quadgram

This is a table of type quadgram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

quadgram	frequency
severe acute respiratory syndrome	1027
acute respiratory syndrome coronavirus	741
of severe acute respiratory	250
in the presence of	224
as well as the	211
middle east respiratory syndrome	207
the severe acute respiratory	191
in the context of	191
in the absence of	189
in the case of	180
on the other hand	170
east respiratory syndrome coronavirus	146
can be used to	145
for the treatment of	142
of the spike protein	141
the total number of	121
structure of the sars	121
has been shown to	119
with a new coronavirus	115
of probable bat origin	114
new coronavirus of probable	114
pneumonia outbreak associated with	114
coronavirus of probable bat	114
a pneumonia outbreak associated	114
acute respiratory distress syndrome	114
outbreak associated with a	114
associated with a new	114
a new coronavirus of	114
as shown in figure	113
em structure of the	110
depends on ace and	108
on ace and tmprss	108
entry depends on ace	107
cell entry depends on	107
and tmprss and is	106
ace and tmprss and	106
blocked by a clinically	105
is blocked by a	105
and is blocked by	105
tmprss and is blocked	104
we found that the	104
by a clinically proven	104
a clinically proven protease	103
a large number of	102
clinically proven protease inhibitor	101
with respect to the	101
of the s protein	97
antigenicity of the sars	95
in the prefusion conformation	93
and antigenicity of the	91
for each of the	90
human respiratory disease in	89
we were able to	89
of the novel coronavirus	88
it is possible that	87
associated with human respiratory	87
new coronavirus associated with	87
with human respiratory disease	87
a new coronavirus associated	87
coronavirus associated with human	87
the d g mutation	87
a novel coronavirus from	86
spike protein of sars	86
the spike protein of	86
as a result of	85
respiratory disease in china	84
in addition to the	84
for the development of	84
was added to the	83
spike in the prefusion	83
at the same time	83
ncov spike in the	82
the receptor binding domain	81
of the sars coronavirus	80
these results suggest that	80
on the surface of	79
a wide range of	78
the structure of the	78
it is important to	78
for the detection of	78
the authors declare no	76
as a function of	75
in the present study	75
in patients with covid	74
copyright holder for this	73
of a novel coronavirus	73
holder for this preprint	73
the copyright holder for	73
is one of the	73
of patients infected with	72
the rest of the	72
was found to be	71
cd t cells in	71
an important role in	71
to the ace receptor	70
is consistent with the	69
were found to be	68
with severe acute respiratory	68
from patients with pneumonia	67
at the time of	67
the end of the	66
respiratory syndrome coronavirus spike	66
with pneumonia in china	65
at the s s	65
patients with pneumonia in	65
as shown in fig	65
was performed using the	64
novel coronavirus from patients	64
the dorsal accessory calyx	64
is the author funder	64
structural basis for the	64
coronavirus from patients with	64
at the end of	63
used in this study	63
have been shown to	62
the treatment of covid	62
with the exception of	62
in vitro and in	61
cells were treated with	61
clinical features of patients	61
one of the most	61
the presence of a	60
been shown to be	60
a final concentration of	60
features of patients infected	60
was used as a	59
in the form of	59
would like to thank	59
these results indicate that	59
is shown in figure	58
authors declare no competing	58
can be found in	58
by severe acute respiratory	58
at room temperature for	57
with novel coronavirus in	57
patients infected with novel	57
as well as in	57
entry into host cells	57
cd and cd t	57
bound to the ace	57
on the basis of	57
infected with novel coronavirus	57
analysis was performed using	56
a bp kenyon cells	56
specific cd t cells	56
in the spike protein	55
of the severe acute	55
and the number of	55
the crystal structure of	55
epidemiology of novel coronavirus	54
in vero e cells	54
made available under a	54
vitro and in vivo	54
is made available under	54
domain bound to the	54
characterisation and epidemiology of	53
syndrome coronavirus spike protein	53
novel coronavirus in wuhan	53
and epidemiology of novel	53
genomic characterisation and epidemiology	53
in the treatment of	53
in the number of	52
the presence of the	52
memory cd t cells	52
the s protein of	52
for the first time	52
the world health organization	52
orf a and orf	52
for virus origins and	51
for the recognition of	51
virus origins and receptor	51
at a concentration of	51
under a the copyright	51
the length of the	51
origins and receptor binding	51
declare no competing interests	51
available under a the	51
a the copyright holder	51
implications for virus origins	51
the context of the	50
in agreement with the	50
binding domain bound to	50
of hospitalized patients with	50
in the lungs of	50
the fact that the	49
the limit of detection	49
it is likely that	49
the surface of the	49
was added to each	49
in patients with severe	48
cells were infected with	48
for the analysis of	48
basis for the recognition	48
n s p g	48
was supported by the	47
it has been shown	47
the beginning of the	47
as well as a	47
at the level of	47
are shown in figure	47
in the united states	47
added to each well	47
the size of the	47
gene set enrichment analysis	46
play a role in	46
s s cleavage site	46
this work was supported	46
of middle east respiratory	45
the protein data bank	44
in contrast to the	44
the analysis of the	44
these data suggest that	44
sharing all influenza data	44
shown in figure a	44
of ace and tmprss	44
hospitalized patients with covid	43
we would like to	43
the results of the	43
t t a t	43
s and s subunits	43
t g t t	43
n s p c	43
global initiative on sharing	43
the binding of the	43
work was supported by	43
this is consistent with	43
a functional receptor for	43
the s s cleavage	43
our results suggest that	42
crystal structure of the	42
for the presence of	42
were added to the	42
proximal origin of sars	42
human immunodeficiency virus type	42
results suggest that the	42
at the beginning of	42
the novel coronavirus from	42
in the pathogenesis of	42
of the viral genome	42
studies have shown that	42
the proximal origin of	42
in the range of	42
on sharing all influenza	41
the causative agent of	41
t c g t	41
is the number of	41
peripheral blood mononuclear cells	41
the recognition of sars	41
initiative on sharing all	41
in the development of	41
is a functional receptor	41
on vero e cells	41
presence or absence of	40
the use of the	40
it is possible to	40
functional receptor for the	40
there is an urgent	40
the presence or absence	39
as compared to the	39
the authors declare that	39
figure a and b	39
play an important role	39
the majority of the	39
the role of the	39
by the addition of	39
we did not observe	39
minutes at room temperature	39
detection of novel coronavirus	39
the viral spike protein	39
of the number of	39
the performance of the	39
it should be noted	39
has been reported to	39
of receptor recognition by	38
cell types in the	38
should be noted that	38
the expression of the	38
was carried out using	38
the innate immune response	38
basis of receptor recognition	38
was not certified by	38
of cd t cells	38
in the regulation of	38
it is made available	38
receptor recognition by sars	38
was performed using a	38
structural basis of receptor	38
certified by peer review	38
human airway epithelial cells	38
is an urgent need	38
standard error of the	38
the stability of the	38
s protein of sars	38
expression of ace and	38
not certified by peer	38
structural and functional basis	37
cd t cells were	37
and functional basis of	37
to determine whether the	37
to better understand the	37
the s and s	37
t c t t	37
in terms of the	37
disease control and prevention	37
were obtained from the	37
functional basis of sars	37
these data indicate that	37
to the development of	37
can be used for	36
error of the mean	36
t t t t	36
we observed that the	36
the course of the	36
systematic review and meta	36
min at room temperature	36
respiratory syndrome coronavirus infection	36
has been shown that	36
is based on the	36
the ability of the	35
a broad range of	35
the middle east respiratory	35
the impact of the	35
which is consistent with	35
our results indicate that	35
to be involved in	35
no conflict of interest	35
by using human ace	35
in this study were	35
authors would like to	35
has the potential to	35
by the novel coronavirus	35
in line with the	35
a systematic review and	35
an analysis based on	35
the detection of sars	35
the expression of ace	35
to be able to	35
national institutes of health	35
the evolution of the	35
hour at room temperature	35
entry by using human	35
were infected with sars	35
to the presence of	35
which was not peer	35
patients with coronavirus disease	35
n s p a	35
for minutes at room	35
the distribution of the	35
of the virus in	34
d g mutation in	34
for min at room	34
with acute respiratory distress	34
it was found that	34
the effect of the	34
novel coronavirus from wuhan	34
as described in the	34
analysis based on decade	34
in accordance with the	34
structural studies of sars	34
the s protein is	34
similar to that of	34
spike glycoprotein of sars	34
t t g t	34
at the university of	34
as well as to	34
for disease control and	34
the sars coronavirus spike	34
caused by severe acute	33
was observed in the	33
binding domain complexed with	33
long structural studies of	33
of coronavirus spike proteins	33
to the number of	33
in this study we	33
this suggests that the	33
a better understanding of	33
of the s subunit	33
s s c t	33
protein interaction map reveals	33
receptor for the sars	32
n s p t	32
on the origin and	32
is known to be	32
in the current study	32
for the sars coronavirus	32
into the host cell	32
s c t s	32
by the presence of	32
with the novel coronavirus	32
are listed in table	32
host response to sars	31
enzyme is a functional	31
converting enzyme is a	31
crystal structure of sars	31
we show that the	31
a wide variety of	31
the interaction between the	31
over the course of	31
is likely to be	31
test was used to	31
the authors would like	31
that the majority of	31
for a total of	31
the a bp kenyon	31
were used for the	31
by the fact that	31
antibody responses to sars	31
the development of a	31
to a final concentration	31
the emergence of sars	31
type i and type	31
in human airway epithelial	31
are likely to be	30
a significant increase in	30
to that of the	30
during the course of	30
the central nervous system	30
t cell responses to	30
by the severe acute	30
the nature of the	30
an increase in the	30
t cells in the	30
it has been reported	30
results indicate that the	30
analysis of the sars	30
can be explained by	29
as the number of	29
patients with severe acute	29
the species severe acute	29
species severe acute respiratory	29
of sars coronavirus spike	29
national center for biotechnology	29
data are presented as	29
identification of a novel	29
is supported by the	29
drives development of covid	29
of the innate immune	29
that can be used	29
of the virus and	29
the amino acid sequence	29
these findings suggest that	29
s a and s	29
had no effect on	29
performed as previously described	29
the large number of	29
expression of ace in	29
h at room temperature	29
be explained by the	29
the binding free energy	29
center for biotechnology information	29
in order to identify	29
of hepatitis c virus	29
we next sought to	29
characteristics of coronavirus disease	29
of the active site	28
the emergence of a	28
more likely to be	28
imbalanced host response to	28
structure of sars coronavirus	28
it is worth noting	28
domain complexed with receptor	28
as a positive control	28
plays an important role	28
is required for the	28
a t a t	28
and cd t cells	28
was used for the	28
by the world health	28
a small number of	28
c t t t	28
with fetal bovine serum	28
a retrospective cohort study	28
g t t a	28
as well as for	28
patients with severe covid	28
single cell rna sequencing	28
this is the first	28
are shown in fig	28
the innate immune system	28
of vero e cells	28
of coronavirus disease in	28
the rbd of sars	28
ncov and naming it	28
be used as a	28
to the host cell	28
clinical characteristics of coronavirus	28
associated with acute respiratory	28
a key role in	28
data with implanted signals	28
spread of the virus	28
a web server for	28
was used as the	28
vero e cells and	27
it is necessary to	27
may be due to	27
an urgent need for	27
as can be seen	27
a role in the	27
of s and s	27
is responsible for the	27
the use of a	27
the national center for	27
the start of the	27
the rbd of the	27
a member of the	27
the vast majority of	27
of the amino acid	27
is important to note	27
has been reported that	27
p p p p	27
were carried out using	27
s d and s	27
receptor recognition by the	27
for the study of	27
and naming it sars	27
targets for drug repurposing	27
the center of the	27
isolation and characterization of	27
that they have no	27
coronavirus disease in china	27
important to note that	27
in order to determine	27
an urgent need to	27
recognition by the novel	27
higher than that of	27
of influenza a virus	27
respiratory syndrome coronavirus in	27
the quality of the	27
for hour at room	27
the case of the	27
the antiviral activity of	27
on the number of	26
exploratory research and analysis	26
the s subunit of	26
in the s protein	26
a high degree of	26
coronavirus spike protein by	26
are more likely to	26
are consistent with the	26
system for exploratory research	26
the results showed that	26
of cell entry and	26
identification and characterization of	26
in any of the	26
have the potential to	26
reveals targets for drug	26
a t t t	26
for exploratory research and	26
map reveals targets for	26
declare that they have	26
as part of the	26
the immune response to	26
our data suggest that	26
the spread of the	26
that d g increases	26
interaction map reveals targets	26
were included in the	26
analyses were performed using	26
the average number of	26
and evolution of coronavirus	26
can be applied to	26
g t t g	26
visualization system for exploratory	26
is similar to the	26
in comparison to the	26
is worth noting that	26
vero e cells were	26
a function of the	25
a critical role in	25
a visualization system for	25
origin and evolution of	25
entry and receptor usage	25
a study of a	25
pneumonia associated with the	25
is possible that the	25
of a family cluster	25
the novel coronavirus indicating	25
evolution of coronavirus spike	25
from vision to reality	25
the difference between the	25
cell entry and receptor	25
our understanding of the	25
infectivity of the covid	25
it is known that	25
associated with the novel	25
s g r n	25
risk factors for mortality	25
is shown in fig	25
washed three times with	25
were aligned to the	25
we find that the	25
been reported to be	25
familial cluster of pneumonia	25
figure c and d	25
structures of the sars	25
cluster of pneumonia associated	25
could be used to	25
as well as other	25
the presence of sars	25
authors declare that they	25
a and orf b	25
of pneumonia associated with	25
functional assessment of cell	25
that there is a	25
d g increases infectivity	25
the viral life cycle	25
novel coronavirus indicating person	25
study of a family	25
in a variety of	25
and receptor usage for	25
a familial cluster of	25
centers for disease control	25
is in line with	25
the dynamics of the	25
neutralizing antibodies against sars	25
incubated for min at	25
g r n a	25
the expression level of	25
t t t a	25
d and s d	25
mediated by the viral	25
evidence that d g	25
but not in the	25
assessment of cell entry	25
in response to the	25
the importance of the	25
an r package for	25
for severe acute respiratory	24
other lineage b betacoronaviruses	24
at a density of	24
t a t c	24
data suggest that the	24
studies of sars coronavirus	24
of each of the	24
in at least one	24
virological assessment of hospitalized	24
assessment of hospitalized patients	24
in the presence or	24
increases infectivity of the	24
of angiotensin converting enzyme	24
composition and divergence of	24
and risk factors for	24
the binding of sars	24
be found in the	24
the modified cdc sars	24
the area under the	24
as a negative control	24
incubated at room temperature	24
it is also possible	24
as a consequence of	24
have been reported to	24
in the respiratory tract	24
g t c g	24
it is difficult to	24
in a mouse model	24
there was a significant	24
the effects of the	24
tracking changes in sars	24
g increases infectivity of	24
was used to identify	24
under the control of	24
receptor usage for sars	24
and other lineage b	24
dependent rna polymerase from	24
isolation of a novel	24
a systematic review of	24
to a lesser extent	24
on virus entry and	23
is supported by a	23
novel severe acute respiratory	23
of spike glycoprotein of	23
evolution of pathogenic coronaviruses	23
were added to each	23
there was no significant	23
entry into the host	23
the architecture of sars	23
atcf l ko mice	23
adult inpatients with covid	23
t t c t	23
man with pneumonia in	23
course and risk factors	23
were performed using the	23
and characterization of a	23
we also found that	23
was carried out in	23
novel coronavirus from a	23
and evolution of pathogenic	23
of human immunodeficiency virus	23
clinical course and risk	23
factors for mortality of	23
for the production of	23
of the human genome	23
with pneumonia in saudi	23
may contribute to the	23
in this study are	23
of adult inpatients with	23
has not yet been	23
and middle east respiratory	23
we have developed a	23
i and type iii	23
for their ability to	23
mortality of adult inpatients	23
more than of the	23
functional receptor for sars	23
of the virus to	23
in health and disease	23
no conflicts of interest	23
the novel coronavirus sars	23
related coronaviruses in malayan	23
could be due to	23
is defined as the	23
from a man with	23
the host cell membrane	23
coronavirus from a man	23
a and s a	23
was calculated using the	23
entry and its immune	23
a man with pneumonia	23
of patients with covid	23
to the lack of	23
for mortality of adult	23
of type i interferon	23
sars coronavirus spike receptor	23
patients with novel coronavirus	23
coronaviruses in malayan pangolins	23
and its immune cross	23
in the s subunit	23
of the d g	23
associated with the covid	23
virus entry and its	23
c g t t	23
characterization of spike glycoprotein	22
we did not find	22
calculated based on the	22
structure and function of	22
we set out to	22
the early stages of	22
glycoprotein in complex with	22
is closely related to	22
was shown to be	22
and clinical characteristics of	22
can be used as	22
ray crystal structure of	22
a s g r	22
a human monoclonal antibody	22
this version posted june	22
shown in figure b	22
better understanding of the	22
a major role in	22
to each of the	22
human pluripotent stem cells	22
pangolin origin of sars	22
of t cell responses	22
which was not certified	22
the composition of the	22
a first step in	22
in cd t cells	22
that most of the	22
important role in the	22
were downloaded from the	22
the onset of the	22
the mhc i hla	22
these results demonstrate that	22
with the addition of	22
can be seen in	22
the binding affinity of	22
were detected in the	22
when compared to the	22
amino acid sequence of	22
were excluded from the	22
were calculated using the	22
type i interferon signaling	22
is mediated by the	22
is in agreement with	22
to the fact that	22
are known to be	22
was performed with the	22
g mutation in the	22
for the identification of	22
r n a s	22
pneumonia in saudi arabia	22
a flow rate of	22
to be associated with	21
as one of the	21
was detected in the	21
a c a a	21
listed in table s	21
results showed that the	21
in the active site	21
characteristics of cases of	21
sars coronavirus spike glycoprotein	21
in the process of	21
the origin and continuing	21
to test this hypothesis	21
this preprint this version	21
binding affinity to the	21
animal care and use	21
airway epithelial cells and	21
without the need for	21
way anova followed by	21
it has been suggested	21
the d structure of	21
x n s p	21
declare no conflict of	21
best of our knowledge	21
was obtained from the	21
the sequence of the	21
n a s g	21
the top of the	21
of genes involved in	21
the average of the	21
at least in part	21
origin and continuing evolution	21
for h at room	21
is essential for the	21
these data demonstrate that	21
a novel coronavirus associated	21
spike glycoprotein in complex	21
domain of the spike	21
of type i ifn	21
the functional receptor for	21
highly expressed in nasal	21
were identified in the	21
uniform manifold approximation and	21
the best of our	21
cells were washed with	21
here we show that	21
the magnitude of the	21
are shown in table	21
followed by cycles of	21
is located in the	21
was used to determine	21
manifold approximation and projection	21
supplemented with fetal bovine	21
novel coronavirus associated with	21
we did not detect	21
the pathogenesis of covid	21
has been suggested that	21
a a a a	21
the number of sequences	21
epitope in the receptor	21
the identity of the	21
was approved by the	21
for this preprint this	21
a highly conserved cryptic	21
were washed three times	21
our results show that	21
patients infected with sars	21
and continuing evolution of	21
cryptic epitope in the	21
in one of the	21
new insights into the	21
it is not clear	21
that the number of	21
little is known about	21
the coronavirus spike protein	21
this study are available	21
first step in understanding	21
conserved cryptic epitope in	21
the s s site	21
carried out using the	21
than that of the	21
effect on vero e	21
due to the presence	21
the evolution of sars	21
the absence of the	21
the virus in the	21
highly conserved cryptic epitope	21
continuing evolution of sars	21
the spike protein and	21
preprint this version posted	21
at a moi of	21
a limited number of	21
transmission dynamics in wuhan	21
it is interesting to	21
the severity of the	21
was performed as described	21
at an moi of	20
in the same way	20
statistical analysis was performed	20
in response to sars	20
cells were fixed with	20
c t s g	20
a result of the	20
have no competing interests	20
in the human population	20
recently emerged novel coronavirus	20
the recently emerged novel	20
at least of the	20
hours at room temperature	20
at o c for	20
in most of the	20
in each of the	20
the level of the	20
the origin of sars	20
remdesivir and chloroquine effectively	20
effectively inhibit the recently	20
at a flow rate	20
and to a lesser	20
s g c t	20
a c t s	20
and the presence of	20
l n s p	20
the extent to which	20
rna was isolated from	20
the activity of the	20
due to the lack	20
cells were incubated with	20
tissue distribution of ace	20
to severe acute respiratory	20
mechanism of action of	20
gla and adj gla	20
t a t a	20
can be divided into	20
for the purpose of	20
and chloroquine effectively inhibit	20
the position of the	20
at the protein level	20
in order to assess	20
we are grateful to	20
the results of this	20
it is noteworthy that	20
amino acid sequences of	20
were generated using the	20
at a rate of	20
have been used to	20
in the lung and	20
was used to calculate	20
with the amino acids	20
referred to as the	20
chloroquine effectively inhibit the	20
to the best of	20
of the immune system	20
binding domains of sars	20
in the viral genome	20
the s s junction	20
the number of reads	20
distribution of ace protein	20
high expression of ace	20
all over the world	20
inhibit the recently emerged	20
the human ace receptor	20
probable pangolin origin of	20
were washed twice with	20
a a t a	20
it remains to be	20
was not detected in	20
is due to the	20
the host immune response	20
were not able to	20
total rna was isolated	19
receptor for sars coronavirus	19
cell responses to sars	19
basis for design of	19
clinical characteristics of cases	19
the context of covid	19
at room temperature and	19
we have shown that	19
c t s d	19
characteristics of hospitalized patients	19
innovative contribution to global	19
of amino acid residues	19
based dashboard to track	19
of the three qrt	19
a small animal model	19
a a c a	19
than that of sars	19
were observed in the	19
step in understanding sars	19
dashboard to track covid	19
t a t t	19
in the s domain	19
the human adult pancreas	19
l c t s	19
we hypothesized that the	19
provides a basis for	19
used to calculate the	19
one of the major	19
these results show that	19
no significant differences in	19
is known about the	19
on the expression of	19
of novel coronavirus pneumonia	19
the control of the	19
h n influenza virus	19
was applied to the	19
authors declare no conflict	19
immune responses to sars	19
was then added to	19
secondary structure of the	19
spike protein is a	19
likely due to the	19
in the human genome	19
the duration of the	19
in patients with coronavirus	19
a high level of	19
like to thank the	19
probable bat origin a	19
and divergence of the	19
the posterior lateral protocerebrum	19
genome composition and divergence	19
see materials and methods	19
of the immune response	19
we took advantage of	19
for the prediction of	19
as shown in table	19
in understanding sars pathogenesis	19
not included in the	19
tracking of pathogen evolution	19
of ace expression in	19
divergence of the novel	19
to bind to the	19
analysis was performed on	19
clinical characteristics of hospitalized	19
s c c t	19
time tracking of pathogen	19
in the majority of	19
of this study was	19
pave the way for	19
the national institutes of	19
analysis revealed that the	19
c g t c	19
to that of sars	19
the active site of	19
the humoral immune response	19
the frequency of the	19
isolated from a patient	19
influenza a virus infection	19
in an effort to	19
results are consistent with	19
the complexity of the	19
were removed from the	19
s s s s	19
contribution to global health	19
the study of the	19
entry mediated by the	18
the presence of ace	18
was calculated for each	18
in the receptor binding	18
with the help of	18
in complex with the	18
t s o c	18
mean and standard deviation	18
b c t s	18
been found to be	18
and incubated for min	18
c t s o	18
s a c t	18
can also be used	18
t s e c	18
c t s f	18
at room temperature with	18
bonds with the amino	18
at least one of	18
causative agent of covid	18
t s c c	18
be due to the	18
the formation of the	18
and structures of a	18
of the viral spike	18
a c t a	18
due to the low	18
to the primary site	18
the distance between the	18
coronavirus associated with severe	18
care and use committee	18
room temperature for minutes	18
characterization of a novel	18
structures of a rationally	18
one of the main	18
g for min at	18
from the md simulations	18
t s g c	18
the number of infected	18
a large proportion of	18
s h c t	18
of mouse hepatitis virus	18
t a a t	18
was performed on the	18
c t s h	18
with and without a	18
t cell responses in	18
c t s s	18
each of the three	18
on the first syllable	18
a mouse model of	18
h c t s	18
the lateral ankle mechanism	18
s e c t	18
t s f c	18
the presence of an	18
in nasal epithelial cells	18
the expression levels of	18
in the course of	18
rna was extracted from	18
t s k c	18
of a rationally designed	18
s b c t	18
f c t s	18
c t s w	18
t s v c	18
entry mechanisms of sars	18
c t s k	18
s v c t	18
c t s e	18
s l c t	18
s f c t	18
t s w c	18
our results showed that	18
was transferred to a	18
to further investigate the	18
e c t s	18
are available from the	18
we were unable to	18
for binding to the	18
by the end of	18
were used in the	18
plays a role in	18
rationally designed prefusion mers	18
and functional characterization of	18
c t s c	18
c c t s	18
t cells in lungs	18
other members of the	18
g c t s	18
are highly expressed in	18
s o c t	18
d c t s	18
an essential role in	18
a t a a	18
in the expression of	18
could be used as	18
world data with implanted	18
t s d c	18
associated with severe acute	18
of tcf l in	18
at g for min	18
k c t s	18
immunogenicity and structures of	18
v c t s	18
binding domain of the	18
as a loading control	18
t s a c	18
for treatment of covid	18
the context of a	18
c t s l	18
a potential target for	18
a modified version of	18
cells were transfected with	18
in relation to the	18
o c t s	18
it has also been	18
each of the two	18
tissue culture infectious dose	18
t s b c	18
has been implicated in	18
the intensity of the	18
t s h c	18
t s l c	18
in this work we	18
v n s p	18
of its spike protein	18
was used to generate	18
s d c t	18
in line with this	18
c t s a	18
similar to those of	18
mice were treated with	18
results show that the	18
the rbd and the	18
c t s v	18
shed light on the	18
grid search over hyperparameters	18
a novel coronavirus in	18
s k c t	18
of differentially expressed genes	18
hospitalized patients with novel	18
the upper respiratory tract	18
and function of the	18
in the main text	18
epidemiological and clinical characteristics	18
and the supernatant was	18
and incubated for h	18
with an ic of	18
t s s c	18
a rationally designed prefusion	18
is part of the	18
is associated with a	17
one of the two	17
they have no competing	17
a a t t	17
safety and immunogenicity of	17
orf b gene assay	17
of the receptor binding	17
using a combination of	17
at x g for	17
in the up conformation	17
were analyzed using the	17
porcine epidemic diarrhea virus	17
it is clear that	17
an analysis of the	17
by the viral spike	17
in the center of	17
pcr was performed using	17
s w c t	17
and the development of	17
in hek t cells	17
mafft multiple sequence alignment	17
be involved in the	17
the molecular mechanism of	17
human bronchial epithelial cells	17
was calculated based on	17
of the spike glycoprotein	17
cells in the lungs	17
from a patient with	17
institutional animal care and	17
of the viral envelope	17
at room temperature in	17
used to generate the	17
shown in figure c	17
approved by the institutional	17
we are able to	17
the active site and	17
vero e cells exposed	17
harmonic and inharmonic conditions	17
cd t cell responses	17
of the ace receptor	17
cells were incubated for	17
in the low condition	17
is also possible that	17
a change in the	17
to those of the	17
targets of t cell	17
in severe acute respiratory	17
was defined as the	17
coronavirus in humans with	17
in lung epithelial cells	17
it is expected that	17
the s proteins of	17
cell entry mechanisms of	17
receptor binding domain of	17
a multiple sequence alignment	17
disease and unexposed individuals	17
e cells exposed to	17
are given in table	17
of protein structures and	17
as a target for	17
multiple sequence alignment software	17
cell atlas of the	17
a pivotal role in	17
the mechanism of action	17
coronavirus in patients with	17
was done using the	17
was also observed in	17
each of the four	17
the development of new	17
the immune epitope database	17
pellet was resuspended in	17
ace and tmprss are	17
food and drug administration	17
incubated for hours at	17
to interact with the	17
used to determine the	17
cases of novel coronavirus	17
with at least one	17
a t c t	17
c bl j mice	17
respiratory syndrome coronavirus orf	17
a significant number of	17
em structures of mers	17
closely related to the	17
the formation of a	17
that are known to	17
recent insights into emerging	17
is involved in the	17
the spike glycoprotein of	17
t cell immunity in	17
c t a t	17
in humans with covid	17
antiviral activity against sars	17
to the dorsal accessory	17
has been reported for	17
centrifuged at g for	17
compared to the other	17
for hours at room	17
that some of the	17
have been developed to	17
of modern hopfield networks	17
insights into emerging coronaviruses	17
improvements in performance and	17
is more likely to	17
hydrogen bonds with the	17
human sars and bat	17
which this version posted	17
was added to a	17
the type i interferon	17
were approved by the	16
spike glycoproteins reveal the	16
pathological findings of covid	16
other domesticated animals to	16
this study was to	16
is highly expressed in	16
in direct contact with	16
beat gesture on the	16
in performance and usability	16
be noted that the	16
in a previous study	16
used in the study	16
a subset of the	16
of critically ill patients	16
of the n protein	16
significant differences in the	16
sequence alignment software version	16
were considered to be	16
c t s b	16
were mapped to the	16
the upper and lower	16
reveals the emergence of	16
is thought to be	16
the development of vaccines	16
the sequence alignment map	16
homology modelling of protein	16
have been reported in	16
to the surface of	16
with innate immune genes	16
cells were fixed and	16
of a coronavirus spike	16
electron microscopy structures of	16
the free energy of	16
nasal epithelial cells together	16
of the novel human	16
cells together with innate	16
for the synthesis of	16
viral entry into the	16
cells were incubated at	16
together with innate immune	16
when the number of	16
with the presence of	16
as an internal control	16
was not due to	16
factors are highly expressed	16
of type i interferons	16
that the presence of	16
epithelial cells together with	16
of genes associated with	16
and bat cov are	16
reveal the dynamic receptor	16
can serve as a	16
the highest binding affinity	16
for the inhibition of	16
the furin cleavage site	16
the early phase of	16
d structure of the	16
modelling of protein structures	16
in section a we	16
the differentially expressed genes	16
the cells were incubated	16
coronavirus isolated from a	16
caused by the severe	16
human pluripotent stem cell	16
on the cell surface	16
it was reported that	16
may play a role	16
receptor ace is an	16
for min at rt	16
committee on taxonomy of	16
conformational changes induced by	16
license was not certified	16
the secondary structure of	16
h n and h	16
alignment map format and	16
dynamic receptor binding domains	16
as indicated by the	16
between s and s	16
of a subset of	16
did not show any	16
of ace in the	16
mutation in the sars	16
well as in the	16
coronavirus spike protein is	16
amino acid sequence identity	16
are present in the	16
in the nasal cavity	16
expressed in nasal epithelial	16
this is in line	16
the same set of	16
the n k mutation	16
the integrity of the	16
n and h n	16
glycoproteins reveal the dynamic	16
license is made available	16
molecular evolutionary genetics analysis	16
signal to noise ratio	16
the standard genetic code	16
of cases of novel	16
the degree to which	16
even in the absence	16
are presented as mean	16
ace is an interferon	16
the tailed amplicon v	16
the inhibition of the	16
cov spike glycoproteins reveal	16
a fraction of the	16
a crucial role in	16
and other domesticated animals	16
the sensitivity of the	16
the donut pcr platform	16
sequence alignment map format	16
novel coronavirus pneumonia in	16
may be related to	16
for the spike protein	16
protein structures and complexes	16
the prefusion conformation structure	16
of the interaction between	16
s proteins of sars	16
map format and samtools	16
was removed and the	16
an overview of the	16
were retrieved from the	16
international license is made	16
could be found in	16
host cell receptor ace	16
a measure of the	16
the s s boundary	16
w c t s	16
s p a a	16
activation of the sars	16
c a a t	16
closely related to sars	16
to determine if the	16
protein of severe acute	16
international committee on taxonomy	16
figure b and c	16
of instances per bag	16
to the reference genome	16
a multiplicity of infection	16
entry factors are highly	16
caused by a novel	16
the dynamic receptor binding	16
in more than one	16
a single dose of	16
the genomes of sars	16
statistical analyses were performed	16
international license was not	16
is a member of	15
to the human genome	15
moderated estimation of fold	15
the impact of mutations	15
area under the curve	15
transmissible form of sars	15
spike protein by a	15
in vivo and in	15
cov spike glycoprotein reveal	15
we believe that the	15
with the severe acute	15
i n s p	15
a target for vaccine	15
that could not be	15
the origin of the	15
is likely due to	15
of coronavirus cell entry	15
studies are needed to	15
has been linked to	15
shown in figure s	15
cell rna sequencing data	15
are presented in table	15
on the host cell	15
of ace in human	15
more transmissible form of	15
determined by plaque assay	15
we focused on the	15
neutralizing antibodies elicited by	15
pipeline reveals the emergence	15
critically ill patients with	15
presence and absence of	15
the replication of sars	15
to the spike protein	15
t t a a	15
protein in complex with	15
the relationship between the	15
novel coronavirus in patients	15
spike mutation pipeline reveals	15
the core of the	15
is consistent with a	15
in close proximity to	15
frozen in liquid nitrogen	15
causative agent of the	15
for design of improved	15
the number of tests	15
of dot l in	15
cells in patients with	15
on the development of	15
prevention and treatment of	15
fusion of the viral	15
with its host cell	15
is a class i	15
the activation of the	15
there was no difference	15
african green monkey kidney	15
has been associated with	15
in specific cell subsets	15
in engineered human tissues	15
type i ifn signaling	15
evolution of the novel	15
the international committee on	15
did not observe any	15
may be associated with	15
we speculate that the	15
the findings of this	15
did not affect the	15
remdesivir for the treatment	15
the interactions between the	15
hundreds of thousands of	15
coronavirus cell entry mediated	15
the addition of the	15
in the evolution of	15
the maximum number of	15
a concentration of nm	15
to be used for	15
caused by the novel	15
these observations suggest that	15
was predicted to be	15
a language and environment	15
main protease provides a	15
plates were incubated for	15
sars coronavirus spike protein	15
all of which are	15
stimulated gene in human	15
hr at room temperature	15
the potential role of	15
s p c a	15
error bars represent the	15
mechanisms of coronavirus cell	15
for membrane fusion and	15
the middle of the	15
can be seen from	15
wild type and mutant	15
the absence of a	15
the rapid development of	15
protease provides a basis	15
as in the case	15
ace expression in human	15
storm syndromes and immunosuppression	15
cells were seeded in	15
samples were collected from	15
spike glycoprotein reveal a	15
was found to have	15
was carried out by	15
dalla man et al	15
o r f a	15
was performed according to	15
with the number of	15
used at a concentration	15
consider cytokine storm syndromes	15
environment for statistical computing	15
with the aim of	15
to account for the	15
to the identification of	15
to each well and	15
incubated for h at	15
in complex with its	15
limit of detection of	15
differential gene expression analysis	15
to an increase in	15
gene in human airway	15
these findings indicate that	15
and environment for statistical	15
was performed as previously	15
microscopy structures of the	15
the lower respiratory tract	15
engineered human tissues using	15
in the dorsal accessory	15
were performed using a	15
vaccine and therapeutic development	15
are involved in the	15
emergence of a more	15
in comparison with the	15
s p g t	15
the first case of	15
study was supported by	15
influenza a h n	15
of a more transmissible	15
specific memory cd t	15
evolution of the virus	15
c t s z	15
a potent inhibitor of	15
the genome of the	15
cell rna sequencing of	15
the significance of the	15
that the expression of	15
the specificity of the	15
the direction of the	15
respiratory syndrome coronavirus receptor	15
a basis for design	15
due to the high	15
and functional analysis of	15
standard deviation of the	15
rbd and the ace	15
reads were aligned to	15
the hepatitis c virus	15
the central polar cavity	15
cell entry mediated by	15
with the ace receptor	15
the possibility that the	15
mutation pipeline reveals the	15
samples from patients with	15
infections in engineered human	15
coronavirus open reading frame	15
on the second syllable	15
are predicted to be	15
a more transmissible form	15
the rbd in the	15
in the control of	15
these results suggested that	15
estimation of fold change	15
expression profiling of ace	15
and adj gla groups	15
is predicted to be	15
with the fact that	15
can be extended to	15
cytokine storm syndromes and	15
the early stage of	15
cells infected with sars	15
the high level of	15
coronavirus pneumonia in wuhan	15
it is well known	15
analysis was performed with	15
novel coronavirus from the	15
activation of rnase l	15
this indicates that the	15
by the total number	15
number of instances per	15
structural and functional characterization	15
was found that the	15
language and environment for	15
the absence of any	15
the molecular basis of	15
and cd t cell	15
as severe acute respiratory	14
in order to understand	14
in the same manner	14
cd t cells and	14
human intestinal epithelial cells	14
the interaction of the	14
grade soluble human ace	14
number of infected cells	14
coronavirus from the ongoing	14
before and after the	14
c t g t	14
may play an important	14
golden syrian hamster model	14
domesticated animals to sars	14
the presence and absence	14
were incubated with the	14
spike protein reduces s	14
a small fraction of	14
reduces s shedding and	14
a time step of	14
as well as an	14
the molecular biology of	14
rnase l ko cells	14
the basis of the	14
we have previously shown	14
data are shown as	14
for each cell type	14
model of the sars	14
search over hyperparameters with	14
and transmission of sars	14
cause of severe acute	14
change and dispersion for	14
of fold change and	14
the amino acid sequences	14
convergent antibody responses to	14
fold change and dispersion	14
despite the fact that	14
cell epitopes in the	14
the s domain of	14
specific cell subsets across	14
at the start of	14
the ongoing wuhan outbreak	14
and wrote the manuscript	14
of antiviral drug candidates	14
spike protein for risk	14
reactive t cells in	14
is caused by the	14
protein reduces s shedding	14
protein for risk of	14
for risk of human	14
glycoprotein reveal a prerequisite	14
we note that the	14
this study was supported	14
of the human lung	14
have been found to	14
its host cell receptor	14
for the formation of	14
upper and lower respiratory	14
wilcoxon rank sum test	14
to ensure that the	14
targets for immune responses	14
the strength of the	14
highest binding affinity to	14
the function of the	14
for the control of	14
the authors have no	14
amino acid residues in	14
is available at https	14
we sought to determine	14
the structure of sars	14
in line with previous	14
a central role in	14
changes induced by receptor	14
were more likely to	14
a and s b	14
infected pneumonia in wuhan	14
in terms of their	14
antibody response to sars	14
in the vicinity of	14
t g t c	14
has been used in	14
in addition to these	14
and modeling of its	14
g t g t	14
to be the most	14
early transmission dynamics in	14
potent neutralizing antibodies against	14
compared to the reference	14
the s protein to	14
outbreak and modeling of	14
over hyperparameters with reduction	14
in old at cells	14
is used as a	14
the centers for disease	14
modeling of its spike	14
it is unlikely that	14
and peripheral blood mononuclear	14
y n s p	14
with the host cell	14
hyperparameters with reduction to	14
human tissues using clinical	14
used as a reference	14
no significant differences were	14
did not find any	14
for immune responses to	14
reduce the number of	14
in our previous study	14
the supernatant was collected	14
the plates were incubated	14
ongoing wuhan outbreak and	14
of the s domain	14
for the use of	14
n and n ct	14
have been able to	14
epithelial cells and is	14
its spike protein for	14
the sequences of the	14
the aim of this	14
the novel severe acute	14
in the supplementary material	14
were found in the	14
ace and tmprss in	14
used in this work	14
and adj cpg groups	14
the number of cells	14
cells as well as	14
actin served as a	14
of genes and genomes	14
coronavirus spike protein for	14
state for receptor binding	14
functional characterization of the	14
for each of these	14
cells were washed twice	14
for the design of	14
were predicted to be	14
a prerequisite conformational state	14
b and t cell	14
was removed from the	14
lower than that of	14
small molecule inhibitors of	14
the primary binding site	14
sites under positive selection	14
protein for membrane fusion	14
the interaction with the	14
g c t g	14
c t t c	14
the case of sars	14
were carried out at	14
for the prevention and	14
conformational state for receptor	14
in at least of	14
a model of the	14
t cell and b	14
evolution of the sars	14
binding domain of sars	14
that the d g	14
is expected to be	14
was performed on a	14
risk of human transmission	14
the ratio of the	14
washed twice with pbs	14
was performed in the	14
the majority of these	14
candidate targets for immune	14
on the order of	14
the global spread of	14
was determined to be	14
were performed as described	14
was determined by the	14
in the middle east	14
with reduction to specific	14
activation of the severe	14
findings of this study	14
directly from clinical samples	14
prerequisite conformational state for	14
in the human adult	14
modified version of the	14
to the rest of	14
r s s c	14
as depicted in figure	14
is believed to be	14
of the coronavirus disease	14
remains to be determined	14
in order to investigate	14
served as a loading	14
be related to the	14
for min and then	14
were normalized to the	14
the existence of a	14
rounds of d classification	14
one of the three	14
a beat gesture on	14
s p g c	14
has also been reported	14
the severity of covid	14
the accuracy of the	14
will be required to	14
complex with its host	14
the th and th	14
is critical for the	14
may serve as a	14
ace is expressed in	14
as a source of	14
provides insights into the	14
from the ongoing wuhan	14
for hr at room	14
of orf a and	14
a high number of	14
differential expression analysis of	14
data are consistent with	14
as a proxy for	14
pathogenesis and transmission of	14
not appear to be	14
was no significant difference	14
as well as their	14
in the middle of	14
it is notable that	14
s subunit of sars	14
and incubated at room	14
t a c t	14
the bottom of the	14
the treatment of severe	14
sars and bat cov	14
in inflammatory bowel disease	14
a significant decrease in	14
cell and b cell	14
a coronavirus spike glycoprotein	14
target of neutralizing antibodies	14
as illustrated in figure	14
the time of writing	14
from human pluripotent stem	14
in complex with ace	14
cell subsets across tissues	14
responses in severe covid	14
coronavirus from malayan pangolins	14
respiratory syncytial virus infection	14
human neutralizing antibodies elicited	14
were then incubated with	14
we propose that the	14
wuhan outbreak and modeling	14
immunosequencing data with implanted	14
reveal a prerequisite conformational	14
antibodies elicited by sars	14
in the formation of	14
of cd t cell	14
coronavirus spike glycoprotein in	14
test the hypothesis that	14
was calculated as the	14
this is supported by	14
was carried out with	14
cpg and adj cpg	13
this study this study	13
to conformational changes induced	13
is given by the	13
and the cells were	13
characterization of the novel	13
the difference in the	13
that are involved in	13
s protein of the	13
are natural reservoirs of	13
and is detected in	13
is the causative agent	13
results of this study	13
specific t cell immunity	13
by receptor recognition or	13
and reduces viral control	13
cytopathic effect on vero	13
are shown in the	13
we were not able	13
against the s protein	13
and discovery of its	13
used to predict the	13
stabilized coronavirus spikes are	13
the spike proteins of	13
is very similar to	13
and the lack of	13
was not observed in	13
centrifuged at xg for	13
at the surface of	13
aerosol and surface stability	13
in the setting of	13
structure of the spike	13
highlight the importance of	13
as shown in the	13
these results support the	13
figure d and e	13
have no conflicts of	13
a variety of different	13
the exception of the	13
does not depend on	13
i interferon activity and	13
spike protein for membrane	13
monoclonal antibody blocking sars	13
the clinical and pathological	13
in addition to its	13
the foot placement mechanism	13
with an average of	13
cell gene expression data	13
coronavirus adaptation to human	13
respiratory syndrome coronavirus entry	13
was higher than that	13
to the secondary site	13
of human lung cells	13
mu and delta opioid	13
is well known that	13
the concentration of the	13
producing cd t cells	13
to contribute to the	13
receptor and viral determinants	13
available from the corresponding	13
for one hour at	13
images were acquired using	13
will be able to	13
caused by the sars	13
washed with pbs and	13
are presented as the	13
viral determinants of sars	13
to the s protein	13
species of the genus	13
surface stability of sars	13
and rapid transmission of	13
the receptor binding domains	13
cells were stained with	13
by the use of	13
and a negative control	13
the presence of increasing	13
target for vaccine and	13
that none of the	13
used to compute the	13
different parts of the	13
novel coronavirus spike protein	13
in an in vitro	13
revealed the presence of	13
and it has been	13
the s protein in	13
parallelism from laptops to	13
both cd and cd	13
in materials and methods	13
predict candidate targets for	13
discovery of its inhibitors	13
the trinity of covid	13
in balb c mice	13
spikes are resistant to	13
at a multiplicity of	13
patient with atypical pneumonia	13
significant increase in the	13
disease in china the	13
one of the first	13
and surface stability of	13
coronavirus spikes are resistant	13
has been found to	13
in the genomes of	13
identification of potential vaccine	13
and b cell epitopes	13
order to determine the	13
mice transgenic for human	13
pathogenic coronavirus isolated from	13
and viral determinants of	13
vivo and in vitro	13
protein is a class	13
are found to be	13
not present in the	13
public health emergency of	13
against middle east respiratory	13
shedding and increases infectivity	13
the development of effective	13
s shedding and increases	13
differentially expressed genes between	13
inflammatory responses in severe	13
the preprint server for	13
differentially expressed genes in	13
human airway epithelial cell	13
of the host immune	13
a review of the	13
regions of the genome	13
the presence of two	13
s subunit of the	13
viral entry into host	13
then added to the	13
by size exclusion chromatography	13
has been used to	13
we also examined the	13
from laptops to supercomputers	13
at xg for minutes	13
impaired type i interferon	13
table of the supplementary	13
at the center of	13
in the rbd of	13
is considered to be	13
protein receptor binding domain	13
and characterization of the	13
of the presence of	13
disease in china a	13
the prefusion conformation structural	13
in the peripheral blood	13
approach can predict candidate	13
here we report the	13
for rapid unsupervised cryo	13
we focus on the	13
china a pneumonia outbreak	13
performed according to the	13
fusion and reduces viral	13
did not result in	13
were performed as previously	13
we hypothesize that the	13
respiratory syndrome coronavirus replication	13
has been proposed as	13
of the new coronavirus	13
was used to assess	13
it is conceivable that	13
cells were seeded into	13
to the reference sequence	13
in a subset of	13
pneumonia in rhesus macaques	13
amino acid substitutions in	13
infection and rapid transmission	13
rbd binding to ace	13
adaptation to human ace	13
was used to predict	13
the number of samples	13
in all of the	13
is shown in table	13
receptor recognition or proteolysis	13
algorithms for rapid unsupervised	13
plays a critical role	13
blood was collected from	13
the ventral accessory calyx	13
on the s protein	13
pneumonia after visiting wuhan	13
control by the humoral	13
and treatment of covid	13
cells in the lung	13
to test the hypothesis	13
in line with our	13
structure and solvent accessibility	13
of the respiratory tract	13
characterization of the fusion	13
by the number of	13
of one of the	13
figures a and b	13
by the humoral immune	13
were fixed and stained	13
the results show that	13
type i interferon activity	13
multiple sequence alignment with	13
as determined by the	13
a and orf a	13
the cause of covid	13
concentration of mg ml	13
studies have suggested that	13
were selected for further	13
are resistant to conformational	13
high performance molecular simulations	13
a broad spectrum of	13
for vaccine and therapeutic	13
the reciprocal of the	13
the identification of the	13
the receptor binding motif	13
rna dependent rna polymerase	13
cells per well in	13
the sum of the	13
respiratory syndrome coronavirus protein	13
were performed in the	13
reverse transcription polymerase chain	13
has been observed in	13
infection of human lung	13
of the fusion core	13
by a factor of	13
nsp protein of sars	13
atypical pneumonia after visiting	13
the center of mass	13
the human protein atlas	13
cell entry of sars	13
the first and second	13
rapid transmission of sars	13
the s protein and	13
membrane fusion and reduces	13
at a dilution of	13
in a total of	13
in support of this	13
transcription polymerase chain reaction	13
as a measure of	13
reduces viral control by	13
immune response to sars	13
genomic characterization of the	13
s and table s	13
the statistical significance of	13
been shown that the	13
viral control by the	13
a patient with atypical	13
in the crystal structure	13
of a large number	13
performance molecular simulations through	13
on the use of	13
in agreement with our	13
at later time points	13
human monoclonal antibody blocking	13
incubated on ice for	13
the s subunit is	13
an increasing number of	13
by a human monoclonal	13
the orf b gene	13
severe cases of covid	13
a higher number of	13
the structure of a	13
the genome of sars	13
responsible for the covid	13
the ace binding site	13
respiratory syndrome coronavirus and	13
the potential to be	13
the unfolded protein response	13
of mutations in the	13
was associated with a	13
for the expression of	13
due to lack of	13
and the expression of	13
an order of magnitude	13
and severe acute respiratory	13
be one of the	13
the prediction of the	13
can predict candidate targets	13
t x n s	13
phylogenetic network analysis of	13
with atypical pneumonia after	13
the location of the	13
more than million people	13
induced by receptor recognition	13
resistant to conformational changes	13
were used as a	13
compared to the control	12
are unlikely to be	12
binding site of the	12
molecular simulations through multi	12
there is evidence that	12
that are associated with	12
very similar to the	12
s p g a	12
spiked into fresh human	12
insights into the origin	12
of acute lung injury	12
is referred to as	12
were washed with pbs	12
a human monoclonal sars	12
with the idea that	12
and protection from disease	12
ata atc atg att	12
it was shown that	12
protein via sequential proteolytic	12
were able to identify	12
interactive tree of life	12
structure of the s	12
were extracted from the	12
in the wild type	12
is linked to the	12
hepatitis c virus replication	12
sequential proteolytic cleavage at	12
the probability of a	12
local alignment search tool	12
productively infects human gut	12
tca tcc tcg tct	12
molecular biology of coronaviruses	12
at a final concentration	12
we found that a	12
a report of cases	12
t t t c	12
of the clinical and	12
at the top of	12
awake and drowsy trials	12
and pathological manifestations of	12
pellets were resuspended in	12
here we describe a	12
cells and is detected	12
were placed in the	12
were not included in	12
tools for molecular graphics	12
att cta ctc ctg	12
in their ability to	12
of sb and sb	12
antibodies and protection from	12
end of the genome	12
by a novel coronavirus	12
a fixed concentration of	12
rna sequencing of human	12
at the plasma membrane	12
c a t t	12
in combination with other	12
manifestations of coronavirus disease	12
changes in population size	12
molecular dynamics with namd	12
gcg gct tca tcc	12
and its role in	12
were incubated for hours	12
region of the spike	12
were tested for their	12
cct gca gcc gcg	12
of the effect of	12
in atcf l ko	12
pandemic of coronavirus disease	12
performed as described previously	12
in the frequency domain	12
to nsp and nsp	12
in a wide range	12
no effect on the	12
between the rbd and	12
and without a delay	12
analysis across computing platforms	12
in china a pneumonia	12
x viral copies ml	12
rbd of the s	12
in the structure of	12
an rna extraction step	12
ccc ccg cct gca	12
and pathogenesis of coronaviruses	12
which was found to	12
with a range of	12
in the genome of	12
in order to make	12
as a basis for	12
s s and s	12
shown in table s	12
in all three viruses	12
surface area of the	12
have been deposited in	12
to be used in	12
into fresh human saliva	12
protein of the sars	12
related coronavirus from malayan	12
genome sequences of sars	12
the national institute of	12
detected in specific cell	12
has been demonstrated to	12
ccg cct gca gcc	12
crucial role of angiotensin	12
em structure determination in	12
the minimum number of	12
time step of fs	12
of regulatory t cells	12
the molecular basis for	12
gcc gcg gct tca	12
and dispersion for rna	12
a class i virus	12
neutralizing antibodies and protection	12
for macromolecular structure solution	12
was determined using the	12
also be used to	12
the mechanism by which	12
for each amino acid	12
gtc gtg gtt tta	12
protection from disease in	12
are provided in the	12
of an inactivated vaccine	12
in the general population	12
genomic characterization of a	12
outbreak of severe acute	12
study this study this	12
at a minimum of	12
of human monoclonal antibodies	12
is a potent inhibitor	12
i cd t cells	12
t a t y	12
of the current pandemic	12
of the s trimer	12
the understanding of the	12
in a number of	12
is present in the	12
cca ccc ccg cct	12
of potential vaccine targets	12
rbd in complex with	12
supernatant was removed and	12
in the endoplasmic reticulum	12
these results are consistent	12
system for macromolecular structure	12
the first or second	12
in dmem supplemented with	12
the first and last	12
read alignment with bowtie	12
cells were maintained in	12
seq data with deseq	12
efficacy and safety of	12
is based on a	12
in a small animal	12
cta ctc ctg ctt	12
activates the nlrp inflammasome	12
experiments were carried out	12
in human and mouse	12
ctg ctt gta gtc	12
in good agreement with	12
the synthesis of the	12
incubated at o c	12
origin of the virus	12
the side chain of	12
the n gene assay	12
proteolytic cleavage at two	12
the fusion core complex	12
were used in this	12
the same way as	12
is detected in specific	12
a a g a	12
structure determination in relion	12
the scope of this	12
in the lungs and	12
development of an inactivated	12
cleavage at two distinct	12
the left and right	12
scalable molecular dynamics with	12
clinical and pathological manifestations	12
ctc ctg ctt gta	12
the crystal structures of	12
of the rbd of	12
new tools for automated	12
at two distinct sites	12
the relative abundance of	12
to the active site	12
level parallelism from laptops	12
pathological manifestations of coronavirus	12
of influenza a viruses	12
infects human gut enterocytes	12
comprehensive integration of single	12
of t cells in	12
added to the cells	12
in hospitalized patients with	12
that the s protein	12
from the gisaid database	12
gtg gtt tta ttc	12
of gene expression in	12
the disease caused by	12
atc atg att cta	12
to the viral genome	12
isolation of potent sars	12
plays a key role	12
in the amount of	12
assays for the detection	12
via sequential proteolytic cleavage	12
has emerged as a	12
this led us to	12
health emergency of international	12
the same as in	12
of a recombinant adenovirus	12
of the influenza virus	12
glucose uptake in the	12
no significant difference between	12
have been associated with	12
s p c c	12
and the emergence of	12
allowed us to identify	12
that bind to the	12
used to identify the	12
is expressed in the	12
and the percentage of	12
this is due to	12
in the analysis of	12
the development of the	12
play a crucial role	12
play important roles in	12
ctt gta gtc gtg	12
were performed on the	12
class i virus fusion	12
the calculation of the	12
act cca ccc ccg	12
be susceptible to sars	12
in the viral life	12
the recent emergence of	12
to the formation of	12
for the prevention of	12
atg att cta ctc	12
type i interferon responses	12
the mrna expression of	12
tools for automated high	12
were cloned into the	12
viral and cellular membranes	12
similar results were obtained	12
the spike protein is	12
in order to avoid	12
bats are natural reservoirs	12
gca gcc gcg gct	12
the viral genome and	12
a comparison of the	12
center of mass of	12
with the results of	12
analysis was performed by	12
at different stages of	12
the detection of the	12
in hace transgenic mice	12
compared to that of	12
in this study was	12
of the epidemic in	12
the superior lateral protocerebrum	12
to the a bp	12
expression profile of ace	12
the supernatant was removed	12
presented in this study	12
in light of the	12
gtt tta ttc ttg	12
with the goal of	12
results are shown in	12
pandemic caused by sars	12
total rna was extracted	12
a wide spectrum of	12
the amber force field	12
an equal volume of	12
associated with disease severity	12
is similar to that	12
network analysis of sars	12
play a key role	12
identify cell types and	12
compared to the wild	12
it can be used	12
prefusion conformation structural basis	12
comparable to that of	12
be seen in figure	12
it has been proposed	12
of transcranial magnetic stimulation	12
a t t a	12
a crucial role of	12
performed using graphpad prism	12
building tools for molecular	12
a unique opportunity to	12
are summarized in table	12
the indicated time points	12
binding to the rbd	12
a second round of	12
protein secondary structure and	12
natural reservoirs of sars	12
functional analysis of the	12
tens of thousands of	12
the spread of sars	12
the prevention and treatment	12
t c a t	12
by human monoclonal antibodies	12
of reads mapping to	12
have an impact on	12
in order to obtain	12
given in table a	12
have not yet been	12
h n influenza a	12
sars coronavirus nucleocapsid protein	12
the presence of nsp	12
would be expected to	12
to the s subunit	12
evolutionary genetics analysis across	12
t a t g	12
of the pulmonary surfactant	12
and can be used	12
basic local alignment search	12
the pathogenicity of sars	12
an observational cohort study	12
terminal domain of the	12
the new york city	12
room temperature for min	12
reads were mapped to	12
the wild type and	12
on the one hand	12
conformational changes in the	12
an in vitro model	12
role of angiotensin converting	12
the first time that	12
a significant role in	12
would like to acknowledge	12
due to differences in	12
at a dose of	12
gta gtc gtg gtt	12
that could be used	12