This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.
trigram | frequency |
---|---|
as well as | 628 |
the presence of | 589 |
in order to | 563 |
structure of the | 414 |
one of the | 384 |
based on the | 377 |
of the protein | 345 |
the formation of | 336 |
the structure of | 317 |
the use of | 291 |
the development of | 290 |
due to the | 281 |
the number of | 274 |
in the presence | 268 |
the effect of | 262 |
can be used | 234 |
the role of | 233 |
the synthesis of | 217 |
a number of | 207 |
in this study | 197 |
of the peptide | 193 |
crystal structure of | 190 |
it has been | 188 |
analysis of the | 183 |
the active site | 176 |
a series of | 173 |
the mechanism of | 167 |
a variety of | 166 |
be used to | 164 |
to determine the | 159 |
to study the | 155 |
the design of | 155 |
in this work | 155 |
in addition to | 154 |
to investigate the | 152 |
the interaction of | 148 |
properties of the | 147 |
the case of | 147 |
involved in the | 146 |
part of the | 146 |
by means of | 143 |
a set of | 141 |
found to be | 137 |
show that the | 137 |
molecular dynamics simulations | 136 |
in the case | 136 |
the binding of | 133 |
in terms of | 131 |
the effects of | 130 |
that can be | 129 |
understanding of the | 128 |
was used to | 127 |
the study of | 127 |
of the most | 126 |
the crystal structure | 125 |
of the two | 124 |
of a protein | 124 |
the secondary structure | 124 |
well as the | 123 |
the aim of | 122 |
with respect to | 122 |
amino acid residues | 120 |
been shown to | 120 |
the analysis of | 120 |
shown to be | 120 |
to be a | 119 |
the identification of | 119 |
on the other | 118 |
in the present | 118 |
the amino acid | 118 |
a combination of | 116 |
the ability to | 116 |
have shown that | 115 |
changes in the | 114 |
role in the | 113 |
was found to | 112 |
has been shown | 111 |
the ability of | 111 |
the absence of | 111 |
structures of the | 110 |
is based on | 110 |
the importance of | 110 |
such as the | 110 |
as a result | 110 |
the surface of | 108 |
is one of | 108 |
the other hand | 107 |
there is a | 107 |
we found that | 106 |
structure of a | 105 |
of amino acids | 103 |
the results of | 103 |
related to the | 102 |
the influence of | 102 |
activity of the | 101 |
according to the | 101 |
the plasma membrane | 101 |
region of the | 100 |
the basis of | 100 |
of the human | 100 |
the treatment of | 99 |
used as a | 98 |
compared to the | 98 |
it is possible | 98 |
showed that the | 97 |
of the membrane | 97 |
the interaction between | 96 |
responsible for the | 96 |
the activity of | 96 |
to understand the | 96 |
an important role | 95 |
in which the | 95 |
based on a | 93 |
in the absence | 93 |
protein data bank | 92 |
the stability of | 92 |
the fact that | 90 |
some of the | 89 |
we show that | 89 |
results show that | 89 |
are able to | 88 |
important role in | 88 |
amino acid sequence | 88 |
were able to | 87 |
we have developed | 87 |
to that of | 87 |
nature of the | 87 |
formation of the | 87 |
the binding site | 87 |
shown that the | 86 |
on the surface | 86 |
role of the | 85 |
and in the | 85 |
were used to | 85 |
function of the | 85 |
the application of | 85 |
wide range of | 85 |
most of the | 85 |
a function of | 84 |
crystal structures of | 84 |
been used to | 84 |
suggest that the | 83 |
on the basis | 83 |
the present study | 82 |
large number of | 82 |
a wide range | 82 |
are involved in | 82 |
found that the | 81 |
the existence of | 80 |
the size of | 80 |
associated with the | 80 |
because of the | 80 |
stability of the | 80 |
depends on the | 79 |
the function of | 79 |
the structures of | 79 |
was carried out | 79 |
of the proteins | 79 |
formation of a | 79 |
of the binding | 79 |
be used for | 78 |
the regulation of | 78 |
the discovery of | 78 |
the structure and | 78 |
as a function | 77 |
residues in the | 77 |
in contrast to | 77 |
of the cell | 77 |
effect of the | 77 |
of this study | 77 |
was supported by | 77 |
of amino acid | 76 |
for the development | 76 |
were found to | 75 |
this work was | 75 |
of the structure | 75 |
structure and function | 74 |
to identify the | 73 |
will be discussed | 73 |
found in the | 73 |
have been used | 73 |
that of the | 73 |
will be presented | 73 |
of the rna | 72 |
of the n | 72 |
in the protein | 72 |
in the same | 72 |
phase peptide synthesis | 72 |
the free energy | 72 |
of the enzyme | 72 |
results suggest that | 71 |
in complex with | 71 |
is possible to | 71 |
are known to | 71 |
the conformation of | 70 |
used for the | 70 |
known to be | 70 |
aim of this | 70 |
in vitro and | 69 |
and in vivo | 69 |
in response to | 69 |
present in the | 69 |
the end of | 68 |
atomic force microscopy | 68 |
of the c | 68 |
depending on the | 68 |
study of the | 68 |
the rate of | 68 |
of the target | 67 |
we present a | 67 |
the nature of | 67 |
information on the | 67 |
a large number | 67 |
the range of | 67 |
binding to the | 67 |
the production of | 66 |
a range of | 66 |
is able to | 66 |
model of the | 66 |
be involved in | 66 |
revealed that the | 66 |
the process of | 66 |
rna secondary structures | 66 |
was shown to | 66 |
has been used | 65 |
the prediction of | 65 |
and can be | 65 |
to be the | 65 |
size of the | 65 |
in the pdb | 65 |
each of the | 65 |
insight into the | 64 |
characterization of the | 64 |
the dynamics of | 64 |
of the peptides | 64 |
which can be | 64 |
derived from the | 63 |
conformation of the | 63 |
surface of the | 63 |
binding of the | 63 |
due to its | 63 |
the accuracy of | 63 |
interaction with the | 63 |
the determination of | 63 |
interactions between the | 63 |
interaction of the | 63 |
for the treatment | 62 |
at the n | 62 |
the sequence of | 62 |
to evaluate the | 62 |
here we present | 62 |
is known to | 61 |
nuclear magnetic resonance | 61 |
mechanism of action | 61 |
is involved in | 61 |
information about the | 61 |
of the complex | 61 |
is used to | 61 |
as a model | 60 |
effect on the | 60 |
secondary structure of | 60 |
have been developed | 60 |
the kinetics of | 60 |
the target protein | 60 |
in combination with | 60 |
the level of | 60 |
we report the | 60 |
determination of the | 60 |
the majority of | 59 |
structural and functional | 59 |
has also been | 59 |
for the design | 59 |
at the c | 59 |
be used as | 59 |
similar to that | 59 |
of the same | 58 |
the lack of | 58 |
the properties of | 58 |
presence of a | 58 |
of the ligand | 58 |
to interact with | 58 |
key role in | 58 |
which is a | 58 |
a result of | 58 |
of the three | 58 |
of the amino | 58 |
of these peptides | 58 |
of the compounds | 58 |
there is no | 57 |
the amount of | 57 |
to predict the | 57 |
we have used | 57 |
used in the | 57 |
of the sars | 57 |
state of the | 57 |
of the virus | 57 |
to improve the | 57 |
mechanism of the | 57 |
proteins in the | 57 |
the distribution of | 57 |
d structure of | 56 |
we investigated the | 56 |
has not been | 56 |
a role in | 56 |
the cell membrane | 56 |
work was supported | 56 |
the detection of | 56 |
end of the | 56 |
length of the | 56 |
between the two | 56 |
and it is | 56 |
features of the | 56 |
can also be | 56 |
it was shown | 56 |
is required for | 56 |
of the viral | 55 |
biological activity of | 55 |
the protein data | 55 |
change in the | 55 |
presence of the | 55 |
due to their | 55 |
vitro and in | 55 |
of a new | 55 |
intrinsically disordered proteins | 55 |
in the cell | 55 |
we were able | 55 |
severe acute respiratory | 55 |
acute respiratory syndrome | 55 |
a key role | 55 |
in living cells | 55 |
the lipid bilayer | 54 |
seems to be | 54 |
leading to the | 54 |
the present work | 54 |
increase in the | 54 |
amino acid sequences | 54 |
this study we | 54 |
consistent with the | 54 |
is an important | 54 |
we have shown | 54 |
results indicate that | 54 |
members of the | 54 |
shown in fig | 54 |
it can be | 54 |
it was found | 54 |
insights into the | 53 |
rna secondary structure | 53 |
was used as | 52 |
is shown in | 52 |
study was to | 52 |
were carried out | 52 |
to elucidate the | 52 |
this study was | 52 |
to form a | 52 |
it is a | 51 |
member of the | 51 |
amino acids and | 51 |
indicate that the | 51 |
corresponding to the | 51 |
we have also | 51 |
close to the | 51 |
have also been | 51 |
for the synthesis | 51 |
of a novel | 51 |
of a single | 50 |
in the development | 50 |
of action of | 50 |
active site of | 50 |
all of the | 50 |
this work we | 50 |
play an important | 50 |
protein structure prediction | 50 |
in the membrane | 50 |
interaction between the | 50 |
and characterization of | 50 |
the quality of | 50 |
observed in the | 50 |
a database of | 50 |
solid phase peptide | 50 |
the degree of | 50 |
the length of | 50 |
and function of | 50 |
the combination of | 49 |
domain of the | 49 |
our understanding of | 49 |
appears to be | 49 |
is essential for | 49 |
shows that the | 49 |
to the formation | 49 |
at the same | 49 |
transmission electron microscopy | 49 |
that have been | 49 |
site of the | 49 |
suggests that the | 49 |
the possibility of | 49 |
the most common | 49 |
is due to | 49 |
and dynamics of | 49 |
van der waals | 49 |
some of these | 48 |
at the end | 48 |
the activation of | 48 |
the introduction of | 48 |
is responsible for | 48 |
have not been | 48 |
for the first | 48 |
was found that | 48 |
to analyze the | 48 |
use of the | 48 |
is associated with | 47 |
we present the | 47 |
the side chain | 47 |
led to the | 47 |
the preparation of | 47 |
respect to the | 47 |
has been developed | 47 |
the first time | 47 |
that there is | 47 |
of membrane proteins | 47 |
on the structure | 47 |
sequence of the | 47 |
we studied the | 47 |
a and b | 47 |
be used in | 46 |
in the first | 46 |
dynamics of the | 46 |
supported by the | 46 |
the fi rst | 46 |
used to determine | 46 |
located in the | 46 |
the characterization of | 46 |
of protein structure | 46 |
were shown to | 46 |
in the literature | 46 |
amino acids in | 46 |
to be involved | 45 |
the most important | 45 |
their ability to | 45 |
it is not | 45 |
in this context | 45 |
is crucial for | 45 |
results of the | 45 |
structure and dynamics | 45 |
we have studied | 45 |
addition to the | 45 |
in the range | 45 |
of the native | 45 |
are shown in | 45 |
have been identified | 45 |
differences in the | 45 |
in the brain | 45 |
knowledge of the | 45 |
the expression of | 45 |
regions of the | 45 |
free energy of | 45 |
of the interaction | 45 |
we showed that | 45 |
comparison of the | 45 |
dynamic light scattering | 44 |
structures in the | 44 |
formed by the | 44 |
studies of the | 44 |
determined by the | 44 |
the interaction with | 44 |
of these proteins | 44 |
characterized by a | 44 |
many of the | 44 |
as compared to | 44 |
to the protein | 44 |
isothermal titration calorimetry | 44 |
allowed us to | 44 |
development of a | 44 |
focused on the | 43 |
to explore the | 43 |
in this case | 43 |
interact with the | 43 |
we have investigated | 43 |
the concentration of | 43 |
need to be | 43 |
structural basis for | 43 |
contribute to the | 43 |
are used to | 43 |
amino acid composition | 43 |
the relationship between | 43 |
the wild type | 43 |
a total of | 42 |
which is the | 42 |
and molecular dynamics | 42 |
in recent years | 42 |
been shown that | 42 |
has been proposed | 42 |
of the sequence | 42 |
was shown that | 42 |
appear to be | 42 |
of protein structures | 42 |
of the dna | 42 |
a family of | 42 |
we have found | 42 |
of this work | 42 |
the context of | 42 |
the biological activity | 42 |
have been found | 42 |
of proteins and | 42 |
department of chemistry | 42 |
scanning electron microscopy | 41 |
fluorescence correlation spectroscopy | 41 |
than that of | 41 |
the growth of | 41 |
by using the | 41 |
in the regulation | 41 |
dependent on the | 41 |
leads to the | 41 |
is that the | 41 |
academy of sciences | 41 |
in the sequence | 41 |
were synthesized by | 41 |
to assess the | 41 |
applied to the | 41 |
is a key | 41 |
of the molecule | 41 |
used to study | 41 |
central nervous system | 41 |
together with the | 41 |
the search for | 41 |
of rna secondary | 41 |
peptides and proteins | 41 |
different types of | 41 |
followed by a | 41 |
basis of the | 40 |
in agreement with | 40 |
the course of | 40 |
of a large | 40 |
our results show | 40 |
we developed a | 40 |
belongs to the | 40 |
it is also | 40 |
demonstrated that the | 40 |
the inhibition of | 40 |
a member of | 40 |
to the membrane | 40 |
have been studied | 40 |
position of the | 40 |
suggested that the | 40 |
studies on the | 40 |
important for the | 40 |
resulted in the | 40 |
the generation of | 40 |
is important to | 39 |
is composed of | 39 |
in the formation | 39 |
interactions with the | 39 |
the incorporation of | 39 |
of secondary structure | 39 |
here we report | 39 |
in the structure | 39 |
are characterized by | 39 |
the action of | 39 |
well as in | 39 |
compared with the | 39 |
to obtain the | 39 |
synthesis of the | 39 |
for the study | 39 |
leads to a | 39 |
depend on the | 39 |
attached to the | 39 |
to characterize the | 39 |
shown in figure | 39 |
could be used | 39 |
binding site of | 39 |
secondary structure prediction | 38 |
basis for the | 38 |
it is important | 38 |
the protein is | 38 |
the interactions between | 38 |
similar to the | 38 |
prediction of protein | 38 |
regulation of the | 38 |
plays an important | 38 |
the cell surface | 38 |
surface plasmon resonance | 38 |
the set of | 38 |
component of the | 38 |
the structural and | 38 |
in comparison with | 38 |
for drug discovery | 38 |
of the a | 38 |
the purpose of | 38 |
peptides derived from | 38 |
better understanding of | 38 |
in the binding | 38 |
the same time | 38 |
of intrinsic disorder | 38 |
in aqueous solution | 38 |
of which are | 38 |
the mechanisms of | 38 |
this is the | 38 |
obtained from the | 38 |
in the past | 38 |
bound to the | 38 |
of the molecular | 38 |
side of the | 38 |
the synthesis and | 38 |
a model of | 38 |
be able to | 38 |
have been shown | 37 |
development of new | 37 |
new class of | 37 |
the d structure | 37 |
be considered as | 37 |
these results suggest | 37 |
is the most | 37 |
the protein structure | 37 |
of the reaction | 37 |
are based on | 37 |
an example of | 37 |
in the field | 37 |
secondary and tertiary | 37 |
referred to as | 37 |
in case of | 37 |
and that the | 37 |
is characterized by | 37 |
of the lipid | 37 |
in this way | 37 |
by using a | 37 |
the position of | 37 |
is believed to | 37 |
also known as | 37 |
likely to be | 37 |
effects of the | 37 |
the assembly of | 36 |
acts as a | 36 |
out of the | 36 |
secondary structure elements | 36 |
in presence of | 36 |
has been suggested | 36 |
human immunodeficiency virus | 36 |
a protein structure | 36 |
orientation of the | 36 |
with the same | 36 |
in the following | 36 |
of proteins in | 36 |
increase of the | 36 |
the impact of | 36 |
method for the | 36 |
agreement with the | 36 |
in the context | 36 |
the order of | 36 |
we have been | 36 |
of the s | 36 |
to be used | 36 |
caused by the | 36 |
investigation of the | 36 |
results showed that | 36 |
suggesting that the | 36 |
the basis for | 36 |
this type of | 36 |
the investigation of | 35 |
influence of the | 35 |
inhibitors of the | 35 |
inhibition of the | 35 |
of the active | 35 |
based on these | 35 |
we used the | 35 |
the field of | 35 |
model for the | 35 |
can be found | 35 |
the changes in | 35 |
we find that | 35 |
and of the | 35 |
the results obtained | 35 |
belonging to the | 35 |
the amino acids | 35 |
have to be | 35 |
of a peptide | 35 |
and for the | 35 |
based drug design | 35 |
resulted in a | 35 |
by the presence | 35 |
the binding pocket | 35 |
be applied to | 35 |
synthesis of a | 35 |
of all the | 35 |
that it is | 35 |
molecular mechanism of | 35 |
ability of the | 35 |
of the receptor | 35 |
of this protein | 35 |
of the model | 35 |
as shown in | 35 |
two types of | 35 |
of the main | 35 |
residues of the | 35 |
a powerful tool | 35 |
step in the | 34 |
required for the | 34 |
have developed a | 34 |
this work is | 34 |
structure in the | 34 |
serve as a | 34 |
results in a | 34 |
the understanding of | 34 |
has to be | 34 |
accuracy of the | 34 |
can be obtained | 34 |
to each other | 34 |
is important for | 34 |
based on their | 34 |
to bind to | 34 |
the molecular level | 34 |
contrast to the | 34 |
of the different | 34 |
in the central | 34 |
on the cell | 34 |
of the first | 34 |
allows us to | 34 |
of antimicrobial peptides | 34 |
vp vp vp | 34 |
the release of | 34 |
of the resulting | 34 |
have been reported | 34 |
to be more | 34 |
have been proposed | 34 |
for this purpose | 33 |
are responsible for | 33 |
the addition of | 33 |
was applied to | 33 |
the evolution of | 33 |
de novo design | 33 |
organization of the | 33 |
be related to | 33 |
in silico pharmacology | 33 |
the results show | 33 |
in drug discovery | 33 |
was used for | 33 |
we have recently | 33 |
to obtain a | 33 |
can be applied | 33 |
there is an | 33 |
has been studied | 33 |
the eudoc program | 33 |
dynamics simulations of | 33 |
is consistent with | 33 |
the interactions of | 33 |
to play a | 33 |
the side chains | 33 |
been found to | 33 |
and in vitro | 33 |
in the last | 33 |
the first step | 33 |
resonance energy transfer | 33 |
at least one | 33 |
of the secondary | 33 |
proteins involved in | 33 |
considered to be | 33 |
of the sample | 33 |
of the major | 33 |
to develop a | 33 |
in the n | 33 |
terminal domain of | 33 |
the potential of | 33 |
protein structure and | 32 |
mode of action | 32 |
with the aim | 32 |
thought to be | 32 |
point of view | 32 |
is a powerful | 32 |
the central nervous | 32 |
intrinsic disorder in | 32 |
the host cell | 32 |
the complexity of | 32 |
structural analysis of | 32 |
one or more | 32 |
structures can be | 32 |
to increase the | 32 |
at least two | 32 |
of the molecules | 32 |
in the future | 32 |
used to identify | 32 |
a model system | 32 |
dependence of the | 32 |
the location of | 32 |
components of the | 32 |
of protein folding | 32 |
the human genome | 32 |
be responsible for | 32 |
in a single | 32 |
for the binding | 31 |
proteins can be | 31 |
dependent rna polymerase | 31 |
bind to the | 31 |
was studied by | 31 |
an increase in | 31 |
the in vitro | 31 |
solid phase synthesis | 31 |
conformational changes in | 31 |
to the presence | 31 |
data suggest that | 31 |
in vivo and | 31 |
assembly of the | 31 |
was able to | 31 |
reduction of the | 31 |
rational design of | 31 |
evaluation of the | 31 |
to inhibit the | 31 |
a class of | 31 |
are associated with | 31 |
form of the | 31 |
its interaction with | 31 |
in some cases | 31 |
as a consequence | 31 |
designed and synthesized | 31 |
on the protein | 31 |
because of their | 31 |
the construction of | 30 |
of the structures | 30 |
and on the | 30 |
have investigated the | 30 |
the tertiary structure | 30 |
em structure of | 30 |
in the peptide | 30 |
consists of a | 30 |
methods have been | 30 |
to have a | 30 |
parts of the | 30 |
the crystal structures | 30 |
interactions in the | 30 |
of the four | 30 |
of secondary structures | 30 |
is the first | 30 |
we propose that | 30 |
has been determined | 30 |
in a protein | 30 |
in the crystal | 30 |
a group of | 30 |
at the molecular | 30 |
secondary structure and | 30 |
details of the | 30 |
importance of the | 30 |
could not be | 30 |
the molecular mechanism | 30 |
to the cell | 30 |
be important for | 30 |
distribution of the | 30 |
of these two | 30 |
so that the | 30 |
the resolution of | 30 |
carried out using | 30 |
the type of | 30 |
molecules in the | 30 |
we will present | 30 |
wide variety of | 30 |
the significance of | 30 |
which has been | 30 |
of the catalytic | 30 |
is used for | 30 |
is related to | 30 |
structural characterization of | 30 |
the behavior of | 30 |
the binding affinity | 30 |
may lead to | 29 |
for the detection | 29 |
it is well | 29 |
is known that | 29 |
we used a | 29 |
activation of the | 29 |
in escherichia coli | 29 |
is a very | 29 |
the performance of | 29 |
energy of the | 29 |
prediction of the | 29 |
at room temperature | 29 |
the concept of | 29 |
structure determination of | 29 |
based virtual screening | 29 |
the molecular mechanisms | 29 |
were used as | 29 |
has been found | 29 |
when compared to | 29 |
in the early | 29 |
the folding of | 29 |
seem to be | 29 |
the occurrence of | 29 |
starting from the | 29 |
as in the | 29 |
results in the | 29 |
a secondary structure | 29 |
of the system | 29 |
it is known | 29 |
identification of a | 29 |
by nmr spectroscopy | 29 |
can be easily | 29 |
diseases such as | 29 |
of the surface | 29 |
believed to be | 29 |
that there are | 29 |
we have synthesized | 29 |
in the c | 29 |
can be considered | 29 |
of the full | 29 |
and the other | 29 |
a crucial role | 29 |
because of its | 29 |
use of a | 29 |
have found that | 29 |
changes of the | 29 |
conformational changes of | 29 |
carried out by | 29 |
taken into account | 29 |
of these structures | 29 |
shape of the | 28 |
isolated from the | 28 |
lead to the | 28 |
the rest of | 28 |
values of the | 28 |
has been reported | 28 |
be due to | 28 |
core of the | 28 |
in most cases | 28 |
we have designed | 28 |
of the new | 28 |
its ability to | 28 |
molecular dynamics simulation | 28 |
effects on the | 28 |
is necessary to | 28 |
in the second | 28 |
act as a | 28 |
indicated that the | 28 |
dimensional structure of | 28 |
the peptides were | 28 |
the loss of | 28 |
are important for | 28 |
to measure the | 28 |
the goal of | 28 |
the control of | 28 |
in the human | 28 |
with a high | 28 |
that could be | 28 |
in a variety | 28 |
in the treatment | 28 |
linked to the | 28 |
a change in | 28 |
of these compounds | 28 |
this is a | 28 |
to examine the | 28 |
the evaluation of | 28 |
we have previously | 28 |
serves as a | 28 |
has recently been | 28 |
dimensional structures of | 28 |
similar to those | 28 |
structure and the | 28 |
in the active | 28 |
we propose a | 28 |
proven to be | 28 |
reactive oxygen species | 28 |
is likely to | 28 |
of structural biology | 28 |
proved to be | 28 |
crucial for the | 28 |
difference between the | 28 |
amino acid residue | 27 |
the affinity of | 27 |
a part of | 27 |
peptides were synthesized | 27 |
play a role | 27 |
in this paper | 27 |
needs to be | 27 |
light on the | 27 |
with high affinity | 27 |
is present in | 27 |
the form of | 27 |
mechanical properties of | 27 |
that they are | 27 |
identifi cation of | 27 |
view of the | 27 |
to the active | 27 |
design of new | 27 |
been applied to | 27 |
binds to the | 27 |
identification of the | 27 |
of a small | 27 |
expected to be | 27 |
is mediated by | 27 |
in the s | 27 |
a mixture of | 27 |
to better understand | 27 |
located at the | 27 |
force field for | 27 |
correlation between the | 27 |
leading to a | 27 |
for the discovery | 27 |
is thought to | 27 |
to the same | 27 |
data on the | 27 |
of the crystal | 27 |
we describe the | 27 |
to calculate the | 27 |
data show that | 27 |
composition of the | 27 |
studies showed that | 27 |
considered as a | 27 |
of the p | 27 |
a highly conserved | 27 |
was determined by | 27 |
native chemical ligation | 27 |
recent advances in | 27 |
a wide variety | 27 |
and biological activity | 27 |
along with the | 27 |
and the c | 27 |
activity in the | 27 |
this study is | 27 |
mediated by the | 27 |
plays a key | 27 |
it should be | 27 |
may be a | 27 |
may not be | 27 |
some of them | 26 |
of the entire | 26 |
the details of | 26 |
there are several | 26 |
to those of | 26 |
were subjected to | 26 |
more than one | 26 |
high affi nity | 26 |
studies have shown | 26 |
be found in | 26 |
have been described | 26 |
side chains of | 26 |
is capable of | 26 |
were used for | 26 |
of the conformational | 26 |
cleavage of the | 26 |
order to obtain | 26 |
deposited in the | 26 |
case of the | 26 |
sequence and structure | 26 |
powerful tool for | 26 |
the efficiency of | 26 |
affected by the | 26 |
relies on the | 26 |
allow us to | 26 |
institute of technology | 26 |
terminus of the | 26 |
essential for the | 26 |
been implicated in | 26 |
crucial role in | 26 |
department of physics | 26 |
to reduce the | 26 |
that may be | 26 |
access to the | 26 |
is supported by | 26 |
were synthesized and | 26 |
a comparison of | 26 |
been suggested that | 26 |
induced by the | 26 |
of such a | 26 |
of the second | 26 |
relative to the | 26 |
the specificity of | 26 |
which have been | 26 |
confocal laser scanning | 26 |
to the n | 26 |
characterization of a | 26 |
to test the | 26 |
and development of | 26 |
a method for | 26 |
the availability of | 26 |
that has been | 26 |
this approach is | 26 |
a better understanding | 26 |
a model for | 26 |
used to predict | 26 |
the orientation of | 26 |
belong to the | 26 |
of small molecules | 26 |
based on this | 26 |
a new method | 26 |
in the design | 26 |
were prepared by | 26 |
virtual screening of | 26 |
proteins and their | 26 |
has been recently | 26 |
with and without | 26 |
a new class | 25 |
the protein surface | 25 |
of proteins with | 25 |
a library of | 25 |
side chain of | 25 |
rest of the | 25 |
attributed to the | 25 |
as an example | 25 |
a basis for | 25 |
these peptides are | 25 |
we believe that | 25 |
of more than | 25 |
amino acids were | 25 |
characterized by the | 25 |
are found in | 25 |
scanning electron microscope | 25 |
and tertiary structure | 25 |
change of the | 25 |
are the most | 25 |
properties of a | 25 |
the results are | 25 |
our results suggest | 25 |
is essential to | 25 |
binding sites in | 25 |
to understand how | 25 |
amino acids are | 25 |
were characterized by | 25 |
into account the | 25 |
interacts with the | 25 |
of the drug | 25 |
and structure of | 25 |
size exclusion chromatography | 25 |
in the two | 25 |
quality of the | 25 |
well as to | 25 |
the organization of | 25 |
to the structure | 25 |
consists of two | 25 |
protein in the | 25 |
due to a | 25 |
by solid phase | 25 |
we demonstrate that | 25 |
correlated with the | 25 |
molecular basis of | 25 |
been developed for | 25 |
the result of | 25 |
of peptides and | 25 |
have been investigated | 25 |
that are not | 24 |
and has been | 24 |
background and aims | 24 |
is a major | 24 |
are used in | 24 |
indicating that the | 24 |
we investigate the | 24 |
is determined by | 24 |
the compounds were | 24 |
in the plasma | 24 |
we conclude that | 24 |
structural properties of | 24 |
of the host | 24 |
of the folding | 24 |
majority of the | 24 |
indicates that the | 24 |
part of a | 24 |
of base pairs | 24 |
we suggest that | 24 |
of the structural | 24 |
order to study | 24 |
a major role | 24 |
the polypeptide chain | 24 |
the university of | 24 |
tool for the | 24 |
the difference in | 24 |
the protein and | 24 |
we report on | 24 |
in the identification | 24 |
evolution of the | 24 |
low molecular weight | 24 |
and nucleic acids | 24 |
and to the | 24 |
the viral rna | 24 |
limited number of | 24 |
structures have been | 24 |
be useful for | 24 |
only a few | 24 |
the most potent | 24 |
to monitor the | 24 |
carried out in | 24 |
been found in | 24 |
processes such as | 24 |
differential scanning calorimetry | 24 |
structure of human | 24 |
the molecular basis | 24 |
aim is to | 24 |
using a combination | 24 |
is dependent on | 24 |
in relation to | 24 |
amino acid side | 24 |
this suggests that | 24 |
to create a | 24 |
in our laboratory | 24 |
that do not | 24 |
work was to | 24 |
be associated with | 24 |
is formed by | 24 |
small angle x | 24 |
institute of biophysics | 24 |
the possibility to | 24 |
by molecular dynamics | 24 |
those of the | 24 |
the local structures | 24 |
focus on the | 24 |
is known about | 24 |
on the membrane | 24 |
they can be | 24 |
interacting with the | 24 |
orders of magnitude | 24 |
starting point for | 24 |
taking into account | 24 |
of rna structure | 24 |
differences between the | 24 |
to explain the | 24 |
the aggregation of | 24 |
it is the | 24 |
protein can be | 24 |
of a given | 24 |
proteins and peptides | 24 |
for the prediction | 24 |
to form the | 24 |
used as the | 24 |
in other words | 24 |
the target sequence | 24 |
in spite of | 24 |
in the cytoplasm | 23 |
we report a | 23 |
the center of | 23 |
is the main | 23 |
order to understand | 23 |
of amyloid fibrils | 23 |
may be used | 23 |
affinity of the | 23 |
to control the | 23 |
the experimental data | 23 |
were obtained from | 23 |
advantage of the | 23 |
it possible to | 23 |
states of the | 23 |
of local structures | 23 |
we demonstrated that | 23 |
evidence that the | 23 |
simulations of the | 23 |
and analysis of | 23 |
also in the | 23 |
high degree of | 23 |
in comparison to | 23 |
across the membrane | 23 |
sites of the | 23 |
of glutamic acid | 23 |
the most promising | 23 |
for the preparation | 23 |
concentration of the | 23 |
by circular dichroism | 23 |
the in vivo | 23 |
the pathogenesis of | 23 |
the increase of | 23 |
on the use | 23 |
both in the | 23 |
it may be | 23 |
the help of | 23 |
of the backbone | 23 |
added to the | 23 |
cell penetrating peptides | 23 |
it is necessary | 23 |
structural features of | 23 |
upon binding to | 23 |
carried out on | 23 |
resulting in the | 23 |
molecular mechanisms of | 23 |
the design and | 23 |
were tested for | 23 |
a consequence of | 23 |
of protein function | 23 |
flexibility of the | 23 |
been used for | 23 |
on the interaction | 23 |
has been demonstrated | 23 |
ray crystallography and | 23 |
in many cases | 23 |
that the protein | 23 |
amino acids with | 23 |
of the free | 23 |
of the hiv | 23 |
the calculation of | 23 |
the hypothesis that | 23 |
for the identification | 23 |
of the complexes | 23 |
in the process | 23 |
the contribution of | 23 |
the peptide backbone | 23 |
secondary structure is | 23 |
conformational analysis of | 23 |
to the development | 23 |
glutamic acid residues | 23 |
the problem of | 23 |
complex with the | 23 |
to describe the | 23 |
proteins of the | 23 |
the mode of | 23 |
we aim to | 22 |
in the number | 22 |
that the structure | 22 |
a hydrogen bond | 22 |
the selection of | 22 |
of this enzyme | 22 |
corresponds to the | 22 |
mutations in the | 22 |
antimicrobial activity against | 22 |
d structures of | 22 |
example of a | 22 |
and stability of | 22 |
such as a | 22 |
work is to | 22 |
a decrease in | 22 |
the extent of | 22 |
liu et al | 22 |
conformations of the | 22 |
the reaction of | 22 |
been identified in | 22 |
is a potent | 22 |
the association of | 22 |
by mass spectrometry | 22 |
peptides have been | 22 |
is represented by | 22 |
structure of an | 22 |
approaches have been | 22 |
has led to | 22 |
interactions of the | 22 |
which may be | 22 |
is well known | 22 |
to find the | 22 |
study is to | 22 |
removal of the | 22 |
to show that | 22 |
each of these | 22 |
of the electron | 22 |
more stable than | 22 |
of the residues | 22 |
existence of a | 22 |
known as the | 22 |
the distance between | 22 |
the increase in | 22 |
unnatural amino acids | 22 |
amino acids that | 22 |
associated with a | 22 |
complexity of the | 22 |
of the present | 22 |
of the protease | 22 |
under physiological conditions | 22 |
is achieved by | 22 |
action of the | 22 |
distance between the | 22 |
are essential for | 22 |
in conjunction with | 22 |
the shape of | 22 |
on the molecular | 22 |
of the d | 22 |
resulting from the | 22 |
description of the | 22 |
to determine whether | 22 |
in the rat | 22 |
to provide a | 22 |
of the natural | 22 |
but it is | 22 |
plasma membrane of | 22 |
rdrp suppl table | 22 |
of hydrogen bonds | 22 |
is not a | 22 |
web server for | 22 |
geometry of the | 22 |
structural basis of | 22 |
atoms of the | 22 |
on the structural | 22 |
to be an | 22 |
has been observed | 22 |
of a series | 22 |
and the structure | 22 |
is similar to | 22 |
is possible that | 22 |
of this approach | 22 |
modification of the | 22 |
two of the | 22 |
portion of the | 22 |
of the substrate | 22 |
from the protein | 22 |
small number of | 22 |
well as their | 22 |
were determined by | 22 |
hepatitis c virus | 22 |
to estimate the | 22 |
half of the | 22 |
affinity for the | 22 |
solution structure of | 22 |
application of the | 22 |
is still a | 22 |
were obtained by | 22 |
of the other | 22 |
order to investigate | 22 |
respiratory syndrome coronavirus | 22 |
was to investigate | 22 |
it does not | 22 |
has shown that | 22 |
characteristics of the | 21 |
the conformational changes | 21 |
the focus of | 21 |
led to a | 21 |
an understanding of | 21 |
is in the | 21 |
lead to a | 21 |
multiple sequence alignment | 21 |
a way that | 21 |
of both the | 21 |
tested for their | 21 |
in the other | 21 |
the extracellular matrix | 21 |
difference in the | 21 |
provided by the | 21 |
can be observed | 21 |
of the non | 21 |
model based on | 21 |
nucleotides in the | 21 |
demonstrate that the | 21 |
was observed in | 21 |
acid residues in | 21 |
in the form | 21 |
the secondary structures | 21 |
we use the | 21 |
this class of | 21 |
the binding sites | 21 |
has been identified | 21 |
university of california | 21 |
results from the | 21 |
with the protein | 21 |
mechanisms of action | 21 |
are likely to | 21 |
been widely used | 21 |
a method to | 21 |
broad range of | 21 |
of the genome | 21 |
interest in the | 21 |
resolution of the | 21 |
seen in the | 21 |
of the b | 21 |
the potential to | 21 |
roles in the | 21 |
with that of | 21 |
an in vitro | 21 |
profile of the | 21 |
to be highly | 21 |
the core of | 21 |
by interacting with | 21 |
can be seen | 21 |
terminal part of | 21 |
little is known | 21 |
the measurement of | 21 |
inhibitor of the | 21 |
the correlation between | 21 |
potent and selective | 21 |
have been characterized | 21 |
proteins have been | 21 |
development of the | 21 |
to the peptide | 21 |
is expected to | 21 |
science and technology | 21 |
order to determine | 21 |
to generate a | 21 |
can serve as | 21 |
the geometry of | 21 |
able to bind | 21 |
prediction of rna | 21 |
peptides and their | 21 |
calculation of the | 21 |
decrease of the | 21 |
have studied the | 21 |
of the plasma | 21 |
structure has been | 21 |
to detect the | 21 |
to the surface | 21 |
and amino acid | 21 |
aim of the | 21 |
site in the | 21 |
structures of proteins | 21 |
during the last | 21 |
of the compound | 21 |
to be important | 21 |
the conversion of | 21 |
of the known | 20 |
physical properties of | 20 |
fact that the | 20 |
is regulated by | 20 |
dynamics of a | 20 |
of the corresponding | 20 |
parallel to the | 20 |
of molecular dynamics | 20 |
in the study | 20 |
good agreement with | 20 |
a protein is | 20 |
in a wide | 20 |
of the primary | 20 |
that the n | 20 |
laser scanning microscopy | 20 |
with the help | 20 |
one of these | 20 |
for understanding the | 20 |
to the high | 20 |
developed for the | 20 |
can then be | 20 |
the peptide sequence | 20 |
structural studies of | 20 |
results demonstrate that | 20 |
binding affinity of | 20 |
of the polypeptide | 20 |
the similarity of | 20 |
observed for the | 20 |
to compare the | 20 |
proteins such as | 20 |
were used in | 20 |
is a member | 20 |
as a new | 20 |
the frequency of | 20 |
as determined by | 20 |
department of biophysics | 20 |
are related to | 20 |
is difficult to | 20 |
design and synthesis | 20 |
a novel approach | 20 |
used as an | 20 |
as a template | 20 |
we focus on | 20 |
plays a role | 20 |
are expected to | 20 |
with each other | 20 |
an ensemble of | 20 |
nmr studies of | 20 |
location of the | 20 |
limited by the | 20 |
for binding to | 20 |
the value of | 20 |
of the individual | 20 |
was obtained by | 20 |
in the course | 20 |
in both the | 20 |
the catalytic domain | 20 |
could be a | 20 |
a resolution of | 20 |
of intrinsically disordered | 20 |
have been synthesized | 20 |
we observed that | 20 |
the observation that | 20 |
behavior of the | 20 |
the most active | 20 |
have been determined | 20 |
an attempt to | 20 |
of the nucleocapsid | 20 |
resulting in a | 20 |
of water molecules | 20 |
kinetics of the | 20 |
been studied by | 20 |
graduate school of | 20 |
parameters of the | 20 |
the method is | 20 |
binding of a | 20 |
were performed in | 20 |
secondary structure in | 20 |
over the past | 20 |
of the t | 20 |
been developed to | 20 |
binding free energy | 20 |
for the formation | 20 |
of the g | 20 |
to optimize the | 20 |
cells of the | 20 |
in the search | 20 |
in vivo studies | 20 |
it will be | 20 |
of at least | 20 |
relationship between the | 20 |
studies have been | 20 |
the native state | 20 |
this process is | 20 |
of crystal packing | 20 |
we will show | 20 |
for in vivo | 20 |
cells in the | 20 |
and synthesis of | 20 |
with the membrane | 20 |
phase synthesis of | 20 |
we analyzed the | 20 |
a high degree | 20 |
the modulation of | 20 |
can be achieved | 20 |
approach for the | 20 |
followed by the | 20 |
the creation of | 20 |
approach to the | 20 |
of the whole | 20 |
a critical role | 19 |
in the model | 19 |
of negatively charged | 19 |
and molecular modeling | 19 |
the change in | 19 |
presence of an | 19 |
also be used | 19 |
of the functional | 19 |
to act as | 19 |
secondary structures of | 19 |
suitable for the | 19 |
on the contrary | 19 |
of a number | 19 |
it was also | 19 |
of the data | 19 |
we report here | 19 |
base pair similarity | 19 |
as a potential | 19 |
coordinates of the | 19 |
many of these | 19 |
it was suggested | 19 |
incorporated into the | 19 |
drug discovery process | 19 |
infl uence of | 19 |
techniques such as | 19 |
for each of | 19 |
and found that | 19 |
a target for | 19 |
green fluorescent protein | 19 |
be explained by | 19 |
of our study | 19 |
analysis of a | 19 |
a starting point | 19 |
methods such as | 19 |
is a well | 19 |
purpose of this | 19 |
in the lipid | 19 |
we focused on | 19 |
binding mode of | 19 |
influence on the | 19 |
the reduction of | 19 |
to probe the | 19 |
critical role in | 19 |
potential of the | 19 |
tertiary structure of | 19 |
included in the | 19 |
in the nucleus | 19 |
the viral genome | 19 |
the need for | 19 |
as part of | 19 |
the electron density | 19 |
proteins and nucleic | 19 |
linked to a | 19 |
it is shown | 19 |
on the sequence | 19 |
all of these | 19 |
in the vicinity | 19 |
a subset of | 19 |
the primary structure | 19 |
due to an | 19 |
to reveal the | 19 |
binding site for | 19 |
is a highly | 19 |
the sequence and | 19 |
the native structure | 19 |
in mammalian cells | 19 |
residues involved in | 19 |
of a few | 19 |
the morphology of | 19 |
the binding mode | 19 |
for virtual screening | 19 |
secondary structures are | 19 |
identified in the | 19 |
can lead to | 19 |
assumed to be | 19 |
acid sequence of | 19 |
of gene expression | 19 |
in a large | 19 |
of the wild | 19 |
in our study | 19 |
is an essential | 19 |
be divided into | 19 |
sensitive to the | 19 |
design of a | 19 |
of biologically active | 19 |
binding sites of | 19 |
positions of the | 19 |
of the local | 19 |
the differences in | 19 |
defined by the | 19 |
any of the | 19 |
are present in | 19 |
affi nity for | 19 |
for drug design | 19 |
as it is | 19 |
in the viral | 19 |
gives rise to | 19 |
of in silico | 19 |
goal is to | 19 |
can be determined | 19 |
composed of a | 19 |
of the selected | 19 |
cancer cell lines | 19 |
the origin of | 19 |
major role in | 19 |
proteins that are | 19 |
have been made | 19 |
a new approach | 19 |
in which a | 19 |
an effort to | 19 |
morphology of the | 19 |
for a given | 19 |
linear and cyclic | 19 |
and the binding | 19 |
give rise to | 19 |
we examined the | 19 |
in an effort | 19 |
of the original | 19 |
observed that the | 19 |
design of novel | 19 |
glutamic acid is | 19 |
position in the | 19 |
secondary structures with | 19 |
density of the | 19 |
analysis revealed that | 19 |
the dependence of | 19 |
been proposed to | 19 |
have demonstrated that | 19 |
binding site on | 18 |
formation of an | 18 |
and with the | 18 |
a small number | 18 |
here we show | 18 |
were identified by | 18 |
been carried out | 18 |
of them are | 18 |
correspond to the | 18 |
by the formation | 18 |
the vicinity of | 18 |
of the interactions | 18 |
there are many | 18 |
novo design of | 18 |
of an rna | 18 |
of science and | 18 |
is a promising | 18 |
the toxicity of | 18 |
in a way | 18 |
terminal region of | 18 |
zhang et al | 18 |
the outer membrane | 18 |
to be considered | 18 |
there are two | 18 |
binding domain of | 18 |
at the level | 18 |
in the interaction | 18 |
these proteins are | 18 |
binding properties of | 18 |
development of novel | 18 |
that the binding | 18 |
we are interested | 18 |
and there is | 18 |
has been widely | 18 |
we present an | 18 |
was monitored by | 18 |
do not have | 18 |
homology model of | 18 |
the main chain | 18 |
the major groove | 18 |
can be divided | 18 |
protein secondary structure | 18 |
can only be | 18 |
protein from the | 18 |
of the helix | 18 |
the inclusion of | 18 |
the results showed | 18 |
analysis of protein | 18 |
on a single | 18 |
structures and functions | 18 |
present work we | 18 |
has been described | 18 |
in live cells | 18 |
here we describe | 18 |
the involvement of | 18 |
properties of these | 18 |
a crystal structure | 18 |
protein of the | 18 |
a pair of | 18 |
of the transition | 18 |
efficiency of the | 18 |
only in the | 18 |
essential role in | 18 |
comparison with the | 18 |
divided into two | 18 |
at the single | 18 |
for the investigation | 18 |
of escherichia coli | 18 |
combined with the | 18 |
of the cells | 18 |
the past years | 18 |
protein and the | 18 |
were calculated using | 18 |
structures and the | 18 |
that the peptide | 18 |
for use in | 18 |
be the most | 18 |
sequences of the | 18 |
at least in | 18 |
with the use | 18 |
the elucidation of | 18 |
by a single | 18 |
was studied in | 18 |
in silico screening | 18 |
mechanism by which | 18 |
of some of | 18 |
will be used | 18 |
for all the | 18 |
picture of the | 18 |
example of the | 18 |
in the low | 18 |
the membrane and | 18 |
to the synthesis | 18 |
the values of | 18 |
of the large | 18 |
the fraction of | 18 |
stabilization of the | 18 |
the minor groove | 18 |
discovery of new | 18 |
an increase of | 18 |
the flexibility of | 18 |
there has been | 18 |
biologically active peptides | 18 |
are required to | 18 |
was performed in | 18 |
one of them | 18 |
in regulation of | 18 |
for protein structure | 18 |
which in turn | 18 |
for the interaction | 18 |
we demonstrate the | 18 |
release of the | 18 |
of living cells | 18 |
protein intrinsic disorder | 18 |
as one of | 18 |
to the target | 18 |
was investigated by | 18 |
the template structure | 18 |
with a single | 18 |
s and s | 18 |
in view of | 18 |
unfolding of the | 18 |
functions of the | 18 |
binding site in | 18 |
results indicated that | 18 |
is widely used | 18 |
for treatment of | 18 |
the sum of | 18 |
to overcome this | 18 |
from the n | 18 |
fraction of the | 18 |
in silico methods | 18 |
of binding sites | 18 |
the appearance of | 18 |
p x r | 17 |
with the active | 17 |
the variation of | 17 |
combination of the | 17 |
increasing number of | 17 |
in both cases | 17 |
experiments showed that | 17 |
is caused by | 17 |
by a combination | 17 |
the types of | 17 |
are consistent with | 17 |
has been applied | 17 |
groups of the | 17 |
share a common | 17 |
high levels of | 17 |
conclude that the | 17 |
of the in | 17 |
the virtual screening | 17 |
the sars coronavirus | 17 |
ability to form | 17 |
of the cellular | 17 |
cd and nmr | 17 |
at physiological ph | 17 |
binding sites for | 17 |
the protein in | 17 |
of the bacterial | 17 |
the training set | 17 |
methods for the | 17 |
that the presence | 17 |
the interplay between | 17 |
modulation of the | 17 |
was found in | 17 |
there was a | 17 |
an amino acid | 17 |
of this peptide | 17 |
on the analysis | 17 |
can be a | 17 |
were found in | 17 |
seq x and | 17 |
analysis showed that | 17 |
determined by nmr | 17 |
for the analysis | 17 |
the asymmetric unit | 17 |
motion of the | 17 |
the full length | 17 |
the last years | 17 |
work we have | 17 |
islet amyloid polypeptide | 17 |
acids in the | 17 |
by measuring the | 17 |
important roles in | 17 |
antimicrobial activity of | 17 |
for their ability | 17 |
was performed by | 17 |
developed a novel | 17 |
the development and | 17 |
the peptide was | 17 |
the membrane surface | 17 |
terms of the | 17 |
play a key | 17 |
been associated with | 17 |
degrees of freedom | 17 |
the accumulation of | 17 |
is necessary for | 17 |
target for the | 17 |
these results indicate | 17 |
is a protein | 17 |
of a ligand | 17 |
the monte carlo | 17 |
the method of | 17 |
away from the | 17 |
the region of | 17 |
a glutamic acid | 17 |
and the number | 17 |
the recognition of | 17 |
determined by x | 17 |
is followed by | 17 |
able to interact | 17 |
ranging from to | 17 |
and secondary structure | 17 |
results on the | 17 |
an essential role | 17 |
a single protein | 17 |
modeling of the | 17 |
using nmr spectroscopy | 17 |
of drug discovery | 17 |
our results indicate | 17 |
is part of | 17 |
expressed in the | 17 |
new insights into | 17 |
studies revealed that | 17 |
the coupling of | 17 |
in the outer | 17 |
sequences in the | 17 |
known that the | 17 |
not yet been | 17 |
the template and | 17 |
of the biological | 17 |
protein folding and | 17 |
the functions of | 17 |
the protein to | 17 |
to our knowledge | 17 |
produced by the | 17 |
molecules have been | 17 |
a lot of | 17 |
have the ability | 17 |
of rna molecules | 17 |
of the mechanism | 17 |
also been used | 17 |
can be done | 17 |
are difficult to | 17 |
rna structure prediction | 17 |
we designed a | 17 |
results of this | 17 |
residues at the | 17 |
aim was to | 17 |
is used as | 17 |
peptides can be | 17 |
in the current | 17 |
the most stable | 17 |
in cancer cells | 17 |
studies were performed | 17 |
binding to a | 17 |
integral membrane proteins | 17 |
the advantage of | 17 |
we are currently | 17 |
amino group of | 17 |
of the disulfide | 17 |
models of the | 17 |
number of protein | 17 |
in real time | 17 |
well as a | 17 |
modifi cation of | 17 |
of the actin | 17 |
circular dichroism and | 17 |
is critical for | 17 |
the usefulness of | 17 |
a study of | 17 |
each amino acid | 17 |
of the virion | 17 |
the site of | 17 |
that the two | 17 |
there have been | 17 |
we are able | 17 |
d structural data | 16 |
was based on | 16 |
to mimic the | 16 |
a lipid bilayer | 16 |
of the total | 16 |
are interested in | 16 |
this indicates that | 16 |
with those of | 16 |
the last decade | 16 |
expression of the | 16 |
is the major | 16 |
a very high | 16 |
structural changes in | 16 |
to the fact | 16 |
because they are | 16 |
and mechanism of | 16 |
domain and the | 16 |
in the hydrophobic | 16 |
that the number | 16 |
to establish the | 16 |
comparable to that | 16 |
in determining the | 16 |
to address the | 16 |
fold into a | 16 |
allows for the | 16 |
carried out to | 16 |
the intrinsically disordered | 16 |
of the pore | 16 |
are considered to | 16 |
electrostatic interactions between | 16 |
kagome lattice structure | 16 |
as a basis | 16 |
and the corresponding | 16 |
in the synthesis | 16 |
tools for the | 16 |
in the complex | 16 |
regions in the | 16 |
and compared with | 16 |
described in the | 16 |
elements in the | 16 |
have been widely | 16 |
order to identify | 16 |
sensitivity and selectivity | 16 |
can be studied | 16 |
independent of the | 16 |
to the binding | 16 |
of the process | 16 |
of sequences and | 16 |
of nucleic acid | 16 |
xu et ai | 16 |
structure can be | 16 |
the replacement of | 16 |
enabled us to | 16 |
with the binding | 16 |
was confirmed by | 16 |
in such a | 16 |
study on the | 16 |
and it was | 16 |
and as a | 16 |
potent inhibitors of | 16 |
on solid support | 16 |
approach based on | 16 |
active site and | 16 |
broad spectrum of | 16 |
the selected compounds | 16 |
a homology model | 16 |
in the secondary | 16 |
well known that | 16 |
high affinity for | 16 |
of the central | 16 |
expressed in e | 16 |
that the interaction | 16 |
the innate immune | 16 |
has emerged as | 16 |
of these molecules | 16 |
was achieved by | 16 |
the structural basis | 16 |
a protein with | 16 |
local structures and | 16 |
the decrease of | 16 |
may contribute to | 16 |
as an alternative | 16 |
study of a | 16 |
in protein structures | 16 |
formation of amyloid | 16 |
we have applied | 16 |
a neural network | 16 |
the structural features | 16 |
the knowledge of | 16 |
the proteins were | 16 |
binding site is | 16 |
are considered as | 16 |
are crucial for | 16 |
when compared with | 16 |
the scope of | 16 |
have been performed | 16 |
goal of this | 16 |
for this reason | 16 |
we have demonstrated | 16 |
of the sequences | 16 |
to be responsible | 16 |
of a particular | 16 |
should be noted | 16 |
the sequences of | 16 |
taking advantage of | 16 |
it is believed | 16 |
chemical properties of | 16 |
arrangement of the | 16 |
of the high | 16 |
virtual screening for | 16 |
to changes in | 16 |
peptide derived from | 16 |
an analysis of | 16 |
is found in | 16 |
because it is | 16 |
in the template | 16 |
peptides corresponding to | 16 |
emerged as a | 16 |
our aim is | 16 |
were performed using | 16 |
in an attempt | 16 |
on the nature | 16 |
contributes to the | 16 |
the difference between | 16 |
the content of | 16 |
contribution of the | 16 |
p and p | 16 |
in all cases | 16 |
play a crucial | 16 |
red blood cells | 16 |
of the channel | 16 |
involved in a | 16 |
a single molecule | 16 |
be noted that | 16 |
the protein chain | 16 |
implicated in the | 16 |
in the database | 16 |
a role for | 16 |
vivo and in | 16 |
an in silico | 16 |
may be the | 16 |
structure of this | 16 |
the catalytic site | 16 |
experimental and computational | 16 |
from the literature | 16 |
in water and | 16 |
the actin cytoskeleton | 16 |
structures of rna | 16 |
using circular dichroism | 16 |
the most abundant | 16 |
to be very | 16 |
as a novel | 16 |
order to find | 16 |
of the chemical | 16 |
of the e | 16 |
we study the | 16 |
of a structure | 16 |
could also be | 16 |
molecular mass of | 16 |
of proteins that | 16 |
discovery of novel | 16 |
we carried out | 16 |
of ion channels | 16 |
in the middle | 16 |
the thermal stability | 16 |
the peptide chain | 16 |
found in a | 16 |
activity of a | 16 |
of the h | 16 |
were studied by | 16 |
the binding to | 16 |
domains of the | 16 |
aim of our | 16 |
we have performed | 16 |
very similar to | 16 |
report on the | 16 |
of in vitro | 16 |
of the energy | 16 |
to the identification | 16 |
the integration of | 16 |
the behaviour of | 16 |
cell adhesion and | 16 |
a small molecule | 16 |
comparative analysis of | 16 |
in this region | 16 |
the delivery of | 16 |
selection of the | 16 |
can be explained | 16 |
affi nity and | 16 |
for the production | 16 |
aspects of the | 16 |
was suggested that | 16 |
the in silico | 16 |
been able to | 16 |
content of the | 16 |
explained by the | 16 |
logarithm of the | 16 |
at the cell | 16 |
extension of the | 16 |
for the determination | 16 |
it is likely | 16 |
are among the | 16 |
in a number | 16 |
ray crystal structure | 16 |
the results indicate | 16 |
before and after | 16 |
to confirm the | 16 |
we determined the | 16 |
t h e | 16 |
which could be | 16 |
is limited by | 16 |
it is still | 16 |
proportional to the | 16 |
number of different | 16 |
a list of | 16 |
comparative protein structure | 16 |
widely used for | 16 |
group of the | 16 |
alignment of the | 16 |
means of the | 16 |
recognition of the | 16 |
the transition state | 16 |
to define the | 15 |
a molecular level | 15 |
structure with a | 15 |
single molecule fluorescence | 15 |
of idps idprs | 15 |
have the same | 15 |
note that the | 15 |
the specifi c | 15 |
were investigated by | 15 |
understand the role | 15 |
among the most | 15 |
vast majority of | 15 |
the rational design | 15 |
specificity of the | 15 |
to the c | 15 |
report the synthesis | 15 |
of the coronavirus | 15 |
in this field | 15 |
of the presence | 15 |
have recently been | 15 |
application of this | 15 |
molecular biology and | 15 |
and a c | 15 |
important in the | 15 |
nmr structure of | 15 |
the solid phase | 15 |
of dna and | 15 |
the middle of | 15 |
of the current | 15 |
the vast majority | 15 |
contribution to the | 15 |
the venom of | 15 |
is stabilized by | 15 |
method was used | 15 |
by increasing the | 15 |
is an attractive | 15 |
the hydrophobic core | 15 |
tertiary structures of | 15 |
showing that the | 15 |
may be of | 15 |
order to improve | 15 |
or in the | 15 |
especially in the | 15 |
number of structures | 15 |
most of them | 15 |
of the fluorescence | 15 |
we decided to | 15 |
this protein is | 15 |
acid side chains | 15 |
is considered to | 15 |
high level of | 15 |
context of the | 15 |
inhibitory activity of | 15 |
the response of | 15 |
has been performed | 15 |
potent inhibitor of | 15 |
not only for | 15 |
as they are | 15 |
the composition of | 15 |
shed light on | 15 |
forms of the | 15 |
is to develop | 15 |
of the carbohydrate | 15 |
protein structure modeling | 15 |
monte carlo simulation | 15 |
of the chromophore | 15 |
our aim was | 15 |
a broad range | 15 |
they do not | 15 |
suggested to be | 15 |
nmr spectroscopy and | 15 |
early stages of | 15 |
used to assess | 15 |
and tertiary structures | 15 |
are located in | 15 |
of a human | 15 |
evidence suggests that | 15 |
the de novo | 15 |
impact on the | 15 |
is close to | 15 |
the electron beam | 15 |
absence of the | 15 |
new method for | 15 |
there are no | 15 |
study the effect | 15 |
a tree decomposition | 15 |
protein fold recognition | 15 |
of the trna | 15 |
physicochemical properties of | 15 |
the proteins in | 15 |
of ordered proteins | 15 |
of the self | 15 |
conformation of a | 15 |
structures that are | 15 |
the base of | 15 |
shown in table | 15 |
disruption of the | 15 |
the comparison of | 15 |
supported by a | 15 |
root mean square | 15 |
with the experimental | 15 |
widely used in | 15 |
discussed in the | 15 |
developed a new | 15 |
is the only | 15 |
to form an | 15 |
influence of crystal | 15 |
of great interest | 15 |
is very important | 15 |
that in the | 15 |
a serine protease | 15 |
is shown that | 15 |
at atomic resolution | 15 |
conformational preferences of | 15 |
analyses of the | 15 |
of molecular biology | 15 |
able to inhibit | 15 |
the fi nal | 15 |
the severe acute | 15 |
power of the | 15 |
docking and scoring | 15 |
applications of the | 15 |
an antimicrobial peptide | 15 |
molecule in the | 15 |
this method is | 15 |
c and c | 15 |
level of the | 15 |
an alternative to | 15 |
the antimicrobial activity | 15 |
amber force field | 15 |
molecular dynamics and | 15 |
chains of the | 15 |
the drug discovery | 15 |
able to detect | 15 |
be attributed to | 15 |
a tool for | 15 |
to design a | 15 |
known to bind | 15 |
of the best | 15 |
using molecular dynamics | 15 |
the y e | 15 |
protein of interest | 15 |
necessary for the | 15 |
in our previous | 15 |
taken from the | 15 |
to the native | 15 |
a long time | 15 |
of the results | 15 |
to generate the | 15 |
from the venom | 15 |
investigate the effect | 15 |
to form amyloid | 15 |
to the structural | 15 |
listed in table | 15 |
structures based on | 15 |
showed that a | 15 |
of the basic | 15 |
our data suggest | 15 |
in the final | 15 |
time of the | 15 |
charge of the | 15 |
is compatible with | 15 |
in solution and | 15 |
for design of | 15 |
the presence and | 15 |
are needed to | 15 |
residues that are | 15 |
detected in the | 15 |
the folding process | 15 |
regulated by the | 15 |
giant unilamellar vesicles | 15 |
then used to | 15 |
to distinguish between | 15 |
the partition coefficient | 15 |
result of the | 15 |
critical for the | 15 |
representation of the | 15 |
of the guest | 15 |
which leads to | 15 |
the stabilization of | 15 |
the intensity of | 15 |
evidence for a | 15 |
of which is | 15 |
one of its | 15 |
protein interactions and | 15 |
with the highest | 15 |
we designed and | 15 |
volume of the | 15 |
occur in the | 15 |
to atomic resolution | 15 |
temperature dependence of | 15 |
to a protein | 15 |
from the same | 15 |
in our work | 15 |
the family of | 15 |
functional properties of | 15 |
higher than the | 15 |
of these methods | 15 |
the negatively charged | 15 |
of the ribosome | 15 |
has been solved | 15 |
the maintenance of | 15 |
and mass spectrometry | 15 |
to search for | 15 |
critical assessment of | 15 |
was isolated from | 15 |
with the target | 15 |
the onset of | 15 |
to follow the | 15 |
of the plant | 15 |
the aggregation process | 15 |
proteins from the | 15 |
with experimental data | 15 |
natural amino acids | 15 |
atoms in the | 15 |
value of the | 15 |
the endoplasmic reticulum | 15 |
can be classified | 15 |
this is due | 14 |
of severe acute | 14 |
even in the | 14 |
so as to | 14 |
such as those | 14 |
have been successfully | 14 |
the advantages of | 14 |
tested in vitro | 14 |
of physical chemistry | 14 |
to the corresponding | 14 |
the proliferation of | 14 |
identification of novel | 14 |
of sequence and | 14 |
widely used to | 14 |
destabilization of the | 14 |
the g protein | 14 |
of patients with | 14 |
models have been | 14 |
and the ability | 14 |
structures determined by | 14 |
of conformational changes | 14 |
of the side | 14 |
to the discovery | 14 |
than of the | 14 |
results will be | 14 |
and at the | 14 |
the success of | 14 |
stability of these | 14 |
introduced into the | 14 |
in all the | 14 |
is controlled by | 14 |
and formation of | 14 |
and application of | 14 |
and they are | 14 |
were performed to | 14 |
structure of sars | 14 |
been reported to | 14 |
was observed that | 14 |
identified as a | 14 |
ray structure of | 14 |
contact with the | 14 |
the protein was | 14 |
new family of | 14 |
lies in the | 14 |
instead of the | 14 |
to be in | 14 |
variety of biological | 14 |
in this presentation | 14 |
we have to | 14 |
in biological systems | 14 |
and the n | 14 |
conversion of the | 14 |
but also in | 14 |
the folding and | 14 |
step of the | 14 |
used to generate | 14 |
in the rna | 14 |
amino acid with | 14 |
protein to the | 14 |
may play a | 14 |
analogues of the | 14 |
we hypothesize that | 14 |
a collection of | 14 |
biological activity and | 14 |