trigram

This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

trigram	frequency
middle east respiratory	6144
east respiratory syndrome	6128
respiratory syndrome coronavirus	5822
severe acute respiratory	2612
acute respiratory syndrome	2438
of middle east	1910
in saudi arabia	1227
the middle east	1086
as well as	931
syndrome coronavirus infection	729
of severe acute	727
in patients with	691
of the virus	638
the treatment of	617
a novel coronavirus	613
the presence of	587
the number of	585
of a novel	569
in dromedary camels	566
the use of	563
cov and mers	536
the development of	531
world health organization	505
due to the	496
based on the	465
in south korea	453
syndrome coronavirus in	445
of the mers	439
respiratory distress syndrome	435
in this study	427
sars and mers	423
acute respiratory distress	421
with middle east	414
one of the	408
of patients with	387
of novel coronavirus	383
of the sars	380
the risk of	379
the role of	379
for the treatment	379
according to the	368
patients with severe	366
a total of	364
lower respiratory tract	362
cov infection in	361
the spike protein	358
in addition to	358
in order to	350
the s protein	344
of the disease	343
novel coronavirus from	325
the arabian peninsula	318
have been reported	314
the united states	312
coronavirus infection in	311
cov and sars	309
for middle east	307
transmission of mers	302
in the middle	298
republic of korea	297
the novel coronavirus	295
found to be	293
in the lungs	289
the spread of	289
it has been	287
with pneumonia in	287
the absence of	281
upper respiratory tract	280
a systematic review	279
the severe acute	278
with severe acute	276
critically ill patients	276
outbreak of middle	275
patients with covid	274
clinical characteristics of	273
control and prevention	272
the republic of	267
coronavirus from a	267
risk factors for	265
in the united	261
cases of mers	259
the mers outbreak	258
of the middle	255
associated with the	255
the emergence of	253
is associated with	251
of saudi arabia	248
of the s	245
been shown to	242
the world health	240
in the treatment	239
prevention and control	239
has been reported	237
isolation of a	235
treatment of covid	234
the importance of	233
dromedary camels in	233
patients infected with	232
from saudi arabia	230
infected with mers	230
for disease control	230
analysis of the	229
pneumonia in saudi	229
from a man	228
disease control and	228
patients with middle	227
cov cl pro	227
a man with	227
cd t cells	226
man with pneumonia	225
respiratory syndrome in	225
of the novel	222
was used to	221
of mers coronavirus	221
there is no	221
respiratory syncytial virus	220
patients with mers	218
cov s protein	218
such as the	217
cov pl pro	216
the case of	214
related to the	211
the majority of	211
in the republic	211
ill patients with	208
compared to the	206
the effect of	205
a number of	205
novel human coronavirus	205
in hong kong	203
the context of	200
the efficacy of	199
in the case	199
most of the	197
role in the	197
was found to	197
the respiratory tract	196
coronavirus spike protein	195
there is a	195
kingdom of saudi	194
polymerase chain reaction	194
influenza a virus	193
of the viral	193
in the context	192
cov spike protein	189
structure of the	189
in the same	189
of the spike	188
of cases of	188
case fatality rate	186
the possibility of	186
in the presence	182
functional receptor for	182
the expression of	182
as shown in	181
ministry of health	181
associated with a	181
in combination with	181
cases of middle	179
was associated with	179
with acute respiratory	178
novel coronavirus in	178
for patients with	177
vero e cells	177
characterization of a	176
the sars coronavirus	176
in the absence	176
and clinical characteristics	176
the impact of	175
infection in the	175
in terms of	175
to be a	175
a and b	175
intensive care unit	174
a combination of	174
the detection of	174
the lack of	174
has also been	171
the incubation period	171
was detected in	169
of viral rna	169
on the other	168
united arab emirates	168
infected with sars	168
to be the	167
the pathogenesis of	167
showed that the	166
need to be	166
emerging infectious diseases	166
saudi arabia middle	165
arabia middle east	165
the fact that	164
the other hand	164
outbreak in south	164
cov outbreak in	163
understanding of the	162
type i interferon	162
centers for disease	161
were found to	161
been reported to	161
a functional receptor	161
the host cell	160
the time of	159
in vitro and	159
the need for	158
innate immune response	158
and characterization of	157
a descriptive study	157
the results of	157
the present study	155
the transmission of	155
to evaluate the	155
of sars coronavirus	155
more likely to	154
ribavirin and interferon	154
health care workers	154
the severity of	154
of the patients	153
receptor for the	153
h n influenza	153
respiratory tract infections	153
the outbreak of	152
spread of the	152
and outcomes of	152
the course of	152
well as the	151
balb c mice	151
has been shown	151
a recent study	150
to determine the	150
of the coronavirus	150
none of the	150
mers outbreak in	150
in response to	149
the s subunit	149
confirmed cases of	148
the most common	148
coronavirus in dromedary	148
we found that	147
of the first	147
during the outbreak	146
clinical features of	146
protein of sars	145
from patients with	145
the lower respiratory	145
hospital outbreak of	145
with novel coronavirus	145
detected in the	145
there was no	145
of human coronavirus	144
the binding of	144
is a functional	144
the lungs of	144
to assess the	143
in the s	143
been reported in	142
spike protein of	142
patients with sars	142
infection prevention and	142
the formation of	142
the onset of	142
have also been	141
characteristics of cases	141
are associated with	141
because of the	141
human transmission of	141
to that of	141
as a result	140
part of the	140
identification of a	140
the end of	140
shown to be	139
outbreak in the	139
coronavirus associated with	139
closely related to	139
can be used	139
for treatment of	139
in the human	138
of this study	138
has not been	137
involved in the	137
of the outbreak	137
for the development	135
the upper respiratory	135
infection with mers	135
in the respiratory	134
and middle east	134
a mouse model	134
as previously described	134
the level of	134
close contact with	134
case of middle	133
cov infection and	132
the effects of	132
an outbreak of	132
dependent rna polymerase	131
clinical features and	130
syndrome coronavirus infections	130
be used to	130
a h n	129
an important role	129
in the early	129
number of cases	128
were detected in	128
systematic review and	128
a variety of	128
at the time	127
hospitalized patients with	127
transmission of sars	127
s protein of	126
vitro and in	126
immune response to	125
this study was	125
shortness of breath	125
caused by a	125
likely to be	125
activation of the	125
virus infection in	124
responsible for the	123
cases have been	123
of convalescent plasma	123
in the arabian	123
and evolution of	122
a patient with	122
were used to	121
of patients infected	121
are needed to	121
the cells were	121
transmission of the	121
saudi arabia and	121
model of mers	120
morbidity and mortality	120
for the emerging	120
included in the	120
antibodies against mers	120
respiratory tract infection	120
the kingdom of	120
there are no	120
the production of	120
infection in dromedary	120
binding domain of	119
of critically ill	119
as compared to	119
and treatment of	119
have shown that	119
of the most	118
receptor binding domain	118
and in vivo	117
of coronavirus disease	117
crystal structure of	117
the immune system	117
have been identified	117
large number of	117
as a potential	117
it is important	117
the immune response	116
important role in	116
in rhesus macaques	116
a result of	115
systematic review of	115
novel coronavirus pneumonia	115
that of the	115
at room temperature	115
is important to	115
during the mers	115
used in the	114
cytokines and chemokines	114
development of a	114
outbreak in korea	114
the identification of	114
used for the	114
mouse hepatitis virus	114
some of the	114
the virus was	113
the replication of	113
syndrome coronavirus disease	113
the ability to	113
cov in the	112
t cell responses	112
of s protein	112
in cell culture	112
observed in the	112
syndrome coronavirus spike	112
needs to be	111
infection control measures	111
of the human	111
of hospitalized patients	111
the virus to	111
there was a	110
pneumonia in wuhan	110
from dromedary camels	110
the basis of	110
a study of	110
of the host	109
that can be	109
a new coronavirus	109
there have been	109
of the infection	109
case of mers	109
the sars outbreak	109
the prevalence of	109
respiratory tract of	108
a role in	108
syndrome coronavirus and	107
mouse model of	107
the emerging human	107
the virus is	107
a review of	107
high levels of	107
dipeptidyl peptidase is	107
was observed in	107
in the future	106
coronavirus middle east	106
infectious bronchitis virus	106
for h at	106
nsp and nsp	106
in this review	106
and in the	106
the epidemiology of	106
associated with severe	106
mers coronavirus in	105
a case of	105
s and s	105
cells in the	105
severe respiratory disease	105
used as a	105
similar to the	105
of ebola virus	105
and public health	105
with severe covid	104
the authors declare	104
antiviral activity of	104
should be considered	104
on the basis	103
the innate immune	103
domain of the	103
incubation period of	103
in the upper	103
the novel human	103
emerging human coronavirus	103
infection in a	103
consistent with the	103
from the middle	102
infection in humans	102
bat coronavirus hku	102
onset of symptoms	102
patients with pneumonia	101
wang et al	101
acute lung injury	101
of influenza a	101
have been shown	101
in animal models	101
saudi arabia in	100
immune responses in	100
the virus and	100
human coronavirus oc	100
associated with acute	100
in the mers	100
virus in the	100
around the world	99
be associated with	99
fatality rate of	99
antibodies in dromedary	99
porcine epidemic diarrhea	99
peptidase is a	99
in the past	99
resulted in a	99
depending on the	99
been detected in	99
of the study	99
mice infected with	98
of a new	98
in contrast to	98
to the sars	98
have not been	98
human monoclonal antibody	98
patients in the	97
positive for mers	97
coronavirus in the	97
the potential for	97
and pathogenesis of	97
the ability of	97
the index case	97
of infectious diseases	97
is responsible for	97
members of the	96
of the covid	96
found in the	96
to the mers	96
coronavirus disease from	96
review of the	96
similar to that	96
n a l	96
the induction of	96
end of the	96
similar to those	96
in the first	95
with a high	95
retrospective cohort study	95
disease from saudi	95
spread of mers	95
no evidence of	95
caused by the	95
addition to the	95
a l p	95
to have a	95
p r e	95
the human population	95
j o u	94
shown in figure	94
respiratory disease in	94
p r o	94
response to the	94
considered to be	94
was used as	94
l p r	94
r n a	94
personal protective equipment	94
each of the	94
the index patient	94
u r n	94
compared with the	94
o u r	94
r o o	94
o o f	94
contact with the	93
may not be	93
that of sars	93
expression of the	93
of the severe	93
the united arab	93
the potential to	93
in the lung	93
were associated with	93
mechanism of action	93
a range of	92
genomic characterization of	92
severe respiratory illness	92
were observed in	92
prophylactic and therapeutic	92
the discovery of	92
li et al	92
shown in fig	92
neutralizing antibodies in	92
the effectiveness of	91
data not shown	91
the rate of	91
conflict of interest	91
the virus in	91
infection with middle	91
human coronavirus nl	91
a report of	91
of lopinavir ritonavir	91
the outbreak in	91
cov has been	91
modified vaccinia virus	91
serum samples from	91
review and meta	91
obtained from the	91
based on a	90
was performed using	90
the proportion of	90
in a study	90
evolution of the	90
to identify the	90
family cluster of	90
infected with the	90
that the virus	90
to reduce the	90
in the development	90
with respect to	90
coronavirus infections in	90
in the study	90
appears to be	90
of acute respiratory	90
in healthcare settings	90
human coronavirus e	89
by a novel	89
the beginning of	89
the occurrence of	89
for min at	89
role of the	89
clinical course and	89
camels in saudi	89
it is not	89
the n protein	89
the combination of	88
ebola virus disease	88
treatment of sars	88
isolated from a	88
used to treat	88
analysis of a	88
innate immune responses	88
in the spike	88
than that of	88
characterization of the	88
cellular immune responses	87
of the cases	87
risk of mers	87
type i ifn	87
first case of	87
approved by the	87
also known as	87
viral load in	87
as described previously	87
the surface of	87
in accordance with	87
hepatitis c virus	87
efficacy and safety	87
vaccinia virus ankara	87
increase in the	87
of human coronaviruses	86
isolation and characterization	86
direct contact with	86
was reported in	86
contact with camels	86
outbreak of mers	86
chen et al	86
have been developed	86
health care facilities	86
of type i	86
in the present	86
the activation of	86
found that the	85
implications for the	85
of the two	85
the patient was	85
a series of	85
to those of	85
between the two	85
transcription polymerase chain	85
can also be	85
human immunodeficiency virus	85
days after the	85
a large number	84
to investigate the	84
binding of the	84
been associated with	84
in mers patients	84
middle east and	84
b and ribavirin	84
the ace receptor	84
years of age	83
contribute to the	83
open reading frame	83
of influenza virus	83
a lack of	83
against middle east	83
total number of	83
changes in the	83
of the world	83
of the genome	83
the mechanism of	82
in the lower	82
reported to be	82
of the immune	82
of transmission of	82
the inhibition of	82
the receptor binding	82
were infected with	82
the h n	82
angiotensin converting enzyme	82
supported by the	82
could not be	82
viral rna was	82
was added to	82
the host immune	82
epidemic diarrhea virus	82
all of the	81
genome sequence of	81
acute respiratory infections	81
cases and deaths	81
was used for	81
was supported by	81
in the kingdom	81
to understand the	81
neutralizing antibodies against	81
is consistent with	81
cases in the	81
are known to	81
isolated from the	81
be used for	81
is essential for	81
it is also	81
of the rbd	80
was isolated from	80
mortality rate of	80
cov infected patients	80
at the same	80
to control the	80
the activity of	80
wide range of	80
to the virus	80
tested positive for	80
for the prevention	80
of this virus	80
of sars and	80
were reported in	80
is based on	80
is required for	80
present in the	80
at the end	79
influenza a h	79
any of the	79
there is an	79
mediated by the	79
the entry of	79
the management of	79
study showed that	79
differences in the	79
with or without	79
treatment of severe	79
a history of	79
avian influenza a	79
orf a and	79
west nile virus	78
the first case	78
is one of	78
are shown in	78
insights into the	78
for the first	78
and safety of	78
of the manuscript	78
shown in table	78
is an important	78
in severe acute	78
the extent of	78
transmission of middle	78
into host cells	78
a retrospective cohort	78
increased risk of	78
human infection with	78
be due to	77
the origin of	77
to prevent the	77
it can be	77
host cell entry	77
the viral genome	77
are likely to	77
novel coronavirus infection	77
in our study	77
similar to sars	77
those of the	77
derived from the	77
of confirmed cases	77
a family cluster	77
added to the	76
contributed to the	76
has been used	76
of infection with	76
of the epidemic	76
immune response in	76
the control of	76
results showed that	76
the prevention of	76
in health care	76
as described above	76
the relationship between	76
in humans and	75
diagnosis and treatment	75
treatment of mers	75
at least one	75
a novel human	75
host immune response	75
of infected patients	75
in the sars	75
during the sars	75
for detection of	74
in a single	74
was shown to	74
cluster of middle	74
the duration of	74
and cd t	74
up to days	74
cases of covid	74
immune responses to	74
when compared to	74
mouse model for	74
high prevalence of	74
dromedary camels and	74
a wide range	74
features of patients	74
generation of a	74
from a patient	74
of a case	74
disease in humans	74
cov infection was	74
but not in	74
of neutralizing antibodies	74
cells infected with	73
h n virus	73
in relation to	73
that there is	73
the total number	73
distress syndrome in	72
the spike glycoprotein	72
against mers coronavirus	72
coronavirus infection and	72
to health care	72
epidemiological and clinical	72
viral rna in	72
the common cold	72
type i and	72
can be found	72
it is possible	72
cov m protein	72
for severe acute	72
it should be	72
therapeutic efficacy of	72
with regard to	72
detection of sars	72
infected with novel	72
which is a	72
appear to be	72
course of the	72
factors associated with	72
study middle east	72
mers and sars	72
contact with a	71
was carried out	71
thought to be	71
the intensive care	71
acute respiratory illness	71
studies have shown	71
suggest that the	71
for the detection	71
results suggest that	71
is the most	71
the availability of	71
of these viruses	71
for the sars	71
have been used	71
may also be	71
s protein is	71
an animal model	71
an overview of	70
time reverse transcription	70
of an outbreak	70
and epidemiology of	70
of mers in	70
the amount of	70
the host cells	70
the probability of	70
in the number	70
in which the	70
in comparison to	70
a link to	70
with the mers	70
the addition of	70
pregnant women with	70
features of the	70
we did not	70
with a new	69
has been found	69
adjuvanted rbd vaccine	69
has been demonstrated	69
in the current	69
were obtained from	69
serum antibodies in	69
in critically ill	69
caused by sars	69
yet to be	69
binding to the	69
admitted to the	69
of mers and	69
it is a	69
novel human betacoronavirus	69
is similar to	69
of public health	69
evidence for camel	69
the source of	68
that have been	68
with lopinavir ritonavir	68
may be a	68
cell entry of	68
activity of the	68
cases were reported	68
the public health	68
which can be	68
comparative serological study	68
to determine whether	68
to better understand	68
t cells in	68
cd and cd	68
seems to be	67
in the hospital	67
course and outcomes	67
inflammatory cytokines and	67
been found to	67
with mers coronavirus	67
entry into the	67
suggests that the	67
and development of	67
our understanding of	67
in the world	67
randomized clinical trial	67
aspects of the	67
diagnosis of mers	67
in sars patients	67
to severe acute	67
the university of	67
the same time	67
viral shedding and	67
were used as	67
patients who were	67
a public health	67
replication in the	67
for the mers	67
with coronavirus disease	67
results of the	66
suggesting that the	66
in contact with	66
randomized controlled trial	66
reported in the	66
infect dis doi	66
well as in	66
outbreak of severe	66
viral replication and	66
a comparative serological	66
on the surface	66
no conflict of	66
coronavirus in saudi	66
the first time	66
the most important	66
information on the	66
influenza a viruses	66
in middle east	66
newly discovered coronavirus	66
a retrospective study	66
cases of infection	66
airway epithelial cells	66
case of sars	66
this article is	66
cause of severe	66
respiratory tract and	65
in complex with	65
human dipeptidyl peptidase	65
the case fatality	65
cov m pro	65
extracorporeal membrane oxygenation	65
and can be	65
the general population	65
a group of	65
zhou et al	65
the control group	65
and lower respiratory	65
the potential of	65
outcomes of critically	65
the s domain	65
and orf b	65
play an important	65
was defined as	65
are required to	65
of infectious virus	64
a case report	64
compared to those	64
with the middle	64
data suggest that	64
with the novel	64
during the first	64
data from the	64
region of the	64
acute respiratory infection	64
the study of	64
is needed to	64
is known to	64
the diagnosis of	64
into the host	64
in upper respiratory	64
coronavirus in wuhan	64
the levels of	64
in the host	64
sequence of the	64
and risk factors	64
is able to	64
is likely to	64
viral replication in	64
the cell surface	64
belong to the	64
viruses such as	63
conflicts of interest	63
implications for virus	63
an outbreak investigation	63
pneumonia in china	63
and control of	63
outcomes of patients	63
antiviral activity against	63
to be effective	63
suggested that the	63
were able to	63
eastern respiratory syndrome	63
been used to	63
the ministry of	63
samples were collected	63
was able to	63
saudi ministry of	63
bronchial epithelial cells	63
after symptom onset	63
in vitro studies	63
middle eastern respiratory	63
protein of the	63
in clinical trials	63
to the human	63
the evolution of	63
in the viral	63
the lungs and	63
in vero e	63
were collected from	63
cells of the	62
yang et al	62
is the first	62
of novel human	62
study of the	62
located in the	62
and it is	62
to study the	62
for critically ill	62
coronavirus neutralising serum	62
the united kingdom	62
found to have	62
the rbd of	62
the quality of	62
linked to the	62
the outcome of	62
the coronavirus disease	62
to have been	62
neutralising serum antibodies	62
the structure of	62
was identified as	62
to the middle	62
coronavirus outbreak in	62
and transmission of	62
s protein and	62
convalescent plasma therapy	62
syndrome coronavirus neutralising	62
rna was detected	62
serum samples were	62
early stages of	62
spike protein and	62
efficacy of remdesivir	62
cov infection is	62
and receptor binding	62
institutional review board	61
and h n	61
binds to the	61
to middle east	61
detection of a	61
of two cases	61
did not have	61
the characteristics of	61
protein is a	61
of the total	61
authors declare no	61
due to its	61
be able to	61
coronavirus spike glycoprotein	61
no competing interests	61
who did not	61
be used as	61
this work was	61
cov replication in	61
due to a	61
acute respiratory disease	61
in a mouse	61
upper and lower	61
animal models of	61
the sars epidemic	61
there has been	61
used in this	60
of health and	60
of pregnant women	60
in a recent	60
linked immunosorbent assay	60
ace and tmprss	60
the cytokine storm	60
reported that the	60
prior to the	60
is mediated by	60
authors declare that	60
and has been	60
amino acid residues	60
assessment of the	60
parts of the	60
and south korea	60
respiratory syndrome outbreak	60
is necessary to	60
zhao et al	60
human monoclonal antibodies	60
in southern china	60
number of mers	60
to be more	60
of h n	60
safety and efficacy	60
diffuse alveolar damage	60
as a possible	60
the distribution of	60
regions of the	59
during the course	59
rift valley fever	59
an increase in	59
assiri et al	59
t cells and	59
viruses in bats	59
in mice and	59
all rights reserved	59
to develop a	59
cd t cell	59
neutralizing monoclonal antibodies	59
were tested for	59
domain of mers	59
mers and covid	59
coronavirus from patients	59
central nervous system	59
of proinflammatory cytokines	59
detection of mers	59
is important for	59
syndrome coronavirus middle	59
a newly discovered	59
be explained by	59
the s glycoprotein	59
the interaction between	59
novel coronavirus disease	58
patients admitted to	58
phylogenetic analysis of	58
symptoms such as	58
referred to as	58
would like to	58
in pregnant women	58
were treated with	58
followed by a	58
of the current	58
control of the	58
of the receptor	58
there were no	58
data on the	58
the human respiratory	58
human respiratory tract	58
research and development	58
indicated that the	58
the early stage	58
evidence of mers	58
known to be	58
innate and adaptive	58
characteristics of the	58
were positive for	58
h n pdm	58
of the new	58
epidemiology of novel	58
countries in the	58
of nosocomial transmission	58
such as sars	58
patients with coronavirus	58
in the community	58
of dromedary camels	58
related to mers	58
public health emergency	58
occurred in the	58
led to the	58
results indicate that	58
for at least	58
in vero cells	58
ranging from to	58
to respiratory failure	58
replication and pathogenesis	57
patients with confirmed	57
and cellular immune	57
could be used	57
the common marmoset	57
may contribute to	57
detection of the	57
of the infected	57
can lead to	57
compared to sars	57
human betacoronavirus c	57
revealed that the	57
to inhibit the	57
for mers coronavirus	57
feline infectious peritonitis	57
syndrome in humans	57
to the host	57
were more likely	57
outbreak in jeddah	57
is shown in	57
structure of mers	57
is caused by	57
were included in	57
have been described	57
of the pandemic	57
a pneumonia outbreak	57
entry into host	57
of a newly	57
human middle east	57
were incubated with	57
have been found	57
reported to the	57
spike glycoprotein of	57
leading to the	57
t cells were	57
for the presence	56
the percentage of	56
is possible that	56
in the ed	56
the mortality rate	56
outbreak associated with	56
kim et al	56
are involved in	56
in the last	56
coronavirus disease in	56
pathogenesis of sars	56
identified in the	56
n influenza virus	56
the copyright holder	56
coronavirus study group	56
coronavirus in bats	56
early stage of	56
the new coronavirus	56
was found in	56
th and th	56
confirmed cases and	56
potent neutralization of	56
betacoronavirus c emc	56
out of the	56
of mers cases	56
coronavirus in patients	56
structural basis for	56
a previous study	56
in a patient	56
basic reproduction number	55
center for disease	55
exposure to the	55
were used for	55
as part of	55
outside of the	55
in some cases	55
human airway epithelial	55
for the virus	55
for virus origins	55
infection and disease	55
more than of	55
is that the	55
infections in humans	55
mers coronavirus infection	55
susceptible to mers	55
of the studies	55
play a role	55
resulting in a	55
higher than that	55
has been observed	55
in line with	55
severe middle east	55
the existence of	55
infection control and	55
infection and the	55
of action of	55
virus origins and	55
tract infection in	55
sars coronavirus infection	55
are similar to	55
cells were washed	55
influenza virus infection	55
also been reported	54
high mortality rate	54
and incubated at	54
more than one	54
in case of	54
mild to moderate	54
c bl mice	54
the virus has	54
the coronavirus study	54
human to human	54
nature of the	54
of the protein	54
should not be	54
samples from the	54
hepatitis b virus	54
potent inhibitor of	54
treatment of patients	54
indicate that the	54
open reading frames	54
was used in	54
to display the	54
origins and receptor	54
may have been	54
during the early	54
in dromedary camel	54
the viral spike	54
were identified as	54
the antiviral activity	54
laboratory confirmation of	54
of the patient	54
of the three	54
remains to be	53
by the world	53
are responsible for	53
park et al	53
used as the	53
republic of china	53
to public health	53
neutralizing antibody titers	53
and severe acute	53
the causative agent	53
replication of sars	53
member of the	53
impact of the	53
emergence of a	53
mode of transmission	53
granted medrxiv a	53
to detect the	53
who has granted	53
severity of the	53
this is the	53
the study was	53
were found in	53
probable bat origin	53
been observed in	53
other respiratory viruses	53
has granted medrxiv	53
the s and	53
the preprint in	53
in balb c	53
pneumonia outbreak associated	53
of a mers	53
medrxiv a license	53
respiratory syndrome and	53
a license to	53
coronavirus of probable	53
treatment of middle	53
syndrome coronavirus replication	53
transmissible gastroenteritis virus	53
display the preprint	53
license to display	53
of probable bat	53
and efficacy of	53
impact on the	53
link to health	53
cov infection of	53
characterisation and epidemiology	53
new coronavirus of	53
not yet been	53
discovered coronavirus associated	53
the generation of	53
the efficacy and	53
in the transmission	53
animal model for	52
protein of mers	52
coronavirus replication in	52
combination of interferon	52
included in this	52
cases of sars	52
chinese horseshoe bats	52
disease caused by	52
the genome of	52
dromedary camels are	52
of inflammatory cytokines	52
estimated to be	52
associated with increased	52
domain complexed with	52
nonhuman primate model	52
there are many	52
viral entry into	52
activity against sars	52
syndrome coronavirus as	52
cov and other	52
further studies are	52
clinical management of	52
that they have	52
host immune responses	52
to infection with	52
associated with mers	52
human and animal	52
coronaviruses in the	52
the concentration of	52
influenza a and	52
these results suggest	52
genomic characterisation and	52
high risk of	52
has been suggested	52
could be a	52
a single patient	52
a single dose	52
innate antiviral response	52
patients with novel	51
model for middle	51
human coronavirus infections	51
are more likely	51
this is a	51
better understanding of	51
the gene source	51
diseases such as	51
is a novel	51
as the gene	51
work was supported	51
molecular basis of	51
of the same	51
comparative analysis of	51
novel coronavirus associated	51
was reported to	51
after the onset	51
and prevention of	51
summarized in table	51
of the four	51
study was conducted	51
and innate immune	51
national institute of	51
the viral rna	51
of the risk	51
with severe disease	51
infection of the	51
and incubated for	51
cov and the	51
the active site	51
were performed using	51
pneumonia in the	51
presence of mers	51
which may be	51
serve as a	51
this suggests that	51
by using the	51
cases of novel	51
source of infection	51
that the mers	51
of the national	51
of infection in	51
belongs to the	51
one or more	51
disease in china	51
has been described	51
emergence of mers	51
to the world	51
identified as the	51
and management of	51
camels middle east	51
efficacy of a	51
of exposure to	51
mutations in the	51
and control measures	50
and use of	50
in the healthcare	50
risk factor for	50
severe disease and	50
due to their	50
respiratory infections in	50
a set of	50
a broad spectrum	50
s subunit of	50
coronavirus spike proteins	50
coronavirus pneumonia in	50
better understand the	50
from the first	50
to improve the	50
is thought to	50
have been detected	50
the most recent	50
related to sars	50
analysis was performed	50
case of the	50
tumor necrosis factor	50
therapeutic options for	50
lead to the	50
and the middle	50
binding domain complexed	50
clinical and laboratory	50
an observational study	50
and the other	50
number of patients	50
the early stages	50
cells were incubated	50
with severe respiratory	50
correlated with the	50
are the most	50
than in the	50
be noted that	50
global public health	50
to treat covid	50
tertiary care hospital	50
were carried out	50
an analysis of	50
efficacy of the	50
origin of sars	50
primate model of	50
with the highest	50
gene source of	49
the s gene	49
syndrome coronavirus transmission	49
on the th	49
fetal bovine serum	49
respiratory tract samples	49
the basic reproduction	49
and virological analysis	49
spike protein in	49
that it is	49
the cause of	49
epithelial cells of	49
by the who	49
the analysis of	49
the emergency room	49
of cases in	49
in a large	49
and dromedary camels	49
likely to have	49
demonstrated that the	49
the introduction of	49
of symptom onset	49
of infection and	49
stage of the	49
receptor for sars	49
with the sars	49
patients who had	49
the e protein	49
is also a	49
in the blood	49
replication of the	49
their ability to	49
humoral and cellular	49
lethal pneumonia in	49
inhibition of the	49
cov is a	49
clinical signs of	49
which was not	49
two cases of	49
response to sars	49
identification of the	49
resulted in the	49
were shown to	49
by the viral	49
in jeddah and	49
but it is	49
not associated with	49
origin of the	48
science and technology	48
virological analysis of	48
lu et al	48
was identified in	48
a potent inhibitor	48
as a novel	48
korea middle east	48
was obtained from	48
in comparison with	48
features and virological	48
is a potent	48
over the past	48
and infection control	48
which has been	48
the virus can	48
in another study	48
in agreement with	48
the risk factors	48
contact with infected	48
not result in	48
to infect humans	48
be related to	48
viral shedding in	48
the current study	48
viral loads in	48
a cluster of	48
it would be	48
and therapeutic options	48
exposed to the	48
in patients infected	48
studies showed that	48
patients with the	48
been identified in	48
the incidence of	48
at high risk	48
comparison of the	48
use of corticosteroids	48
version of the	48
pandemic influenza a	48
is a major	48
acts as a	48
in more than	48
in the common	48
by using a	48
the viral replication	47
be found in	47
infl uenza a	47
in the environment	47
to the viral	47
shedding of mers	47
entry of the	47
the recently emerged	47
to confirm the	47
outbreaks of middle	47
by the novel	47
related to a	47
in a nonhuman	47
outbreak of sars	47
of cases and	47
for use in	47
and avian coronaviruses	47
a nonhuman primate	47
b and c	47
defined as the	47
novel coronavirus outbreak	47
was performed in	47
for up to	47
prevalence of mers	47
of rhesus macaques	47
was performed by	47
human coronavirus emc	47
cov have been	47
findings suggest that	47
as the most	47
an inhibitor of	47
and chemokines in	47
patients with acute	47
human and camel	47
protective efficacy of	47
coronaviruses as the	47
innate immune system	47
the first imported	47
imported case of	47
is characterized by	47
natural killer cells	47
to the control	47
illness caused by	47
i and ii	47
is no evidence	47
camels in the	47
did not show	47
was based on	47
of infectious disease	47
syndrome coronavirus by	47
that could be	46
rhesus macaque model	46
at least two	46
remdesivir and chloroquine	46
in household contacts	46
complete genome sequence	46
the plasma membrane	46
in this context	46
the regulation of	46
that has been	46
a reduction in	46
after exposure to	46
of t cells	46
national institutes of	46
has been identified	46
an update on	46
preprint in perpetuity	46
basis for the	46
in the icu	46
saudi arabia mers	46
antibody against mers	46
and shortness of	46
preparedness and response	46
use of a	46
for viral replication	46
in vitro antiviral	46
public health and	46
syndrome in hong	46
in the control	46
in the brain	46
declare that they	46
the crystal structure	46
the safety and	46
compared to other	46
phase of the	46
of the data	46
to be used	46
a mortality rate	46
may lead to	46
lower than that	46
a and orf	46
bind to the	46
was confirmed by	46
korea centers for	46
they have no	46
the frequency of	46
of viral replication	46
h n and	46
clinical trials are	46
the saudi ministry	46
transmission to humans	46
outcome of mers	46
taxonomy of viruses	46
for this study	46
a subset of	46
and the united	46
mice treated with	46
host response to	46
admission to the	46
such as mers	46
during the covid	46
sars coronavirus spike	46
novel middle east	46
among healthcare workers	46
to the same	46
can result in	46
studies on the	46
negative for mers	46
by the national	46
in the field	45
and mortality in	45
sars in the	45
implications for pathogenesis	45
been reported that	45
those who were	45
the application of	45
chan et al	45
exposed to mers	45
epithelial cells and	45
of the animals	45
coronavirus as a	45
and interferon beta	45
who had been	45
are susceptible to	45
higher risk of	45
proteins of sars	45
identified as a	45
the design of	45
the most promising	45
reported to have	45
in close contact	45
the involvement of	45
number of infected	45
illness in humans	45
was first reported	45
and the number	45
human coronavirus by	45
cov infections in	45
copyright holder for	45
of a mouse	45
of the literature	45
the process of	45
traditional chinese medicine	45
to be associated	45
high level of	45
with that of	45
humans and animals	45
lessons from the	45
different types of	45
should be noted	45
are able to	45
like protease of	45
a case fatality	45
and severity of	45
syndrome middle east	45
public health authorities	45
liu et al	45
is blocked by	45
a dromedary camel	45
dromedary camels middle	45
expression levels of	44
to saudi arabia	44
from sars to	44
is related to	44
virus was detected	44
half of the	44
tmprss and is	44
coronavirus nucleocapsid protein	44
accordance with the	44
the sars and	44
as of june	44
infection in rhesus	44
exposure to infected	44
after the first	44
in the nasal	44
inhibitors of the	44
stages of the	44
discovery of a	44
and postexposure efficacy	44
entry depends on	44
care and use	44
a fatal case	44
holder for this	44
onset of illness	44
effectively inhibit the	44
an urgent need	44
a better understanding	44
national health commission	44
the age of	44
broad range of	44
the interaction of	44
syndrome coronavirus outbreak	44
the outbreak was	44
fatal case of	44
days prior to	44
attributed to the	44
blocked by a	44
respiratory syndrome middle	44
of respiratory viruses	44
animal models for	44
the result of	44
of infection control	44
with the virus	44
outbreaks in the	44
with the same	44
is critical for	44
to increase the	43
in hospitalized patients	43
transmission dynamics in	43
by a clinically	43
in infected cells	43
on ace and	43
rapid generation of	43
the rhesus macaque	43
and pp ab	43
syndrome coronavirus papain	43
viral load and	43
risk of transmission	43
for public health	43
in severe covid	43
institutes of health	43
of sars patients	43
is required to	43
outbreaks of mers	43
state of knowledge	43
of human middle	43
and clinical features	43
proinflammatory cytokines and	43
was conducted in	43
and tmprss and	43
inhibition of sars	43
cell entry depends	43
transgenic mouse model	43
the orf a	43
the amino acid	43
have been associated	43
infected rhesus macaques	43
cells were then	43
amino acid sequence	43
previous studies have	43
are essential for	43
several studies have	43
factors such as	43
assays for laboratory	43
humoral immune response	43
respiratory illness caused	43
as in the	43
outbreak in china	43
evaluation of the	43
is difficult to	43
of the e	43
infectious virus was	43
of severe covid	43
food and drug	43
shown that the	43
that the sars	43
spread of covid	43
be infected with	43
studies are needed	43
to the icu	43
interaction between the	43
many of the	43
the virus from	43
and is blocked	43
first reported in	43
in this article	43
a clinically proven	43
importance of the	43
patients with respiratory	43
the international committee	43
as high as	43
have to be	43
wit et al	43
no significant difference	43
and acute respiratory	43
the response to	43
of the cell	43
thermo fisher scientific	43
and interferon therapy	43
wu et al	43
activity against mers	43
depends on ace	43
de wit et	43
during an outbreak	43
and that the	43
structure of sars	43
transmission of covid	43
elevated levels of	43
small number of	43
of remdesivir and	43
alveolar epithelial cells	43
prevention and treatment	43
in the literature	43
and approved the	43
and infectious diseases	43
been identified as	43
and did not	42
s proteins of	42
of the following	42
coronavirus by real	42
use of convalescent	42
of the respiratory	42
in a hospital	42
infection control practices	42
the phylogenetic tree	42
were exposed to	42
study of patients	42
into target cells	42
in china and	42
has been detected	42
adaptive immune responses	42
of mers patients	42
virus has been	42
or absence of	42
of the c	42
caused by mers	42
the progression of	42
it is unclear	42
signs of disease	42
postexposure efficacy of	42
the timing of	42
significantly associated with	42
and mers coronaviruses	42
susceptibility to the	42
proven protease inhibitor	42
disease prevention and	42
coronavirus isolated from	42
showed that mers	42
pandemic h n	42
not detected in	42
is involved in	42
emergence of the	42
associated with human	42
treatment with interferon	42
hr and hr	42
from the mers	42
associated outbreak of	42
the evaluation of	42
virus entry and	42
viral rna synthesis	42
has been proposed	42
spike protein gene	42
from bats to	42
in vitro activity	42
plays an important	42
the in vitro	42
of the fusion	42
betacoronavirus lineage c	42
a randomized controlled	42
coronavirus antibodies in	42
respiratory viral infections	42
with confirmed mers	42
dependent on the	42
to infected camels	42
is supported by	42
expressed in the	42
based on these	42
was admitted to	42
and identification of	42
and accessory proteins	42
respiratory tract specimens	42
focused on the	42
the centers for	42
for laboratory confirmation	42
and interferon alfa	42
as a treatment	42
acute renal failure	42
safe and effective	42
for severe middle	42
like virus in	42
infection during pregnancy	42
corman et al	42
infection with a	42
were admitted to	42
for the study	42
case of novel	41
clinically proven protease	41
clinical characteristics and	41
animal model of	41
was determined by	41
the possibility that	41
for vaccine development	41
coronavirus in a	41
there are several	41
infection in vitro	41
risk of infection	41
context of the	41
control study of	41
with a combination	41
increase the risk	41
associated with an	41
been found in	41
on taxonomy of	41
were negative for	41
for more than	41
study was to	41
neutralizing antibodies and	41
replication of middle	41
presence or absence	41
results in the	41
the findings of	41
week of illness	41
camels in egypt	41
human coronavirus mers	41
along with the	41
the pattern of	41
in the emergency	41
explained by the	41
the past years	41
in the region	41
seem to be	41
arabian peninsula and	41
transmission in the	41
international committee on	41
serine protease tmprss	41
were transfected with	41
receptor for mers	41
low levels of	41
is expected to	41
on the same	41
camels to humans	41
of the innate	41
respiratory tract disease	41
announcement of the	41
emerged novel coronavirus	41
of secondary cases	41
of the clinical	41
within days of	41
the early phase	41
of a family	41
tested for mers	41
in any of	41
as a receptor	41
majority of the	41
a key role	41
from animals to	41
safety and immunogenicity	41
on the use	41
were determined by	41
in the pathogenesis	41
risk of death	41
syndrome coronavirus vaccine	41
associated with high	41
and implications for	41
host innate immune	41
committee on taxonomy	41
em structure of	41
the species barrier	41
were identified in	41
from to days	40
as a vaccine	40
of patients who	40
treatment with lopinavir	40
total of patients	40
combination of lopinavir	40
as one of	40
a member of	40
laboratory testing for	40
cov or mers	40
be detected in	40
of human infection	40
a median of	40
a and pp	40
on the epidemiology	40
using the same	40
to the lack	40
and other respiratory	40
virus replication and	40
transmembrane serine protease	40
asymptomatic or mild	40
a decrease in	40
weeks after the	40
and chloroquine effectively	40
to be further	40
fact that the	40
and immunogenicity of	40
the first mers	40
viral diagnosis of	40
acute kidney injury	40
of sars in	40
a new human	40
presence of the	40
infectious disease response	40
in this regard	40
limited number of	40
number of confirmed	40
the viral load	40
of patients in	40
responses to sars	40
of knowledge and	40
the likelihood of	40
with the exception	40
and clinical description	40
emerging infectious disease	40
been reported from	40
patients who received	40
in rhesus monkeys	40
inhibitory activity of	40
and adaptive immune	40
is due to	40
the need to	40
recently emerged novel	40
immune responses and	40
type i ifns	40
analysis based on	40
inhibit the recently	40
sars to mers	40
of the korean	40
the site of	40
cov in upper	40
believed to be	40
drug discovery and	40
to the who	40
and drug administration	40
of avian influenza	40
of mouse hepatitis	40
distribution of the	40
were the most	40
the human coronavirus	40
pp a and	40
a study on	40
that in the	40
have the potential	40
the healthcare setting	40
chloroquine effectively inhibit	40
recent insights into	40
difference in the	40
as a model	40
responses to the	40
were conducted in	40
are found in	40
to analyze the	40
animals and humans	40
a prospective study	40
diagnosis of two	40
in the rbd	40
the family coronaviridae	40
and viral diagnosis	39
reported to who	39
of severe respiratory	39
a receptor for	39
dynamics of the	39
the influence of	39
of the index	39
airborne transmission of	39
renal replacement therapy	39
of a single	39
syndrome in the	39
that they are	39
has shown that	39
south korea and	39
the development and	39
development of an	39
with severe mers	39
highest number of	39
an infectious disease	39
neutralizing antibody responses	39
respiratory syndrome virus	39
early phase of	39
characteristics of hospitalized	39
followed by the	39
mortality in patients	39
respiratory illness in	39
model for the	39
responses to mers	39
antibodies against the	39
signs and symptoms	39
disease in the	39
to replicate in	39
been exposed to	39
therapy in patients	39
origin and evolution	39
transient lower respiratory	39
syndrome coronavirus a	39
features and viral	39
of disease severity	39
antibodies were detected	39
in the management	39
is known about	39
cell responses to	39
to compare the	39
of the vaccine	39
are in the	39
cluster of pneumonia	39
report of nosocomial	39
and shedding of	39
characteristics of mers	39
murine hepatitis virus	39
and viral load	39
cov in vitro	39
described in the	39
outcome in mers	39
huang et al	39
replication and shedding	39
have been published	39
cell responses in	39
is essential to	39
was the most	39
severity of disease	39
indicates that the	39
infections have been	39
enzyme is a	39
of viral shedding	39
cov and its	39
of at least	39
broad spectrum of	39
the function of	39
for novel coronavirus	39
cells were transfected	39
hospital in saudi	39
the emerging novel	39
host cell receptor	39
with those of	39
and phylogenetic analysis	39
the form of	39
rna was extracted	39
to the high	39
of these two	39
of the international	39
coronaviruses in dromedary	39
cells were infected	39
carried out in	39
stranded rna viruses	39
of healthcare workers	39
as described in	39
with disease severity	39
it may be	39
in the usa	39
terms of the	39
a high prevalence	38
influenza h n	38
model of common	38
may be the	38
health care settings	38
spike protein is	38
the magnitude of	38
it was found	38
the differences in	38
that may be	38
walls et al	38
provided by the	38
known to cause	38
study of a	38
and those with	38
a type i	38
were reported to	38
at the beginning	38
to interact with	38
falzarano et al	38
may result in	38
the release of	38
replication in cell	38
be used in	38
it was also	38
mers coronavirus after	38
to protect against	38
period of time	38
epidemiology of mers	38
isolation of mers	38
coronavirus in household	38
in lung tissue	38
seen in the	38
coronaviruses in bats	38
of coronavirus in	38
reported in saudi	38
have been proposed	38
for the diagnosis	38
the disease and	38
inhibitors of middle	38
are summarized in	38
pathogenesis of coronaviruses	38
model for mers	38
lopinavir ritonavir and	38
the natural reservoir	38
development of vaccines	38
was first identified	38
as severe acute	38
lessons learned from	38
host cell membrane	38
in recent years	38
in human cells	38
has been a	38
beginning of the	38
human cases of	38
s protein to	38
analysis showed that	38
at h post	38
lopinavir ritonavir in	38
the s proteins	38
of common marmoset	38
coronavirus after exposure	38
of these patients	38
lopinavir ritonavir or	38
in west africa	38
in vivo studies	38
viral respiratory infections	38
led to a	38
of coronaviruses in	38
discovery and therapeutic	38
is the author	38
the author funder	38
replication in vitro	38
confirmation of novel	38
cases reported in	38
of clinical trials	38
significant difference in	38
the disease in	38
causative agent of	38
a safe and	38
mice immunized with	38
an intermediate host	38
protective immunity against	38
with at least	38
was first isolated	38
disease severity in	38
the infection of	38
the two groups	38
from the same	38
first identified in	38
converting enzyme is	38
interaction with the	38
cov s glycoprotein	38
but did not	38
response in patients	38
pathogenesis of mers	38
epidemic and zoonotic	38
avian influenza virus	38
animals to humans	38
in light of	38
of a large	37
geographic distribution of	37
or in combination	37
titers in the	37
with sars and	37
like to thank	37
their role in	37
and data gaps	37
was not detected	37
which in turn	37
have demonstrated that	37
in patients who	37
into emerging coronaviruses	37
incubated for h	37
syndrome coronavirus receptor	37
for this preprint	37
in a small	37
of the drug	37
expression of ace	37
studies of sars	37
i and mda	37
gaps of middle	37
a statistically significant	37
from a dromedary	37
data gaps of	37
incubation period was	37
higher than the	37
is protected by	37
insights into emerging	37
antibodies to the	37
the type of	37
coronavirus envelope protein	37
of viral infection	37
sensitivity and specificity	37
by severe acute	37
memish et al	37
interfere with the	37
to examine the	37
risk factors and	37
antibody response in	37
is an urgent	37
zhang et al	37
specific cd t	37
at increased risk	37
expected to be	37
combination with ribavirin	37
knowledge and data	37
was approved by	37
is closely related	37
to estimate the	37
affected by the	37
inhibition of mers	37
syndrome coronavirus antibodies	37
improves outcome in	37
ritonavir or interferon	37
and saudi arabia	37
and the risk	37
t cell response	37
cov neutralizing antibodies	37
of a bat	37
ribavirin improves outcome	37
the purpose of	37
to determine if	37
difference between the	37
and ribavirin improves	37
be the most	37
been used in	37
more susceptible to	37
vesicular stomatitis virus	37
infection of human	37
improves outcome of	37
a role for	37
subunit of the	37
a for severe	37
a confirmed case	37
the value of	37
the creative commons	37
to block the	37
of mechanical ventilation	37
recombination of mers	37
to human transmission	37
of vertical transmission	37
was performed on	37
model of middle	37
can be transmitted	37
infected pneumonia in	37
to address the	36
by a combination	36
to that in	36
cov spike glycoprotein	36
we used the	36
rna in the	36
the aim of	36
the prevention and	36
epidemiological characteristics of	36
form of the	36
had contact with	36
a comparison of	36
respiratory failure and	36
the plates were	36
to form a	36
with respiratory symptoms	36
studies have demonstrated	36
and human coronavirus	36
inhibitor of sars	36
multiple sequence alignment	36
and other coronaviruses	36
room temperature for	36
contrast to the	36
on the cell	36
patients with a	36
in view of	36
a model for	36
use of the	36
protected by copyright	36
with the use	36
it has also	36
kindly provided by	36
and its receptor	36
transmission has been	36
article is protected	36
entry of mers	36
in the cytoplasm	36
macaque model of	36
infections caused by	36
of a coronavirus	36
less likely to	36
in the form	36
the novel middle	36
syndrome corona virus	36
might have been	36
the national institute	36
in chinese horseshoe	36
can be detected	36
from the arabian	36
compared to that	36
shown to have	36
for sars coronavirus	36
to the rbd	36
have occurred in	36
the numbers of	36
focus on the	36
very similar to	36
was performed to	36
of a patient	36
study on the	36
be attributed to	36
disease outbreak news	36
high case fatality	36
patients treated with	36
and found that	36
analyses were performed	36
with a single	36
depends on the	36
and orf a	36
first imported case	36
public health response	36
to bind to	36
it is necessary	36
which is the	36
cov antibodies in	36
by the virus	36
of a fatal	36
for viral entry	36
the feasibility of	36
the results showed	36
some of these	36
a patient who	36
in a dose	36
of the population	36
was found that	36
effect of the	36
distribution of mers	36
as long as	36
b improves outcome	36
may have a	36
for the middle	36
and n genes	36
this study were	36
higher levels of	36
clinical manifestations of	36
a comparative study	36
phase i clinical	36
and more than	36
the dynamics of	36
zaki et al	36
respiratory symptoms and	36
the exception of	36