Distant Reader - keyword-rbd-cord

Introduction

This is a Distant Reader "study carrel", a set of structured data intended to help the student, researcher, or scholar use & understand a corpus.

This study carrel was created on 2021-05-25 by Eric Morgan <emorgan@nd.edu>. The carrel was created using the Distant Reader cord process, and the input was the result of a query applied to a local mirror of CORD, a data set of scholarly articles on the topic of COVID-19. The actual query was: keywords:rbd. The results of this query were saved in a cache and transformed into a set of plain text files. All of the analysis -- "reading" -- has been done against these plain text files. For example, a short narrative report has been created. This Web page is a more verbose version of that report.

All study carrels are self-contained -- no Internet connection is necessary to use them. Download this carrel for offline reading. The carrel is made up of many subdirectories and data files. The manifest describes each one in greater detail.

Size

There are 137 item(s) in this carrel, and this carrel is 490,491 words long. Each item in your study carrel is, on average, 5,056 words long. If you dig deeper, then you might want to save yourself some time by reading a shorter item. On the other hand, if your desire is for more detail, then you might consider reading a longer item. The following charts illustrate the overall size of the carrel.

Readability

On a scale from 0 to 100, where 0 is very difficult and 100 is very easy, the documents have an average readability score of 53. Consequently, if you want to read something more simplistic, then consider a document with a higher score. If you want something more specialized, then consider something with a lower score. The following charts illustrate the overall readability of the carrel.

Word Frequencies

By merely counting & tabulating the frequency of individual words or phrases, you can begin to get an understanding of the carrel's "aboutness". Excluding "stop words", some of the more frequent words include:

cov, sars, rbd, protein, binding, ace, spike, receptor, coronavirus, human, cells, antibody, antibodies, using, virus, mers, cell, viral, infection, domain, covid, neutralizing, structure, igg, residues, also, proteins, two, patients, used, specific, respiratory, based, high, vaccine, data, neutralization, analysis, fc, anti, interaction, fusion, entry, well, syndrome, study, host, ml, shown, structural

Using the three most frequent words, the three files containing all of those words the most are The SARS-CoV-2 Spike Glycoprotein Biosynthesis, Structure, Function, and Antigenicity: Implications for the Design of Spike-Based Vaccine Immunogens, A zebrafish model for COVID-19 recapitulates olfactory and cardiovascular pathophysiologies caused by SARS-CoV-2, and Antibody response to SARS‐Co‐V‐2, diagnostic and therapeutic implications.

The most frequent two-word phrases (bigrams) include:

spike protein, respiratory syndrome, binding domain, syndrome coronavirus, neutralizing antibodies, receptor binding, acute respiratory, severe acute, human ace, spike glycoprotein, amino acid, middle east, east respiratory, cov rbd, novel coronavirus, coronavirus spike, sars coronavirus, converting enzyme, neutralizing antibody, cov spike, monoclonal antibodies, binding affinity, ace receptor, host cell, monoclonal antibody, author funder, antibody responses, immune responses, convalescent plasma, human monoclonal, copyright holder, amino acids, viral entry, immune response, cov infection, crystal structure, granted medrxiv, rbd protein, binding site, version posted, cell entry, ace binding, room temperature, spike proteins, host cells, doc id, cord uid, human coronavirus, coronavirus disease, kcal mol

And the three file that use all of the three most frequent phrases are Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities, and Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site.

While often deemed superficial or sophomoric, rudimentary frequencies and their associated "word clouds" can be quite insightful:

Keywords

Sets of keywords -- statistically significant words -- can be enumerated by comparing the relative frequency of words with the number of times the words appear in an entire corpus. Some of the most statistically significant keywords in the carrel include:

rbd, sars, ace2, mers, cov-2, protein, covid-19, elisa, spike, antibody, site, dpp4, d614, cell, supplementary, rna, patient, east, apn, zebrafish, vsv, virus, vhh, ty1, tnt, thp-1, tgev, tbs, supplemental, strain, sr31, selection, sb#68, sb#15, s55, s54, s377, s1+s2, s-2p, receptor, rbm, rbd219-n1c1, rbd(s, r441a, proanthocyanidin, prcv, plasma, pedv, ntd, ns1(rbd

And now word clouds really begin to shine:

Topic Modeling

Topic modeling is another popular approach to connoting the aboutness of a corpus. If the study carrel could be summed up in a single word, then that word might be cov, and Functional analysis of the receptor binding domain of SARS coronavirus S1 region and its monoclonal antibody is most about that word.

If the study carrel could be summed up in three words ("topics") then those words and their significantly associated titles include:

If the study carrel could be summed up in five topics, and each topic were each denoted with three words, then those topics and their most significantly associated files would be:

sars, ace2, rbd - Highly potent bispecific sybodies neutralize SARS-CoV-2
cov, rbd, mers - Chaperna-Mediated Assembly of Ferritin-Based Middle East Respiratory Syndrome-Coronavirus Nanoparticles
sars, cov, patients - The efficacy assessment of convalescent plasma therapy for COVID-19 patients: a multi-center case series
sars, cov, protein - Critical Interactions Between the SARS-CoV-2 Spike Glycoprotein and the Human ACE2 Receptor
sars, cov, protein - Prediction and mitigation of mutation threats to COVID-19 vaccines and antibody therapies

Moreover, the totality of the study carrel's aboutness, can be visualized with the following pie chart:

Noun & Verbs

Through an analysis of your study carrel's parts-of-speech, you are able to answer question beyonds aboutness. For example, a list of the most frequent nouns helps you answer what questions; "What is discussed in this collection?":

protein, spike, receptor, cells, antibodies, antibody, coronavirus, virus, cell, infection, domain, binding, residues, structure, proteins, patients, neutralization, vaccine, interaction, analysis, data, entry, fusion, study, host, site, affinity, assay, syndrome, response, mice, surface, results, expression, cov, responses, interactions, mutations, igg, glycoprotein, sequence, vaccines, region, model, studies, ml, serum, disease, subunit, complex

An enumeration of the verbs helps you learn what actions take place in a text or what the things in the text do. Very frequently, the most common lemmatized verbs are "be", "have", and "do"; the more interesting verbs usually occur further down the list of frequencies:

binding, using, showed, neutralizing, based, included, performed, indicates, containing, expressed, compared, blocking, following, identified, determining, inducing, found, suggested, targeting, observed, reveal, providing, incubated, reported, detected, obtaining, developed, mediating, described, added, generate, associated, increased, purified, measured, demonstrated, tested, analyzed, result, making, forming, reduce, produced, inhibit, collected, confirm, caused, predicted, displayed, infect

Proper Nouns

An extraction of proper nouns helps you determine the names of people and places in your study carrel.

SARS, RBD, CoV-2, ACE2, S, CoV, MERS, Fig, COVID-19, S1, S2, Fc, ELISA, sera, IgG, Figure, C, RNA, Coronavirus, Spike, Table, East, Middle, PBS, IgM, T, N, EM, MD, NTD, IgA, China, M, Supplementary, pH, RBM, PCR, mAbs, DPP4, K, Protein, PDB, Structure, A, B, Nbs, CoV-1, IFN, Human, APN

An analysis of personal pronouns enables you to answer at least two questions: 1) "What, if any, is the overall gender of my study carrel?", and 2) "To what degree are the texts in my study carrel self-centered versus inclusive?"

we, it, its, our, their, they, i, them, his, us, he, you, itself, one, your, themselves, rrbd-15, qag-2, iga1, my, s230, igg1, her, hace2, ab8, s, l452, iga2, ≥100, y505a, y453f, w.-h., u, she, sb#26, relion3.1, rasp-1, protein−protein, pro507, leu443, imagej, hrid, c526, b4galt7, asn501

Below are words cloud of your study carrel's proper & personal pronouns.

Adjectives & Verbs

Learning about a corpus's adjectives and adverbs helps you answer how questions: "How are things described and how are things done?" An analysis of adjectives and adverbs also points to a corpus's overall sentiment. "In general, is my study carrel positive or negative?"

human, viral, specific, high, respiratory, anti, severe, structural, different, immune, acute, single, molecular, novel, recombinant, higher, non, monoclonal, similar, potent, positive, clinical, potential, convalescent, available, therapeutic, several, conformational, negative, low, significant, effective, covid-19, new, functional, full, important, small, key, critical, first, multiple, large, major, antiviral, cellular, like, lower, free, dependent

also, well, respectively, however, highly, previously, therefore, significantly, recently, interestingly, first, together, moreover, even, directly, currently, prior, finally, relatively, likely, briefly, notably, furthermore, specifically, potentially, less, overnight, efficiently, alone, next, approximately, subsequently, additionally, still, similarly, indeed, strongly, rapidly, much, fully, importantly, least, especially, hence, overall, serially, particularly, effectively, completely, simultaneously

Next steps

There is much more to a study carrel than the things outlined above. Use this page's menubar to navigate and explore in more detail. There you will find additional features & functions including: ngrams, parts-of-speech, grammars, named entities, topic modeling, a simple search interface, etc.

Again, study carrels are self-contained. Download this carrel for offline viewing and use.

Thank you for using the Distant Reader.