bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
spike protein	1287
respiratory syndrome	1275
acute respiratory	1206
severe acute	1080
syndrome coronavirus	898
novel coronavirus	887
amino acid	852
cord uid	702
doc id	702
biorxiv doi	701
gene expression	615
cell types	521
immune response	511
epithelial cells	503
coronavirus disease	475
sars coronavirus	450
receptor binding	440
binding domain	422
spike glycoprotein	414
performed using	404
neutralizing antibodies	396
viral rna	392
viral replication	374
host cell	372
human ace	371
infected cells	363
converting enzyme	353
type i	346
room temperature	332
virus infection	331
immune responses	329
viral infection	324
amino acids	321
supplementary table	317
innate immune	308
cell entry	307
binding affinity	300
extended data	292
coronavirus spike	287
severe covid	287
viral genome	281
ace receptor	277
molecular dynamics	273
crystal structure	272
previously described	266
single cell	264
rna viruses	264
cell lines	262
ace expression	262
cell type	260
binding site	255
influenza virus	252
new coronavirus	251
antiviral activity	250
seq data	245
nucleic acid	244
sequencing data	243
vero cells	237
middle east	234
host cells	233
active site	231
endothelial cells	230
neutralizing antibody	229
viral entry	228
secondary structure	227
machine learning	222
cell rna	219
human sars	218
cleavage site	217
mg kg	216
cell culture	212
infectious diseases	212
east respiratory	212
sequence alignment	211
thermo fisher	209
monoclonal antibodies	209
structural basis	208
immune system	206
public health	206
virus replication	203
rna polymerase	203
electron microscopy	199
human coronavirus	197
cell line	195
viral proteins	194
cell epitopes	194
spike proteins	192
mg ml	190
clinical trials	190
structural proteins	189
epi isl	188
cell receptor	186
em structure	182
cytokine storm	181
stem cells	181
previous studies	181
flow cytometry	180
taken together	180
viral load	179
orf ab	179
free energy	178
differentially expressed	176
highly conserved	175
respiratory tract	174
closely related	173
wild type	171
respiratory disease	166
clinical samples	164
genome sequences	163
ng ml	163
human lung	162
results suggest	162
rna virus	161
membrane fusion	160
bat cov	159
cell responses	159
sars cov	158
cell surface	158
immune cells	156
protease inhibitor	156
mm nacl	156
human coronaviruses	156
large number	155
rna sequencing	155
reverse transcription	155
lung injury	153
total number	152
binding sites	152
cov spike	152
present study	150
viral infections	149
disease severity	149
negative control	148
previously reported	148
protein structure	148
protein interaction	147
reference genome	147
data analysis	147
respiratory distress	146
coronavirus infection	145
ace binding	144
two different	144
statistically significant	144
positive control	144
ebola virus	143
md simulations	143
phylogenetic tree	143
positive selection	142
peripheral blood	142
well plates	141
whole genome	141
hydrogen bonds	140
human respiratory	139
receptor ace	138
bat origin	138
time points	137
least one	137
mass spectrometry	136
animal models	136
pdb id	135
vaccine development	135
expressed genes	135
target cells	134
cell death	134
kcal mol	134
way anova	133
authors declare	133
may also	132
results indicate	131
protein expression	131
stem cell	131
deep learning	131
fisher scientific	131
i interferon	130
zika virus	130
monoclonal antibody	130
multiple sequence	129
main protease	129
antibody responses	128
world health	128
differential expression	127
human monoclonal	127
class i	127
codon usage	126
human cells	126
high levels	125
protein interactions	125
expression levels	125
terminal domain	124
stranded rna	124
virus entry	124
rna extraction	123
mouse model	123
enrichment analysis	123
airway epithelial	123
phylogenetic analysis	123
rhesus macaques	122
calculated using	122
basal cells	122
determine whether	121
pneumonia outbreak	121
distress syndrome	121
conformational changes	120
inflammatory cytokines	120
inflammatory response	120
probable bat	120
transcription factor	120
severe disease	120
generated using	120
significantly higher	119
innate immunity	119
protein sequences	118
lung cells	118
health organization	118
data sets	117
protein sequence	117
significant differences	116
ace protein	116
prefusion conformation	116
standard deviation	115
systematic review	115
viral genomes	115
human airway	115
dependent rna	115
coronavirus associated	114
infectious disease	114
receptor recognition	114
outbreak associated	114
like protease	114
see methods	114
generation sequencing	113
even though	113
gene set	113
mm tris	113
plasma membrane	113
united states	113
analysis revealed	113
antibody response	112
force field	111
nucleocapsid protein	111
error bars	110
days post	110
web server	109
entry depends	109
clinical characteristics	108
data set	108
rna synthesis	108
sequence identity	107
clinically proven	107
sialic acid	107
cov infection	106
statistical analysis	106
dendritic cells	106
described previously	106
also observed	105
final concentration	105
total rna	105
see table	105
drug repurposing	105
epithelial cell	104
highly expressed	103
acid residues	103
endoplasmic reticulum	103
proven protease	103
publicly available	102
positive cells	102
genome sequencing	102
expression data	101
fold change	101
patients infected	101
host immune	101
coronavirus sars	100
data collection	100
three times	100
kenyon cells	100
reference sequence	100
protein structures	100
high affinity	100
genomic rna	100
viral particles	100
neural networks	100
widely used	99
small molecule	99
spike receptor	99
analyzed using	99
nucleic acids	99
data suggest	98
mhc class	98
fusion protein	98
sequence data	98
human genome	98
acid sequence	98
important role	98
global health	97
bovine serum	97
growth factor	97
competing interests	97
synonymous mutations	97
per well	96
drug discovery	96
immunodeficiency virus	96
statistical significance	95
genome sequence	95
ncov spike	95
recent study	94
transcription factors	94
made available	93
hydrogen bond	93
crystal structures	93
time series	93
type ii	93
also found	93
hospitalized patients	92
pl pro	91
copy number	91
mutation rate	91
open reading	91
specific antibodies	90
minor variants	89
dynamics simulations	89
cell membrane	89
previous study	89
quality control	89
angiotensin converting	89
single nucleotide	89
vaccine candidate	89
dna methylation	88
cell cycle	88
expression analysis	88
first step	87
cell populations	87
results show	86
two distinct	86
risk factors	86
wide range	86
surface area	86
three different	86
viral spike	85
reading frame	85
dependent manner	85
current study	85
approved drugs	85
host response	85
clinical features	84
hepatitis virus	84
small molecules	84
rna genome	84
cells expressing	83
binding motifs	83
adipose tissue	83
infectious virus	83
ct values	83
lung tissue	83
related coronavirus	83
cytopathic effect	83
human immunodeficiency	83
lysis buffer	82
culture medium	82
cell differentiation	82
ms ms	82
molecular weight	82
cleavage sites	82
immune repertoire	82
infected mice	81
experimental data	81
furin cleavage	81
accessory calyx	81
vaccine design	80
time pcr	80
host proteins	80
time rt	80
alveolar macrophages	80
enveloped viruses	79
binding motif	79
memory cd	79
immune cell	79
allowed us	79
time point	79
infected patients	79
raw data	79
glucose uptake	79
single cells	79
viral protein	79
bat sars	79
gene ontology	79
structure prediction	78
binding free	78
i ifn	78
positive samples	78
results showed	78
human cell	78
mrna expression	77
full length	77
respiratory viruses	77
respiratory syncytial	77
inflammatory responses	77
virus particles	77
cells using	77
plaque assay	77
magnetic stimulation	77
protease inhibitors	77
acid sequences	76
heavy chain	76
nsp protein	76
confirmed cases	76
ace cells	76
neural network	76
immune evasion	76
high throughput	76
serine protease	75
recent studies	75
whole blood	75
determined using	75
cell immunity	75
mm hepes	75
spectrum antiviral	75
copyright holder	74
real time	74
significant difference	74
structure determination	74
global pandemic	74
signaling pathway	74
side chain	73
convalescent plasma	73
data bank	73
urgent need	73
nervous system	73
post infection	73
cd cd	72
viral loads	72
graphpad prism	72
genomic dna	72
cell viability	72
membrane protein	71
higher levels	71
commonly used	71
body weight	71
cell response	71
dna sequences	71
syncytial virus	71
author funder	71
functional receptor	71
lung epithelial	71
western blot	71
orf protein	70
protein data	70
virus type	70
antibody binding	70
physical activity	70
envelope protein	70
sample size	70
network analysis	70
protein binding	70
different types	70
drug design	70
commercially available	70
see supplementary	70
structural studies	70
mouse hepatitis	70
class ii	70
also identified	70
life cycle	70
well plate	70
viral input	69
multiplex pcr	69
genes involved	69
drug targets	69
associated genes	69
tmprss expression	69
specific cd	69
sequence similarity	69
molecular docking	69
master mix	69
transgenic mice	69
across different	69
human population	69
pcr assays	68
better understand	68
significantly lower	68
biological processes	68
expression patterns	68
coronavirus replication	68
van der	68
dorsal accessory	68
dna polymerase	68
cov nsp	68
acute lung	68
primary human	68
human protein	68
type diabetes	68
proteolytic cleavage	68
hours post	67
escherichia coli	67
biorxiv preprint	67
previous work	67
ligand binding	66
cell activation	66
multiple comparisons	66
future studies	66
flow rate	66
antiviral drug	66
viral envelope	66
day post	66
genetic information	66
based approach	66
obtained using	66
copies ml	66
may provide	66
expression level	65
target genes	65
binding mode	65
dengue virus	65
pulmonary surfactant	65
relatively high	65
reverse transcriptase	65
cell epitope	65
pathway analysis	65
transcranial magnetic	65
er stress	65
high level	65
structural analysis	65
adaptive immune	65
inhibitory activity	65
antibody titers	65
reading frames	64
sustentacular cells	64
thermofisher scientific	64
secondary structures	64
supplementary material	64
least two	64
per sample	64
library preparation	64
blood samples	64
bone marrow	64
cytokine production	64
clinical trial	63
rbd protein	63
binding pocket	63
data processing	63
type iii	63
molecular mechanisms	63
high expression	63
significantly reduced	63
ge healthcare	63
related genes	63
secondary antibodies	63
neutralizing activity	63
data indicate	63
maximum likelihood	63
drug development	63
false positive	62
also known	62
strand rna	62
cells per	62
animal species	62
marker genes	62
alveolar epithelial	62
measured using	62
binding interface	62
binding protein	62
rbd ace	62
genome coverage	62
specific antibody	62
host factors	61
virus infections	61
binding affinities	61
much higher	61
mutation rates	61
human igg	61
like receptor	61
binding domains	61
antiviral drugs	61
first time	61
binding proteins	61
also showed	61
fold higher	60
next generation	60
also used	60
pluripotent stem	60
increased expression	60
independent experiments	60
human transmission	60
anp high	60
length human	60
supplemental table	60
genetic diversity	60
intrinsic disorder	60
ic values	60
hydrophobic interactions	60
better understanding	60
critical role	60
rbd domain	60
cell proliferation	60
human proteins	59
set enrichment	59
rna secondary	59
expressing cells	59
human tissues	59
accession number	59
adj gla	59
bat coronavirus	59
vaccine candidates	59
new england	59
ex vivo	59
cell population	59
smooth muscle	59
serial dilutions	59
significantly different	59
fetal bovine	58
cell data	58
genomic sequences	58
using human	58
may contribute	58
igg antibodies	58
may play	58
reference sequences	58
domain bound	58
disease progression	58
spike rbd	58
ace complex	58
protein kinase	58
bp kenyon	58
spinal cord	58
ros production	58
protein complex	58
animal model	58
ace interaction	57
potent neutralizing	57
protective immunity	57
seq analysis	57
inhibit sars	57
isothermal amplification	57
tissue culture	57
fusion peptide	57
ace interface	57
disease map	57
modern hopfield	57
expression profiles	57
influenza viruses	57
bars represent	57
secondary antibody	57
data using	57
differential gene	57
hierarchical clustering	57
drosophila melanogaster	57
secondary site	57
progenitor cells	57
sample preparation	57
likely due	56
rbd binding	56
attention mechanism	56
rna replication	56
coding sequences	56
weight loss	56
applied biosystems	56
cohort study	56
mrna levels	56
human angiotensin	56
high quality	56
antiviral response	56
crispr cas	56
cell atlas	56
firing rates	56
data points	56
soluble ace	56
cancer cells	56
component analysis	56
large scale	55
including sars	55
treated cells	55
two major	55
results demonstrate	55
chain reaction	55
two independent	55
comparative analysis	55
olfactory bulb	55
highly pathogenic	55
different cell	55
relative abundance	55
water molecules	55
per ml	55
pfu ml	54
coding region	54
antiviral effect	54
international license	54
allows us	54
virus genome	54
much lower	54
findings suggest	54
genomic characterisation	54
lexical stress	54
airway epithelium	54
genomic diversity	54
patient samples	54
analysis showed	54
serum samples	54
human pancreatic	53
th cells	53
previous reports	53
two groups	53
lung cancer	53
low levels	53
supplementary file	53
complete genome	53
cell subsets	53
significant increase	53
recombinant protein	53
results obtained	52
using two	52
causative agent	52
phage display	52
related coronaviruses	52
human host	52
pcr amplification	52
per cell	52
fatty acid	52
rna interference	52
default parameters	52
nucleotide sequences	52
disease outbreaks	52
ciliated cells	52
relatively low	52
also detected	52
bulk rna	52
one hour	52
several studies	52
hace mice	51
common cold	51
based vaccine	51
trimeric spike	51
sequence analysis	51
signal peptide	51
pcr products	51
base pairs	51
assessed using	51
signaling pathways	51
mammalian cells	51
virus origins	51
polymerase chain	51
standard error	51
ace tmprss	51
fluorescent protein	51
repertoire classification	50
global initiative	50
analysis using	50
transmembrane domain	50
saudi arabia	50
high pmn	50
key role	50
ace gene	50
fatality rate	50
viral titers	50
em structures	50
md simulation	50
molecular biology	50
recombination events	50
previously shown	50
high viral	50
cell growth	50
ribosome profiling	50
body temperature	50
currently available	50
protein synthesis	50
fatty acids	50
spike igg	50
based assay	50
potential therapeutic	50
associated coronavirus	50
previously published	50
influenza infection	50
paneth cell	50
biological replicates	50
peer review	49
prostate cancer	49
culture supernatants	49
rna binding	49
drug candidates	49
ace microbody	49
cells infected	49
male mice	49
visualized using	49
viral genomic	49
significantly increased	49
cleavage activity	49
tryptic peptides	49
viral infectivity	49
luciferase activity	49
analysis based	49
recombinant sars	49
olfactory epithelium	49
based methods	49
buffer containing	49
binding residues	49
infected individuals	49
control mice	49
cell cultures	49
reads per	49
highly sensitive	49
ucsf chimera	49
hopfield networks	49
genes associated	49
done using	49
throughput sequencing	48
goat anti	48
significant effect	48
wash buffer	48
processed using	48
buffered saline	48
protein complexes	48
host protein	48
foot placement	48
see also	48
allele frequency	48
virus rna	48
influenza data	48
emerging infectious	48
school health	48
control group	48
england biolabs	48
sample collection	48
mononuclear cells	48
read depth	48
clinical course	48
stop codon	48
principal component	48
central nervous	47
step rt	47
side chains	47
mice infected	47
million people	47
right panel	47
highly variable	47
gene sets	47
like particles	47
stress response	47
life technologies	47
emerging coronaviruses	47
upper respiratory	47
acid substitutions	47
ko mice	47
washed twice	47
pancreatic islets	47
cov ratg	47
corona virus	47
cystic fibrosis	47
caenorhabditis elegans	47
cells via	47
sequencing reads	47
peptide vaccine	47
current pandemic	47
lower respiratory	47
link prediction	47
neutralization assay	47
endothelial cell	47
coronavirus infections	47
amplicon sequencing	47
nucleotide sequence	47
accessory proteins	47
gold standard	46
olfactory sensory	46
motor cortex	46
primary antibodies	46
mhc i	46
effect size	46
zar orthologs	46
sensory neurons	46
may lead	46
protein level	46
also shown	46
nonstructural protein	46
disease control	46
log fold	46
healthy donors	46
health services	46
vesicular stomatitis	46
copy numbers	46
angiotensin ii	46
san diego	45
genome replication	45
human primates	45
quantified using	45
human genes	45
respiratory virus	45
phylogenetic trees	45
health emergency	45
high resolution	45
critically ill	45
multiple sclerosis	45
molecular mechanism	45
protease tmprss	45
ion channel	45
fold increase	45
nasopharyngeal swabs	45
specific cell	45
cov orf	45
cancer cell	45
recently reported	45
aged mice	45
protein levels	45
health care	45
magnetic beads	45
fluorescence intensity	45
malayan pangolins	45
respiratory failure	45
blood mononuclear	45
small number	45
negative controls	45
low viral	45
infected animals	45
zikv infection	44
virus neutralization	44
viral sequences	44
salt bridges	44
mouse models	44
tmprss cells	44
target protein	44
sino biological	44
sybr green	44
immune receptor	44
peptide pools	44
light chain	44
serially diluted	44
terminal region	44
enhanced rnai	44
severe respiratory	44
membrane proteins	44
cell fusion	44
highly similar	43
genomic data	43
therapeutic targets	43
also tested	43
drug target	43
cell receptors	43
treg cells	43
protein folding	43
interferon response	43
african green	43
binding energy	43
broadly neutralizing	43
test whether	43
inflammatory cytokine	43
different countries	43
expression profiling	43
clonal variants	43
severe patients	43
host receptor	43
nlrp inflammasome	43
molecular basis	43
proximal origin	43
across multiple	43
stomatitis virus	43
herpes simplex	43
electron density	43
free energies	43
coronavirus genome	43
bronchoalveolar lavage	43
randomly selected	43
primary site	43
new york	43
novel human	42
chadox ncov	42
primer set	42
neutralize sars	42
transmission dynamics	42
identified using	42
viral copies	42
natural language	42
inhibitory effect	42
interaction map	42
orf proteins	42
swab samples	42
species transmission	42
structural biology	42
blood cells	42
three independent	42
cellular entry	42
adaptive immunity	42
bd biosciences	42
standard deviations	42
supplementary information	42
previously identified	42
potential role	42
affinity maturation	42
linear regression	42
ifn signaling	42
similar results	42
nonsynonymous mutations	42
open source	42
cov rbd	42
angiotensin system	42
downstream analysis	41
viral shedding	41
igg liposomes	41
domestic cats	41
genes proteins	41
structural protein	41
oxidative stress	41
gap junctions	41
muscle cells	41
cell clusters	41
express ace	41
induced lung	41
low frequency	41
point mutations	41
cm long	41
current covid	41
healthy controls	41
potential drug	41
transmembrane protein	41
conserved residues	41
mm edta	41
secretory cells	41
essential role	41
evolutionary history	41
host genomic	41
lymph nodes	41
mechanical ventilation	41
fastq files	41
case study	41
gisaid database	41
false discovery	41
discovery rate	41
electrostatic interactions	41
high degree	41
cell sequencing	41
convolutional neural	41
ace mrna	41
antiviral effects	41
antigen presentation	41
viral receptor	41
natural selection	41
life history	41
different concentrations	41
iav infection	41
coronavirus nsp	41
expression pattern	41
using different	41
inflammatory bowel	40
epitope prediction	40
human serum	40
primer probe	40
population size	40
expression system	40
image analysis	40
expression vector	40
cells within	40
detected using	40
copies per	40
may affect	40
humoral immune	40
human neutralizing	40
lung inflammation	40
higher affinity	40
salt bridge	40
new insights	40
saccharomyces cerevisiae	40
human brain	40
nonstructural proteins	40
insulin secretion	40
novel sars	40
logistic regression	40
exclusion chromatography	40
beat gesture	40
also performed	40
hela cells	40
membrane vesicles	40
supplementary data	40
high sensitivity	40
protein trimer	40
genetic variants	40
sexual selection	40
related viruses	40
small intestine	40
domain complexed	40
two separate	40
receptor usage	40
nasopharyngeal swab	40
human pluripotent	40
antiviral responses	40
purifying selection	40
deep sequencing	40
viral pathogenesis	40
mm mgcl	40
mortality rate	39
kidney injury	39
spike glycoproteins	39
rna isolation	39
drug resistance	39
statistical analyses	39
blood flow	39
systems biology	39
tissue distribution	39
three viruses	39
dn ds	39
tree shrew	39
structural features	39
molecular simulations	39
interferon signaling	39
clinical outcomes	39
two types	39
cells well	39
learning methods	39
control samples	39
national institutes	39
cov replication	39
tcr signaling	39
remains unclear	39
fusion proteins	39
analysis tools	39
mechanisms underlying	39
increases infectivity	39
high specificity	39
broad spectrum	39
based drug	39
sense rna	39
healthy individuals	39
false positives	39
well known	39
exact test	39
fusion conformation	39
tree shrews	39
broad range	39
significantly enriched	38
raw sequencing	38
serum albumin	38
evoked potentials	38
immunosequencing data	38
distance matrix	38
fda approved	38
text mining	38
may explain	38
domain antibodies	38
two proteins	38
supplementary tables	38
medium containing	38
clinical studies	38
based analysis	38
standard curve	38
outer membrane	38
control cells	38
coronavirus nucleocapsid	38
study also	38
bronchial epithelial	38
virus detection	38
glycan shield	38
severe pneumonia	38
climate change	38
breast cancer	38
primer sequences	38
version posted	38
host interaction	38
coronavirus rna	38
tissue samples	38
many different	38
also show	38
crucial role	38
data demonstrate	38
positive controls	38
dp mice	38
consensus sequence	38
immune status	38
ace structure	38
public clones	38
animal care	38
tissue sections	38
calculated based	38
host range	38
electron microscope	37
simplex virus	37
grid search	37
sequences using	37
starting point	37
extracellular matrix	37
nsp proteins	37
host defense	37
conserved across	37
lower levels	37
molecular clock	37
thermo scientific	37
sequence homology	37
convalescent subjects	37
training set	37
first two	37
therapeutic options	37
reverse genetics	37
protein secondary	37
mep amplitude	37
naturally occurring	37
gene regulatory	37
lung pathology	37
surface glycoprotein	37
assay using	37
conformational dynamics	37
hong kong	37
necrosis factor	37
false negatives	37
host antiviral	37
domestic animals	37
functional characterization	37
rna expression	37
respiratory system	37
phylogenetic analyses	37
systematic reviews	37
national center	37
heparan sulfate	37
expression profile	37
one sample	37
constructed using	37
heptad repeat	37
neutralization activity	37
functional basis	37
airway epithelia	36
normal mode	36
post hoc	36
transmission electron	36
immune activation	36
viral evolution	36
virus evolution	36
coronavirus entry	36
solvent accessibility	36
genes encoding	36
learning models	36
human lungs	36
bowel disease	36
gene assay	36
antiviral immune	36
control animals	36
rna structure	36
inflamed lungs	36
side effects	36
whitney test	36
cultured cells	36
viral transmission	36
highly specific	36
cell identity	36
using graphpad	36
national institute	36
therapeutic potential	36
studies using	36
asked whether	36
comparisons test	36
hla class	36
stromal cells	36
infected pneumonia	36
computing platform	36
canonical autophagy	36
em maps	36
spreader nodes	36
time course	36
heart failure	36
outgroup aversion	36
may serve	36
hek cells	36
recently emerged	36
human receptor	36
cell signaling	36
domestic cat	36
viral genes	36
cells treated	36
coding regions	36
cell lysates	36
implanted signals	36
subunit vaccine	36
virus particle	36
escape mutants	36
immune signaling	35
green monkey	35
pattern recognition	35
avian influenza	35
viral fusion	35
transport medium	35
alertness level	35
visual cortex	35
free water	35
cell analysis	35
rbd proteins	35
viral membrane	35
mushroom body	35
protein function	35
donut pcr	35
pathway enrichment	35
two days	35
limited number	35
injured lungs	35
bioconductor package	35
one week	35
negatively charged	35
virus genomes	35
vast majority	35
two weeks	35
age groups	35
positively charged	35
internal control	35
poorly understood	35
direct contact	35
hpiv pref	35
tumor necrosis	35
disease caused	35
genomic regions	35
network inference	35
washed three	35
left panel	35
software package	35
therapeutic strategies	35
der waals	35
verso step	35
pv ihucovid	35
viral quasispecies	35
immune receptors	35
highly potent	35
transport media	35
mediated isothermal	35
ace isoforms	35
antiviral agents	35
analysis reveals	35
different species	35
nucleotide polymorphisms	35
smoking status	35
findings indicate	35
specific igg	35
consensus sequences	35
liquid nitrogen	35
predicted using	35
informed consent	34
higher expression	34
negative samples	34
ncbi database	34
early stage	34
culture supernatant	34
may represent	34
hcl ph	34
data science	34
reactive oxygen	34
potential vaccine	34
genetic data	34
taq dna	34
human populations	34
diminazene aceturate	34
rna sequences	34
two mutations	34
viral life	34
representation learning	34
aligned using	34
positive results	34
language processing	34
gel electrophoresis	34
spike ectodomain	34
protein family	34
study provides	34
viral strains	34
statistical computing	34
ray crystal	34
vehicle control	34
spike trimer	34
cell suspensions	34
close proximity	34
size exclusion	34
model building	34
cardiovascular disease	34
cmv dataset	34
raw reads	34
ribosomal frameshifting	34
paneth cells	34
approved drug	34
rna levels	34
new species	34
principal components	34
person transmission	34
interaction networks	34
ii iii	34
supplementary methods	34
muc ac	34
saliva samples	34
clinical data	34
virus strains	34
pseudotyped virus	34
autoimmune diseases	34
signal transduction	34
map reveals	34
ill patients	33
lung tissues	33
reads mapping	33
second syllable	33
intestinal epithelial	33
cohesin genes	33
throughput screening	33
less likely	33
mean square	33
will help	33
translation initiation	33
tested whether	33
infrequent events	33
beta cells	33
lateral protocerebrum	33
derived cms	33
human antibody	33
opioid receptors	33
genome copy	33
serological assays	33
tcid ml	33
acid detection	33
signalling pathway	33
first syllable	33
false negative	33
among different	33
drug administration	33
coding sequence	33
live virus	33
cynomolgus macaques	33
confidence interval	33
prefusion state	33
seq datasets	33
molar ratio	33
autistic traits	33
inhibit viral	33
hla alleles	33
rhesus macaque	33
intermediate hosts	33
increased risk	33
convalescent patients	33
pdb entry	33
correlation coefficient	33
treated mice	33
rabies virus	33
proteins involved	33
nasal cavity	33
thank dr	33
cell membranes	33
brain injury	33
data integration	33
human intestinal	33
functional analysis	33
cancer patients	33
membrane binding	33
sequence conservation	33
imaging system	33
gene regulation	33
alveolar cells	33
pandemic caused	33
viral rnas	33
human adult	33
main effect	33
current sars	33
recently published	33
average number	33
zebrafish larvae	33
pathogenic coronaviruses	33
protein solubility	33
organ failure	33
long structural	33
opioid receptor	32
based approaches	32
investigate whether	32
rapid detection	32
pcr reaction	32
female mice	32
risk factor	32
protein receptor	32
antiviral defense	32
root mean	32
virus receptor	32
pcr assay	32
input object	32
ace genes	32
like receptors	32
skeletal muscle	32
iii ifn	32
scientific community	32
common ancestor	32
drug repositioning	32
alertness levels	32
entry receptor	32
dna vaccine	32
worth noting	32
purified using	32
early stages	32
dendritic cell	32
infected cell	32
tailed amplicon	32
enabled us	32
cell fate	32
viral pneumonia	32
beat gestures	32
genomic characterization	32
host innate	32
delta opioid	32
mm long	32
first case	32
will also	32
conformational change	32
local resolution	32
antibodies targeting	32
enzymatic activity	32
confocal microscope	32
catalytic activity	32
binding pockets	32
based attention	32
high performance	32
assess whether	32
oxygen species	32
polymorphism ratios	32
generation times	32
global spread	32
genetic code	32
rna interactions	32
relatively small	32
clonal expansion	32
human disease	32
treg cell	32
cdc sars	32
virus titer	32
primary antibody	32
wide association	32
incubation period	32
seven days	32
human samples	32
selection pressure	32
may reflect	32
read alignment	32
biosafety level	32
many viruses	32
length sars	32
cdna synthesis	32
complex structure	32
situation report	32
wide variety	32
natural infection	32
alveolar type	32
therapeutic target	31
target dna	31
visualization system	31
scale bar	31
tcrb repertoire	31
tandem mass	31
spike antigen	31
signalling pathways	31
hace receptor	31
fusion state	31
dynamic range	31
spectral density	31
transgenic lines	31
pro cov	31
detection limit	31
co emissions	31
hot spots	31
urgently needed	31
trade liberalization	31
case fatality	31
sample sizes	31
agarose gel	31
based design	31
potent antiviral	31
tested positive	31
identify potential	31
host interactions	31
genomic epidemiology	31
stimulated gene	31
prefusion spike	31
image processing	31
lipid bilayer	31
four different	31
i interferons	31
specific memory	31
poly i	31
enveloped virus	31
dna sequencing	31
based method	31
previous findings	31
immune repertoires	31
three major	31
dna sequence	31
data also	31
low ph	31
clinical specimens	31
therapeutic development	31
protein rbd	31
wilcoxon rank	31
western blotting	31
taxonomic classification	31
data presented	31
brain endothelial	31
red blood	31
may cause	31
increasing concentrations	31
plasmodium falciparum	31
scale bars	31
per million	31
golden syrian	31
host gene	31
also examined	31
molecule inhibitors	31
mean value	31
located within	31
detect sars	31
nk cells	31
length spike	31
dependent enhancement	31
replication cycle	31
low quality	31
severe cases	31
frequency domain	31
basal cell	31
coronavirus pneumonia	31
like coronavirus	31
acid changes	31
transcriptional regulation	31
coronavirus receptor	30
north america	30
mutually exclusive	30
ct value	30
plaque assays	30
structural information	30
germinal center	30
mitotic centrosome	30
also assessed	30
million confirmed	30
plasma cells	30
life sciences	30
hubei province	30
viral titer	30
computational methods	30
hepes ph	30
disulfide bonds	30
positively selected	30
transcriptomic data	30
cell expression	30
virus hemagglutinin	30
sanger sequencing	30
virus spread	30
analysis shows	30
fever virus	30
normal human	30
infected samples	30
inflammasome activation	30
heat map	30
ribosomal rna	30
world data	30
seq reads	30
nuclear export	30
large numbers	30
hyperparameter search	30
whole brain	30
live sars	30
assay kit	30
actin cytoskeleton	30
results provide	30
supporting information	30
evaluated using	30
different time	30
convalescent individuals	30
abundance estimation	30
cell subtypes	30
molecular modeling	30
target proteins	30
reference genomes	30
two hours	30
cytokine release	30
anammox bacteria	30
ec values	30
mouse brain	30
novel method	30
human antibodies	30
gene lists	30
atomic model	30
next sought	30
robotic system	30
viral transport	30
untranslated region	30
may help	30
outer limbus	30
ace orthologs	30
default settings	30
also possible	30
nasal epithelial	30
spread across	30
adverse effects	30
mm imidazole	30
acquired using	30
ub organoid	30
magnetic resonance	30
coronaviridae family	30
pathogen detection	30
linked immunosorbent	30
pulmonary fibrosis	30
different viral	30
economic growth	30
synaptic scaling	30
sequencing depth	30
igg fc	30
cell transcriptomic	30
tissue damage	30
lavage fluid	30
one day	30
rank test	30
polymerase complex	29
binding assay	29
formic acid	29
wt mice	29
modified cdc	29
drives development	29
species severe	29
containing mm	29
vascular endothelial	29
central role	29
surface expression	29
cells express	29
stimulated genes	29
nsp complex	29
red line	29
rapid development	29
sequence embedding	29
accession id	29
least three	29
studies will	29
noise ratio	29
incubated overnight	29
viruses including	29
respiratory viral	29
retrospective cohort	29
data show	29
nile virus	29
syrian hamsters	29
per day	29
infected vero	29
viral gene	29
host genes	29
sequence motifs	29
rheumatoid arthritis	29
cortical representation	29
brain barrier	29
long term	29
per group	29
protein nsp	29
conformational states	29
inhibitors targeting	29
coronavirus papain	29
glucose homeostasis	29
lung cell	29
surface protein	29
next day	29
potent inhibitor	29
bl mice	29
virus transmission	29
convalescent sera	29
samples using	29
infection model	29
insect cells	29
polyclonal antibody	29
acid identity	29
alexa fluor	29
highly efficient	29
cysteine residues	29
wilcoxon signed	29
biotechnology information	29
positive sense	29
specific expression	29
driven entry	29
prepared using	29
diabetes mellitus	29
cell gene	29
sfv proteins	29
gap junction	29
interactive web	29
drug binding	29
human health	29
mouse igg	29
human bronchial	29
recently described	29
treated group	29
data suggests	29
west nile	29
shed light	29
excess proton	29
cells exposed	29
lung disease	29
biologically relevant	29
existing drugs	29
transfected cells	29
subcellular localization	29
santa fe	29
results also	29
protease cleavage	29
cytopathic effects	28
mhc ii	28
cpg force	28
igg mbcs	28
imbalanced host	28
response curves	28
research articles	28
model system	28
conserved among	28
conducted using	28
viral growth	28
goblet cells	28
may act	28
visual molecular	28
examined whether	28
network representation	28
surface plasmon	28
lesser extent	28
mitochondrial dysfunction	28
preliminary report	28
igg antibody	28
regulated genes	28
pearson correlation	28
start codons	28
latent space	28
blocking buffer	28
cold pbs	28
variable genes	28
molecular patterns	28
input sequences	28
coronavirus outbreak	28
biological functions	28
dipeptidyl peptidase	28
led us	28
respiratory infections	28
web portal	28
viral pathogens	28
resident memory	28
brain regions	28
tcr repertoire	28
biological samples	28
higher viral	28
infectious cdna	28
cell memory	28
antiviral activities	28
higher binding	28
intensive care	28
using either	28
cells ml	28
plasmon resonance	28
cellular immunity	28
antibody production	28
reads mapped	28
adj cpg	28
brain tissue	28
tms pulse	28
protein stability	28
duplex sequencing	28
protein production	28
showed high	28
using anti	28
significant decrease	28
protein domain	28
cell transcriptomics	28
human saliva	28
interaction network	28
high concentration	28
representative images	28
statistical tests	28
staphylococcus aureus	28
dose group	28
findings provide	28
cell suspension	28
cl pro	28
also included	28
possibly due	28
cellular immune	28
codon bias	28
mice showed	28
go terms	28
fusion core	28
closed state	28
analysis identified	28
binding regions	27
controlled trial	27
viral particle	27
data point	27
bound state	27
also revealed	27
associated molecular	27
highly enriched	27
much less	27
descriptive study	27
disease ecology	27
plant species	27
another study	27
entry factors	27
remains unknown	27
genbank accession	27
like coronaviruses	27
first reported	27
proinflammatory cytokines	27
hpv pmd	27
threshold value	27
thermal cycler	27
bioinformatics analysis	27
main orf	27
future work	27
dynamics simulation	27
pathogenic coronavirus	27
sum test	27
social distancing	27
changes induced	27
peptide sequences	27
physiological conditions	27
results support	27
treated animals	27
rna molecules	27
motor inhibition	27
population coverage	27
lung organoids	27
wpb size	27
structural data	27
close contact	27
mice immunized	27
showed higher	27
genome size	27
pneumonia associated	27
extraction step	27
positive patients	27
ctl epitopes	27
unexposed subjects	27
samples collected	27
learning rate	27
structural modeling	27
small animal	27
global public	27
will allow	27
therapeutic interventions	27
also reported	27
four times	27
antiviral therapy	27
virus survival	27
pangolin origin	27
high accuracy	27
different human	27
provide evidence	27
submucosal gland	27
studies suggest	27
genomic sequence	27
transgene silencing	27
adenovirus type	27
old mice	27
viral activity	27
viral attachment	27
data available	27
participants completed	27
vice versa	27
user interface	27
monte carlo	27
ongoing covid	27
oxford nanopore	27
lipid metabolism	27
preprint servers	27
ab initio	27
pcr system	27
fluorescence signal	27
disulfide bond	27
recombinant human	27
significant changes	27
viral clearance	27
probe sets	27
attention effect	27
rna editing	27
multiple testing	27
different tissues	26
silicon nitride	26
protein response	26
mini kit	26
culture media	26
interaction partners	26
veroe cells	26
enrichment score	26
potent inhibitors	26
contact tracing	26
mm na	26
different organs	26
reveals targets	26
clinical signs	26
cell survival	26
regulatory elements	26
success rate	26
lymph node	26
start codon	26
gene segments	26
memory cells	26
high risk	26
future research	26
conservation score	26
convergent evolution	26
familial cluster	26
closed conformation	26
fluorescence microscopy	26
stranded dna	26
mm sodium	26
acid residue	26
mm dtt	26
ang ii	26
pcr product	26
cov genome	26
significantly decreased	26
slightly higher	26
glycosylation sites	26
enr cd	26
emerging viruses	26
crystal violet	26
many studies	26
viral diseases	26
pathogenic viruses	26
neutralization test	26
unexposed individuals	26
differences among	26
two sets	26
molecular graphics	26
membrane glycoprotein	26
clinical symptoms	26
high coverage	26
interferon production	26
novel therapeutic	26
limb muscles	26
update rule	26
anp low	26
three qrt	26
protease activity	26
may result	26
current status	26
dna conjugates	26
overlapping genes	26
glucose tolerance	26
family cluster	26
envelope glycoprotein	26
therapeutic strategy	26
severe symptoms	26
antibodies elicited	26
take place	26
stem ii	26
subunit vaccines	26
meta path	26
huh cells	26
human fetal	26
igg titers	26
recurrent neural	26
coronavirus nonstructural	26
pcr testing	26
viral population	26
exploratory research	26
across participants	26
treat covid	26
mesh ewald	26
confocal microscopy	26
power spectrum	26
streptococcus pyogenes	26
barr virus	26
prism software	26
pangolin cov	26
potential target	26
human primate	26
learning approaches	26
unfolded protein	26
recombinant proteins	26
murine coronavirus	26
correlation analysis	26
using rna	26
molecular evolution	26
blood cell	26
hub proteins	26
trim proteins	26
using standard	26
accession numbers	26
plasmacytoid dendritic	26
comprehensive analysis	26
ace proteins	26
computed using	26
inner limbus	26
homologous recombination	26
radiology reports	26
speech perception	26
cellular membranes	26
transcriptional response	26
immunized mice	26
intrinsically disordered	26
mental health	26
encephalitis virus	26
steady state	26
high similarity	26
experimental conditions	26
also demonstrated	26
assortative mating	26
pitch discrimination	26
extracted using	26
base pair	26
end reads	26
nonhuman primate	26
major role	26
artificial intelligence	26
spike mutation	26
mortality rates	26
based sequence	26
rna sequence	26
two viruses	25
physiological ph	25
vaccinia virus	25
interleaved harmonic	25
predictive performance	25
igg ab	25
missense mutations	25
showed similar	25
nonhuman primates	25
ongoing pandemic	25
cellular receptor	25
lateral ankle	25
virus binding	25
myeloid cells	25
pyrimidine biosynthesis	25
recent years	25
intestinal organoids	25
significant reduction	25
marginated neutrophils	25
increasing number	25
plate reader	25
ace receptors	25
host interactome	25
experimental results	25
drug concentrations	25
homo sapiens	25
conserved regions	25
initial model	25
interferon responses	25
effective vaccine	25
study sars	25
based peptide	25
potent neutralization	25
studies showed	25
main text	25
mass spectrometer	25
study design	25
silico analysis	25
transmembrane serine	25
disease risk	25
confidence intervals	25
term memory	25
authentic sars	25
human immune	25
infectious dose	25
lamp assay	25
bat coronaviruses	25
functional assessment	25
visual inspection	25
provide important	25
cholesterol transport	25
virus strain	25
different levels	25
times higher	25
open conformation	25
plasmid dna	25
airway cells	25
middle eastern	25
receptor signaling	25
analysed using	25
data categories	25
quantitative pcr	25
distantly related	25
signal intensity	25
wavelet based	25
low expression	25
serum igg	25
identified two	25
cellular processes	25
understanding sars	25
software version	25
time step	25
infect humans	25
associated protein	25
quantitative analysis	25
physicochemical properties	25
respiratory epithelium	25
mutational signatures	25
also present	25
chemical mapping	25
limbal epithelial	25
clonal genotype	25
effectively inhibit	25
clinically relevant	25
site residues	25
data generated	25
binding modes	25
infectious sars	25
indicated time	25
spike peptide	25
electron acceptor	25
institutional review	25
aa sequences	25
cell transcriptome	25
sars plpro	25
indicating person	25
cov infections	25
gc content	25
statistical power	25
human sera	25
also significantly	25
tidal volume	25
cell number	25
assays using	25
created using	25
coronavirus orf	25
viral spread	25
illumina sequencing	25
cell division	25
following infection	25
extremely high	25
fold serial	25
cov genomes	25
human adenovirus	25
inhibits sars	25
rapid spread	25
autism spectrum	25
intermediate host	25
antiviral immunity	25
clinical severity	25
pixel size	25
treatment group	25
sequence alignments	25
rna structures	25
cells showed	25
high number	25
investigated whether	25
envelope proteins	25
beta cell	25
web application	25
pcr using	25
unique molecular	25
hydrogen bonding	25
coronavirus indicating	25
two additional	24
methods section	24
different populations	24
well established	24
also suggests	24
marker gene	24
cell function	24
di erent	24
key residues	24
clinically approved	24
water bath	24
em data	24
unless otherwise	24
disease transmission	24
adult pancreas	24
dna rna	24
fluorescent signal	24
nm spint	24
genome composition	24
high binding	24
existing immunity	24
healthy control	24
multiple cell	24
rbd region	24
rna samples	24
genetic analysis	24
decision tree	24
based detection	24
south america	24
acid binding	24
time spent	24
data showed	24
sequencing errors	24
natural products	24
across species	24
one rbd	24
might also	24
coronavirus pandemic	24
among others	24
novel severe	24
cell adhesion	24
per year	24
detailed analysis	24
mutant frequency	24
rationally designed	24
kidney disease	24
also confirmed	24
dna damage	24
cell interactions	24
horseshoe bats	24
major cell	24
differentially regulated	24
clustal omega	24
virological assessment	24
virus data	24
analysis pipeline	24
recent reports	24
tissues using	24
von willebrand	24
homology modelling	24
dna binding	24
nested pcr	24
emergency use	24
specific viral	24
coronavirus nl	24
cell sorting	24
homeostatic mechanisms	24
also suggest	24
evolutionary analysis	24
also provide	24
single stranded	24
acute kidney	24
molecular interactions	24
respiratory illness	24
identifying sars	24
clinical use	24
models using	24
one another	24
treatment groups	24
coronavirus genomes	24
green fluorescent	24
vaccine targets	24
phosphate buffered	24
candidate genes	24
time period	24
complex tones	24
results presented	24
dnase i	24
kindly provided	24
surface proteins	24
infectious agents	24
ml penicillin	24
recent advances	24
tattoo ink	24
viral nucleic	24
freely available	24
control wells	24
human plasma	24
receptor sequences	24
experiments using	24
free fatty	24
tracking changes	24
transcriptional changes	24
cells may	24
protein binds	24
respiratory symptoms	24
quadruplex structures	24
feature selection	24
used two	24
disease pathogenesis	24
motor evoked	24
significant correlation	24
solubility prediction	24
analysis software	24
viral control	24
industrial development	24
equilibrium md	24
recent report	24
codon optimization	24
aligned reads	24
background noise	24
harmonic sounds	24
i hla	24
performed according	24
cd cells	24
fetal brain	24
hidden markov	24
chest ct	24
dotted line	24
recombination event	23
airway epcs	23
protein atlas	23
massively parallel	23
experimental studies	23
ms analysis	23
high dose	23
two decades	23
showed significant	23
binding activity	23
genomic surveillance	23
mutational processes	23
reference database	23
harmonic tones	23
healthy human	23
immune cross	23
pro sars	23
validation set	23
coding genes	23
rna interactome	23
observations suggest	23
confirmed covid	23
results suggested	23
cpg content	23
mediated cell	23
stably transfected	23
protein domains	23
entry mechanisms	23
expression values	23
target gene	23
using one	23
results indicated	23
hace transgenic	23
different methods	23
trimeric sars	23
affinity chromatography	23
coronavirus oc	23
binding antibodies	23
natural killer	23
specific primers	23
zikv ns	23
limiting membrane	23
macromolecular structure	23
allow us	23
slippery sequence	23
nasal swabs	23
flow cytometric	23
feeder cells	23
ethics committee	23
elevated levels	23
pcr master	23
adult inpatients	23
idseq nt	23
study showed	23
also shows	23
ug ml	23
potential targets	23
see section	23
lung damage	23
within minutes	23
reference set	23
bars indicate	23
coronavirus main	23
viral copy	23
emerging coronavirus	23
old world	23
also evaluated	23
severe sars	23
antibody repertoire	23
snv calling	23
blood pressure	23
ribosome footprints	23
deleterious mutations	23
recognition receptors	23
drug delivery	23
humoral immunity	23
open state	23
random walk	23
simulation time	23
interaction energy	23
jak stat	23
time reverse	23
one possible	23
forming units	23
cse suppression	23
il ra	23
dmem supplemented	23
community detection	23
syrian hamster	23
small intestinal	23
proteolytic processing	23
three days	23
detecting sars	23
late md	23
early phase	23
binding kinetics	23
balance mechanisms	23
prediction using	23
i ifns	23
virus stock	23
may indicate	23
haddock score	23
dilution series	23
variant frequency	23
mutational hotspots	23
nhbe cells	23
hydrophobic residues	23
cell tropism	23
conjugated anti	23
single dose	23
neutrophil extracellular	23
chikungunya virus	23
will provide	23
coronavirus spikes	23
inharmonic conditions	23
vero cell	23
ncov infection	23
therapeutic efficacy	23
neutralizing titers	23
pulmonary edema	23
per reaction	23
antiviral therapies	23
molecular diagnostic	23
interacting residues	23
rapidly spread	23
sequenced using	23
receptor expression	23
elution buffer	23
cov susceptibility	23
tcr sequences	23
analyses revealed	23
carbon dioxide	23
fold lower	23
high confidence	23
much larger	23
nearly identical	23
based assays	23
stimulation intensity	23
transcriptional regulator	23
cell biology	23
predicted epitopes	23
data obtained	23
interface residues	23
random forest	23
significance threshold	23
replication machinery	23