This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-001674-tp4o7fxx | I molecules at all? |
| cord-267567-w39f584z | Early dengue virus protein synthesis induces extensive rearrangement of the endoplasmic reticulum independent of the UPR and SREBP-2 pathway Bacterial membrane lipids: where do we stand? |
| cord-268501-z4oztgi0 | , Clarisa B. title: What Would Jenner and Pasteur Have Done About COVID-19 Coronavirus? |
| cord-261367-i1n8x0uc | Lymphoid follicles in( very) severe COPD: beneficial or harmful? |
| cord-268781-6l74rrlm | How do cytotoxic lymphocytes kill cancer cells? |
| cord-003378-0ozhye9q | Uteroglobin: a novel cytokine? |
| cord-003368-f8f2utzx | the example of Bovine Neonatal Pancytopenia Case control study to investigate risk factors for bovine neonatal pancytopenia( BNP) in young calves in southern Germany Bovine neonatal pancytopenia: is this alloimmune syndrome caused by vaccine- induced alloreactive antibodies? |
| cord-257662-viy65y72 | tumor associated macrophages suppress antitumor T cell responses Myeloid- derived suppressor cells: the dark knight or the joker in viral infections? |
| cord-259748-x7dq1sy4 | interferon response reduces microglial reactivity and neuroinflammation Modulation of the immune system by UV radiation: more than just the effects of vitamin D? |
| cord-003656-7mzsaz7a | isolated from Struthio camelus Mycoplasmas and their host: emerging and re- emerging minimal pathogens Antibiotic residues in food: the African scenario DNA- antiviral vaccines: New developments and approaches- a review Immunization of animals: from DNA to the dinner plate DNA vaccines: an historical perspective and view to the future DNA vaccines: ready for prime time? |
| cord-255578-0ltb9dpa | Is the complement activation product C3a a proinflammatory molecule? |
| cord-268511-dx2cqqt5 | The membrane- bound mucin Muc1 regulates T helper 17-cell responses and colitis in mice Cutting edge: transgenic expression of human MUC1 in IL-10-/-mice accelerates inflammatory bowel disease and progression to colon cancer Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O- glycans IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis Expression of IL-24, an activator of the JAK1/ STAT3/ SOCS3 cascade, is enhanced in inflammatory bowel disease Matrix metalloproteinase MMP9 maintains epithelial barrier function and preserves mucosal lining in colitis associated cancer ECM remodelling in IBD: innocent bystander or partner in crime? |
| cord-020770-wpub7krf | A polarizing question: do M1 and M2 microglia exist? |
| cord-030803-6i0e2zkd | Innate lymphoid cells- how did we miss them? |
| cord-030803-6i0e2zkd | and Th9 in parasite immunity Human mast cell subsets- distinct functions in inflammation? |
| cord-267237-wbwlfx7q | Front Immunol Recommendations for the management of hemophagocytic lymphohistiocytosis in adults Virus- associated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A( H1N1) infection Is secondary hemophagocytic lymphohistiocytosis behind the high fatality rate in Middle East respiratory syndrome corona virus? |
| cord-265855-zf52vl11 | A public health problem? |
| cord-265855-zf52vl11 | Chloroquine is a zinc ionophore New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? |
| cord-283505-ousbar6c | the interplay between host and pathogen Influenza at the Human- Animal Interface: Summary and Assessment A highly pathogenic avian H7N9 influenza virus isolated from a human is lethal in some ferrets infected via respiratory droplets Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8? |
| cord-034310-izpt032p | Innate and adaptive immunity in the pathogenesis of atherosclerosis Antigen- Induced Immunomodulation in the pathogenesis of atherosclerosis T cell subsets and functions in atherosclerosis Autoimmunity in atherosclerosis: a protective response losing control? |
| cord-034310-izpt032p | Keratin 8 is a potential self- antigen in the coronary artery disease immunopeptidome: a translational approach Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co- morbid conditions Psoriasis and atherosclerosis: two plaques, one syndrome? |
| cord-030385-btf502ju | Biomarkers of sepsis Two decades of mortality trends among patients with severe sepsis: a comparative meta- analysis Incidence and trends of sepsis in US hospitals using clinical vs claims data Biomarker cruises in sepsis: who is the CAPTAIN? |
| cord-030385-btf502ju | catabolism syndrome Penkid: a novel biomarker of reduced GFR in sepsis Adaptation of a biomarker- based sepsis mortality risk stratification tool for pediatric acute respiratory distress syndrome Reconsidering lactate as a sepsis risk biomarker Gender differences in sepsis: genetically determined? |
| cord-003122-a3f4l6iu | How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin Immunogen design for HIV-1 and influenza Is it possible to develop a"universal"influenza virus vaccine? |
| cord-003122-a3f4l6iu | neuraminidases Neuraminidase receptor binding variants of human influenza A(H3N2) viruses resulting from substitution of aspartic acid 151 in the catalytic site: a role in virus attachment? |
| cord-000647-uofygmeu | Could the lower frequency of CD8+CD18+CD45RO+ lymphocytes be biomarkers of human VL? |
| cord-000647-uofygmeu | authors: Stäger, Simona; Rafati, Sima title: CD8(+) T Cells in Leishmania Infections: Friends or Foes? |
| cord-303017-4zx94rm6 | Individuals Beta- blockers: Friend or foe in asthma? |
| cord-291941-9a4tt4f7 | The biology and functional importance of MAIT cells MAIT cells come to the rescue in cancer immunotherapy? |
| cord-304626-ffao7vka | Fibronectin binds to the C1q component of complement New functional ligands for ficolin-3 among lipopolysaccharides of Hafnia alvei Heteromeric Complexes of native collectin kidney 1 and collectin liver 1 are found in the circulation with MASPs and activate the complement system Proteolytic activities of two types of mannose- binding lectin- associated serine protease Natural substrates and inhibitors of mannan- binding lectin- associated serine protease-1 and−2: a study on recombinant catalytic fragments MASP-3 and its association with distinct complexes of the mannanbinding lectin complement activation pathway C3 adsorbed to a polymer surface can form an initiating alternative pathway convertase The tick- over theory revisited: is C3 a contactactivated protein? |
| cord-298604-tn8hc6jv | The mercurial nature of neutrophils: still an enigma in ARDS? |
| cord-280941-ds6x0yym | How will HPV vaccines affect cervical cancer? |
| cord-280941-ds6x0yym | The composition and the structure of bacterioferritin of Escherichia coli Self- assembly in the ferritin nano- cage protein superfamily Presenting native- like trimeric HIV-1 antigens with self- assembling nanoparticles Hemagglutinin- stem nanoparticles generate heterosubtypic influenza protection Ferritin nanocages: great potential as clinically translatable drug delivery vehicles? |
| cord-312074-0nqmjdek | Specific localization of membrane dipeptidase and dipeptidyl peptidase IV in secretion granules of two different pancreatic islet cells Natural killer cell cytotoxicity: how do they pull the trigger? |
| cord-312955-gs65c3fy | This raises the question of why the innate immune system fails to combat SARS- CoV-2? |
| cord-253862-jl1zhg13 | Teicoplanin: an alternative drug for the treatment of COVID-19? |
| cord-253862-jl1zhg13 | what next? |
| cord-267134-5gz2dotn | Could BCG vaccination induce protective trained immunity for SARS- CoV-2? |
| cord-267134-5gz2dotn | Host signaling and proteolytic pathways in the resolution or the exacerbation of coronavirus( CoV-2) infection in COVID-19 disease: what therapeutic targets? |
| cord-267134-5gz2dotn | Innate Immune Signaling and Proteolytic Pathways in the Resolution or Exacerbation of SARS- CoV-2 in Covid-19: Key Therapeutic Targets? |
| cord-003091-uvfppirt | Eradicating infectious disease: can we and should we? |
| cord-003091-uvfppirt | What is missing? |
| cord-003091-uvfppirt | Why do n't we have an effective tuberculosis vaccine yet? |
| cord-256582-x2grfhov | Distinct regulation of dengue virus- induced inflammasome activation in human macrophage subsets CLEC5A- mediated enhancement of the inflammatory response in myeloid cells contributes to influenza virus pathogenicity in vivo Induction of proinflammatory cytokines in human macrophages by influenza A( H5N1) viruses: a mechanism for the unusual severity of human disease? |
| cord-255034-x100xo2t | However, what about the therapeutic indication of NK cells in infectious diseases in general and in the lungs particularly? |
| cord-255034-x100xo2t | Most of the papers discussed above investigated the NK cell cytotoxicity toward autologous cells or conventional NK target cells, but what about a potential direct bacterial killing? |
| cord-255034-x100xo2t | the forgotten population Harnessing innate immunity in cancer therapy NK cell education via nonclassical MHC and non- MHC ligands Natural killer cell education and the response to infection and cancer therapy: stay tuned Unlicensed'natural killer cells dominate the response to cytomegalovirus infection Use of CAR- transduced natural killer cells in CD19-positive lymphoid tumors NK cell- mediated recall responses: memory- like, adaptive, or antigen- specific? |
| cord-323756-atnrw9ew | Approaching the asymptote? |
| cord-273277-4ewvwg4o | preclinical focus on CNS International Group for The Study of Lithium Treated, Lithium's antiviral effects: a potential drug for CoViD-19 disease? |
| cord-273277-4ewvwg4o | to counter the pandemic, clinicians bank on repurposed drugs Analysis of therapeutic targets for SARS- CoV-2 and discovery of potential drugs by computational syndrome coronavirus nucleocapsid protein and viral replication Identification of phosphorylation sites in the nucleocapsid protein( N protein) of SARS- coronavirus Inhibition of cell proliferation by SARS- CoV infection in Vero E6 cells Structure of M(pro) from SARS- CoV-2 and discovery of its inhibitors The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor Glycogen synthase kinase 3: a kinase for all pathways? |
| cord-318418-uqxzds6g | In vitro evaluation of single- and multi- strain probiotics: inter- species inhibition between probiotic strains, and inhibition of pathogens Health benefits of probiotics: are mixtures more effective than single strains? |
| cord-269222-g2ibmo75 | Bacterial vaginosis is a strong predictor of Neisseria gonorrhoeae and Chlamydia trachomatis infection Bacterial vaginosis( BV) and the risk of incident gonococcal or chlamydial genital infection in a predominantly black population Bacterial vaginosis, race, and sexually transmitted infections: does race modify the association? |
| cord-269222-g2ibmo75 | The vaginal microbiome: new information about genital tract flora using molecular based techniques Vaginal microbiome of reproductive- age women Lactobacillus iners: friend or foe? |
| cord-267166-ecmayzr6 | Can both populations display protective functions? |
| cord-267166-ecmayzr6 | Do they display dynamic functions throughout the evolution of MS lesions? |
| cord-003685-jcvrqeew | Tursiops truncatus) Evaluation of immune and stress status in harbour porpoises( Phocoena phocoena): can hormones and mRNA expression levels serve as indicators to assess stress? |
| cord-304623-j9ay4jkf | Cats are not small dogs: is there an immunological explanation for why cats are less affected by arthropod- borne disease than dogs? |
| cord-304623-j9ay4jkf | The long view: a bright past, a brighter future? |
| cord-300429-b0zev8zb | The role of MPP1/ p55 and its palmitoylation in resting state raft organization in HEL cells Membrane raft association is a determinant of plasma membrane localization Palmitoylated transmembrane adaptor proteins in leukocyte signaling Interaction of influenza virus haemagglutinin with sphingolipid- cholesterol membrane domains via its transmembrane domain What does S- palmitoylation do to membrane proteins? |
| cord-300429-b0zev8zb | are enzymes for fatty acid attachment promising drug targets? |
| cord-306600-cxz8hf9q | The co- pathogenesis of influenza viruses with bacteria in the lung Mucosal administration of flagellin induces innate immunity in the mouse lung Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type response Lung epithelial cells: therapeutically inducible effectors of antimicrobial defense Lung epithelial MyD88 drives early pulmonary clearance of Pseudomonas aeruginosa by a flagellin dependent mechanism Understanding the pneumococcus: transmission and evolution Antibiotic resistance and its cost: is it possible to reverse resistance? |
| cord-306600-cxz8hf9q | When does 2 plus 2 equal 5? |
| cord-340475-h0q1m3ed | This raises the question why the infection persist in spite of increased levels of antiviral factors? |
| cord-305936-tdswzj7r | Is influenza- like illness a useful concept and an appropriate test of influenza vaccine effectiveness? |
| cord-256998-or73in8m | After initial setback, IL-12 regaining popularity Interleukin 12: still a promising candidate for tumor immunotherapy? |
| cord-256998-or73in8m | Gamma interferon enhances macrophage transcription of the tumor necrosis factor/ cachectin, interleukin 1, and urokinase genes, which are controlled by short- lived repressors Interferon and major histocompatibility complex genes: a model to analyse eukaryotic gene regulation? |
| cord-256998-or73in8m | The molecular pathogenesis of semliki forest virus: a model virus made useful? |
| cord-274557-2071770h | Antired blood cell antibodies, free light chains, and antiphospholipid antibodies in intravenous immunoglobulin preparations Soluble HLA class I and class II concentrations in commercial immunoglobulin preparations High- dose intravenous immunoglobulin treatment and cerebral vasospasm: a possible mechanism of ischemic encephalopathy? |
| cord-274557-2071770h | Do we have autoantibodies? |
| cord-313227-6zwkfzab | An overview on medicinal perspective of thiazolidine-2,4-dione: a remarkable scaffold in the treatment of type 2 diabetes TNF- alpha and inflammatory cytokines and risk of type 2 diabetes: a systematic review and meta- analysis Selective insulin resistance and the development of cardiovascular diseases in diabetes: the 2015 edwin bierman award lecture Can pioglitazone be potentially useful therapeutically in treating patients with COVID-19? |
| cord-313227-6zwkfzab | are we already that far? |
| cord-275779-ocbygkyb | Human seasonal influenza A viruses induce H7N9-cross- reactive antibodydependent cellular cytotoxicity( ADCC) antibodies that are directed towards the nucleoprotein Similarity and divergence in the development and expression of the mouse and human antibody repertoires Of mice and not men: differences between mouse and human immunology Transitional B cells: how well are the checkpoints for specificity understood? |
| cord-275779-ocbygkyb | NK cell- mediated ADCC tip the scales? |
| cord-262944-9k64f0tw | : what can we learn from circulating NK lymphocytes? |
| cord-262944-9k64f0tw | An invisible enemy? |
| cord-262944-9k64f0tw | T cells protect against Zika virus during pregnancy Zika virus shedding in human milk during lactation: an unlikely source of infection? |
| cord-262944-9k64f0tw | What is the placenta? |
| cord-293736-nyvwv31m | : can we go from bench to bedside? |
| cord-293736-nyvwv31m | An update on immune dysregulation in obesity- related insulin resistance Adipokines and inflammation: is it a question of weight? |
| cord-293736-nyvwv31m | COVID-19 pneumonia: ARDS or not? |
| cord-318630-h6j7iqbm | B- Cell interactions in MS/ eAe? |
| cord-318630-h6j7iqbm | Strong EBV- specific CD8+ T- cell response in patients with early multiple sclerosis High- throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV- reactive CD8+ T cells Epstein- Barr virus- specific adoptive immunotherapy: a new horizon for multiple sclerosis treatment? |
| cord-350041-b1vmnwv2 | Suggesting a Connection? |
| cord-342776-hkjhqgie | The involvement of natural killer cells in the pathogenesis of severe acute respiratory syndrome Dysregulation of immune response in patients with COVID-19 in Wuhan, China Editorial overview: tumour immunology: are we on the path to win the battle against cancer through immunotherapy? |
| cord-296585-yfh5d4io | IL-33 expression in chronic obstructive pulmonary disease Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease Antielastin autoimmunity in tobacco smoking- induced emphysema Antiendothelial cell antibodies in patients with COPD Autoantibodies in patients with chronic obstructive pulmonary disease Neutrophil priming by cigarette smoke condensate and a tobacco anti- idiotypic antibody Identification of cytokeratin 18 as a bronchial epithelial autoantigen associated with nonallergic asthma Autoimmunity, T- cells and STAT-4 in the pathogenesis of chronic obstructive pulmonary disease Hypothesis: does COPD have an autoimmune component? |
| cord-296585-yfh5d4io | Is the acquired immune system required? |
| cord-296585-yfh5d4io | The co- pathogenesis of influenza viruses with bacteria in the lung Viral- bacterial interactions in the respiratory tract Viral, bacterial or both? |
| cord-280605-2i4gk7et | A SYSDIET Sub- Study Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? |
| cord-280605-2i4gk7et | Do You Remember Mitochondria? |
| cord-280605-2i4gk7et | What is a healthy Nordic diet? |
| cord-280605-2i4gk7et | attenuates atherosclerotic plaque formation in diet and inflammation- induced atherogenesis Human CNS immune senescence and neurodegeneration Microglial senescence: does the brain's immune system have an expiration date? |
| cord-348283-7xorq5ce | Can we contain the COVID-19 outbreak with the same measures as for SARS? |
| cord-348283-7xorq5ce | Does urbanization make emergence of zoonosis more likely? |
| cord-297960-4x1j0iqg | : can we ever expect the unexpected? |
| cord-297960-4x1j0iqg | How Do intrinsically disordered viral proteins hijack the cell? |
| cord-307813-elom30nx | A decoy peptide that disrupts TIRAP recruitment to TLRs is protective in a murine model of influenza Novel strategies for targeting innate immune responses to influenza Highly pathogenic avian influenza A H5N1 and pandemic H1N1 virus infections have different phenotypes in toll- like receptor 3 knockout mice Inhibition of toll- like receptor signaling as a promising therapy for inflammatory diseases: a journey from molecular to nano therapeutics Small- molecule inhibitors of the TLR3/ dsRNA complex Radix isatidis polysaccharides inhibit influenza a virus and influenza A virus- induced inflammation via suppression of Host TLR3 signaling in vitro Novel effect of methionine enkephalin against influenza A virus infection through inhibiting TLR7-MyD88-TRAF6-NF- kappaB p65 signaling pathway Influenza virus and glycemic variability in diabetes: a killer combination? |
| cord-307813-elom30nx | Innate lymphoid cells in asthma: will they take your breath away? |
| cord-307813-elom30nx | a mechanism for the unusual severity of human disease? |
| cord-003598-m2fsrwvw | Innate immune responses to influenza A H5N1: friend or foe? |
| cord-003598-m2fsrwvw | Old drugs losing effectiveness against flu; could statins fill gap? |
| cord-282081-qaagup4d | : cord-282081-qaagup4d authors: Flicker, Sabine; Zettl, Ines; Tillib, Sergei V. title: Nanobodies — Useful Tools for Allergy Treatment? |
| cord-282081-qaagup4d | Can the nanobody technology provide enhanced opportunity to generate a panel of antigen- binding molecules with various epitope specificities for certain allergens different to conventional antibodies? |
| cord-282081-qaagup4d | IgG revisited Passive immunization with allergen- specific antibodies Pricing of monoclonal antibody therapies: higher if used for cancer? |
| cord-282081-qaagup4d | Will it be possible with this technology to find single nanobodies that are able to abrogate IgE- mediated allergic inflammation? |
| cord-282081-qaagup4d | Will these identified allergen- specific nanobodies be more efficient in blocking than conventional IgG antibodies due to their pronounced cleft recognition? |
| cord-316702-dj2fo8sn | Do superspreaders generate new superspreaders? |
| cord-316702-dj2fo8sn | The Problem of Herd- Immunity Herd immunity: history, theory, practice Herd immunity": a rough guide Vaccination and herd immunity: what more do we know? |
| cord-316702-dj2fo8sn | cord-316702-dj2fo8sn authors: Vignesh, Ramachandran; Shankar, Esaki M.; Velu, Vijayakumar; Thyagarajan, Sadras Panchatcharam title: Is Herd Immunity Against SARS- CoV-2 a Silver Lining? |
| cord-353594-z1vxamvp | COVID-19: risk for cytokine targeting in chronic inflammatory diseases? |
| cord-353594-z1vxamvp | PR3 and MPO antigen microdots improve the laboratory diagnostics of ANCA- associated vasculitis From ANA to ENA: how to proceed? |
| cord-328003-yovp8squ | What Are the Most Powerful Immunogen Design Vaccine Strategies? |
| cord-328003-yovp8squ | What Are the Most Powerful Immunogen Design Vaccine Strategies? |
| cord-328763-hcbs20a0 | Producing GM- CSF: a unique T helper subset? |
| cord-328763-hcbs20a0 | Why did IL-12/ IL-23 antibody therapy fail in multiple sclerosis? |
| cord-333041-69n2wwn3 | Can atmospheric pollution be considered a co- factor in extremely high level of SARS- CoV-2 lethality in Northern Italy? |
| cord-333041-69n2wwn3 | Specialized pro- resolving lipid mediators regulate ozone- induced pulmonary and systemic inflammation Exacerbation of nanoparticle- induced acute pulmonary inflammation in a mouse model of metabolic syndrome Inflammation resolution: a dual- pronged approach to averting cytokine storms in COVID-19? Pro- resolving lipid mediators are leads for resolution physiology SARS- CoV-2 infection: |
| cord-333041-69n2wwn3 | The specialized proresolving mediator 17-HDHA enhances the antibody- mediated immune response against influenza virus: a new class of adjuvant? |
| cord-272491-a84pahdr | I IFN and TNF responses in endothelial cells Is a"Cytokine storm"relevant to COVID-19? |
| cord-272491-a84pahdr | The role of mitochondrial dysfunction in sepsis- induced multiorgan failure Nexus between extracellular vesicles, immunomodulation and tissue remodeling: for good or for bad? |
| cord-272491-a84pahdr | cell- derived extracellular vesicles attenuate influenza virus- induced acute lung injury in a pig model Mesenchymal stem cells- derived extracellular vesicles in acute respiratory distress syndrome: a review of current literature and potential future treatment options Exosomes derived from endothelial progenitor cells ameliorate acute lung injury by transferring miR-126 Extracellular vesicles derived from mesenchymal stromal cells: a therapeutic option in respiratory diseases? |
| cord-272491-a84pahdr | clot formation Are therapeutic human mesenchymal stromal cells compatible with human blood? |
| cord-277529-z2r14w2k | Anti- IL1 treatment in colchicine- resistant paediatric FMF patients: real life data from the HELIOS registry Repositioning PARP inhibitors for SARS- CoV-2 infection( COVID-19); a new multi- pronged therapy for ARDS? |
| cord-277529-z2r14w2k | Cytokine and anticytokine interventions Colchicine may not be effective in COVID-19 infection; it may even be harmful? |
| cord-277529-z2r14w2k | Lapping or biting? |
| cord-277529-z2r14w2k | Should we stimulate or suppress immune responses in COVID-19? |
| cord-277529-z2r14w2k | cord-277529-z2r14w2k authors: Stella, Alessandro; Lamkanfi, Mohamed; Portincasa, Piero title: Familial Mediterranean Fever and COVID-19: Friends or Foes? |
| cord-273505-pcsw3vmx | A possible role for B cells in COVID-19? |
| cord-273505-pcsw3vmx | Impaired inhibitory Fcgamma receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy Recapitulation of IVIG anti- inflammatory activity with a recombinant IgG Fc Identification of a receptor required for the anti- inflammatory activity of IVIG Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway Intravenous immunoglobulin therapy: how does IgG modulate the immune system? |
| cord-273505-pcsw3vmx | Tregitope update: mechanism of action parallels IVIg Mechanisms of immune regulation by IVIG Tregitope peptides: the active pharmaceutical ingredient of IVIG? |
| cord-273505-pcsw3vmx | an operational recommendation of Peking Union Medical College Hospital Is dosing of therapeutic immunoglobulins optimal? |
| cord-340741-bhxm4zua | How good is automated protein docking? |
| cord-340741-bhxm4zua | why today? |
| cord-332150-j76726no | : what does viral RNA load really mean? |
| cord-332150-j76726no | A dynamic COVID-19 immune signature includes associations with poor prognosis Tocilizumab for cytokine storm syndrome in COVID-19 pneumonia: an increased risk for candidemia? |
| cord-332150-j76726no | A first step in understanding SARS pathogenesis ACE2 at the centre of COVID-19 from paucisymptomatic infections to severe pneumonia Clinical features of patients infected with 2019 novel coronavirus in Wuhan Longitudinal analyses reveal immunological misfiring in severe COVID-19 Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity Viral dynamics in mild and severe cases of COVID-19 The role of interleukin 6 during viral infections Inflammasomes and Pyroptosis as Therapeutic Targets for COVID-19 The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19? |
| cord-332150-j76726no | Should we stimulate or suppress immune responses in COVID-19? |
| cord-320431-0877trhh | : how might its expression define plasma cell development? |
| cord-320431-0877trhh | Bronchial epithelial cells: The key effector cells in the pathogenesis of chronic obstructive pulmonary disease? |
| cord-320431-0877trhh | not proinflammatory cytokines Role of double- stranded RNA pattern recognition receptors in rhinovirus- induced airway epithelial cell responses Dynamic cross talk model of the epithelial innate immune response to double- stranded RNA stimulation: coordinated dynamics emerging from cell- level noise Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double- stranded RNA responsiveness in airway epithelial cells Cutting Edge: Influenza A virus activates TLR3-dependent inflammatory and RIG- I- dependent antiviral responses in human lung epithelial cells Airway epithelial versus immune cell Stat1 function for innate defense against respiratory viral infection Activation of Toll- like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2 RAGE and TLRs: relatives, friends or neighbours? |
| cord-268483-joiajgs4 | : what to expect for COVID-19? |
| cord-268483-joiajgs4 | : where are we? |
| cord-268483-joiajgs4 | Chloroquine is a potent inhibitor of SARS coronavirus infection and spread Effects of chloroquine on viral infections: an old drug against today's diseases? |
| cord-268483-joiajgs4 | Clinical features of patients infected with 2019 novel coronavirus in Wuhan A phase 3, single- arm, prospective study of remestemcel- l, ex vivo culture- expanded adult human mesenchymal stromal cells for the treatment of pediatric patients who failed to respond to steroid treatment for acute graft- versus- host disease Remestemcel- L: Human mesenchymal stem cells as an emerging therapy for Crohn's disease Transplantation of ACE2-mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia Mesoblast To Evaluate Anti- Inflammatory Cell Therapy Remestemcel- L for Treatment of Covid-19 Lung Disease Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-350492-1s6wtj25 | A pneumonia outbreak associated with a new coronavirus of probable bat origin Are children less susceptible to COVID-19? |
| cord-350492-1s6wtj25 | Sars- coronavirus-2 trigger autoimmune and/or autoinflammatory mechanisms in genetically predisposed subjects? |
| cord-350492-1s6wtj25 | The Genotype- Tissue Expression( GTEx) pilot analysis: multitissue gene regulation in humans Macrophage activation syndrome in the era of biologic therapy Advances in immunopathogenesis of macrophage activation syndrome during rheumatic inflammatory diseases: toward new therapeutic targets? |
| cord-350492-1s6wtj25 | Very high serum ferritin levels are associated with increased mortality and critical care in pediatric patients Hyperferritinemia in the critically ill child with secondary hemophagocytic lymphohistiocytosis/ sepsis/ multiple organ dysfunction syndrome/ macrophage activation syndrome: what is the treatment? |
| cord-278081-tk7vn1v1 | And what is the distribution and composition of RNAs and proteins in nucleolar fragments compared to intact nucleoli? |
| cord-278081-tk7vn1v1 | And, perhaps most important, what does this new hypothesis present as far as therapeutic targets? |
| cord-278081-tk7vn1v1 | For example, what is the effect of acetylated polyamines if they were to compete with spermidine and spermine in the nucleolar folding and assembly of RNPs? |
| cord-278081-tk7vn1v1 | Is it, for example, a conformational alteration of the ribosomal subunits stabilized by polyamines, or incomplete assembly of an RNP? |
| cord-278081-tk7vn1v1 | SSA/ Ro bound to misfolded RNAs stabilized with polyamines that prevent proper refolding? |
| cord-278081-tk7vn1v1 | What are the interactions and resulting structures of intronic Alu RNA with nucleolin? |
| cord-269170-9f460xbq | Active or recent parvovirus B19 infection in children with kawasaki disease Kawasaki disease and human bocavirus- potential association? |
| cord-269170-9f460xbq | Epstein- barr virus genome- positive tubulointerstitial nephritis associated with kawasaki disease- like coronary aneurysms Could a herpesvirus be the cause of kawasaki disease? |
| cord-269170-9f460xbq | The etiology of kawasaki disease: retrovirus? |
| cord-269170-9f460xbq | Toxic shock syndrome toxin- secreting Staphylococcus aureus in kawasaki syndrome Polyclonal expansion of TCRBV2-and TCRBV6-bearing T cells in patients with kawasaki disease Cytokine polymorphisms have a synergistic effect on severity of the acute sickness response to infection Kawasaki disease- specific molecules in the sera are linked to microbeassociated molecular patterns in the biofilms Mycoplasma pneumoniae: a possible trigger of kawasaki disease or a mere coincidental association? |
| cord-269170-9f460xbq | What factors perturb the gut microbiota and cause dysbiosis in young children? |
| cord-269170-9f460xbq | toxin-1 may protect infants younger than 6 months of age from developing kawasaki syndrome Kawasaki disease: what is the epidemiology telling us about the etiology? |
| cord-321568-okvt1fg3 | Could an endo- lysosomal ion channel be the Achilles heel of SARS- CoV2? |
| cord-321568-okvt1fg3 | The fate of naringin in humans: a key to grapefruit juice- drug interactions? |
| cord-321568-okvt1fg3 | What is COVID-19? |
| cord-321568-okvt1fg3 | medRxiv Protective effects of naringenin in a rat model of sepsis- triggered acute kidney injury via activation of antioxidant enzymes and reduction in urinary angiotensinogen Does consumption of red grapefruit juice alter naringenin concentrations in milk produced by breastfeeding mothers? |
| cord-312438-zr9zx7pv | Does the human placenta express the canonical cell entry mediators for SARS- CoV-2? |
| cord-312438-zr9zx7pv | How can pathogens cross the SCT barrier and the VCT to infect the villous stroma? |
| cord-312438-zr9zx7pv | What is trophoblast? |
| cord-312438-zr9zx7pv | how do different pathogens escape or modulate the maternal- fetal host innate immune barrier( ii) why do some pathogens lead to congenital infection but not others? |
| cord-352150-ey9kc7zj | A very high level of crossreactivity is an essential feature of the T- cell receptor Why must T cells be cross- reactive? |
| cord-352150-ey9kc7zj | its orientation in the TCR- MHC complex T cell antigen receptor recognition of antigen- presenting molecules Reconciling views on T cell receptor germline bias for MHC A T cell receptor V beta segment that imparts reactivity to a class II major histocompatibility complex product T cell receptor reversed polarity recognition of a self- antigen major histocompatibility complex Hypothesis: why do so many lymphocytes respond to major histocompatibility antigens? |
| cord-353887-f4yd7guj | Intravenous immunoglobulin therapy: how does IgG modulate the immune system? |
| cord-353887-f4yd7guj | the Guangzhou experience Potential benefits of precise corticosteroids therapy for severe 2019-nCoV pneumonia Decoding the enigma of antiviral crisis: does one target molecule regulate all? |
| cord-350836-1enteev7 | -I signaling Reversal of the interferon- sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA Approaching the RNA ligand for RIG- I? |
| cord-350836-1enteev7 | A novel role for viral- defective interfering particles in enhancing dendritic cell maturation Defective interfering influenza virus RNAs: time to reevaluate their clinical potential as broad- spectrum antivirals? |
| cord-350836-1enteev7 | Methanococcus jannaschii Unlocking the DEAD- box: a key to cryptococcal virulence? |
| cord-344829-adlp2rjy | ( COVID-19) affect the eyes? |
| cord-344829-adlp2rjy | : a therapeutic target in severe pulmonary inflammation including COVID-19? |
| cord-344829-adlp2rjy | COVID-19: consider cytokine storm syndromes and immunosuppression Clinical features of patients infected with 2019 novel coronavirus in Wuhan Is a"Cytokine Storm"relevant to COVID-19? |
| cord-344829-adlp2rjy | inflammasome signaling promotes atrial fibrillation Increased serum levels of interleukin-1beta in the systemic circulation of patients with essential hypertension: additional risk factor for atherogenesis in hypertensive patients? |
| cord-344829-adlp2rjy | severe acute respiratory syndrome SARS- CoV-2 infects human neural progenitor cells and brain organoids Extracellular vesicles and viruses: are they close relatives? |
| cord-352230-8mazd3eu | IIB inhibits antibody- dependent enhancement of dengue virus infection Immunomodulation by IVIg and the role of Fc- gamma receptors: classic mechanisms of action after all? |
| cord-352230-8mazd3eu | Is the anti- psychotic, 10-(3-(dimethylamino) propyl) phenothiazine( promazine), a potential drug with which to treat SARS infections? |
| cord-334564-bqh9jkds | Evidence from a population- based eleven- year survey in Japan Is living alone"aging alone"? |
| cord-334564-bqh9jkds | If the increase in cytokine levels and the manifestation of psychiatric symptoms are related to the severity of the symptoms of SARS- CoV infection, the"cytokine storm"might also be related to the"mental health thunderstorms"seen in patients with COVID-19? |
| cord-334564-bqh9jkds | Traumatic memories, post- traumatic stress disorder and serum cortisol levels in long- term survivors of the acute respiratory distress syndrome Disrupted glucocorticoid- Immune interactions during stress response in schizophrenia Life events and high- trait reactivity together predict psychotic symptom increases in schizophrenia Increased serum interleukin-6 levels in early stages of psychosis: associations with at- risk mental states and the severity of psychotic symptoms Autoimmune diseases and severe infections as risk factors for schizophrenia: a 30-year population- based register study The psychological impact of quarantine and how to reduce it: rapid review of the evidence Immediate psychological responses and associated factors during the initial stage of the 2019 coronavirus disease( COVID-19) epidemic among the general population in china Living alone and depressive symptoms: the influence of gender, physical disability, and social support among Hispanic and non- Hispanic older adults Living alone and depression: the modifying role of the perceived neighborhood environment Living alone or with others and depressive symptoms, and effect modification by residential social cohesion among older adults in Japan: the JAGES longitudinal study Living arrangements and risk for late life depression: a meta- analysis of published literature Which is riskier for mental health, living alone or not participating in any social activity? |
| cord-334564-bqh9jkds | the epidemic and the challenges Anosmia and ageusia: common findings in COVID-19 patients Posttraumatic stress symptoms and attitude toward crisis mental health services among clinically stable patients with COVID-19 in China Prevalence and factors associated with depression and anxiety of hospitalized patients with COVID-19 A first case of meningitis/ encephalitis associated with SARS- Coronavirus-2 Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system? |
| cord-263141-n200x6z1 | Are similar immune mechanisms activated by the microbiota in high- risk populations( infants, elderly, immunocompromised hosts) in which respiratory viral infections are more frequent and severe? |
| cord-263141-n200x6z1 | Has the microbiota the ability to influence immune responses to other respiratory viruses? |
| cord-263141-n200x6z1 | How the different microbial species from the gut microbiota influence the common mucosal immune system? |
| cord-263141-n200x6z1 | Is it possible to beneficially modulate antiviral respiratory defenses by orally administering selected microorganisms with immunomodulatory capacities? |
| cord-263141-n200x6z1 | Which PRRs are activated by the gut microbiota to functionally modulate antiviral immunity locally and in distal mucosal sites? |
| cord-263141-n200x6z1 | Which cellular functions are modulated by the microbiota after PRR activation? |
| cord-317797-h229skaq | Do platelets contribute to the immune response against SARS- CoV-2? |
| cord-317797-h229skaq | Do platelets release/ synthesize their cytokines and contribute to the cytokine storm in COVID-19 patients? |
| cord-317797-h229skaq | Do the hypercoagulable states synergize with platelet activation, which provide phosphatidylserine, propel the cellbased thrombin generation( 44), and lead to thrombosis? |
| cord-317797-h229skaq | Finally, are platelets friends or foes or able to switch their roles during SARS- CoV-2 infection? |
| cord-317797-h229skaq | Is platelet desialylation a novel biomarker and therapeutic target in immune thrombocytopenia? |
| cord-317797-h229skaq | Is the thrombocytopenia in severe COVID-19 cases caused by the platelet hyperactivities and consumption during micro- thrombi formation? |
| cord-344093-3bniy5b5 | Viral infection and pulmonary hypertension: is there an association? |
| cord-344093-3bniy5b5 | a mechanism for the unusual severity of human disease? |
| cord-344093-3bniy5b5 | inhibits lung edema clearance during influenza infection Approaching the asymptote? |
| cord-344093-3bniy5b5 | interferon: friend or foe? |
| cord-265005-e6rpryrh | How type I interferons work in multiple sclerosis and other diseases: some unexpected mechanisms Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection Does Type I interferon limit protective neutrophil responses during pulmonary Francisella Tularensis infection? |
| cord-265005-e6rpryrh | I IFN receptor- triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara- induced T- cell expansion Antiviral immune responses: triggers of or triggered by autoimmunity? |
| cord-265005-e6rpryrh | Is chronic plaque psoriasis triggered by microbiota in the skin? |
| cord-265005-e6rpryrh | Plasmacytoid dendritic cells suppress HIV-1 replication but contribute to HIV-1 induced immunopathogenesis in humanized mice Chronic hepatitis C: future treatment Host- targeting agents in the treatment of hepatitis C: a beginning and an end? |
| cord-265005-e6rpryrh | Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness Pathology of human influenza revisited Immune dysfunction and bacterial coinfections following influenza Type I interferon: friend or foe? |
| cord-265005-e6rpryrh | The pathology of influenza virus infections How do viral infections predispose patients to bacterial infections? |
| cord-354353-hyz0gmpz | COVID-19 outbreaks? |
| cord-354353-hyz0gmpz | Can PM- virus composites induce infection? |
| cord-354353-hyz0gmpz | Can infectious viruses survive on PM? |
| cord-336924-7xcbtn3q | Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19 Frequent False- positive results of lupus anticoagulant tests in plasmas of patients receiving the new oral anticoagulants and enoxaparin Lupus Anticoagulant( LAC) testing in patients with inflammatory status: Does C- reactive protein interfere with LAC test results? |
| cord-336924-7xcbtn3q | Still Useful? |
| cord-336924-7xcbtn3q | This article has been released as a pre- print at[ medRxiv Pulmonary post- mortem findings in a series of COVID-19 cases from northern Italy: a two- centre descriptive study Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Diagnosis and Management of the Antiphospholipid Syndrome Lupus anticoagulant is frequent in patients with Covid-19 Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19 High Frequency of Antiphospholipid Antibodies in Critically- ill COVID-19 Patients: a Link with Hypercoagulability? |
| cord-336924-7xcbtn3q | When to screen for lupus anticoagulant? |
| cord-325129-faptufak | Could the same considerations apply to COVID-19? |
| cord-325129-faptufak | angiotensin type II receptor SARS- CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? |
| cord-325129-faptufak | authors: Meini, Simone; Zanichelli, Andrea; Sbrojavacca, Rodolfo; Iuri, Federico; Roberts, Anna Teresa; Suffritti, Chiara; Tascini, Carlo title: Understanding the Pathophysiology of COVID-19: Could the Contact System Be the Key? date: 2020- 08- 11 journal: |
| cord-325129-faptufak | towards new molecular targets? |
| cord-313431-swkcdvx8 | Androgen- replacement therapy depresses the ex vivo production of inflammatory cytokines by circulating antigen- presenting cells in aging type-2 diabetic men with partial androgen deficiency Testosterone replacement therapy in hypogonadal men is associated with increased expression of LAMP-2( CD107b) by circulating monocytes and dendritic cells Klinefelter syndrome: integrating genetics, neuropsychology, and endocrinology Morbidity in Klinefelter syndrome: a Danish register study based on hospital discharge diagnoses Klinefelter syndrome and bronchial asthma: Is there any relationship between the low testosterone levels and asthma exacerbations? |
| cord-313431-swkcdvx8 | Gender differences in COPD: are women more susceptible to smoking effects than men? |
| cord-313431-swkcdvx8 | H1N1 influenza A virus infections High mortality from respiratory failure secondary to swineorigin influenza A( H1N1) in South Africa Is there a difference in the immune response, efficacy, effectiveness and safety of seasonal influenza vaccine in males and females? |
| cord-313431-swkcdvx8 | an updated review Asthma in reproductive- aged women with polycystic ovary syndrome and association with obesity Emerging role of HMGB1 in lung diseases: friend or foe Increased levels of serum advanced glycation end- products in women with polycystic ovary syndrome S100A8/ A9: a mediator of severe asthma pathogenesis and morbidity? |
| cord-338498-3238fz73 | Can an effective SARS- CoV-2 vaccine be developed for the older population? |
| cord-338498-3238fz73 | Canadian Immunization Guide Mucosal- local, USP Drug Information for the Healthcare Professional Oncolology Drug Information BCG- different strains, different vaccines? |
| cord-338498-3238fz73 | Is COVID-19 receiving ADE from other coronaviruses? |
| cord-338498-3238fz73 | The efficacy of bacillus calmette- guerin vaccinations for the prevention of acute upper respiratory tract infection in the elderly BCG vaccination protects against experimental viral infection in humans through the induction of cytokines associated with trained immunity BCG- induced trained immunity: can it offer protection against COVID-19? |
| cord-338498-3238fz73 | The non- specific effects of vaccines Randomized trial of BCG vaccination at birth to low- birth- weight children: beneficial nonspecific effects in the neonatal period? |
| cord-338498-3238fz73 | how we age: insights into inflammaging Patients with cancer appear more vulnerable to SARS- CoV-2: a multicenter study during the COVID-19 outbreak Global, regional, and national estimates of the population at increased risk of severe COVID-19 due to underlying health conditions in 2020: a modelling study Relative and absolute effectiveness of high- dose and standard- dose influenza vaccine against influenza- related hospitalization among older adults- United States Is innate immunity our best weapon for flattening the curve? |
| cord-278839-uu2wlpmp | Respiratory viruses and sudden infant death Evaluation of maternal mortality under- reporting in the heights of Chiapas using the RAMOS and modified RAMOS strategies Maternal immunisation: what have been the gains? |
| cord-278839-uu2wlpmp | The expression and localization of the human placental prorenin/ renin- angiotensin system throughout pregnancy: roles in trophoblast invasion and angiogenesis? |
| cord-278839-uu2wlpmp | Viral infections and the neonatal brain Age- specific incidence of influenza A responds to change in virus subtype dominance Pulmonary susceptibility of neonates to respiratory syncytial virus infection: a problem of innate immunity? |
| cord-278839-uu2wlpmp | What does the future hold? |
| cord-278839-uu2wlpmp | Where are the gaps? |
| cord-278839-uu2wlpmp | role of glucocorticoids Hertz- Picciotto I. Is maternal influenza or fever during pregnancy associated with autism or developmental delays? |
| cord-339152-wfakzb6w | : where are we? |
| cord-339152-wfakzb6w | COVID-19 Trained innate immunity not always amicable Scores of coronavirus vaccines are in competition-how will scientists choose the best? |
| cord-339152-wfakzb6w | Covid-19: what do we know so far about a vaccine? |
| cord-339152-wfakzb6w | How severe and prevalent are Ebola and Marburg viruses? |
| cord-321401-w4ne60fn | 25-dihydroxyvitamin D production and receptor binding in human keratinocytes varies with differentiation Where is the vitamin D receptor? |
| cord-321401-w4ne60fn | ECM remodelling in IBD: innocent bystander or partner in crime? |
| cord-321401-w4ne60fn | The association between vitamin D and COPD risk, severity, and exacerbation: an updated systematic review and meta- analysis Vitamin D and asthma- life after VIDA? |
| cord-321401-w4ne60fn | Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D- binding gene Chronic obstructive pulmonary disease is associated with low levels of vitamin D Associations between 25-hydroxy- vitamin D levels, lung function, and exacerbation outcomes in COPD: an analysis of the SPIROMICS cohort Vitamin D deficiency: what does it mean for chronic obstructive pulmonary disease( COPD)? |
| cord-321401-w4ne60fn | an in vitro model PPARγ mediates innate immunity by regulating the 1α,25-dihydroxyvitamin D3 induced hBD-3 and cathelicidin in human keratinocytes Cigarette smoke induced lung barrier dysfunction, EMT, and tissue remodeling: a possible link between COPD and lung cancer Extracellular matrix component remodeling in respiratory diseases: what has been found in clinical and experimental studies? |
| cord-297790-tpjxt0w5 | A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special? |
| cord-297790-tpjxt0w5 | A molecular phylogeny for bats illuminates biogeography and the fossil record Host and viral traits predict zoonotic spillover from mammals Are disease reservoirs special? |
| cord-297790-tpjxt0w5 | Are bats exceptional viral reservoirs? |
| cord-297790-tpjxt0w5 | Do our life history traits make us susceptible to generating damaging immune responses to RNA viruses or does the physiology of bats make them particularly tolerant or resistant? |
| cord-297790-tpjxt0w5 | Mass extinctions, biodiversity and mitochondrial function: are bats'special'as reservoirs for emerging viruses? |
| cord-297790-tpjxt0w5 | What links bats to emerging infectious diseases? |
| cord-354030-8tfg881h | ( http://unafold.rna.albany.edu/? |
| cord-354030-8tfg881h | Immunoinformatics approach The use of databases, data mining, and immunoinformatics in vaccinology: where are we? |
| cord-354030-8tfg881h | The restriction enzyme cutting sites of Xho? |
| cord-354030-8tfg881h | and BamH? were then appended to the N and C terminals, respectively. |
| cord-003828-bhfghcby | A streptococcus and mammalian muscle Spreading of T- cell autoimmunity to cryptic determinants of an autoantigen Antiviral immune responses: triggers of or triggered by autoimmunity? |
| cord-003828-bhfghcby | Can vaccines cause MS and( ii) can vaccines provoke or trigger relapses in patients with MS? |
| cord-003828-bhfghcby | Targeting prohibitins at the cell surface prevents Th17-mediated autoimmunity Immunization in patients with multiple sclerosis Chlamydia pneumoniae infection of the central nervous system in multiple sclerosis Epstein- Barr virus and multiple sclerosis Coronaviruses in brain tissue from patients with multiple sclerosis Active human herpesvirus 6 infection in patients with multiple sclerosis Cerebrospinal fluid molecular demonstration of Chlamydia pneumoniae DNA is associated to clinical and brain magnetic resonance imaging activity in a subset of patients with relapsing- remitting multiple sclerosis Multiple sclerosis, sporadic creutzfeldt- jakob disease and bovine spongiform encephalopathy: are they autoimmune diseases evoked by acinetobacter microbes showing molecular mimicry to brain antigens? |
| cord-003828-bhfghcby | The neuro- paralytic accidents of antirabies treatment Autoimmune encephalitis in humans: how closely does it reflect multiple sclerosis? |
| cord-003828-bhfghcby | The risk of relapses in multiple sclerosis during systemic infections Relapsing encephalomyelitis following the use of influenza vaccine Ocular abnormalities after influenza immunization Acute transverse myelitis after influenza vaccination: magnetic resonance imaging findings Optic neuritis after influenza vaccination Diffuse myelitis associated with rubella vaccination Diffuse myelitis associated with rubella vaccination Transverse myelitis after measles, mumps, and rubella vaccine Optic neuritis complicating measles, mumps, and rubella vaccination Optic neuritis following measles/ rubella vaccination in two 13-year- old children Relapsing acute encephalopathy: a complication of diphtheria- tetanus- poliomyelitis immunization in a young boy Multiple sclerosis and vaccination Central- nervous- system demyelination after immunisation with recombinant hepatitis B vaccine Encephalitis after hepatitis B vaccination: recurrent disseminated encephalitis or MS? |
| cord-003828-bhfghcby | authors: Zrzavy, Tobias; Kollaritsch, Herwig; Rommer, Paulus S.; Boxberger, Nina; Loebermann, Micha; Wimmer, Isabella; Winkelmann, Alexander; Zettl, Uwe K. title: Vaccination in Multiple Sclerosis: Friend or Foe? |
| cord-302295-nblmshni | Approaching the asymptote? |
| cord-302295-nblmshni | How important are Toll- like receptors for antimicrobial responses? |
| cord-302295-nblmshni | Sepsis studies need new direction Recombinant human activated protein C as a therapy for severe sepsis: lessons learned? |
| cord-302295-nblmshni | So, how to explore more efficiently new treatment strategies? |
| cord-302295-nblmshni | Targeting Toll- like receptors: emerging therapeutics? |
| cord-302295-nblmshni | The search for effective therapy for sepsis: back to the drawing board? |
| cord-262673-j2ot35lt | Do men have a higher case fatality rate of severe acute respiratory syndrome than women do? |
| cord-262673-j2ot35lt | H1N1 influenza in the United States Severe morbidity and mortality associated with respiratory syncytial virus versus influenza infection in hospitalized older adults Respiratory syncytial virus infection in elderly and high- risk adults Clinical characteristics and outcomes of human rhinovirus positivity in hospitalized children Detection of human rhinoviruses in the lower respiratory tract of lung transplant recipients Upper and lower respiratory tract infections by human enterovirus and rhinovirus in adult patients with hematological malignancies Middle East respiratory syndrome coronavirus shows poor replication but significant induction of antiviral responses in human monocytederived macrophages and dendritic cells Macrophages: a Trojan horse in COVID-19? |
| cord-262673-j2ot35lt | How the SARS coronavirus causes disease: host or organism? |
| cord-262673-j2ot35lt | Middle East respiratory syndrome coronavirus( MERS- CoV) causes transient lower respiratory tract infection in rhesus macaques Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: a report of nosocomial transmission SARS- CoV2: should inhibitors of the renin- angiotensin system be withdrawn in patients with COVID-19? |
| cord-262673-j2ot35lt | Spatiotemporal interplay of severe acute respiratory syndrome coronavirus and respiratory mucosal cells drives viral dissemination in rhesus macaques Location or origin? |
| cord-262673-j2ot35lt | The involvement of natural killer cells in the pathogenesis of severe acute respiratory syndrome Expression of lymphocytes and lymphocyte subsets in patients with severe acute respiratory syndrome SARS- CoV-2 infection in children: transmission dynamics and clinical characteristics Will children reveal their secret? |
| cord-262673-j2ot35lt | The role of neutrophil extracellular traps in Covid-19: only an hypothesis or a potential new field of research? |
| cord-262673-j2ot35lt | What is critical for macrophage propagation of lung fibrosis? |
| cord-333670-qv1orlv5 | : What Are We Learning in a Country With High Mortality Rate? |
| cord-333670-qv1orlv5 | COVID-19 Pulmonary Involvement: is really an interstitial pneumonia? |
| cord-333670-qv1orlv5 | Could PD-1/ PDL1 immune checkpoints be linked to HLA signature? |
| cord-333670-qv1orlv5 | Is the recommendation to use high- dose heparin for thromboprophylaxis justified? |
| cord-333670-qv1orlv5 | Pulmonary embolism or pulmonary thrombosis in COVID-19? |
| cord-333670-qv1orlv5 | The autopsy debate during the COVID-19 emergency: the Italian experience COVID-19 deaths: are we sure it is pneumonia? |
| cord-333670-qv1orlv5 | The use of antiinflammatory drugs in the treatment of people with severe coronavirus disease 2019( COVID-19): the experience of clinical immunologists from China Is COVID evolution due to occurrence of pulmonary vascular thrombosis? |
| cord-336201-fl606l3b | Increased circulating resistin is associated with insulin resistance, oxidative stress and platelet activation in type 2 diabetes mellitus Increased levels of soluble adhesion molecules in type 2( non- insulin dependent) diabetes mellitus are independent of glycaemic control Molecular mechanisms underpinning microparticle- mediated cellular injury in cardiovascular complications associated with diabetes Association between mean platelet volume in the pathogenesis of type 2 diabetes mellitus and diabetic macrovascular complications in Japanese patients Increased erythrocyte- and platelet- derived microvesicles in newly diagnosed type 2 diabetes mellitus Type 2 diabetes and cardiovascular disease: have all risk factors the same strength? |
| cord-336201-fl606l3b | Low levels of hydrogen sulfide in the blood of diabetes patients and streptozotocintreated rats causes vascular inflammation? |
| cord-336201-fl606l3b | One Health Influenza virus and glycemic variability in diabetes: a killer combination? |
| cord-336201-fl606l3b | The role of methylglyoxal and the glyoxalase system in diabetes and other age- related diseases Role of advanced glycation end products in cardiovascular disease Advanced glycation end products, inflammation, and chronic metabolic diseases: links in a chain? |
| cord-336201-fl606l3b | phosphorylation Functional convergence of Akt protein with VEGFR-1 in human endothelial progenitor cells exposed to sera from patient with type 2 diabetes mellitus Humanin: a harbinger of mitochondrialderived peptides? |
| cord-336201-fl606l3b | seroprevalence, risk factors, and case- control studies Association between helminth infections and diabetes mellitus in adults from the Lao People's Democratic Republic: a cross- sectional study Is there an association between positive Strongyloides stercoralis serology and diabetes mellitus? |
| cord-352737-3ttrx3lf | A review of potential options for therapeutic intervention Ageing of lymphocytes and lymphocytes in the aged Immunosenescence: impact in the young as well as the old? |
| cord-352737-3ttrx3lf | From cell senescence to age- related diseases: differential mechanisms of action of senescenceassociated secretory phenotypes Aging of the human metaorganism: the microbial counterpart The role of oxidative and inflammatory stress and persistent viral infections in immunosenescence Inflammaging and'Garb- aging Telomere dynamics in immune senescence and exhaustion triggered by chronic viral infection Effect of ageing on CMV- specific CD8 T cells from CMV seropositive healthy donors T- cell dysregulation caused by chronic antigenic stress: the role of CMV in immunosenescence? |
| cord-352737-3ttrx3lf | Immunosenescence and inflamm- aging as two sides of the same coin: friends or foes? |
| cord-352737-3ttrx3lf | Immunosenescence and its hallmarks: how to oppose aging strategically? |
| cord-352737-3ttrx3lf | National Institutes of Health( 2020) Estimates of the severity of coronavirus disease 2019: a model- based analysis Aging of the immune system: how much can the adaptive immune system adapt? |
| cord-352737-3ttrx3lf | Physical activity and diet shape the immune system during aging Can physical activity ameliorate immunosenescence and thereby reduce age- related multi- morbidity? |
| cord-352737-3ttrx3lf | The role of immunosenescence in the development of age- related diseases Immune- endocrine biomarkers as predictors of frailty and mortality: a 10-year longitudinal study in community- dwelling older people Predicting death from tumour necrosis factor- alpha and interleukin-6 in 80-year- old people Associations of elevated interleukin-6 and C- reactive protein levels with mortality in the elderly Hallmarks of human"immunosenescence": adaptation or dysregulation? |
| cord-346389-gbmnoo84 | COVID-19 and diabetes: can DPP4 inhibition play a role? |
| cord-346389-gbmnoo84 | COVID-19) The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS- CoV-2 Pulmonary embolism or pulmonary thrombosis in COVID-19? |
| cord-346389-gbmnoo84 | Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS- CoV Remdesivir in adults with severe COVID-19: a randomised, double- blind, placebo- controlled, multicentre trial Gilead Announces Results From Phase 3 Trial of Remdesivir in Patients With Moderate COVID-19 Available online at Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus Survival after mesenchymal stromal cell therapy in steroidrefractory acute graft- versus- host disease: systematic review and metaanalysis Transplantation of ACE2-mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia Extraordinary GUrich single- strand RNA identified from SARS coronavirus contributes an excessive innate immune response Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment Effective treatment of severe COVID-19 patients with tocilizumab Favorable changes of CT findings in a patient with COVID-19 pneumonia after treatment with tocilizumab Tocilizumab, an anti- IL6 receptor antibody, to treat Covid-19-related respiratory failure: a case report Rapid and severe Covid-19 pneumonia with severe acute chest syndrome in a sickle cell patient successfully treated with tocilizumab Dissection of the effects of jak and btk inhibitors on the functionality of healthy and malignant lymphocytes COVID-19: combining antiviral and anti- inflammatory treatments Baricitinib for COVID-19: a suitable treatment? |
| cord-346389-gbmnoo84 | Do men have a higher case fatality rate of severe acute respiratory syndrome than women do? |
| cord-346389-gbmnoo84 | Is the recommendation to use high- dose heparin for thromboprophylaxis justified? |
| cord-346389-gbmnoo84 | Where are we? |
| cord-346389-gbmnoo84 | the battle continues Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-325353-tx6s4ggu | -the first sign of childhood asthma? |
| cord-325353-tx6s4ggu | 3: pathogenesis Exposure to environmental microorganisms and childhood asthma Microbial exposure during early life has persistent effects on natural killer T cell function Vaccination against RSV: is maternal vaccination a good alternative to other approaches? |
| cord-325353-tx6s4ggu | Alveolar macrophages contribute to the pathogenesis of human metapneumovirus infection while protecting against respiratory syncytial virus infection Alveolar macrophage- derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes Influenza virus reservoirs and intermediate hosts: dogs, horses, and new possibilities for influenza virus exposure of humans Epidemiology and etiology of childhood pneumonia in 2010: estimates of incidence, severe morbidity, mortality, underlying risk factors and causative pathogens for 192 countries Vaccines for preventing influenza in healthy children Every year is an influenza pandemic for children: can we stop them? |
| cord-325353-tx6s4ggu | CD4+ T and ICOS+ ST2+ non- T( ILC2?) |
| cord-325353-tx6s4ggu | Do early- life viral infections cause asthma? |
| cord-325353-tx6s4ggu | In the case of human clinical data, it is difficult to resolve the"chicken- and- egg"problem: do children with a genetic propensity to mount Th2 responses and develop asthma suffer more severe early- life RSV or does early and severe RSV infection cause the subsequent development of asthma( 83, 168)? |
| cord-325353-tx6s4ggu | The global burden of asthma Asthma and allergic inflammation Asthma: epidemiology, etiology and risk factors Risk factors for asthma: is prevention possible? |
| cord-325353-tx6s4ggu | Thymic stromal lymphopoietin is induced by respiratory syncytial virus- infected airway epithelial cells and promotes a type 2 response to infection Timing of infection and prior immunization with respiratory syncytial virus( RSV) in RSV- enhanced allergic inflammation A role for airway remodeling during respiratory syncytial virus infection Enhanced allergic responsiveness after early childhood infection with respiratory viruses: are long- lived alternatively activated macrophages the missing link? |
| cord-325353-tx6s4ggu | origin, effect, and prevention Response to infections in patients with asthma and atopic disease: an epiphenomenon or reflection of host susceptibility? |
| cord-264814-v4wnmg03 | Antigenspecific human T- cell responses and T cell- dependent production of human antibodies in a humanized mouse model A mouse model of SARS- CoV-2 infection and pathogenesis Adaptation of SARS- CoV-2 in BALB/ c mice for testing vaccine efficacy Vaccine adjuvants: smart components to boost the immune system Correlates of adjuvanticity: a review on adjuvants in licensed vaccines Potential adjuvants for the development of a SARS- CoV-2 vaccine based on experimental results from similar coronaviruses Development of SARS- CoV-2 vaccines: should we focus on mucosal immunity? |
| cord-264814-v4wnmg03 | Available online at A single- dose live- attenuated YF17D- vectored SARS- CoV2 vaccine candidate DNA vaccines- how far from clinical use? |
| cord-264814-v4wnmg03 | COVID-19: are neutralizing antibodies neutralizing enough? |
| cord-264814-v4wnmg03 | Is BCG vaccination causally related to reduced COVID-19 mortality? |
| cord-264814-v4wnmg03 | Protection or Hyper- Activation? |
| cord-264814-v4wnmg03 | T Cell Adaptive Immunity: Protection, Immune Suppression or Disease Enhancement? |
| cord-264814-v4wnmg03 | The Spread of COVID-19 and the BCG Vaccine: a Natural Experiment in Reunified Germany SARS- CoV-2 rates in BCGvaccinated and unvaccinated young adults BCG- induced trained immunity: can it offer protection against COVID-19? |
| cord-264814-v4wnmg03 | With Task Force Vaccine Safety Expert A controlled human infection model of group a streptococcus pharyngitis: which strain and why? |
| cord-264814-v4wnmg03 | a six- year follow- up study Recovery from the middle east respiratory syndrome is associated with antibody and T- cell responses Immune cell profiling of COVID-19 patients in the recovery stage by single- cell sequencing Immunology of COVID-19: current state of the science Molecular basis of coronavirus virulence and vaccine development SARS vaccines: where are we? |
| cord-264814-v4wnmg03 | how first exposure shapes lifelong anti- influenza virus immune responses Original antigenic sin and respiratory syncytial virus vaccines What about the original antigenic sin of the humans versus SARS- CoV-2? |
| cord-264814-v4wnmg03 | mSphere Regulatory T cells in arterivirus and coronavirus infections: do they protect against disease or enhance it? |
| cord-320663-xypg6evo | Activating KIRs and NKG2C in viral infections: toward NK cell memory? |
| cord-320663-xypg6evo | Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-320663-xypg6evo | COVID-19 and treatment with NSAIDs and corticosteroids: should we be limiting their use in the clinical setting? |
| cord-320663-xypg6evo | Does COVID-19 spread through droplets alone? |
| cord-320663-xypg6evo | Have I found the missing ingredient in a coronavirus vaccine? |
| cord-320663-xypg6evo | How is immunosuppressive status affecting children and adults in SARS- CoV-2 infection? |
| cord-320663-xypg6evo | The SARS, MERS and novel coronavirus( COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? |
| cord-320663-xypg6evo | The innate immune system: fighting on the front lines or fanning the flames of COVID-19? |
| cord-320663-xypg6evo | The role of the interleukin-1 family in trained immunity Training the trainable cells of the immune system and beyond BCG- induced trained immunity: can it offer protection against COVID-19? |
| cord-320663-xypg6evo | The trafficking of natural killer cells Keeping NK cells in highly regulated antiviral warfare Human NK cell lytic granules and regulation of their exocytosis Natural killer cells: development, maturation, and clinical utilization Natural killer cell memory in infection, inflammation and cancer About training and memory: NK- cell adaptation to viral infections Is there natural killer cell memory and can it be harnessed by vaccination? |
| cord-320663-xypg6evo | The use of antiinflammatory drugs in the treatment of people with severe coronavirus disease 2019( COVID-19): the perspectives of clinical immunologists from China Adjunct immunotherapies for the management of severely Ill COVID-19 patients HiJAKing SARS- CoV-2? |
| cord-320663-xypg6evo | interferon responses: from friend to foe in the battle against chronic viral infection NK cells and interferons Innate or adaptive immunity? |
| cord-285760-y37ji92k | 9 strain of live attenuated mumps vaccine in comparison with the Jeryl Lynn strain Safety and characterization of the immune response engendered by two combined measles, mumps and rubella vaccines Horizontal transmission of the Leningrad-3 live attenuated mumps vaccine virus Mumps antibody levels among students before a mumps outbreak: in search of a correlate of immunity Primary vaccine failure after 1 dose of varicella vaccine in healthy children Outbreak of mumps in a vaccinated child population: a question of vaccine failure? |
| cord-285760-y37ji92k | : a ten year longitudinal cohort study of American children born in the 1990s Duration of humoral immunity to common viral and vaccine antigens Mumps outbreaks in vaccinated populations: are available mumps vaccines effective enough to prevent outbreaks? |
| cord-285760-y37ji92k | Available online at: https://vaccineschedule.ecdc.europa.eu/Scheduler/ByDisease? |
| cord-285760-y37ji92k | Correlates of lymphoproliferative responses to measles, mumps, and rubella( MMR) virus vaccines following MMR- II vaccination in healthy children Detection of mumps virus- specific memory B cells by transfer of peripheral blood mononuclear cells into immune- deficient mice Are cases of mumps in vaccinated patients attributable to mismatches in both vaccine T- cell and B- cell epitopes? |
| cord-285760-y37ji92k | Does the medical profession and the"pro- vaccine"message contribute to the public skepticism regarding immunization? |
| cord-285760-y37ji92k | How is a response to a vaccine determined? |
| cord-285760-y37ji92k | Is it time to shift the medical and public perception paradigm from"protection of infection following vaccination"to"protection from serious clinical mumps manifestation"? |
| cord-285760-y37ji92k | Molecular signatures of antibody responses derived from a systems biology study of five human vaccines Influenza immunization elicits antibodies specific for an egg- adapted vaccine strain Influenza vaccine failure: failure to protect or failure to understand? |
| cord-285760-y37ji92k | RT%2DPCR%20and% 20viral%20culture, aid%20in%20diagnosing%20mumps%20infection Diagnosis of acute mumps infection during an outbreak in a highly vaccinated population: mumps RNA or mumps IgM detection? |
| cord-285760-y37ji92k | The case numbers of more recent mumps outbreaks should always be assessed with this question in mind; are the number of mumps cases increasing, or/ and are we better at diagnosing an acute infection? |
| cord-285760-y37ji92k | The establishment of surrogates and correlates of protection: useful tools for the licensure of effective influenza vaccines? |
| cord-285760-y37ji92k | The role of systems biology approaches in determining molecular signatures for the development of more effective vaccines Adjuvants and alternative routes of administration towards the development of the ideal influenza vaccine Trained immunity- based vaccines: a new paradigm for the development of broad- spectrum anti- infectious formulations Could an unrelated live attenuated vaccine serve as a preventive measure to dampen septic inflammation associated with COVID-19 infection? |
| cord-285760-y37ji92k | Therefore, does"immunity"refer to sterile immunity or solely to protection from symptomatic infection? |
| cord-285760-y37ji92k | Therefore, if a correlate or surrogate correlate is unobtainable to define an individual's protection to mumps, should we re- consider and re- focus efforts on optimizing the vaccine using available historical clinical and trial data? |
| cord-285760-y37ji92k | What defines an effective vaccine, or what constitutes vaccine failure? |
| cord-285760-y37ji92k | Why Do We Consider Antibodies to Be the Best Measurement of Vaccine Efficacy? |
| cord-285760-y37ji92k | key: cord-285760-y37ji92k authors: Connell, Anna R.; Connell, Jeff; Leahy, T. Ronan; Hassan, Jaythoon title: Mumps Outbreaks in Vaccinated Populations — Is It Time to Re- assess the Clinical Efficacy of Vaccines? |
| cord-285760-y37ji92k | the nova scotia experience Mumps outbreak and laboratory diagnosis Antibody Fab- Fc properties outperform titer in predictive models of SIV vaccine- induced protection Increase in mumps in Ireland in late Assessment of mumps virus- specific antibodies by different serological assays: which test correlates best with mumps immunity? |
| cord-285760-y37ji92k | why and what to do? |