpl23p | human rhinovirus type 17 Antigenic variation of rhinovirus type 22 Isolation of rhinovirus intertypes related to either rhinoviruses 12 and 78 or 36 and 58 Is a rhinovirus vaccine possible? |
| cord-337646-gkcm6ds0 | Environ Pollut Seasonality of respiratory viral infections Environmental engineers and scientists have important roles to play in stemming outbreaks and pandemics caused by enveloped viruses Environmental perspective of COVID-19 Respiratory virus shedding in exhaled breath and efficacy of face masks Covid-19 airborne transmission and its prevention: waiting for evidence or applying the precautionary principle? |
| cord-337646-gkcm6ds0 | The SARS, MERS and novel coronavirus( COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? |
| cord-337646-gkcm6ds0 | state of the knowledge and research needs Water, sanitation, hygiene, and waste management for the COVID-19 virus: interim guidance Can atmospheric pollution be considered a co- factor in extremely high level of SARS- CoV-2 lethality in Northern Italy? |
| cord-312461-5qzpo6l1 | At what stage of illness are rescue oxygenation devices warranted? |
| cord-312461-5qzpo6l1 | For example, what adjunctive therapies are useful? |
| cord-312461-5qzpo6l1 | The pathogenic potential of a microbe Exserohilum rostratum fungal meningitis associated with methylprednisolone injections Microbial threat lists: obstacles in the quest for biosecurity? |
| cord-312461-5qzpo6l1 | What coinfections may be present? |
| cord-319933-yp9ofhi8 | * Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome SARS vaccines: where are we? |
| cord-319933-yp9ofhi8 | An unusual hantavirus outbreak in southern Argentina: person- to- person transmission? |
| cord-319933-yp9ofhi8 | Efficacy assessment of a cell- mediated immunity HIV-1 vaccine( the step study): a double- blind, randomised, placebo- controlled, test- of- concept trial Human papillomavirus in cervical cancer Human papillomavirus research: do we still need animal models? |
| cord-319933-yp9ofhi8 | Phenotypic changes in Langerhans'cells after infection with arboviruses: a role in the immune response to epidermally acquired viral infection? |
| cord-349177-8h25qj9y | A chimpanzee genome project is a biomedical imperative Multiple changes in sialic acid biology during human evolution Since there are PAMPs and DAMPs, there must be SAMPs? |
| cord-339386-sxyeuiw1 | The adaptation of two human coronavirus strains( OC38 and OC43) to growth in cell monolayers Detection of the new human coronavirus HKU1: a report of 6 cases Culturing the unculturable: human coronavirus HKU1 infects, replicates, and produces progeny virions in human ciliated airway epithelial cell cultures Pleomorphic virus- like particles in human faeces Chronic enterocyte infection with coronavirus: one possible cause of the syndrome of tropical sprue? |
| cord-296863-xu0h92ac | Can we develop universal principles in bioethics? |
| cord-296863-xu0h92ac | Did anything change? |
| cord-296863-xu0h92ac | If a person's destiny is to become social, cultural, and moral clones, why should genetic cloning not be permitted? |
| cord-296863-xu0h92ac | In my opinion, the question would be most clear if raised the other way round: has a person the right to buy( or to rent) parts of the body of another human being? |
| cord-296863-xu0h92ac | The moral question"Is there a freedom to sell his own body?" |
| cord-296863-xu0h92ac | The questions are now: what security, and for whom? |
| cord-296863-xu0h92ac | Very few raised two general questions: what else can we expect for world health from potential climate change, and what should we do about present and future risks? |
| cord-296863-xu0h92ac | What is security? |
| cord-329149-1giy1fow | A secreted protein microarray platform for extracellular protein interaction discovery Viral mimicry of cytokines, chemokines and their receptors Pathogen- derived immunomodulatory molecules: future immunotherapeutics? |
| cord-329149-1giy1fow | How do pathogens drive the evolution of paired receptors? |
| cord-329149-1giy1fow | How many drug targets are there? |
| cord-329149-1giy1fow | What have RNAi screens taught us about viral- host interactions? |
| cord-318407-uy0f7f2o | How must academic veterinary medicine adapt to prepare veterinarians to respond to these new needs? |
| cord-318407-uy0f7f2o | How will these changes alter the needs of society? |
| cord-318407-uy0f7f2o | Misleading media reporting? |
| cord-318407-uy0f7f2o | The general epidemiologist: is there a place in today's epidemiology? |
| cord-318407-uy0f7f2o | or do we? |
| cord-354592-vqws942c | The baboon model( Papio hamadryas) of fetal loss: maternal weight, age, reproductive history and pregnancy outcome Pro- labour myometrial gene expression: are preterm labour and term labour the same? |
| cord-335567-ssnvr6nj | Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis Prevalence and clinical symptoms of human metapneumovirus infection in hospitalized patients Clinical impact and diagnosis of human metapneumovirus infection Emerging respiratory agents: New viruses for old diseases? |
| cord-335567-ssnvr6nj | Passenger or pathogen in acute respiratory tract infections? |
| cord-253111-n5ywei4t | An influenza epicentre? |
| cord-253111-n5ywei4t | Can we say that birdwatchers take the perspectives of threatened wild birds as virologists take the perspective of poultry infected with flu viruses? |
| cord-253111-n5ywei4t | Cultural Anthropology website Pourquoi la fiction? |
| cord-253111-n5ywei4t | He asks: how do participants come to believe in a series of speeches and actions-the novice's death and the goat's consent to sacrifice-that are obviously false? |
| cord-253111-n5ywei4t | How do humans in charge of the protection of animals cope with the oppositions we have seen in reverse scenarios of pandemics? |
| cord-253111-n5ywei4t | How does preparedness transform relations between humans and birds? |
| cord-253111-n5ywei4t | How does the description of animals as victims of disasters transform them into actors of simulations( Keck& Ticktin 2015)? |
| cord-253111-n5ywei4t | The main question, according to Mr Wong, was:'If there are 200 casualties in one hospital, which resources do they need?' |
| cord-253111-n5ywei4t | What does it mean for a simulation to be realistic? |
| cord-253111-n5ywei4t | What does it mean to include birds, and more generally animals, in exercises simulating coming disasters? |
| cord-253111-n5ywei4t | Who thought of the blood- stained old woman with the birdcage? |
| cord-031907-ilhr3iu5 | Extracellular Vesicle- based liquid biopsy in Acute Myeloid Leukaemia: a reliable source of residual disease biomarkers? |
| cord-336157-aqc9zrrm | Does this mean that if we develop vaccines and antiviral drugs to prevent or treat humans against infection by pathogenic arboviruses we will resolve the challenges associated with emerging arboviruses? |
| cord-336157-aqc9zrrm | Rapid determination of viral RNA sequences in mosquitoes collected in the field Detection and monitoring of mosquito flaviviruses in Spain between Surveillance of mosquito- borne viruses in Alberta using reverse transcription polymerase chain reaction with generic primers Detection of novel insect flavivirus sequences integrated in Aedes albopictus( Diptera: Culicidae) in Northern Italy Surveillance of arboviruses in Spanish wetlands: detection of new flavi- and phleboviruses Arboviral survey of mosquitoes in two northern Italian regions in Insect- specific flaviviruses from Culex mosquitoes in Colorado, with evidence of vertical transmission RNAi targeting of West Nile virus in mosquito midguts promotes virus diversification Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come? |
| cord-336157-aqc9zrrm | Therefore, should we attempt global eradication of arthropods? |
| cord-336157-aqc9zrrm | What are the major objectives that need to be addressed if we are to win the war against these versatile viruses that appear to have an infinitesimal variety Factors, strategies and challenges for arbovirus control G Liang et al 3 of strategies to confuse and disorganize our ability to bring them under control? |
| cord-022544-7jn4ns6x | ( Ig)A plasma cell accumulation in the lactating mammary gland and IgA antibody transfer to the neonate Does breast milk protect against septicaemia in the newborn? |
| cord-022544-7jn4ns6x | Do infants need nucleotide supplemented formula for optimal nutrition? |
| cord-022544-7jn4ns6x | Does breast- feeding really matter? |
| cord-022544-7jn4ns6x | Effects of microwave radiation on anti- infective factors in human Milk Breastfeeding and hospitilization for diarrheal and respiratory infection in the United Kingdom Millenium Cohort Study Breast- feeding and infant illness: A dose- response relationship? |
| cord-022544-7jn4ns6x | How good is the evidence? |
| cord-022544-7jn4ns6x | How many child deaths can we prevent this year? |
| cord-022544-7jn4ns6x | In vitro studies on the T- lymphocyte population of human milk Quantitative determination of immunoglobulins, lysozyme, and certain electrolytes in breast milk during the entire period of lactation, during a 24-hour period, and in milk from the individual mammary gland Probiotic bacteria down- regulate the milk- induced inflammatory response in milk- hypersensitive subjects but have an immunostimulatory effect in healthy subjects Factors influencing the composition of the intestinal microbiota in early infancy Bacterial imprinting of the neonatal immune System: lessons from maternal cells? |
| cord-022544-7jn4ns6x | Is adequate information available to justify using nucleotides in infant formula in higher amounts and different compositions than are currently used? |
| cord-022544-7jn4ns6x | The antimicrobial activity of human colostral antibody in the newborn Enterobacteriaceae and neonatal necrotizing enterocolitis Gdalevich M: Does breastfeeding protect against allergic rhinitis during childhood? |
| cord-022544-7jn4ns6x | What are the proven mechanisms of action of these proposed benefits? |
| cord-022544-7jn4ns6x | What form and concentration of nucleotides are necessary to effect these benefits? |
| cord-350286-n7ylgqfu | Do Viral Proteins Possess Unique Features? |
| cord-350286-n7ylgqfu | Intrinsic disorderedness and functionality of HIF-1α along with its interacting proteins Why are"natively unfolded"proteins unstructured under physiologic conditions? |
| cord-316792-89f8g0m8 | Do the potential benefits outweigh the risks? |
| cord-316792-89f8g0m8 | How ow? |
| cord-316792-89f8g0m8 | The emergence of macrocyclic lactone resistance in the canine heartworm, Dirofilaria immitis Multiple drug resistance in the canine hookworm Ancylostoma caninum: an emerging threat? |
| cord-316792-89f8g0m8 | The venom optimization hypothesis revisited Combinatorial peptide libraries in drug design: lessons from venomous cone snails Were arachnids the first to use combinatorial peptide libraries? |
| cord-316792-89f8g0m8 | crawling biochemists with diverse toxin pharmacopeias Entomo- venomics: the evolution, biology and biochemistry of insect venoms Pharmacology and biochemistry of spider venoms Venom composition and strategies in spiders: is everything possible? |
| cord-262868-wanbz1et | Are there other consequences for infection risk or resistance in humans? |
| cord-262868-wanbz1et | Do the traces of Neu5Gc found in normal humans indeed come from dietary sources? |
| cord-262868-wanbz1et | Does it matter that animal organs intended for xenotransplantation and certain biotechnology therapeutics produced in animal cells can be quite rich in Neu5Gc? |
| cord-262868-wanbz1et | For example, when did this mutation first occur, and when did it become fixed as a universal feature of human ancestors? |
| cord-262868-wanbz1et | If so, are there any pathological consequences to the human ingestion of Neu5Gc in foods of animal origin? |
| cord-262868-wanbz1et | Is the mechanism of Neu5Gc reexpression in tumors and fetuses simply an exaggeration of what happens in normal tissues? |
| cord-262868-wanbz1et | Not just old but old and cold? |
| cord-262868-wanbz1et | Or is there another biochemical pathway that becomes activated in these situations? |
| cord-262868-wanbz1et | What are the functional consequences for Varki] the intrinsic human sialic- acid receptors whose Neu5Gc preference has yet to be explored? |
| cord-262868-wanbz1et | When did this mutation occur in relation to the various steps in human evolution? |
| cord-262868-wanbz1et | Why did humans lose Neu5Gc production? |
| cord-262868-wanbz1et | not least, what are the consequences, if any, for the evolution and function of the human brain? |
| cord-323380-hm9wd817 | Can human schistosomiasis mansoni control be sustained in high- risk transmission foci in Egypt? |
| cord-323380-hm9wd817 | Gharbia Governorate Foci of Schistosoma mansoni in Assiut province in middle Egypt Is Schistosoma mansoni replacing Schistosoma haematobium in the Fayoum? |
| cord-323380-hm9wd817 | Isolation of the virus from animals Mosquito vectors of infectious diseases: Are they neglected health disaster in Egypt? |
| cord-323380-hm9wd817 | The mosquito borne West Nile virus infection: Is it threating to Egypt or a neglected endemic disease? |
| cord-323380-hm9wd817 | Will Egypt be the epicentre of the next influenza pandemic? |
| cord-017686-127xfkse | ( b) non- citizens have no recourse to rights( to education, health, justice)? |
| cord-017686-127xfkse | By whom? |
| cord-017686-127xfkse | How far? |
| cord-017686-127xfkse | It begs the questions: for whom? |
| cord-017686-127xfkse | Second, what are the consequences of human security provision to citizens of A or B by NSAs, notably when NSAs go bankrupt or depart? |
| cord-017686-127xfkse | The Responsibility to Respond Sovereignty and Power in a Networked World Order Democratic Waves? |
| cord-017686-127xfkse | This leads to two questions: first, if State A acts as a guarantor to the human security of citizens of A, the same holds for State B and citizens of B; but what happens to citizens of State A residing in State B, or vice versa? |
| cord-017686-127xfkse | Was heisst das? |
| cord-017686-127xfkse | What does domestic sovereignty mean if( a) a portion of the citizenry is excluded from, for instance, health care? |
| cord-017686-127xfkse | What is interdependence sovereignty if borders are porous or surveillance systems are technologically or politically incompatible? |
| cord-017686-127xfkse | What is the value of Westphalian sovereignty where a State can not control its territory? |
| cord-017686-127xfkse | What role does juridical sovereignty play when a State is only partially recognized by its peers? |
| cord-017686-127xfkse | Why Human Security? |
| cord-275796-4560i8cx | ( PD- L1) during HMPV infection leads to impairment of CD8? |
| cord-275796-4560i8cx | 441 impair CD8? |
| cord-275796-4560i8cx | However, if CD4? |
| cord-275796-4560i8cx | Studies done on mice models indicate that during HMPV primary infection, CD4? as well as CD8? |
| cord-275796-4560i8cx | Studies done on mice models indicate that during HMPV primary infection, CD4? as well as CD8? |
| cord-275796-4560i8cx | T cells are depleted, the infection is less severe and CD8? |
| cord-275796-4560i8cx | T cells through PD-1 PD-1 impairs secondary effector lung CD8? |
| cord-275796-4560i8cx | The development of live attenuated cold- adapted influenza virus vaccine for humans Perspective on the host response to human metapneumovirus infection: what can we learn from respiratory syncytial virus infections? |
| cord-275796-4560i8cx | and CD8? |
| cord-275796-4560i8cx | by CD4? |
| cord-339382-ii4xurmr | ( PCV2) vaccination of conventional pigs prevents viremia against PCV2 isolates of different genotypes and geographic origins Serologic response to porcine circovirus type 1( PCV1) in infants vaccinated with the human rotavirus vaccine, Rotarix ™: a retrospective laboratory analysis Chicken infectious anemia virus: an example of the ultimate host- parasite relationship Novel gyroviruses, including chicken anaemia virus, in clinical and chicken samples from South Africa Characterization of a novel gyrovirus in human stool and chicken meat Polyomaviruses and human cancer: molecular mechanisms underlying patterns of tumorigenesis Human exposure to bovine polyomavirus: a zoonosis? |
| cord-339382-ii4xurmr | A metagenomic assessment of viral contamination on fresh parsley plants irrigated with fecally tainted river water Adenovirus and norovirus contaminants in commercially distributed shellfish Les adénovirus non- humains- Un risque zoonotique? |
| cord-339382-ii4xurmr | Can plant virus infect human being? |
| cord-339382-ii4xurmr | teno sus virus species k2b from pigs in the United States and lack of association with post- weaning multisystemic wasting syndrome or mulberry heart disease Torque teno sus virus in pigs: an emerging pathogen? |
| cord-331255-t85yioyl | A qualitative meta- analysis reveals consistent effects of atrazine on freshwater fish and amphibians Early- life exposure to a herbicide has enduring effects on pathogen- induced mortality Community ecology as a framework for predicting contaminant effects Community responses to contaminants: using basic ecological principles to predict ecotoxicological effects How should environmental stress affect the population dynamics of disease? |
| cord-331255-t85yioyl | Host resistance and tolerance of parasitic gut worms depend on resource availability Why on earth? |
| cord-331255-t85yioyl | Nearly 400 million people are at higher risk of schistosomiasis because dams block the migration of snail- eating river prawns Drivers of wetland conversion: a global meta- analysis From discovery to eradication of schistosomiasis in Japan: 1847- 1996 Lessons of history? |
| cord-331255-t85yioyl | Spatial scale modulates the strength of ecological processes driving disease distributions Sacred cows and sympathetic squirrels: the importance of biological diversity to human health Biodiversity inhibits parasites: broad evidence for the dilution effect Human health impacts of ecosystem alteration Empirical evidence of the public health benefits of tropical forest conservation in Cambodia: a generalised linear mixed- effects model analysis Does forest loss increase human disease? |
| cord-331255-t85yioyl | The economy of inflammation: when is less more? |
| cord-331255-t85yioyl | Tropical forests were the primary sources of new agricultural land in the 1980s and 1990s Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study A research agenda for helminth diseases of humans: the problem of helminthiases Human health and pesticide use in sub- Saharan Africa Emerging infectious pathogens of wildlife Risk factors for human disease emergence Assessing the impact of the Green Revolution Global environmental impacts of agricultural expansion: the need for sustainable and efficient practices Assessing the direct and indirect effects of food provisioning and nutrient enrichment on wildlife infectious disease dynamics Trade- offs in evolutionary immunology: just what is the cost of immunity? |
| cord-302222-9ad0fw6z | An interesting question is: who will pay for vaccination of feedlot cattle? |
| cord-302222-9ad0fw6z | Is the economic benefit there for the meat industry, and will vaccination reduce the cost of other preventive measures and testing or will vaccine costs simply be on top of other costs? |
| cord-302222-9ad0fw6z | One health: the importance of companion animal vector- borne diseases Arthropod- borne infectious diseases of the dog and cat Zoonoses Control in dogs How to eradicate canine rabies: a perspective of historical efforts Mass vaccination campaign against rabies: are dogs correctly protected? |
| cord-302222-9ad0fw6z | Since ground beef only contributes about one- third of human infections, how could vaccines be used as a means of reducing other sources of food contamination? |
| cord-302222-9ad0fw6z | The use of veterinary vaccines for prevention and control of Rift Valley fever: memorandum from a WHO/ FAO meeting ZH501-VSVRI: Is it still the best choice for vaccination against Rift Valley fever in Egypt? |
| cord-302222-9ad0fw6z | Will government agencies concerned with human health subsidize the cost, without empirical demonstration of a human health benefit? |
| cord-302222-9ad0fw6z | understanding the dual- host lifestyle of Lyme disease spirochaetes The emergence of Lyme disease Vaccines against Lyme disease: what happened and what lessons can we learn? |
| cord-302222-9ad0fw6z | what happens on the ground? |
| cord-021375-lca26xum | ( Crawford 2007, 213) How do we live in harmony with the microbial world but still prevent infectious diseases from developing? |
| cord-021375-lca26xum | : On the Possibility of Life in Capitalist Ruins Human Endogenous Retroviruses( Hervs) and Autoimmune Rheumatic Disease: Is There a Link? |
| cord-021375-lca26xum | Alive? |
| cord-021375-lca26xum | As the human can not be thought without the virus, and attempts to alter or eliminate it( in)directly also affect the human, how might we think differently about urban spaces and public health if we consider the human and the virus not as opposed but as fundamentally interrelated? |
| cord-021375-lca26xum | Considering recent advances in gene sequencing in microbiology, through which a"vast diversity of microbial life in, on and around the human body"( Lorimer 2017, 544) has been identified as residing in complex relationality with one another, how befitting is it to fight infectious diseases by indiscriminately eliminating microbes through the use of antimicrobials and practicing urban hygiene as in the case of Hong Kong? |
| cord-021375-lca26xum | Creating the North American Landscape What Is a Pathogen? |
| cord-021375-lca26xum | How can a microbial approach to global health security protect life? |
| cord-021375-lca26xum | How can this emerging ontological and epistemological understanding of human life inform the governance of disease? |
| cord-021375-lca26xum | How do we move from a potentially destructive antimicrobial perspective such as is embodied in Hong Kong to a microbial perspective in which we take responsibility for our vital relation with the microbial world? |
| cord-021375-lca26xum | How then can human efforts be conceived to control pathogenic, while fostering benign, viral circulation? |
| cord-021375-lca26xum | Human Placental Morphogenesis Only Human? |
| cord-021375-lca26xum | What are the implications of this understanding of the human body as mostly microbial to the way we fight infectious diseases in global cities and elsewhere? |
| cord-021375-lca26xum | What happens when the enemy is not the virus or other microbes but us( Methot and Alizon 2014, 778)? |
| cord-006229-7yoilsho | But what would happen if the HFD was switched to normal pellet diet in these diabetic rats? |
| cord-006229-7yoilsho | Core or coating material? |
| cord-006229-7yoilsho | Increased GABA release in human neocortex at high intracellular sodium and low extracellular calcium-an anti- seizure mechanism?] |
| cord-006229-7yoilsho | Occasionally there are specific questions occurring on the ruminant xenobiotic metabolism: 1) are the observed metabolites ruminant specific and formed directly in the rumen? 2) are ruminants able to cleave plant specific metabolites like glycosides to the respective aglycon? |
| cord-006229-7yoilsho | Occasionally there are specific questions occurring on the ruminant xenobiotic metabolism: 1) are the observed metabolites ruminant specific and formed directly in the rumen? 2) are ruminants able to cleave plant specific metabolites like glycosides to the respective aglycon? |
| cord-006229-7yoilsho | The data point to a role of Rac1-regulated filamentous( nuclear?) |
| cord-006229-7yoilsho | The γH2AX Assay for Genotoxic and Nongenotoxic Agents: Comparison of H2AX Phosphorylation with Cell Death Response Perturbation of mitosis through inhibition of histone acetyltransferases: the key to ochratoxin a toxicity and carcinogenicity? |
| cord-006229-7yoilsho | Vitamin D metabolism-Involved in triazole fungicide toxicity? |
| cord-006229-7yoilsho | What dictates the uptake and translocation of nanoparticles in vitro? |
| cord-006229-7yoilsho | What would happen without this exception? |
| cord-346331-d0s028wl | ; Williams, Janet E.; Bode, Lars; Donovan, Sharon M.; Järvinen, Kirsi M.; Seppo, Antti E.; Raiten, Daniel J.; Meehan, Courtney L.; McGuire, Mark A.; McGuire, Michelle K. title: SARS‐CoV‐2 and human milk: What is the evidence? |
| cord-346331-d0s028wl | Born to Mothers With COVID-19 Pneumonia Postnatal transmission of aids- associated retrovirus from mother to infant SARS- CoV-2 and human milk: What is the evidence? |
| cord-346331-d0s028wl | The Lancet Cytomegalovirus infection of breast milk and transmission in infancy Perinatal transmission of COVID-19 associated SARS- CoV-2: Should we worry? |
| cord-331343-qzvwwca9 | 15 Let us go back to the plot: what do we know of the novel arenavirus found by Palacios and colleagues? |
| cord-331343-qzvwwca9 | 3, 22 Therefore, to what extent should we be worried by rodent infections in our transplant patients, and should we be screening donors for these emerging pathogens? |
| cord-331343-qzvwwca9 | Does a betaretrovirus infection trigger primary biliary cirrhosis? |
| cord-331343-qzvwwca9 | However, is it avoidable? |
| cord-331343-qzvwwca9 | Will the brute- force approach of high- throughput sequencing catch on for virus discovery? |
| cord-349168-ec5p9b2f | : should we reintroduce key predators in our ecosystem? |
| cord-349168-ec5p9b2f | Targeting microbiota: what do we know about it at present? |
| cord-349168-ec5p9b2f | The placenta harbors a unique microbiome Comparison of placenta samples with contamination controls does not provide evidence for a distinct placenta microbiota A critical assessment of the"sterile womb"and"in utero colonization"hypotheses: implications for research on the pioneer infant microbiome Preserving microbial diversity Early- life formation of the microbial and immunological environment of the human airways Ecological succession in the vaginal microbiota during pregnancy and birth Strain- level analysis of mother- to- child bacterial transmission during the first few months of life Can we save our body's ecosystem from extinction? |
| cord-297216-1b99hm1e | A Cultural History Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children Relating Urban Biodiversity to Human Health With the'Holobiont Does Soil Contribute to the Human Gut Microbiome? |
| cord-297216-1b99hm1e | A New Vision of Immunity: Homeostasis of the Superorganism Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System? |
| cord-297216-1b99hm1e | Can Big Data and Predictive Analytics Deliver Precision Public Health? |
| cord-297216-1b99hm1e | Globally Multidrug- Resistant Candida Auris:'New Kid on the Block'in Hospital- Associated Infections? |
| cord-297216-1b99hm1e | Humans Increasing Bacterial Evolvability? |
| cord-297216-1b99hm1e | If this is indeed true, then could microbes also be critical for mental health? |
| cord-297216-1b99hm1e | The Global Need for Effective Antibiotics: Challenges and Recent Advances Nonmedical Uses of Antibiotics: Time to Restrict Their Use? |
| cord-297216-1b99hm1e | The Imaginary of Precision Public Health Will Precision Medicine Lead to a Healthier Population? |
| cord-297216-1b99hm1e | What if, in addition to protection against allergies and asthma, bacteria were protecting us against mental health conditions such as schizophrenia, bipolar disease, and autism? |
| cord-341701-zropd3mo | An interactive web- based dashboard to track COVID-19 in real time How will country- based mitigation measures influence the course of the COVID-19 epidemic? |
| cord-341701-zropd3mo | Can MALDI- TOF mass spectrometry reasonably type bacteria? |
| cord-341701-zropd3mo | Database allows unpublished, preliminary or proprietary data( e.g., antibody, MS, cell biology and genetic studies CHESS: a new human gene catalog curated from thousands of large- scale RNA sequencing experiments reveals extensive transcriptional noise Dynamic visualization of multi- level molecular data: the Director package in R Can we predict protein from mRNA levels? |
| cord-341701-zropd3mo | The human protein atlas: a spatial map of the human proteome Multiproteases combined with high- pH reverse- phase separation strategy verified fourteen missing proteins in human testis tissue Open- pFind enhances the identification of missing proteins from human testis tissue Proteoform: a single term describing protein complexity How many human proteoforms are there? |
| cord-319646-6cex9gid | Creatine supplementation in Walker-256 tumor- bearing rats prevents skeletal muscle atrophy by attenuating systemic inflammation and protein degradation signaling A preliminary, randomized, double- blind, placebocontrolled trial of L- carnosine to improve cognition in schizophrenia Double- blind, placebo- controlled study of l- carnosine supplementation in children with autistic spectrum disorders Functional insights into the creatine transporter Nutraceuticals and dietary supplements to improve quality of life and outcomes in heart failure patients The effect of cold storage on the carnosine content of muscle Metabolism of taurine in microorganisms: a primer in molecular biodiversity? |
| cord-319646-6cex9gid | Does dietary creatine supplementation play a role in skeletal muscle metabolism and performance? |
| cord-319646-6cex9gid | Livestock, dairy, and poultry outlook Mediterranean diet and cardio- metabolic health: what is the role of meat? |
| cord-319646-6cex9gid | Pharmacokinetics and safety of arginine supplementation in animals Proline and hydroxyproline metabolism: implications for animal and human nutrition Dietary requirements of"nutritionally nonessential amino acids"by animals and humans Production and supply of highquality food protein for human consumption: sustainability, challenges and innovations Composition of free and peptide- bound amino acids in beef chuck, loin, and round cuts Metabolism, nutrition and redox signaling of hydroxyproline Significance, challenges and strategies of animal production Creatine and creatinine metabolism Health implications of creatine: can oral creatine supplementation protect against neurological and atherosclerotic disease? |
| cord-319646-6cex9gid | Should dietary guidelines recommend low red meat intake? |
| cord-319646-6cex9gid | The effect of carnosine treatment on prooxidant- antioxidant balance in liver, heart and brain tissues of male aged rats Management of the virulent influenza virus infection by oral formulation of nonhydrolized carnosine and isopeptide of carnosine attenuating proinflammatory cytokine- induced nitric oxide production N- acetylcarnosine, a natural histidine- containing dipeptide, as a potent ophthalmic drug in treatment of human cataracts L- carnosine modulates respiratory burst and reactive oxygen species production in neutrophil biochemistry and function: may oral dosage form of nonhydrolized dipeptide L- carnosine complement anti- infective antiinfluenza flu treatment, prevention and self- care as an alternative to the conventional vaccination? |
| cord-319646-6cex9gid | What is the cause of ageing atrophy? |
| cord-337058-rhu5hp9t | Given our history and our contemporary society, we might wonder why human civilization, since the neolithic revolution seems to be dominated by periods of unsustainability punctuated with periods of socio- ecological crisis and collapse( Ponting 2007; Gowdy and Krall 2013)? |
| cord-337058-rhu5hp9t | Red Queen evolution or stasis? |
| cord-337058-rhu5hp9t | The continuing importance of maximum power Cultural group selection, coevolutionary processes and large- scale cooperation Human carrying capacity is determined by food availability Ancient deforestation revisited Technology as human social tradition: cultural transmission among hunter- gatherers Archeological and environmental lessons for the Anthropocene from the Classic Maya collapse Host density and the evolution of parasite virulence Energetic definition of fitness? |
| cord-337058-rhu5hp9t | The genesis, history, and limits of carrying capacity Burning the land: an ethnographic study of off- site fire use by current and historically documented foragers and implications for the interpretation of past fire practices in the landscape What did Lotka really say? |
| cord-337058-rhu5hp9t | the Gaia hypothesis Ecology, thermodynamics and HT Odum's conjectures Intensive farming: evolutionary implications for parasites and pathogens Perspective: Is human cultural evolution Darwinian? |
| cord-354651-bxm9yxjm | How did Homo sapiens evolve? |
| cord-354651-bxm9yxjm | Inhibitory effect on HT-29 colon cancer cells of a water- soluble polysaccharide obtained from highland barley Antioxidants: positive or negative actors? |
| cord-354651-bxm9yxjm | The hidden costs of dietary restriction: implications for its evolutionary and mechanistic origins Are noncommunicable diseases communicable? |
| cord-354325-r73datur | A role for infectious tolerance? |
| cord-354325-r73datur | How do monoclonal antibodies induce tolerance? |
| cord-354325-r73datur | Tyrosine kinase inhibitors targeted to the epidermal growth factor receptor subfamily: role as anticancer agents Are solid tumor anti- idiotype vaccines ready for prime time? |
| cord-278195-1sle0d1j | Children and adults rapidly detect snakes based on their simple features Last Child in the Woods: Saving our Children from Nature- Deficit Disorder Who Cares About Wildlife? |
| cord-278195-1sle0d1j | For How many species of mammals are there? |
| cord-278195-1sle0d1j | Rather Conspicuous than Endangered? |
| cord-278195-1sle0d1j | Renovables Knowledge and perceptions of Macedonian hunters and herders: the influence of species- specific ecology of bears, wolves, and lynx Human preferences for colorful birds: vivid color or pattern? |
| cord-278195-1sle0d1j | Scary and nasty beasts: self- reported fear and disgust of common phobic animals Which emotions are basic? |
| cord-278195-1sle0d1j | The live bird trade in Brazil and its conservation implications: an overview Toward a psychology of human- animal relations Overcoming Animal and Insect Phobias: How to Conquer Fear of Dogs, Snakes, Rodents, Bees, Spiders and More Consensus on criteria for potential areas for wolf reintroduction in Mexico Prevalence and factors associated with phobias among women Schoolchildren and one of the most unpopular animals: Are they ready to protect snakes? |
| cord-278195-1sle0d1j | What makes some species of milk snakes more attractive to humans than others? |
| cord-278195-1sle0d1j | What's so especial about slithering serpents? |
| cord-278195-1sle0d1j | What's social about social emotions? |
| cord-278195-1sle0d1j | a comparasion of pond owners and non- owners Does colour matter? |
| cord-278195-1sle0d1j | does beauty of animals increase the respondents willingness to protect them? |
| cord-278195-1sle0d1j | will it Take to Put the Action into the Amphibian Conservation Plan? |
| cord-351905-tjcyvkcv | Can targeted reduction of spillover in these high- risk groups be an effective control measure for subcritical pathogens? |
| cord-351905-tjcyvkcv | Should control be targeted at animal- tohuman transmission, human- to- human transmission, or both? |
| cord-351905-tjcyvkcv | The MRSA- import in ICUs is an important predictor for the occurrence of nosocomial MRSA cases Vacated niches, competitive release and the community ecology of pathogen eradication Measles outbreaks in a population with declining vaccine uptake How do resources influence control measures during a simulated outbreak of foot and mouth disease in Australia? |
| cord-351905-tjcyvkcv | Would a reactive strategy which switches from preventing zoonotic spillover to reducing human- to- human transmission be more effective? |
| cord-320005-i30t7cvr | How can we define the limits between what is permitted and what is prohibited, or between privacy and responsibility towards third parties? |
| cord-320005-i30t7cvr | How will it influence medicine? |
| cord-320005-i30t7cvr | If only 1% to 2% of the bases in the human genome code for proteins, then what do the rest do? |
| cord-320005-i30t7cvr | What ethical problems does it pose? |
| cord-320005-i30t7cvr | What general lessons has it taught us so far? |
| cord-320005-i30t7cvr | What was the genesis of this project? |
| cord-320005-i30t7cvr | Why are there so many repetitive sequences in the human genome not found in the genomes of invertebrates? |
| cord-320005-i30t7cvr | has it given rise to? |
| cord-352832-uih7alib | A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special? |
| cord-352832-uih7alib | Bats'fierce immune systems drive viruses to higher virulence, making them deadlier in humans Tip of the iceberg': is our destruction of nature responsible for Covid-19? |
| cord-352832-uih7alib | It is clear that human actions, such as the hunting of wild animals and mindless destruction of biodiversity, create the underlying favorable conditions for new viruses and diseases such as Covid-19, which threaten the existence of humanity itself, so how come humans still engage in destructive behaviors that threaten their own existence? |
| cord-352832-uih7alib | The Guardian Bats as a continuing source of emerging infections in humans Rolling updates on coronavirus disease( COVID-19) Bats and viruses: friend or foe? |
| cord-352832-uih7alib | The emerging role of Buddhism in clinical psychology: toward effective integration Coronavirus outbreak raises question: why are bat viruses so deadly? |
| cord-352798-rb2ggonx | Could billions of individuals, scattered through the world but connected via the internet, become the strongest and most active pillar of environmental protection and thus enhance health and improve social justice? |
| cord-352798-rb2ggonx | How powerful can one individual be? |
| cord-352798-rb2ggonx | Is reducing the risk of transmission by tackling human activities amplifying disease transmission really out of our hands? |
| cord-352798-rb2ggonx | Three concepts of nature coexist: It is a Law project( UNESCO 2016) in which the common heritage dimension is underlined; it is a Legal subject( United Nations 2016); or it is a Law purpose( UNEP 2016)? |
| cord-341155-3d64mso0 | Hepatitis C- contamination of toothbrushes: myth or reality? |
| cord-341155-3d64mso0 | The role of household contacts in the transmission of group A streptococci Salivary cytomegalovirus( CMV) shedding, glycoprotein B genotype distribution, and CMV disease in human immunodeficiency virus- seropositive patients Detection of Ebola virus in oral fluid specimens during outbreaks of Ebola virus hemorrhagic fever in the Republic of Congo Ecology of Haemophilus influenzae and Haemophilus parainfluenzae in sputum and saliva and effects of antibiotics on their distribution in patients with lower respiratory tract infections Varicellazoster virus DNA level and facial paralysis in Ramsay Hunt syndrome Quantitation of varicella- zoster virus DNA in patients with Ramsay Hunt syndrome and zoster sine herpete Practice of feeding premasticated food to infants: a potential risk factor for HIV transmission Detection of human Betaherpesvirinae in saliva and urine from immunocompromised and immunocompetent subjects Human herpesvirus 8 primary infection occurs during childhood in Cameroon, Central Africa Saliva as a diagnostic tool for periodontal disease: current state and future directions Global burden and epidemiology of tuberculosis Epstein- Barr virus reactivation and upper- respiratory illness in elite swimmers Oral fluid, a substitute for serum to monitor measles IgG antibody? |
| cord-341155-3d64mso0 | The utility of whole saliva to detect the oral presence of periodontopathic bacteria Do periodontopathogens disappear after full- mouth tooth extraction? |
| cord-341155-3d64mso0 | report of two cases Oral Helicobacter pylori: can we stomach it? |
| cord-301856-71syce4n | A causal mechanism for childhood acute lymphoblastic leukaemia Association between Helicobacter pylori infection and multiple sclerosis: a systematic review and meta- analysis Is Toxoplasma gondii infection protective against multiple sclerosis risk? |
| cord-301856-71syce4n | Are other newly described genetic regulatory pathways, such as interfering RNA or long noncoding RNAs, also influenced by pathogen- driven evolutionary processes in different populations globally? |
| cord-301856-71syce4n | Are the mechanisms of resistance to infection transmitted only via genetic modifications, or can epigenetic adaptations to resistance also be transmitted to the progeny, and under what circumstances? |
| cord-301856-71syce4n | Are there specific immune processes that are preferentially impacted by evolutionary pressures? |
| cord-301856-71syce4n | Can some of the reasons for these changes lie among some of those bacteria that we have somehow lost in our microbiome? |
| cord-301856-71syce4n | Does caspase-12 suppress inflammasome activation? |
| cord-301856-71syce4n | How does genetic variation of the expression of a specific variant vary between different cell subsets and how does it affect the overall phenotype of an individual within a population? |
| cord-301856-71syce4n | How long does the genome of a given population take to adapt to a new infectious threat? |
| cord-301856-71syce4n | Since many of the variants causing autoimmune diseases are linked to an enhanced responsiveness to pathogens that is no longer needed in developed countries, could these genes and their related pathways be employed as targets for new putative therapeutic approaches against inflammatory/ autoimmune syndromes? |
| cord-301856-71syce4n | We thank Laszlo A. Groh for Which are the strongest evolutionary forces that drive the evolution of the human innate immune system? |
| cord-332569-af8oq2d6 | And is the vaccine likely to be safe? |
| cord-332569-af8oq2d6 | But how do researchers even begin to define these risks and benefits before human clinical trials? |
| cord-332569-af8oq2d6 | Here all of the knowledge accumulated earlier is applied to specific medical questions such as: Will this vaccine protect a pregnant woman( and her baby) from Zika infection? |
| cord-332569-af8oq2d6 | How does the brain work? |
| cord-332569-af8oq2d6 | In human clinical studies, a fundamental question is,"Do the potential benefits of this treatment outweigh the potential risks?" |
| cord-332569-af8oq2d6 | The top 3 benefits of our human/ monkey research partnerships? |
| cord-332569-af8oq2d6 | What is the BRAIN initiative? |
| cord-327063-ea7a1xfl | Avian influenza and sialic acid receptors: more than meets the eye? |
| cord-327063-ea7a1xfl | Based on SARS- CoV Immunological Studies Is COVID-19 receiving ADE from other coronaviruses? |
| cord-327063-ea7a1xfl | COVID-19: what is next for public health? |
| cord-327063-ea7a1xfl | Companion Animal Pets Is COVID-19 the first pandemic that evolves into a panzootic? |
| cord-327063-ea7a1xfl | First respiratory transmitted food borne outbreak? |
| cord-327063-ea7a1xfl | The Indian journal of animal sciences MERS- CoV and now the 2019-novel CoV: Have we investigated enough about coronaviruses? |
| cord-327063-ea7a1xfl | The SARS, MERS and novel coronavirus( COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? |
| cord-327063-ea7a1xfl | What can animal coronaviruses tell us about emerging human coronaviruses? |
| cord-352348-2wtyk3r5 | For example, when should epithelial cells be studied at an air- liquid interface, or when should leukocyte- endothelial interactions be studied under flow? |
| cord-352348-2wtyk3r5 | Improving our use of the models? |
| cord-352348-2wtyk3r5 | Pro: mice are a good model of human airway disease Modelling the human immune response: can mice be trusted? |
| cord-352348-2wtyk3r5 | Pyogenic bacterial infections in humans with IRAK-4 deficiency Severe impairment of interleukin-1 and Toll- like receptor signalling in mice lacking IRAK-4 Phenotypes in asthma: useful guides for therapy, distinct biological processes, or both? |
| cord-352348-2wtyk3r5 | the use of animal models of type 1 diabetes Modelling infectious disease-time to think outside the box? |
| cord-278647-krh63hqp | A Two- year surveillance of 2009 pandemic influenza a( H1N1) in Guangzhou, China: from pandemic to seasonal influenza? |
| cord-278647-krh63hqp | Can reassortment explain these findings? |
| cord-278647-krh63hqp | Could H1N1 ever back- mutate into a strain such as the ancestral genotype that caused the catastrophic 1917- 1918 pandemic? |
| cord-278647-krh63hqp | Does mutation accumulation really have anything to do with virulence? |
| cord-278647-krh63hqp | In light of these findings, what are the medical implications? |
| cord-278647-krh63hqp | Is it feasible that natural selection might fail to remove a large number of deleterious mutations? |
| cord-278647-krh63hqp | Might pandemics be shortened by artificially accelerating the rate of genetic attenuation? |
| cord-278647-krh63hqp | Might the approximately 1,900 nucleotide substitutions be primarily attributed to the genetic drift of perfectly neutral variations? |
| cord-278647-krh63hqp | Might the observed divergence be primarily due to adaptive mutations? |
| cord-278647-krh63hqp | Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China RNA virus error catastrophe: direct molecular test by using ribavirin Implications of high RNA virus mutation rates: lethal mutagenesis and the antiviral drug ribavirin Ribavirin's antiviral mechanism of action: lethal mutagenesis? |
| cord-278647-krh63hqp | Reduction in mortality may be due to many other factors, including herd immunity, advances in medicine, and advances in hygiene, but would these other factors be expected to follow so tightly the time courses seen in Simonsen? |
| cord-278647-krh63hqp | There is abundant evidence for multiple substitutions in specific places that are, in turn, sites of active selection[ 42], but what about the rest of the genome? |
| cord-299315-s43gw24k | But what are the objects, goods, or benefits(and harms) that enable states of heath? |
| cord-299315-s43gw24k | Catastrophic ape decline in western equatorial Africa Potential for Ebola transmission between gorilla and chimpanzee social groups Vaccinating captive chimpanzees to save wild chimpanzees Should protections for research with humans who can not consent apply to research with nonhuman primates? |
| cord-299315-s43gw24k | First, a significant question is'why now?' |
| cord-299315-s43gw24k | How AIDS emerged from an African forest Toward proof of concept of a One Health approach to disease prediction and control From''Us vs. Them''to''Shared Risk'': Can animals help link environmental factors to human health? |
| cord-299315-s43gw24k | Neglected tropical diseases? |
| cord-299315-s43gw24k | Speculations and directions for future research Emerging infections: Condemned to repeat? |
| cord-299315-s43gw24k | The Lancet Can a chimp say''No''? |
| cord-299315-s43gw24k | The duration of the effects of repeated widespread badger culling on cattle tuberculosis following the cessation of culling Has culling been properly assessed as a valid and justified control intervention measure for zoonotic diseases? |
| cord-299315-s43gw24k | Why are clinicians still empty- handed, with no vaccines and no cure? |
| cord-299315-s43gw24k | Why only now has the Ebola virus, which has previously emerged in isolated regions, become a regional endemic( Olival and Hayman 2014; Olson et al. 2012)? |
| cord-346245-o9hvuwvq | 1 0-xylosyl derivatives of 2 0-hydroxyflexixanthin are major carotenoids of Hymenobacter species Modifications of human total serum N- glycome during liver fibrosis- cirrhosis, is it all about immunoglobulins? |
| cord-346245-o9hvuwvq | Is permethylation strategy always applicable to protein N- glycosylation study? |
| cord-346245-o9hvuwvq | Mönch Synthesis of 3,6-branched arabinogalactan- type tetra- and hexasaccharides for characterization of monoclonal antibodies Phosphoglucomutase of Yersinia pestis is required for autoaggregation and polymyxin B resistance Mass spectrometric investigation of molecular variability of grass pollen group 1 allergens Cyclodextrin aldehydes are oxidase mimics Simultaneous glycoproteomics on the basis of structure using ion mobility- mass spectrometry Characterizing ion mobility- mass spectrometry conformation space for the analysis of complex biological samples Effect of ionic liquids as additives in the catalytic properties of different immobilized preparations of Rhizomucor miehei lipase in the hydrolysis of peracetylated lactal Synthetic pseudopterosin analogues: A novel class of antiinflammatory drug candidates Purification, characterization and in vivo studies of salmon heparin Thieme chemistry journal awardees- Where are they now? |
| cord-346245-o9hvuwvq | When can glycopeptides be assigned based solely on high- resolution mass spectrometry data? |
| cord-016095-jop2rx61 | What can teaching, ex cathedra, do to guide the researcher? cord-016095-jop2rx61 , Stanislas DEHAENE( b. 1965), Daniel DENNETT( b. 1942) and others, that thought is not transcendent, and that it is intrinsically dependent on the brain, which is considered to be a neurochemical system, and thus look for the secret of the individuation of the human being in brain information storage mechanisms with retrocontrol loops associated with subtle neuron architectures, or, in short, refer to a sort of TURING machine? cord-016095-jop2rx61 Are the stakes involved in a particular experiment, in terms of the acquisition of new knowledge, worth the suffering of an animal used in that experiment? cord-016095-jop2rx61 At a scientific meeting held in Sheffield, England, in January of 2005 63, with the theme Systems biology: will it work?, an argumentative discussion of the advantages as well as the disadvantages of an integrated, mathematized biology was useful in that it included a reminder that most of the parameters used insystems biology"come from studies that are carried out in vitro on purified enzymes, and that it is not sufficient to know the value of the Michaelian parameters( V max and K m) in order to reach biological reality. |
| cord-016095-jop2rx61 | At what stage of embryo development is it possible to remove ES cells for experimental purposes? |
| cord-016095-jop2rx61 | How can the sum of the scattered experimental data that we have concerning the catalytic capabilities of a multitude of enzymes of cellular origin be integrated into the operation of a cell? |
| cord-016095-jop2rx61 | How can we envisage the gene- enzyme relationship according to current evidence concerning the complexity of the genetic message? |
| cord-016095-jop2rx61 | How could this be true if the teaching faculty did not itself participate in scientific creation? |
| cord-016095-jop2rx61 | In a text entitled Why genetic engineering should continue its battle 31, James WATSON writes of his confusion when faced with a choice that is likely to become more and more insistent over the years:"Dare we be entrusted with improving on the results of several million years of Darwinian natural selection? |
| cord-016095-jop2rx61 | In his What is Bioethics? |
| cord-016095-jop2rx61 | Innumerable cargoes have already reached port, but what will be the destiny of this precious merchandise? |
| cord-016095-jop2rx61 | Is it not necessary to ensure that the experimental protocol is well- documented, that it is not redundant, or even that it has been the subject of previous studies carried out on cells in culture? |
| cord-016095-jop2rx61 | Should"systems biology"be regarded as a resurgence of a physiology that has been somewhat neglected over the last few decades, but has been reinvigorated by a salutary hybridization of biologists and model- makers? |
| cord-016095-jop2rx61 | This example highlights a harrowing ethical dilemma: should we not treat a patient whose illness is likely to be fatal, or attempt a therapy that may save the patient, without having any formal assurance of its success? |
| cord-016095-jop2rx61 | With such an innovation, an unexpected field of exploration has opened up to research in domains as far apart as pharmacology and the science of evolution, giving rise to burning questions: could such non- natural proteins have therapeutic properties? |
| cord-016095-jop2rx61 | could they give a selective advantage to the organisms that host them? |
| cord-016095-jop2rx61 | or do the human germ cells represent on the contrary Rubicons that geneticists will never dare to cross? |
| cord-146850-5x6qs2i4 | How does someone feel about how their life is going?is a pretty powerful question that gives a surprising amount of insight into well- being distanced from what might be influencing them at the moment because it makes them pause and reflect on what matters to them. |
| cord-146850-5x6qs2i4 | Are we ready for a future where our last bastion, the creative pursuit, against the rise of machines is violently snatched away from us? |
| cord-146850-5x6qs2i4 | Artificial Intelligence and the Future of Labor Demand Do increasing efficiency and social benefits stand in exclusion to each other when it comes to automation technology? |
| cord-146850-5x6qs2i4 | But, is there a way that we can grasp that more viscerally where such biases and echo chambers are laid out bare for all to see? |
| cord-146850-5x6qs2i4 | Can I Opt Out of Facial Scans at the Airport? |
| cord-146850-5x6qs2i4 | How do you design so the user can communicate effectively and have transparency so that can you get the right feedback? |
| cord-146850-5x6qs2i4 | It Is Never Neutral Racial Disparities in Automated Speech Recognition Working to Address Algorithmic Bias? |
| cord-146850-5x6qs2i4 | So are there advances in NLP that we could leverage to better automate this process? |
| cord-146850-5x6qs2i4 | So in the deluge of information, what is the key currency that helps us sift through all the noise and identify the signal? |
| cord-146850-5x6qs2i4 | The Wrong Kind of AI? |
| cord-146850-5x6qs2i4 | The Wrong Kind of AI? |
| cord-146850-5x6qs2i4 | The journalist team was able to find at least one advertiser through the"Why am I seeing this ad? |
| cord-146850-5x6qs2i4 | What happens when AI starts to take over the more creative domains of human endeavour? |
| cord-146850-5x6qs2i4 | What's Next for AI Ethics, Policy, and Governance? |
| cord-146850-5x6qs2i4 | What's Next for AI Ethics, Policy, and Governance? |
| cord-146850-5x6qs2i4 | Who's Allowed to Track My Kids Online? |
| cord-146850-5x6qs2i4 | Why is it then, despite the arguments above, that the economic perspective dominates over the ethical one? |
| cord-321993-uazc3lyg | After tortuous millennia of epidemic disease and hundreds of millions dead, who would argue that this was not a most wonderful gift given by humankind to itself? |
| cord-321993-uazc3lyg | How much of human life should be assigned to individuality, and how much to society?" |
| cord-321993-uazc3lyg | In On Liberty, in Chapter IV, John Stuart Mill asks,"What then is the rightful limit to the sovereignty of the individual over himself? |
| cord-321993-uazc3lyg | It can eliminate a disease from the world for all time, saving all future generations, but at what cost? |
| cord-321993-uazc3lyg | We human beings are remarkable in many ways, but why are we remarkable for playing host to so many infectious agents? |
| cord-321993-uazc3lyg | What does the world look like in the face of measles? |
| cord-321993-uazc3lyg | What is the safety of vaccination? |
| cord-321993-uazc3lyg | Where does the authority of society begin? |
| cord-321993-uazc3lyg | Why is it that we must maintain high levels of vaccine coverage to prevent infectious agents from sickening or even killing large swaths of the population? |
| cord-023488-jf2xl3vl | : can we ever expect the unexpected? |
| cord-023488-jf2xl3vl | And when did HIV spread from the first human cases to become a global plague? |
| cord-023488-jf2xl3vl | Are camels the main source of human infections? |
| cord-023488-jf2xl3vl | From an epidemiological viewpoint, why did this outbreak of Ebola explode into a massive pandemic, in contrast to the many prior outbreaks that were limited to no more than a few hundred cases at most? |
| cord-023488-jf2xl3vl | How do camels become infected? |
| cord-023488-jf2xl3vl | Is computer modeling a useful adjunct to the analysis or control of emerging viral diseases? |
| cord-023488-jf2xl3vl | Is this an evolving outbreak, and if so, what is driving it? |
| cord-023488-jf2xl3vl | The emergence of HIV may be divided into two phases: What was the zoonotic source of HIV and when did it cross into humans? |
| cord-023488-jf2xl3vl | The first question that confronts the investigator faced with a disease of unknown etiology is whether or not it has an infectious etiology? |
| cord-023488-jf2xl3vl | What has caused this disease to emerge in 2012, or had it preexisted but was just recognized at that time? |
| cord-023488-jf2xl3vl | What is the origin of this new disease? |
| cord-023488-jf2xl3vl | Where did it come from? |
| cord-023488-jf2xl3vl | Where will it end? |
| cord-023488-jf2xl3vl | Why did it cause a pandemic? |
| cord-023488-jf2xl3vl | Why did the international health community fail to control it? |
| cord-023488-jf2xl3vl | Why then did poliomyelitis emerge abruptly as an epidemic disease? |
| cord-289003-vov6o1jx | Also, is it the right strategy in that it banks more on cure than on anticipation? |
| cord-289003-vov6o1jx | Are there geographic areas in which these emerging infections are more frequently or widely observed today? |
| cord-289003-vov6o1jx | Are there more cases today? |
| cord-289003-vov6o1jx | Are we witnessing an increased frequency of EIDs appearance? |
| cord-289003-vov6o1jx | Based on this, is it possible to prevent the virus'transmission to humans? |
| cord-289003-vov6o1jx | Can we predict patterns, or rules, of emergence? |
| cord-289003-vov6o1jx | Do we possess the scientific ability to predict exactly where the next infectious epidemic will start? |
| cord-289003-vov6o1jx | How to provide care to patients in the case of new EIDs? |
| cord-289003-vov6o1jx | Is it possible to narrow the time gap between the beginning of an epidemic and its detection by the healthcare services? |
| cord-289003-vov6o1jx | What are governments doing faced with this type of threat when the demands on the part of the population are ever- increasing? |
| cord-289003-vov6o1jx | What are the major factors in the emergence of new infectious pathogens in humans? |
| cord-289003-vov6o1jx | What has been, or is, the extent of nosocomial infection's role in the transmission of SARS- CoV and MERS- CoV? |
| cord-338889-7hd3iibk | But what exactly is the role of research ethics? |
| cord-338889-7hd3iibk | Key criteria for the ethical acceptability of COVID-19 human challenge studies Human Challenge Trials for a COVID-19 Vaccine: Should we bother about exploitation? |
| cord-338889-7hd3iibk | Rose title: Back to WHAT? |
| cord-338889-7hd3iibk | Should we accept the'neo- Krugman'ian'views advocated by proponents of Covid-19 CHIs, or should we rely on the normative principles that were formulated as a reaction to the kind of studies Southam and Krugman had conducted? |
| cord-338889-7hd3iibk | Should we infect healthy people with coronavirus? |
| cord-338889-7hd3iibk | So where does all this lead us? |
| cord-338889-7hd3iibk | The Authority of the Investigator, Subject, Profession, and State in the Human Experimentation Process Vulnerability: What kind of principle is it? |
| cord-338889-7hd3iibk | Time to consider SARS- CoV-2 challenge studies? |
| cord-351665-6gwb900b | COVID-19 as a factor influencing air pollution?. |
| cord-351665-6gwb900b | COVID-19 impact on fruit and vegetable markets Is Coronavirus Reducing Noise Pollution? |
| cord-351665-6gwb900b | COVID-19: Water scarcity lurking in crisis? |
| cord-351665-6gwb900b | How Should Policy Responses to the COVID-19 Pandemic Differ in the Developing World? |
| cord-351665-6gwb900b | This is what the economic fallout from coronavirus could look like? |
| cord-351665-6gwb900b | euronews Coronavirus lockdown gives animals rare break from noise pollution Effect of restricted emissions during COVID-19 on air quality in India Lockdown caused by COVID-19 pandemic reduces air pollution in cities worldwide Respiratory viral infections and effects of meteorological parameters and air pollution in adults with respiratory symptoms admitted to the emergency room Airlines and TSA report 96% drop in air travel as pandemic continues Coronavirus Disease( COVID-19) Epidemic among the General Population in China Communicating and Managing Uncertainty in the COVID-19 Pandemic: A quick guide? |
| cord-351665-6gwb900b | what to do with it? |
| cord-310905-1oqfh8of | Bell further says that the question now is'Not what AI but Whose AI? |
| cord-310905-1oqfh8of | But what exactly is AI in 2020, and why does it loom very large in our conversations about the future? |
| cord-310905-1oqfh8of | I, or you?"). |
| cord-310905-1oqfh8of | If this bounded algorithmic agency lacks ethical constraints, then what makes us assured that the prediction paradigm can be tamed by ethical and moral constraints, when it comes to the automation of human behaviour and emotion? |
| cord-310905-1oqfh8of | Should I kill or rather not? |
| cord-310905-1oqfh8of | So what went wrong on the way to seeking human- like intelligence? |
| cord-310905-1oqfh8of | The Guardian Decolonising Artificial Intelligence? |
| cord-310905-1oqfh8of | What work is it doing and why?' |
| cord-310905-1oqfh8of | Who needs imagination when there are facts? |
| cord-310905-1oqfh8of | Who was it who ruined her? |
| cord-310905-1oqfh8of | Would AI look differently in different countries- different data sets and different logics, what do AIs know, and what might they do? |
| cord-310905-1oqfh8of | Your calculus may be greater than his calculus but will it pass the Sullenberger Hudson river test? |
| cord-337659-x4oywbrj | But, just how much of an improvement would that be? |
| cord-337659-x4oywbrj | In considering the gaps in the U.S. agriculture and food defense capabilities, the main question that must be addressed is: Exactly what level of security do the people of the USA want the agricultural industry to achieve, and our government to enforce, in terms of food safety and biosecurity? |
| cord-337659-x4oywbrj | Molecular evolution and the feasibility of an avian influenza virus becoming a pandemic strain-A conceptual shift Pandemic influenza: are we ready? |
| cord-337659-x4oywbrj | Or, will this threat diminish before it evolves into a more human- specific virus? |
| cord-337659-x4oywbrj | So, how can this be achieved? |
| cord-337659-x4oywbrj | So, how could this be improved? |
| cord-337659-x4oywbrj | This was considered an accidental outbreak, but what if it had been a deliberate attack? |
| cord-337659-x4oywbrj | Will this fine dividing line be crossed soon? |
| cord-276954-6m74kejh | , it loves me not: is it morally problematic to design sex robots that appear to love their owners? |
| cord-276954-6m74kejh | : could technology meet astronauts'intimate needs? |
| cord-276954-6m74kejh | An integrative theoretical framework for understanding sexual motivation, arousal, and behaviour Are social media a problem or a tool? |
| cord-276954-6m74kejh | Are we ready for sex robots? |
| cord-276954-6m74kejh | Can we control it? |
| cord-276954-6m74kejh | Does the robot have a mind? |
| cord-276954-6m74kejh | Is sex with robots rape? |
| cord-276954-6m74kejh | Sex and reason Does the chimpanzee have a theory of mind? |
| cord-276954-6m74kejh | The ethics of robot prostitutes Making out with the world and valuing relationships with humans Robot ethics: mapping the issues for a mechanized world Rising- trailer Sex differences in attraction to familiar and unfamiliar opposite- sex faces: men prefer novelty and women prefer familiarity Feminist philosophy of technology Darwin's devices: what evolving robots can teach us about the history of life and the future of technology Validating a virtual environment for sexual assault victims You can do that?! |
| cord-276954-6m74kejh | The history of sexuality volume 1: an introduction It is an agent, or just a program?: a taxonomy for autonomous agents Technofetishism and the uncanny desires of A Freud S( 1973- 1986) |
| cord-276954-6m74kejh | The symbolic- consequences argument in the sex robot debate Regulating child sex robots: restriction or experimentation? |
| cord-276954-6m74kejh | The synthetic hyper femme: on sex dolls, fembots, and the future of sex Machine theory of mind Machine behaviour Love at first swipe? |
| cord-276954-6m74kejh | What exactly is an unusual sexual fantasy? |
| cord-276954-6m74kejh | Who, what, where, when( and maybe even why)? |
| cord-276954-6m74kejh | how the smartphone apps can improve your sexual wellbeing? |
| cord-340101-n9zqc1gm | A meta- analysis Are there theory of mind regions in the brain? |
| cord-340101-n9zqc1gm | Across the entire lifespan, to what extent does reduced social stimulation or too few social contacts lead to loss in general capacities of the cognitive repertoire? |
| cord-340101-n9zqc1gm | Adult attachment style is associated with cerebral μ- opioid receptor availability in humans: Opioids and Attachment Building blocks of social cognition: Mirror, mentalize, share? |
| cord-340101-n9zqc1gm | But how is regular social stimulation reflected in neurobiology? |
| cord-340101-n9zqc1gm | Did distance matter before the Internet? |
| cord-340101-n9zqc1gm | How much do people struggling with cognitive load have issues maintaining many active social relationships? |
| cord-340101-n9zqc1gm | Or both? |
| cord-340101-n9zqc1gm | The Anatomy of Friendship How many hours does it take to make a friend? |
| cord-340101-n9zqc1gm | What further refinements of online digital media might improve people's function in creating and maintain friendships, especially for the housebound? |
| cord-340101-n9zqc1gm | What's in a smile? |
| cord-340101-n9zqc1gm | Which neurobiological mechanisms explain how the default mode network and its connections to subordinate brain systems support higher social capacities, and their decline in social deprivation? |
| cord-281836-j1r771nq | ( Ace) networks for a Pseudomonas aeruginosa model Antibiotic cycling and antibiotic mixing: which one best mitigates antibiotic resistance? |
| cord-281836-j1r771nq | A global view of antibiotic resistance Is El Nino a long- distance corridor for waterborne disease? |
| cord-281836-j1r771nq | A new antibiotic kills pathogens without detectable resistance Oxford: University of Oxford in Michaelmas term 1832/ by Individual freedom versus collective responsibility: too many rights make a wrong? |
| cord-281836-j1r771nq | Covid-19? |
| cord-281836-j1r771nq | Do we need to put society first? |
| cord-281836-j1r771nq | Present- day mercury resistance transposons are common in bacteria preserved in permafrost grounds since the Upper Pleistocene Wastewater bacterial communities bring together broad- host range plasmids, integrons and a wide diversity of uncharacterized gene cassettes Limited dissemination of the wastewater treatment plant core resistome Could bacteriophages transfer antibiotic resistance genes from environmental bacteria to humanbody associated bacterial populations? |
| cord-281836-j1r771nq | The biological cost of mutational antibiotic resistance: any practical conclusions? |
| cord-281836-j1r771nq | The role of natural environments in the evolution of resistance traits in pathogenic bacteria Natural antibiotic resistance and contamination by antibiotic resistance determinants: the two ages in the evolution of resistance to antimicrobials General principles of antibiotic resistance in bacteria Interactions among strategies associated with bacterial infection: pathogenicity, epidemicity, and antibiotic resistance Predicting antibiotic resistance Beyond serial passages: new methods for predicting the emergence of resistance to novel antibiotics What is a resistance gene? |
| cord-281836-j1r771nq | What and how should we tell travellers about antimicrobial resistance? |
| cord-281836-j1r771nq | a united states perspective Chemical- genetic profiling reveals limited cross- resistance between antimicrobial peptides with different modes of action Global increase and geographic convergence in antibiotic consumption between Extended- spectrum betalactamase- producing Escherichia coli from retail chicken meat and humans: comparison of strains, plasmids, resistance genes, and virulence factors Towards a common definition of global health Abiotic gene transfer: rare or rampant? |
| cord-281836-j1r771nq | integrons and gene cassettes between bacterial species Does the recent growth of aquaculture create antibiotic resistance threats different from those associated with land animal production in agriculture? |
| cord-281836-j1r771nq | the widespread Pseudomonas aeruginosa Sequence Type 175 international high- risk clone through whole- genome sequencing Hospital effluent: a reservoir for carbapenemase- producing Enterobacterales? |
| cord-281836-j1r771nq | turning evolutionary principles into clinical reality Antibiotic resistance and its cost: is it possible to reverse resistance? |
| cord-281836-j1r771nq | what's new? |
| cord-348100-jr923fcu | ( Gan et al. 2016)? |
| cord-348100-jr923fcu | At the current stage of being directly affected by the virus, We face other urgent issues as well: How do We protect ourselves, how do We slow down the spread of the virus, and how do We show solidarity in the fight against this virus? |
| cord-348100-jr923fcu | COVID-19—does social distancing include species distancing? |
| cord-348100-jr923fcu | How will We co- exist with non- human species in the future? |
| cord-348100-jr923fcu | Is there a We at all? |
| cord-348100-jr923fcu | So how do We proceed? |
| cord-348100-jr923fcu | What do our global food systems look like? |
| cord-348100-jr923fcu | What does the Anthropocene imply? |
| cord-348100-jr923fcu | Where do We stand? |
| cord-350569-dtxtjtfo | Does Christman, who criticises Frankfurtian theories of autonomy, provide a more realistic perspective? |
| cord-350569-dtxtjtfo | If indeed humans are self- rulers and rational players, why should social stigma prevent them from making self- rational and moral decisions in directing their own HIV medical therapy for their own good, and direct their lives as they deem fit? |
| cord-350569-dtxtjtfo | If to be autonomous is to be self- governing or self- directing or, in other words, to act on motives, values, and reasons that are one's own, then how can we restrict non- autonomous action to only false/ oppressive socialisation? |
| cord-350569-dtxtjtfo | Is this not conceptually and practically conflicting? |
| cord-350569-dtxtjtfo | Or there is n't a need to rethink because humans are, as Kantian and related notions of autonomy tell us, normatively and narratively sovereign selves? |
| cord-350569-dtxtjtfo | Therefore, does this temptation and pursuit to view ourselves as autonomous HIV testing decision- makers blind us to an observable reality that shows that as humans we are interdependent and inextricably social and socialised beings? |
| cord-350569-dtxtjtfo | Thus, can Killmister convincingly enumerate in what circumstances exactly an agent can enjoy this limited autonomy, circumstances which are excluded from the susceptibility to socialisation, internalisation, biological influences or environmental changes? |
| cord-350569-dtxtjtfo | Thus, should there be a need to rethink the personal autonomy 1 premising of informed consent requirements in HIV testing in most sub- Saharan African( SSA) countries, since informed consent requirements in HIV testing are mainly premised on personal autonomy? |
| cord-350569-dtxtjtfo | What about Christman's theory of autonomy which Killmister claims is more persuasive? |
| cord-350569-dtxtjtfo | Why should patients be declared and imputed with personal autonomy and yet at the same time blame the impact of social stigma on preventing potential HIV service- users from seeking medical attention? |
| cord-347884-zpzncgiv | A pneumonia outbreak associated with a new coronavirus of probable bat origin Does land- use change increase the abundance of zoonotic reservoirs? |
| cord-347884-zpzncgiv | Are stakeholders and citizens aware of the risks? |
| cord-347884-zpzncgiv | But how calculating the risk of these phenomena? |
| cord-347884-zpzncgiv | COVID-19: what is next for public health? |
| cord-347884-zpzncgiv | Defining a healthy diet: evidence for the role of contemporary dietary patterns in health and disease Humankind versus virus: are we winning the battle but losing the war? |
| cord-347884-zpzncgiv | How is it possible that a virus from a Chinese market has spread to other continents so quickly, penetrating the heart of cities and killing the weakest citizens? |
| cord-347884-zpzncgiv | How to react to these social and environmental changes showing serious health consequences? |
| cord-347884-zpzncgiv | Report based on available data Coronavirus disease( COVID-19-SARS- CoV-2) and nutrition, is the Italian infection suggesting a connection? |
| cord-347884-zpzncgiv | a global challenge Is there an Association Between Exposure to Air Pollution and Severity of COVID-19 Infection? |
| cord-347884-zpzncgiv | recent advancements in analytics and diagnostics Modulation of the immune response to respiratory viruses by vitamin D Vitamin C can shorten the length of stay in the ICU: a meta- analysis Vitamin D deficiency and co- morbidities in COVID-19 patients-a fatal relationship? |
| cord-337218-risqto89 | Ecological risk assessment by the US Environmental Protection Agency( 1998) asks five questions: Is there a problem? |
| cord-337218-risqto89 | How can we manage the risks? |
| cord-337218-risqto89 | How can we summarize and explain the problem to affected parties, both at- risk populations and those whose activities would be curtailed? |
| cord-337218-risqto89 | How do we know if aggregate human activity is diminishing life on Earth? |
| cord-337218-risqto89 | It begins to turn our attention away from questions such as, How much stress can landscapes and ecosystems absorb? |
| cord-337218-risqto89 | Its central failing comes from an inability to correctly answer the second question, What is the nature of the problem? |
| cord-337218-risqto89 | We may know that biodiversity's services are worth huge sums of money and that our hometown's ecological footprint is much bigger than the town's physical footprint, but how do we know whether specific actions damage living systems or that other actions benefit them? |
| cord-337218-risqto89 | What are the exposure and ecological effects? |
| cord-337218-risqto89 | What is the nature of the problem? |
| cord-337218-risqto89 | to ones such as, How can responsible human actions protect and restore ecosystems? |
| cord-028721-x6f26ahr | : a multicenter, retrospective, chart review Epididymal anomalies associated with hydrocele/ hernia and cryptorchidism: implications regarding testicular descent Congenital deformities of the testis and epididymis Signifi cance of epididymal and ductal anomalies associated with undescended testis Insulin- like factor 3 gene mutations in testicular dysgenesis syndrome: clinical and functional characterization Testicular dysgenesis syndrome: possible role of endocrine disrupters Ethnic differences in occurrence of TDS-genetics and/or environment? |
| cord-028721-x6f26ahr | A chance association? |
| cord-028721-x6f26ahr | A male with XXYY chromosomes Do the 48 XXYY males have a characteristic phenotype? |
| cord-028721-x6f26ahr | A separate type of motor neuron disease? |
| cord-028721-x6f26ahr | A study including data of 1,335 consecutive boys who underwent testicular biopsy simultaneously with surgery for cryptorchidism Experience of screening for carcinoma- in- situ of the testis among young men with surgically corrected maldescended testes Distribution of carcinoma- in- situ in testes from infertile men Carcinoma- in- situ of the testis: aneuploid cells in semen Cryptorchidism and testicular neoplasia Testicular microlithiasis: sonographic features with pathologic correlation Testicular microlithiasis in a child with torsion of the appendix testis Testicular microlithiasis occurring in a postorchidopexy testis Microcalcifi cations in testicular malignancy: diagnostic tool in occult tumor? |
| cord-028721-x6f26ahr | Cause or effect? |
| cord-028721-x6f26ahr | Glandular changes in the rete testis: metastatic tumour or adenomatous hyperplasia? |
| cord-028721-x6f26ahr | Is bilateral congenital anorchia genetically determined? |
| cord-028721-x6f26ahr | Late presentation of cryptorchidism: The etiology of testicular re- ascent Ascent of the testis: fact or fi ction Incomplete disappearance of the processus vaginalis as a cause of ascending testis Undescended testis: congenital or acquired? |
| cord-028721-x6f26ahr | Spontaneous ascent of the testis Acquired undescended testis Does proximal genitofemoral nerve division induce testicular maldescent or ascent in the rat? |
| cord-028721-x6f26ahr | The interval of development of testicular carcinoma in a patient with previously demonstrated testicular microlithiasis Surveillance of testicular microlithiasis? |
| cord-028721-x6f26ahr | The vanishing testis Is the vanished testis always a scrotal event? |
| cord-028721-x6f26ahr | Ultrastructural and meiotic segregation study Lack of acrosome formation in mice lacking a Golgi protein Human infertility due to production of multiple- tailed References spermatozoa with excessive amounts of DNA Multi- tailed spermatozoa in a case with asthenospermia and teratospermia Human spermatozoa with large heads and multiple fl agella: a quantitative ultrastructural study of 6 cases Chromosomal analysis of spermatozoa with normal- sized heads in two infertile patients with macrocephalic sperm head syndrome Crater defect in human spermatozoa Ultrastructural study of human binucleate spermatids Ultrastructural abnormalities of human spermatozoa Cytoplasmic droplets: the good, the bad or just confusing? |
| cord-028721-x6f26ahr | Wilms'tumor development Nephrogenic rests in Wilms'tumor patients with the Drash syndrome Frasier syndrome, part of the Denys Drash continuum or simply a WT1 gene associated disorder of intersex and nephropathy? |
| cord-028721-x6f26ahr | a generalized or a cell typespecifi c phenomenon? |
| cord-028721-x6f26ahr | clinical signifi cance of resistive index values of the testicular artery measured by Doppler ultrasound as a predictor of testicular histology Testicular function in men treated in childhood for undescended testes Histologic lesions in undescended ectopic obstructed testes Is a testis located at the superfi cial inguinal pouch( Denis Browne pouch) comparable to a true cryptorchid testis? |
| cord-028721-x6f26ahr | forme degradée de cryptorchidie? |
| cord-028721-x6f26ahr | it really a normal variant? |
| cord-276110-zztp61pj | And even if they become better at explaining why certain choices are made, will we be able to understand? |
| cord-276110-zztp61pj | Another immediate objection would be to ask: Are people politically active in today's political systems? |
| cord-276110-zztp61pj | But can computers? |
| cord-276110-zztp61pj | But which humans, when we are discussing AI technocracy? |
| cord-276110-zztp61pj | But who? |
| cord-276110-zztp61pj | How and where is artificial intelligence in the public sector going? |
| cord-276110-zztp61pj | If AI or the MDB make decisions that take us closer to our goals, do we really need to understand how they manage to do so? |
| cord-276110-zztp61pj | If a computer makes a decision, who is held accountable for this decision? |
| cord-276110-zztp61pj | If we had the MDB, and knew that its results were good, would we use it? |
| cord-276110-zztp61pj | If we knew it had always produced good decisions in the past, should we employ it, even if we did not understand how it worked? |
| cord-276110-zztp61pj | Machines are better than us at chess and Go, and if this ability also applies to other well- defined strategic problems, should we not let computers decide for us? |
| cord-276110-zztp61pj | Similarly, if the bureaucrats make decisions beyond politicians'understanding, do we complain? |
| cord-276110-zztp61pj | The Law's new language Artificial entities or moral agents? |
| cord-276110-zztp61pj | The decisions, however, are good, so should they employ it? |
| cord-276110-zztp61pj | The market and the forum: three varieties of political theory Why not epistocracy? |
| cord-276110-zztp61pj | Their authors, or perhaps their owners, who are responsible for using them? |
| cord-276110-zztp61pj | We might even object that we have no test for the morality of our human politicians, so why should we implement one in order to keep robots away from power? |
| cord-276110-zztp61pj | What will really change if AI makes our decisions, instead of bureaucrats? |
| cord-276110-zztp61pj | Where, then, does this lead us? |
| cord-257597-jy4a8al8 | : What's the problem, who is responsible, and what can be done? |
| cord-257597-jy4a8al8 | Can we expect to see a diversification in the sorts of animals commoditised, the destinations offered and array of interactions with animals available? |
| cord-257597-jy4a8al8 | Could this technology be used to contribute to animal welfare goals in animal- based tourism or would it perhaps make it worse? |
| cord-257597-jy4a8al8 | From a compassionate perspective, are there any activities where the use of animals can never be accepted? |
| cord-257597-jy4a8al8 | Given the ostensible incompatibility of these two points of departure, which one ought we to prioritise when there is a conflict? |
| cord-257597-jy4a8al8 | If animals are involved, how many animals need to be involved in a given activity? |
| cord-257597-jy4a8al8 | In animal- based tourism, which level of being should be ascribed moral priority? |
| cord-257597-jy4a8al8 | In light of such profound challenges to animal lives and welfare, what is the future of animal- based tourism? |
| cord-257597-jy4a8al8 | Interesting? |
| cord-257597-jy4a8al8 | Is the interest for the tourism( and thus society) bigger than the cost of the individual animal? |
| cord-257597-jy4a8al8 | Not such smart tourism? |
| cord-257597-jy4a8al8 | Parallel to this and as a result of a few notable scandals( such as Cecil the Lion, Blackfish, and exposures of Phajaan, breaking of the will of elephants to get them docile in Thailand), can we also expect increased scrutiny of the industry in terms of its treatment of animal workers? |
| cord-257597-jy4a8al8 | Society s view of animals'roles in animal- based tourism- How do the perceptions, values and attitudes of tourists correspond to those of tourism operators and animal welfare organizations? |
| cord-257597-jy4a8al8 | The Coronavirus Threat to Wildlife Tourism and Conservation Agri- Tourism: In between Rural Change, Tourism Restructuring and Environmental Imperatives A New Urban Dispositif? |
| cord-257597-jy4a8al8 | The Heart of the Movement? |
| cord-257597-jy4a8al8 | The initial question is: Is there a need to use animals at all? |
| cord-257597-jy4a8al8 | What Do We Know About Wild Boar in Iberia? |
| cord-257597-jy4a8al8 | What will be the long- term impact of the so- called flight shame movement on animal- based tourism abroad? |
| cord-257597-jy4a8al8 | and, e.g., corporate social responsibility to push through improved standards of animal welfare in tourism? |
| cord-330970-6kkqoh7f | I wonder if they were head or body lice-is a wig hair or clothing? cord-330970-6kkqoh7f Can we now view this phenomenon in the same way as the lice, as one of the pair of parasites cospeciating with H. sapiens and the other jumping from non- ancestral archaic humans to the modern human lineage? cord-330970-6kkqoh7f Had this custom arisen to protect them from lice as Zinsser[ 1] suggests? cord-330970-6kkqoh7f Is it a coincidence that three human parasites acquired horizontally from great apes, namely pubic lice, HIV-1 and speculatively HSV-2, are sexually transmitted? cord-330970-6kkqoh7f Might vivax malaria have first adapted to H. erectus as an intermediate between monkeys and humans? cord-330970-6kkqoh7f Over to the microbiologists: What do the bacteria, viruses and fungi tell us? cord-330970-6kkqoh7f So how can humans harbor two clades of louse that diverged from each other over one million years ago, when that separation is tenfold older than the emergence of Homo sapiens? cord-330970-6kkqoh7f So was there duplication and separation of lice in the African anthropoid ape lineage, where they could have occupied separate ecological niches, rather as human head lice and pubic lice do today? cord-330970-6kkqoh7f So where did HSV-2 come from? cord-330970-6kkqoh7f Which came first, nakedness or pubic hair? cord-330970-6kkqoh7f Why do adult humans sport a thick bush of wiry pubic hair, uniquely among primates? cord-330970-6kkqoh7f to op pa ar ra as si it te es s?? cord-330970-6kkqoh7f to op pa ar ra as si it te es s?? cord-318061-xe8lljz0 : How Can Companion Animals Help in Connection with Coronary Heart Disease, Obesity, Diabetes and Depression? cord-318061-xe8lljz0 : Is there risk with breed ownership? cord-318061-xe8lljz0 : What are the risks? cord-318061-xe8lljz0 A One Health perspective European dog owner perceptions of obesity and factors associated with human and canine obesity The impact of pets on human health and psychological well- being fact, fiction, or hypothesis? cord-318061-xe8lljz0 A review with consideration of comparative aspects Neurophysiological correlates of affiliative behaviour between humans and dogs Human interaction and cortisol: Can human contact reduce stress for shelter dogs? cord-318061-xe8lljz0 An epidemiologic study Celebrating International Mud Day Dogs and transmission of infection to man, respected member of the family? cord-318061-xe8lljz0 Being licked by a dog can be fatal: Capnocytophaga canimorsus sepsis with purpura fulminans in an immunocompetent man How many people have been bitten by dogs? cord-318061-xe8lljz0 Do the stereotypies of pigs, chickens and mink reflect adaptive species differences in the control of foraging? cord-318061-xe8lljz0 Dominance in domestic dogs revisited: Useful habit and useful construct? cord-318061-xe8lljz0 How much of the potential pathogen is needed to become a health risk? cord-318061-xe8lljz0 How serious is the disease, what is the chance of complications, and what economic consequences may be expected( e.g., labor hours lost)? cord-318061-xe8lljz0 Intern Overweight in adult cats: A cross- sectional study Raw diets for dogs and cats: A review, with particular reference to microbiological hazards Evaluation of raw food diets for dogs Alternative& raw food diets: What do we know? cord-318061-xe8lljz0 Is that a problem? cord-318061-xe8lljz0 NDM-5 ST167 and CTX- M-9 ST69 Escherichia coli between dogs and humans in a family Zooanthroponotic transmission of drug- resistant Pseudomonas aeruginosa Is your dog empathic? cord-318061-xe8lljz0 New allergies but the same allergens Does pet ownership in infancy lead to asthma or allergy at school age? cord-318061-xe8lljz0 Stress and adaptation in cats( Felis sylvestris catus) housed singly, in pairs and in groups in boarding catteries Effects of density and cage size on stress in domestic cats( Felis sylvestris catus) housed in animal shelters and boarding catteries Stereotypies in carnivores: Does pacing stem from hunting, ranging or frustrated escape? cord-318061-xe8lljz0 Who is exposed to the potential hazard and for how long or how often? cord-018613-83r6lhpo The Electronic Brain? |
| cord-018613-83r6lhpo | ( Men are from Mars, Women from Venus)? |
| cord-018613-83r6lhpo | -what happened next? |
| cord-018613-83r6lhpo | A computer can beat me hands down in predicting what percentage of my patients would respond to a particular medication, but could it deal with the imperfections and frailties of the human mind? |
| cord-018613-83r6lhpo | But is it possible? |
| cord-018613-83r6lhpo | But is the internet more complex than the human brain? |
| cord-018613-83r6lhpo | But what if humans could'lend'a computer some conscious awareness? |
| cord-018613-83r6lhpo | But with your brain and without your existing form, would that really be you? |
| cord-018613-83r6lhpo | Do n't you see,"says one character, inviting Mark into the fellowship,"that we are offering you the unspeakable glory of being present at the creation of God Almighty? |
| cord-018613-83r6lhpo | How does the ancient brain beat the power of modern computers? |
| cord-018613-83r6lhpo | If they could replicate the nervous system of this creature and implant that'brain'into another body, would that body behave like a worm? |
| cord-018613-83r6lhpo | Is n't life about celebrating differences? |
| cord-018613-83r6lhpo | It's all very well messing about with a tiny nervous system, but if we were to build a truly human brain, could we control this being? |
| cord-018613-83r6lhpo | Now we ask:'Are you aware of the ball?' |
| cord-018613-83r6lhpo | Siri- ous Business DARPA challenges researchers to link human brains with computers We ask:'What's there?' |
| cord-018613-83r6lhpo | The question more to the point would be: What do you want to become? |
| cord-018613-83r6lhpo | Therefore if your computer can not wake itself up every morning, it can not be conscious, right? |
| cord-018613-83r6lhpo | We ask:'What are the properties of the ball?' |
| cord-018613-83r6lhpo | Will the future be dystopian and Utopian? |
| cord-018613-83r6lhpo | You like chess?' |
| cord-018613-83r6lhpo | a computer was capable of calculating possible moves faster than a human?' |
| cord-300969-a3zcggf2 | A composite of multiple signals distinguishes causal variants in regions of positive selection Genomic imprinting and kinship: how good is the evidence? |
| cord-300969-a3zcggf2 | Britain Literature review: should antipyretic therapies routinely be administered to patients with[ corrected] fever? |
| cord-300969-a3zcggf2 | Can any organisms be potentially immortal? |
| cord-300969-a3zcggf2 | Epidemiology meets evolutionary ecology Evolutionary science and society: educating a new generation Principles of evolutionary medicine Cancer causation: the Darwinian downside of past success? |
| cord-300969-a3zcggf2 | George Williams'work spurred us to ask"What is the role of evolutionary biologists in promoting evolutionary thinking in medical education and practice? |
| cord-300969-a3zcggf2 | Is menopause a life- history trait shaped by selection, or an epiphenomenon? |
| cord-300969-a3zcggf2 | The double- edged sword: how evolution can make or break a live- attenuated virus vaccine Evolutionary explanations in medical and health profession courses: are you answering your students''why'questions? |
| cord-300969-a3zcggf2 | What is the evolutionary explanation for aging? |
| cord-300969-a3zcggf2 | When antibiotic use is terminated in a community, what happens to antibiotic resistance in the bacterial populations? |
| cord-300969-a3zcggf2 | Why are autoimmune diseases becoming more prevalent in recent decades? |
| cord-300969-a3zcggf2 | Why are humans so vulnerable to drug and alcohol abuse? |
| cord-300969-a3zcggf2 | Why does antibiotic resistance persist after antibiotic use stops? |
| cord-300969-a3zcggf2 | Why does the appendix persist despite causing appendicitis? |
| cord-300969-a3zcggf2 | Why does the human eye have a blind spot? |
| cord-300969-a3zcggf2 | Why has not natural selection shaped childbirth to be less painful and risky? |
| cord-300969-a3zcggf2 | Why? |
| cord-300969-a3zcggf2 | advance life history theory? |
| cord-300969-a3zcggf2 | to protect the urogenital tract against infection Will the polio niche remain vacant? |
| cord-334353-nc2jhemz | ( CUP A Common Law of Human Rights? |
| cord-334353-nc2jhemz | And, if hospital'surge capacity'is a core issue, why has n't there been more investment in public hospitals? |
| cord-334353-nc2jhemz | But what of human rights? |
| cord-334353-nc2jhemz | Do they discredit the NGO or community group campaign? |
| cord-334353-nc2jhemz | Do they feature in the new IHR? |
| cord-334353-nc2jhemz | Do they negotiate with one NGO but not with another? |
| cord-334353-nc2jhemz | For example: Do they address the underlying human rights problem itself, making a project more respectful of human rights? |
| cord-334353-nc2jhemz | It will run as follows: if, as seems to be the case in the counter- terrorism context, security and human rights are increasingly represented as in 45 conflict, with rights struggling to maintain popular confidence, why not use security- specifically, a right to security- as a way to bolster human rights? |
| cord-334353-nc2jhemz | Moreover, even if one accepts the skewing of attention towards preparedness, is n't it the case- it will argue- that the preparedness project is out of balance? |
| cord-334353-nc2jhemz | So, how should a human rights lawyer respond to the panoply of new linkages between health and security and, more specifically, the increasing focus on public health emergency preparedness? |
| cord-334353-nc2jhemz | We ask: how does the identification and management of public health risks, tied explicitly in the IHR to the use of scientific principles and evidence, fit with human rights? |
| cord-334353-nc2jhemz | We develop this perspective by asking the following question: is human rights prepared for public health emergency preparedness? |
| cord-334353-nc2jhemz | Whitty, Noel title: IS HUMAN RIGHTS PREPARED? |
| cord-334353-nc2jhemz | Who, in the end, would choose to be'against preparedness'-especially when one considers the extreme human costs of recent public health emergencies? |
| cord-334353-nc2jhemz | Why does investment in neglected diseases continue to lose out so heavily in terms of funding? |
| cord-334353-nc2jhemz | if so, in what ways? |
| cord-324369-zizyxb6y | Effort is necessary at deeper levels of intentionality and purpose of the organisation to stabilise new configurations with existing ones( effort that deals with questions such as"what is the organisation?"). |
| cord-324369-zizyxb6y | Effort is necessary at the level of meaning to"figure out"new configurations with existing ones( effort that deals with questions such as"what is work?"). |
| cord-324369-zizyxb6y | Effort is necessary at the level of task execution to integrate new configurations with existing ones( effort that deals with questions such as"what is the task and how can we do it better?"). |
| cord-324369-zizyxb6y | Future research could investigate: How to anticipate, sensitise and steer second- and third- order effects of Digital/ Human configurations? |
| cord-324369-zizyxb6y | Future research could, thus, address questions such as: What is the human role in Digital/ Human configurations? |
| cord-324369-zizyxb6y | How can organisations adjust strategic capabilities to operate in more fluid digital work environments? |
| cord-324369-zizyxb6y | How can we avoid creating profoundly unequal tiers of digital work and combat workplace inequity? |
| cord-324369-zizyxb6y | How do strategic leaders engage with social media? |
| cord-324369-zizyxb6y | How does social software change knowledge management? |
| cord-324369-zizyxb6y | How to surface and manage'hidden'digital work to configure Digital/ Human assemblages? |
| cord-324369-zizyxb6y | The Many Faces of Anonymous Managing the crises in intranet implementation: a stage model Social","open"and"participative"? |
| cord-324369-zizyxb6y | This suggests the need to better understand different kinds of configuration work within organisations, with future research addressing questions such as: How to observe the emergence of Digital/ Human configurations? |
| cord-324369-zizyxb6y | What effort and skills are needed to manage evolving digital workplaces? |
| cord-324369-zizyxb6y | What governance models allow for more effective appropriation of Digital/ Human configurations? |
| cord-324369-zizyxb6y | What is the quality( as opposed to quantity) of the work being created for humans? |
| cord-324369-zizyxb6y | What is the role of leadership in managing evolving Digital/ Human configurations? |
| cord-324369-zizyxb6y | What's in IT for employees? |
| cord-324369-zizyxb6y | Who is driving the configuration of digital and human aspects of organisations? |
| cord-023767-rcv4pl0d | A forgotten cause of pseudomembranous colitis dificile toxin in asymptomatic neonates Incidence and origin of C. diflicile in neonates Is C. dificile pathogenic in infants? |
| cord-023767-rcv4pl0d | A variety of recipes for homemade preparations have been described?" |
| cord-023767-rcv4pl0d | Although it has been associated with outbreaks of diarrheal disease988 and has been found more commonly in ill than well controls, the role of I? |
| cord-023767-rcv4pl0d | Although several studies have failed to show an association with diarrhea,%9- 974 most studies have found more Aeromonas isolates among children with gastroenteritis than among~o n t r o l s? |
| cord-023767-rcv4pl0d | Although the predominant serogroup can vary from year to year,239,242,243,z46.249~250 the same strains have been prevalent during the past 40 years in Great Britain?51 Puerto R~ c o? |
| cord-023767-rcv4pl0d | Deep freezing of specimens preserves viable EPEC when a prolonged delay in isolation is necessary?" |
| cord-023767-rcv4pl0d | Diagnosis is not usually made by clinical microbiology laboratory testing because, as with Aeromonas, coliforms can be confused with l? shigelloides unless an oxidase test is performed. |
| cord-023767-rcv4pl0d | For example, I? |
| cord-023767-rcv4pl0d | For most pathogens, the incidence of acute diarrhea peaks in children between 6 months and 4 years old? |
| cord-023767-rcv4pl0d | In 1943, Bra?"isolated a serologically homogeneous strain of E. coli( subsequently identified as serogroup 0111) from 95% of infants with summer diarrhea in England. |
| cord-023767-rcv4pl0d | Infantile enteritis viruses: morphogenesis and morphology Reovirus- like particles in jejunal mucosa of a Japanese infant with acute infectious nonbacterial gastroenteritis Comparison of methods for immunocytochemical detection of rotavirus infections Is lactase the receptor and uncoating enzyme for infantile enteritis( rota) viruses? |
| cord-023767-rcv4pl0d | Less commonly, EPEC is isolated from ascetic fluid'"or purulent exudates209* 2157294*, occasionally, the organism has been recovered from blood c u l t~ r e s? |
| cord-023767-rcv4pl0d | Most newborns dying with diarrheal disease caused by EPEC show no morphologic changes of the gastrointestinal tract by gross or microscopic examination of tiss~ es.~'~'~''Bra?"described such"meager"changes in the intestinal tract that"the impression received was that the term gastroenteritis is incorrect. |
| cord-023767-rcv4pl0d | Plesiomonas shigelloides Comparative in vitro activities of selected antimicrobial agents against Aeromonas species and I? |
| cord-023767-rcv4pl0d | Some EPEC strains may secrete weak enterot~ xins,~~''~'~ but the consensus opinion is that the attaching and effacing lesion constitutes the critical secretory virulence pheno- Clinical pathologic reports reveal the characteristic attachin and effacing lesion in the small intestine of infected infants? |
| cord-023767-rcv4pl0d | The biology of Giardia spp Age- related rate of seropositivity and antibody to Giardia lambliu in four diverse populations Giardia lamblia infections in a cohort of Bangladeshi mothers and infants followed for one year Giardiasis and breastfeeding in urban Africa Local immunity in murine giardiasis: is milk protective at the expense of maternal gut? |
| cord-023767-rcv4pl0d | The characterization and significance of J? shigelloides and A. hydrophila isolated from an epidemic of diarrhea. |
| cord-023767-rcv4pl0d | The enterotoxin is not immunologically related to cholera toxin or the heat LT of Although volunteer studies and studies with monkeys have failed to provide supportive evidence for enteropathog e n i~ i t y? |
| cord-023767-rcv4pl0d | These estimates are somewhat lower than the more than 3 million annual deaths from diarrhea reported in the prior 10 years? |
| cord-023767-rcv4pl0d | Two epidemics of diarrhoeal disease possibly caused by I? |
| cord-023767-rcv4pl0d | a pathogen in the newborn intensive care unit? |
| cord-023767-rcv4pl0d | and I? shigelloides: |
| cord-023767-rcv4pl0d | i s? |
| cord-023767-rcv4pl0d | m~~~'~~~~~'~'~~ which is accompanied by a characteristic attaching- and- effacing histopathologic lesion in the small intestine.12'Enterohemorrhagic E. coli( EHEC) also induces an attaching- and- effacing lesion, but in the colon?' |
| cord-023767-rcv4pl0d | shigelloides A. hydrophila and J? shigelloides as causes of intestinal infections |
| cord-023767-rcv4pl0d | ~r t e d?~'.~~~ |
| cord-023767-rcv4pl0d | ~t e d? |
| cord-015394-uj7fe5y6 | : Do They Change during Pregnancy? |
| cord-015394-uj7fe5y6 | A Role for Intrahepatic GLUT1? |
| cord-015394-uj7fe5y6 | Androgens Influence Human Luteal Cells Function? |
| cord-015394-uj7fe5y6 | Are Contractions at 24- 32 weeks Gestation Less Painful Than Those at Full Term? |
| cord-015394-uj7fe5y6 | Could Confined Placental Mosaicism Account for Adverse Perinatal Outcomes in IVF Pregnancies? |
| cord-015394-uj7fe5y6 | Fact or Fiction? |
| cord-015394-uj7fe5y6 | Following Periconceptional Undernutrition or Twinning in Sheep? |
| cord-015394-uj7fe5y6 | In these experiments we sought to answer the question,'Does anandamide( AEA) work in the same manner as THC?' |
| cord-015394-uj7fe5y6 | Is There Evidence for Aromatase Activity in the Stroma of Postmenopausal Ovaries? |
| cord-015394-uj7fe5y6 | Is There a Role for Fatty Acids in the Pathogenesis of Pre- Eclampsia? |
| cord-015394-uj7fe5y6 | Is There a Seasonal Pattern in the Incidence of Post- Cesarean Endometritis? |
| cord-015394-uj7fe5y6 | Necessary? |
| cord-015394-uj7fe5y6 | Pregnancy Outcome? |
| cord-015394-uj7fe5y6 | Reason To Change Intrauterine Referral Practice in the Netherlands? |
| cord-015394-uj7fe5y6 | Term Preeclampsia: Any Risk for the Neonate? |
| cord-015394-uj7fe5y6 | and What Are the Roles Played by Peroxynitrite in Preeclamptic Women? |
| cord-279255-v861kk0i | ( COVID-19) outbreak: could pigs be vectors for human infections? |
| cord-279255-v861kk0i | 2019 novel coronavirus( 2019-nCoV): what advice can we give to travellers? |
| cord-279255-v861kk0i | : what have we learned? |
| cord-279255-v861kk0i | : what is the role of radiologists? |
| cord-279255-v861kk0i | COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression Increased incidence of gastrointestinal side effects in patients taking hydroxychloroquine: a brand- related issue? |
| cord-279255-v861kk0i | Can SARS- CoV-2 infection be acquired in utero? |
| cord-279255-v861kk0i | Can cats become infected with Covid-19? |
| cord-279255-v861kk0i | Can companion animals become infected with Covid-19? Leading veterinary diagnostic company |
| cord-279255-v861kk0i | Does SARS- CoV-2 has a longer incubation period than SARS and MERS? |
| cord-279255-v861kk0i | However, the real question is, how are we planning to counter the next zoonotic CoV epidemic that is likely to occur within the next 5 to 10 years or perhaps sooner? |
| cord-279255-v861kk0i | Influenza Other Respir Viruses Does hand hygiene reduce SARS- CoV-2 transmission? |
| cord-279255-v861kk0i | More definitive evidence is needed Wuhan virus: Chinese animal markets reopened with almost no precautions China must close down"wet markets Will they ever learn? |
| cord-279255-v861kk0i | Rational vaccine design in the time of COVID-19 Bacillus Calmette Guérin( BCG) vaccination use in the fight against COVID-19-what's old is new again? |
| cord-279255-v861kk0i | Reply to"Does hand hygiene reduce SARS- CoV-2 transmission? |
| cord-279255-v861kk0i | The establishment of reference sequence for SARS- CoV-2 and variation analysis Chloroquine and hydroxychloroquine as available weapons to fight COVID-19 A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19 New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? |
| cord-279255-v861kk0i | The next big threat to global health? |
| cord-279255-v861kk0i | What do we know about the SARS- CoV-2 coronavirus in the environment? |
| cord-279255-v861kk0i | What is the potential impact of the Amazon wildfires on vector- borne and zoonotic emerging diseases? |
| cord-279255-v861kk0i | and now the 2019-novel CoV: have we investigated enough about coronaviruses? |
| cord-279255-v861kk0i | e12591 Infection and rapid transmission of SARS- CoV-2 in ferrets Current therapeutic applications and pharmacokinetic modulations of ivermectin Hydroxychloroquine and ivermectin: a synergistic combination for COVID-19 chemoprophylaxis and/or treatment? |
| cord-279255-v861kk0i | is faecal- oral transmission of SARS- CoV-2 possible? |
| cord-279255-v861kk0i | proactive infection control measures against the emerging Wuhan coronavirus pneumonia in China Emerging viruses without borders: the Wuhan coronavirus China coronavirus: what do we know so far? |
| cord-017112-5men6dfk | Use of animals in research: a science- society controversy? cord-017112-5men6dfk ( 2) Would it be benefi cial for anyone? cord-017112-5men6dfk Alternatively, who would decide things should be or should not be? cord-017112-5men6dfk Are n't we imparting sufferings for the plants and animals by using these tools and technology on them? cord-017112-5men6dfk Autonomy: If one feels it is right, should things move on? cord-017112-5men6dfk Do those rights need protection? cord-017112-5men6dfk Each living being has evolved to grow in one condition, and if we put human gene or fi sh's gene in a plant or animal, what would be its effects? cord-017112-5men6dfk Fatal Cercopithecine herpesvirus 1( B virus) infection following a mucocutaneous exposure and interim recommendations for worker protection Studies on release and survival of biological substances used in recombinant DNA laboratory procedures Health care rights and responsibilities: a review of the European Charter of Patients'Rights Goodbye Dolly? |
| cord-017112-5men6dfk | However, it is important that before we keep on proceeding, we should ask some basic questions to ourselves:( 1) Why am I doing this? |
| cord-017112-5men6dfk | Is inflicting pain in any form, which may be by creating a disease model or studying mutations in animals, ethical or not? |
| cord-017112-5men6dfk | One big question is"Are we authorized to use animals the way we want?" |
| cord-017112-5men6dfk | Or else someone feels it is wrong, should things stop? |
| cord-017112-5men6dfk | Rights and responsibilities: Are we exploiting somebody else's rights? |
| cord-017112-5men6dfk | The changes which unnatural gene transfer might be doing to the environment and the society? |
| cord-017112-5men6dfk | The ethics of human cloning After- birth abortion: why should the baby live What exactly is an exact copy? |
| cord-017112-5men6dfk | Virtue ethics: Is this the best thing to do? |
| cord-017112-5men6dfk | What about evolution? |
| cord-017112-5men6dfk | What are their risks to other animals like birds, insects, and other higher animals( like monarch butterfl y and Bt crops)? |
| cord-017112-5men6dfk | What if GM crops breed with other crops, would the biodiversity be lost? |
| cord-017112-5men6dfk | What is good about it? |
| cord-017112-5men6dfk | What would be effect of this experiment? |
| cord-017112-5men6dfk | What would be harms associated with this work? |
| cord-017112-5men6dfk | What would happen if the gene can fi nd an escape route to introduce itself in other members of that species or other species? |
| cord-017112-5men6dfk | What would happen if the herbicide resistance gene could transfer itself in weeds, generating superweeds? |
| cord-017112-5men6dfk | Who is going to be benefi ted? |
| cord-017112-5men6dfk | Who would protect these? |
| cord-017112-5men6dfk | Would the monogenetic crops, if not able to react appropriately to environmental stress, again face a situation like"Ireland's potato famine"? |
| cord-017112-5men6dfk | why? |
| cord-353609-no3mbg5d | A virus reveals population structure and recent demographic history of its carnivore host Parasites: Proxies for host genealogy and ecology? |
| cord-353609-no3mbg5d | And how might co- infections with these undiscovered viruses influence the dynamics of the more well known viruses? |
| cord-353609-no3mbg5d | And what are the relative roles of genetic relatedness and contact rate for transmission? |
| cord-353609-no3mbg5d | And what are the relative roles of genetic relatedness and contact rate for transmission? |
| cord-353609-no3mbg5d | Are we in the midst of the sixth mass extinction? |
| cord-353609-no3mbg5d | As such, wild populations of rodents can be valuable as model disease systems to address relevant questions like: Are there key hosts for transmission? |
| cord-353609-no3mbg5d | As technology becomes more affordable, and thus accessible, there will be increasing opportunities to ask large- scale questions such as: How does the virosphere vary across space and time? |
| cord-353609-no3mbg5d | Can we use this to define risk of cross- species transmission or to inform conservation efforts? |
| cord-353609-no3mbg5d | Could parasites destabilize mouse populations? |
| cord-353609-no3mbg5d | For instance, what characteristics of hosts and viruses make them more or less likely to be involved in cross- species transmission? |
| cord-353609-no3mbg5d | How do these pathogens flow through populations? |
| cord-353609-no3mbg5d | How does it vary across species? |
| cord-353609-no3mbg5d | How does prevalence vary seasonally or over time? |
| cord-353609-no3mbg5d | How many species? |
| cord-353609-no3mbg5d | Pending questions include: Which geographic areas will experience more disease and conservation problems? |
| cord-353609-no3mbg5d | The peopling of the Pacific from a bacterial perspective Distinguishing human ethnic groups by means of sequences from Heliclobacter pylori: Lessons from Ladakh A parasite reveals cryptic phylogeographic history of its host Are lice good proxies for host history? |
| cord-353609-no3mbg5d | What characteristics of hosts and viruses make them more or less likely to be involved in cross- species transmission events? |
| cord-353609-no3mbg5d | What is the contact rate between the reservoir and humans? |
| cord-353609-no3mbg5d | Which areas pose the highest risk for pandemic spread of pathogens? |
| cord-323311-xl2fv0qx | ( i) Is systems biology too complicated and too expensive to become the pre- eminent approach in virology and immunology? |
| cord-323311-xl2fv0qx | ( ii) Are mathematicians and computer scientists up to the challenges? |
| cord-323311-xl2fv0qx | ( ii) Do bat CoVs persist in bat populations and/or individual bats? |
| cord-323311-xl2fv0qx | ( ii) Is CCHFV able to enter and replicate into these cell lines? |
| cord-323311-xl2fv0qx | ( iii) Do bats control viral infection differently from other mammals? |
| cord-323311-xl2fv0qx | ( iv) How can new principal investigators best be identified and appointed? |
| cord-323311-xl2fv0qx | Amongst Small- Scale Dairy Farmers in Zimbabwe? |
| cord-323311-xl2fv0qx | Does CCHFV modulate the in vitro cellular response? |
| cord-323311-xl2fv0qx | How does functional response compare across the three species? |
| cord-323311-xl2fv0qx | How will new technologies like Next Generation Sequencing impact virus systems biology research, especially in the context of RNA sequencing? |
| cord-323311-xl2fv0qx | In response to the perennial question after any scientific experiment,''Where do we go from here?'' |
| cord-323311-xl2fv0qx | The research objectives were to consider:( i) how does CCHFV affect hepatocarcinoma cell lines? |
| cord-323311-xl2fv0qx | The underlying question which Professor Gray and his research team is tackling is: Which human, animal and environmental factors predict disease? |
| cord-323311-xl2fv0qx | What Confidence Do We Really Have? |
| cord-323311-xl2fv0qx | What are the potential interactions of infected bats with the human population? |
| cord-323311-xl2fv0qx | What are the top functions altered during infection? |
| cord-323311-xl2fv0qx | What did this 6th International Conference on Emerging Zoonoses achieve? |
| cord-323311-xl2fv0qx | What triggers the spillover of bat viruses into other animals? |
| cord-323311-xl2fv0qx | Why do bats seem to be able to co- exist with a great diversity of viruses without showing disease signs? |
| cord-323311-xl2fv0qx | Will the food safety modernization act help prevent Outbreaks of foodborne illness? |
| cord-323311-xl2fv0qx | how to translate breakthroughs into public health practice Development of an algorithm for assessing the risk to food safety posed by a new animal disease and Investigation Teams, and members of the Outbreak Control Integrative deep sequencing of the mouse lung transcriptome reveals differential expression of diverse classes of small RNAs in response to respiratory virus infection Differential activation profiles of Crimean- Congo hemorrhagic fever virus- and Dugbe virus- infected antigen- presenting cells Vaccinomics and personalized vaccinology: is science leading us toward a new path of directed vaccine development and discovery? |
| cord-323311-xl2fv0qx | to better understand influenza virus pathogenesis through a cross- species analysis that considered three crucial questions:( i) which genes change over the course of acute infection? |
| cord-323311-xl2fv0qx | what is the prevalence and diversity of bat CoVs in New World bats? |
| cord-282059-sdumq61z | 3,000 shared controls Prediction from low birth weight to female adolescent depression: a test of competing hypotheses Evolutionary biology of cancer Positive selection in the evolution of cancer Adaptive evolution of genes underlying schizophrenia Sampling the antibiotic resistome Use of Marek's disease vaccines: could they be driving the virus to increasing virulence? |
| cord-282059-sdumq61z | 3603 from the laboratory of genetics Polio vaccines exonerated Is early development in humans a predictive adaptive response anticipating the adult environment? |
| cord-282059-sdumq61z | ; why has selection not eliminated these alleles? |
| cord-282059-sdumq61z | A novel polymorphism associated with lactose tolerance in Africa: multiple causes for lactase persistence? |
| cord-282059-sdumq61z | After all, why kill the host that feeds you? |
| cord-282059-sdumq61z | An evolutionary perspective on psychiatry Life table tests of evolutionary theories of senescence Proximate and evolutionary studies of anxiety, stress, and depression: synergy at the interface Is depression an adaptation? |
| cord-282059-sdumq61z | Another question is whether evolution and medicine is one field, or is it just a collection of applications of different aspects of evolutionary theory? |
| cord-282059-sdumq61z | Are medical research and evolutionary biology better connected? |
| cord-282059-sdumq61z | But what is optimal? |
| cord-282059-sdumq61z | Do doctors need to learn evolution, or is it valuable mainly for researchers? |
| cord-282059-sdumq61z | Does it matter? |
| cord-282059-sdumq61z | Environments, adaptations and evolutionary medicine: Should we be eating a'stone age'diet? |
| cord-282059-sdumq61z | Has natural selection shaped a mechanism to detect and reject a fetus that is likely to succumb early to infection? |
| cord-282059-sdumq61z | How does the mechanism work? |
| cord-282059-sdumq61z | How has this mechanism given a selective advantage? |
| cord-282059-sdumq61z | How would studying medical problems advance evolutionary research? |
| cord-282059-sdumq61z | However, does understanding evolution change dramatically what a physician does in her day- to- day work? |
| cord-282059-sdumq61z | So, why do n't we? |
| cord-282059-sdumq61z | So, why does the body go to the trouble to make a difficultto- excrete toxin? |
| cord-282059-sdumq61z | The Evolutionary Legacy Cancer causation: the Darwinian downside of past success? |
| cord-282059-sdumq61z | The Genetical Theory of Natural Selection Medical Education in the United States and Canada, the Carnegie Foundation for the Advancement of Teaching Models of parasite virulence Dynamics of Cancer: Incidence, Inheritance, and Evolution Cystic fibrosis heterozygote resistance to cholera toxin in the cystic fibrosis mouse model Imperfect vaccines and the evolution of pathogen virulence Large- scale sequencing of human influenza reveals the dynamic nature of viral genome evolution Evolutionary psychopathology: why is n't the mind designed better than it is? |
| cord-282059-sdumq61z | The Selfish Gene Balanced polymorphism selected by genetic versus infectious human disease Bordetella pertussis, the causative agent of whooping cough, evolved from a distinct, human- associated lineage of B. bronchiseptica Evolution in health and disease: the role of evolutionary biology in the medical curriculum Paleolithic nutrition: a consideration of its nature and current implications Evolutionary health promotion Experimental evolution of parasites Challenging the trade- off model for the evolution of virulence: is virulence management feasible? |
| cord-282059-sdumq61z | The question,'Why has natural selection left the body so vulnerable to this disease?'seems very abstract to doctors who need to know right now,'What is the problem? |
| cord-282059-sdumq61z | The question,'Why has natural selection left the body so vulnerable to this disease?'seems very abstract to doctors who need to know right now,'What is the problem? |
| cord-282059-sdumq61z | What benefits could be expected if evolution were brought fully to bear on the problems of medicine? |
| cord-282059-sdumq61z | What is the ontogeny of the mechanism? |
| cord-282059-sdumq61z | What is the phylogeny of this mechanism? |
| cord-282059-sdumq61z | What practical steps will promote the application of evolutionary biology in the areas of medicine where it offers the most? |
| cord-282059-sdumq61z | What treatment is best?' |
| cord-282059-sdumq61z | When they first hear about evolutionary medicine, most doctors ask immediately,'How can I apply it in the clinic today?' |
| cord-282059-sdumq61z | Who would have thought it was to slow aging? |
| cord-282059-sdumq61z | Who would have thought they protect against schistosomes? |
| cord-282059-sdumq61z | Why do we have an appendix and wisdom teeth, a narrow birth canal, arteries prone to atherosclerotic blockage, and cells that can divide out of control? |
| cord-282059-sdumq61z | Why, for example, do genes that predispose to asthma persist? |
| cord-282059-sdumq61z | Why, for instance, does bilirubin exist? |
| cord-282059-sdumq61z | Would efforts to bridge the gap pay off in improved human health? |
| cord-282059-sdumq61z | Would we all be better off without the CCR-5 receptor? |
| cord-282059-sdumq61z | toxic waste or natural defense Evolutionary explanations in medical and health profession courses: are you answering your students''why'questions? |
| cord-282059-sdumq61z | x: is it for real? |
| cord-274219-nh2t1qsl | A few clarifications When flexible routines meet flexible technologies: affordance, constraint, and the imbrication of human and material agencies Deal or no deal? |
| cord-274219-nh2t1qsl | A review of classification algorithms for EEG- based brain- computer interfaces Development trajectory and research themes of foresight How many singularities are near and how will they disrupt human history? |
| cord-274219-nh2t1qsl | Alternatively, is this a matter for politicians and policy makers to regulate upon? |
| cord-274219-nh2t1qsl | Although relatively straightforward for simple queries such as'what is the temperature?', it becomes much more demanding for queries that rely on something that was expressed previously and/ or needs contextual awareness. |
| cord-274219-nh2t1qsl | Are the issues raised something that industry should consensually self- regulate? |
| cord-274219-nh2t1qsl | Business Cycles: a Theoretical, Historical and Statistical Analysis of the Capitalist Process Will computers revolt? |
| cord-274219-nh2t1qsl | First, do artefacts have a genetic code and second, how do artefacts develop; are the Weismanian or Lamarkian models of development appropriate for artefact development? |
| cord-274219-nh2t1qsl | For example, what does it mean to trust in technology, as we might with personal assistants and robots that help in our homes? |
| cord-274219-nh2t1qsl | Further, who owns any resultant IP? |
| cord-274219-nh2t1qsl | How can health and safety concerns, rights such as freedom of speech and individual privacy, and promotion of innovation all be balanced? |
| cord-274219-nh2t1qsl | How can we move beyond speculation, hype, hope and fear to informed discussion and decision making, enhanced forecasting and, thereby, the shaping of this technological future for the benefit of humanity? |
| cord-274219-nh2t1qsl | However, as previously mentioned, if singularity leads to ultra- intelligent technical beings, will they eventually outwit humans as illustrated in the film'Ex Machina'( Garland, 2014), when Ava escapes containment, even if humans have enhanced cognitive abilities? |
| cord-274219-nh2t1qsl | However, as revealed by the Moral Machine platform which gathers a human perspective on moral decisions( MIT, 2019), if placed into a situation where the autonomous vehicle had to choose between the lesser of two evils, for example killing five teenage pedestrians crossing on a red light or two elderly passengers in the vehicle, what should it do? |
| cord-274219-nh2t1qsl | However, this concept is itself problematic as there are different views about what constitutes an affordance, for example, is it merely pertaining to perceptions or is there a cognitive component( Harwood and Hafezieh, 2017)? |
| cord-274219-nh2t1qsl | If Fleck's( 2000) Technology Complex reveals the artefact being embedded within a multi- dimensional human social context, then would there be an equivalence for the collective of technological beings? |
| cord-274219-nh2t1qsl | In summation, this raises questions about what debates should be happening in the immediate future and who should be involved in them? |
| cord-274219-nh2t1qsl | Inf Affordance'-what does this mean? |
| cord-274219-nh2t1qsl | Is the process able to adapt and introduce a change that was not part of its initial programming? |
| cord-274219-nh2t1qsl | Is there another possible trajectory continued through the cyborg that preserves human well- being and identity? |
| cord-274219-nh2t1qsl | Is this the science fiction narrative and associated metaphors taken too far? |
| cord-274219-nh2t1qsl | It identifies four areas for development: autonomy, intelligence, language, and autopoiesis-these are currently technically feasible, and with the speed of future developments, how soon will these scenarios be realised? |
| cord-274219-nh2t1qsl | Likewise, what will it mean to manage technology? |
| cord-274219-nh2t1qsl | Many questions can be raised, notably: Is this mere science fiction or is there a real threat to humanity as stated by Stephen Hawking? |
| cord-274219-nh2t1qsl | Might technological beings want to incorporate biological material into their inorganic composition? |
| cord-274219-nh2t1qsl | Nevertheless, this notion of autonomy is open to debate, raising the question of what is an autonomous technology and what issues may be implied or foreseen? |
| cord-274219-nh2t1qsl | Taking this acceleration to an extreme, will a digital twin enable an intelligent autonomous technological entity to continuously improve itself without humans being aware of what is happening? |
| cord-274219-nh2t1qsl | The New Heraclitus Are You Ready for Gen Z in the Workplace? |
| cord-274219-nh2t1qsl | The New York Times Innofusion Or Diffusation? |
| cord-274219-nh2t1qsl | They could be organised in the form of a collective, communicating with others through the collective network, self- adjusting to the collective will, perhaps in a manner illustrated in the science fiction of Star Trek's Borg Collective? |
| cord-274219-nh2t1qsl | This raises questions about how to preserve human well- being, identity and ultimately survival? |
| cord-274219-nh2t1qsl | This raises such questions as • how might they be organised for tasks, both in terms of'communities'and spatially distributed? |
| cord-274219-nh2t1qsl | This raises the question of what is technology? |
| cord-274219-nh2t1qsl | What are the different taxonomies that have been proposed? |
| cord-274219-nh2t1qsl | What can past technology forecasts tell us about the future? |
| cord-274219-nh2t1qsl | What have we learned? |
| cord-274219-nh2t1qsl | What is Technology? |
| cord-274219-nh2t1qsl | Whilst human intervention may diminish, questions are raised about how these digital complexes will shape communities and, more generally, society, as well as, who/ what controls this? |
| cord-274219-nh2t1qsl | Whilst nano- and bio- technologies have not been explored as these are perhaps part of the world of the cyborg, how would they fit in the world of technological beings? |
| cord-274219-nh2t1qsl | and • if there is inequity, would this create tensions between competing entities/ groups of entities? |
| cord-274219-nh2t1qsl | to institutionalize innovation systems in manufacturing A mobilising concept? |
| cord-274219-nh2t1qsl | what would be the implications for governance, whether centralised, decentralised or distributed? |
| cord-274219-nh2t1qsl | would they adopt specialist functions and hence appropriate forms? |
| cord-274219-nh2t1qsl | • would their relationships be equitable or not? |
| cord-022889-lv6fy6e6 | -Are plant ncRNAs more stable than animal( mammalian) ncRNAs? |
| cord-022889-lv6fy6e6 | -Do changes in RNAse activity, due to pathologies or human polymorphisms, influence dietary exposure? |
| cord-022889-lv6fy6e6 | -Do exogenous ncRNAs( naked RNAs) resist the conditions of the gastrointestinal tract environment? |
| cord-022889-lv6fy6e6 | -How does exogenous RNAs uptake in mammalian cells occur? |
| cord-022889-lv6fy6e6 | -What are the biological barriers for the exogenous RNAs after absorption and entering into the mammalian circulatory system? |
| cord-022889-lv6fy6e6 | -What are the biological barriers to consumed RNAs? |
| cord-022889-lv6fy6e6 | -What are the main differences between mammalian and plant ncRNAs? |
| cord-022889-lv6fy6e6 | -What are the specific tissue barriers to exogenous ncRNA function? |
| cord-022889-lv6fy6e6 | -What is known about the half- life of ncRNAs? |
| cord-022889-lv6fy6e6 | -What is known about the movement of plant ncRNAs? |
| cord-022889-lv6fy6e6 | -What is the cellular fate of exogenous ncRNAs once inside the cell? |
| cord-022889-lv6fy6e6 | -What is the function of plant ncRNAs? |
| cord-022889-lv6fy6e6 | -What routes of administration have been used for RNA- based therapeutics? |
| cord-022889-lv6fy6e6 | -What type of ncRNAs are described in plants? |
| cord-022889-lv6fy6e6 | -Which human or animal cells( i.e. lymphocytes, macrophages, myeloid) are possibly involved in immune responses mediated by plant- derived ncRNAs? |
| cord-022889-lv6fy6e6 | -Which innate immunity mediators( i.e. chemokines, cytokines) have been identified in humans and animals as associated to effects of plant- derived ncRNAs? |
| cord-022889-lv6fy6e6 | -Why is it relevant to consider ncRNA stability outside the organism of origin( plant)? |
| cord-022889-lv6fy6e6 | Because this specific topic is especially salient to future understanding of the possible food/ feed risk assessment of ncRNAs- based GM plants, all the identified studies were further evaluated by title and abstract and their relevance to answering the identified key questions: does the literature describe the effect of exogenous plant- origin ncRNAs when consumed orally? |
| cord-022889-lv6fy6e6 | In silico identification of plant miRNAs in mammalian breast milk exosomes-- a small step forward? |
| cord-022889-lv6fy6e6 | In silico identification of plant miRNAs in mammalian breast milk exosomes-- a small step forward? |
| cord-022889-lv6fy6e6 | Only one key question was identified in the preparatory phase:-What are the biological barriers within the gastrointestinal tract to ingested exogenous RNAs? |
| cord-022889-lv6fy6e6 | Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi Detection of Plant miRNAs Abundance in Human Breast Milk In silico identification of plant miRNAs in mammalian breast milk exosomes-- a small step forward? |
| cord-022889-lv6fy6e6 | Selected full- text studies were analysed for their relevance to answering the following key question:-Is there evidence for influence of exogenous plant ncRNAs on the gut microbiota related to the immune system? |
| cord-022889-lv6fy6e6 | Since these findings are important for the risk assessment of ncRNA- based GM plants, the key question was presented in its positive and negative forms as follow: are there studies describing the presence of exogenous RNAs in the biological fluids and tissues of humans and/or animals? |
| cord-022889-lv6fy6e6 | Studies were further evaluated for their relevance to answer the key questions identified for this section:-What are the pharmacokinetic properties of RNA- based therapeutics? |
| cord-022889-lv6fy6e6 | The complex exogenous RNA spectra in human plasma: an interface with human gut biota? |
| cord-022889-lv6fy6e6 | The complex exogenous RNA spectra in human plasma: an interface with human gut biota? |
| cord-022889-lv6fy6e6 | The key questions identified to refine the literature search for this specific topic were:-Is there evidence of any toxicological effects of plant- derived dietary exogenous ncRNAs? |
| cord-022889-lv6fy6e6 | The key questions identified using the above key words were:-Which test methods or approaches are available to investigate the possible role of plant- derived exogenous ncRNAs on the immune system of humans or animals? |
| cord-022889-lv6fy6e6 | The search was refined by filtering for relevance to answering the identified key questions: is there any clear transport of exogenous ncRNAs into mammalian cells? |
| cord-022889-lv6fy6e6 | To assist and refine the search, studies were further filtered for their relevance to the key question identified: is the oral route of administration relevant for RNA- based therapeutic development? |
| cord-022889-lv6fy6e6 | To more appropriately cover this section and to refine the search, the following key questions were identified during the preparatory phase:-What is the general amount of RNAs naturally occurring in edible plants? |
| cord-022889-lv6fy6e6 | any natural vehicles for oral administration of exogenous ncRNAs? |
| cord-022889-lv6fy6e6 | bee pollen miRNAs in serum of mice Chemical modification patterns compatible with high potency dicer- substrate small interfering RNAs Is RNA interference involved in intrinsic antiviral immunity in mammals? |
| cord-022889-lv6fy6e6 | certain types of plant ncRNAs more or less stable than others? |
| cord-022889-lv6fy6e6 | derived extracellular vesicles attenuates arthritis in two mouse models Exosomes as a Nanodelivery System: a Key to the Future of Neuromedicine? |
| cord-022889-lv6fy6e6 | disease conditions modify the pharmacokinetic properties of RNAs when administered to mammals? |
| cord-022889-lv6fy6e6 | exogenous ncRNAs also used to exert RNAi effects in fish or birds? |
| cord-022889-lv6fy6e6 | exogenous ncRNAs consumed in an amount sufficient to exert a local biological effect?Are there other common examples of exogenous ncRNAs( other than plant- origin) that could exert a biological effect on the GI tract and its annex glands when ingested orally? |
| cord-022889-lv6fy6e6 | exogenous ncRNAs evaluated quantitatively? |
| cord-022889-lv6fy6e6 | exposure to RNAs change in different diet types? |
| cord-022889-lv6fy6e6 | human or animal immune response(s), innate or adaptive, are possibly associated with administration of plant- derived exogenous ncRNAs? |
| cord-022889-lv6fy6e6 | is it known about the pharmacodynamic properties of RNA- based therapeutics? |
| cord-022889-lv6fy6e6 | key questions were identified and the studies then further filtered for their relevance to the these:-Are exogenous RNAs taken up by mammalian cells? |
| cord-022889-lv6fy6e6 | molecular mechanisms are involved in exogenous ncRNAs trafficking inside the cell? |
| cord-022889-lv6fy6e6 | ncRNAs- based therapeutics-delivered by oral administration or other GI tract routes of administration- exert a biological effect in the GI tract or its annex glands? |
| cord-022889-lv6fy6e6 | orthologous of environmental RNAs transporters in lower organisms( i.e. SID family of proteins) involved in the mammalian exogenous ncRNA mechanism of uptake? |
| cord-022889-lv6fy6e6 | percentage of total plant RNAs are ncRNAs, miRNAs, siRNAs, lncRNAs or dsRNAs? |
| cord-022889-lv6fy6e6 | possible interactions related to unintended RNAi- mediated gene regulation? |
| cord-022889-lv6fy6e6 | possibly mediated by administration of plant- derived ncRNAs? |
| cord-022889-lv6fy6e6 | so, what makes a plant ncRNA more stable than its animal( mammalian) counterpart? |
| cord-022889-lv6fy6e6 | stability properties under GI tract conditions normally evaluated? |
| cord-022889-lv6fy6e6 | the literature describe negative results or contradictory results regarding the possible biological effect of ncRNAs when consumed orally? |
| cord-022889-lv6fy6e6 | the toxicological effects related to RNAi- mediated interaction with the human or animal genome? |
| cord-022889-lv6fy6e6 | there studies contradicting the presence of exogenous RNAs in the biological fluids and tissues of humans and/or animals? |
| cord-022889-lv6fy6e6 | types of formulation( delivery vehicles) are tested for RNA- based therapeutics for the oral route of administration or other gastrointestinal tract routes of administration? |
| cord-301537-uu2aykoy | Why start and stop with one loaf and one very local assembly? cord-301537-uu2aykoy A place of endless harmony and balance? cord-301537-uu2aykoy A system involving a constant battle for survival? cord-301537-uu2aykoy An unlimited source of raw materials? cord-301537-uu2aykoy And if solutions within this system are so impossible to find then maybe we should change the system itself? cord-301537-uu2aykoy And if the church is to proclaim the Gospel in every place of need, how do we train students for those contexts? cord-301537-uu2aykoy And when the counsel in such days says that prayer and meditation and listening to the Word isjust as effective anyway,"does that logic not undercut the very reasons the same counselors once argued for regular celebration of Holy Communion? |
| cord-301537-uu2aykoy | Are all trees, therefore, in truth mere objects? |
| cord-301537-uu2aykoy | As Olaf wisely queries,"Did you know that an enchanted forest is a place of transformation? |
| cord-301537-uu2aykoy | As we move forward in this critical period of ecological viability, who will we show ourselves to be? |
| cord-301537-uu2aykoy | Bounded by what? |
| cord-301537-uu2aykoy | But what? |
| cord-301537-uu2aykoy | But will she be able to move us into action? |
| cord-301537-uu2aykoy | But, if God, then why would a good God do such a thing? |
| cord-301537-uu2aykoy | Can we fully step into our power and show our self who is made in the image of the Divine? |
| cord-301537-uu2aykoy | Do we do as in Denmark( with an early and strict lockdown but initially without many Corona tests)? |
| cord-301537-uu2aykoy | Do we proceed as in South Korea and Taiwan( with large screenings of the population and subsequent quarantines)? |
| cord-301537-uu2aykoy | Does it not in itself betray a favored"spiritualism,"if not even a closeted Gnosticism? |
| cord-301537-uu2aykoy | Does such a"low threshold"( Berger, 2018, p. 36) for commitment allow one to flee from any sort of responsibility in the relationship, or does it allow for the freedom of openness without the increased possibility for negative consequences? |
| cord-301537-uu2aykoy | Does the church need to reclaim that part of its history and heritage and make it more central to its mission and identity? |
| cord-301537-uu2aykoy | Does the power of God, which for fickle human consciousness necessarily begins at the physical, end with the physical? |
| cord-301537-uu2aykoy | How are their needs to be met, so that they can meet the needs of Christians? |
| cord-301537-uu2aykoy | How are you doing? |
| cord-301537-uu2aykoy | How do we speak with confidence about the limits of our solidified patterns and hope of restored connection? |
| cord-301537-uu2aykoy | I do not think I am the kind of person who normally sounds alarmist( but who really who thinks that they are alarmist?), but it is hard to imagine that COVID-19 will not remake our lives in ways we never could have envisioned a few months ago. |
| cord-301537-uu2aykoy | I wonder if COVID-19 will not threaten to( further?) |
| cord-301537-uu2aykoy | In such a world being ravaged by an"invisible enemy,"where is one to turn? |
| cord-301537-uu2aykoy | Is COVID-19 such a moment for the church? |
| cord-301537-uu2aykoy | Is it a mechanism that simply keeps on rolling? |
| cord-301537-uu2aykoy | Maybe the corona virus experience teaches us to recover the importance of human communities as well as our place in ecological communities? |
| cord-301537-uu2aykoy | Might we not be at that blinking point of awakened insight now of actually converging our metaphysics and communion practices with the mystical poetry we have sung for millennia? |
| cord-301537-uu2aykoy | Now what? |
| cord-301537-uu2aykoy | Or was it, in truth, a creature in its own right, worthy of my respect, even adulation? |
| cord-301537-uu2aykoy | Or, do we choose like Sweden( avoid strong coercion but appeal to the population)? |
| cord-301537-uu2aykoy | Our enemy? |
| cord-301537-uu2aykoy | Our recreation area? |
| cord-301537-uu2aykoy | Should Christians practice"Virtual Communion"in time of a plague? |
| cord-301537-uu2aykoy | So, is it possible to have Online Communion? |
| cord-301537-uu2aykoy | So, what wisdom can the church glean from Frozen 2? |
| cord-301537-uu2aykoy | The caveat is that in many places, the assembly is not gathering on Sunday mornings, so how would the extended distribution be extended from something that is not happening? |
| cord-301537-uu2aykoy | The source of the pandemic? |
| cord-301537-uu2aykoy | This fact reminds us that it is not only theological education in the seminary that must be discussed; it is not only the education of pastors that needs to be discussed; the question is: how can church leaders of diverse vocations- pastors, deacons, and others- take their education, go forth, and educate through word and deed as part of their broader vocation? |
| cord-301537-uu2aykoy | Was n't it the case that I not only clung to that tree, forty feet above ground, for safety's sake, but also to embrace it? |
| cord-301537-uu2aykoy | Was that Lombard Poplar which I adored when I was 11 years old merely an object I used, like a ladder, to climb up into the sky? |
| cord-301537-uu2aykoy | We can also gain a deep understanding of our mission as human beings, our function: why are we actually here? |
| cord-301537-uu2aykoy | What are more sustainable practices? |
| cord-301537-uu2aykoy | What can we imagine if we have not had the time to reflect and study? |
| cord-301537-uu2aykoy | What is life together if it is virtual and disembodied? |
| cord-301537-uu2aykoy | What kind of a reality do we hope to wake up to after the corona crisis? |
| cord-301537-uu2aykoy | What was going to happen? |
| cord-301537-uu2aykoy | What will it mean for us in the 21st century if we can not gather together in the ways we have always gathered? |
| cord-301537-uu2aykoy | What would our lives be like without close eye contact and bodily expressions of welcome? |
| cord-301537-uu2aykoy | What, then, about my relationship with trees? |
| cord-301537-uu2aykoy | When will we learn to say,"Enough is enough!"? |
| cord-301537-uu2aykoy | Where, then, is God in the midst of pandemic? |
| cord-301537-uu2aykoy | Why has God chosen this particular way of bringing us into life and sustaining us? |
| cord-301537-uu2aykoy | Why is it that our existence is woven on this vast and complex loom of evolution? |
| cord-301537-uu2aykoy | Will we protect the children of the Earth from our unfettered goblin of destruction or will we break the spell and save everyone? |
| cord-301537-uu2aykoy | With"physical distancing"forcing worshipping communities to meet virtually and disembodied, can they matter? |
| cord-301537-uu2aykoy | and they are good? |
| cord-301537-uu2aykoy | if that is not clear to some) and bear on the presenting question? |
| cord-301537-uu2aykoy | what else can we do?-and by intellectual constraints- what else can we imagine? |
| cord-024088-020rgz5t | , on the cognitive level( what is factually correct?), the interest level( what benefits me?), the value level( what is needed for a"good"life?) and the normative level( what can I expect of all involved?). |
| cord-024088-020rgz5t | , on the cognitive level( what is factually correct?), the interest level( what benefits me?), the value level( what is needed for a"good"life?) and the normative level( what can I expect of all involved?). |
| cord-024088-020rgz5t | , on the cognitive level( what is factually correct?), the interest level( what benefits me?), the value level( what is needed for a"good"life?) and the normative level( what can I expect of all involved?). |
| cord-024088-020rgz5t | , on the cognitive level( what is factually correct?), the interest level( what benefits me?), the value level( what is needed for a"good"life?) and the normative level( what can I expect of all involved?). |
| cord-024088-020rgz5t | : Nine Answers to"What Should Be Sustained? |
| cord-024088-020rgz5t | A Tutorial Introduction to Decision Theory A Methodology for Analyzing Emission Control Strategies Why Preserve Natural Variety? |
| cord-024088-020rgz5t | A more desirable or bearable than the consequences of option B?) |
| cord-024088-020rgz5t | A systematic check of the processes and plant parts for effects in normal operation and in case of set point deviations, using selected question words( and-or-not-too much-too little?). |
| cord-024088-020rgz5t | Ambivalenzen des technischen Fortschritts mit einer neuen Ethik meistern kann? |
| cord-024088-020rgz5t | And if yes, which ones? |
| cord-024088-020rgz5t | Are only people included in this principle( this is the codified version valid in most legal constitutions today) or other living creatures, too? |
| cord-024088-020rgz5t | Are the protective measures compatible with each other? |
| cord-024088-020rgz5t | But given the variety of cultures and beliefs, how can standards be justified inter- subjectively, i.e. in a way that is equally valid to all? |
| cord-024088-020rgz5t | But how can agreement be reached on such collectively binding principles and standards? |
| cord-024088-020rgz5t | But how can generally binding and inter- subjectively valid criteria be made for the valuation of"the common good"? |
| cord-024088-020rgz5t | But how can primary principles be justified as equally valid for all people? |
| cord-024088-020rgz5t | But how can this be done given the wealth of competing values and preferences? |
| cord-024088-020rgz5t | But if we disregard the dominant or sub- dominant solutions, an appreciation between options that violate or fulfil compensatory standards and principles depends on two preconditions: best possible knowledge of the consequences( what happens if I choose option A instead of option B?) and a transparent, consistent rationale for weighing up these consequences as part of a legitimate political decision process( are the foreseeable consequences of option |
| cord-024088-020rgz5t | But what does the adoption of categorical principles specifically mean for the political moulding of environmental protection? |
| cord-024088-020rgz5t | But what form should such an appreciation take? |
| cord-024088-020rgz5t | Can Participatory Democracy Produce Better Selves? |
| cord-024088-020rgz5t | Can we rely on risk perception results to judge the seriousness of pending risks? |
| cord-024088-020rgz5t | Decisionmaking Ist die Schöpfung noch zu retten? |
| cord-024088-020rgz5t | Ethics can provide an answer to the question posed in the beginning("Should people be allowed to do everything that they are capable of doing?") in a consistent and transparent manner. |
| cord-024088-020rgz5t | For example: What is the evidence that an environmental management initiative will lead to an improvement, such as reducing losses of agricultural crops to insect pests-and what is the evidence that the management initiative could lead to ecological damage-loss of insects we value, such as bees or butterflies, damage to birds and other predators that feed on insects-and health impacts from the level of pesticides and important nutrients in the food crops we eat? |
| cord-024088-020rgz5t | Has sufficient consideration been given to the consequences that can arise from the use of a machine designed for professional/ industrial use when it is used in a non- professional/ non- industrial context? |
| cord-024088-020rgz5t | Have hazards been eliminated or their risks been reduced to the lowest practicable level? |
| cord-024088-020rgz5t | How can industrialized countries assist the developing countries in carrying out preventive actions? |
| cord-024088-020rgz5t | How can these challenges be met in order to succeed in the growing international competition? |
| cord-024088-020rgz5t | How can we detect whether such an excess has happened and how it can be prevented from the very outset that these inviolable standards and principles be exceeded? |
| cord-024088-020rgz5t | How should priorities be set according to the available resources? |
| cord-024088-020rgz5t | How should this connection be explored? |
| cord-024088-020rgz5t | However, with regard to the primary principles there is a special transfer problem when addressing human interventions into nature and the environment: does the basic postulate of conservation of life apply only to human beings, to all other creatures or to all elements of nature, too? |
| cord-024088-020rgz5t | In other schools of ethics, intuition( can the consequence still be desirable?) |
| cord-024088-020rgz5t | Is it certain that the measures undertaken do not excessively reduce the ability of the machine to perform its intended function? |
| cord-024088-020rgz5t | Is it certain that the measures undertaken do not generate new hazards? |
| cord-024088-020rgz5t | Is it certain that the operator's working conditions are not jeopardized by the protective measures taken? |
| cord-024088-020rgz5t | Is it justified to break a promise when keeping the promise could harm many other people? |
| cord-024088-020rgz5t | Is it not the case that science can only prove or disprove factual statements( and this only to a certain extent), but not normative statements? |
| cord-024088-020rgz5t | Is it the reasonably achievable level or, for example, the level achieved by the best available technology? |
| cord-024088-020rgz5t | Ist biologisches Produzieren natürlich? |
| cord-024088-020rgz5t | Konsens als Telos der sprachlichen Kommunikation? |
| cord-024088-020rgz5t | One has to answer the following questions: • What specific examples of prevention instruments can be offered? |
| cord-024088-020rgz5t | Or should we place all our faith in professional risk management? |
| cord-024088-020rgz5t | Participation and Discourse in Risk Management A Regional Concept of Qualitative Growth and Sustainability-Support for a Case Study in the German State of Baden- Württemberg Was heißt hier Bioethik? |
| cord-024088-020rgz5t | Should non- living elements be included as well? |
| cord-024088-020rgz5t | Should people be allowed to do everything that they are capable of doing? |
| cord-024088-020rgz5t | Should we simply accept the results of opinion polls as the basis for making political decisions? |
| cord-024088-020rgz5t | Suhrkamp, Frankfurt/ M Translator's Introduction Comparative Analysis of Formal Decision- Making Approaches Sustainable Development? |
| cord-024088-020rgz5t | Suhrkamp, Frankfurt/ M Welche Natur sollen wir schützen? |
| cord-024088-020rgz5t | The Environment and Disease: Association or Causation? |
| cord-024088-020rgz5t | The Limits to Safety? |
| cord-024088-020rgz5t | The main conflicts occur at the process level( how should the negotiations be conducted?) |
| cord-024088-020rgz5t | The question arises: Are the extent and probability of the risk known? |
| cord-024088-020rgz5t | Wandelt sich die Verantwortung mit technischem Wandel? |
| cord-024088-020rgz5t | What are the main challenges arising from the major societal changes for business/ companies and workers/ employees? |
| cord-024088-020rgz5t | What are the prerequisites for success? |
| cord-024088-020rgz5t | What contribution do ethics make towards clarifying the prospects and limits of human interventions into the natural environment? |
| cord-024088-020rgz5t | What criteria can be used to judge standards? |
| cord-024088-020rgz5t | What is the role of occupational safety and health( OSH) in this context? |
| cord-024088-020rgz5t | What needs to be deliberated? |
| cord-024088-020rgz5t | What should a mixture of the three elements( due process, pluralistic muddling through and discourse) look like so that a maximum degree of rationality can come about on the basis of social value priorities? |
| cord-024088-020rgz5t | When? |
| cord-024088-020rgz5t | Who can and may draw up such criteria, according to which standards should the interventions be assessed and how can the various evaluative options for action be compared with each other for each criterion? |
| cord-024088-020rgz5t | Why can one expect that deliberative processes are better suited to deal with environmental challenges than using expert judgement, political majority votes or relying on public survey data? |
| cord-024088-020rgz5t | Why should we include this topic in a book that is dominantly dealing with occupational health risks and safety issues? |
| cord-024088-020rgz5t | Wie weit tragen utilitaristische Begründungen? |
| cord-024088-020rgz5t | • Are the users sufficiently informed and warned about the residual risks? |
| cord-024088-020rgz5t | • Have all operating conditions and all intervention procedures been taken into account? |